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Search of human proteins with 4506885
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4506885 semenogelin II precursor [Homo sapiens]
(582 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4506885 semenogelin II precursor [Homo sapiens] 1177 0.0
gi|4506883 semenogelin I isoform a preproprotein [Homo sapiens] 647 0.0
gi|38049014 semenogelin I isoform b preproprotein [Homo sapiens] 578 e-165
gi|60097902 filaggrin [Homo sapiens] 69 2e-11
gi|62122917 filaggrin family member 2 [Homo sapiens] 62 1e-09
gi|42560244 peptidylprolyl isomerase G [Homo sapiens] 56 1e-07
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 53 7e-07
gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens] 51 3e-06
gi|212549782 caspase 8 associated protein 2 [Homo sapiens] 50 4e-06
gi|6912288 caspase 8 associated protein 2 [Homo sapiens] 50 4e-06
gi|212549532 caspase 8 associated protein 2 [Homo sapiens] 50 4e-06
gi|57864582 hornerin [Homo sapiens] 50 6e-06
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens] 50 7e-06
gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens] 50 7e-06
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 49 1e-05
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 47 5e-05
gi|224548936 hypothetical protein LOC100170229 [Homo sapiens] 47 6e-05
gi|4504487 histidine rich calcium binding protein precursor [Hom... 47 6e-05
gi|4557509 cylicin 2 [Homo sapiens] 46 8e-05
gi|171916097 repetin [Homo sapiens] 46 8e-05
gi|55749769 CWC22 spliceosome-associated protein homolog [Homo s... 44 3e-04
gi|87299628 biorientation of chromosomes in cell division 1-like... 44 4e-04
gi|36031016 CTCL tumor antigen L14-2 [Homo sapiens] 44 4e-04
gi|153251865 hypothetical protein LOC84226 [Homo sapiens] 44 5e-04
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens] 43 0.001
gi|238624188 diffuse panbronchiolitis critical region 1 protein ... 42 0.001
gi|153792012 DNA polymerase zeta [Homo sapiens] 42 0.001
gi|38044112 restin isoform b [Homo sapiens] 42 0.002
gi|4506751 restin isoform a [Homo sapiens] 42 0.002
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 42 0.002
>gi|4506885 semenogelin II precursor [Homo sapiens]
Length = 582
Score = 1177 bits (3045), Expect = 0.0
Identities = 582/582 (100%), Positives = 582/582 (100%)
Query: 1 MKSIILFVLSLLLILEKQAAVMGQKGGSKGQLPSGSSQFPHGQKGQHYFGQKDQQHTKSK 60
MKSIILFVLSLLLILEKQAAVMGQKGGSKGQLPSGSSQFPHGQKGQHYFGQKDQQHTKSK
Sbjct: 1 MKSIILFVLSLLLILEKQAAVMGQKGGSKGQLPSGSSQFPHGQKGQHYFGQKDQQHTKSK 60
Query: 61 GSFSIQHTYHVDINDHDWTRKSQQYDLNALHKATKSKQHLGGSQQLLNYKQEGRDHDKSK 120
GSFSIQHTYHVDINDHDWTRKSQQYDLNALHKATKSKQHLGGSQQLLNYKQEGRDHDKSK
Sbjct: 61 GSFSIQHTYHVDINDHDWTRKSQQYDLNALHKATKSKQHLGGSQQLLNYKQEGRDHDKSK 120
Query: 121 GHFHMIVIHHKGGQAHHGTQNPSQDQGNSPSGKGLSSQCSNTEKRLWVHGLSKEQASASG 180
GHFHMIVIHHKGGQAHHGTQNPSQDQGNSPSGKGLSSQCSNTEKRLWVHGLSKEQASASG
Sbjct: 121 GHFHMIVIHHKGGQAHHGTQNPSQDQGNSPSGKGLSSQCSNTEKRLWVHGLSKEQASASG 180
Query: 181 AQKGRTQGGSQSSYVLQTEELVVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHP 240
AQKGRTQGGSQSSYVLQTEELVVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHP
Sbjct: 181 AQKGRTQGGSQSSYVLQTEELVVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHP 240
Query: 241 AHQDRLQHGPKDIFTTQDELLVYNKNQHQTKNLSQDQEHGRKAHKISYPSSRTEERQLHH 300
AHQDRLQHGPKDIFTTQDELLVYNKNQHQTKNLSQDQEHGRKAHKISYPSSRTEERQLHH
Sbjct: 241 AHQDRLQHGPKDIFTTQDELLVYNKNQHQTKNLSQDQEHGRKAHKISYPSSRTEERQLHH 300
Query: 301 GEKSVQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSSTEERHLNC 360
GEKSVQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSSTEERHLNC
Sbjct: 301 GEKSVQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSSTEERHLNC 360
Query: 361 GEKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEERRLNS 420
GEKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEERRLNS
Sbjct: 361 GEKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEERRLNS 420
Query: 421 GEKDVQKGVSKGSISIQTEEKIHGKSQNQVTIPSQDQEHGHKENKMSYQSSSTEERRLNY 480
GEKDVQKGVSKGSISIQTEEKIHGKSQNQVTIPSQDQEHGHKENKMSYQSSSTEERRLNY
Sbjct: 421 GEKDVQKGVSKGSISIQTEEKIHGKSQNQVTIPSQDQEHGHKENKMSYQSSSTEERRLNY 480
Query: 481 GGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQNAKGKSGQSADSKQDLLSH 540
GGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQNAKGKSGQSADSKQDLLSH
Sbjct: 481 GGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQNAKGKSGQSADSKQDLLSH 540
Query: 541 EQKGRYKQESSESHNIVITEHEVAQDDHLTQQYNEDRNPIST 582
EQKGRYKQESSESHNIVITEHEVAQDDHLTQQYNEDRNPIST
Sbjct: 541 EQKGRYKQESSESHNIVITEHEVAQDDHLTQQYNEDRNPIST 582
>gi|4506883 semenogelin I isoform a preproprotein [Homo sapiens]
Length = 462
Score = 647 bits (1670), Expect = 0.0
Identities = 327/436 (75%), Positives = 365/436 (83%)
Query: 1 MKSIILFVLSLLLILEKQAAVMGQKGGSKGQLPSGSSQFPHGQKGQHYFGQKDQQHTKSK 60
MK I+FVLSLLLILEKQAAVMGQKGGSKG+LPS SQFPHGQKGQHY GQK +Q T+SK
Sbjct: 1 MKPNIIFVLSLLLILEKQAAVMGQKGGSKGRLPSEFSQFPHGQKGQHYSGQKGKQQTESK 60
Query: 61 GSFSIQHTYHVDINDHDWTRKSQQYDLNALHKATKSKQHLGGSQQLLNYKQEGRDHDKSK 120
GSFSIQ+TYHVD NDHD +RKSQQYDLNALHK TKS++HLGGSQQLL+ KQEGRDHDKSK
Sbjct: 61 GSFSIQYTYHVDANDHDQSRKSQQYDLNALHKTTKSQRHLGGSQQLLHNKQEGRDHDKSK 120
Query: 121 GHFHMIVIHHKGGQAHHGTQNPSQDQGNSPSGKGLSSQCSNTEKRLWVHGLSKEQASASG 180
GHFH +VIHHKGG+AH GTQNPSQDQGNSPSGKG+SSQ SNTE+RLWVHGLSKEQ S SG
Sbjct: 121 GHFHRVVIHHKGGKAHRGTQNPSQDQGNSPSGKGISSQYSNTEERLWVHGLSKEQTSVSG 180
Query: 181 AQKGRTQGGSQSSYVLQTEELVVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHP 240
AQKGR QGGSQSSYVLQTEELV NKQQRETKNSHQNKGHYQNVV+VREEHSSK+QTSL P
Sbjct: 181 AQKGRKQGGSQSSYVLQTEELVANKQQRETKNSHQNKGHYQNVVEVREEHSSKVQTSLCP 240
Query: 241 AHQDRLQHGPKDIFTTQDELLVYNKNQHQTKNLSQDQEHGRKAHKISYPSSRTEERQLHH 300
AHQD+LQHG KDIF+TQDELLVYNKNQHQTKNL+QDQ+HGRKA+KISY SS TEER+LH+
Sbjct: 241 AHQDKLQHGSKDIFSTQDELLVYNKNQHQTKNLNQDQQHGRKANKISYQSSSTEERRLHY 300
Query: 301 GEKSVQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSSTEERHLNC 360
GE VQKDVS+ SI QTEEK GKSQ Q+TI SQ+QEH K NKISYQSSSTEER L+
Sbjct: 301 GENGVQKDVSQSSIYSQTEEKAQGKSQKQITIPSQEQEHSQKANKISYQSSSTEERRLHY 360
Query: 361 GEKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEERRLNS 420
GE G+QK VS+ SI QTE+ + GKSQ Q P Q +G S QS++ E+ L+
Sbjct: 361 GENGVQKDVSQRSIYSQTEKLVAGKSQIQAPNPKQEPWHGENAKGESGQSTNREQDLLSH 420
Query: 421 GEKDVQKGVSKGSISI 436
+K + S G + I
Sbjct: 421 EQKGRHQHGSHGGLDI 436
Score = 288 bits (738), Expect = 7e-78
Identities = 189/447 (42%), Positives = 244/447 (54%), Gaps = 26/447 (5%)
Query: 153 KGLSSQCSNTEKRLWVHGLSKEQASASGAQKGRTQGGSQSSYVLQTEELVVNKQQRETKN 212
KG S +E + HG + S QKG+ Q S+ S+ +Q V +++
Sbjct: 25 KGGSKGRLPSEFSQFPHGQKGQHYSG---QKGKQQTESKGSFSIQYTYHVDANDHDQSRK 81
Query: 213 SHQNKGHYQNVVDVREEHSSKLQTSLHPAHQDRLQHGPKDIFTTQDELLVYNKN---QHQ 269
S Q + + + H Q LH + R K F +++++K
Sbjct: 82 SQQYDLNALHKTTKSQRHLGGSQQLLHNKQEGRDHDKSKGHF---HRVVIHHKGGKAHRG 138
Query: 270 TKNLSQDQEHGRKAHKISYPSSRTEERQLHHGEKSVQKDVS-----------KGSISIQT 318
T+N SQDQ + IS S TEER HG Q VS + S +QT
Sbjct: 139 TQNPSQDQGNSPSGKGISSQYSNTEERLWVHGLSKEQTSVSGAQKGRKQGGSQSSYVLQT 198
Query: 319 EEKIHGKSQNQVTIHSQDQEHGHKENKISYQ---SSSTEERHLNCGEKGIQKGVSKGSIS 375
EE + K Q + + Q GH +N + + SS + + +Q G SK S
Sbjct: 199 EELVANKQQRETK--NSHQNKGHYQNVVEVREEHSSKVQTSLCPAHQDKLQHG-SKDIFS 255
Query: 376 IQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEERRLNSGEKDVQKGVSKGSIS 435
Q E ++ K+Q+Q + +Q Q++G K NKISYQSSSTEERRL+ GE VQK VS+ SI
Sbjct: 256 TQDELLVYNKNQHQTKNLNQDQQHGRKANKISYQSSSTEERRLHYGENGVQKDVSQSSIY 315
Query: 436 IQTEEKIHGKSQNQVTIPSQDQEHGHKENKMSYQSSSTEERRLNYGGKSTQKDVSQSSIS 495
QTEEK GKSQ Q+TIPSQ+QEH K NK+SYQSSSTEERRL+YG QKDVSQ SI
Sbjct: 316 SQTEEKAQGKSQKQITIPSQEQEHSQKANKISYQSSSTEERRLHYGENGVQKDVSQRSIY 375
Query: 496 FQIEKLVEGKSQIQTPNPNQDQWSGQNAKGKSGQSADSKQDLLSHEQKGRYKQESSESHN 555
Q EKLV GKSQIQ PNP Q+ W G+NAKG+SGQS + +QDLLSHEQKGR++ S +
Sbjct: 376 SQTEKLVAGKSQIQAPNPKQEPWHGENAKGESGQSTNREQDLLSHEQKGRHQHGSHGGLD 435
Query: 556 IVITEHEVAQDDHLTQQYNEDRNPIST 582
IVI E E D HL Q N DRNP+ T
Sbjct: 436 IVIIEQEDDSDRHLAQHLNNDRNPLFT 462
>gi|38049014 semenogelin I isoform b preproprotein [Homo sapiens]
Length = 402
Score = 578 bits (1490), Expect = e-165
Identities = 291/381 (76%), Positives = 322/381 (84%)
Query: 1 MKSIILFVLSLLLILEKQAAVMGQKGGSKGQLPSGSSQFPHGQKGQHYFGQKDQQHTKSK 60
MK I+FVLSLLLILEKQAAVMGQKGGSKG+LPS SQFPHGQKGQHY GQK +Q T+SK
Sbjct: 1 MKPNIIFVLSLLLILEKQAAVMGQKGGSKGRLPSEFSQFPHGQKGQHYSGQKGKQQTESK 60
Query: 61 GSFSIQHTYHVDINDHDWTRKSQQYDLNALHKATKSKQHLGGSQQLLNYKQEGRDHDKSK 120
GSFSIQ+TYHVD NDHD +RKSQQYDLNALHK TKS++HLGGSQQLL+ KQEGRDHDKSK
Sbjct: 61 GSFSIQYTYHVDANDHDQSRKSQQYDLNALHKTTKSQRHLGGSQQLLHNKQEGRDHDKSK 120
Query: 121 GHFHMIVIHHKGGQAHHGTQNPSQDQGNSPSGKGLSSQCSNTEKRLWVHGLSKEQASASG 180
GHFH +VIHHKGG+AH GTQNPSQDQGNSPSGKG+SSQ SNTE+RLWVHGLSKEQ S SG
Sbjct: 121 GHFHRVVIHHKGGKAHRGTQNPSQDQGNSPSGKGISSQYSNTEERLWVHGLSKEQTSVSG 180
Query: 181 AQKGRTQGGSQSSYVLQTEELVVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHP 240
AQKGR QGGSQSSYVLQTEELV NKQQRETKNSHQNKGHYQNVV+VREEHSSK+QTSL P
Sbjct: 181 AQKGRKQGGSQSSYVLQTEELVANKQQRETKNSHQNKGHYQNVVEVREEHSSKVQTSLCP 240
Query: 241 AHQDRLQHGPKDIFTTQDELLVYNKNQHQTKNLSQDQEHGRKAHKISYPSSRTEERQLHH 300
AHQD+LQHG KDIF+TQDELLVYNKNQHQTKNL+QDQ+HGRKA+KISY SS TEER+LH+
Sbjct: 241 AHQDKLQHGSKDIFSTQDELLVYNKNQHQTKNLNQDQQHGRKANKISYQSSSTEERRLHY 300
Query: 301 GEKSVQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSSTEERHLNC 360
GE VQKDVS+ SI QTEEK GKSQ Q Q+ HG S QS++ E+ L+
Sbjct: 301 GENGVQKDVSQSSIYSQTEEKAQGKSQIQAPNPKQEPWHGENAKGESGQSTNREQDLLSH 360
Query: 361 GEKGIQKGVSKGSISIQTEEQ 381
+KG + S G + I EQ
Sbjct: 361 EQKGRHQHGSHGGLDIVIIEQ 381
Score = 210 bits (535), Expect = 3e-54
Identities = 127/301 (42%), Positives = 172/301 (57%), Gaps = 15/301 (4%)
Query: 295 ERQLHHGEKSVQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSSTE 354
++ LH+ ++ D SKG GK+ SQDQ + IS Q S+TE
Sbjct: 104 QQLLHNKQEGRDHDKSKGHFHRVVIHHKGGKAHRGTQNPSQDQGNSPSGKGISSQYSNTE 163
Query: 355 ER-----------HLNCGEKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKE 403
ER ++ +KG ++G S+ S +QTEE + K Q + + + Q GH +
Sbjct: 164 ERLWVHGLSKEQTSVSGAQKGRKQGGSQSSYVLQTEELVANKQQRETK--NSHQNKGHYQ 221
Query: 404 N--KISYQSSSTEERRLNSGEKDVQKGVSKGSISIQTEEKIHGKSQNQVTIPSQDQEHGH 461
N ++ + SS + L +D + SK S Q E ++ K+Q+Q +QDQ+HG
Sbjct: 222 NVVEVREEHSSKVQTSLCPAHQDKLQHGSKDIFSTQDELLVYNKNQHQTKNLNQDQQHGR 281
Query: 462 KENKMSYQSSSTEERRLNYGGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQ 521
K NK+SYQSSSTEERRL+YG QKDVSQSSI Q E+ +GKSQIQ PNP Q+ W G+
Sbjct: 282 KANKISYQSSSTEERRLHYGENGVQKDVSQSSIYSQTEEKAQGKSQIQAPNPKQEPWHGE 341
Query: 522 NAKGKSGQSADSKQDLLSHEQKGRYKQESSESHNIVITEHEVAQDDHLTQQYNEDRNPIS 581
NAKG+SGQS + +QDLLSHEQKGR++ S +IVI E E D HL Q N DRNP+
Sbjct: 342 NAKGESGQSTNREQDLLSHEQKGRHQHGSHGGLDIVIIEQEDDSDRHLAQHLNNDRNPLF 401
Query: 582 T 582
T
Sbjct: 402 T 402
Score = 138 bits (348), Expect = 1e-32
Identities = 118/382 (30%), Positives = 173/382 (45%), Gaps = 26/382 (6%)
Query: 153 KGLSSQCSNTEKRLWVHGLSKEQASASGAQKGRTQGGSQSSYVLQTEELVVNKQQRETKN 212
KG S +E + HG + S QKG+ Q S+ S+ +Q V +++
Sbjct: 25 KGGSKGRLPSEFSQFPHGQKGQHYSG---QKGKQQTESKGSFSIQYTYHVDANDHDQSRK 81
Query: 213 SHQNKGHYQNVVDVREEHSSKLQTSLHPAHQDRLQHGPKDIFTTQDELLVYNKN---QHQ 269
S Q + + + H Q LH + R K F +++++K
Sbjct: 82 SQQYDLNALHKTTKSQRHLGGSQQLLHNKQEGRDHDKSKGHF---HRVVIHHKGGKAHRG 138
Query: 270 TKNLSQDQEHGRKAHKISYPSSRTEERQLHHGEKSVQKDVS-----------KGSISIQT 318
T+N SQDQ + IS S TEER HG Q VS + S +QT
Sbjct: 139 TQNPSQDQGNSPSGKGISSQYSNTEERLWVHGLSKEQTSVSGAQKGRKQGGSQSSYVLQT 198
Query: 319 EEKIHGKSQNQVTIHSQDQEHGHKENKISYQ---SSSTEERHLNCGEKGIQKGVSKGSIS 375
EE + K Q + + Q GH +N + + SS + + +Q G SK S
Sbjct: 199 EELVANKQQRETK--NSHQNKGHYQNVVEVREEHSSKVQTSLCPAHQDKLQHG-SKDIFS 255
Query: 376 IQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEERRLNSGEKDVQKGVSKGSIS 435
Q E ++ K+Q+Q + +Q Q++G K NKISYQSSSTEERRL+ GE VQK VS+ SI
Sbjct: 256 TQDELLVYNKNQHQTKNLNQDQQHGRKANKISYQSSSTEERRLHYGENGVQKDVSQSSIY 315
Query: 436 IQTEEKIHGKSQNQVTIPSQDQEHGHKENKMSYQSSSTEERRLNYGGKSTQKDVSQSSIS 495
QTEEK GKSQ Q P Q+ HG S QS++ E+ L++ K + S +
Sbjct: 316 SQTEEKAQGKSQIQAPNPKQEPWHGENAKGESGQSTNREQDLLSHEQKGRHQHGSHGGLD 375
Query: 496 FQIEKLVEGKSQIQTPNPNQDQ 517
I + + + + N D+
Sbjct: 376 IVIIEQEDDSDRHLAQHLNNDR 397
>gi|60097902 filaggrin [Homo sapiens]
Length = 4061
Score = 68.6 bits (166), Expect = 2e-11
Identities = 122/610 (20%), Positives = 216/610 (35%), Gaps = 108/610 (17%)
Query: 26 GGSKGQLPSGSSQFPHGQKGQHYFGQKDQQHTKSKGSFSIQHTYHVDINDHDWTRKSQQY 85
G + S + H Q GQ GQ + T S D + + S+++
Sbjct: 2531 GSRHHEASSRADSSGHSQVGQ---GQSEGPRTSRNWGSSFSQ----DSDSQGHSEDSERW 2583
Query: 86 DLNALHKATKSKQHLGGSQ-QLLNYKQEGRDHDKSK-GHFHMIVIHHKGGQAHHGTQNPS 143
+A S+ H G +Q QL + + R H + + GH H + G H T +
Sbjct: 2584 SGSA------SRNHHGSAQEQLRDGSRHPRSHQEDRAGHGHSADSSRQSGTRHTQTSSGG 2637
Query: 144 Q-----DQGNSPSGKGLSSQCSNTEKRLWVHGLSKEQASA----------SGAQKGRTQG 188
Q +Q S +G+ S + G+ QAS+ SG+Q +G
Sbjct: 2638 QAASSHEQARSSAGERHGSHHQQSADSSRHSGIGHGQASSAVRDSGHRGYSGSQASDNEG 2697
Query: 189 GSQSSYVLQTEELVVNKQQRETKNSHQ------------NKGHYQNVVDVREEHSSK--- 233
S+ S T+ + + Q + SHQ + G + V E+ S
Sbjct: 2698 HSEDS---DTQSVSAHGQAGSHQQSHQESARGRSGETSGHSGSFLYQVSTHEQSESSHGW 2754
Query: 234 -------LQTSLHPAHQDRLQHGPKDIFTTQDELLVY----------------------- 263
Q S H QD +H QD + +
Sbjct: 2755 TGPSTRGRQGSRHEQAQDSSRHSASQ--DGQDTIRGHPGSSRGGRQGYHHEHSVDSSGHS 2812
Query: 264 -NKNQHQTKNLSQDQEHGRKAHKISYPSSRTEERQ--------LHHGEKSVQKDVSKGSI 314
+ + H T D G+ + + ++R EE+ H E S D+S+ S
Sbjct: 2813 GSHHSHTTSQGRSDASRGQSGSRSASRTTRNEEQSGDGSRHSGSRHHEASTHADISRHSQ 2872
Query: 315 SIQTEEKIHGKSQNQVTIHSQDQE-HGHKENKISYQSSSTEERHLNCGEKGIQKGVSKGS 373
++Q + + +S+ Q + SQD + GH E+ + S++ H + E+ ++ G S+
Sbjct: 2873 AVQGQSEGSRRSRRQGSSVSQDSDSEGHSEDSERWSGSASRNHHGSAQEQ-LRDG-SRHP 2930
Query: 374 ISIQTEEQIHGKSQNQVRIP----SQAQEYGHKENKISYQSSSTEER----RLNSGEKDV 425
S Q + HG S + R +Q G + SS ER S +
Sbjct: 2931 RSHQEDRAGHGHSADSSRQSGTRHTQTSSGGQAASSHEQARSSAGERHGSHHQQSADSSR 2990
Query: 426 QKGVSKGSISIQTEEKIH-GKSQNQVTIPSQDQEHGHKENKMSYQSSSTEERRLNYGGKS 484
G+ G S + H G S +Q + E ++ ++ + + ++ +
Sbjct: 2991 HSGIGHGQASSAVRDSGHRGYSGSQASDNEGHSEDSDTQSVSAHGQAGSHQQSHQESARG 3050
Query: 485 TQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQNAKGKSGQSADSKQDLLSHEQKG 544
+ S S SF + +S+ + W+G + +G+ G + QD H
Sbjct: 3051 RSGETSGHSGSFLYQVSTHEQSE------SSHGWTGPSTRGRQGSRHEQAQDSSRH-SAS 3103
Query: 545 RYKQESSESH 554
+Y Q++ H
Sbjct: 3104 QYGQDTIRGH 3113
Score = 65.1 bits (157), Expect = 2e-10
Identities = 126/557 (22%), Positives = 208/557 (37%), Gaps = 47/557 (8%)
Query: 16 EKQAAVMGQKGGSKGQLPS---GSSQFPHGQKGQHYFGQKDQQHTKSKGSFSIQHTYHVD 72
