Guide to the Human Genome
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Search of human proteins with 4507465

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4507465 transforming growth factor, beta 3 [Homo sapiens]
         (412 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4507465 transforming growth factor, beta 3 [Homo sapiens]          857   0.0  
gi|4507463 transforming growth factor, beta 2 isoform 2 [Homo sa...   461   e-130
gi|208022653 transforming growth factor, beta 2 isoform 1 [Homo ...   451   e-127
gi|63025222 transforming growth factor, beta 1 [Homo sapiens]         318   7e-87
gi|4885259 myostatin [Homo sapiens]                                   117   1e-26
gi|4504699 inhibin beta A precursor [Homo sapiens]                    106   3e-23
gi|4502427 bone morphogenetic protein 7 precursor [Homo sapiens]      102   8e-22
gi|4502425 bone morphogenetic protein 6 preproprotein [Homo sapi...   102   8e-22
gi|5031613 growth differentiation factor 11 precursor [Homo sapi...    99   7e-21
gi|157276597 bone morphogenetic protein 4 preproprotein [Homo sa...    97   2e-20
gi|157276595 bone morphogenetic protein 4 preproprotein [Homo sa...    97   2e-20
gi|157276593 bone morphogenetic protein 4 preproprotein [Homo sa...    97   2e-20
gi|4557369 bone morphogenetic protein 2 preproprotein [Homo sapi...    94   3e-19
gi|10835091 bone morphogenetic protein 5 preproprotein [Homo sap...    85   1e-16
gi|13899338 activin beta E [Homo sapiens]                              84   2e-16
gi|29571106 bone morphogenetic protein 8B preproprotein [Homo sa...    83   4e-16
gi|145611428 bone morphogenetic protein 8A [Homo sapiens]              83   4e-16
gi|7656928 bone morphogenetic protein 10 preproprotein [Homo sap...    82   1e-15
gi|48475062 growth differentiation factor 6 precursor [Homo sapi...    74   2e-13
gi|61835232 growth differentiation factor 7 preproprotein [Homo ...    72   9e-13
gi|4503969 growth differentiation factor 5 preproprotein [Homo s...    72   1e-12
gi|154813204 inhibin beta B subunit preproprotein [Homo sapiens]       72   1e-12
gi|10190670 growth differentiation factor 3 precursor [Homo sapi...    71   2e-12
gi|5031795 inhibin beta C chain preproprotein [Homo sapiens]           70   3e-12
gi|110349792 growth differentiation factor 1 [Homo sapiens]            68   2e-11
gi|126507087 bone morphogenetic protein 3 preproprotein [Homo sa...    60   3e-09
gi|153792495 growth differentiation factor 15 [Homo sapiens]           60   4e-09
gi|239757187 PREDICTED: similar to growth differentiation factor...    60   4e-09
gi|222352098 nodal precursor [Homo sapiens]                            53   6e-07
gi|4885097 bone morphogenetic protein 15 precursor [Homo sapiens]      53   6e-07

>gi|4507465 transforming growth factor, beta 3 [Homo sapiens]
          Length = 412

 Score =  857 bits (2214), Expect = 0.0
 Identities = 412/412 (100%), Positives = 412/412 (100%)

Query: 1   MKMHLQRALVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLTSPPEPT 60
           MKMHLQRALVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLTSPPEPT
Sbjct: 1   MKMHLQRALVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLTSPPEPT 60

Query: 61  VMTHVPYQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHKFDMIQGLAEHNEL 120
           VMTHVPYQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHKFDMIQGLAEHNEL
Sbjct: 61  VMTHVPYQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHKFDMIQGLAEHNEL 120

Query: 121 AVCPKGITSKVFRFNVSSVEKNRTNLFRAEFRVLRVPNPSSKRNEQRIELFQILRPDEHI 180
           AVCPKGITSKVFRFNVSSVEKNRTNLFRAEFRVLRVPNPSSKRNEQRIELFQILRPDEHI
Sbjct: 121 AVCPKGITSKVFRFNVSSVEKNRTNLFRAEFRVLRVPNPSSKRNEQRIELFQILRPDEHI 180

Query: 181 AKQRYIGGKNLPTRGTAEWLSFDVTDTVREWLLRRESNLGLEISIHCPCHTFQPNGDILE 240
           AKQRYIGGKNLPTRGTAEWLSFDVTDTVREWLLRRESNLGLEISIHCPCHTFQPNGDILE
Sbjct: 181 AKQRYIGGKNLPTRGTAEWLSFDVTDTVREWLLRRESNLGLEISIHCPCHTFQPNGDILE 240

Query: 241 NIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRLDNPGQGGQRKKR 300
           NIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRLDNPGQGGQRKKR
Sbjct: 241 NIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRLDNPGQGGQRKKR 300

Query: 301 ALDTNYCFRNLEENCCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGPCPYLRSADTTHST 360
           ALDTNYCFRNLEENCCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGPCPYLRSADTTHST
Sbjct: 301 ALDTNYCFRNLEENCCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGPCPYLRSADTTHST 360

Query: 361 VLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKSCKCS 412
           VLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKSCKCS
Sbjct: 361 VLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKSCKCS 412


>gi|4507463 transforming growth factor, beta 2 isoform 2 [Homo
           sapiens]
          Length = 414

 Score =  461 bits (1187), Expect = e-130
 Identities = 228/410 (55%), Positives = 294/410 (71%), Gaps = 7/410 (1%)

Query: 9   LVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLTSPPEP-TVMTHVPY 67
           L    +L+  TV+LSLSTC+TLD     +KR+EAIRGQILSKL+LTSPPE       VP 
Sbjct: 6   LSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVPP 65

Query: 68  QVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHKFDMIQGLAEHNELAVCPKGI 127
           +V+++YNSTR+LL+E    R   C +E ++ EYYAKE++K DM       N +       
Sbjct: 66  EVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSENAIPPTFYRP 125

Query: 128 TSKVFRFNVSSVEKNRTNLFRAEFRVLRVPNPSSKRNEQRIELFQILRPDEHIAK-QRYI 186
             ++ RF+VS++EKN +NL +AEFRV R+ NP ++  EQRIEL+QIL+  +  +  QRYI
Sbjct: 126 YFRIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYQILKSKDLTSPTQRYI 185

Query: 187 GGKNLPTRGTAEWLSFDVTDTVREWLLRRESNLGLEISIHCPCHTFQP-NGDILENIHEV 245
             K + TR   EWLSFDVTD V EWL  ++ NLG +IS+HCPC TF P N  I+ N  E 
Sbjct: 186 DSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEE 245

Query: 246 MEIKFKGVDNEDDHGRGDLGRLK---KQKDHHNPHLILMMIPPHRLDNPGQGGQRKKRAL 302
           +E +F G+D    +  GD   +K   K+     PHL+LM++P +RL++  Q  +RKKRAL
Sbjct: 246 LEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQ-QTNRRKKRAL 304

Query: 303 DTNYCFRNLEENCCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGPCPYLRSADTTHSTVL 362
           D  YCFRN+++NCC+RPLYIDF++DLGWKW+HEPKGY ANFC+G CPYL S+DT HS VL
Sbjct: 305 DAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVL 364

Query: 363 GLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKSCKCS 412
            LYNT+NPEASASPCCV QDLEPLTILYY+G+TPK+EQLSNM+VKSCKCS
Sbjct: 365 SLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS 414


>gi|208022653 transforming growth factor, beta 2 isoform 1 [Homo
           sapiens]
          Length = 442

