Search of human proteins with 4507925

Search of human proteins with 4507925

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4507925 WNT1 inducible signaling pathway protein 3 isoform 1
[Homo sapiens]
         (354 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|38202241 WNT1 inducible signaling pathway protein 3 isoform 3...   774   0.0  
gi|4507925 WNT1 inducible signaling pathway protein 3 isoform 1 ...   774   0.0  
gi|4507921 WNT1 inducible signaling pathway protein 1 isoform 1 ...   329   3e-90
gi|4503123 connective tissue growth factor [Homo sapiens]             273   1e-73
gi|31542331 cysteine-rich, angiogenic inducer, 61 [Homo sapiens]      229   3e-60
gi|4505423 nephroblastoma overexpressed precursor [Homo sapiens]      224   9e-59
gi|18491000 WNT1 inducible signaling pathway protein 1 isoform 2...   161   9e-40
gi|4507923 WNT1 inducible signaling pathway protein 2 precursor ...   132   4e-31
gi|89191868 von Willebrand factor preproprotein [Homo sapiens]         45   8e-05
gi|10092639 cysteine-rich motor neuron 1 [Homo sapiens]                42   6e-04
gi|114431244 von Willebrand factor C and EGF domains [Homo sapiens]    40   0.002
gi|4506141 HtrA serine peptidase 1 precursor [Homo sapiens]            40   0.004
gi|22129776 HtrA serine peptidase 3 [Homo sapiens]                     39   0.005
gi|112789555 ADAM metallopeptidase with thrombospondin type 1 mo...    39   0.005
gi|40317626 thrombospondin 1 precursor [Homo sapiens]                  39   0.007
gi|4504619 insulin-like growth factor binding protein 7 [Homo sa...    38   0.012
gi|209571519 cysteine rich BMP regulator 2 isoform 1 [Homo sapiens]    37   0.021
gi|134031945 SCO-spondin [Homo sapiens]                                37   0.021
gi|55925576 insulin-like growth factor binding protein 2, 36kDa ...    37   0.027
gi|209571521 cysteine rich BMP regulator 2 isoform 2 [Homo sapiens]    37   0.027
gi|150170672 thrombospondin, type I, domain containing 7A [Homo ...    37   0.027
gi|110347423 spondin 1, extracellular matrix protein [Homo sapiens]    37   0.035
gi|24308541 HtrA serine peptidase 4 precursor [Homo sapiens]           37   0.035
gi|50845384 ADAM metallopeptidase with thrombospondin type 1 mot...    36   0.046
gi|5901946 endothelial cell-specific molecule 1 isoform a precur...    35   0.078
gi|208022668 endothelial cell-specific molecule 1 isoform b prec...    35   0.078
gi|56090548 insulin-like growth factor binding protein-like 1 [H...    35   0.078
gi|4759146 slit homolog 2 [Homo sapiens]                               35   0.13 
gi|188528675 slit homolog 1 [Homo sapiens]                             34   0.17 
gi|37693519 BMP-binding endothelial regulator precursor protein ...    34   0.17 

>gi|38202241 WNT1 inducible signaling pathway protein 3 isoform 3
           [Homo sapiens]
          Length = 372

 Score =  774 bits (1998), Expect = 0.0
 Identities = 354/354 (100%), Positives = 354/354 (100%)

Query: 1   MQGLLFSTLLLAGLAQFCCRVQGTGPLDTTPEGRPGEVSDAPQRKQFCHWPCKCPQQKPR 60
           MQGLLFSTLLLAGLAQFCCRVQGTGPLDTTPEGRPGEVSDAPQRKQFCHWPCKCPQQKPR
Sbjct: 19  MQGLLFSTLLLAGLAQFCCRVQGTGPLDTTPEGRPGEVSDAPQRKQFCHWPCKCPQQKPR 78

Query: 61  CPPGVSLVRDGCGCCKICAKQPGEICNEADLCDPHKGLYCDYSVDRPRYETGVCAYLVAV 120
           CPPGVSLVRDGCGCCKICAKQPGEICNEADLCDPHKGLYCDYSVDRPRYETGVCAYLVAV
Sbjct: 79  CPPGVSLVRDGCGCCKICAKQPGEICNEADLCDPHKGLYCDYSVDRPRYETGVCAYLVAV 138

Query: 121 GCEFNQVHYHNGQVFQPNPLFSCLCVSGAIGCTPLFIPKLAGSHCSGAKGGKKSDQSNCS 180
           GCEFNQVHYHNGQVFQPNPLFSCLCVSGAIGCTPLFIPKLAGSHCSGAKGGKKSDQSNCS
Sbjct: 139 GCEFNQVHYHNGQVFQPNPLFSCLCVSGAIGCTPLFIPKLAGSHCSGAKGGKKSDQSNCS 198

Query: 181 LEPLLQQLSTSYKTMPAYRNLPLIWKKKCLVQATKWTPCSRTCGMGISNRVTNENSNCEM 240
           LEPLLQQLSTSYKTMPAYRNLPLIWKKKCLVQATKWTPCSRTCGMGISNRVTNENSNCEM
Sbjct: 199 LEPLLQQLSTSYKTMPAYRNLPLIWKKKCLVQATKWTPCSRTCGMGISNRVTNENSNCEM 258

Query: 241 RKEKRLCYIQPCDSNILKTIKIPKGKTCQPTFQLSKAEKFVFSGCSSTQSYKPTFCGICL 300
           RKEKRLCYIQPCDSNILKTIKIPKGKTCQPTFQLSKAEKFVFSGCSSTQSYKPTFCGICL
Sbjct: 259 RKEKRLCYIQPCDSNILKTIKIPKGKTCQPTFQLSKAEKFVFSGCSSTQSYKPTFCGICL 318

Query: 301 DKRCCIPNKSKMITIQFDCPNEGSFKWKMLWITSCVCQRNCREPGDIFSELKIL 354
           DKRCCIPNKSKMITIQFDCPNEGSFKWKMLWITSCVCQRNCREPGDIFSELKIL
Sbjct: 319 DKRCCIPNKSKMITIQFDCPNEGSFKWKMLWITSCVCQRNCREPGDIFSELKIL 372


>gi|4507925 WNT1 inducible signaling pathway protein 3 isoform 1
           [Homo sapiens]
          Length = 354

 Score =  774 bits (1998), Expect = 0.0
 Identities = 354/354 (100%), Positives = 354/354 (100%)

Query: 1   MQGLLFSTLLLAGLAQFCCRVQGTGPLDTTPEGRPGEVSDAPQRKQFCHWPCKCPQQKPR 60
           MQGLLFSTLLLAGLAQFCCRVQGTGPLDTTPEGRPGEVSDAPQRKQFCHWPCKCPQQKPR
Sbjct: 1   MQGLLFSTLLLAGLAQFCCRVQGTGPLDTTPEGRPGEVSDAPQRKQFCHWPCKCPQQKPR 60

Query: 61  CPPGVSLVRDGCGCCKICAKQPGEICNEADLCDPHKGLYCDYSVDRPRYETGVCAYLVAV 120
           CPPGVSLVRDGCGCCKICAKQPGEICNEADLCDPHKGLYCDYSVDRPRYETGVCAYLVAV
Sbjct: 61  CPPGVSLVRDGCGCCKICAKQPGEICNEADLCDPHKGLYCDYSVDRPRYETGVCAYLVAV 120

Query: 121 GCEFNQVHYHNGQVFQPNPLFSCLCVSGAIGCTPLFIPKLAGSHCSGAKGGKKSDQSNCS 180
           GCEFNQVHYHNGQVFQPNPLFSCLCVSGAIGCTPLFIPKLAGSHCSGAKGGKKSDQSNCS
Sbjct: 121 GCEFNQVHYHNGQVFQPNPLFSCLCVSGAIGCTPLFIPKLAGSHCSGAKGGKKSDQSNCS 180

Query: 181 LEPLLQQLSTSYKTMPAYRNLPLIWKKKCLVQATKWTPCSRTCGMGISNRVTNENSNCEM 240
           LEPLLQQLSTSYKTMPAYRNLPLIWKKKCLVQATKWTPCSRTCGMGISNRVTNENSNCEM
Sbjct: 181 LEPLLQQLSTSYKTMPAYRNLPLIWKKKCLVQATKWTPCSRTCGMGISNRVTNENSNCEM 240

