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Search of human proteins with 4506931
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4506931 SH3-domain GRB2-like 2 [Homo sapiens]
(352 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4506931 SH3-domain GRB2-like 2 [Homo sapiens] 705 0.0
gi|4506929 SH3-domain GRB2-like 1 [Homo sapiens] 520 e-147
gi|223468657 SH3-domain GRB2-like 3 [Homo sapiens] 488 e-138
gi|7705773 SH3-containing protein SH3GLB1 [Homo sapiens] 112 7e-25
gi|9910352 SH3-domain GRB2-like endophilin B2 [Homo sapiens] 97 2e-20
gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens] 75 9e-14
gi|151108509 Rho GTPase-activating protein RICH2 [Homo sapiens] 71 2e-12
gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens] 69 8e-12
gi|54860079 nadrin isoform 1 [Homo sapiens] 65 7e-11
gi|54860105 nadrin isoform 2 [Homo sapiens] 65 7e-11
gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens] 65 9e-11
gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens] 65 9e-11
gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens] 65 9e-11
gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Hom... 65 1e-10
gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo ... 65 1e-10
gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo ... 65 1e-10
gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo ... 65 1e-10
gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo ... 65 1e-10
gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo ... 65 1e-10
gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo ... 65 1e-10
gi|45359859 growth factor receptor-bound protein 2 isoform 2 [Ho... 65 1e-10
gi|89886447 nitric oxide synthase trafficker isoform 2 [Homo sap... 65 1e-10
gi|16418431 nitric oxide synthase trafficker isoform 1 [Homo sap... 65 1e-10
gi|67514036 SH3-domain kinase binding protein 1 isoform b [Homo ... 65 1e-10
gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo ... 65 1e-10
gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo s... 65 1e-10
gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo ... 65 1e-10
gi|222446607 SH3 domain containing ring finger 2 [Homo sapiens] 64 2e-10
gi|167234422 hematopoietic cell-specific Lyn substrate 1 [Homo s... 61 2e-09
gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo ... 60 2e-09
>gi|4506931 SH3-domain GRB2-like 2 [Homo sapiens]
Length = 352
Score = 705 bits (1819), Expect = 0.0
Identities = 352/352 (100%), Positives = 352/352 (100%)
Query: 1 MSVAGLKKQFHKATQKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQP 60
MSVAGLKKQFHKATQKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQP
Sbjct: 1 MSVAGLKKQFHKATQKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQP 60
Query: 61 NPASRAKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEA 120
NPASRAKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEA
Sbjct: 61 NPASRAKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEA 120
Query: 121 MRELSEVKDSLDIEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQGKIPD 180
MRELSEVKDSLDIEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQGKIPD
Sbjct: 121 MRELSEVKDSLDIEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQGKIPD 180
Query: 181 EELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRL 240
EELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRL
Sbjct: 181 EELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRL 240
Query: 241 EERIRQASSQPRREYQPKPRMSLEFPTGDSTQPNGGLSHTGTPKPSGVQMDQPCCRALYD 300
EERIRQASSQPRREYQPKPRMSLEFPTGDSTQPNGGLSHTGTPKPSGVQMDQPCCRALYD
Sbjct: 241 EERIRQASSQPRREYQPKPRMSLEFPTGDSTQPNGGLSHTGTPKPSGVQMDQPCCRALYD 300
Query: 301 FEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVEILVALPH 352
FEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVEILVALPH
Sbjct: 301 FEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVEILVALPH 352
>gi|4506929 SH3-domain GRB2-like 1 [Homo sapiens]
Length = 368
Score = 520 bits (1338), Expect = e-147
Identities = 262/369 (71%), Positives = 305/369 (82%), Gaps = 20/369 (5%)
Query: 1 MSVAGLKKQFHKATQKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQP 60
MSVAGLKKQF+KA+Q VSEKVGGAEGTKLDDDFKEME+KVDVTS+AV E++ +TIEYLQP
Sbjct: 1 MSVAGLKKQFYKASQLVSEKVGGAEGTKLDDDFKEMEKKVDVTSKAVTEVLARTIEYLQP 60
Query: 61 NPASRAKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEA 120
NPASRAKL+M+NT+SKIRGQ K PGYPQ+E LL E M++ G+ELG + NFG AL + GE+
Sbjct: 61 NPASRAKLTMLNTVSKIRGQVKNPGYPQSEGLLGECMIRHGKELGGESNFGDALLDAGES 120
Query: 121 MRELSEVKDSLDIEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQGKIPD 180
M+ L+EVKDSLDIEVKQNFIDPLQNL +KDL+EIQHHLKKLEGRRLDFDYKKKRQGKIPD
Sbjct: 121 MKRLAEVKDSLDIEVKQNFIDPLQNLCEKDLKEIQHHLKKLEGRRLDFDYKKKRQGKIPD 180
Query: 181 EELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRL 240
EELRQALEKF+ESKE+AE+SM NLLE DIEQVSQLSALV AQL+YH+QAVQIL ++ +L
Sbjct: 181 EELRQALEKFEESKEVAETSMHNLLETDIEQVSQLSALVDAQLDYHRQAVQILDELAEKL 240
Query: 241 EERIRQASSQPRREYQPKPRMSLEFPTGDSTQPNGGLSHT------------------GT 282
+ R+R+ASS+P+REY+PKPR F G+ Q NGG T T
Sbjct: 241 KRRMREASSRPKREYKPKPRE--PFDLGEPEQSNGGFPCTTAPKIAASSSFRSSDKPIRT 298
Query: 283 PKPSGVQMDQPCCRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPIN 342
P S +DQP C+ALYDFEPEN+GELGF EGD+ITLTNQIDENWYEGML G SGFFP++
Sbjct: 299 PSRSMPPLDQPSCKALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLS 358
Query: 343 YVEILVALP 351
YVE+LV LP
Sbjct: 359 YVEVLVPLP 367
>gi|223468657 SH3-domain GRB2-like 3 [Homo sapiens]
Length = 347
Score = 488 bits (1256), Expect = e-138
Identities = 241/353 (68%), Positives = 288/353 (81%), Gaps = 9/353 (2%)
Query: 1 MSVAGLKKQFHKATQKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQP 60
MSVAGLKKQFHKA+Q SEK+ GAEGTKLDD+F +MERK+DVT++ V EI++KT EYLQP
Sbjct: 1 MSVAGLKKQFHKASQLFSEKISGAEGTKLDDEFLDMERKIDVTNKVVAEILSKTTEYLQP 60
Query: 61 NPASRAKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEA 120
NPA RAKL M+NT+SKIRGQ K GYPQ E LL + MLK+G+ELG+D FG AL EVGE+
Sbjct: 61 NPAYRAKLGMLNTVSKIRGQVKTTGYPQTEGLLGDCMLKYGKELGEDSTFGNALIEVGES 120
Query: 121 MRELSEVKDSLDIEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQGKIPD 180
M+ ++EVKDSLDI VKQ FIDPLQ L DKDL+EI HHLKKLEGRRLD+DYKKKR GKIPD
Sbjct: 121 MKLMAEVKDSLDINVKQTFIDPLQLLQDKDLKEIGHHLKKLEGRRLDYDYKKKRVGKIPD 180
Query: 181 EELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRL 240
EE+RQA+EKF+ESKE+AE SMFN LE D+EQVSQL+ ++A L+YH+Q+ +ILQ++ +L
Sbjct: 181 EEVRQAVEKFEESKELAERSMFNFLENDVEQVSQLAVFIEAALDYHRQSTEILQELQSKL 240
Query: 241 EERIRQASSQPRREYQPKPRMSLEFPTGDSTQPNGGLSHTGTPKPSG--VQMDQPCCRAL 298
+ RI ASS PRREY+P+ P S+ G+S T K +G + MDQPCCR L
Sbjct: 241 QMRISAASSVPRREYKPR-------PVKRSSSELNGVSTTSVVKTTGSNIPMDQPCCRGL 293
Query: 299 YDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVEILVALP 351
YDFEPEN+GELGFKEGDIITLTNQIDENWYEGM+HG SGFFPINYVE++V LP
Sbjct: 294 YDFEPENQGELGFKEGDIITLTNQIDENWYEGMIHGESGFFPINYVEVIVPLP 346
>gi|7705773 SH3-containing protein SH3GLB1 [Homo sapiens]
Length = 365
Score = 112 bits (279), Expect = 7e-25
Identities = 92/352 (26%), Positives = 146/352 (41%), Gaps = 24/352 (6%)
Query: 12 KATQKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQPNPASRAKLSMI 71
+A Q EK+G AE T+LD + + K + T +IM +T LQPNP +R + +
Sbjct: 21 RAVQFTEEKLGQAEKTELDAHLENLLSKAECTKIWTEKIMKQTEVLLQPNPNARIEEFVY 80
Query: 72 NTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEAMRELSEVKDSL 131
+ + K P LL + M+ G E G +G AL + GE + + L
Sbjct: 81 EKLDR-----KAPSRINNPELLGQYMIDAGTEFGPGTAYGNALIKCGETQKRIGTADREL 135
Query: 132 DIEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQGKI--------PDEEL 183
NF+ PL+N + D + I K L+ +RLD D K R K ++EL
Sbjct: 136 IQTSALNFLTPLRNFIEGDYKTIAKERKLLQNKRLDLDAAKTRLKKAKAAETRNSSEQEL 195
Query: 184 RQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRLEE- 242
R +FD EI + + + L+ V+AQ+ Y+ Q Q + + +L
Sbjct: 196 RITQSEFDRQAEITRLLLEGISSTHAHHLRCLNDFVEAQMTYYAQCYQYMLDLQKQLGSF 255
Query: 243 RIRQASSQPRREYQPKPRMSLEFPTGDSTQPNGGLSHTGTPKPSGVQMDQPC-----CRA 297
S+ + P P + P + S PS + + C R
Sbjct: 256 PSNYLSNNNQTSVTPVPSV---LPNAIGSSAMASTSGLVITSPSNLSDLKECSGSRKARV 312
Query: 298 LYDFEPENEGELGFKEGDIITLTNQI--DENWYEGMLHGHSGFFPINYVEIL 347
LYD++ N EL ++IT+ + + D +W G G PI Y+E+L
Sbjct: 313 LYDYDAANSTELSLLADEVITVFSVVGMDSDWLMGERGNQKGKVPITYLELL 364
>gi|9910352 SH3-domain GRB2-like endophilin B2 [Homo sapiens]
Length = 395
Score = 97.1 bits (240), Expect = 2e-20
Identities = 95/388 (24%), Positives = 153/388 (39%), Gaps = 59/388 (15%)
Query: 10 FHKATQKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQPNPASRAKLS 69
F +A Q EK G AE T+LD F+ + + D T +I+ +T LQPNP++R +
Sbjct: 16 FTRAVQFTEEKFGQAEKTELDAHFENLLARADSTKNWTEKILRQTEVLLQPNPSARVEEF 75
Query: 70 MINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEAMRELSEVKD 129
+ + + K P LLA+ M ELG +G L +V EA ++L +
Sbjct: 76 LYEKLDR-----KVPSRVTNGELLAQYMADAASELGPTTPYGKTLIKVAEAEKQLGAAER 130
Query: 130 SLDIEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQGK----------IP 179
