Search of human proteins with 4557369

Search of human proteins with 4557369

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4557369 bone morphogenetic protein 2 preproprotein [Homo
sapiens]
         (396 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4557369 bone morphogenetic protein 2 preproprotein [Homo sapi...   812   0.0  
gi|157276597 bone morphogenetic protein 4 preproprotein [Homo sa...   484   e-137
gi|157276595 bone morphogenetic protein 4 preproprotein [Homo sa...   484   e-137
gi|157276593 bone morphogenetic protein 4 preproprotein [Homo sa...   484   e-137
gi|4502427 bone morphogenetic protein 7 precursor [Homo sapiens]      191   8e-49
gi|4502425 bone morphogenetic protein 6 preproprotein [Homo sapi...   186   3e-47
gi|7656928 bone morphogenetic protein 10 preproprotein [Homo sap...   177   1e-44
gi|10835091 bone morphogenetic protein 5 preproprotein [Homo sap...   176   3e-44
gi|29571106 bone morphogenetic protein 8B preproprotein [Homo sa...   171   1e-42
gi|145611428 bone morphogenetic protein 8A [Homo sapiens]             170   2e-42
gi|10190670 growth differentiation factor 3 precursor [Homo sapi...   155   6e-38
gi|4503969 growth differentiation factor 5 preproprotein [Homo s...   154   1e-37
gi|61835232 growth differentiation factor 7 preproprotein [Homo ...   150   2e-36
gi|7705308 growth differentiation factor 2 [Homo sapiens]             144   2e-34
gi|48475062 growth differentiation factor 6 precursor [Homo sapi...   139   6e-33
gi|4504699 inhibin beta A precursor [Homo sapiens]                    122   4e-28
gi|126507087 bone morphogenetic protein 3 preproprotein [Homo sa...   119   6e-27
gi|4826740 growth differentiation factor 10 precursor [Homo sapi...   113   3e-25
gi|154813204 inhibin beta B subunit preproprotein [Homo sapiens]      105   9e-23
gi|222352098 nodal precursor [Homo sapiens]                           103   2e-22
gi|4885097 bone morphogenetic protein 15 precursor [Homo sapiens]     102   8e-22
gi|110349792 growth differentiation factor 1 [Homo sapiens]           101   1e-21
gi|13899338 activin beta E [Homo sapiens]                             100   4e-21
gi|4885259 myostatin [Homo sapiens]                                    99   9e-21
gi|5031795 inhibin beta C chain preproprotein [Homo sapiens]           97   2e-20
gi|4507465 transforming growth factor, beta 3 [Homo sapiens]           94   3e-19
gi|208022653 transforming growth factor, beta 2 isoform 1 [Homo ...    89   7e-18
gi|4507463 transforming growth factor, beta 2 isoform 2 [Homo sa...    89   7e-18
gi|4885261 growth differentiation factor 9 precursor [Homo sapiens]    86   6e-17
gi|5031613 growth differentiation factor 11 precursor [Homo sapi...    84   2e-16

>gi|4557369 bone morphogenetic protein 2 preproprotein [Homo
           sapiens]
          Length = 396

 Score =  812 bits (2098), Expect = 0.0
 Identities = 396/396 (100%), Positives = 396/396 (100%)

Query: 1   MVAGTRCLLALLLPQVLLGGAAGLVPELGRRKFAAASSGRPSSQPSDEVLSEFELRLLSM 60
           MVAGTRCLLALLLPQVLLGGAAGLVPELGRRKFAAASSGRPSSQPSDEVLSEFELRLLSM
Sbjct: 1   MVAGTRCLLALLLPQVLLGGAAGLVPELGRRKFAAASSGRPSSQPSDEVLSEFELRLLSM 60

Query: 61  FGLKQRPTPSRDAVVPPYMLDLYRRHSGQPGSPAPDHRLERAASRANTVRSFHHEESLEE 120
           FGLKQRPTPSRDAVVPPYMLDLYRRHSGQPGSPAPDHRLERAASRANTVRSFHHEESLEE
Sbjct: 61  FGLKQRPTPSRDAVVPPYMLDLYRRHSGQPGSPAPDHRLERAASRANTVRSFHHEESLEE 120

Query: 121 LPETSGKTTRRFFFNLSSIPTEEFITSAELQVFREQMQDALGNNSSFHHRINIYEIIKPA 180
           LPETSGKTTRRFFFNLSSIPTEEFITSAELQVFREQMQDALGNNSSFHHRINIYEIIKPA
Sbjct: 121 LPETSGKTTRRFFFNLSSIPTEEFITSAELQVFREQMQDALGNNSSFHHRINIYEIIKPA 180

Query: 181 TANSKFPVTRLLDTRLVNQNASRWESFDVTPAVMRWTAQGHANHGFVVEVAHLEEKQGVS 240
           TANSKFPVTRLLDTRLVNQNASRWESFDVTPAVMRWTAQGHANHGFVVEVAHLEEKQGVS
Sbjct: 181 TANSKFPVTRLLDTRLVNQNASRWESFDVTPAVMRWTAQGHANHGFVVEVAHLEEKQGVS 240

Query: 241 KRHVRISRSLHQDEHSWSQIRPLLVTFGHDGKGHPLHKREKRQAKHKQRKRLKSSCKRHP 300
           KRHVRISRSLHQDEHSWSQIRPLLVTFGHDGKGHPLHKREKRQAKHKQRKRLKSSCKRHP
Sbjct: 241 KRHVRISRSLHQDEHSWSQIRPLLVTFGHDGKGHPLHKREKRQAKHKQRKRLKSSCKRHP 300

Query: 301 LYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNSKIPKAC 360
           LYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNSKIPKAC
Sbjct: 301 LYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNSKIPKAC 360

Query: 361 CVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR 396
           CVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR
Sbjct: 361 CVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR 396


>gi|157276597 bone morphogenetic protein 4 preproprotein [Homo
           sapiens]
          Length = 408

 Score =  484 bits (1247), Expect = e-137
 Identities = 258/414 (62%), Positives = 303/414 (73%), Gaps = 24/414 (5%)

Query: 1   MVAGTRCLLALLLPQVLLGGA--AGLVPELGRRKFAAA---SSGRPSSQPSDEVLSEFEL 55
           M+ G R L+ +LL QVLLGGA  A L+PE G++K A     + GR S Q S E+L +FE 
Sbjct: 1   MIPGNRMLMVVLLCQVLLGGASHASLIPETGKKKVAEIQGHAGGRRSGQ-SHELLRDFEA 59

Query: 56  RLLSMFGLKQRPTPSRDAVVPPYMLDLYRRHSGQP--------GSPAPDHRLERAASRAN 107
            LL MFGL++RP PS+ AV+P YM DLYR  SG+         G   P    ER ASRAN
Sbjct: 60  TLLQMFGLRRRPQPSKSAVIPDYMRDLYRLQSGEEEEEQIHSTGLEYP----ERPASRAN 115

Query: 108 TVRSFHHEESLEELPETSGKTTRRFFFNLSSIPTEEFITSAELQVFREQMQDALGNNSSF 167
           TVRSFHHEE LE +P TS  +  RF FNLSSIP  E I+SAEL++FREQ+         F
Sbjct: 116 TVRSFHHEEHLENIPGTSENSAFRFLFNLSSIPENEVISSAELRLFREQVDQGPDWERGF 175

Query: 168 HHRINIYEIIKP-ATANSKFPVTRLLDTRLVNQNASRWESFDVTPAVMRWTAQGHANHGF 226
           H RINIYE++KP A       +TRLLDTRLV+ N +RWE+FDV+PAV+RWT +   N+G 
Sbjct: 176 H-RINIYEVMKPPAEVVPGHLITRLLDTRLVHHNVTRWETFDVSPAVLRWTREKQPNYGL 234

Query: 227 VVEVAHLEEKQGVSKRHVRISRSLHQDEHSWSQIRPLLVTFGHDGKGHPL--HKREKRQA 284
            +EV HL + +    +HVRISRSL Q   +W+Q+RPLLVTFGHDG+GH L   +R KR  
Sbjct: 235 AIEVTHLHQTRTHQGQHVRISRSLPQGSGNWAQLRPLLVTFGHDGRGHALTRRRRAKRSP 294

Query: 285 KH-KQRKRLKS-SCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNH 342
           KH  QR R K+ +C+RH LYVDFSDVGWNDWIVAPPGY AFYCHG+CPFPLADHLNSTNH
Sbjct: 295 KHHSQRARKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNH 354

Query: 343 AIVQTLVNSVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR 396
           AIVQTLVNSVNS IPKACCVPTELSAISMLYLDE +KVVLKNYQ+MVVEGCGCR
Sbjct: 355 AIVQTLVNSVNSSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR 408


>gi|157276595 bone morphogenetic protein 4 preproprotein [Homo
           sapiens]
          Length = 408

 Score =  484 bits (1247), Expect = e-137
 Identities = 258/414 (62%), Positives = 303/414 (73%), Gaps = 24/414 (5%)