E+Q+ + GS+ PS GSS+ H Q GQ G+ T + S+ +
Sbjct: 1547 EEQSGDGSRHSGSRHHEPSTRAGSSR--HSQVGQ---GESAGSKTSRRQGSSVSQDRDSE 1601
Query: 73 INDHDWTRKSQQYDLNALHKATKSKQHLGGSQQLLNYKQEGRDHDKSKGHFHMIVIHH-- 130
+ D R+S+ N A + +H GS+ +++++ H S H
Sbjct: 1602 GHSEDSERRSESASRNHYGSAREQSRH--GSRNPRSHQEDRASHGHSAESSRQSGTRHAE 1659
Query: 131 --KGGQA----HHGTQNPSQDQGNSPSGKGLSSQCSNTEKRL--WVHGLSKEQASASGAQ 182
GGQA +P + G+ SS S T +R V G S + S SG+Q
Sbjct: 1660 TSSGGQAASSQEQARSSPGERHGSRHQQSADSSTDSGTGRRQDSSVVGDSGNRGS-SGSQ 1718
Query: 183 KGRTQGGSQSSYVLQTEELVVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHPAH 242
++G S+ S T+ + + Q + SHQ Q+ S Q S H
Sbjct: 1719 ASDSEGHSEES---DTQSVSAHGQAGPHQQSHQESTRGQSGERSGRSGSFLYQVSTH--E 1773
Query: 243 QDRLQHGPKDIFTTQDELLVYNKNQHQTKN-LSQDQEHGRKAHKISYPSSRTEERQLHHG 301
Q HG T + + + + +++ SQ+ + + H P S RQ H
Sbjct: 1774 QSESAHGRTGPSTGGRQRSRHEQARDSSRHSASQEGQDTIRGH----PGSSRGGRQGSHY 1829
Query: 302 EKSVQKDVSKGSISIQT---EEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSSTEERHL 358
E+SV GS T E + Q+ S+ + + S S S
Sbjct: 1830 EQSVDSSGHSGSHHSHTTSQERSDVSRGQSGSRSVSRQTRNEKQSGDGSRHSGSRHHEAS 1889
Query: 359 NCGEKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEERRL 418
+ + V +G S + G S +Q + GH E+ + S S L
Sbjct: 1890 SRADSSRHSQVGQGQSSGPRTSRNQGSSVSQ-----DSDSQGHSEDSERW-SGSASRNHL 1943
Query: 419 NSGEKDVQKGVSKGSISIQTEEKIHGKSQNQVTIPSQDQEHGHKENKMSYQSSSTEER-R 477
S + + G S+ S + HG S + S+ H E+ Q++S+ E+ R
Sbjct: 1944 GSAWEQSRDG-SRHPGSHHEDRAGHGHSADS----SRQSGTRHTESSSRGQAASSHEQAR 1998
Query: 478 LNYGGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQNAKGKSGQSADSKQDL 537
+ G + QS+ S + + G++ + +SG A G S DS
Sbjct: 1999 SSAGERHGSHHQLQSADSSRHSGIGHGQASSAVRDSGHRGYSGSQASDSEGHSEDSDTQS 2058
Query: 538 LSHEQK-GRYKQESSES 553
+S + K G ++Q ES
Sbjct: 2059 VSAQGKAGPHQQSHKES 2075
Score = 64.7 bits (156), Expect = 2e-10
Identities = 141/623 (22%), Positives = 221/623 (35%), Gaps = 104/623 (16%)
Query: 23 GQKGGSKGQLPSGSSQFPHGQKGQHYFGQKDQQHTKSK--GSFSIQHTYHVDI-NDHDWT 79
G S Q SG Q H Q+ H +D+ +S+ GSF Q + H + H WT
Sbjct: 752 GHSEDSDTQSVSGHGQAGHHQQS-HQESARDRSGERSRRSGSFLYQVSTHKQSESSHGWT 810
Query: 80 RKS---------QQYDLNALHKATKSKQ-----HLGGSQQLLNYKQEGRDHDKSKGHFHM 125
S +Q N+ H A++ Q H G S++ ++G H++S
Sbjct: 811 GPSTGVRQGSHHEQARDNSRHSASQDGQDTIRGHPGSSRR----GRQGSHHEQSVDRSG- 865
Query: 126 IVIHHKGGQAHHGTQNPSQDQGNSPSGKGLSSQCSNTEKR--------------LWVHG- 170
H G H T D SG +S+ + E++ H
Sbjct: 866 ----HSGSHHSHTTSQGRSDASRGQSGSRSASRTTRNEEQSRDGSRHSGSRHHEASSHAD 921
Query: 171 LSKEQASASGAQKGRTQGGSQSSYVLQTEELVVNKQQRETKNSHQNKGHYQNVVDVREEH 230
+S+ + G +G Q S V Q + + + E + ++ H + + + H
Sbjct: 922 ISRHSQAGQGQSEGSRTSRRQGSSVSQDSDSEGHSEDSERWSGSASRNHRGSAQE-QSRH 980
Query: 231 SSKLQTSLHPA--HQDRLQHG-----PKDIFTTQDELLVYNK--NQHQTKNLSQDQEHGR 281
S+ HP H+DR HG + T E + + H+ S + HG
Sbjct: 981 GSR-----HPRSHHEDRAGHGHSADSSRQSGTPHAETSSGGQAASSHEQARSSPGERHGS 1035
Query: 282 KAHKISYPSSRTE---ERQLHHGEKSVQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQE 338
+ H+ S SSR RQ + S GS + +E V+ H QD
Sbjct: 1036 R-HQQSADSSRHSGIPRRQASSAVRDSGHWGSSGSQASDSEGHSEESDTQSVSGHGQDGP 1094
Query: 339 H--GHKEN-------------KISYQSSSTEERHLNCGEKGIQKGVSKGSISIQTEEQI- 382
H H+E+ YQ S+ E+ G G +GS Q +
Sbjct: 1095 HQQSHQESARDWSGGRSGRSGSFIYQVSTHEQSESAHGRTRTSTGRRQGSHHEQARDSSR 1154
Query: 383 HGKSQ---NQVRIPSQAQEYG----HKENKI--SYQSSSTEERRLNSGEKDVQKGVSKG- 432
H SQ + +R ++ G H E + S S S + G D G S
Sbjct: 1155 HSASQEGQDTIRAHPGSRRGGRQGSHHEQSVDRSGHSGSHHSHTTSQGRSDASHGQSGSR 1214
Query: 433 SISIQT-EEKIHGKSQNQVTIPSQDQEHGHKENKMSY--QSSSTEERRLNYGGKSTQKDV 489
S S QT ++K G + ++ S Q S+ R + G S +D
Sbjct: 1215 SASRQTRKDKQSGDGSRHSGSRHHEAASWADSSRHSQVGQEQSSGSRTSRHQGSSVSQDS 1274
Query: 490 SQSSISFQIEKLV-------EGKSQIQTPNPNQDQWSGQNAKGKSGQSADSKQDLLSHEQ 542
S E+L G S+ Q+ + ++ Q + G SADS + Q
Sbjct: 1275 DSERHSDDSERLSGSASRNHHGSSREQSRDGSRHPGFHQEDRASHGHSADSSR------Q 1328
Query: 543 KGRYKQESSESHNIVITEHEVAQ 565
G + ESS SH ++ HE A+
Sbjct: 1329 SGTHHTESS-SHGQAVSSHEQAR 1350
Score = 64.3 bits (155), Expect = 3e-10
Identities = 127/593 (21%), Positives = 210/593 (35%), Gaps = 69/593 (11%)
Query: 20 AVMGQKGGSKGQLPSGSSQFP------HGQKGQHYFGQKDQQHTKSKGSFSIQHTYHVDI 73
AV GQ GS+ GSS H + + + G + H S S + H
Sbjct: 3197 AVQGQSEGSRRSRRQGSSVSQDSDSEGHSEDSERWSGSASRNHRGSVQEQSRHGSRHPRS 3256
Query: 74 NDHDWTRKSQQYDLNALHKATKSKQHLGGSQQLLNYKQEGRDHDKSKGHFHMIVI---HH 130
+ D D + T+ + G Q +++Q + G H H
Sbjct: 3257 HHEDRAGHGHSAD-RSRQSGTRHAETSSGGQAASSHEQARSSPGERHGSRHQQSADSSRH 3315
Query: 131 KG---GQAHHGTQNPSQ--DQGNSPSGKGLSSQCSNTEKRLWVHGLS-----KEQASASG 180
G GQA ++ G+ S S+ S+T+ + HG + Q SA
Sbjct: 3316 SGIPRGQASSAVRDSRHWGSSGSQASDSEGHSEESDTQS-VSGHGQAGPHQQSHQESARD 3374
Query: 181 AQKGRTQGGSQSSYVLQTEELVVNKQQRETKNSHQNKG-HYQNVVDV-REEHSSKLQTSL 238
GR+ Y + T E + R ++ + +G H++ D R S + Q ++
Sbjct: 3375 RSGGRSGRSGSFLYQVSTHEQSESAHGRTRTSTGRRQGSHHEQARDSSRHSASQEGQDTI 3434
Query: 239 --HPAHQDRLQHGPKDIFTTQDELLVYNKNQHQTKNLSQDQEHGRKAHKISYPSSRTEER 296
HP R + G + + + H T D G+ + + +R +E+
Sbjct: 3435 RGHPGSSRRGRQGSHYEQSVDRSGHSGSHHSHTTSQGRSDASRGQSGSRSASRQTRNDEQ 3494
Query: 297 Q--------LHHGEKSVQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQE-HGHKENKIS 347
HH E S Q D S+ S S Q + S+NQ + SQD + GH E+
Sbjct: 3495 SGDGSRHSWSHHHEASTQADSSRHSQSGQGQSAGPRTSRNQGSSVSQDSDSQGHSEDSER 3554
Query: 348 YQSSSTEERHLNCGEKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKIS 407
+ S S H ++ + G S+ S + HG S S+ H EN
Sbjct: 3555 W-SGSASRNHRGSAQEQSRDG-SRHPTSHHEDRAGHGHSAES----SRQSGTHHAENSSG 3608
Query: 408 YQ-SSSTEERRLNSGEKDVQKGVSKGSISIQTEEKIHGKSQNQVTIPSQDQEHGHKENKM 466
Q +SS E+ R ++GE+ HG Q S+ GH
Sbjct: 3609 GQAASSHEQARSSAGER-------------------HGSHHQQSADSSRHSGIGHG---- 3645
Query: 467 SYQSSSTEERRLNYGGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQNAKGK 526
Q+SS + G +Q S+ + V Q + + + + G+
Sbjct: 3646 --QASSAVRDSGHRGSSGSQASDSEGHSEDSDTQSVSAHGQAGPHQQSHQESTRGRSAGR 3703
Query: 527 SGQSADSKQDLLSHEQ-KGRYKQESSESHNIVITEHEVAQDD--HLTQQYNED 576
SG+S + +HEQ + + + + + HE A+D H Q +D
Sbjct: 3704 SGRSGSFLYQVSTHEQSESAHGRAGPSTGGRQGSRHEQARDSSRHSASQEGQD 3756
Score = 62.4 bits (150), Expect = 1e-09
Identities = 126/606 (20%), Positives = 212/606 (34%), Gaps = 96/606 (15%)
Query: 27 GSKGQLPSGSSQFPHGQKGQHY-FGQKDQ-QHTKSKGSFSIQHTYHVD-------INDHD 77
GS + GSS+ +H F Q+D+ H S S T+H + ++ H+
Sbjct: 1288 GSASRNHHGSSREQSRDGSRHPGFHQEDRASHGHSADSSRQSGTHHTESSSHGQAVSSHE 1347
Query: 78 WTRKSQQYDLNALHK-ATKSKQHLG-GSQQLLNYKQEGRDHDKSKGHFHMIVIHHKGGQA 135
R S + H+ + S +H G G +Q + ++ S H +
Sbjct: 1348 QARSSPGERHGSRHQQSADSSRHSGIGHRQASSAVRDSGHRGSSGSQVTNSEGHSEDSDT 1407
Query: 136 H----HGTQNPSQDQGNSPSGKGLSSQCSNTEKRLWVHGLSKEQASASGAQKGRTQGGSQ 191
HG P Q Q + S +G S + S + S EQ+ ++ Q + GG Q
Sbjct: 1408 QSVSAHGQAGPHQ-QSHKESARGQSGESSGRSRSFLYQVSSHEQSESTHGQTAPSTGGRQ 1466
Query: 192 SSYVLQTEELVVNKQQRETKNSHQNKGHYQNVVDVREEHSSK---LQTSLHPAHQDRLQH 248
S + + +NS ++ +R S Q S H DR H
Sbjct: 1467 GS------------RHEQARNSSRHSASQDGQDTIRGHPGSSRGGRQGSYHEQSVDRSGH 1514
Query: 249 GPKDIFTTQDELLVYNKNQHQTKNLSQDQEHGRKAHKISYPSSRTEERQ--------LHH 300
+ H T D HG+ + + +R EE+ H
Sbjct: 1515 SG-------------YHHSHTTPQGRSDASHGQSGPRSASRQTRNEEQSGDGSRHSGSRH 1561
Query: 301 GEKSVQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQE-HGHKENKISYQSSSTEERHLN 359
E S + S+ S Q E S+ Q + SQD++ GH E+ +S S H
Sbjct: 1562 HEPSTRAGSSRHSQVGQGESAGSKTSRRQGSSVSQDRDSEGHSEDS-ERRSESASRNHYG 1620
Query: 360 CGEKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEER-RL 418
+ + G S+ S Q + HG S S+ H E Q++S++E+ R
Sbjct: 1621 SAREQSRHG-SRNPRSHQEDRASHGHSAES----SRQSGTRHAETSSGGQAASSQEQARS 1675
Query: 419 NSGEKDVQKGVSKGSISIQT------EEKIHGKSQNQVTIPSQ-DQEHGHKENKMS---- 467
+ GE+ + S + + + G S N+ + SQ GH E +
Sbjct: 1676 SPGERHGSRHQQSADSSTDSGTGRRQDSSVVGDSGNRGSSGSQASDSEGHSEESDTQSVS 1735
Query: 468 -------YQSSSTEERRLNYGGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSG 520
+Q S E R G+S ++ S +Q+ + +S P+ +G
Sbjct: 1736 AHGQAGPHQQSHQESTR----GQSGERSGRSGSFLYQVSTHEQSESAHGRTGPS----TG 1787
Query: 521 QNAKGKSGQSADSKQDLLSHEQKGRY----------KQESSESHNIVITEHEVAQDDHLT 570
+ + Q+ DS + S E + +Q S ++ + H + H T
Sbjct: 1788 GRQRSRHEQARDSSRHSASQEGQDTIRGHPGSSRGGRQGSHYEQSVDSSGHSGSHHSHTT 1847
Query: 571 QQYNED 576
Q D
Sbjct: 1848 SQERSD 1853
Score = 59.7 bits (143), Expect = 7e-09
Identities = 133/655 (20%), Positives = 230/655 (35%), Gaps = 146/655 (22%)
Query: 23 GQKGGSKGQLPSGSSQFPHGQKGQHYFGQKDQQHTKSKGSFSIQHTYHVDINDH------ 76
G+ S+GQ SGS + + G ++ GS + + H DI+ H
Sbjct: 2823 GRSDASRGQ--SGSRSASRTTRNEEQSGDG----SRHSGSRHHEASTHADISRHSQAVQG 2876
Query: 77 --DWTRKSQQYDLNALHKA--------------TKSKQHLGGSQ-QLLNYKQEGRDHDKS 119
+ +R+S++ + + + S+ H G +Q QL + + R H +
Sbjct: 2877 QSEGSRRSRRQGSSVSQDSDSEGHSEDSERWSGSASRNHHGSAQEQLRDGSRHPRSHQED 2936
Query: 120 K-GHFHMIVIHHKGGQAHHGTQNPSQ-----DQGNSPSGKGLSSQCSNTEKRLWVHGLSK 173
+ GH H + G H T + Q +Q S +G+ S + G+
Sbjct: 2937 RAGHGHSADSSRQSGTRHTQTSSGGQAASSHEQARSSAGERHGSHHQQSADSSRHSGIGH 2996
Query: 174 EQASA----------SGAQKGRTQGGSQSSYVLQTEELVVNKQQRETKNSHQ-------- 215
QAS+ SG+Q +G S+ S T+ + + Q + SHQ
Sbjct: 2997 GQASSAVRDSGHRGYSGSQASDNEGHSEDS---DTQSVSAHGQAGSHQQSHQESARGRSG 3053
Query: 216 ----NKGHYQNVVDVREEHSSK----------LQTSLHPAHQDRLQHGPKDIFTTQDELL 261
+ G + V E+ S Q S H QD +H QD +
Sbjct: 3054 ETSGHSGSFLYQVSTHEQSESSHGWTGPSTRGRQGSRHEQAQDSSRHSASQY--GQDTIR 3111
Query: 262 VY------------------------NKNQHQTKNLSQDQEHGRKAHKISYPSSRTEERQ 297
+ + + H T D G+ + + ++R EE+
Sbjct: 3112 GHPGSSRGGRQGYHHEHSVDSSGHSGSHHSHTTSQGRSDASRGQSGSRSASRTTRNEEQS 3171
Query: 298 --------LHHGEKSVQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQE-HGHKENKISY 348
H E S D+S+ S ++Q + + +S+ Q + SQD + GH E+ +
Sbjct: 3172 GDSSRHSVSRHHEASTHADISRHSQAVQGQSEGSRRSRRQGSSVSQDSDSEGHSEDSERW 3231
Query: 349 QSSSTEERHLNCGEKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISY 408
S S H ++ + G S+ S + HG S ++ S+ H E
Sbjct: 3232 -SGSASRNHRGSVQEQSRHG-SRHPRSHHEDRAGHGHSADR----SRQSGTRHAETSSGG 3285
Query: 409 Q-SSSTEERRLNSGEKDVQKGVSKGSISIQTEEKIHGKSQNQVTIPSQDQEHGHKENKMS 467
Q +SS E+ R + GE+ HG Q S+ H
Sbjct: 3286 QAASSHEQARSSPGER-------------------HGSRHQQSADSSR-----HSGIPRG 3321
Query: 468 YQSSSTEERRLNYGGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQNAKGKS 527
SS+ + R ++G +Q S+ + V G Q + + + + G+S
Sbjct: 3322 QASSAVRDSR-HWGSSGSQASDSEGHSEESDTQSVSGHGQAGPHQQSHQESARDRSGGRS 3380
Query: 528 GQSADSKQDLLSHEQK----GRYKQESSESHNIVITEHEVAQDD--HLTQQYNED 576
G+S + +HEQ GR + + + HE A+D H Q +D
Sbjct: 3381 GRSGSFLYQVSTHEQSESAHGRTRTSTGRRQG---SHHEQARDSSRHSASQEGQD 3432
Score = 59.3 bits (142), Expect = 9e-09
Identities = 122/607 (20%), Positives = 223/607 (36%), Gaps = 69/607 (11%)
Query: 16 EKQAAVMGQKGGSKGQLPSGSSQFPHGQKGQHYFGQKDQQHTKSKGSFSIQHTYHVDIND 75
E+ + G++ GS+ Q + SS+ +GQ +D +H S GS + H + +D
Sbjct: 3292 EQARSSPGERHGSRHQQSADSSRHSGIPRGQASSAVRDSRHWGSSGSQASDSEGHSEESD 3351
Query: 76 ------HDWTRKSQQYDLNALHKATKSKQHLGGS--QQLLNYKQEGRDHDKSK-GHFHMI 126
H QQ + + + GS Q+ ++Q H +++
Sbjct: 3352 TQSVSGHGQAGPHQQSHQESARDRSGGRSGRSGSFLYQVSTHEQSESAHGRTRTSTGRRQ 3411
Query: 127 VIHHKGGQAHHGTQNPSQDQGNS-----PSGKGLSSQCSNTEKRLWVHGLSKEQASASGA 181
HH+ QA +++ + +G P Q S+ E+ + G S S + +
Sbjct: 3412 GSHHE--QARDSSRHSASQEGQDTIRGHPGSSRRGRQGSHYEQSVDRSGHSGSHHSHTTS 3469
Query: 182 Q----KGRTQGGSQSSYVLQTEELVVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTS 237
Q R Q GS+S+ R+T+N Q+ ++ E S++ +S
Sbjct: 3470 QGRSDASRGQSGSRSA-------------SRQTRNDEQSGDGSRHSWSHHHEASTQADSS 3516
Query: 238 LHPAHQDRLQHGPK-----DIFTTQDELLVYNKNQHQTKNLSQDQEHGRKAHKIS----- 287
H GP+ +QD + + + S + H A + S
Sbjct: 3517 RHSQSGQGQSAGPRTSRNQGSSVSQDSDSQGHSEDSERWSGSASRNHRGSAQEQSRDGSR 3576
Query: 288 YPSSRTEERQLH-HGEKSVQK------DVSKGSISIQTEEKIHGKSQNQVTIHSQDQEHG 340
+P+S E+R H H +S ++ + S G + + E+ + + H Q
Sbjct: 3577 HPTSHHEDRAGHGHSAESSRQSGTHHAENSSGGQAASSHEQARSSAGERHGSHHQQSADS 3636
Query: 341 HKENKISY-QSSSTEERHLNCGEKGIQKGVSKG--------SISIQTEEQIHGKSQNQVR 391
+ + I + Q+SS + G G Q S+G S+S + H +S +
Sbjct: 3637 SRHSGIGHGQASSAVRDSGHRGSSGSQASDSEGHSEDSDTQSVSAHGQAGPHQQSHQEST 3696
Query: 392 IPSQAQEYGHKENKISYQSSSTEERRLNSGEKDVQKGVSKGSISIQTEEKIHGKSQNQVT 451
A G + YQ S+ E+ G G +GS E+ S++ +
Sbjct: 3697 RGRSAGRSG-RSGSFLYQVSTHEQSESAHGRAGPSTGGRQGS----RHEQARDSSRHSAS 3751
Query: 452 IPSQDQEHGHKENKMSYQSSSTEERRLNYGGKSTQKDVSQSSISFQIEKLVEGKSQIQTP 511
QD GH ++ + S E+ ++ G S +S + S+ +
Sbjct: 3752 QEGQDTIRGHPGSRRGGRQGSYHEQSVDRSGHSGSHHSHTTSQGRSDASHGQSGSRSASR 3811
Query: 512 NPNQDQWSGQNAK--GKSGQSADSKQDLLSHEQKGRYKQESSESHNIVITEHEVAQDDHL 569
++ SG ++ G A ++ D H Q G + ES+ S V+QD
Sbjct: 3812 ETRNEEQSGDGSRHSGSRHHEASTQADSSRHSQSG--QGESAGSRRSRRQGSSVSQDSD- 3868
Query: 570 TQQYNED 576
++ Y ED
Sbjct: 3869 SEAYPED 3875
Score = 57.0 bits (136), Expect = 5e-08
Identities = 113/537 (21%), Positives = 189/537 (35%), Gaps = 74/537 (13%)
Query: 50 GQKDQQHTKSKGSFSIQHTYHVDINDHDWTRKSQQYDLNALHKATKSKQHLGGSQQLLNY 109
GQ H +++ S +H H + D +R S A A + H G S
Sbjct: 1988 GQAASSHEQARSSAGERHGSHHQLQSADSSRHSGIGHGQA-SSAVRDSGHRGYS------ 2040
Query: 110 KQEGRDHDKSKGHFHMIVIHHKGGQAHHGTQNPSQDQGNSPSGKGLSSQCSNTEKRLWVH 169
G S+GH Q G P Q Q + S +G S + S
Sbjct: 2041 ---GSQASDSEGHSEDSDTQSVSAQ---GKAGPHQ-QSHKESARGQSGESSGRSGSFLYQ 2093
Query: 170 GLSKEQASASGAQKGRTQGGSQSSYVLQTEELVVNKQQRETKNSHQNKGHYQNVVDVREE 229
+ EQ+ ++ Q + GG Q S+ Q ++ +++S +G D
Sbjct: 2094 VSTHEQSESTHGQSAPSTGGRQGSHYDQAQD--------SSRHSASQEGQ-----DTIRG 2140
Query: 230 HSSKLQTSLHPAHQ----DRLQH-GPKDIFTTQDELLVYNKNQHQTKNLSQDQEHGRKAH 284
H + +HQ DR H G TT ++ Q +++ S RK +
Sbjct: 2141 HPGPSRGGRQGSHQEQSVDRSGHSGSHHSHTTSQGRSDASRGQSGSRSAS------RKTY 2194
Query: 285 KISYPSSRTEERQLHHGEKSVQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQE-HGHKE 343
+ HH E S D S+ S+ Q + S+ + + SQD + GH E
Sbjct: 2195 DKEQSGDGSRHSGSHHHEASSWADSSRHSLVGQGQSSGPRTSRPRGSSVSQDSDSEGHSE 2254
Query: 344 NKISYQSSSTEERHLNCGEKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKE 403
+ S++ H + E+ + S+ S + HG S S+ H E
Sbjct: 2255 DSERRSGSASRNHHGSAQEQ--SRDGSRHPRSHHEDRAGHGHSAES----SRQSGTHHAE 2308
Query: 404 NKISYQ-SSSTEERRLNSGEKDVQKGVSKGSISIQTEEKIHGKSQNQVTIPSQDQEHGHK 462
N Q +SS E+ R ++GE+ HG Q S+ GH
Sbjct: 2309 NSSGGQAASSHEQARSSAGER-------------------HGSHHQQSADSSRHSGIGHG 2349
Query: 463 ENKMSYQSSSTEERRLNYGGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQN 522
Q+SS + G +Q S+ + V Q + + +
Sbjct: 2350 ------QASSAVRDSGHRGSSGSQASDSEGHSEDSDTQSVSAHGQAGPHQQSHQESTRGR 2403
Query: 523 AKGKSGQSADSKQDLLSHEQ-KGRYKQESSESHNIVITEHEVAQDD--HLTQQYNED 576
+ G+SG+S + +HEQ + + + + + + H+ A+D H T Q +D
Sbjct: 2404 SAGRSGRSGSFLYQVSTHEQSESAHGRTGTSTGGRQGSHHKQARDSSRHSTSQEGQD 2460
Score = 56.6 bits (135), Expect = 6e-08
Identities = 109/556 (19%), Positives = 192/556 (34%), Gaps = 73/556 (13%)