+F+ PL+N + D + I + L+ RRLD D K R K +P
Sbjct: 131 DFIHTASISFLTPLRNFLEGDWKTISKERRLLQNRRLDLDACKARLKKAKAAEAKATTVP 190
Query: 180 D---------------------------EELRQALEKFDESKEIAESSMFNLLEMDIEQV 212
D +ELR A +FD E+ + + + +
Sbjct: 191 DFQETRPRNYILSASASALWNDEVDKAEQELRVAQTEFDRQAEVTRLLLEGISSTHVNHL 250
Query: 213 SQLSALVQAQLEYHKQAVQILQQVTVRLEE------RIRQASSQPRREYQPKPRMSL--E 264
L V++Q Y+ Q + + + +L + +S P P +
Sbjct: 251 RCLHEFVKSQTTYYAQCYRHMLDLQKQLGRFPGTFVGTTEPASPPLSSTSPTTAAATMPV 310
Query: 265 FPTGDSTQPNGGLS---HTGTPKPSGVQMDQPCCRALYDFEPENEGELGFKEGDIITLTN 321
P+ S P G S P SG + R LYD+E + EL ++IT+ +
Sbjct: 311 VPSVASLAPPGEASLCLEEVAPPASGTRK----ARVLYDYEAADSSELALLADELITVYS 366
Query: 322 --QIDENWYEGMLHGHSGFFPINYVEIL 347
+D +W G G P+ Y+E+L
Sbjct: 367 LPGMDPDWLIGERGNKKGKVPVTYLELL 394
>gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens]
Length = 888
Score = 75.1 bits (183), Expect = 9e-14
Identities = 31/59 (52%), Positives = 43/59 (72%)
Query: 293 PCCRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVEILVALP 351
PC +ALY++E + G+L F +GDII L Q+DENWY G ++G GFFP N+V+I+ LP
Sbjct: 137 PCAKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIHGFFPTNFVQIIKPLP 195
Score = 57.4 bits (137), Expect = 2e-08
Identities = 27/57 (47%), Positives = 38/57 (66%), Gaps = 4/57 (7%)
Query: 293 PCCRALYDFEPENEGE----LGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVE 345
P C+ALYDFE +++ L F + D++T+ ++DENW EGML G FPI+YVE
Sbjct: 199 PQCKALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAEGMLADKIGIFPISYVE 255
Score = 44.3 bits (103), Expect = 2e-04
Identities = 19/52 (36%), Positives = 34/52 (65%), Gaps = 2/52 (3%)
Query: 296 RALYDFEPENEGELGFKEGDIITLTNQIDENWYEGML--HGHSGFFPINYVE 345
R + + P++E EL KEGDI+ + + ++ W++G L +G +G FP ++VE
Sbjct: 835 RVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVE 886
Score = 35.4 bits (80), Expect = 0.077
Identities = 16/50 (32%), Positives = 27/50 (54%), Gaps = 2/50 (4%)
Query: 297 ALYDFEPENEGELGFKEGDIITLTNQIDENWYEG--MLHGHSGFFPINYV 344
A+Y + P E EL ++G++ + + + W++G M G FP NYV
Sbjct: 452 AIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYV 501
>gi|151108509 Rho GTPase-activating protein RICH2 [Homo sapiens]
Length = 818
Score = 70.9 bits (172), Expect = 2e-12
Identities = 58/256 (22%), Positives = 117/256 (45%), Gaps = 35/256 (13%)
Query: 6 LKKQFHKATQKVSEKVGGAEGTK-LDDDFKEMERKVDVTSRAVMEIMTKTIEYLQPNPAS 64
+KKQF++ Q ++ VG AE T+ L +D ++E+++++ + K LQ +
Sbjct: 1 MKKQFNRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGA 60
Query: 65 RAKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEAMREL 124
A + +K P LA+ +++ LGDD G L GE +L
Sbjct: 61 EAD----------KRSKKLP-----LTTLAQCLMEGSAILGDDTLLGKMLKLCGETEDKL 105
Query: 125 SEVKDSLDIEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKR---------- 174
++ +++V+++ I+PL L + ++ IQ K L LD D + R
Sbjct: 106 AQELIHFELQVERDVIEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGL 165
Query: 175 ------QGKIPD---EELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEY 225
G D EE+ +A + + ++ + M++ + +I+ + L++ Q EY
Sbjct: 166 SSSLQPAGAKADALREEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTLIEVQAEY 225
Query: 226 HKQAVQILQQVTVRLE 241
H++++ +LQ V +++
Sbjct: 226 HRKSLTLLQAVLPQIK 241
>gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens]
Length = 882
Score = 68.6 bits (166), Expect = 8e-12
Identities = 28/60 (46%), Positives = 39/60 (65%)
Query: 293 PCCRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVEILVALPH 352
P +ALY +E + G+L F +GDII L ++DE WY G LHG GF P +Y++ + LPH
Sbjct: 197 PYGKALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPLPH 256
Score = 51.6 bits (122), Expect = 1e-06
Identities = 25/58 (43%), Positives = 38/58 (65%), Gaps = 4/58 (6%)
Query: 293 PCCRALYDFEPENEGE----LGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVEI 346
P +ALYDFE +++ + L F + +I+T+ ++DENW EGML G FP+ YVE+
Sbjct: 259 PQGKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFPLLYVEL 316
Score = 45.4 bits (106), Expect = 7e-05
Identities = 19/52 (36%), Positives = 34/52 (65%), Gaps = 2/52 (3%)
Query: 296 RALYDFEPENEGELGFKEGDIITLTNQIDENWYEGML--HGHSGFFPINYVE 345
R + + P++E E+ KEGDI+ + + ++ WY+G L +G +G FP ++VE
Sbjct: 829 RVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
Score = 42.4 bits (98), Expect = 6e-04
Identities = 36/145 (24%), Positives = 64/145 (44%), Gaps = 23/145 (15%)
Query: 221 AQLEYHKQAVQILQQVTVRLEERIRQASSQPRREYQ--PKPRMSLEFPTGDSTQPNGGLS 278