Query: 1   MVAGTRCLLALLLPQVLLGGA--AGLVPELGRRKFAAA---SSGRPSSQPSDEVLSEFEL 55
           M+ G R L+ +LL QVLLGGA  A L+PE G++K A     + GR S Q S E+L +FE 
Sbjct: 1   MIPGNRMLMVVLLCQVLLGGASHASLIPETGKKKVAEIQGHAGGRRSGQ-SHELLRDFEA 59

Query: 56  RLLSMFGLKQRPTPSRDAVVPPYMLDLYRRHSGQP--------GSPAPDHRLERAASRAN 107
            LL MFGL++RP PS+ AV+P YM DLYR  SG+         G   P    ER ASRAN
Sbjct: 60  TLLQMFGLRRRPQPSKSAVIPDYMRDLYRLQSGEEEEEQIHSTGLEYP----ERPASRAN 115

Query: 108 TVRSFHHEESLEELPETSGKTTRRFFFNLSSIPTEEFITSAELQVFREQMQDALGNNSSF 167
           TVRSFHHEE LE +P TS  +  RF FNLSSIP  E I+SAEL++FREQ+         F
Sbjct: 116 TVRSFHHEEHLENIPGTSENSAFRFLFNLSSIPENEVISSAELRLFREQVDQGPDWERGF 175

Query: 168 HHRINIYEIIKP-ATANSKFPVTRLLDTRLVNQNASRWESFDVTPAVMRWTAQGHANHGF 226
           H RINIYE++KP A       +TRLLDTRLV+ N +RWE+FDV+PAV+RWT +   N+G 
Sbjct: 176 H-RINIYEVMKPPAEVVPGHLITRLLDTRLVHHNVTRWETFDVSPAVLRWTREKQPNYGL 234

Query: 227 VVEVAHLEEKQGVSKRHVRISRSLHQDEHSWSQIRPLLVTFGHDGKGHPL--HKREKRQA 284
            +EV HL + +    +HVRISRSL Q   +W+Q+RPLLVTFGHDG+GH L   +R KR  
Sbjct: 235 AIEVTHLHQTRTHQGQHVRISRSLPQGSGNWAQLRPLLVTFGHDGRGHALTRRRRAKRSP 294

Query: 285 KH-KQRKRLKS-SCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNH 342
           KH  QR R K+ +C+RH LYVDFSDVGWNDWIVAPPGY AFYCHG+CPFPLADHLNSTNH
Sbjct: 295 KHHSQRARKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNH 354

Query: 343 AIVQTLVNSVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR 396
           AIVQTLVNSVNS IPKACCVPTELSAISMLYLDE +KVVLKNYQ+MVVEGCGCR
Sbjct: 355 AIVQTLVNSVNSSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR 408


>gi|157276593 bone morphogenetic protein 4 preproprotein [Homo
           sapiens]
          Length = 408

 Score =  484 bits (1247), Expect = e-137
 Identities = 258/414 (62%), Positives = 303/414 (73%), Gaps = 24/414 (5%)

Query: 1   MVAGTRCLLALLLPQVLLGGA--AGLVPELGRRKFAAA---SSGRPSSQPSDEVLSEFEL 55
           M+ G R L+ +LL QVLLGGA  A L+PE G++K A     + GR S Q S E+L +FE 
Sbjct: 1   MIPGNRMLMVVLLCQVLLGGASHASLIPETGKKKVAEIQGHAGGRRSGQ-SHELLRDFEA 59

Query: 56  RLLSMFGLKQRPTPSRDAVVPPYMLDLYRRHSGQP--------GSPAPDHRLERAASRAN 107
            LL MFGL++RP PS+ AV+P YM DLYR  SG+         G   P    ER ASRAN
Sbjct: 60  TLLQMFGLRRRPQPSKSAVIPDYMRDLYRLQSGEEEEEQIHSTGLEYP----ERPASRAN 115

Query: 108 TVRSFHHEESLEELPETSGKTTRRFFFNLSSIPTEEFITSAELQVFREQMQDALGNNSSF 167
           TVRSFHHEE LE +P TS  +  RF FNLSSIP  E I+SAEL++FREQ+         F
Sbjct: 116 TVRSFHHEEHLENIPGTSENSAFRFLFNLSSIPENEVISSAELRLFREQVDQGPDWERGF 175

Query: 168 HHRINIYEIIKP-ATANSKFPVTRLLDTRLVNQNASRWESFDVTPAVMRWTAQGHANHGF 226
           H RINIYE++KP A       +TRLLDTRLV+ N +RWE+FDV+PAV+RWT +   N+G 
Sbjct: 176 H-RINIYEVMKPPAEVVPGHLITRLLDTRLVHHNVTRWETFDVSPAVLRWTREKQPNYGL 234

Query: 227 VVEVAHLEEKQGVSKRHVRISRSLHQDEHSWSQIRPLLVTFGHDGKGHPL--HKREKRQA 284
            +EV HL + +    +HVRISRSL Q   +W+Q+RPLLVTFGHDG+GH L   +R KR  
Sbjct: 235 AIEVTHLHQTRTHQGQHVRISRSLPQGSGNWAQLRPLLVTFGHDGRGHALTRRRRAKRSP 294

Query: 285 KH-KQRKRLKS-SCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNH 342
           KH  QR R K+ +C+RH LYVDFSDVGWNDWIVAPPGY AFYCHG+CPFPLADHLNSTNH
Sbjct: 295 KHHSQRARKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNH 354

Query: 343 AIVQTLVNSVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR 396
           AIVQTLVNSVNS IPKACCVPTELSAISMLYLDE +KVVLKNYQ+MVVEGCGCR
Sbjct: 355 AIVQTLVNSVNSSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR 408


>gi|4502427 bone morphogenetic protein 7 precursor [Homo sapiens]
          Length = 431

 Score =  191 bits (486), Expect = 8e-49
 Identities = 126/392 (32%), Positives = 187/392 (47%), Gaps = 62/392 (15%)

Query: 52  EFELRLLSMFGLKQRPTP---SRDAVVPPYMLDLYR----RHSGQPGSPAPDHRLERAAS 104
           E +  +LS+ GL  RP P    +    P +MLDLY        G PG     +  +   S
Sbjct: 53  EMQREILSILGLPHRPRPHLQGKHNSAPMFMLDLYNAMAVEEGGGPGGQGFSYPYKAVFS 112

Query: 105 R----------------ANTVRSFHHEESLEELPETSGKTTRRFFFNLSSIPTEEFITSA 148
                            A+ V SF +    ++         R F F+LS IP  E +T+A
Sbjct: 113 TQGPPLASLQDSHFLTDADMVMSFVNLVEHDKEFFHPRYHHREFRFDLSKIPEGEAVTAA 172

Query: 149 ELQVFREQMQDALGNNSSFHHRINIYEIIKPATANSKFPVTRLLDTRLVNQNASRWESFD 208
           E +++++ +++   N +    RI++Y++++            LLD+R +  +   W  FD
Sbjct: 173 EFRIYKDYIRERFDNET---FRISVYQVLQEHLGRESDLF--LLDSRTLWASEEGWLVFD 227

Query: 209 VTPAVMRWTAQGHANHGFVVEVAHLEEKQGVSKRHVRISRSLHQDEHSWSQIRPLLVTFG 268
           +T     W      N G  + V  L+ +    K    I R      H     +P +V F 
Sbjct: 228 ITATSNHWVVNPRHNLGLQLSVETLDGQSINPKLAGLIGR------HGPQNKQPFMVAFF 281

Query: 269 HDGKGHPLHKREKRQAKHKQRKRLKS------------------------SCKRHPLYVD 304
              K   +H R  R    KQR + +S                        +CK+H LYV 
Sbjct: 282 ---KATEVHFRSIRSTGSKQRSQNRSKTPKNQEALRMANVAENSSSDQRQACKKHELYVS 338

Query: 305 FSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNSK-IPKACCVP 363
           F D+GW DWI+AP GY A+YC GEC FPL  ++N+TNHAIVQTLV+ +N + +PK CC P
Sbjct: 339 FRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPETVPKPCCAP 398

Query: 364 TELSAISMLYLDENEKVVLKNYQDMVVEGCGC 395
           T+L+AIS+LY D++  V+LK Y++MVV  CGC
Sbjct: 399 TQLNAISVLYFDDSSNVILKKYRNMVVRACGC 430


>gi|4502425 bone morphogenetic protein 6 preproprotein [Homo
           sapiens]
          Length = 513

 Score =  186 bits (472), Expect = 3e-47
 Identities = 123/357 (34%), Positives = 179/357 (50%), Gaps = 40/357 (11%)

Query: 65  QRPTPSRDAVVPPYMLDLYRRHSGQPG-SPAPDHRLERAASRANTVRSFHHEESLEELPE 123
           QR  P   A  P     L    SG  G SP    +     + A+ V SF +    ++   
Sbjct: 170 QRRQPPPGAAHPLNRKSLLAPGSGSGGASPLTSAQDSAFLNDADMVMSFVNLVEYDKEFS 229

