Guide to the Human Genome
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Search of human proteins with 4506885

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4506885 semenogelin II precursor [Homo sapiens]
         (582 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4506885 semenogelin II precursor [Homo sapiens]                   1177   0.0  
gi|4506883 semenogelin I isoform a preproprotein [Homo sapiens]       647   0.0  
gi|38049014 semenogelin I isoform b preproprotein [Homo sapiens]      578   e-165
gi|60097902 filaggrin [Homo sapiens]                                   69   2e-11
gi|62122917 filaggrin family member 2 [Homo sapiens]                   62   1e-09
gi|42560244 peptidylprolyl isomerase G [Homo sapiens]                  56   1e-07
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik...    53   7e-07
gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens]     51   3e-06
gi|212549782 caspase 8 associated protein 2 [Homo sapiens]             50   4e-06
gi|6912288 caspase 8 associated protein 2 [Homo sapiens]               50   4e-06
gi|212549532 caspase 8 associated protein 2 [Homo sapiens]             50   4e-06
gi|57864582 hornerin [Homo sapiens]                                    50   6e-06
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]    50   7e-06
gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]    50   7e-06
gi|62988328 ankyrin repeat domain 50 [Homo sapiens]                    49   1e-05
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi...    47   5e-05
gi|224548936 hypothetical protein LOC100170229 [Homo sapiens]          47   6e-05
gi|4504487 histidine rich calcium binding protein precursor [Hom...    47   6e-05
gi|4557509 cylicin 2 [Homo sapiens]                                    46   8e-05
gi|171916097 repetin [Homo sapiens]                                    46   8e-05
gi|55749769 CWC22 spliceosome-associated protein homolog [Homo s...    44   3e-04
gi|87299628 biorientation of chromosomes in cell division 1-like...    44   4e-04
gi|36031016 CTCL tumor antigen L14-2 [Homo sapiens]                    44   4e-04
gi|153251865 hypothetical protein LOC84226 [Homo sapiens]              44   5e-04
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]    43   0.001
gi|238624188 diffuse panbronchiolitis critical region 1 protein ...    42   0.001
gi|153792012 DNA polymerase zeta [Homo sapiens]                        42   0.001
gi|38044112 restin isoform b [Homo sapiens]                            42   0.002
gi|4506751 restin isoform a [Homo sapiens]                             42   0.002
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo...    42   0.002

>gi|4506885 semenogelin II precursor [Homo sapiens]
          Length = 582

 Score = 1177 bits (3045), Expect = 0.0
 Identities = 582/582 (100%), Positives = 582/582 (100%)

Query: 1   MKSIILFVLSLLLILEKQAAVMGQKGGSKGQLPSGSSQFPHGQKGQHYFGQKDQQHTKSK 60
           MKSIILFVLSLLLILEKQAAVMGQKGGSKGQLPSGSSQFPHGQKGQHYFGQKDQQHTKSK
Sbjct: 1   MKSIILFVLSLLLILEKQAAVMGQKGGSKGQLPSGSSQFPHGQKGQHYFGQKDQQHTKSK 60

Query: 61  GSFSIQHTYHVDINDHDWTRKSQQYDLNALHKATKSKQHLGGSQQLLNYKQEGRDHDKSK 120
           GSFSIQHTYHVDINDHDWTRKSQQYDLNALHKATKSKQHLGGSQQLLNYKQEGRDHDKSK
Sbjct: 61  GSFSIQHTYHVDINDHDWTRKSQQYDLNALHKATKSKQHLGGSQQLLNYKQEGRDHDKSK 120

Query: 121 GHFHMIVIHHKGGQAHHGTQNPSQDQGNSPSGKGLSSQCSNTEKRLWVHGLSKEQASASG 180
           GHFHMIVIHHKGGQAHHGTQNPSQDQGNSPSGKGLSSQCSNTEKRLWVHGLSKEQASASG
Sbjct: 121 GHFHMIVIHHKGGQAHHGTQNPSQDQGNSPSGKGLSSQCSNTEKRLWVHGLSKEQASASG 180

Query: 181 AQKGRTQGGSQSSYVLQTEELVVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHP 240
           AQKGRTQGGSQSSYVLQTEELVVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHP
Sbjct: 181 AQKGRTQGGSQSSYVLQTEELVVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHP 240

Query: 241 AHQDRLQHGPKDIFTTQDELLVYNKNQHQTKNLSQDQEHGRKAHKISYPSSRTEERQLHH 300
           AHQDRLQHGPKDIFTTQDELLVYNKNQHQTKNLSQDQEHGRKAHKISYPSSRTEERQLHH
Sbjct: 241 AHQDRLQHGPKDIFTTQDELLVYNKNQHQTKNLSQDQEHGRKAHKISYPSSRTEERQLHH 300

Query: 301 GEKSVQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSSTEERHLNC 360
           GEKSVQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSSTEERHLNC
Sbjct: 301 GEKSVQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSSTEERHLNC 360

Query: 361 GEKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEERRLNS 420
           GEKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEERRLNS
Sbjct: 361 GEKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEERRLNS 420

Query: 421 GEKDVQKGVSKGSISIQTEEKIHGKSQNQVTIPSQDQEHGHKENKMSYQSSSTEERRLNY 480
           GEKDVQKGVSKGSISIQTEEKIHGKSQNQVTIPSQDQEHGHKENKMSYQSSSTEERRLNY
Sbjct: 421 GEKDVQKGVSKGSISIQTEEKIHGKSQNQVTIPSQDQEHGHKENKMSYQSSSTEERRLNY 480

Query: 481 GGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQNAKGKSGQSADSKQDLLSH 540
           GGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQNAKGKSGQSADSKQDLLSH
Sbjct: 481 GGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQNAKGKSGQSADSKQDLLSH 540

Query: 541 EQKGRYKQESSESHNIVITEHEVAQDDHLTQQYNEDRNPIST 582
           EQKGRYKQESSESHNIVITEHEVAQDDHLTQQYNEDRNPIST
Sbjct: 541 EQKGRYKQESSESHNIVITEHEVAQDDHLTQQYNEDRNPIST 582


>gi|4506883 semenogelin I isoform a preproprotein [Homo sapiens]
          Length = 462

 Score =  647 bits (1670), Expect = 0.0
 Identities = 327/436 (75%), Positives = 365/436 (83%)

Query: 1   MKSIILFVLSLLLILEKQAAVMGQKGGSKGQLPSGSSQFPHGQKGQHYFGQKDQQHTKSK 60
           MK  I+FVLSLLLILEKQAAVMGQKGGSKG+LPS  SQFPHGQKGQHY GQK +Q T+SK
Sbjct: 1   MKPNIIFVLSLLLILEKQAAVMGQKGGSKGRLPSEFSQFPHGQKGQHYSGQKGKQQTESK 60

Query: 61  GSFSIQHTYHVDINDHDWTRKSQQYDLNALHKATKSKQHLGGSQQLLNYKQEGRDHDKSK 120
           GSFSIQ+TYHVD NDHD +RKSQQYDLNALHK TKS++HLGGSQQLL+ KQEGRDHDKSK
Sbjct: 61  GSFSIQYTYHVDANDHDQSRKSQQYDLNALHKTTKSQRHLGGSQQLLHNKQEGRDHDKSK 120

Query: 121 GHFHMIVIHHKGGQAHHGTQNPSQDQGNSPSGKGLSSQCSNTEKRLWVHGLSKEQASASG 180
           GHFH +VIHHKGG+AH GTQNPSQDQGNSPSGKG+SSQ SNTE+RLWVHGLSKEQ S SG
Sbjct: 121 GHFHRVVIHHKGGKAHRGTQNPSQDQGNSPSGKGISSQYSNTEERLWVHGLSKEQTSVSG 180

Query: 181 AQKGRTQGGSQSSYVLQTEELVVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHP 240
           AQKGR QGGSQSSYVLQTEELV NKQQRETKNSHQNKGHYQNVV+VREEHSSK+QTSL P
Sbjct: 181 AQKGRKQGGSQSSYVLQTEELVANKQQRETKNSHQNKGHYQNVVEVREEHSSKVQTSLCP 240

Query: 241 AHQDRLQHGPKDIFTTQDELLVYNKNQHQTKNLSQDQEHGRKAHKISYPSSRTEERQLHH 300
           AHQD+LQHG KDIF+TQDELLVYNKNQHQTKNL+QDQ+HGRKA+KISY SS TEER+LH+
Sbjct: 241 AHQDKLQHGSKDIFSTQDELLVYNKNQHQTKNLNQDQQHGRKANKISYQSSSTEERRLHY 300

Query: 301 GEKSVQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSSTEERHLNC 360
           GE  VQKDVS+ SI  QTEEK  GKSQ Q+TI SQ+QEH  K NKISYQSSSTEER L+ 
Sbjct: 301 GENGVQKDVSQSSIYSQTEEKAQGKSQKQITIPSQEQEHSQKANKISYQSSSTEERRLHY 360

Query: 361 GEKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEERRLNS 420
           GE G+QK VS+ SI  QTE+ + GKSQ Q   P Q   +G      S QS++ E+  L+ 
Sbjct: 361 GENGVQKDVSQRSIYSQTEKLVAGKSQIQAPNPKQEPWHGENAKGESGQSTNREQDLLSH 420

Query: 421 GEKDVQKGVSKGSISI 436
            +K   +  S G + I
Sbjct: 421 EQKGRHQHGSHGGLDI 436



 Score =  288 bits (738), Expect = 7e-78
 Identities = 189/447 (42%), Positives = 244/447 (54%), Gaps = 26/447 (5%)

Query: 153 KGLSSQCSNTEKRLWVHGLSKEQASASGAQKGRTQGGSQSSYVLQTEELVVNKQQRETKN 212
           KG S     +E   + HG   +  S    QKG+ Q  S+ S+ +Q    V      +++ 
Sbjct: 25  KGGSKGRLPSEFSQFPHGQKGQHYSG---QKGKQQTESKGSFSIQYTYHVDANDHDQSRK 81

Query: 213 SHQNKGHYQNVVDVREEHSSKLQTSLHPAHQDRLQHGPKDIFTTQDELLVYNKN---QHQ 269
           S Q   +  +     + H    Q  LH   + R     K  F     +++++K       
Sbjct: 82  SQQYDLNALHKTTKSQRHLGGSQQLLHNKQEGRDHDKSKGHF---HRVVIHHKGGKAHRG 138

Query: 270 TKNLSQDQEHGRKAHKISYPSSRTEERQLHHGEKSVQKDVS-----------KGSISIQT 318
           T+N SQDQ +      IS   S TEER   HG    Q  VS           + S  +QT
Sbjct: 139 TQNPSQDQGNSPSGKGISSQYSNTEERLWVHGLSKEQTSVSGAQKGRKQGGSQSSYVLQT 198

Query: 319 EEKIHGKSQNQVTIHSQDQEHGHKENKISYQ---SSSTEERHLNCGEKGIQKGVSKGSIS 375
           EE +  K Q +    +  Q  GH +N +  +   SS  +       +  +Q G SK   S
Sbjct: 199 EELVANKQQRETK--NSHQNKGHYQNVVEVREEHSSKVQTSLCPAHQDKLQHG-SKDIFS 255