Query: 24 QKGGSKGQLPSGSSQF--PHGQKGQHYFGQKDQQHTKSKGSFSIQHTYHVDINDHDWTRK 81
Q S+G +Q G+ G H K+ +S S ++ ++ H+ +
Sbjct: 2043 QASDSEGHSEDSDTQSVSAQGKAGPHQQSHKESARGQSGESSGRSGSFLYQVSTHEQSES 2102
Query: 82 SQQYDLNALHKATKSKQHLGGSQQLLNYKQEGRDHDKSKGHFHMIVIHHKGGQAHHGTQN 141
+ + +A + H +Q + D +GH G + G Q
Sbjct: 2103 T--HGQSAPSTGGRQGSHYDQAQDSSRHSASQEGQDTIRGH---------PGPSRGGRQG 2151
Query: 142 PSQDQGNSPSGKGLSSQCSNTEKRLWVHGLSKEQASASGAQKGRTQGGSQSSYVLQTEEL 201
Q+Q SG S H S+ ++ AS Q G ++ S+ +Y
Sbjct: 2152 SHQEQSVDRSGHSGSHHS---------HTTSQGRSDASRGQSG-SRSASRKTY------- 2194
Query: 202 VVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHPAHQDRLQHGPKDI-----FTT 256
+K+Q + H H+ E SS +S H GP+ +
Sbjct: 2195 --DKEQSGDGSRHSGSHHH--------EASSWADSSRHSLVGQGQSSGPRTSRPRGSSVS 2244
Query: 257 QDELLVYNKNQHQTKNLSQDQEHGRKAHKIS-----YPSSRTEERQLH-HGEKSVQK--- 307
QD + + ++ S + H A + S +P S E+R H H +S ++
Sbjct: 2245 QDSDSEGHSEDSERRSGSASRNHHGSAQEQSRDGSRHPRSHHEDRAGHGHSAESSRQSGT 2304
Query: 308 ---DVSKGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISY-QSSSTEERHLNCGEK 363
+ S G + + E+ + + H Q + + I + Q+SS + G
Sbjct: 2305 HHAENSSGGQAASSHEQARSSAGERHGSHHQQSADSSRHSGIGHGQASSAVRDSGHRGSS 2364
Query: 364 GIQKGVSKG--------SISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEE 415
G Q S+G S+S + H +S + A G + YQ S+ E+
Sbjct: 2365 GSQASDSEGHSEDSDTQSVSAHGQAGPHQQSHQESTRGRSAGRSG-RSGSFLYQVSTHEQ 2423
Query: 416 RRLNSGEKDVQKGVSKGSISIQTEEKIHGKSQNQVTIPSQDQEHGHKENKMSYQSSSTEE 475
G G +GS Q + S++ + QD HGH + + S E
Sbjct: 2424 SESAHGRTGTSTGGRQGSHHKQARDS----SRHSTSQEGQDTIHGHPGSSSGGRQGSHYE 2479
Query: 476 RRLNYGGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQNAK--GKSGQSADS 533
+ ++ G S +S S+ + D+ SG ++ G A S
Sbjct: 2480 QLVDRSGHSGSHHSHTTSQGRSDASHGHSGSRSASRQTRNDEQSGDGSRHSGSRHHEASS 2539
Query: 534 KQDLLSHEQKGRYKQE 549
+ D H Q G+ + E
Sbjct: 2540 RADSSGHSQVGQGQSE 2555
Score = 51.2 bits (121), Expect = 3e-06
Identities = 97/461 (21%), Positives = 158/461 (34%), Gaps = 75/461 (16%)
Query: 35 GSSQFPHGQKGQHYF-----GQKDQQHTKSKGSFSIQHTYHVDINDHDWTRKSQQYD--- 86
G S Q G H+ GQ H +++ S +H H H + S ++
Sbjct: 3589 GHSAESSRQSGTHHAENSSGGQAASSHEQARSSAGERHGSH-----HQQSADSSRHSGIG 3643
Query: 87 LNALHKATKSKQHLGGSQQLLNYKQEGRDHDKSKGHFHMIVIHHKGGQAHHGTQNPSQDQ 146
A + H G S G S+GH + HG P Q Q
Sbjct: 3644 HGQASSAVRDSGHRGSS---------GSQASDSEGHSED---SDTQSVSAHGQAGPHQ-Q 3690
Query: 147 GNSPSGKGLSSQCSNTEKRLWVHGLSKEQASASGAQKGRTQGGSQSSYVLQTEELVVNKQ 206
+ S +G S+ S + EQ+ ++ + G + GG Q S +
Sbjct: 3691 SHQESTRGRSAGRSGRSGSFLYQVSTHEQSESAHGRAGPSTGGRQGS------------R 3738
Query: 207 QRETKNSHQNKGHYQNVVDVREEHSSKL---QTSLHPAHQDRLQHGPKDIFTTQDELLVY 263
+ ++S ++ + +R S+ Q S H DR H
Sbjct: 3739 HEQARDSSRHSASQEGQDTIRGHPGSRRGGRQGSYHEQSVDRSGHSG------------- 3785
Query: 264 NKNQHQTKNLSQDQEHGRKAHKISYPSSRTEERQ--------LHHGEKSVQKDVSKGSIS 315
+ + H T D HG+ + + +R EE+ H E S Q D S+ S S
Sbjct: 3786 SHHSHTTSQGRSDASHGQSGSRSASRETRNEEQSGDGSRHSGSRHHEASTQADSSRHSQS 3845
Query: 316 IQTEEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSSTEERHLNCGEKGIQKGVSKGSIS 375
Q E +S+ Q + SQD + +S S H + + G S+ S
Sbjct: 3846 GQGESAGSRRSRRQGSSVSQDSDSEAYPEDSERRSESASRNHHGSSREQSRDG-SRHPGS 3904
Query: 376 IQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEERRLNSGEKDVQKGVSKGSIS 435
+ H +S S A+E+GH SS +++ +SG + S S
Sbjct: 3905 SHRDTASHVQSSPVQSDSSTAKEHGH-------FSSLSQDSAYHSGIQSRGSPHSSSSYH 3957
Query: 436 IQTEEKIHGKSQNQV-----TIPSQDQEHGHKENKMSYQSS 471
Q+E K Q+ + + S D ++G + S S
Sbjct: 3958 YQSEGTERQKGQSGLVWRHGSYGSADYDYGESGFRHSQHGS 3998
Score = 48.1 bits (113), Expect = 2e-05
Identities = 105/565 (18%), Positives = 191/565 (33%), Gaps = 88/565 (15%)
Query: 23 GQKGGSKGQLPSGSSQFPHGQKGQHYF-GQKDQQHTKSKGSFSIQHTYHVDINDHDWTRK 81
G + GS + SS+ Q+GQ G +GS H V+ + H +
Sbjct: 490 GGRQGSHHEQARDSSRHSASQEGQDTIRGHPGSSRGGRQGS---HHEQSVNRSGHSGSHH 546
Query: 82 SQ---QYDLNALHKATKSKQHLGGSQQLLNYKQEGRDHDKSKGHFHMIVIHHKGGQAHHG 138
S Q +A H + S+ S+Q N +Q G G H HH+
Sbjct: 547 SHTTSQGRSDASHGQSGSRS---ASRQTRNEEQSG------DGTRHSGSRHHEASSQADS 597
Query: 139 TQNPSQDQGNSPSGKGLSSQCSNTEKRLWVHGLSKEQASASGAQKGRTQGGSQSSYVLQT 198
+++ QG S + +Q S+ + G S++ SG+ G +Q
Sbjct: 598 SRHSQVGQGQSSGPRTSRNQGSSVSQDSDSQGHSEDSERWSGSASRNHHGSAQEQ----- 652
Query: 199 EELVVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHPAHQDRLQHGPKDIFTTQD 258
R ++ H+++ + + D SS+ + H TQ+
Sbjct: 653 ----SRDGSRHPRSHHEDRAGHGHSAD-----SSRKSGTRH----------------TQN 687
Query: 259 ELLVYNKNQHQTKNLSQDQEHGRKAHKISYPSSR---TEERQL--------HHGEKSVQK 307
+ H+ S + HG + S SSR T Q H G Q
Sbjct: 688 SSSGQAASSHEQARSSAGERHGSRHQLQSADSSRHSGTGHGQASSAVRDSGHRGSSGSQA 747
Query: 308 DVSKGSISIQTEEKIHGKSQ-------NQVTIHSQDQEHGHKENKISYQSSSTEERHLNC 360
S+G + + G Q +Q + + E + YQ S+ ++ +
Sbjct: 748 TDSEGHSEDSDTQSVSGHGQAGHHQQSHQESARDRSGERSRRSGSFLYQVSTHKQSESSH 807
Query: 361 GEKGIQKGVSKGSISIQTEEQI-HGKSQN-------QVRIPSQAQEYGHKENKI--SYQS 410
G G GV +GS Q + H SQ+ + ++ H E + S S
Sbjct: 808 GWTGPSTGVRQGSHHEQARDNSRHSASQDGQDTIRGHPGSSRRGRQGSHHEQSVDRSGHS 867
Query: 411 SSTEERRLNSGEKDVQKGVSKGSISIQTEEKIHGKSQNQVTIPSQDQEHGHKENKMSYQS 470
S + G D +G S + +T ++N+ + G + ++ S +
Sbjct: 868 GSHHSHTTSQGRSDASRGQSGSRSASRT-------TRNEEQSRDGSRHSGSRHHEASSHA 920
Query: 471 SSTEERRLNYGGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQNAKGKSGQS 530
+ + G + + S + EG S+ + ++WSG ++ G S
Sbjct: 921 DISRHSQAGQGQSEGSRTSRRQGSSVSQDSDSEGHSE------DSERWSGSASRNHRG-S 973
Query: 531 ADSKQDLLSHEQKGRYKQESSESHN 555
A + S + ++ + H+
Sbjct: 974 AQEQSRHGSRHPRSHHEDRAGHGHS 998
Score = 46.6 bits (109), Expect = 6e-05
Identities = 113/584 (19%), Positives = 195/584 (33%), Gaps = 77/584 (13%)
Query: 29 KGQLP-SGSSQFPHGQKGQHYFGQKDQQHTKSKGSFSIQHTYHVDINDHDWTRKSQQYDL 87
K LP SG H +H ++++ K S++ + N KS +
Sbjct: 91 KENLPISGHKHRKHSHHDKHEDNKQEENKENRKRPSSLERRNNRKGNKG--RSKSPRETG 148
Query: 88 NALHKATKSKQHLGGSQQLLNYKQEGRDHDKSKGHFHMIVIHHKGGQAHHGTQNPSQDQG 147
H+++ K+ G Y R+ + K H H+ + + T+N
Sbjct: 149 GKRHESSSEKKERKG------YSPTHREEEYGKNH------HNSSKKEKNKTENTRLGDN 196
Query: 148 NSPSGKGLSSQCSNTEKRLWVHGLSKEQASASGAQKGRTQGGSQSSYVLQTEELVVN--- 204
+ L + N E G+ + + QK G + Y +Q E
Sbjct: 197 RKRLSERLEEKEDNEE------GVYDYENTGRMTQKWIQSGHIATYYTIQDEAYDTTDSL 250
Query: 205 -KQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHPAHQDRLQHGPKDIFTTQDELLVY 263
++ + + S + G + V+ R H + Q L + + R + G + +QD
Sbjct: 251 LEENKIYERSRSSDGKSSSQVN-RSRHENTSQVPLQES-RTRKRRGSR---VSQDRDSEG 305
Query: 264 NKNQHQTKNLSQDQEHGRKAHKIS-----YPSSRTEERQLHHGEKSVQKDVSKGSISIQT 318
+ + + S + H A + S +P S E+R H S G+ +T
Sbjct: 306 HSEDSERHSGSASRNHHGSAWEQSRDGSRHPRSHDEDRASHG--HSADSSRQSGTRHAET 363
Query: 319 EEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSSTEERHLNCGEKGIQKGVS----KGSI 374
+ S ++ S + HG +Q S+ RH G VS +GS
Sbjct: 364 SSRGQTASSHEQARSSPGERHGS-----GHQQSADSSRHSATGRGQASSAVSDRGHRGSS 418
Query: 375 SIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEERRLNSGEKDVQKGVSKGSI 434
Q + G S+N S Q Q S E R SGE+ + G S +
Sbjct: 419 GSQASDS-EGHSEN-----SDTQSVSGHGKAGLRQQSHQESTRGRSGERSGRSGSSLYQV 472
Query: 435 SIQTE-EKIHGK-------------------SQNQVTIPSQDQEHGHKENKMSYQSSSTE 474
S + + HG+ S++ + QD GH + + S
Sbjct: 473 STHEQPDSAHGRTGTSTGGRQGSHHEQARDSSRHSASQEGQDTIRGHPGSSRGGRQGSHH 532
Query: 475 ERRLNYGGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQNAK--GKSGQSAD 532
E+ +N G S +S + S+ + ++ SG + G A
Sbjct: 533 EQSVNRSGHSGSHHSHTTSQGRSDASHGQSGSRSASRQTRNEEQSGDGTRHSGSRHHEAS 592
Query: 533 SKQDLLSHEQKGRYKQESSESHNIVITEHEVAQDDHLTQQYNED 576
S+ D H Q G Q S + D +Q ++ED
Sbjct: 593 SQADSSRHSQVG---QGQSSGPRTSRNQGSSVSQDSDSQGHSED 633
>gi|62122917 filaggrin family member 2 [Homo sapiens]
Length = 2391
Score = 62.0 bits (149), Expect = 1e-09
Identities = 118/567 (20%), Positives = 186/567 (32%), Gaps = 100/567 (17%)
Query: 23 GQKGGSKGQLPSGSSQFPHGQKGQHYFGQKDQQHTKSKGSFS----IQHTYHVDINDHDW 78
G S ++ SG S G H GQ QH +S+ I H D H +
Sbjct: 1500 GHSESSDSEVHSGGSHTHSG----HTHGQSGSQHGESESIIHDRHRITHGQTGDTTRHSY 1555
Query: 79 TRKSQQYDLNAL---------HKATKSKQHLGGSQQLLN----YKQEGRDHDKSKGHFHM 125
+ Q + ++T S+ H GGS + + Y Q G H++ +
Sbjct: 1556 SGHEQTTQTGSRTTGRQRTSHSESTDSEVHSGGSHRPHSREHTYGQAGSQHEEPE----- 1610
Query: 126 IVIHHKGGQAH----------HGTQNPSQDQGNSPSGKGLSSQCSNTEKRLWVH-GLSKE 174
+H + G H H S +G+ +G+ SS +++ VH G+S
Sbjct: 1611 FTVHERHGTTHGQIGDTTGHSHSGHGQSTQRGSRTTGRQRSSHSESSDSE--VHSGVSHT 1668
Query: 175 QASASGAQKGRTQGGSQSSYVLQTEELVVNKQQRETKNSHQN--------------KGHY 220
+ Q G +Q G S V + + T+++H + +G
Sbjct: 1669 HTGHTHGQAG-SQHGQSESIVPERHGTTHGQTGDTTRHAHYHHGLTTQTGSRTTGRRGSG 1727
Query: 221 QNVVDVREEHSSKLQT-SLHPAHQDRLQHGPKDIFTTQDELLVYNKNQHQTKNLSQDQEH 279
+ E +S T S H Q R QHG + E +V+ ++ H
Sbjct: 1728 HSEYSDSEGYSGVSHTHSGHTHGQARSQHG-------ESESIVHERHGTIHGQTGDTTRH 1780
Query: 280 GRKAH-KISYPSSRTEERQLHHGEKSVQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQE 338
H + + SRT R+ S G E G SQ HS+
Sbjct: 1781 AHSGHGQSTQTGSRTTGRR------------SSGHSEYSDSEGHSGFSQRP---HSRGHT 1825
Query: 339 HGHKENKISYQSSSTEERH-LNCGEKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQ 397
HG ++ S +ERH G+ G G S+ HG+S + +
Sbjct: 1826 HGQAGSQHGESESIVDERHGTTHGQTGDTSGHSQSG---------HGQSTQSGSSTTGRR 1876
Query: 398 EYGHKENKISYQSSSTEERRLNSGEKDVQKGVSKGSISIQTEEKIHGKSQNQVTIPSQDQ 457
GH E+ S S +SG Q G ++E +H + Q
Sbjct: 1877 RSGHSESSDSEVHSGGSHT--HSGHTHSQARSQHG----ESESTVHKRHQTTHGQTGDTT 1930
Query: 458 EHGHKENKMSYQSSSTEERRLNYGGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQ 517
EHGH + + Q+ S R G S +S G++ P
Sbjct: 1931 EHGHPSHGQTIQTGSRTTGRRGSGHSEYSDSEGPSGVSHTHSGHTHGQAGSHYPE----- 1985
Query: 518 WSGQNAKGKSGQSADSKQDLLSHEQKG 544
SG + + G + D H G
Sbjct: 1986 -SGSSVHERHGTTHGQTADTTRHGHSG 2011
Score = 55.5 bits (132), Expect = 1e-07
Identities = 120/588 (20%), Positives = 200/588 (34%), Gaps = 67/588 (11%)
Query: 18 QAAVMGQKGGSKGQLPSGSSQFPHGQKGQHYFGQKDQQHTKSKGSFSIQHTYHVDINDHD 77
Q++ GQ G G+ SG +Q + + GQ +GQ ++S G QH
Sbjct: 1124 QSSGFGQHGSGTGK-SSGFAQHEY-RSGQSSYGQHGTGSSQSSGCG--QH------ESGS 1173
Query: 78 WTRKSQQYDLNALHKATKSKQHLGGSQQLLNYKQEGRDHDKSKGHFHMIVIHHKGGQAHH 137
S ++ + S QH+ S Q + Q G +S G + G H
Sbjct: 1174 GPTTSFGQHVSGSDNFSSSGQHISDSGQSTGFGQYGSGSGQSTGLGQGESQQVESGSTVH 1233
Query: 138 GTQNPSQDQG-----NSPSGKGLSSQCSNTEKRLWVHGLSKE-------QASASGAQKGR 185
G Q + Q +S SG+G S+Q + R S+ + S ++
Sbjct: 1234 GRQETTHGQTINTTRHSQSGQGQSTQTGSRVTRRRRSSQSENSDSEVHSKVSHRHSEHIH 1293
Query: 186 TQGGS---QSSYVLQTEELVVNKQQRETKNSHQNKGHYQNVVD-------VREEHSSKLQ 235
TQ GS +S ++ + + Q+ +T H + GH Q+ R HS
Sbjct: 1294 TQAGSHYPKSGSTVRRRQGTTHGQRGDTTR-HGHSGHGQSTQTGSRTSGRQRFSHSDATD 1352
Query: 236 TSLHPA-----HQDRLQHGPKDIFTTQDELLVYNKNQHQTKNLSQDQEHGRKAHKISYP- 289
+ +H H H + E V+ +++ + HG H S
Sbjct: 1353 SEVHSGVSHRPHSQEQTHSQAGSQHGESESTVHERHETTYGQTGEATGHGHSGHGQSTQR 1412
Query: 290 -SSRTEERQLHHGEKSVQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISY 348
S T R H E S + S GS Q++E+ HG++ +Q S HG
Sbjct: 1413 GSRTTGRRGSGHSESSDSEVHSGGSHRPQSQEQTHGQAGSQHG-ESGSTVHGRHGTTHGQ 1471
Query: 349 QSSSTEERHLNCGEKGIQKGVSKGSISIQTEEQIHGK-SQNQVRIPSQAQEYGHKENKIS 407
+T H + G K +GS + H + S ++V GH +
Sbjct: 1472 TGDTTRHAHYHHG-----KSTQRGSSTTGRRGSGHSESSDSEVHSGGSHTHSGHTHGQSG 1526
Query: 408 YQSSSTE-----ERRLNSGE--KDVQKGVSKGSISIQTEEKIHGKSQNQVTIPSQDQEHG 460
Q +E R+ G+ + S + QT + G+ + + + + H
Sbjct: 1527 SQHGESESIIHDRHRITHGQTGDTTRHSYSGHEQTTQTGSRTTGRQRTSHSESTDSEVH- 1585
Query: 461 HKENKMSYQSSSTEERRLNYGGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSG 520
S S R YG +Q + + ++ + G + Q + SG
Sbjct: 1586 ------SGGSHRPHSREHTYGQAGSQHEEPEFTVHER-----HGTTHGQIGDTTGHSHSG 1634
Query: 521 QNAKGKSGQSADSKQDLLSHEQKGRYKQESSESHNIVITEHEVAQDDH 568
+ G +Q SH + + S SH H A H
Sbjct: 1635 HGQSTQRGSRTTGRQ-RSSHSESSDSEVHSGVSHTHTGHTHGQAGSQH 1681
Score = 53.1 bits (126), Expect = 7e-07
Identities = 115/539 (21%), Positives = 175/539 (32%), Gaps = 89/539 (16%)
Query: 34 SGSSQFPHGQKGQHYFGQKDQQHTKSKGSFSIQH-TYHVDINDHDWTRKSQQYDLNALHK 92
SG SQ PH + H GQ QH +S+ +H T H D +S
Sbjct: 1813 SGFSQRPHSRGHTH--GQAGSQHGESESIVDERHGTTHGQTGDTSGHSQSGHGQSTQSGS 1870
Query: 93 ATKSKQHLGGSQQLLNYKQEGRDHDKSKGHFHMIVIH---------HKGGQAHHGTQNPS 143
+T ++ G S+ + G H S GH H HK Q HG +
Sbjct: 1871 STTGRRRSGHSESSDSEVHSGGSHTHS-GHTHSQARSQHGESESTVHKRHQTTHGQTGDT 1929
Query: 144 QDQGNSPSGKGLSSQCSNTEKRLWVHGLSKEQASASGAQ---KGRTQGGSQSSYVLQTEE 200
+ G+ G+ + + T +R H + SG G T G + S Y
Sbjct: 1930 TEHGHPSHGQTIQTGSRTTGRRGSGHSEYSDSEGPSGVSHTHSGHTHGQAGSHYPESGSS 1989
Query: 201 L-----VVNKQQRETKNSHQNKGHYQNV----------------VDVREEHSSKLQTSLH 239
+ + Q +T H + GH Q+ E HS T
Sbjct: 1990 VHERHGTTHGQTADTTR-HGHSGHGQSTQRGSRTTGRRASGHSEYSDSEGHSGVSHTHSG 2048
Query: 240 PAH-QDRLQHGPKDIFTTQDELLVYNKNQHQTKNL-----SQDQEHGRKAHKISYPSSRT 293
AH Q QHG + + + T++ Q R A + S +
Sbjct: 2049 HAHGQAGSQHGESGSSVHERHGTTHGQTGDTTRHAHSGHGQSTQRGSRTAGRRGSGHSES 2108
Query: 294 EERQLHHGEKSVQKDVSKGSISIQTEEK---IHGKSQNQVTIHSQDQE--------HGHK 342
+ ++H G + G Q E IHG+ Q TIH Q + HG
Sbjct: 2109 SDSEVHSGVSHTHSGHTYGQARSQHGESGSAIHGR---QGTIHGQTGDTTRHGQSGHGQS 2165
Query: 343 ---------ENKISYQSSSTEERH-----LNCGEKGIQKGVSKGSISIQTEEQIHGKSQN 388
+ S+ SS E H + G Q G G S + G +
Sbjct: 2166 TQTGSRTTGRQRSSHSESSDSEVHSEASPTHSGHTHSQAGSRHGQ-SGSSGHGRQGTTHG 2224
Query: 389 QVRIPSQAQEYGHKENKISYQSSSTEERR----LNSGEKDVQKGVSK----------GSI 434
Q ++ YG+ ++ + + S T RR S + +V S GS
Sbjct: 2225 QTGDTTRHAHYGYGQS--TQRGSRTTGRRGSGHSESSDSEVHSWGSHTHSGHIQGQAGSQ 2282
Query: 435 SIQTEEKIHGKSQNQVTIPSQDQEHGHKENKMSYQSSSTEERRLNYGGKSTQKDVSQSS 493
Q +HG+ + HGH S Q+ S R ++ S+++ SS
Sbjct: 2283 QRQPGSTVHGRLETTHGQTGDTTRHGHSGYGQSTQTGSRSSRASHFQSHSSERQRHGSS 2341
Score = 35.8 bits (81), Expect = 0.11
Identities = 128/555 (23%), Positives = 178/555 (32%), Gaps = 110/555 (19%)
Query: 30 GQLPSGSSQFPHGQKGQHYFGQKDQ-QHTKSKGSFSIQHTY------HVDINDHDW-TRK 81
GQ SG SQ GQH +G + ++ S FS Y H +
Sbjct: 381 GQYGSGGSQ--SCSNGQHEYGSCGRFSNSSSSNEFSKCDQYGSGSSQSTSFEQHGTGLSQ 438
Query: 82 SQQYDLNALHKATKSKQHLGGSQQLLNYKQEGRDHDKSKGHFHMIVIHHKGGQAHHGTQN 141
S ++ + QH S Q L Y Q G K+ G H G G
Sbjct: 439 SSGFEQHVCGSGQTCGQHESTSSQSLGYDQHGSSSGKTSGFGQ----HGSGSGQSSGFGQ 494
Query: 142 PSQDQGNSPSGKGLSSQCSNTEKRLWVHGLSKEQASASGAQKGRTQGGSQSSYVLQTEEL 201
G S SG G S HG Q+S G + R++ QSSY
Sbjct: 495 CGSGSGQS-SGFGQHGSVSGQSSGFGQHGSVSGQSSGFGQHESRSR---QSSY------- 543
Query: 202 VVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHPAHQDRLQHGPKDIFTTQDELL 261
+ S Q+ G+ Q + S+ +TS H L G F
Sbjct: 544 -----GQHGSGSSQSSGYGQ--------YGSR-ETSGFGQH--GLGSGQSTGFGQ----- 582
Query: 262 VYNKNQHQTKNLSQDQEHGRKAHKISYPSSRTEERQLHHGEKSVQKDVSKGSISIQTEEK 321
Y Q+ Q HG S SS + + G+ S + S
Sbjct: 583 -YGSGSGQSSGFGQ---HGSG----SGQSSGFGQHESRSGQSSYGQHSS----------- 623
Query: 322 IHGKSQNQVTIHSQDQEHGHKENKISYQSSSTEERHLNCGEKGIQKGVSKG-SISIQTEE 380
G SQ+ S +HG ++ Q S + G+ G G S G +