Query: 124 TSGKTTRRFFFNLSSIPTEEFITSAELQVFREQMQDALGNNSSFHHRINIYEIIKPATAN 183
              +  + F FNLS IP  E +T+AE +++++ +  +  N +     I+IY++++     
Sbjct: 230 PRQRHHKEFKFNLSQIPEGEVVTAAEFRIYKDCVMGSFKNQTFL---ISIYQVLQEHQHR 286

Query: 184 SKFPVTRLLDTRLVNQNASRWESFDVTPAVMRWTAQGHANHGFVVEVAHLEEKQGVSKRH 243
                  LLDTR+V  +   W  FD+T     W      N G  + V     + GV   H
Sbjct: 287 DSDLF--LLDTRVVWASEEGWLEFDITATSNLWVVTPQHNMGLQLSVV---TRDGVHV-H 340

Query: 244 VRISRSLHQDEHSWSQIRPLLVTFGHDGKGHPLHKREKRQAKHKQRKR------------ 291
            R +  + +D     Q  P +V F    K   +H R  R A  ++R++            
Sbjct: 341 PRAAGLVGRDGPYDKQ--PFMVAFF---KVSEVHVRTTRSASSRRRQQSRNRSTQSQDVA 395

Query: 292 ------------LKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNS 339
                       LK++C++H LYV F D+GW DWI+AP GY A YC GEC FPL  H+N+
Sbjct: 396 RVSSASDYNSSELKTACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNA 455

Query: 340 TNHAIVQTLVNSVNSK-IPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGC 395
           TNHAIVQTLV+ +N + +PK CC PT+L+AIS+LY D+N  V+LK Y++MVV  CGC
Sbjct: 456 TNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYFDDNSNVILKKYRNMVVRACGC 512


>gi|7656928 bone morphogenetic protein 10 preproprotein [Homo
           sapiens]
          Length = 424

 Score =  177 bits (449), Expect = 1e-44
 Identities = 123/389 (31%), Positives = 179/389 (46%), Gaps = 59/389 (15%)

Query: 49  VLSEFELRLLSMFGLKQRPTPSRDAVVPP-YMLDLYRRHSGQPGSPAPDHRLERAASRAN 107
           +L   +   L    L   PT     V PP YML+LY + +    S             AN
Sbjct: 54  LLQSMKDEFLKTLNLSDIPTQDSAKVDPPEYMLELYNKFATDRTS----------MPSAN 103

Query: 108 TVRSFHHEESLEELPETSGKTTRRFFFNLSSIPTEEFITSAELQVFREQMQDALGNNSSF 167
            +RSF +E+   +    +G       FN+S IP  E +  AEL+++    +D +  +   
Sbjct: 104 IIRSFKNEDLFSQPVSFNGLRKYPLLFNVS-IPHHEEVIMAELRLYTLVQRDRMIYDG-V 161

Query: 168 HHRINIYEIIKPATANSKFPVTRLLDTRLVNQNASRWESFDVTPAVMRWTAQGHANHGFV 227
             +I I+E+++    N       +L +  +    S WE+FDVT A+ RW   G + H   
Sbjct: 162 DRKITIFEVLESKGDNEGERNMLVLVSGEIYGTNSEWETFDVTDAIRRWQKSGSSTHQLE 221

Query: 228 VEV-AHLEEKQGVSKRHVRISRSLHQDEHSWSQIRPLLVTFGHDGKGHPLHKREKRQA-K 285
           V + +  +E +  S   + I  S  Q++H+     PLL+ F  D       K E  +   
Sbjct: 222 VHIESKHDEAEDASSGRLEIDTSA-QNKHN-----PLLIVFSDDQSSDKERKEELNEMIS 275

Query: 286 HKQ------------------------------------RKRLKSS-CKRHPLYVDFSDV 308
           H+Q                                    R+  K + CKR PLY+DF ++
Sbjct: 276 HEQLPELDNLGLDSFSSGPGEEALLQMRSNIIYDSTARIRRNAKGNYCKRTPLYIDFKEI 335

Query: 309 GWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNS-KIPKACCVPTELS 367
           GW+ WI+APPGY A+ C G C +PLA+HL  T HAI+Q LV+  NS K  KACCVPT+L 
Sbjct: 336 GWDSWIIAPPGYEAYECRGVCNYPLAEHLTPTKHAIIQALVHLKNSQKASKACCVPTKLE 395

Query: 368 AISMLYLDENEKVVLKNYQDMVVEGCGCR 396
            IS+LYLD+        Y+ M V  CGCR
Sbjct: 396 PISILYLDKGVVTYKFKYEGMAVSECGCR 424


>gi|10835091 bone morphogenetic protein 5 preproprotein [Homo
           sapiens]
          Length = 454

 Score =  176 bits (446), Expect = 3e-44
 Identities = 123/409 (30%), Positives = 180/409 (44%), Gaps = 70/409 (17%)

Query: 52  EFELRLLSMFGLKQRPTP----SRDAVVPPYMLDLYRRHSGQP----------------- 90
           E +  +LS+ GL  RP P     + +  P +MLDLY   + +                  
Sbjct: 50  EIQREILSILGLPHRPRPFSPGKQASSAPLFMLDLYNAMTNEENPEESEYSVRASLAEET 109

Query: 91  -----GSPAPDHRLERAASRANTVRSFHHEESLEELPETS-------------------- 125
                G PA  +   R    + T         L  L +T+                    
Sbjct: 110 RGARKGYPASPNGYPRRIQLSRTTPLTTQSPPLASLHDTNFLNDADMVMSFVNLVERDKD 169

Query: 126 ----GKTTRRFFFNLSSIPTEEFITSAELQVFREQMQDALGNNSSFHHRINIYEIIKPAT 181
                +  + F F+L+ IP  E +T+AE ++++++  +   N +    +I+IY+IIK  T
Sbjct: 170 FSHQRRHYKEFRFDLTQIPHGEAVTAAEFRIYKDRSNNRFENETI---KISIYQIIKEYT 226

Query: 182 ANSKFPVTRLLDTRLVNQNASRWESFDVTPAVMRWTAQGHANHGFV------------VE 229
             ++     LLDTR        W  FD+T     W      N G              V+
Sbjct: 227 --NRDADLFLLDTRKAQALDVGWLVFDITVTSNHWVINPQNNLGLQLCAETGDGRSINVK 284

Query: 230 VAHLEEKQGVSKRHVRISRSLHQDEHSWSQIRPLLVTFGHDGKGHPLHKREKRQAK--HK 287
            A L  +QG   +   +       E     +R        +      H+   R +     
Sbjct: 285 SAGLVGRQGPQSKQPFMVAFFKASEVLLRSVRAANKRKNQNRNKSSSHQDSSRMSSVGDY 344

Query: 288 QRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQT 347
                K +CK+H LYV F D+GW DWI+AP GY AFYC GEC FPL  H+N+TNHAIVQT
Sbjct: 345 NTSEQKQACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQT 404

Query: 348 LVNSV-NSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGC 395
           LV+ +    +PK CC PT+L+AIS+LY D++  V+LK Y++MVV  CGC
Sbjct: 405 LVHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGC 453


>gi|29571106 bone morphogenetic protein 8B preproprotein [Homo
           sapiens]
          Length = 402

 Score =  171 bits (433), Expect = 1e-42
 Identities = 131/424 (30%), Positives = 203/424 (47%), Gaps = 60/424 (14%)

Query: 4   GTRCLLALLLPQVLLGGAAGLVPELGRRKFAAASSGRPSSQPSDEVLSEFELRLLSMFGL 63
           G   LL L L   L GG  GL P            G P  +       + +  +L++ GL
Sbjct: 6   GPLWLLGLALC-ALGGGGPGLRPP----------PGCPQRRLGARERRDVQREILAVLGL 54

Query: 64  KQRPTPSRD-------AVVPPYMLDLYRRHSG---QPGSPAPDHRLERAASRANTVRSFH 113
             RP P          A  P +MLDLY   +G   + G+PA     ER   RA+ V SF 
Sbjct: 55  PGRPRPRAPPAASRLPASAPLFMLDLYHAMAGDDDEDGAPA-----ERRLGRADLVMSFV 109

Query: 114 HEESLEELPETSGKTTRRFFFNLSSIPTEEFITSAELQVFREQMQDALGNNSSFHHRINI 173
           +    +          + F F+L+ IP  E +T+AE ++++      L  N + H  +++
Sbjct: 110 NMVERDRALGHQEPHWKEFRFDLTQIPAGEAVTAAEFRIYKVPSIHLL--NRTLH--VSM 165

Query: 174 YEIIKPATANSKFPVTRLLDTRLVNQNASRWESFDVTPAVMRWTAQGHANHGFVVEVAHL 233
           +++++  +  ++      LD + +      W   DVT A   W  + H + G  +   ++
Sbjct: 166 FQVVQEQS--NRESDLFFLDLQTLRAGDEGWLVLDVTAASDCWLLKRHKDLGLRL---YV 220