Query: 376 IQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEERRLNSGEKDVQKGVSKGSIS 435
            Q E  ++ K+Q+Q +  +Q Q++G K NKISYQSSSTEERRL+ GE  VQK VS+ SI 
Sbjct: 256 TQDELLVYNKNQHQTKNLNQDQQHGRKANKISYQSSSTEERRLHYGENGVQKDVSQSSIY 315

Query: 436 IQTEEKIHGKSQNQVTIPSQDQEHGHKENKMSYQSSSTEERRLNYGGKSTQKDVSQSSIS 495
            QTEEK  GKSQ Q+TIPSQ+QEH  K NK+SYQSSSTEERRL+YG    QKDVSQ SI 
Sbjct: 316 SQTEEKAQGKSQKQITIPSQEQEHSQKANKISYQSSSTEERRLHYGENGVQKDVSQRSIY 375

Query: 496 FQIEKLVEGKSQIQTPNPNQDQWSGQNAKGKSGQSADSKQDLLSHEQKGRYKQESSESHN 555
            Q EKLV GKSQIQ PNP Q+ W G+NAKG+SGQS + +QDLLSHEQKGR++  S    +
Sbjct: 376 SQTEKLVAGKSQIQAPNPKQEPWHGENAKGESGQSTNREQDLLSHEQKGRHQHGSHGGLD 435

Query: 556 IVITEHEVAQDDHLTQQYNEDRNPIST 582
           IVI E E   D HL Q  N DRNP+ T
Sbjct: 436 IVIIEQEDDSDRHLAQHLNNDRNPLFT 462


>gi|38049014 semenogelin I isoform b preproprotein [Homo sapiens]
          Length = 402

 Score =  578 bits (1490), Expect = e-165
 Identities = 291/381 (76%), Positives = 322/381 (84%)

Query: 1   MKSIILFVLSLLLILEKQAAVMGQKGGSKGQLPSGSSQFPHGQKGQHYFGQKDQQHTKSK 60
           MK  I+FVLSLLLILEKQAAVMGQKGGSKG+LPS  SQFPHGQKGQHY GQK +Q T+SK
Sbjct: 1   MKPNIIFVLSLLLILEKQAAVMGQKGGSKGRLPSEFSQFPHGQKGQHYSGQKGKQQTESK 60

Query: 61  GSFSIQHTYHVDINDHDWTRKSQQYDLNALHKATKSKQHLGGSQQLLNYKQEGRDHDKSK 120
           GSFSIQ+TYHVD NDHD +RKSQQYDLNALHK TKS++HLGGSQQLL+ KQEGRDHDKSK
Sbjct: 61  GSFSIQYTYHVDANDHDQSRKSQQYDLNALHKTTKSQRHLGGSQQLLHNKQEGRDHDKSK 120

Query: 121 GHFHMIVIHHKGGQAHHGTQNPSQDQGNSPSGKGLSSQCSNTEKRLWVHGLSKEQASASG 180
           GHFH +VIHHKGG+AH GTQNPSQDQGNSPSGKG+SSQ SNTE+RLWVHGLSKEQ S SG
Sbjct: 121 GHFHRVVIHHKGGKAHRGTQNPSQDQGNSPSGKGISSQYSNTEERLWVHGLSKEQTSVSG 180

Query: 181 AQKGRTQGGSQSSYVLQTEELVVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHP 240
           AQKGR QGGSQSSYVLQTEELV NKQQRETKNSHQNKGHYQNVV+VREEHSSK+QTSL P
Sbjct: 181 AQKGRKQGGSQSSYVLQTEELVANKQQRETKNSHQNKGHYQNVVEVREEHSSKVQTSLCP 240

Query: 241 AHQDRLQHGPKDIFTTQDELLVYNKNQHQTKNLSQDQEHGRKAHKISYPSSRTEERQLHH 300
           AHQD+LQHG KDIF+TQDELLVYNKNQHQTKNL+QDQ+HGRKA+KISY SS TEER+LH+
Sbjct: 241 AHQDKLQHGSKDIFSTQDELLVYNKNQHQTKNLNQDQQHGRKANKISYQSSSTEERRLHY 300

Query: 301 GEKSVQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSSTEERHLNC 360
           GE  VQKDVS+ SI  QTEEK  GKSQ Q     Q+  HG      S QS++ E+  L+ 
Sbjct: 301 GENGVQKDVSQSSIYSQTEEKAQGKSQIQAPNPKQEPWHGENAKGESGQSTNREQDLLSH 360

Query: 361 GEKGIQKGVSKGSISIQTEEQ 381
            +KG  +  S G + I   EQ
Sbjct: 361 EQKGRHQHGSHGGLDIVIIEQ 381



 Score =  210 bits (535), Expect = 3e-54
 Identities = 127/301 (42%), Positives = 172/301 (57%), Gaps = 15/301 (4%)

Query: 295 ERQLHHGEKSVQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSSTE 354
           ++ LH+ ++    D SKG           GK+       SQDQ +      IS Q S+TE
Sbjct: 104 QQLLHNKQEGRDHDKSKGHFHRVVIHHKGGKAHRGTQNPSQDQGNSPSGKGISSQYSNTE 163

Query: 355 ER-----------HLNCGEKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKE 403
           ER            ++  +KG ++G S+ S  +QTEE +  K Q + +  +  Q  GH +
Sbjct: 164 ERLWVHGLSKEQTSVSGAQKGRKQGGSQSSYVLQTEELVANKQQRETK--NSHQNKGHYQ 221

Query: 404 N--KISYQSSSTEERRLNSGEKDVQKGVSKGSISIQTEEKIHGKSQNQVTIPSQDQEHGH 461
           N  ++  + SS  +  L    +D  +  SK   S Q E  ++ K+Q+Q    +QDQ+HG 
Sbjct: 222 NVVEVREEHSSKVQTSLCPAHQDKLQHGSKDIFSTQDELLVYNKNQHQTKNLNQDQQHGR 281

Query: 462 KENKMSYQSSSTEERRLNYGGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQ 521
           K NK+SYQSSSTEERRL+YG    QKDVSQSSI  Q E+  +GKSQIQ PNP Q+ W G+
Sbjct: 282 KANKISYQSSSTEERRLHYGENGVQKDVSQSSIYSQTEEKAQGKSQIQAPNPKQEPWHGE 341

Query: 522 NAKGKSGQSADSKQDLLSHEQKGRYKQESSESHNIVITEHEVAQDDHLTQQYNEDRNPIS 581
           NAKG+SGQS + +QDLLSHEQKGR++  S    +IVI E E   D HL Q  N DRNP+ 
Sbjct: 342 NAKGESGQSTNREQDLLSHEQKGRHQHGSHGGLDIVIIEQEDDSDRHLAQHLNNDRNPLF 401

Query: 582 T 582
           T
Sbjct: 402 T 402



 Score =  138 bits (348), Expect = 1e-32
 Identities = 118/382 (30%), Positives = 173/382 (45%), Gaps = 26/382 (6%)

Query: 153 KGLSSQCSNTEKRLWVHGLSKEQASASGAQKGRTQGGSQSSYVLQTEELVVNKQQRETKN 212
           KG S     +E   + HG   +  S    QKG+ Q  S+ S+ +Q    V      +++ 
Sbjct: 25  KGGSKGRLPSEFSQFPHGQKGQHYSG---QKGKQQTESKGSFSIQYTYHVDANDHDQSRK 81

Query: 213 SHQNKGHYQNVVDVREEHSSKLQTSLHPAHQDRLQHGPKDIFTTQDELLVYNKN---QHQ 269
           S Q   +  +     + H    Q  LH   + R     K  F     +++++K       
Sbjct: 82  SQQYDLNALHKTTKSQRHLGGSQQLLHNKQEGRDHDKSKGHF---HRVVIHHKGGKAHRG 138

Query: 270 TKNLSQDQEHGRKAHKISYPSSRTEERQLHHGEKSVQKDVS-----------KGSISIQT 318
           T+N SQDQ +      IS   S TEER   HG    Q  VS           + S  +QT
Sbjct: 139 TQNPSQDQGNSPSGKGISSQYSNTEERLWVHGLSKEQTSVSGAQKGRKQGGSQSSYVLQT 198

Query: 319 EEKIHGKSQNQVTIHSQDQEHGHKENKISYQ---SSSTEERHLNCGEKGIQKGVSKGSIS 375
           EE +  K Q +    +  Q  GH +N +  +   SS  +       +  +Q G SK   S
Sbjct: 199 EELVANKQQRETK--NSHQNKGHYQNVVEVREEHSSKVQTSLCPAHQDKLQHG-SKDIFS 255

Query: 376 IQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEERRLNSGEKDVQKGVSKGSIS 435
            Q E  ++ K+Q+Q +  +Q Q++G K NKISYQSSSTEERRL+ GE  VQK VS+ SI 
Sbjct: 256 TQDELLVYNKNQHQTKNLNQDQQHGRKANKISYQSSSTEERRLHYGENGVQKDVSQSSIY 315

Query: 436 IQTEEKIHGKSQNQVTIPSQDQEHGHKENKMSYQSSSTEERRLNYGGKSTQKDVSQSSIS 495
            QTEEK  GKSQ Q   P Q+  HG      S QS++ E+  L++  K   +  S   + 
Sbjct: 316 SQTEEKAQGKSQIQAPNPKQEPWHGENAKGESGQSTNREQDLLSHEQKGRHQHGSHGGLD 375

Query: 496 FQIEKLVEGKSQIQTPNPNQDQ 517
             I +  +   +    + N D+
Sbjct: 376 IVIIEQEDDSDRHLAQHLNNDR 397


>gi|60097902 filaggrin [Homo sapiens]
          Length = 4061

 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 122/610 (20%), Positives = 216/610 (35%), Gaps = 108/610 (17%)

Query: 26   GGSKGQLPSGSSQFPHGQKGQHYFGQKDQQHTKSKGSFSIQHTYHVDINDHDWTRKSQQY 85
            G    +  S +    H Q GQ   GQ +   T      S       D +    +  S+++
Sbjct: 2531 GSRHHEASSRADSSGHSQVGQ---GQSEGPRTSRNWGSSFSQ----DSDSQGHSEDSERW 2583

Query: 86   DLNALHKATKSKQHLGGSQ-QLLNYKQEGRDHDKSK-GHFHMIVIHHKGGQAHHGTQNPS 143
              +A      S+ H G +Q QL +  +  R H + + GH H      + G  H  T +  
Sbjct: 2584 SGSA------SRNHHGSAQEQLRDGSRHPRSHQEDRAGHGHSADSSRQSGTRHTQTSSGG 2637

Query: 144  Q-----DQGNSPSGKGLSSQCSNTEKRLWVHGLSKEQASA----------SGAQKGRTQG 188
            Q     +Q  S +G+   S    +       G+   QAS+          SG+Q    +G
Sbjct: 2638 QAASSHEQARSSAGERHGSHHQQSADSSRHSGIGHGQASSAVRDSGHRGYSGSQASDNEG 2697

Query: 189  GSQSSYVLQTEELVVNKQQRETKNSHQ------------NKGHYQNVVDVREEHSSK--- 233
             S+ S    T+ +  + Q    + SHQ            + G +   V   E+  S    
Sbjct: 2698 HSEDS---DTQSVSAHGQAGSHQQSHQESARGRSGETSGHSGSFLYQVSTHEQSESSHGW 2754

Query: 234  -------LQTSLHPAHQDRLQHGPKDIFTTQDELLVY----------------------- 263
                    Q S H   QD  +H        QD +  +                       
Sbjct: 2755 TGPSTRGRQGSRHEQAQDSSRHSASQ--DGQDTIRGHPGSSRGGRQGYHHEHSVDSSGHS 2812