Sbjct: 624 --GSSQS-----SGYGQHGSRQTSGFGQHGSGSSQSTGFGQYGSGSGQSSGFGQHVSGSG 676
Query: 381 QIHGKSQNQVRI-----------PSQAQEYGHKENKISYQSSSTEERRLNSGEKDV--QK 427
Q G Q++ R SQ+ YG + S Q+S + L+SG+ Q
Sbjct: 677 QSSGFGQHESRSGHSSYGQHGFGSSQSSGYG-QHGSSSGQTSGFGQHELSSGQSSSFGQH 735
Query: 428 GVSKGSISIQTEEKIHGKSQNQVTIPSQDQEHGHKENKMSY-QSSSTEERRLNYGGKSTQ 486
G G S + HG Q S +H + + SY Q SS + YG ++
Sbjct: 736 GSGSGQSSGFGQ---HGSGSGQ---SSGFGQHESRSGQSSYGQHSSGSSQSSGYGQHGSR 789
Query: 487 KDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQNAKGKSGQSADSKQDLLSHEQKGRY 546
+ G Q +Q GQ G SGQSA Q Q +
Sbjct: 790 Q--------------TSGFGQ-HGSGSSQSTGFGQYGSG-SGQSAGFGQHGSGSGQSSGF 833
Query: 547 KQESSESHNIVITEH 561
Q S SH +H
Sbjct: 834 GQHESRSHQSSYGQH 848
>gi|42560244 peptidylprolyl isomerase G [Homo sapiens]
Length = 754
Score = 55.8 bits (133), Expect = 1e-07
Identities = 59/298 (19%), Positives = 122/298 (40%), Gaps = 36/298 (12%)
Query: 264 NKNQHQTKNLSQDQEHGRKAHKISYPSSRTEERQLHHGEKSVQKDVSKGSISIQTEEKIH 323
++N ++ N ++E K HK S ++ER + S + D K + + + K
Sbjct: 409 HRNVSESPNRKNEKEKKVKDHK-----SNSKERDIRRN--SEKDDKYKNKVKKRAKSKSR 461
Query: 324 GKSQNQVTIHSQDQEHGHKENKISYQSSSTEERHLNCGEKGIQKGVSKGSISIQTEEQIH 383
KS+ + +D +H E K +S S H N EK + +
Sbjct: 462 SKSKEKSKSKERDSKHNRNEEK-RMRSRSKGRDHENVKEK-------------EKQSDSK 507
Query: 384 GKSQNQVRIPSQAQEYGHKENKISYQSSSTEERRLNSGEKDVQKGVSKGSISIQTEEKIH 443
GK Q + R ++++ K N+ + S ++RR S ++ K S + +T E+
Sbjct: 508 GKDQERSRSKEKSKQLESKSNEHDHSKSKEKDRRAQSRSRECDITKGKHSYNSRTRERSR 567
Query: 444 GKSQN-QVTIPSQDQE-------HGHKENKMSYQSSSTEERRLNYGGKSTQKDVSQSSIS 495
+ ++ +V + D++ H ++E + + S R G+S KD +
Sbjct: 568 SRDRSRRVRSRTHDRDRSRSKEYHRYREQEYRRRGRSRSRERRTPPGRSRSKDRRRRRRD 627
Query: 496 FQIEKLVEGKSQIQTPNPNQDQWSGQNAKGK-SGQSADSKQDLLSHEQKGRYKQESSE 552
+ + E +S+ N+D++ Q +K ++++S++ + S + S E
Sbjct: 628 SRSSEREESQSR------NKDKYRNQESKSSHRKENSESEKRMYSKSRDHNSSNNSRE 679
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 53.1 bits (126), Expect = 7e-07
Identities = 69/376 (18%), Positives = 160/376 (42%), Gaps = 41/376 (10%)
Query: 152 GKGLSS-----QCSNTEKRLWVHGLSKEQASASGAQKGRTQGGSQSSYVLQTEELVVNKQ 206
GK L S Q E LW + L+++Q Q+ + Q + +Q +E + +Q
Sbjct: 332 GKELQSVSAKLQAQVEENELW-NRLNQQQEEKMWRQEEKIQEWEEK---IQEQEEKIREQ 387
Query: 207 QRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHPAHQDRLQHGPKDIFTTQDELLVYNKN 266
+ + + + + ++ +EE + Q + +++++ + ++ ++++ +
Sbjct: 388 EEKIREQEEKMRRQEEMMWEKEEKMRR-QEEMMWEKEEKMRRQEEMMWEKEEKIRELEEK 446
Query: 267 QHQTKNLSQDQEHGRKAHKISYPSSRTE--------ERQLHHGEKSVQKDVSKGSISIQT 318
H+ + + + +E ++ KI R E E ++ E+ +++ K +
Sbjct: 447 MHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEK---MWRQ 503
Query: 319 EEKIHGKSQNQVTIHSQDQEH-GHKENKISYQSSSTEERH-LNCGEKGIQKGVSKGSISI 376
EEKIH + + + Q+QE +E KI Q ++ ++ E+ I+K K
Sbjct: 504 EEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEK---MW 560
Query: 377 QTEEQIHGKSQN-----------QVRIPSQAQEYGHKENKISYQSSSTEERRLNSGEKDV 425
+ EE++H + + + +I Q ++ +E KI Q T+E+ GE++
Sbjct: 561 RQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQE- 619
Query: 426 QKGVSKGSISIQTEEKIHGKSQNQVTIPSQDQEHGHKENKMSYQSSSTEERRLNYGGKST 485
+K + + EEK+ + + I Q+++ +E K+ Q +E+ +
Sbjct: 620 EKMCEQEEKMQEQEEKMRRQEEK---IREQEKKIREQEEKIREQEEMMQEQEEKMWEQEE 676
Query: 486 QKDVSQSSISFQIEKL 501
+ + + Q EK+
Sbjct: 677 KMCEQEEKMQEQEEKM 692
>gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens]
Length = 494
Score = 51.2 bits (121), Expect = 3e-06
Identities = 63/338 (18%), Positives = 134/338 (39%), Gaps = 25/338 (7%)
Query: 259 ELLVYNKNQHQTKNLSQDQEHGRKAHKI----------SYPSSRTEERQLHHGEKSVQKD 308
E + Y+ + + L + +GRK + SY SR+ R S +K
Sbjct: 146 EFVSYSDMKRALEKLDGTEVNGRKIRLVEDKPGSRRRRSYSRSRSHSRSRSRSRHS-RKS 204
Query: 309 VSKGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSSTEERHLNCGEKGIQKG 368
S+ S + K +S++ S+ + ++ + S + + EK +
Sbjct: 205 RSRSGSSKSSHSKSRSRSRSGSRSRSKSRSRSQSRSRSKKEKSRSPSK-----EKSRSRS 259
Query: 369 VSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEERRLNSGEK-DVQK 427
S G ++++Q K QN + + S S ++ERR+ ++ V +
Sbjct: 260 HSAGKSRSKSKDQAEEKIQNNDNVGKPKSRSPSRHKSKSKSRSRSQERRVEEEKRGSVSR 319
Query: 428 GVSKGSISIQTEEKIHGK----SQNQVTIPSQDQEHGHKENKMSYQSSSTEERRLNYGGK 483
G S+ Q+ + K S+++ S+D+ G K ++ +S S + K
Sbjct: 320 GRSQEKSLRQSRSRSRSKGGSRSRSRSRSKSKDKRKGRKRSREESRSRSRSRSKSERSRK 379
Query: 484 STQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQNAKGKSGQ---SADSKQDLLSH 540
K S++ S + +K +SQ ++P+ + + ++AK +S Q +S+ +
Sbjct: 380 RGSKRDSKAGSSKKKKKEDTDRSQSRSPSRSVSK-EREHAKSESSQREGRGESENAGTNQ 438
Query: 541 EQKGRYKQESSESHNIVITEHEVAQDDHLTQQYNEDRN 578
E + R + S N+ ++ T+ ++ R+
Sbjct: 439 ETRSRSRSNSKSKPNLPSESRSRSKSASKTRSRSKSRS 476
Score = 43.1 bits (100), Expect = 7e-04
Identities = 56/324 (17%), Positives = 118/324 (36%), Gaps = 20/324 (6%)
Query: 169 HGLSKEQASASGAQKGRTQGGSQSSYVLQTEELVVNKQQRETKNSHQNKGHYQNVVDVRE 228
H S+ ++ S + R+ G S+SS+ + R S R
Sbjct: 191 HSRSRSRSRHSRKSRSRS-GSSKSSHSKSRSRSRSGSRSRSKSRSRSQSRSRSKKEKSRS 249
Query: 229 EHSSKLQTSLHPAHQDRLQHGPKDIFTTQDELLVYNKNQHQTKNLSQDQEHGRKAHKISY 288
K ++ H A + R + KD +E + N N + K+ S + + +
Sbjct: 250 PSKEKSRSRSHSAGKSRSKS--KD---QAEEKIQNNDNVGKPKSRSPSRHKSKSKSRSRS 304
Query: 289 PSSRTEERQLHHGEKSVQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISY 348
R EE + + ++ S ++ K +S+++ S+D+ G K ++
Sbjct: 305 QERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGSRSRSRSRSKSKDKRKGRKRSREES 364
Query: 349 QSSSTEERHLNCGEKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISY 408
+S S K K SK S + +++ +SQ++ S ++E H +++ S
Sbjct: 365 RSRSRSRSKSERSRKRGSKRDSKAGSSKKKKKEDTDRSQSRSPSRSVSKEREHAKSESSQ 424
Query: 409 QSSSTEERRLNSGEKDVQKGVSKGSISIQTEEKIHGKSQNQVTIPSQDQEHGHKENKMSY 468
+ E + + +T + S+++ +PS+ + +K
Sbjct: 425 REGRGESENAGTNQ--------------ETRSRSRSNSKSKPNLPSESRSRSKSASKTRS 470
Query: 469 QSSSTEERRLNYGGKSTQKDVSQS 492
+S S +S + S+S
Sbjct: 471 RSKSRSRSASRSPSRSRSRSHSRS 494
>gi|212549782 caspase 8 associated protein 2 [Homo sapiens]
Length = 1982
Score = 50.4 bits (119), Expect = 4e-06
Identities = 88/422 (20%), Positives = 160/422 (37%), Gaps = 94/422 (22%)
Query: 193 SYVLQTEELVVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHPAHQDRLQHGPKD 252
S +++T + +N++ E N HQ + + R H + D ++ KD
Sbjct: 116 SALIKTARVEINRKDEEISNLHQRLSEFPH---FRNNHKTARTF-------DTVK--TKD 163
Query: 253 IFTTQDELLVYNKNQHQTK-NLSQDQEHGRKAHKISYPSS-RTEERQLHHGEKSVQKDVS 310
+ + L +K H+ K ++S+D H + +++R H SV+K +
Sbjct: 164 LKSRSPHLDDCSKTDHRAKSDVSKDVHHSTSLPNLEKEGKPHSDKRSTSHLPTSVEKHCT 223
Query: 311 KGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSSTEERHLNCGEKGIQKGVS 370
G S + G S ++D G K+ + S + TE K + G
Sbjct: 224 NGVWSRSHYQVGEGSS-------NEDSRRGRKDIRHSQFNRGTER-----VRKDLSTGCG 271
Query: 371 KGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTE---------ERRLNSG 421
G I Q R+ ++YG E K +SS + ER +S
Sbjct: 272 DGEPRILEASQ---------RLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSW 322
Query: 422 EKDVQKGVSKGSISIQTEEKIHGKSQ-----NQVTIPSQDQEH----------------- 459
EK+ S + Q+++K+ +S+ N+ + SQD+E
Sbjct: 323 EKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHW 382
Query: 460 --------GHKENKMSYQSSST----EERRLNYGGKSTQKDVSQSSISFQIEKLVEGKSQ 507
H +N++++ +S+ EERR G + ++D S +S SFQ + S
Sbjct: 383 RRSERASLPHSKNEITFSHNSSKYHLEERR---GWEDCKRDKSVNSHSFQDGRCPSSLSN 439
Query: 508 IQTPNPNQD--------QWSGQNAKGKSGQSADSKQDLLSHEQKGRYKQESSESHNIVIT 559
+T + N D QW K + ++ D ++ EQ+ + + + V T
Sbjct: 440 SRT-HKNIDSKEVDAMHQWENTPLKAERHRTEDKRK----REQESKEENRHIRNEKRVPT 494
Query: 560 EH 561
EH
Sbjct: 495 EH 496
Score = 39.7 bits (91), Expect = 0.008
Identities = 92/436 (21%), Positives = 164/436 (37%), Gaps = 82/436 (18%)
Query: 37 SQFPHGQKGQHYFGQKDQQHTKSKGSFSIQHTYHVDINDHDWTRKSQQYDLNALHKATKS 96
S+FPH + D TK S S H+D + D A +K
Sbjct: 141 SEFPHFRNNHKTARTFDTVKTKDLKSRSP----HLD--------DCSKTDHRAKSDVSKD 188
Query: 97 KQHLGGSQQLLNYKQEGRDHDKSKGHFHM---IVIHHKGG-------QAHHGTQNPSQ-- 144
H S L N ++EG+ H + H+ + H G Q G+ N
Sbjct: 189 VHH---STSLPNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSNEDSRR 245
Query: 145 ----------DQGNSPSGKGLSSQCSNTEKRLWVHGLSKEQASASGAQKGRTQGGSQSSY 194
++G K LS+ C + E R+ + + Q KG + S+SS
Sbjct: 246 GRKDIRHSQFNRGTERVRKDLSTGCGDGEPRI-LEASQRLQGHPEKYGKGEPKTESKSSK 304
Query: 195 VLQTEELVVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHPAHQDRLQHGPKDIF 254
+ ++ + + G + V + KL+ +R Q+ +
Sbjct: 305 FKSNSDSDYKGERINSSWEKETPGERSHS-RVDSQSDKKLERQ-----SERSQNINRKEV 358
Query: 255 TTQDELLVYNKNQHQTKNLSQDQEHGRKAHKISYPSSRTEERQLHHGEK----------S 304
+QD+ K + K++ +DQ+H R++ + S P S+ E H+ K
Sbjct: 359 KSQDK--EERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWED 416
Query: 305 VQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSST---EERHLNCG 361
++D S S S Q G+ + ++ + KE +Q +T ERH
Sbjct: 417 CKRDKSVNSHSFQ-----DGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERH-RTE 470
Query: 362 EKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEERRLNSG 421
+K ++ SK EE H +N+ R+P++ + +KE K ++T+ ++ N
Sbjct: 471 DKRKREQESK-------EENRH--IRNEKRVPTEHLQKTNKETK----KTTTDLKKQNEP 517
Query: 422 EKD----VQKGVSKGS 433
+ D + GVS+G+
Sbjct: 518 KTDKGEVLDNGVSEGA 533
>gi|6912288 caspase 8 associated protein 2 [Homo sapiens]
Length = 1982
Score = 50.4 bits (119), Expect = 4e-06
Identities = 88/422 (20%), Positives = 160/422 (37%), Gaps = 94/422 (22%)
Query: 193 SYVLQTEELVVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHPAHQDRLQHGPKD 252
S +++T + +N++ E N HQ + + R H + D ++ KD
Sbjct: 116 SALIKTARVEINRKDEEISNLHQRLSEFPH---FRNNHKTARTF-------DTVK--TKD 163
Query: 253 IFTTQDELLVYNKNQHQTK-NLSQDQEHGRKAHKISYPSS-RTEERQLHHGEKSVQKDVS 310
+ + L +K H+ K ++S+D H + +++R H SV+K +
Sbjct: 164 LKSRSPHLDDCSKTDHRAKSDVSKDVHHSTSLPNLEKEGKPHSDKRSTSHLPTSVEKHCT 223
Query: 311 KGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSSTEERHLNCGEKGIQKGVS 370
G S + G S ++D G K+ + S + TE K + G
Sbjct: 224 NGVWSRSHYQVGEGSS-------NEDSRRGRKDIRHSQFNRGTER-----VRKDLSTGCG 271
Query: 371 KGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTE---------ERRLNSG 421
G I Q R+ ++YG E K +SS + ER +S
Sbjct: 272 DGEPRILEASQ---------RLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSW 322
Query: 422 EKDVQKGVSKGSISIQTEEKIHGKSQ-----NQVTIPSQDQEH----------------- 459
EK+ S + Q+++K+ +S+ N+ + SQD+E
Sbjct: 323 EKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHW 382
Query: 460 --------GHKENKMSYQSSST----EERRLNYGGKSTQKDVSQSSISFQIEKLVEGKSQ 507
H +N++++ +S+ EERR G + ++D S +S SFQ + S
Sbjct: 383 RRSERASLPHSKNEITFSHNSSKYHLEERR---GWEDCKRDKSVNSHSFQDGRCPSSLSN 439
Query: 508 IQTPNPNQD--------QWSGQNAKGKSGQSADSKQDLLSHEQKGRYKQESSESHNIVIT 559
+T + N D QW K + ++ D ++ EQ+ + + + V T
Sbjct: 440 SRT-HKNIDSKEVDAMHQWENTPLKAERHRTEDKRK----REQESKEENRHIRNEKRVPT 494
Query: 560 EH 561
EH
Sbjct: 495 EH 496
Score = 39.7 bits (91), Expect = 0.008
Identities = 92/436 (21%), Positives = 164/436 (37%), Gaps = 82/436 (18%)
Query: 37 SQFPHGQKGQHYFGQKDQQHTKSKGSFSIQHTYHVDINDHDWTRKSQQYDLNALHKATKS 96
S+FPH + D TK S S H+D + D A +K
Sbjct: 141 SEFPHFRNNHKTARTFDTVKTKDLKSRSP----HLD--------DCSKTDHRAKSDVSKD 188
Query: 97 KQHLGGSQQLLNYKQEGRDHDKSKGHFHM---IVIHHKGG-------QAHHGTQNPSQ-- 144
H S L N ++EG+ H + H+ + H G Q G+ N
Sbjct: 189 VHH---STSLPNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSNEDSRR 245
Query: 145 ----------DQGNSPSGKGLSSQCSNTEKRLWVHGLSKEQASASGAQKGRTQGGSQSSY 194
++G K LS+ C + E R+ + + Q KG + S+SS
Sbjct: 246 GRKDIRHSQFNRGTERVRKDLSTGCGDGEPRI-LEASQRLQGHPEKYGKGEPKTESKSSK 304
Query: 195 VLQTEELVVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHPAHQDRLQHGPKDIF 254
+ ++ + + G + V + KL+ +R Q+ +
Sbjct: 305 FKSNSDSDYKGERINSSWEKETPGERSHS-RVDSQSDKKLERQ-----SERSQNINRKEV 358
Query: 255 TTQDELLVYNKNQHQTKNLSQDQEHGRKAHKISYPSSRTEERQLHHGEK----------S 304
+QD+ K + K++ +DQ+H R++ + S P S+ E H+ K
Sbjct: 359 KSQDK--EERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWED 416
Query: 305 VQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSST---EERHLNCG 361
++D S S S Q G+ + ++ + KE +Q +T ERH
Sbjct: 417 CKRDKSVNSHSFQ-----DGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERH-RTE 470
Query: 362 EKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEERRLNSG 421
+K ++ SK EE H +N+ R+P++ + +KE K ++T+ ++ N
Sbjct: 471 DKRKREQESK-------EENRH--IRNEKRVPTEHLQKTNKETK----KTTTDLKKQNEP 517
Query: 422 EKD----VQKGVSKGS 433
+ D + GVS+G+
Sbjct: 518 KTDKGEVLDNGVSEGA 533
>gi|212549532 caspase 8 associated protein 2 [Homo sapiens]
Length = 1982
Score = 50.4 bits (119), Expect = 4e-06
Identities = 88/422 (20%), Positives = 160/422 (37%), Gaps = 94/422 (22%)
Query: 193 SYVLQTEELVVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHPAHQDRLQHGPKD 252
S +++T + +N++ E N HQ + + R H + D ++ KD
Sbjct: 116 SALIKTARVEINRKDEEISNLHQRLSEFPH---FRNNHKTARTF-------DTVK--TKD 163
Query: 253 IFTTQDELLVYNKNQHQTK-NLSQDQEHGRKAHKISYPSS-RTEERQLHHGEKSVQKDVS 310
+ + L +K H+ K ++S+D H + +++R H SV+K +
Sbjct: 164 LKSRSPHLDDCSKTDHRAKSDVSKDVHHSTSLPNLEKEGKPHSDKRSTSHLPTSVEKHCT 223
Query: 311 KGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSSTEERHLNCGEKGIQKGVS 370
G S + G S ++D G K+ + S + TE K + G
Sbjct: 224 NGVWSRSHYQVGEGSS-------NEDSRRGRKDIRHSQFNRGTER-----VRKDLSTGCG 271
Query: 371 KGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTE---------ERRLNSG 421
G I Q R+ ++YG E K +SS + ER +S
Sbjct: 272 DGEPRILEASQ---------RLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSW 322
Query: 422 EKDVQKGVSKGSISIQTEEKIHGKSQ-----NQVTIPSQDQEH----------------- 459
EK+ S + Q+++K+ +S+ N+ + SQD+E
Sbjct: 323 EKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHW 382
Query: 460 --------GHKENKMSYQSSST----EERRLNYGGKSTQKDVSQSSISFQIEKLVEGKSQ 507
H +N++++ +S+ EERR G + ++D S +S SFQ + S
Sbjct: 383 RRSERASLPHSKNEITFSHNSSKYHLEERR---GWEDCKRDKSVNSHSFQDGRCPSSLSN 439
Query: 508 IQTPNPNQD--------QWSGQNAKGKSGQSADSKQDLLSHEQKGRYKQESSESHNIVIT 559
+T + N D QW K + ++ D ++ EQ+ + + + V T
Sbjct: 440 SRT-HKNIDSKEVDAMHQWENTPLKAERHRTEDKRK----REQESKEENRHIRNEKRVPT 494
Query: 560 EH 561
EH
Sbjct: 495 EH 496
Score = 39.7 bits (91), Expect = 0.008
Identities = 92/436 (21%), Positives = 164/436 (37%), Gaps = 82/436 (18%)
Query: 37 SQFPHGQKGQHYFGQKDQQHTKSKGSFSIQHTYHVDINDHDWTRKSQQYDLNALHKATKS 96
S+FPH + D TK S S H+D + D A +K
Sbjct: 141 SEFPHFRNNHKTARTFDTVKTKDLKSRSP----HLD--------DCSKTDHRAKSDVSKD 188
Query: 97 KQHLGGSQQLLNYKQEGRDHDKSKGHFHM---IVIHHKGG-------QAHHGTQNPSQ-- 144
H S L N ++EG+ H + H+ + H G Q G+ N
Sbjct: 189 VHH---STSLPNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSNEDSRR 245
Query: 145 ----------DQGNSPSGKGLSSQCSNTEKRLWVHGLSKEQASASGAQKGRTQGGSQSSY 194
++G K LS+ C + E R+ + + Q KG + S+SS
