BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|4507465 transforming growth factor, beta 3 [Homo sapiens] (412 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|4507465 transforming growth factor, beta 3 [Homo sapiens] 857 0.0 gi|4507463 transforming growth factor, beta 2 isoform 2 [Homo sa... 461 e-130 gi|208022653 transforming growth factor, beta 2 isoform 1 [Homo ... 451 e-127 gi|63025222 transforming growth factor, beta 1 [Homo sapiens] 318 7e-87 gi|4885259 myostatin [Homo sapiens] 117 1e-26 gi|4504699 inhibin beta A precursor [Homo sapiens] 106 3e-23 gi|4502427 bone morphogenetic protein 7 precursor [Homo sapiens] 102 8e-22 gi|4502425 bone morphogenetic protein 6 preproprotein [Homo sapi... 102 8e-22 gi|5031613 growth differentiation factor 11 precursor [Homo sapi... 99 7e-21 gi|157276597 bone morphogenetic protein 4 preproprotein [Homo sa... 97 2e-20 gi|157276595 bone morphogenetic protein 4 preproprotein [Homo sa... 97 2e-20 gi|157276593 bone morphogenetic protein 4 preproprotein [Homo sa... 97 2e-20 gi|4557369 bone morphogenetic protein 2 preproprotein [Homo sapi... 94 3e-19 gi|10835091 bone morphogenetic protein 5 preproprotein [Homo sap... 85 1e-16 gi|13899338 activin beta E [Homo sapiens] 84 2e-16 gi|29571106 bone morphogenetic protein 8B preproprotein [Homo sa... 83 4e-16 gi|145611428 bone morphogenetic protein 8A [Homo sapiens] 83 4e-16 gi|7656928 bone morphogenetic protein 10 preproprotein [Homo sap... 82 1e-15 gi|48475062 growth differentiation factor 6 precursor [Homo sapi... 74 2e-13 gi|61835232 growth differentiation factor 7 preproprotein [Homo ... 72 9e-13 gi|4503969 growth differentiation factor 5 preproprotein [Homo s... 72 1e-12 gi|154813204 inhibin beta B subunit preproprotein [Homo sapiens] 72 1e-12 gi|10190670 growth differentiation factor 3 precursor [Homo sapi... 71 2e-12 gi|5031795 inhibin beta C chain preproprotein [Homo sapiens] 70 3e-12 gi|110349792 growth differentiation factor 1 [Homo sapiens] 68 2e-11 gi|126507087 bone morphogenetic protein 3 preproprotein [Homo sa... 60 3e-09 gi|153792495 growth differentiation factor 15 [Homo sapiens] 60 4e-09 gi|239757187 PREDICTED: similar to growth differentiation factor... 60 4e-09 gi|222352098 nodal precursor [Homo sapiens] 53 6e-07 gi|4885097 bone morphogenetic protein 15 precursor [Homo sapiens] 53 6e-07 >gi|4507465 transforming growth factor, beta 3 [Homo sapiens] Length = 412 Score = 857 bits (2214), Expect = 0.0 Identities = 412/412 (100%), Positives = 412/412 (100%) Query: 1 MKMHLQRALVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLTSPPEPT 60 MKMHLQRALVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLTSPPEPT Sbjct: 1 MKMHLQRALVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLTSPPEPT 60 Query: 61 VMTHVPYQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHKFDMIQGLAEHNEL 120 VMTHVPYQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHKFDMIQGLAEHNEL Sbjct: 61 VMTHVPYQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHKFDMIQGLAEHNEL 120 Query: 121 AVCPKGITSKVFRFNVSSVEKNRTNLFRAEFRVLRVPNPSSKRNEQRIELFQILRPDEHI 180 AVCPKGITSKVFRFNVSSVEKNRTNLFRAEFRVLRVPNPSSKRNEQRIELFQILRPDEHI Sbjct: 121 AVCPKGITSKVFRFNVSSVEKNRTNLFRAEFRVLRVPNPSSKRNEQRIELFQILRPDEHI 180 Query: 181 AKQRYIGGKNLPTRGTAEWLSFDVTDTVREWLLRRESNLGLEISIHCPCHTFQPNGDILE 240 AKQRYIGGKNLPTRGTAEWLSFDVTDTVREWLLRRESNLGLEISIHCPCHTFQPNGDILE Sbjct: 181 AKQRYIGGKNLPTRGTAEWLSFDVTDTVREWLLRRESNLGLEISIHCPCHTFQPNGDILE 240 Query: 241 NIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRLDNPGQGGQRKKR 300 NIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRLDNPGQGGQRKKR Sbjct: 241 NIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRLDNPGQGGQRKKR 300 Query: 301 ALDTNYCFRNLEENCCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGPCPYLRSADTTHST 360 ALDTNYCFRNLEENCCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGPCPYLRSADTTHST Sbjct: 301 ALDTNYCFRNLEENCCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGPCPYLRSADTTHST 360 Query: 361 VLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKSCKCS 412 VLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKSCKCS Sbjct: 361 VLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKSCKCS 412 >gi|4507463 transforming growth factor, beta 2 isoform 2 [Homo sapiens] Length = 414 Score = 461 bits (1187), Expect = e-130 Identities = 228/410 (55%), Positives = 294/410 (71%), Gaps = 7/410 (1%) Query: 9 LVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLTSPPEP-TVMTHVPY 67 L +L+ TV+LSLSTC+TLD +KR+EAIRGQILSKL+LTSPPE VP Sbjct: 6 LSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVPP 65 Query: 68 QVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHKFDMIQGLAEHNELAVCPKGI 127 +V+++YNSTR+LL+E R C +E ++ EYYAKE++K DM N + Sbjct: 66 EVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSENAIPPTFYRP 125 Query: 128 TSKVFRFNVSSVEKNRTNLFRAEFRVLRVPNPSSKRNEQRIELFQILRPDEHIAK-QRYI 186 ++ RF+VS++EKN +NL +AEFRV R+ NP ++ EQRIEL+QIL+ + + QRYI Sbjct: 126 YFRIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYQILKSKDLTSPTQRYI 185 Query: 187 GGKNLPTRGTAEWLSFDVTDTVREWLLRRESNLGLEISIHCPCHTFQP-NGDILENIHEV 245 K + TR EWLSFDVTD V EWL ++ NLG +IS+HCPC TF P N I+ N E Sbjct: 186 DSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEE 245 Query: 246 MEIKFKGVDNEDDHGRGDLGRLK---KQKDHHNPHLILMMIPPHRLDNPGQGGQRKKRAL 302 +E +F G+D + GD +K K+ PHL+LM++P +RL++ Q +RKKRAL Sbjct: 246 LEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQ-QTNRRKKRAL 304 Query: 303 DTNYCFRNLEENCCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGPCPYLRSADTTHSTVL 362 D YCFRN+++NCC+RPLYIDF++DLGWKW+HEPKGY ANFC+G CPYL S+DT HS VL Sbjct: 305 DAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVL 364 Query: 363 GLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKSCKCS 412 LYNT+NPEASASPCCV QDLEPLTILYY+G+TPK+EQLSNM+VKSCKCS Sbjct: 365 SLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS 414 >gi|208022653 transforming growth factor, beta 2 isoform 1 [Homo sapiens] Length = 442 Score = 451 bits (1161), Expect = e-127 Identities = 232/441 (52%), Positives = 295/441 (66%), Gaps = 41/441 (9%) Query: 9 LVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLTSPPEP-TVMTHVPY 67 L +L+ TV+LSLSTC+TLD +KR+EAIRGQILSKL+LTSPPE VP Sbjct: 6 LSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVPP 65 Query: 68 QVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHKFDMIQGLAEHNELAVCPKGI 127 +V+++YNSTR+LL+E R C +E ++ EYYAKE++K DM VCP Sbjct: 66 EVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSE---TVCPVVT 122 Query: 128 TS-------------------------------KVFRFNVSSVEKNRTNLFRAEFRVLRV 156 T ++ RF+VS++EKN +NL +AEFRV R+ Sbjct: 123 TPSGSVGSLCSRQSQVLCGYLDAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRL 182 Query: 157 PNPSSKRNEQRIELFQILR-PDEHIAKQRYIGGKNLPTRGTAEWLSFDVTDTVREWLLRR 215 NP ++ EQRIEL+QIL+ D QRYI K + TR EWLSFDVTD V EWL + Sbjct: 183 QNPKARVPEQRIELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHK 242 Query: 216 ESNLGLEISIHCPCHTFQP-NGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLK---KQK 271 + NLG +IS+HCPC TF P N I+ N E +E +F G+D + GD +K K+ Sbjct: 243 DRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKN 302 Query: 272 DHHNPHLILMMIPPHRLDNPGQGGQRKKRALDTNYCFRNLEENCCVRPLYIDFRQDLGWK 331 PHL+LM++P +RL++ Q +RKKRALD YCFRN+++NCC+RPLYIDF++DLGWK Sbjct: 303 SGKTPHLLLMLLPSYRLESQ-QTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWK 361 Query: 332 WVHEPKGYYANFCSGPCPYLRSADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYY 391 W+HEPKGY ANFC+G CPYL S+DT HS VL LYNT+NPEASASPCCV QDLEPLTILYY Sbjct: 362 WIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYY 421 Query: 392 VGRTPKVEQLSNMVVKSCKCS 412 +G+TPK+EQLSNM+VKSCKCS Sbjct: 422 IGKTPKIEQLSNMIVKSCKCS 442 >gi|63025222 transforming growth factor, beta 1 [Homo sapiens] Length = 390 Score = 318 bits (814), Expect = 7e-87 Identities = 190/410 (46%), Positives = 244/410 (59%), Gaps = 40/410 (9%) Query: 9 LVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLTSPPEPTVMTH--VP 66 L+ L +L + LSTC T+D +K+KR+EAIRGQILSKLRL SPP + +P Sbjct: 15 LLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLASPPSQGEVPPGPLP 74 Query: 67 YQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHKFDMIQGLAEHNELAVCPKG 126 VLALYNSTR+ + GE E + E++YYAKE+ + M++ HNE+ K Sbjct: 75 EAVLALYNSTRD---RVAGESAE--PEPEPEADYYAKEVTRVLMVE---THNEIYDKFKQ 126 Query: 127 ITSKVFRF-NVSSVEK---NRTNLFRAEFRVLRVPNPSSKRNEQRIELFQILRPDEHIAK 182 T ++ F N S + + L RAE R+LR+ + EQ +EL+Q + Sbjct: 127 STHSIYMFFNTSELREAVPEPVLLSRAELRLLRL----KLKVEQHVELYQKYSNNSW--- 179 Query: 183 QRYIGGKNLPTRGTAEWLSFDVTDTVREWLLRRESNLGLEISIHCPCHTFQPNGDILENI 242 RY+ + L + EWLSFDVT VR+WL R G +S HC C D +N Sbjct: 180 -RYLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSC-------DSRDNT 231 Query: 243 HEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRLDNPGQGGQRKKRAL 302 +V ++ RGDL + + P L+LM P R + R +RAL Sbjct: 232 LQV------DINGFTTGRRGDLATIHGM---NRPFLLLMATPLERAQH--LQSSRHRRAL 280 Query: 303 DTNYCFRNLEENCCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGPCPYLRSADTTHSTVL 362 DTNYCF + E+NCCVR LYIDFR+DLGWKW+HEPKGY+ANFC GPCPY+ S DT +S VL Sbjct: 281 DTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVL 340 Query: 363 GLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKSCKCS 412 LYN NP ASA+PCCVPQ LEPL I+YYVGR PKVEQLSNM+V+SCKCS Sbjct: 341 ALYNQHNPGASAAPCCVPQALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS 390 >gi|4885259 myostatin [Homo sapiens] Length = 375 Score = 117 bits (294), Expect = 1e-26 Identities = 102/381 (26%), Positives = 169/381 (44%), Gaps = 58/381 (15%) Query: 36 KKKRVEAIRGQILSKLRLTSPPEPTVMTHVPYQVLALYNSTRELLEEMHGEREEGCTQEN 95 K R+EAI+ QILSKLRL + P + V Q+L REL+++ +R++ Sbjct: 49 KSSRIEAIKIQILSKLRLETAPN--ISKDVIRQLLPKAPPLRELIDQYDVQRDDSSDGSL 106 Query: 96 TESEYYAKEIHKFDMIQGLAEHNELAVCPKGITSKVFRFNVSSVEKNRTNLFRAEFRVLR 155 + +Y+A + I + ++ + G F S ++ N+ + + Sbjct: 107 EDDDYHATT----ETIITMPTESDFLMQVDGKPKCCFFKFSSKIQYNKVVKAQLWIYLRP 162 Query: 156 VPNPSSKRNEQRIELFQILRPDEHIAKQRYIGGKNLP---TRGTAEWLSFDVTDTVREWL 212 V P++ +++ ++++P + RY G ++L GT W S DV ++ WL Sbjct: 163 VETPTTVF----VQILRLIKPMKD--GTRYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWL 216 Query: 213 LRRESNLGLEISIHCPCHTFQPNGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKD 272 + ESNLG+EI + EN H+ + + F G +D Sbjct: 217 KQPESNLGIEIKA------------LDENGHD-LAVTFPGPG----------------ED 247 Query: 273 HHNPHLILMMIPPHRLDNPGQGGQRKKRALDTNYCFRNLEENCCVRPLYIDFRQDLGWKW 332 NP L + + D P +R +R + + E CC PL +DF + GW W Sbjct: 248 GLNPFLEVKVT-----DTP----KRSRRDFGLDCDEHSTESRCCRYPLTVDF-EAFGWDW 297 Query: 333 VHEPKGYYANFCSGPCPYLRSADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYYV 392 + PK Y AN+CSG C ++ H+ L + NP SA PCC P + P+ +LY+ Sbjct: 298 IIAPKRYKANYCSGECEFVFLQKYPHT---HLVHQANPRGSAGPCCTPTKMSPINMLYFN 354 Query: 393 GRTPKV-EQLSNMVVKSCKCS 412 G+ + ++ MVV C CS Sbjct: 355 GKEQIIYGKIPAMVVDRCGCS 375 >gi|4504699 inhibin beta A precursor [Homo sapiens] Length = 426 Score = 106 bits (265), Expect = 3e-23 Identities = 101/407 (24%), Positives = 180/407 (44%), Gaps = 51/407 (12%) Query: 31 DFGHIKKKRVEAIRGQILSKLRLTSPPEPTVMTHVPYQVLALYNSTRELLEEMHGEREEG 90 D + + + VEA++ IL+ L L P+ T P AL N+ R+L G Sbjct: 46 DVPNSQPEMVEAVKKHILNMLHLKKRPDVTQ----PVPKAALLNAIRKL--------HVG 93 Query: 91 CTQENTESEYYAKEIHKFDMIQGLAEHNELAV-CPKGITSKVFRFNVSSVEKNRTNLFRA 149 EN E + +M + + + +E+ G K F +S + + + RA Sbjct: 94 KVGENGYVEIEDDIGRRAEMNELMEQTSEIITFAESGTARKTLHFEISKEGSDLSVVERA 153 Query: 150 E-FRVLRVPNPSSKRNEQRIELFQILRPDEHIA--------------KQRYIGGKNLPTR 194 E + L+VP + R + I LFQ + + + + + + Sbjct: 154 EVWLFLKVPKANRTRTKVTIRLFQQQKHPQGSLDTGEEAEEVGLKGERSELLLSEKVVDA 213 Query: 195 GTAEWLSFDVTDTVREWLLRRESNLGLEISIHCPCHTFQPNGDILENIHEVMEIKFKGVD 254 + W F V+ +++ L + +S+L + I+ C Q +G L + + + + +G Sbjct: 214 RKSTWHVFPVSSSIQRLLDQGKSSLDVRIA----CEQCQESGASLVLLGKKKKKEEEGEG 269 Query: 255 NEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRLDNPGQGGQRKKRALDTNYCFRNLEEN 314 + G G G ++++ H P L+L D+P + R++R L+ + Sbjct: 270 KKKGGGEGGAGADEEKEQSHRPFLMLQARQSE--DHPHR---RRRRGLECD----GKVNI 320 Query: 315 CCVRPLYIDFRQDLGWK-WVHEPKGYYANFCSGPCP-----YLRSADTTHSTVLGLYNTL 368 CC + ++ F+ D+GW W+ P GY+AN+C G CP S+ + HSTV+ Y Sbjct: 321 CCKKQFFVSFK-DIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMR 379 Query: 369 --NPEASASPCCVPQDLEPLTILYY-VGRTPKVEQLSNMVVKSCKCS 412 +P A+ CCVP L P+++LYY G+ + + NM+V+ C CS Sbjct: 380 GHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS 426 >gi|4502427 bone morphogenetic protein 7 precursor [Homo sapiens] Length = 431 Score = 102 bits (253), Expect = 8e-22 Identities = 105/440 (23%), Positives = 182/440 (41%), Gaps = 70/440 (15%) Query: 12 LALLNFATVSLSLSTCTTLDFGH--IKKKRVEAIRGQILSKLRLTSPPEPTVM---THVP 66 L LL A SL F H ++ + ++ +ILS L L P P + P Sbjct: 21 LFLLRSALADFSLDNEVHSSFIHRRLRSQERREMQREILSILGLPHRPRPHLQGKHNSAP 80 Query: 67 YQVLALYNSTRELLEEMHGEREEGCTQE-------------NTESEYYAKEIHKFDMIQG 113 +L LYN+ +EE G +G + + + ++ + Sbjct: 81 MFMLDLYNAMA--VEEGGGPGGQGFSYPYKAVFSTQGPPLASLQDSHFLTDADMVMSFVN 138 Query: 114 LAEHNELAVCPKGITSKVFRFNVSSVEKNRTNLFRAEFRVLRVPNPSSKRNEQ-RIELFQ 172 L EH++ P+ + FRF++S + + + AEFR+ + NE RI ++Q Sbjct: 139 LVEHDKEFFHPR-YHHREFRFDLSKIPEGEA-VTAAEFRIYKDYIRERFDNETFRISVYQ 196 Query: 173 ILRPDEHIAKQRYIGGKNLPTRGTAE--WLSFDVTDTVREWLLRRESNLGLEISIHC--- 227 +L+ EH+ ++ + + T +E WL FD+T T W++ NLGL++S+ Sbjct: 197 VLQ--EHLGRESDLFLLDSRTLWASEEGWLVFDITATSNHWVVNPRHNLGLQLSVETLDG 254 Query: 228 -----------PCHTFQPNGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNP 276 H Q + + E+ F+ + + R + K N Sbjct: 255 QSINPKLAGLIGRHGPQNKQPFMVAFFKATEVHFRSIRSTGSKQRSQ----NRSKTPKNQ 310 Query: 277 HLILMMIPPHRLDNPGQGGQRKKRALDTNYCFRNLEENCCVRPLYIDFRQDLGWK-WVHE 335 + R+ N + +R + C LY+ FR DLGW+ W+ Sbjct: 311 EAL-------RMANVAENSSSDQR------------QACKKHELYVSFR-DLGWQDWIIA 350 Query: 336 PKGYYANFCSGPCPYLRSA---DTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYYV 392 P+GY A +C G C + ++ T H+ V L + +NPE PCC P L +++LY+ Sbjct: 351 PEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPETVPKPCCAPTQLNAISVLYFD 410 Query: 393 GRTPKV-EQLSNMVVKSCKC 411 + + ++ NMVV++C C Sbjct: 411 DSSNVILKKYRNMVVRACGC 430 >gi|4502425 bone morphogenetic protein 6 preproprotein [Homo sapiens] Length = 513 Score = 102 bits (253), Expect = 8e-22 Identities = 78/296 (26%), Positives = 131/296 (44%), Gaps = 21/296 (7%) Query: 124 PKGITSKVFRFNVSSVEKNRTNLFRAEFRVLRVPNPSSKRNEQ-RIELFQILRPDEHIAK 182 P+ K F+FN+S + + + AEFR+ + S +N+ I ++Q+L+ +H Sbjct: 230 PRQRHHKEFKFNLSQIPEGEV-VTAAEFRIYKDCVMGSFKNQTFLISIYQVLQEHQHRDS 288 Query: 183 QRYIGGKNLPTRGTAEWLSFDVTDTVREWLLRRESNLGLEISIHCPCHTFQPNGDILENI 242 ++ + WL FD+T T W++ + N+GL++S+ + + Sbjct: 289 DLFLLDTRVVWASEEGWLEFDITATSNLWVVTPQHNMGLQLSVVTR-----------DGV 337 Query: 243 H-EVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRLDNPGQGGQRKKRA 301 H G D D + K + H + N Q R Sbjct: 338 HVHPRAAGLVGRDGPYDKQPFMVAFFKVSEVHVRTTRSASSRRRQQSRNRSTQSQDVARV 397 Query: 302 LD-TNYCFRNLEENCCVRPLYIDFRQDLGWK-WVHEPKGYYANFCSGPCPYLRSAD---T 356 ++Y L+ C LY+ F QDLGW+ W+ PKGY AN+C G C + +A T Sbjct: 398 SSASDYNSSELKTACRKHELYVSF-QDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNAT 456 Query: 357 THSTVLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKV-EQLSNMVVKSCKC 411 H+ V L + +NPE PCC P L +++LY+ + + ++ NMVV++C C Sbjct: 457 NHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYFDDNSNVILKKYRNMVVRACGC 512 >gi|5031613 growth differentiation factor 11 precursor [Homo sapiens] Length = 407 Score = 99.0 bits (245), Expect = 7e-21 Identities = 104/399 (26%), Positives = 165/399 (41%), Gaps = 81/399 (20%) Query: 34 HIKKKRVEAIRGQILSKLRLTSPPEPTVMTHVPYQVLALYNSTRELLEEMHGEREEGCTQ 93 H ++ R+E+I+ QILSKLRL P + V Q+L +++L+ +H + + Sbjct: 70 HSRELRLESIKSQILSKLRLKEAPN--ISREVVKQLLPKAPPLQQILD-LHDFQGDALQP 126 Query: 94 EN--TESEYYAKEIHKFDMIQGLAEHNELAVCPKGITSKVFRFNVSSVEKNRTNLFRAEF 151 E+ E EY+A + + +A+ + AV G + F+ S + T + +A+ Sbjct: 127 EDFLEEDEYHATT----ETVISMAQETDPAVQTDG-SPLCCHFHFSP-KVMFTKVLKAQL 180 Query: 152 RV-LR-VPNPSSKRNEQRIELFQILRPDEHIAKQRYIGG----KNLPTRG--------TA 197 V LR VP P++ QILR + GG +++ R + Sbjct: 181 WVYLRPVPRPATV-------YLQILRLKPLTGEGTAGGGGGGRRHIRIRSLKIELHSRSG 233 Query: 198 EWLSFDVTDTVREWLLRRESNLGLEISIHCPCHT---FQPNGDILENIHEVMEIKFKGVD 254 W S D + W + +SN G+EI+ P T G E +H ME++ Sbjct: 234 HWQSIDFKQVLHSWFRQPQSNWGIEINAFDPSGTDLAVTSLGPGAEGLHPFMELRV---- 289 Query: 255 NEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRLDNPGQGGQRKKRALDTNYCFRNLEEN 314 L+N +R +R L + + E Sbjct: 290 ---------------------------------LENT----KRSRRNLGLDCDEHSSESR 312 Query: 315 CCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGPCPYLRSADTTHSTVLGLYNTLNPEASA 374 CC PL +DF + GW W+ PK Y AN+CSG C Y+ H+ L NP SA Sbjct: 313 CCRYPLTVDF-EAFGWDWIIAPKRYKANYCSGQCEYMFMQKYPHT---HLVQQANPRGSA 368 Query: 375 SPCCVPQDLEPLTILYYVGRTPKV-EQLSNMVVKSCKCS 412 PCC P + P+ +LY+ + + ++ MVV C CS Sbjct: 369 GPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGCS 407 >gi|157276597 bone morphogenetic protein 4 preproprotein [Homo sapiens] Length = 408 Score = 97.4 bits (241), Expect = 2e-20 Identities = 98/384 (25%), Positives = 161/384 (41%), Gaps = 56/384 (14%) Query: 47 ILSKLRLTSPPEPTVMTHVPYQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIH 106 +L L P+P+ +P + R+L GE EE +T EY + Sbjct: 61 LLQMFGLRRRPQPSKSAVIP-------DYMRDLYRLQSGEEEEEQIH-STGLEYPERPAS 112 Query: 107 KFDMIQGLAEHNELAVCPKGITSKVFRF--NVSSVEKNRTNLFRAEFRVLRVP---NPSS 161 + + ++ L P + FRF N+SS+ +N + AE R+ R P Sbjct: 113 RANTVRSFHHEEHLENIPGTSENSAFRFLFNLSSIPENEV-ISSAELRLFREQVDQGPDW 171 Query: 162 KRNEQRIELFQILRPDEHIAKQRYIGGKNLPTR----GTAEWLSFDVTDTVREWLLRRES 217 +R RI ++++++P + I + L TR W +FDV+ V W ++ Sbjct: 172 ERGFHRINIYEVMKPPAEVVPGHLIT-RLLDTRLVHHNVTRWETFDVSPAVLRWTREKQP 230 Query: 218 NLGLEISIHCPCHTFQPNGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPH 277 N GL I + H Q H+ ++ + G G+ +L+ Sbjct: 231 NYGLAIEV---THLHQTR------THQGQHVR---ISRSLPQGSGNWAQLRP-------- 270 Query: 278 LILMMIPPHRLDNPGQGGQRKKRALDT----NYCFRNLEENCCVRPLYIDFRQDLGWK-W 332 L++ H D G R++RA + + R +NC LY+DF D+GW W Sbjct: 271 --LLVTFGH--DGRGHALTRRRRAKRSPKHHSQRARKKNKNCRRHSLYVDF-SDVGWNDW 325 Query: 333 VHEPKGYYANFCSGPCPYLRS---ADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTIL 389 + P GY A +C G CP+ + T H+ V L N++N + CCVP +L +++L Sbjct: 326 IVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVN-SSIPKACCVPTELSAISML 384 Query: 390 YYVGRTPKV--EQLSNMVVKSCKC 411 Y+ KV + MVV+ C C Sbjct: 385 -YLDEYDKVVLKNYQEMVVEGCGC 407 >gi|157276595 bone morphogenetic protein 4 