 Score =  451 bits (1161), Expect = e-127
 Identities = 232/441 (52%), Positives = 295/441 (66%), Gaps = 41/441 (9%)

Query: 9   LVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLTSPPEP-TVMTHVPY 67
           L    +L+  TV+LSLSTC+TLD     +KR+EAIRGQILSKL+LTSPPE       VP 
Sbjct: 6   LSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVPP 65

Query: 68  QVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHKFDMIQGLAEHNELAVCPKGI 127
           +V+++YNSTR+LL+E    R   C +E ++ EYYAKE++K DM           VCP   
Sbjct: 66  EVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSE---TVCPVVT 122

Query: 128 TS-------------------------------KVFRFNVSSVEKNRTNLFRAEFRVLRV 156
           T                                ++ RF+VS++EKN +NL +AEFRV R+
Sbjct: 123 TPSGSVGSLCSRQSQVLCGYLDAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRL 182

Query: 157 PNPSSKRNEQRIELFQILR-PDEHIAKQRYIGGKNLPTRGTAEWLSFDVTDTVREWLLRR 215
            NP ++  EQRIEL+QIL+  D     QRYI  K + TR   EWLSFDVTD V EWL  +
Sbjct: 183 QNPKARVPEQRIELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHK 242

Query: 216 ESNLGLEISIHCPCHTFQP-NGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLK---KQK 271
           + NLG +IS+HCPC TF P N  I+ N  E +E +F G+D    +  GD   +K   K+ 
Sbjct: 243 DRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKN 302

Query: 272 DHHNPHLILMMIPPHRLDNPGQGGQRKKRALDTNYCFRNLEENCCVRPLYIDFRQDLGWK 331
               PHL+LM++P +RL++  Q  +RKKRALD  YCFRN+++NCC+RPLYIDF++DLGWK
Sbjct: 303 SGKTPHLLLMLLPSYRLESQ-QTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWK 361

Query: 332 WVHEPKGYYANFCSGPCPYLRSADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYY 391
           W+HEPKGY ANFC+G CPYL S+DT HS VL LYNT+NPEASASPCCV QDLEPLTILYY
Sbjct: 362 WIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYY 421

Query: 392 VGRTPKVEQLSNMVVKSCKCS 412
           +G+TPK+EQLSNM+VKSCKCS
Sbjct: 422 IGKTPKIEQLSNMIVKSCKCS 442


>gi|63025222 transforming growth factor, beta 1 [Homo sapiens]
          Length = 390

 Score =  318 bits (814), Expect = 7e-87
 Identities = 190/410 (46%), Positives = 244/410 (59%), Gaps = 40/410 (9%)

Query: 9   LVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLTSPPEPTVMTH--VP 66
           L+ L +L     +  LSTC T+D   +K+KR+EAIRGQILSKLRL SPP    +    +P
Sbjct: 15  LLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLASPPSQGEVPPGPLP 74

Query: 67  YQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHKFDMIQGLAEHNELAVCPKG 126
             VLALYNSTR+    + GE  E   +   E++YYAKE+ +  M++    HNE+    K 
Sbjct: 75  EAVLALYNSTRD---RVAGESAE--PEPEPEADYYAKEVTRVLMVE---THNEIYDKFKQ 126

Query: 127 ITSKVFRF-NVSSVEK---NRTNLFRAEFRVLRVPNPSSKRNEQRIELFQILRPDEHIAK 182
            T  ++ F N S + +       L RAE R+LR+      + EQ +EL+Q    +     
Sbjct: 127 STHSIYMFFNTSELREAVPEPVLLSRAELRLLRL----KLKVEQHVELYQKYSNNSW--- 179

Query: 183 QRYIGGKNLPTRGTAEWLSFDVTDTVREWLLRRESNLGLEISIHCPCHTFQPNGDILENI 242
            RY+  + L    + EWLSFDVT  VR+WL R     G  +S HC C       D  +N 
Sbjct: 180 -RYLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSC-------DSRDNT 231

Query: 243 HEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRLDNPGQGGQRKKRAL 302
            +V       ++      RGDL  +      + P L+LM  P  R  +      R +RAL
Sbjct: 232 LQV------DINGFTTGRRGDLATIHGM---NRPFLLLMATPLERAQH--LQSSRHRRAL 280

Query: 303 DTNYCFRNLEENCCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGPCPYLRSADTTHSTVL 362
           DTNYCF + E+NCCVR LYIDFR+DLGWKW+HEPKGY+ANFC GPCPY+ S DT +S VL
Sbjct: 281 DTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVL 340

Query: 363 GLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKSCKCS 412
            LYN  NP ASA+PCCVPQ LEPL I+YYVGR PKVEQLSNM+V+SCKCS
Sbjct: 341 ALYNQHNPGASAAPCCVPQALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS 390


>gi|4885259 myostatin [Homo sapiens]
          Length = 375

 Score =  117 bits (294), Expect = 1e-26
 Identities = 102/381 (26%), Positives = 169/381 (44%), Gaps = 58/381 (15%)

Query: 36  KKKRVEAIRGQILSKLRLTSPPEPTVMTHVPYQVLALYNSTRELLEEMHGEREEGCTQEN 95
           K  R+EAI+ QILSKLRL + P   +   V  Q+L      REL+++   +R++      
Sbjct: 49  KSSRIEAIKIQILSKLRLETAPN--ISKDVIRQLLPKAPPLRELIDQYDVQRDDSSDGSL 106

Query: 96  TESEYYAKEIHKFDMIQGLAEHNELAVCPKGITSKVFRFNVSSVEKNRTNLFRAEFRVLR 155
            + +Y+A      + I  +   ++  +   G     F    S ++ N+    +    +  
Sbjct: 107 EDDDYHATT----ETIITMPTESDFLMQVDGKPKCCFFKFSSKIQYNKVVKAQLWIYLRP 162

Query: 156 VPNPSSKRNEQRIELFQILRPDEHIAKQRYIGGKNLP---TRGTAEWLSFDVTDTVREWL 212
           V  P++      +++ ++++P +     RY G ++L      GT  W S DV   ++ WL
Sbjct: 163 VETPTTVF----VQILRLIKPMKD--GTRYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWL 216

Query: 213 LRRESNLGLEISIHCPCHTFQPNGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKD 272
            + ESNLG+EI              + EN H+ + + F G                  +D
Sbjct: 217 KQPESNLGIEIKA------------LDENGHD-LAVTFPGPG----------------ED 247

Query: 273 HHNPHLILMMIPPHRLDNPGQGGQRKKRALDTNYCFRNLEENCCVRPLYIDFRQDLGWKW 332
             NP L + +      D P    +R +R    +    + E  CC  PL +DF +  GW W
Sbjct: 248 GLNPFLEVKVT-----DTP----KRSRRDFGLDCDEHSTESRCCRYPLTVDF-EAFGWDW 297

Query: 333 VHEPKGYYANFCSGPCPYLRSADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYYV 392
           +  PK Y AN+CSG C ++      H+    L +  NP  SA PCC P  + P+ +LY+ 
Sbjct: 298 IIAPKRYKANYCSGECEFVFLQKYPHT---HLVHQANPRGSAGPCCTPTKMSPINMLYFN 354

Query: 393 GRTPKV-EQLSNMVVKSCKCS 412
           G+   +  ++  MVV  C CS
Sbjct: 355 GKEQIIYGKIPAMVVDRCGCS 375


>gi|4504699 inhibin beta A precursor [Homo sapiens]
          Length = 426

 Score =  106 bits (265), Expect = 3e-23
 Identities = 101/407 (24%), Positives = 180/407 (44%), Gaps = 51/407 (12%)