Query: 241 RKEKRLCYIQPCDSNILKTIKIPKGKTCQPTFQLSKAEKFVFSGCSSTQSYKPTFCGICL 300
           RKEKRLCYIQPCDSNILKTIKIPKGKTCQPTFQLSKAEKFVFSGCSSTQSYKPTFCGICL
Sbjct: 241 RKEKRLCYIQPCDSNILKTIKIPKGKTCQPTFQLSKAEKFVFSGCSSTQSYKPTFCGICL 300

Query: 301 DKRCCIPNKSKMITIQFDCPNEGSFKWKMLWITSCVCQRNCREPGDIFSELKIL 354
           DKRCCIPNKSKMITIQFDCPNEGSFKWKMLWITSCVCQRNCREPGDIFSELKIL
Sbjct: 301 DKRCCIPNKSKMITIQFDCPNEGSFKWKMLWITSCVCQRNCREPGDIFSELKIL 354


>gi|4507921 WNT1 inducible signaling pathway protein 1 isoform 1
           precursor [Homo sapiens]
          Length = 367

 Score =  329 bits (843), Expect = 3e-90
 Identities = 150/334 (44%), Positives = 207/334 (61%), Gaps = 10/334 (2%)

Query: 26  PLDTTPEGRPGEVSDAPQRKQFCHWPCKCPQQKPRCPPGVSLVRDGCGCCKICAKQPGEI 85
           P  TT +  P  + D   R QFC WPC+CP   PRCP GVSL+ DGC CCK+CA+Q G+ 
Sbjct: 27  PAPTTMDFTPAPLEDTSSRPQFCKWPCECPPSPPRCPLGVSLITDGCECCKMCAQQLGDN 86

Query: 86  CNEADLCDPHKGLYCDYSVDRPRYETGVCAYLVAVGCEFNQVHYHNGQVFQPNPLFSCLC 145
           C EA +CDPH+GLYCDYS DRPRY  GVCA +V VGC  + V Y+NGQ FQPN  ++C C
Sbjct: 87  CTEAAICDPHRGLYCDYSGDRPRYAIGVCAQVVGVGCVLDGVRYNNGQSFQPNCKYNCTC 146

Query: 146 VSGAIGCTPLFI----PKLAGSHCSGAK-GGKKSDQSNCSLEPLLQQLSTSYKTMPAYRN 200
           + GA+GCTPL +    P+L   H       G   +Q  C  +   +   T+ +   A+  
Sbjct: 147 IDGAVGCTPLCLRVRPPRLWCPHPRRVSIPGHCCEQWVCE-DDAKRPRKTAPRDTGAFDA 205

Query: 201 LPLI--WKKKCLVQATKWTPCSRTCGMGISNRVTNENSNCEMRKEKRLCYIQPCDSNILK 258
           +  +  W + C+   + W+PCS +CG+G+S R++N N+ C   +E RLC ++PCD +I  
Sbjct: 206 VGEVEAWHRNCIAYTSPWSPCSTSCGLGVSTRISNVNAQCWPEQESRLCNLRPCDVDIHT 265

Query: 259 TIKIPKGKTCQPTFQLSKAEKFVFSGCSSTQSYKPTFCGICLDKRCCIPNKSKMITIQFD 318
            IK   GK C   +Q   +  F  +GC ST+SY+P +CG+C+D RCCIP KSK I + F 
Sbjct: 266 LIK--AGKKCLAVYQPEASMNFTLAGCISTRSYQPKYCGVCMDNRCCIPYKSKTIDVSFQ 323

Query: 319 CPNEGSFKWKMLWITSCVCQRNCREPGDIFSELK 352
           CP+   F  ++LWI +C C  +CR P DIF++L+
Sbjct: 324 CPDGLGFSRQVLWINACFCNLSCRNPNDIFADLE 357


>gi|4503123 connective tissue growth factor [Homo sapiens]
          Length = 349

 Score =  273 bits (699), Expect = 1e-73
 Identities = 133/326 (40%), Positives = 189/326 (57%), Gaps = 25/326 (7%)

Query: 42  PQRKQFCHWPCKCPQQK-PRCPPGVSLVRDGCGCCKICAKQPGEICNEADLCDPHKGLYC 100
           P   Q C  PC+CP +  PRCP GVSLV DGCGCC++CAKQ GE+C E D CDPHKGL+C
Sbjct: 23  PAVGQNCSGPCRCPDEPAPRCPAGVSLVLDGCGCCRVCAKQLGELCTERDPCDPHKGLFC 82

Query: 101 DYSVDRPRYETGVCAYLVAVGCEFNQVHYHNGQVFQPNPLFSCLCVSGAIGCTPLF---- 156
           D+     R + GVC       C F    Y +G+ FQ +  + C C+ GA+GC PL     
Sbjct: 83  DFGSPANR-KIGVCTAKDGAPCIFGGTVYRSGESFQSSCKYQCTCLDGAVGCMPLCSMDV 141

Query: 157 -IP----------KLAGSHCSGAKGGKKSDQSNCSLEPLLQQLSTSYKTMPAYRNLPLIW 205
            +P          KL G  C      +  DQ+      ++     +Y+    +   P + 
Sbjct: 142 RLPSPDCPFPRRVKLPGKCCEEWVCDEPKDQT------VVGPALAAYRLEDTFGPDPTMI 195

Query: 206 KKKCLVQATKWTPCSRTCGMGISNRVTNENSNCEMRKEKRLCYIQPCDSNILKTIKIPKG 265
           +  CLVQ T+W+ CS+TCGMGIS RVTN+N++C + K+ RLC ++PC++++ + IK  KG
Sbjct: 196 RANCLVQTTEWSACSKTCGMGISTRVTNDNASCRLEKQSRLCMVRPCEADLEENIK--KG 253

Query: 266 KTCQPTFQLSKAEKFVFSGCSSTQSYKPTFCGICLDKRCCIPNKSKMITIQFDCPNEGSF 325
           K C  T ++SK  KF  SGC+S ++Y+  FCG+C D RCC P+++  + ++F CP+    
Sbjct: 254 KKCIRTPKISKPIKFELSGCTSMKTYRAKFCGVCTDGRCCTPHRTTTLPVEFKCPDGEVM 313

Query: 326 KWKMLWITSCVCQRNCREPGDIFSEL 351
           K  M++I +C C  NC    DIF  L
Sbjct: 314 KKNMMFIKTCACHYNCPGDNDIFESL 339


>gi|31542331 cysteine-rich, angiogenic inducer, 61 [Homo sapiens]
          Length = 381

 Score =  229 bits (584), Expect = 3e-60
 Identities = 121/337 (35%), Positives = 171/337 (50%), Gaps = 46/337 (13%)

Query: 48  CHWPCKCPQQKPRCPPGVSLVRDGCGCCKICAKQPGEICNEADLCDPHKGLYCDYSVDRP 107
           C   C CP + P+C PGV LVRDGCGCCK+CAKQ  E C++   CD  KGL C++     
Sbjct: 26  CPAACHCPLEAPKCAPGVGLVRDGCGCCKVCAKQLNEDCSKTQPCDHTKGLECNFGASST 85

Query: 108 RYETGVC-AYLVAVGCEFNQVHYHNGQVFQPNPLFSCLCVSGAIGCTPLF---------- 156
             + G+C A      CE+N   Y NG+ FQPN    C C+ GA+GC PL           
Sbjct: 86  ALK-GICRAQSEGRPCEYNSRIYQNGESFQPNCKHQCTCIDGAVGCIPLCPQELSLPNLG 144

Query: 157 -----IPKLAGSHCS-----------------GAKGGKKS-DQSNCSL----EPLLQQLS 189
                + K+ G  C                  G  G +   D S   L    E +     
Sbjct: 145 CPNPRLVKVTGQCCEEWVCDEDSIKDPMEDQDGLLGKELGFDASEVELTRNNELIAVGKG 204

