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Search of human proteins with 4507693
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4507693 tuberous sclerosis 1 protein isoform 1 [Homo
sapiens]
(1164 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4507693 tuberous sclerosis 1 protein isoform 1 [Homo sapiens] 2340 0.0
gi|241666462 tuberous sclerosis 1 protein isoform 3 [Homo sapiens] 2334 0.0
gi|241666464 tuberous sclerosis 1 protein isoform 4 [Homo sapiens] 2216 0.0
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 74 6e-13
gi|16262452 cingulin [Homo sapiens] 68 4e-11
gi|30581135 structural maintenance of chromosomes 1A [Homo sapiens] 68 6e-11
gi|46592991 GRIP1 associated protein 1 isoform 1 [Homo sapiens] 64 1e-09
gi|210032790 hypothetical protein LOC27146 [Homo sapiens] 63 1e-09
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 62 4e-09
gi|38044112 restin isoform b [Homo sapiens] 62 4e-09
gi|4506751 restin isoform a [Homo sapiens] 62 4e-09
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 62 4e-09
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 62 4e-09
gi|46593000 GRIP1 associated protein 1 isoform 2 [Homo sapiens] 61 5e-09
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 60 9e-09
gi|223634475 golgi autoantigen, golgin subfamily a, 6D [Homo sap... 60 1e-08
gi|51472437 PREDICTED: golgi autoantigen, golgin subfamily a, 6C... 60 1e-08
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 60 2e-08
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 59 2e-08
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 59 2e-08
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 59 2e-08
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 59 2e-08
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 59 2e-08
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 59 2e-08
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 59 2e-08
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 59 2e-08
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 59 2e-08
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 59 2e-08
gi|169208018 PREDICTED: similar to Golgin subfamily A member 8-l... 58 5e-08
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 58 5e-08
>gi|4507693 tuberous sclerosis 1 protein isoform 1 [Homo sapiens]
Length = 1164
Score = 2340 bits (6064), Expect = 0.0
Identities = 1164/1164 (100%), Positives = 1164/1164 (100%)
Query: 1 MAQQANVGELLAMLDSPMLGVRDDVTAVFKENLNSDRGPMLVNTLVDYYLETSSQPALHI 60
MAQQANVGELLAMLDSPMLGVRDDVTAVFKENLNSDRGPMLVNTLVDYYLETSSQPALHI
Sbjct: 1 MAQQANVGELLAMLDSPMLGVRDDVTAVFKENLNSDRGPMLVNTLVDYYLETSSQPALHI 60
Query: 61 LTTLQEPHDKHLLDRINEYVGKAATRLSILSLLGHVIRLQPSWKHKLSQAPLLPSLLKCL 120
LTTLQEPHDKHLLDRINEYVGKAATRLSILSLLGHVIRLQPSWKHKLSQAPLLPSLLKCL
Sbjct: 61 LTTLQEPHDKHLLDRINEYVGKAATRLSILSLLGHVIRLQPSWKHKLSQAPLLPSLLKCL 120
Query: 121 KMDTDVVVLTTGVLVLITMLPMIPQSGKQHLLDFFDIFGRLSSWCLKKPGHVAEVYLVHL 180
KMDTDVVVLTTGVLVLITMLPMIPQSGKQHLLDFFDIFGRLSSWCLKKPGHVAEVYLVHL
Sbjct: 121 KMDTDVVVLTTGVLVLITMLPMIPQSGKQHLLDFFDIFGRLSSWCLKKPGHVAEVYLVHL 180
Query: 181 HASVYALFHRLYGMYPCNFVSFLRSHYSMKENLETFEEVVKPMMEHVRIHPELVTGSKDH 240
HASVYALFHRLYGMYPCNFVSFLRSHYSMKENLETFEEVVKPMMEHVRIHPELVTGSKDH
Sbjct: 181 HASVYALFHRLYGMYPCNFVSFLRSHYSMKENLETFEEVVKPMMEHVRIHPELVTGSKDH 240
Query: 241 ELDPRRWKRLETHDVVIECAKISLDPTEASYEDGYSVSHQISARFPHRSADVTTSPYADT 300
ELDPRRWKRLETHDVVIECAKISLDPTEASYEDGYSVSHQISARFPHRSADVTTSPYADT
Sbjct: 241 ELDPRRWKRLETHDVVIECAKISLDPTEASYEDGYSVSHQISARFPHRSADVTTSPYADT 300
Query: 301 QNSYGCATSTPYSTSRLMLLNMPGQLPQTLSSPSTRLITEPPQATLWSPSMVCGMTTPPT 360
QNSYGCATSTPYSTSRLMLLNMPGQLPQTLSSPSTRLITEPPQATLWSPSMVCGMTTPPT
Sbjct: 301 QNSYGCATSTPYSTSRLMLLNMPGQLPQTLSSPSTRLITEPPQATLWSPSMVCGMTTPPT 360
Query: 361 SPGNVPPDLSHPYSKVFGTTAGGKGTPLGTPATSPPPAPLCHSDDYVHISLPQATVTPPR 420
SPGNVPPDLSHPYSKVFGTTAGGKGTPLGTPATSPPPAPLCHSDDYVHISLPQATVTPPR
Sbjct: 361 SPGNVPPDLSHPYSKVFGTTAGGKGTPLGTPATSPPPAPLCHSDDYVHISLPQATVTPPR 420
Query: 421 KEERMDSARPCLHRQHHLLNDRGSEEPPGSKGSVTLSDLPGFLGDLASEEDSIEKDKEEA 480
KEERMDSARPCLHRQHHLLNDRGSEEPPGSKGSVTLSDLPGFLGDLASEEDSIEKDKEEA
Sbjct: 421 KEERMDSARPCLHRQHHLLNDRGSEEPPGSKGSVTLSDLPGFLGDLASEEDSIEKDKEEA 480
Query: 481 AISRELSEITTAEAEPVVPRGGFDSPFYRDSLPGSQRKTHSAASSSQGASVNPEPLHSSL 540
AISRELSEITTAEAEPVVPRGGFDSPFYRDSLPGSQRKTHSAASSSQGASVNPEPLHSSL
Sbjct: 481 AISRELSEITTAEAEPVVPRGGFDSPFYRDSLPGSQRKTHSAASSSQGASVNPEPLHSSL 540
Query: 541 DKLGPDTPKQAFTPIDLPCGSADESPAGDRECQTSLETSIFTPSPCKIPPPTRVGFGSGQ 600
DKLGPDTPKQAFTPIDLPCGSADESPAGDRECQTSLETSIFTPSPCKIPPPTRVGFGSGQ
Sbjct: 541 DKLGPDTPKQAFTPIDLPCGSADESPAGDRECQTSLETSIFTPSPCKIPPPTRVGFGSGQ 600
Query: 601 PPPYDHLFEVALPKTAHHFVIRKTEELLKKAKGNTEEDGVPSTSPMEVLDRLIQQGADAH 660
PPPYDHLFEVALPKTAHHFVIRKTEELLKKAKGNTEEDGVPSTSPMEVLDRLIQQGADAH
Sbjct: 601 PPPYDHLFEVALPKTAHHFVIRKTEELLKKAKGNTEEDGVPSTSPMEVLDRLIQQGADAH 660
Query: 661 SKELNKLPLPSKSVDWTHFGGSPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLL 720
SKELNKLPLPSKSVDWTHFGGSPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLL
Sbjct: 661 SKELNKLPLPSKSVDWTHFGGSPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLL 720
Query: 721 RKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIR 780
RKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIR
Sbjct: 721 RKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIR 780
Query: 781 QLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSES 840
QLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSES
Sbjct: 781 QLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSES 840
Query: 841 VQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQ 900
VQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQ
Sbjct: 841 VQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQ 900
Query: 901 RLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFEL 960
RLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFEL
Sbjct: 901 RLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFEL 960
Query: 961 EILDLYGRLEKDGLLKKLEEEKAEAAEAAEERLDCCNDGCSDSMVGHNEEASGHNGETKT 1020
EILDLYGRLEKDGLLKKLEEEKAEAAEAAEERLDCCNDGCSDSMVGHNEEASGHNGETKT
Sbjct: 961 EILDLYGRLEKDGLLKKLEEEKAEAAEAAEERLDCCNDGCSDSMVGHNEEASGHNGETKT 1020
Query: 1021 PRPSSARGSSGSRGGGGSSSSSSELSTPEKPPHQRAGPFSSRWETTMGEASASIPTTVGS 1080
PRPSSARGSSGSRGGGGSSSSSSELSTPEKPPHQRAGPFSSRWETTMGEASASIPTTVGS
Sbjct: 1021 PRPSSARGSSGSRGGGGSSSSSSELSTPEKPPHQRAGPFSSRWETTMGEASASIPTTVGS 1080
Query: 1081 LPSSKSFLGMKARELFRNKSESQCDEDGMTSSLSESLKTELGKDLGVEAKIPLNLDGPHP 1140
LPSSKSFLGMKARELFRNKSESQCDEDGMTSSLSESLKTELGKDLGVEAKIPLNLDGPHP
Sbjct: 1081 LPSSKSFLGMKARELFRNKSESQCDEDGMTSSLSESLKTELGKDLGVEAKIPLNLDGPHP 1140
Query: 1141 SPPTPDSVGQLHIMDYNETHHEHS 1164
SPPTPDSVGQLHIMDYNETHHEHS
Sbjct: 1141 SPPTPDSVGQLHIMDYNETHHEHS 1164
>gi|241666462 tuberous sclerosis 1 protein isoform 3 [Homo sapiens]
Length = 1163
Score = 2334 bits (6048), Expect = 0.0
Identities = 1163/1164 (99%), Positives = 1163/1164 (99%), Gaps = 1/1164 (0%)
Query: 1 MAQQANVGELLAMLDSPMLGVRDDVTAVFKENLNSDRGPMLVNTLVDYYLETSSQPALHI 60
MAQQANVGELLAMLDSPMLGVRDDVTAVFKENLNSDRGPMLVNTLVDYYLETSSQPALHI
Sbjct: 1 MAQQANVGELLAMLDSPMLGVRDDVTAVFKENLNSDRGPMLVNTLVDYYLETSSQPALHI 60
Query: 61 LTTLQEPHDKHLLDRINEYVGKAATRLSILSLLGHVIRLQPSWKHKLSQAPLLPSLLKCL 120
LTTLQEPHDKHLLDRINEYVGKAATRLSILSLLGHVIRLQPSWKHKLSQAPLLPSLLKCL
Sbjct: 61 LTTLQEPHDKHLLDRINEYVGKAATRLSILSLLGHVIRLQPSWKHKLSQAPLLPSLLKCL 120
Query: 121 KMDTDVVVLTTGVLVLITMLPMIPQSGKQHLLDFFDIFGRLSSWCLKKPGHVAEVYLVHL 180
KMDTDVVVLTTGVLVLITMLPMIPQSGKQHLLDFFDIFGRLSSWCLKKPGHVAEVYLVHL
Sbjct: 121 KMDTDVVVLTTGVLVLITMLPMIPQSGKQHLLDFFDIFGRLSSWCLKKPGHVAEVYLVHL 180
Query: 181 HASVYALFHRLYGMYPCNFVSFLRSHYSMKENLETFEEVVKPMMEHVRIHPELVTGSKDH 240
HASVYALFHRLYGMYPCNFVSFLRSHYSMKENLETFEEVVKPMMEHVRIHPELVTGSKDH
Sbjct: 181 HASVYALFHRLYGMYPCNFVSFLRSHYSMKENLETFEEVVKPMMEHVRIHPELVTGSKDH 240
Query: 241 ELDPRRWKRLETHDVVIECAKISLDPTEASYEDGYSVSHQISARFPHRSADVTTSPYADT 300
ELDPRRWKRLETHDVVIECAKISLDPTEASYEDGYSVSHQISARFPHRSADVTTSPYADT
Sbjct: 241 ELDPRRWKRLETHDVVIECAKISLDPTEASYEDGYSVSHQISARFPHRSADVTTSPYADT 300
Query: 301 QNSYGCATSTPYSTSRLMLLNMPGQLPQTLSSPSTRLITEPPQATLWSPSMVCGMTTPPT 360
QNSYGCATSTPYSTSRLMLLNMPGQLPQTLSSPSTRLITEPPQATLWSPSMVCGMTTPPT
Sbjct: 301 QNSYGCATSTPYSTSRLMLLNMPGQLPQTLSSPSTRLITEPPQATLWSPSMVCGMTTPPT 360
Query: 361 SPGNVPPDLSHPYSKVFGTTAGGKGTPLGTPATSPPPAPLCHSDDYVHISLPQATVTPPR 420
SPGNVPPDLSHPYSKVFGTT GGKGTPLGTPATSPPPAPLCHSDDYVHISLPQATVTPPR
Sbjct: 361 SPGNVPPDLSHPYSKVFGTT-GGKGTPLGTPATSPPPAPLCHSDDYVHISLPQATVTPPR 419
Query: 421 KEERMDSARPCLHRQHHLLNDRGSEEPPGSKGSVTLSDLPGFLGDLASEEDSIEKDKEEA 480
KEERMDSARPCLHRQHHLLNDRGSEEPPGSKGSVTLSDLPGFLGDLASEEDSIEKDKEEA
Sbjct: 420 KEERMDSARPCLHRQHHLLNDRGSEEPPGSKGSVTLSDLPGFLGDLASEEDSIEKDKEEA 479
Query: 481 AISRELSEITTAEAEPVVPRGGFDSPFYRDSLPGSQRKTHSAASSSQGASVNPEPLHSSL 540
AISRELSEITTAEAEPVVPRGGFDSPFYRDSLPGSQRKTHSAASSSQGASVNPEPLHSSL
Sbjct: 480 AISRELSEITTAEAEPVVPRGGFDSPFYRDSLPGSQRKTHSAASSSQGASVNPEPLHSSL 539
Query: 541 DKLGPDTPKQAFTPIDLPCGSADESPAGDRECQTSLETSIFTPSPCKIPPPTRVGFGSGQ 600
DKLGPDTPKQAFTPIDLPCGSADESPAGDRECQTSLETSIFTPSPCKIPPPTRVGFGSGQ
Sbjct: 540 DKLGPDTPKQAFTPIDLPCGSADESPAGDRECQTSLETSIFTPSPCKIPPPTRVGFGSGQ 599
Query: 601 PPPYDHLFEVALPKTAHHFVIRKTEELLKKAKGNTEEDGVPSTSPMEVLDRLIQQGADAH 660
PPPYDHLFEVALPKTAHHFVIRKTEELLKKAKGNTEEDGVPSTSPMEVLDRLIQQGADAH
Sbjct: 600 PPPYDHLFEVALPKTAHHFVIRKTEELLKKAKGNTEEDGVPSTSPMEVLDRLIQQGADAH 659
Query: 661 SKELNKLPLPSKSVDWTHFGGSPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLL 720
SKELNKLPLPSKSVDWTHFGGSPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLL
Sbjct: 660 SKELNKLPLPSKSVDWTHFGGSPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLL 719
Query: 721 RKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIR 780
RKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIR
Sbjct: 720 RKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIR 779
Query: 781 QLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSES 840
QLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSES
Sbjct: 780 QLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSES 839
Query: 841 VQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQ 900
VQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQ
Sbjct: 840 VQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQ 899
Query: 901 RLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFEL 960
RLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFEL
Sbjct: 900 RLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFEL 959
Query: 961 EILDLYGRLEKDGLLKKLEEEKAEAAEAAEERLDCCNDGCSDSMVGHNEEASGHNGETKT 1020
EILDLYGRLEKDGLLKKLEEEKAEAAEAAEERLDCCNDGCSDSMVGHNEEASGHNGETKT
Sbjct: 960 EILDLYGRLEKDGLLKKLEEEKAEAAEAAEERLDCCNDGCSDSMVGHNEEASGHNGETKT 1019
Query: 1021 PRPSSARGSSGSRGGGGSSSSSSELSTPEKPPHQRAGPFSSRWETTMGEASASIPTTVGS 1080
PRPSSARGSSGSRGGGGSSSSSSELSTPEKPPHQRAGPFSSRWETTMGEASASIPTTVGS
Sbjct: 1020 PRPSSARGSSGSRGGGGSSSSSSELSTPEKPPHQRAGPFSSRWETTMGEASASIPTTVGS 1079
Query: 1081 LPSSKSFLGMKARELFRNKSESQCDEDGMTSSLSESLKTELGKDLGVEAKIPLNLDGPHP 1140
LPSSKSFLGMKARELFRNKSESQCDEDGMTSSLSESLKTELGKDLGVEAKIPLNLDGPHP
Sbjct: 1080 LPSSKSFLGMKARELFRNKSESQCDEDGMTSSLSESLKTELGKDLGVEAKIPLNLDGPHP 1139
Query: 1141 SPPTPDSVGQLHIMDYNETHHEHS 1164
SPPTPDSVGQLHIMDYNETHHEHS
Sbjct: 1140 SPPTPDSVGQLHIMDYNETHHEHS 1163
>gi|241666464 tuberous sclerosis 1 protein isoform 4 [Homo sapiens]
Length = 1113
Score = 2216 bits (5742), Expect = 0.0
Identities = 1113/1164 (95%), Positives = 1113/1164 (95%), Gaps = 51/1164 (4%)
Query: 1 MAQQANVGELLAMLDSPMLGVRDDVTAVFKENLNSDRGPMLVNTLVDYYLETSSQPALHI 60
MAQQANVGELLAMLDSPMLGVRDDVTAVFKENLNSDRGPMLVNTLVDYYLETSSQPALHI
Sbjct: 1 MAQQANVGELLAMLDSPMLGVRDDVTAVFKENLNSDRGPMLVNTLVDYYLETSSQPALHI 60
Query: 61 LTTLQEPHDKHLLDRINEYVGKAATRLSILSLLGHVIRLQPSWKHKLSQAPLLPSLLKCL 120
LTTLQEPHD
Sbjct: 61 LTTLQEPHD--------------------------------------------------- 69
Query: 121 KMDTDVVVLTTGVLVLITMLPMIPQSGKQHLLDFFDIFGRLSSWCLKKPGHVAEVYLVHL 180
KMDTDVVVLTTGVLVLITMLPMIPQSGKQHLLDFFDIFGRLSSWCLKKPGHVAEVYLVHL
Sbjct: 70 KMDTDVVVLTTGVLVLITMLPMIPQSGKQHLLDFFDIFGRLSSWCLKKPGHVAEVYLVHL 129
Query: 181 HASVYALFHRLYGMYPCNFVSFLRSHYSMKENLETFEEVVKPMMEHVRIHPELVTGSKDH 240
HASVYALFHRLYGMYPCNFVSFLRSHYSMKENLETFEEVVKPMMEHVRIHPELVTGSKDH
Sbjct: 130 HASVYALFHRLYGMYPCNFVSFLRSHYSMKENLETFEEVVKPMMEHVRIHPELVTGSKDH 189
Query: 241 ELDPRRWKRLETHDVVIECAKISLDPTEASYEDGYSVSHQISARFPHRSADVTTSPYADT 300
ELDPRRWKRLETHDVVIECAKISLDPTEASYEDGYSVSHQISARFPHRSADVTTSPYADT
Sbjct: 190 ELDPRRWKRLETHDVVIECAKISLDPTEASYEDGYSVSHQISARFPHRSADVTTSPYADT 249
Query: 301 QNSYGCATSTPYSTSRLMLLNMPGQLPQTLSSPSTRLITEPPQATLWSPSMVCGMTTPPT 360
QNSYGCATSTPYSTSRLMLLNMPGQLPQTLSSPSTRLITEPPQATLWSPSMVCGMTTPPT
Sbjct: 250 QNSYGCATSTPYSTSRLMLLNMPGQLPQTLSSPSTRLITEPPQATLWSPSMVCGMTTPPT 309
Query: 361 SPGNVPPDLSHPYSKVFGTTAGGKGTPLGTPATSPPPAPLCHSDDYVHISLPQATVTPPR 420
SPGNVPPDLSHPYSKVFGTTAGGKGTPLGTPATSPPPAPLCHSDDYVHISLPQATVTPPR
Sbjct: 310 SPGNVPPDLSHPYSKVFGTTAGGKGTPLGTPATSPPPAPLCHSDDYVHISLPQATVTPPR 369
Query: 421 KEERMDSARPCLHRQHHLLNDRGSEEPPGSKGSVTLSDLPGFLGDLASEEDSIEKDKEEA 480
KEERMDSARPCLHRQHHLLNDRGSEEPPGSKGSVTLSDLPGFLGDLASEEDSIEKDKEEA
Sbjct: 370 KEERMDSARPCLHRQHHLLNDRGSEEPPGSKGSVTLSDLPGFLGDLASEEDSIEKDKEEA 429
Query: 481 AISRELSEITTAEAEPVVPRGGFDSPFYRDSLPGSQRKTHSAASSSQGASVNPEPLHSSL 540
AISRELSEITTAEAEPVVPRGGFDSPFYRDSLPGSQRKTHSAASSSQGASVNPEPLHSSL
Sbjct: 430 AISRELSEITTAEAEPVVPRGGFDSPFYRDSLPGSQRKTHSAASSSQGASVNPEPLHSSL 489
Query: 541 DKLGPDTPKQAFTPIDLPCGSADESPAGDRECQTSLETSIFTPSPCKIPPPTRVGFGSGQ 600
DKLGPDTPKQAFTPIDLPCGSADESPAGDRECQTSLETSIFTPSPCKIPPPTRVGFGSGQ
Sbjct: 490 DKLGPDTPKQAFTPIDLPCGSADESPAGDRECQTSLETSIFTPSPCKIPPPTRVGFGSGQ 549
Query: 601 PPPYDHLFEVALPKTAHHFVIRKTEELLKKAKGNTEEDGVPSTSPMEVLDRLIQQGADAH 660
PPPYDHLFEVALPKTAHHFVIRKTEELLKKAKGNTEEDGVPSTSPMEVLDRLIQQGADAH
Sbjct: 550 PPPYDHLFEVALPKTAHHFVIRKTEELLKKAKGNTEEDGVPSTSPMEVLDRLIQQGADAH 609
Query: 661 SKELNKLPLPSKSVDWTHFGGSPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLL 720
SKELNKLPLPSKSVDWTHFGGSPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLL
Sbjct: 610 SKELNKLPLPSKSVDWTHFGGSPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLL 669
Query: 721 RKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIR 780
RKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIR
Sbjct: 670 RKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIR 729
Query: 781 QLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSES 840
QLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSES
Sbjct: 730 QLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSES 789
Query: 841 VQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQ 900
VQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQ
Sbjct: 790 VQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQ 849
Query: 901 RLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFEL 960
RLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFEL
Sbjct: 850 RLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFEL 909
Query: 961 EILDLYGRLEKDGLLKKLEEEKAEAAEAAEERLDCCNDGCSDSMVGHNEEASGHNGETKT 1020
EILDLYGRLEKDGLLKKLEEEKAEAAEAAEERLDCCNDGCSDSMVGHNEEASGHNGETKT
Sbjct: 910 EILDLYGRLEKDGLLKKLEEEKAEAAEAAEERLDCCNDGCSDSMVGHNEEASGHNGETKT 969
Query: 1021 PRPSSARGSSGSRGGGGSSSSSSELSTPEKPPHQRAGPFSSRWETTMGEASASIPTTVGS 1080
PRPSSARGSSGSRGGGGSSSSSSELSTPEKPPHQRAGPFSSRWETTMGEASASIPTTVGS
Sbjct: 970 PRPSSARGSSGSRGGGGSSSSSSELSTPEKPPHQRAGPFSSRWETTMGEASASIPTTVGS 1029
Query: 1081 LPSSKSFLGMKARELFRNKSESQCDEDGMTSSLSESLKTELGKDLGVEAKIPLNLDGPHP 1140
LPSSKSFLGMKARELFRNKSESQCDEDGMTSSLSESLKTELGKDLGVEAKIPLNLDGPHP
Sbjct: 1030 LPSSKSFLGMKARELFRNKSESQCDEDGMTSSLSESLKTELGKDLGVEAKIPLNLDGPHP 1089
Query: 1141 SPPTPDSVGQLHIMDYNETHHEHS 1164
SPPTPDSVGQLHIMDYNETHHEHS
Sbjct: 1090 SPPTPDSVGQLHIMDYNETHHEHS 1113
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 74.3 bits (181), Expect = 6e-13
Identities = 101/400 (25%), Positives = 180/400 (45%), Gaps = 41/400 (10%)
Query: 618 HFVIRKTEELLKKAKGNTEEDGVPSTSPMEVLDRLIQQGADAHSKELNKLP--LPSKSVD 675
H + +TE L +A G +E S+ +++D+ QQ AD K L++L L K +
Sbjct: 420 HSKLLETERQLGEAHGRLKEQRQLSSE--KLMDKE-QQVADLQLK-LSRLEEQLKEKVTN 475
Query: 676 WTHFGGSPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALRN--RRLLRKVIKAAALEEHN 733
T + + Q L Q + + Q+ L R++ K K LE
Sbjct: 476 STELQHQLDKTKQQHQEQQAL---QQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALL 532
Query: 734 AAMKDQLKLQEKDIQMWKVSLQK---EQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFY 790
K+ + L EK+ + +Q E A NQLQE+ T L Q+ QL E+
Sbjct: 533 QKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHT----LQEQVTQLT---EKLK 585
Query: 791 NQSQELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEF--- 847
NQS+ + E+ + + E + L+ A ++V E +++++ +L+ S+ Q++
Sbjct: 586 NQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIK 645
Query: 848 LNRQLLVLGEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQK 907
+LL+ E + H DT + K ++EL K + + Q T +L Q+
Sbjct: 646 AKTELLLSAEAAKTAQRADLQNHLDTAQNALQDK---QQELNKITTQLDQVTAKLQDKQE 702
Query: 908 RILELESHLA--KKDHLLLEQK--------KYLEDVKLQARGQLQAAESRYEAQKRITQV 957
+LESHL K+ +L LEQK K LE L+ + + A + Q+++
Sbjct: 703 HCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTD 762
Query: 958 FELEILDLYGRLEKDGLL---KKLE-EEKAEAAEAAEERL 993
EL +L +LE + + +L+ ++K+EA E+ +++L
Sbjct: 763 LELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKL 802
Score = 68.9 bits (167), Expect = 3e-11
Identities = 77/360 (21%), Positives = 162/360 (45%), Gaps = 36/360 (10%)
Query: 624 TEELLKKAKGNT---EEDGVPSTSPMEVLDRLIQQGADAHSKELNKLPLPSKSVDWTHFG 680
TE LLKK + T E+ S S + L Q+ D + ++L S+ H
Sbjct: 308 TENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQ-SRLSASETSLHRIHVE 366
Query: 681 GSPPSDEIRTLRDQLLLLHN----------QLLYERFKRQQHALRNR----RLLRKVIKA 726
S + + L+++L + QL +R +++QH L+ + +L K+++
Sbjct: 367 LSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLET 426
Query: 727 AA-LEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQLQEQ---RDTMVTKLHSQIRQL 782
L E + +K+Q +L + + + + Q + ++L+EQ + T T+L Q+ +
Sbjct: 427 ERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKT 486
Query: 783 QHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQ 842
+ +E Q KL + +N + ++ ++ + K+ + E LL + + +S E +
Sbjct: 487 KQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKER 546
Query: 843 QQMEFLNRQLLVLGEVNELYLEQLQNKH-------SDTTKEVEMMKAAYRKELEKNRSHV 895
+ + + GE L QLQ K+ + T++++ ++++ E V
Sbjct: 547 EDL----YAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQV 602
Query: 896 LQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQ---LQAAESRYEAQK 952
+Q L +Q R+L LE+ + + + L E K+ + + +Q + + L +AE+ AQ+
Sbjct: 603 QEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQR 662
Score = 53.5 bits (127), Expect = 1e-06
Identities = 80/387 (20%), Positives = 162/387 (41%), Gaps = 33/387 (8%)
Query: 621 IRKTEELLKKAKGNTEEDGVPSTSPMEVLDRLIQQGADAHSKELNKLPLPSKSVDWTHFG 680
++K E L+ K + + + L Q+ H + N++ +
Sbjct: 788 LQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKME 847
Query: 681 GSPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQL 740
E+ T++D+L + + L + + ++ + + + + K +H ++ +
Sbjct: 848 KEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMEN 907