Query: 234 EEKQGVSKRHVRISRSLHQDEHSWSQIRPLLVTFGHDGKG--------HPLHKREKRQAK 285
           E + G S     ++  L Q      Q  P +VTF               PL +R+ +++ 
Sbjct: 221 ETEDGHSV-DPGLAGLLGQRAPRSQQ--PFVVTFFRASPSPIRTPRAVRPLRRRQPKKSN 277

Query: 286 H-KQRKRL------------KSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFP 332
              Q  RL            +  C+RH LYV F D+GW DW++AP GY A+YC GEC FP
Sbjct: 278 ELPQANRLPGIFDDVHGSHGRQVCRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFP 337

Query: 333 LADHLNSTNHAIVQTLVN-SVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVE 391
           L   +N+TNHAI+Q+LV+  +   +PKACC PT+LSA S+LY D +  V+L+ +++MVV+
Sbjct: 338 LDSCMNATNHAILQSLVHLMMPDAVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVK 397

Query: 392 GCGC 395
            CGC
Sbjct: 398 ACGC 401


>gi|145611428 bone morphogenetic protein 8A [Homo sapiens]
          Length = 402

 Score =  170 bits (431), Expect = 2e-42
 Identities = 130/424 (30%), Positives = 204/424 (48%), Gaps = 60/424 (14%)

Query: 4   GTRCLLALLLPQVLLGGAAGLVPELGRRKFAAASSGRPSSQPSDEVLSEFELRLLSMFGL 63
           G   LL L L   L GG  GL P            G P  +       + +  +L++ GL
Sbjct: 6   GPLWLLGLTLC-ALGGGGPGLRPP----------PGCPQRRLGARERRDVQREILAVLGL 54

Query: 64  KQRPTPSRD-------AVVPPYMLDLYRRHSG---QPGSPAPDHRLERAASRANTVRSFH 113
             RP P          A  P +MLDLY   +G   + G+PA     E+   RA+ V SF 
Sbjct: 55  PGRPRPRAPPAASRLPASAPLFMLDLYHAMAGDDDEDGAPA-----EQRLGRADLVMSFV 109

Query: 114 HEESLEELPETSGKTTRRFFFNLSSIPTEEFITSAELQVFREQMQDALGNNSSFHHRINI 173
           +    +          + F F+L+ IP  E +T+AE ++++      L  N + H  +++
Sbjct: 110 NMVERDRALGHQEPHWKEFRFDLTQIPAGEAVTAAEFRIYKVPSIHLL--NRTLH--VSM 165

Query: 174 YEIIKPATANSKFPVTRLLDTRLVNQNASRWESFDVTPAVMRWTAQGHANHGFVVEVAHL 233
           +++++  +  ++      LD + +      W   DVT A   W  + H + G  +   ++
Sbjct: 166 FQVVQEQS--NRESDLFFLDLQTLRAGDEGWLVLDVTAASDCWLLKRHKDLGLRL---YV 220

Query: 234 EEKQGVSKRHVRISRSLHQDEHSWSQIRPLLVTFGHDGKG--------HPLHKREKRQAK 285
           E + G S     ++  L Q      Q  P +VTF               PL +R+ +++ 
Sbjct: 221 ETEDGHSV-DPGLAGLLGQRAPRSQQ--PFVVTFFRASPSPIRTPRAVRPLRRRQPKKSN 277

Query: 286 H-KQRKRL------------KSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFP 332
              Q  RL            +  C+RH LYV F D+GW DW++AP GY A+YC GEC FP
Sbjct: 278 ELPQANRLPGIFDDVRGSHGRQVCRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFP 337

Query: 333 LADHLNSTNHAIVQTLVNSVN-SKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVE 391
           L   +N+TNHAI+Q+LV+ +  + +PKACC PT+LSA S+LY D +  V+L+ +++MVV+
Sbjct: 338 LDSCMNATNHAILQSLVHLMKPNAVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVK 397

Query: 392 GCGC 395
            CGC
Sbjct: 398 ACGC 401


>gi|10190670 growth differentiation factor 3 precursor [Homo
           sapiens]
          Length = 364

 Score =  155 bits (392), Expect = 6e-38
 Identities = 112/359 (31%), Positives = 178/359 (49%), Gaps = 38/359 (10%)

Query: 54  ELRLLSMFGLKQRPTPSRDAVVPPYMLDLY--RRHSGQPGSPAPDHRLERAASRANTVRS 111
           E   L   GL + P+P +   VP  +  ++  R  +   G       ++    R N +R 
Sbjct: 26  EYVFLQFLGLDKAPSPQKFQPVPYILKKIFQDREAAATTGVSRDLCYVKELGVRGNVLRF 85

Query: 112 FHHEESL---EELPETSGKTTRRFFFNLSSIPTEEFITSAELQVFREQMQDALGNNSSFH 168
              +      +++ + S    +  +FNLS+I   E +T A+L +        LG NS ++
Sbjct: 86  LPDQGFFLYPKKISQASSCLQKLLYFNLSAIKEREQLTLAQLGL-------DLGPNSYYN 138

Query: 169 H----RINIYEIIKPATANSKFPVT-RLLDTRLVN--QNASRWESFDVTPAVMRWTAQGH 221
                 + ++ + +P       P   ++   R V   Q A  +   DV      W     
Sbjct: 139 LGPELELALFLVQEPHVWGQTTPKPGKMFVLRSVPWPQGAVHFNLLDVAKD---WNDNPR 195

Query: 222 ANHGFVVEVAHLEEKQ-GVSKRH----VRISRSLHQDEHSWSQIRPLLVTFGHDGKGHPL 276
            N G  +E+   E++  GV+ +      R+  SLH           LLV   +  + HP 
Sbjct: 196 KNFGLFLEILVKEDRDSGVNFQPEDTCARLRCSLHAS---------LLVVTLNPDQCHPS 246

Query: 277 HKREKRQAKHKQRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADH 336
            KR  R A    +   K+ C RH L+++F D+GW+ WI+AP G+ A YCHGECPF L   
Sbjct: 247 RKR--RAAIPVPKLSCKNLCHRHQLFINFRDLGWHKWIIAPKGFMANYCHGECPFSLTIS 304

Query: 337 LNSTNHAIVQTLVNSVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGC 395
           LNS+N+A +Q L+++V+ +IP+A C+PT+LS ISMLY D N+ V+L++Y+DMVV+ CGC
Sbjct: 305 LNSSNYAFMQALMHAVDPEIPQAVCIPTKLSPISMLYQDNNDNVILRHYEDMVVDECGC 363


>gi|4503969 growth differentiation factor 5 preproprotein [Homo
           sapiens]
          Length = 501

 Score =  154 bits (390), Expect = 1e-37
 Identities = 122/391 (31%), Positives = 179/391 (45%), Gaps = 52/391 (13%)

Query: 39  GRPSSQPSDEVLSEFELRLLSMFGLKQRPT-PSRDAVVPP--YMLDLYRRHSGQPGSPAP 95
           G  +   +  V S F L+     G  + P  P R   + P  YML LYR  S        
Sbjct: 130 GGKAPPKAGSVPSSFLLKKAREPGPPREPKEPFRPPPITPHEYMLSLYRTLS-DADRKGG 188

Query: 96  DHRLERAASRANTVRSFHHEESLEELPETSGKTTR--RFFFNLSSIPTEEFITSAELQVF 153
           +  ++  A  ANT+ SF     +++  +  G   R  R+ F++S++  +  +  AEL++ 
Sbjct: 189 NSSVKLEAGLANTITSF-----IDKGQDDRGPVVRKQRYVFDISALEKDGLL-GAELRIL 242

Query: 154 REQMQDALGNNSSFHHRINIYEIIKPATANSKFPVTRLLDTRLV-NQNASRWESFDVTPA 212
           R++  D     +    R      +K ++  S      LLD R V   + S WE FD+   
Sbjct: 243 RKKPSDTAKPAAPGGGRA---AQLKLSSCPSGRQPASLLDVRSVPGLDGSGWEVFDIWKL 299

Query: 213 VMRWTAQGHANHGFVVEVAHLEEKQGVSKRHVRISRSLHQDEHSWSQIRPLLVTFGHDGK 272
              +           +E+   E  + V  R +   R+  Q        + L + FG   K
Sbjct: 300 FRNFKNSAQ----LCLELEAWERGRAVDLRGLGFDRAARQVHE-----KALFLVFGRTKK 350

Query: 273 G--------------------HPLHKREKRQAKHKQR------KRLKSSCKRHPLYVDFS 306
                                +   +R KR+A    R      K LK+ C R  L+V+F 
Sbjct: 351 RDLFFNEIKARSGQDDKTVYEYLFSQRRKRRAPLATRQGKRPSKNLKARCSRKALHVNFK 410