Query: 190 TSYKTMPAYRNLPLIWK-----KKCLVQATKWTPCSRTCGMGISNRVTNENSNCEMRKEK 244
           +S K +P +   P I       +KC+VQ T W+ CS+TCG GIS RVTN+N  C + KE 
Sbjct: 205 SSLKRLPVFGMEPRILYNPLQGQKCIVQTTSWSQCSKTCGTGISTRVTNDNPECRLVKET 264

Query: 245 RLCYIQPCDSNILKTIKIPKGKTCQPTFQLSKAEKFVFSGCSSTQSYKPTFCGICLDKRC 304
           R+C ++PC   +  ++K  KGK C  T +  +  +F ++GC S + Y+P +CG C+D RC
Sbjct: 265 RICEVRPCGQPVYSSLK--KGKKCSKTKKSPEPVRFTYAGCLSVKKYRPKYCGSCVDGRC 322

Query: 305 CIPNKSKMITIQFDCPNEGSFKWKMLWITSCVCQRNC 341
           C P  ++ + ++F C +  +F   ++ I SC C  NC
Sbjct: 323 CTPQLTRTVKMRFRCEDGETFSKNVMMIQSCKCNYNC 359


>gi|4505423 nephroblastoma overexpressed precursor [Homo sapiens]
          Length = 357

 Score =  224 bits (571), Expect = 9e-59
 Identities = 117/313 (37%), Positives = 165/313 (52%), Gaps = 23/313 (7%)

Query: 51  PCKCPQQKPRCPPGVSLVRDGCGCCKICAKQPGEICNEADLCDPHKGLYCDYSVDRPRYE 110
           P +CP   P C PGV  V DGC CC +CA+Q GE C++ + CD   GLYCD S D P  +
Sbjct: 40  PGRCPATPPTCAPGVRAVLDGCSCCLVCARQRGESCSDLEPCDESSGLYCDRSAD-PSNQ 98

Query: 111 TGVCAYLVAVGCEFNQVHYHNGQVFQPNPLFSCLCVSGAIGCTP-----LFIPKLAGSHC 165
           TG+C  +    C F+ V Y +G+ FQP+  F C C  G IGC P     + +P+    +C
Sbjct: 99  TGICTAVEGDNCVFDGVIYRSGEKFQPSCKFQCTCRDGQIGCVPRCQLDVLLPE---PNC 155

Query: 166 SGAK----GGKKSDQSNCSLEPLLQQLSTSYKTMPAYRNLPLIWKK------KCLVQATK 215
              +     G+  ++  C  +   ++ S    T+ AYR    +  +       C+ Q T+
Sbjct: 156 PAPRKVEVPGECCEKWICGPD---EEDSLGGLTLAAYRPEATLGVEVSDSSVNCIEQTTE 212

Query: 216 WTPCSRTCGMGISNRVTNENSNCEMRKEKRLCYIQPCDSNILKTIKIPKGKTCQPTFQLS 275
           WT CS++CGMG S RVTN N  CEM K+ RLC ++PC+    +     KGK C  T +  
Sbjct: 213 WTACSKSCGMGFSTRVTNRNRQCEMLKQTRLCMVRPCEQEPEQPTD-KKGKKCLRTKKSL 271

Query: 276 KAEKFVFSGCSSTQSYKPTFCGICLDKRCCIPNKSKMITIQFDCPNEGSFKWKMLWITSC 335
           KA    F  C+S  +YKP FCG+C D RCC P+ +K I  +F C      K  ++ I +C
Sbjct: 272 KAIHLQFKNCTSLHTYKPRFCGVCSDGRCCTPHNTKTIQAEFQCSPGQIVKKPVMVIGTC 331

Query: 336 VCQRNCREPGDIF 348
            C  NC +  + F
Sbjct: 332 TCHTNCPKNNEAF 344


>gi|18491000 WNT1 inducible signaling pathway protein 1 isoform 2
           precursor [Homo sapiens]
          Length = 280

 Score =  161 bits (407), Expect = 9e-40
 Identities = 65/148 (43%), Positives = 96/148 (64%), Gaps = 2/148 (1%)

Query: 205 WKKKCLVQATKWTPCSRTCGMGISNRVTNENSNCEMRKEKRLCYIQPCDSNILKTIKIPK 264
           W + C+   + W+PCS +CG+G+S R++N N+ C   +E RLC ++PCD +I   IK   
Sbjct: 125 WHRNCIAYTSPWSPCSTSCGLGVSTRISNVNAQCWPEQESRLCNLRPCDVDIHTLIKA-- 182

Query: 265 GKTCQPTFQLSKAEKFVFSGCSSTQSYKPTFCGICLDKRCCIPNKSKMITIQFDCPNEGS 324
           GK C   +Q   +  F  +GC ST+SY+P +CG+C+D RCCIP KSK I + F CP+   
Sbjct: 183 GKKCLAVYQPEASMNFTLAGCISTRSYQPKYCGVCMDNRCCIPYKSKTIDVSFQCPDGLG 242

Query: 325 FKWKMLWITSCVCQRNCREPGDIFSELK 352
           F  ++LWI +C C  +CR P DIF++L+
Sbjct: 243 FSRQVLWINACFCNLSCRNPNDIFADLE 270



 Score =  136 bits (343), Expect = 2e-32
 Identities = 56/93 (60%), Positives = 66/93 (70%)

Query: 26  PLDTTPEGRPGEVSDAPQRKQFCHWPCKCPQQKPRCPPGVSLVRDGCGCCKICAKQPGEI 85
           P  TT +  P  + D   R QFC WPC+CP   PRCP GVSL+ DGC CCK+CA+Q G+ 
Sbjct: 27  PAPTTMDFTPAPLEDTSSRPQFCKWPCECPPSPPRCPLGVSLITDGCECCKMCAQQLGDN 86

Query: 86  CNEADLCDPHKGLYCDYSVDRPRYETGVCAYLV 118
           C EA +CDPH+GLYCDYS DRPRY  GVCA+ V
Sbjct: 87  CTEAAICDPHRGLYCDYSGDRPRYAIGVCAHAV 119


>gi|4507923 WNT1 inducible signaling pathway protein 2 precursor
           [Homo sapiens]
          Length = 250

 Score =  132 bits (333), Expect = 4e-31
 Identities = 78/227 (34%), Positives = 107/227 (47%), Gaps = 29/227 (12%)

Query: 44  RKQFCHWPCKCPQQKPRCPPGVSLVRDGCGCCKICAKQPGEICNEADLCDPHKGLYCDYS 103
           R Q C  PC CP   PRCP GV LV DGCGCC++CA++ GE C++  +CD  +GL C   
Sbjct: 22  RTQLCPTPCTCPWPPPRCPLGVPLVLDGCGCCRVCARRLGEPCDQLHVCDASQGLVCQPG 81

Query: 104 VDRPRYETGVCAYLVA---VGCEFNQVHYHNGQVFQPNPLFSCLCVSGAIGCTPLF---- 156
              P     +C  L+A     CE N   Y  G+ FQP+    C C  G   C PL     
Sbjct: 82  AG-PGGRGALC--LLAEDDSSCEVNGRLYREGETFQPHCSIRCRCEDGGFTCVPLCSEDV 138

Query: 157 -IP----------KLAGSHCSGAKGGKKSDQSNCSLEPLLQQLSTSYKTMPAYRNLPLIW 205
            +P          ++ G  C     G+        L     Q S    ++P    +P   
Sbjct: 139 RLPSWDCPHPRRVEVLGKCCPEWVCGQGGGLGTQPLPAQGPQFSGLVSSLPP--GVP--- 193

Query: 206 KKKCLVQATKWTPCSRTCGMGISNRVTNENSNCEMRKEKRLCYIQPC 252
              C   +T W PCS TCG+G++ RV+N+N  C +  ++RLC  +PC
Sbjct: 194 ---CPEWSTAWGPCSTTCGLGMATRVSNQNRFCRLETQRRLCLSRPC 237


>gi|89191868 von Willebrand factor preproprotein [Homo sapiens]
          Length = 2813

 Score = 45.4 bits (106), Expect = 8e-05
 Identities = 36/109 (33%), Positives = 45/109 (41%), Gaps = 27/109 (24%)