Query: 741 KLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKL---HSQIRQLQHDREEFYNQSQELQ 797
L+E+ + K SL+KE+ +QL+ + ++M +L + ++Q + + ++ EL+
Sbjct: 908 TLKEQ--KELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELK 965
Query: 798 TKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGE 857
E + I L+ ELK A V L +++ Q+L+ + Q++ ++ VL
Sbjct: 966 QSSEQKKKQIEALQGELKIA---VLQKTELENKLQQQLTQAA---QELAAEKEKISVLQN 1019
Query: 858 VNELYLEQLQNKHSD-------------TTKEVEMMKAAYRKELEKNRSHVLQQTQRLDT 904
E E + SD K VE + +++L NR+ + Q + +
Sbjct: 1020 NYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQE 1079
Query: 905 SQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILD 964
+ LE AKK+ L E+ K L+D+ Q L+ E E K EI +
Sbjct: 1080 LKTAKATLEQDSAKKEQQLQERCKALQDI--QKEKSLKEKELVNEKSKL------AEIEE 1131
Query: 965 LYGRLEKDGLLKKLEEEKAEAAEAAEE 991
+ R EK+ + K EE K+ E+ +E
Sbjct: 1132 IKCRQEKE-ITKLNEELKSHKLESIKE 1157
Score = 51.2 bits (121), Expect = 6e-06
Identities = 60/271 (22%), Positives = 121/271 (44%), Gaps = 31/271 (11%)
Query: 741 KLQEKDIQMWKVSLQKEQARYNQLQEQRD----------TMVTKLHSQI----RQLQHDR 786
KL+E ++ + Q +A + QLQ+QR+ + + +LHS++ RQL
Sbjct: 376 KLKE-ELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAH 434
Query: 787 EEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQME 846
Q Q KL D +A+L+++L + ++ +++ +L ++ Q+ +
Sbjct: 435 GRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQ 494
Query: 847 FLNRQLLVLGEVNELYLEQLQNKHSDTTKEVEMMKAAYRKE------LEKNRSHVLQQTQ 900
L + + LEQ+ + D ++++ ++A +K LEK R + + Q
Sbjct: 495 ALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQ 554
Query: 901 RLDTSQKRILELESHLAKKDHLLLEQKKYL-EDVKLQARGQLQAAES---RYEAQKRITQ 956
+ +L + L +K+H L EQ L E +K Q+ QA E+ + + QK +
Sbjct: 555 -AGEGETAVL---NQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLR 610
Query: 957 VFELEILDLYGRLEKDGLLKKLEEEKAEAAE 987
+ +L L + + L +L E K + ++
Sbjct: 611 AAQDRVLSLETSVNE--LNSQLNESKEKVSQ 639
Score = 50.1 bits (118), Expect = 1e-05
Identities = 61/316 (19%), Positives = 140/316 (44%), Gaps = 32/316 (10%)
Query: 687 EIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEKD 746
E+ ++++QL+ N L + QQ L+ I L++ + K Q++ + +
Sbjct: 932 ELNSMQEQLIQAQNTLKQNEKEEQQ--------LQGNINE--LKQSSEQKKKQIEALQGE 981
Query: 747 IQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQ---IRQLQHDREEFYNQSQELQTKLEDC 803
+ K+++ ++ N+LQ+Q +L ++ I LQ++ E+ ++LQ+
Sbjct: 982 L---KIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGR 1038
Query: 804 RNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYL 863
+ + R +LK K+ + L ++ N + Q+++ L E +
Sbjct: 1039 ESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATL----EQDSAKK 1094
Query: 864 EQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLA------ 917
EQ + ++++ K+ KEL +S + + + +K I +L L
Sbjct: 1095 EQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLES 1154
Query: 918 -KKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLLK 976
K+ L + K+ L KL+ +G+ + ++ E +KR Q+ + ++ + E++ L K
Sbjct: 1155 IKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQV-----KKEEEELKK 1209
Query: 977 KLEEEKAEAAEAAEER 992
+ E++A+ +E+
Sbjct: 1210 EFIEKEAKLHSEIKEK 1225
Score = 49.7 bits (117), Expect = 2e-05
Identities = 77/357 (21%), Positives = 158/357 (44%), Gaps = 40/357 (11%)
Query: 618 HFVIRKTEELL--KKAKGNTEEDGVPSTSPME-VLDRLIQQGADAHSKELNKLPLPSKSV 674
+F I++ ++L K A+ TE + S E L +Q ++ELNK + +
Sbjct: 151 NFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDL 210
Query: 675 DWTHFGGSPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNA 734
T P +++ L+ +L+ + + +R++ + + + +K+ A E
Sbjct: 211 K-TELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATI 269
Query: 735 A-MKDQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQS 793
+ ++ +L +++ ++ LQK ++ N+L ++ T+ L +E+ Y
Sbjct: 270 SQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLK--------KEQDY--- 318
Query: 794 QELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLL 853
TKLE+ N E + K + +L Q+ +LS SE+ + ++ +L
Sbjct: 319 ----TKLEEKHN---EESVSKKNIQATLHQKDLDCQQLQSRLSASET---SLHRIHVELS 368
Query: 854 VLGEVNELYLEQLQNKHSDTTKEVEMMKAAYR---KELEKNRSHVLQQTQRLDTSQKRIL 910
GE + E+L S+ + + +KA ++ ++ E+ H LQ ++ ++L
Sbjct: 369 EKGEATQKLKEEL----SEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLL 424
Query: 911 ELESHLAKKDHLLLEQKKYLEDVKLQARGQ----LQAAESRYEAQ--KRITQVFELE 961
E E L + H L++++ L KL + Q LQ SR E Q +++T EL+
Sbjct: 425 ETERQLGEA-HGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQ 480
Score = 47.0 bits (110), Expect = 1e-04
Identities = 60/284 (21%), Positives = 129/284 (45%), Gaps = 23/284 (8%)
Query: 687 EIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEK- 745
+++++ ++L L L+ R +L++++ A A E ++A K+Q +LQE+
Sbjct: 1048 DLKSVEEKLSLAQEDLISNR----NQIGNQNKLIQELKTAKATLEQDSAKKEQ-QLQERC 1102
Query: 746 ----DIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLE 801
DIQ K +KE + + + + +I +L + + +S + T L+
Sbjct: 1103 KALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLK 1162
Query: 802 DCRNMIAELRIELK-KANN--KVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEV 858
D + ++ + ++EL+ KA++ E Q+ + E + + EF+ ++ + E+
Sbjct: 1163 DAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEI 1222
Query: 859 NELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAK 918
E E KH + ++ M A L +N V ++ Q +SQ+R+ ELE
Sbjct: 1223 KE--KEVGMKKHEENEAKLTMQITA----LNENLGTVKKEWQ---SSQRRVSELEKQTDD 1273
Query: 919 KDHLLLEQKKYLEDVKLQARGQLQ-AAESRYEAQKRITQVFELE 961
+ + +++ + + R L+ + E +K T+V EL+
Sbjct: 1274 LRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQ 1317
Score = 45.1 bits (105), Expect = 4e-04
Identities = 74/315 (23%), Positives = 129/315 (40%), Gaps = 67/315 (21%)
Query: 731 EHNAAMK-DQLKLQEKDIQMWKVSLQ----------KEQARYNQLQEQR---DTMVTKLH 776
E N A+K D + L +++Q + SL+ KE +Y LQ+Q D +VT
Sbjct: 75 ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSS 134
Query: 777 SQIRQLQHDREE--------------FYNQSQELQTKLEDCRNMIAELRIELKKANNKVC 822
++++ L+ EE F ++ +L T++ D ++ E R + A KV
Sbjct: 135 AELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVT 194
Query: 823 H----------------TELLLSQVSQKLS--NSESVQQQMEFLNRQLLVLGEVNELYLE 864
TELL + ++ E VQ Q N L E +L E
Sbjct: 195 RLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDE 254
Query: 865 --QLQNKHSDTTKEVEMMK----------AAYRKELEKNRSHVLQQTQRLDTSQKRILEL 912
+LQ++++ + + ++ A Y +EL+K +S V + TQ+ T + +L+
Sbjct: 255 CKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKK 314
Query: 913 ESHLAKKDHLLLEQ---KKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRL 969
E K + E+ KK ++ Q Q +SR A + +E+
Sbjct: 315 EQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVEL------S 368
Query: 970 EKDGLLKKLEEEKAE 984
EK +KL+EE +E
Sbjct: 369 EKGEATQKLKEELSE 383
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 68.2 bits (165), Expect = 4e-11
Identities = 89/392 (22%), Positives = 176/392 (44%), Gaps = 38/392 (9%)
Query: 623 KTEELLKKAKGNTEEDGVPSTSPMEVLDRLIQQGADA-HSKELNKLPLPSKSVDWTHFGG 681
+ +ELL++ KG ++ S ++ + RL+ QG D H E + L +K H G
Sbjct: 405 RLQELLERRKGEAQQ----SNKELQNMKRLLDQGEDLRHGLETQVMELQNKL---KHVQG 457
Query: 682 SPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLLRKVIKA--AALEEHNAAMKDQ 739
P+ E+ L+D LL +LL E + +Q RL + + A AL+E A+ +
Sbjct: 458 PEPAKEV-LLKD--LLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQE 514
Query: 740 LK----LQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQE 795
++ ++D + + S+Q + L+ +R M + R+L+ EE +
Sbjct: 515 VEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSM 574
Query: 796 LQTKLEDCR---NMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQL 852
Q ED R + +LR+E ++ ++ +L + ++ S +Q+E L ++L
Sbjct: 575 FQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKEL 634
Query: 853 L-VLGEVNELYLE----QLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQK 907
L E+ EL E ++ +H D +E+E A R E ++ R Q Q T Q+
Sbjct: 635 LRTQEELKELQAERQSQEVAGRHRD--RELEKQLAVLRVEADRGRELEEQNLQLQKTLQQ 692
Query: 908 RILELE-----SHLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEI 962
+ E +A+ + +L Q++ + L+ + E E ++RI + E ++
Sbjct: 693 LRQDCEEASKAKMVAEAEATVLGQRRAAVETTLR-----ETQEENDEFRRRILGL-EQQL 746
Query: 963 LDLYGRLEKDGLLKKLEEEKAEAAEAAEERLD 994
+ G ++ ++ +K + EA +++L+
Sbjct: 747 KETRGLVDGGEAVEARLRDKLQRLEAEKQQLE 778
Score = 48.9 bits (115), Expect = 3e-05
Identities = 82/325 (25%), Positives = 138/325 (42%), Gaps = 32/325 (9%)
Query: 687 EIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEKD 746
++ L+ +LL +L + +RQ + R R++ K A+ A +L +E++
Sbjct: 626 QVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGREL--EEQN 683
Query: 747 IQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNM 806
+Q+ K +Q R + + + MV + + + L R +E Q + ++ R
Sbjct: 684 LQLQKTL---QQLRQDCEEASKAKMVAEAEATV--LGQRRAAVETTLRETQEENDEFRRR 738
Query: 807 IAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQM-EFLNR------QLLVLGEVN 859
I L +LK+ V E + +++ KL E+ +QQ+ E LN L
Sbjct: 739 ILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRAL 798
Query: 860 ELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKK 919
E LE+ Q + +E + + A E E + VL++ + QKR+L+
Sbjct: 799 EARLEEAQRGLARLGQEQQTLNRAL--EEEGKQREVLRRGKAELEEQKRLLD-----RTV 851
Query: 920 DHLLLEQKKYLEDVKLQARGQLQAAESRY-EAQKRITQVFELEILDLYGRLEK-DGLLKK 977
D L E +K ED K QA QLQA Y E +R + + D EK G L +
Sbjct: 852 DRLNKELEKIGEDSK-QALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSR 910
Query: 978 LEEE--------KAEAAEAAEERLD 994
L++E +A AE RLD
Sbjct: 911 LQDEIQRLRQALQASQAERDTARLD 935
Score = 47.8 bits (112), Expect = 6e-05
Identities = 64/305 (20%), Positives = 126/305 (41%), Gaps = 29/305 (9%)
Query: 717 RRLLRKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLH 776
R+L +V K LE ++ QL+ + ++ + L++ + Q ++ M +L
Sbjct: 373 RKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNM-KRLL 431
Query: 777 SQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLS 836
Q L+H E Q ELQ KL+ + + LK + T LL +V L
Sbjct: 432 DQGEDLRHGLE---TQVMELQNKLKHVQGPEPAKEVLLKD----LLETRELLEEV---LE 481
Query: 837 NSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVL 896
+ V++Q+ R+L L L+ + + +EVE ++ Y+++ E+ R +
Sbjct: 482 GKQRVEEQLRLRERELTALKGA-------LKEEVASRDQEVEHVRQQYQRDTEQLRRSMQ 534
Query: 897 QQTQR---LDTSQKRIL--------ELESHLAKKDHLLLEQKKYLEDVKLQARGQLQAAE 945
TQ L+ ++++ ELE + H +K ED++ + LQ
Sbjct: 535 DATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRM 594
Query: 946 SRYEAQKRITQVFELEILDLYGRLEKDGLLKKLEEEKAEAAEAAEERLDCCNDGCSDSMV 1005
+ E ++ + + E+ +L G +++E K E EE + + S +
Sbjct: 595 EKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVA 654
Query: 1006 GHNEE 1010
G + +
Sbjct: 655 GRHRD 659
Score = 47.0 bits (110), Expect = 1e-04
Identities = 88/374 (23%), Positives = 151/374 (40%), Gaps = 62/374 (16%)
Query: 623 KTEELLKKAKGNTEEDGVPSTSPMEVLDRLIQQGADAHSKELNKLPLPSKSVDWTHFGGS 682
K E+L++ K EE RL+ + D +KEL K+ SK
Sbjct: 828 KQREVLRRGKAELEEQ-----------KRLLDRTVDRLNKELEKIGEDSKQA-------- 868
Query: 683 PPSDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKL 742
++ L+ QL E +K + A R ++ K A E + L
Sbjct: 869 -----LQQLQAQL---------EDYKEK--ARREVADAQRQAKDWASEAEKTS--GGLSR 910
Query: 743 QEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLED 802
+ +IQ + +LQ QA + + ++ + +L L+ + E + +L+
Sbjct: 911 LQDEIQRLRQALQASQAERDTARLDKELLAQRLQG----LEQEAENKKRSQDDRARQLKG 966
Query: 803 CRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQM--EFLNRQLLVLGEVNE 860
++ L EL + N V ELL +V++ + ++ ++ E RQ L E ++
Sbjct: 967 LEEKVSRLETELDEEKNTV---ELLTDRVNRGRDQVDQLRTELMQERSARQDL---ECDK 1020
Query: 861 LYLEQLQNKHSDT---TKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLA 917
+ LE+ QNK T + E +A +LE +++ +LQ+ RL ++ L+S
Sbjct: 1021 ISLER-QNKDLKTRLASSEGFQKPSASLSQLE-SQNQLLQE--RLQAEEREKTVLQSTNR 1076
Query: 918 KKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLLKK 977
K + + E +ED + Q R +A KR E EI L DGL KK
Sbjct: 1077 KLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERL------DGLRKK 1130
Query: 978 LEEEKAEAAEAAEE 991
+ E E E E+
Sbjct: 1131 AQREVEEQHEVNEQ 1144
Score = 37.7 bits (86), Expect = 0.064
Identities = 37/141 (26%), Positives = 62/141 (43%), Gaps = 9/141 (6%)
Query: 652 LIQQGADAHSKELNKLPLPSKSVDW-----THFGGSPPSDEIRTLRDQLLLLHNQLLYER 706
L+Q+ + E +K+ L ++ D + G PS + L Q LL +L E
Sbjct: 1006 LMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEE 1065
Query: 707 FKRQQHALRNRRLLRKV----IKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYN 762
++ NR+L RKV I+ +H KDQL L+ K ++ ++E R +
Sbjct: 1066 REKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLD 1125
Query: 763 QLQEQRDTMVTKLHSQIRQLQ 783
L+++ V + H QLQ
Sbjct: 1126 GLRKKAQREVEEQHEVNEQLQ 1146
>gi|30581135 structural maintenance of chromosomes 1A [Homo sapiens]
Length = 1233
Score = 67.8 bits (164), Expect = 6e-11
Identities = 87/397 (21%), Positives = 180/397 (45%), Gaps = 60/397 (15%)
Query: 640 VPSTSPMEVLDRLIQQGADAHSKELNKLPLPSKSVDWTHFGGSPPSDEIRTLRDQLLLLH 699
V +S ++ ++++Q +S+EL KL + K+ ++ F G+ S ++ +++ L
Sbjct: 99 VGGSSEYKINNKVVQ--LHEYSEELEKLGILIKARNFLVFQGAVESIAMKNPKERTALFE 156
Query: 700 N-----QLLYERFKRQQ-------------HALRNRRLLRKVIKAAALE-EHNAAMKDQL 740
+L E KR++ H +N RK K E + +KD++
Sbjct: 157 EISRSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEADRYQRLKDEV 216
Query: 741 KLQEKDIQMWKV--------SLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQ 792
+ +Q++K+ L KE A N+ E+ + K+ ++++ + + + +
Sbjct: 217 VRAQVQLQLFKLYHNEVEIEKLNKELASKNKEIEKDKKRMDKVEDELKEKKKELGKMMRE 276
Query: 793 SQELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQ----MEFL 848
Q+++ ++++ + + + R + KA H L + L N++ ++ M+ L
Sbjct: 277 QQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDEL 336
Query: 849 NRQLLVLGEVNELYLEQL----QNKHSDTTKEVEMMKAAYR--KELEKNRSHVLQQTQRL 902
+++L + + + + E++ Q++ D T E +K +R +E K + + Q+ ++
Sbjct: 337 EKEMLSVEKARQEFEERMEEESQSQGRDLTLEENQVKKYHRLKEEASKRAATLAQELEKF 396
Query: 903 DTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEI 962
+ QK A +D L LE++K +E + + + +L+ E E QKRI E
Sbjct: 397 NRDQK---------ADQDRLDLEERKKVE-TEAKIKQKLREIE---ENQKRI------EK 437
Query: 963 LDLYGRLEKDGL--LKKLEEEKAEAAEAAEERLDCCN 997
L+ Y K L KKLE E E E A+ R+D N
Sbjct: 438 LEEYITTSKQSLEEQKKLEGELTEEVEMAKRRIDEIN 474
Score = 50.1 bits (118), Expect = 1e-05
Identities = 46/250 (18%), Positives = 118/250 (47%), Gaps = 24/250 (9%)
Query: 737 KDQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQEL 796
K+QLK + + MW+ +++K++ +L+++ + + + QLQ + NQ
Sbjct: 825 KNQLKEDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQ----DLKNQHLAK 880
Query: 797 QTKLEDCRNMIAELRIELKKANNKVCHTE----LLLSQVSQKLSNSESVQQQMEFLNRQL 852
++++ D + + E+R +L AN ++ H + + +++ QK S+ ++ Q + + +L
Sbjct: 881 KSEVNDKNHEMEEIRKKLGGANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKL 940
Query: 853 -LVLGEVNELYLEQLQNKHSDTTKEVEMMKAAYRKEL------------EKNRSHVLQQT 899
L G ++++ E+ ++ D+ + + + Y +E K+ +
Sbjct: 941 PLSKGTMDDISQEEGSSQGEDSVSGSQRISSIYAREALIEIDYGDLCEDLKDAQAEEEIK 1000
Query: 900 QRLDTSQKRILELES---HLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQ 956
Q ++T Q+++ E +S +A + +E+ + + D + + +AA R + K+ +
Sbjct: 1001 QEMNTLQQKLNEQQSVLQRIAAPNMKAMEKLESVRDKFQETSDEFEAARKRAKKAKQAFE 1060
Query: 957 VFELEILDLY 966
+ E D +
Sbjct: 1061 QIKKERFDRF 1070
Score = 31.2 bits (69), Expect = 6.0
Identities = 44/156 (28%), Positives = 75/156 (48%), Gaps = 33/156 (21%)
Query: 859 NELYLEQLQNKHSDTTKEVEMMKAAYRKELE----KNRSHVLQQTQRLDTSQKRILELES 914
+E +++L+ K T+E++ A RKE E ++++H LQ RL SQ + + ++
Sbjct: 667 DEKAVDKLKEKKERLTEELKEQMKAKRKEAELRQVQSQAHGLQ--MRLKYSQSDLEQTKT 724
Query: 915 -HLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRLE--K 971
HLA L L++K LE +L R KRI Q E E+ DL ++ +
Sbjct: 725 RHLA----LNLQEKSKLE-------SELANFGPRINDIKRIIQSREREMKDLKEKMNQVE 773
Query: 972 DGL------------LKKLEEEKAEAA-EAAEERLD 994
D + +++ EEEK + E A++RL+
Sbjct: 774 DEVFEEFCREIGVRNIREFEEEKVKRQNEIAKKRLE 809
>gi|46592991 GRIP1 associated protein 1 isoform 1 [Homo sapiens]
Length = 841
Score = 63.5 bits (153), Expect = 1e-09
Identities = 75/310 (24%), Positives = 133/310 (42%), Gaps = 40/310 (12%)
Query: 688 IRTLRDQLLL--LHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEK 745
+R L+DQ+ + Q E + +ALR AALE+ A +L + +
Sbjct: 310 LRALQDQVSIQSADAQEQVEGLLAENNALRT--------SLAALEQIQTAKTQELNMLRE 361
Query: 746 DIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRN 805
LQ++QA Y L Q+D L+SQ+++ Q QE+ + E
Sbjct: 362 QTTGLAAELQQQQAEYEDLMGQKD----DLNSQLQESLRANSRLLEQLQEIGQEKEQLTQ 417
Query: 806 MIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQ 865
+ E R +K K EL + + +K + E + L + VLG V Y +
Sbjct: 418 ELQEARKSAEK--RKAMLDELAMETLQEKSQHKEELGAVR--LRHEKEVLG-VRARYERE 472
Query: 866 LQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLE 925
L+ H D ++ E ++ R+E + T+ L+T Q+ + EL++ + H +
Sbjct: 473 LRELHEDKKRQEEELRGQIREEKAR--------TRELETLQQTVEELQAQV----HSMDG 520
Query: 926 QKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLLKKLEEEKAEA 985
K + E +A LQ + + E ++ + Q E +L G+ E +L++ + +
Sbjct: 521 AKGWFERRLKEAEESLQ--QQQQEQEEALKQCREQHAAELKGKEE------ELQDVRDQL 572
Query: 986 AEAAEERLDC 995
+A EER DC
Sbjct: 573 EQAQEER-DC 581
Score = 60.1 bits (144), Expect = 1e-08
Identities = 77/329 (23%), Positives = 142/329 (43%), Gaps = 38/329 (11%)
Query: 681 GSPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQL 740
G PP T+ + L +L +E K ++ L + + ++++ E + ++
Sbjct: 173 GDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQL---QGLESSKQAETSRLQEELA 229
Query: 741 KLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYN----QSQEL 796
KL EK L+K+Q + +LQ +++T+ ++I +LQ +E + ++Q+L
Sbjct: 230 KLSEK--------LKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKL 281
Query: 797 QTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQME-------FLN 849
Q +LE +AELR + + ++ H L + Q S Q+Q+E L
Sbjct: 282 QQELEAANQSLAELRDQ--RQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALR 339
Query: 850 RQLLVLGEVNELYLEQLQNKHSDTT---KEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQ 906
L L ++ ++L TT E++ +A Y ++L + + Q Q +
Sbjct: 340 TSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEY-EDLMGQKDDLNSQLQESLRAN 398
Query: 907 KRILE-LESHLAKKDHL---LLEQKKYLEDVKLQ----ARGQLQAAESRYEAQKRITQVF 958
R+LE L+ +K+ L L E +K E K A LQ E +
Sbjct: 399 SRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRH 458
Query: 959 ELEILDLYGRLEKDGLLKKLEEEKAEAAE 987
E E+L + R E++ L++L E+K E
Sbjct: 459 EKEVLGVRARYERE--LRELHEDKKRQEE 485
>gi|210032790 hypothetical protein LOC27146 [Homo sapiens]
Length = 1060
Score = 63.2 bits (152), Expect = 1e-09
Identities = 76/330 (23%), Positives = 150/330 (45%), Gaps = 36/330 (10%)
Query: 669 LPSKSVDWTHFGGSPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLLRKVIKAAA 728
LP +S + G P + L Q L + NQ L + + R+ L+ A
Sbjct: 176 LPQESPETKSEPGQGPEMQEVLLEVQRLRVENQQLSKDYARKAEELQ-----------AT 224
Query: 729 LEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYN-QLQEQRDTMVTKLHSQIRQLQHDRE 787
E N A++ ++ Q +W+ ++ R N Q+QE + L +Q+R+L+ D E
Sbjct: 225 YERENEAIRQAMQ-QSVSQALWQWQEKESDLRKNFQVQE------SALQAQVRKLEGDLE 277
Query: 788 EFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQ----- 842
