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Search of human proteins with 4508047
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4508047 zyxin [Homo sapiens]
(572 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|58530845 zyxin [Homo sapiens] 1216 0.0
gi|4508047 zyxin [Homo sapiens] 1216 0.0
gi|5031887 LIM domain containing preferred translocation partner... 357 1e-98
gi|91208423 thyroid receptor-interacting protein 6 [Homo sapiens] 293 4e-79
gi|66932982 filamin-binding LIM protein-1 isoform a [Homo sapiens] 223 3e-58
gi|7657307 LIM domains containing 1 [Homo sapiens] 214 1e-55
gi|66932988 filamin-binding LIM protein-1 isoform c [Homo sapiens] 212 9e-55
gi|122937269 Wilms tumor 1 interacting protein [Homo sapiens] 202 7e-52
gi|14249622 ajuba isoform 1 [Homo sapiens] 200 3e-51
gi|66932986 filamin-binding LIM protein-1 isoform b [Homo sapiens] 143 4e-34
gi|37675280 ajuba isoform 2 [Homo sapiens] 141 2e-33
gi|109638745 transforming growth factor beta 1 induced transcrip... 122 9e-28
gi|21361591 transforming growth factor beta 1 induced transcript... 122 9e-28
gi|45592959 LIM domain binding 3 isoform 1 [Homo sapiens] 106 5e-23
gi|13518026 LIM and senescent cell antigen-like domains 1 [Homo ... 102 9e-22
gi|170932514 paxillin isoform 1 [Homo sapiens] 99 8e-21
gi|122056614 LIM domain binding 3 isoform 2 [Homo sapiens] 99 1e-20
gi|54112385 four and a half LIM domains 3 [Homo sapiens] 98 2e-20
gi|170932518 paxillin isoform 3 [Homo sapiens] 97 3e-20
gi|170932516 paxillin isoform 2 [Homo sapiens] 97 3e-20
gi|51173715 actin-binding LIM protein 1 isoform c [Homo sapiens] 96 1e-19
gi|51173713 actin-binding LIM protein 1 isoform b [Homo sapiens] 96 1e-19
gi|51173711 actin-binding LIM protein 1 isoform a [Homo sapiens] 96 1e-19
gi|238859658 LIM and senescent cell antigen-like domains 2 isofo... 95 2e-19
gi|238776788 LIM and senescent cell antigen-like domains 2 isofo... 95 2e-19
gi|238776786 LIM and senescent cell antigen-like domains 2 isofo... 95 2e-19
gi|40804748 LIM and senescent cell antigen-like domains 2 isofor... 95 2e-19
gi|47132519 Ras association and pleckstrin homology domains 1 is... 95 2e-19
gi|221316659 leupaxin isoform 1 [Homo sapiens] 94 3e-19
gi|4758670 leupaxin isoform 2 [Homo sapiens] 94 3e-19
>gi|58530845 zyxin [Homo sapiens]
Length = 572
Score = 1216 bits (3145), Expect = 0.0
Identities = 572/572 (100%), Positives = 572/572 (100%)
Query: 1 MAAPRPSPAISVSVSAPAFYAPQKKFGPVVAPKPKVNPFRPGDSEPPPAPGAQRAQMGRV 60
MAAPRPSPAISVSVSAPAFYAPQKKFGPVVAPKPKVNPFRPGDSEPPPAPGAQRAQMGRV
Sbjct: 1 MAAPRPSPAISVSVSAPAFYAPQKKFGPVVAPKPKVNPFRPGDSEPPPAPGAQRAQMGRV 60
Query: 61 GEIPPPPPEDFPLPPPPLAGDGDDAEGALGGAFPPPPPPIEESFPPAPLEEEIFPSPPPP 120
GEIPPPPPEDFPLPPPPLAGDGDDAEGALGGAFPPPPPPIEESFPPAPLEEEIFPSPPPP
Sbjct: 61 GEIPPPPPEDFPLPPPPLAGDGDDAEGALGGAFPPPPPPIEESFPPAPLEEEIFPSPPPP 120
Query: 121 PEEEGGPEAPIPPPPQPREKVSSIDLEIDSLSSLLDDMTKNDPFKARVSSGYVPPPVATP 180
PEEEGGPEAPIPPPPQPREKVSSIDLEIDSLSSLLDDMTKNDPFKARVSSGYVPPPVATP
Sbjct: 121 PEEEGGPEAPIPPPPQPREKVSSIDLEIDSLSSLLDDMTKNDPFKARVSSGYVPPPVATP 180
Query: 181 FSSKSSTKPAAGGTAPLPPWKSPSSSQPLPQVPAPAQSQTQFHVQPQPQPKPQVQLHVQS 240
FSSKSSTKPAAGGTAPLPPWKSPSSSQPLPQVPAPAQSQTQFHVQPQPQPKPQVQLHVQS
Sbjct: 181 FSSKSSTKPAAGGTAPLPPWKSPSSSQPLPQVPAPAQSQTQFHVQPQPQPKPQVQLHVQS 240
Query: 241 QTQPVSLANTQPRGPPASSPAPAPKFSPVTPKFTPVASKFSPGAPGGSGSQPNQKLGHPE 300
QTQPVSLANTQPRGPPASSPAPAPKFSPVTPKFTPVASKFSPGAPGGSGSQPNQKLGHPE
Sbjct: 241 QTQPVSLANTQPRGPPASSPAPAPKFSPVTPKFTPVASKFSPGAPGGSGSQPNQKLGHPE 300
Query: 301 ALSAGTGSPQPPSFTYAQQREKPRVQEKQHPVPPPAQNQNQVRSPGAPGPLTLKEVEELE 360
ALSAGTGSPQPPSFTYAQQREKPRVQEKQHPVPPPAQNQNQVRSPGAPGPLTLKEVEELE
Sbjct: 301 ALSAGTGSPQPPSFTYAQQREKPRVQEKQHPVPPPAQNQNQVRSPGAPGPLTLKEVEELE 360
Query: 361 QLTQQLMQDMEHPQRQNVAVNELCGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQ 420
QLTQQLMQDMEHPQRQNVAVNELCGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQ
Sbjct: 361 QLTQQLMQDMEHPQRQNVAVNELCGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQ 420
Query: 421 GQQFYSLEGAPYCEGCYTDTLEKCNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGT 480
GQQFYSLEGAPYCEGCYTDTLEKCNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGT
Sbjct: 421 GQQFYSLEGAPYCEGCYTDTLEKCNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGT 480
Query: 481 SFIVDQANRPHCVPDYHKQYAPRCSVCSEPIMPEPGRDETVRVVALDKNFHMKCYKCEDC 540
SFIVDQANRPHCVPDYHKQYAPRCSVCSEPIMPEPGRDETVRVVALDKNFHMKCYKCEDC
Sbjct: 481 SFIVDQANRPHCVPDYHKQYAPRCSVCSEPIMPEPGRDETVRVVALDKNFHMKCYKCEDC 540
Query: 541 GKPLSIEADDNGCFPLDGHVLCRKCHTARAQT 572
GKPLSIEADDNGCFPLDGHVLCRKCHTARAQT
Sbjct: 541 GKPLSIEADDNGCFPLDGHVLCRKCHTARAQT 572
>gi|4508047 zyxin [Homo sapiens]
Length = 572
Score = 1216 bits (3145), Expect = 0.0
Identities = 572/572 (100%), Positives = 572/572 (100%)
Query: 1 MAAPRPSPAISVSVSAPAFYAPQKKFGPVVAPKPKVNPFRPGDSEPPPAPGAQRAQMGRV 60
MAAPRPSPAISVSVSAPAFYAPQKKFGPVVAPKPKVNPFRPGDSEPPPAPGAQRAQMGRV
Sbjct: 1 MAAPRPSPAISVSVSAPAFYAPQKKFGPVVAPKPKVNPFRPGDSEPPPAPGAQRAQMGRV 60
Query: 61 GEIPPPPPEDFPLPPPPLAGDGDDAEGALGGAFPPPPPPIEESFPPAPLEEEIFPSPPPP 120
GEIPPPPPEDFPLPPPPLAGDGDDAEGALGGAFPPPPPPIEESFPPAPLEEEIFPSPPPP
Sbjct: 61 GEIPPPPPEDFPLPPPPLAGDGDDAEGALGGAFPPPPPPIEESFPPAPLEEEIFPSPPPP 120
Query: 121 PEEEGGPEAPIPPPPQPREKVSSIDLEIDSLSSLLDDMTKNDPFKARVSSGYVPPPVATP 180
PEEEGGPEAPIPPPPQPREKVSSIDLEIDSLSSLLDDMTKNDPFKARVSSGYVPPPVATP
Sbjct: 121 PEEEGGPEAPIPPPPQPREKVSSIDLEIDSLSSLLDDMTKNDPFKARVSSGYVPPPVATP 180
Query: 181 FSSKSSTKPAAGGTAPLPPWKSPSSSQPLPQVPAPAQSQTQFHVQPQPQPKPQVQLHVQS 240
FSSKSSTKPAAGGTAPLPPWKSPSSSQPLPQVPAPAQSQTQFHVQPQPQPKPQVQLHVQS
Sbjct: 181 FSSKSSTKPAAGGTAPLPPWKSPSSSQPLPQVPAPAQSQTQFHVQPQPQPKPQVQLHVQS 240
Query: 241 QTQPVSLANTQPRGPPASSPAPAPKFSPVTPKFTPVASKFSPGAPGGSGSQPNQKLGHPE 300
QTQPVSLANTQPRGPPASSPAPAPKFSPVTPKFTPVASKFSPGAPGGSGSQPNQKLGHPE
Sbjct: 241 QTQPVSLANTQPRGPPASSPAPAPKFSPVTPKFTPVASKFSPGAPGGSGSQPNQKLGHPE 300
Query: 301 ALSAGTGSPQPPSFTYAQQREKPRVQEKQHPVPPPAQNQNQVRSPGAPGPLTLKEVEELE 360
ALSAGTGSPQPPSFTYAQQREKPRVQEKQHPVPPPAQNQNQVRSPGAPGPLTLKEVEELE
Sbjct: 301 ALSAGTGSPQPPSFTYAQQREKPRVQEKQHPVPPPAQNQNQVRSPGAPGPLTLKEVEELE 360
Query: 361 QLTQQLMQDMEHPQRQNVAVNELCGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQ 420
QLTQQLMQDMEHPQRQNVAVNELCGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQ
Sbjct: 361 QLTQQLMQDMEHPQRQNVAVNELCGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQ 420
Query: 421 GQQFYSLEGAPYCEGCYTDTLEKCNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGT 480
GQQFYSLEGAPYCEGCYTDTLEKCNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGT
Sbjct: 421 GQQFYSLEGAPYCEGCYTDTLEKCNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGT 480
Query: 481 SFIVDQANRPHCVPDYHKQYAPRCSVCSEPIMPEPGRDETVRVVALDKNFHMKCYKCEDC 540
SFIVDQANRPHCVPDYHKQYAPRCSVCSEPIMPEPGRDETVRVVALDKNFHMKCYKCEDC
Sbjct: 481 SFIVDQANRPHCVPDYHKQYAPRCSVCSEPIMPEPGRDETVRVVALDKNFHMKCYKCEDC 540
Query: 541 GKPLSIEADDNGCFPLDGHVLCRKCHTARAQT 572
GKPLSIEADDNGCFPLDGHVLCRKCHTARAQT
Sbjct: 541 GKPLSIEADDNGCFPLDGHVLCRKCHTARAQT 572
>gi|5031887 LIM domain containing preferred translocation partner in
lipoma [Homo sapiens]
Length = 612
Score = 357 bits (917), Expect = 1e-98
Identities = 230/626 (36%), Positives = 310/626 (49%), Gaps = 119/626 (19%)
Query: 7 SPAISVSVSAPAFYAPQKKFGPVVAPKPKVNPFRPGDSEPPPAPGAQRAQMGRVGEIPPP 66
+P+ISVS P KKF PVVAPKPK NP++ Q G G+ PP
Sbjct: 31 NPSISVSTQQPP-----KKFAPVVAPKPKYNPYK---------------QPGGEGDFLPP 70
Query: 67 PPEDFPLPPPPLAGDGDDAEGALGGAFPPPPPPIEESFPPAPLEEEIFPSPPPPPEEEGG 126
PP PPL D A ++ G FPPPPP EE+F + +G
Sbjct: 71 PP-------PPL--DDSSALPSISGNFPPPPPLDEEAF-----------------KVQGN 104
Query: 127 PEAPIPPPPQPREKVSSIDLEIDSLSSLLDDMTKNDPFKAR----VSSGYVPPPVATPF- 181
P E+ SS+D EIDSL+S+L D+ + P+K R + PPV+TP
Sbjct: 105 PGG-----KTLEERRSSLDAEIDSLTSILADLECSSPYKPRPPQSSTGSTASPPVSTPVT 159
Query: 182 ---------------SSKSSTKPAAGGTAPLPPWKSPSSSQPLPQVPAPA-------QSQ 219
+ KS+ KP A P + +P PQ P PA S+
Sbjct: 160 GHKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQ-PVPASYTTASTSSR 218
Query: 220 TQFHVQ-PQPQPKPQVQLHVQS-----------QTQPVSLANTQP----RG--------P 255
F+VQ QP P S TQPV ++ P RG P
Sbjct: 219 PTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYIPP 278
Query: 256 PASSPAPAPKFSPVTPKFTPVASKFSPGAPGGSGSQPNQ-KLGHPEA-------LSAGTG 307
P P P ++P ++ PG G + S P + GHP G G
Sbjct: 279 PGLQPEPGYGYAPNQGRYYEGYYAAGPGYGGRNDSDPTYGQQGHPNTWKREPGYTPPGAG 338
Query: 308 SPQPPSFTYAQQREKPRVQEK-QHPVPPPAQ---NQNQVRSPGAPGPLTLKEVEELEQLT 363
+ PP +K + + P PP Q + P + P + + +ELE LT
Sbjct: 339 NQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAP-SFRPEDELEHLT 397
Query: 364 QQLMQDMEHPQRQNVAVNELCGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQ 423
++++ DME+P C RC + + A+ Q+FH+ CFTC C +L+GQ
Sbjct: 398 KKMLYDMENPPADEYFGR--CARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQP 455
Query: 424 FYSLEGAPYCEGCYTDTLEKCNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFI 483
FY++E YCE CY +TLE+CN C +PI +R+LRATGKAYHPHCFTCV+C R L+G F
Sbjct: 456 FYAVEKKAYCEPCYINTLEQCNVCSKPIMERILRATGKAYHPHCFTCVMCHRSLDGIPFT 515
Query: 484 VDQANRPHCVPDYHKQYAPRCSVCSEPIMPEPGRDETVRVVALDKNFHMKCYKCEDCGKP 543
VD HC+ D+HK++APRCSVC EPIMP PG++ETVR+VALD++FH+ CY+CEDCG
Sbjct: 516 VDAGGLIHCIEDFHKKFAPRCSVCKEPIMPAPGQEETVRIVALDRDFHVHCYRCEDCGGL 575
Query: 544 LSIEADDNGCFPLDGHVLCRKCHTAR 569
LS E D+ GC+PLDGH+LC+ C++AR
Sbjct: 576 LS-EGDNQGCYPLDGHILCKTCNSAR 600
>gi|91208423 thyroid receptor-interacting protein 6 [Homo sapiens]
Length = 476
Score = 293 bits (749), Expect = 4e-79
Identities = 199/541 (36%), Positives = 257/541 (47%), Gaps = 97/541 (17%)