Query: 264  -NKNQHQTKNLSQDQEHGRKAHKISYPSSRTEERQ--------LHHGEKSVQKDVSKGSI 314
             + + H T     D   G+   + +  ++R EE+           H E S   D+S+ S 
Sbjct: 2813 GSHHSHTTSQGRSDASRGQSGSRSASRTTRNEEQSGDGSRHSGSRHHEASTHADISRHSQ 2872

Query: 315  SIQTEEKIHGKSQNQVTIHSQDQE-HGHKENKISYQSSSTEERHLNCGEKGIQKGVSKGS 373
            ++Q + +   +S+ Q +  SQD +  GH E+   +  S++   H +  E+ ++ G S+  
Sbjct: 2873 AVQGQSEGSRRSRRQGSSVSQDSDSEGHSEDSERWSGSASRNHHGSAQEQ-LRDG-SRHP 2930

Query: 374  ISIQTEEQIHGKSQNQVRIP----SQAQEYGHKENKISYQSSSTEER----RLNSGEKDV 425
             S Q +   HG S +  R      +Q    G   +      SS  ER       S +   
Sbjct: 2931 RSHQEDRAGHGHSADSSRQSGTRHTQTSSGGQAASSHEQARSSAGERHGSHHQQSADSSR 2990

Query: 426  QKGVSKGSISIQTEEKIH-GKSQNQVTIPSQDQEHGHKENKMSYQSSSTEERRLNYGGKS 484
              G+  G  S    +  H G S +Q +      E    ++  ++  + + ++      + 
Sbjct: 2991 HSGIGHGQASSAVRDSGHRGYSGSQASDNEGHSEDSDTQSVSAHGQAGSHQQSHQESARG 3050

Query: 485  TQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQNAKGKSGQSADSKQDLLSHEQKG 544
               + S  S SF  +     +S+      +   W+G + +G+ G   +  QD   H    
Sbjct: 3051 RSGETSGHSGSFLYQVSTHEQSE------SSHGWTGPSTRGRQGSRHEQAQDSSRH-SAS 3103

Query: 545  RYKQESSESH 554
            +Y Q++   H
Sbjct: 3104 QYGQDTIRGH 3113



 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 126/557 (22%), Positives = 208/557 (37%), Gaps = 47/557 (8%)

Query: 16   EKQAAVMGQKGGSKGQLPS---GSSQFPHGQKGQHYFGQKDQQHTKSKGSFSIQHTYHVD 72
            E+Q+    +  GS+   PS   GSS+  H Q GQ   G+     T  +   S+      +
Sbjct: 1547 EEQSGDGSRHSGSRHHEPSTRAGSSR--HSQVGQ---GESAGSKTSRRQGSSVSQDRDSE 1601

Query: 73   INDHDWTRKSQQYDLNALHKATKSKQHLGGSQQLLNYKQEGRDHDKSKGHFHMIVIHH-- 130
             +  D  R+S+    N    A +  +H  GS+   +++++   H  S          H  
Sbjct: 1602 GHSEDSERRSESASRNHYGSAREQSRH--GSRNPRSHQEDRASHGHSAESSRQSGTRHAE 1659

Query: 131  --KGGQA----HHGTQNPSQDQGNSPSGKGLSSQCSNTEKRL--WVHGLSKEQASASGAQ 182
               GGQA         +P +  G+       SS  S T +R    V G S  + S SG+Q
Sbjct: 1660 TSSGGQAASSQEQARSSPGERHGSRHQQSADSSTDSGTGRRQDSSVVGDSGNRGS-SGSQ 1718

Query: 183  KGRTQGGSQSSYVLQTEELVVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHPAH 242
               ++G S+ S    T+ +  + Q    + SHQ     Q+        S   Q S H   
Sbjct: 1719 ASDSEGHSEES---DTQSVSAHGQAGPHQQSHQESTRGQSGERSGRSGSFLYQVSTH--E 1773

Query: 243  QDRLQHGPKDIFTTQDELLVYNKNQHQTKN-LSQDQEHGRKAHKISYPSSRTEERQLHHG 301
            Q    HG     T   +   + + +  +++  SQ+ +   + H    P S    RQ  H 
Sbjct: 1774 QSESAHGRTGPSTGGRQRSRHEQARDSSRHSASQEGQDTIRGH----PGSSRGGRQGSHY 1829

Query: 302  EKSVQKDVSKGSISIQT---EEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSSTEERHL 358
            E+SV      GS    T   E     + Q+     S+   +  +    S  S S      
Sbjct: 1830 EQSVDSSGHSGSHHSHTTSQERSDVSRGQSGSRSVSRQTRNEKQSGDGSRHSGSRHHEAS 1889

Query: 359  NCGEKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEERRL 418
            +  +      V +G  S     +  G S +Q      +   GH E+   + S S     L
Sbjct: 1890 SRADSSRHSQVGQGQSSGPRTSRNQGSSVSQ-----DSDSQGHSEDSERW-SGSASRNHL 1943

Query: 419  NSGEKDVQKGVSKGSISIQTEEKIHGKSQNQVTIPSQDQEHGHKENKMSYQSSSTEER-R 477
             S  +  + G S+   S   +   HG S +     S+     H E+    Q++S+ E+ R
Sbjct: 1944 GSAWEQSRDG-SRHPGSHHEDRAGHGHSADS----SRQSGTRHTESSSRGQAASSHEQAR 1998

Query: 478  LNYGGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQNAKGKSGQSADSKQDL 537
             + G +       QS+ S +   +  G++     +     +SG  A    G S DS    
Sbjct: 1999 SSAGERHGSHHQLQSADSSRHSGIGHGQASSAVRDSGHRGYSGSQASDSEGHSEDSDTQS 2058

Query: 538  LSHEQK-GRYKQESSES 553
            +S + K G ++Q   ES
Sbjct: 2059 VSAQGKAGPHQQSHKES 2075



 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 141/623 (22%), Positives = 221/623 (35%), Gaps = 104/623 (16%)

Query: 23   GQKGGSKGQLPSGSSQFPHGQKGQHYFGQKDQQHTKSK--GSFSIQHTYHVDI-NDHDWT 79
            G    S  Q  SG  Q  H Q+  H    +D+   +S+  GSF  Q + H    + H WT
Sbjct: 752  GHSEDSDTQSVSGHGQAGHHQQS-HQESARDRSGERSRRSGSFLYQVSTHKQSESSHGWT 810

Query: 80   RKS---------QQYDLNALHKATKSKQ-----HLGGSQQLLNYKQEGRDHDKSKGHFHM 125
              S         +Q   N+ H A++  Q     H G S++     ++G  H++S      
Sbjct: 811  GPSTGVRQGSHHEQARDNSRHSASQDGQDTIRGHPGSSRR----GRQGSHHEQSVDRSG- 865

Query: 126  IVIHHKGGQAHHGTQNPSQDQGNSPSGKGLSSQCSNTEKR--------------LWVHG- 170
                H G    H T     D     SG   +S+ +  E++                 H  
Sbjct: 866  ----HSGSHHSHTTSQGRSDASRGQSGSRSASRTTRNEEQSRDGSRHSGSRHHEASSHAD 921

Query: 171  LSKEQASASGAQKGRTQGGSQSSYVLQTEELVVNKQQRETKNSHQNKGHYQNVVDVREEH 230
            +S+   +  G  +G      Q S V Q  +   + +  E  +   ++ H  +  + +  H
Sbjct: 922  ISRHSQAGQGQSEGSRTSRRQGSSVSQDSDSEGHSEDSERWSGSASRNHRGSAQE-QSRH 980

Query: 231  SSKLQTSLHPA--HQDRLQHG-----PKDIFTTQDELLVYNK--NQHQTKNLSQDQEHGR 281
             S+     HP   H+DR  HG      +   T   E     +  + H+    S  + HG 
Sbjct: 981  GSR-----HPRSHHEDRAGHGHSADSSRQSGTPHAETSSGGQAASSHEQARSSPGERHGS 1035

Query: 282  KAHKISYPSSRTE---ERQLHHGEKSVQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQE 338
            + H+ S  SSR      RQ     +      S GS +  +E          V+ H QD  
Sbjct: 1036 R-HQQSADSSRHSGIPRRQASSAVRDSGHWGSSGSQASDSEGHSEESDTQSVSGHGQDGP 1094

Query: 339  H--GHKEN-------------KISYQSSSTEERHLNCGEKGIQKGVSKGSISIQTEEQI- 382
            H   H+E+                YQ S+ E+     G      G  +GS   Q  +   
Sbjct: 1095 HQQSHQESARDWSGGRSGRSGSFIYQVSTHEQSESAHGRTRTSTGRRQGSHHEQARDSSR 1154

Query: 383  HGKSQ---NQVRIPSQAQEYG----HKENKI--SYQSSSTEERRLNSGEKDVQKGVSKG- 432
            H  SQ   + +R    ++  G    H E  +  S  S S      + G  D   G S   
Sbjct: 1155 HSASQEGQDTIRAHPGSRRGGRQGSHHEQSVDRSGHSGSHHSHTTSQGRSDASHGQSGSR 1214

Query: 433  SISIQT-EEKIHGKSQNQVTIPSQDQEHGHKENKMSY--QSSSTEERRLNYGGKSTQKDV 489
            S S QT ++K  G           +       ++ S   Q  S+  R   + G S  +D 
Sbjct: 1215 SASRQTRKDKQSGDGSRHSGSRHHEAASWADSSRHSQVGQEQSSGSRTSRHQGSSVSQDS 1274

Query: 490  SQSSISFQIEKLV-------EGKSQIQTPNPNQDQWSGQNAKGKSGQSADSKQDLLSHEQ 542
                 S   E+L         G S+ Q+ + ++     Q  +   G SADS +      Q
Sbjct: 1275 DSERHSDDSERLSGSASRNHHGSSREQSRDGSRHPGFHQEDRASHGHSADSSR------Q 1328

Query: 543  KGRYKQESSESHNIVITEHEVAQ 565
             G +  ESS SH   ++ HE A+
Sbjct: 1329 SGTHHTESS-SHGQAVSSHEQAR 1350



 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 127/593 (21%), Positives = 210/593 (35%), Gaps = 69/593 (11%)

Query: 20   AVMGQKGGSKGQLPSGSSQFP------HGQKGQHYFGQKDQQHTKSKGSFSIQHTYHVDI 73
            AV GQ  GS+     GSS         H +  + + G   + H  S    S   + H   
Sbjct: 3197 AVQGQSEGSRRSRRQGSSVSQDSDSEGHSEDSERWSGSASRNHRGSVQEQSRHGSRHPRS 3256

Query: 74   NDHDWTRKSQQYDLNALHKATKSKQHLGGSQQLLNYKQEGRDHDKSKGHFHMIVI---HH 130
            +  D        D  +    T+  +   G Q   +++Q      +  G  H        H
Sbjct: 3257 HHEDRAGHGHSAD-RSRQSGTRHAETSSGGQAASSHEQARSSPGERHGSRHQQSADSSRH 3315

Query: 131  KG---GQAHHGTQNPSQ--DQGNSPSGKGLSSQCSNTEKRLWVHGLS-----KEQASASG 180
             G   GQA    ++       G+  S     S+ S+T+  +  HG +       Q SA  
Sbjct: 3316 SGIPRGQASSAVRDSRHWGSSGSQASDSEGHSEESDTQS-VSGHGQAGPHQQSHQESARD 3374