+ +L+ + + I +L ++LK+A + + ++ +KL+ ++
Sbjct: 278 HRGRKISDLKKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAKDRMMLQEC 337
Query: 843 ---QQMEFLNRQLL----VLGEVNELYLEQLQNKHSDT-TKEVEMMKAAYRKELEKNRSH 894
QQ + + +L+ VL E N+L L + + KE MK + +K S
Sbjct: 338 RGTQQTDAMKTELVSENKVLREENDLEAGNLHPQQDQSCLKECPCMKGGTDMQTKKEASA 397
Query: 895 VLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQ-KR 953
+ ++ R ++ ++ KK HL + K LED+ + ++++ S EA+ K+
Sbjct: 398 ETEYMKQQYEEDLRKIKHQTEEEKK-HLKDQLVKRLEDLVKKHTVEIKSVRSSVEAERKK 456
Query: 954 ITQVFELEILDLYGRLEKDGLLKKLEEEKA 983
+ + E ++ ++ + EK+ +K+LEEEKA
Sbjct: 457 LQREVEAQLEEVRKKSEKE--IKQLEEEKA 484
Score = 44.7 bits (104), Expect = 5e-04
Identities = 90/402 (22%), Positives = 163/402 (40%), Gaps = 67/402 (16%)
Query: 686 DEIRTLRDQLL-----LLHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQL 740
+E + L+DQL+ L+ + + R ++L R+V A LEE + ++
Sbjct: 419 EEKKHLKDQLVKRLEDLVKKHTVEIKSVRSSVEAERKKLQREV--EAQLEEVRKKSEKEI 476
Query: 741 KLQEKDIQMWKVSLQK---EQARYNQLQEQRDTMVTKLHSQIRQL--QH----------- 784
K E++ V LQ E R + +Q T T ++L QH
Sbjct: 477 KQLEEEKAALNVKLQNSLLEVLRLEEFIQQNKTRPTGAEESPQELGRQHCSILETQDPCL 536
Query: 785 DREEFYNQSQELQTKL-----------EDCRNMIAE-------LRIELKKANNKVCHTE- 825
+E + +E Q KL E + ++ E L LK+ +K+ E
Sbjct: 537 KLDETSPRGEEYQDKLAAEEGTSSDEEERTKVLLKEGSDPQPPLGSLLKEKTSKIQRLEE 596
Query: 826 -------LLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVE 878
L +QVSQ ++++Q L L ++++L E+LQ + +TT++
Sbjct: 597 DWQSQKAKLQAQVSQM---QQALEQCTSNYREDLQALKQLSDLEREKLQRELQETTQQNH 653
Query: 879 MMKAAYRKELEKNRSHVLQ-----QTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDV 933
MKA +LE + L+ + Q L +++R+ + SH + H + L+ +
Sbjct: 654 AMKA----QLEASHQRALRMLEKARHQELKATEERLKKESSHSLQIQH--QTHRLELQAL 707
Query: 934 KLQARGQLQAAESRYEAQKR-ITQVFELEILDLYGRLEKDGLLKKLEEEKAEAAEAAEER 992
+ +AR +LQ R +AQ+ + + E+ + G K LE +AE ++
Sbjct: 708 EEKARQELQEERERMQAQQALLLESLRQELSEQQAAC--SGHQKDLEALQAELRALGRQQ 765
Query: 993 LDCCNDGCSDSMVGHNEEASGHNGETKTPRPSSARGSSGSRG 1034
G S + EE G G+ +P ++ +GS G
Sbjct: 766 ASSQCPGDSKDHIIATEERGG-PGQAGSPPGAAGQGSGEGCG 806
Score = 40.8 bits (94), Expect = 0.008
Identities = 63/241 (26%), Positives = 100/241 (41%), Gaps = 45/241 (18%)
Query: 701 QLLYERFKRQQHALRNRRLLRKVIKAAA--LEEHNAAMKDQLKLQEKDIQMWKVSLQKEQ 758
Q L ER + L+ R +K A L E A KD++ LQE
Sbjct: 291 QKLKERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAKDRMMLQE-------------- 336
Query: 759 ARYNQLQEQRDTMVTKLHSQIRQL--QHDREEFYNQSQELQTKLEDCRNMIAELRIELKK 816
R Q Q D M T+L S+ + L ++D E Q+ Q+ L++C M ++ KK
Sbjct: 337 CRGTQ---QTDAMKTELVSENKVLREENDLEAGNLHPQQDQSCLKECPCMKGGTDMQTKK 393
Query: 817 ANNKVCHTELLLSQVSQKLSN-SESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTK 875
+ TE + Q + L +++ + L QL+ LE L KH+ K
Sbjct: 394 EAS--AETEYMKQQYEEDLRKIKHQTEEEKKHLKDQLVKR-------LEDLVKKHTVEIK 444
Query: 876 EVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKL 935
V A RK+L++ L++ ++ S+K I +LE ++K +VKL
Sbjct: 445 SVRSSVEAERKKLQREVEAQLEEVRK--KSEKEIKQLE------------EEKAALNVKL 490
Query: 936 Q 936
Q
Sbjct: 491 Q 491
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 61.6 bits (148), Expect = 4e-09
Identities = 80/412 (19%), Positives = 183/412 (44%), Gaps = 45/412 (10%)
Query: 602 PPYDHLFEVALPKTAHHFVIRKTEELLKKAKGNTE-EDGVPSTSPMEVLDRLIQQGADAH 660
P + HL P H ++ K K A+ + D P T+P + +D
Sbjct: 34 PTHPHL--PTHPHLPTHPMMSKETRQSKLAEAKEQLTDHHPQTNPS-----VGTAASDTK 86
Query: 661 SKELNKLPLPSKSVDWTHFGGSPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLL 720
K++N P + T G P DE + H + L + Q H +R
Sbjct: 87 KKKINNGTNPETT---TSGGCHSPEDEQKASHQ-----HQEALRRELEAQVHTIRILTCQ 138
Query: 721 RKVIKAAALEEHNAAMKDQLKLQEKDI-----QMWKVSLQKEQA------------RY-N 762
+ ++ A +A QL+ + +D+ WK + + EQA RY
Sbjct: 139 KTELQMALYYSQHAVK--QLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIE 196
Query: 763 QLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVC 822
+L ++RD + +L+ R D EE ++ +LQ KL+ + +E+++ +K+ K+
Sbjct: 197 ELTKERDALSLELY---RNTITD-EELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLE 252
Query: 823 HTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVEMMKA 882
+LLL Q Q + ++ + ++++ ++ +L E NEL+ Q + ++ E ++
Sbjct: 253 RAKLLLPQ-QQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQ- 310
Query: 883 AYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQLQ 942
+ +++++ + +Q +++ ++++ E + +K+ + Q++ + + + + R Q +
Sbjct: 311 EWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEE 370
Query: 943 AAESRYEAQKRITQVF---ELEILDLYGRLEKDGLLKKLEEEKAEAAEAAEE 991
+ E +R ++ E +I +L ++ + +++ EE++ E + E+
Sbjct: 371 MMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQ 422
Score = 55.5 bits (132), Expect = 3e-07
Identities = 54/316 (17%), Positives = 141/316 (44%), Gaps = 27/316 (8%)
Query: 686 DEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEK 745
+E+ +++ + ++++E+ ++ + K+ + + +++Q K QE+
Sbjct: 369 EEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQ 428
Query: 746 DIQMWKVSLQKEQARYNQLQEQRDTM---VTKLHSQIR----QLQHDREEFYNQSQELQT 798
+ +MW+ +K + + +++EQ M K+H Q + + + ++EE + Q +++
Sbjct: 429 EAKMWRQE-EKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHE 487
Query: 799 KLEDCRNM--IAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLG 856
+ E R + E +++K KV E + + +K+ E + E R+ +
Sbjct: 488 QEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMW 547
Query: 857 EVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHL 916
E EQ + + +E E +++ + V +Q +++ +++ E E +
Sbjct: 548 REEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKM 607
Query: 917 AKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLLK 976
K++ + EQ++ +++ + + R Q E + Q+ +TQ E++ +
Sbjct: 608 WKQEEKIREQEEKIQEQEEKIREQ----EEKIREQEEMTQ-------------EQEEKMG 650
Query: 977 KLEEEKAEAAEAAEER 992
+ EE+ E E +E+
Sbjct: 651 EQEEKMCEQEEKMQEQ 666
Score = 51.6 bits (122), Expect = 4e-06
Identities = 38/225 (16%), Positives = 97/225 (43%), Gaps = 31/225 (13%)
Query: 733 NAAMKDQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQ 792
N ++++ QE+ IQ W+ +Q+++ + + +E+ K+ Q + E+ Q
Sbjct: 295 NQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQ 354
Query: 793 SQELQTKLEDCR---NMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLN 849
+ + K E R M+ E ++++ + E + ++ +K+ E +++Q E
Sbjct: 355 EEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEE--- 411
Query: 850 RQLLVLGEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRI 909
K E K +++ ++ + + +Q +++ +++I
Sbjct: 412 -------------------------KRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKI 446
Query: 910 LELESHLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRI 954
E E + +++ + EQ+K E+ K Q + ++ E + Q+ I
Sbjct: 447 REQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEI 491
Score = 47.8 bits (112), Expect = 6e-05
Identities = 51/273 (18%), Positives = 124/273 (45%), Gaps = 27/273 (9%)
Query: 698 LHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKE 757
+H Q R K + H + +RK + +E +++ K++E++ +MW+ Q+E
Sbjct: 485 IHEQEEIWRQKEKMHEQEEK--IRKQEEKVWRQEEKIREQEE-KIREQEEKMWR---QEE 538
Query: 758 QARYNQLQEQRDTMVTKLHSQIR-----QLQHDREEFYNQSQELQTKLEDCRNMIAELRI 812
+ R QE+ K+H Q + + Q ++ + Q ++++ + E ++R
Sbjct: 539 KIRE---QEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIRE 595
Query: 813 ELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSD 872
+ +K + E + Q + E +Q+Q E + Q + E E+ EQ +
Sbjct: 596 QEEKRQEQ---EEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQ 652
Query: 873 TTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYL-- 930
K E +++++ + +Q +++ +K+I E E + +++ ++ EQ++ +
Sbjct: 653 EEKMCEQ-----EEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWE 707
Query: 931 -EDVKLQARGQLQAAESRYEAQKRITQVFELEI 962
E+ + ++Q E + Q+ +++E E+
Sbjct: 708 QEEKMCEQEEKMQEQEEKMRRQEE--KMWEQEV 738
Score = 44.7 bits (104), Expect = 5e-04
Identities = 46/300 (15%), Positives = 134/300 (44%), Gaps = 15/300 (5%)
Query: 705 ERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQL 764
E+ + Q+ +R + + + + + + K++ ++ MW+ +++ R ++
Sbjct: 328 EKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEK--EEKMRRQEEM 385
Query: 765 QEQRDTMVTKLHSQIRQLQHDREEFYNQSQEL----QTKLEDCRNMIAELRIELKKANNK 820
+++ + +L ++ + + RE+ + +E Q K ++ + ++++ K
Sbjct: 386 MWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEK 445
Query: 821 VCHTELLLSQVSQKLSNSESV-----QQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTK 875
+ E + + +K+ E + +Q+ E + RQ + E E++ Q + H K
Sbjct: 446 IREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIW-RQKEKMHEQEEK 504
Query: 876 EVEMMKAAYRKE--LEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDV 933
+ + +R+E + + + +Q +++ +++I E E +++ + ++K + E+
Sbjct: 505 IRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEK 564
Query: 934 KLQARGQLQAAESRYEAQKRITQVFELEILDL-YGRLEKDGLLKKLEEEKAEAAEAAEER 992
+ + ++ E + Q+ E +I + R E++ + K EE+ E E +E+
Sbjct: 565 RQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQ 624
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 61.6 bits (148), Expect = 4e-09
Identities = 68/326 (20%), Positives = 143/326 (43%), Gaps = 31/326 (9%)
Query: 682 SPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALR----NRRLLRKVIKAAALEEHNAAMK 737
S E++ LR QL Q+ + ++ + + R L + +K L+E+ + +
Sbjct: 738 SEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVS 797
Query: 738 DQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQ 797
+ EK++Q+ K + +Q V KLH + E+F S +L+
Sbjct: 798 QVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQK-------EEQFNMLSSDLE 850
Query: 798 TKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGE 857
E+ +M A+ R + ++ + E L + +++ + S Q+ +N +L
Sbjct: 851 KLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDEL----R 906
Query: 858 VNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLA 917
+ E +E+LQ K + + ++ + K + ++ + +K + S L
Sbjct: 907 LKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLE 966
Query: 918 KKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRL-----EKD 972
KK + + + +L+AR + +E++ + ++ I Q + +LD +L E
Sbjct: 967 KK-----METSHNQCQELKARYERATSETKTKHEE-ILQNLQKTLLDTEDKLKGAREENS 1020
Query: 973 GLLKKLEE-----EKAEAAEAAEERL 993
GLL++LEE +KA+AA+ AE+ +
Sbjct: 1021 GLLQELEELRKQADKAKAAQTAEDAM 1046
Score = 60.1 bits (144), Expect = 1e-08
Identities = 65/318 (20%), Positives = 139/318 (43%), Gaps = 24/318 (7%)
Query: 685 SDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAA----MKDQL 740
S ++ LR+ L + + + + +Q +L + + + N++ M D+L
Sbjct: 846 SSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDEL 905
Query: 741 KLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQ----IRQLQHDREEFYNQSQEL 796
+L+E+D++ ++ L K + LQ+ + M K ++ + +++E + +L
Sbjct: 906 RLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDL 965
Query: 797 QTKLEDCRNMIAELRIELKKANN--KVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLV 854
+ K+E N EL+ ++A + K H E+L + L + ++ E +
Sbjct: 966 EKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGARE---ENSGL 1022
Query: 855 LGEVNELYLEQLQNKHSDTTKEVEMMKAAYRKE-------LEKNRSHVLQQTQRLDTSQK 907
L E+ EL + + K + T ++ + KE LE + + LDT ++
Sbjct: 1023 LQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKE 1082
Query: 908 RILELESHLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYG 967
L+ L K LL + + +E+ + + QAA + + Q Q +++ + G
Sbjct: 1083 NNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQ-QLSALQEENVKLAEELG 1141
Query: 968 RLEKDGLL--KKLEEEKA 983
R +D + +KLEEE++
Sbjct: 1142 R-SRDEVTSHQKLEEERS 1158
Score = 43.9 bits (102), Expect = 9e-04
Identities = 63/319 (19%), Positives = 130/319 (40%), Gaps = 44/319 (13%)
Query: 711 QHALRNRRLLRKVIKAAALEEHNAAMKDQLK-LQEKDIQMWKVSLQKEQARYNQLQEQRD 769
QH + N + + +AA +E A +K ++EK+ + + + ++A L E D
Sbjct: 625 QHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMED 684
Query: 770 TMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHTELLLS 829
T+ ++I+ + + LQ K + +I +LK K+ + L
Sbjct: 685 TLNKLQEAEIK---------VKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRK 735
Query: 830 QVSQKLSNSESVQQQMEFLNRQLLVLG-----------------EVNELYLEQLQNKHSD 872
S+ S + ++QQ+E +Q+ L + EL L LQ +
Sbjct: 736 ASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQ----E 791
Query: 873 TTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHL-------LLE 925
EV +K KEL+ + + ++ + Q+ + E + L +K+ L +
Sbjct: 792 NLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEK 851
Query: 926 QKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLLKKLEEE---K 982
++ L D++ + R + + E +A++++ EI+ + G + L K+ +E K
Sbjct: 852 LRENLADMEAKFREKDEREEQLIKAKEKLENDI-AEIMKMSG--DNSSQLTKMNDELRLK 908
Query: 983 AEAAEAAEERLDCCNDGCS 1001
E + +L N+ S
Sbjct: 909 ERDVEELQLKLTKANENAS 927
Score = 32.0 bits (71), Expect = 3.5
Identities = 44/228 (19%), Positives = 94/228 (41%), Gaps = 20/228 (8%)
Query: 794 QELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLL 853
+ L+ K + ++AE +E + H + +++ + ++E QL
Sbjct: 355 EALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLR 414
Query: 854 VLGEVNELYLEQLQNKHSDTTKEVEMMKAAYRKE-LEKNRSHVLQQTQRLDTSQKRILEL 912
+ E + +L N+ + ++VE ++ +E + K V +++ RI+EL
Sbjct: 415 TMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEK-----SRIMEL 469
Query: 913 ESHLAKKDHLLLEQKKYLE--------DVKLQARGQLQAAESRYEAQKRITQVFELEILD 964
E LA + + E ++ LE D+ L ++ + + + E + Q EI
Sbjct: 470 EKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQ---REITS 526
Query: 965 LYGRLEKDGLLKKLEEEKAEAAEAAEERLDCCNDGCSDSMVGHNEEAS 1012
L E G ++ +++ +A A E+L N+ + N+E S
Sbjct: 527 L---KEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENS 571
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 61.6 bits (148), Expect = 4e-09
Identities = 68/326 (20%), Positives = 143/326 (43%), Gaps = 31/326 (9%)
Query: 682 SPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALR----NRRLLRKVIKAAALEEHNAAMK 737
S E++ LR QL Q+ + ++ + + R L + +K L+E+ + +
Sbjct: 773 SEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVS 832
Query: 738 DQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQ 797
+ EK++Q+ K + +Q V KLH + E+F S +L+
Sbjct: 833 QVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQK-------EEQFNMLSSDLE 885
Query: 798 TKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGE 857
E+ +M A+ R + ++ + E L + +++ + S Q+ +N +L
Sbjct: 886 KLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDEL----R 941
Query: 858 VNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLA 917
+ E +E+LQ K + + ++ + K + ++ + +K + S L
Sbjct: 942 LKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLE 1001
Query: 918 KKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRL-----EKD 972
KK + + + +L+AR + +E++ + ++ I Q + +LD +L E
Sbjct: 1002 KK-----METSHNQCQELKARYERATSETKTKHEE-ILQNLQKTLLDTEDKLKGAREENS 1055
Query: 973 GLLKKLEE-----EKAEAAEAAEERL 993
GLL++LEE +KA+AA+ AE+ +
Sbjct: 1056 GLLQELEELRKQADKAKAAQTAEDAM 1081
Score = 60.1 bits (144), Expect = 1e-08
Identities = 65/318 (20%), Positives = 139/318 (43%), Gaps = 24/318 (7%)
Query: 685 SDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAA----MKDQL 740
S ++ LR+ L + + + + +Q +L + + + N++ M D+L
Sbjct: 881 SSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDEL 940
Query: 741 KLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQ----IRQLQHDREEFYNQSQEL 796
+L+E+D++ ++ L K + LQ+ + M K ++ + +++E + +L
Sbjct: 941 RLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDL 1000
Query: 797 QTKLEDCRNMIAELRIELKKANN--KVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLV 854
+ K+E N EL+ ++A + K H E+L + L + ++ E +
Sbjct: 1001 EKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGARE---ENSGL 1057
Query: 855 LGEVNELYLEQLQNKHSDTTKEVEMMKAAYRKE-------LEKNRSHVLQQTQRLDTSQK 907
L E+ EL + + K + T ++ + KE LE + + LDT ++
Sbjct: 1058 LQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKE 1117
Query: 908 RILELESHLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYG 967
L+ L K LL + + +E+ + + QAA + + Q Q +++ + G
Sbjct: 1118 NNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQ-QLSALQEENVKLAEELG 1176
Query: 968 RLEKDGLL--KKLEEEKA 983
R +D + +KLEEE++
Sbjct: 1177 R-SRDEVTSHQKLEEERS 1193
Score = 43.9 bits (102), Expect = 9e-04
Identities = 63/319 (19%), Positives = 130/319 (40%), Gaps = 44/319 (13%)
Query: 711 QHALRNRRLLRKVIKAAALEEHNAAMKDQLK-LQEKDIQMWKVSLQKEQARYNQLQEQRD 769
QH + N + + +AA +E A +K ++EK+ + + + ++A L E D
Sbjct: 660 QHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMED 719
Query: 770 TMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHTELLLS 829
T+ ++I+ + + LQ K + +I +LK K+ + L
Sbjct: 720 TLNKLQEAEIK---------VKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRK 770
Query: 830 QVSQKLSNSESVQQQMEFLNRQLLVLG-----------------EVNELYLEQLQNKHSD 872
S+ S + ++QQ+E +Q+ L + EL L LQ +
Sbjct: 771 ASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQ----E 826
Query: 873 TTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHL-------LLE 925
EV +K KEL+ + + ++ + Q+ + E + L +K+ L +
Sbjct: 827 NLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEK 886
Query: 926 QKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLLKKLEEE---K 982
++ L D++ + R + + E +A++++ EI+ + G + L K+ +E K
Sbjct: 887 LRENLADMEAKFREKDEREEQLIKAKEKLENDI-AEIMKMSG--DNSSQLTKMNDELRLK 943
Query: 983 AEAAEAAEERLDCCNDGCS 1001
E + +L N+ S
Sbjct: 944 ERDVEELQLKLTKANENAS 962
Score = 39.7 bits (91), Expect = 0.017
Identities = 82/391 (20%), Positives = 150/391 (38%), Gaps = 83/391 (21%)
Query: 639 GVPSTSPMEVLDRLIQQGADAHSKELNKLPLPSKSVDWTHFGGSPPSDEIRTLRDQLLLL 698
G PST+P + +++ S L + P S + S S RT
Sbjct: 282 GFPSTTPAKAKANAVRRVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRT-------- 333
Query: 699 HNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQ 758
LL E + R RK+ AL+E +L+++Q
Sbjct: 334 --GLLTET---------SSRYARKISGTTALQE---------------------ALKEKQ 361
Query: 759 ARYNQLQEQRD---TMVTKLHSQIRQLQHD----REEFYNQSQELQTKLEDCRNMIAELR 811
QL +RD V K S + +++ + R+ EL+ K++ R M+
Sbjct: 362 QHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAAD 421
Query: 812 IELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVN-ELYLEQLQNKH 870
E + LL+Q+ ++ E +Q ++E + + G++ + LE + K
Sbjct: 422 REKVE----------LLNQLEEEKRKVEDLQFRVE---EESITKGDLETQTKLEHARIKE 468
Query: 871 SDTTKEVEMMKA-AYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKY 929
+ + E KA ++ELE R + + + RI+ELE LA + + E ++
Sbjct: 469 LEQSLLFEKTKADKLQRELEDTRVATVSE-------KSRIMELEKDLALRVQEVAELRRR 521
Query: 930 LE--------DVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLLKKLEEE 981
LE D+ L ++ + + + E + Q EI L E G ++ ++
Sbjct: 522 LESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQ---REITSL---KEHFGAREETHQK 575
Query: 982 KAEAAEAAEERLDCCNDGCSDSMVGHNEEAS 1012
+ +A A E+L N+ + N+E S
Sbjct: 576 EIKALYTATEKLSKENESLKSKLEHANKENS 606
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 61.6 bits (148), Expect = 4e-09
Identities = 105/469 (22%), Positives = 199/469 (42%), Gaps = 46/469 (9%)
Query: 622 RKTEELLKKAKGNTEEDGVPSTSPME-VLDRLIQQGADAHSKELNKLPLPSKSVDWTHFG 680
R EE L+ AK E + ME ++ G + H E +K L + V+