Query: 61  CPPGVSLVRDGCGCCKICAK--QPGEICNEADL----CDPHKGLYCDYSVDRPRYETGVC 114
           CP G   ++ G  C   C     P E CNEA L    C P  GLY D        E G C
Sbjct: 652 CPKGQVYLQCGTPCNLTCRSLSYPDEECNEACLEGCFCPP--GLYMD--------ERGDC 701

Query: 115 AYLVAVGCEFNQVHYHNGQVFQPNPLFS-----CLCVSGAIGCTPLFIP 158
                  C      Y++G++FQP  +FS     C C  G + CT   +P
Sbjct: 702 VPKAQCPC------YYDGEIFQPEDIFSDHHTMCYCEDGFMHCTMSGVP 744



 Score = 32.3 bits (72), Expect = 0.66
 Identities = 28/77 (36%), Positives = 36/77 (46%), Gaps = 10/77 (12%)

Query: 52  CKCPQQKPRCPPGVSLVRDGCGCCKICAKQPGEICNEADLCDPHKGLYCDYSVDRP---R 108
           C C     R PPG SL RD C  C IC +    IC+  +   P + L    S  +    R
Sbjct: 348 CPCVHSGKRYPPGTSLSRD-CNTC-IC-RNSQWICSNEEC--PGECLVTGQSHFKSFDNR 402

Query: 109 YET--GVCAYLVAVGCE 123
           Y T  G+C YL+A  C+
Sbjct: 403 YFTFSGICQYLLARDCQ 419


>gi|10092639 cysteine-rich motor neuron 1 [Homo sapiens]
          Length = 1036

 Score = 42.4 bits (98), Expect = 6e-04
 Identities = 41/161 (25%), Positives = 55/161 (34%), Gaps = 29/161 (18%)

Query: 12  AGLAQFCCRVQGTGPLDTTPEGRPGEVSDAPQRKQFCHWPCKC----PQQKPRCPPG--- 64
           AG  +  C+      L +   G+PGE  D  + K      C+     P Q+  CPP    
Sbjct: 215 AGCLRKVCQPGNLNILVSKASGKPGECCDLYECKPVFGVDCRTVECPPVQQTACPPDSYE 274

Query: 65  --VSLVRDGC-----------GCCKICAKQPGEICNEADLCDPHKGLYCDYSVDRPRYET 111
             V L  DGC           G C     + G         D   G  CD       +E 
Sbjct: 275 TQVRLTADGCCTLPTRCECLSGLCGFPVCEVGSTPRIVSRGDGTPGKCCDV------FE- 327

Query: 112 GVCAYLVAVGCEFNQVHYHNGQVFQPNPLFSCLCVSGAIGC 152
             C       C FN V Y++G +F+ +    C C  G   C
Sbjct: 328 --CVNDTKPACVFNNVEYYDGDMFRMDNCRFCRCQGGVAIC 366



 Score = 39.7 bits (91), Expect = 0.004
 Identities = 32/79 (40%), Positives = 37/79 (46%), Gaps = 23/79 (29%)

Query: 51  PC---KCPQQKPRCPPGVSLVRDGCGCCKICAKQPGEICNEA----DLCDPHKGLYCDYS 103
           PC   KC  ++PR  PG S+V+  CGCC  CA Q  E C         CD  +GL C   
Sbjct: 39  PCDESKC--EEPRNCPG-SIVQGVCGCCYTCASQRNESCGGTFGIYGTCD--RGLRC--- 90

Query: 104 VDRP--------RYETGVC 114
           V RP         YE GVC
Sbjct: 91  VIRPPLNGDSLTEYEAGVC 109


>gi|114431244 von Willebrand factor C and EGF domains [Homo sapiens]
          Length = 955

 Score = 40.4 bits (93), Expect = 0.002
 Identities = 24/91 (26%), Positives = 38/91 (41%), Gaps = 12/91 (13%)

Query: 70  DGCGCCKICAKQPGEICNEADLCDPHKGLYCDYSVDRPRYETGVCAYLVAVGCEFNQVHY 129
           D C  C IC       C   D  D      C + +  P    G C    + GC +    +
Sbjct: 587 DPCELC-ICQADGSVSCKRTDCVDS-----CPHPIRIP----GQCCPDCSAGCTYTGRIF 636

Query: 130 HNGQVFQP--NPLFSCLCVSGAIGCTPLFIP 158
           +N + F    +P  SC+C+ G++ C+P+  P
Sbjct: 637 YNNETFPSVLDPCLSCICLLGSVACSPVDCP 667



 Score = 31.6 bits (70), Expect = 1.1
 Identities = 35/127 (27%), Positives = 50/127 (39%), Gaps = 23/127 (18%)

Query: 57  QKPRCPPGVSLV---RDGCGCCKICAK--QPGEICNEADLCDPHKG-------LYCDYSV 104
           +K RC    S     RDG GCC  C      G +  E D+  P          L  + S 
Sbjct: 417 EKVRCEAACSHPIPSRDG-GCCPSCTGCFHSGVVRAEGDVFSPPNENCTVCVCLAGNVSC 475

Query: 105 DRPRYETGVC--------AYLVAVGCEFNQVHYHNGQVFQP--NPLFSCLCVSGAIGCTP 154
             P   +G C           V V C F+   Y +G VF    +   +C+C +G + C+ 
Sbjct: 476 ISPECPSGPCQTPPQTDCCTCVPVRCYFHGRWYADGAVFSGGGDECTTCVCQNGEVECSF 535

Query: 155 LFIPKLA 161
           +  P+LA
Sbjct: 536 MPCPELA 542


>gi|4506141 HtrA serine peptidase 1 precursor [Homo sapiens]
          Length = 480

 Score = 39.7 bits (91), Expect = 0.004
 Identities = 15/36 (41%), Positives = 19/36 (52%), Gaps = 2/36 (5%)

Query: 51 PCKCPQQKPRCPPGVSLVRDGCGCCKICAKQPGEIC 86
          P +CP Q   C  G +  RD CGCC++C    G  C
Sbjct: 43 PARCPPQPEHCEGGRA--RDACGCCEVCGAPEGAAC 76


>gi|22129776 HtrA serine peptidase 3 [Homo sapiens]
          Length = 453

 Score = 39.3 bits (90), Expect = 0.005
 Identities = 23/62 (37%), Positives = 28/62 (45%), Gaps = 4/62 (6%)

Query: 53  KCPQQKPRCPPGVSLVRDGCGCCKICAKQPGEICNEADLCDPHKGLYCDYSVDRPRYETG 112
           +CP   PRCP G   V D C CC +CA   GE C         + L C   + R R+   
Sbjct: 33  RCPS--PRCPGGY--VPDLCNCCLVCAASEGEPCGGPLDSPCGESLECVRGLCRCRWSHA 88

Query: 113 VC 114
           VC
Sbjct: 89  VC 90


>gi|112789555 ADAM metallopeptidase with thrombospondin type 1
           motif, 19 preproprotein [Homo sapiens]
          Length = 1207

 Score = 39.3 bits (90), Expect = 0.005
 Identities = 19/48 (39%), Positives = 28/48 (58%), Gaps = 7/48 (14%)

Query: 216 WTPCSRTCGMGISNR------VTNENSNCE-MRKEKRLCYIQPCDSNI 256
           W+PCSRTC  GIS+R      + +E  +C   RK+ R+C   PC + +
Sbjct: 642 WSPCSRTCSAGISSRERKCPGLDSEARDCNGPRKQYRICENPPCPAGL 689



 Score = 37.4 bits (85), Expect = 0.021
 Identities = 24/70 (34%), Positives = 34/70 (48%), Gaps = 13/70 (18%)

Query: 208  KCLV-QATKWTPCSRTCGMGISNRVT-----------NENSNCEMRKEKRLCYIQPCDSN 255
            KC V +   W+ CS TCG G+ +RV            NE  + E     R C++QPC+  
Sbjct: 1087 KCYVWRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRPCHLQPCNEK 1146