Query: 181  AQKGRTQGGSQSSYVLQTEELVVNKQQRETKNSHQNKG-HYQNVVDV-REEHSSKLQTSL 238
               GR+       Y + T E   +   R   ++ + +G H++   D  R   S + Q ++
Sbjct: 3375 RSGGRSGRSGSFLYQVSTHEQSESAHGRTRTSTGRRQGSHHEQARDSSRHSASQEGQDTI 3434

Query: 239  --HPAHQDRLQHGPKDIFTTQDELLVYNKNQHQTKNLSQDQEHGRKAHKISYPSSRTEER 296
              HP    R + G     +        + + H T     D   G+   + +   +R +E+
Sbjct: 3435 RGHPGSSRRGRQGSHYEQSVDRSGHSGSHHSHTTSQGRSDASRGQSGSRSASRQTRNDEQ 3494

Query: 297  Q--------LHHGEKSVQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQE-HGHKENKIS 347
                      HH E S Q D S+ S S Q +      S+NQ +  SQD +  GH E+   
Sbjct: 3495 SGDGSRHSWSHHHEASTQADSSRHSQSGQGQSAGPRTSRNQGSSVSQDSDSQGHSEDSER 3554

Query: 348  YQSSSTEERHLNCGEKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKIS 407
            + S S    H    ++  + G S+   S   +   HG S       S+     H EN   
Sbjct: 3555 W-SGSASRNHRGSAQEQSRDG-SRHPTSHHEDRAGHGHSAES----SRQSGTHHAENSSG 3608

Query: 408  YQ-SSSTEERRLNSGEKDVQKGVSKGSISIQTEEKIHGKSQNQVTIPSQDQEHGHKENKM 466
             Q +SS E+ R ++GE+                   HG    Q    S+    GH     
Sbjct: 3609 GQAASSHEQARSSAGER-------------------HGSHHQQSADSSRHSGIGHG---- 3645

Query: 467  SYQSSSTEERRLNYGGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQNAKGK 526
              Q+SS      + G   +Q   S+        + V    Q      +  + +   + G+
Sbjct: 3646 --QASSAVRDSGHRGSSGSQASDSEGHSEDSDTQSVSAHGQAGPHQQSHQESTRGRSAGR 3703

Query: 527  SGQSADSKQDLLSHEQ-KGRYKQESSESHNIVITEHEVAQDD--HLTQQYNED 576
            SG+S      + +HEQ +  + +    +     + HE A+D   H   Q  +D
Sbjct: 3704 SGRSGSFLYQVSTHEQSESAHGRAGPSTGGRQGSRHEQARDSSRHSASQEGQD 3756



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 126/606 (20%), Positives = 212/606 (34%), Gaps = 96/606 (15%)

Query: 27   GSKGQLPSGSSQFPHGQKGQHY-FGQKDQ-QHTKSKGSFSIQHTYHVD-------INDHD 77
            GS  +   GSS+       +H  F Q+D+  H  S  S     T+H +       ++ H+
Sbjct: 1288 GSASRNHHGSSREQSRDGSRHPGFHQEDRASHGHSADSSRQSGTHHTESSSHGQAVSSHE 1347

Query: 78   WTRKSQQYDLNALHK-ATKSKQHLG-GSQQLLNYKQEGRDHDKSKGHFHMIVIHHKGGQA 135
              R S      + H+ +  S +H G G +Q  +  ++      S         H +    
Sbjct: 1348 QARSSPGERHGSRHQQSADSSRHSGIGHRQASSAVRDSGHRGSSGSQVTNSEGHSEDSDT 1407

Query: 136  H----HGTQNPSQDQGNSPSGKGLSSQCSNTEKRLWVHGLSKEQASASGAQKGRTQGGSQ 191
                 HG   P Q Q +  S +G S + S   +       S EQ+ ++  Q   + GG Q
Sbjct: 1408 QSVSAHGQAGPHQ-QSHKESARGQSGESSGRSRSFLYQVSSHEQSESTHGQTAPSTGGRQ 1466

Query: 192  SSYVLQTEELVVNKQQRETKNSHQNKGHYQNVVDVREEHSSK---LQTSLHPAHQDRLQH 248
             S            +  + +NS ++         +R    S     Q S H    DR  H
Sbjct: 1467 GS------------RHEQARNSSRHSASQDGQDTIRGHPGSSRGGRQGSYHEQSVDRSGH 1514

Query: 249  GPKDIFTTQDELLVYNKNQHQTKNLSQDQEHGRKAHKISYPSSRTEERQ--------LHH 300
                             + H T     D  HG+   + +   +R EE+           H
Sbjct: 1515 SG-------------YHHSHTTPQGRSDASHGQSGPRSASRQTRNEEQSGDGSRHSGSRH 1561

Query: 301  GEKSVQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQE-HGHKENKISYQSSSTEERHLN 359
             E S +   S+ S   Q E      S+ Q +  SQD++  GH E+    +S S    H  
Sbjct: 1562 HEPSTRAGSSRHSQVGQGESAGSKTSRRQGSSVSQDRDSEGHSEDS-ERRSESASRNHYG 1620

Query: 360  CGEKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEER-RL 418
               +  + G S+   S Q +   HG S       S+     H E     Q++S++E+ R 
Sbjct: 1621 SAREQSRHG-SRNPRSHQEDRASHGHSAES----SRQSGTRHAETSSGGQAASSQEQARS 1675

Query: 419  NSGEKDVQKGVSKGSISIQT------EEKIHGKSQNQVTIPSQ-DQEHGHKENKMS---- 467
            + GE+   +       S  +      +  + G S N+ +  SQ     GH E   +    
Sbjct: 1676 SPGERHGSRHQQSADSSTDSGTGRRQDSSVVGDSGNRGSSGSQASDSEGHSEESDTQSVS 1735

Query: 468  -------YQSSSTEERRLNYGGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSG 520
                   +Q S  E  R    G+S ++     S  +Q+    + +S      P+    +G
Sbjct: 1736 AHGQAGPHQQSHQESTR----GQSGERSGRSGSFLYQVSTHEQSESAHGRTGPS----TG 1787

Query: 521  QNAKGKSGQSADSKQDLLSHEQKGRY----------KQESSESHNIVITEHEVAQDDHLT 570
               + +  Q+ DS +   S E +             +Q S    ++  + H  +   H T
Sbjct: 1788 GRQRSRHEQARDSSRHSASQEGQDTIRGHPGSSRGGRQGSHYEQSVDSSGHSGSHHSHTT 1847

Query: 571  QQYNED 576
             Q   D
Sbjct: 1848 SQERSD 1853



 Score = 59.7 bits (143), Expect = 7e-09
 Identities = 133/655 (20%), Positives = 230/655 (35%), Gaps = 146/655 (22%)

Query: 23   GQKGGSKGQLPSGSSQFPHGQKGQHYFGQKDQQHTKSKGSFSIQHTYHVDINDH------ 76
            G+   S+GQ  SGS       + +   G      ++  GS   + + H DI+ H      
Sbjct: 2823 GRSDASRGQ--SGSRSASRTTRNEEQSGDG----SRHSGSRHHEASTHADISRHSQAVQG 2876

Query: 77   --DWTRKSQQYDLNALHKA--------------TKSKQHLGGSQ-QLLNYKQEGRDHDKS 119
              + +R+S++   +    +              + S+ H G +Q QL +  +  R H + 
Sbjct: 2877 QSEGSRRSRRQGSSVSQDSDSEGHSEDSERWSGSASRNHHGSAQEQLRDGSRHPRSHQED 2936

Query: 120  K-GHFHMIVIHHKGGQAHHGTQNPSQ-----DQGNSPSGKGLSSQCSNTEKRLWVHGLSK 173
            + GH H      + G  H  T +  Q     +Q  S +G+   S    +       G+  
Sbjct: 2937 RAGHGHSADSSRQSGTRHTQTSSGGQAASSHEQARSSAGERHGSHHQQSADSSRHSGIGH 2996

Query: 174  EQASA----------SGAQKGRTQGGSQSSYVLQTEELVVNKQQRETKNSHQ-------- 215
             QAS+          SG+Q    +G S+ S    T+ +  + Q    + SHQ        
Sbjct: 2997 GQASSAVRDSGHRGYSGSQASDNEGHSEDS---DTQSVSAHGQAGSHQQSHQESARGRSG 3053

Query: 216  ----NKGHYQNVVDVREEHSSK----------LQTSLHPAHQDRLQHGPKDIFTTQDELL 261
                + G +   V   E+  S            Q S H   QD  +H        QD + 
Sbjct: 3054 ETSGHSGSFLYQVSTHEQSESSHGWTGPSTRGRQGSRHEQAQDSSRHSASQY--GQDTIR 3111

Query: 262  VY------------------------NKNQHQTKNLSQDQEHGRKAHKISYPSSRTEERQ 297
             +                        + + H T     D   G+   + +  ++R EE+ 
Sbjct: 3112 GHPGSSRGGRQGYHHEHSVDSSGHSGSHHSHTTSQGRSDASRGQSGSRSASRTTRNEEQS 3171

Query: 298  --------LHHGEKSVQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQE-HGHKENKISY 348
                      H E S   D+S+ S ++Q + +   +S+ Q +  SQD +  GH E+   +
Sbjct: 3172 GDSSRHSVSRHHEASTHADISRHSQAVQGQSEGSRRSRRQGSSVSQDSDSEGHSEDSERW 3231

Query: 349  QSSSTEERHLNCGEKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISY 408
             S S    H    ++  + G S+   S   +   HG S ++    S+     H E     
Sbjct: 3232 -SGSASRNHRGSVQEQSRHG-SRHPRSHHEDRAGHGHSADR----SRQSGTRHAETSSGG 3285

Query: 409  Q-SSSTEERRLNSGEKDVQKGVSKGSISIQTEEKIHGKSQNQVTIPSQDQEHGHKENKMS 467
            Q +SS E+ R + GE+                   HG    Q    S+     H      
Sbjct: 3286 QAASSHEQARSSPGER-------------------HGSRHQQSADSSR-----HSGIPRG 3321

Query: 468  YQSSSTEERRLNYGGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQNAKGKS 527
              SS+  + R ++G   +Q   S+        + V G  Q      +  + +   + G+S
Sbjct: 3322 QASSAVRDSR-HWGSSGSQASDSEGHSEESDTQSVSGHGQAGPHQQSHQESARDRSGGRS 3380

Query: 528  GQSADSKQDLLSHEQK----GRYKQESSESHNIVITEHEVAQDD--HLTQQYNED 576
            G+S      + +HEQ     GR +  +        + HE A+D   H   Q  +D
Sbjct: 3381 GRSGSFLYQVSTHEQSESAHGRTRTSTGRRQG---SHHEQARDSSRHSASQEGQD 3432



 Score = 59.3 bits (142), Expect = 9e-09
 Identities = 122/607 (20%), Positives = 223/607 (36%), Gaps = 69/607 (11%)

Query: 16   EKQAAVMGQKGGSKGQLPSGSSQFPHGQKGQHYFGQKDQQHTKSKGSFSIQHTYHVDIND 75
            E+  +  G++ GS+ Q  + SS+     +GQ     +D +H  S GS +     H + +D
Sbjct: 3292 EQARSSPGERHGSRHQQSADSSRHSGIPRGQASSAVRDSRHWGSSGSQASDSEGHSEESD 3351

