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Search of human proteins with 4507465
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4507465 transforming growth factor, beta 3 [Homo sapiens]
(412 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4507465 transforming growth factor, beta 3 [Homo sapiens] 857 0.0
gi|4507463 transforming growth factor, beta 2 isoform 2 [Homo sa... 461 e-130
gi|208022653 transforming growth factor, beta 2 isoform 1 [Homo ... 451 e-127
gi|63025222 transforming growth factor, beta 1 [Homo sapiens] 318 7e-87
gi|4885259 myostatin [Homo sapiens] 117 1e-26
gi|4504699 inhibin beta A precursor [Homo sapiens] 106 3e-23
gi|4502427 bone morphogenetic protein 7 precursor [Homo sapiens] 102 8e-22
gi|4502425 bone morphogenetic protein 6 preproprotein [Homo sapi... 102 8e-22
gi|5031613 growth differentiation factor 11 precursor [Homo sapi... 99 7e-21
gi|157276597 bone morphogenetic protein 4 preproprotein [Homo sa... 97 2e-20
gi|157276595 bone morphogenetic protein 4 preproprotein [Homo sa... 97 2e-20
gi|157276593 bone morphogenetic protein 4 preproprotein [Homo sa... 97 2e-20
gi|4557369 bone morphogenetic protein 2 preproprotein [Homo sapi... 94 3e-19
gi|10835091 bone morphogenetic protein 5 preproprotein [Homo sap... 85 1e-16
gi|13899338 activin beta E [Homo sapiens] 84 2e-16
gi|29571106 bone morphogenetic protein 8B preproprotein [Homo sa... 83 4e-16
gi|145611428 bone morphogenetic protein 8A [Homo sapiens] 83 4e-16
gi|7656928 bone morphogenetic protein 10 preproprotein [Homo sap... 82 1e-15
gi|48475062 growth differentiation factor 6 precursor [Homo sapi... 74 2e-13
gi|61835232 growth differentiation factor 7 preproprotein [Homo ... 72 9e-13
gi|4503969 growth differentiation factor 5 preproprotein [Homo s... 72 1e-12
gi|154813204 inhibin beta B subunit preproprotein [Homo sapiens] 72 1e-12
gi|10190670 growth differentiation factor 3 precursor [Homo sapi... 71 2e-12
gi|5031795 inhibin beta C chain preproprotein [Homo sapiens] 70 3e-12
gi|110349792 growth differentiation factor 1 [Homo sapiens] 68 2e-11
gi|126507087 bone morphogenetic protein 3 preproprotein [Homo sa... 60 3e-09
gi|153792495 growth differentiation factor 15 [Homo sapiens] 60 4e-09
gi|239757187 PREDICTED: similar to growth differentiation factor... 60 4e-09
gi|222352098 nodal precursor [Homo sapiens] 53 6e-07
gi|4885097 bone morphogenetic protein 15 precursor [Homo sapiens] 53 6e-07
>gi|4507465 transforming growth factor, beta 3 [Homo sapiens]
Length = 412
Score = 857 bits (2214), Expect = 0.0
Identities = 412/412 (100%), Positives = 412/412 (100%)
Query: 1 MKMHLQRALVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLTSPPEPT 60
MKMHLQRALVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLTSPPEPT
Sbjct: 1 MKMHLQRALVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLTSPPEPT 60
Query: 61 VMTHVPYQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHKFDMIQGLAEHNEL 120
VMTHVPYQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHKFDMIQGLAEHNEL
Sbjct: 61 VMTHVPYQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHKFDMIQGLAEHNEL 120
Query: 121 AVCPKGITSKVFRFNVSSVEKNRTNLFRAEFRVLRVPNPSSKRNEQRIELFQILRPDEHI 180
AVCPKGITSKVFRFNVSSVEKNRTNLFRAEFRVLRVPNPSSKRNEQRIELFQILRPDEHI
Sbjct: 121 AVCPKGITSKVFRFNVSSVEKNRTNLFRAEFRVLRVPNPSSKRNEQRIELFQILRPDEHI 180
Query: 181 AKQRYIGGKNLPTRGTAEWLSFDVTDTVREWLLRRESNLGLEISIHCPCHTFQPNGDILE 240
AKQRYIGGKNLPTRGTAEWLSFDVTDTVREWLLRRESNLGLEISIHCPCHTFQPNGDILE
Sbjct: 181 AKQRYIGGKNLPTRGTAEWLSFDVTDTVREWLLRRESNLGLEISIHCPCHTFQPNGDILE 240
Query: 241 NIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRLDNPGQGGQRKKR 300
NIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRLDNPGQGGQRKKR
Sbjct: 241 NIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRLDNPGQGGQRKKR 300
Query: 301 ALDTNYCFRNLEENCCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGPCPYLRSADTTHST 360
ALDTNYCFRNLEENCCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGPCPYLRSADTTHST
Sbjct: 301 ALDTNYCFRNLEENCCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGPCPYLRSADTTHST 360
Query: 361 VLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKSCKCS 412
VLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKSCKCS
Sbjct: 361 VLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKSCKCS 412
>gi|4507463 transforming growth factor, beta 2 isoform 2 [Homo
sapiens]
Length = 414
Score = 461 bits (1187), Expect = e-130
Identities = 228/410 (55%), Positives = 294/410 (71%), Gaps = 7/410 (1%)
Query: 9 LVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLTSPPEP-TVMTHVPY 67
L +L+ TV+LSLSTC+TLD +KR+EAIRGQILSKL+LTSPPE VP