Query: 256  I-LKTIKIPK 264
            I + TI  P+
Sbjct: 1147 INVNTITSPR 1156



 Score = 35.4 bits (80), Expect = 0.078
 Identities = 24/76 (31%), Positives = 36/76 (47%), Gaps = 12/76 (15%)

Query: 214  TKWTPCSRTCGMGISNR---VTNENSNCEMRKEKRLCYIQPCDSNILKTIKIPKGKTCQP 270
            T+WTPCSRTCG G+ +R    T + SN  + + +    I P         K    + C+ 
Sbjct: 983  TEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCIGP---------KPASAQRCEG 1033

Query: 271  TFQLSKAEKFVFSGCS 286
               ++  E  V+S CS
Sbjct: 1034 QDCMTVWEAGVWSECS 1049



 Score = 28.9 bits (63), Expect = 7.3
 Identities = 18/71 (25%), Positives = 25/71 (35%), Gaps = 16/71 (22%)

Query: 214 TKWTPCSRTCGMGISNRVTN------------ENSNCEM----RKEKRLCYIQPCDSNIL 257
           T W  C  TCG G      +            +N  C+       + R C  QPC +  +
Sbjct: 922 TSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNEQPCQTRWM 981

Query: 258 KTIKIPKGKTC 268
            T   P  +TC
Sbjct: 982 MTEWTPCSRTC 992


>gi|40317626 thrombospondin 1 precursor [Homo sapiens]
          Length = 1170

 Score = 38.9 bits (89), Expect = 0.007
 Identities = 34/140 (24%), Positives = 48/140 (34%), Gaps = 36/140 (25%)

Query: 122 CEFNQVHYHNGQVFQPNPLFSCLCVSGAIGCTPLFIPKLAGSHCSGAKGGKKSDQSNCSL 181
           C  N V Y N + +  +    C C +    C  +  P +    CS A             
Sbjct: 318 CYHNGVQYRNNEEWTVDSCTECHCQNSVTICKKVSCPIMP---CSNA------------- 361

Query: 182 EPLLQQLSTSYKTMPAYRNLPLIWKKKCLVQA----TKWTPCSRTCGMGISNR---VTNE 234
                       T+P     P  W            ++WT CS +CG GI  R     + 
Sbjct: 362 ------------TVPDGECCPRCWPSDSADDGWSPWSEWTSCSTSCGNGIQQRGRSCDSL 409

Query: 235 NSNCE-MRKEKRLCYIQPCD 253
           N+ CE    + R C+IQ CD
Sbjct: 410 NNRCEGSSVQTRTCHIQECD 429


>gi|4504619 insulin-like growth factor binding protein 7 [Homo
           sapiens]
          Length = 282

 Score = 38.1 bits (87), Expect = 0.012
 Identities = 26/71 (36%), Positives = 31/71 (43%), Gaps = 11/71 (15%)

Query: 51  PCKCPQQKPRCPPGVSL--VRDGCGCCKICAKQPGEICNEA----DLCDPHKGLYCDYSV 104
           P  CP   P  P G  L   RD CGCC +CA+  GE C         C P  G+ C  S 
Sbjct: 37  PASCP---PLPPLGCLLGETRDACGCCPMCARGEGEPCGGGGAGRGYCAP--GMECVKSR 91

Query: 105 DRPRYETGVCA 115
            R + + G  A
Sbjct: 92  KRRKGKAGAAA 102


>gi|209571519 cysteine rich BMP regulator 2 isoform 1 [Homo sapiens]
          Length = 1503

 Score = 37.4 bits (85), Expect = 0.021
 Identities = 28/110 (25%), Positives = 39/110 (35%), Gaps = 37/110 (33%)

Query: 52  CKCPQQKPRC-------PPGVSLVRDGCGCCKICAKQPGEICNE-ADLCDPHKGL-YCDY 102
           C+C    P+C       P G     D C  C         +C + A  C P   L +C  
Sbjct: 87  CECHPASPQCWGLGRAWPEGARWEPDACTAC---------VCQDGAAHCGPQAHLPHCR- 136

Query: 103 SVDRPRYETGVCAYLVAVGCEFNQVHYHNGQVFQPNPLFSCLCVSGAIGC 152
                             GC  N   Y NG+ F P+   +C C++GA+ C
Sbjct: 137 ------------------GCSQNGQTYGNGETFSPDACTTCRCLTGAVQC 168



 Score = 32.3 bits (72), Expect = 0.66
 Identities = 26/92 (28%), Positives = 37/92 (40%), Gaps = 11/92 (11%)

Query: 75  CKICAKQPGEI-CNEADLCDPHKGLYCDYSVDRPRYETGVCAYLVAVGCEFNQVHYHNGQ 133
           C+IC    G I C + +         C Y     R   G C   V  GC  N   + +G+
Sbjct: 213 CRICRCLEGHIQCRQRECAS-----LCPYPA---RPLPGTCCP-VCDGCFLNGREHRSGE 263

Query: 134 -VFQPNPLFSCLCVSGAIGCTPLFIPKLAGSH 164
            V   +P   C C +G++ C PL  P +   H
Sbjct: 264 PVGSGDPCSHCRCANGSVQCEPLPCPPVPCRH 295



 Score = 30.0 bits (66), Expect = 3.3
 Identities = 38/148 (25%), Positives = 50/148 (33%), Gaps = 33/148 (22%)

Query: 44  RKQFCHWPCKCPQQKPRCP-----PGVSLVRDGCGC-------------------CKICA 79
           R Q  H  C+ P+  PR P     PG     D  GC                   C++C 
Sbjct: 508 RCQEGHAHCQ-PRPCPRAPCAHPLPGTCCPNDCSGCAFGGKEYPSGADFPHPSDPCRLCR 566

Query: 80  KQPGEICNEADLCDPHKGLYCDYSVDRPRYETGVCAYLVAVGCEF-NQVHYHNGQVFQP- 137
              G +   A  C P   L C   V  P      C      GC      H  + + F P 
Sbjct: 567 CLSGNVQCLARRCVP---LPCPEPVLLPGECCPQCP--APAGCPRPGAAHARHQEYFSPP 621

Query: 138 -NPLFSCLCVSGAIGCTPLFIPKLAGSH 164
            +P   CLC+ G++ C  L  P    +H
Sbjct: 622 GDPCRRCLCLDGSVSCQRLPCPPAPCAH 649



 Score = 29.6 bits (65), Expect = 4.3
 Identities = 41/183 (22%), Positives = 56/183 (30%), Gaps = 36/183 (19%)

Query: 51  PCKCPQQKPRCPPGVSLVRDG------------CGCCKICAKQPGEICNEADLCDPHKGL 98
           PC  P+Q P CP     +  G               C +C    G +  E   C P    
Sbjct: 646 PCAHPRQGPCCPSCDGCLYQGKEFASGERFPSPTAACHLCLCWEGSVSCEPKACAP---A 702

Query: 99  YCDYSVDRPRYETGVCAYLVAVGCEFNQVHYHNGQVFQP--NPLFSCLCVSGAI------ 150
            C +         G C      GCE+    Y + Q F     P   C C+ G +      
Sbjct: 703 LCPFPA------RGDCC-PDCDGCEYLGESYLSNQEFPDPREPCNLCTCLGGFVTCGRRP 755

Query: 151 ----GCTPLFIPKLAGSHCSGAKGGKKSDQSNCSLEPLLQQLSTSYKTMPAYRNLPLIWK 206
               GC+   IP  +G  C   +G +    +  S E L   L  +              K
Sbjct: 756 CEPPGCSHPLIP--SGHCCPTCQGCRYHGVTTASGETLPDPLDPTCSLCTCQEGSMRCQK 813

Query: 207 KKC 209
           K C
Sbjct: 814 KPC 816


>gi|134031945 SCO-spondin [Homo sapiens]
          Length = 5147

 Score = 37.4 bits (85), Expect = 0.021
 Identities = 56/244 (22%), Positives = 86/244 (35%), Gaps = 40/244 (16%)

Query: 26   PLDTTPEGRPGEVSDAPQRKQFCHWPC--KCPQQKPRCPPGVSLVRDGCGCCKICAKQ-P 82
            P DTT  G   +  D   +      PC  +CP+            ++G  C ++C  Q P
Sbjct: 2862 PGDTTCPGPHSQTRDCNTQ------PCTAQCPENM-LFRSAEQCHQEGGPCPRLCLTQGP 2914