Query: 76   ------HDWTRKSQQYDLNALHKATKSKQHLGGS--QQLLNYKQEGRDHDKSK-GHFHMI 126
                  H      QQ    +    +  +    GS   Q+  ++Q    H +++       
Sbjct: 3352 TQSVSGHGQAGPHQQSHQESARDRSGGRSGRSGSFLYQVSTHEQSESAHGRTRTSTGRRQ 3411

Query: 127  VIHHKGGQAHHGTQNPSQDQGNS-----PSGKGLSSQCSNTEKRLWVHGLSKEQASASGA 181
              HH+  QA   +++ +  +G       P       Q S+ E+ +   G S    S + +
Sbjct: 3412 GSHHE--QARDSSRHSASQEGQDTIRGHPGSSRRGRQGSHYEQSVDRSGHSGSHHSHTTS 3469

Query: 182  Q----KGRTQGGSQSSYVLQTEELVVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTS 237
            Q      R Q GS+S+              R+T+N  Q+    ++      E S++  +S
Sbjct: 3470 QGRSDASRGQSGSRSA-------------SRQTRNDEQSGDGSRHSWSHHHEASTQADSS 3516

Query: 238  LHPAHQDRLQHGPK-----DIFTTQDELLVYNKNQHQTKNLSQDQEHGRKAHKIS----- 287
             H         GP+         +QD     +    +  + S  + H   A + S     
Sbjct: 3517 RHSQSGQGQSAGPRTSRNQGSSVSQDSDSQGHSEDSERWSGSASRNHRGSAQEQSRDGSR 3576

Query: 288  YPSSRTEERQLH-HGEKSVQK------DVSKGSISIQTEEKIHGKSQNQVTIHSQDQEHG 340
            +P+S  E+R  H H  +S ++      + S G  +  + E+    +  +   H Q     
Sbjct: 3577 HPTSHHEDRAGHGHSAESSRQSGTHHAENSSGGQAASSHEQARSSAGERHGSHHQQSADS 3636

Query: 341  HKENKISY-QSSSTEERHLNCGEKGIQKGVSKG--------SISIQTEEQIHGKSQNQVR 391
             + + I + Q+SS      + G  G Q   S+G        S+S   +   H +S  +  
Sbjct: 3637 SRHSGIGHGQASSAVRDSGHRGSSGSQASDSEGHSEDSDTQSVSAHGQAGPHQQSHQEST 3696

Query: 392  IPSQAQEYGHKENKISYQSSSTEERRLNSGEKDVQKGVSKGSISIQTEEKIHGKSQNQVT 451
                A   G +     YQ S+ E+     G      G  +GS      E+    S++  +
Sbjct: 3697 RGRSAGRSG-RSGSFLYQVSTHEQSESAHGRAGPSTGGRQGS----RHEQARDSSRHSAS 3751

Query: 452  IPSQDQEHGHKENKMSYQSSSTEERRLNYGGKSTQKDVSQSSISFQIEKLVEGKSQIQTP 511
               QD   GH  ++   +  S  E+ ++  G S       +S         +  S+  + 
Sbjct: 3752 QEGQDTIRGHPGSRRGGRQGSYHEQSVDRSGHSGSHHSHTTSQGRSDASHGQSGSRSASR 3811

Query: 512  NPNQDQWSGQNAK--GKSGQSADSKQDLLSHEQKGRYKQESSESHNIVITEHEVAQDDHL 569
                ++ SG  ++  G     A ++ D   H Q G  + ES+ S         V+QD   
Sbjct: 3812 ETRNEEQSGDGSRHSGSRHHEASTQADSSRHSQSG--QGESAGSRRSRRQGSSVSQDSD- 3868

Query: 570  TQQYNED 576
            ++ Y ED
Sbjct: 3869 SEAYPED 3875



 Score = 57.0 bits (136), Expect = 5e-08
 Identities = 113/537 (21%), Positives = 189/537 (35%), Gaps = 74/537 (13%)

Query: 50   GQKDQQHTKSKGSFSIQHTYHVDINDHDWTRKSQQYDLNALHKATKSKQHLGGSQQLLNY 109
            GQ    H +++ S   +H  H  +   D +R S      A   A +   H G S      
Sbjct: 1988 GQAASSHEQARSSAGERHGSHHQLQSADSSRHSGIGHGQA-SSAVRDSGHRGYS------ 2040

Query: 110  KQEGRDHDKSKGHFHMIVIHHKGGQAHHGTQNPSQDQGNSPSGKGLSSQCSNTEKRLWVH 169
               G     S+GH           Q   G   P Q Q +  S +G S + S         
Sbjct: 2041 ---GSQASDSEGHSEDSDTQSVSAQ---GKAGPHQ-QSHKESARGQSGESSGRSGSFLYQ 2093

Query: 170  GLSKEQASASGAQKGRTQGGSQSSYVLQTEELVVNKQQRETKNSHQNKGHYQNVVDVREE 229
              + EQ+ ++  Q   + GG Q S+  Q ++         +++S   +G      D    
Sbjct: 2094 VSTHEQSESTHGQSAPSTGGRQGSHYDQAQD--------SSRHSASQEGQ-----DTIRG 2140

Query: 230  HSSKLQTSLHPAHQ----DRLQH-GPKDIFTTQDELLVYNKNQHQTKNLSQDQEHGRKAH 284
            H    +     +HQ    DR  H G     TT       ++ Q  +++ S      RK +
Sbjct: 2141 HPGPSRGGRQGSHQEQSVDRSGHSGSHHSHTTSQGRSDASRGQSGSRSAS------RKTY 2194

Query: 285  KISYPSSRTEERQLHHGEKSVQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQE-HGHKE 343
                    +     HH E S   D S+ S+  Q +      S+ + +  SQD +  GH E
Sbjct: 2195 DKEQSGDGSRHSGSHHHEASSWADSSRHSLVGQGQSSGPRTSRPRGSSVSQDSDSEGHSE 2254

Query: 344  NKISYQSSSTEERHLNCGEKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKE 403
            +      S++   H +  E+   +  S+   S   +   HG S       S+     H E
Sbjct: 2255 DSERRSGSASRNHHGSAQEQ--SRDGSRHPRSHHEDRAGHGHSAES----SRQSGTHHAE 2308

Query: 404  NKISYQ-SSSTEERRLNSGEKDVQKGVSKGSISIQTEEKIHGKSQNQVTIPSQDQEHGHK 462
            N    Q +SS E+ R ++GE+                   HG    Q    S+    GH 
Sbjct: 2309 NSSGGQAASSHEQARSSAGER-------------------HGSHHQQSADSSRHSGIGHG 2349

Query: 463  ENKMSYQSSSTEERRLNYGGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQN 522
                  Q+SS      + G   +Q   S+        + V    Q      +  + +   
Sbjct: 2350 ------QASSAVRDSGHRGSSGSQASDSEGHSEDSDTQSVSAHGQAGPHQQSHQESTRGR 2403

Query: 523  AKGKSGQSADSKQDLLSHEQ-KGRYKQESSESHNIVITEHEVAQDD--HLTQQYNED 576
            + G+SG+S      + +HEQ +  + +  + +     + H+ A+D   H T Q  +D
Sbjct: 2404 SAGRSGRSGSFLYQVSTHEQSESAHGRTGTSTGGRQGSHHKQARDSSRHSTSQEGQD 2460



 Score = 56.6 bits (135), Expect = 6e-08
 Identities = 109/556 (19%), Positives = 192/556 (34%), Gaps = 73/556 (13%)

Query: 24   QKGGSKGQLPSGSSQF--PHGQKGQHYFGQKDQQHTKSKGSFSIQHTYHVDINDHDWTRK 81
            Q   S+G      +Q     G+ G H    K+    +S  S     ++   ++ H+ +  
Sbjct: 2043 QASDSEGHSEDSDTQSVSAQGKAGPHQQSHKESARGQSGESSGRSGSFLYQVSTHEQSES 2102

Query: 82   SQQYDLNALHKATKSKQHLGGSQQLLNYKQEGRDHDKSKGHFHMIVIHHKGGQAHHGTQN 141
            +  +  +A     +   H   +Q    +       D  +GH          G +  G Q 
Sbjct: 2103 T--HGQSAPSTGGRQGSHYDQAQDSSRHSASQEGQDTIRGH---------PGPSRGGRQG 2151

Query: 142  PSQDQGNSPSGKGLSSQCSNTEKRLWVHGLSKEQASASGAQKGRTQGGSQSSYVLQTEEL 201
              Q+Q    SG   S            H  S+ ++ AS  Q G ++  S+ +Y       
Sbjct: 2152 SHQEQSVDRSGHSGSHHS---------HTTSQGRSDASRGQSG-SRSASRKTY------- 2194

Query: 202  VVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHPAHQDRLQHGPKDI-----FTT 256
              +K+Q    + H    H+        E SS   +S H         GP+         +
Sbjct: 2195 --DKEQSGDGSRHSGSHHH--------EASSWADSSRHSLVGQGQSSGPRTSRPRGSSVS 2244

Query: 257  QDELLVYNKNQHQTKNLSQDQEHGRKAHKIS-----YPSSRTEERQLH-HGEKSVQK--- 307
            QD     +    + ++ S  + H   A + S     +P S  E+R  H H  +S ++   
Sbjct: 2245 QDSDSEGHSEDSERRSGSASRNHHGSAQEQSRDGSRHPRSHHEDRAGHGHSAESSRQSGT 2304

Query: 308  ---DVSKGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISY-QSSSTEERHLNCGEK 363
               + S G  +  + E+    +  +   H Q      + + I + Q+SS      + G  
Sbjct: 2305 HHAENSSGGQAASSHEQARSSAGERHGSHHQQSADSSRHSGIGHGQASSAVRDSGHRGSS 2364

Query: 364  GIQKGVSKG--------SISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEE 415
            G Q   S+G        S+S   +   H +S  +      A   G +     YQ S+ E+
Sbjct: 2365 GSQASDSEGHSEDSDTQSVSAHGQAGPHQQSHQESTRGRSAGRSG-RSGSFLYQVSTHEQ 2423

Query: 416  RRLNSGEKDVQKGVSKGSISIQTEEKIHGKSQNQVTIPSQDQEHGHKENKMSYQSSSTEE 475
                 G      G  +GS   Q  +     S++  +   QD  HGH  +    +  S  E
Sbjct: 2424 SESAHGRTGTSTGGRQGSHHKQARDS----SRHSTSQEGQDTIHGHPGSSSGGRQGSHYE 2479

Query: 476  RRLNYGGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQNAK--GKSGQSADS 533
            + ++  G S       +S            S+  +     D+ SG  ++  G     A S
Sbjct: 2480 QLVDRSGHSGSHHSHTTSQGRSDASHGHSGSRSASRQTRNDEQSGDGSRHSGSRHHEASS 2539

Query: 534  KQDLLSHEQKGRYKQE 549
            + D   H Q G+ + E
Sbjct: 2540 RADSSGHSQVGQGQSE 2555



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 97/461 (21%), Positives = 158/461 (34%), Gaps = 75/461 (16%)