Sbjct: 1490 RALEEALE-AKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRAL-EQQVEEMRTQ 1547
Query: 681 GSPPSDEIRTLRDQLLLL--HNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKD 738
DE++ D L L + Q + +F+R + +K + + E A ++D
Sbjct: 1548 LEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELED 1607
Query: 739 QLKLQEKDIQMWK---VSLQKEQARYNQLQEQRDTMVT---KLHSQIRQLQHD------- 785
+ K + + K + L+ +A+ + RD ++ KL +Q++ Q +
Sbjct: 1608 ERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARAS 1667
Query: 786 REEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSES----- 840
R+E + QS+E + KL+ I +L+ EL + H E +++ +++NS S
Sbjct: 1668 RDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSAL 1727
Query: 841 --VQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVEMMKA--AYRKELEKNRSHVL 896
++++E QL E + +E L ++ TT +V+ + A A + + +
Sbjct: 1728 LDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNAR 1787
Query: 897 QQTQRLDTSQK-RILELESHLAKKDHL---LLEQK--KYLEDVKLQARGQLQAAESRYEA 950
QQ +R + K ++ ELE + K LE K + E ++ +A+ + A +
Sbjct: 1788 QQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRT 1847
Query: 951 QKRITQVF-----ELEILDLY-GRLEK-DGLLKKLE------EEKAEAAEAAEERLDCCN 997
+K++ ++F E D Y ++EK + +K+L+ EE+A A A+ +L
Sbjct: 1848 EKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQREL 1907
Query: 998 DGCSDSMVGHNEEASGHNGETKTPRPSSARGSSGSRGGGGSSSSSSELS 1046
D +++ G + E S + P S S R +S ELS
Sbjct: 1908 DDATEANEGLSREVSTLKNRLRRGGPISFSSSRSGRRQLHLEGASLELS 1956
Score = 57.8 bits (138), Expect = 6e-08
Identities = 67/339 (19%), Positives = 146/339 (43%), Gaps = 42/339 (12%)
Query: 692 RDQLLLLHNQLLYERFKRQQHALRNRRLLRKVI--KAAALEEHNAAMKDQLKLQEKDIQM 749
+ Q LL +L E+ + + +R + K LEE ++ +++ +E+ Q+
Sbjct: 881 KHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQI 940
Query: 750 WKVSLQKEQARYNQLQEQRD-----------------TMVTKLHSQIRQLQHDREEFYNQ 792
+ +K QA L+EQ D + K+ +I L+ +F +
Sbjct: 941 LQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKE 1000
Query: 793 SQELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQL 852
+ ++ ++ +C + +AE + K E+++S + ++L E +Q++E R+L
Sbjct: 1001 KKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKL 1060
Query: 853 LVLGEVNEL--YLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRIL 910
GE +L + +LQ + E+++ A +EL+ + +T + + K +
Sbjct: 1061 --DGETTDLQDQIAELQAQ----IDELKLQLAKKEEELQGALARGDDETLHKNNALKVVR 1114
Query: 911 ELESHLAKKDHLLLEQKKYLEDVKLQARG---QLQAAESRYE-------AQKRITQVFEL 960
EL++ +A+ +K + Q R +L+A ++ E AQ+ + E
Sbjct: 1115 ELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQ 1174
Query: 961 EILDLYGRLEK-----DGLLKKLEEEKAEAAEAAEERLD 994
E+ +L LE+ + ++ + + A A E E+L+
Sbjct: 1175 EVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLE 1213
Score = 57.4 bits (137), Expect = 8e-08
Identities = 74/340 (21%), Positives = 145/340 (42%), Gaps = 41/340 (12%)
Query: 687 EIRTLRDQLLLLHNQLLYERFK---------RQQHALRNRRLLRKVIKAAALEEHNAAMK 737
E+RT R+Q + + L E K RQ+HA L ++ +A + + K
Sbjct: 1167 ELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNK 1226
Query: 738 DQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQ 797
L+ K++ LQ+ +A +++ D V +LH+++ + R E ++ +LQ
Sbjct: 1227 QGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQ 1286
Query: 798 TKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGE 857
+L++ ++ E + K E L + L E +Q++ +R + E
Sbjct: 1287 NELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELL--QEETRQKLNLSSRIRQLEEE 1344
Query: 858 VNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHV---LQQTQRLDTSQKRILELES 914
N L++ Q + + K +E A + +L + V L + L+ ++K++L+
Sbjct: 1345 KNS--LQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAE 1402
Query: 915 HLAKKDHLLLEQK---------------KYLEDVKLQARGQLQAAESRYEAQKRITQVF- 958
L+++ LE+K + L+D+ + Q Q A + + QK+ Q+
Sbjct: 1403 ALSQR----LEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLA 1458
Query: 959 -ELEILDLYGRLEKDGLLKKLEEEKAEA---AEAAEERLD 994
E I Y E+D + E++ +A A A EE L+
Sbjct: 1459 EEKSISARYAE-ERDRAEAEAREKETKALSLARALEEALE 1497
Score = 48.5 bits (114), Expect = 4e-05
Identities = 72/332 (21%), Positives = 146/332 (43%), Gaps = 39/332 (11%)
Query: 686 DEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLLRKVIKAAA----LEEHNAAMKDQLK 741
+E + ++ + L QL E RQ+ L K+ K LE+ N+ + K
Sbjct: 943 NEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKK 1002
Query: 742 LQEKDIQMWKVSLQKEQARYNQL---QEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQT 798
L E I L +E+ + L + +++ M++ L ++++ + R+E ++L
Sbjct: 1003 LMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDG 1062
Query: 799 KLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEV 858
+ D ++ IAEL+ ++ + ++ E L Q + + E++ + N L V+ E
Sbjct: 1063 ETTDLQDQIAELQAQIDELKLQLAKKEEEL-QGALARGDDETLHK-----NNALKVVRE- 1115
Query: 859 NELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILEL----ES 914
LQ + ++ ++ E KA+ R + EK + + ++ + L T + L+ +
Sbjct: 1116 -------LQAQIAELQEDFESEKAS-RNKAEKQKRDLSEELEALKTELEDTLDTTAAQQE 1167
Query: 915 HLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRY-----EAQKRITQV--FELEILDLYG 967
K++ + E KK LE+ Q+Q R+ E +++ Q F+ +
Sbjct: 1168 LRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQ 1227
Query: 968 RLEKDGL-----LKKLEEEKAEAAEAAEERLD 994
LE D +K L++ KAE +E ++LD
Sbjct: 1228 GLETDNKELACEVKVLQQVKAE-SEHKRKKLD 1258
Score = 46.2 bits (108), Expect = 2e-04
Identities = 81/399 (20%), Positives = 161/399 (40%), Gaps = 59/399 (14%)
Query: 637 EDGVPSTSPMEVLDRLIQQGADAHSKELNKLPLPSKSVDWTHFGGSPPSDEIRTLRDQLL 696
+D + + +E + + + A+A S+ L + L ++ T D++ D
Sbjct: 1381 DDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLD--- 1437
Query: 697 LLHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQK 756
H + + +++Q K I A EE + A + + +EK+ + ++
Sbjct: 1438 --HQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRA---EAEAREKETKALSLARAL 1492
Query: 757 EQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKK 816
E+A + +E+ + +L + + L +++ EL+ + E+R +L++
Sbjct: 1493 EEAL--EAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEE 1550
Query: 817 ANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNE----LYLEQLQNKHSD 872
+++ TE KL ++Q R L E NE L ++Q++ ++
Sbjct: 1551 LEDELQATE------DAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAE 1604
Query: 873 TTKEVEM--MKAAYRKELE--------------KNRSHVLQQTQRLDTSQKRI-LELESH 915
E + + A +K++E K R V++Q ++L K ELE
Sbjct: 1605 LEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEA 1664
Query: 916 LAKKDHLLLEQK------KYLEDVKLQARGQLQAAE--SRYEAQKRITQVFEL------- 960
A +D + + K K LE LQ + +L ++E R+ Q+R E+
Sbjct: 1665 RASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGK 1724
Query: 961 -EILDLYGRLEKDGLLKKLEEEKAEAAEAAEERLDCCND 998
+LD RLE + +LEEE E + ++ ND
Sbjct: 1725 SALLDEKRRLE--ARIAQLEEE----LEEEQSNMELLND 1757
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 61.6 bits (148), Expect = 4e-09
Identities = 73/347 (21%), Positives = 152/347 (43%), Gaps = 24/347 (6%)
Query: 683 PPSDEIRTLRDQL-LLLHNQLLYERFKRQQHALRN----RRLLRKVIKAAALEEHNAAMK 737
P S +R LR L + NQ+L + +++ LR K + +E+ ++
Sbjct: 484 PASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLE 543
Query: 738 DQLKLQEKD-IQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQEL 796
+ + +E + ++ KV K + R +++ +R+ + K+ +++ +EE Q ++
Sbjct: 544 NLRRKEEAEQLRRQKVEEDKRR-RLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQK 602
Query: 797 QTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLG 856
++++ E R+ +KA K ++K+ E+ ++Q E R +
Sbjct: 603 FAQIDEKTEKAKEERLAEEKAKKKAA---------AKKMEEVEARRKQEEEARRLRWLQQ 653
Query: 857 EVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHL 916
E E ++L K + +E + KAA K L + R ++ +R + ++ E
Sbjct: 654 EEEERRHQELLQKKKEEEQE-RLRKAAEAKRLAEQREQERREQERREQERREQERREQER 712
Query: 917 AKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGL-- 974
+++ L EQ++ E +LQA +LQ E QK + + E+ + + E+ L
Sbjct: 713 REQERQLAEQERRREQERLQAERELQEREKALRLQK---EQLQRELEEKKKKEEQQRLAE 769
Query: 975 --LKKLEEEKAEAAEAAEERLDCCNDGCSDSMVGHNEEASGHNGETK 1019
L++ +E+KA+ A A + L+ D S + + GH K
Sbjct: 770 RQLQEEQEKKAKEAAGASKALNVTVDVQSPACTSYQMTPQGHRAPPK 816
>gi|46593000 GRIP1 associated protein 1 isoform 2 [Homo sapiens]
Length = 625
Score = 61.2 bits (147), Expect = 5e-09
Identities = 88/390 (22%), Positives = 163/390 (41%), Gaps = 49/390 (12%)
Query: 620 VIRKTEELLKKAKGNTEEDGVPSTSPMEVLDRLIQQGADAHSKELNKLPLPSKSVDWTHF 679
V+ E+L+ + EED S + + + + + KE K S+
Sbjct: 70 VLLSENEMLQAKLHSQEEDFRLQNSTL-----MAEFSKERYGKEAGKFSAVSEGQ----- 119
Query: 680 GGSPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQ 739
G PP T+ + L +L +E K ++ L + + ++++ E + ++
Sbjct: 120 -GDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQL---QGLESSKQAETSRLQEEL 175
Query: 740 LKLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYN----QSQE 795
KL EK L+K+Q + +LQ +++T+ ++I +LQ +E + ++Q+
Sbjct: 176 AKLSEK--------LKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQK 227
Query: 796 LQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQME-------FL 848
LQ +LE +AELR + + ++ H L + Q S Q+Q+E L
Sbjct: 228 LQQELEAANQSLAELRDQ--RQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNAL 285
Query: 849 NRQLLVLGEVNELYLEQLQNKHSDTT---KEVEMMKAAYRKELEKNRSHVLQQTQRLDTS 905
L L ++ ++L TT E++ +A Y ++L + + Q Q +
Sbjct: 286 RTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEY-EDLMGQKDDLNSQLQESLRA 344
Query: 906 QKRILE-LESHLAKKDHL---LLEQKKYLEDVKLQ----ARGQLQAAESRYEAQKRITQV 957
R+LE L+ +K+ L L E +K E K A LQ E +
Sbjct: 345 NSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLR 404
Query: 958 FELEILDLYGRLEKDGLLKKLEEEKAEAAE 987
E E+L + R E++ L++L E+K E
Sbjct: 405 HEKEVLGVRARYERE--LRELHEDKKRQEE 432
Score = 61.2 bits (147), Expect = 5e-09
Identities = 76/322 (23%), Positives = 134/322 (41%), Gaps = 41/322 (12%)
Query: 688 IRTLRDQLLL--LHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEK 745
+R L+DQ+ + Q E + +ALR AALE+ A +L + +
Sbjct: 257 LRALQDQVSIQSADAQEQVEGLLAENNALRT--------SLAALEQIQTAKTQELNMLRE 308
Query: 746 DIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRN 805
LQ++QA Y L Q+D L+SQ+++ Q QE+ + E
Sbjct: 309 QTTGLAAELQQQQAEYEDLMGQKD----DLNSQLQESLRANSRLLEQLQEIGQEKEQLTQ 364
Query: 806 MIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQ 865
+ E R +K K EL + + +K + E + L + VLG V Y +
Sbjct: 365 ELQEARKSAEK--RKAMLDELAMETLQEKSQHKEELGAVR--LRHEKEVLG-VRARYERE 419
Query: 866 LQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKD----- 920
L+ H D ++ E ++ R+E + T+ L+T Q+ + EL++ + D
Sbjct: 420 LRELHEDKKRQEEELRGQIREEKAR--------TRELETLQQTVEELQAQVHSMDGAKGW 471
Query: 921 -HLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGR---LEKDG--L 974
L++ + E+ R QL+ A+ + + + E+ D LEK G
Sbjct: 472 FERRLKEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAA 531
Query: 975 LKKLEEE---KAEAAEAAEERL 993
LK L+ + + + A+ +ERL
Sbjct: 532 LKDLKRQLHLERKRADKLQERL 553
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 60.5 bits (145), Expect = 9e-09
Identities = 70/343 (20%), Positives = 149/343 (43%), Gaps = 20/343 (5%)
Query: 683 PPSDEIRTLRDQL-LLLHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLK 741
P S +R LR L + NQ+L + +++ ++ E+ +++ +
Sbjct: 484 PASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRR 543
Query: 742 LQEKD-IQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKL 800
+E + ++ KV K + R +++ +R+ + K+ +++ +EE Q ++ ++
Sbjct: 544 KEEAEQLRRQKVEEDKRR-RLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQI 602
Query: 801 EDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNE 860
++ E R+ +KA K ++K+ E+ ++Q E R + E E
Sbjct: 603 DEKTEKAKEERLAEEKAKKKAA---------AKKMEEVEARRKQEEEARRLRWLQQEEEE 653
Query: 861 LYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKD 920
++L K + +E + KAA K L + R ++ +R + ++ E +++
Sbjct: 654 RRHQELLQKKKEEEQE-RLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQE 712
Query: 921 HLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGL----LK 976
L EQ++ E +LQA +LQ E QK + + E+ + + E+ L L+
Sbjct: 713 RQLAEQERRREQERLQAERELQEREKALRLQK---EQLQRELEEKKKKEEQQRLAERQLQ 769
Query: 977 KLEEEKAEAAEAAEERLDCCNDGCSDSMVGHNEEASGHNGETK 1019
+ +E+KA+ A A + L+ D S + + GH K
Sbjct: 770 EEQEKKAKEAAGASKALNVTVDVQSPACTSYQMTPQGHRAPPK 812
>gi|223634475 golgi autoantigen, golgin subfamily a, 6D [Homo sapiens]
Length = 693
Score = 60.1 bits (144), Expect = 1e-08
Identities = 73/345 (21%), Positives = 155/345 (44%), Gaps = 38/345 (11%)
Query: 705 ERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQL 764
+R + A+ RRL + + + A L H + + LK + + + ++ E+AR+ +
Sbjct: 187 DRSSSCREAVLQRRLQQTIKERALLNAHVTQVTESLKQVQLERDEYAKHIKGERARWQE- 245
Query: 765 QEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAE--------LRIELKK 816
+ K+ + R L+ +++ ++ QEL+ L + +N +AE + +++
Sbjct: 246 ------RMWKMSVEARTLKEEKKRDIHRIQELERSLSELKNQMAEPPSLAPPAVTSVVEQ 299
Query: 817 ANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNR-QLLVLGEVNELYLEQLQNKHSDTTK 875
++ H + + KL + Q + L++ Q L E E+ EQ + + +
Sbjct: 300 LQDEAKHLRQEVEGLEGKLQSQVENNQALSLLSKEQKQRLQEQEEMLREQEAQRVREQER 359
Query: 876 EVEMMKAA--YRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYL--E 931
E + +K L++ + +Q QRL ++R+ + E L K++ L +Q++ L +
Sbjct: 360 LCEQNERLREQQKTLQEQGERLRKQEQRLRKQEERLRKEEERLQKQEKRLWDQEERLWKK 419
Query: 932 DVKLQARGQLQAAESRYEAQKRITQVFELEILDLYG------RLEKD--GLLKKLEEEKA 983
+ +LQ + + A ++ K++ + + DL +LE+ L +KL+EE
Sbjct: 420 EERLQKQEERLALSQNHKLDKQLAEP-QCSFEDLNNEKKSALQLEQQVKELQEKLDEEHL 478
Query: 984 EAAEAAEERLDCCNDGCSDSMVGHNEEASG----HNGETKTPRPS 1024
EAA ++L+ S+V E G + E + PRP+
Sbjct: 479 EAASQRNQQLE-----TQLSLVALPGEGDGGQHLDSEEEEAPRPT 518
Score = 36.6 bits (83), Expect = 0.14
Identities = 56/262 (21%), Positives = 105/262 (40%), Gaps = 33/262 (12%)
Query: 731 EHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFY 790
E+N A+ K Q++ +Q + L++++A+ + QE+ +L Q + LQ E
Sbjct: 323 ENNQALSLLSKEQKQRLQEQEEMLREQEAQRVREQERLCEQNERLREQQKTLQEQGERLR 382
Query: 791 NQSQELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNR 850
Q Q L+ + E L+K ++ E L ++L E Q+ E
Sbjct: 383 KQEQRLRKQEE-----------RLRKEEERLQKQEKRLWDQEERLWKKEERLQKQE---- 427
Query: 851 QLLVLGEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRIL 910
+ L L + ++L K++ + ++ ++L + LQ Q++ Q+++
Sbjct: 428 ERLALSQNHKL------------DKQLAEPQCSF-EDLNNEKKSALQLEQQVKELQEKLD 474
Query: 911 ELESHLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRLE 970
E A + + LE + L + + G EA + + E DL R E
Sbjct: 475 EEHLEAASQRNQQLETQLSLVALPGEGDGGQHLDSEEEEAPRPTPNIPE----DLESR-E 529
Query: 971 KDGLLKKLEEEKAEAAEAAEER 992
L +EKA+ E E R
Sbjct: 530 ATSSFMDLPKEKADGTEQVERR 551
Score = 35.4 bits (80), Expect = 0.32
Identities = 62/309 (20%), Positives = 132/309 (42%), Gaps = 42/309 (13%)
Query: 686 DEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQ---LKL 742
++ + L++Q +L Q +R + Q+ LR+ K L+E ++ Q L+
Sbjct: 334 EQKQRLQEQEEMLREQEA-QRVREQERLCEQNERLREQQKT--LQEQGERLRKQEQRLRK 390
Query: 743 QEKDIQMWKVSLQKEQARY-----------NQLQEQRDTMVT----KLHSQIRQLQHDRE 787
QE+ ++ + LQK++ R +LQ+Q + + KL Q+ + Q E
Sbjct: 391 QEERLRKEEERLQKQEKRLWDQEERLWKKEERLQKQEERLALSQNHKLDKQLAEPQCSFE 450
Query: 788 EFYNQSQ---ELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQ 844
+ N+ + +L+ ++++ + + E +E N+ T+L L + + + + +
Sbjct: 451 DLNNEKKSALQLEQQVKELQEKLDEEHLEAASQRNQQLETQLSLVALPGEGDGGQHLDSE 510
Query: 845 MEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDT 904
E R + E +L + + D KE KA +++E+ +Q + D
Sbjct: 511 EEEAPRPTPNIPE--DLESREATSSFMDLPKE----KADGTEQVERRELGFVQPSGVTDG 564
Query: 905 SQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILD 964
++ ES A + + + +EDV ++ A+ E + ++ ++ EL +L
Sbjct: 565 MRESFTVYESQGAVPN----TRHQEMEDV-------IRLAQKEEEMKVKLLELQEL-VLP 612
Query: 965 LYGRLEKDG 973
L G E G
Sbjct: 613 LVGNHEGHG 621
>gi|51472437 PREDICTED: golgi autoantigen, golgin subfamily a, 6C
isoform 1 [Homo sapiens]
Length = 693
Score = 60.1 bits (144), Expect = 1e-08
Identities = 73/345 (21%), Positives = 155/345 (44%), Gaps = 38/345 (11%)
Query: 705 ERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQL 764
+R + A+ RRL + + + A L H + + LK + + + ++ E+AR+ +
Sbjct: 187 DRSSSCREAVLQRRLQQTIKERALLNAHVTQVTESLKQVQLERDEYAKHIKGERARWQE- 245
Query: 765 QEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAE--------LRIELKK 816
+ K+ + R L+ +++ ++ QEL+ L + +N +AE + +++
Sbjct: 246 ------RMWKMSVEARTLKEEKKRDIHRIQELERSLSELKNQMAEPPSLAPPAVTSVVEQ 299
Query: 817 ANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNR-QLLVLGEVNELYLEQLQNKHSDTTK 875
++ H + + KL + Q + L++ Q L E E+ EQ + + +
Sbjct: 300 LQDEAKHLRQEVEGLEGKLQSQVENNQALSLLSKEQKQRLQEQEEMLREQEAQRVREQER 359
Query: 876 EVEMMKAA--YRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYL--E 931
E + +K L++ + +Q QRL ++R+ + E L K++ L +Q++ L +
Sbjct: 360 LCEQNERLREQQKTLQEQGERLRKQEQRLRKQEERLRKEEERLQKQEKRLWDQEERLWKK 419
Query: 932 DVKLQARGQLQAAESRYEAQKRITQVFELEILDLYG------RLEKD--GLLKKLEEEKA 983
+ +LQ + + A ++ K++ + + DL +LE+ L +KL+EE
Sbjct: 420 EERLQKQEERLALSQNHKLDKQLAEP-QCSFEDLNNEKKSALQLEQQVKELQEKLDEEHL 478
Query: 984 EAAEAAEERLDCCNDGCSDSMVGHNEEASG----HNGETKTPRPS 1024
EAA ++L+ S+V E G + E + PRP+
Sbjct: 479 EAASQRNQQLE-----TQLSLVALPGEGDGGQHLDSEEEEAPRPT 518
Score = 36.6 bits (83), Expect = 0.14
Identities = 56/262 (21%), Positives = 105/262 (40%), Gaps = 33/262 (12%)
Query: 731 EHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFY 790
E+N A+ K Q++ +Q + L++++A+ + QE+ +L Q + LQ E
Sbjct: 323 ENNQALSLLSKEQKQRLQEQEEMLREQEAQRVREQERLCEQNERLREQQKTLQEQGERLR 382
Query: 791 NQSQELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNR 850
Q Q L+ + E L+K ++ E L ++L E Q+ E
Sbjct: 383 KQEQRLRKQEE-----------RLRKEEERLQKQEKRLWDQEERLWKKEERLQKQE---- 427
Query: 851 QLLVLGEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRIL 910
+ L L + ++L K++ + ++ ++L + LQ Q++ Q+++
Sbjct: 428 ERLALSQNHKL------------DKQLAEPQCSF-EDLNNEKKSALQLEQQVKELQEKLD 474
Query: 911 ELESHLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRLE 970
E A + + LE + L + + G EA + + E DL R E
Sbjct: 475 EEHLEAASQRNQQLETQLSLVALPGEGDGGQHLDSEEEEAPRPTPNIPE----DLESR-E 529
Query: 971 KDGLLKKLEEEKAEAAEAAEER 992
L +EKA+ E E R
Sbjct: 530 ATSSFMDLPKEKADGTEQVERR 551
Score = 35.4 bits (80), Expect = 0.32
Identities = 62/309 (20%), Positives = 132/309 (42%), Gaps = 42/309 (13%)
Query: 686 DEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQ---LKL 742
++ + L++Q +L Q +R + Q+ LR+ K L+E ++ Q L+
Sbjct: 334 EQKQRLQEQEEMLREQEA-QRVREQERLCEQNERLREQQKT--LQEQGERLRKQEQRLRK 390
Query: 743 QEKDIQMWKVSLQKEQARY-----------NQLQEQRDTMVT----KLHSQIRQLQHDRE 787
QE+ ++ + LQK++ R +LQ+Q + + KL Q+ + Q E
Sbjct: 391 QEERLRKEEERLQKQEKRLWDQEERLWKKEERLQKQEERLALSQNHKLDKQLAEPQCSFE 450
Query: 788 EFYNQSQ---ELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQ 844
+ N+ + +L+ ++++ + + E +E N+ T+L L + + + + +
Sbjct: 451 DLNNEKKSALQLEQQVKELQEKLDEEHLEAASQRNQQLETQLSLVALPGEGDGGQHLDSE 510
Query: 845 MEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDT 904
E R + E +L + + D KE KA +++E+ +Q + D
Sbjct: 511 EEEAPRPTPNIPE--DLESREATSSFMDLPKE----KADGTEQVERRELGFVQPSGVTDG 564