Query: 307 DVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVN-SKIPKACCVPTE 365
           D+GW+DWI+AP  Y AF+C G C FPL  HL  TNHA++QTL+NS++    P  CCVPT 
Sbjct: 411 DMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTR 470

Query: 366 LSAISMLYLDENEKVVLKNYQDMVVEGCGCR 396
           LS IS+L++D    VV K Y+DMVVE CGCR
Sbjct: 471 LSPISILFIDSANNVVYKQYEDMVVESCGCR 501


>gi|61835232 growth differentiation factor 7 preproprotein [Homo
           sapiens]
          Length = 450

 Score =  150 bits (379), Expect = 2e-36
 Identities = 121/382 (31%), Positives = 176/382 (46%), Gaps = 74/382 (19%)

Query: 73  AVVPP-YMLDLYRRHSGQPGSPAPDHRLERAAS---RANTVRSFHHEESLEELPETSGKT 128
           +VVP  +M+ LYR  +G+    AP      +AS   RA+T+  F  + + +E   ++ +T
Sbjct: 85  SVVPHHFMMSLYRSLAGR----APAGAAAVSASGHGRADTITGFTDQATQDE---SAAET 137

Query: 129 TRRFFFNLSSIPTEEFITSAELQVFREQMQDALGNNSSFHHRINIYEIIKPATANSKFPV 188
            + F F++SS+   + +  AEL+V R       G+  S         ++  +T       
Sbjct: 138 GQSFLFDVSSLNDADEVVGAELRVLRR------GSPESGPGSWTSPPLLLLSTCPGAARA 191

Query: 189 TRLLDTR----LVNQNASRWESFDVTPAVMRWTAQGHANHGFVVEVAHLEEK-------- 236
            RLL +R    LV Q   RWE+FDV  A+ R   +      F + +  +           
Sbjct: 192 PRLLYSRAAEPLVGQ---RWEAFDVADAMRRHRREPRPPRAFCLLLRAVAGPVPSPLALR 248

Query: 237 -----------QGVSKRHVRISRSLHQDEHS-WSQIRPLLVTFGHDGKGHPLH------- 277
                          +R V +  S  Q + S + +IR      G      PL        
Sbjct: 249 RLGFGWPGGGGSAAEERAVLVVSSRTQRKESLFREIRAQARALGAALASEPLPDPGTGTA 308

Query: 278 --------KREKRQAKHKQR--------------KRLKSSCKRHPLYVDFSDVGWNDWIV 315
                   +R +R A    R              +R +S C R PL+VDF ++GW+DWI+
Sbjct: 309 SPRAVIGGRRRRRTALAGTRTAQGSGGGAGRGHGRRGRSRCSRKPLHVDFKELGWDDWII 368

Query: 316 APPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSV-NSKIPKACCVPTELSAISMLYL 374
           AP  Y A++C G C FPL  HL  TNHAI+QTL+NS+     P +CCVP  LS IS+LY+
Sbjct: 369 APLDYEAYHCEGLCDFPLRSHLEPTNHAIIQTLLNSMAPDAAPASCCVPARLSPISILYI 428

Query: 375 DENEKVVLKNYQDMVVEGCGCR 396
           D    VV K Y+DMVVE CGCR
Sbjct: 429 DAANNVVYKQYEDMVVEACGCR 450


>gi|7705308 growth differentiation factor 2 [Homo sapiens]
          Length = 429

 Score =  144 bits (362), Expect = 2e-34
 Identities = 116/381 (30%), Positives = 173/381 (45%), Gaps = 57/381 (14%)

Query: 55  LRLLSMFGLKQRPTPSRDAVVPP-YMLDLYRRH-SGQPGSPAPDHRLERAASRANTVRSF 112
           LR L++ G+   P+  +  V PP YM+DLY R+ S +  +PA           +N VRSF
Sbjct: 67  LRSLNLSGV---PSQDKTRVEPPQYMIDLYNRYTSDKSTTPA-----------SNIVRSF 112

Query: 113 HHEESLEELPETSGKTTRRFFFNLSSIPTEEFITSAELQVFREQMQDALGNNSSFHHRIN 172
             E+++           +       SIP  E IT AEL+++    Q+ +  +      + 
Sbjct: 113 SMEDAISITATEDFPFQKHILLFNISIPRHEQITRAELRLY-VSCQNHVDPSHDLKGSVV 171

Query: 173 IYEIIKPATANSKFPVTRLLDTRLVNQNASR--WESFDVTPAVMRWTAQGHANHGFVVEV 230
           IY+++    A      T+   T LV+Q+     WE+ +V+ AV RW           +EV
Sbjct: 172 IYDVLDGTDAWDSATETK---TFLVSQDIQDEGWETLEVSSAVKRWVRSDSTKSKNKLEV 228

Query: 231 AHLEEKQGVSKRHVRI---SRSL----------------------HQDEHSWSQIRPLLV 265
                ++G     + +   SR+L                          H    +   L 
Sbjct: 229 TVESHRKGCDTLDISVPPGSRNLPFFVVFSNDHSSGTKETRLELREMISHEQESVLKKLS 288

Query: 266 TFGHDGKGHPLHKRE--------KRQAKHKQRKRLKSSCKRHPLYVDFSDVGWNDWIVAP 317
             G    G   H+ +           A+ K+     S C++  L V+F D+GW+ WI+AP
Sbjct: 289 KDGSTEAGESSHEEDTDGHVAAGSTLARRKRSAGAGSHCQKTSLRVNFEDIGWDSWIIAP 348

Query: 318 PGYHAFYCHGECPFPLADHLNSTNHAIVQTLVN-SVNSKIPKACCVPTELSAISMLYLDE 376
             Y A+ C G C FPLAD +  T HAIVQTLV+    +K+ KACCVPT+LS IS+LY D+
Sbjct: 349 KEYEAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISVLYKDD 408

Query: 377 NEKVVLK-NYQDMVVEGCGCR 396
                LK +Y+ M V  CGCR
Sbjct: 409 MGVPTLKYHYEGMSVAECGCR 429


>gi|48475062 growth differentiation factor 6 precursor [Homo
           sapiens]
          Length = 455

 Score =  139 bits (349), Expect = 6e-33
 Identities = 60/113 (53%), Positives = 83/113 (73%), Gaps = 3/113 (2%)

Query: 285 KHKQRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAI 344
           +H ++ RL+  C + PL+V+F ++GW+DWI+AP  Y A++C G C FPL  HL  TNHAI
Sbjct: 345 RHGKKSRLR--CSKKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPLRSHLEPTNHAI 402

Query: 345 VQTLVNSVN-SKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR 396
           +QTL+NS++    P +CCVPT+L+ IS+LY+D    VV K Y+DMVVE CGCR
Sbjct: 403 IQTLMNSMDPGSTPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVVESCGCR 455



 Score = 38.9 bits (89), Expect = 0.008
 Identities = 39/149 (26%), Positives = 69/149 (46%), Gaps = 18/149 (12%)

Query: 65  QRPTPSRDAVVP-PYMLDLYRRHSGQPGSPAPDHRLERAASRANTVRSFHHEESLEELPE 123
           Q P      VVP  YML +YR +S        +    +++  ANT+ SF  +  L++L  
Sbjct: 83  QEPPGRGPRVVPHEYMLSIYRTYSIAE-KLGINASFFQSSKSANTITSFV-DRGLDDLSH 140

Query: 124 TSGKTTRRFFFNLSSIPTEEFITSAELQVFREQMQDALGNNSSFHHRINIYEIIKPATAN 183
           T  +  +++ F++S +  +E +  AEL++FR+      G  +   H + ++  + P    
Sbjct: 141 TPLRR-QKYLFDVSMLSDKEELVGAELRLFRQAPSAPWGPPAGPLH-VQLFPCLSPL--- 195

Query: 184 SKFPVTRLLDTRLVNQNA---SRWESFDV 209
                  LLD R ++      + WE FDV
Sbjct: 196 -------LLDARTLDPQGAPPAGWEVFDV 217


>gi|4504699 inhibin beta A precursor [Homo sapiens]
          Length = 426

 Score =  122 bits (307), Expect = 4e-28
 Identities = 106/426 (24%), Positives = 174/426 (40%), Gaps = 89/426 (20%)

Query: 26  PELGRRKFAAASSGRPSSQPSDEVLSEFELRLLSMFGLKQRPTPSRDAVVPPYMLDLYRR 85
           P+      AA     P+SQP  E++   +  +L+M  LK+RP  ++       +  + + 
Sbjct: 33  PDCPSCALAALPKDVPNSQP--EMVEAVKKHILNMLHLKKRPDVTQPVPKAALLNAIRKL 90

Query: 86  HSGQPGSPAPDHRLERAASRANTVRSFHHEESLEELPETSGKTTRRFFFNLSSIPTEEFI 145
           H G+ G                       E    E+ +  G   RR   N     T E I
Sbjct: 91  HVGKVG-----------------------ENGYVEIEDDIG---RRAEMNELMEQTSEII 124