Query: 83   GEICNE--ADLCDPHKGLYCDYSVDRPRYETGVCAYLVAVGCEFNQVHYHNGQVFQPNPL 140
            G  C    A  C    GL+   +   PR +           C+ +   Y +G + + +  
Sbjct: 2915 GIECTGFCAPGCTCPPGLFLHNASCLPRSQCP---------CQLHGQLYASGAMARLDSC 2965

Query: 141  FSCLCVSGAIGCTPLFIPKLAG---------SHCSGAKGGKKSDQSNCSLEPLLQQLSTS 191
             +C CVSG + CT    P   G           CS   G ++  ++  +           
Sbjct: 2966 NNCTCVSGKMACTSERCPVACGWSPWTLWSLCSCSCNVGIRRRFRAGTAPPAAFGGAECQ 3025

Query: 192  YKTMPAYRNLPLIWKKKCLVQATK---WTPCSRTCGMGISNRVTNENSNCEMRKEKRLCY 248
              TM A         + C     +   W+PCS  CG G  NR    + +     E   C 
Sbjct: 3026 GPTMEA----EFCSLRPCPGPGGEWGPWSPCSVPCGGGYRNRTRGSSRSL---MEFSTCG 3078

Query: 249  IQPC 252
            +QPC
Sbjct: 3079 LQPC 3082



 Score = 37.4 bits (85), Expect = 0.021
 Identities = 40/148 (27%), Positives = 53/148 (35%), Gaps = 29/148 (19%)

Query: 23   GTGPLDTTPEGRPG----EVSDAPQRKQFCHWPCKCPQQKPRCPPGVSLVRDGCGCCKIC 78
            GT     T EG PG    +  D  QR++    PC      P CPPG  L      C  +C
Sbjct: 4782 GTMERHRTCEGGPGVAPCQAQDTEQRQECNLQPC------PECPPGQVLSACATSCPCLC 4835

Query: 79   -AKQPGEICNEADLCDPHKGLYCDYSVDRPRYETGVCAYLVAVGCEFNQVHY-------H 130
               QPG IC + + C P  G  C           G C    A  C  + + +        
Sbjct: 4836 WHLQPGAICVQ-EPCQP--GCGCP---GGQLLHNGTCVPPTACPCTQHSLPWGLTLTLEE 4889

Query: 131  NGQVFQPNPLFS-----CLCVSGAIGCT 153
              Q   P  + +     C+C  GA  C+
Sbjct: 4890 QAQELPPGTVLTRNCTRCVCHGGAFSCS 4917



 Score = 37.0 bits (84), Expect = 0.027
 Identities = 42/179 (23%), Positives = 65/179 (36%), Gaps = 38/179 (21%)

Query: 130  HNGQVFQPN-----PLFSCLCVSGAIG-CT--------PLFIPKLAGSHCSGAKGGKKSD 175
            H G ++ P      P  +C CVSG I  C+        P + P    S CS + G  +  
Sbjct: 3146 HEGHLYPPGSTVVRPCENCSCVSGLIANCSSWPCAEGEPTWSPWTPWSQCSASCGPARCH 3205

Query: 176  QSN-CSLEPLLQQLSTSYKTMPAYRNL----PLIWKKKCLVQATK----------WTPCS 220
            +   C+  P     + +   +PA        P   ++ CL+Q             W+ CS
Sbjct: 3206 RHRFCARSPSAVPSTVAPLPLPATPTPLCSGPEAEEEPCLLQGCDRAGGWGPWGPWSHCS 3265

Query: 221  RTCGMGISNRV--------TNENSNCE-MRKEKRLCYIQPCDSNILKTIKIPKGKTCQP 270
            R+CG G+ +R               CE  R +  +C   PC       I+  +   C P
Sbjct: 3266 RSCGGGLRSRTRACDQPPPQGLGDYCEGPRAQGEVCQALPCPVTNCTAIEGAEYSPCGP 3324



 Score = 35.0 bits (79), Expect = 0.10
 Identities = 62/301 (20%), Positives = 103/301 (34%), Gaps = 75/301 (24%)

Query: 29   TTPEGRPGEVSDAPQRKQ--FCHWPCKCPQQKPRCPPGVSLVRDGCGCCKICAK-QPGEI 85
            ++P  + G    A +R Q   C+ P  C   +  CP G+ +V     C + C+  Q G +
Sbjct: 4032 SSPPSKNGGAPCAGERHQARLCN-PMPC---EAGCPAGMEVVTCANRCPRRCSDLQEGIV 4087

Query: 86   CNEADLCDPHKGLYCDYSVDRPRYETGVCAYLVAVGCEFNQVHYHNGQVFQPNPLFSCLC 145
            C +  +C   KG  C         + G C  +    C   Q H         +   +C C
Sbjct: 4088 CQDDQVCQ--KGCRCPKG---SLEQDGGCVPIGHCDCTDAQGHSWAPGSQHQDACNNCSC 4142

Query: 146  VSGAIGCTPLFIPKLAGSHCSGAKGGKKSDQSNCSLEPLLQQLSTSYKTMPAYRNLPLIW 205
             +G + CT    P    +HC+ +                                    W
Sbjct: 4143 QAGQLSCTAQPCPP--PTHCAWSH-----------------------------------W 4165

Query: 206  KKKCLVQATKWTPCSRTCG-MGISNRVTNENSNC---EMRKEKRLCYIQPCDSNILKTIK 261
                    + W+PCS +CG  G  +R  +  S     E R+E+     QPC       + 
Sbjct: 4166 --------SAWSPCSHSCGPRGQQSRFRSSTSGSWAPECREEQ--SQSQPCPQPSCPPLC 4215

Query: 262  I--PKGKTCQPTFQLSKAEKFVFSGCSSTQSYKPTFCGICLDKRCCIPNKSKMITIQFDC 319
            +   + +T   ++   + ++     CS T         IC D  C +P    + +   DC
Sbjct: 4216 LQGTRSRTLGDSWLQGECQR-----CSCTPEGV-----ICEDTECAVPEAWTLWSSWSDC 4265

Query: 320  P 320
            P
Sbjct: 4266 P 4266



 Score = 30.0 bits (66), Expect = 3.3
 Identities = 18/61 (29%), Positives = 29/61 (47%), Gaps = 9/61 (14%)

Query: 177  SNCSLEPLLQQLSTSYKTMPAYRNLPLIWKKKCLVQATKWT------PCSRTCGMGISNR 230
            +NC++   LQ+   +   +P+   LP+     C      WT      PCSR+CG+G   R
Sbjct: 3913 ANCTMGDPLQERPCN---LPSCTELPVCPGPGCGAGNCSWTSWAPWEPCSRSCGVGQQRR 3969

Query: 231  V 231
            +
Sbjct: 3970 L 3970



 Score = 30.0 bits (66), Expect = 3.3
 Identities = 13/32 (40%), Positives = 19/32 (59%), Gaps = 2/32 (6%)

Query: 216  WTPCSRTCGMGISNRVTNENSNCEMRKEKRLC 247
            W PCSR+CG G+++R  + +  C M K    C
Sbjct: 4316 WGPCSRSCGPGLASR--SGSCPCLMAKADPTC 4345


>gi|55925576 insulin-like growth factor binding protein 2, 36kDa
           [Homo sapiens]
          Length = 328

 Score = 37.0 bits (84), Expect = 0.027
 Identities = 18/43 (41%), Positives = 22/43 (51%), Gaps = 8/43 (18%)

Query: 63  PGVSLVRD-GCGCCKICAKQPGEI-------CNEADLCDPHKG 97
           P   LVR+ GCGCC +CA+  GE        C +   C PH G
Sbjct: 77  PCAELVREPGCGCCSVCARLEGEACGVYTPRCGQGLRCYPHPG 119


>gi|209571521 cysteine rich BMP regulator 2 isoform 2 [Homo sapiens]
          Length = 814

 Score = 37.0 bits (84), Expect = 0.027
 Identities = 41/183 (22%), Positives = 61/183 (33%), Gaps = 50/183 (27%)