Query: 31  DFGHIKKKRVEAIRGQILSKLRLTSPPEPTVMTHVPYQVLALYNSTRELLEEMHGEREEG 90
           D  + + + VEA++  IL+ L L   P+ T     P    AL N+ R+L          G
Sbjct: 46  DVPNSQPEMVEAVKKHILNMLHLKKRPDVTQ----PVPKAALLNAIRKL--------HVG 93

Query: 91  CTQENTESEYYAKEIHKFDMIQGLAEHNELAV-CPKGITSKVFRFNVSSVEKNRTNLFRA 149
              EN   E       + +M + + + +E+      G   K   F +S    + + + RA
Sbjct: 94  KVGENGYVEIEDDIGRRAEMNELMEQTSEIITFAESGTARKTLHFEISKEGSDLSVVERA 153

Query: 150 E-FRVLRVPNPSSKRNEQRIELFQILRPDEHIA--------------KQRYIGGKNLPTR 194
           E +  L+VP  +  R +  I LFQ  +  +                 +   +  + +   
Sbjct: 154 EVWLFLKVPKANRTRTKVTIRLFQQQKHPQGSLDTGEEAEEVGLKGERSELLLSEKVVDA 213

Query: 195 GTAEWLSFDVTDTVREWLLRRESNLGLEISIHCPCHTFQPNGDILENIHEVMEIKFKGVD 254
             + W  F V+ +++  L + +S+L + I+    C   Q +G  L  + +  + + +G  
Sbjct: 214 RKSTWHVFPVSSSIQRLLDQGKSSLDVRIA----CEQCQESGASLVLLGKKKKKEEEGEG 269

Query: 255 NEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRLDNPGQGGQRKKRALDTNYCFRNLEEN 314
            +   G G  G  ++++  H P L+L        D+P +   R++R L+ +         
Sbjct: 270 KKKGGGEGGAGADEEKEQSHRPFLMLQARQSE--DHPHR---RRRRGLECD----GKVNI 320

Query: 315 CCVRPLYIDFRQDLGWK-WVHEPKGYYANFCSGPCP-----YLRSADTTHSTVLGLYNTL 368
           CC +  ++ F+ D+GW  W+  P GY+AN+C G CP        S+ + HSTV+  Y   
Sbjct: 321 CCKKQFFVSFK-DIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMR 379

Query: 369 --NPEASASPCCVPQDLEPLTILYY-VGRTPKVEQLSNMVVKSCKCS 412
             +P A+   CCVP  L P+++LYY  G+    + + NM+V+ C CS
Sbjct: 380 GHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS 426


>gi|4502427 bone morphogenetic protein 7 precursor [Homo sapiens]
          Length = 431

 Score =  102 bits (253), Expect = 8e-22
 Identities = 105/440 (23%), Positives = 182/440 (41%), Gaps = 70/440 (15%)

Query: 12  LALLNFATVSLSLSTCTTLDFGH--IKKKRVEAIRGQILSKLRLTSPPEPTVM---THVP 66
           L LL  A    SL       F H  ++ +    ++ +ILS L L   P P +       P
Sbjct: 21  LFLLRSALADFSLDNEVHSSFIHRRLRSQERREMQREILSILGLPHRPRPHLQGKHNSAP 80

Query: 67  YQVLALYNSTRELLEEMHGEREEGCTQE-------------NTESEYYAKEIHKFDMIQG 113
             +L LYN+    +EE  G   +G +               + +  ++  +         
Sbjct: 81  MFMLDLYNAMA--VEEGGGPGGQGFSYPYKAVFSTQGPPLASLQDSHFLTDADMVMSFVN 138

Query: 114 LAEHNELAVCPKGITSKVFRFNVSSVEKNRTNLFRAEFRVLRVPNPSSKRNEQ-RIELFQ 172
           L EH++    P+    + FRF++S + +    +  AEFR+ +        NE  RI ++Q
Sbjct: 139 LVEHDKEFFHPR-YHHREFRFDLSKIPEGEA-VTAAEFRIYKDYIRERFDNETFRISVYQ 196

Query: 173 ILRPDEHIAKQRYIGGKNLPTRGTAE--WLSFDVTDTVREWLLRRESNLGLEISIHC--- 227
           +L+  EH+ ++  +   +  T   +E  WL FD+T T   W++    NLGL++S+     
Sbjct: 197 VLQ--EHLGRESDLFLLDSRTLWASEEGWLVFDITATSNHWVVNPRHNLGLQLSVETLDG 254

Query: 228 -----------PCHTFQPNGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNP 276
                        H  Q     +    +  E+ F+ + +     R       + K   N 
Sbjct: 255 QSINPKLAGLIGRHGPQNKQPFMVAFFKATEVHFRSIRSTGSKQRSQ----NRSKTPKNQ 310

Query: 277 HLILMMIPPHRLDNPGQGGQRKKRALDTNYCFRNLEENCCVRPLYIDFRQDLGWK-WVHE 335
             +       R+ N  +     +R            + C    LY+ FR DLGW+ W+  
Sbjct: 311 EAL-------RMANVAENSSSDQR------------QACKKHELYVSFR-DLGWQDWIIA 350

Query: 336 PKGYYANFCSGPCPYLRSA---DTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYYV 392
           P+GY A +C G C +  ++    T H+ V  L + +NPE    PCC P  L  +++LY+ 
Sbjct: 351 PEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPETVPKPCCAPTQLNAISVLYFD 410

Query: 393 GRTPKV-EQLSNMVVKSCKC 411
             +  + ++  NMVV++C C
Sbjct: 411 DSSNVILKKYRNMVVRACGC 430


>gi|4502425 bone morphogenetic protein 6 preproprotein [Homo
           sapiens]
          Length = 513

 Score =  102 bits (253), Expect = 8e-22
 Identities = 78/296 (26%), Positives = 131/296 (44%), Gaps = 21/296 (7%)

Query: 124 PKGITSKVFRFNVSSVEKNRTNLFRAEFRVLRVPNPSSKRNEQ-RIELFQILRPDEHIAK 182
           P+    K F+FN+S + +    +  AEFR+ +     S +N+   I ++Q+L+  +H   
Sbjct: 230 PRQRHHKEFKFNLSQIPEGEV-VTAAEFRIYKDCVMGSFKNQTFLISIYQVLQEHQHRDS 288

Query: 183 QRYIGGKNLPTRGTAEWLSFDVTDTVREWLLRRESNLGLEISIHCPCHTFQPNGDILENI 242
             ++    +       WL FD+T T   W++  + N+GL++S+              + +
Sbjct: 289 DLFLLDTRVVWASEEGWLEFDITATSNLWVVTPQHNMGLQLSVVTR-----------DGV 337

Query: 243 H-EVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRLDNPGQGGQRKKRA 301
           H         G D   D     +   K  + H             +  N     Q   R 
Sbjct: 338 HVHPRAAGLVGRDGPYDKQPFMVAFFKVSEVHVRTTRSASSRRRQQSRNRSTQSQDVARV 397

Query: 302 LD-TNYCFRNLEENCCVRPLYIDFRQDLGWK-WVHEPKGYYANFCSGPCPYLRSAD---T 356
              ++Y    L+  C    LY+ F QDLGW+ W+  PKGY AN+C G C +  +A    T
Sbjct: 398 SSASDYNSSELKTACRKHELYVSF-QDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNAT 456