preproprotein [Homo sapiens] Length = 408 Score = 97.4 bits (241), Expect = 2e-20 Identities = 98/384 (25%), Positives = 161/384 (41%), Gaps = 56/384 (14%) Query: 47 ILSKLRLTSPPEPTVMTHVPYQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIH 106 +L L P+P+ +P + R+L GE EE +T EY + Sbjct: 61 LLQMFGLRRRPQPSKSAVIP-------DYMRDLYRLQSGEEEEEQIH-STGLEYPERPAS 112 Query: 107 KFDMIQGLAEHNELAVCPKGITSKVFRF--NVSSVEKNRTNLFRAEFRVLRVP---NPSS 161 + + ++ L P + FRF N+SS+ +N + AE R+ R P Sbjct: 113 RANTVRSFHHEEHLENIPGTSENSAFRFLFNLSSIPENEV-ISSAELRLFREQVDQGPDW 171 Query: 162 KRNEQRIELFQILRPDEHIAKQRYIGGKNLPTR----GTAEWLSFDVTDTVREWLLRRES 217 +R RI ++++++P + I + L TR W +FDV+ V W ++ Sbjct: 172 ERGFHRINIYEVMKPPAEVVPGHLIT-RLLDTRLVHHNVTRWETFDVSPAVLRWTREKQP 230 Query: 218 NLGLEISIHCPCHTFQPNGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPH 277 N GL I + H Q H+ ++ + G G+ +L+ Sbjct: 231 NYGLAIEV---THLHQTR------THQGQHVR---ISRSLPQGSGNWAQLRP-------- 270 Query: 278 LILMMIPPHRLDNPGQGGQRKKRALDT----NYCFRNLEENCCVRPLYIDFRQDLGWK-W 332 L++ H D G R++RA + + R +NC LY+DF D+GW W Sbjct: 271 --LLVTFGH--DGRGHALTRRRRAKRSPKHHSQRARKKNKNCRRHSLYVDF-SDVGWNDW 325 Query: 333 VHEPKGYYANFCSGPCPYLRS---ADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTIL 389 + P GY A +C G CP+ + T H+ V L N++N + CCVP +L +++L Sbjct: 326 IVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVN-SSIPKACCVPTELSAISML 384 Query: 390 YYVGRTPKV--EQLSNMVVKSCKC 411 Y+ KV + MVV+ C C Sbjct: 385 -YLDEYDKVVLKNYQEMVVEGCGC 407 >gi|157276593 bone morphogenetic protein 4 preproprotein [Homo sapiens] Length = 408 Score = 97.4 bits (241), Expect = 2e-20 Identities = 98/384 (25%), Positives = 161/384 (41%), Gaps = 56/384 (14%) Query: 47 ILSKLRLTSPPEPTVMTHVPYQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIH 106 +L L P+P+ +P + R+L GE EE +T EY + Sbjct: 61 LLQMFGLRRRPQPSKSAVIP-------DYMRDLYRLQSGEEEEEQIH-STGLEYPERPAS 112 Query: 107 KFDMIQGLAEHNELAVCPKGITSKVFRF--NVSSVEKNRTNLFRAEFRVLRVP---NPSS 161 + + ++ L P + FRF N+SS+ +N + AE R+ R P Sbjct: 113 RANTVRSFHHEEHLENIPGTSENSAFRFLFNLSSIPENEV-ISSAELRLFREQVDQGPDW 171 Query: 162 KRNEQRIELFQILRPDEHIAKQRYIGGKNLPTR----GTAEWLSFDVTDTVREWLLRRES 217 +R RI ++++++P + I + L TR W +FDV+ V W ++ Sbjct: 172 ERGFHRINIYEVMKPPAEVVPGHLIT-RLLDTRLVHHNVTRWETFDVSPAVLRWTREKQP 230 Query: 218 NLGLEISIHCPCHTFQPNGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPH 277 N GL I + H Q H+ ++ + G G+ +L+ Sbjct: 231 NYGLAIEV---THLHQTR------THQGQHVR---ISRSLPQGSGNWAQLRP-------- 270 Query: 278 LILMMIPPHRLDNPGQGGQRKKRALDT----NYCFRNLEENCCVRPLYIDFRQDLGWK-W 332 L++ H D G R++RA + + R +NC LY+DF D+GW W Sbjct: 271 --LLVTFGH--DGRGHALTRRRRAKRSPKHHSQRARKKNKNCRRHSLYVDF-SDVGWNDW 325 Query: 333 VHEPKGYYANFCSGPCPYLRS---ADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTIL 389 + P GY A +C G CP+ + T H+ V L N++N + CCVP +L +++L Sbjct: 326 IVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVN-SSIPKACCVPTELSAISML 384 Query: 390 YYVGRTPKV--EQLSNMVVKSCKC 411 Y+ KV + MVV+ C C Sbjct: 385 -YLDEYDKVVLKNYQEMVVEGCGC 407 >gi|4557369 bone morphogenetic protein 2 preproprotein [Homo sapiens] Length = 396 Score = 93.6 bits (231), Expect = 3e-19 Identities = 96/382 (25%), Positives = 164/382 (42%), Gaps = 58/382 (15%) Query: 46 QILSKLRLTSPPEPTVMTHVPYQVLALY--NSTRELLEEMHGEREEGCTQENTESEYYAK 103 ++LS L P P+ VP +L LY +S + E ++ NT + Sbjct: 56 RLLSMFGLKQRPTPSRDAVVPPYMLDLYRRHSGQPGSPAPDHRLERAASRANT-----VR 110 Query: 104 EIHKFDMIQGLAEHNELAVCPKGITSKVFRFNVSSVEKNRTNLFRAEFRVLRVPNPSSKR 163 H + ++ L E + G T++ F FN+SS+ + AE +V R + Sbjct: 111 SFHHEESLEELPETS-------GKTTRRFFFNLSSIPTEEF-ITSAELQVFREQMQDALG 162 Query: 164 NEQ----RIELFQILRPDEHIAKQRYIGGKNLPTR----GTAEWLSFDVTDTVREWLLRR 215 N RI +++I++P A ++ + L TR + W SFDVT V W + Sbjct: 163 NNSSFHHRINIYEIIKPAT--ANSKFPVTRLLDTRLVNQNASRWESFDVTPAVMRWTAQG 220 Query: 216 ESNLGLEISIHCPCHTFQPNGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHN 275 +N G + + H + G ++ + ++D+H + L H Sbjct: 221 HANHGFVVEV---AHLEEKQGVSKRHVRISRSL------HQDEHSWSQIRPLLVTFGHDG 271 Query: 276 PHLILMMIPPHRLDNPGQGGQRKKRALDTNYCFRNLEENCCVRPLYIDFRQDLGWK-WVH 334 P H+ + +++KR L+ +C PLY+DF D+GW W+ Sbjct: 272 KGH-----PLHKREKRQAKHKQRKR----------LKSSCKRHPLYVDF-SDVGWNDWIV 315 Query: 335 EPKGYYANFCSGPCPYLRS---ADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYY 391 P GY+A +C G CP+ + T H+ V L N++N + + CCVP +L +++L Y Sbjct: 316 APPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNSKIPKA-CCVPTELSAISML-Y 373 Query: 392 VGRTPKV--EQLSNMVVKSCKC 411 + KV + +MVV+ C C Sbjct: 374 LDENEKVVLKNYQDMVVEGCGC 395 >gi|10835091 bone morphogenetic protein 5 preproprotein [Homo sapiens] Length = 454 Score = 85.1 bits (209), Expect = 1e-16 Identities = 75/303 (24%), Positives = 132/303 (43%), Gaps = 48/303 (15%) Query: 130 KVFRFNVSSVEKNRTNLFRAEFRVLRVPNPSSKRNEQ-RIELFQILRPDEHIAKQRYIGG 188 K FRF+++ + + AEFR+ + + + NE +I ++QI++ + ++ Sbjct: 178 KEFRFDLTQIPHGEA-VTAAEFRIYKDRSNNRFENETIKISIYQIIKEYTNRDADLFLLD 236 Query: 189 KNLPTRGTAEWLSFDVTDTVREWLLRRESNLGLEISIHCPCHTFQPNGDILENIHEVMEI 248 WL FD+T T W++ ++NLGL++ GD + + Sbjct: 237 TRKAQALDVGWLVFDITVTSNHWVINPQNNLGLQLCAE--------TGD-----GRSINV 283 Query: 249 KFKGVDNEDDHGRGDLGRLKKQKDHHNPHLIL------MMIPPHRLDNPGQGGQRKKRAL 302 K G+ G G KQ P ++ +++ R N + R K + Sbjct: 284 KSAGLV-------GRQGPQSKQ-----PFMVAFFKASEVLLRSVRAANKRKNQNRNKSSS 331 Query: 303 DTN---------YCFRNLEENCCVRPLYIDFRQDLGWK-WVHEPKGYYANFCSGPCPYLR 352 + Y ++ C LY+ FR DLGW+ W+ P+GY A +C G C + Sbjct: 332 HQDSSRMSSVGDYNTSEQKQACKKHELYVSFR-DLGWQDWIIAPEGYAAFYCDGECSFPL 390 Query: 353 SAD---TTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKV-EQLSNMVVKS 408 +A T H+ V L + + P+ PCC P L +++LY+ + + ++ NMVV+S Sbjct: 391 NAHMNATNHAIVQTLVHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRS 450 Query: 409 CKC 411 C C Sbjct: 451 CGC 453 >gi|13899338 activin beta E [Homo sapiens] Length = 350 Score = 84.3 bits (207), Expect = 2e-16 Identities = 58/159 (36%), Positives = 82/159 (51%), Gaps = 19/159 (11%) Query: 262 GDLGRLKKQKDHHNPHLILMMIPPHRLDNPGQGGQRKKRALDTNYCFRNLEENCCVRPLY 321 G RL H P L L + R + PG G R++ T C CC R Y Sbjct: 203 GQPRRLLDTAGHQQPFLELKI----RANEPGAGRARRR----TPTC-EPATPLCCRRDHY 253 Query: 322 IDFRQDLGWK-WVHEPKGYYANFCSGPC-PYLRS----ADTTHSTVLGLYNTLNPEASAS 375 +DF Q+LGW+ W+ +P+GY N+CSG C P+L A + HS V L NP +++ Sbjct: 254 VDF-QELGWRDWILQPEGYQLNYCSGQCPPHLAGSPGIAASFHSAVFSLLKANNPWPAST 312 Query: 376 PCCVPQDLEPLTILY--YVGRTPKVEQLSNMVVKSCKCS 412 CCVP PL++LY + G K + + +MVV++C CS Sbjct: 313 SCCVPTARRPLSLLYLDHNGNVVKTD-VPDMVVEACGCS 350 >gi|29571106 bone morphogenetic protein 8B preproprotein [Homo sapiens] Length = 402 Score = 83.2 bits (204), Expect = 4e-16 Identities = 72/294 (24%), Positives = 118/294 (40%), Gaps = 30/294 (10%) Query: 130 KVFRFNVSSVEKNRTNLFRAEFRVLRVPNPSSKRNEQRIELFQILRPDEHIAKQRYIGGK 189 K FRF+++ + + AEFR+ +VP+ + +FQ+++ + + Sbjct: 126 KEFRFDLTQIPAGEA-VTAAEFRIYKVPSIHLLNRTLHVSMFQVVQEQSNRESDLFFLDL 184 Query: 190 NLPTRGTAEWLSFDVTDTVREWLLRRESNLGLEISIHCPC-HTFQPN-----GDILENIH 243 G WL DVT WLL+R +LGL + + H+ P G Sbjct: 185 QTLRAGDEGWLVLDVTAASDCWLLKRHKDLGLRLYVETEDGHSVDPGLAGLLGQRAPRSQ 244 Query: 244 EVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRLDNP-GQGGQRKKRAL 302 + + F + L++++ + L P D+ G G++ Sbjct: 245 QPFVVTFFRASPSPIRTPRAVRPLRRRQPKKSNELPQANRLPGIFDDVHGSHGRQV---- 300 Query: 303 DTNYCFRNLEENCCVRPLYIDFRQDLGW-KWVHEPKGYYANFCSGPCPYLRSA---DTTH 358 C LY+ F QDLGW WV P+GY A +C G C + + T H Sbjct: 301 ------------CRRHELYVSF-QDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNH 347 Query: 359 STVLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKV-EQLSNMVVKSCKC 411 + + L + + P+A CC P L ++LYY + + NMVVK+C C Sbjct: 348 AILQSLVHLMMPDAVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGC 401 >gi|145611428 bone morphogenetic protein 8A [Homo sapiens] Length = 402 Score = 83.2 bits (204), Expect = 4e-16 Identities = 72/294 (24%), Positives = 117/294 (39%), Gaps = 30/294 (10%) Query: 130 KVFRFNVSSVEKNRTNLFRAEFRVLRVPNPSSKRNEQRIELFQILRPDEHIAKQRYIGGK 189 K FRF+++ + + AEFR+ +VP+ + +FQ+++ + + Sbjct: 126 KEFRFDLTQIPAGEA-VTAAEFRIYKVPSIHLLNRTLHVSMFQVVQEQSNRESDLFFLDL 184 Query: 190 NLPTRGTAEWLSFDVTDTVREWLLRRESNLGLEISIHCPC-HTFQPN-----GDILENIH 243 G WL DVT WLL+R +LGL + + H+ P G Sbjct: 185 QTLRAGDEGWLVLDVTAASDCWLLKRHKDLGLRLYVETEDGHSVDPGLAGLLGQRAPRSQ 244 Query: 244 EVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRLDNP-GQGGQRKKRAL 302 + + F + L++++ + L P D+ G G++ Sbjct: 245 QPFVVTFFRASPSPIRTPRAVRPLRRRQPKKSNELPQANRLPGIFDDVRGSHGRQV---- 300 Query: 303 DTNYCFRNLEENCCVRPLYIDFRQDLGW-KWVHEPKGYYANFCSGPCPYLRSA---DTTH 358 C LY+ F QDLGW WV P+GY A +C G C + + T H Sbjct: 301 ------------CRRHELYVSF-QDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNH 347 Query: 359 STVLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKV-EQLSNMVVKSCKC 411 + + L + + P A CC P L ++LYY + + NMVVK+C C Sbjct: 348 AILQSLVHLMKPNAVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGC 401 >gi|7656928 bone morphogenetic protein 10 preproprotein [Homo sapiens] Length = 424 Score = 81.6 bits (200), Expect = 1e-15 Identities = 75/277 (27%), Positives = 116/277 (41%), Gaps = 45/277 (16%) Query: 165 EQRIELFQILRPDEHIAKQR----YIGGKNLPTRGTAEWLSFDVTDTVREWLLRRESNLG 220 +++I +F++L +R + G+ T +EW +FDVTD +R W S Sbjct: 162 DRKITIFEVLESKGDNEGERNMLVLVSGEIYGTN--SEWETFDVTDAIRRWQKSGSSTHQ 