Sbjct: 6 LSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVPP 65
Query: 68 QVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHKFDMIQGLAEHNELAVCPKGI 127
+V+++YNSTR+LL+E R C +E ++ EYYAKE++K DM N +
Sbjct: 66 EVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSENAIPPTFYRP 125
Query: 128 TSKVFRFNVSSVEKNRTNLFRAEFRVLRVPNPSSKRNEQRIELFQILRPDEHIAK-QRYI 186
++ RF+VS++EKN +NL +AEFRV R+ NP ++ EQRIEL+QIL+ + + QRYI
Sbjct: 126 YFRIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYQILKSKDLTSPTQRYI 185
Query: 187 GGKNLPTRGTAEWLSFDVTDTVREWLLRRESNLGLEISIHCPCHTFQP-NGDILENIHEV 245
K + TR EWLSFDVTD V EWL ++ NLG +IS+HCPC TF P N I+ N E
Sbjct: 186 DSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEE 245
Query: 246 MEIKFKGVDNEDDHGRGDLGRLK---KQKDHHNPHLILMMIPPHRLDNPGQGGQRKKRAL 302
+E +F G+D + GD +K K+ PHL+LM++P +RL++ Q +RKKRAL
Sbjct: 246 LEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQ-QTNRRKKRAL 304
Query: 303 DTNYCFRNLEENCCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGPCPYLRSADTTHSTVL 362
D YCFRN+++NCC+RPLYIDF++DLGWKW+HEPKGY ANFC+G CPYL S+DT HS VL
Sbjct: 305 DAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVL 364
Query: 363 GLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKSCKCS 412
LYNT+NPEASASPCCV QDLEPLTILYY+G+TPK+EQLSNM+VKSCKCS
Sbjct: 365 SLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS 414
>gi|208022653 transforming growth factor, beta 2 isoform 1 [Homo
sapiens]
Length = 442
Score = 451 bits (1161), Expect = e-127
Identities = 232/441 (52%), Positives = 295/441 (66%), Gaps = 41/441 (9%)
Query: 9 LVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLTSPPEP-TVMTHVPY 67
L +L+ TV+LSLSTC+TLD +KR+EAIRGQILSKL+LTSPPE VP
Sbjct: 6 LSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVPP 65
Query: 68 QVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHKFDMIQGLAEHNELAVCPKGI 127
+V+++YNSTR+LL+E R C +E ++ EYYAKE++K DM VCP
Sbjct: 66 EVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSE---TVCPVVT 122
Query: 128 TS-------------------------------KVFRFNVSSVEKNRTNLFRAEFRVLRV 156
T ++ RF+VS++EKN +NL +AEFRV R+
Sbjct: 123 TPSGSVGSLCSRQSQVLCGYLDAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRL 182
Query: 157 PNPSSKRNEQRIELFQILR-PDEHIAKQRYIGGKNLPTRGTAEWLSFDVTDTVREWLLRR 215
NP ++ EQRIEL+QIL+ D QRYI K + TR EWLSFDVTD V EWL +
Sbjct: 183 QNPKARVPEQRIELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHK 242
Query: 216 ESNLGLEISIHCPCHTFQP-NGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLK---KQK 271
+ NLG +IS+HCPC TF P N I+ N E +E +F G+D + GD +K K+
Sbjct: 243 DRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKN 302
Query: 272 DHHNPHLILMMIPPHRLDNPGQGGQRKKRALDTNYCFRNLEENCCVRPLYIDFRQDLGWK 331
PHL+LM++P +RL++ Q +RKKRALD YCFRN+++NCC+RPLYIDF++DLGWK
Sbjct: 303 SGKTPHLLLMLLPSYRLESQ-QTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWK 361
Query: 332 WVHEPKGYYANFCSGPCPYLRSADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYY 391
W+HEPKGY ANFC+G CPYL S+DT HS VL LYNT+NPEASASPCCV QDLEPLTILYY
Sbjct: 362 WIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYY 421
Query: 392 VGRTPKVEQLSNMVVKSCKCS 412
+G+TPK+EQLSNM+VKSCKCS
Sbjct: 422 IGKTPKIEQLSNMIVKSCKCS 442
>gi|63025222 transforming growth factor, beta 1 [Homo sapiens]
Length = 390
Score = 318 bits (814), Expect = 7e-87
Identities = 190/410 (46%), Positives = 244/410 (59%), Gaps = 40/410 (9%)
Query: 9 LVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLTSPPEPTVMTH--VP 66
L+ L +L + LSTC T+D +K+KR+EAIRGQILSKLRL SPP + +P
Sbjct: 15 LLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLASPPSQGEVPPGPLP 74
Query: 67 YQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHKFDMIQGLAEHNELAVCPKG 126
VLALYNSTR+ + GE E + E++YYAKE+ + M++ HNE+ K
Sbjct: 75 EAVLALYNSTRD---RVAGESAE--PEPEPEADYYAKEVTRVLMVE---THNEIYDKFKQ 126
Query: 127 ITSKVFRF-NVSSVEK---NRTNLFRAEFRVLRVPNPSSKRNEQRIELFQILRPDEHIAK 182
T ++ F N S + + L RAE R+LR+ + EQ +EL+Q +
Sbjct: 127 STHSIYMFFNTSELREAVPEPVLLSRAELRLLRL----KLKVEQHVELYQKYSNNSW--- 179
Query: 183 QRYIGGKNLPTRGTAEWLSFDVTDTVREWLLRRESNLGLEISIHCPCHTFQPNGDILENI 242
RY+ + L + EWLSFDVT VR+WL R G +S HC C D +N
Sbjct: 180 -RYLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSC-------DSRDNT 231
Query: 243 HEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRLDNPGQGGQRKKRAL 302
+V ++ RGDL + + P L+LM P R + R +RAL
Sbjct: 232 LQV------DINGFTTGRRGDLATIHGM---NRPFLLLMATPLERAQH--LQSSRHRRAL 280
Query: 303 DTNYCFRNLEENCCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGPCPYLRSADTTHSTVL 362
DTNYCF + E+NCCVR LYIDFR+DLGWKW+HEPKGY+ANFC GPCPY+ S DT +S VL
Sbjct: 281 DTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVL 340