Query: 357 THSTVLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKV-EQLSNMVVKSCKC 411
            H+ V  L + +NPE    PCC P  L  +++LY+   +  + ++  NMVV++C C
Sbjct: 457 NHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYFDDNSNVILKKYRNMVVRACGC 512


>gi|5031613 growth differentiation factor 11 precursor [Homo
           sapiens]
          Length = 407

 Score = 99.0 bits (245), Expect = 7e-21
 Identities = 104/399 (26%), Positives = 165/399 (41%), Gaps = 81/399 (20%)

Query: 34  HIKKKRVEAIRGQILSKLRLTSPPEPTVMTHVPYQVLALYNSTRELLEEMHGEREEGCTQ 93
           H ++ R+E+I+ QILSKLRL   P   +   V  Q+L      +++L+ +H  + +    
Sbjct: 70  HSRELRLESIKSQILSKLRLKEAPN--ISREVVKQLLPKAPPLQQILD-LHDFQGDALQP 126

Query: 94  EN--TESEYYAKEIHKFDMIQGLAEHNELAVCPKGITSKVFRFNVSSVEKNRTNLFRAEF 151
           E+   E EY+A      + +  +A+  + AV   G +     F+ S  +   T + +A+ 
Sbjct: 127 EDFLEEDEYHATT----ETVISMAQETDPAVQTDG-SPLCCHFHFSP-KVMFTKVLKAQL 180

Query: 152 RV-LR-VPNPSSKRNEQRIELFQILRPDEHIAKQRYIGG----KNLPTRG--------TA 197
            V LR VP P++          QILR      +    GG    +++  R         + 
Sbjct: 181 WVYLRPVPRPATV-------YLQILRLKPLTGEGTAGGGGGGRRHIRIRSLKIELHSRSG 233

Query: 198 EWLSFDVTDTVREWLLRRESNLGLEISIHCPCHT---FQPNGDILENIHEVMEIKFKGVD 254
            W S D    +  W  + +SN G+EI+   P  T       G   E +H  ME++     
Sbjct: 234 HWQSIDFKQVLHSWFRQPQSNWGIEINAFDPSGTDLAVTSLGPGAEGLHPFMELRV---- 289

Query: 255 NEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRLDNPGQGGQRKKRALDTNYCFRNLEEN 314
                                            L+N     +R +R L  +    + E  
Sbjct: 290 ---------------------------------LENT----KRSRRNLGLDCDEHSSESR 312

Query: 315 CCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGPCPYLRSADTTHSTVLGLYNTLNPEASA 374
           CC  PL +DF +  GW W+  PK Y AN+CSG C Y+      H+    L    NP  SA
Sbjct: 313 CCRYPLTVDF-EAFGWDWIIAPKRYKANYCSGQCEYMFMQKYPHT---HLVQQANPRGSA 368

Query: 375 SPCCVPQDLEPLTILYYVGRTPKV-EQLSNMVVKSCKCS 412
            PCC P  + P+ +LY+  +   +  ++  MVV  C CS
Sbjct: 369 GPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGCS 407


>gi|157276597 bone morphogenetic protein 4 preproprotein [Homo
           sapiens]
          Length = 408

 Score = 97.4 bits (241), Expect = 2e-20
 Identities = 98/384 (25%), Positives = 161/384 (41%), Gaps = 56/384 (14%)

Query: 47  ILSKLRLTSPPEPTVMTHVPYQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIH 106
           +L    L   P+P+    +P       +  R+L     GE EE     +T  EY  +   
Sbjct: 61  LLQMFGLRRRPQPSKSAVIP-------DYMRDLYRLQSGEEEEEQIH-STGLEYPERPAS 112

Query: 107 KFDMIQGLAEHNELAVCPKGITSKVFRF--NVSSVEKNRTNLFRAEFRVLRVP---NPSS 161
           + + ++       L   P    +  FRF  N+SS+ +N   +  AE R+ R      P  
Sbjct: 113 RANTVRSFHHEEHLENIPGTSENSAFRFLFNLSSIPENEV-ISSAELRLFREQVDQGPDW 171

Query: 162 KRNEQRIELFQILRPDEHIAKQRYIGGKNLPTR----GTAEWLSFDVTDTVREWLLRRES 217
           +R   RI ++++++P   +     I  + L TR        W +FDV+  V  W   ++ 
Sbjct: 172 ERGFHRINIYEVMKPPAEVVPGHLIT-RLLDTRLVHHNVTRWETFDVSPAVLRWTREKQP 230

Query: 218 NLGLEISIHCPCHTFQPNGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPH 277
           N GL I +    H  Q         H+   ++   +      G G+  +L+         
Sbjct: 231 NYGLAIEV---THLHQTR------THQGQHVR---ISRSLPQGSGNWAQLRP-------- 270

Query: 278 LILMMIPPHRLDNPGQGGQRKKRALDT----NYCFRNLEENCCVRPLYIDFRQDLGWK-W 332
             L++   H  D  G    R++RA  +    +   R   +NC    LY+DF  D+GW  W
Sbjct: 271 --LLVTFGH--DGRGHALTRRRRAKRSPKHHSQRARKKNKNCRRHSLYVDF-SDVGWNDW 325

Query: 333 VHEPKGYYANFCSGPCPYLRS---ADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTIL 389
           +  P GY A +C G CP+  +     T H+ V  L N++N  +    CCVP +L  +++L
Sbjct: 326 IVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVN-SSIPKACCVPTELSAISML 384

Query: 390 YYVGRTPKV--EQLSNMVVKSCKC 411
            Y+    KV  +    MVV+ C C
Sbjct: 385 -YLDEYDKVVLKNYQEMVVEGCGC 407


>gi|157276595 bone morphogenetic protein 4 preproprotein [Homo
           sapiens]
          Length = 408

 Score = 97.4 bits (241), Expect = 2e-20
 Identities = 98/384 (25%), Positives = 161/384 (41%), Gaps = 56/384 (14%)

Query: 47  ILSKLRLTSPPEPTVMTHVPYQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIH 106
           +L    L   P+P+    +P       +  R+L     GE EE     +T  EY  +   
Sbjct: 61  LLQMFGLRRRPQPSKSAVIP-------DYMRDLYRLQSGEEEEEQIH-STGLEYPERPAS 112

Query: 107 KFDMIQGLAEHNELAVCPKGITSKVFRF--NVSSVEKNRTNLFRAEFRVLRVP---NPSS 161
           + + ++       L   P    +  FRF  N+SS+ +N   +  AE R+ R      P  
Sbjct: 113 RANTVRSFHHEEHLENIPGTSENSAFRFLFNLSSIPENEV-ISSAELRLFREQVDQGPDW 171

Query: 162 KRNEQRIELFQILRPDEHIAKQRYIGGKNLPTR----GTAEWLSFDVTDTVREWLLRRES 217
           +R   RI ++++++P   +     I  + L TR        W +FDV+  V  W   ++ 
Sbjct: 172 ERGFHRINIYEVMKPPAEVVPGHLIT-RLLDTRLVHHNVTRWETFDVSPAVLRWTREKQP 230

Query: 218 NLGLEISIHCPCHTFQPNGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPH 277
           N GL I +    H  Q         H+   ++   +      G G+  +L+         
Sbjct: 231 NYGLAIEV---THLHQTR------THQGQHVR---ISRSLPQGSGNWAQLRP-------- 270