Sbjct: 246 GRKDIRHSQFNRGTERVRKDLSTGCGDGEPRI-LEASQRLQGHPEKYGKGEPKTESKSSK 304
Query: 195 VLQTEELVVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHPAHQDRLQHGPKDIF 254
+ ++ + + G + V + KL+ +R Q+ +
Sbjct: 305 FKSNSDSDYKGERINSSWEKETPGERSHS-RVDSQSDKKLERQ-----SERSQNINRKEV 358
Query: 255 TTQDELLVYNKNQHQTKNLSQDQEHGRKAHKISYPSSRTEERQLHHGEK----------S 304
+QD+ K + K++ +DQ+H R++ + S P S+ E H+ K
Sbjct: 359 KSQDK--EERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWED 416
Query: 305 VQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSST---EERHLNCG 361
++D S S S Q G+ + ++ + KE +Q +T ERH
Sbjct: 417 CKRDKSVNSHSFQ-----DGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERH-RTE 470
Query: 362 EKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEERRLNSG 421
+K ++ SK EE H +N+ R+P++ + +KE K ++T+ ++ N
Sbjct: 471 DKRKREQESK-------EENRH--IRNEKRVPTEHLQKTNKETK----KTTTDLKKQNEP 517
Query: 422 EKD----VQKGVSKGS 433
+ D + GVS+G+
Sbjct: 518 KTDKGEVLDNGVSEGA 533
>gi|57864582 hornerin [Homo sapiens]
Length = 2850
Score = 50.1 bits (118), Expect = 6e-06
Identities = 125/576 (21%), Positives = 193/576 (33%), Gaps = 77/576 (13%)
Query: 25 KGGSKGQLPSGSSQFP-HGQKGQ----------HYFGQKD----QQHTKSKGSFSIQHTY 69
+ +GQ SGS Q P +GQ G H G QH S G S ++
Sbjct: 188 QSSGRGQCGSGSGQSPNYGQHGSGSGQSSSNDTHGSGSGQSSGFSQHKSSSGQ-SSGYSQ 246
Query: 70 HVDINDH-----DWTRKSQQYDLNALHKATKSK-----QHLGGSQQLLNYKQEGRDHDKS 119
H + H +S Q H+++ QH GS+Q L + ++G +S
Sbjct: 247 HGSGSGHSSGYGQHGSRSGQSSRGERHRSSSGSSSSYGQHGSGSRQSLGHGRQGSGSRQS 306
Query: 120 KGHF-HMIVIHHKGGQAHHGT-QNPSQDQGNSPSGKGLSSQCSNTEKRLWVHGLSKEQAS 177
H H H HG+ + S +G+ SG G +S E + S
Sbjct: 307 PSHVRHGSGSGHSSSHGQHGSGSSYSYSRGHYESGSGQTSGFGQHESGSGQSSGYSKHGS 366
Query: 178 ASGAQKGRTQGGSQSSYVLQTEELVVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTS 237
SG + Q GS S + + + +Q + H++ + + R +HSS S
Sbjct: 367 GSGHSSSQGQHGSTSGQASSSGQHGSSSRQSSSYGQHESASRHSS---GRGQHSSGSGQS 423
Query: 238 LHPAHQDRLQHGPKDIFTTQDELLVYNKNQHQTKNLSQDQEHGRKAHKISYPSSRTEERQ 297
P H R + + QH T GR + Y S
Sbjct: 424 --PGHGQRGSGSGQS----------PSSGQHGT-------GFGRSSSSGPYVSGSGYSSG 464
Query: 298 LHHGEKSVQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSSTEERH 357
H E S S+ S G S S+ + E + S SS+
Sbjct: 465 FGHHESS-----SEHSSGYTQHGSGSGHSSGHGQHGSRSGQSSRGERQGSSAGSSSSYGQ 519
Query: 358 LNCGEKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKIS----YQSSST 413
G + GS S Q+ G+ ++ R S +G+ + S Y+S S
Sbjct: 520 HGSGSRQSLGHSRHGSGSGQSPSPSRGRHESGSRQSSSYGPHGYGSGRSSSRGPYESGSG 579
Query: 414 EERRLNSGEKDVQKGVSKG---SISIQTEEKIHGKSQNQVTIPSQDQEHGHKENKMS--- 467
L G ++ + G S G S HG+ + S +HG + S
Sbjct: 580 HSSGL--GHQESRSGQSSGYGQHGSSSGHSSTHGQHGSTSGQSSSCGQHGATSGQSSSHG 637
Query: 468 -YQSSSTEERRLNYGGKSTQKDVSQS--------SISFQIEKLVEGKSQIQTPNPN-QDQ 517
+ S S++ R G + + S+ S S+ G S P+ + Q
Sbjct: 638 QHGSGSSQSSRYGQQGSGSGQSPSRGRHGSDFGHSSSYGQHGSGSGWSSSNGPHGSVSGQ 697
Query: 518 WSGQNAKGKSGQSADSKQDLLSHEQKGRYKQESSES 553
SG K SGQS+ Q Y++ S S
Sbjct: 698 SSGFGHKSGSGQSSGYSQHGSGSSHSSGYRKHGSRS 733
Score = 48.5 bits (114), Expect = 2e-05
Identities = 131/603 (21%), Positives = 195/603 (32%), Gaps = 102/603 (16%)
Query: 17 KQAAVMGQKGGSKGQLPS------------GSSQFPHGQ-------KGQHYFGQKDQQ-- 55
+Q+ GQ G GQ PS SS P+G +G + G
Sbjct: 1461 RQSLGHGQHGSGSGQSPSPSRGRHGSGSGQSSSYSPYGSGSGWSSSRGPYESGSSHSSGL 1520
Query: 56 -HTKSKGSFSIQHTYHVDINDHDWTR-----KSQQYDLNALHKATKSK-----QHLGGSQ 104
H +S+ S + H + H T S Q H A+ + QH GS
Sbjct: 1521 GHRESRSGQSSGYGQHGSSSGHSSTHGQHGSTSGQSSSCGQHGASSGQSSSHGQHGSGSS 1580
Query: 105 QLLNYKQEGRDHDKSKGHFHM-IVIHHKGGQAHHGT-QNPSQDQGNSPSGKGLSSQCSNT 162
Q Y ++G +S GH HG+ S G SG G SS +
Sbjct: 1581 QSSGYGRQGSGSGQSPGHGQRGSGSRQSPSYGRHGSGSGRSSSSGQHGSGLGESSGFGHH 1640
Query: 163 EKRLWVHGLSKEQASASGAQKGRTQGGSQSSYVLQTEELVVNKQQRETKNSH-----QNK 217
E + S SG G Q GS+S + E + + H Q+
Sbjct: 1641 ESSSGQSSSYSQHGSGSGHSSGYGQHGSRSGQSSRGERHGSSSRSSSRYGQHGSGSRQSS 1700
Query: 218 GHYQ-----NVVDVREEHSSKL-QTSLHPAHQD----RLQHGPKDIFTTQDELLVYNKNQ 267
GH + R H S L +S H H GP + + V+ +++
Sbjct: 1701 GHGRQGSGSGQSPSRGRHGSGLGHSSSHGQHGSGSGRSSSRGPYE--SRSGHSSVFGQHE 1758
Query: 268 HQTKNLSQDQEHGR-KAHKISYPSSRTEERQLHHGEKSVQK---DVSKGSISIQTEEKIH 323
+ + S +HG H S Q HG S Q D S + H
Sbjct: 1759 SGSGHSSAYSQHGSGSGHFCS---------QGQHGSTSGQSSTFDQEGSSTGQSSSHGQH 1809
Query: 324 GKSQNQVTIHSQDQEHGHKENKISYQSSSTEERHLNCGEKGIQKGVSKGSISIQTEEQIH 383
G +Q + + Q Q G ++ + S + G+ G G S S H
Sbjct: 1810 GSGSSQSSSYGQ-QGSGSGQSPSRGRHGSGSGHSSSYGQHGSGSGWSSSS-------GRH 1861
Query: 384 GKSQNQVRIPSQAQEYGHKENKISYQSSSTEERRLNSGEKDVQKGVSKGSISIQTEEKIH 443
G Q+ +GH E+ S+QSS + SG + + H
Sbjct: 1862 GSGS------GQSSGFGHHESS-SWQSSGYTQHGSGSGH--------------SSSYEQH 1900
Query: 444 GKSQNQVTIPSQDQEHGHKENKMSY--QSSSTEERRLNYGGKSTQKDVSQSSISFQIEKL 501
G Q S+ ++HG S Q S + L +G + S S S
Sbjct: 1901 GSRSGQ---SSRGEQHGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSP-SRGRHGS 1956
Query: 502 VEGKSQIQTPNPNQDQWSGQNAKGKSGQSADS---KQDLLSHEQKGRYKQESSESHNIVI 558
G+S P + WS +SG S ++ S + G + SS H+
Sbjct: 1957 GSGQSSSYGPYGSGSGWSSSRGPYESGSGHSSGLGHRESRSGQSSGYGQHGSSSGHSSTH 2016
Query: 559 TEH 561
+H
Sbjct: 2017 GQH 2019
Score = 46.6 bits (109), Expect = 6e-05
Identities = 130/573 (22%), Positives = 189/573 (32%), Gaps = 79/573 (13%)
Query: 23 GQKGGSKGQLPSGSSQFP----HGQKGQHYFGQKDQQHTKSKGSFSIQHTYHVDINDHDW 78
GQ G GQ SGS Q HG H Q T + S S QH
Sbjct: 343 GQTSGF-GQHESGSGQSSGYSKHGSGSGHSSSQGQHGSTSGQASSSGQHGSS-------- 393
Query: 79 TRKSQQYDLN--ALHKATKSKQHLGGSQQLLNYKQEGRDHDKSKGHFHMIVIHHKGGQAH 136
+R+S Y + A ++ QH GS Q + Q G +S
Sbjct: 394 SRQSSSYGQHESASRHSSGRGQHSSGSGQSPGHGQRGSGSGQSPS------------SGQ 441
Query: 137 HGTQ-NPSQDQGNSPSGKGLSSQCSNTEKRLWVHGLSKEQASASGAQKGRTQGGSQSSYV 195
HGT S G SG G SS + E + S SG G Q GS+S
Sbjct: 442 HGTGFGRSSSSGPYVSGSGYSSGFGHHESSSEHSSGYTQHGSGSGHSSGHGQHGSRSGQS 501
Query: 196 LQTEELVVNKQQRETKNSH-----QNKGHY-------QNVVDVREEHSS-KLQTSLHPAH 242
+ E + + H Q+ GH Q+ R H S Q+S + H
Sbjct: 502 SRGERQGSSAGSSSSYGQHGSGSRQSLGHSRHGSGSGQSPSPSRGRHESGSRQSSSYGPH 561
Query: 243 Q----DRLQHGPKDIFTTQDELLVYNKNQHQTKNLSQDQEHGRKAHKISYPSSRTEERQL 298
GP + + L HQ Q +G+ + S+ +
Sbjct: 562 GYGSGRSSSRGPYESGSGHSSGL-----GHQESRSGQSSGYGQHGSSSGHSSTHGQ---- 612
Query: 299 HHGEKSVQKDV--SKGSISIQTEEK-IHGKSQNQVTIHSQDQEHGHKENKISYQSSSTEE 355
HG S Q G+ S Q+ HG +Q + + Q Q G ++ + S
Sbjct: 613 -HGSTSGQSSSCGQHGATSGQSSSHGQHGSGSSQSSRYGQ-QGSGSGQSPSRGRHGSDFG 670
Query: 356 RHLNCGEKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEE 415
+ G+ G G S + + G+S Q G+ ++ SS
Sbjct: 671 HSSSYGQHGSGSGWSSSN---GPHGSVSGQSSGFGHKSGSGQSSGYSQHGSGSSHSSGYR 727
Query: 416 R---RLNSGEKDVQKGVSKGSISIQTEEKIHGKSQNQVTIPS-QDQEHGHKENKMSYQSS 471
+ R + Q G S G S + HG +Q + Q GH +++ + SS
Sbjct: 728 KHGSRSGQSSRSEQHGSSSGLSSSYGQ---HGSGSHQSSGHGRQGSGSGHSPSRVRHGSS 784
Query: 472 STEERRLNYGGKSTQ--------KDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQNA 523
S G T + S + F + G+ Q + + +S Q
Sbjct: 785 SGHSSSHGQHGSGTSCSSSCGHYESGSGQASGFGQHESGSGQGYSQHGSAS-GHFSSQGR 843
Query: 524 KGK-SGQSADSKQDLLSHEQKGRYKQESSESHN 555
G SGQS+ S Q S Q Y Q S SH+
Sbjct: 844 HGSTSGQSSSSGQHDSSSGQSSSYGQHESASHH 876
Score = 46.2 bits (108), Expect = 8e-05
Identities = 122/551 (22%), Positives = 174/551 (31%), Gaps = 98/551 (17%)
Query: 23 GQKGGSKGQLP----SGSSQFPHGQKGQHYFGQKDQQHTKSKGSFSIQHTYHVDINDHDW 78
GQ G GQ GSS GQH G + GS S Q
Sbjct: 492 GQHGSRSGQSSRGERQGSSAGSSSSYGQHGSGSRQSLGHSRHGSGSGQSPSPSRGRHESG 551
Query: 79 TRKSQQYDLNALHKATKSKQHLGGSQQLLNYKQEGRDHDKSKGHFHMIVIHHKGGQAHHG 138
+R+S Y + S + + G H GH G H
Sbjct: 552 SRQSSSYGPHGYGSGRSSSR---------GPYESGSGHSSGLGHQESRSGQSSGYGQHGS 602
Query: 139 TQNPSQDQGNSPSGKGLSSQCSNTEKRLWVHGLSKEQASASGAQKGRTQGGSQSSYVLQT 198
+ S G S G SS C HG + Q+S+ G Q GS SS +
Sbjct: 603 SSGHSSTHGQHGSTSGQSSSCGQ-------HGATSGQSSSHG------QHGSGSSQSSRY 649
Query: 199 EELVVNKQQRETKNSHQNK-GHYQNVVDVREEHSSKLQTSLHPAHQDRLQHGPKDIFTTQ 257
+ Q ++ H + GH + +H S S +GP + Q
Sbjct: 650 GQQGSGSGQSPSRGRHGSDFGHSSSY----GQHGSGSGWSS--------SNGPHGSVSGQ 697
Query: 258 DELLVYNKNQHQTKNLSQDQEHGR-KAHKISYPSSRTEERQLHHGEKSVQKDVSK---GS 313
+ Q+ SQ HG +H Y HG +S Q S+ S
Sbjct: 698 SSGFGHKSGSGQSSGYSQ---HGSGSSHSSGYRK---------HGSRSGQSSRSEQHGSS 745
Query: 314 ISIQTEEKIHGKSQNQVTIHS-QDQEHGHKENKISYQSSSTEERHLNCGEKGIQKGVSKG 372
+ + HG +Q + H Q GH +++ + SSS
Sbjct: 746 SGLSSSYGQHGSGSHQSSGHGRQGSGSGHSPSRVRHGSSSGHSSS--------------- 790
Query: 373 SISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEERRLNSGEKDVQKGVSKG 432
HG+ + S GH E+ S Q+S + SG+ Q G + G
Sbjct: 791 ----------HGQHGSGTSCSSSC---GHYESG-SGQASGFGQHESGSGQGYSQHGSASG 836
Query: 433 SISIQTEEKIHGKSQNQVTIPSQ-DQEHGHKENKMSYQSSSTEER-RLNYGGKSTQK--- 487
S Q HG + Q + Q D G + ++S+S R +G S Q
Sbjct: 837 HFSSQGR---HGSTSGQSSSSGQHDSSSGQSSSYGQHESASHHASGRGRHGSGSGQSPGH 893
Query: 488 ----DVSQSSISFQIEKLVEGKSQIQTPNPN-QDQWSGQNAKGKSGQSADSKQDLLSHEQ 542
S S S+ G+S + + Q SG K SGQS+ Q
Sbjct: 894 GQRGSGSGQSPSYGRHGSGSGRSSSSGRHGSGSGQSSGFGHKSSSGQSSGYTQHGSGSGH 953
Query: 543 KGRYKQESSES 553
Y+Q S S
Sbjct: 954 SSSYEQHGSRS 964
Score = 45.1 bits (105), Expect = 2e-04
Identities = 129/591 (21%), Positives = 196/591 (33%), Gaps = 105/591 (17%)
Query: 23 GQKGGSKGQLPS----------GSSQFPHGQKGQHYFGQKDQQHTKSKGSFSIQHTYHVD 72
G+ G GQ S SS+ P+ H G H +S+ S + H
Sbjct: 1012 GRHGSGSGQSSSYGPYRSGSGWSSSRGPYESGSGHSSGLG---HRESRSGQSSGYGQHGS 1068
Query: 73 INDHDWTR-----KSQQYDLNALHKATKSK-----QHLGGSQQLLNYKQEGRDHDKSKGH 122
+ H T S Q H A+ + QH GS Q Y ++G +S GH
Sbjct: 1069 SSGHSSTHGQHGSTSGQSSSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQGSGSGQSPGH 1128
Query: 123 FHMIVIHHKGGQAHHGTQNPSQDQGNSPSGKGLSSQCSNT---EKRLWVHGLSKEQASAS 179
G + Q+PS + S SG+ SS + E + H S S+S
Sbjct: 1129 ---------GQRGSGSRQSPSYGRHGSGSGRSSSSGQHGSGLGESSGFGHHESSSGQSSS 1179
Query: 180 GAQKGRTQGGSQSSYVLQTEELVVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLH 239
+Q G G S S Y + + +S + HY + S Q+S H
Sbjct: 1180 YSQHGSGSGHS-SGYGQHGSRSGQSSRGERHGSSSGSSSHY------GQHGSGSRQSSGH 1232
Query: 240 PAHQDRLQHGPKDIFTTQDELLVYNKNQHQTKNLSQDQEHGRKAHKISYPSSR-TEERQL 298
H P ++ +H + L HG+ SSR E +
Sbjct: 1233 GRQGSGSGHSP-------------SRGRHGS-GLGHSSSHGQHGSGSGRSSSRGPYESRS 1278
Query: 299 HHGEKSVQKDVSKGSISIQTE----------EKIHGKSQNQVTIHSQD-------QEHGH 341
H Q + G S ++ + HG + Q + Q+ +GH
Sbjct: 1279 GHSSVFGQHESGSGHSSAYSQHGSGSGHFCSQGQHGSTSGQSSTFDQEGSSTGQSSSYGH 1338
Query: 342 KENKISYQSSSTEERHLNCGE---KGIQKGVSKGSISIQTEEQIHGKSQNQVRIPS---Q 395
+ + S QSS G+ +G S S S G S + R S Q
Sbjct: 1339 RGSG-SSQSSGYGRHGAGSGQSPSRGRHGSGSGHSSSYGQHGSGSGWSSSSGRHGSGSGQ 1397
Query: 396 AQEYGHKENKISYQSSSTEERRLNSGEKDVQKGVSKGSISIQTEEKIHGKSQNQVTIPSQ 455
+ +GH E+ S+QSS + SG + + HG Q S+
Sbjct: 1398 SSGFGHHESS-SWQSSGCTQHGSGSGH--------------SSSYEQHGSRSGQ---SSR 1439
Query: 456 DQEHGHKENKMSY--QSSSTEERRLNYGGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNP 513
+ HG S Q S + L +G + S S S G+S +P
Sbjct: 1440 GERHGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSP-SRGRHGSGSGQSSSYSPYG 1498
Query: 514 NQDQWSGQNAKGKSGQSADS---KQDLLSHEQKGRYKQESSESHNIVITEH 561
+ WS +SG S S ++ S + G + SS H+ +H
Sbjct: 1499 SGSGWSSSRGPYESGSSHSSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQH 1549
Score = 44.3 bits (103), Expect = 3e-04
Identities = 130/601 (21%), Positives = 204/601 (33%), Gaps = 98/601 (16%)
Query: 17 KQAAVMGQKGGSKGQLPS------------GSSQFPHGQ-------KGQHYFGQKDQQ-- 55
+Q+ GQ G GQ PS SS P+G +G + G
Sbjct: 1931 RQSLGHGQHGSGSGQSPSPSRGRHGSGSGQSSSYGPYGSGSGWSSSRGPYESGSGHSSGL 1990
Query: 56 -HTKSKGSFSIQHTYHVDINDHDWTR-----KSQQYDLNALHKATKSK-----QHLGGSQ 104
H +S+ S + H + H T S Q H A+ + QH GS
Sbjct: 1991 GHRESRSGQSSGYGQHGSSSGHSSTHGQHGSASGQSSSCGQHGASSGQSSSHGQHGSGSS 2050
Query: 105 QLLNYKQEGRDHDKSKGHFHMIVIHHKGGQAHHGTQNPSQDQGNSPSGKGLSSQCSNT-- 162
Q Y ++G +S GH G + Q+PS + S SG+ SS
Sbjct: 2051 QSSGYGRQGSGSGQSPGH---------GQRGSGSRQSPSYGRHGSGSGRSSSSGQHGPGL 2101
Query: 163 -EKRLWVHGLSKEQASASGAQKGRTQGGSQSSYVLQTEELVVNKQQRETKNSHQNKGHYQ 221
E + H S S+S +Q G G S + ++ +R +S + + Q
Sbjct: 2102 GESSGFGHHESSSGQSSSYSQHGSGSGHSSGYGQHGSRSGQSSRGERHGSSSGSSSRYGQ 2161
Query: 222 NVVDVREEHSSKLQTSLHPAHQDRLQHGPKDIFTTQDELLVYNKNQHQT---KNLSQDQE 278
+ R+ Q S R +HG ++ + QH + ++ S+
Sbjct: 2162 HGSGSRQSSGHGRQGSGSGHSPSRGRHGSGSGHSS-------SHGQHGSGSGRSSSRGPY 2214
Query: 279 HGRKAHKISYPSSRTEERQLHHGEKSVQKDVSKGSISIQTEEKIHGKSQNQVTIHSQD-- 336
R H SS + + G S GS ++ + HG + Q + Q+
Sbjct: 2215 ESRSGH-----SSVFGQHESGSGHSSAYSQHGSGSGHFCSQGQ-HGSTSGQSSTFDQEGS 2268
Query: 337 -----QEHGHKENKISYQSSSTEERHLNCGE---KGIQKGVSKGSISIQTEEQIHGKSQN 388
HG + S QSSS ++ G+ +G S S S G S +
Sbjct: 2269 STGQSSSHG-QHGSGSSQSSSYGQQGSGSGQSPSRGRHGSGSGHSSSYGQHGSGSGWSSS 2327
Query: 389 QVRIPS---QAQEYGHKENKISYQSSSTEERRLNSGEKDVQKGVSKGSISIQTEEKIHGK 445
R S Q+ +GH E+ S+QSS + SG + + HG
Sbjct: 2328 SGRHGSGSGQSSGFGHHESS-SWQSSGYTQHGSGSGH--------------SSSYEQHGS 2372
Query: 446 SQNQVTIPSQDQEHGHKENKMSY--QSSSTEERRLNYGGKSTQKDVSQSSISFQIEKLVE 503
Q S+ + HG S Q S + L +G + S S S
Sbjct: 2373 RSGQ---SSRGERHGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSP-SRGRHGSGS 2428
Query: 504 GKSQIQTPNPNQDQWSGQNAKGKSGQSADS---KQDLLSHEQKGRYKQESSESHNIVITE 560
G+S +P + WS +SG S ++ S + G + SS H+ +
Sbjct: 2429 GQSSSYSPYGSGSGWSSSRGPYESGSGHSSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQ 2488
Query: 561 H 561
H
Sbjct: 2489 H 2489
Score = 42.7 bits (99), Expect = 0.001
Identities = 119/585 (20%), Positives = 187/585 (31%), Gaps = 72/585 (12%)
Query: 23 GQKGGSKGQLPS----GSSQFPHGQKGQHYFGQKDQQ---HTKSKGSFSIQHTYHVDIND 75
GQ+G GQ PS GS G+H G H S G S +T H +
Sbjct: 894 GQRGSGSGQSPSYGRHGSGSGRSSSSGRHGSGSGQSSGFGHKSSSGQSS-GYTQHGSGSG 952
Query: 76 HDWTRKSQQYDLNALHKATKSKQHLGGSQQLLNYKQEGRDHDKSKGHFH----------M 125
H S + + ++++S+QH S +Y Q G +S GH
Sbjct: 953 HS---SSYEQHGSRSGQSSRSEQHGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSP 1009
Query: 126 IVIHHKGGQAHHGTQNP-------SQDQGNSPSGKGLSSQCSNTEKR------LWVHGLS 172
H G + P S +G SG G SS + E R HG S
Sbjct: 1010 SRGRHGSGSGQSSSYGPYRSGSGWSSSRGPYESGSGHSSGLGHRESRSGQSSGYGQHGSS 1069
Query: 173 KEQASASG------------AQKGRTQGGSQSSYVLQTEELVVNKQQRETKNSHQNKGHY 220
+S G Q G + G S S + + R+ S Q+ GH
Sbjct: 1070 SGHSSTHGQHGSTSGQSSSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQGSGSGQSPGHG 1129
Query: 221 QNVVDVREEHSSKLQTSLHPAHQDRLQHGPKDIFTTQDELLVYNKNQHQTKNLSQDQEHG 280
Q R+ S S QHG + E + ++ + S +HG
Sbjct: 1130 QRGSGSRQSPSYGRHGSGSGRSSSSGQHG-----SGLGESSGFGHHESSSGQSSSYSQHG 1184
Query: 281 R-KAHKISYPSSRTEERQLHHGEKSVQKDVSKGSISIQTEEKIHGKSQNQVTIHS-QDQE 338
H Y + Q GE+ S GS S + HG Q + H Q
Sbjct: 1185 SGSGHSSGYGQHGSRSGQSSRGER---HGSSSGSSSHYGQ---HGSGSRQSSGHGRQGSG 1238
Query: 339 HGHKENKISYQSSSTEERHLNCGEKGIQKGVSKGSISIQT-EEQIHGKSQNQVRIPSQAQ 397
GH ++ + S G + S+G ++ + G+ ++ S
Sbjct: 1239 SGHSPSRGRHGSGLGHSSSHGQHGSGSGRSSSRGPYESRSGHSSVFGQHESGSGHSSAYS 1298