Query: 46 PPPAPGAQRAQMGRVGEIPPPPPEDFPLPPPPLAGDGDDAEGALGGAFPPPPPPIEESFP 105
PP P RA GR P P PPP A G A P P +F
Sbjct: 8 PPKQPEPARAPQGRA------IPRGTPGPPP-----------AHGAALQPHP---RVNFC 47
Query: 106 PAPLEEEIFPSPPPPPEEEGGP----------EAPIPPPPQPREKVSSIDLEIDSLSSLL 155
P P E+ + +P P E+ GP P + + S+D EID LSS L
Sbjct: 48 PLP-SEQCYQAPGGP--EDRGPAWVGSHGVLQHTQGLPADRGGLRPGSLDAEIDLLSSTL 104
Query: 156 DDMTKNDPFKARVSS--GYVPPPVATPFSSKSSTKPAAGGTAPLPPWKSPSSSQPLPQVP 213
++ +R Y PPP P A T L P +P+S PLP P
Sbjct: 105 AELNGGRGHASRRPDRQAYEPPP------------PPAYRTGSLKP--NPAS--PLPASP 148
Query: 214 APAQSQTQFHVQPQPQ-PKPQVQLHVQSQTQPVSLANTQPRGPP-ASSPAPAPKFSPVTP 271
+ + P P VQ+ V QPV RG AS P P P F
Sbjct: 149 YGGPTPASYTTASTPAGPAFPVQVKV---AQPVRGCGPPRRGASQASGPLPGPHF----- 200
Query: 272 KFTPVASKFSPGAPGGSGSQPNQKLGHPEALSAGTGSPQPPSFTYAQQREK-PRVQEKQH 330
P+ + PG Y QRE P +E+
Sbjct: 201 ---PLPGRGEVWGPG-----------------------------YRSQREPGPGAKEEAA 228
Query: 331 PVPPPAQNQNQVRSPGAPGPLTLKEVEELEQLTQQLMQDMEHPQRQNVAVNELCGRCHQP 390
V PA + + G PL+ +EL++LT++L+ DM HP CG C +
Sbjct: 229 GVSGPA-GRGRGGEHGPQVPLSQPPEDELDRLTKKLVHDMNHPPSGEYFGQ--CGGCGED 285
Query: 391 LARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDTLEKCNTCGEP 450
+ V AL ++FH+ CF C C QL+GQ FY++E YCEGCY TLEKC TC +P
Sbjct: 286 VVGDGAGVVALDRVFHVGCFVCSTCRAQLRGQHFYAVERRAYCEGCYVATLEKCATCSQP 345
Query: 451 ITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHKQYAPRCSVCSEP 510
I DR+LRA GKAYHP CFTCVVC R L+G F VD ++ HC+ D+H+++APRCSVC
Sbjct: 346 ILDRILRAMGKAYHPGCFTCVVCHRGLDGIPFTVDATSQIHCIEDFHRKFAPRCSVCGGA 405
Query: 511 IMPEPGRDETVRVVALDKNFHMKCYKCEDCGKPLSIEADDNGCFPLDGHVLCRKCHTARA 570
IMPEPG++ETVR+VALD++FH+ CYKCE+CG LS E + GC+PLDGH+LC+ C R
Sbjct: 406 IMPEPGQEETVRIVALDRSFHIGCYKCEECGLLLSSEGECQGCYPLDGHILCKACSAWRI 465
Query: 571 Q 571
Q
Sbjct: 466 Q 466
>gi|66932982 filamin-binding LIM protein-1 isoform a [Homo sapiens]
Length = 373
Score = 223 bits (569), Expect = 3e-58
Identities = 105/271 (38%), Positives = 150/271 (55%), Gaps = 19/271 (7%)
Query: 309 PQPPSFTYAQQREKPRVQ--------EKQHPVPPPAQNQNQVRSPGA-PGPLTLKEVEEL 359
P PP + E P E+ H PPP Q P PGPL E
Sbjct: 108 PPPPPVLLPSEEEAPAPMGASLIADLEQLHLSPPPPPPQAPAEGPSVQPGPLRPME---- 163
Query: 360 EQLTQQLMQDMEHPQRQNVAVNELCGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQL 419
E+L + +E A ++C CH+ ++ + AV A+ + +H CFTC C +QL
Sbjct: 164 EELPPPPAEPVEKG-----ASTDICAFCHKTVSPRELAVEAMKRQYHAQCFTCRTCRRQL 218
Query: 420 QGQQFYSLEGAPYCEGCYTDTLEKCNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEG 479
GQ FY +G P CE CY DTLE+C CGE + D ++RA G+A+HP CFTCV CAR +
Sbjct: 219 AGQSFYQKDGRPLCEPCYQDTLERCGKCGEVVRDHIIRALGQAFHPSCFTCVTCARCIGD 278
Query: 480 TSFIVDQANRPHCVPDYHKQYAPRCSVCSEPIMPEPGRDETVRVVALDKNFHMKCYKCED 539
SF + N +C+ D+++++AP CS+C PI+P G+D ++ + +NFH CY+CED
Sbjct: 279 ESFALGSQNEVYCLDDFYRKFAPVCSICENPIIPRDGKD-AFKIECMGRNFHENCYRCED 337
Query: 540 CGKPLSIEADDNGCFPLDGHVLCRKCHTARA 570
C LS+E D GC+PL+ H+ C+ CH R+
Sbjct: 338 CRILLSVEPTDQGCYPLNNHLFCKPCHVKRS 368
Score = 58.5 bits (140), Expect = 2e-08
Identities = 54/172 (31%), Positives = 71/172 (41%), Gaps = 32/172 (18%)
Query: 1 MAAPRPSPAISVSVSAPAFYAPQKKFGPVVAPKPKVNPFRPGDSEPPPAPGAQRAQMGRV 60
+A PR A++ V A + + P AP P P P P RA
Sbjct: 17 LAPPRRDVAVAEEVRQAVCEARRGR--PWEAPAPMKTPEAGLAGRPSPWTTPGRA----A 70
Query: 61 GEIPPPPPEDFP--LPPPPLAGDGDDAEGALGGAFPPPPPP----IEESFPPAPLE---- 110
+P P + F PPPP DG+D L PPPPPP E PAP+
Sbjct: 71 ATVPAAPMQLFNGGCPPPPPVLDGEDVLPDLDLLPPPPPPPPVLLPSEEEAPAPMGASLI 130
Query: 111 ---EEIFPSPPPPPEE--------EGGPEAPI-----PPPPQPREKVSSIDL 146
E++ SPPPPP + + GP P+ PPP +P EK +S D+
Sbjct: 131 ADLEQLHLSPPPPPPQAPAEGPSVQPGPLRPMEEELPPPPAEPVEKGASTDI 182
>gi|7657307 LIM domains containing 1 [Homo sapiens]
Length = 676
Score = 214 bits (546), Expect = 1e-55
Identities = 137/416 (32%), Positives = 199/416 (47%), Gaps = 51/416 (12%)
Query: 196 PLPPWKSPSSSQPLPQVPAPAQSQTQFHVQPQPQPKPQVQLHVQSQTQPVSLANTQPRGP 255
P W + SS + P +P+P V P VQ S + P++L+ + G
Sbjct: 259 PTGLWSTASSQRVSPGLPSPNLENGAPAVGP-------VQPRTPSVSAPLALSCPRQGGL 311
Query: 256 PASSPAPAPKFSPVT--PKFTPVA-------SKFSPGAPGGS-----GSQPNQKLG---H 298
P S+ + S V P P S S AP S GSQ G
Sbjct: 312 PRSNSGLGGEVSGVMSKPNVDPQPWFQDGPKSYLSSSAPSSSPAGLDGSQQGAVPGLGPK 371
Query: 299 PEALSAGTGSP-QPPSFTYAQQREKPRVQEKQHPV--------------PPPAQNQNQVR 343
P GTG P S + P + K+ P+ P +
Sbjct: 372 PGCTDLGTGPKLSPTSLVHPVMSTLPELSCKEGPLGWSSDGSLGSVLLDSPSSPRVRLPC 431
Query: 344 SPGAPGPLTLKEVEEL--EQLTQQLMQDME-HPQRQNVAVNELCGRCHQPLARAQPAVRA 400
P PGP EL E LTQ+L ++M+ HP+ C +C + + A A +A
Sbjct: 432 QPLVPGPELRPSAAELKLEALTQRLEREMDAHPKADYFGA---CVKCSKGVFGAGQACQA 488
Query: 401 LGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCE-----GCYTDTLEKCNTCGEPITDRM 455
+G L+H CFTC C+++L+G+ FY + G +CE + + ++C CG I D +
Sbjct: 489 MGNLYHDTCFTCAACSRKLRGKAFYFVNGKVFCEEDFLYSGFQQSADRCFLCGHLIMDMI 548
Query: 456 LRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHKQYAPRCSVCSEPIMPEP 515
L+A GK+YHP CF CV+C L+G F VD N+ +CV DYHK AP+C+ C PI+P
Sbjct: 549 LQALGKSYHPGCFRCVICNECLDGVPFTVDSENKIYCVRDYHKVLAPKCAACGLPILPPE 608
Query: 516 GRDETVRVVALDKNFHMKCYKCEDCGKPLSIEADDNGCFPLDGHVLCRKCHTARAQ 571
G DET+RVV++D+++H++CY CEDCG L+ E D + C+PL+ H+ C CH R +
Sbjct: 609 GSDETIRVVSMDRDYHVECYHCEDCGLELNDE-DGHRCYPLEDHLFCHSCHVKRLE 663
Score = 37.0 bits (84), Expect = 0.049
Identities = 23/93 (24%), Positives = 37/93 (39%), Gaps = 21/93 (22%)
Query: 384 CGRCHQPLARAQPA-----VRALGQLFHIACFTCHQCAQQLQ---GQQFYSLEGAPYCEG 435
C C P+ + + V ++ + +H+ C+ C C +L G + Y LE +C
Sbjct: 597 CAACGLPILPPEGSDETIRVVSMDRDYHVECYHCEDCGLELNDEDGHRCYPLEDHLFCHS 656
Query: 436 CYTDTLEKCNTCGEPITDRMLRATGKAYHPHCF 468
C+ LEK R + A H H F
Sbjct: 657 CHVKRLEK-------------RPSSTALHQHHF 676
Score = 32.7 bits (73), Expect = 0.92
Identities = 64/277 (23%), Positives = 87/277 (31%), Gaps = 70/277 (25%)
Query: 109 LEEEIFPSPPPPPEEEGGPEAPIPPPPQPREKVSSIDLEIDSLSSLLDDMTKNDPFKARV 168
L+EE P P GG P Q R +V L +D
Sbjct: 65 LQEETLPRGSRGPVNGGGRLGP-----QARWEVVGSKLTVD------------------- 100
Query: 169 SSGYVPPPVATPFSSKSSTKPAAGGTAPLPPWKSPS---------SSQPLPQVPAPAQSQ 219
G PP+A + + A G P PP + S SQ + A S+
Sbjct: 101 --GAAKPPLAASTGAPGAVTTLAAGQPPYPPQEQRSRPYLHGTRHGSQDCGSRESLATSE 158
Query: 220 TQFHVQPQPQPKPQVQLHVQSQTQPVSLANTQPRGPPASSPA----------PAPKFSPV 269
QP P P H +SLA+ + P SP+ +P P
Sbjct: 159 MSAFHQPGPCEDPSCLTH-GDYYDNLSLASPKWGDKPGVSPSIGLSVGSGWPSSPGSDPP 217
Query: 270 TPK-----------FTPVASKFSPGAPGGSGSQPNQKLGHPEALSAGTGSPQPPSF--TY 316
PK + +S+ S G+ GG N +G G S +P T
Sbjct: 218 LPKPCGDHPLNHRQLSLSSSRSSEGSLGGQ----NSGIG-------GRSSEKPTGLWSTA 266
Query: 317 AQQREKPRVQEKQHPVPPPAQNQNQVRSPGAPGPLTL 353
+ QR P + PA Q R+P PL L
Sbjct: 267 SSQRVSPGLPSPNLENGAPAVGPVQPRTPSVSAPLAL 303
>gi|66932988 filamin-binding LIM protein-1 isoform c [Homo sapiens]
Length = 276
Score = 212 bits (539), Expect = 9e-55
Identities = 84/189 (44%), Positives = 124/189 (65%), Gaps = 1/189 (0%)
Query: 382 ELCGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDTL 441
++C CH+ ++ + AV A+ + +H CFTC C +QL GQ FY +G P CE CY DTL
Sbjct: 84 DICAFCHKTVSPRELAVEAMKRQYHAQCFTCRTCRRQLAGQSFYQKDGRPLCEPCYQDTL 143
Query: 442 EKCNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHKQYA 501
E+C CGE + D ++RA G+A+HP CFTCV CAR + SF + N +C+ D+++++A
Sbjct: 144 ERCGKCGEVVRDHIIRALGQAFHPSCFTCVTCARCIGDESFALGSQNEVYCLDDFYRKFA 203
Query: 502 PRCSVCSEPIMPEPGRDETVRVVALDKNFHMKCYKCEDCGKPLSIEADDNGCFPLDGHVL 561
P CS+C PI+P G+D ++ + +NFH CY+CEDC LS+E D GC+PL+ H+
Sbjct: 204 PVCSICENPIIPRDGKD-AFKIECMGRNFHENCYRCEDCRILLSVEPTDQGCYPLNNHLF 262
Query: 562 CRKCHTARA 570
C+ CH R+
Sbjct: 263 CKPCHVKRS 271
>gi|122937269 Wilms tumor 1 interacting protein [Homo sapiens]
Length = 430
Score = 202 bits (514), Expect = 7e-52
Identities = 119/338 (35%), Positives = 176/338 (52%), Gaps = 32/338 (9%)
Query: 240 SQTQPVSLANTQPRGPPASSPAPAPKFSPVTPKFTPVASKFSP-GAPGGSGSQPNQKLGH 298
+++ +SL Q G P S + P+ P P S S G+ G +G+ +
Sbjct: 105 ARSSGISLGYDQRHGSPRSGRSD-PRPGPGPPSVGSARSSVSSLGSRGSAGAYAD--FLP 161
Query: 299 PEALSAGTGSPQPPSFTYAQQREKPRVQEKQHPVPPPAQNQNQVRSPGAPGPLTLKEVEE 358
P A A SP+P P P PA PG G + E
Sbjct: 162 PGACPAPARSPEPAG---------------PAPFPLPALPL----PPGREGGPSAAE-RR 201
Query: 359 LEQLTQQLMQDMEHPQRQNVAVNELCGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQ 418
LE LT++L + +E ++ +C +C + AQ A +A+G L+H CFTC C ++
Sbjct: 202 LEALTRELERALEARTARDYF--GICIKCGLGIYGAQQACQAMGSLYHTDCFTCDSCGRR 259
Query: 419 LQGQQFYSLEGAPYCE-----GCYTDTLEKCNTCGEPITDRMLRATGKAYHPHCFTCVVC 473
L+G+ FY++ YC+ + T +KC+ CG I + +L+A GK+YHP CF C VC
Sbjct: 260 LRGKAFYNVGEKVYCQEDFLYSGFQQTADKCSVCGHLIMEMILQALGKSYHPGCFRCSVC 319
Query: 474 ARPLEGTSFIVDQANRPHCVPDYHKQYAPRCSVCSEPIMPEPGRDETVRVVALDKNFHMK 533
L+G F VD N +CV DYH +AP+C+ C+ PI+P G + T+RVV++D+++H+
Sbjct: 320 NECLDGVPFTVDVENNIYCVRDYHTVFAPKCASCARPILPAQGCETTIRVVSMDRDYHVA 379
Query: 534 CYKCEDCGKPLSIEADDNGCFPLDGHVLCRKCHTARAQ 571
CY CEDCG LS E + C+PL GH+LCR+CH R Q
Sbjct: 380 CYHCEDCGLQLSGE-EGRRCYPLAGHLLCRRCHLRRLQ 416
Score = 32.0 bits (71), Expect = 1.6
Identities = 23/68 (33%), Positives = 26/68 (38%), Gaps = 10/68 (14%)
Query: 72 PLPPPPLAGDGDDAEGALGGA--------FPPPPPPIEESFPPAPLEEEIFPSP--PPPP 121
P P PP G + +LG F PP + P P FP P P PP
Sbjct: 130 PGPGPPSVGSARSSVSSLGSRGSAGAYADFLPPGACPAPARSPEPAGPAPFPLPALPLPP 189
Query: 122 EEEGGPEA 129
EGGP A
Sbjct: 190 GREGGPSA 197
>gi|14249622 ajuba isoform 1 [Homo sapiens]
Length = 538
Score = 200 bits (508), Expect = 3e-51
Identities = 167/576 (28%), Positives = 236/576 (40%), Gaps = 112/576 (19%)
Query: 40 RPGDSEPPPAPGAQRAQMGRVGEIPPPP----------PEDFPLPPPPLAGDGDDAEGAL 89
R G+S + G GR+ + P P D PL P G D AE
Sbjct: 18 RKGESSRSGSDGTPGPGKGRLSGLGGPRKSGPRGATGGPGDEPLEPAREQGSLD-AERNQ 76