Query: 278 LILMMIPPHRLDNPGQGGQRKKRALDT----NYCFRNLEENCCVRPLYIDFRQDLGWK-W 332
             L++   H  D  G    R++RA  +    +   R   +NC    LY+DF  D+GW  W
Sbjct: 271 --LLVTFGH--DGRGHALTRRRRAKRSPKHHSQRARKKNKNCRRHSLYVDF-SDVGWNDW 325

Query: 333 VHEPKGYYANFCSGPCPYLRS---ADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTIL 389
           +  P GY A +C G CP+  +     T H+ V  L N++N  +    CCVP +L  +++L
Sbjct: 326 IVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVN-SSIPKACCVPTELSAISML 384

Query: 390 YYVGRTPKV--EQLSNMVVKSCKC 411
            Y+    KV  +    MVV+ C C
Sbjct: 385 -YLDEYDKVVLKNYQEMVVEGCGC 407


>gi|157276593 bone morphogenetic protein 4 preproprotein [Homo
           sapiens]
          Length = 408

 Score = 97.4 bits (241), Expect = 2e-20
 Identities = 98/384 (25%), Positives = 161/384 (41%), Gaps = 56/384 (14%)

Query: 47  ILSKLRLTSPPEPTVMTHVPYQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIH 106
           +L    L   P+P+    +P       +  R+L     GE EE     +T  EY  +   
Sbjct: 61  LLQMFGLRRRPQPSKSAVIP-------DYMRDLYRLQSGEEEEEQIH-STGLEYPERPAS 112

Query: 107 KFDMIQGLAEHNELAVCPKGITSKVFRF--NVSSVEKNRTNLFRAEFRVLRVP---NPSS 161
           + + ++       L   P    +  FRF  N+SS+ +N   +  AE R+ R      P  
Sbjct: 113 RANTVRSFHHEEHLENIPGTSENSAFRFLFNLSSIPENEV-ISSAELRLFREQVDQGPDW 171

Query: 162 KRNEQRIELFQILRPDEHIAKQRYIGGKNLPTR----GTAEWLSFDVTDTVREWLLRRES 217
           +R   RI ++++++P   +     I  + L TR        W +FDV+  V  W   ++ 
Sbjct: 172 ERGFHRINIYEVMKPPAEVVPGHLIT-RLLDTRLVHHNVTRWETFDVSPAVLRWTREKQP 230

Query: 218 NLGLEISIHCPCHTFQPNGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPH 277
           N GL I +    H  Q         H+   ++   +      G G+  +L+         
Sbjct: 231 NYGLAIEV---THLHQTR------THQGQHVR---ISRSLPQGSGNWAQLRP-------- 270

Query: 278 LILMMIPPHRLDNPGQGGQRKKRALDT----NYCFRNLEENCCVRPLYIDFRQDLGWK-W 332
             L++   H  D  G    R++RA  +    +   R   +NC    LY+DF  D+GW  W
Sbjct: 271 --LLVTFGH--DGRGHALTRRRRAKRSPKHHSQRARKKNKNCRRHSLYVDF-SDVGWNDW 325

Query: 333 VHEPKGYYANFCSGPCPYLRS---ADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTIL 389
           +  P GY A +C G CP+  +     T H+ V  L N++N  +    CCVP +L  +++L
Sbjct: 326 IVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVN-SSIPKACCVPTELSAISML 384

Query: 390 YYVGRTPKV--EQLSNMVVKSCKC 411
            Y+    KV  +    MVV+ C C
Sbjct: 385 -YLDEYDKVVLKNYQEMVVEGCGC 407


>gi|4557369 bone morphogenetic protein 2 preproprotein [Homo
           sapiens]
          Length = 396

 Score = 93.6 bits (231), Expect = 3e-19
 Identities = 96/382 (25%), Positives = 164/382 (42%), Gaps = 58/382 (15%)

Query: 46  QILSKLRLTSPPEPTVMTHVPYQVLALY--NSTRELLEEMHGEREEGCTQENTESEYYAK 103
           ++LS   L   P P+    VP  +L LY  +S +          E   ++ NT      +
Sbjct: 56  RLLSMFGLKQRPTPSRDAVVPPYMLDLYRRHSGQPGSPAPDHRLERAASRANT-----VR 110

Query: 104 EIHKFDMIQGLAEHNELAVCPKGITSKVFRFNVSSVEKNRTNLFRAEFRVLRVPNPSSKR 163
             H  + ++ L E +       G T++ F FN+SS+      +  AE +V R     +  
Sbjct: 111 SFHHEESLEELPETS-------GKTTRRFFFNLSSIPTEEF-ITSAELQVFREQMQDALG 162

Query: 164 NEQ----RIELFQILRPDEHIAKQRYIGGKNLPTR----GTAEWLSFDVTDTVREWLLRR 215
           N      RI +++I++P    A  ++   + L TR      + W SFDVT  V  W  + 
Sbjct: 163 NNSSFHHRINIYEIIKPAT--ANSKFPVTRLLDTRLVNQNASRWESFDVTPAVMRWTAQG 220

Query: 216 ESNLGLEISIHCPCHTFQPNGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHN 275
            +N G  + +    H  +  G    ++     +      ++D+H    +  L     H  
Sbjct: 221 HANHGFVVEV---AHLEEKQGVSKRHVRISRSL------HQDEHSWSQIRPLLVTFGHDG 271

Query: 276 PHLILMMIPPHRLDNPGQGGQRKKRALDTNYCFRNLEENCCVRPLYIDFRQDLGWK-WVH 334
                   P H+ +      +++KR          L+ +C   PLY+DF  D+GW  W+ 
Sbjct: 272 KGH-----PLHKREKRQAKHKQRKR----------LKSSCKRHPLYVDF-SDVGWNDWIV 315

Query: 335 EPKGYYANFCSGPCPYLRS---ADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYY 391
            P GY+A +C G CP+  +     T H+ V  L N++N +   + CCVP +L  +++L Y
Sbjct: 316 APPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNSKIPKA-CCVPTELSAISML-Y 373

Query: 392 VGRTPKV--EQLSNMVVKSCKC 411
           +    KV  +   +MVV+ C C
Sbjct: 374 LDENEKVVLKNYQDMVVEGCGC 395


>gi|10835091 bone morphogenetic protein 5 preproprotein [Homo
           sapiens]
          Length = 454

 Score = 85.1 bits (209), Expect = 1e-16
 Identities = 75/303 (24%), Positives = 132/303 (43%), Gaps = 48/303 (15%)

Query: 130 KVFRFNVSSVEKNRTNLFRAEFRVLRVPNPSSKRNEQ-RIELFQILRPDEHIAKQRYIGG 188
           K FRF+++ +      +  AEFR+ +  + +   NE  +I ++QI++   +     ++  
Sbjct: 178 KEFRFDLTQIPHGEA-VTAAEFRIYKDRSNNRFENETIKISIYQIIKEYTNRDADLFLLD 236

Query: 189 KNLPTRGTAEWLSFDVTDTVREWLLRRESNLGLEISIHCPCHTFQPNGDILENIHEVMEI 248
                     WL FD+T T   W++  ++NLGL++            GD        + +
Sbjct: 237 TRKAQALDVGWLVFDITVTSNHWVINPQNNLGLQLCAE--------TGD-----GRSINV 283