+Q H+ +++I V + +SS PR + +S PT D + + G +
Sbjct: 392 SQAASHRHSMEISAPVLI--------SSSDPRAAARIGDLAHLSCAAPTQDVSS-SAGST 442
Query: 279 HTGTPK----------PSGVQMDQPCCRALYDFEPENEGELGFKEGDIITLTNQIDENWY 328
T P+ P VQ+ ALY ++P+ EL +G++ + + + W+
Sbjct: 443 PTAVPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWF 502
Query: 329 EG--MLHGHSGFFPINYVEILVALP 351
+G + G SG FP NYV + +P
Sbjct: 503 KGASLRTGVSGVFPGNYVTPVSRVP 527
>gi|54860079 nadrin isoform 1 [Homo sapiens]
Length = 881
Score = 65.5 bits (158), Expect = 7e-11
Identities = 58/248 (23%), Positives = 113/248 (45%), Gaps = 34/248 (13%)
Query: 6 LKKQFHKATQKVSEKVGGAEGTK-LDDDFKEMERKVDVTSRAVMEIMTKTIEYLQPNPAS 64
+KKQF++ Q ++ VG AE T+ L +D ++ER++D + + Q +
Sbjct: 1 MKKQFNRMKQLANQTVGRAEKTEVLSEDLLQIERRLDTVRSICHHSHKRLVACFQGQHGT 60
Query: 65 RAKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEAMREL 124
A+ R +K P LA+ M + +L +D G L G+A +L
Sbjct: 61 DAE----------RRHKKLP-----LTALAQNMQEASTQL-EDSLLGKMLETCGDAENQL 104
Query: 125 SEVKDSLDIEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQGK------- 177
+ ++ V++ +DPL + + ++ IQ K+L LD+D + R +
Sbjct: 105 ALELSQHEVFVEKEIVDPLYGIAEVEIPNIQKQRKQLARLVLDWDSVRARWNQAHKSSGT 164
Query: 178 ----IPD------EELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHK 227
+P EE+ +A K ++ K+ + M+N + + E L++AQ +YH+
Sbjct: 165 NFQGLPSKIDTLKEEMDEAGNKVEQCKDQLAADMYNFMAKEGEYGKFFVTLLEAQADYHR 224
Query: 228 QAVQILQQ 235
+A+ +L++
Sbjct: 225 KALAVLEK 232
>gi|54860105 nadrin isoform 2 [Homo sapiens]
Length = 803
Score = 65.5 bits (158), Expect = 7e-11
Identities = 58/248 (23%), Positives = 113/248 (45%), Gaps = 34/248 (13%)
Query: 6 LKKQFHKATQKVSEKVGGAEGTK-LDDDFKEMERKVDVTSRAVMEIMTKTIEYLQPNPAS 64
+KKQF++ Q ++ VG AE T+ L +D ++ER++D + + Q +
Sbjct: 1 MKKQFNRMKQLANQTVGRAEKTEVLSEDLLQIERRLDTVRSICHHSHKRLVACFQGQHGT 60
Query: 65 RAKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEAMREL 124
A+ R +K P LA+ M + +L +D G L G+A +L
Sbjct: 61 DAE----------RRHKKLP-----LTALAQNMQEASTQL-EDSLLGKMLETCGDAENQL 104
Query: 125 SEVKDSLDIEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQGK------- 177
+ ++ V++ +DPL + + ++ IQ K+L LD+D + R +
Sbjct: 105 ALELSQHEVFVEKEIVDPLYGIAEVEIPNIQKQRKQLARLVLDWDSVRARWNQAHKSSGT 164
Query: 178 ----IPD------EELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHK 227
+P EE+ +A K ++ K+ + M+N + + E L++AQ +YH+
Sbjct: 165 NFQGLPSKIDTLKEEMDEAGNKVEQCKDQLAADMYNFMAKEGEYGKFFVTLLEAQADYHR 224
Query: 228 QAVQILQQ 235
+A+ +L++
Sbjct: 225 KALAVLEK 232
>gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]
Length = 731
Score = 65.1 bits (157), Expect = 9e-11
Identities = 29/52 (55%), Positives = 35/52 (67%)
Query: 296 RALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVEIL 347
+ALYDF ENE EL FK GDIIT +D++W G L G SG FP NY++ L
Sbjct: 677 KALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 728
Score = 54.3 bits (129), Expect = 2e-07
Identities = 26/74 (35%), Positives = 37/74 (50%), Gaps = 4/74 (5%)
Query: 278 SHTGTPKPSGVQMDQPCCRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSG 337
SH P SG P L+DF E +L G+I+ L +ID +WY G G
Sbjct: 428 SHAQKPVDSGA----PHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIG 483
Query: 338 FFPINYVEILVALP 351
FP NYV++++ +P
Sbjct: 484 IFPANYVKVIIDIP 497
Score = 51.6 bits (122), Expect = 1e-06
Identities = 21/51 (41%), Positives = 32/51 (62%)
Query: 295 CRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVE 345
C A +++ E + EL F EG+II L ++E W G + G +G FP+N+VE
Sbjct: 517 CVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVE 567
Score = 45.4 bits (106), Expect = 7e-05
Identities = 19/50 (38%), Positives = 26/50 (52%)
Query: 295 CRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYV 344
C AL+ F E +L FK GD I + ++D +W G L G FP +V
Sbjct: 607 CEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFV 656
>gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]
Length = 767
Score = 65.1 bits (157), Expect = 9e-11
Identities = 29/52 (55%), Positives = 35/52 (67%)
Query: 296 RALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVEIL 347
+ALYDF ENE EL FK GDIIT +D++W G L G SG FP NY++ L
Sbjct: 713 KALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 764
Score = 54.3 bits (129), Expect = 2e-07
Identities = 26/74 (35%), Positives = 37/74 (50%), Gaps = 4/74 (5%)
Query: 278 SHTGTPKPSGVQMDQPCCRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSG 337
SH P SG P L+DF E +L G+I+ L +ID +WY G G
Sbjct: 464 SHAQKPVDSGA----PHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIG 519