Query: 90 GGAFPPPPPPIEESFPPAPLEEEIFPSPPP-PPEEEGGPEAPIPPPPQPREKVSSIDLEI 148
G+F P E SFP P P P PP+ P AP PR +S
Sbjct: 77 RGSFEAPR--YEGSFPAGPPPTRALPLPQSLPPDFRLEPTAPAL---SPRSSFAS----- 126
Query: 149 DSLSSLLDDMTKNDPFKARVSSGYVPPPVATPFSSKSSTKPAAGGTAPLPPWKSPSSSQP 208
SS D + P + + G AGG P + +S
Sbjct: 127 ---SSASDASKPSSPRGSLLLDG-----------------AGAGGAGGSRPCSNRTSGIS 166
Query: 209 LPQVPAPAQSQTQFHVQPQPQPKPQVQLHVQSQTQPVSLANTQPRGPPASSPAPAPKFSP 268
+ Q H P P P P SP P
Sbjct: 167 M--------GYDQRHGSPLP-------------AGPCLFGPPLAGAPAGYSPGGVPS--- 202
Query: 269 VTPKFTPVASKFSPGAPGGSGSQPNQK-----LGHPEALS-AGTGSPQPPSFTYAQQREK 322
P+ + P G G Q ++ LG P AL+ AG G+ P E+
Sbjct: 203 AYPELHAALDRLYAQRPAGFGCQESRHSYPPALGSPGALAGAGVGAAGP--------LER 254
Query: 323 PRVQEKQHPVPP------PAQNQNQV------------RSPGAPGPLTLKEVEELEQLTQ 364
Q +H V A+ Q+++ R GA G + E LE+
Sbjct: 255 RGAQPGRHSVTGYGDCAVGARYQDELTALLRLTVGTGGREAGARGEPSGIEPSGLEEPPG 314
Query: 365 QLMQDMEHPQRQNVAVNE----LCGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQ 420
+ + + + E C +C++ + A +AL L+H CF C C + L+
Sbjct: 315 PFVPEAARARMREPEAREDYFGTCIKCNKGIYGQSNACQALDSLYHTQCFVCCSCGRTLR 374
Query: 421 GQQFYSLEGAPYCEGCYT-----DTLEKCNTCGEPITDRMLRATGKAYHPHCFTCVVCAR 475
+ FYS+ G+ YCE Y + EKC CG I +++L+A GK+YHP CF C+VC +
Sbjct: 375 CKAFYSVNGSVYCEEDYLFSGFQEAAEKCCVCGHLILEKILQAMGKSYHPGCFRCIVCNK 434
Query: 476 PLEGTSFIVDQANRPHCVPDYHKQYAPRCSVCSEPIMPEPGRDETVRVVALDKNFHMKCY 535
L+G F VD +N+ +CV DYHK YAP+C+ C +PI+P G ++ VRV+++D+++H +CY
Sbjct: 435 CLDGIPFTVDFSNQVYCVTDYHKNYAPKCAACGQPILPSEGCEDIVRVISMDRDYHFECY 494
Query: 536 KCEDCGKPLSIEADDNG--CFPLDGHVLCRKCHTAR 569
CEDC LS D+ G CFPLDGH+LC CH R
Sbjct: 495 HCEDCRMQLS---DEEGCCCFPLDGHLLCHGCHMQR 527
Score = 35.4 bits (80), Expect = 0.14
Identities = 17/66 (25%), Positives = 30/66 (45%), Gaps = 8/66 (12%)
Query: 384 CGRCHQPLARAQPA-----VRALGQLFHIACFTCHQCAQQLQGQQ---FYSLEGAPYCEG 435
C C QP+ ++ V ++ + +H C+ C C QL ++ + L+G C G
Sbjct: 463 CAACGQPILPSEGCEDIVRVISMDRDYHFECYHCEDCRMQLSDEEGCCCFPLDGHLLCHG 522
Query: 436 CYTDTL 441
C+ L
Sbjct: 523 CHMQRL 528
>gi|66932986 filamin-binding LIM protein-1 isoform b [Homo sapiens]
Length = 374
Score = 143 bits (361), Expect = 4e-34
Identities = 74/206 (35%), Positives = 104/206 (50%), Gaps = 18/206 (8%)
Query: 309 PQPPSFTYAQQREKPRVQ--------EKQHPVPPPAQNQNQVRSPGA-PGPLTLKEVEEL 359
P PP + E P E+ H PPP Q P PGPL E
Sbjct: 108 PPPPPVLLPSEEEAPAPMGASLIADLEQLHLSPPPPPPQAPAEGPSVQPGPLRPME---- 163
Query: 360 EQLTQQLMQDMEHPQRQNVAVNELCGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQL 419
E+L + +E A ++C CH+ ++ + AV A+ + +H CFTC C +QL
Sbjct: 164 EELPPPPAEPVEKG-----ASTDICAFCHKTVSPRELAVEAMKRQYHAQCFTCRTCRRQL 218
Query: 420 QGQQFYSLEGAPYCEGCYTDTLEKCNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEG 479
GQ FY +G P CE CY DTLE+C CGE + D ++RA G+A+HP CFTCV CAR +
Sbjct: 219 AGQSFYQKDGRPLCEPCYQDTLERCGKCGEVVRDHIIRALGQAFHPSCFTCVTCARCIGD 278
Query: 480 TSFIVDQANRPHCVPDYHKQYAPRCS 505
SF + N +C+ D+++ C+
Sbjct: 279 ESFALGSQNEVYCLDDFYRYEKGLCT 304
Score = 60.8 bits (146), Expect = 3e-09
Identities = 41/120 (34%), Positives = 55/120 (45%), Gaps = 14/120 (11%)
Query: 431 PYCEGCYTDTLEKCNTCGEPITDRML--RATGKAYHPHCFTCVVCARPLEGTSFIVDQAN 488
P +G TD C C + ++ R L A + YH CFTC C R L G SF +
Sbjct: 173 PVEKGASTDI---CAFCHKTVSPRELAVEAMKRQYHAQCFTCRTCRRQLAGQSFY-QKDG 228
Query: 489 RPHCVPDYHKQYAPRCSVCSEPIMPEPGRDETVRVVALDKNFHMKCYKCEDCGKPLSIEA 548
RP C P Y + RC C E + RD +R AL + FH C+ C C + + E+
Sbjct: 229 RPLCEPCY-QDTLERCGKCGEVV-----RDHIIR--ALGQAFHPSCFTCVTCARCIGDES 280
Score = 58.5 bits (140), Expect = 2e-08
Identities = 54/172 (31%), Positives = 71/172 (41%), Gaps = 32/172 (18%)
Query: 1 MAAPRPSPAISVSVSAPAFYAPQKKFGPVVAPKPKVNPFRPGDSEPPPAPGAQRAQMGRV 60
+A PR A++ V A + + P AP P P P P RA
Sbjct: 17 LAPPRRDVAVAEEVRQAVCEARRGR--PWEAPAPMKTPEAGLAGRPSPWTTPGRA----A 70
Query: 61 GEIPPPPPEDFP--LPPPPLAGDGDDAEGALGGAFPPPPPP----IEESFPPAPLE---- 110
+P P + F PPPP DG+D L PPPPPP E PAP+
Sbjct: 71 ATVPAAPMQLFNGGCPPPPPVLDGEDVLPDLDLLPPPPPPPPVLLPSEEEAPAPMGASLI 130
Query: 111 ---EEIFPSPPPPPEE--------EGGPEAPI-----PPPPQPREKVSSIDL 146
E++ SPPPPP + + GP P+ PPP +P EK +S D+
Sbjct: 131 ADLEQLHLSPPPPPPQAPAEGPSVQPGPLRPMEEELPPPPAEPVEKGASTDI 182
Score = 33.9 bits (76), Expect = 0.41
Identities = 15/63 (23%), Positives = 28/63 (44%), Gaps = 9/63 (14%)
Query: 504 CSVCSEPIMPEPGRDETVRVVALDKNFHMKCYKCEDCGKPLSIEADDNGCFPLDGHVLCR 563
C+ C + + P + V A+ + +H +C+ C C + L+ + DG LC
Sbjct: 183 CAFCHKTVSPRE-----LAVEAMKRQYHAQCFTCRTCRRQLA----GQSFYQKDGRPLCE 233
Query: 564 KCH 566
C+
Sbjct: 234 PCY 236
>gi|37675280 ajuba isoform 2 [Homo sapiens]
Length = 121
Score = 141 bits (355), Expect = 2e-33
Identities = 58/112 (51%), Positives = 80/112 (71%), Gaps = 5/112 (4%)
Query: 460 GKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHKQYAPRCSVCSEPIMPEPGRDE 519
GK+YHP CF C+VC + L+G F VD +N+ +CV DYHK YAP+C+ C +PI+P G ++
Sbjct: 2 GKSYHPGCFRCIVCNKCLDGIPFTVDFSNQVYCVTDYHKNYAPKCAACGQPILPSEGCED 61
Query: 520 TVRVVALDKNFHMKCYKCEDCGKPLSIEADDNG--CFPLDGHVLCRKCHTAR 569
VRV+++D+++H +CY CEDC LS D+ G CFPLDGH+LC CH R
Sbjct: 62 IVRVISMDRDYHFECYHCEDCRMQLS---DEEGCCCFPLDGHLLCHGCHMQR 110
Score = 35.4 bits (80), Expect = 0.14
Identities = 17/66 (25%), Positives = 30/66 (45%), Gaps = 8/66 (12%)
Query: 384 CGRCHQPLARAQPA-----VRALGQLFHIACFTCHQCAQQLQGQQ---FYSLEGAPYCEG 435
C C QP+ ++ V ++ + +H C+ C C QL ++ + L+G C G
Sbjct: 46 CAACGQPILPSEGCEDIVRVISMDRDYHFECYHCEDCRMQLSDEEGCCCFPLDGHLLCHG 105
Query: 436 CYTDTL 441
C+ L
Sbjct: 106 CHMQRL 111
>gi|109638745 transforming growth factor beta 1 induced transcript 1
isoform 1 [Homo sapiens]
Length = 461
Score = 122 bits (306), Expect = 9e-28
Identities = 84/302 (27%), Positives = 126/302 (41%), Gaps = 27/302 (8%)
Query: 277 ASKFSPGAPGGSGSQPNQKLGHPEALSAGTGSPQPPSFTYAQQREKPRVQE---KQH--- 330
+SK + G S+ ++ P + S G S T R + + + H
Sbjct: 117 SSKVASGEQKEDQSEDKKRPSLPSSPSPGLPKASATSATLELDRLMASLSDFRVQNHLPA 176
Query: 331 --PVPPPAQNQNQVRSPGAPGPLTLKEVEELEQLTQQLMQDMEHPQRQNVAVNELCGRCH 388
P PP + SP P P ++ + L Q + P + LCG C+
Sbjct: 177 SGPTQPPVVSSTNEGSPSPPEPTGKGSLDTMLGLLQSDLSRRGVPTQ----AKGLCGSCN 232
Query: 389 QPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDTLE-KCNTC 447
+P+A V ALG+ +H F C C+ L G F+ +GAP+C CY + +C C
Sbjct: 233 KPIAGQ--VVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSPRCGFC 290
Query: 448 GEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHKQYAPRCSVC 507
+PI +M+ A G +HP F CV C P G ++ RP+C D+ + +APRC C
Sbjct: 291 NQPIRHKMVTALGTHWHPEHFCCVSCGEPF-GDEGFHEREGRPYCRRDFLQLFAPRCQGC 349
Query: 508 SEPIMPEPGRDETVRVVALDKNFHMKCYKCEDCGKPLSIEADDNGCFPLDGHVLCRKCHT 567
PI+ + AL +H C+ C +C P S F +G LC
Sbjct: 350 QGPILDN-------YISALSALWHPDCFVCRECFAPFS----GGSFFEHEGRPLCENHFH 398
Query: 568 AR 569
AR
Sbjct: 399 AR 400
Score = 83.6 bits (205), Expect = 5e-16
Identities = 43/118 (36%), Positives = 59/118 (50%), Gaps = 4/118 (3%)
Query: 384 CGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDTLEK 443
C C P+ + AL L+H CF C +C G F+ EG P CE +
Sbjct: 346 CQGCQGPIL--DNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGS 403
Query: 444 -CNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHKQY 500
C TCG P+T R + A G+ +HP FTC C RPL SF ++A +P+C P + K +
Sbjct: 404 LCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLTKGSF-QERAGKPYCQPCFLKLF 460
Score = 32.3 bits (72), Expect = 1.2
Identities = 23/77 (29%), Positives = 33/77 (42%), Gaps = 4/77 (5%)
Query: 122 EEEGGPEAPIPPPPQ-PREKVSSIDLEIDSLSSLLDDMTKNDPFKARVSSGYVPPPVATP 180
E++ P P P P P+ +S LE+D L + L D + A SG PPV +
Sbjct: 131 EDKKRPSLPSSPSPGLPKASATSATLELDRLMASLSDFRVQNHLPA---SGPTQPPVVSS 187
Query: 181 FSSKSSTKPAAGGTAPL 197
+ S + P G L
Sbjct: 188 TNEGSPSPPEPTGKGSL 204
>gi|21361591 transforming growth factor beta 1 induced transcript 1
isoform 2 [Homo sapiens]
Length = 444
Score = 122 bits (306), Expect = 9e-28
Identities = 84/302 (27%), Positives = 126/302 (41%), Gaps = 27/302 (8%)
Query: 277 ASKFSPGAPGGSGSQPNQKLGHPEALSAGTGSPQPPSFTYAQQREKPRVQE---KQH--- 330
+SK + G S+ ++ P + S G S T R + + + H
Sbjct: 100 SSKVASGEQKEDQSEDKKRPSLPSSPSPGLPKASATSATLELDRLMASLSDFRVQNHLPA 159
Query: 331 --PVPPPAQNQNQVRSPGAPGPLTLKEVEELEQLTQQLMQDMEHPQRQNVAVNELCGRCH 388
P PP + SP P P ++ + L Q + P + LCG C+
Sbjct: 160 SGPTQPPVVSSTNEGSPSPPEPTGKGSLDTMLGLLQSDLSRRGVPTQ----AKGLCGSCN 215
Query: 389 QPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDTLE-KCNTC 447
+P+A V ALG+ +H F C C+ L G F+ +GAP+C CY + +C C
Sbjct: 216 KPIAGQ--VVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSPRCGFC 273
Query: 448 GEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHKQYAPRCSVC 507
+PI +M+ A G +HP F CV C P G ++ RP+C D+ + +APRC C
Sbjct: 274 NQPIRHKMVTALGTHWHPEHFCCVSCGEPF-GDEGFHEREGRPYCRRDFLQLFAPRCQGC 332
Query: 508 SEPIMPEPGRDETVRVVALDKNFHMKCYKCEDCGKPLSIEADDNGCFPLDGHVLCRKCHT 567
PI+ + AL +H C+ C +C P S F +G LC
Sbjct: 333 QGPILDN-------YISALSALWHPDCFVCRECFAPFS----GGSFFEHEGRPLCENHFH 381
Query: 568 AR 569
AR
Sbjct: 382 AR 383
Score = 83.6 bits (205), Expect = 5e-16
Identities = 43/118 (36%), Positives = 59/118 (50%), Gaps = 4/118 (3%)
Query: 384 CGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDTLEK 443
C C P+ + AL L+H CF C +C G F+ EG P CE +
Sbjct: 329 CQGCQGPIL--DNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGS 386
Query: 444 -CNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHKQY 500
C TCG P+T R + A G+ +HP FTC C RPL SF ++A +P+C P + K +
Sbjct: 387 LCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLTKGSF-QERAGKPYCQPCFLKLF 443
Score = 32.3 bits (72), Expect = 1.2