Query: 363 GLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKSCKCS 412
LYN NP ASA+PCCVPQ LEPL I+YYVGR PKVEQLSNM+V+SCKCS
Sbjct: 341 ALYNQHNPGASAAPCCVPQALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS 390
>gi|4885259 myostatin [Homo sapiens]
Length = 375
Score = 117 bits (294), Expect = 1e-26
Identities = 102/381 (26%), Positives = 169/381 (44%), Gaps = 58/381 (15%)
Query: 36 KKKRVEAIRGQILSKLRLTSPPEPTVMTHVPYQVLALYNSTRELLEEMHGEREEGCTQEN 95
K R+EAI+ QILSKLRL + P + V Q+L REL+++ +R++
Sbjct: 49 KSSRIEAIKIQILSKLRLETAPN--ISKDVIRQLLPKAPPLRELIDQYDVQRDDSSDGSL 106
Query: 96 TESEYYAKEIHKFDMIQGLAEHNELAVCPKGITSKVFRFNVSSVEKNRTNLFRAEFRVLR 155
+ +Y+A + I + ++ + G F S ++ N+ + +
Sbjct: 107 EDDDYHATT----ETIITMPTESDFLMQVDGKPKCCFFKFSSKIQYNKVVKAQLWIYLRP 162
Query: 156 VPNPSSKRNEQRIELFQILRPDEHIAKQRYIGGKNLP---TRGTAEWLSFDVTDTVREWL 212
V P++ +++ ++++P + RY G ++L GT W S DV ++ WL
Sbjct: 163 VETPTTVF----VQILRLIKPMKD--GTRYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWL 216
Query: 213 LRRESNLGLEISIHCPCHTFQPNGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKD 272
+ ESNLG+EI + EN H+ + + F G +D
Sbjct: 217 KQPESNLGIEIKA------------LDENGHD-LAVTFPGPG----------------ED 247
Query: 273 HHNPHLILMMIPPHRLDNPGQGGQRKKRALDTNYCFRNLEENCCVRPLYIDFRQDLGWKW 332
NP L + + D P +R +R + + E CC PL +DF + GW W
Sbjct: 248 GLNPFLEVKVT-----DTP----KRSRRDFGLDCDEHSTESRCCRYPLTVDF-EAFGWDW 297
Query: 333 VHEPKGYYANFCSGPCPYLRSADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYYV 392
+ PK Y AN+CSG C ++ H+ L + NP SA PCC P + P+ +LY+
Sbjct: 298 IIAPKRYKANYCSGECEFVFLQKYPHT---HLVHQANPRGSAGPCCTPTKMSPINMLYFN 354
Query: 393 GRTPKV-EQLSNMVVKSCKCS 412
G+ + ++ MVV C CS
Sbjct: 355 GKEQIIYGKIPAMVVDRCGCS 375
>gi|4504699 inhibin beta A precursor [Homo sapiens]
Length = 426
Score = 106 bits (265), Expect = 3e-23
Identities = 101/407 (24%), Positives = 180/407 (44%), Gaps = 51/407 (12%)
Query: 31 DFGHIKKKRVEAIRGQILSKLRLTSPPEPTVMTHVPYQVLALYNSTRELLEEMHGEREEG 90
D + + + VEA++ IL+ L L P+ T P AL N+ R+L G
Sbjct: 46 DVPNSQPEMVEAVKKHILNMLHLKKRPDVTQ----PVPKAALLNAIRKL--------HVG 93
Query: 91 CTQENTESEYYAKEIHKFDMIQGLAEHNELAV-CPKGITSKVFRFNVSSVEKNRTNLFRA 149
EN E + +M + + + +E+ G K F +S + + + RA
Sbjct: 94 KVGENGYVEIEDDIGRRAEMNELMEQTSEIITFAESGTARKTLHFEISKEGSDLSVVERA 153
Query: 150 E-FRVLRVPNPSSKRNEQRIELFQILRPDEHIA--------------KQRYIGGKNLPTR 194
E + L+VP + R + I LFQ + + + + + +
Sbjct: 154 EVWLFLKVPKANRTRTKVTIRLFQQQKHPQGSLDTGEEAEEVGLKGERSELLLSEKVVDA 213
Query: 195 GTAEWLSFDVTDTVREWLLRRESNLGLEISIHCPCHTFQPNGDILENIHEVMEIKFKGVD 254
+ W F V+ +++ L + +S+L + I+ C Q +G L + + + + +G
Sbjct: 214 RKSTWHVFPVSSSIQRLLDQGKSSLDVRIA----CEQCQESGASLVLLGKKKKKEEEGEG 269
Query: 255 NEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRLDNPGQGGQRKKRALDTNYCFRNLEEN 314
+ G G G ++++ H P L+L D+P + R++R L+ +
Sbjct: 270 KKKGGGEGGAGADEEKEQSHRPFLMLQARQSE--DHPHR---RRRRGLECD----GKVNI 320
Query: 315 CCVRPLYIDFRQDLGWK-WVHEPKGYYANFCSGPCP-----YLRSADTTHSTVLGLYNTL 368
CC + ++ F+ D+GW W+ P GY+AN+C G CP S+ + HSTV+ Y
Sbjct: 321 CCKKQFFVSFK-DIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMR 379
Query: 369 --NPEASASPCCVPQDLEPLTILYY-VGRTPKVEQLSNMVVKSCKCS 412
+P A+ CCVP L P+++LYY G+ + + NM+V+ C CS
Sbjct: 380 GHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS 426
>gi|4502427 bone morphogenetic protein 7 precursor [Homo sapiens]
Length = 431
Score = 102 bits (253), Expect = 8e-22
Identities = 105/440 (23%), Positives = 182/440 (41%), Gaps = 70/440 (15%)
Query: 12 LALLNFATVSLSLSTCTTLDFGH--IKKKRVEAIRGQILSKLRLTSPPEPTVM---THVP 66
L LL A SL F H ++ + ++ +ILS L L P P + P
Sbjct: 21 LFLLRSALADFSLDNEVHSSFIHRRLRSQERREMQREILSILGLPHRPRPHLQGKHNSAP 80
Query: 67 YQVLALYNSTRELLEEMHGEREEGCTQE-------------NTESEYYAKEIHKFDMIQG 113
+L LYN+ +EE G +G + + + ++ +
Sbjct: 81 MFMLDLYNAMA--VEEGGGPGGQGFSYPYKAVFSTQGPPLASLQDSHFLTDADMVMSFVN 138
Query: 114 LAEHNELAVCPKGITSKVFRFNVSSVEKNRTNLFRAEFRVLRVPNPSSKRNEQ-RIELFQ 172
L EH++ P+ + FRF++S + + + AEFR+ + NE RI ++Q
Sbjct: 139 LVEHDKEFFHPR-YHHREFRFDLSKIPEGEA-VTAAEFRIYKDYIRERFDNETFRISVYQ 196
Query: 173 ILRPDEHIAKQRYIGGKNLPTRGTAE--WLSFDVTDTVREWLLRRESNLGLEISIHC--- 227
+L+ EH+ ++ + + T +E WL FD+T T W++ NLGL++S+
Sbjct: 197 VLQ--EHLGRESDLFLLDSRTLWASEEGWLVFDITATSNHWVVNPRHNLGLQLSVETLDG 254
Query: 228 -----------PCHTFQPNGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNP 276
H Q + + E+ F+ + + R + K N
Sbjct: 255 QSINPKLAGLIGRHGPQNKQPFMVAFFKATEVHFRSIRSTGSKQRSQ----NRSKTPKNQ 310
Query: 277 HLILMMIPPHRLDNPGQGGQRKKRALDTNYCFRNLEENCCVRPLYIDFRQDLGWK-WVHE 335
+ R+ N + +R + C LY+ FR DLGW+ W+
Sbjct: 311 EAL-------RMANVAENSSSDQR------------QACKKHELYVSFR-DLGWQDWIIA 350