Query: 905 SQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILD 964
++ ES A + + + +EDV ++ A+ E + ++ ++ EL +L
Sbjct: 565 MRESFTVYESQGAVPN----TRHQEMEDV-------IRLAQKEEEMKVKLLELQEL-VLP 612
Query: 965 LYGRLEKDG 973
L G E G
Sbjct: 613 LVGNHEGHG 621
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sapiens]
Length = 570
Score = 59.7 bits (143), Expect = 2e-08
Identities = 84/428 (19%), Positives = 185/428 (43%), Gaps = 50/428 (11%)
Query: 602 PPYDHLFEVALPKTAHHFVIRKTEELLKKAKGNTE-EDGVPSTSPMEVLDRLIQQGADAH 660
P + HL P H ++ K K A+ + D P T+P + +D
Sbjct: 22 PTHPHL--PTHPHLPTHPMMSKETRQSKLAEAKEQLTDHHPQTNPS-----VGTAASDTK 74
Query: 661 SKELNKLPLPSKSVDWTHFGGSPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLL 720
K++N P + T G P DE + H + L + Q +R
Sbjct: 75 KKKINNGTNPETT---TSGGCHSPEDEQKASHQ-----HQEALRRELEAQVQTIRILTCQ 126
Query: 721 RKVIKAAALEEHNAAMKDQLKLQEKDI-----QMWKVSLQKEQA------------RY-N 762
+ ++ A +A QL+ + +D+ WK + + EQA RY
Sbjct: 127 KTELQMALYYSQHAVK--QLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIE 184
Query: 763 QLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVC 822
+L ++RD + +L+ R D EE ++ +LQ KL+ + +E+++ +K+ K+
Sbjct: 185 ELTKERDALSLELY---RNTITD-EELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLE 240
Query: 823 HTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVEMMKA 882
+LLL Q Q + ++ + ++++ ++ +L E NEL+ Q + ++ E ++
Sbjct: 241 RAKLLLPQ-QQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQE 299
Query: 883 AYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQLQ 942
K +++ + +Q +++ ++ + E E + +++ ++ E+++ + +++ + Q +
Sbjct: 300 REEK-IQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEK 358
Query: 943 AAESRYEAQKRITQVFELEILDLYGRLEKDGLLKKLEEEKAEAAEAAEERLDCCNDGCSD 1002
E + Q+ E +I + R E++ + + EE+ E E E+ + + +
Sbjct: 359 IREQEEKRQE------EEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQE--QE 410
Query: 1003 SMVGHNEE 1010
+G EE
Sbjct: 411 EKMGEQEE 418
Score = 52.8 bits (125), Expect = 2e-06
Identities = 49/256 (19%), Positives = 121/256 (47%), Gaps = 20/256 (7%)
Query: 743 QEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLED 802
Q+++ +MW+ +K Q R ++QEQ + K+ Q +++ E + + ++++ + E
Sbjct: 284 QQQEEKMWRQE-EKIQEREEKIQEQEE----KIREQEEKMRRQEEMMWEKEEKMRRQEE- 337
Query: 803 CRNMIAELRIELKKANNKVCHTELLLSQVS-----QKLSNSESVQQQMEFLNRQLLVLGE 857
M+ E ++++ K+ E + Q +K+ E Q+Q + RQ + E
Sbjct: 338 ---MMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIRE 394
Query: 858 VNELYLEQ--LQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESH 915
E EQ + + + E E +E+++ + +Q +++ +K+I E E
Sbjct: 395 QEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEK 454
Query: 916 LAKKDHLLLEQKKYL---EDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRL-EK 971
+ +++ ++ EQ++ + E + ++Q E + Q+ + E +I + ++ E+
Sbjct: 455 IREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQ 514
Query: 972 DGLLKKLEEEKAEAAE 987
+ ++++ EE+ E E
Sbjct: 515 EEMMQEQEEKMWEQEE 530
Score = 52.4 bits (124), Expect = 3e-06
Identities = 40/242 (16%), Positives = 113/242 (46%), Gaps = 7/242 (2%)
Query: 705 ERFKRQQHAL--RNRRLLRKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYN 762
E+ +RQ+ + + ++ R+ EE +++++ QEK + + ++E+ R
Sbjct: 316 EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQ 375
Query: 763 QLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVC 822
+ +++++ + + +IR+ + E QE + K+ + + E E+++ K+
Sbjct: 376 EKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMR 435
Query: 823 HTELLLSQVSQKL-SNSESVQQQMEFLNRQLLVLGEVNELYLEQ---LQNKHSDTTKEVE 878
E + + +K+ E +++Q E + Q +GE EQ +Q + ++ E
Sbjct: 436 RQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEE 495
Query: 879 MMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQAR 938
++ K++ + + +Q + + ++++ E E + +++ + EQ++ + + + R
Sbjct: 496 KIR-EQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMR 554
Query: 939 GQ 940
Q
Sbjct: 555 EQ 556
Score = 46.6 bits (109), Expect = 1e-04
Identities = 48/273 (17%), Positives = 119/273 (43%), Gaps = 25/273 (9%)
Query: 700 NQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQA 759
NQ E+ RQ+ ++ R K EE +++++ QE+ + + +++++
Sbjct: 283 NQQQEEKMWRQEEKIQEREE-----KIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEE 337
Query: 760 RYNQLQEQRDTMVTKLHSQ--IRQLQHDREE-----FYNQSQELQTKLEDCRNMIAELRI 812
+ +E+ + K+H Q IR+ + R+E + QE + K+ I E
Sbjct: 338 MMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEE 397
Query: 813 ELKKANNKVCHTELLLSQVSQKL-SNSESVQQQMEFLNRQLLVLGEVNELYLEQ------ 865
++++ + E + + +K+ E +Q+Q E + RQ + E + EQ
Sbjct: 398 KIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIRE 457
Query: 866 ---LQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHL 922
+ + + E E ++++ + +Q +++ +K+I E E + +++ +
Sbjct: 458 QEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEM 517
Query: 923 LLEQKKYL---EDVKLQARGQLQAAESRYEAQK 952
+ EQ++ + E+ + ++Q E + Q+
Sbjct: 518 MQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQE 550
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 59.3 bits (142), Expect = 2e-08
Identities = 86/424 (20%), Positives = 184/424 (43%), Gaps = 55/424 (12%)
Query: 602 PPYDHLFEVALPKTAHHFVIRKTEELLKKAKGNTE-EDGVPSTSPMEVLDRLIQQGADAH 660
P + HL P H ++ K K A+ + D P T+P + +D
Sbjct: 34 PTHPHL--PTHPHLPTHPMMSKETRQSKLAEAKEQLTDHHPQTNPS-----VGTAASDTK 86
Query: 661 SKELNKLPLPSKSVDWTHFGGSPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLL 720
K++N P + T G P DE + H + L + Q H +R
Sbjct: 87 KKKINNGTNPETT---TSGGCHSPEDEQKASHQ-----HQEALRRELEAQVHTIRILTCQ 138
Query: 721 RKVIKAAALEEHNAAMKDQLKLQEKDI-----QMWKVSLQKEQA------------RY-N 762
+ ++ A +A QL+ + +D+ WK + + EQA RY
Sbjct: 139 KTELQMALYYSQHAVK--QLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIE 196
Query: 763 QLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVC 822
+L ++RD + +L+ R D EE ++ +LQ KL+ + +E+++ +K+ K+
Sbjct: 197 ELTKERDALSLELY---RNTITD-EELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLE 252
Query: 823 HTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELY--LEQLQN----KHSDTTKE 876
+LLL Q Q + ++ + ++++ ++ +L E NEL+ L Q Q + + +E
Sbjct: 253 RAKLLLPQ-QQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQE 311
Query: 877 VEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQK---KYLEDV 933
E +++ + + +Q +++ ++ + E E + +++ ++ E++ + LE++
Sbjct: 312 WEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEM 371
Query: 934 KLQARGQLQAAESRYEAQKRITQVFEL-----EILDLYGRLEKDGLLKKLEEEKAEAAEA 988
+ +++ E + Q++I + E +I + R E++ + + EE+ E E
Sbjct: 372 MWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEK 431
Query: 989 AEER 992
E+
Sbjct: 432 IREQ 435
Score = 48.1 bits (113), Expect = 5e-05
Identities = 35/222 (15%), Positives = 99/222 (44%), Gaps = 39/222 (17%)
Query: 733 NAAMKDQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQ 792
N ++++ QE+ IQ W+ +Q+++ + + +E K+ Q +++ E + +
Sbjct: 295 NQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEE-------KIREQEEKMRRQEEMMWEK 347
Query: 793 SQELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQL 852
++++ + E M+ E ++++ + E + ++ +K+ E +++Q E
Sbjct: 348 EEKMRRQEE----MMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEE------ 397
Query: 853 LVLGEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILEL 912
K E K +++ ++ + + +Q +++ +++I E
Sbjct: 398 ----------------------KRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQ 435
Query: 913 ESHLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRI 954
E + +++ + EQ+K E+ K Q + ++ E + Q+ I
Sbjct: 436 EKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEI 477
Score = 48.1 bits (113), Expect = 5e-05
Identities = 42/233 (18%), Positives = 108/233 (46%), Gaps = 18/233 (7%)
Query: 709 RQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQK-EQARYNQLQEQ 767
RQ+ + + +R+ K EE + + K++E++ ++W+ + EQ + + +E+
Sbjct: 441 RQEEKIHEQEKIREEEKRQEQEE---MWRQEEKIREQE-EIWRQKEKMHEQEKIRKQEEK 496
Query: 768 RDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHTELL 827
K+H Q +++ E+ + Q ++++ + E R E ++++ + E
Sbjct: 497 VWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIR----EQEEKIREQEEMMQEQEEK 552
Query: 828 LSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQ---LQNKHSDTTKEVEMMKAAY 884
+ + +K+ E +++Q E + Q + E E EQ + + ++ EMM+
Sbjct: 553 MGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQE 612
Query: 885 RKELE------KNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLE 931
K E + + +Q +++ ++++ E E L +++ + E +++LE
Sbjct: 613 EKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLE 665
Score = 43.5 bits (101), Expect = 0.001
Identities = 38/296 (12%), Positives = 132/296 (44%), Gaps = 25/296 (8%)
Query: 705 ERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQL 764
E+ + Q+ +R + + + + + + K++ ++ MW+ +++ R ++
Sbjct: 314 EKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEK--EEKMRRLEEM 371
Query: 765 QEQRDTMVTKLHSQIRQLQHDREEFYNQSQEL----QTKLEDCRNMIAELRIELKKANNK 820
+++ + +L ++ + + RE+ + +E Q K ++ + ++++ K
Sbjct: 372 MWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEK 431
Query: 821 VCHTELLLSQVSQKLSNSESV-----QQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTK 875
+ E + + +K+ E + +Q+ E + RQ + E E++ ++ + + +
Sbjct: 432 IREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIR 491
Query: 876 EVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKL 935
+ E +++ + +Q +++ +++I E E + +++ + EQ++ +++ +
Sbjct: 492 KQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEE 551
Query: 936 QARGQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLLKKLEEEKAEAAEAAEE 991
+ Q + + + + +++ ++ E E +K+ E+K + E E+
Sbjct: 552 KMGEQEEKMQEQEKMRRQEEKIREQE--------------EKIREQKEKIREQEEK 593
Score = 38.5 bits (88), Expect = 0.038
Identities = 27/152 (17%), Positives = 71/152 (46%), Gaps = 6/152 (3%)
Query: 705 ERFKRQQHALRNR--RLLRKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYN 762
E+ Q+ +R + ++ R+ K EE +++++ QE+ +Q + + +++ +
Sbjct: 502 EKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQ 561
Query: 763 QLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQEL---QTKLEDCRNMIAELRIELKKANN 819
+ QE+ K+ Q +++ +E+ Q +++ + K+ + M+ E ++ +
Sbjct: 562 E-QEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEE 620
Query: 820 KVCHTELLLSQVSQKLSNSESVQQQMEFLNRQ 851
K+C E + + +K+ E + E RQ
Sbjct: 621 KMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQ 652
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 59.3 bits (142), Expect = 2e-08
Identities = 57/316 (18%), Positives = 147/316 (46%), Gaps = 23/316 (7%)
Query: 686 DEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEK 745
+E+ +++ + ++++E+ ++ + K+ + + +++Q K QE+
Sbjct: 416 EEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQ 475
Query: 746 DIQMWKVSLQKEQARYNQLQEQRDTM---VTKLHSQIR----QLQHDREEFYNQSQELQT 798
+ +MW+ +K + + +++EQ + M K+H Q + + + ++EE + Q ++++
Sbjct: 476 EAKMWRQE-EKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIRE 534
Query: 799 KLEDCRNM--IAELRIELKKANNKVCHTELLLSQVSQKL-SNSESVQQQMEFLNRQLLVL 855
+ E R I E +++K K+ E + +K+ E V +Q E + Q +
Sbjct: 535 QEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKI 594
Query: 856 GEVNELYLEQ--LQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELE 913
E E EQ + + + E E +++++ + +Q +++ +K+I E E
Sbjct: 595 REQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQE 654
Query: 914 SHLAKKDHLLLEQKKYL---EDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRLE 970
+ +++ ++ EQ++ + E+ + ++Q E + Q+ +++E E+ RL
Sbjct: 655 EKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEE--KMWEQEV-----RLR 707
Query: 971 KDGLLKKLEEEKAEAA 986
+ + +E EAA
Sbjct: 708 QQEEKMQEHQEHLEAA 723
Score = 58.5 bits (140), Expect = 4e-08
Identities = 83/410 (20%), Positives = 181/410 (44%), Gaps = 48/410 (11%)
Query: 602 PPYDHLFEVALPKTAHHFVIRKTEELLKKAKGNTE-EDGVPSTSPMEVLDRLIQQGADAH 660
P + HL P H ++ K K A+ + D P T+P + +D
Sbjct: 95 PTHPHL--PTHPHLPTHPMMSKETRQSKLAEAKEQLTDHHPQTNPS-----VGTAASDTK 147
Query: 661 SKELNKLPLPSKSVDWTHFGGSPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLL 720
K++N P + T G P DE + H + L + Q H +R
Sbjct: 148 KKKINNGTNPETT---TSGGCHSPEDEQKASHQ-----HQEALRRELEAQVHTIRILTCQ 199
Query: 721 RKVIKAAALEEHNAAMKDQLKLQEKDI-----QMWKVSLQKEQA------------RY-N 762
+ ++ A +A QL+ + +D+ WK + + EQA RY
Sbjct: 200 KTELQMALYYSQHAVK--QLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIE 257
Query: 763 QLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVC 822
+L ++RD + +L+ R D EE ++ +LQ KL+ + +E+++ +K+ K+
Sbjct: 258 ELTKERDALSLELY---RNTITD-EELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLE 313
Query: 823 HTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVEMMKA 882
+LLL Q Q + ++ + ++++ ++ +L E NEL+ Q + ++ E ++
Sbjct: 314 RAKLLLPQ-QQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQ- 371
Query: 883 AYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQLQ 942
+ +++++ + +Q +++ ++++ E + +K+ + Q++ + + + + R Q
Sbjct: 372 EWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQ-- 429
Query: 943 AAESRYEAQKRITQVFELEILDLYGRLEKDGLLKKLEEEKAEAAEAAEER 992
E +E +++I ++ E R +++ K+ EEEK E +E+
Sbjct: 430 -EEMMWEKEEKIRELEEKMHEQEKIREQEE---KRQEEEKIREQEKRQEQ 475
Score = 48.1 bits (113), Expect = 5e-05
Identities = 35/222 (15%), Positives = 99/222 (44%), Gaps = 39/222 (17%)
Query: 733 NAAMKDQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQ 792
N ++++ QE+ IQ W+ +Q+++ + + +E K+ Q +++ E + +
Sbjct: 356 NQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEE-------KIREQEEKMRRQEEMMWEK 408
Query: 793 SQELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQL 852
++++ + E M+ E ++++ + E + ++ +K+ E +++Q E
Sbjct: 409 EEKMRRQEE----MMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEE------ 458
Query: 853 LVLGEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILEL 912
K E K +++ ++ + + +Q +++ +++I E
Sbjct: 459 ----------------------KRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQ 496
Query: 913 ESHLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRI 954
E + +++ + EQ+K E+ K Q + ++ E + Q+ I
Sbjct: 497 EEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEI 538
Score = 44.3 bits (103), Expect = 7e-04
Identities = 46/304 (15%), Positives = 137/304 (45%), Gaps = 23/304 (7%)
Query: 705 ERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQL 764
E+ + Q+ +R + + + + + + K++ ++ MW+ +++ R ++
Sbjct: 375 EKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEK--EEKMRRQEEM 432
Query: 765 QEQRDTMVTKLHSQIRQLQHDREEFYNQSQEL----QTKLEDCRNMIAELRIELKKANNK 820
+++ + +L ++ + + RE+ + +E Q K ++ + ++++ K
Sbjct: 433 MWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEK 492
Query: 821 VCHTELLLSQVSQKLSNSESV-----QQQMEFLNRQLLVLGEVNELY--LEQLQNKHSDT 873
+ E + + +K+ E + +Q+ E + RQ + E E++ E++ +
Sbjct: 493 IREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKI 552
Query: 874 TKEVEMMKAAYRK------ELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQK 927
K+ E M K ++ + V +Q +++ +++I E E + +++ + EQ+
Sbjct: 553 RKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQE 612
Query: 928 KYL---EDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRL-EKDGLLKKLEEEKA 983
+ + E+ + ++Q E + Q+ + E +I + ++ E++ ++++ EE+
Sbjct: 613 EKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMW 672
Query: 984 EAAE 987
E E
Sbjct: 673 EQEE 676
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 59.3 bits (142), Expect = 2e-08
Identities = 65/295 (22%), Positives = 134/295 (45%), Gaps = 21/295 (7%)
Query: 711 QHALRNRRLL------RKVIKAAALEEHNAAMKDQLKLQ-EKDIQMWKVSLQKEQARYNQ 763
Q A R R+L ++ + L+E A+++ +L+ E ++ + L +EQAR +
Sbjct: 2288 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR--R 2345
Query: 764 LQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCH 823
LQE ++ M +L + + Q E + E+ + E + +AE+ +A
Sbjct: 2346 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2405
Query: 824 TELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVE-MMKA 882
++ +KL +E Q+ L + L + + ++ E+L+ ++ +E E + +
Sbjct: 2406 FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE 2465
Query: 883 AYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQA----R 938
A +L+ +QQ Q L +Q +S L++KD LL++++++E K + +
Sbjct: 2466 AKLLQLKSEEMQTVQQEQLLQETQAL---QQSFLSEKDS-LLQRERFIEQEKAKLEQLFQ 2521
Query: 939 GQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLLKKLEEEKAEAAEAAEERL 993
++ A+ E Q+R Q E E L +E+ ++ + E E +E L
Sbjct: 2522 DEVAKAQQLREEQQRQQQQMEQERQRLVASMEE---ARRRQHEAEEGVRRKQEEL 2573
Score = 47.8 bits (112), Expect = 6e-05
Identities = 62/307 (20%), Positives = 131/307 (42%), Gaps = 30/307 (9%)
Query: 705 ERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLK----LQEKDIQMWKVSLQKEQAR 760
ER +RQ R+ +V A+ ++ A +++ + L+E +Q + + QA
Sbjct: 1497 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1556
Query: 761 YNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNK 820
+ ++ + + T S +LQ R F ++ +L+ L++ +A+LR E ++ +
Sbjct: 1557 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1616
Query: 821 VCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVE-- 878
E + ++L + + L Q + + L + + + + +E
Sbjct: 1617 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1676
Query: 879 --------MMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYL 930
+ +ELEK R Q+ +++ ++ L + + + +Q++ L
Sbjct: 1677 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE----QQRQLL 1732
Query: 931 EDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLL---KKLEEEKAEAAE 987
E+ AR Q +AA + QKR Q E E+ + R E + LL + EEE +E
Sbjct: 1733 EEE--LARLQREAAAA---TQKR--QELEAELAKV--RAEMEVLLASKARAEEESRSTSE 1783
Query: 988 AAEERLD 994
+++RL+
Sbjct: 1784 KSKQRLE 1790
Score = 46.2 bits (108), Expect = 2e-04
Identities = 72/315 (22%), Positives = 131/315 (41%), Gaps = 38/315 (12%)
Query: 711 QHALRNRRLLRKVIKAA-ALEEHNAAMKDQLKLQ-------EKDIQMWKVSLQKEQARYN 762
+ LR RR + + I A A E AA K +L+L+ +D K + E AR
Sbjct: 1914 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1973
Query: 763 QLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVC 822
QL + + + ++++ EE Q + ++E + + E R ++A +
Sbjct: 1974 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2033
Query: 823 HTELLLSQVSQKLSNSE------SVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTK- 875
L + +QK +E +VQQ+ + L + L + + L+QL+ + +
Sbjct: 2034 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL----QQEQSVLDQLRGEAEAARRA 2089
Query: 876 --EVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDV 933
E E + +E ++R V ++ +RL S + + + L ++ +
Sbjct: 2090 AEEAEEARVQAEREAAQSRRQV-EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2148
Query: 934 KLQARG----QLQAAESRYEAQKRITQV-------FELEILDLYGRLEKDGLLKKLEEE- 981
+ QA Q QAA++ E K+ + E E+ L +LE+ K L +E
Sbjct: 2149 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2208
Query: 982 ----KAEAAEAAEER 992
KAEA EAA +R
Sbjct: 2209 LQRLKAEATEAARQR 2223
Score = 45.4 bits (106), Expect = 3e-04
Identities = 40/159 (25%), Positives = 75/159 (47%), Gaps = 18/159 (11%)
Query: 685 SDEIRTLRDQLLLLHNQLLYERFKRQQHAL--RNRRLLRKVIKAAALEEHNAAMKDQLKL 742
S+E++T++ + LL Q L + F ++ +L R R + ++ K L + A QL+