Identities = 23/77 (29%), Positives = 33/77 (42%), Gaps = 4/77 (5%)
Query: 122 EEEGGPEAPIPPPPQ-PREKVSSIDLEIDSLSSLLDDMTKNDPFKARVSSGYVPPPVATP 180
E++ P P P P P+ +S LE+D L + L D + A SG PPV +
Sbjct: 114 EDKKRPSLPSSPSPGLPKASATSATLELDRLMASLSDFRVQNHLPA---SGPTQPPVVSS 170
Query: 181 FSSKSSTKPAAGGTAPL 197
+ S + P G L
Sbjct: 171 TNEGSPSPPEPTGKGSL 187
>gi|45592959 LIM domain binding 3 isoform 1 [Homo sapiens]
Length = 727
Score = 106 bits (265), Expect = 5e-23
Identities = 112/424 (26%), Positives = 162/424 (38%), Gaps = 66/424 (15%)
Query: 166 ARVSSGYVPPPVATP-----FSSKSSTKPAAG-GTAPLPPWKSPSSSQPLPQVPAPAQSQ 219
A S PP+AT +S S+T PA+ +P P S S + PA S
Sbjct: 325 AAASPSAASPPLATAAAHTAIASASTTAPASSPADSPRPQASSYSPAVAASSAPATHTSY 384
Query: 220 TQFHVQPQPQPK--------PQVQLHVQSQT-QPVSLANTQPRG-----PPASSPAPAPK 265
++ P P+P+ P V V + T P AN P PA +P+PAP
Sbjct: 385 SEGPAAPAPKPRVVTTASIRPSVYQPVPASTYSPSPGANYSPTPYTPSPAPAYTPSPAPA 444
Query: 266 FSPV-TPKFTPVASKFSPGAPGGSGSQPNQKLGHPEALSAGTGSP--QPPSFT------- 315
++P P +TP SP PN A S G P +PP T
Sbjct: 445 YTPSPVPTYTP-----SPAPAYTPSPAPNYNPAPSVAYSGGPAEPASRPPWVTDDSFSQK 499
Query: 316 YAQQREKPRVQEKQHPVPPPAQNQNQVRSPGAPGPLTLKEVEELEQLTQQLMQDMEHPQR 375
+A + + ++ P PA +P P +V L + T Q + R
Sbjct: 500 FAPGKSTTSISKQTLPRGGPAY------TPAGP------QVPPLARGTVQRAERFPASSR 547
Query: 376 QNVAVNELCGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEG 435
LCG C+ + P + A+G+ +H FTC C L F + YCE
Sbjct: 548 -----TPLCGHCNNVIRG--PFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCER 600
Query: 436 CYTDTLEK-CNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVP 494
CY C C I ++ A + +H CF C C +P G S + P+C
Sbjct: 601 CYEQFFAPLCAKCNTKIMGEVMHALRQTWHTTCFVCAACKKPF-GNSLFHMEDGEPYCEK 659
Query: 495 DYHKQYAPRCSVCSEPIMPEPGRDETVRVVALDKNFHMKCYKCEDC-----GKPLSIEAD 549
DY ++ +C C P+ E G D+ + AL +H C+ C C G+P + D
Sbjct: 660 DYINLFSTKCHGCDFPV--EAG-DKFIE--ALGHTWHDTCFICAVCHVNLEGQPFYSKKD 714
Query: 550 DNGC 553
C
Sbjct: 715 RPLC 718
Score = 94.7 bits (234), Expect = 2e-19
Identities = 105/419 (25%), Positives = 146/419 (34%), Gaps = 49/419 (11%)
Query: 118 PPPPEEEGGPEAPIPPPPQPREKVSSIDLEIDSLSSLLDDMTKNDPFKARVSSGYVPPPV 177
P P P A P P ++ I S S+ + D + + SS P V
Sbjct: 315 PLLPASAQPPAAASPSAASPPLATAAAHTAIASASTTAPASSPADSPRPQASS--YSPAV 372
Query: 178 ATPFSSKSSTKPAAGGTAPLPPWK-------SPSSSQPLPQVPAPAQSQTQFHVQPQ-PQ 229
A + + T + G AP P + PS QP+P + P P
Sbjct: 373 AASSAPATHTSYSEGPAAPAPKPRVVTTASIRPSVYQPVPASTYSPSPGANYSPTPYTPS 432
Query: 230 PKPQVQLHVQSQTQPVSLANTQPRGPPASSPAPAPKFSPVT----------PKFTP---- 275
P P P + P PA +P+PAP ++P P P
Sbjct: 433 PAPAYTPSPAPAYTPSPVPTYTPSPAPAYTPSPAPNYNPAPSVAYSGGPAEPASRPPWVT 492
Query: 276 ---VASKFSPGAPGGSGSQPNQKLGHPEALSAGTGSPQPPSFTYAQQREKPRVQEKQHPV 332
+ KF+PG S S+ G P AG PQ P + R
Sbjct: 493 DDSFSQKFAPGKSTTSISKQTLPRGGPAYTPAG---PQVPPLARGTVQRAERFPASSR-T 548
Query: 333 PPPAQNQNQVRSPGAPGPLTLKEVEELE-QLTQQLMQDMEHPQRQNVAVNELCGRCHQ-- 389
P N +R P EE + + D+ + QN N C RC++
Sbjct: 549 PLCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQN---NVYCERCYEQF 605
Query: 390 --PLARA------QPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDTL 441
PL + AL Q +H CF C C + F+ +G PYCE Y +
Sbjct: 606 FAPLCAKCNTKIMGEVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLF 665
Query: 442 E-KCNTCGEPIT--DRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYH 497
KC+ C P+ D+ + A G +H CF C VC LEG F + +RP C H
Sbjct: 666 STKCHGCDFPVEAGDKFIEALGHTWHDTCFICAVCHVNLEGQPF-YSKKDRPLCKKHAH 723
Score = 33.9 bits (76), Expect = 0.41
Identities = 35/150 (23%), Positives = 50/150 (33%), Gaps = 18/150 (12%)
Query: 205 SSQPLPQVPAPAQSQTQFHVQPQPQPKPQVQLHVQSQTQPVSLANTQPRGPPASSPAPAP 264
SS P+ P T + QP S + A+T ++PA +P
Sbjct: 298 SSTPIEHAPVCTSQATTPLLPASAQPPAAASPSAASPPLATAAAHTAIASASTTAPASSP 357
Query: 265 KFSPVTPKFTPVASKFSPGAPGGSGSQPNQKLGHPEALSAGTGSPQPPSFTYAQQREKPR 324
SP P AS +SP S + + S G +P P +P
Sbjct: 358 ADSP-----RPQASSYSPAVAASSAPATH------TSYSEGPAAPAPKPRVVTTASIRPS 406
Query: 325 VQEKQHPVP----PPAQNQNQVRSPGAPGP 350
V + PVP P+ N +P P P
Sbjct: 407 VYQ---PVPASTYSPSPGANYSPTPYTPSP 433
Score = 29.6 bits (65), Expect = 7.8
Identities = 38/173 (21%), Positives = 64/173 (36%), Gaps = 39/173 (22%)
Query: 218 SQTQFHVQPQPQPKP---QVQLHVQSQTQPVSLANTQP------------RGPP------ 256
+ T H++ Q + K + L +Q +P+ ++ T P + P
Sbjct: 57 TDTMTHLEAQNKIKSASYNLSLTLQKSKRPIPISTTAPPVQTPLPVIPHQKDPALDTNGS 116
Query: 257 --ASSPAPAPKFSPVTPKFTPVASKFSPGAPGGSGSQPNQKLGHPEALS--AGTGSPQPP 312
A SP+P + SP TP + FSP P A S A P PP
Sbjct: 117 LVAPSPSPEARASPGTPGTPELRPTFSPA------------FSRPSAFSSLAEASDPGPP 164
Query: 313 SFTYAQQREKPRVQEKQHPVPPPAQNQ-NQVRSP-GAPGPLTLKEVEELEQLT 363
+ + ++ P P +Q Q +P G TL+E+ ++ Q++
Sbjct: 165 RASLRAKTSPEGARDLLGPKALPGSSQPRQYNNPIGLYSAETLREMAQMYQMS 217
>gi|13518026 LIM and senescent cell antigen-like domains 1 [Homo
sapiens]
Length = 325
Score = 102 bits (254), Expect = 9e-22
Identities = 61/196 (31%), Positives = 89/196 (45%), Gaps = 19/196 (9%)
Query: 377 NVAVNELCGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGC 436
N + C RC A A+ V + G+L+H CF C QC QQ FY EG YCE
Sbjct: 3 NALASATCERCKGGFAPAEKIVNSNGELYHEQCFVCAQCFQQFPEGLFYEFEGRKYCEHD 62
Query: 437 YTDTLEK-CNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPD 495
+ C+ CGE I R+++A ++HP CF C +C L F V A R C P
Sbjct: 63 FQMLFAPCCHQCGEFIIGRVIKAMNNSWHPECFRCDLCQEVLADIGF-VKNAGRHLCRPC 121
Query: 496 YHKQYAPR-----CSVCSEPIMPEPGRDETVRVVALDKNFHMKCYKCEDCGKPLSIEADD 550
++++ A C C I +P ++ + +H + C +CGK L+ +A +
Sbjct: 122 HNREKARGLGKYICQKCHAIIDEQP-------LIFKNDPYHPDHFNCANCGKELTADARE 174
Query: 551 NGCFPLDGHVLCRKCH 566
L G + C CH
Sbjct: 175 -----LKGELYCLPCH 185
Score = 69.7 bits (169), Expect = 7e-12
Identities = 48/185 (25%), Positives = 79/185 (42%), Gaps = 15/185 (8%)
Query: 383 LCGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDT-L 441
+C +CH + QP + +H F C C ++L L+G YC C+ +
Sbjct: 134 ICQKCHA-IIDEQPLIFK-NDPYHPDHFNCANCGKELTADA-RELKGELYCLPCHDKMGV 190
Query: 442 EKCNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHKQYA 501
C C PI R++ A GK +H F C C +P G ++ +C Y++ +
Sbjct: 191 PICGACRRPIEGRVVNAMGKQWHVEHFVCAKCEKPFLGHRH-YERKGLAYCETHYNQLFG 249
Query: 502 PRCSVCSEPIMPEPGRDETVRVVALDKNFHMKCYKCEDCGKPLSIEADDNGCFPLDGHVL 561
C C+ I E V AL+K + + C+ C C L+++ N D +
Sbjct: 250 DVCFHCNRVI-------EGDVVSALNKAWCVNCFACSTCNTKLTLK---NKFVEFDMKPV 299
Query: 562 CRKCH 566
C+KC+
Sbjct: 300 CKKCY 304
Score = 63.2 bits (152), Expect = 6e-10
Identities = 34/117 (29%), Positives = 53/117 (45%), Gaps = 3/117 (2%)
Query: 383 LCGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDTL- 441
+CG C +P+ V A+G+ +H+ F C +C + G + Y +G YCE Y
Sbjct: 192 ICGACRRPIEGR--VVNAMGKQWHVEHFVCAKCEKPFLGHRHYERKGLAYCETHYNQLFG 249
Query: 442 EKCNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHK 498
+ C C I ++ A KA+ +CF C C L + V+ +P C Y K
Sbjct: 250 DVCFHCNRVIEGDVVSALNKAWCVNCFACSTCNTKLTLKNKFVEFDMKPVCKKCYEK 306
>gi|170932514 paxillin isoform 1 [Homo sapiens]
Length = 591
Score = 99.4 bits (246), Expect = 8e-21
Identities = 104/458 (22%), Positives = 169/458 (36%), Gaps = 53/458 (11%)
Query: 110 EEEIFPSPPPPPEEEGGPEAPIPPPPQPREKVSSIDLEIDSLSSLLDDMTKNDP-FKARV 168
EE ++ P E P P + S E+D L L+ + N P F A
Sbjct: 114 EEHVYSFPNKQKSAE-------PSPTVMSTSLGSNLSELDRLLLELNAVQHNPPGFPADE 166
Query: 169 SSGYVPPPVATP--FSSKSSTKPAAGGTAPLPPWKSP-SSSQPLPQVPAPAQSQTQFHVQ 225
++ P P A + + P G PL K + + L V +S
Sbjct: 167 ANSSPPLPGALSPLYGVPETNSPLGGKAGPLTKEKPKRNGGRGLEDVRPSVESLLDELES 226
Query: 226 PQPQPKPQVQLHVQSQTQPVSLANTQPRGPPASSPAPAPKFSPVTPKFTPVASKFSPGAP 285
P P P + ++ + P + +TQ + ++S A T + + + S
Sbjct: 227 SVPSPVPAITVNQGEMSSPQRVTSTQQQTRISASSA--------TRELDELMASLSDFKI 278
Query: 286 GGSGSQPNQKLGHPEALSAGTGSPQPPSFTYAQQREKPRVQEKQHPVPPPAQNQNQVRSP 345
G Q+ +AG S Q Q K PP P
Sbjct: 279 QGL----EQRADGERCWAAGWPRDGGRSSPGGQDEGGFMAQGKTGSSSPPG-------GP 327
Query: 346 GAPGPLTLKEVEELEQLTQQLMQDMEHPQRQNVAVNELCGRCHQPLARAQPAVRALGQLF 405
PG +L+ + L D+ VA +CG C +P+A V A+G+ +
Sbjct: 328 PKPG-------SQLDSMLGSLQSDLNKLGVATVAKG-VCGACKKPIAGQ--VVTAMGKTW 377
Query: 406 HIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDTLE-KCNTCGEPITDRMLRATGKAYH 464
H F C C +++ + F+ +G PYCE Y + +C C PI D+++ A + +H
Sbjct: 378 HPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPRCYYCNGPILDKVVTALDRTWH 437
Query: 465 PHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHKQYAPRCSVCSEPIMPEPGRDETVRVV 524
P F C C G ++ + +C DY +AP+C C+ I+ +
Sbjct: 438 PEHFFCAQCG-AFFGPEGFHEKDGKAYCRKDYFDMFAPKCGGCARAILEN-------YIS 489
Query: 525 ALDKNFHMKCYKCEDCGKPLSIEADDNGCFPLDGHVLC 562
AL+ +H +C+ C +C P + F DG C
Sbjct: 490 ALNTLWHPECFVCRECFTPFV----NGSFFEHDGQPYC 523
Score = 82.0 bits (201), Expect = 1e-15
Identities = 50/163 (30%), Positives = 71/163 (43%), Gaps = 11/163 (6%)
Query: 384 CGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDTLE- 442
C C+ P+ V AL + +H F C QC + F+ +G YC Y D
Sbjct: 417 CYYCNGPIL--DKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFAP 474
Query: 443 KCNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHKQYAP 502
KC C I + + A +HP CF C C P SF + +P+C YH++
Sbjct: 475 KCGGCARAILENYISALNTLWHPECFVCRECFTPFVNGSFF-EHDGQPYCEVHYHERRGS 533
Query: 503 RCSVCSEPIMPEPGRDETVRVVALDKNFHMKCYKCEDCGKPLS 545
CS C +PI GR + A+ K FH + + C C K L+
Sbjct: 534 LCSGCQKPI---TGR----CITAMAKKFHPEHFVCAFCLKQLN 569
Score = 72.4 bits (176), Expect = 1e-12
Identities = 36/110 (32%), Positives = 55/110 (50%), Gaps = 4/110 (3%)
Query: 384 CGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDTLEK 443
CG C + + + + AL L+H CF C +C F+ +G PYCE Y +
Sbjct: 476 CGGCARAIL--ENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGS 533