Query: 338 FFPINYVEILVALP 351
FP NYV++++ +P
Sbjct: 520 IFPANYVKVIIDIP 533
Score = 51.6 bits (122), Expect = 1e-06
Identities = 21/51 (41%), Positives = 32/51 (62%)
Query: 295 CRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVE 345
C A +++ E + EL F EG+II L ++E W G + G +G FP+N+VE
Sbjct: 553 CVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVE 603
Score = 45.4 bits (106), Expect = 7e-05
Identities = 19/50 (38%), Positives = 26/50 (52%)
Query: 295 CRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYV 344
C AL+ F E +L FK GD I + ++D +W G L G FP +V
Sbjct: 643 CEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFV 692
>gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens]
Length = 790
Score = 65.1 bits (157), Expect = 9e-11
Identities = 29/52 (55%), Positives = 35/52 (67%)
Query: 296 RALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVEIL 347
+ALYDF ENE EL FK GDIIT +D++W G L G SG FP NY++ L
Sbjct: 736 KALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 787
Score = 54.3 bits (129), Expect = 2e-07
Identities = 26/74 (35%), Positives = 37/74 (50%), Gaps = 4/74 (5%)
Query: 278 SHTGTPKPSGVQMDQPCCRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSG 337
SH P SG P L+DF E +L G+I+ L +ID +WY G G
Sbjct: 487 SHAQKPVDSGA----PHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIG 542
Query: 338 FFPINYVEILVALP 351
FP NYV++++ +P
Sbjct: 543 IFPANYVKVIIDIP 556
Score = 51.6 bits (122), Expect = 1e-06
Identities = 21/51 (41%), Positives = 32/51 (62%)
Query: 295 CRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVE 345
C A +++ E + EL F EG+II L ++E W G + G +G FP+N+VE
Sbjct: 576 CVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVE 626
Score = 45.4 bits (106), Expect = 7e-05
Identities = 19/50 (38%), Positives = 26/50 (52%)
Query: 295 CRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYV 344
C AL+ F E +L FK GD I + ++D +W G L G FP +V
Sbjct: 666 CEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFV 715
Score = 32.3 bits (72), Expect = 0.66
Identities = 19/70 (27%), Positives = 32/70 (45%)
Query: 281 GTPKPSGVQMDQPCCRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFP 340
G P S + P A D +N GEL K GD++ + Q + N+ E +G
Sbjct: 406 GHPLYSKYMLSVPHGIANEDIVSQNPGELSCKRGDVLVMLKQTENNYLECQKGEDTGRVH 465
Query: 341 INYVEILVAL 350
++ ++I+ L
Sbjct: 466 LSQMKIITPL 475
>gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Homo
sapiens]
Length = 217
Score = 64.7 bits (156), Expect = 1e-10
Identities = 25/49 (51%), Positives = 36/49 (73%)
Query: 296 RALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYV 344
+AL+DF+P+ +GELGF+ GD I + + D NW++G HG +G FP NYV
Sbjct: 162 QALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYV 210
Score = 54.7 bits (130), Expect = 1e-07
Identities = 24/51 (47%), Positives = 34/51 (66%), Gaps = 1/51 (1%)
Query: 297 ALYDFEPENEGELGFKEGDIITLTNQ-IDENWYEGMLHGHSGFFPINYVEI 346
A YDF+ + EL FK GDI+ + N+ D+NWY+ L+G GF P NY+E+
Sbjct: 5 AKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEM 55
>gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo
sapiens]
Length = 492
Score = 64.7 bits (156), Expect = 1e-10
Identities = 27/52 (51%), Positives = 37/52 (71%)
Query: 296 RALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVEIL 347
+A+YDF+ + EL FK+GD + + +ID+NWYEG HG G FPI+YVE L
Sbjct: 261 KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL 312
Score = 51.6 bits (122), Expect = 1e-06
Identities = 21/53 (39%), Positives = 34/53 (64%), Gaps = 2/53 (3%)
Query: 297 ALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHG--HSGFFPINYVEIL 347
A Y+F + EL ++GD + L ++D+NWYEG + G G FP++YVE++
Sbjct: 337 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 389
Score = 43.1 bits (100), Expect = 4e-04
Identities = 21/54 (38%), Positives = 31/54 (57%), Gaps = 2/54 (3%)
Query: 296 RALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHS--GFFPINYVEIL 347
+ALY++ P NE EL +E D+I + + D+ W+ G G FP NYV+ L
Sbjct: 439 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 492
>gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo
sapiens]
Length = 1004
Score = 64.7 bits (156), Expect = 1e-10
Identities = 27/52 (51%), Positives = 37/52 (71%)
Query: 296 RALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVEIL 347
+A+YDF+ + EL FK+GD + + +ID+NWYEG HG G FPI+YVE L
Sbjct: 773 KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL 824
Score = 51.6 bits (122), Expect = 1e-06