Query: 146 TSAELQVFREQMQDAL---GNNSSFHHRINIYEIIKPATAN-SKFPVT------------ 189
           T AE    R+ +   +   G++ S   R  ++  +K   AN ++  VT            
Sbjct: 125 TFAESGTARKTLHFEISKEGSDLSVVERAEVWLFLKVPKANRTRTKVTIRLFQQQKHPQG 184

Query: 190 -------------------RLLDTRLVNQNASRWESFDVTPAVMRWTAQGHANHGFVVEV 230
                               LL  ++V+   S W  F V+ ++ R   QG ++    +  
Sbjct: 185 SLDTGEEAEEVGLKGERSELLLSEKVVDARKSTWHVFPVSSSIQRLLDQGKSSLDVRIAC 244

Query: 231 AHLEE---------------KQGVSKRHVRISRSLHQDEHSWSQIRPLLVTFGHDGKGHP 275
              +E               ++G  K+          DE      RP L+      + HP
Sbjct: 245 EQCQESGASLVLLGKKKKKEEEGEGKKKGGGEGGAGADEEKEQSHRPFLMLQARQSEDHP 304

Query: 276 LHKREKRQAKHKQRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLAD 335
            H+R +R  +   +  +   C +   +V F D+GWNDWI+AP GYHA YC GECP  +A 
Sbjct: 305 -HRRRRRGLECDGKVNI---CCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAG 360

Query: 336 HLNSTNHAIVQTLVNSVNSK------IPKACCVPTELSAISMLYLDENEKVVLKNYQDMV 389
             + ++ +   T++N    +        K+CCVPT+L  +SMLY D+ + ++ K+ Q+M+
Sbjct: 361 -TSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMI 419

Query: 390 VEGCGC 395
           VE CGC
Sbjct: 420 VEECGC 425


>gi|126507087 bone morphogenetic protein 3 preproprotein [Homo
           sapiens]
          Length = 472

 Score =  119 bits (297), Expect = 6e-27
 Identities = 54/132 (40%), Positives = 85/132 (64%), Gaps = 3/132 (2%)

Query: 268 GHDGKGHPLHKREKRQAKHKQRKRLKS-SCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCH 326
           G   K   L   E+   K ++++ ++  +C R  L VDF+D+GW++WI++P  + A+YC 
Sbjct: 341 GPHRKSQTLQFDEQTLKKARRKQWIEPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCS 400

Query: 327 GECPFPLADHLNSTNHAIVQTLVNSVN--SKIPKACCVPTELSAISMLYLDENEKVVLKN 384
           G C FP+   L  +NHA +Q++V +V     IP+ CCVP ++S++S+L+ DEN+ VVLK 
Sbjct: 401 GACQFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKV 460

Query: 385 YQDMVVEGCGCR 396
           Y +M VE C CR
Sbjct: 461 YPNMTVESCACR 472


>gi|4826740 growth differentiation factor 10 precursor [Homo
           sapiens]
          Length = 478

 Score =  113 bits (283), Expect = 3e-25
 Identities = 47/103 (45%), Positives = 71/103 (68%), Gaps = 2/103 (1%)

Query: 296 CKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVN-- 353
           C R  L VDF+D+GWN+WI++P  + A+YC G C FP+   +  +NHA +Q++V +V   
Sbjct: 376 CSRRYLKVDFADIGWNEWIISPKSFDAYYCAGACEFPMPKIVRPSNHATIQSIVRAVGII 435

Query: 354 SKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR 396
             IP+ CCVP +++++ +L+LDEN  VVLK Y +M V+ C CR
Sbjct: 436 PGIPEPCCVPDKMNSLGVLFLDENRNVVLKVYPNMSVDTCACR 478



 Score = 30.4 bits (67), Expect = 2.9
 Identities = 26/87 (29%), Positives = 38/87 (43%), Gaps = 17/87 (19%)

Query: 69  PSRDAVVPPYMLDLYRRHSGQPGSPAPDHRLERAASRANTVRSFHHEESLEELPETSGKT 128
           PS   +V  +M  LY ++S Q   P             NTVRSF     LE + + +   
Sbjct: 69  PSAQDMVAVHMHRLYEKYSRQGARPGG----------GNTVRSFRAR--LEVVDQKAV-- 114

Query: 129 TRRFFFNLSSIPTEEFITSAELQVFRE 155
              +FFNL+S+   E I +A    + E
Sbjct: 115 ---YFFNLTSMQDSEMILTATFHFYSE 138


>gi|154813204 inhibin beta B subunit preproprotein [Homo sapiens]
          Length = 407

 Score =  105 bits (261), Expect = 9e-23
 Identities = 88/355 (24%), Positives = 148/355 (41%), Gaps = 28/355 (7%)

Query: 48  EVLSEFELRLLSMFGLKQRPTPSRDAVVPPYMLDLYRRHSG---QPGSPAPDHRLERAAS 104
           + L   +  +LS   ++ RP  +        +  L + H+G   + G     H    A+ 
Sbjct: 73  DFLEAVKRHILSRLQMRGRPNITHAVPKAAMVTALRKLHAGKVREDGRVEIPHLDGHASP 132

Query: 105 RANTVRSFHHEESLEELPETSGKTTRRFFFNLSSIPTEEFITSAELQVFREQMQDALGNN 164
            A+         S  E    +    R +FF  +      F+  A L ++ + +   L   
Sbjct: 133 GADGQERVSEIISFAETDGLASSRVRLYFFISNEGNQNLFVVQASLWLYLKLLPYVLEKG 192

Query: 165 SSFHHRINIYEIIKPATANSKFPVTRLLDTRLVNQNASRWESFDVTPAVMRWTAQGHANH 224
           S    R+ +Y   +      ++ +      + V+   S W +F +T A+     +G    
Sbjct: 193 SRRKVRVKVY--FQEQGHGDRWNMVE----KRVDLKRSGWHTFPLTEAIQALFERGERRL 246

Query: 225 GFVVEVAHLEEKQGVSKRHVRISRSLHQDEHSWSQIRPLLVTFGHDGKGHPLHKREKRQA 284
              V+    +E   V      +     ++ H     RP +V     G     H+  KR  
Sbjct: 247 NLDVQCDSCQELAVVP-----VFVDPGEESH-----RPFVVVQARLGDSR--HRIRKRGL 294

Query: 285 KHKQRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLA---DHLNSTN 341
           +   R  L   C R   ++DF  +GWNDWI+AP GY+  YC G CP  LA      +S +
Sbjct: 295 ECDGRTNL---CCRQQFFIDFRLIGWNDWIIAPTGYYGNYCEGSCPAYLAGVPGSASSFH 351

Query: 342 HAIV-QTLVNSVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGC 395
            A+V Q  +  +N     +CC+PT+LS +SMLY D+   +V ++  +M+VE CGC
Sbjct: 352 TAVVNQYRMRGLNPGTVNSCCIPTKLSTMSMLYFDDEYNIVKRDVPNMIVEECGC 406


>gi|222352098 nodal precursor [Homo sapiens]
          Length = 347

 Score =  103 bits (258), Expect = 2e-22
 Identities = 46/116 (39%), Positives = 71/116 (61%), Gaps = 3/116 (2%)

Query: 281 KRQAKHKQRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNST 340
           KR  +H    R    C++    VDF+ +GW  WI+ P  Y+A+ C GECP P+ +  + T
Sbjct: 233 KRHRRHHLPDR-SQLCRKVKFQVDFNLIGWGSWIIYPKQYNAYRCEGECPNPVGEEFHPT 291

Query: 341 NHAIVQTLVNSVN-SKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGC 395
           NHA +Q+L+      ++P  CC P +   +SMLY+D N +V+L +++DM+VE CGC
Sbjct: 292 NHAYIQSLLKRYQPHRVPSTCCAPVKTKPLSMLYVD-NGRVLLDHHKDMIVEECGC 346


>gi|4885097 bone morphogenetic protein 15 precursor [Homo sapiens]
          Length = 392

 Score =  102 bits (253), Expect = 8e-22
 Identities = 44/104 (42%), Positives = 62/104 (59%), Gaps = 1/104 (0%)

Query: 294 SSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNS-V 352
           + C  HP  + F  +GW+ WI+APP Y   YC G C   L D LNS NHAI+Q L+N  V
Sbjct: 289 NQCSLHPFQISFRQLGWDHWIIAPPFYTPNYCKGTCLRVLRDGLNSPNHAIIQNLINQLV 348

Query: 353 NSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR 396
           +  +P+  CVP +   IS+L ++ N  ++ K Y+ M+ E C CR
Sbjct: 349 DQSVPRPSCVPYKYVPISVLMIEANGSILYKEYEGMIAESCTCR 392


>gi|110349792 growth differentiation factor 1 [Homo sapiens]
          Length = 372

 Score =  101 bits (252), Expect = 1e-21
 Identities = 52/130 (40%), Positives = 80/130 (61%), Gaps = 10/130 (7%)

Query: 274 HPLHKREKRQAKHKQRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPL 333
           HPL  R +R A+         +C+   LYV F +VGW+ W++AP G+ A YC G+C  P+
Sbjct: 246 HPL-ARPRRDAEPVLGGGPGGACRARRLYVSFREVGWHRWVIAPRGFLANYCQGQCALPV 304

Query: 334 ADHLN----STNHAIVQTLVNSVN---SKIPKACCVPTELSAISMLYLDENEKVVLKNYQ 386
           A   +    + NHA+++ L+++     + +P  CCVP  LS IS+L+ D ++ VVL+ Y+
Sbjct: 305 ALSGSGGPPALNHAVLRALMHAAAPGAADLP--CCVPARLSPISVLFFDNSDNVVLRQYE 362

Query: 387 DMVVEGCGCR 396
           DMVV+ CGCR
Sbjct: 363 DMVVDECGCR 372


>gi|13899338 activin beta E [Homo sapiens]
          Length = 350

 Score = 99.8 bits (247), Expect = 4e-21
 Identities = 64/170 (37%), Positives = 84/170 (49%), Gaps = 10/170 (5%)

Query: 235 EKQGVSKRHVRISRSLHQDEHSWSQIRPLLVTFGHDGKGHPLHKREKRQAKHKQRKRLKS 294
           EK GV K  +   R L  +     Q R LL T GH      L  R       + R+R  +
Sbjct: 181 EKSGVLKLQLDC-RPLEGNSTVTGQPRRLLDTAGHQQPFLELKIRANEPGAGRARRRTPT 239

Query: 295 S------CKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADH--LNSTNHAIVQ 346
                  C R   YVDF ++GW DWI+ P GY   YC G+CP  LA    + ++ H+ V 
Sbjct: 240 CEPATPLCCRRDHYVDFQELGWRDWILQPEGYQLNYCSGQCPPHLAGSPGIAASFHSAVF 299

Query: 347 TLVNSVNS-KIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGC 395
           +L+ + N      +CCVPT    +S+LYLD N  VV  +  DMVVE CGC
Sbjct: 300 SLLKANNPWPASTSCCVPTARRPLSLLYLDHNGNVVKTDVPDMVVEACGC 349


>gi|4885259 myostatin [Homo sapiens]
          Length = 375

 Score = 98.6 bits (244), Expect = 9e-21
 Identities = 97/368 (26%), Positives = 148/368 (40%), Gaps = 68/368 (18%)

Query: 50  LSEFELRLLSMFGLKQRPTPSRDAV------VPPY--MLDLY--RRHSGQPGSPAPDHRL 99
           +   ++++LS   L+  P  S+D +       PP   ++D Y  +R     GS      L
Sbjct: 53  IEAIKIQILSKLRLETAPNISKDVIRQLLPKAPPLRELIDQYDVQRDDSSDGS------L 106

Query: 100 ERAASRANTVRSFHHEESLEELPETSGKTTRRFFFNLSSIPTEEFITSAELQVFREQMQD 159
           E     A T          + L +  GK  +  FF  SS      +  A+L ++   ++ 
Sbjct: 107 EDDDYHATTETIITMPTESDFLMQVDGKP-KCCFFKFSSKIQYNKVVKAQLWIYLRPVET 165

Query: 160 ALGNNSSFHHRINIYEIIKPATANSKFPVTRLLDTRLVNQNASRWESFDVTPAVMRWTAQ 219
                + F   + I  +IKP    +++   R L   + N     W+S DV   +  W  Q
Sbjct: 166 P---TTVF---VQILRLIKPMKDGTRYTGIRSLKLDM-NPGTGIWQSIDVKTVLQNWLKQ 218

Query: 220 GHANHGFVVEVAHLEEKQGVSKRHVRISRSLHQDEHSWSQIRPLLVTF---GHDGKGHPL 276
             +N G  +                   ++L ++ H       L VTF   G DG    L
Sbjct: 219 PESNLGIEI-------------------KALDENGHD------LAVTFPGPGEDGLNPFL 253

Query: 277 HKREKRQAKHKQRK--------RLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGE 328
             +     K  +R           +S C R+PL VDF   GW DWI+AP  Y A YC GE
Sbjct: 254 EVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGW-DWIIAPKRYKANYCSGE 312

Query: 329 CPFPLADHLNSTNHAIVQTLVNSVNSKIPKA-CCVPTELSAISMLYLDENEKVVLKNYQD 387
           C F        T+      LV+  N +     CC PT++S I+MLY +  E+++      
Sbjct: 313 CEFVFLQKYPHTH------LVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPA 366

Query: 388 MVVEGCGC 395
           MVV+ CGC
Sbjct: 367 MVVDRCGC 374


>gi|5031795 inhibin beta C chain preproprotein [Homo sapiens]
          Length = 352

 Score = 97.4 bits (241), Expect = 2e-20
 Identities = 95/391 (24%), Positives = 155/391 (39%), Gaps = 48/391 (12%)

Query: 10  ALLLPQVLLGGAAGLVPELGRRKFAAASSGRPSSQPSDEVLSEFELRLLSMFGLKQRPTP 69
           +LLL  +LL       P  G +  A            + +L   +  +L    L QRPT 
Sbjct: 4   SLLLAFLLLAPTTVATPRAGGQCPACGGPTLELESQRELLLDLAKRSILDKLHLTQRPTL 63

Query: 70  SRDAVVPPYMLDLYRRHSGQPGSPAPDHRLERAASRANTVRSFHHEESLEELPETSGKTT 129
           +R          L   H    G+   D+R +        + SF      E    T  +T 
Sbjct: 64  NRPVSRAALRTALQHLHGVPQGALLEDNREQECE-----IISF-----AETGLSTINQTR 113

Query: 130 RRFFFNLSSIPTEEFITSAELQVFREQMQDALGNNSSFHHRINIYEIIKPATANSKFPVT 189
             F F+      +  +  A L  F +     L +N+++  ++ +  ++ P   N      
Sbjct: 114 LDFHFSSDRTAGDREVQQASLMFFVQ-----LPSNTTWTLKVRVL-VLGPHNTNLTLATQ 167

Query: 190 RLLDTRLVNQNASRWESFDVTPAVMRWTAQGHANHGFVVEVAHLEEKQGVSKRHVRISRS 249
            LL+      +AS W    + P      +QGH     V+E         V++  V +  +
Sbjct: 168 YLLEV-----DASGWHQLPLGPEAQAACSQGHLTLELVLEGQ-------VAQSSVILGGA 215

Query: 250 LHQDEHSWSQIRPLLVTFGHDGKGHPLHKREKRQAKHKQRKRLKSSCKRHPLYVDFSDVG 309
            H         RP +      G  H +H+R       +   R+   C R   +VDF ++G
Sbjct: 216 AH---------RPFVAARVRVGGKHQIHRRG---IDCQGGSRM---CCRQEFFVDFREIG 260

Query: 310 WNDWIVAPPGYHAFYCHGECPFPLA--DHLNSTNHAIVQTLV---NSVNSKIPKACCVPT 364
           W+DWI+ P GY   +C G+CP  +A    + ++ H  V  L+    +  +    +CCVPT
Sbjct: 261 WHDWIIQPEGYAMNFCIGQCPLHIAGMPGIAASFHTAVLNLLKANTAAGTTGGGSCCVPT 320

Query: 365 ELSAISMLYLDENEKVVLKNYQDMVVEGCGC 395
               +S+LY D +  +V  +  DMVVE CGC
Sbjct: 321 ARRPLSLLYYDRDSNIVKTDIPDMVVEACGC 351


>gi|4507465 transforming growth factor, beta 3 [Homo sapiens]
          Length = 412

 Score = 93.6 bits (231), Expect = 3e-19
 Identities = 96/382 (25%), Positives = 164/382 (42%), Gaps = 58/382 (15%)

Query: 56  RLLSMFGLKQRPTPSRDAVVPPYMLDLYRRHSGQPGSPAPDHRLERAASRANT-----VR 110
           ++LS   L   P P+    VP  +L LY  +S +          E   ++ NT      +
Sbjct: 46  QILSKLRLTSPPEPTVMTHVPYQVLALY--NSTRELLEEMHGEREEGCTQENTESEYYAK 103

Query: 111 SFHHEESLEELPETS-------GKTTRRFFFNLSSIPTEEF-ITSAELQVFREQMQDALG 162
             H  + ++ L E +       G T++ F FN+SS+      +  AE +V R     +  
Sbjct: 104 EIHKFDMIQGLAEHNELAVCPKGITSKVFRFNVSSVEKNRTNLFRAEFRVLRVPNPSSKR 163

Query: 163 NNSSFHHRINIYEIIKPAT--ANSKFPVTRLLDTRLVNQNASRWESFDVTPAVMRWTAQG 220
           N      RI +++I++P    A  ++   + L TR      + W SFDVT  V  W  + 
Sbjct: 164 NEQ----RIELFQILRPDEHIAKQRYIGGKNLPTR----GTAEWLSFDVTDTVREWLLRR 215