219 Query: 221 LEISIHCPCHTFQPNGD-------ILENIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDH 273 LE+ I + +N H + I F + D K++K+ Sbjct: 220 LEVHIESKHDEAEDASSGRLEIDTSAQNKHNPLLIVFSDDQSSD----------KERKEE 269 Query: 274 HNPHLILMMIPPHRLDNPGQG------GQRKKRALDTNYCF-------RNLEENCCVR-P 319 N + +P LDN G G+ + +N + RN + N C R P Sbjct: 270 LNEMISHEQLP--ELDNLGLDSFSSGPGEEALLQMRSNIIYDSTARIRRNAKGNYCKRTP 327 Query: 320 LYIDFRQDLGW-KWVHEPKGYYANFCSGPCPYLRS---ADTTHSTVLGLYNTLNPEASAS 375 LYIDF++ +GW W+ P GY A C G C Y + T H+ + L + N + ++ Sbjct: 328 LYIDFKE-IGWDSWIIAPPGYEAYECRGVCNYPLAEHLTPTKHAIIQALVHLKNSQKASK 386 Query: 376 PCCVPQDLEPLTILYY-VGRTPKVEQLSNMVVKSCKC 411 CCVP LEP++ILY G + M V C C Sbjct: 387 ACCVPTKLEPISILYLDKGVVTYKFKYEGMAVSECGC 423 >gi|48475062 growth differentiation factor 6 precursor [Homo sapiens] Length = 455 Score = 74.3 bits (181), Expect = 2e-13 Identities = 44/129 (34%), Positives = 73/129 (56%), Gaps = 9/129 (6%) Query: 291 PGQGGQRKKRALDTNYCFRNLEEN---CCVRPLYIDFRQDLGWK-WVHEPKGYYANFCSG 346 P G +R++ A + + R+ +++ C +PL+++F++ LGW W+ P Y A C G Sbjct: 327 PSPGRRRRRTAFASRHGKRHGKKSRLRCSKKPLHVNFKE-LGWDDWIIAPLEYEAYHCEG 385 Query: 347 PCPY-LRS--ADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYY-VGRTPKVEQLS 402 C + LRS T H+ + L N+++P ++ CCVP L P++ILY G +Q Sbjct: 386 VCDFPLRSHLEPTNHAIIQTLMNSMDPGSTPPSCCVPTKLTPISILYIDAGNNVVYKQYE 445 Query: 403 NMVVKSCKC 411 +MVV+SC C Sbjct: 446 DMVVESCGC 454 >gi|61835232 growth differentiation factor 7 preproprotein [Homo sapiens] Length = 450 Score = 72.0 bits (175), Expect = 9e-13 Identities = 41/108 (37%), Positives = 61/108 (56%), Gaps = 6/108 (5%) Query: 309 RNLEENCCVRPLYIDFRQDLGWK-WVHEPKGYYANFCSGPCPY-LRS--ADTTHSTVLGL 364 R C +PL++DF++ LGW W+ P Y A C G C + LRS T H+ + L Sbjct: 343 RRGRSRCSRKPLHVDFKE-LGWDDWIIAPLDYEAYHCEGLCDFPLRSHLEPTNHAIIQTL 401 Query: 365 YNTLNPEASASPCCVPQDLEPLTILYYVGRTPKV-EQLSNMVVKSCKC 411 N++ P+A+ + CCVP L P++ILY V +Q +MVV++C C Sbjct: 402 LNSMAPDAAPASCCVPARLSPISILYIDAANNVVYKQYEDMVVEACGC 449 >gi|4503969 growth differentiation factor 5 preproprotein [Homo sapiens] Length = 501 Score = 71.6 bits (174), Expect = 1e-12 Identities = 40/108 (37%), Positives = 63/108 (58%), Gaps = 6/108 (5%) Query: 309 RNLEENCCVRPLYIDFRQDLGWK-WVHEPKGYYANFCSGPCPY-LRS--ADTTHSTVLGL 364 +NL+ C + L+++F+ D+GW W+ P Y A C G C + LRS T H+ + L Sbjct: 394 KNLKARCSRKALHVNFK-DMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTL 452 Query: 365 YNTLNPEASASPCCVPQDLEPLTILYYVGRTPKV-EQLSNMVVKSCKC 411 N+++PE++ CCVP L P++IL+ V +Q +MVV+SC C Sbjct: 453 MNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGC 500 >gi|154813204 inhibin beta B subunit preproprotein [Homo sapiens] Length = 407 Score = 71.6 bits (174), Expect = 1e-12 Identities = 40/107 (37%), Positives = 61/107 (57%), Gaps = 11/107 (10%) Query: 315 CCVRPLYIDFRQDLGWK-WVHEPKGYYANFCSGPCP-YLR----SADTTHSTVLGLYNT- 367 CC + +IDFR +GW W+ P GYY N+C G CP YL SA + H+ V+ Y Sbjct: 303 CCRQQFFIDFRL-IGWNDWIIAPTGYYGNYCEGSCPAYLAGVPGSASSFHTAVVNQYRMR 361 Query: 368 -LNPEASASPCCVPQDLEPLTILYYVGRTPKVEQ-LSNMVVKSCKCS 412 LNP + + CC+P L +++LY+ V++ + NM+V+ C C+ Sbjct: 362 GLNP-GTVNSCCIPTKLSTMSMLYFDDEYNIVKRDVPNMIVEECGCA 407 >gi|10190670 growth differentiation factor 3 precursor [Homo sapiens] Length = 364 Score = 70.9 bits (172), Expect = 2e-12 Identities = 90/386 (23%), Positives = 150/386 (38%), Gaps = 74/386 (19%) Query: 48 LSKLRLTSPPEPTVMTHVPYQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHK 107 L L L P P VPY +L+++ +RE T + Y KE+ Sbjct: 30 LQFLGLDKAPSPQKFQPVPY-----------ILKKIFQDREAAATTGVSRDLCYVKELGV 78 Query: 108 FDMIQGLAEHNELAVCPKGITS------KVFRFNVSSVEKNRTNLFRAEFRVLRVPNPSS 161 + + PK I+ K+ FN+S++ K R L A+ + PN Sbjct: 79 RGNVLRFLPDQGFFLYPKKISQASSCLQKLLYFNLSAI-KEREQLTLAQLGLDLGPNSYY 137 Query: 162 KRN-EQRIELFQILRPDEHIAKQRYIGGKNLPTRG------TAEW----LSFDVTDTVRE 210 E + LF + P ++ G+ P G + W + F++ D ++ Sbjct: 138 NLGPELELALFLVQEP--------HVWGQTTPKPGKMFVLRSVPWPQGAVHFNLLDVAKD 189 Query: 211 WLLRRESNLGLEISIHCPCHTFQPNGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLKKQ 270 W N GL + I V E + GV+ + + RL+ Sbjct: 190 WNDNPRKNFGLFLEIL------------------VKEDRDSGVNFQPED---TCARLRCS 228 Query: 271 KDHHNPHLILMMIPPHRLDNPGQGGQRKKRALDTNYCFRNLEENCCVRPLYIDFRQDLGW 330 H L+++ NP Q +KR + + C L+I+FR DLGW Sbjct: 229 L-----HASLLVVTL----NPDQCHPSRKRRAAIPVPKLSCKNLCHRHQLFINFR-DLGW 278 Query: 331 -KWVHEPKGYYANFCSGPCPY---LRSADTTHSTVLGLYNTLNPEASASPCCVPQDLEPL 386 KW+ PKG+ AN+C G CP+ + + ++ + L + ++PE + C+P L P+ Sbjct: 279 HKWIIAPKGFMANYCHGECPFSLTISLNSSNYAFMQALMHAVDPEIPQA-VCIPTKLSPI 337 Query: 387 TILYYVGRTPKV-EQLSNMVVKSCKC 411 ++LY + +MVV C C Sbjct: 338 SMLYQDNNDNVILRHYEDMVVDECGC 