Query: 249 KFKGVDNEDDHGRGDLGRLKKQKDHHNPHLIL------MMIPPHRLDNPGQGGQRKKRAL 302
           K  G+        G  G   KQ     P ++       +++   R  N  +   R K + 
Sbjct: 284 KSAGLV-------GRQGPQSKQ-----PFMVAFFKASEVLLRSVRAANKRKNQNRNKSSS 331

Query: 303 DTN---------YCFRNLEENCCVRPLYIDFRQDLGWK-WVHEPKGYYANFCSGPCPYLR 352
             +         Y     ++ C    LY+ FR DLGW+ W+  P+GY A +C G C +  
Sbjct: 332 HQDSSRMSSVGDYNTSEQKQACKKHELYVSFR-DLGWQDWIIAPEGYAAFYCDGECSFPL 390

Query: 353 SAD---TTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKV-EQLSNMVVKS 408
           +A    T H+ V  L + + P+    PCC P  L  +++LY+   +  + ++  NMVV+S
Sbjct: 391 NAHMNATNHAIVQTLVHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRS 450

Query: 409 CKC 411
           C C
Sbjct: 451 CGC 453


>gi|13899338 activin beta E [Homo sapiens]
          Length = 350

 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 58/159 (36%), Positives = 82/159 (51%), Gaps = 19/159 (11%)

Query: 262 GDLGRLKKQKDHHNPHLILMMIPPHRLDNPGQGGQRKKRALDTNYCFRNLEENCCVRPLY 321
           G   RL     H  P L L +    R + PG G  R++    T  C       CC R  Y
Sbjct: 203 GQPRRLLDTAGHQQPFLELKI----RANEPGAGRARRR----TPTC-EPATPLCCRRDHY 253

Query: 322 IDFRQDLGWK-WVHEPKGYYANFCSGPC-PYLRS----ADTTHSTVLGLYNTLNPEASAS 375
           +DF Q+LGW+ W+ +P+GY  N+CSG C P+L      A + HS V  L    NP  +++
Sbjct: 254 VDF-QELGWRDWILQPEGYQLNYCSGQCPPHLAGSPGIAASFHSAVFSLLKANNPWPAST 312

Query: 376 PCCVPQDLEPLTILY--YVGRTPKVEQLSNMVVKSCKCS 412
            CCVP    PL++LY  + G   K + + +MVV++C CS
Sbjct: 313 SCCVPTARRPLSLLYLDHNGNVVKTD-VPDMVVEACGCS 350


>gi|29571106 bone morphogenetic protein 8B preproprotein [Homo
           sapiens]
          Length = 402

 Score = 83.2 bits (204), Expect = 4e-16
 Identities = 72/294 (24%), Positives = 118/294 (40%), Gaps = 30/294 (10%)

Query: 130 KVFRFNVSSVEKNRTNLFRAEFRVLRVPNPSSKRNEQRIELFQILRPDEHIAKQRYIGGK 189
           K FRF+++ +      +  AEFR+ +VP+         + +FQ+++   +     +    
Sbjct: 126 KEFRFDLTQIPAGEA-VTAAEFRIYKVPSIHLLNRTLHVSMFQVVQEQSNRESDLFFLDL 184

Query: 190 NLPTRGTAEWLSFDVTDTVREWLLRRESNLGLEISIHCPC-HTFQPN-----GDILENIH 243
                G   WL  DVT     WLL+R  +LGL + +     H+  P      G       
Sbjct: 185 QTLRAGDEGWLVLDVTAASDCWLLKRHKDLGLRLYVETEDGHSVDPGLAGLLGQRAPRSQ 244

Query: 244 EVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRLDNP-GQGGQRKKRAL 302
           +   + F             +  L++++   +  L      P   D+  G  G++     
Sbjct: 245 QPFVVTFFRASPSPIRTPRAVRPLRRRQPKKSNELPQANRLPGIFDDVHGSHGRQV---- 300

Query: 303 DTNYCFRNLEENCCVRPLYIDFRQDLGW-KWVHEPKGYYANFCSGPCPYLRSA---DTTH 358
                       C    LY+ F QDLGW  WV  P+GY A +C G C +   +    T H
Sbjct: 301 ------------CRRHELYVSF-QDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNH 347

Query: 359 STVLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKV-EQLSNMVVKSCKC 411
           + +  L + + P+A    CC P  L   ++LYY      +  +  NMVVK+C C
Sbjct: 348 AILQSLVHLMMPDAVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGC 401


>gi|145611428 bone morphogenetic protein 8A [Homo sapiens]
          Length = 402

 Score = 83.2 bits (204), Expect = 4e-16
 Identities = 72/294 (24%), Positives = 117/294 (39%), Gaps = 30/294 (10%)

Query: 130 KVFRFNVSSVEKNRTNLFRAEFRVLRVPNPSSKRNEQRIELFQILRPDEHIAKQRYIGGK 189
           K FRF+++ +      +  AEFR+ +VP+         + +FQ+++   +     +    
Sbjct: 126 KEFRFDLTQIPAGEA-VTAAEFRIYKVPSIHLLNRTLHVSMFQVVQEQSNRESDLFFLDL 184

Query: 190 NLPTRGTAEWLSFDVTDTVREWLLRRESNLGLEISIHCPC-HTFQPN-----GDILENIH 243
                G   WL  DVT     WLL+R  +LGL + +     H+  P      G       
Sbjct: 185 QTLRAGDEGWLVLDVTAASDCWLLKRHKDLGLRLYVETEDGHSVDPGLAGLLGQRAPRSQ 244

Query: 244 EVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRLDNP-GQGGQRKKRAL 302
           +   + F             +  L++++   +  L      P   D+  G  G++     
Sbjct: 245 QPFVVTFFRASPSPIRTPRAVRPLRRRQPKKSNELPQANRLPGIFDDVRGSHGRQV---- 300

Query: 303 DTNYCFRNLEENCCVRPLYIDFRQDLGW-KWVHEPKGYYANFCSGPCPYLRSA---DTTH 358
                       C    LY+ F QDLGW  WV  P+GY A +C G C +   +    T H
Sbjct: 301 ------------CRRHELYVSF-QDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNH 347

Query: 359 STVLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKV-EQLSNMVVKSCKC 411
           + +  L + + P A    CC P  L   ++LYY      +  +  NMVVK+C C
Sbjct: 348 AILQSLVHLMKPNAVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGC 401


>gi|7656928 bone morphogenetic protein 10 preproprotein [Homo
           sapiens]
          Length = 424

 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 75/277 (27%), Positives = 116/277 (41%), Gaps = 45/277 (16%)

Query: 165 EQRIELFQILRPDEHIAKQR----YIGGKNLPTRGTAEWLSFDVTDTVREWLLRRESNLG 220
           +++I +F++L        +R     + G+   T   +EW +FDVTD +R W     S   
Sbjct: 162 DRKITIFEVLESKGDNEGERNMLVLVSGEIYGTN--SEWETFDVTDAIRRWQKSGSSTHQ 219

Query: 221 LEISIHCPCHTFQPNGD-------ILENIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDH 273
           LE+ I       +             +N H  + I F    + D          K++K+ 
Sbjct: 220 LEVHIESKHDEAEDASSGRLEIDTSAQNKHNPLLIVFSDDQSSD----------KERKEE 269

Query: 274 HNPHLILMMIPPHRLDNPGQG------GQRKKRALDTNYCF-------RNLEENCCVR-P 319
            N  +    +P   LDN G        G+     + +N  +       RN + N C R P
Sbjct: 270 LNEMISHEQLP--ELDNLGLDSFSSGPGEEALLQMRSNIIYDSTARIRRNAKGNYCKRTP 327