Query: 52  CKCPQQKPRC-------PPGVSLVRDGCGCCKICAKQPGEICNE-ADLCDPHKGL-YCDY 102
           C+C    P+C       P G     D C  C         +C + A  C P   L +C  
Sbjct: 87  CECHPASPQCWGLGRAWPEGARWEPDACTAC---------VCQDGAAHCGPQAHLPHCR- 136

Query: 103 SVDRPRYETGVCAYLVAVGCEFNQVHYHNGQVFQPNPLFSCLCVSGAIGCTPLFIPK--- 159
                             GC  N   Y NG+ F P+   +C C+ G I C     P+   
Sbjct: 137 ------------------GCSQNGQTYGNGETFSPDACTTCRCLEGTITCNQKPCPRGPC 178

Query: 160 -LAGSHCSGAKGGKKSDQSNCSLEPLLQQLSTSY--KTMPAYRNLPLIWKKKCLVQATKW 216
              G+ C   K G       C  E  L +   ++   + P  +   L  + +C+      
Sbjct: 179 PEPGACCPHCKPG-------CDYEGQLYEEGVTFLSSSNPCLQCTCLRSRVRCMALKCPP 231

Query: 217 TPC 219
           +PC
Sbjct: 232 SPC 234



 Score = 32.3 bits (72), Expect = 0.66
 Identities = 26/92 (28%), Positives = 37/92 (40%), Gaps = 11/92 (11%)

Query: 75  CKICAKQPGEI-CNEADLCDPHKGLYCDYSVDRPRYETGVCAYLVAVGCEFNQVHYHNGQ 133
           C+IC    G I C + +         C Y     R   G C   V  GC  N   + +G+
Sbjct: 271 CRICRCLEGHIQCRQRECAS-----LCPYPA---RPLPGTCCP-VCDGCFLNGREHRSGE 321

Query: 134 -VFQPNPLFSCLCVSGAIGCTPLFIPKLAGSH 164
            V   +P   C C +G++ C PL  P +   H
Sbjct: 322 PVGSGDPCSHCRCANGSVQCEPLPCPPVPCRH 353



 Score = 30.4 bits (67), Expect = 2.5
 Identities = 39/149 (26%), Positives = 51/149 (34%), Gaps = 32/149 (21%)

Query: 44  RKQFCHWPCKCPQQKPRCP-----PGVSLVRDGCGC-------------------CKICA 79
           R Q  H  C+ P+  PR P     PG     D  GC                   C++C 
Sbjct: 566 RCQEGHAHCQ-PRPCPRAPCAHPLPGTCCPNDCSGCAFGGKEYPSGADFPHPSDPCRLCR 624

Query: 80  KQPGEICNEADLCDPHKGLYCDYSVDRPRYETGVCAYLVA-VGCEF-NQVHYHNGQVFQP 137
              G +   A  C P   L C   V  P      C    A  GC      H  + + F P
Sbjct: 625 CLSGNVQCLARRCVP---LPCPEPVLLPGECCPQCPAAPAPAGCPRPGAAHARHQEYFSP 681

Query: 138 --NPLFSCLCVSGAIGCTPLFIPKLAGSH 164
             +P   CLC+ G++ C  L  P    +H
Sbjct: 682 PGDPCRRCLCLDGSVSCQRLPCPPAPCAH 710


>gi|150170672 thrombospondin, type I, domain containing 7A [Homo
           sapiens]
          Length = 1657

 Score = 37.0 bits (84), Expect = 0.027
 Identities = 19/72 (26%), Positives = 37/72 (51%), Gaps = 9/72 (12%)

Query: 206 KKKCLV-QATKWTPCSRTCGMGISNRVTN-------ENSNCEMRKEKRLCYIQPCDSNIL 257
           ++ C+V + + W+ CS+TCG G+ +R  +         S C    E ++C   PC++  L
Sbjct: 192 QQDCIVSEFSAWSECSKTCGSGLQHRTRHVVAPPQFGGSGCPNLTEFQVCQSSPCEAEEL 251

Query: 258 K-TIKIPKGKTC 268
           + ++ +    TC
Sbjct: 252 RYSLHVGPWSTC 263



 Score = 28.5 bits (62), Expect = 9.5
 Identities = 18/56 (32%), Positives = 25/56 (44%), Gaps = 13/56 (23%)

Query: 169 KGGKKSDQSNCSLEPLLQQLSTSYKTMPAYRNLPLIWKKKCLVQA-TKWTPCSRTC 223
           K GK +D S C  E L     +   T            K+C V   ++W+PCS+TC
Sbjct: 333 KTGKAADLSFCQQEKLPMTFQSCVIT------------KECQVSEWSEWSPCSKTC 376


>gi|110347423 spondin 1, extracellular matrix protein [Homo sapiens]
          Length = 807

 Score = 36.6 bits (83), Expect = 0.035
 Identities = 27/110 (24%), Positives = 49/110 (44%), Gaps = 16/110 (14%)

Query: 158 PKLAGSHCSGAKGGKKSDQSNCSLEPLLQQLSTSYKTMPAYRNLPLIWKKK------CLV 211
           P+  G+ C      KK     C   P +Q+L    +   + R+  L  + +      C +
Sbjct: 699 PQFGGAPCPETVQRKKCRIRKCLRNPSIQKLRWR-EARESRRSEQLKEESEGEQFPGCRM 757

Query: 212 QA-TKWTPCSRTCGMGISNRV--------TNENSNCEMRKEKRLCYIQPC 252
           +  T W+ C++ CG GI  R         +++ ++C+ +KE R C + PC
Sbjct: 758 RPWTAWSECTKLCGGGIQERYMTVKKRFKSSQFTSCKDKKEIRACNVHPC 807



 Score = 29.6 bits (65), Expect = 4.3
 Identities = 19/71 (26%), Positives = 28/71 (39%), Gaps = 26/71 (36%)

Query: 215 KWTPCSRTCGMGISNRVTNENSNCEMRKEKRLCYIQPCDSNILKTIKIPKGKTCQPTFQL 274
           +W  CS TCGMG             M+K  R+  + P D ++ K              + 
Sbjct: 566 EWDECSATCGMG-------------MKKRHRMIKMNPADGSMCKA-------------ET 599

Query: 275 SKAEKFVFSGC 285
           S+AEK +   C
Sbjct: 600 SQAEKCMMPEC 610



 Score = 29.3 bits (64), Expect = 5.6
 Identities = 25/88 (28%), Positives = 42/88 (47%), Gaps = 16/88 (18%)

Query: 216 WTPCSRTCGMGISNRVTNENSNCEMRKEKRLCYIQPCDSNILKTIKIPKGKTCQPTFQLS 275
           W+PCS +CGMG+ +R   E    +  ++  +C + P +    +T K    + C P+  L 
Sbjct: 510 WSPCSISCGMGMRSR---ERYVKQFPEDGSVCTL-PTE----ETEKCTVNEECSPSSCL- 560

Query: 276 KAEKFVFSGCSSTQSYKPTFCGICLDKR 303
             E   +  CS+T       CG+ + KR
Sbjct: 561 MTEWGEWDECSAT-------CGMGMKKR 581


>gi|24308541 HtrA serine peptidase 4 precursor [Homo sapiens]
          Length = 476

 Score = 36.6 bits (83), Expect = 0.035
 Identities = 18/50 (36%), Positives = 23/50 (46%), Gaps = 1/50 (2%)

Query: 51  PCKCPQQKPRCPPGVSLVRDGCGCCKICAKQPGEICNEADLCDPHKGLYC 100
           P +CP   P C  G + V D C CC++C     E+C  A       GL C
Sbjct: 46  PTRCPAL-PTCALGTTPVFDLCRCCRVCPAAEREVCGGAQGQPCAPGLQC 94


>gi|50845384 ADAM metallopeptidase with thrombospondin type 1 motif,
           1 preproprotein [Homo sapiens]
          Length = 967

 Score = 36.2 bits (82), Expect = 0.046
 Identities = 28/107 (26%), Positives = 45/107 (42%), Gaps = 16/107 (14%)