Query: 398 EYGH---------KENKISYQSSSTEERRLNSGEKDVQKGVSKGSISIQTEEKIHGKSQN 448
++G + S QSS+ ++ ++G+ GS S + HG
Sbjct: 1299 QHGSGSGHFCSQGQHGSTSGQSSTFDQEGSSTGQSSSYGHRGSGS-SQSSGYGRHGAGSG 1357
Query: 449 QVTIPSQDQEHGHKENKMSYQSSSTEERRLNYGGKSTQKDVSQSSISFQIEKLVEGKSQI 508
Q PS+ + + SY + + G+ S +
Sbjct: 1358 Q--SPSRGRHGSGSGHSSSYGQHGSGSGWSSSSGRHGSGSGQSSGFGHHESSSWQSSGCT 1415
Query: 509 QTPNPNQDQWSGQNAKGKSGQSADSKQDLLSHEQKGRYKQESSES 553
Q + + S + +SGQS+ ++ S Y Q S S
Sbjct: 1416 QHGSGSGHSSSYEQHGSRSGQSSRGERHGSSSGSSSSYGQHGSGS 1460
Score = 39.7 bits (91), Expect = 0.008
Identities = 125/567 (22%), Positives = 171/567 (30%), Gaps = 117/567 (20%)
Query: 23 GQKGGSKGQLPSGSSQ--FPHGQKGQHYFGQKDQQHTKSKGSFSIQHTYHVDINDHDWTR 80
GQ G GQ SGS Q HG H+ Q T + S S QH +
Sbjct: 812 GQASGF-GQHESGSGQGYSQHGSASGHFSSQGRHGSTSGQSSSSGQH------DSSSGQS 864
Query: 81 KSQQYDLNALHKATKSKQHLGGSQQLLNYKQEGRD---------HDKSKGHFHMIVIHHK 131
S +A H A+ +H GS Q + Q G H G H
Sbjct: 865 SSYGQHESASHHASGRGRHGSGSGQSPGHGQRGSGSGQSPSYGRHGSGSGRSSSSGRHGS 924
Query: 132 G-----GQAHHGTQNPSQDQGNSPSGKGLSSQCSNTEKRLWVHGLSKEQASASGAQKGRT 186
G G H + S SG G SS R S++ S+SG+
Sbjct: 925 GSGQSSGFGHKSSSGQSSGYTQHGSGSGHSSSYEQHGSRSGQSSRSEQHGSSSGSSSSYG 984
Query: 187 QGGSQSSYVLQTEELVVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHPAHQDRL 246
Q GS S Q+ GH Q H S S P+ R
Sbjct: 985 QHGS---------------------GSRQSLGHGQ--------HGSGSGQSPSPS---RG 1012
Query: 247 QHGPKDIFTTQDELLVYNKNQHQTKNLSQDQE-HGRKAHKISYPSSRTEERQLHHGEKSV 305
+HG Q+ + + G + + Y S L H E
Sbjct: 1013 RHG---------------SGSGQSSSYGPYRSGSGWSSSRGPYESGSGHSSGLGHRESRS 1057
Query: 306 QKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSSTEERHLNCGEKGI 365
+ G HG S + H Q HG ST + +CG+ G
Sbjct: 1058 GQSSGYGQ---------HGSSSGHSSTHGQ---HG-----------STSGQSSSCGQHGA 1094
Query: 366 QKGVSK-----GSISIQTE---EQIHGKSQNQVRIPSQAQEYGHKENKISY-QSSSTEER 416
G S GS S Q+ Q G Q+ P Q SY + S R
Sbjct: 1095 SSGQSSSHGQHGSGSSQSSGYGRQGSGSGQS----PGHGQRGSGSRQSPSYGRHGSGSGR 1150
Query: 417 RLNSGEKDVQKGVSKGSISIQTEEKIHGKSQNQVTIPS-QDQEHGHKENKMSYQSSSTEE 475
+SG+ G S G E G+S + S G+ ++ SS E
Sbjct: 1151 SSSSGQHGSGLGESSG---FGHHESSSGQSSSYSQHGSGSGHSSGYGQHGSRSGQSSRGE 1207
Query: 476 RRLNYGGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQNAKGKSGQSADSKQ 535
R + G S+ S +G +P+ G++ G S+ +
Sbjct: 1208 RHGSSSGSSSHYGQHGSGSRQSSGHGRQGSGSGHSPS------RGRHGSGLGHSSSHGQH 1261
Query: 536 DLLSHEQKGRYKQESSESHNIVITEHE 562
S R ES H+ V +HE
Sbjct: 1262 GSGSGRSSSRGPYESRSGHSSVFGQHE 1288
Score = 38.1 bits (87), Expect = 0.022
Identities = 83/392 (21%), Positives = 126/392 (32%), Gaps = 70/392 (17%)
Query: 17 KQAAVMGQKGGSKGQLPS------------GSSQFPHGQ-------KGQHYFGQKDQQ-- 55
+Q+ GQ G GQ PS SS P+G +G + G
Sbjct: 2401 RQSLGHGQHGSGSGQSPSPSRGRHGSGSGQSSSYSPYGSGSGWSSSRGPYESGSGHSSGL 2460
Query: 56 -HTKSKGSFSIQHTYHVDINDHDWTR-----KSQQYDLNALHKATKSK-----QHLGGSQ 104
H +S+ S + H + H T S Q H A+ + QH GS
Sbjct: 2461 GHRESRSGQSSGYGQHGSSSGHSSTHGQHGSTSGQSSSCGQHGASSGQSSSHGQHGSGSS 2520
Query: 105 QLLNYKQEGRDHDKSKGHFHMIVIHHKGGQAHHGTQNPSQDQGNSPSGKGLSSQCSNT-- 162
Q Y ++G +S GH G + Q+PS + S SG+ SS +
Sbjct: 2521 QSSGYGRQGSGSGQSPGH---------GQRGSGSRQSPSYGRHGSGSGRSSSSGQHGSGL 2571
Query: 163 -EKRLWVHGLSKEQASASGAQKGRTQGGSQSSYVLQTEELVVNKQQRETKNSHQNKGHYQ 221
E + H S S+S +Q G G S + ++ +R +S + + Q
Sbjct: 2572 GESSGFGHHESSSGQSSSYSQHGSGSGHSSGYGQHGSRSGQSSRGERHGSSSGSSSHYGQ 2631
Query: 222 NVVDVREEHSSKLQTSLHPAHQDRLQHGPKDIFTTQDELLVYNKNQHQTKNLSQDQEHGR 281
+ R+ Q S R +HG L HG+
Sbjct: 2632 HGSGSRQSSGHGRQGSGSGQSPSRGRHG---------------------SGLGHSSSHGQ 2670
Query: 282 KAHKISYPSSR-TEERQLHHGEKSVQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQEHG 340
SSR E +L H Q + G S ++ HG Q
Sbjct: 2671 HGSGSGRSSSRGPYESRLGHSSVFGQHESGSGHSSAYSQ---HGSGSGHFCSQGQHGSTS 2727
Query: 341 HKENKISYQSSSTEERHLNCGEKGIQKGVSKG 372
+ + + SST + + G +G S G
Sbjct: 2728 GQSSTFDQEGSSTGQSS-SYGHRGSGSSQSSG 2758
>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
Length = 2454
Score = 49.7 bits (117), Expect = 7e-06
Identities = 117/571 (20%), Positives = 209/571 (36%), Gaps = 113/571 (19%)
Query: 81 KSQQYDLNALHKATKSKQHLGGSQQLLNYKQEGRDHDKSKGHFHMIVIHHKGGQAHHGTQ 140
+S YD + L K KS +G ++ +D D S+ H K G + G +
Sbjct: 775 ESSNYD-SELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHS-----KKGMDNQGHK 828
Query: 141 N-------PSQDQGNSPSGKGLSSQCSNTEKRLWVHGL-----SKEQASASGAQKGRTQG 188
N S D + SS +K + L K+QASAS + G
Sbjct: 829 NLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSG 888
Query: 189 GSQSSYVLQTEELVVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHPAHQDRLQ- 247
QS L+ ++ K++ + + K + D+ E+ K Q+ + D+ Q
Sbjct: 889 KEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSD-ETSEDDKKQS 947
Query: 248 -------HGPKDI--------------------FTTQDELLVYNKNQHQTKNLSQDQEHG 280
P D ++E+ + K Q KN + D E
Sbjct: 948 KKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGE-- 1005
Query: 281 RKAHKISYPSSRTEERQLHHGEKSVQKDVSKGSISIQTEE-----------KIHGKS--Q 327
+K+ KI +S+ ++ + EKS K S S + + K+ GKS +
Sbjct: 1006 KKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRK 1065
Query: 328 NQVTIHSQDQEHGHKENKISYQSSSTEERHL----NCGEKGIQKGVSKGSISIQTEEQIH 383
Q S +++ KE+ + + L N K K + GS S EE
Sbjct: 1066 RQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEESSE 1125
Query: 384 GKSQNQVRIPSQAQEYGHKENKISYQSSSTEERRL-------NSGEKDVQKGVSKGSISI 436
+ + R S+ + KE K + +ST+ ++ + E D Q + +GS
Sbjct: 1126 DNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGS--- 1182
Query: 437 QTEEKIHGKSQNQV------------------TIP---SQDQEHGHKENKMSYQSSSTEE 475
E+KI ++N V ++P D + EN+++ + EE
Sbjct: 1183 SDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIA-KKMLLEE 1241
Query: 476 RRLNYGGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQNAKGKSGQSADSKQ 535
+ N S+ +D S ++ EGK +T N++ + AK + +DS
Sbjct: 1242 IKANL---SSDEDGSSD------DEPEEGKK--RTGKQNEENPGDEEAKNQVNSESDSDS 1290
Query: 536 DLLSHEQKGRYKQESSESHNIVITEHEVAQD 566
+ +K RY+ H + +++ E ++
Sbjct: 1291 E---ESKKPRYRHRLLR-HKLTVSDGESGEE 1317
Score = 39.7 bits (91), Expect = 0.008
Identities = 84/420 (20%), Positives = 167/420 (39%), Gaps = 44/420 (10%)
Query: 159 CSNTEKRLWVHGLSKEQASASGAQKGRTQGGSQSSYVLQTEELVVNKQQRETKNSHQNKG 218
C++++KRL L + + +S Q GS SS ++ E K+QR +
Sbjct: 1084 CNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSK------ 1137
Query: 219 HYQNVVDVREEHSSKLQTSLHPAHQDRLQHGPKDIFTTQDELLVYNKNQHQTKNLSQDQE 278
+ V V+E+ + L+TS D DI +D+ +Q+ S D++
Sbjct: 1138 --KKAVIVKEKKRNSLRTSTKRKQADITSSSSSDI---EDD------DQNSIGEGSSDEQ 1186
Query: 279 HGRKAHKISYPSSRTEERQLHHGEKSVQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQE 338
+ + SS T Q G++++ K V +++ ++ +N++ +E
Sbjct: 1187 KIKPVTENLVLSSHTGFCQ-SSGDEALSKSVP---VTVDDDDD-DNDPENRIAKKMLLEE 1241
Query: 339 HGHKENKISYQSSSTEERHLNCGEKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQE 398
K N S + S+++ G+K K + + + Q++ +S + S+
Sbjct: 1242 I--KANLSSDEDGSSDDEPEE-GKKRTGKQNEENPGDEEAKNQVNSESDSDSE-ESKKPR 1297
Query: 399 YGHK--ENKISYQSS-STEERRLNSGEKDVQKGVSKGSISIQTEEK--IHGKSQNQVTIP 453
Y H+ +K++ S EE++ E KG ++ +S + E ++
Sbjct: 1298 YRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSE 1357
Query: 454 SQDQEHGH---------KENKMSYQSSSTEERRLNYGGKSTQKDVSQSSISFQIEKLVEG 504
S+D++ +EN+ SY+ + RR+ S+ ++ S S + EK E
Sbjct: 1358 SEDEQRPRTRSAKKAELEENQRSYKQKK-KRRRIKVQEDSSSENKSNSE-EEEEEKEEEE 1415
Query: 505 KSQIQTPNPNQDQWSGQNAKGKSGQSADS--KQDLLSHEQKGRYKQESSESHNIVITEHE 562
+ + + +D+ + GK + K D L E + K+E I E E
Sbjct: 1416 EEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEERRKRIAERERE 1475
>gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]
Length = 2492
Score = 49.7 bits (117), Expect = 7e-06
Identities = 117/571 (20%), Positives = 209/571 (36%), Gaps = 113/571 (19%)
Query: 81 KSQQYDLNALHKATKSKQHLGGSQQLLNYKQEGRDHDKSKGHFHMIVIHHKGGQAHHGTQ 140
+S YD + L K KS +G ++ +D D S+ H K G + G +
Sbjct: 813 ESSNYD-SELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHS-----KKGMDNQGHK 866
Query: 141 N-------PSQDQGNSPSGKGLSSQCSNTEKRLWVHGL-----SKEQASASGAQKGRTQG 188
N S D + SS +K + L K+QASAS + G
Sbjct: 867 NLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSG 926
Query: 189 GSQSSYVLQTEELVVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHPAHQDRLQ- 247
QS L+ ++ K++ + + K + D+ E+ K Q+ + D+ Q
Sbjct: 927 KEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSD-ETSEDDKKQS 985
Query: 248 -------HGPKDI--------------------FTTQDELLVYNKNQHQTKNLSQDQEHG 280
P D ++E+ + K Q KN + D E
Sbjct: 986 KKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGE-- 1043
Query: 281 RKAHKISYPSSRTEERQLHHGEKSVQKDVSKGSISIQTEE-----------KIHGKS--Q 327
+K+ KI +S+ ++ + EKS K S S + + K+ GKS +
Sbjct: 1044 KKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRK 1103
Query: 328 NQVTIHSQDQEHGHKENKISYQSSSTEERHL----NCGEKGIQKGVSKGSISIQTEEQIH 383
Q S +++ KE+ + + L N K K + GS S EE
Sbjct: 1104 RQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEESSE 1163
Query: 384 GKSQNQVRIPSQAQEYGHKENKISYQSSSTEERRL-------NSGEKDVQKGVSKGSISI 436
+ + R S+ + KE K + +ST+ ++ + E D Q + +GS
Sbjct: 1164 DNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGS--- 1220
Query: 437 QTEEKIHGKSQNQV------------------TIP---SQDQEHGHKENKMSYQSSSTEE 475
E+KI ++N V ++P D + EN+++ + EE
Sbjct: 1221 SDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIA-KKMLLEE 1279
Query: 476 RRLNYGGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQNAKGKSGQSADSKQ 535
+ N S+ +D S ++ EGK +T N++ + AK + +DS
Sbjct: 1280 IKANL---SSDEDGSSD------DEPEEGKK--RTGKQNEENPGDEEAKNQVNSESDSDS 1328
Query: 536 DLLSHEQKGRYKQESSESHNIVITEHEVAQD 566
+ +K RY+ H + +++ E ++
Sbjct: 1329 E---ESKKPRYRHRLLR-HKLTVSDGESGEE 1355
Score = 39.7 bits (91), Expect = 0.008
Identities = 84/420 (20%), Positives = 167/420 (39%), Gaps = 44/420 (10%)
Query: 159 CSNTEKRLWVHGLSKEQASASGAQKGRTQGGSQSSYVLQTEELVVNKQQRETKNSHQNKG 218
C++++KRL L + + +S Q GS SS ++ E K+QR +
Sbjct: 1122 CNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSK------ 1175
Query: 219 HYQNVVDVREEHSSKLQTSLHPAHQDRLQHGPKDIFTTQDELLVYNKNQHQTKNLSQDQE 278
+ V V+E+ + L+TS D DI +D+ +Q+ S D++
Sbjct: 1176 --KKAVIVKEKKRNSLRTSTKRKQADITSSSSSDI---EDD------DQNSIGEGSSDEQ 1224
Query: 279 HGRKAHKISYPSSRTEERQLHHGEKSVQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQE 338
+ + SS T Q G++++ K V +++ ++ +N++ +E
Sbjct: 1225 KIKPVTENLVLSSHTGFCQ-SSGDEALSKSVP---VTVDDDDD-DNDPENRIAKKMLLEE 1279
Query: 339 HGHKENKISYQSSSTEERHLNCGEKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQE 398
K N S + S+++ G+K K + + + Q++ +S + S+
Sbjct: 1280 I--KANLSSDEDGSSDDEPEE-GKKRTGKQNEENPGDEEAKNQVNSESDSDSE-ESKKPR 1335
Query: 399 YGHK--ENKISYQSS-STEERRLNSGEKDVQKGVSKGSISIQTEEK--IHGKSQNQVTIP 453
Y H+ +K++ S EE++ E KG ++ +S + E ++
Sbjct: 1336 YRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSE 1395
Query: 454 SQDQEHGH---------KENKMSYQSSSTEERRLNYGGKSTQKDVSQSSISFQIEKLVEG 504
S+D++ +EN+ SY+ + RR+ S+ ++ S S + EK E
Sbjct: 1396 SEDEQRPRTRSAKKAELEENQRSYKQKK-KRRRIKVQEDSSSENKSNSE-EEEEEKEEEE 1453
Query: 505 KSQIQTPNPNQDQWSGQNAKGKSGQSADS--KQDLLSHEQKGRYKQESSESHNIVITEHE 562
+ + + +D+ + GK + K D L E + K+E I E E
Sbjct: 1454 EEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEERRKRIAERERE 1513
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 48.9 bits (115), Expect = 1e-05
Identities = 84/374 (22%), Positives = 135/374 (36%), Gaps = 79/374 (21%)
Query: 121 GHFHMIVIHHKGGQA----------HHGTQNPSQDQGNSPSGKGLSSQCSNTEKRLWVHG 170
GH +I + K G + H Q P Q + + S S + G
Sbjct: 1089 GHSQIIKLLEKYGASSLNGCSPSPVHTMEQKPLQSLSSKVQSLTIKSNSSGST------G 1142
Query: 171 LSKEQASASGAQKGRTQGGSQSSYVLQTEELVVNKQQRETKNSHQNKGHYQNVVDVREEH 230
Q S G G T S S ++ + V++Q+ N+ ++
Sbjct: 1143 GGDMQPSLRGLPNGPTHAFSSPS---ESPDSTVDRQKSSLSNN-----------SLKSSK 1188
Query: 231 SSKLQTSLHPAHQDRLQHGPKDIFTTQDELLVYNKNQHQTKNLSQDQEHG----RKAHKI 286
+S L+T+ A Q P D F H Q Q+H R I
Sbjct: 1189 NSSLRTTSSTA---TAQTVPIDSF-------------HNLSFTEQIQQHSLPRSRSRQSI 1232
Query: 287 SYPSSRTEERQLHHGEKSVQKDVSKGSISIQ-TEEKIHGKSQNQVTIHSQDQEHGHKENK 345
PSS T+ H S + + S+ S++ T+ GKS+N S K
Sbjct: 1233 VSPSSTTQSLGQSHNSPSSEFEWSQVKPSLKSTKASKGGKSENSAKSGSA--------GK 1284
Query: 346 ISYQSSSTEERHLNCGEKGI-QKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKEN 404
+ QS+S++ + L ++G S + +Q+ +SQ ++ IPS QE G +
Sbjct: 1285 KAKQSNSSQPKVLEYEMTQFDRRGPIAKSGTAAPPKQMPAESQCKIMIPSAQQEIGRSQQ 1344
Query: 405 KISYQSSSTEERRLNSGEKDVQKGVSKGSISIQTEEKIHGKSQN----QVTIPSQDQEHG 460
+ S E+++ N I T H +S +V++P Q+ G
Sbjct: 1345 QFLIHQQSGEQKKRNG---------------IMTNPNYHLQSNQVFLGRVSVPRTMQDRG 1389
Query: 461 HKENKMSYQSSSTE 474
H+E Y SS TE
Sbjct: 1390 HQEVLEGYPSSETE 1403
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 47.0 bits (110), Expect = 5e-05
Identities = 48/263 (18%), Positives = 108/263 (41%), Gaps = 30/263 (11%)
Query: 170 GLSKEQASASGAQKGRT-----QGGSQSSYVLQTEELVVNKQQRETKNSHQNKGHYQNVV 224
G +EQ G Q+G+ Q G Q +Q +E + +Q+ + + + G + V
Sbjct: 185 GQVREQEGQMGEQEGQMGEQEEQMGEQEEQ-MQKQEEQMGEQEEQMRKQEEQMGEQEEQV 243
Query: 225 DVREEHSSKLQTSLHPAHQDRLQHGPKDIFTTQDELLVYNKNQHQTKNLSQDQEHGRKAH 284
+EE K + + Q+ ++ Q+E ++ K Q + + + +QE +
Sbjct: 244 QKQEEQVQKQEEQMRK--QEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQ 301
Query: 285 KISYPSSRTEERQLHHGEKSV-QKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKE 343
+ R +E Q+ E+ + +++ G Q E+ + + + Q+++ G +E
Sbjct: 302 E---EQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQE 358
Query: 344 NKISYQSSSTEERHLNCGEKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKE 403
++ Q ++ V K ++ +E+ K + Q+R Q ++ G ++
Sbjct: 359 EQMQKQ----------------EEQVRKQEEQMRKQEEQMRKQEEQMR--KQEEQMGEQK 400
Query: 404 NKISYQSSSTEERRLNSGEKDVQ 426
++ Q E+ GE+ Q
Sbjct: 401 EQMGEQKEQMREQEEQMGEQKEQ 423
>gi|224548936 hypothetical protein LOC100170229 [Homo sapiens]
Length = 715
Score = 46.6 bits (109), Expect = 6e-05
Identities = 85/472 (18%), Positives = 185/472 (39%), Gaps = 57/472 (12%)
Query: 142 PSQDQGNSPSGKGLSSQCSNTEKRLWVHGLSKEQASASGAQKGRTQGGSQSSYVLQTEEL 201
PS+++ ++PS SS+ + ++ + S+E++ + R + +Q+S + +
Sbjct: 226 PSKEKSDNPSPS--SSRKVKSYGQMIIP--SREKSYSPTEMSSRVKSYNQASTRSRPQSH 281
Query: 202 VVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHPAHQDRLQHGPKDIFTTQDELL 261
++ R +++ Q + H + VR HS K H + R + G +
Sbjct: 282 SQSRSPRRSRSGSQKRTHSR----VRS-HSWKRN---HSRARSRTRKGILSQMGRHSQSR 333
Query: 262 VYNKNQHQTKNLSQDQEHGR---------KAHKISYPSSRTEERQLHHGEKSVQKDVSKG 312
++K + Q N S+ GR K S+ S ++ER H G S +K+ +
Sbjct: 334 SHSKGKSQ--NQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKERD-HRGSSSPRKESGRS 390
Query: 313 SISIQTEEKIHGKSQN----------QVTIHSQDQEHGHKENKIS--------YQSSSTE 354
+++ H +S++ + ++D+ NK Y++
Sbjct: 391 QSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRS 450