Query: 320 LYIDFRQDLGW-KWVHEPKGYYANFCSGPCPYLRS---ADTTHSTVLGLYNTLNPEASAS 375
           LYIDF++ +GW  W+  P GY A  C G C Y  +     T H+ +  L +  N + ++ 
Sbjct: 328 LYIDFKE-IGWDSWIIAPPGYEAYECRGVCNYPLAEHLTPTKHAIIQALVHLKNSQKASK 386

Query: 376 PCCVPQDLEPLTILYY-VGRTPKVEQLSNMVVKSCKC 411
            CCVP  LEP++ILY   G      +   M V  C C
Sbjct: 387 ACCVPTKLEPISILYLDKGVVTYKFKYEGMAVSECGC 423


>gi|48475062 growth differentiation factor 6 precursor [Homo
           sapiens]
          Length = 455

 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 44/129 (34%), Positives = 73/129 (56%), Gaps = 9/129 (6%)

Query: 291 PGQGGQRKKRALDTNYCFRNLEEN---CCVRPLYIDFRQDLGWK-WVHEPKGYYANFCSG 346
           P  G +R++ A  + +  R+ +++   C  +PL+++F++ LGW  W+  P  Y A  C G
Sbjct: 327 PSPGRRRRRTAFASRHGKRHGKKSRLRCSKKPLHVNFKE-LGWDDWIIAPLEYEAYHCEG 385

Query: 347 PCPY-LRS--ADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYY-VGRTPKVEQLS 402
            C + LRS    T H+ +  L N+++P ++   CCVP  L P++ILY   G     +Q  
Sbjct: 386 VCDFPLRSHLEPTNHAIIQTLMNSMDPGSTPPSCCVPTKLTPISILYIDAGNNVVYKQYE 445

Query: 403 NMVVKSCKC 411
           +MVV+SC C
Sbjct: 446 DMVVESCGC 454


>gi|61835232 growth differentiation factor 7 preproprotein [Homo
           sapiens]
          Length = 450

 Score = 72.0 bits (175), Expect = 9e-13
 Identities = 41/108 (37%), Positives = 61/108 (56%), Gaps = 6/108 (5%)

Query: 309 RNLEENCCVRPLYIDFRQDLGWK-WVHEPKGYYANFCSGPCPY-LRS--ADTTHSTVLGL 364
           R     C  +PL++DF++ LGW  W+  P  Y A  C G C + LRS    T H+ +  L
Sbjct: 343 RRGRSRCSRKPLHVDFKE-LGWDDWIIAPLDYEAYHCEGLCDFPLRSHLEPTNHAIIQTL 401

Query: 365 YNTLNPEASASPCCVPQDLEPLTILYYVGRTPKV-EQLSNMVVKSCKC 411
            N++ P+A+ + CCVP  L P++ILY       V +Q  +MVV++C C
Sbjct: 402 LNSMAPDAAPASCCVPARLSPISILYIDAANNVVYKQYEDMVVEACGC 449


>gi|4503969 growth differentiation factor 5 preproprotein [Homo
           sapiens]
          Length = 501

 Score = 71.6 bits (174), Expect = 1e-12
 Identities = 40/108 (37%), Positives = 63/108 (58%), Gaps = 6/108 (5%)

Query: 309 RNLEENCCVRPLYIDFRQDLGWK-WVHEPKGYYANFCSGPCPY-LRS--ADTTHSTVLGL 364
           +NL+  C  + L+++F+ D+GW  W+  P  Y A  C G C + LRS    T H+ +  L
Sbjct: 394 KNLKARCSRKALHVNFK-DMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTL 452

Query: 365 YNTLNPEASASPCCVPQDLEPLTILYYVGRTPKV-EQLSNMVVKSCKC 411
            N+++PE++   CCVP  L P++IL+       V +Q  +MVV+SC C
Sbjct: 453 MNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGC 500


>gi|154813204 inhibin beta B subunit preproprotein [Homo sapiens]
          Length = 407

 Score = 71.6 bits (174), Expect = 1e-12
 Identities = 40/107 (37%), Positives = 61/107 (57%), Gaps = 11/107 (10%)

Query: 315 CCVRPLYIDFRQDLGWK-WVHEPKGYYANFCSGPCP-YLR----SADTTHSTVLGLYNT- 367
           CC +  +IDFR  +GW  W+  P GYY N+C G CP YL     SA + H+ V+  Y   
Sbjct: 303 CCRQQFFIDFRL-IGWNDWIIAPTGYYGNYCEGSCPAYLAGVPGSASSFHTAVVNQYRMR 361

Query: 368 -LNPEASASPCCVPQDLEPLTILYYVGRTPKVEQ-LSNMVVKSCKCS 412
            LNP  + + CC+P  L  +++LY+      V++ + NM+V+ C C+
Sbjct: 362 GLNP-GTVNSCCIPTKLSTMSMLYFDDEYNIVKRDVPNMIVEECGCA 407


>gi|10190670 growth differentiation factor 3 precursor [Homo
           sapiens]
          Length = 364

 Score = 70.9 bits (172), Expect = 2e-12
 Identities = 90/386 (23%), Positives = 150/386 (38%), Gaps = 74/386 (19%)

Query: 48  LSKLRLTSPPEPTVMTHVPYQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHK 107
           L  L L   P P     VPY           +L+++  +RE   T   +    Y KE+  
Sbjct: 30  LQFLGLDKAPSPQKFQPVPY-----------ILKKIFQDREAAATTGVSRDLCYVKELGV 78

Query: 108 FDMIQGLAEHNELAVCPKGITS------KVFRFNVSSVEKNRTNLFRAEFRVLRVPNPSS 161
              +          + PK I+       K+  FN+S++ K R  L  A+  +   PN   
Sbjct: 79  RGNVLRFLPDQGFFLYPKKISQASSCLQKLLYFNLSAI-KEREQLTLAQLGLDLGPNSYY 137

Query: 162 KRN-EQRIELFQILRPDEHIAKQRYIGGKNLPTRG------TAEW----LSFDVTDTVRE 210
               E  + LF +  P        ++ G+  P  G      +  W    + F++ D  ++
Sbjct: 138 NLGPELELALFLVQEP--------HVWGQTTPKPGKMFVLRSVPWPQGAVHFNLLDVAKD 189

Query: 211 WLLRRESNLGLEISIHCPCHTFQPNGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLKKQ 270
           W      N GL + I                   V E +  GV+ + +       RL+  
Sbjct: 190 WNDNPRKNFGLFLEIL------------------VKEDRDSGVNFQPED---TCARLRCS 228

Query: 271 KDHHNPHLILMMIPPHRLDNPGQGGQRKKRALDTNYCFRNLEENCCVRPLYIDFRQDLGW 330
                 H  L+++      NP Q    +KR         + +  C    L+I+FR DLGW
Sbjct: 229 L-----HASLLVVTL----NPDQCHPSRKRRAAIPVPKLSCKNLCHRHQLFINFR-DLGW 278

Query: 331 -KWVHEPKGYYANFCSGPCPY---LRSADTTHSTVLGLYNTLNPEASASPCCVPQDLEPL 386
            KW+  PKG+ AN+C G CP+   +    + ++ +  L + ++PE   +  C+P  L P+
Sbjct: 279 HKWIIAPKGFMANYCHGECPFSLTISLNSSNYAFMQALMHAVDPEIPQA-VCIPTKLSPI 337