Query: 444 -CNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHC 492
C+ C +PIT R + A K +HP F C C + L +F +Q ++P+C
Sbjct: 534 LCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLNKGTF-KEQNDKPYC 582
Score = 38.5 bits (88), Expect = 0.017
Identities = 17/55 (30%), Positives = 25/55 (45%), Gaps = 2/55 (3%)
Query: 383 LCGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCY 437
LC C +P+ + A+ + FH F C C +QL F PYC+ C+
Sbjct: 534 LCSGCQKPITGR--CITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQNCF 586
>gi|122056614 LIM domain binding 3 isoform 2 [Homo sapiens]
Length = 617
Score = 99.0 bits (245), Expect = 1e-20
Identities = 100/405 (24%), Positives = 150/405 (37%), Gaps = 62/405 (15%)
Query: 165 KARVSSGYVPPPVATPFSSKSSTKPAAGGTAPLPPWKSPSSSQPLPQVPAPAQSQTQFHV 224
++R + P VA + + T + G AP P + +++ P V P + T
Sbjct: 250 RSRPQASSYSPAVAASSAPATHTSYSEGPAAPAPKPRVVTTASIRPSVYQPVPASTY--- 306
Query: 225 QPQPQPKPQVQLHVQSQTQPVSLANTQPRGPPASSPAPAPKFSPV-TPKFTPVASKFSPG 283
P P T P PA +P+PAP ++P P +TP SP
Sbjct: 307 ----SPSPGANYSPTPYT---------PSPAPAYTPSPAPAYTPSPVPTYTP-----SPA 348
Query: 284 APGGSGSQPNQKLGHPEALSAGTGSP--QPPSFT-------YAQQREKPRVQEKQHPVPP 334
PN A S G P +PP T +A + + ++ P
Sbjct: 349 PAYTPSPAPNYNPAPSVAYSGGPAEPASRPPWVTDDSFSQKFAPGKSTTSISKQTLPRGG 408
Query: 335 PAQNQNQVRSPGAPGPLTLKEVEELEQLTQQLMQDMEHPQRQNVAVNELCGRCHQPLARA 394
PA +P P +V L + T Q + R LCG C+ +
Sbjct: 409 PAY------TPAGP------QVPPLARGTVQRAERFPASSR-----TPLCGHCNNVIRG- 450
Query: 395 QPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDTLEK-CNTCGEPITD 453
P + A+G+ +H FTC C L F + YCE CY C C I
Sbjct: 451 -PFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKCNTKIMG 509
Query: 454 RMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHKQYAPRCSVCSEPIMP 513
++ A + +H CF C C +P G S + P+C DY ++ +C C P+
Sbjct: 510 EVMHALRQTWHTTCFVCAACKKPF-GNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPV-- 566
Query: 514 EPGRDETVRVVALDKNFHMKCYKCEDC-----GKPLSIEADDNGC 553
E G D+ + AL +H C+ C C G+P + D C
Sbjct: 567 EAG-DKFIE--ALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLC 608
Score = 51.2 bits (121), Expect = 3e-06
Identities = 87/379 (22%), Positives = 130/379 (34%), Gaps = 51/379 (13%)
Query: 95 PPPPPIEESFPPAPLEEEIFPSPPPPPEEEGGPEAPIPPPPQPREKVSSIDLEIDSLSSL 154
P + S P A + P E P P P+PR ++ S+
Sbjct: 243 PDEEALRRSRPQASSYSPAVAASSAPATHTSYSEGPAAPAPKPRVVTTA------SIRPS 296
Query: 155 LDDMTKNDPFKARVSSGYVPPPVATPFSSKSSTKPAAGGTAPLP-PWKSPSSS-----QP 208
+ + + Y P P TP + + T A P P P +PS + P
Sbjct: 297 VYQPVPASTYSPSPGANYSPTPY-TPSPAPAYTPSPAPAYTPSPVPTYTPSPAPAYTPSP 355
Query: 209 LPQV-PAPAQSQTQFHVQPQPQPKPQVQLHVQSQ-------TQPVSLANTQPRGPPASSP 260
P PAP+ + + +P +P P V SQ T +S T PRG PA +P
Sbjct: 356 APNYNPAPSVAYSGGPAEPASRP-PWVTDDSFSQKFAPGKSTTSIS-KQTLPRGGPAYTP 413
Query: 261 APAPKFSPVTPKFTPVASKFSPGAPGGSGSQPNQKLGHPEALSAGTGSPQPPSFTYAQQR 320
A P+ P+ A +F + N + P ++ G S P FT A +
Sbjct: 414 A-GPQVPPLARGTVQRAERFPASSRTPLCGHCNNVIRGPFLVAMGR-SWHPEEFTCAYCK 471
Query: 321 EKPR----VQEKQHPVPPPAQNQNQVRSPGAPGPLTLKEVEELEQLTQQL---------- 366
V+E+ + Q + EV + T
Sbjct: 472 TSLADVCFVEEQNNVYCERCYEQFFAPLCAKCNTKIMGEVMHALRQTWHTTCFVCAACKK 531
Query: 367 --------MQDMEHPQRQNVAVNELCGRCHQ---PLARAQPAVRALGQLFHIACFTCHQC 415
M+D E P + +N +CH P+ + ALG +H CF C C
Sbjct: 532 PFGNSLFHMEDGE-PYCEKDYINLFSTKCHGCDFPVEAGDKFIEALGHTWHDTCFICAVC 590
Query: 416 AQQLQGQQFYSLEGAPYCE 434
L+GQ FYS + P C+
Sbjct: 591 HVNLEGQPFYSKKDRPLCK 609
Score = 42.0 bits (97), Expect = 0.002
Identities = 51/199 (25%), Positives = 69/199 (34%), Gaps = 30/199 (15%)
Query: 7 SPAISVSVSAPAFYAPQKKFGPVVAPKPKV---NPFRPGDSEPPPA------PGAQRAQM 57
SPA++ S SAPA + + APKP+V RP +P PA PGA +
Sbjct: 259 SPAVAAS-SAPATHTSYSEGPAAPAPKPRVVTTASIRPSVYQPVPASTYSPSPGANYSPT 317
Query: 58 GRVGEIPPPPPEDFPLPPPPLAGDGDDAEGALGGAFPPPPPPIEESFPPAPLEEEIFPS- 116
P P P P P P A+ P P P P P+
Sbjct: 318 PYT---PSPAPAYTPSPAP---------------AYTPSPVPTYTPSPAPAYTPSPAPNY 359
Query: 117 -PPPPPEEEGGPEAPIPPPPQPREKVSSIDLEIDSLSSLLDDMTKNDPFKARVSSGYVPP 175
P P GGP P PP + S ++ + T A +G P
Sbjct: 360 NPAPSVAYSGGPAEPASRPPWVTDDSFSQKFAPGKSTTSISKQTLPRGGPAYTPAGPQVP 419
Query: 176 PVATPFSSKSSTKPAAGGT 194
P+A ++ PA+ T
Sbjct: 420 PLARGTVQRAERFPASSRT 438
>gi|54112385 four and a half LIM domains 3 [Homo sapiens]
Length = 280
Score = 98.2 bits (243), Expect = 2e-20
Identities = 55/194 (28%), Positives = 85/194 (43%), Gaps = 16/194 (8%)
Query: 384 CGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDTL-E 442
C C Q + + + FH CF C +C + L + F + C CY
Sbjct: 40 CAECQQLIGHDSRELFYEDRHFHEGCFRCCRCQRSLADEPFTCQDSELLCNDCYCSAFSS 99
Query: 443 KCNTCGEPIT--DRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHKQY 500
+C+ CGE + R L G+ +H HCF C C +PL SF+ D+ +CVP Y ++
Sbjct: 100 QCSACGETVMPGSRKLEYGGQTWHEHCFLCSGCEQPLGSRSFVPDKGAH-YCVPCYENKF 158
Query: 501 APRCSVCSEPIMPEPGRDETVRVVALDKNFHMKCYKCEDCGKPLSIEA-----DDNGCFP 555
APRC+ CS+ + V D+ +H +C C C PL+ + +D C
Sbjct: 159 APRCARCSKTLTQG-------GVTYRDQPWHRECLVCTGCQTPLAGQQFTSRDEDPYCVA 211
Query: 556 LDGHVLCRKCHTAR 569
G + KC + +
Sbjct: 212 CFGELFAPKCSSCK 225
Score = 94.4 bits (233), Expect = 3e-19
Identities = 55/191 (28%), Positives = 81/191 (42%), Gaps = 9/191 (4%)
Query: 379 AVNELCGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYT 438
A + C C + + + GQ +H CF C C Q L + F +GA YC CY
Sbjct: 96 AFSSQCSACGETVMPGSRKLEYGGQTWHEHCFLCSGCEQPLGSRSFVPDKGAHYCVPCYE 155
Query: 439 DTL-EKCNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYH 497
+ +C C + +T + + +H C C C PL G F + P+CV +
Sbjct: 156 NKFAPRCARCSKTLTQGGVTYRDQPWHRECLVCTGCQTPLAGQQF-TSRDEDPYCVACFG 214
Query: 498 KQYAPRCSVCSEPIMPEPGRDETVRVVALDKNFHMKCYKCEDCGKPLSIEADDNGCFPLD 557
+ +AP+CS C PI+ G V D+++H C+ C C L G P
Sbjct: 215 ELFAPKCSSCKRPIV---GLGGGKYVSFEDRHWHHNCFSCARCSTSLV----GQGFVPDG 267
Query: 558 GHVLCRKCHTA 568
VLC+ C A
Sbjct: 268 DQVLCQGCSQA 278
Score = 68.2 bits (165), Expect = 2e-11
Identities = 41/140 (29%), Positives = 60/140 (42%), Gaps = 13/140 (9%)
Query: 410 FTCHQCAQQLQGQQFYSLEGAPYCEGCYTDTLEKCNTCGE-----PITDRMLRATGKAYH 464
F C +C + L G+++ + PYC CY +T NTC E R L + +H
Sbjct: 5 FDCAKCNESLYGRKYIQTDSGPYCVPCYDNTF--ANTCAECQQLIGHDSRELFYEDRHFH 62
Query: 465 PHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHKQYAPRCSVCSEPIMPEPGRDETVRVV 524
CF C C R L F Q + C Y ++ +CS C E +MP + E
Sbjct: 63 EGCFRCCRCQRSLADEPFTC-QDSELLCNDCYCSAFSSQCSACGETVMPGSRKLEYG--- 118
Query: 525 ALDKNFHMKCYKCEDCGKPL 544
+ +H C+ C C +PL
Sbjct: 119 --GQTWHEHCFLCSGCEQPL 136
>gi|170932518 paxillin isoform 3 [Homo sapiens]
Length = 424
Score = 97.4 bits (241), Expect = 3e-20
Identities = 87/344 (25%), Positives = 137/344 (39%), Gaps = 42/344 (12%)
Query: 244 PVSLANTQPRGPPASSPA-PAPKF-SPVTPKFTPVASKFSPGAPGGSGSQPNQKLGHP-- 299
P AN+ P P A SP P+ SP+ K P+ +K P GG G + +
Sbjct: 30 PADEANSSPPLPGALSPLYGVPETNSPLGGKAGPL-TKEKPKRNGGRGLEDVRPSVESLL 88
Query: 300 EALSAGTGSPQPPSFTYAQQREKP-RVQEKQHPVPPPAQN-------------------Q 339
+ L + SP P + P RV Q A + Q
Sbjct: 89 DELESSVPSPVPAITVNQGEMSSPQRVTSTQQQTRISASSATRELDELMASLSDFKFMAQ 148
Query: 340 NQVRSPGAPGPLTLKEVEELEQLTQQLMQDMEHPQRQNVAVNELCGRCHQPLARAQPAVR 399
+ S PG K +L+ + L D+ VA +CG C +P+A V
Sbjct: 149 GKTGSSSPPGGPP-KPGSQLDSMLGSLQSDLNKLGVATVAKG-VCGACKKPIAGQ--VVT 204
Query: 400 ALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDTLE-KCNTCGEPITDRMLRA 458
A+G+ +H F C C +++ + F+ +G PYCE Y + +C C PI D+++ A
Sbjct: 205 AMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPRCYYCNGPILDKVVTA 264
Query: 459 TGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHKQYAPRCSVCSEPIMPEPGRD 518
+ +HP F C C G ++ + +C DY +AP+C C+ I+
Sbjct: 265 LDRTWHPEHFFCAQCG-AFFGPEGFHEKDGKAYCRKDYFDMFAPKCGGCARAILEN---- 319
Query: 519 ETVRVVALDKNFHMKCYKCEDCGKPLSIEADDNGCFPLDGHVLC 562
+ AL+ +H +C+ C +C P + F DG C
Sbjct: 320 ---YISALNTLWHPECFVCRECFTPFV----NGSFFEHDGQPYC 356
Score = 82.0 bits (201), Expect = 1e-15
Identities = 50/163 (30%), Positives = 71/163 (43%), Gaps = 11/163 (6%)
Query: 384 CGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDTLE- 442
C C+ P+ V AL + +H F C QC + F+ +G YC Y D
Sbjct: 250 CYYCNGPIL--DKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFAP 307
Query: 443 KCNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHKQYAP 502
KC C I + + A +HP CF C C P SF + +P+C YH++
Sbjct: 308 KCGGCARAILENYISALNTLWHPECFVCRECFTPFVNGSFF-EHDGQPYCEVHYHERRGS 366
Query: 503 RCSVCSEPIMPEPGRDETVRVVALDKNFHMKCYKCEDCGKPLS 545
CS C +PI GR + A+ K FH + + C C K L+
Sbjct: 367 LCSGCQKPI---TGR----CITAMAKKFHPEHFVCAFCLKQLN 402
Score = 72.4 bits (176), Expect = 1e-12
Identities = 36/110 (32%), Positives = 55/110 (50%), Gaps = 4/110 (3%)
Query: 384 CGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDTLEK 443
CG C + + + + AL L+H CF C +C F+ +G PYCE Y +
Sbjct: 309 CGGCARAIL--ENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGS 366
Query: 444 -CNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHC 492
C+ C +PIT R + A K +HP F C C + L +F +Q ++P+C
Sbjct: 367 LCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLNKGTF-KEQNDKPYC 415
Score = 38.5 bits (88), Expect = 0.017
Identities = 17/55 (30%), Positives = 25/55 (45%), Gaps = 2/55 (3%)
Query: 383 LCGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCY 437
LC C +P+ + A+ + FH F C C +QL F PYC+ C+
Sbjct: 367 LCSGCQKPITGR--CITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQNCF 419
>gi|170932516 paxillin isoform 2 [Homo sapiens]
Length = 557
Score = 97.4 bits (241), Expect = 3e-20
Identities = 87/344 (25%), Positives = 137/344 (39%), Gaps = 42/344 (12%)
Query: 244 PVSLANTQPRGPPASSPA-PAPKF-SPVTPKFTPVASKFSPGAPGGSGSQPNQKLGHP-- 299