Identities = 21/53 (39%), Positives = 34/53 (64%), Gaps = 2/53 (3%)
Query: 297 ALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHG--HSGFFPINYVEIL 347
A Y+F + EL ++GD + L ++D+NWYEG + G G FP++YVE++
Sbjct: 849 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 901
Score = 43.1 bits (100), Expect = 4e-04
Identities = 21/54 (38%), Positives = 31/54 (57%), Gaps = 2/54 (3%)
Query: 296 RALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHS--GFFPINYVEIL 347
+ALY++ P NE EL +E D+I + + D+ W+ G G FP NYV+ L
Sbjct: 951 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1004
>gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo
sapiens]
Length = 824
Score = 64.7 bits (156), Expect = 1e-10
Identities = 27/52 (51%), Positives = 37/52 (71%)
Query: 296 RALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVEIL 347
+A+YDF+ + EL FK+GD + + +ID+NWYEG HG G FPI+YVE L
Sbjct: 593 KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL 644
Score = 51.6 bits (122), Expect = 1e-06
Identities = 21/53 (39%), Positives = 34/53 (64%), Gaps = 2/53 (3%)
Query: 297 ALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHG--HSGFFPINYVEIL 347
A Y+F + EL ++GD + L ++D+NWYEG + G G FP++YVE++
Sbjct: 669 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 721
Score = 43.1 bits (100), Expect = 4e-04
Identities = 21/54 (38%), Positives = 31/54 (57%), Gaps = 2/54 (3%)
Query: 296 RALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHS--GFFPINYVEIL 347
+ALY++ P NE EL +E D+I + + D+ W+ G G FP NYV+ L
Sbjct: 771 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 824
>gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo
sapiens]
Length = 661
Score = 64.7 bits (156), Expect = 1e-10
Identities = 27/52 (51%), Positives = 37/52 (71%)
Query: 296 RALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVEIL 347
+A+YDF+ + EL FK+GD + + +ID+NWYEG HG G FPI+YVE L
Sbjct: 430 KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL 481
Score = 51.6 bits (122), Expect = 1e-06
Identities = 21/53 (39%), Positives = 34/53 (64%), Gaps = 2/53 (3%)
Query: 297 ALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHG--HSGFFPINYVEIL 347
A Y+F + EL ++GD + L ++D+NWYEG + G G FP++YVE++
Sbjct: 506 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 558
Score = 43.1 bits (100), Expect = 4e-04
Identities = 21/54 (38%), Positives = 31/54 (57%), Gaps = 2/54 (3%)
Query: 296 RALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHS--GFFPINYVEIL 347
+ALY++ P NE EL +E D+I + + D+ W+ G G FP NYV+ L
Sbjct: 608 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 661
>gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo
sapiens]
Length = 731
Score = 64.7 bits (156), Expect = 1e-10
Identities = 27/52 (51%), Positives = 37/52 (71%)
Query: 296 RALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVEIL 347
+A+YDF+ + EL FK+GD + + +ID+NWYEG HG G FPI+YVE L
Sbjct: 500 KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL 551
Score = 51.6 bits (122), Expect = 1e-06
Identities = 21/53 (39%), Positives = 34/53 (64%), Gaps = 2/53 (3%)
Query: 297 ALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHG--HSGFFPINYVEIL 347
A Y+F + EL ++GD + L ++D+NWYEG + G G FP++YVE++
Sbjct: 576 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 628
Score = 43.1 bits (100), Expect = 4e-04
Identities = 21/54 (38%), Positives = 31/54 (57%), Gaps = 2/54 (3%)
Query: 296 RALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHS--GFFPINYVEIL 347
+ALY++ P NE EL +E D+I + + D+ W+ G G FP NYV+ L
Sbjct: 678 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 731
>gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo
sapiens]
Length = 644
Score = 64.7 bits (156), Expect = 1e-10
Identities = 27/52 (51%), Positives = 37/52 (71%)
Query: 296 RALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVEIL 347
+A+YDF+ + EL FK+GD + + +ID+NWYEG HG G FPI+YVE L
Sbjct: 413 KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL 464
Score = 51.6 bits (122), Expect = 1e-06
Identities = 21/53 (39%), Positives = 34/53 (64%), Gaps = 2/53 (3%)
Query: 297 ALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHG--HSGFFPINYVEIL 347
A Y+F + EL ++GD + L ++D+NWYEG + G G FP++YVE++
Sbjct: 489 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 541
Score = 43.1 bits (100), Expect = 4e-04
Identities = 21/54 (38%), Positives = 31/54 (57%), Gaps = 2/54 (3%)
Query: 296 RALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHS--GFFPINYVEIL 347