Sbjct: 2473 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLR- 2531
Query: 743 QEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLED 802
+++Q + Q++++R +V + + R+ QH+ EE + QE +LE
Sbjct: 2532 ------------EEQQRQQQQMEQERQRLVASME-EARRRQHEAEEGVRRKQEELQQLEQ 2578
Query: 803 CRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESV 841
R EL E + + +LL Q L++SE V
Sbjct: 2579 QRRQQEELLAEENQRLRE--QLQLLEEQHRAALAHSEEV 2615
Score = 37.7 bits (86), Expect = 0.064
Identities = 63/292 (21%), Positives = 119/292 (40%), Gaps = 38/292 (13%)
Query: 706 RFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQLQ 765
R ++Q A R R + ++ L+ + A +L+LQ +++ K Q E + +
Sbjct: 1613 RAQQQAEAERAREEAERELERWQLKANEAL---RLRLQAEEVAQQKSLAQAEAEKQKEEA 1669
Query: 766 EQRDTMVTKLHSQ-IRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHT 824
E+ K Q +RQ + +E Q Q +AE + + A +
Sbjct: 1670 EREARRRGKAEEQAVRQRELAEQELEKQRQ------------LAEGTAQQRLAAEQ---- 1713
Query: 825 ELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTK---EVEMMK 881
++ + + +E +QQ + L +L L ++ Q ++ K E+E++
Sbjct: 1714 -----ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1768
Query: 882 AAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQL 941
A+ + E++RS + QRL+ R EL A+ L E K+ + +
Sbjct: 1769 ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ------RQLAEE 1822
Query: 942 QAAESRYEAQKRITQVFELEILDLYGRL--EKDGLLKKLEEEKAEAAEAAEE 991
AA R EA++ + + +L + RL E + LK+ E E AE+
Sbjct: 1823 DAARQRAEAERVLAE--KLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1872
Score = 33.9 bits (76), Expect = 0.93
Identities = 49/269 (18%), Positives = 108/269 (40%), Gaps = 52/269 (19%)
Query: 743 QEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLED 802
++ +++ W+ + + R+ + Q D +L RQL++ RE + L L+D
Sbjct: 1170 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE----SADPLGAWLQD 1225
Query: 803 CRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELY 862
R +++ + L++S++V++Q+ RQ L E E +
Sbjct: 1226 ARRRQEQIQ--------------------AMPLADSQAVREQL----RQEQALLEEIERH 1261
Query: 863 LEQLQ------NKHSDTTKEVEMMKAAYRKELE------------KNRSHVLQQTQRLDT 904
E+++ ++ + K+ E+ Y+ +LE V+Q+ L T
Sbjct: 1262 GEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRT 1321
Query: 905 SQKRILELESH----LAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFEL 960
+ L S +++ + E+++ E + + R +L E+ E Q+++ +
Sbjct: 1322 HYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQ 1381
Query: 961 EILDLYGRLEKDGLLKKLEEEKAEAAEAA 989
E L ++++EE EAA
Sbjct: 1382 --AKAQAEREAKELQQRMQEEVVRREEAA 1408
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 59.3 bits (142), Expect = 2e-08
Identities = 65/295 (22%), Positives = 134/295 (45%), Gaps = 21/295 (7%)
Query: 711 QHALRNRRLL------RKVIKAAALEEHNAAMKDQLKLQ-EKDIQMWKVSLQKEQARYNQ 763
Q A R R+L ++ + L+E A+++ +L+ E ++ + L +EQAR +
Sbjct: 2292 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR--R 2349
Query: 764 LQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCH 823
LQE ++ M +L + + Q E + E+ + E + +AE+ +A
Sbjct: 2350 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2409
Query: 824 TELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVE-MMKA 882
++ +KL +E Q+ L + L + + ++ E+L+ ++ +E E + +
Sbjct: 2410 FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE 2469
Query: 883 AYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQA----R 938
A +L+ +QQ Q L +Q +S L++KD LL++++++E K + +
Sbjct: 2470 AKLLQLKSEEMQTVQQEQLLQETQAL---QQSFLSEKDS-LLQRERFIEQEKAKLEQLFQ 2525
Query: 939 GQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLLKKLEEEKAEAAEAAEERL 993
++ A+ E Q+R Q E E L +E+ ++ + E E +E L
Sbjct: 2526 DEVAKAQQLREEQQRQQQQMEQERQRLVASMEE---ARRRQHEAEEGVRRKQEEL 2577
Score = 47.8 bits (112), Expect = 6e-05
Identities = 62/307 (20%), Positives = 131/307 (42%), Gaps = 30/307 (9%)
Query: 705 ERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLK----LQEKDIQMWKVSLQKEQAR 760
ER +RQ R+ +V A+ ++ A +++ + L+E +Q + + QA
Sbjct: 1501 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1560
Query: 761 YNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNK 820
+ ++ + + T S +LQ R F ++ +L+ L++ +A+LR E ++ +
Sbjct: 1561 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1620
Query: 821 VCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVE-- 878
E + ++L + + L Q + + L + + + + +E
Sbjct: 1621 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1680
Query: 879 --------MMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYL 930
+ +ELEK R Q+ +++ ++ L + + + +Q++ L
Sbjct: 1681 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE----QQRQLL 1736
Query: 931 EDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLL---KKLEEEKAEAAE 987
E+ AR Q +AA + QKR Q E E+ + R E + LL + EEE +E
Sbjct: 1737 EEE--LARLQREAAAA---TQKR--QELEAELAKV--RAEMEVLLASKARAEEESRSTSE 1787
Query: 988 AAEERLD 994
+++RL+
Sbjct: 1788 KSKQRLE 1794
Score = 46.2 bits (108), Expect = 2e-04
Identities = 72/315 (22%), Positives = 131/315 (41%), Gaps = 38/315 (12%)
Query: 711 QHALRNRRLLRKVIKAA-ALEEHNAAMKDQLKLQ-------EKDIQMWKVSLQKEQARYN 762
+ LR RR + + I A A E AA K +L+L+ +D K + E AR
Sbjct: 1918 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1977
Query: 763 QLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVC 822
QL + + + ++++ EE Q + ++E + + E R ++A +
Sbjct: 1978 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2037
Query: 823 HTELLLSQVSQKLSNSE------SVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTK- 875
L + +QK +E +VQQ+ + L + L + + L+QL+ + +
Sbjct: 2038 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL----QQEQSVLDQLRGEAEAARRA 2093
Query: 876 --EVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDV 933
E E + +E ++R V ++ +RL S + + + L ++ +
Sbjct: 2094 AEEAEEARVQAEREAAQSRRQV-EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2152
Query: 934 KLQARG----QLQAAESRYEAQKRITQV-------FELEILDLYGRLEKDGLLKKLEEE- 981
+ QA Q QAA++ E K+ + E E+ L +LE+ K L +E
Sbjct: 2153 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2212
Query: 982 ----KAEAAEAAEER 992
KAEA EAA +R
Sbjct: 2213 LQRLKAEATEAARQR 2227
Score = 45.4 bits (106), Expect = 3e-04
Identities = 40/159 (25%), Positives = 75/159 (47%), Gaps = 18/159 (11%)
Query: 685 SDEIRTLRDQLLLLHNQLLYERFKRQQHAL--RNRRLLRKVIKAAALEEHNAAMKDQLKL 742
S+E++T++ + LL Q L + F ++ +L R R + ++ K L + A QL+
Sbjct: 2477 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLR- 2535
Query: 743 QEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLED 802
+++Q + Q++++R +V + + R+ QH+ EE + QE +LE
Sbjct: 2536 ------------EEQQRQQQQMEQERQRLVASME-EARRRQHEAEEGVRRKQEELQQLEQ 2582
Query: 803 CRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESV 841
R EL E + + +LL Q L++SE V
Sbjct: 2583 QRRQQEELLAEENQRLRE--QLQLLEEQHRAALAHSEEV 2619
Score = 37.7 bits (86), Expect = 0.064
Identities = 63/292 (21%), Positives = 119/292 (40%), Gaps = 38/292 (13%)
Query: 706 RFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQLQ 765
R ++Q A R R + ++ L+ + A +L+LQ +++ K Q E + +
Sbjct: 1617 RAQQQAEAERAREEAERELERWQLKANEAL---RLRLQAEEVAQQKSLAQAEAEKQKEEA 1673
Query: 766 EQRDTMVTKLHSQ-IRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHT 824
E+ K Q +RQ + +E Q Q +AE + + A +
Sbjct: 1674 EREARRRGKAEEQAVRQRELAEQELEKQRQ------------LAEGTAQQRLAAEQ---- 1717
Query: 825 ELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTK---EVEMMK 881
++ + + +E +QQ + L +L L ++ Q ++ K E+E++
Sbjct: 1718 -----ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1772
Query: 882 AAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQL 941
A+ + E++RS + QRL+ R EL A+ L E K+ + +
Sbjct: 1773 ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ------RQLAEE 1826
Query: 942 QAAESRYEAQKRITQVFELEILDLYGRL--EKDGLLKKLEEEKAEAAEAAEE 991
AA R EA++ + + +L + RL E + LK+ E E AE+
Sbjct: 1827 DAARQRAEAERVLAE--KLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1876
Score = 33.9 bits (76), Expect = 0.93
Identities = 49/269 (18%), Positives = 108/269 (40%), Gaps = 52/269 (19%)
Query: 743 QEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLED 802
++ +++ W+ + + R+ + Q D +L RQL++ RE + L L+D
Sbjct: 1174 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE----SADPLGAWLQD 1229
Query: 803 CRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELY 862
R +++ + L++S++V++Q+ RQ L E E +
Sbjct: 1230 ARRRQEQIQ--------------------AMPLADSQAVREQL----RQEQALLEEIERH 1265
Query: 863 LEQLQ------NKHSDTTKEVEMMKAAYRKELE------------KNRSHVLQQTQRLDT 904
E+++ ++ + K+ E+ Y+ +LE V+Q+ L T
Sbjct: 1266 GEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRT 1325
Query: 905 SQKRILELESH----LAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFEL 960
+ L S +++ + E+++ E + + R +L E+ E Q+++ +
Sbjct: 1326 HYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQ 1385
Query: 961 EILDLYGRLEKDGLLKKLEEEKAEAAEAA 989
E L ++++EE EAA
Sbjct: 1386 --AKAQAEREAKELQQRMQEEVVRREEAA 1412
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 59.3 bits (142), Expect = 2e-08
Identities = 65/295 (22%), Positives = 134/295 (45%), Gaps = 21/295 (7%)
Query: 711 QHALRNRRLL------RKVIKAAALEEHNAAMKDQLKLQ-EKDIQMWKVSLQKEQARYNQ 763
Q A R R+L ++ + L+E A+++ +L+ E ++ + L +EQAR +
Sbjct: 2288 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR--R 2345
Query: 764 LQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCH 823
LQE ++ M +L + + Q E + E+ + E + +AE+ +A
Sbjct: 2346 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2405
Query: 824 TELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVE-MMKA 882
++ +KL +E Q+ L + L + + ++ E+L+ ++ +E E + +
Sbjct: 2406 FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE 2465
Query: 883 AYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQA----R 938
A +L+ +QQ Q L +Q +S L++KD LL++++++E K + +
Sbjct: 2466 AKLLQLKSEEMQTVQQEQLLQETQAL---QQSFLSEKDS-LLQRERFIEQEKAKLEQLFQ 2521
Query: 939 GQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLLKKLEEEKAEAAEAAEERL 993
++ A+ E Q+R Q E E L +E+ ++ + E E +E L
Sbjct: 2522 DEVAKAQQLREEQQRQQQQMEQERQRLVASMEE---ARRRQHEAEEGVRRKQEEL 2573
Score = 47.8 bits (112), Expect = 6e-05
Identities = 62/307 (20%), Positives = 131/307 (42%), Gaps = 30/307 (9%)
Query: 705 ERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLK----LQEKDIQMWKVSLQKEQAR 760
ER +RQ R+ +V A+ ++ A +++ + L+E +Q + + QA
Sbjct: 1497 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1556
Query: 761 YNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNK 820
+ ++ + + T S +LQ R F ++ +L+ L++ +A+LR E ++ +
Sbjct: 1557 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1616
Query: 821 VCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVE-- 878
E + ++L + + L Q + + L + + + + +E
Sbjct: 1617 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1676
Query: 879 --------MMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYL 930
+ +ELEK R Q+ +++ ++ L + + + +Q++ L
Sbjct: 1677 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE----QQRQLL 1732
Query: 931 EDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLL---KKLEEEKAEAAE 987
E+ AR Q +AA + QKR Q E E+ + R E + LL + EEE +E
Sbjct: 1733 EEE--LARLQREAAAA---TQKR--QELEAELAKV--RAEMEVLLASKARAEEESRSTSE 1783
Query: 988 AAEERLD 994
+++RL+
Sbjct: 1784 KSKQRLE 1790
Score = 46.2 bits (108), Expect = 2e-04
Identities = 72/315 (22%), Positives = 131/315 (41%), Gaps = 38/315 (12%)
Query: 711 QHALRNRRLLRKVIKAA-ALEEHNAAMKDQLKLQ-------EKDIQMWKVSLQKEQARYN 762
+ LR RR + + I A A E AA K +L+L+ +D K + E AR
Sbjct: 1914 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1973
Query: 763 QLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVC 822
QL + + + ++++ EE Q + ++E + + E R ++A +
Sbjct: 1974 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2033
Query: 823 HTELLLSQVSQKLSNSE------SVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTK- 875
L + +QK +E +VQQ+ + L + L + + L+QL+ + +
Sbjct: 2034 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL----QQEQSVLDQLRGEAEAARRA 2089
Query: 876 --EVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDV 933
E E + +E ++R V ++ +RL S + + + L ++ +
Sbjct: 2090 AEEAEEARVQAEREAAQSRRQV-EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2148
Query: 934 KLQARG----QLQAAESRYEAQKRITQV-------FELEILDLYGRLEKDGLLKKLEEE- 981
+ QA Q QAA++ E K+ + E E+ L +LE+ K L +E
Sbjct: 2149 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2208
Query: 982 ----KAEAAEAAEER 992
KAEA EAA +R
Sbjct: 2209 LQRLKAEATEAARQR 2223
Score = 45.4 bits (106), Expect = 3e-04
Identities = 40/159 (25%), Positives = 75/159 (47%), Gaps = 18/159 (11%)
Query: 685 SDEIRTLRDQLLLLHNQLLYERFKRQQHAL--RNRRLLRKVIKAAALEEHNAAMKDQLKL 742
S+E++T++ + LL Q L + F ++ +L R R + ++ K L + A QL+
Sbjct: 2473 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLR- 2531
Query: 743 QEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLED 802
+++Q + Q++++R +V + + R+ QH+ EE + QE +LE
Sbjct: 2532 ------------EEQQRQQQQMEQERQRLVASME-EARRRQHEAEEGVRRKQEELQQLEQ 2578
Query: 803 CRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESV 841
R EL E + + +LL Q L++SE V
Sbjct: 2579 QRRQQEELLAEENQRLRE--QLQLLEEQHRAALAHSEEV 2615
Score = 37.7 bits (86), Expect = 0.064
Identities = 63/292 (21%), Positives = 119/292 (40%), Gaps = 38/292 (13%)
Query: 706 RFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQLQ 765
R ++Q A R R + ++ L+ + A +L+LQ +++ K Q E + +
Sbjct: 1613 RAQQQAEAERAREEAERELERWQLKANEAL---RLRLQAEEVAQQKSLAQAEAEKQKEEA 1669
Query: 766 EQRDTMVTKLHSQ-IRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHT 824
E+ K Q +RQ + +E Q Q +AE + + A +
Sbjct: 1670 EREARRRGKAEEQAVRQRELAEQELEKQRQ------------LAEGTAQQRLAAEQ---- 1713
Query: 825 ELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTK---EVEMMK 881
++ + + +E +QQ + L +L L ++ Q ++ K E+E++
Sbjct: 1714 -----ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1768
Query: 882 AAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQL 941
A+ + E++RS + QRL+ R EL A+ L E K+ + +
Sbjct: 1769 ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ------RQLAEE 1822
Query: 942 QAAESRYEAQKRITQVFELEILDLYGRL--EKDGLLKKLEEEKAEAAEAAEE 991
AA R EA++ + + +L + RL E + LK+ E E AE+
Sbjct: 1823 DAARQRAEAERVLAE--KLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1872
Score = 33.9 bits (76), Expect = 0.93
Identities = 49/269 (18%), Positives = 108/269 (40%), Gaps = 52/269 (19%)
Query: 743 QEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLED 802
++ +++ W+ + + R+ + Q D +L RQL++ RE + L L+D
Sbjct: 1170 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE----SADPLGAWLQD 1225
Query: 803 CRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELY 862
R +++ + L++S++V++Q+ RQ L E E +
Sbjct: 1226 ARRRQEQIQ--------------------AMPLADSQAVREQL----RQEQALLEEIERH 1261
Query: 863 LEQLQ------NKHSDTTKEVEMMKAAYRKELE------------KNRSHVLQQTQRLDT 904
E+++ ++ + K+ E+ Y+ +LE V+Q+ L T
Sbjct: 1262 GEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRT 1321
Query: 905 SQKRILELESH----LAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFEL 960
+ L S +++ + E+++ E + + R +L E+ E Q+++ +
Sbjct: 1322 HYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQ 1381
Query: 961 EILDLYGRLEKDGLLKKLEEEKAEAAEAA 989
E L ++++EE EAA
Sbjct: 1382 --AKAQAEREAKELQQRMQEEVVRREEAA 1408
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 59.3 bits (142), Expect = 2e-08
Identities = 65/295 (22%), Positives = 134/295 (45%), Gaps = 21/295 (7%)
Query: 711 QHALRNRRLL------RKVIKAAALEEHNAAMKDQLKLQ-EKDIQMWKVSLQKEQARYNQ 763
Q A R R+L ++ + L+E A+++ +L+ E ++ + L +EQAR +
Sbjct: 2256 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR--R 2313
Query: 764 LQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCH 823
LQE ++ M +L + + Q E + E+ + E + +AE+ +A
Sbjct: 2314 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2373
Query: 824 TELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVE-MMKA 882
++ +KL +E Q+ L + L + + ++ E+L+ ++ +E E + +
Sbjct: 2374 FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE 2433
Query: 883 AYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQA----R 938
A +L+ +QQ Q L +Q +S L++KD LL++++++E K + +
Sbjct: 2434 AKLLQLKSEEMQTVQQEQLLQETQAL---QQSFLSEKDS-LLQRERFIEQEKAKLEQLFQ 2489
Query: 939 GQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLLKKLEEEKAEAAEAAEERL 993
++ A+ E Q+R Q E E L +E+ ++ + E E +E L
Sbjct: 2490 DEVAKAQQLREEQQRQQQQMEQERQRLVASMEE---ARRRQHEAEEGVRRKQEEL 2541
Score = 47.8 bits (112), Expect = 6e-05
Identities = 62/307 (20%), Positives = 131/307 (42%), Gaps = 30/307 (9%)
Query: 705 ERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLK----LQEKDIQMWKVSLQKEQAR 760
ER +RQ R+ +V A+ ++ A +++ + L+E +Q + + QA
Sbjct: 1465 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1524
Query: 761 YNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNK 820
+ ++ + + T S +LQ R F ++ +L+ L++ +A+LR E ++ +
Sbjct: 1525 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1584
Query: 821 VCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVE-- 878
E + ++L + + L Q + + L + + + + +E
Sbjct: 1585 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1644
Query: 879 --------MMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYL 930
+ +ELEK R Q+ +++ ++ L + + + +Q++ L
Sbjct: 1645 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE----QQRQLL 1700
Query: 931 EDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLL---KKLEEEKAEAAE 987
E+ AR Q +AA + QKR Q E E+ + R E + LL + EEE +E
Sbjct: 1701 EEE--LARLQREAAAA---TQKR--QELEAELAKV--RAEMEVLLASKARAEEESRSTSE 1751
Query: 988 AAEERLD 994
+++RL+
Sbjct: 1752 KSKQRLE 1758
Score = 46.2 bits (108), Expect = 2e-04
Identities = 72/315 (22%), Positives = 131/315 (41%), Gaps = 38/315 (12%)
Query: 711 QHALRNRRLLRKVIKAA-ALEEHNAAMKDQLKLQ-------EKDIQMWKVSLQKEQARYN 762
+ LR RR + + I A A E AA K +L+L+ +D K + E AR
Sbjct: 1882 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1941
Query: 763 QLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVC 822
QL + + + ++++ EE Q + ++E + + E R ++A +
Sbjct: 1942 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2001
Query: 823 HTELLLSQVSQKLSNSE------SVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTK- 875
L + +QK +E +VQQ+ + L + L + + L+QL+ + +
Sbjct: 2002 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL----QQEQSVLDQLRGEAEAARRA 2057
Query: 876 --EVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDV 933
E E + +E ++R V ++ +RL S + + + L ++ +
Sbjct: 2058 AEEAEEARVQAEREAAQSRRQV-EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2116
Query: 934 KLQARG----QLQAAESRYEAQKRITQV-------FELEILDLYGRLEKDGLLKKLEEE- 981
+ QA Q QAA++ E K+ + E E+ L +LE+ K L +E
Sbjct: 2117 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2176
Query: 982 ----KAEAAEAAEER 992
KAEA EAA +R
Sbjct: 2177 LQRLKAEATEAARQR 2191
Score = 45.4 bits (106), Expect = 3e-04
Identities = 40/159 (25%), Positives = 75/159 (47%), Gaps = 18/159 (11%)
Query: 685 SDEIRTLRDQLLLLHNQLLYERFKRQQHAL--RNRRLLRKVIKAAALEEHNAAMKDQLKL 742
S+E++T++ + LL Q L + F ++ +L R R + ++ K L + A QL+
Sbjct: 2441 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLR- 2499