P AN+ P P A SP P+ SP+ K P+ +K P GG G + +
Sbjct: 163 PADEANSSPPLPGALSPLYGVPETNSPLGGKAGPL-TKEKPKRNGGRGLEDVRPSVESLL 221
Query: 300 EALSAGTGSPQPPSFTYAQQREKP-RVQEKQHPVPPPAQN-------------------Q 339
+ L + SP P + P RV Q A + Q
Sbjct: 222 DELESSVPSPVPAITVNQGEMSSPQRVTSTQQQTRISASSATRELDELMASLSDFKFMAQ 281
Query: 340 NQVRSPGAPGPLTLKEVEELEQLTQQLMQDMEHPQRQNVAVNELCGRCHQPLARAQPAVR 399
+ S PG K +L+ + L D+ VA +CG C +P+A V
Sbjct: 282 GKTGSSSPPGGPP-KPGSQLDSMLGSLQSDLNKLGVATVAKG-VCGACKKPIAGQ--VVT 337
Query: 400 ALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDTLE-KCNTCGEPITDRMLRA 458
A+G+ +H F C C +++ + F+ +G PYCE Y + +C C PI D+++ A
Sbjct: 338 AMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPRCYYCNGPILDKVVTA 397
Query: 459 TGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHKQYAPRCSVCSEPIMPEPGRD 518
+ +HP F C C G ++ + +C DY +AP+C C+ I+
Sbjct: 398 LDRTWHPEHFFCAQCG-AFFGPEGFHEKDGKAYCRKDYFDMFAPKCGGCARAILEN---- 452
Query: 519 ETVRVVALDKNFHMKCYKCEDCGKPLSIEADDNGCFPLDGHVLC 562
+ AL+ +H +C+ C +C P + F DG C
Sbjct: 453 ---YISALNTLWHPECFVCRECFTPFV----NGSFFEHDGQPYC 489
Score = 82.0 bits (201), Expect = 1e-15
Identities = 50/163 (30%), Positives = 71/163 (43%), Gaps = 11/163 (6%)
Query: 384 CGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDTLE- 442
C C+ P+ V AL + +H F C QC + F+ +G YC Y D
Sbjct: 383 CYYCNGPIL--DKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFAP 440
Query: 443 KCNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHKQYAP 502
KC C I + + A +HP CF C C P SF + +P+C YH++
Sbjct: 441 KCGGCARAILENYISALNTLWHPECFVCRECFTPFVNGSFF-EHDGQPYCEVHYHERRGS 499
Query: 503 RCSVCSEPIMPEPGRDETVRVVALDKNFHMKCYKCEDCGKPLS 545
CS C +PI GR + A+ K FH + + C C K L+
Sbjct: 500 LCSGCQKPI---TGR----CITAMAKKFHPEHFVCAFCLKQLN 535
Score = 72.4 bits (176), Expect = 1e-12
Identities = 36/110 (32%), Positives = 55/110 (50%), Gaps = 4/110 (3%)
Query: 384 CGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDTLEK 443
CG C + + + + AL L+H CF C +C F+ +G PYCE Y +
Sbjct: 442 CGGCARAIL--ENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGS 499
Query: 444 -CNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHC 492
C+ C +PIT R + A K +HP F C C + L +F +Q ++P+C
Sbjct: 500 LCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLNKGTF-KEQNDKPYC 548
Score = 38.5 bits (88), Expect = 0.017
Identities = 17/55 (30%), Positives = 25/55 (45%), Gaps = 2/55 (3%)
Query: 383 LCGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCY 437
LC C +P+ + A+ + FH F C C +QL F PYC+ C+
Sbjct: 500 LCSGCQKPITGR--CITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQNCF 552
>gi|51173715 actin-binding LIM protein 1 isoform c [Homo sapiens]
Length = 746
Score = 95.5 bits (236), Expect = 1e-19
Identities = 68/226 (30%), Positives = 92/226 (40%), Gaps = 49/226 (21%)
Query: 368 QDMEHPQRQNVAVNELCGR-CHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYS 426
QD HP + V CG C + R Q + FHI CFTC C L F+
Sbjct: 26 QDPHHPSEKPVIHCHKCGEPCKGEVLRVQT------KHFHIKCFTCKVCGCDLAQGGFFI 79
Query: 427 LEGAPYCEGCYTDTL-EKCNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVD 485
G C Y +C+ CGE + ++ A GK YHP+CF C +C RP +
Sbjct: 80 KNGEYLCTLDYQRMYGTRCHGCGEFVEGEVVTALGKTYHPNCFACTICKRPFPPGDRVT- 138
Query: 486 QANRPHCVPDYHKQYAPRCSVCSEPIMPEP------------GRD--ETVRVVALDKNFH 531
N C+ C +C++P+ P GRD ++ALDK +H
Sbjct: 139 -FNGRDCL----------CQLCAQPMSSSPKETTFSSNCAGCGRDIKNGQALLALDKQWH 187
Query: 532 MKCYKCEDCGKPLS-----------IEADDNGCFPLDGHVLCRKCH 566
+ C+KC+ CGK L+ E D G F V C CH
Sbjct: 188 LGCFKCKSCGKVLTGEYISKDGAPYCEKDYQGLF----GVKCEACH 229
Score = 68.2 bits (165), Expect = 2e-11
Identities = 46/133 (34%), Positives = 64/133 (48%), Gaps = 8/133 (6%)
Query: 343 RSPGAPGP-LTLKEVEELEQLTQQLMQDMEHPQRQNVAVNELCGRCHQPLARAQPAVRAL 401
+ P PG +T + L QL Q M P+ + N C C + + Q A+ AL
Sbjct: 128 KRPFPPGDRVTFNGRDCLCQLCAQPMSSS--PKETTFSSN--CAGCGRDIKNGQ-ALLAL 182
Query: 402 GQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDTLE-KCNTCGEPITDRMLRATG 460
+ +H+ CF C C + L G+ + S +GAPYCE Y KC C + IT ++L A
Sbjct: 183 DKQWHLGCFKCKSCGKVLTGE-YISKDGAPYCEKDYQGLFGVKCEACHQFITGKVLEAGD 241
Query: 461 KAYHPHCFTCVVC 473
K YHP C C C
Sbjct: 242 KHYHPSCARCSRC 254
Score = 61.2 bits (147), Expect = 2e-09
Identities = 45/157 (28%), Positives = 64/157 (40%), Gaps = 22/157 (14%)
Query: 398 VRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAP-YCEGCY---------TDTLEKCNTC 447
V ALG+ +H CF C C + + G C+ C T C C
Sbjct: 110 VTALGKTYHPNCFACTICKRPFPPGDRVTFNGRDCLCQLCAQPMSSSPKETTFSSNCAGC 169
Query: 448 GEPITD-RMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHKQYAPRCSV 506
G I + + L A K +H CF C C + L G D A P+C DY + +C
Sbjct: 170 GRDIKNGQALLALDKQWHLGCFKCKSCGKVLTGEYISKDGA--PYCEKDYQGLFGVKCEA 227
Query: 507 CSEPIMPEPGRDETVRVV-ALDKNFHMKCYKCEDCGK 542
C + I T +V+ A DK++H C +C C +
Sbjct: 228 CHQFI--------TGKVLEAGDKHYHPSCARCSRCNQ 256
>gi|51173713 actin-binding LIM protein 1 isoform b [Homo sapiens]
Length = 718
Score = 95.5 bits (236), Expect = 1e-19
Identities = 68/226 (30%), Positives = 92/226 (40%), Gaps = 49/226 (21%)
Query: 368 QDMEHPQRQNVAVNELCGR-CHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYS 426
QD HP + V CG C + R Q + FHI CFTC C L F+
Sbjct: 26 QDPHHPSEKPVIHCHKCGEPCKGEVLRVQT------KHFHIKCFTCKVCGCDLAQGGFFI 79
Query: 427 LEGAPYCEGCYTDTL-EKCNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVD 485
G C Y +C+ CGE + ++ A GK YHP+CF C +C RP +
Sbjct: 80 KNGEYLCTLDYQRMYGTRCHGCGEFVEGEVVTALGKTYHPNCFACTICKRPFPPGDRVT- 138
Query: 486 QANRPHCVPDYHKQYAPRCSVCSEPIMPEP------------GRD--ETVRVVALDKNFH 531
N C+ C +C++P+ P GRD ++ALDK +H
Sbjct: 139 -FNGRDCL----------CQLCAQPMSSSPKETTFSSNCAGCGRDIKNGQALLALDKQWH 187
Query: 532 MKCYKCEDCGKPLS-----------IEADDNGCFPLDGHVLCRKCH 566
+ C+KC+ CGK L+ E D G F V C CH
Sbjct: 188 LGCFKCKSCGKVLTGEYISKDGAPYCEKDYQGLF----GVKCEACH 229
Score = 68.2 bits (165), Expect = 2e-11
Identities = 46/133 (34%), Positives = 64/133 (48%), Gaps = 8/133 (6%)
Query: 343 RSPGAPGP-LTLKEVEELEQLTQQLMQDMEHPQRQNVAVNELCGRCHQPLARAQPAVRAL 401
+ P PG +T + L QL Q M P+ + N C C + + Q A+ AL
Sbjct: 128 KRPFPPGDRVTFNGRDCLCQLCAQPMSSS--PKETTFSSN--CAGCGRDIKNGQ-ALLAL 182
Query: 402 GQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDTLE-KCNTCGEPITDRMLRATG 460
+ +H+ CF C C + L G+ + S +GAPYCE Y KC C + IT ++L A
Sbjct: 183 DKQWHLGCFKCKSCGKVLTGE-YISKDGAPYCEKDYQGLFGVKCEACHQFITGKVLEAGD 241
Query: 461 KAYHPHCFTCVVC 473
K YHP C C C
Sbjct: 242 KHYHPSCARCSRC 254
Score = 61.2 bits (147), Expect = 2e-09
Identities = 45/157 (28%), Positives = 64/157 (40%), Gaps = 22/157 (14%)
Query: 398 VRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAP-YCEGCY---------TDTLEKCNTC 447
V ALG+ +H CF C C + + G C+ C T C C
Sbjct: 110 VTALGKTYHPNCFACTICKRPFPPGDRVTFNGRDCLCQLCAQPMSSSPKETTFSSNCAGC 169
Query: 448 GEPITD-RMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHKQYAPRCSV 506
G I + + L A K +H CF C C + L G D A P+C DY + +C
Sbjct: 170 GRDIKNGQALLALDKQWHLGCFKCKSCGKVLTGEYISKDGA--PYCEKDYQGLFGVKCEA 227
Query: 507 CSEPIMPEPGRDETVRVV-ALDKNFHMKCYKCEDCGK 542
C + I T +V+ A DK++H C +C C +
Sbjct: 228 CHQFI--------TGKVLEAGDKHYHPSCARCSRCNQ 256
>gi|51173711 actin-binding LIM protein 1 isoform a [Homo sapiens]
Length = 778
Score = 95.5 bits (236), Expect = 1e-19
Identities = 68/226 (30%), Positives = 92/226 (40%), Gaps = 49/226 (21%)
Query: 368 QDMEHPQRQNVAVNELCGR-CHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYS 426
QD HP + V CG C + R Q + FHI CFTC C L F+
Sbjct: 86 QDPHHPSEKPVIHCHKCGEPCKGEVLRVQT------KHFHIKCFTCKVCGCDLAQGGFFI 139
Query: 427 LEGAPYCEGCYTDTL-EKCNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVD 485
G C Y +C+ CGE + ++ A GK YHP+CF C +C RP +
Sbjct: 140 KNGEYLCTLDYQRMYGTRCHGCGEFVEGEVVTALGKTYHPNCFACTICKRPFPPGDRVT- 198
Query: 486 QANRPHCVPDYHKQYAPRCSVCSEPIMPEP------------GRD--ETVRVVALDKNFH 531
N C+ C +C++P+ P GRD ++ALDK +H
Sbjct: 199 -FNGRDCL----------CQLCAQPMSSSPKETTFSSNCAGCGRDIKNGQALLALDKQWH 247
Query: 532 MKCYKCEDCGKPLS-----------IEADDNGCFPLDGHVLCRKCH 566
+ C+KC+ CGK L+ E D G F V C CH
Sbjct: 248 LGCFKCKSCGKVLTGEYISKDGAPYCEKDYQGLF----GVKCEACH 289
Score = 68.2 bits (165), Expect = 2e-11
Identities = 46/133 (34%), Positives = 64/133 (48%), Gaps = 8/133 (6%)
Query: 343 RSPGAPGP-LTLKEVEELEQLTQQLMQDMEHPQRQNVAVNELCGRCHQPLARAQPAVRAL 401
+ P PG +T + L QL Q M P+ + N C C + + Q A+ AL
Sbjct: 188 KRPFPPGDRVTFNGRDCLCQLCAQPMSSS--PKETTFSSN--CAGCGRDIKNGQ-ALLAL 242
Query: 402 GQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDTLE-KCNTCGEPITDRMLRATG 460
+ +H+ CF C C + L G+ + S +GAPYCE Y KC C + IT ++L A
Sbjct: 243 DKQWHLGCFKCKSCGKVLTGE-YISKDGAPYCEKDYQGLFGVKCEACHQFITGKVLEAGD 301
Query: 461 KAYHPHCFTCVVC 473
K YHP C C C
Sbjct: 302 KHYHPSCARCSRC 314
Score = 61.2 bits (147), Expect = 2e-09
Identities = 45/157 (28%), Positives = 64/157 (40%), Gaps = 22/157 (14%)
Query: 398 VRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAP-YCEGCY---------TDTLEKCNTC 447
V ALG+ +H CF C C + + G C+ C T C C
Sbjct: 170 VTALGKTYHPNCFACTICKRPFPPGDRVTFNGRDCLCQLCAQPMSSSPKETTFSSNCAGC 229
Query: 448 GEPITD-RMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHKQYAPRCSV 506
G I + + L A K +H CF C C + L G D A P+C DY + +C
Sbjct: 230 GRDIKNGQALLALDKQWHLGCFKCKSCGKVLTGEYISKDGA--PYCEKDYQGLFGVKCEA 287
Query: 507 CSEPIMPEPGRDETVRVV-ALDKNFHMKCYKCEDCGK 542
C + I T +V+ A DK++H C +C C +
Sbjct: 288 CHQFI--------TGKVLEAGDKHYHPSCARCSRCNQ 316
>gi|238859658 LIM and senescent cell antigen-like domains 2 isoform
1 [Homo sapiens]
Length = 363
Score = 94.7 bits (234), Expect = 2e-19
Identities = 59/192 (30%), Positives = 85/192 (44%), Gaps = 19/192 (9%)