Query: 355 ERHLNCGEKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTE 414
+ + S ++ + K ++ ++ S ++E H+ ++ +
Sbjct: 451 RSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCR 510
Query: 415 ERRLNSGEKDVQKGVSKGSISIQTEEKIHGKSQNQVTIPSQDQEHGHKENKMSYQSSSTE 474
+ R +S E+D ++ S + + + K +++ S +E H++++ S S E
Sbjct: 511 QSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQSR----SPSKE 566
Query: 475 ERRLNYGGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQNAKGK----SGQS 530
R + S +++ QS S + S+ ++PN Q +S A K S
Sbjct: 567 RDRRRWRSPSKERERRQSRSSSE----ERDHSRSRSPN-KQSGYSRPRASSKEKAHSRSR 621
Query: 531 ADSKQDLLSHEQKGRYKQESSESHNIVITEHEVAQDDHLTQQYNEDRNPIST 582
SK+ +H Q +ES S + V + + T +++R P T
Sbjct: 622 TPSKEG--NHSQSRTSSKESDPSQSTVPRSPDWKRSPTRTSSLSQNRTPSKT 671
>gi|4504487 histidine rich calcium binding protein precursor [Homo
sapiens]
Length = 699
Score = 46.6 bits (109), Expect = 6e-05
Identities = 86/460 (18%), Positives = 162/460 (35%), Gaps = 83/460 (18%)
Query: 91 HKATKSKQHLGGSQQLLNYKQEGRDHDKSKGHFHMIVIHHKGGQAHHGTQNPSQDQGNSP 150
H+A + + H GS++ D D S GH H H Q H + D +
Sbjct: 211 HQAHRHRGH--GSEE---------DEDVSDGHHHHGPSHRH--QGHEEDDDDDDDDDDDD 257
Query: 151 SGKGLSSQCSNTEKRLWVHGLSKEQASASGAQKGRTQGGSQSSYVLQTEELVVNKQQRET 210
+S + + R HG+ +++ + G +S ++ V+ +
Sbjct: 258 DDDDVSIEYRHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSHEEDDNDDDDVSTEYGHQ 317
Query: 211 KNSHQNKGHYQNVVDVREEHSSKLQTSLHPAHQDR-----------------LQHGPKDI 253
+ HQ+ + V V EH + H H+D + HG D
Sbjct: 318 AHRHQDH-RKEEVEAVSGEHHHHVPDHRHQGHRDEEEDEDVSTERWHQGPQHVHHGLVDE 376
Query: 254 FTTQDELLV---YNKNQHQTKNLSQDQEHGRKAHKISYPSSRTEERQLHHGEKSVQKDVS 310
++E+ V + HQ + D+E + +K P HH + +++
Sbjct: 377 EEEEEEITVQFGHYVASHQPRGHKSDEEDFQDEYKTEVPH--------HHHHRVPREEDE 428
Query: 311 KGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSSTEERHLNCGEKGIQKGVS 370
+ S + + H +S QD+E GH + + S E H G +
Sbjct: 429 EVSAELGHQAPSHRQSH-------QDEETGHGQ-----RGSIKEMSHHPPGHTVV----- 471
Query: 371 KGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEERRLNSGEKDVQKGVS 430
K ++ +R +E +E+ S++ ++ GEK G S
Sbjct: 472 --------------KDRSHLRKDDSEEEKEKEEDPGSHEE---DDESSEQGEKGTHHG-S 513
Query: 431 KGSISIQTEEKIHGKSQNQVTIPSQDQEHGHKENKMSYQSSSTEERRLNYGGK-STQKDV 489
+ + EE+ HG S NQ +++E KE + + E R G S
Sbjct: 514 RDQEDEEDEEEGHGLSLNQ-----EEEEEEDKEEEEEEEDEERREERAEVGAPLSPDHSE 568
Query: 490 SQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQNAKGKSGQ 529
+ +E+ + I P +++ G +++ +SG+
Sbjct: 569 EEEEEEEGLEEDEPRFTIIPNPLDRREEAGGASSEEESGE 608
Score = 39.3 bits (90), Expect = 0.010
Identities = 57/262 (21%), Positives = 98/262 (37%), Gaps = 52/262 (19%)
Query: 197 QTEELVVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLH----------------- 239
+ EE + Q SHQ +GH + D ++E+ +++ H
Sbjct: 377 EEEEEEITVQFGHYVASHQPRGHKSDEEDFQDEYKTEVPHHHHHRVPREEDEEVSAELGH 436
Query: 240 --PAHQDRLQ-----HGP----KDIFTTQDELLVYNKNQHQTKNLSQDQ---EHGRKAHK 285
P+H+ Q HG K++ V H K+ S+++ E +H+
Sbjct: 437 QAPSHRQSHQDEETGHGQRGSIKEMSHHPPGHTVVKDRSHLRKDDSEEEKEKEEDPGSHE 496
Query: 286 ISYPSSRTEERQLHHGEKSVQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENK 345
SS E+ HHG + + + + EE+ HG S N QE +E+K
Sbjct: 497 EDDESSEQGEKGTHHGSRDQEDE--------EDEEEGHGLSLN--------QEEEEEEDK 540
Query: 346 ISYQSSSTEERHLNCGEKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENK 405
+ EER E G S + EE+ G +++ R +E
Sbjct: 541 EEEEEEEDEERREERAEVGAPLSPDH---SEEEEEEEEGLEEDEPRFTIIPNPLDRREE- 596
Query: 406 ISYQSSSTEERRLNSGEKDVQK 427
+ +SS EE ++G +D Q+
Sbjct: 597 -AGGASSEEESGEDTGPQDAQE 617
>gi|4557509 cylicin 2 [Homo sapiens]
Length = 348
Score = 46.2 bits (108), Expect = 8e-05
Identities = 58/256 (22%), Positives = 101/256 (39%), Gaps = 19/256 (7%)
Query: 274 SQDQEHGRKAH-KISYPSSRTEERQLHHGEKSVQK--DVSKGSISIQTEEKIHGKSQNQV 330
S+ E G+K K + + E +L G+K +K D+ KG EEK+ K ++
Sbjct: 109 SKAAEIGKKGEDKTTQKDTTDSESELKQGKKDSKKGKDIEKGK-----EEKLDAKKDSKK 163
Query: 331 TIHSQDQEHGHKENKISYQSSSTEERHLNCGEKGIQKGVSKGSISIQTEEQIHGKSQNQV 390
+D E G K S S E+ K +K +KG S E G ++
Sbjct: 164 G--KKDAEKG----KDSATESEDEKGGAKKDNKKDKKDSNKGKDSATESEGEKGGTEKDS 217
Query: 391 RIPSQAQEYGHKENKISYQSSSTEERRLNSGEKDVQKGVSKGSISIQTEEKIHGKSQNQV 450
+ + + G K++ I Q+ +E++ G+KD KG +E GK +
Sbjct: 218 KKGKKDSKKG-KDSAIELQAVKADEKKDEDGKKDANKGDESKDAKKDAKEIKKGKKDKKK 276
Query: 451 TIPSQDQEHGHKENKMSYQSSSTEERRLNYGGKSTQKDVSQSSISFQIEKLVEGKSQIQT 510
PS + K + +T++ + K T+K+ + S + + K +
Sbjct: 277 --PSSTDSDSKDDVKKESKKDATKDAK-KVAKKDTEKESADSKKDAKKNAKKDAKKDAK- 332
Query: 511 PNPNQDQWSGQNAKGK 526
N +D+ KGK
Sbjct: 333 KNAKKDEKKDAKKKGK 348
>gi|171916097 repetin [Homo sapiens]
Length = 784
Score = 46.2 bits (108), Expect = 8e-05
Identities = 99/538 (18%), Positives = 184/538 (34%), Gaps = 71/538 (13%)
Query: 40 PHGQKGQHYFGQ-----KDQQHTKSKGSFSIQHTYHVDINDHD-WTRKSQQYDLNALHKA 93
P Q G + GQ +D H +S+ H + D D +S++ D +
Sbjct: 137 PERQDGDSHHGQPERQDRDSHHGQSEKQDRDSHHSQPERQDRDSHHNQSERQDKDFSFDQ 196
Query: 94 TKSKQHLGGSQQLLNYKQEGRDHDKSKGHFHM-------IVIHHKGGQAHHGTQNPSQDQ 146
++ + S + +++K K +GH I H G H Q+ + Q
Sbjct: 197 SERQSQDSSSGKKVSHKSTS-GQAKWQGHIFALNRCEKPIQDSHYGQSERHTQQSETLGQ 255
Query: 147 G---NSPSGKGLSSQCSNTEKRLWVHGLSKEQASASGAQKGRTQGGSQSSYVLQTEELVV 203
N + + S C +E+ G + + G+T QS + QT+
Sbjct: 256 ASHFNQTNQQKSGSYCGQSERLGQELGCGQTDRQGQSSHYGQTDRQDQSYHYGQTDRQGQ 315
Query: 204 NKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHPAHQDRLQHGPKDIFTTQDELLVY 263
+ +T Q+ + Q + H ++ H D+
Sbjct: 316 SSHYSQTDRQGQSSHYSQPDRQGQSSHYGQMDRKGQCYHYDQ------------------ 357
Query: 264 NKNQHQTKNLSQDQEHGRKAHKISYPSSRTEERQLHHGEKSVQKDVSKGSISIQTEEKIH 323
Q Q + SQ G+ +H Y T+++ H+G+ Q S QTE +
Sbjct: 358 TNRQGQGSHYSQPNRQGQSSH---YGQPDTQDQSSHYGQTDRQDQSSHYG---QTERQGQ 411
Query: 324 GKSQNQVTIHSQDQEHGHKENK---ISYQSSSTEERHLNCGEKGIQKGVS-------KGS 373
+Q+ Q +G + + Y + ++ + G+ Q S +G
Sbjct: 412 SSHYSQMDRQGQGSHYGQTDRQGQSSHYGQPDRQGQNSHYGQTDRQGQSSHYGQTDRQGQ 471
Query: 374 ISIQTEEQIHGKSQNQVRIPSQAQEYGHKE-----NKISYQSSSTEERRLNSGEKDVQKG 428
S ++ G+S + +I Q Q Y + + Y + + + + G+ D Q
Sbjct: 472 SSHYSQPDKQGQSSHYGKIDRQDQSYHYGQPDGQGQSSHYGQTDRQGQSFHYGQPDRQGQ 531
Query: 429 VS-------KGSISIQTEEKIHGKSQNQVTIPSQDQEHGHKENKMSYQSS---STEERRL 478
S +G S + G+S + Q Q + + + QSS ++ +
Sbjct: 532 SSHYSQMDRQGQSSHYGQTDRQGQSSHYGQTDRQGQSYHYGQTDRQGQSSHYIQSQTGEI 591
Query: 479 NYGGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQNAKGKSGQSADSKQD 536
K Q S+ + G+ QTP G +G+ QS DS+Q+
Sbjct: 592 QGQNKYFQGTEGTRKASYVEQSGRSGRLSQQTPGQ-----EGYQNQGQGFQSRDSQQN 644
Score = 45.8 bits (107), Expect = 1e-04
Identities = 78/393 (19%), Positives = 143/393 (36%), Gaps = 27/393 (6%)
Query: 172 SKEQASASGAQKGRTQGGSQSSYVLQTEELVVNKQQRETKNSHQNKGHYQNVVDVREEHS 231
S+++ GAQ + G + + + EE N + + + H Q R+ H
Sbjct: 99 SQQERGQEGAQDCKFPGNTGRQHRQRHEEERQNSHHSQPERQDGDSHHGQPERQDRDSHH 158
Query: 232 SKLQTSLHPAHQDRLQHGPKDIFTTQDELLVYNKNQHQTKNLSQDQEHGRK-AHKISYPS 290
+ + +H + + +D Q E + + Q++ SQD G+K +HK +
Sbjct: 159 GQSEKQDRDSHHSQPERQDRDSHHNQSERQDKDFSFDQSERQSQDSSSGKKVSHKSTSGQ 218
Query: 291 SRTEER--QLHHGEKSVQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISY 348
++ + L+ EK +Q D G T++ S+ +Q + K
Sbjct: 219 AKWQGHIFALNRCEKPIQ-DSHYGQSERHTQQ-----SETLGQASHFNQTNQQKSGSYCG 272
Query: 349 QSSSTEERHLNCGEKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISY 408
QS + L CG+ Q + S QT+ Q Q Q+ Y + +
Sbjct: 273 QSERLGQ-ELGCGQTDRQ---GQSSHYGQTDRQDQSYHYGQTDRQGQSSHYSQTDRQGQS 328
Query: 409 QSSSTEERRLNSGEKDVQKGVSKGSISIQTEEKIHGKSQNQVTIPSQDQEHGH---KENK 465
S +R+ S + QT + G +Q Q +G ++
Sbjct: 329 SHYSQPDRQGQSSHYGQMDRKGQCYHYDQTNRQGQGSHYSQPNRQGQSSHYGQPDTQDQS 388
Query: 466 MSYQSSSTEERRLNYGGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQNAKG 525
Y + +++ +YG Q QSS Q+++ +G QT Q GQ
Sbjct: 389 SHYGQTDRQDQSSHYGQTERQ---GQSSHYSQMDRQGQGSHYGQTDRQGQSSHYGQ--PD 443
Query: 526 KSGQSA----DSKQDLLSHEQKGRYKQESSESH 554
+ GQ++ +Q SH G+ ++ SH
Sbjct: 444 RQGQNSHYGQTDRQGQSSH--YGQTDRQGQSSH 474
>gi|55749769 CWC22 spliceosome-associated protein homolog [Homo
sapiens]
Length = 908
Score = 44.3 bits (103), Expect = 3e-04
Identities = 42/239 (17%), Positives = 90/239 (37%), Gaps = 29/239 (12%)
Query: 308 DVSKGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSSTEERHLNCGEKGIQK 367
DV + S + S++ + D E+ SS+ H + ++K
Sbjct: 660 DVEQNKSSPSSSSSASSSSESDSSDSDSDSSDSSSESSSEESDSSSISSHSSASANDVRK 719
Query: 368 GVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEERRLNSGEKDVQK 427
+ S + ++ I + N + + QE+GH+E + + S + R NS + +
Sbjct: 720 KGHGKTRSKEVDKLIRNQQTNDRKQKERRQEHGHQETRTERERRSEKHRDQNSSGSNWRD 779
Query: 428 GVSK--------------GSISIQTEEKIHGKSQNQVTIP-----------SQDQEHGHK 462
++K ++ ++++H +N+ P S++++H H+
Sbjct: 780 PITKYTSDKDVPSERNNYSRVANDRDQEMHIDLENKHGDPKKKRGERRNSFSENEKHTHR 839
Query: 463 ----ENKMSYQSSSTEERRLNYGGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQ 517
EN S ++E + G + +D Q+ + EK Q + NQD+
Sbjct: 840 IKDSENFRRKDRSKSKEMNRKHSGSRSDEDRYQNGAERRWEKSSRYSEQSRESKKNQDR 898
Score = 37.0 bits (84), Expect = 0.050
Identities = 26/151 (17%), Positives = 61/151 (40%)
Query: 403 ENKISYQSSSTEERRLNSGEKDVQKGVSKGSISIQTEEKIHGKSQNQVTIPSQDQEHGHK 462
E+ SS+ ++ DV+K + S + ++ I + N + QEHGH+
Sbjct: 695 ESSSEESDSSSISSHSSASANDVRKKGHGKTRSKEVDKLIRNQQTNDRKQKERRQEHGHQ 754
Query: 463 ENKMSYQSSSTEERRLNYGGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQN 522
E + + S + R N G + + +++ + + S++ + +N
Sbjct: 755 ETRTERERRSEKHRDQNSSGSNWRDPITKYTSDKDVPSERNNYSRVANDRDQEMHIDLEN 814
Query: 523 AKGKSGQSADSKQDLLSHEQKGRYKQESSES 553
G + +++ S +K ++ + SE+
Sbjct: 815 KHGDPKKKRGERRNSFSENEKHTHRIKDSEN 845
>gi|87299628 biorientation of chromosomes in cell division 1-like
[Homo sapiens]
Length = 3051
Score = 43.9 bits (102), Expect = 4e-04
Identities = 73/382 (19%), Positives = 149/382 (39%), Gaps = 42/382 (10%)
Query: 205 KQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHPAHQDRLQHGPKDIFTTQDELLVYN 264
+++ +T++ + + + ++ S L+ H D K + + E+
Sbjct: 668 QEETDTRDVKRQVERSEICTEEPQKQKSTLKNEKHLKKDDSETPHLKSLL--KKEVKSSK 725
Query: 265 KNQHQTKNLSQDQEHGRKAHKISYPSSRTEERQLHHGEKSV--------QKDVSKGSISI 316
+ + K S+D+ + +K +E +LH EK + Q +K S
Sbjct: 726 EKPEREKTPSEDKLSVKHKYKGDCMHKTGDETELHSSEKGLKVEENIQKQSQQTKLSSDD 785
Query: 317 QTEEKIHGKSQNQVTIHSQD----------------QEHGHKENKISYQSSSTEERHLNC 360
+TE K +++ ++++ +D +E+ KE ++S + + E +
Sbjct: 786 KTERKSKHRNERKLSVLGKDGKPVSEYIIKTDENVRKENNKKERRLSAEKTKAEHKSRRS 845
Query: 361 GEKGIQK---GVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEERR 417
+ IQK G + I++Q + + S+++ + S + K ++ ++ E+RR
Sbjct: 846 SDSKIQKDSLGSKQHGITLQRRSESY--SEDKCDMDSTNMDSNLKPEEVVHK----EKRR 899
Query: 418 LNS--GEKDVQKGVSK--GSISIQTEEKIHGKSQNQVTIPSQDQEHGHKENKMSYQSSST 473
S EK V K SK G E ++ + Q T P D+E +EN Q S
Sbjct: 900 TKSLLEEKLVLKSKSKTQGKQVKVVETELQEGATKQATTPKPDKEKNTEENDSEKQRKSK 959
Query: 474 EERR--LNYGGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQNAKGKSGQSA 531
E + G + + S S+ S Q + K + D+ + + + S
Sbjct: 960 VEDKPFEETGVEPVLETASSSAHSTQKDSSHRAKLPLAKEKYKSDK-DSTSTRLERKLSD 1018
Query: 532 DSKQDLLSHEQKGRYKQESSES 553
K L H K K++ ++S
Sbjct: 1019 GHKSRSLKHSSKDIKKKDENKS 1040
Score = 41.2 bits (95), Expect = 0.003
Identities = 77/429 (17%), Positives = 162/429 (37%), Gaps = 52/429 (12%)
Query: 192 SSYVLQTEELVVNKQQRETKN--SHQNKGHYQNVVDVREEHSSKLQT-SLHPAHQDRLQH 248
SS+ TEE VV E S + + QN + SS+ +T S+ A+ +
Sbjct: 417 SSFEEDTEEEVVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGKTKSVRHAYVHKPYL 476
Query: 249 GPKDIFTTQDELLVYNKNQHQTKNLSQ------------DQEHGRKAHKISYPSSRTEER 296
K + DEL V + Q K + +++ +KA K ++ + R
Sbjct: 477 YSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKAEKTKSSKTKGQGR 536
Query: 297 QLHHGEKSVQKDVSKGSISIQT---EEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSST 353
E+S K + + I+ E K+ K +D + + +K Q
Sbjct: 537 SSVDLEESSTKSLEPKAARIKEVLKERKVLEKKVALSKKRKKDSRNVEENSKKKQQYEED 596
Query: 354 EERHLNCGEKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGH--KENKISYQSS 411
+ L E ++ +S S + + +H KS+ + + E H ENK +
Sbjct: 597 SKETLKTSEHCEKEKIS----SSKELKHVHAKSEPS-KPARRLSESLHVVDENKNESKLE 651
Query: 412 STEERRLNS-----------GEKDVQKGVSKGSISIQTEEKIHGKSQNQVTIPSQDQEHG 460
+RR ++ +DV++ V + I + +K +N+ + D E
Sbjct: 652 REHKRRTSTPVIMEGVQEETDTRDVKRQVERSEICTEEPQKQKSTLKNEKHLKKDDSETP 711
Query: 461 HKENKMSYQSSSTEERRLNYGGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSG 520
H ++ + + S++E+ +++ + S ++ +G +T + + S
Sbjct: 712 HLKSLLKKEVKSSKEK--------PEREKTPSEDKLSVKHKYKGDCMHKTGDETELHSSE 763
Query: 521 QNAKGKSGQSADSKQDLLSHEQKGRYKQESSESHNI--------VITEHEVAQDDHLTQQ 572
+ K + S+Q LS + K K + + ++E+ + D+++ ++
Sbjct: 764 KGLKVEENIQKQSQQTKLSSDDKTERKSKHRNERKLSVLGKDGKPVSEYIIKTDENVRKE 823
Query: 573 YNEDRNPIS 581
N+ +S
Sbjct: 824 NNKKERRLS 832
Score = 38.5 bits (88), Expect = 0.017
Identities = 53/279 (18%), Positives = 110/279 (39%), Gaps = 29/279 (10%)
Query: 277 QEHGRKAHKISYPSSRTEERQLHHGEKSVQKDVSKGS----ISIQTEEKIHGKSQNQVTI 332
+E+ +K ++S ++ E + + +QKD S GS I++Q + + + + +
Sbjct: 822 KENNKKERRLSAEKTKAEHKSRRSSDSKIQKD-SLGSKQHGITLQRRSESYSEDKCDMDS 880
Query: 333 HSQD-----QEHGHKENK----------ISYQSSSTEERHLNCGEKGIQKGVSKGSISIQ 377
+ D +E HKE + + S T+ + + E +Q+G +K + + +
Sbjct: 881 TNMDSNLKPEEVVHKEKRRTKSLLEEKLVLKSKSKTQGKQVKVVETELQEGATKQATTPK 940
Query: 378 TEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEE--RRLNSGEKDVQKGVSKGSIS 435
+ K +N S+ Q E+K ++ + E +S QK S +
Sbjct: 941 PD-----KEKNTEENDSEKQRKSKVEDK-PFEETGVEPVLETASSSAHSTQKDSSHRAKL 994
Query: 436 IQTEEKIHGKSQNQVTIPSQDQEHGHKENKMSYQSSSTEERRLNYGGKSTQKDVSQSSIS 495
+EK + T + GHK + + S +++ N K+V S
Sbjct: 995 PLAKEKYKSDKDSTSTRLERKLSDGHKSRSLKHSSKDIKKKDENKSDDKDGKEVDSSHEK 1054
Query: 496 FQ-IEKLVEGKSQIQTPNPNQDQWSGQNAKGKSGQSADS 533
+ L+E K + + S + AKG+ +A++
Sbjct: 1055 ARGNSSLMEKKLSRRLCENRRGSLSQEMAKGEEKLAANT 1093
>gi|36031016 CTCL tumor antigen L14-2 [Homo sapiens]
Length = 898
Score = 43.9 bits (102), Expect = 4e-04
Identities = 74/393 (18%), Positives = 158/393 (40%), Gaps = 33/393 (8%)
Query: 215 QNKGHYQNVVDVREEHSS-----KLQTSLHPAH-------QDRLQHGPKDIFTTQDELLV 262
+NK H + VD+ E + K +T H + R++ K++ ++D+L+
Sbjct: 215 ENKKHQELFVDICSEKDNLREELKKRTETEKQHMNTIKQLESRIEELNKEVKASRDQLIA 274
Query: 263 Y-----NKNQHQTKNLSQDQEHGRKAHKISYPSSRTEERQLHHGEKS---VQKDVSKGSI 314
N Q K ++Q E K + + + GEK ++K+
Sbjct: 275 QDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRKEKETLEK 334
Query: 315 SIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSSTEERHLNCGEKGIQKGVSK--- 371
++ K K+ N++ SQ++ H+ + ++ R ++ ++ I V K
Sbjct: 335 KLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINSHVIKVKW 394
Query: 372 GSISIQTEEQIHGKSQNQVRIPS----QAQEYGHKENKISYQSSST--EERRLNSGEKDV 425
++ E H +++++++ + QA+E + K T E + S E D