Query: 336 PKGYYANFCSGPCPYLRSA---DTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYYV 392
P+GY A +C G C + ++ T H+ V L + +NPE PCC P L +++LY+
Sbjct: 351 PEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPETVPKPCCAPTQLNAISVLYFD 410
Query: 393 GRTPKV-EQLSNMVVKSCKC 411
+ + ++ NMVV++C C
Sbjct: 411 DSSNVILKKYRNMVVRACGC 430
>gi|4502425 bone morphogenetic protein 6 preproprotein [Homo
sapiens]
Length = 513
Score = 102 bits (253), Expect = 8e-22
Identities = 78/296 (26%), Positives = 131/296 (44%), Gaps = 21/296 (7%)
Query: 124 PKGITSKVFRFNVSSVEKNRTNLFRAEFRVLRVPNPSSKRNEQ-RIELFQILRPDEHIAK 182
P+ K F+FN+S + + + AEFR+ + S +N+ I ++Q+L+ +H
Sbjct: 230 PRQRHHKEFKFNLSQIPEGEV-VTAAEFRIYKDCVMGSFKNQTFLISIYQVLQEHQHRDS 288
Query: 183 QRYIGGKNLPTRGTAEWLSFDVTDTVREWLLRRESNLGLEISIHCPCHTFQPNGDILENI 242
++ + WL FD+T T W++ + N+GL++S+ + +
Sbjct: 289 DLFLLDTRVVWASEEGWLEFDITATSNLWVVTPQHNMGLQLSVVTR-----------DGV 337
Query: 243 H-EVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRLDNPGQGGQRKKRA 301
H G D D + K + H + N Q R
Sbjct: 338 HVHPRAAGLVGRDGPYDKQPFMVAFFKVSEVHVRTTRSASSRRRQQSRNRSTQSQDVARV 397
Query: 302 LD-TNYCFRNLEENCCVRPLYIDFRQDLGWK-WVHEPKGYYANFCSGPCPYLRSAD---T 356
++Y L+ C LY+ F QDLGW+ W+ PKGY AN+C G C + +A T
Sbjct: 398 SSASDYNSSELKTACRKHELYVSF-QDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNAT 456
Query: 357 THSTVLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKV-EQLSNMVVKSCKC 411
H+ V L + +NPE PCC P L +++LY+ + + ++ NMVV++C C
Sbjct: 457 NHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYFDDNSNVILKKYRNMVVRACGC 512
>gi|5031613 growth differentiation factor 11 precursor [Homo
sapiens]
Length = 407
Score = 99.0 bits (245), Expect = 7e-21
Identities = 104/399 (26%), Positives = 165/399 (41%), Gaps = 81/399 (20%)
Query: 34 HIKKKRVEAIRGQILSKLRLTSPPEPTVMTHVPYQVLALYNSTRELLEEMHGEREEGCTQ 93
H ++ R+E+I+ QILSKLRL P + V Q+L +++L+ +H + +
Sbjct: 70 HSRELRLESIKSQILSKLRLKEAPN--ISREVVKQLLPKAPPLQQILD-LHDFQGDALQP 126
Query: 94 EN--TESEYYAKEIHKFDMIQGLAEHNELAVCPKGITSKVFRFNVSSVEKNRTNLFRAEF 151
E+ E EY+A + + +A+ + AV G + F+ S + T + +A+
Sbjct: 127 EDFLEEDEYHATT----ETVISMAQETDPAVQTDG-SPLCCHFHFSP-KVMFTKVLKAQL 180
Query: 152 RV-LR-VPNPSSKRNEQRIELFQILRPDEHIAKQRYIGG----KNLPTRG--------TA 197
V LR VP P++ QILR + GG +++ R +
Sbjct: 181 WVYLRPVPRPATV-------YLQILRLKPLTGEGTAGGGGGGRRHIRIRSLKIELHSRSG 233
Query: 198 EWLSFDVTDTVREWLLRRESNLGLEISIHCPCHT---FQPNGDILENIHEVMEIKFKGVD 254
W S D + W + +SN G+EI+ P T G E +H ME++
Sbjct: 234 HWQSIDFKQVLHSWFRQPQSNWGIEINAFDPSGTDLAVTSLGPGAEGLHPFMELRV---- 289
Query: 255 NEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRLDNPGQGGQRKKRALDTNYCFRNLEEN 314
L+N +R +R L + + E
Sbjct: 290 ---------------------------------LENT----KRSRRNLGLDCDEHSSESR 312
Query: 315 CCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGPCPYLRSADTTHSTVLGLYNTLNPEASA 374
CC PL +DF + GW W+ PK Y AN+CSG C Y+ H+ L NP SA
Sbjct: 313 CCRYPLTVDF-EAFGWDWIIAPKRYKANYCSGQCEYMFMQKYPHT---HLVQQANPRGSA 368
Query: 375 SPCCVPQDLEPLTILYYVGRTPKV-EQLSNMVVKSCKCS 412
PCC P + P+ +LY+ + + ++ MVV C CS
Sbjct: 369 GPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGCS 407
>gi|157276597 bone morphogenetic protein 4 preproprotein [Homo
sapiens]
Length = 408
Score = 97.4 bits (241), Expect = 2e-20
Identities = 98/384 (25%), Positives = 161/384 (41%), Gaps = 56/384 (14%)
Query: 47 ILSKLRLTSPPEPTVMTHVPYQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIH 106
+L L P+P+ +P + R+L GE EE +T EY +
Sbjct: 61 LLQMFGLRRRPQPSKSAVIP-------DYMRDLYRLQSGEEEEEQIH-STGLEYPERPAS 112
Query: 107 KFDMIQGLAEHNELAVCPKGITSKVFRF--NVSSVEKNRTNLFRAEFRVLRVP---NPSS 161
+ + ++ L P + FRF N+SS+ +N + AE R+ R P
Sbjct: 113 RANTVRSFHHEEHLENIPGTSENSAFRFLFNLSSIPENEV-ISSAELRLFREQVDQGPDW 171
Query: 162 KRNEQRIELFQILRPDEHIAKQRYIGGKNLPTR----GTAEWLSFDVTDTVREWLLRRES 217
+R RI ++++++P + I + L TR W +FDV+ V W ++
Sbjct: 172 ERGFHRINIYEVMKPPAEVVPGHLIT-RLLDTRLVHHNVTRWETFDVSPAVLRWTREKQP 230
Query: 218 NLGLEISIHCPCHTFQPNGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPH 277
N GL I + H Q H+ ++ + G G+ +L+
Sbjct: 231 NYGLAIEV---THLHQTR------THQGQHVR---ISRSLPQGSGNWAQLRP-------- 270
Query: 278 LILMMIPPHRLDNPGQGGQRKKRALDT----NYCFRNLEENCCVRPLYIDFRQDLGWK-W 332
L++ H D G R++RA + + R +NC LY+DF D+GW W
Sbjct: 271 --LLVTFGH--DGRGHALTRRRRAKRSPKHHSQRARKKNKNCRRHSLYVDF-SDVGWNDW 325
Query: 333 VHEPKGYYANFCSGPCPYLRS---ADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTIL 389
+ P GY A +C G CP+ + T H+ V L N++N + CCVP +L +++L
Sbjct: 326 IVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVN-SSIPKACCVPTELSAISML 384
Query: 390 YYVGRTPKV--EQLSNMVVKSCKC 411
Y+ KV + MVV+ C C
Sbjct: 385 -YLDEYDKVVLKNYQEMVVEGCGC 407