Query: 35   GSSQFPHGQKGQHYF-----GQKDQQHTKSKGSFSIQHTYHVDINDHDWTRKSQQYD--- 86
            G S     Q G H+      GQ    H +++ S   +H  H     H  +  S ++    
Sbjct: 3589 GHSAESSRQSGTHHAENSSGGQAASSHEQARSSAGERHGSH-----HQQSADSSRHSGIG 3643

Query: 87   LNALHKATKSKQHLGGSQQLLNYKQEGRDHDKSKGHFHMIVIHHKGGQAHHGTQNPSQDQ 146
                  A +   H G S         G     S+GH            + HG   P Q Q
Sbjct: 3644 HGQASSAVRDSGHRGSS---------GSQASDSEGHSED---SDTQSVSAHGQAGPHQ-Q 3690

Query: 147  GNSPSGKGLSSQCSNTEKRLWVHGLSKEQASASGAQKGRTQGGSQSSYVLQTEELVVNKQ 206
             +  S +G S+  S           + EQ+ ++  + G + GG Q S            +
Sbjct: 3691 SHQESTRGRSAGRSGRSGSFLYQVSTHEQSESAHGRAGPSTGGRQGS------------R 3738

Query: 207  QRETKNSHQNKGHYQNVVDVREEHSSKL---QTSLHPAHQDRLQHGPKDIFTTQDELLVY 263
              + ++S ++    +    +R    S+    Q S H    DR  H               
Sbjct: 3739 HEQARDSSRHSASQEGQDTIRGHPGSRRGGRQGSYHEQSVDRSGHSG------------- 3785

Query: 264  NKNQHQTKNLSQDQEHGRKAHKISYPSSRTEERQ--------LHHGEKSVQKDVSKGSIS 315
            + + H T     D  HG+   + +   +R EE+           H E S Q D S+ S S
Sbjct: 3786 SHHSHTTSQGRSDASHGQSGSRSASRETRNEEQSGDGSRHSGSRHHEASTQADSSRHSQS 3845

Query: 316  IQTEEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSSTEERHLNCGEKGIQKGVSKGSIS 375
             Q E     +S+ Q +  SQD +          +S S    H     +  + G S+   S
Sbjct: 3846 GQGESAGSRRSRRQGSSVSQDSDSEAYPEDSERRSESASRNHHGSSREQSRDG-SRHPGS 3904

Query: 376  IQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEERRLNSGEKDVQKGVSKGSIS 435
               +   H +S       S A+E+GH        SS +++   +SG +      S  S  
Sbjct: 3905 SHRDTASHVQSSPVQSDSSTAKEHGH-------FSSLSQDSAYHSGIQSRGSPHSSSSYH 3957

Query: 436  IQTEEKIHGKSQNQV-----TIPSQDQEHGHKENKMSYQSS 471
             Q+E     K Q+ +     +  S D ++G    + S   S
Sbjct: 3958 YQSEGTERQKGQSGLVWRHGSYGSADYDYGESGFRHSQHGS 3998



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 105/565 (18%), Positives = 191/565 (33%), Gaps = 88/565 (15%)

Query: 23  GQKGGSKGQLPSGSSQFPHGQKGQHYF-GQKDQQHTKSKGSFSIQHTYHVDINDHDWTRK 81
           G + GS  +    SS+    Q+GQ    G         +GS    H   V+ + H  +  
Sbjct: 490 GGRQGSHHEQARDSSRHSASQEGQDTIRGHPGSSRGGRQGS---HHEQSVNRSGHSGSHH 546

Query: 82  SQ---QYDLNALHKATKSKQHLGGSQQLLNYKQEGRDHDKSKGHFHMIVIHHKGGQAHHG 138
           S    Q   +A H  + S+     S+Q  N +Q G       G  H    HH+       
Sbjct: 547 SHTTSQGRSDASHGQSGSRS---ASRQTRNEEQSG------DGTRHSGSRHHEASSQADS 597

Query: 139 TQNPSQDQGNSPSGKGLSSQCSNTEKRLWVHGLSKEQASASGAQKGRTQGGSQSSYVLQT 198
           +++    QG S   +   +Q S+  +     G S++    SG+      G +Q       
Sbjct: 598 SRHSQVGQGQSSGPRTSRNQGSSVSQDSDSQGHSEDSERWSGSASRNHHGSAQEQ----- 652

Query: 199 EELVVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHPAHQDRLQHGPKDIFTTQD 258
                    R  ++ H+++  + +  D     SS+   + H                TQ+
Sbjct: 653 ----SRDGSRHPRSHHEDRAGHGHSAD-----SSRKSGTRH----------------TQN 687

Query: 259 ELLVYNKNQHQTKNLSQDQEHGRKAHKISYPSSR---TEERQL--------HHGEKSVQK 307
                  + H+    S  + HG +    S  SSR   T   Q         H G    Q 
Sbjct: 688 SSSGQAASSHEQARSSAGERHGSRHQLQSADSSRHSGTGHGQASSAVRDSGHRGSSGSQA 747

Query: 308 DVSKGSISIQTEEKIHGKSQ-------NQVTIHSQDQEHGHKENKISYQSSSTEERHLNC 360
             S+G       + + G  Q       +Q +   +  E   +     YQ S+ ++   + 
Sbjct: 748 TDSEGHSEDSDTQSVSGHGQAGHHQQSHQESARDRSGERSRRSGSFLYQVSTHKQSESSH 807

Query: 361 GEKGIQKGVSKGSISIQTEEQI-HGKSQN-------QVRIPSQAQEYGHKENKI--SYQS 410
           G  G   GV +GS   Q  +   H  SQ+             + ++  H E  +  S  S
Sbjct: 808 GWTGPSTGVRQGSHHEQARDNSRHSASQDGQDTIRGHPGSSRRGRQGSHHEQSVDRSGHS 867

Query: 411 SSTEERRLNSGEKDVQKGVSKGSISIQTEEKIHGKSQNQVTIPSQDQEHGHKENKMSYQS 470
            S      + G  D  +G S    + +T       ++N+       +  G + ++ S  +
Sbjct: 868 GSHHSHTTSQGRSDASRGQSGSRSASRT-------TRNEEQSRDGSRHSGSRHHEASSHA 920

Query: 471 SSTEERRLNYGGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQNAKGKSGQS 530
             +   +   G     +   +   S   +   EG S+      + ++WSG  ++   G S
Sbjct: 921 DISRHSQAGQGQSEGSRTSRRQGSSVSQDSDSEGHSE------DSERWSGSASRNHRG-S 973

Query: 531 ADSKQDLLSHEQKGRYKQESSESHN 555
           A  +    S   +  ++  +   H+
Sbjct: 974 AQEQSRHGSRHPRSHHEDRAGHGHS 998



 Score = 46.6 bits (109), Expect = 6e-05
 Identities = 113/584 (19%), Positives = 195/584 (33%), Gaps = 77/584 (13%)

Query: 29  KGQLP-SGSSQFPHGQKGQHYFGQKDQQHTKSKGSFSIQHTYHVDINDHDWTRKSQQYDL 87
           K  LP SG     H    +H   ++++     K   S++   +   N      KS +   
Sbjct: 91  KENLPISGHKHRKHSHHDKHEDNKQEENKENRKRPSSLERRNNRKGNKG--RSKSPRETG 148

Query: 88  NALHKATKSKQHLGGSQQLLNYKQEGRDHDKSKGHFHMIVIHHKGGQAHHGTQNPSQDQG 147
              H+++  K+   G      Y    R+ +  K H      H+   +  + T+N      
Sbjct: 149 GKRHESSSEKKERKG------YSPTHREEEYGKNH------HNSSKKEKNKTENTRLGDN 196

Query: 148 NSPSGKGLSSQCSNTEKRLWVHGLSKEQASASGAQKGRTQGGSQSSYVLQTEELVVN--- 204
                + L  +  N E      G+   + +    QK    G   + Y +Q E        
Sbjct: 197 RKRLSERLEEKEDNEE------GVYDYENTGRMTQKWIQSGHIATYYTIQDEAYDTTDSL 250

Query: 205 -KQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHPAHQDRLQHGPKDIFTTQDELLVY 263
            ++ +  + S  + G   + V+ R  H +  Q  L  + + R + G +    +QD     
Sbjct: 251 LEENKIYERSRSSDGKSSSQVN-RSRHENTSQVPLQES-RTRKRRGSR---VSQDRDSEG 305

Query: 264 NKNQHQTKNLSQDQEHGRKAHKIS-----YPSSRTEERQLHHGEKSVQKDVSKGSISIQT 318
           +    +  + S  + H   A + S     +P S  E+R  H    S       G+   +T
Sbjct: 306 HSEDSERHSGSASRNHHGSAWEQSRDGSRHPRSHDEDRASHG--HSADSSRQSGTRHAET 363

Query: 319 EEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSSTEERHLNCGEKGIQKGVS----KGSI 374
             +    S ++    S  + HG       +Q S+   RH   G       VS    +GS 
Sbjct: 364 SSRGQTASSHEQARSSPGERHGS-----GHQQSADSSRHSATGRGQASSAVSDRGHRGSS 418

Query: 375 SIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEERRLNSGEKDVQKGVSKGSI 434
             Q  +   G S+N     S  Q           Q S  E  R  SGE+  + G S   +
Sbjct: 419 GSQASDS-EGHSEN-----SDTQSVSGHGKAGLRQQSHQESTRGRSGERSGRSGSSLYQV 472

Query: 435 SIQTE-EKIHGK-------------------SQNQVTIPSQDQEHGHKENKMSYQSSSTE 474
           S   + +  HG+                   S++  +   QD   GH  +    +  S  
Sbjct: 473 STHEQPDSAHGRTGTSTGGRQGSHHEQARDSSRHSASQEGQDTIRGHPGSSRGGRQGSHH 532

Query: 475 ERRLNYGGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQNAK--GKSGQSAD 532
           E+ +N  G S       +S         +  S+  +     ++ SG   +  G     A 
Sbjct: 533 EQSVNRSGHSGSHHSHTTSQGRSDASHGQSGSRSASRQTRNEEQSGDGTRHSGSRHHEAS 592

Query: 533 SKQDLLSHEQKGRYKQESSESHNIVITEHEVAQDDHLTQQYNED 576
           S+ D   H Q G   Q  S        +      D  +Q ++ED
Sbjct: 593 SQADSSRHSQVG---QGQSSGPRTSRNQGSSVSQDSDSQGHSED 633


>gi|62122917 filaggrin family member 2 [Homo sapiens]
          Length = 2391

 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 118/567 (20%), Positives = 186/567 (32%), Gaps = 100/567 (17%)

Query: 23   GQKGGSKGQLPSGSSQFPHGQKGQHYFGQKDQQHTKSKGSFS----IQHTYHVDINDHDW 78
            G    S  ++ SG S    G    H  GQ   QH +S+        I H    D   H +
Sbjct: 1500 GHSESSDSEVHSGGSHTHSG----HTHGQSGSQHGESESIIHDRHRITHGQTGDTTRHSY 1555

Query: 79   TRKSQQYDLNAL---------HKATKSKQHLGGSQQLLN----YKQEGRDHDKSKGHFHM 125
            +   Q     +           ++T S+ H GGS +  +    Y Q G  H++ +     
Sbjct: 1556 SGHEQTTQTGSRTTGRQRTSHSESTDSEVHSGGSHRPHSREHTYGQAGSQHEEPE----- 1610