Query: 381 NELCGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDT 440
N +C RC + A+ V + G+L+H CF C QC + FY EG YCE +
Sbjct: 34 NAVCQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQML 93
Query: 441 LEK-CNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHKQ 499
C +CGE I R+++A +HP CF C +C L F V A R C P ++++
Sbjct: 94 FAPCCGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGF-VKNAGRHLCRPCHNRE 152
Query: 500 YAPR-----CSVCSEPIMPEPGRDETVRVVALDKNFHMKCYKCEDCGKPLSIEADDNGCF 554
A C C I +P ++ +H + C CGK L+ EA +
Sbjct: 153 KAKGLGKYICQRCHLVIDEQP-------LMFRSDAYHPDHFNCTHCGKELTAEARE---- 201
Query: 555 PLDGHVLCRKCH 566
L G + C CH
Sbjct: 202 -LKGELYCLPCH 212
Score = 69.3 bits (168), Expect = 9e-12
Identities = 46/166 (27%), Positives = 66/166 (39%), Gaps = 17/166 (10%)
Query: 384 CGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDTLEK 443
CG C + + ++A+ +H CF C C +L F G C C+ K
Sbjct: 98 CGSCGEFIIGR--VIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKAK 155
Query: 444 ------CNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYH 497
C C I ++ L AYHP F C C + L T+ + +C+P +
Sbjct: 156 GLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKEL--TAEARELKGELYCLPCHD 213
Query: 498 KQYAPRCSVCSEPIMPEPGRDETVRVVALDKNFHMKCYKCEDCGKP 543
K P C C PI E V AL K +H++ + C C KP
Sbjct: 214 KMGVPICGACRRPI-------EGRVVNALGKQWHVEHFVCAKCEKP 252
Score = 64.3 bits (155), Expect = 3e-10
Identities = 35/117 (29%), Positives = 53/117 (45%), Gaps = 3/117 (2%)
Query: 383 LCGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDTL- 441
+CG C +P+ V ALG+ +H+ F C +C + G + Y +G YCE Y
Sbjct: 219 ICGACRRPIEGR--VVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFG 276
Query: 442 EKCNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHK 498
+ C C I ++ A KA+ CF+C C L + V+ +P C Y K
Sbjct: 277 DVCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCYEK 333
>gi|238776788 LIM and senescent cell antigen-like domains 2 isoform
5 [Homo sapiens]
Length = 336
Score = 94.7 bits (234), Expect = 2e-19
Identities = 59/192 (30%), Positives = 85/192 (44%), Gaps = 19/192 (9%)
Query: 381 NELCGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDT 440
N +C RC + A+ V + G+L+H CF C QC + FY EG YCE +
Sbjct: 7 NAVCQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQML 66
Query: 441 LEK-CNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHKQ 499
C +CGE I R+++A +HP CF C +C L F V A R C P ++++
Sbjct: 67 FAPCCGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGF-VKNAGRHLCRPCHNRE 125
Query: 500 YAPR-----CSVCSEPIMPEPGRDETVRVVALDKNFHMKCYKCEDCGKPLSIEADDNGCF 554
A C C I +P ++ +H + C CGK L+ EA +
Sbjct: 126 KAKGLGKYICQRCHLVIDEQP-------LMFRSDAYHPDHFNCTHCGKELTAEARE---- 174
Query: 555 PLDGHVLCRKCH 566
L G + C CH
Sbjct: 175 -LKGELYCLPCH 185
Score = 69.3 bits (168), Expect = 9e-12
Identities = 46/166 (27%), Positives = 66/166 (39%), Gaps = 17/166 (10%)
Query: 384 CGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDTLEK 443
CG C + + ++A+ +H CF C C +L F G C C+ K
Sbjct: 71 CGSCGEFIIGR--VIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKAK 128
Query: 444 ------CNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYH 497
C C I ++ L AYHP F C C + L T+ + +C+P +
Sbjct: 129 GLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKEL--TAEARELKGELYCLPCHD 186
Query: 498 KQYAPRCSVCSEPIMPEPGRDETVRVVALDKNFHMKCYKCEDCGKP 543
K P C C PI E V AL K +H++ + C C KP
Sbjct: 187 KMGVPICGACRRPI-------EGRVVNALGKQWHVEHFVCAKCEKP 225
Score = 64.3 bits (155), Expect = 3e-10
Identities = 35/117 (29%), Positives = 53/117 (45%), Gaps = 3/117 (2%)
Query: 383 LCGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDTL- 441
+CG C +P+ V ALG+ +H+ F C +C + G + Y +G YCE Y
Sbjct: 192 ICGACRRPIEGR--VVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFG 249
Query: 442 EKCNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHK 498
+ C C I ++ A KA+ CF+C C L + V+ +P C Y K
Sbjct: 250 DVCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCYEK 306
>gi|238776786 LIM and senescent cell antigen-like domains 2 isoform
3 [Homo sapiens]
Length = 341
Score = 94.7 bits (234), Expect = 2e-19
Identities = 59/192 (30%), Positives = 85/192 (44%), Gaps = 19/192 (9%)
Query: 381 NELCGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDT 440
N +C RC + A+ V + G+L+H CF C QC + FY EG YCE +
Sbjct: 12 NAVCQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQML 71
Query: 441 LEK-CNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHKQ 499
C +CGE I R+++A +HP CF C +C L F V A R C P ++++
Sbjct: 72 FAPCCGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGF-VKNAGRHLCRPCHNRE 130
Query: 500 YAPR-----CSVCSEPIMPEPGRDETVRVVALDKNFHMKCYKCEDCGKPLSIEADDNGCF 554
A C C I +P ++ +H + C CGK L+ EA +
Sbjct: 131 KAKGLGKYICQRCHLVIDEQP-------LMFRSDAYHPDHFNCTHCGKELTAEARE---- 179
Query: 555 PLDGHVLCRKCH 566
L G + C CH
Sbjct: 180 -LKGELYCLPCH 190
Score = 69.3 bits (168), Expect = 9e-12
Identities = 46/166 (27%), Positives = 66/166 (39%), Gaps = 17/166 (10%)
Query: 384 CGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDTLEK 443
CG C + + ++A+ +H CF C C +L F G C C+ K
Sbjct: 76 CGSCGEFIIGR--VIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKAK 133
Query: 444 ------CNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYH 497
C C I ++ L AYHP F C C + L T+ + +C+P +
Sbjct: 134 GLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKEL--TAEARELKGELYCLPCHD 191
Query: 498 KQYAPRCSVCSEPIMPEPGRDETVRVVALDKNFHMKCYKCEDCGKP 543
K P C C PI E V AL K +H++ + C C KP
Sbjct: 192 KMGVPICGACRRPI-------EGRVVNALGKQWHVEHFVCAKCEKP 230
Score = 64.3 bits (155), Expect = 3e-10
Identities = 35/117 (29%), Positives = 53/117 (45%), Gaps = 3/117 (2%)
Query: 383 LCGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDTL- 441
+CG C +P+ V ALG+ +H+ F C +C + G + Y +G YCE Y
Sbjct: 197 ICGACRRPIEGR--VVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFG 254
Query: 442 EKCNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHK 498
+ C C I ++ A KA+ CF+C C L + V+ +P C Y K
Sbjct: 255 DVCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCYEK 311
>gi|40804748 LIM and senescent cell antigen-like domains 2 isoform 2
[Homo sapiens]
Length = 365
Score = 94.7 bits (234), Expect = 2e-19
Identities = 59/192 (30%), Positives = 85/192 (44%), Gaps = 19/192 (9%)
Query: 381 NELCGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDT 440
N +C RC + A+ V + G+L+H CF C QC + FY EG YCE +
Sbjct: 36 NAVCQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQML 95
Query: 441 LEK-CNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHKQ 499
C +CGE I R+++A +HP CF C +C L F V A R C P ++++
Sbjct: 96 FAPCCGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGF-VKNAGRHLCRPCHNRE 154
Query: 500 YAPR-----CSVCSEPIMPEPGRDETVRVVALDKNFHMKCYKCEDCGKPLSIEADDNGCF 554
A C C I +P ++ +H + C CGK L+ EA +
Sbjct: 155 KAKGLGKYICQRCHLVIDEQP-------LMFRSDAYHPDHFNCTHCGKELTAEARE---- 203
Query: 555 PLDGHVLCRKCH 566
L G + C CH
Sbjct: 204 -LKGELYCLPCH 214
Score = 69.3 bits (168), Expect = 9e-12
Identities = 46/166 (27%), Positives = 66/166 (39%), Gaps = 17/166 (10%)
Query: 384 CGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDTLEK 443
CG C + + ++A+ +H CF C C +L F G C C+ K
Sbjct: 100 CGSCGEFIIGR--VIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKAK 157
Query: 444 ------CNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYH 497
C C I ++ L AYHP F C C + L T+ + +C+P +
Sbjct: 158 GLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKEL--TAEARELKGELYCLPCHD 215
Query: 498 KQYAPRCSVCSEPIMPEPGRDETVRVVALDKNFHMKCYKCEDCGKP 543
K P C C PI E V AL K +H++ + C C KP
Sbjct: 216 KMGVPICGACRRPI-------EGRVVNALGKQWHVEHFVCAKCEKP 254
Score = 64.3 bits (155), Expect = 3e-10
Identities = 35/117 (29%), Positives = 53/117 (45%), Gaps = 3/117 (2%)
Query: 383 LCGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDTL- 441
+CG C +P+ V ALG+ +H+ F C +C + G + Y +G YCE Y
Sbjct: 221 ICGACRRPIEGR--VVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFG 278
Query: 442 EKCNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHK 498
+ C C I ++ A KA+ CF+C C L + V+ +P C Y K
Sbjct: 279 DVCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCYEK 335
>gi|47132519 Ras association and pleckstrin homology domains 1 isoform
1 [Homo sapiens]
Length = 1250
Score = 94.7 bits (234), Expect = 2e-19
Identities = 102/374 (27%), Positives = 135/374 (36%), Gaps = 34/374 (9%)
Query: 3 APRPSPAISVSVSAPAFYAPQKKFGPVVAPKPKVNPFRPGDSEPPPAPGAQRAQMGRVGE 62
A + S A+ + P + K +V P V P P PPP PG+ AQ+
Sbjct: 676 ASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPP--PPPPPPPPTPGSAMAQLKPAPC 733
Query: 63 IPPPPPEDFPLPPPPLAGDGDDAEGALGGAFPPPPPPIEESFPPAPLEEEIFPSPPP--- 119
P P F PPPPL + PPPPPPI PP + + P P
Sbjct: 734 APSLP--QFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQAPPKPLVTIPAPTST 791
Query: 120 ----PPEEEGGPEAPIPPPPQPREKVSSIDLEIDSLSSLLDDMTKNDPFKARVSSGYVPP 175
P + P P PP P P +K + S + P + S P
Sbjct: 792 KTVAPVVTQAAPPTPTPPVP-PAKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFCAKP 850
Query: 176 PVATPFSSKSSTKPAAGGTAPLPPWKSPSSSQPLPQVPAPAQSQTQFHVQPQPQPKPQVQ 235
P +P S S P PP SQPL VPA Q+ V+ +P+ +P
Sbjct: 851 P-PSPLSPVPSVVKQIASQFPPPPTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQPSSI 909
Query: 236 LHVQSQTQPVSLANTQPRGPPASSPAPAPKFSPVTPKFTPVASKF-SPG-------APGG 287
P ++ PP SP PAP P P +P K SPG +PGG
Sbjct: 910 PVPSPDFPPPPPESSLVFPPPPPSPVPAPP-PPPPPTASPTPDKSGSPGKKTSKTSSPGG 968
Query: 288 SGSQPNQKLGHPEALSAGTGSPQP--PSFTYAQQREKPRVQE---KQHPVPPPAQNQNQV 342
P + S+G P+P PS + P + + +PPPA