>gi|157276595 bone morphogenetic protein 4 preproprotein [Homo
sapiens]
Length = 408
Score = 97.4 bits (241), Expect = 2e-20
Identities = 98/384 (25%), Positives = 161/384 (41%), Gaps = 56/384 (14%)
Query: 47 ILSKLRLTSPPEPTVMTHVPYQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIH 106
+L L P+P+ +P + R+L GE EE +T EY +
Sbjct: 61 LLQMFGLRRRPQPSKSAVIP-------DYMRDLYRLQSGEEEEEQIH-STGLEYPERPAS 112
Query: 107 KFDMIQGLAEHNELAVCPKGITSKVFRF--NVSSVEKNRTNLFRAEFRVLRVP---NPSS 161
+ + ++ L P + FRF N+SS+ +N + AE R+ R P
Sbjct: 113 RANTVRSFHHEEHLENIPGTSENSAFRFLFNLSSIPENEV-ISSAELRLFREQVDQGPDW 171
Query: 162 KRNEQRIELFQILRPDEHIAKQRYIGGKNLPTR----GTAEWLSFDVTDTVREWLLRRES 217
+R RI ++++++P + I + L TR W +FDV+ V W ++
Sbjct: 172 ERGFHRINIYEVMKPPAEVVPGHLIT-RLLDTRLVHHNVTRWETFDVSPAVLRWTREKQP 230
Query: 218 NLGLEISIHCPCHTFQPNGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPH 277
N GL I + H Q H+ ++ + G G+ +L+
Sbjct: 231 NYGLAIEV---THLHQTR------THQGQHVR---ISRSLPQGSGNWAQLRP-------- 270
Query: 278 LILMMIPPHRLDNPGQGGQRKKRALDT----NYCFRNLEENCCVRPLYIDFRQDLGWK-W 332
L++ H D G R++RA + + R +NC LY+DF D+GW W
Sbjct: 271 --LLVTFGH--DGRGHALTRRRRAKRSPKHHSQRARKKNKNCRRHSLYVDF-SDVGWNDW 325
Query: 333 VHEPKGYYANFCSGPCPYLRS---ADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTIL 389
+ P GY A +C G CP+ + T H+ V L N++N + CCVP +L +++L
Sbjct: 326 IVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVN-SSIPKACCVPTELSAISML 384
Query: 390 YYVGRTPKV--EQLSNMVVKSCKC 411
Y+ KV + MVV+ C C
Sbjct: 385 -YLDEYDKVVLKNYQEMVVEGCGC 407
>gi|157276593 bone morphogenetic protein 4 preproprotein [Homo
sapiens]
Length = 408
Score = 97.4 bits (241), Expect = 2e-20
Identities = 98/384 (25%), Positives = 161/384 (41%), Gaps = 56/384 (14%)
Query: 47 ILSKLRLTSPPEPTVMTHVPYQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIH 106
+L L P+P+ +P + R+L GE EE +T EY +
Sbjct: 61 LLQMFGLRRRPQPSKSAVIP-------DYMRDLYRLQSGEEEEEQIH-STGLEYPERPAS 112
Query: 107 KFDMIQGLAEHNELAVCPKGITSKVFRF--NVSSVEKNRTNLFRAEFRVLRVP---NPSS 161
+ + ++ L P + FRF N+SS+ +N + AE R+ R P
Sbjct: 113 RANTVRSFHHEEHLENIPGTSENSAFRFLFNLSSIPENEV-ISSAELRLFREQVDQGPDW 171
Query: 162 KRNEQRIELFQILRPDEHIAKQRYIGGKNLPTR----GTAEWLSFDVTDTVREWLLRRES 217
+R RI ++++++P + I + L TR W +FDV+ V W ++
Sbjct: 172 ERGFHRINIYEVMKPPAEVVPGHLIT-RLLDTRLVHHNVTRWETFDVSPAVLRWTREKQP 230
Query: 218 NLGLEISIHCPCHTFQPNGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPH 277
N GL I + H Q H+ ++ + G G+ +L+
Sbjct: 231 NYGLAIEV---THLHQTR------THQGQHVR---ISRSLPQGSGNWAQLRP-------- 270
Query: 278 LILMMIPPHRLDNPGQGGQRKKRALDT----NYCFRNLEENCCVRPLYIDFRQDLGWK-W 332
L++ H D G R++RA + + R +NC LY+DF D+GW W
Sbjct: 271 --LLVTFGH--DGRGHALTRRRRAKRSPKHHSQRARKKNKNCRRHSLYVDF-SDVGWNDW 325
Query: 333 VHEPKGYYANFCSGPCPYLRS---ADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTIL 389
+ P GY A +C G CP+ + T H+ V L N++N + CCVP +L +++L
Sbjct: 326 IVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVN-SSIPKACCVPTELSAISML 384
Query: 390 YYVGRTPKV--EQLSNMVVKSCKC 411
Y+ KV + MVV+ C C
Sbjct: 385 -YLDEYDKVVLKNYQEMVVEGCGC 407
>gi|4557369 bone morphogenetic protein 2 preproprotein [Homo
sapiens]
Length = 396
Score = 93.6 bits (231), Expect = 3e-19
Identities = 96/382 (25%), Positives = 164/382 (42%), Gaps = 58/382 (15%)
Query: 46 QILSKLRLTSPPEPTVMTHVPYQVLALY--NSTRELLEEMHGEREEGCTQENTESEYYAK 103
++LS L P P+ VP +L LY +S + E ++ NT +
Sbjct: 56 RLLSMFGLKQRPTPSRDAVVPPYMLDLYRRHSGQPGSPAPDHRLERAASRANT-----VR 110
Query: 104 EIHKFDMIQGLAEHNELAVCPKGITSKVFRFNVSSVEKNRTNLFRAEFRVLRVPNPSSKR 163
H + ++ L E + G T++ F FN+SS+ + AE +V R +
Sbjct: 111 SFHHEESLEELPETS-------GKTTRRFFFNLSSIPTEEF-ITSAELQVFREQMQDALG 162
Query: 164 NEQ----RIELFQILRPDEHIAKQRYIGGKNLPTR----GTAEWLSFDVTDTVREWLLRR 215
N RI +++I++P A ++ + L TR + W SFDVT V W +
Sbjct: 163 NNSSFHHRINIYEIIKPAT--ANSKFPVTRLLDTRLVNQNASRWESFDVTPAVMRWTAQG 220
Query: 216 ESNLGLEISIHCPCHTFQPNGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHN 275
+N G + + H + G ++ + ++D+H + L H
Sbjct: 221 HANHGFVVEV---AHLEEKQGVSKRHVRISRSL------HQDEHSWSQIRPLLVTFGHDG 271
Query: 276 PHLILMMIPPHRLDNPGQGGQRKKRALDTNYCFRNLEENCCVRPLYIDFRQDLGWK-WVH 334
P H+ + +++KR L+ +C PLY+DF D+GW W+
Sbjct: 272 KGH-----PLHKREKRQAKHKQRKR----------LKSSCKRHPLYVDF-SDVGWNDWIV 315
Query: 335 EPKGYYANFCSGPCPYLRS---ADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYY 391
P GY+A +C G CP+ + T H+ V L N++N + + CCVP +L +++L Y
Sbjct: 316 APPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNSKIPKA-CCVPTELSAISML-Y 373
Query: 392 VGRTPKV--EQLSNMVVKSCKC 411
+ KV + +MVV+ C C
Sbjct: 374 LDENEKVVLKNYQDMVVEGCGC 395
>gi|10835091 bone morphogenetic protein 5 preproprotein [Homo
sapiens]