Query: 126  IVIHHKGGQAH----------HGTQNPSQDQGNSPSGKGLSSQCSNTEKRLWVH-GLSKE 174
              +H + G  H          H     S  +G+  +G+  SS   +++    VH G+S  
Sbjct: 1611 FTVHERHGTTHGQIGDTTGHSHSGHGQSTQRGSRTTGRQRSSHSESSDSE--VHSGVSHT 1668

Query: 175  QASASGAQKGRTQGGSQSSYVLQTEELVVNKQQRETKNSHQN--------------KGHY 220
                +  Q G +Q G   S V +       +    T+++H +              +G  
Sbjct: 1669 HTGHTHGQAG-SQHGQSESIVPERHGTTHGQTGDTTRHAHYHHGLTTQTGSRTTGRRGSG 1727

Query: 221  QNVVDVREEHSSKLQT-SLHPAHQDRLQHGPKDIFTTQDELLVYNKNQHQTKNLSQDQEH 279
             +     E +S    T S H   Q R QHG       + E +V+ ++            H
Sbjct: 1728 HSEYSDSEGYSGVSHTHSGHTHGQARSQHG-------ESESIVHERHGTIHGQTGDTTRH 1780

Query: 280  GRKAH-KISYPSSRTEERQLHHGEKSVQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQE 338
                H + +   SRT  R+            S G       E   G SQ     HS+   
Sbjct: 1781 AHSGHGQSTQTGSRTTGRR------------SSGHSEYSDSEGHSGFSQRP---HSRGHT 1825

Query: 339  HGHKENKISYQSSSTEERH-LNCGEKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQ 397
            HG   ++     S  +ERH    G+ G   G S+           HG+S       +  +
Sbjct: 1826 HGQAGSQHGESESIVDERHGTTHGQTGDTSGHSQSG---------HGQSTQSGSSTTGRR 1876

Query: 398  EYGHKENKISYQSSSTEERRLNSGEKDVQKGVSKGSISIQTEEKIHGKSQNQVTIPSQDQ 457
              GH E+  S   S       +SG    Q     G    ++E  +H + Q          
Sbjct: 1877 RSGHSESSDSEVHSGGSHT--HSGHTHSQARSQHG----ESESTVHKRHQTTHGQTGDTT 1930

Query: 458  EHGHKENKMSYQSSSTEERRLNYGGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQ 517
            EHGH  +  + Q+ S    R   G          S +S        G++    P      
Sbjct: 1931 EHGHPSHGQTIQTGSRTTGRRGSGHSEYSDSEGPSGVSHTHSGHTHGQAGSHYPE----- 1985

Query: 518  WSGQNAKGKSGQSADSKQDLLSHEQKG 544
             SG +   + G +     D   H   G
Sbjct: 1986 -SGSSVHERHGTTHGQTADTTRHGHSG 2011



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 120/588 (20%), Positives = 200/588 (34%), Gaps = 67/588 (11%)

Query: 18   QAAVMGQKGGSKGQLPSGSSQFPHGQKGQHYFGQKDQQHTKSKGSFSIQHTYHVDINDHD 77
            Q++  GQ G   G+  SG +Q  + + GQ  +GQ     ++S G    QH          
Sbjct: 1124 QSSGFGQHGSGTGK-SSGFAQHEY-RSGQSSYGQHGTGSSQSSGCG--QH------ESGS 1173

Query: 78   WTRKSQQYDLNALHKATKSKQHLGGSQQLLNYKQEGRDHDKSKGHFHMIVIHHKGGQAHH 137
                S    ++     + S QH+  S Q   + Q G    +S G         + G   H
Sbjct: 1174 GPTTSFGQHVSGSDNFSSSGQHISDSGQSTGFGQYGSGSGQSTGLGQGESQQVESGSTVH 1233

Query: 138  GTQNPSQDQG-----NSPSGKGLSSQCSNTEKRLWVHGLSKE-------QASASGAQKGR 185
            G Q  +  Q      +S SG+G S+Q  +   R      S+        + S   ++   
Sbjct: 1234 GRQETTHGQTINTTRHSQSGQGQSTQTGSRVTRRRRSSQSENSDSEVHSKVSHRHSEHIH 1293

Query: 186  TQGGS---QSSYVLQTEELVVNKQQRETKNSHQNKGHYQNVVD-------VREEHSSKLQ 235
            TQ GS   +S   ++  +   + Q+ +T   H + GH Q+           R  HS    
Sbjct: 1294 TQAGSHYPKSGSTVRRRQGTTHGQRGDTTR-HGHSGHGQSTQTGSRTSGRQRFSHSDATD 1352

Query: 236  TSLHPA-----HQDRLQHGPKDIFTTQDELLVYNKNQHQTKNLSQDQEHGRKAHKISYP- 289
            + +H       H     H        + E  V+ +++       +   HG   H  S   
Sbjct: 1353 SEVHSGVSHRPHSQEQTHSQAGSQHGESESTVHERHETTYGQTGEATGHGHSGHGQSTQR 1412

Query: 290  -SSRTEERQLHHGEKSVQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISY 348
             S  T  R   H E S  +  S GS   Q++E+ HG++ +Q    S    HG        
Sbjct: 1413 GSRTTGRRGSGHSESSDSEVHSGGSHRPQSQEQTHGQAGSQHG-ESGSTVHGRHGTTHGQ 1471

Query: 349  QSSSTEERHLNCGEKGIQKGVSKGSISIQTEEQIHGK-SQNQVRIPSQAQEYGHKENKIS 407
               +T   H + G     K   +GS +       H + S ++V         GH   +  
Sbjct: 1472 TGDTTRHAHYHHG-----KSTQRGSSTTGRRGSGHSESSDSEVHSGGSHTHSGHTHGQSG 1526

Query: 408  YQSSSTE-----ERRLNSGE--KDVQKGVSKGSISIQTEEKIHGKSQNQVTIPSQDQEHG 460
             Q   +E       R+  G+     +   S    + QT  +  G+ +   +  +  + H 
Sbjct: 1527 SQHGESESIIHDRHRITHGQTGDTTRHSYSGHEQTTQTGSRTTGRQRTSHSESTDSEVH- 1585

Query: 461  HKENKMSYQSSSTEERRLNYGGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSG 520
                  S  S     R   YG   +Q +  + ++  +      G +  Q  +      SG
Sbjct: 1586 ------SGGSHRPHSREHTYGQAGSQHEEPEFTVHER-----HGTTHGQIGDTTGHSHSG 1634

Query: 521  QNAKGKSGQSADSKQDLLSHEQKGRYKQESSESHNIVITEHEVAQDDH 568
                 + G     +Q   SH +    +  S  SH      H  A   H
Sbjct: 1635 HGQSTQRGSRTTGRQ-RSSHSESSDSEVHSGVSHTHTGHTHGQAGSQH 1681



 Score = 53.1 bits (126), Expect = 7e-07
 Identities = 115/539 (21%), Positives = 175/539 (32%), Gaps = 89/539 (16%)

Query: 34   SGSSQFPHGQKGQHYFGQKDQQHTKSKGSFSIQH-TYHVDINDHDWTRKSQQYDLNALHK 92
            SG SQ PH +   H  GQ   QH +S+     +H T H    D     +S          
Sbjct: 1813 SGFSQRPHSRGHTH--GQAGSQHGESESIVDERHGTTHGQTGDTSGHSQSGHGQSTQSGS 1870

Query: 93   ATKSKQHLGGSQQLLNYKQEGRDHDKSKGHFHMIVIH---------HKGGQAHHGTQNPS 143
            +T  ++  G S+   +    G  H  S GH H              HK  Q  HG    +
Sbjct: 1871 STTGRRRSGHSESSDSEVHSGGSHTHS-GHTHSQARSQHGESESTVHKRHQTTHGQTGDT 1929

Query: 144  QDQGNSPSGKGLSSQCSNTEKRLWVHGLSKEQASASGAQ---KGRTQGGSQSSYVLQTEE 200
             + G+   G+ + +    T +R   H    +    SG      G T G + S Y      
Sbjct: 1930 TEHGHPSHGQTIQTGSRTTGRRGSGHSEYSDSEGPSGVSHTHSGHTHGQAGSHYPESGSS 1989

Query: 201  L-----VVNKQQRETKNSHQNKGHYQNV----------------VDVREEHSSKLQTSLH 239
            +       + Q  +T   H + GH Q+                     E HS    T   
Sbjct: 1990 VHERHGTTHGQTADTTR-HGHSGHGQSTQRGSRTTGRRASGHSEYSDSEGHSGVSHTHSG 2048

Query: 240  PAH-QDRLQHGPKDIFTTQDELLVYNKNQHQTKNL-----SQDQEHGRKAHKISYPSSRT 293
             AH Q   QHG       +     + +    T++         Q   R A +     S +
Sbjct: 2049 HAHGQAGSQHGESGSSVHERHGTTHGQTGDTTRHAHSGHGQSTQRGSRTAGRRGSGHSES 2108

Query: 294  EERQLHHGEKSVQKDVSKGSISIQTEEK---IHGKSQNQVTIHSQDQE--------HGHK 342
             + ++H G        + G    Q  E    IHG+   Q TIH Q  +        HG  
Sbjct: 2109 SDSEVHSGVSHTHSGHTYGQARSQHGESGSAIHGR---QGTIHGQTGDTTRHGQSGHGQS 2165

Query: 343  ---------ENKISYQSSSTEERH-----LNCGEKGIQKGVSKGSISIQTEEQIHGKSQN 388
                       + S+  SS  E H      + G    Q G   G  S  +     G +  
Sbjct: 2166 TQTGSRTTGRQRSSHSESSDSEVHSEASPTHSGHTHSQAGSRHGQ-SGSSGHGRQGTTHG 2224

Query: 389  QVRIPSQAQEYGHKENKISYQSSSTEERR----LNSGEKDVQKGVSK----------GSI 434
            Q    ++   YG+ ++  + + S T  RR      S + +V    S           GS 
Sbjct: 2225 QTGDTTRHAHYGYGQS--TQRGSRTTGRRGSGHSESSDSEVHSWGSHTHSGHIQGQAGSQ 2282

Query: 435  SIQTEEKIHGKSQNQVTIPSQDQEHGHKENKMSYQSSSTEERRLNYGGKSTQKDVSQSS 493
              Q    +HG+ +           HGH     S Q+ S   R  ++   S+++    SS
Sbjct: 2283 QRQPGSTVHGRLETTHGQTGDTTRHGHSGYGQSTQTGSRSSRASHFQSHSSERQRHGSS 2341



 Score = 35.8 bits (81), Expect = 0.11
 Identities = 128/555 (23%), Positives = 178/555 (32%), Gaps = 110/555 (19%)

Query: 30  GQLPSGSSQFPHGQKGQHYFGQKDQ-QHTKSKGSFSIQHTY------HVDINDHDW-TRK 81
           GQ  SG SQ      GQH +G   +  ++ S   FS    Y            H     +
Sbjct: 381 GQYGSGGSQ--SCSNGQHEYGSCGRFSNSSSSNEFSKCDQYGSGSSQSTSFEQHGTGLSQ 438

Query: 82  SQQYDLNALHKATKSKQHLGGSQQLLNYKQEGRDHDKSKGHFHMIVIHHKGGQAHHGTQN 141
           S  ++ +         QH   S Q L Y Q G    K+ G       H  G     G   
Sbjct: 439 SSGFEQHVCGSGQTCGQHESTSSQSLGYDQHGSSSGKTSGFGQ----HGSGSGQSSGFGQ 494