Query: 743 QEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLED 802
+++Q + Q++++R +V + + R+ QH+ EE + QE +LE
Sbjct: 2500 ------------EEQQRQQQQMEQERQRLVASME-EARRRQHEAEEGVRRKQEELQQLEQ 2546
Query: 803 CRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESV 841
R EL E + + +LL Q L++SE V
Sbjct: 2547 QRRQQEELLAEENQRLRE--QLQLLEEQHRAALAHSEEV 2583
Score = 37.7 bits (86), Expect = 0.064
Identities = 63/292 (21%), Positives = 119/292 (40%), Gaps = 38/292 (13%)
Query: 706 RFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQLQ 765
R ++Q A R R + ++ L+ + A +L+LQ +++ K Q E + +
Sbjct: 1581 RAQQQAEAERAREEAERELERWQLKANEAL---RLRLQAEEVAQQKSLAQAEAEKQKEEA 1637
Query: 766 EQRDTMVTKLHSQ-IRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHT 824
E+ K Q +RQ + +E Q Q +AE + + A +
Sbjct: 1638 EREARRRGKAEEQAVRQRELAEQELEKQRQ------------LAEGTAQQRLAAEQ---- 1681
Query: 825 ELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTK---EVEMMK 881
++ + + +E +QQ + L +L L ++ Q ++ K E+E++
Sbjct: 1682 -----ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1736
Query: 882 AAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQL 941
A+ + E++RS + QRL+ R EL A+ L E K+ + +
Sbjct: 1737 ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ------RQLAEE 1790
Query: 942 QAAESRYEAQKRITQVFELEILDLYGRL--EKDGLLKKLEEEKAEAAEAAEE 991
AA R EA++ + + +L + RL E + LK+ E E AE+
Sbjct: 1791 DAARQRAEAERVLAE--KLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1840
Score = 33.9 bits (76), Expect = 0.93
Identities = 49/269 (18%), Positives = 108/269 (40%), Gaps = 52/269 (19%)
Query: 743 QEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLED 802
++ +++ W+ + + R+ + Q D +L RQL++ RE + L L+D
Sbjct: 1138 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE----SADPLGAWLQD 1193
Query: 803 CRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELY 862
R +++ + L++S++V++Q+ RQ L E E +
Sbjct: 1194 ARRRQEQIQ--------------------AMPLADSQAVREQL----RQEQALLEEIERH 1229
Query: 863 LEQLQ------NKHSDTTKEVEMMKAAYRKELE------------KNRSHVLQQTQRLDT 904
E+++ ++ + K+ E+ Y+ +LE V+Q+ L T
Sbjct: 1230 GEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRT 1289
Query: 905 SQKRILELESH----LAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFEL 960
+ L S +++ + E+++ E + + R +L E+ E Q+++ +
Sbjct: 1290 HYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQ 1349
Query: 961 EILDLYGRLEKDGLLKKLEEEKAEAAEAA 989
E L ++++EE EAA
Sbjct: 1350 --AKAQAEREAKELQQRMQEEVVRREEAA 1376
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 59.3 bits (142), Expect = 2e-08
Identities = 65/295 (22%), Positives = 134/295 (45%), Gaps = 21/295 (7%)
Query: 711 QHALRNRRLL------RKVIKAAALEEHNAAMKDQLKLQ-EKDIQMWKVSLQKEQARYNQ 763
Q A R R+L ++ + L+E A+++ +L+ E ++ + L +EQAR +
Sbjct: 2425 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR--R 2482
Query: 764 LQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCH 823
LQE ++ M +L + + Q E + E+ + E + +AE+ +A
Sbjct: 2483 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2542
Query: 824 TELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVE-MMKA 882
++ +KL +E Q+ L + L + + ++ E+L+ ++ +E E + +
Sbjct: 2543 FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE 2602
Query: 883 AYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQA----R 938
A +L+ +QQ Q L +Q +S L++KD LL++++++E K + +
Sbjct: 2603 AKLLQLKSEEMQTVQQEQLLQETQAL---QQSFLSEKDS-LLQRERFIEQEKAKLEQLFQ 2658
Query: 939 GQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLLKKLEEEKAEAAEAAEERL 993
++ A+ E Q+R Q E E L +E+ ++ + E E +E L
Sbjct: 2659 DEVAKAQQLREEQQRQQQQMEQERQRLVASMEE---ARRRQHEAEEGVRRKQEEL 2710
Score = 47.8 bits (112), Expect = 6e-05
Identities = 62/307 (20%), Positives = 131/307 (42%), Gaps = 30/307 (9%)
Query: 705 ERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLK----LQEKDIQMWKVSLQKEQAR 760
ER +RQ R+ +V A+ ++ A +++ + L+E +Q + + QA
Sbjct: 1634 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1693
Query: 761 YNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNK 820
+ ++ + + T S +LQ R F ++ +L+ L++ +A+LR E ++ +
Sbjct: 1694 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1753
Query: 821 VCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVE-- 878
E + ++L + + L Q + + L + + + + +E
Sbjct: 1754 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1813
Query: 879 --------MMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYL 930
+ +ELEK R Q+ +++ ++ L + + + +Q++ L
Sbjct: 1814 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE----QQRQLL 1869
Query: 931 EDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLL---KKLEEEKAEAAE 987
E+ AR Q +AA + QKR Q E E+ + R E + LL + EEE +E
Sbjct: 1870 EEE--LARLQREAAAA---TQKR--QELEAELAKV--RAEMEVLLASKARAEEESRSTSE 1920
Query: 988 AAEERLD 994
+++RL+
Sbjct: 1921 KSKQRLE 1927
Score = 46.2 bits (108), Expect = 2e-04
Identities = 72/315 (22%), Positives = 131/315 (41%), Gaps = 38/315 (12%)
Query: 711 QHALRNRRLLRKVIKAA-ALEEHNAAMKDQLKLQ-------EKDIQMWKVSLQKEQARYN 762
+ LR RR + + I A A E AA K +L+L+ +D K + E AR
Sbjct: 2051 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 2110
Query: 763 QLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVC 822
QL + + + ++++ EE Q + ++E + + E R ++A +
Sbjct: 2111 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2170
Query: 823 HTELLLSQVSQKLSNSE------SVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTK- 875
L + +QK +E +VQQ+ + L + L + + L+QL+ + +
Sbjct: 2171 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL----QQEQSVLDQLRGEAEAARRA 2226
Query: 876 --EVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDV 933
E E + +E ++R V ++ +RL S + + + L ++ +
Sbjct: 2227 AEEAEEARVQAEREAAQSRRQV-EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2285
Query: 934 KLQARG----QLQAAESRYEAQKRITQV-------FELEILDLYGRLEKDGLLKKLEEE- 981
+ QA Q QAA++ E K+ + E E+ L +LE+ K L +E
Sbjct: 2286 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2345
Query: 982 ----KAEAAEAAEER 992
KAEA EAA +R
Sbjct: 2346 LQRLKAEATEAARQR 2360
Score = 45.4 bits (106), Expect = 3e-04
Identities = 40/159 (25%), Positives = 75/159 (47%), Gaps = 18/159 (11%)
Query: 685 SDEIRTLRDQLLLLHNQLLYERFKRQQHAL--RNRRLLRKVIKAAALEEHNAAMKDQLKL 742
S+E++T++ + LL Q L + F ++ +L R R + ++ K L + A QL+
Sbjct: 2610 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLR- 2668
Query: 743 QEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLED 802
+++Q + Q++++R +V + + R+ QH+ EE + QE +LE
Sbjct: 2669 ------------EEQQRQQQQMEQERQRLVASME-EARRRQHEAEEGVRRKQEELQQLEQ 2715
Query: 803 CRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESV 841
R EL E + + +LL Q L++SE V
Sbjct: 2716 QRRQQEELLAEENQRLRE--QLQLLEEQHRAALAHSEEV 2752
Score = 37.7 bits (86), Expect = 0.064
Identities = 63/292 (21%), Positives = 119/292 (40%), Gaps = 38/292 (13%)
Query: 706 RFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQLQ 765
R ++Q A R R + ++ L+ + A +L+LQ +++ K Q E + +
Sbjct: 1750 RAQQQAEAERAREEAERELERWQLKANEAL---RLRLQAEEVAQQKSLAQAEAEKQKEEA 1806
Query: 766 EQRDTMVTKLHSQ-IRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHT 824
E+ K Q +RQ + +E Q Q +AE + + A +
Sbjct: 1807 EREARRRGKAEEQAVRQRELAEQELEKQRQ------------LAEGTAQQRLAAEQ---- 1850
Query: 825 ELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTK---EVEMMK 881
++ + + +E +QQ + L +L L ++ Q ++ K E+E++
Sbjct: 1851 -----ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1905
Query: 882 AAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQL 941
A+ + E++RS + QRL+ R EL A+ L E K+ + +
Sbjct: 1906 ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ------RQLAEE 1959
Query: 942 QAAESRYEAQKRITQVFELEILDLYGRL--EKDGLLKKLEEEKAEAAEAAEE 991
AA R EA++ + + +L + RL E + LK+ E E AE+
Sbjct: 1960 DAARQRAEAERVLAE--KLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 2009
Score = 33.9 bits (76), Expect = 0.93
Identities = 49/269 (18%), Positives = 108/269 (40%), Gaps = 52/269 (19%)
Query: 743 QEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLED 802
++ +++ W+ + + R+ + Q D +L RQL++ RE + L L+D
Sbjct: 1307 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE----SADPLGAWLQD 1362
Query: 803 CRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELY 862
R +++ + L++S++V++Q+ RQ L E E +
Sbjct: 1363 ARRRQEQIQ--------------------AMPLADSQAVREQL----RQEQALLEEIERH 1398
Query: 863 LEQLQ------NKHSDTTKEVEMMKAAYRKELE------------KNRSHVLQQTQRLDT 904
E+++ ++ + K+ E+ Y+ +LE V+Q+ L T
Sbjct: 1399 GEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRT 1458
Query: 905 SQKRILELESH----LAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFEL 960
+ L S +++ + E+++ E + + R +L E+ E Q+++ +
Sbjct: 1459 HYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQ 1518
Query: 961 EILDLYGRLEKDGLLKKLEEEKAEAAEAA 989
E L ++++EE EAA
Sbjct: 1519 --AKAQAEREAKELQQRMQEEVVRREEAA 1545
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 59.3 bits (142), Expect = 2e-08
Identities = 65/295 (22%), Positives = 134/295 (45%), Gaps = 21/295 (7%)
Query: 711 QHALRNRRLL------RKVIKAAALEEHNAAMKDQLKLQ-EKDIQMWKVSLQKEQARYNQ 763
Q A R R+L ++ + L+E A+++ +L+ E ++ + L +EQAR +
Sbjct: 2266 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR--R 2323
Query: 764 LQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCH 823
LQE ++ M +L + + Q E + E+ + E + +AE+ +A
Sbjct: 2324 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2383
Query: 824 TELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVE-MMKA 882
++ +KL +E Q+ L + L + + ++ E+L+ ++ +E E + +
Sbjct: 2384 FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE 2443
Query: 883 AYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQA----R 938
A +L+ +QQ Q L +Q +S L++KD LL++++++E K + +
Sbjct: 2444 AKLLQLKSEEMQTVQQEQLLQETQAL---QQSFLSEKDS-LLQRERFIEQEKAKLEQLFQ 2499
Query: 939 GQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLLKKLEEEKAEAAEAAEERL 993
++ A+ E Q+R Q E E L +E+ ++ + E E +E L
Sbjct: 2500 DEVAKAQQLREEQQRQQQQMEQERQRLVASMEE---ARRRQHEAEEGVRRKQEEL 2551
Score = 47.8 bits (112), Expect = 6e-05
Identities = 62/307 (20%), Positives = 131/307 (42%), Gaps = 30/307 (9%)
Query: 705 ERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLK----LQEKDIQMWKVSLQKEQAR 760
ER +RQ R+ +V A+ ++ A +++ + L+E +Q + + QA
Sbjct: 1475 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1534
Query: 761 YNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNK 820
+ ++ + + T S +LQ R F ++ +L+ L++ +A+LR E ++ +
Sbjct: 1535 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1594
Query: 821 VCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVE-- 878
E + ++L + + L Q + + L + + + + +E
Sbjct: 1595 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1654
Query: 879 --------MMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYL 930
+ +ELEK R Q+ +++ ++ L + + + +Q++ L
Sbjct: 1655 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE----QQRQLL 1710
Query: 931 EDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLL---KKLEEEKAEAAE 987
E+ AR Q +AA + QKR Q E E+ + R E + LL + EEE +E
Sbjct: 1711 EEE--LARLQREAAAA---TQKR--QELEAELAKV--RAEMEVLLASKARAEEESRSTSE 1761
Query: 988 AAEERLD 994
+++RL+
Sbjct: 1762 KSKQRLE 1768
Score = 46.2 bits (108), Expect = 2e-04
Identities = 72/315 (22%), Positives = 131/315 (41%), Gaps = 38/315 (12%)
Query: 711 QHALRNRRLLRKVIKAA-ALEEHNAAMKDQLKLQ-------EKDIQMWKVSLQKEQARYN 762
+ LR RR + + I A A E AA K +L+L+ +D K + E AR
Sbjct: 1892 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1951
Query: 763 QLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVC 822
QL + + + ++++ EE Q + ++E + + E R ++A +
Sbjct: 1952 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2011
Query: 823 HTELLLSQVSQKLSNSE------SVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTK- 875
L + +QK +E +VQQ+ + L + L + + L+QL+ + +
Sbjct: 2012 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL----QQEQSVLDQLRGEAEAARRA 2067
Query: 876 --EVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDV 933
E E + +E ++R V ++ +RL S + + + L ++ +
Sbjct: 2068 AEEAEEARVQAEREAAQSRRQV-EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2126
Query: 934 KLQARG----QLQAAESRYEAQKRITQV-------FELEILDLYGRLEKDGLLKKLEEE- 981
+ QA Q QAA++ E K+ + E E+ L +LE+ K L +E
Sbjct: 2127 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2186
Query: 982 ----KAEAAEAAEER 992
KAEA EAA +R
Sbjct: 2187 LQRLKAEATEAARQR 2201
Score = 45.4 bits (106), Expect = 3e-04
Identities = 40/159 (25%), Positives = 75/159 (47%), Gaps = 18/159 (11%)
Query: 685 SDEIRTLRDQLLLLHNQLLYERFKRQQHAL--RNRRLLRKVIKAAALEEHNAAMKDQLKL 742
S+E++T++ + LL Q L + F ++ +L R R + ++ K L + A QL+
Sbjct: 2451 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLR- 2509
Query: 743 QEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLED 802
+++Q + Q++++R +V + + R+ QH+ EE + QE +LE
Sbjct: 2510 ------------EEQQRQQQQMEQERQRLVASME-EARRRQHEAEEGVRRKQEELQQLEQ 2556
Query: 803 CRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESV 841
R EL E + + +LL Q L++SE V
Sbjct: 2557 QRRQQEELLAEENQRLRE--QLQLLEEQHRAALAHSEEV 2593
Score = 37.7 bits (86), Expect = 0.064
Identities = 63/292 (21%), Positives = 119/292 (40%), Gaps = 38/292 (13%)
Query: 706 RFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQLQ 765
R ++Q A R R + ++ L+ + A +L+LQ +++ K Q E + +
Sbjct: 1591 RAQQQAEAERAREEAERELERWQLKANEAL---RLRLQAEEVAQQKSLAQAEAEKQKEEA 1647
Query: 766 EQRDTMVTKLHSQ-IRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHT 824
E+ K Q +RQ + +E Q Q +AE + + A +
Sbjct: 1648 EREARRRGKAEEQAVRQRELAEQELEKQRQ------------LAEGTAQQRLAAEQ---- 1691
Query: 825 ELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTK---EVEMMK 881
++ + + +E +QQ + L +L L ++ Q ++ K E+E++
Sbjct: 1692 -----ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1746
Query: 882 AAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQL 941
A+ + E++RS + QRL+ R EL A+ L E K+ + +
Sbjct: 1747 ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ------RQLAEE 1800
Query: 942 QAAESRYEAQKRITQVFELEILDLYGRL--EKDGLLKKLEEEKAEAAEAAEE 991
AA R EA++ + + +L + RL E + LK+ E E AE+
Sbjct: 1801 DAARQRAEAERVLAE--KLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1850
Score = 33.9 bits (76), Expect = 0.93
Identities = 49/269 (18%), Positives = 108/269 (40%), Gaps = 52/269 (19%)
Query: 743 QEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLED 802
++ +++ W+ + + R+ + Q D +L RQL++ RE + L L+D
Sbjct: 1148 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE----SADPLGAWLQD 1203
Query: 803 CRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELY 862
R +++ + L++S++V++Q+ RQ L E E +
Sbjct: 1204 ARRRQEQIQ--------------------AMPLADSQAVREQL----RQEQALLEEIERH 1239
Query: 863 LEQLQ------NKHSDTTKEVEMMKAAYRKELE------------KNRSHVLQQTQRLDT 904
E+++ ++ + K+ E+ Y+ +LE V+Q+ L T
Sbjct: 1240 GEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRT 1299
Query: 905 SQKRILELESH----LAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFEL 960
+ L S +++ + E+++ E + + R +L E+ E Q+++ +
Sbjct: 1300 HYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQ 1359
Query: 961 EILDLYGRLEKDGLLKKLEEEKAEAAEAA 989
E L ++++EE EAA
Sbjct: 1360 --AKAQAEREAKELQQRMQEEVVRREEAA 1386
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 59.3 bits (142), Expect = 2e-08
Identities = 65/295 (22%), Positives = 134/295 (45%), Gaps = 21/295 (7%)
Query: 711 QHALRNRRLL------RKVIKAAALEEHNAAMKDQLKLQ-EKDIQMWKVSLQKEQARYNQ 763
Q A R R+L ++ + L+E A+++ +L+ E ++ + L +EQAR +
Sbjct: 2274 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR--R 2331
Query: 764 LQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCH 823
LQE ++ M +L + + Q E + E+ + E + +AE+ +A
Sbjct: 2332 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2391
Query: 824 TELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVE-MMKA 882
++ +KL +E Q+ L + L + + ++ E+L+ ++ +E E + +
Sbjct: 2392 FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE 2451
Query: 883 AYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQA----R 938
A +L+ +QQ Q L +Q +S L++KD LL++++++E K + +
Sbjct: 2452 AKLLQLKSEEMQTVQQEQLLQETQAL---QQSFLSEKDS-LLQRERFIEQEKAKLEQLFQ 2507
Query: 939 GQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLLKKLEEEKAEAAEAAEERL 993
++ A+ E Q+R Q E E L +E+ ++ + E E +E L
Sbjct: 2508 DEVAKAQQLREEQQRQQQQMEQERQRLVASMEE---ARRRQHEAEEGVRRKQEEL 2559
Score = 47.8 bits (112), Expect = 6e-05
Identities = 62/307 (20%), Positives = 131/307 (42%), Gaps = 30/307 (9%)
Query: 705 ERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLK----LQEKDIQMWKVSLQKEQAR 760
ER +RQ R+ +V A+ ++ A +++ + L+E +Q + + QA
Sbjct: 1483 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1542
Query: 761 YNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNK 820
+ ++ + + T S +LQ R F ++ +L+ L++ +A+LR E ++ +
Sbjct: 1543 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1602
Query: 821 VCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVE-- 878
E + ++L + + L Q + + L + + + + +E
Sbjct: 1603 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1662
Query: 879 --------MMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYL 930
+ +ELEK R Q+ +++ ++ L + + + +Q++ L
Sbjct: 1663 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE----QQRQLL 1718
Query: 931 EDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLL---KKLEEEKAEAAE 987
E+ AR Q +AA + QKR Q E E+ + R E + LL + EEE +E
Sbjct: 1719 EEE--LARLQREAAAA---TQKR--QELEAELAKV--RAEMEVLLASKARAEEESRSTSE 1769
Query: 988 AAEERLD 994
+++RL+
Sbjct: 1770 KSKQRLE 1776
Score = 46.2 bits (108), Expect = 2e-04
Identities = 72/315 (22%), Positives = 131/315 (41%), Gaps = 38/315 (12%)
Query: 711 QHALRNRRLLRKVIKAA-ALEEHNAAMKDQLKLQ-------EKDIQMWKVSLQKEQARYN 762
+ LR RR + + I A A E AA K +L+L+ +D K + E AR
Sbjct: 1900 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1959
Query: 763 QLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVC 822
QL + + + ++++ EE Q + ++E + + E R ++A +
Sbjct: 1960 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2019
Query: 823 HTELLLSQVSQKLSNSE------SVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTK- 875
L + +QK +E +VQQ+ + L + L + + L+QL+ + +
Sbjct: 2020 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL----QQEQSVLDQLRGEAEAARRA 2075
Query: 876 --EVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDV 933
E E + +E ++R V ++ +RL S + + + L ++ +
Sbjct: 2076 AEEAEEARVQAEREAAQSRRQV-EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2134
Query: 934 KLQARG----QLQAAESRYEAQKRITQV-------FELEILDLYGRLEKDGLLKKLEEE- 981
+ QA Q QAA++ E K+ + E E+ L +LE+ K L +E
Sbjct: 2135 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2194
Query: 982 ----KAEAAEAAEER 992
KAEA EAA +R
Sbjct: 2195 LQRLKAEATEAARQR 2209
Score = 45.4 bits (106), Expect = 3e-04
Identities = 40/159 (25%), Positives = 75/159 (47%), Gaps = 18/159 (11%)
Query: 685 SDEIRTLRDQLLLLHNQLLYERFKRQQHAL--RNRRLLRKVIKAAALEEHNAAMKDQLKL 742
S+E++T++ + LL Q L + F ++ +L R R + ++ K L + A QL+
Sbjct: 2459 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLR- 2517
Query: 743 QEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLED 802
+++Q + Q++++R +V + + R+ QH+ EE + QE +LE