Query: 216 WTPCSRTCGMGISNRV--------TNENSNCEMRKEK-RLCYIQPCDSNILKTIKIPKGK 266
           W  CSRTCG G+   +         N    CE ++ + R C ++ C  N  KT    + +
Sbjct: 568 WGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVRYRSCNLEDCPDNNGKTF---REE 624

Query: 267 TCQPTFQLSKAEKFVFSGCSSTQSYKPTFCGICLDKRCCIPNKSKMI 313
            C+   + SKA      G      + P + G+    RC +  ++K I
Sbjct: 625 QCEAHNEFSKAS----FGSGPAVEWIPKYAGVSPKDRCKLICQAKGI 667


>gi|5901946 endothelial cell-specific molecule 1 isoform a precursor
           [Homo sapiens]
          Length = 184

 Score = 35.4 bits (80), Expect = 0.078
 Identities = 26/77 (33%), Positives = 31/77 (40%), Gaps = 21/77 (27%)

Query: 54  CPQQ--------KPRCPPGVSLVRDGCGCCKICAKQPGEIC------NEADLCDPHKGLY 99
           CPQ          PRC      V D CGCC++CA   GE C       +   C P  GL 
Sbjct: 28  CPQHCDSSECKSSPRCK---RTVLDDCGCCRVCAAGRGETCYRTVSGMDGMKCGP--GLR 82

Query: 100 CDYSVDRPRY--ETGVC 114
           C  S     +  E G+C
Sbjct: 83  CQPSNGEDPFGEEFGIC 99


>gi|208022668 endothelial cell-specific molecule 1 isoform b
           precursor [Homo sapiens]
          Length = 134

 Score = 35.4 bits (80), Expect = 0.078
 Identities = 26/77 (33%), Positives = 31/77 (40%), Gaps = 21/77 (27%)

Query: 54  CPQQ--------KPRCPPGVSLVRDGCGCCKICAKQPGEIC------NEADLCDPHKGLY 99
           CPQ          PRC      V D CGCC++CA   GE C       +   C P  GL 
Sbjct: 28  CPQHCDSSECKSSPRCK---RTVLDDCGCCRVCAAGRGETCYRTVSGMDGMKCGP--GLR 82

Query: 100 CDYSVDRPRY--ETGVC 114
           C  S     +  E G+C
Sbjct: 83  CQPSNGEDPFGEEFGIC 99


>gi|56090548 insulin-like growth factor binding protein-like 1 [Homo
           sapiens]
          Length = 278

 Score = 35.4 bits (80), Expect = 0.078
 Identities = 28/83 (33%), Positives = 34/83 (40%), Gaps = 10/83 (12%)

Query: 38  VSDAPQRKQFCHWPCK---CPQQKPRCPPGVSLVRDGCGCCKICAKQPGEIC--NEADLC 92
           + D   R+  C  PC+   CP   P   PG+S + D CGCC  C    G  C       C
Sbjct: 28  IRDVGGRRPKCG-PCRPEGCPAPAPCPAPGISAL-DECGCCARCLGAEGASCGGRAGGRC 85

Query: 93  DPHKGLYCDYSVDRPRYE-TGVC 114
            P  GL C         E TG+C
Sbjct: 86  GP--GLVCASQAAGAAPEGTGLC 106


>gi|4759146 slit homolog 2 [Homo sapiens]
          Length = 1529

 Score = 34.7 bits (78), Expect = 0.13
 Identities = 17/59 (28%), Positives = 28/59 (47%), Gaps = 1/59 (1%)

Query: 282  FSGCSSTQSYKPTFC-GICLDKRCCIPNKSKMITIQFDCPNEGSFKWKMLWITSCVCQR 339
            ++ C +T+      C G C   +CC P +SK     F+C +  SF  ++  +  C C R
Sbjct: 1468 YAACQTTKKVSRLECRGGCAGGQCCGPLRSKRRKYSFECTDGSSFVDEVEKVVKCGCTR 1526


>gi|188528675 slit homolog 1 [Homo sapiens]
          Length = 1534

 Score = 34.3 bits (77), Expect = 0.17
 Identities = 52/247 (21%), Positives = 78/247 (31%), Gaps = 56/247 (22%)

Query: 92   CDPHKGLYCDYSVDRPRYETGVCAYLVAVGCEFNQVHYHNGQVFQPNPLFSCLCVSGAIG 151
            C+P + LYC + + +P    G   +     CE   V  H  Q     P     CV G   
Sbjct: 1339 CEPCRKLYCLHGICQPNATPGPMCH-----CEAGWVGLHCDQP-ADGPCHGHKCVHGQ-- 1390

Query: 152  CTPLFIPKLAGSHCSGAKGGKKSDQSNCSLEPLLQQLSTSYKTMPAYRNLPLIWKKKCLV 211
            C PL     +   C     G   +Q+    EP               R L  +    C  
Sbjct: 1391 CVPLDALSYS-CQCQDGYSGALCNQAGALAEPC--------------RGLQCL-HGHCQA 1434

Query: 212  QATKWTPCSRTCGMGISNRVTNENSNCEMRKEKRLCYIQPCDSNILKTIKIPKGKTCQPT 271
              TK   C   C  G S  +  + S C                         +G   +  
Sbjct: 1435 SGTKGAHC--VCDPGFSGELCEQESEC-------------------------RGDPVRDF 1467

Query: 272  FQLSKAEKFVFSGCSSTQSYKPTFC-GICLDKRCCIPNKSKMITIQFDCPNEGSFKWKML 330
             Q+ +     ++ C +T+      C G C  + CC   + K     F+C +  SF  ++ 
Sbjct: 1468 HQVQRG----YAICQTTRPLSWVECRGSCPGQGCCQGLRLKRRKFTFECSDGTSFAEEVE 1523

Query: 331  WITSCVC 337
              T C C
Sbjct: 1524 KPTKCGC 1530


>gi|37693519 BMP-binding endothelial regulator precursor protein
           [Homo sapiens]
          Length = 685

 Score = 34.3 bits (77), Expect = 0.17
 Identities = 31/126 (24%), Positives = 39/126 (30%), Gaps = 18/126 (14%)

Query: 53  KCPQQKPRCPPGVSLVRDGCGCCKICA------------KQPGEICNEADLCD---PHKG 97
           KCP     C   +      C  CK C             + P E C      +      G
Sbjct: 83  KCPVLSRDCALAIKQRGACCEQCKGCTYEGNTYNSSFKWQSPAEPCVLRQCQEGVVTESG 142

Query: 98  LYCDYSVDRPRYETGVCAYLVAVGCEFNQVHYHNGQVFQP--NPLFSCLCVSGAIGCTPL 155
           + C      P    G+C      GC F  V Y  G+ FQP  +    C C  G   C   
Sbjct: 143 VRCVVHCKNPLEHLGMCCP-TCPGCVFEGVQYQEGEEFQPEGSKCTKCSCTGGRTQCVRE 201

Query: 156 FIPKLA 161
             P L+
Sbjct: 202 VCPILS 207



 Score = 30.8 bits (68), Expect = 1.9
 Identities = 21/62 (33%), Positives = 27/62 (43%), Gaps = 9/62 (14%)

Query: 61  CPPGVSLVRDGCGCCKICAKQPGEICNEADLCDPHKGLYCDYSVDRPRYETGVCAYLVAV 120
           CP G  L R GC  C IC ++PG +C      DPH   +      R     G C Y++  
Sbjct: 342 CPQGKILNRKGC--CPICTEKPG-VCTV--FGDPHYNTF----DGRTFNFQGTCQYVLTK 392

Query: 121 GC 122
            C
Sbjct: 393 DC 394


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.138    0.473 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,661,190
Number of Sequences: 37866
Number of extensions: 875586
Number of successful extensions: 2285
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 41
Number of HSP's successfully gapped in prelim test: 77
Number of HSP's that attempted gapping in prelim test: 1968
Number of HSP's gapped (non-prelim): 382
length of query: 354
length of database: 18,247,518
effective HSP length: 103
effective length of query: 251
effective length of database: 14,347,320
effective search space: 3601177320
effective search space used: 3601177320
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.