363 >gi|5031795 inhibin beta C chain preproprotein [Homo sapiens] Length = 352 Score = 70.1 bits (170), Expect = 3e-12 Identities = 40/107 (37%), Positives = 59/107 (55%), Gaps = 10/107 (9%) Query: 315 CCVRPLYIDFRQDLGWK-WVHEPKGYYANFCSGPCPYLRS-----ADTTHSTVLGLY--N 366 CC + ++DFR+ +GW W+ +P+GY NFC G CP + A + H+ VL L N Sbjct: 247 CCRQEFFVDFRE-IGWHDWIIQPEGYAMNFCIGQCPLHIAGMPGIAASFHTAVLNLLKAN 305 Query: 367 TLNPEASASPCCVPQDLEPLTILYYVGRTPKVE-QLSNMVVKSCKCS 412 T CCVP PL++LYY + V+ + +MVV++C CS Sbjct: 306 TAAGTTGGGSCCVPTARRPLSLLYYDRDSNIVKTDIPDMVVEACGCS 352 >gi|110349792 growth differentiation factor 1 [Homo sapiens] Length = 372 Score = 67.8 bits (164), Expect = 2e-11 Identities = 38/106 (35%), Positives = 55/106 (51%), Gaps = 10/106 (9%) Query: 315 CCVRPLYIDFRQDLGW-KWVHEPKGYYANFCSGPC--PYLRSAD-----TTHSTVLGLYN 366 C R LY+ FR+ +GW +WV P+G+ AN+C G C P S H+ + L + Sbjct: 267 CRARRLYVSFRE-VGWHRWVIAPRGFLANYCQGQCALPVALSGSGGPPALNHAVLRALMH 325 Query: 367 TLNPEASASPCCVPQDLEPLTILYYVGRTPKV-EQLSNMVVKSCKC 411 P A+ PCCVP L P+++L++ V Q +MVV C C Sbjct: 326 AAAPGAADLPCCVPARLSPISVLFFDNSDNVVLRQYEDMVVDECGC 371 >gi|126507087 bone morphogenetic protein 3 preproprotein [Homo sapiens] Length = 472 Score = 60.5 bits (145), Expect = 3e-09 Identities = 35/104 (33%), Positives = 56/104 (53%), Gaps = 7/104 (6%) Query: 314 NCCVRPLYIDFRQDLGW-KWVHEPKGYYANFCSGPC--PYLRS-ADTTHSTVLGLYNTLN 369 NC R L +DF D+GW +W+ PK + A +CSG C P +S + H+T+ + + Sbjct: 369 NCARRYLKVDFA-DIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVG 427 Query: 370 -PEASASPCCVPQDLEPLTILYY-VGRTPKVEQLSNMVVKSCKC 411 PCCVP+ + L+IL++ + ++ NM V+SC C Sbjct: 428 VVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCAC 471 >gi|153792495 growth differentiation factor 15 [Homo sapiens] Length = 308 Score = 60.1 bits (144), Expect = 4e-09 Identities = 31/118 (26%), Positives = 51/118 (43%), Gaps = 2/118 (1%) Query: 295 GQRKKRALDTNYCFRNLEENCCVRPLYIDFRQDLGWK-WVHEPKGYYANFCSGPCPYLRS 353 G+R+ RA + ++C CC +DLGW WV P+ C G CP Sbjct: 191 GRRRARARNGDHCPLG-PGRCCRLHTVRASLEDLGWADWVLSPREVQVTMCIGACPSQFR 249 Query: 354 ADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKSCKC 411 A H+ + + L P+ +PCCVP P+ ++ ++ +++ K C C Sbjct: 250 AANMHAQIKTSLHRLKPDTVPAPCCVPASYNPMVLIQKTDTGVSLQTYDDLLAKDCHC 307 >gi|239757187 PREDICTED: similar to growth differentiation factor 15 [Homo sapiens] Length = 270 Score = 60.1 bits (144), Expect = 4e-09 Identities = 31/118 (26%), Positives = 51/118 (43%), Gaps = 2/118 (1%) Query: 295 GQRKKRALDTNYCFRNLEENCCVRPLYIDFRQDLGWK-WVHEPKGYYANFCSGPCPYLRS 353 G+R+ RA + ++C CC +DLGW WV P+ C G CP Sbjct: 153 GRRRARARNGDHCPLG-PGRCCRLHTVRASLEDLGWADWVLSPREVQVTMCIGACPSQFR 211 Query: 354 ADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKSCKC 411 A H+ + + L P+ +PCCVP P+ ++ ++ +++ K C C Sbjct: 212 AANMHAQIKTSLHRLKPDTVPAPCCVPASYNPMVLIQKTDTGVSLQTYDDLLAKDCHC 269 >gi|222352098 nodal precursor [Homo sapiens] Length = 347 Score = 52.8 bits (125), Expect = 6e-07 Identities = 29/94 (30%), Positives = 43/94 (45%), Gaps = 5/94 (5%) Query: 322 IDFRQDLGW-KWVHEPKGYYANFCSGPCPYLRSAD---TTHSTVLGLYNTLNPEASASPC 377 +DF +GW W+ PK Y A C G CP + T H+ + L P S C Sbjct: 254 VDFNL-IGWGSWIIYPKQYNAYRCEGECPNPVGEEFHPTNHAYIQSLLKRYQPHRVPSTC 312 Query: 378 CVPQDLEPLTILYYVGRTPKVEQLSNMVVKSCKC 411 C P +PL++LY ++ +M+V+ C C Sbjct: 313 CAPVKTKPLSMLYVDNGRVLLDHHKDMIVEECGC 346 >gi|4885097 bone morphogenetic protein 15 precursor [Homo sapiens] Length = 392 Score = 52.8 bits (125), Expect = 6e-07 Identities = 32/102 (31%), Positives = 47/102 (46%), Gaps = 6/102 (5%) Query: 315 CCVRPLYIDFRQDLGWK-WVHEPKGYYANFCSGPC-PYLRSA--DTTHSTVLGLYNTLNP 370 C + P I FRQ LGW W+ P Y N+C G C LR H+ + L N L Sbjct: 291 CSLHPFQISFRQ-LGWDHWIIAPPFYTPNYCKGTCLRVLRDGLNSPNHAIIQNLINQLVD 349 Query: 371 EASASPCCVPQDLEPLTILYY-VGRTPKVEQLSNMVVKSCKC 411 ++ P CVP P+++L + ++ M+ +SC C Sbjct: 350 QSVPRPSCVPYKYVPISVLMIEANGSILYKEYEGMIAESCTC 391 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.320 0.136 0.421 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 16,821,970 Number of Sequences: 37866 Number of extensions: 785447 Number of successful extensions: 1817 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 32 Number of HSP's successfully gapped in prelim test: 18 Number of HSP's that attempted gapping in prelim test: 1709 Number of HSP's gapped (non-prelim): 67 length of query: 412 length of database: 18,247,518 effective HSP length: 105 effective length of query: 307 effective length of database: 14,271,588 effective search space: 4381377516 effective search space used: 4381377516 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.