+ALY++ P NE EL +E D+I + + D+ W+ G G FP NYV+ L
Sbjct: 591 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 644
>gi|45359859 growth factor receptor-bound protein 2 isoform 2 [Homo
sapiens]
Length = 176
Score = 64.7 bits (156), Expect = 1e-10
Identities = 25/49 (51%), Positives = 36/49 (73%)
Query: 296 RALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYV 344
+AL+DF+P+ +GELGF+ GD I + + D NW++G HG +G FP NYV
Sbjct: 121 QALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYV 169
Score = 54.7 bits (130), Expect = 1e-07
Identities = 24/51 (47%), Positives = 34/51 (66%), Gaps = 1/51 (1%)
Query: 297 ALYDFEPENEGELGFKEGDIITLTNQ-IDENWYEGMLHGHSGFFPINYVEI 346
A YDF+ + EL FK GDI+ + N+ D+NWY+ L+G GF P NY+E+
Sbjct: 5 AKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEM 55
>gi|89886447 nitric oxide synthase trafficker isoform 2 [Homo
sapiens]
Length = 506
Score = 64.7 bits (156), Expect = 1e-10
Identities = 31/80 (38%), Positives = 45/80 (56%), Gaps = 2/80 (2%)
Query: 270 STQPNGGLSHTG--TPKPSGVQMDQPCCRALYDFEPENEGELGFKEGDIITLTNQIDENW 327
S +GG S+ G TP P Q+ C+ALY F+ + EL ++GDI+ + + +E W
Sbjct: 416 SKASSGGQSNPGSSTPAPGAAQLSSRLCKALYSFQARQDDELNLEKGDIVIIHEKKEEGW 475
Query: 328 YEGMLHGHSGFFPINYVEIL 347
+ G L+G G FP YVE L
Sbjct: 476 WFGSLNGKKGHFPAAYVEEL 495
>gi|16418431 nitric oxide synthase trafficker isoform 1 [Homo
sapiens]
Length = 428
Score = 64.7 bits (156), Expect = 1e-10
Identities = 31/80 (38%), Positives = 45/80 (56%), Gaps = 2/80 (2%)
Query: 270 STQPNGGLSHTG--TPKPSGVQMDQPCCRALYDFEPENEGELGFKEGDIITLTNQIDENW 327
S +GG S+ G TP P Q+ C+ALY F+ + EL ++GDI+ + + +E W
Sbjct: 338 SKASSGGQSNPGSSTPAPGAAQLSSRLCKALYSFQARQDDELNLEKGDIVIIHEKKEEGW 397
Query: 328 YEGMLHGHSGFFPINYVEIL 347
+ G L+G G FP YVE L
Sbjct: 398 WFGSLNGKKGHFPAAYVEEL 417
>gi|67514036 SH3-domain kinase binding protein 1 isoform b [Homo
sapiens]
Length = 628
Score = 64.7 bits (156), Expect = 1e-10
Identities = 32/75 (42%), Positives = 47/75 (62%), Gaps = 7/75 (9%)
Query: 280 TGTPKPSGVQMD-----QPCCRALYDFEPENEGELGFKEGDIITLTNQ--IDENWYEGML 332
T TP S +MD + C+ ++ +E +N+ EL KEGDI+TL N+ ID W+EG L
Sbjct: 215 TATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGEL 274
Query: 333 HGHSGFFPINYVEIL 347
+G G FP N+V++L
Sbjct: 275 NGRRGVFPDNFVKLL 289
Score = 57.4 bits (137), Expect = 2e-08
Identities = 21/53 (39%), Positives = 37/53 (69%)
Query: 295 CRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVEIL 347
C+ + + P+N+ EL K GDII + +++E W+EG+L+G +G FP N+++ L
Sbjct: 66 CQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKEL 118
>gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo
sapiens]
Length = 665
Score = 64.7 bits (156), Expect = 1e-10
Identities = 32/75 (42%), Positives = 47/75 (62%), Gaps = 7/75 (9%)
Query: 280 TGTPKPSGVQMD-----QPCCRALYDFEPENEGELGFKEGDIITLTNQ--IDENWYEGML 332
T TP S +MD + C+ ++ +E +N+ EL KEGDI+TL N+ ID W+EG L
Sbjct: 252 TATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGEL 311
Query: 333 HGHSGFFPINYVEIL 347
+G G FP N+V++L
Sbjct: 312 NGRRGVFPDNFVKLL 326
Score = 57.4 bits (137), Expect = 2e-08
Identities = 21/53 (39%), Positives = 37/53 (69%)
Query: 295 CRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVEIL 347
C+ + + P+N+ EL K GDII + +++E W+EG+L+G +G FP N+++ L
Sbjct: 103 CQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKEL 155
Score = 43.9 bits (102), Expect = 2e-04
Identities = 17/46 (36%), Positives = 29/46 (63%)
Query: 299 YDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYV 344
+D++ +++ EL G+IIT + D W+EG ++G G FP N+V
Sbjct: 8 FDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFV 53
>gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo
sapiens]
Length = 1100
Score = 64.7 bits (156), Expect = 1e-10
Identities = 27/52 (51%), Positives = 37/52 (71%)
Query: 296 RALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVEIL 347
+A+YDF+ + EL FK+GD + + +ID+NWYEG HG G FPI+YVE L
Sbjct: 869 KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL 920
Score = 51.6 bits (122), Expect = 1e-06
Identities = 21/53 (39%), Positives = 34/53 (64%), Gaps = 2/53 (3%)
Query: 297 ALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHG--HSGFFPINYVEIL 347
A Y+F + EL ++GD + L ++D+NWYEG + G G FP++YVE++
Sbjct: 945 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 997
Score = 43.1 bits (100), Expect = 4e-04
Identities = 21/54 (38%), Positives = 31/54 (57%), Gaps = 2/54 (3%)
Query: 296 RALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHS--GFFPINYVEIL 347