Length = 454
Score = 85.1 bits (209), Expect = 1e-16
Identities = 75/303 (24%), Positives = 132/303 (43%), Gaps = 48/303 (15%)
Query: 130 KVFRFNVSSVEKNRTNLFRAEFRVLRVPNPSSKRNEQ-RIELFQILRPDEHIAKQRYIGG 188
K FRF+++ + + AEFR+ + + + NE +I ++QI++ + ++
Sbjct: 178 KEFRFDLTQIPHGEA-VTAAEFRIYKDRSNNRFENETIKISIYQIIKEYTNRDADLFLLD 236
Query: 189 KNLPTRGTAEWLSFDVTDTVREWLLRRESNLGLEISIHCPCHTFQPNGDILENIHEVMEI 248
WL FD+T T W++ ++NLGL++ GD + +
Sbjct: 237 TRKAQALDVGWLVFDITVTSNHWVINPQNNLGLQLCAE--------TGD-----GRSINV 283
Query: 249 KFKGVDNEDDHGRGDLGRLKKQKDHHNPHLIL------MMIPPHRLDNPGQGGQRKKRAL 302
K G+ G G KQ P ++ +++ R N + R K +
Sbjct: 284 KSAGLV-------GRQGPQSKQ-----PFMVAFFKASEVLLRSVRAANKRKNQNRNKSSS 331
Query: 303 DTN---------YCFRNLEENCCVRPLYIDFRQDLGWK-WVHEPKGYYANFCSGPCPYLR 352
+ Y ++ C LY+ FR DLGW+ W+ P+GY A +C G C +
Sbjct: 332 HQDSSRMSSVGDYNTSEQKQACKKHELYVSFR-DLGWQDWIIAPEGYAAFYCDGECSFPL 390
Query: 353 SAD---TTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKV-EQLSNMVVKS 408
+A T H+ V L + + P+ PCC P L +++LY+ + + ++ NMVV+S
Sbjct: 391 NAHMNATNHAIVQTLVHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRS 450
Query: 409 CKC 411
C C
Sbjct: 451 CGC 453
>gi|13899338 activin beta E [Homo sapiens]
Length = 350
Score = 84.3 bits (207), Expect = 2e-16
Identities = 58/159 (36%), Positives = 82/159 (51%), Gaps = 19/159 (11%)
Query: 262 GDLGRLKKQKDHHNPHLILMMIPPHRLDNPGQGGQRKKRALDTNYCFRNLEENCCVRPLY 321
G RL H P L L + R + PG G R++ T C CC R Y
Sbjct: 203 GQPRRLLDTAGHQQPFLELKI----RANEPGAGRARRR----TPTC-EPATPLCCRRDHY 253
Query: 322 IDFRQDLGWK-WVHEPKGYYANFCSGPC-PYLRS----ADTTHSTVLGLYNTLNPEASAS 375
+DF Q+LGW+ W+ +P+GY N+CSG C P+L A + HS V L NP +++
Sbjct: 254 VDF-QELGWRDWILQPEGYQLNYCSGQCPPHLAGSPGIAASFHSAVFSLLKANNPWPAST 312
Query: 376 PCCVPQDLEPLTILY--YVGRTPKVEQLSNMVVKSCKCS 412
CCVP PL++LY + G K + + +MVV++C CS
Sbjct: 313 SCCVPTARRPLSLLYLDHNGNVVKTD-VPDMVVEACGCS 350
>gi|29571106 bone morphogenetic protein 8B preproprotein [Homo
sapiens]
Length = 402
Score = 83.2 bits (204), Expect = 4e-16
Identities = 72/294 (24%), Positives = 118/294 (40%), Gaps = 30/294 (10%)
Query: 130 KVFRFNVSSVEKNRTNLFRAEFRVLRVPNPSSKRNEQRIELFQILRPDEHIAKQRYIGGK 189
K FRF+++ + + AEFR+ +VP+ + +FQ+++ + +
Sbjct: 126 KEFRFDLTQIPAGEA-VTAAEFRIYKVPSIHLLNRTLHVSMFQVVQEQSNRESDLFFLDL 184
Query: 190 NLPTRGTAEWLSFDVTDTVREWLLRRESNLGLEISIHCPC-HTFQPN-----GDILENIH 243
G WL DVT WLL+R +LGL + + H+ P G
Sbjct: 185 QTLRAGDEGWLVLDVTAASDCWLLKRHKDLGLRLYVETEDGHSVDPGLAGLLGQRAPRSQ 244
Query: 244 EVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRLDNP-GQGGQRKKRAL 302
+ + F + L++++ + L P D+ G G++
Sbjct: 245 QPFVVTFFRASPSPIRTPRAVRPLRRRQPKKSNELPQANRLPGIFDDVHGSHGRQV---- 300
Query: 303 DTNYCFRNLEENCCVRPLYIDFRQDLGW-KWVHEPKGYYANFCSGPCPYLRSA---DTTH 358
C LY+ F QDLGW WV P+GY A +C G C + + T H
Sbjct: 301 ------------CRRHELYVSF-QDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNH 347
Query: 359 STVLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKV-EQLSNMVVKSCKC 411
+ + L + + P+A CC P L ++LYY + + NMVVK+C C
Sbjct: 348 AILQSLVHLMMPDAVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGC 401
>gi|145611428 bone morphogenetic protein 8A [Homo sapiens]
Length = 402
Score = 83.2 bits (204), Expect = 4e-16
Identities = 72/294 (24%), Positives = 117/294 (39%), Gaps = 30/294 (10%)
Query: 130 KVFRFNVSSVEKNRTNLFRAEFRVLRVPNPSSKRNEQRIELFQILRPDEHIAKQRYIGGK 189
K FRF+++ + + AEFR+ +VP+ + +FQ+++ + +
Sbjct: 126 KEFRFDLTQIPAGEA-VTAAEFRIYKVPSIHLLNRTLHVSMFQVVQEQSNRESDLFFLDL 184
Query: 190 NLPTRGTAEWLSFDVTDTVREWLLRRESNLGLEISIHCPC-HTFQPN-----GDILENIH 243
G WL DVT WLL+R +LGL + + H+ P G
Sbjct: 185 QTLRAGDEGWLVLDVTAASDCWLLKRHKDLGLRLYVETEDGHSVDPGLAGLLGQRAPRSQ 244
Query: 244 EVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRLDNP-GQGGQRKKRAL 302
+ + F + L++++ + L P D+ G G++
Sbjct: 245 QPFVVTFFRASPSPIRTPRAVRPLRRRQPKKSNELPQANRLPGIFDDVRGSHGRQV---- 300
Query: 303 DTNYCFRNLEENCCVRPLYIDFRQDLGW-KWVHEPKGYYANFCSGPCPYLRSA---DTTH 358
C LY+ F QDLGW WV P+GY A +C G C + + T H
Sbjct: 301 ------------CRRHELYVSF-QDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNH 347
Query: 359 STVLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKV-EQLSNMVVKSCKC 411
+ + L + + P A CC P L ++LYY + + NMVVK+C C
Sbjct: 348 AILQSLVHLMKPNAVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGC 401
>gi|7656928 bone morphogenetic protein 10 preproprotein [Homo
sapiens]
Length = 424
Score = 81.6 bits (200), Expect = 1e-15
Identities = 75/277 (27%), Positives = 116/277 (41%), Gaps = 45/277 (16%)
Query: 165 EQRIELFQILRPDEHIAKQR----YIGGKNLPTRGTAEWLSFDVTDTVREWLLRRESNLG 220
+++I +F++L +R + G+ T +EW +FDVTD +R W S