Query: 387 TILYYVGRTPKV-EQLSNMVVKSCKC 411
           ++LY       +     +MVV  C C
Sbjct: 338 SMLYQDNNDNVILRHYEDMVVDECGC 363


>gi|5031795 inhibin beta C chain preproprotein [Homo sapiens]
          Length = 352

 Score = 70.1 bits (170), Expect = 3e-12
 Identities = 40/107 (37%), Positives = 59/107 (55%), Gaps = 10/107 (9%)

Query: 315 CCVRPLYIDFRQDLGWK-WVHEPKGYYANFCSGPCPYLRS-----ADTTHSTVLGLY--N 366
           CC +  ++DFR+ +GW  W+ +P+GY  NFC G CP   +     A + H+ VL L   N
Sbjct: 247 CCRQEFFVDFRE-IGWHDWIIQPEGYAMNFCIGQCPLHIAGMPGIAASFHTAVLNLLKAN 305

Query: 367 TLNPEASASPCCVPQDLEPLTILYYVGRTPKVE-QLSNMVVKSCKCS 412
           T         CCVP    PL++LYY   +  V+  + +MVV++C CS
Sbjct: 306 TAAGTTGGGSCCVPTARRPLSLLYYDRDSNIVKTDIPDMVVEACGCS 352


>gi|110349792 growth differentiation factor 1 [Homo sapiens]
          Length = 372

 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 38/106 (35%), Positives = 55/106 (51%), Gaps = 10/106 (9%)

Query: 315 CCVRPLYIDFRQDLGW-KWVHEPKGYYANFCSGPC--PYLRSAD-----TTHSTVLGLYN 366
           C  R LY+ FR+ +GW +WV  P+G+ AN+C G C  P   S         H+ +  L +
Sbjct: 267 CRARRLYVSFRE-VGWHRWVIAPRGFLANYCQGQCALPVALSGSGGPPALNHAVLRALMH 325

Query: 367 TLNPEASASPCCVPQDLEPLTILYYVGRTPKV-EQLSNMVVKSCKC 411
              P A+  PCCVP  L P+++L++      V  Q  +MVV  C C
Sbjct: 326 AAAPGAADLPCCVPARLSPISVLFFDNSDNVVLRQYEDMVVDECGC 371


>gi|126507087 bone morphogenetic protein 3 preproprotein [Homo
           sapiens]
          Length = 472

 Score = 60.5 bits (145), Expect = 3e-09
 Identities = 35/104 (33%), Positives = 56/104 (53%), Gaps = 7/104 (6%)

Query: 314 NCCVRPLYIDFRQDLGW-KWVHEPKGYYANFCSGPC--PYLRS-ADTTHSTVLGLYNTLN 369
           NC  R L +DF  D+GW +W+  PK + A +CSG C  P  +S   + H+T+  +   + 
Sbjct: 369 NCARRYLKVDFA-DIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVG 427

Query: 370 -PEASASPCCVPQDLEPLTILYY-VGRTPKVEQLSNMVVKSCKC 411
                  PCCVP+ +  L+IL++   +   ++   NM V+SC C
Sbjct: 428 VVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCAC 471


>gi|153792495 growth differentiation factor 15 [Homo sapiens]
          Length = 308

 Score = 60.1 bits (144), Expect = 4e-09
 Identities = 31/118 (26%), Positives = 51/118 (43%), Gaps = 2/118 (1%)

Query: 295 GQRKKRALDTNYCFRNLEENCCVRPLYIDFRQDLGWK-WVHEPKGYYANFCSGPCPYLRS 353
           G+R+ RA + ++C       CC         +DLGW  WV  P+      C G CP    
Sbjct: 191 GRRRARARNGDHCPLG-PGRCCRLHTVRASLEDLGWADWVLSPREVQVTMCIGACPSQFR 249

Query: 354 ADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKSCKC 411
           A   H+ +    + L P+   +PCCVP    P+ ++        ++   +++ K C C
Sbjct: 250 AANMHAQIKTSLHRLKPDTVPAPCCVPASYNPMVLIQKTDTGVSLQTYDDLLAKDCHC 307


>gi|239757187 PREDICTED: similar to growth differentiation factor 15
           [Homo sapiens]
          Length = 270

 Score = 60.1 bits (144), Expect = 4e-09
 Identities = 31/118 (26%), Positives = 51/118 (43%), Gaps = 2/118 (1%)

Query: 295 GQRKKRALDTNYCFRNLEENCCVRPLYIDFRQDLGWK-WVHEPKGYYANFCSGPCPYLRS 353
           G+R+ RA + ++C       CC         +DLGW  WV  P+      C G CP    
Sbjct: 153 GRRRARARNGDHCPLG-PGRCCRLHTVRASLEDLGWADWVLSPREVQVTMCIGACPSQFR 211

Query: 354 ADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKSCKC 411
           A   H+ +    + L P+   +PCCVP    P+ ++        ++   +++ K C C
Sbjct: 212 AANMHAQIKTSLHRLKPDTVPAPCCVPASYNPMVLIQKTDTGVSLQTYDDLLAKDCHC 269


>gi|222352098 nodal precursor [Homo sapiens]
          Length = 347

 Score = 52.8 bits (125), Expect = 6e-07
 Identities = 29/94 (30%), Positives = 43/94 (45%), Gaps = 5/94 (5%)

Query: 322 IDFRQDLGW-KWVHEPKGYYANFCSGPCPYLRSAD---TTHSTVLGLYNTLNPEASASPC 377
           +DF   +GW  W+  PK Y A  C G CP     +   T H+ +  L     P    S C
Sbjct: 254 VDFNL-IGWGSWIIYPKQYNAYRCEGECPNPVGEEFHPTNHAYIQSLLKRYQPHRVPSTC 312

Query: 378 CVPQDLEPLTILYYVGRTPKVEQLSNMVVKSCKC 411
           C P   +PL++LY       ++   +M+V+ C C
Sbjct: 313 CAPVKTKPLSMLYVDNGRVLLDHHKDMIVEECGC 346


>gi|4885097 bone morphogenetic protein 15 precursor [Homo sapiens]
          Length = 392

 Score = 52.8 bits (125), Expect = 6e-07
 Identities = 32/102 (31%), Positives = 47/102 (46%), Gaps = 6/102 (5%)

Query: 315 CCVRPLYIDFRQDLGWK-WVHEPKGYYANFCSGPC-PYLRSA--DTTHSTVLGLYNTLNP 370
           C + P  I FRQ LGW  W+  P  Y  N+C G C   LR       H+ +  L N L  
Sbjct: 291 CSLHPFQISFRQ-LGWDHWIIAPPFYTPNYCKGTCLRVLRDGLNSPNHAIIQNLINQLVD 349

Query: 371 EASASPCCVPQDLEPLTILYY-VGRTPKVEQLSNMVVKSCKC 411
           ++   P CVP    P+++L      +   ++   M+ +SC C
Sbjct: 350 QSVPRPSCVPYKYVPISVLMIEANGSILYKEYEGMIAESCTC 391


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.136    0.421 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,821,970
Number of Sequences: 37866
Number of extensions: 785447
Number of successful extensions: 1817
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 32
Number of HSP's successfully gapped in prelim test: 18
Number of HSP's that attempted gapping in prelim test: 1709
Number of HSP's gapped (non-prelim): 67
length of query: 412
length of database: 18,247,518
effective HSP length: 105
effective length of query: 307
effective length of database: 14,271,588
effective search space: 4381377516
effective search space used: 4381377516
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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