Query: 221 HANHGFVVEV---AHLEEKQGVSKRHVRISRSL------HQDEHSWSQIRPLLVTFGHDG 271
            +N G  + +    H  +  G    ++     +      ++D+H    +  L     H  
Sbjct: 216 ESNLGLEISIHCPCHTFQPNGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHN 275

Query: 272 KGH-----PLHKREKRQAKHKQRKR----------LKSSCKRHPLYVDF-SDVGWNDWIV 315
                   P H+ +      +++KR          L+ +C   PLY+DF  D+GW  W+ 
Sbjct: 276 PHLILMMIPPHRLDNPGQGGQRKKRALDTNYCFRNLEENCCVRPLYIDFRQDLGWK-WVH 334

Query: 316 APPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNSKIPKA-CCVPTELSAISML-Y 373
            P GY+A +C G CP+  +     T H+ V  L N++N +   + CCVP +L  +++L Y
Sbjct: 335 EPKGYYANFCSGPCPYLRS---ADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYY 391

Query: 374 LDENEKVVLKNYQDMVVEGCGC 395
           +    KV  +   +MVV+ C C
Sbjct: 392 VGRTPKV--EQLSNMVVKSCKC 411


>gi|208022653 transforming growth factor, beta 2 isoform 1 [Homo
           sapiens]
          Length = 442

 Score = 89.0 bits (219), Expect = 7e-18
 Identities = 77/283 (27%), Positives = 125/283 (44%), Gaps = 45/283 (15%)

Query: 145 ITSAELQVFREQMQDALGNNSSFHHRINIYEIIKPATANSKFPVTRLLDTRLVNQNAS-R 203
           +  AE +VFR Q   A         RI +Y+I+K     S  P  R +D+++V   A   
Sbjct: 172 LVKAEFRVFRLQNPKARVPEQ----RIELYQILKSKDLTS--PTQRYIDSKVVKTRAEGE 225

Query: 204 WESFDVTPAVMRWTAQGHANHGFVVEVAHLEEKQGVSKRHVRISRSLHQDEHSWSQIRPL 263
           W SFDVT AV  W      N GF + + H      V   +  I     + E  ++ I   
Sbjct: 226 WLSFDVTDAVHEWLHHKDRNLGFKISL-HCPCCTFVPSNNYIIPNKSEELEARFAGIDGT 284

Query: 264 LVTFGHDGKGH-------------------PLHKREKRQAKHKQRKRL---------KSS 295
                 D K                     P ++ E +Q   ++++ L         + +
Sbjct: 285 STYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDN 344

Query: 296 CKRHPLYVDFS-DVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNS 354
           C   PLY+DF  D+GW  WI  P GY+A +C G CP+  +   + T H+ V +L N++N 
Sbjct: 345 CCLRPLYIDFKRDLGWK-WIHEPKGYNANFCAGACPYLWS---SDTQHSRVLSLYNTINP 400

Query: 355 KIPKA-CCVPTELSAISML-YLDENEKVVLKNYQDMVVEGCGC 395
           +   + CCV  +L  +++L Y+ +  K+  +   +M+V+ C C
Sbjct: 401 EASASPCCVSQDLEPLTILYYIGKTPKI--EQLSNMIVKSCKC 441


>gi|4507463 transforming growth factor, beta 2 isoform 2 [Homo
           sapiens]
          Length = 414

 Score = 89.0 bits (219), Expect = 7e-18
 Identities = 77/283 (27%), Positives = 125/283 (44%), Gaps = 45/283 (15%)

Query: 145 ITSAELQVFREQMQDALGNNSSFHHRINIYEIIKPATANSKFPVTRLLDTRLVNQNAS-R 203
           +  AE +VFR Q   A         RI +Y+I+K     S  P  R +D+++V   A   
Sbjct: 144 LVKAEFRVFRLQNPKARVPEQ----RIELYQILKSKDLTS--PTQRYIDSKVVKTRAEGE 197

Query: 204 WESFDVTPAVMRWTAQGHANHGFVVEVAHLEEKQGVSKRHVRISRSLHQDEHSWSQIRPL 263
           W SFDVT AV  W      N GF + + H      V   +  I     + E  ++ I   
Sbjct: 198 WLSFDVTDAVHEWLHHKDRNLGFKISL-HCPCCTFVPSNNYIIPNKSEELEARFAGIDGT 256

Query: 264 LVTFGHDGKGH-------------------PLHKREKRQAKHKQRKRL---------KSS 295
                 D K                     P ++ E +Q   ++++ L         + +
Sbjct: 257 STYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDN 316

Query: 296 CKRHPLYVDFS-DVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNS 354
           C   PLY+DF  D+GW  WI  P GY+A +C G CP+  +   + T H+ V +L N++N 
Sbjct: 317 CCLRPLYIDFKRDLGWK-WIHEPKGYNANFCAGACPYLWS---SDTQHSRVLSLYNTINP 372

Query: 355 KIPKA-CCVPTELSAISML-YLDENEKVVLKNYQDMVVEGCGC 395
           +   + CCV  +L  +++L Y+ +  K+  +   +M+V+ C C
Sbjct: 373 EASASPCCVSQDLEPLTILYYIGKTPKI--EQLSNMIVKSCKC 413


>gi|4885261 growth differentiation factor 9 precursor [Homo sapiens]
          Length = 454

 Score = 85.9 bits (211), Expect = 6e-17
 Identities = 35/105 (33%), Positives = 61/105 (58%), Gaps = 1/105 (0%)

Query: 293 KSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLV-NS 351
           ++ C+ H   + FS + W++WIVAP  Y+  YC G+CP  +     S  H +VQ ++   
Sbjct: 350 QNECELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYEK 409

Query: 352 VNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR 396
           ++S +P+  CVP + S +S+L ++ +  +  K Y+DM+   C CR
Sbjct: 410 LDSSVPRPSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTCR 454


>gi|5031613 growth differentiation factor 11 precursor [Homo
           sapiens]
          Length = 407

 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 91/364 (25%), Positives = 145/364 (39%), Gaps = 51/364 (14%)

Query: 50  LSEFELRLLSMFGLKQRPTPSRDAV------VPPY--MLDLYRRHSGQPGSPAPDHRLER 101
           L   + ++LS   LK+ P  SR+ V       PP   +LDL   H  Q  +  P+  LE 
Sbjct: 76  LESIKSQILSKLRLKEAPNISREVVKQLLPKAPPLQQILDL---HDFQGDALQPEDFLEE 132

Query: 102 AASRANTVRSFHHEESLEELPETSGKTTR-RFFFNLSSIPTEEFITSAELQVFREQMQDA 160
               A T       +  +   +T G      F F+   + T+  +  A+L V+   +   
Sbjct: 133 DEYHATTETVISMAQETDPAVQTDGSPLCCHFHFSPKVMFTK--VLKAQLWVYLRPVPRP 190

Query: 161 LGNNSSFHHRINIYEIIKPATANSKFPVTRLLDTRLV----NQNASRWESFDVTPAVMRW 216
               + +   + +  +    TA       R +  R +    +  +  W+S D    +  W
Sbjct: 191 A---TVYLQILRLKPLTGEGTAGGGGGGRRHIRIRSLKIELHSRSGHWQSIDFKQVLHSW 247

Query: 217 TAQGHANHGFVVEVAHLEEKQGVSKRHVRISRSLHQDEHSWSQIRPLLVTFGHDGKGHPL 276
             Q  +N G  +      +  G       +     +  H + ++R L  T          
Sbjct: 248 FRQPQSNWGIEINAF---DPSGTDLAVTSLGPGA-EGLHPFMELRVLENT---------- 293

Query: 277 HKREKRQA-----KHKQRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPF 331
            KR +R       +H    R    C R+PL VDF   GW DWI+AP  Y A YC G+C +
Sbjct: 294 -KRSRRNLGLDCDEHSSESR----CCRYPLTVDFEAFGW-DWIIAPKRYKANYCSGQCEY 347

Query: 332 PLADHLNSTNHAIVQTLVNSVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVE 391
                   T H + Q   N   S  P  CC PT++S I+MLY ++ ++++      MVV+
Sbjct: 348 MFMQKYPHT-HLVQQA--NPRGSAGP--CCTPTKMSPINMLYFNDKQQIIYGKIPGMVVD 402

Query: 392 GCGC 395
            CGC
Sbjct: 403 RCGC 406


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.133    0.408 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,469,114
Number of Sequences: 37866
Number of extensions: 785836
Number of successful extensions: 2368
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 41
Number of HSP's successfully gapped in prelim test: 13
Number of HSP's that attempted gapping in prelim test: 2248
Number of HSP's gapped (non-prelim): 71
length of query: 396
length of database: 18,247,518
effective HSP length: 104
effective length of query: 292
effective length of database: 14,309,454
effective search space: 4178360568
effective search space used: 4178360568
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.