Sbjct: 162 DRKITIFEVLESKGDNEGERNMLVLVSGEIYGTN--SEWETFDVTDAIRRWQKSGSSTHQ 219
Query: 221 LEISIHCPCHTFQPNGD-------ILENIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDH 273
LE+ I + +N H + I F + D K++K+
Sbjct: 220 LEVHIESKHDEAEDASSGRLEIDTSAQNKHNPLLIVFSDDQSSD----------KERKEE 269
Query: 274 HNPHLILMMIPPHRLDNPGQG------GQRKKRALDTNYCF-------RNLEENCCVR-P 319
N + +P LDN G G+ + +N + RN + N C R P
Sbjct: 270 LNEMISHEQLP--ELDNLGLDSFSSGPGEEALLQMRSNIIYDSTARIRRNAKGNYCKRTP 327
Query: 320 LYIDFRQDLGW-KWVHEPKGYYANFCSGPCPYLRS---ADTTHSTVLGLYNTLNPEASAS 375
LYIDF++ +GW W+ P GY A C G C Y + T H+ + L + N + ++
Sbjct: 328 LYIDFKE-IGWDSWIIAPPGYEAYECRGVCNYPLAEHLTPTKHAIIQALVHLKNSQKASK 386
Query: 376 PCCVPQDLEPLTILYY-VGRTPKVEQLSNMVVKSCKC 411
CCVP LEP++ILY G + M V C C
Sbjct: 387 ACCVPTKLEPISILYLDKGVVTYKFKYEGMAVSECGC 423
>gi|48475062 growth differentiation factor 6 precursor [Homo
sapiens]
Length = 455
Score = 74.3 bits (181), Expect = 2e-13
Identities = 44/129 (34%), Positives = 73/129 (56%), Gaps = 9/129 (6%)
Query: 291 PGQGGQRKKRALDTNYCFRNLEEN---CCVRPLYIDFRQDLGWK-WVHEPKGYYANFCSG 346
P G +R++ A + + R+ +++ C +PL+++F++ LGW W+ P Y A C G
Sbjct: 327 PSPGRRRRRTAFASRHGKRHGKKSRLRCSKKPLHVNFKE-LGWDDWIIAPLEYEAYHCEG 385
Query: 347 PCPY-LRS--ADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYY-VGRTPKVEQLS 402
C + LRS T H+ + L N+++P ++ CCVP L P++ILY G +Q
Sbjct: 386 VCDFPLRSHLEPTNHAIIQTLMNSMDPGSTPPSCCVPTKLTPISILYIDAGNNVVYKQYE 445
Query: 403 NMVVKSCKC 411
+MVV+SC C
Sbjct: 446 DMVVESCGC 454
>gi|61835232 growth differentiation factor 7 preproprotein [Homo
sapiens]
Length = 450
Score = 72.0 bits (175), Expect = 9e-13
Identities = 41/108 (37%), Positives = 61/108 (56%), Gaps = 6/108 (5%)
Query: 309 RNLEENCCVRPLYIDFRQDLGWK-WVHEPKGYYANFCSGPCPY-LRS--ADTTHSTVLGL 364
R C +PL++DF++ LGW W+ P Y A C G C + LRS T H+ + L
Sbjct: 343 RRGRSRCSRKPLHVDFKE-LGWDDWIIAPLDYEAYHCEGLCDFPLRSHLEPTNHAIIQTL 401
Query: 365 YNTLNPEASASPCCVPQDLEPLTILYYVGRTPKV-EQLSNMVVKSCKC 411
N++ P+A+ + CCVP L P++ILY V +Q +MVV++C C
Sbjct: 402 LNSMAPDAAPASCCVPARLSPISILYIDAANNVVYKQYEDMVVEACGC 449
>gi|4503969 growth differentiation factor 5 preproprotein [Homo
sapiens]
Length = 501
Score = 71.6 bits (174), Expect = 1e-12
Identities = 40/108 (37%), Positives = 63/108 (58%), Gaps = 6/108 (5%)
Query: 309 RNLEENCCVRPLYIDFRQDLGWK-WVHEPKGYYANFCSGPCPY-LRS--ADTTHSTVLGL 364
+NL+ C + L+++F+ D+GW W+ P Y A C G C + LRS T H+ + L
Sbjct: 394 KNLKARCSRKALHVNFK-DMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTL 452
Query: 365 YNTLNPEASASPCCVPQDLEPLTILYYVGRTPKV-EQLSNMVVKSCKC 411
N+++PE++ CCVP L P++IL+ V +Q +MVV+SC C
Sbjct: 453 MNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGC 500
>gi|154813204 inhibin beta B subunit preproprotein [Homo sapiens]
Length = 407
Score = 71.6 bits (174), Expect = 1e-12
Identities = 40/107 (37%), Positives = 61/107 (57%), Gaps = 11/107 (10%)
Query: 315 CCVRPLYIDFRQDLGWK-WVHEPKGYYANFCSGPCP-YLR----SADTTHSTVLGLYNT- 367
CC + +IDFR +GW W+ P GYY N+C G CP YL SA + H+ V+ Y
Sbjct: 303 CCRQQFFIDFRL-IGWNDWIIAPTGYYGNYCEGSCPAYLAGVPGSASSFHTAVVNQYRMR 361
Query: 368 -LNPEASASPCCVPQDLEPLTILYYVGRTPKVEQ-LSNMVVKSCKCS 412
LNP + + CC+P L +++LY+ V++ + NM+V+ C C+
Sbjct: 362 GLNP-GTVNSCCIPTKLSTMSMLYFDDEYNIVKRDVPNMIVEECGCA 407
>gi|10190670 growth differentiation factor 3 precursor [Homo
sapiens]
Length = 364
Score = 70.9 bits (172), Expect = 2e-12
Identities = 90/386 (23%), Positives = 150/386 (38%), Gaps = 74/386 (19%)
Query: 48 LSKLRLTSPPEPTVMTHVPYQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHK 107
L L L P P VPY +L+++ +RE T + Y KE+
Sbjct: 30 LQFLGLDKAPSPQKFQPVPY-----------ILKKIFQDREAAATTGVSRDLCYVKELGV 78
Query: 108 FDMIQGLAEHNELAVCPKGITS------KVFRFNVSSVEKNRTNLFRAEFRVLRVPNPSS 161
+ + PK I+ K+ FN+S++ K R L A+ + PN
Sbjct: 79 RGNVLRFLPDQGFFLYPKKISQASSCLQKLLYFNLSAI-KEREQLTLAQLGLDLGPNSYY 137
Query: 162 KRN-EQRIELFQILRPDEHIAKQRYIGGKNLPTRG------TAEW----LSFDVTDTVRE 210
E + LF + P ++ G+ P G + W + F++ D ++
Sbjct: 138 NLGPELELALFLVQEP--------HVWGQTTPKPGKMFVLRSVPWPQGAVHFNLLDVAKD 189
Query: 211 WLLRRESNLGLEISIHCPCHTFQPNGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLKKQ 270
W N GL + I V E + GV+ + + RL+
Sbjct: 190 WNDNPRKNFGLFLEIL------------------VKEDRDSGVNFQPED---TCARLRCS 228
Query: 271 KDHHNPHLILMMIPPHRLDNPGQGGQRKKRALDTNYCFRNLEENCCVRPLYIDFRQDLGW 330
H L+++ NP Q +KR + + C L+I+FR DLGW
Sbjct: 229 L-----HASLLVVTL----NPDQCHPSRKRRAAIPVPKLSCKNLCHRHQLFINFR-DLGW 278
Query: 331 -KWVHEPKGYYANFCSGPCPY---LRSADTTHSTVLGLYNTLNPEASASPCCVPQDLEPL 386
KW+ PKG+ AN+C G CP+ + + ++ + L + ++PE + C+P L P+
Sbjct: 279 HKWIIAPKGFMANYCHGECPFSLTISLNSSNYAFMQALMHAVDPEIPQA-VCIPTKLSPI 337
Query: 387 TILYYVGRTPKV-EQLSNMVVKSCKC 411
++LY + +MVV C C