Sbjct: 2518 ------------EEQQRQQQQMEQERQRLVASME-EARRRQHEAEEGVRRKQEELQQLEQ 2564
Query: 803 CRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESV 841
R EL E + + +LL Q L++SE V
Sbjct: 2565 QRRQQEELLAEENQRLRE--QLQLLEEQHRAALAHSEEV 2601
Score = 37.7 bits (86), Expect = 0.064
Identities = 63/292 (21%), Positives = 119/292 (40%), Gaps = 38/292 (13%)
Query: 706 RFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQLQ 765
R ++Q A R R + ++ L+ + A +L+LQ +++ K Q E + +
Sbjct: 1599 RAQQQAEAERAREEAERELERWQLKANEAL---RLRLQAEEVAQQKSLAQAEAEKQKEEA 1655
Query: 766 EQRDTMVTKLHSQ-IRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHT 824
E+ K Q +RQ + +E Q Q +AE + + A +
Sbjct: 1656 EREARRRGKAEEQAVRQRELAEQELEKQRQ------------LAEGTAQQRLAAEQ---- 1699
Query: 825 ELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTK---EVEMMK 881
++ + + +E +QQ + L +L L ++ Q ++ K E+E++
Sbjct: 1700 -----ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1754
Query: 882 AAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQL 941
A+ + E++RS + QRL+ R EL A+ L E K+ + +
Sbjct: 1755 ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ------RQLAEE 1808
Query: 942 QAAESRYEAQKRITQVFELEILDLYGRL--EKDGLLKKLEEEKAEAAEAAEE 991
AA R EA++ + + +L + RL E + LK+ E E AE+
Sbjct: 1809 DAARQRAEAERVLAE--KLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1858
Score = 33.9 bits (76), Expect = 0.93
Identities = 49/269 (18%), Positives = 108/269 (40%), Gaps = 52/269 (19%)
Query: 743 QEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLED 802
++ +++ W+ + + R+ + Q D +L RQL++ RE + L L+D
Sbjct: 1156 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE----SADPLGAWLQD 1211
Query: 803 CRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELY 862
R +++ + L++S++V++Q+ RQ L E E +
Sbjct: 1212 ARRRQEQIQ--------------------AMPLADSQAVREQL----RQEQALLEEIERH 1247
Query: 863 LEQLQ------NKHSDTTKEVEMMKAAYRKELE------------KNRSHVLQQTQRLDT 904
E+++ ++ + K+ E+ Y+ +LE V+Q+ L T
Sbjct: 1248 GEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRT 1307
Query: 905 SQKRILELESH----LAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFEL 960
+ L S +++ + E+++ E + + R +L E+ E Q+++ +
Sbjct: 1308 HYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQ 1367
Query: 961 EILDLYGRLEKDGLLKKLEEEKAEAAEAA 989
E L ++++EE EAA
Sbjct: 1368 --AKAQAEREAKELQQRMQEEVVRREEAA 1394
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 59.3 bits (142), Expect = 2e-08
Identities = 65/295 (22%), Positives = 134/295 (45%), Gaps = 21/295 (7%)
Query: 711 QHALRNRRLL------RKVIKAAALEEHNAAMKDQLKLQ-EKDIQMWKVSLQKEQARYNQ 763
Q A R R+L ++ + L+E A+++ +L+ E ++ + L +EQAR +
Sbjct: 2315 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR--R 2372
Query: 764 LQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCH 823
LQE ++ M +L + + Q E + E+ + E + +AE+ +A
Sbjct: 2373 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2432
Query: 824 TELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVE-MMKA 882
++ +KL +E Q+ L + L + + ++ E+L+ ++ +E E + +
Sbjct: 2433 FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE 2492
Query: 883 AYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQA----R 938
A +L+ +QQ Q L +Q +S L++KD LL++++++E K + +
Sbjct: 2493 AKLLQLKSEEMQTVQQEQLLQETQAL---QQSFLSEKDS-LLQRERFIEQEKAKLEQLFQ 2548
Query: 939 GQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLLKKLEEEKAEAAEAAEERL 993
++ A+ E Q+R Q E E L +E+ ++ + E E +E L
Sbjct: 2549 DEVAKAQQLREEQQRQQQQMEQERQRLVASMEE---ARRRQHEAEEGVRRKQEEL 2600
Score = 47.8 bits (112), Expect = 6e-05
Identities = 62/307 (20%), Positives = 131/307 (42%), Gaps = 30/307 (9%)
Query: 705 ERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLK----LQEKDIQMWKVSLQKEQAR 760
ER +RQ R+ +V A+ ++ A +++ + L+E +Q + + QA
Sbjct: 1524 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1583
Query: 761 YNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNK 820
+ ++ + + T S +LQ R F ++ +L+ L++ +A+LR E ++ +
Sbjct: 1584 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1643
Query: 821 VCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVE-- 878
E + ++L + + L Q + + L + + + + +E
Sbjct: 1644 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1703
Query: 879 --------MMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYL 930
+ +ELEK R Q+ +++ ++ L + + + +Q++ L
Sbjct: 1704 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE----QQRQLL 1759
Query: 931 EDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLL---KKLEEEKAEAAE 987
E+ AR Q +AA + QKR Q E E+ + R E + LL + EEE +E
Sbjct: 1760 EEE--LARLQREAAAA---TQKR--QELEAELAKV--RAEMEVLLASKARAEEESRSTSE 1810
Query: 988 AAEERLD 994
+++RL+
Sbjct: 1811 KSKQRLE 1817
Score = 46.2 bits (108), Expect = 2e-04
Identities = 72/315 (22%), Positives = 131/315 (41%), Gaps = 38/315 (12%)
Query: 711 QHALRNRRLLRKVIKAA-ALEEHNAAMKDQLKLQ-------EKDIQMWKVSLQKEQARYN 762
+ LR RR + + I A A E AA K +L+L+ +D K + E AR
Sbjct: 1941 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 2000
Query: 763 QLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVC 822
QL + + + ++++ EE Q + ++E + + E R ++A +
Sbjct: 2001 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2060
Query: 823 HTELLLSQVSQKLSNSE------SVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTK- 875
L + +QK +E +VQQ+ + L + L + + L+QL+ + +
Sbjct: 2061 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL----QQEQSVLDQLRGEAEAARRA 2116
Query: 876 --EVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDV 933
E E + +E ++R V ++ +RL S + + + L ++ +
Sbjct: 2117 AEEAEEARVQAEREAAQSRRQV-EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2175
Query: 934 KLQARG----QLQAAESRYEAQKRITQV-------FELEILDLYGRLEKDGLLKKLEEE- 981
+ QA Q QAA++ E K+ + E E+ L +LE+ K L +E
Sbjct: 2176 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2235
Query: 982 ----KAEAAEAAEER 992
KAEA EAA +R
Sbjct: 2236 LQRLKAEATEAARQR 2250
Score = 45.4 bits (106), Expect = 3e-04
Identities = 40/159 (25%), Positives = 75/159 (47%), Gaps = 18/159 (11%)
Query: 685 SDEIRTLRDQLLLLHNQLLYERFKRQQHAL--RNRRLLRKVIKAAALEEHNAAMKDQLKL 742
S+E++T++ + LL Q L + F ++ +L R R + ++ K L + A QL+
Sbjct: 2500 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLR- 2558
Query: 743 QEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLED 802
+++Q + Q++++R +V + + R+ QH+ EE + QE +LE
Sbjct: 2559 ------------EEQQRQQQQMEQERQRLVASME-EARRRQHEAEEGVRRKQEELQQLEQ 2605
Query: 803 CRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESV 841
R EL E + + +LL Q L++SE V
Sbjct: 2606 QRRQQEELLAEENQRLRE--QLQLLEEQHRAALAHSEEV 2642
Score = 37.7 bits (86), Expect = 0.064
Identities = 63/292 (21%), Positives = 119/292 (40%), Gaps = 38/292 (13%)
Query: 706 RFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQLQ 765
R ++Q A R R + ++ L+ + A +L+LQ +++ K Q E + +
Sbjct: 1640 RAQQQAEAERAREEAERELERWQLKANEAL---RLRLQAEEVAQQKSLAQAEAEKQKEEA 1696
Query: 766 EQRDTMVTKLHSQ-IRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHT 824
E+ K Q +RQ + +E Q Q +AE + + A +
Sbjct: 1697 EREARRRGKAEEQAVRQRELAEQELEKQRQ------------LAEGTAQQRLAAEQ---- 1740
Query: 825 ELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTK---EVEMMK 881
++ + + +E +QQ + L +L L ++ Q ++ K E+E++
Sbjct: 1741 -----ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1795
Query: 882 AAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQL 941
A+ + E++RS + QRL+ R EL A+ L E K+ + +
Sbjct: 1796 ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ------RQLAEE 1849
Query: 942 QAAESRYEAQKRITQVFELEILDLYGRL--EKDGLLKKLEEEKAEAAEAAEE 991
AA R EA++ + + +L + RL E + LK+ E E AE+
Sbjct: 1850 DAARQRAEAERVLAE--KLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1899
Score = 33.9 bits (76), Expect = 0.93
Identities = 49/269 (18%), Positives = 108/269 (40%), Gaps = 52/269 (19%)
Query: 743 QEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLED 802
++ +++ W+ + + R+ + Q D +L RQL++ RE + L L+D
Sbjct: 1197 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE----SADPLGAWLQD 1252
Query: 803 CRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELY 862
R +++ + L++S++V++Q+ RQ L E E +
Sbjct: 1253 ARRRQEQIQ--------------------AMPLADSQAVREQL----RQEQALLEEIERH 1288
Query: 863 LEQLQ------NKHSDTTKEVEMMKAAYRKELE------------KNRSHVLQQTQRLDT 904
E+++ ++ + K+ E+ Y+ +LE V+Q+ L T
Sbjct: 1289 GEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRT 1348
Query: 905 SQKRILELESH----LAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFEL 960
+ L S +++ + E+++ E + + R +L E+ E Q+++ +
Sbjct: 1349 HYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQ 1408
Query: 961 EILDLYGRLEKDGLLKKLEEEKAEAAEAA 989
E L ++++EE EAA
Sbjct: 1409 --AKAQAEREAKELQQRMQEEVVRREEAA 1435
>gi|169208018 PREDICTED: similar to Golgin subfamily A member 8-like
protein 2 isoform 3 [Homo sapiens]
Length = 595
Score = 58.2 bits (139), Expect = 5e-08
Identities = 75/344 (21%), Positives = 148/344 (43%), Gaps = 31/344 (9%)
Query: 724 IKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTK---LHSQIR 780
+K + L+ ++K Q K E ++ K + + Q +L+ Q T++ + L++ +
Sbjct: 83 VKISRLKNTIKSLKQQKKQVEHQLEEEKKANNERQKAERELEVQIQTLIIQKEELNTDLY 142
Query: 781 QLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSES 840
++ F +S++L +L+ + + EL++A + V TE + S + +
Sbjct: 143 HMERSLRYFEEESKDLAVRLQHS----LQCKGELERALSAVIATEKKKANQLSSCSKAHT 198
Query: 841 VQQQMEFLNRQLLVLGEVNELY--LEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQ 898
+ + L Q L+ ++ +L +QLQ + + + +E +A + + + K +
Sbjct: 199 EWELEQSLQDQALLKAQLTQLKESFQQLQLERDECAEHIEGERARWHQRMSKMLQEICTL 258
Query: 899 TQRLDTSQKRILELESHLAKKDHLLLEQ-----KKYLEDVKLQ-ARGQLQAAESRYEAQK 952
+ +R+ ELE L+K + + E +V+LQ R +L+ ++Q
Sbjct: 259 KKEKQQDMRRVEELERSLSKLKNQMAEPLPPEPPAVPSEVELQHLRKELERVAGELQSQV 318
Query: 953 RITQVFELEILDLYGRL-EKDGLLKKLEEEKAEAAEAAEERL-------DCCNDGCS--- 1001
+ Q L R+ E++ L+K EE E E + + N+ S
Sbjct: 319 KNNQHISLLNRRQEERIREQEERLRKQEERLQEQHEKLRQLAKPQSVFEELNNENKSTLQ 378
Query: 1002 -DSMVGHNEEASGHNGETKTP---RPSSARGSSGSRGGGGSSSS 1041
+ V +E G ET+T P +ARG G+ G GG SSS
Sbjct: 379 LEQQVKELQEKLGEVKETETSAQKEPEAARGP-GAPGPGGESSS 421
Score = 36.6 bits (83), Expect = 0.14
Identities = 50/236 (21%), Positives = 103/236 (43%), Gaps = 33/236 (13%)
Query: 709 RQQHALRNRRLLRKVIKAAALEEHNAA----------MKDQLKLQEKDIQMWKVSLQKEQ 758
R QH+L+ + L + + A E A + +L+ +D + K L + +
Sbjct: 161 RLQHSLQCKGELERALSAVIATEKKKANQLSSCSKAHTEWELEQSLQDQALLKAQLTQLK 220
Query: 759 ARYNQLQEQRD--------------TMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCR 804
+ QLQ +RD ++K+ +I L+ ++++ + +EL+ L +
Sbjct: 221 ESFQQLQLERDECAEHIEGERARWHQRMSKMLQEICTLKKEKQQDMRRVEELERSLSKLK 280
Query: 805 NMIAE-LRIELKKANNKV--CHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNEL 861
N +AE L E ++V H L +V+ +L + Q + LNR+ E
Sbjct: 281 NQMAEPLPPEPPAVPSEVELQHLRKELERVAGELQSQVKNNQHISLLNRRQEERIREQEE 340
Query: 862 YL----EQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELE 913
L E+LQ +H + +++ ++ + +EL LQ Q++ Q+++ E++
Sbjct: 341 RLRKQEERLQEQH-EKLRQLAKPQSVF-EELNNENKSTLQLEQQVKELQEKLGEVK 394
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 58.2 bits (139), Expect = 5e-08
Identities = 63/280 (22%), Positives = 121/280 (43%), Gaps = 32/280 (11%)
Query: 753 SLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRI 812
SL+ E + Q H+ +Q + +R+ +EL+TKL ++L++
Sbjct: 603 SLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKV 662
Query: 813 ELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSD 872
+ ++ +L+ ++ +K SNS ++ +M QLL L + E E++ S
Sbjct: 663 NMA---HRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLE---EKIVAYSSI 716
Query: 873 TTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLED 932
K E+ +EL + + ++T ++I L AKK H LEQ K +E
Sbjct: 717 AAKNAEL-----EQELMEKNEKIRSLETNINTEHEKIC-LAFEKAKKIH--LEQHKEMEK 768
Query: 933 VKLQARGQLQAAESRYEAQKRITQVFELEI------LDLYGRL--EKDGLLKKLEEEKAE 984
+ QL+ + +++ Q++ + + +I L+ RL E G +KK +K E
Sbjct: 769 QIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDE 828
Query: 985 AAEAAE----------ERLDCCNDGCSDSMVGHNEEASGH 1014
A +A + +LD + C + +V H + G+
Sbjct: 829 ALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGN 868
Score = 55.1 bits (131), Expect = 4e-07
Identities = 91/411 (22%), Positives = 165/411 (40%), Gaps = 53/411 (12%)
Query: 629 KKAKGNTEEDGVPSTSPMEVLDRLIQQGADAHSKELNK----LPLPSKSVDWTHFGGSPP 684
+K ++D + +E LDRL+ + KE K L V
Sbjct: 788 EKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQL 847
Query: 685 SDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAA-MKDQLKLQ 743
+ +++L+L NQL + K ++ + + + K ++ H+ +Q +
Sbjct: 848 DSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVIL 907
Query: 744 EKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLED- 802
+ +Q + LQ+E R +L++ + TKL Q+ +L+ + ++ S E K+E+
Sbjct: 908 QHTLQQQQQMLQQETIRNGELEDTQ----TKLEKQVSKLEQELQKQRESSAEKLRKMEEK 963
Query: 803 CRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELY 862
C + E ++ +K + ++ Q +++++ L R GE ++
Sbjct: 964 CESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRD----GENKAMH 1019
Query: 863 LEQLQ----------NKHSDTTKEVEMMKAAYRKEL------------EKNRSH-----V 895
L QL K ++ KE+E ++ + EL E +H
Sbjct: 1020 LSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKST 1079
Query: 896 LQQTQRL-DTSQKRILELESHLAKKDHL---LLEQKKYLEDVKLQARGQLQAAESR-YEA 950
L+Q Q L D QK L LE L L E K +ED K + QA + R +E
Sbjct: 1080 LRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWEL 1139
Query: 951 QKRITQVFELE--ILDLYGRLEK-----DGLLKKLEEEKAEAAEAAEERLD 994
++R QV L+ I + G +E+ +G L+K E E E + E D
Sbjct: 1140 KQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLND 1190
Score = 52.8 bits (125), Expect = 2e-06
Identities = 63/283 (22%), Positives = 126/283 (44%), Gaps = 27/283 (9%)
Query: 693 DQLLLLHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQE--KDIQMW 750
DQ L N L +R + H R R ++ ++ K +L+L+E K I+
Sbjct: 1129 DQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESL 1188
Query: 751 KVSLQ--KEQARYNQ-LQEQRDTMVTKLHSQIRQLQHDREEFYN----QSQELQTKLEDC 803
LQ KEQ R + + Q + +++L +I + Q +E + Q Q + T+ ++
Sbjct: 1189 NDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEA 1248
Query: 804 RNMIAELRIELKKANNKVCHTELL------------LSQVSQKLSNSESVQQQMEFLNRQ 851
++ ELR+ ++ N HTEL + ++S +L + + + ++ +
Sbjct: 1249 IDLGQELRLTREQVQNS--HTELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNH 1306
Query: 852 L---LVLGEVNELYLE-QLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQK 907
L L +V E +LE ++Q + + EVE +K AY E+ ++ + + D+ +
Sbjct: 1307 LAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKS 1366
Query: 908 RILELESHLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEA 950
+ +L L K L E + + ++ Q + + + E+ EA
Sbjct: 1367 SVQQLNEQLEKAKLELEEAQDTVSNLHQQVQDRNEVIEAANEA 1409
Score = 51.2 bits (121), Expect = 6e-06
Identities = 83/393 (21%), Positives = 164/393 (41%), Gaps = 67/393 (17%)
Query: 639 GVPSTSPMEVLDRLIQQGADAHSKELNKLPLPSKSVDWTHFGGSPPSD-EIRTLRDQL-- 695
G+ + SP E + ++ D K +K+ F S P D EI++LR++L
Sbjct: 192 GLLNYSPYENVCKISGSSTDFQKKPRDKM-----------FSSSAPVDQEIKSLREKLNK 240
Query: 696 -------LLLHNQLLYERFKRQQHALRNRRLLRKVIKAAA--------LEEHNAAMKDQL 740
L+ N L +F+ L R ++++A LEE ++ ++
Sbjct: 241 LRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVPILEEQIINLEAEV 300
Query: 741 KLQEKDI--------QMWKVSLQKEQARYNQLQEQRDTMVTKLHS--QIRQLQHDREEFY 790
Q+K + Q K+ ++KEQ+ +E V L Q ++ + R E
Sbjct: 301 SAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAERQRNEAL 360
Query: 791 NQSQELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNR 850
++EL + + +AE ++E +A ++ L + K +Q++
Sbjct: 361 YNAEELSKAFQQYKKKVAE-KLEKVQAEEEILERNLTNCEKENK-----RLQERCGLYKS 414
Query: 851 QLLVLGEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRIL 910
+L +L E L QL+ ++++ +++ +M KN + Q T+ S++ IL
Sbjct: 415 ELEILKEK----LRQLKEENNNGKEKLRIMAV-------KNSEVMAQLTE----SRQSIL 459
Query: 911 ELESHLAKKDHLLLEQKKYLED-----VKLQARGQ-LQAAESRYEAQKRITQVFELEILD 964
+LES L KD +L ++ + + V++ A+ + L + E+ + + E I
Sbjct: 460 KLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQ 519
Query: 965 LYGRLEKDGLLKKLEEEKAEAAEAAEER-LDCC 996
L + E G L + + + E+R + CC
Sbjct: 520 LPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCC 552
Score = 48.9 bits (115), Expect = 3e-05
Identities = 62/275 (22%), Positives = 122/275 (44%), Gaps = 25/275 (9%)
Query: 729 LEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREE 788
LE+ A+K+ KLQ +LQK + +LQ +L S +RQLQ R+
Sbjct: 1034 LEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHG----ELKSTLRQLQELRDV 1089
Query: 789 FYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLS--NSESVQQQME 846
Q+ Q LE+ I +L EL++ ++ + L ++ Q L N E Q+ +
Sbjct: 1090 L----QKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQ 1145
Query: 847 FLNRQLLV---LGEVN------ELYLEQLQNKHSDTTKEVEMMKAAY---RKELEKNRSH 894
+ + + GE+ E LE+ + + + K++E + +++L +
Sbjct: 1146 VTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFI 1205
Query: 895 VLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQA--RGQLQAAESRYEAQK 952
+LQ Q + +K I + + + + ++ EQ++Y+ +A GQ + +R + Q
Sbjct: 1206 MLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQ-ELRLTREQVQN 1264
Query: 953 RITQVFELEILDLYGRLEKDGLLKKLEEEKAEAAE 987
T++ E + + E + L +LE+ K + E
Sbjct: 1265 SHTELAEARHQQVQAQREIERLSSELEDMKQLSKE 1299
Score = 46.2 bits (108), Expect = 2e-04
Identities = 64/290 (22%), Positives = 123/290 (42%), Gaps = 51/290 (17%)
Query: 704 YERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQ 763
YE+ +RQ+ L K+I+ +E N+ +K + + Q+ + L ++ + ++
Sbjct: 632 YEK-ERQRLVTGIEELRTKLIQ---IEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSK 687
Query: 764 LQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCH 823
L+ + +TK SQ+ L+ EE + K AEL EL + N K+
Sbjct: 688 LESE----MTKKCSQLLTLEKQLEEKIVAYSSIAAKN-------AELEQELMEKNEKIRS 736
Query: 824 TELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVEMMKAA 883
E ++ +K+ L + +++LEQ H + K++E ++A
Sbjct: 737 LETNINTEHEKIC----------------LAFEKAKKIHLEQ----HKEMEKQIERLEA- 775
Query: 884 YRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQLQA 943
+LEK +Q + + Q+ I+ + HL D LL E K ++ ++ L+A
Sbjct: 776 ---QLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKA 832
Query: 944 AESRYEAQ----KRITQVFE-------LEILDLYGRLEK-DGLLKKLEEE 981
+++ + +++ E L + L G EK + LKK EE
Sbjct: 833 LQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEE 882
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.130 0.375
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 49,942,739
Number of Sequences: 37866
Number of extensions: 2732421
Number of successful extensions: 18451
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 195
Number of HSP's successfully gapped in prelim test: 1027
Number of HSP's that attempted gapping in prelim test: 13504
Number of HSP's gapped (non-prelim): 4547
length of query: 1164
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1051
effective length of database: 13,968,660
effective search space: 14681061660
effective search space used: 14681061660
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.