+ALY++ P NE EL +E D+I + + D+ W+ G G FP NYV+ L
Sbjct: 1047 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1100
>gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo
sapiens]
Length = 666
Score = 64.7 bits (156), Expect = 1e-10
Identities = 27/52 (51%), Positives = 37/52 (71%)
Query: 296 RALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVEIL 347
+A+YDF+ + EL FK+GD + + +ID+NWYEG HG G FPI+YVE L
Sbjct: 435 KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL 486
Score = 51.6 bits (122), Expect = 1e-06
Identities = 21/53 (39%), Positives = 34/53 (64%), Gaps = 2/53 (3%)
Query: 297 ALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHG--HSGFFPINYVEIL 347
A Y+F + EL ++GD + L ++D+NWYEG + G G FP++YVE++
Sbjct: 511 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 563
Score = 43.1 bits (100), Expect = 4e-04
Identities = 21/54 (38%), Positives = 31/54 (57%), Gaps = 2/54 (3%)
Query: 296 RALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHS--GFFPINYVEIL 347
+ALY++ P NE EL +E D+I + + D+ W+ G G FP NYV+ L
Sbjct: 613 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 666
>gi|222446607 SH3 domain containing ring finger 2 [Homo sapiens]
Length = 729
Score = 64.3 bits (155), Expect = 2e-10
Identities = 42/117 (35%), Positives = 63/117 (53%), Gaps = 3/117 (2%)
Query: 238 VRLEERIRQASSQPRREYQPKP-RMSLEFPTGDSTQPNGGLSHTGTPKPS-GVQMDQ-PC 294
VRL + +R S R +P M+L+ T P + P+ + MD P
Sbjct: 70 VRLLDGVRSGQSSGRGGSFRRPGTMTLQDGRKSRTNPRRLQASPFRLVPNVRIHMDGVPR 129
Query: 295 CRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVEILVALP 351
+AL ++ +N G+L F +GDII L Q+DENWY+G ++G SG FP + VE++ LP
Sbjct: 130 AKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGISGNFPASSVEVIKQLP 186
Score = 54.7 bits (130), Expect = 1e-07
Identities = 28/59 (47%), Positives = 37/59 (62%), Gaps = 6/59 (10%)
Query: 293 PCCRALYDFE------PENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVE 345
P CRALY+F+ EN+ L F + DIIT+ +++DENW EG L G FPI +VE
Sbjct: 190 PLCRALYNFDLRGKDKSENQDCLTFLKDDIITVISRVDENWAEGKLGDKVGIFPILFVE 248
>gi|167234422 hematopoietic cell-specific Lyn substrate 1 [Homo
sapiens]
Length = 486
Score = 60.8 bits (146), Expect = 2e-09
Identities = 25/51 (49%), Positives = 32/51 (62%)
Query: 297 ALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVEIL 347
ALYD++ E EL F D+IT +DE W+ G HGH G FP NYV++L
Sbjct: 435 ALYDYQGEGSDELSFDPDDVITDIEMVDEGWWRGRCHGHFGLFPANYVKLL 485
>gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo
sapiens]
Length = 671
Score = 60.5 bits (145), Expect = 2e-09
Identities = 31/83 (37%), Positives = 47/83 (56%), Gaps = 5/83 (6%)
Query: 267 TGDSTQPNGGLSHTGTPKPSGVQMDQPCCRALYDFEPENEGELGFKEGDIITLTNQIDEN 326
T D + NGG G+P + + R +DF+ ++ EL ++GDI+ + ++D+N
Sbjct: 362 TRDPSASNGG----GSPARRE-EKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKN 416
Query: 327 WYEGMLHGHSGFFPINYVEILVA 349
W EG HG G FP NYVE+L A
Sbjct: 417 WLEGEHHGRLGIFPANYVEVLPA 439
Score = 53.5 bits (127), Expect = 3e-07
Identities = 31/94 (32%), Positives = 47/94 (50%), Gaps = 5/94 (5%)
Query: 256 QPKPRMSLEFPTGDSTQPNGGLSHT---GTPKPSGVQMDQPCCRALYDFEPENEGELGFK 312
+P+P+ G + + G SH GT P+ Q+ RA+Y + P+NE EL +
Sbjct: 575 EPRPQTQNLGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELR 634
Query: 313 EGDIITLTNQIDENWYEGMLHGHS--GFFPINYV 344
EGD + + Q D+ W+ G+ G FP NYV
Sbjct: 635 EGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYV 668
Score = 48.9 bits (115), Expect = 7e-06
Identities = 22/52 (42%), Positives = 34/52 (65%), Gaps = 2/52 (3%)
Query: 297 ALYDFEPENEGELGFKEGDIITLTNQIDENWYEGML--HGHSGFFPINYVEI 346
A Y F+ + E EL F++G+ I L +++ENWYEG + G G FP +YV++
Sbjct: 461 AQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQV 512
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.133 0.376
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,182,280
Number of Sequences: 37866
Number of extensions: 638387
Number of successful extensions: 2780
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 206
Number of HSP's successfully gapped in prelim test: 258
Number of HSP's that attempted gapping in prelim test: 2230
Number of HSP's gapped (non-prelim): 738
length of query: 352
length of database: 18,247,518
effective HSP length: 103
effective length of query: 249
effective length of database: 14,347,320
effective search space: 3572482680
effective search space used: 3572482680
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.