Sbjct: 969 KKPPPTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPA------ 1022
Query: 343 RSPGAPGPLTLKEV 356
+P PG L L V
Sbjct: 1023 -APPKPGKLNLSGV 1035
Score = 92.4 bits (228), Expect = 1e-18
Identities = 100/380 (26%), Positives = 131/380 (34%), Gaps = 95/380 (25%)
Query: 22 PQKKFGPVVAPKPK-VNPF---RPGDSEPPPAPGAQRAQMGRVGEIPPPPPEDFPLPPPP 77
P P ++P+PK V P+ +P PPP P PPPPP P PPPP
Sbjct: 601 PYTSLVPPLSPQPKIVTPYTASQPSPPLPPPPPP------------PPPPPPPPPPPPPP 648
Query: 78 LAGDGDDAEGAL--------------------GGAFPPPPPPIEESFPPAPLEEEIFPSP 117
L + G+ G F PP PP+ +S + + P
Sbjct: 649 LPSQSAPSAGSAAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQS-------QSVKPQI 701
Query: 118 PPPPEEEGGPEAPIPPPPQPREKVSSIDLEIDSLSSLLDDMTKNDPFKARVSSGYVPPPV 177
PP P P PPPP P ++ + K P + PPP
Sbjct: 702 LVPPNGVVPPPPPPPPPPTPGSAMAQL---------------KPAPCAPSLPQFSAPPPP 746
Query: 178 ATPFSSKSSTKPAAGGTAPLPPWKSPSSSQ----PLPQVPAPAQSQTQFHVQPQ---PQP 230
+ T+ A P PP +P Q PL +PAP ++T V Q P P
Sbjct: 747 LKIHQVQHITQVAPPTPPPPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTP 806
Query: 231 KPQVQLHVQSQTQPVSLANTQPRGPPASSPAPA-PK------------FSPVTPKFTPVA 277
P V + P S P PP P P PK SPV +A
Sbjct: 807 TPPVPPAKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIA 866
Query: 278 SKF-SPGAPGGSGSQPNQKLGHPEALSAGTGSPQPPSFTYAQQREKPRVQEKQHPV---- 332
S+F P P SQP + + A PP+ + KP+ Q PV
Sbjct: 867 SQFPPPPTPPAMESQP------LKPVPANVAPQSPPAV-----KAKPKWQPSSIPVPSPD 915
Query: 333 -PPPAQNQNQVRSPGAPGPL 351
PPP + V P P P+
Sbjct: 916 FPPPPPESSLVFPPPPPSPV 935
Score = 68.6 bits (166), Expect = 2e-11
Identities = 99/413 (23%), Positives = 138/413 (33%), Gaps = 88/413 (21%)
Query: 2 AAPRPSPAISVSVSAPAFYA----PQKKFGPVVAPKPKVNPFRPGDSEPPPAPGAQRAQM 57
A P P+P + + PAF A P PV P P + + ++PPP+P + +
Sbjct: 802 APPTPTPPVPPAKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSV 861
Query: 58 GR--VGEIPPPPP----EDFPLPPPP--LAGDGDDAEGAL-----------GGAFPPPPP 98
+ + PPPP E PL P P +A A A FPPPPP
Sbjct: 862 VKQIASQFPPPPTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPP 921
Query: 99 PIEESFPPAPLEEEIFPSPPPP------PEEEGGPEAPI-----------PPPPQPREKV 141
FPP P P PPPP P++ G P PP PQ +
Sbjct: 922 ESSLVFPPPPPSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSI 981
Query: 142 SSI------DLEIDSLSSLLDDMTKNDPFKARVSSGYVPPPVATPFSSK----------- 184
S + + S+ SL+ T S +PPP A P K
Sbjct: 982 KSSSGAEHPEPKRPSVDSLVSKFTP-PAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGV 1040
Query: 185 ------SSTKPAAGGTA-------PLPPWKS------PSSSQPLP--QVPAPAQSQTQFH 223
S+ P G P PP S P + PLP ++PA T
Sbjct: 1041 LQQGCVSAKAPVLSGRGKDSVVEFPSPPSDSDFPPPPPETELPLPPIEIPAVFSGNTSPK 1100
Query: 224 VQ-PQPQPKPQVQLHVQSQTQPVSLANTQPRGPPASSPAPAPKFSPVTPKFTPVASKFSP 282
V PQP+ ++ V+ P + + P + V P+ P + K S
Sbjct: 1101 VAVVNPQPQQWSKMSVKKAPPPTRPKRNDSTRLTQAEISEQPTMATVVPQ-VPTSPKSSL 1159
Query: 283 GAPGGSGSQPNQKLGHPEALSAGTGSPQPPSFTYAQQREKPRVQEKQHPVPPP 335
G + N+ L G S + R +P +PPP
Sbjct: 1160 SVQPGFLADLNRTLQRKSITRHG-------SLSSRMSRAEPTATMDDMALPPP 1205
Score = 42.4 bits (98), Expect = 0.001
Identities = 51/214 (23%), Positives = 74/214 (34%), Gaps = 11/214 (5%)
Query: 141 VSSIDLEIDSLSSLLDDMTK------NDPFKARVSSGYVPPPVATPFSSKSSTKPAAGGT 194
VSS+ E + L++ +K N P+ + V P + TP+++ + P
Sbjct: 573 VSSVFSEAWKRGTQLEESSKARMESMNRPYTSLVPPLSPQPKIVTPYTASQPSPPLPPPP 632
Query: 195 APLPPWKSPSSSQPLPQVPAPAQSQTQFHVQPQPQPKPQVQLHVQSQTQPVSLANTQPRG 254
P PP P P P P P+QS K +Q+ +Q P
Sbjct: 633 PPPPP---PPPPPPPPPPPLPSQSAPSAGSAAPMFVKYSTITRLQNASQHSGALFKPPTP 689
Query: 255 PPASSPAPAPKFSPVTPKFTPVASKFSPGAPGGSGSQPNQKLGHPEALSAGTGSPQPPSF 314
P S + P+ + P V P P GS Q P A S S PP
Sbjct: 690 PVMQSQSVKPQI--LVPPNGVVPPPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPL 747
Query: 315 TYAQQREKPRVQEKQHPVPPPAQNQNQVRSPGAP 348
Q + +V P PPP ++P P
Sbjct: 748 KIHQVQHITQVAPPTPPPPPPIPAPLPPQAPPKP 781
>gi|221316659 leupaxin isoform 1 [Homo sapiens]
Length = 391
Score = 94.0 bits (232), Expect = 3e-19
Identities = 50/180 (27%), Positives = 80/180 (44%), Gaps = 15/180 (8%)
Query: 384 CGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDTLE- 442
C C +P+A + ALGQ +H F C C +++ F+ G YC Y
Sbjct: 157 CASCQKPIAGK--VIHALGQSWHPEHFVCTHCKEEIGSSPFFERSGLAYCPNDYHQLFSP 214
Query: 443 KCNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHKQYAP 502
+C C PI D++L A + +HP F C C + G ++ +P+C D+ ++P
Sbjct: 215 RCAYCAAPILDKVLTAMNQTWHPEHFFCSHCGE-VFGAEGFHEKDKKPYCRKDFLAMFSP 273
Query: 503 RCSVCSEPIMPEPGRDETVRVVALDKNFHMKCYKCEDCGKPLSIEADDNGCFPLDGHVLC 562
+C C+ P++ + A+D +H +C+ C DC S F LDG C
Sbjct: 274 KCGGCNRPVLEN-------YLSAMDTVWHPECFVCGDCFTSFS----TGSFFELDGRPFC 322
Score = 73.6 bits (179), Expect = 5e-13
Identities = 39/120 (32%), Positives = 61/120 (50%), Gaps = 8/120 (6%)
Query: 384 CGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCY---TDT 440
CG C++P+ + + A+ ++H CF C C F+ L+G P+CE Y T
Sbjct: 275 CGGCNRPVL--ENYLSAMDTVWHPECFVCGDCFTSFSTGSFFELDGRPFCELHYHHRRGT 332
Query: 441 LEKCNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHKQY 500
L C+ CG+PIT R + A G +HP F C C L F +Q ++ +C P ++K +
Sbjct: 333 L--CHGCGQPITGRCISAMGYKFHPEHFVCAFCLTQLSKGIF-REQNDKTYCQPCFNKLF 389
Score = 72.0 bits (175), Expect = 1e-12
Identities = 45/163 (27%), Positives = 64/163 (39%), Gaps = 11/163 (6%)
Query: 384 CGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDTLE- 442
C C P+ + A+ Q +H F C C + + F+ + PYC +
Sbjct: 216 CAYCAAPIL--DKVLTAMNQTWHPEHFFCSHCGEVFGAEGFHEKDKKPYCRKDFLAMFSP 273
Query: 443 KCNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHKQYAP 502
KC C P+ + L A +HP CF C C SF + RP C YH +
Sbjct: 274 KCGGCNRPVLENYLSAMDTVWHPECFVCGDCFTSFSTGSFF-ELDGRPFCELHYHHRRGT 332
Query: 503 RCSVCSEPIMPEPGRDETVRVVALDKNFHMKCYKCEDCGKPLS 545
C C +PI GR + A+ FH + + C C LS
Sbjct: 333 LCHGCGQPI---TGR----CISAMGYKFHPEHFVCAFCLTQLS 368
Score = 70.1 bits (170), Expect = 5e-12
Identities = 34/121 (28%), Positives = 63/121 (52%), Gaps = 12/121 (9%)
Query: 444 CNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHKQYAPR 503
C +C +PI +++ A G+++HP F C C + G+S +++ +C DYH+ ++PR
Sbjct: 157 CASCQKPIAGKVIHALGQSWHPEHFVCTHCKEEI-GSSPFFERSGLAYCPNDYHQLFSPR 215
Query: 504 CSVCSEPIMPEPGRDETVRVVALDKNFHMKCYKCEDCGKPLSIEADDNGCFPLDGHVLCR 563
C+ C+ PI+ + + A+++ +H + + C CG+ E G D CR
Sbjct: 216 CAYCAAPILDKV-------LTAMNQTWHPEHFFCSHCGEVFGAE----GFHEKDKKPYCR 264
Query: 564 K 564
K
Sbjct: 265 K 265
>gi|4758670 leupaxin isoform 2 [Homo sapiens]
Length = 386
Score = 94.0 bits (232), Expect = 3e-19
Identities = 50/180 (27%), Positives = 80/180 (44%), Gaps = 15/180 (8%)
Query: 384 CGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDTLE- 442
C C +P+A + ALGQ +H F C C +++ F+ G YC Y
Sbjct: 152 CASCQKPIAGK--VIHALGQSWHPEHFVCTHCKEEIGSSPFFERSGLAYCPNDYHQLFSP 209
Query: 443 KCNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHKQYAP 502
+C C PI D++L A + +HP F C C + G ++ +P+C D+ ++P
Sbjct: 210 RCAYCAAPILDKVLTAMNQTWHPEHFFCSHCGE-VFGAEGFHEKDKKPYCRKDFLAMFSP 268
Query: 503 RCSVCSEPIMPEPGRDETVRVVALDKNFHMKCYKCEDCGKPLSIEADDNGCFPLDGHVLC 562
+C C+ P++ + A+D +H +C+ C DC S F LDG C
Sbjct: 269 KCGGCNRPVLEN-------YLSAMDTVWHPECFVCGDCFTSFS----TGSFFELDGRPFC 317
Score = 73.6 bits (179), Expect = 5e-13
Identities = 39/120 (32%), Positives = 61/120 (50%), Gaps = 8/120 (6%)
Query: 384 CGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCY---TDT 440
CG C++P+ + + A+ ++H CF C C F+ L+G P+CE Y T
Sbjct: 270 CGGCNRPVL--ENYLSAMDTVWHPECFVCGDCFTSFSTGSFFELDGRPFCELHYHHRRGT 327
Query: 441 LEKCNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHKQY 500
L C+ CG+PIT R + A G +HP F C C L F +Q ++ +C P ++K +
Sbjct: 328 L--CHGCGQPITGRCISAMGYKFHPEHFVCAFCLTQLSKGIF-REQNDKTYCQPCFNKLF 384
Score = 72.0 bits (175), Expect = 1e-12
Identities = 45/163 (27%), Positives = 64/163 (39%), Gaps = 11/163 (6%)
Query: 384 CGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDTLE- 442
C C P+ + A+ Q +H F C C + + F+ + PYC +
Sbjct: 211 CAYCAAPIL--DKVLTAMNQTWHPEHFFCSHCGEVFGAEGFHEKDKKPYCRKDFLAMFSP 268
Query: 443 KCNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHKQYAP 502
KC C P+ + L A +HP CF C C SF + RP C YH +
Sbjct: 269 KCGGCNRPVLENYLSAMDTVWHPECFVCGDCFTSFSTGSFF-ELDGRPFCELHYHHRRGT 327
Query: 503 RCSVCSEPIMPEPGRDETVRVVALDKNFHMKCYKCEDCGKPLS 545
C C +PI GR + A+ FH + + C C LS
Sbjct: 328 LCHGCGQPI---TGR----CISAMGYKFHPEHFVCAFCLTQLS 363
Score = 70.1 bits (170), Expect = 5e-12
Identities = 34/121 (28%), Positives = 63/121 (52%), Gaps = 12/121 (9%)
Query: 444 CNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHKQYAPR 503
C +C +PI +++ A G+++HP F C C + G+S +++ +C DYH+ ++PR
Sbjct: 152 CASCQKPIAGKVIHALGQSWHPEHFVCTHCKEEI-GSSPFFERSGLAYCPNDYHQLFSPR 210
Query: 504 CSVCSEPIMPEPGRDETVRVVALDKNFHMKCYKCEDCGKPLSIEADDNGCFPLDGHVLCR 563
C+ C+ PI+ + + A+++ +H + + C CG+ E G D CR
Sbjct: 211 CAYCAAPILDKV-------LTAMNQTWHPEHFFCSHCGEVFGAE----GFHEKDKKPYCR 259
Query: 564 K 564
K
Sbjct: 260 K 260
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.134 0.426
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,634,906
Number of Sequences: 37866
Number of extensions: 3019760
Number of successful extensions: 53768
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 732
Number of HSP's successfully gapped in prelim test: 2146
Number of HSP's that attempted gapping in prelim test: 18964
Number of HSP's gapped (non-prelim): 17062
length of query: 572
length of database: 18,247,518
effective HSP length: 108
effective length of query: 464
effective length of database: 14,157,990
effective search space: 6569307360
effective search space used: 6569307360
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.