Sbjct: 395 AQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNELDA 454
Query: 426 QKGVSKGSISIQTEEKIHGKSQNQVTIPS-QDQEHGHKENKMSYQSSSTEERRLNYGGKS 484
+ V+KG + Q +EK + I +D + KE ++ T+ + L
Sbjct: 455 KLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTLRTKVKCLEDERLR 514
Query: 485 TQKDVS--QSSISFQIEKLVEGKSQIQTPNPNQDQWS-GQNAKGKSGQSADSKQDLLSHE 541
T+ ++S + I+ Q ++ +++T + Q+Q G+ + +S L++
Sbjct: 515 TEDELSKYKEIINRQKAEIQNLLDKVKTADQLQEQLQRGKQEIENLKEEVESLNSLINDL 574
Query: 542 QKGRYKQESSESHNIVITEHEVAQDDHLTQQYN 574
QK ES ++ TE +++ L + N
Sbjct: 575 QKDIEGSRKRESELLLFTERLTSKNAQLQSESN 607
>gi|153251865 hypothetical protein LOC84226 [Homo sapiens]
Length = 1984
Score = 43.5 bits (101), Expect = 5e-04
Identities = 87/424 (20%), Positives = 154/424 (36%), Gaps = 57/424 (13%)
Query: 151 SGKGLSSQCSNTEKRLWVHGLSKEQASASGAQKGRTQGGSQSSYVLQTEELVVNKQQRET 210
S G++ Q ++ + L + K+ +S S R + SQ S L T V + R
Sbjct: 1460 SQSGIAFQTASVGQPL--RTVQKDSSSRSKKNFYRNETSSQESKNLSTPGTRVQARGRIL 1517
Query: 211 KNSHQNKGHYQNVVD--VREEHSSKLQTSLHPA-HQDRLQHGPKDIFTTQDELLVYNKNQ 267
S + ++++ D +EH+ HP+ +++R GP + +
Sbjct: 1518 PGSPVKRTWHRHLKDKLTHKEHN-------HPSFYRERTPRGPSERTRHNPSWRNHRSPS 1570
Query: 268 HQTKNLSQDQEH-----------GRKAHKISYPSSRTEERQLHH---GEKSVQKDVSKGS 313
+++ S ++ H RK H S Q +H E+S +S+
Sbjct: 1571 ERSQRSSLERRHHSPSQRSHCSPSRKNHSSPSERSWRSPSQRNHCSPPERSCHS-LSERG 1629
Query: 314 ISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSSTEERHLNCGEKGIQKGVSKGS 373
+ ++ G SQ + H E H+ SS+E RH + ++ +G S+ S
Sbjct: 1630 LHSPSQRSHRGPSQRR---HHSPSERSHRSPSERSHRSSSERRHRSPSQRS-HRGPSERS 1685
Query: 374 ISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEERRLNSGEKDVQKGVSKGS 433
+E + SQ R PS+ + H +K S++S + R S
Sbjct: 1686 HCSPSERRHRSPSQRSHRGPSERRH--HSPSKRSHRSPARRSHRSPS------------- 1730
Query: 434 ISIQTEEKIHGKSQNQVTIPSQDQEHGHKENKMSYQSS----STEERRLNYGGKSTQKDV 489
E H S+ PS+ + H E S S ERR +
Sbjct: 1731 -----ERSHHSPSERSHHSPSERRHHSPSERSHCSPSERSHCSPSERRHRSPSERRHHSP 1785
Query: 490 SQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQNAKGKSGQSADSKQDLLSHEQKGRYKQE 549
S+ S E+ S+ + +P + S + +S +S ++ S E+ R E
Sbjct: 1786 SEKSHHSPSERSHHSPSERRRHSPLER--SRHSLLERSHRSPSERRSHRSFERSHRRISE 1843
Query: 550 SSES 553
S S
Sbjct: 1844 RSHS 1847
Score = 40.4 bits (93), Expect = 0.005
Identities = 51/244 (20%), Positives = 86/244 (35%), Gaps = 33/244 (13%)
Query: 129 HHKGGQAHHGTQNPSQDQGNSPSGKGLSS-----QCSNTEKRLWVHGLSKE------QAS 177
HH Q H + PS+ +SPS + S CS E+ H LS+ Q S
Sbjct: 1582 HHSPSQRSHCS--PSRKNHSSPSERSWRSPSQRNHCSPPERSC--HSLSERGLHSPSQRS 1637
Query: 178 ASGAQKGRTQGGSQSSYVLQTEELVVNKQQRE----TKNSHQNKGHYQNVVDVREEHSSK 233
G + R S+ S+ +E + +R ++ SH+ + H S
Sbjct: 1638 HRGPSQRRHHSPSERSHRSPSERSHRSSSERRHRSPSQRSHRGPSERSHCSPSERRHRSP 1697
Query: 234 LQTSLHPAHQDRLQHGPKDIFTTQDELLVYNKNQHQTKNLSQDQEHGRKAHKISYPSSRT 293
Q S H +R H P +K H++ + ++H S
Sbjct: 1698 SQRS-HRGPSERRHHSP-------------SKRSHRSPARRSHRSPSERSHHSPSERSHH 1743
Query: 294 EERQLHHGEKSVQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSST 353
+ H S + S S + + +S ++ HS ++ H ++ S+ S S
Sbjct: 1744 SPSERRHHSPSERSHCSPSERSHCSPSERRHRSPSERRHHSPSEKSHHSPSERSHHSPSE 1803
Query: 354 EERH 357
RH
Sbjct: 1804 RRRH 1807
>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
Length = 1301
Score = 42.7 bits (99), Expect = 0.001
Identities = 93/485 (19%), Positives = 179/485 (36%), Gaps = 81/485 (16%)
Query: 126 IVIHHKGGQAHHGTQNPSQDQGNSPS-----GKGLSSQCSNTEKRLWVHGLSKEQASAS- 179
+++H TQ+ + +GN GK S+ + + + G + + A
Sbjct: 59 VLVHEGDRGRQENTQDGHKGEGNGSKWAEVGGKSFSTYSTLANEEGNIEGWNGDTGKAET 118
Query: 180 -------GAQKGRTQGGSQSSYVLQTEELVVNKQQRE--TKNSHQN-----KGHYQNVVD 225
G ++ T G Q + N+ T + QN GH ++V
Sbjct: 119 YGHDGIHGKEENITANGIQGQVSIIDNAGATNRSNTNGNTDKNTQNGDVGDAGHNEDVAV 178
Query: 226 VREEHSSKLQTSLHPAHQDRLQHGPKDIFTTQDELLVYN-KNQHQTKNLSQDQEHGRKAH 284
V+E+ G + +DE++ + +N+ T ++ R
Sbjct: 179 VQEDGPQVA--------------GSNNSTDNEDEIIENSCRNEGNTSEITPQINSKRNGT 224
Query: 285 KISYPSSRT-EERQLHHGEKS-----VQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQE 338
K + + T E+ L + + S +D +GS + EE +GK + + + Q+
Sbjct: 225 KEAEVTPGTGEDAGLDNSDGSPSGNGADEDEDEGSGDDEDEEAGNGKDSSNNSKGQEGQD 284
Query: 339 HGHKENKISY--QSSSTEERHLNCGEKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQA 396
HG +++ S Q+S ++E + G++ V S E N +
Sbjct: 285 HGKEDDHDSSIGQNSDSKEYYDPEGKEDPHNEVDGDKTSKSEENSAGIPEDNGSQRIEDT 344
Query: 397 QEYGHK-----ENKISYQSSS----------TEERRLNSGEKDVQKGVSKGSISIQTEEK 441
Q+ H+ EN+I+ +S + E + +SG +++ K V KG+ + ++
Sbjct: 345 QKLNHRESKRVENRITKESETHAVGKSQDKGIEIKGPSSGNRNITKEVGKGNEG-KEDKG 403
Query: 442 IHG--------KSQNQVTI---PSQDQEHGHKENKMSYQSSSTEE--RRLNYGGKSTQKD 488
HG K+Q +V P Q E G+K + S S + ++ KS Q D
Sbjct: 404 QHGMILGKGNVKTQGEVVNIEGPGQKSEPGNKVGHSNTGSDSNSDGYDSYDFDDKSMQGD 463
Query: 489 VSQSSISFQIEKLVEGKSQIQT---------PNPNQDQWSGQNAKGKSGQSADSKQDLLS 539
SS +S + + ++D +G ++KG +DS D +
Sbjct: 464 DPNSSDESNGNDDANSESDNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTNN 523
Query: 540 HEQKG 544
+ G
Sbjct: 524 SDSNG 528
>gi|238624188 diffuse panbronchiolitis critical region 1 protein [Homo
sapiens]
Length = 1393
Score = 42.4 bits (98), Expect = 0.001
Identities = 55/312 (17%), Positives = 126/312 (40%), Gaps = 38/312 (12%)
Query: 256 TQDELLVYNKNQHQTKNLSQDQEHGRKAHKISYPSSRTEERQLHHGEKS-VQKDVSKGSI 314
T+ E + N+ T + ++ E+G + + ++ + HGE++ + +++ S
Sbjct: 880 TEHEEMTPLANEKTTLSPAEPTENGERTPFTNEKTTPSSAEPTEHGERTPLANEITTPSR 939
Query: 315 SIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSSTEERHLNCGEKGIQKGVSKGSI 374
+ TE ++ ++ EHG E ++ ++ + GE+ ++ +
Sbjct: 940 AEPTEHGERIANEKATPSPAKPTEHG--ETTVNEDTTPSSAEPTENGER--TPLANENTT 995
Query: 375 SIQTEEQIHG-KSQNQVRIPSQAQEYGHKENKISYQSSSTEERRLNSGEKDVQKGVSKGS 433
+ TE HG ++ N+ PS A+ H E ++ S E+ + S K +
Sbjct: 996 TSPTESTEHGERTANEKTTPSPAEPTEHGE-----RTPSANEKTIPSPAKPTEH------ 1044
Query: 434 ISIQTEEKIHGKSQNQVTIPSQDQEHGHKENKMSYQSSSTEERRLNYGGKSTQKDVSQSS 493
EE ++N P + EHG K + + + + E +G K+T +
Sbjct: 1045 -----EEMTPSANENTTPSPVKPTEHGEKTTLANEKITLSPEGPTEHGAKTTS---ANEK 1096
Query: 494 ISFQIEKLVEGKSQIQTPNPNQDQWSGQNAKGKSGQSA-------------DSKQDLLSH 540
I+ + K E + +PN + ++ + + ++ +K+ L+H
Sbjct: 1097 ITPSLAKPTEHGERTTSPNDKITSSAAESTEHRDRATSANVITPAPAEPIKHAKRTTLAH 1156
Query: 541 EQKGRYKQESSE 552
E+ + ++S+E
Sbjct: 1157 EKMTQVTEKSTE 1168
Score = 31.6 bits (70), Expect = 2.1
Identities = 51/325 (15%), Positives = 124/325 (38%), Gaps = 33/325 (10%)
Query: 266 NQHQTKNLSQDQEHGRKAHKISYPSSRTEERQLHHGEKSVQKDVSKGSISIQTEEKIHGK 325
N++ T + ++ EHG + + ++ + HGE++ + E
Sbjct: 389 NENTTPSPAEPTEHGERTPFANDKTTSSSAESTEHGERT----------PLANENTTPSP 438
Query: 326 SQNQVTIHSQDQEHGHKENKISYQSSSTEERHLNCGEKGIQKGVSKGSISIQTEEQIHGK 385
++ ++++E EN + TE R EK V TE +
Sbjct: 439 AE-----PTENRERTANENTTPSPAGPTENRETTANEKTTLSPVE------PTENRETTA 487
Query: 386 SQNQVRIPSQAQEYGHKENKISYQSSSTEERRLNSGEK-DVQKGVSKGSISIQTEEKIHG 444
++ P++ E G + + +++S+ GE+ + + S + TE +
Sbjct: 488 NEKTTPSPAEPTENGQRTPFANEKTTSSSAEPTEHGERTPLANENTTPSPAEPTENRERT 547
Query: 445 KSQNQVTIPSQDQEHGHKENKMSYQSSSTEERRLNYGGK---STQKDVSQSSISFQIEKL 501
++ P++ E+G + + +++ + G + + +K S S+ + E+
Sbjct: 548 ANEKTTPSPAEPTENGDRTPLANEKTTPSLAEPTENGQRTPFANEKTTSSSAEPTEHEER 607
Query: 502 VEGKSQIQTPNP-----NQDQWSGQNAKGKSGQSADSKQDLLSHEQKGRYKQESSESHNI 556
++ TP+P N+++ + +N S +++ ++E+ + E +E+
Sbjct: 608 TPLANENTTPSPAEPTENRERTANENTT-PSPAGPTENREMTANEKTTLFPAEPTENRER 666
Query: 557 VITEHEVAQDDHLTQQYNEDRNPIS 581
E + T+ N R P +
Sbjct: 667 TANEKTTSSPAEPTE--NGQRTPFA 689
>gi|153792012 DNA polymerase zeta [Homo sapiens]
Length = 3130
Score = 42.4 bits (98), Expect = 0.001
Identities = 87/405 (21%), Positives = 152/405 (37%), Gaps = 49/405 (12%)
Query: 141 NPSQDQGNSPSGKGLSSQCSNTEKRLWVHGLSKEQASASGAQKGRTQGGSQSSYVLQTEE 200
N + ++ P+ ++S S ++ W S + R + S S + QT+
Sbjct: 1446 NTASEESQMPNNCFVTSLRSPIKQIAWEQKQRGFILDMSNFKPERVKPRSLSEAISQTKA 1505
Query: 201 LVVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHPAHQDRLQHGPKDIFTTQDEL 260
L K + + S +G Q+ + V +E K Q A+ TTQD L
Sbjct: 1506 LSQCKNRNVSTPSAFGEG--QSGLAVLKELLQKRQQKAQNAN------------TTQDPL 1551
Query: 261 LVYNKNQHQ-TKNLSQDQEHGR---KAHKISYPSSRTEERQLHHGEKSVQKDVSKGSISI 316
N+HQ KN+S EH + + ++ P R EK + K + S+++
Sbjct: 1552 ----SNKHQPNKNISGSLEHNKANKRTRSVTSPRKPRTPRSTKQKEK-IPKLLKVDSLNL 1606
Query: 317 QTEEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSSTEERHLN-----CGEKGIQKGVSK 371
Q ++ + I D E+ S + S + E + N G+ G S
Sbjct: 1607 QNSSQLDNSVSDDSPIFFSDPGF---ESCYSLEDSLSPEHNYNFDINTIGQTGFCSFYS- 1662
Query: 372 GSISIQTEEQIHGKSQN---QVRIPSQAQEYGHKENKISYQSSSTEERRLNSGEKDVQKG 428
GS + ++ + K + Q P QA E K +S+ + +E + ++ D
Sbjct: 1663 GSQFVPADQNLPQKFLSDAVQDLFPGQAIE---KNEFLSHDNQKCDEDKHHT--TDSASW 1717
Query: 429 VSKGSISIQTEEKIHGKSQNQVTIPSQDQEHGHKENKMSYQSSSTEERRLNYGGKSTQKD 488
+ G++S + EK TI S + H + K S+ +T + Q +
Sbjct: 1718 IRSGTLSPEIFEKS--------TIDSNENRR-HNQWKNSFHPLTTRSNSIMDSFCVQQAE 1768
Query: 489 VSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQNAKGKSGQSADS 533
S S V + + P PN W + + + GQS DS
Sbjct: 1769 DCLSEKSRLNRSSVSKEVFLSLPQPNNSDWIQGHTRKEMGQSLDS 1813
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 42.0 bits (97), Expect = 0.002
Identities = 85/453 (18%), Positives = 172/453 (37%), Gaps = 57/453 (12%)
Query: 146 QGNSPSGK-----GLSSQCSNTEKRLWVHGLSKEQASAS-----GAQKGRTQGGSQSSYV 195
+ N P+G L + S+ +++L V ++ S GA++ Q ++ Y
Sbjct: 488 ESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYT 547
Query: 196 LQTEELVVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHPAHQDRLQH----GPK 251
TE+L + ++K H NK + DV SKL+T++ +HQ ++ K
Sbjct: 548 A-TEKLSKENESLKSKLEHANKENS----DVIALWKSKLETAI-ASHQQAMEELKVSFSK 601
Query: 252 DIFTTQDELLVYNKN--------QHQTKNLSQDQEHGRKAHKISYPSSRTEERQLHHGEK 303
+ T E QH+ +NL Q+ R AH + R +
Sbjct: 602 GLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAK--------- 652
Query: 304 SVQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSSTEERHLNCGEK 363
+ K + + S++ K+++Q + +D + +E +I + + N K
Sbjct: 653 -LMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTK 711
Query: 364 GIQ------KGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEERR 417
I K + + + + + +++++ Q E K+ K + E +
Sbjct: 712 VIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSK 771
Query: 418 LNSGEKDVQKGVSKGSISIQTEEKIHGKSQNQVTIPSQDQEHGHKENKMSYQSSSTEERR 477
+S +++Q K + +E + SQ + T+ + Q K + S ++ S +
Sbjct: 772 ASSITRELQGRELKLT---NLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSM 828
Query: 478 LNYGGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQNAKGKS---------- 527
K QK+ + +S +EKL E + ++ +D+ Q K K
Sbjct: 829 QETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIM 888
Query: 528 GQSADSKQDLLSHEQKGRYKQESSESHNIVITE 560
S D+ L + R K+ E + +T+
Sbjct: 889 KMSGDNSSQLTKMNDELRLKERDVEELQLKLTK 921
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 42.0 bits (97), Expect = 0.002
Identities = 85/453 (18%), Positives = 172/453 (37%), Gaps = 57/453 (12%)
Query: 146 QGNSPSGK-----GLSSQCSNTEKRLWVHGLSKEQASAS-----GAQKGRTQGGSQSSYV 195
+ N P+G L + S+ +++L V ++ S GA++ Q ++ Y
Sbjct: 523 ESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYT 582
Query: 196 LQTEELVVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHPAHQDRLQH----GPK 251
TE+L + ++K H NK + DV SKL+T++ +HQ ++ K
Sbjct: 583 A-TEKLSKENESLKSKLEHANKENS----DVIALWKSKLETAI-ASHQQAMEELKVSFSK 636
Query: 252 DIFTTQDELLVYNKN--------QHQTKNLSQDQEHGRKAHKISYPSSRTEERQLHHGEK 303
+ T E QH+ +NL Q+ R AH + R +
Sbjct: 637 GLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAK--------- 687
Query: 304 SVQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSSTEERHLNCGEK 363
+ K + + S++ K+++Q + +D + +E +I + + N K
Sbjct: 688 -LMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTK 746
Query: 364 GIQ------KGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEERR 417
I K + + + + + +++++ Q E K+ K + E +
Sbjct: 747 VIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSK 806
Query: 418 LNSGEKDVQKGVSKGSISIQTEEKIHGKSQNQVTIPSQDQEHGHKENKMSYQSSSTEERR 477
+S +++Q K + +E + SQ + T+ + Q K + S ++ S +
Sbjct: 807 ASSITRELQGRELKLT---NLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSM 863
Query: 478 LNYGGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQNAKGKS---------- 527
K QK+ + +S +EKL E + ++ +D+ Q K K
Sbjct: 864 QETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIM 923
Query: 528 GQSADSKQDLLSHEQKGRYKQESSESHNIVITE 560
S D+ L + R K+ E + +T+
Sbjct: 924 KMSGDNSSQLTKMNDELRLKERDVEELQLKLTK 956
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 42.0 bits (97), Expect = 0.002
Identities = 75/383 (19%), Positives = 140/383 (36%), Gaps = 42/383 (10%)
Query: 203 VNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHPAHQDRLQHGPKDIFTTQDELLV 262
V K++ T+N +N ++ +K + SL AHQ L + + +
Sbjct: 968 VEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKI 1027
Query: 263 YNKNQHQTKNLSQDQEHGRKAHKISYPSSRTEERQLHHGEKSVQK-DVSKGSISIQTEEK 321
K + QT +L E +K + R E L ++S+ + K I + ++K
Sbjct: 1028 NAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKK 1087
Query: 322 IHGKSQNQVTIHSQDQEHGHKENKISYQSSSTEERHLNCGEKGIQKGVSKGSISIQTEEQ 381
SQ Q I + + KI + EE EE+
Sbjct: 1088 EFELSQLQAKIDDEQVHSLQFQKKIKELQARIEE----------------------LEEE 1125
Query: 382 IHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEERRLNSGEKDVQKGVSKGSISIQTEEK 441
I + + +I Q + + +IS + E + ++ + EE
Sbjct: 1126 IEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEE- 1184
Query: 442 IHGKSQNQVTIPSQDQEHGHKENKMSYQSSSTEERRLNYGGKSTQKDVSQSSISFQIEKL 501
Q++ T + ++ ++ Q + + + + ++ + ++ IE L
Sbjct: 1185 --ATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEAL 1242
Query: 502 VEGKSQIQ-TPNPNQDQWSGQNAKGKSGQSADSKQDLLSHE---QKGRYKQESSE-SHNI 556
+ KS I+ T +DQ+S AK D +Q L H+ QK R + ++ E SH +
Sbjct: 1243 SKSKSNIERTCRTVEDQFSEIKAK-------DEQQTQLIHDLNMQKARLQTQNGELSHRV 1295
Query: 557 VITEHEVAQ----DDHLTQQYNE 575
E ++Q LTQQ E
Sbjct: 1296 EEKESLISQLTKSKQALTQQLEE 1318
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.305 0.122 0.336
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,558,166
Number of Sequences: 37866
Number of extensions: 1047143
Number of successful extensions: 3473
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 16
Number of HSP's successfully gapped in prelim test: 296
Number of HSP's that attempted gapping in prelim test: 2931
Number of HSP's gapped (non-prelim): 596
length of query: 582
length of database: 18,247,518
effective HSP length: 108
effective length of query: 474
effective length of database: 14,157,990
effective search space: 6710887260
effective search space used: 6710887260
T: 11
A: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.