Sbjct: 338 SMLYQDNNDNVILRHYEDMVVDECGC 363
>gi|5031795 inhibin beta C chain preproprotein [Homo sapiens]
Length = 352
Score = 70.1 bits (170), Expect = 3e-12
Identities = 40/107 (37%), Positives = 59/107 (55%), Gaps = 10/107 (9%)
Query: 315 CCVRPLYIDFRQDLGWK-WVHEPKGYYANFCSGPCPYLRS-----ADTTHSTVLGLY--N 366
CC + ++DFR+ +GW W+ +P+GY NFC G CP + A + H+ VL L N
Sbjct: 247 CCRQEFFVDFRE-IGWHDWIIQPEGYAMNFCIGQCPLHIAGMPGIAASFHTAVLNLLKAN 305
Query: 367 TLNPEASASPCCVPQDLEPLTILYYVGRTPKVE-QLSNMVVKSCKCS 412
T CCVP PL++LYY + V+ + +MVV++C CS
Sbjct: 306 TAAGTTGGGSCCVPTARRPLSLLYYDRDSNIVKTDIPDMVVEACGCS 352
>gi|110349792 growth differentiation factor 1 [Homo sapiens]
Length = 372
Score = 67.8 bits (164), Expect = 2e-11
Identities = 38/106 (35%), Positives = 55/106 (51%), Gaps = 10/106 (9%)
Query: 315 CCVRPLYIDFRQDLGW-KWVHEPKGYYANFCSGPC--PYLRSAD-----TTHSTVLGLYN 366
C R LY+ FR+ +GW +WV P+G+ AN+C G C P S H+ + L +
Sbjct: 267 CRARRLYVSFRE-VGWHRWVIAPRGFLANYCQGQCALPVALSGSGGPPALNHAVLRALMH 325
Query: 367 TLNPEASASPCCVPQDLEPLTILYYVGRTPKV-EQLSNMVVKSCKC 411
P A+ PCCVP L P+++L++ V Q +MVV C C
Sbjct: 326 AAAPGAADLPCCVPARLSPISVLFFDNSDNVVLRQYEDMVVDECGC 371
>gi|126507087 bone morphogenetic protein 3 preproprotein [Homo
sapiens]
Length = 472
Score = 60.5 bits (145), Expect = 3e-09
Identities = 35/104 (33%), Positives = 56/104 (53%), Gaps = 7/104 (6%)
Query: 314 NCCVRPLYIDFRQDLGW-KWVHEPKGYYANFCSGPC--PYLRS-ADTTHSTVLGLYNTLN 369
NC R L +DF D+GW +W+ PK + A +CSG C P +S + H+T+ + +
Sbjct: 369 NCARRYLKVDFA-DIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVG 427
Query: 370 -PEASASPCCVPQDLEPLTILYY-VGRTPKVEQLSNMVVKSCKC 411
PCCVP+ + L+IL++ + ++ NM V+SC C
Sbjct: 428 VVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCAC 471
>gi|153792495 growth differentiation factor 15 [Homo sapiens]
Length = 308
Score = 60.1 bits (144), Expect = 4e-09
Identities = 31/118 (26%), Positives = 51/118 (43%), Gaps = 2/118 (1%)
Query: 295 GQRKKRALDTNYCFRNLEENCCVRPLYIDFRQDLGWK-WVHEPKGYYANFCSGPCPYLRS 353
G+R+ RA + ++C CC +DLGW WV P+ C G CP
Sbjct: 191 GRRRARARNGDHCPLG-PGRCCRLHTVRASLEDLGWADWVLSPREVQVTMCIGACPSQFR 249
Query: 354 ADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKSCKC 411
A H+ + + L P+ +PCCVP P+ ++ ++ +++ K C C
Sbjct: 250 AANMHAQIKTSLHRLKPDTVPAPCCVPASYNPMVLIQKTDTGVSLQTYDDLLAKDCHC 307
>gi|239757187 PREDICTED: similar to growth differentiation factor 15
[Homo sapiens]
Length = 270
Score = 60.1 bits (144), Expect = 4e-09
Identities = 31/118 (26%), Positives = 51/118 (43%), Gaps = 2/118 (1%)
Query: 295 GQRKKRALDTNYCFRNLEENCCVRPLYIDFRQDLGWK-WVHEPKGYYANFCSGPCPYLRS 353
G+R+ RA + ++C CC +DLGW WV P+ C G CP
Sbjct: 153 GRRRARARNGDHCPLG-PGRCCRLHTVRASLEDLGWADWVLSPREVQVTMCIGACPSQFR 211
Query: 354 ADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKSCKC 411
A H+ + + L P+ +PCCVP P+ ++ ++ +++ K C C
Sbjct: 212 AANMHAQIKTSLHRLKPDTVPAPCCVPASYNPMVLIQKTDTGVSLQTYDDLLAKDCHC 269
>gi|222352098 nodal precursor [Homo sapiens]
Length = 347
Score = 52.8 bits (125), Expect = 6e-07
Identities = 29/94 (30%), Positives = 43/94 (45%), Gaps = 5/94 (5%)
Query: 322 IDFRQDLGW-KWVHEPKGYYANFCSGPCPYLRSAD---TTHSTVLGLYNTLNPEASASPC 377
+DF +GW W+ PK Y A C G CP + T H+ + L P S C
Sbjct: 254 VDFNL-IGWGSWIIYPKQYNAYRCEGECPNPVGEEFHPTNHAYIQSLLKRYQPHRVPSTC 312
Query: 378 CVPQDLEPLTILYYVGRTPKVEQLSNMVVKSCKC 411
C P +PL++LY ++ +M+V+ C C
Sbjct: 313 CAPVKTKPLSMLYVDNGRVLLDHHKDMIVEECGC 346
>gi|4885097 bone morphogenetic protein 15 precursor [Homo sapiens]
Length = 392
Score = 52.8 bits (125), Expect = 6e-07
Identities = 32/102 (31%), Positives = 47/102 (46%), Gaps = 6/102 (5%)
Query: 315 CCVRPLYIDFRQDLGWK-WVHEPKGYYANFCSGPC-PYLRSA--DTTHSTVLGLYNTLNP 370
C + P I FRQ LGW W+ P Y N+C G C LR H+ + L N L
Sbjct: 291 CSLHPFQISFRQ-LGWDHWIIAPPFYTPNYCKGTCLRVLRDGLNSPNHAIIQNLINQLVD 349
Query: 371 EASASPCCVPQDLEPLTILYY-VGRTPKVEQLSNMVVKSCKC 411
++ P CVP P+++L + ++ M+ +SC C
Sbjct: 350 QSVPRPSCVPYKYVPISVLMIEANGSILYKEYEGMIAESCTC 391
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.421
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,821,970
Number of Sequences: 37866
Number of extensions: 785447
Number of successful extensions: 1817
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 32
Number of HSP's successfully gapped in prelim test: 18
Number of HSP's that attempted gapping in prelim test: 1709
Number of HSP's gapped (non-prelim): 67
length of query: 412
length of database: 18,247,518
effective HSP length: 105
effective length of query: 307
effective length of database: 14,271,588
effective search space: 4381377516
effective search space used: 4381377516
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.