Query: 142 PSQDQGNSPSGKGLSSQCSNTEKRLWVHGLSKEQASASGAQKGRTQGGSQSSYVLQTEEL 201
                G S SG G     S        HG    Q+S  G  + R++   QSSY       
Sbjct: 495 CGSGSGQS-SGFGQHGSVSGQSSGFGQHGSVSGQSSGFGQHESRSR---QSSY------- 543

Query: 202 VVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHPAHQDRLQHGPKDIFTTQDELL 261
                 +    S Q+ G+ Q        + S+ +TS    H   L  G    F       
Sbjct: 544 -----GQHGSGSSQSSGYGQ--------YGSR-ETSGFGQH--GLGSGQSTGFGQ----- 582

Query: 262 VYNKNQHQTKNLSQDQEHGRKAHKISYPSSRTEERQLHHGEKSVQKDVSKGSISIQTEEK 321
            Y     Q+    Q   HG      S  SS   + +   G+ S  +  S           
Sbjct: 583 -YGSGSGQSSGFGQ---HGSG----SGQSSGFGQHESRSGQSSYGQHSS----------- 623

Query: 322 IHGKSQNQVTIHSQDQEHGHKENKISYQSSSTEERHLNCGEKGIQKGVSKG-SISIQTEE 380
             G SQ+     S   +HG ++     Q  S   +    G+ G   G S G    +    
Sbjct: 624 --GSSQS-----SGYGQHGSRQTSGFGQHGSGSSQSTGFGQYGSGSGQSSGFGQHVSGSG 676

Query: 381 QIHGKSQNQVRI-----------PSQAQEYGHKENKISYQSSSTEERRLNSGEKDV--QK 427
           Q  G  Q++ R             SQ+  YG +    S Q+S   +  L+SG+     Q 
Sbjct: 677 QSSGFGQHESRSGHSSYGQHGFGSSQSSGYG-QHGSSSGQTSGFGQHELSSGQSSSFGQH 735

Query: 428 GVSKGSISIQTEEKIHGKSQNQVTIPSQDQEHGHKENKMSY-QSSSTEERRLNYGGKSTQ 486
           G   G  S   +   HG    Q    S   +H  +  + SY Q SS   +   YG   ++
Sbjct: 736 GSGSGQSSGFGQ---HGSGSGQ---SSGFGQHESRSGQSSYGQHSSGSSQSSGYGQHGSR 789

Query: 487 KDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQNAKGKSGQSADSKQDLLSHEQKGRY 546
           +                G  Q      +Q    GQ   G SGQSA   Q      Q   +
Sbjct: 790 Q--------------TSGFGQ-HGSGSSQSTGFGQYGSG-SGQSAGFGQHGSGSGQSSGF 833

Query: 547 KQESSESHNIVITEH 561
            Q  S SH     +H
Sbjct: 834 GQHESRSHQSSYGQH 848


>gi|42560244 peptidylprolyl isomerase G [Homo sapiens]
          Length = 754

 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 59/298 (19%), Positives = 122/298 (40%), Gaps = 36/298 (12%)

Query: 264 NKNQHQTKNLSQDQEHGRKAHKISYPSSRTEERQLHHGEKSVQKDVSKGSISIQTEEKIH 323
           ++N  ++ N   ++E   K HK     S ++ER +     S + D  K  +  + + K  
Sbjct: 409 HRNVSESPNRKNEKEKKVKDHK-----SNSKERDIRRN--SEKDDKYKNKVKKRAKSKSR 461

Query: 324 GKSQNQVTIHSQDQEHGHKENKISYQSSSTEERHLNCGEKGIQKGVSKGSISIQTEEQIH 383
            KS+ +     +D +H   E K   +S S    H N  EK             + +    
Sbjct: 462 SKSKEKSKSKERDSKHNRNEEK-RMRSRSKGRDHENVKEK-------------EKQSDSK 507

Query: 384 GKSQNQVRIPSQAQEYGHKENKISYQSSSTEERRLNSGEKDVQKGVSKGSISIQTEEKIH 443
           GK Q + R   ++++   K N+  +  S  ++RR  S  ++      K S + +T E+  
Sbjct: 508 GKDQERSRSKEKSKQLESKSNEHDHSKSKEKDRRAQSRSRECDITKGKHSYNSRTRERSR 567

Query: 444 GKSQN-QVTIPSQDQE-------HGHKENKMSYQSSSTEERRLNYGGKSTQKDVSQSSIS 495
            + ++ +V   + D++       H ++E +   +  S    R    G+S  KD  +    
Sbjct: 568 SRDRSRRVRSRTHDRDRSRSKEYHRYREQEYRRRGRSRSRERRTPPGRSRSKDRRRRRRD 627

Query: 496 FQIEKLVEGKSQIQTPNPNQDQWSGQNAKGK-SGQSADSKQDLLSHEQKGRYKQESSE 552
            +  +  E +S+      N+D++  Q +K     ++++S++ + S  +       S E
Sbjct: 628 SRSSEREESQSR------NKDKYRNQESKSSHRKENSESEKRMYSKSRDHNSSNNSRE 679


>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
           protein 6 [Homo sapiens]
          Length = 724

 Score = 53.1 bits (126), Expect = 7e-07
 Identities = 69/376 (18%), Positives = 160/376 (42%), Gaps = 41/376 (10%)

Query: 152 GKGLSS-----QCSNTEKRLWVHGLSKEQASASGAQKGRTQGGSQSSYVLQTEELVVNKQ 206
           GK L S     Q    E  LW + L+++Q      Q+ + Q   +    +Q +E  + +Q
Sbjct: 332 GKELQSVSAKLQAQVEENELW-NRLNQQQEEKMWRQEEKIQEWEEK---IQEQEEKIREQ 387

Query: 207 QRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHPAHQDRLQHGPKDIFTTQDELLVYNKN 266
           + + +   +     + ++  +EE   + Q  +    +++++   + ++  ++++    + 
Sbjct: 388 EEKIREQEEKMRRQEEMMWEKEEKMRR-QEEMMWEKEEKMRRQEEMMWEKEEKIRELEEK 446

Query: 267 QHQTKNLSQDQEHGRKAHKISYPSSRTE--------ERQLHHGEKSVQKDVSKGSISIQT 318
            H+ + + + +E  ++  KI     R E        E ++   E+ +++   K     + 
Sbjct: 447 MHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEK---MWRQ 503

Query: 319 EEKIHGKSQNQVTIHSQDQEH-GHKENKISYQSSSTEERH-LNCGEKGIQKGVSKGSISI 376
           EEKIH + + +     Q+QE    +E KI  Q     ++  ++  E+ I+K   K     
Sbjct: 504 EEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEK---MW 560

Query: 377 QTEEQIHGKSQN-----------QVRIPSQAQEYGHKENKISYQSSSTEERRLNSGEKDV 425
           + EE++H + +            + +I  Q ++   +E KI  Q   T+E+    GE++ 
Sbjct: 561 RQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQE- 619

Query: 426 QKGVSKGSISIQTEEKIHGKSQNQVTIPSQDQEHGHKENKMSYQSSSTEERRLNYGGKST 485
           +K   +     + EEK+  + +    I  Q+++   +E K+  Q    +E+      +  
Sbjct: 620 EKMCEQEEKMQEQEEKMRRQEEK---IREQEKKIREQEEKIREQEEMMQEQEEKMWEQEE 676

Query: 486 QKDVSQSSISFQIEKL 501
           +    +  +  Q EK+
Sbjct: 677 KMCEQEEKMQEQEEKM 692


>gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens]
          Length = 494

 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 63/338 (18%), Positives = 134/338 (39%), Gaps = 25/338 (7%)

Query: 259 ELLVYNKNQHQTKNLSQDQEHGRKAHKI----------SYPSSRTEERQLHHGEKSVQKD 308
           E + Y+  +   + L   + +GRK   +          SY  SR+  R       S +K 
Sbjct: 146 EFVSYSDMKRALEKLDGTEVNGRKIRLVEDKPGSRRRRSYSRSRSHSRSRSRSRHS-RKS 204

Query: 309 VSKGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSSTEERHLNCGEKGIQKG 368
            S+   S  +  K   +S++     S+ +      ++   + S +  +     EK   + 
Sbjct: 205 RSRSGSSKSSHSKSRSRSRSGSRSRSKSRSRSQSRSRSKKEKSRSPSK-----EKSRSRS 259

Query: 369 VSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEERRLNSGEK-DVQK 427
            S G    ++++Q   K QN   +         +    S   S ++ERR+   ++  V +
Sbjct: 260 HSAGKSRSKSKDQAEEKIQNNDNVGKPKSRSPSRHKSKSKSRSRSQERRVEEEKRGSVSR 319

Query: 428 GVSKGSISIQTEEKIHGK----SQNQVTIPSQDQEHGHKENKMSYQSSSTEERRLNYGGK 483
           G S+     Q+  +   K    S+++    S+D+  G K ++   +S S    +     K
Sbjct: 320 GRSQEKSLRQSRSRSRSKGGSRSRSRSRSKSKDKRKGRKRSREESRSRSRSRSKSERSRK 379

Query: 484 STQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQNAKGKSGQ---SADSKQDLLSH 540
              K  S++  S + +K    +SQ ++P+ +  +   ++AK +S Q     +S+    + 
Sbjct: 380 RGSKRDSKAGSSKKKKKEDTDRSQSRSPSRSVSK-EREHAKSESSQREGRGESENAGTNQ 438

Query: 541 EQKGRYKQESSESHNIVITEHEVAQDDHLTQQYNEDRN 578
           E + R +  S    N+       ++    T+  ++ R+
Sbjct: 439 ETRSRSRSNSKSKPNLPSESRSRSKSASKTRSRSKSRS 476



 Score = 43.1 bits (100), Expect = 7e-04
 Identities = 56/324 (17%), Positives = 118/324 (36%), Gaps = 20/324 (6%)

Query: 169 HGLSKEQASASGAQKGRTQGGSQSSYVLQTEELVVNKQQRETKNSHQNKGHYQNVVDVRE 228
           H  S+ ++  S   + R+ G S+SS+           + R    S             R 
Sbjct: 191 HSRSRSRSRHSRKSRSRS-GSSKSSHSKSRSRSRSGSRSRSKSRSRSQSRSRSKKEKSRS 249

Query: 229 EHSSKLQTSLHPAHQDRLQHGPKDIFTTQDELLVYNKNQHQTKNLSQDQEHGRKAHKISY 288
               K ++  H A + R +   KD     +E +  N N  + K+ S  +   +   +   
Sbjct: 250 PSKEKSRSRSHSAGKSRSKS--KD---QAEEKIQNNDNVGKPKSRSPSRHKSKSKSRSRS 304

Query: 289 PSSRTEERQLHHGEKSVQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISY 348
              R EE +     +   ++ S      ++  K   +S+++    S+D+  G K ++   
Sbjct: 305 QERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGSRSRSRSRSKSKDKRKGRKRSREES 364

Query: 349 QSSSTEERHLNCGEKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISY 408
           +S S          K   K  SK   S + +++   +SQ++    S ++E  H +++ S 
Sbjct: 365 RSRSRSRSKSERSRKRGSKRDSKAGSSKKKKKEDTDRSQSRSPSRSVSKEREHAKSESSQ 424

Query: 409 QSSSTEERRLNSGEKDVQKGVSKGSISIQTEEKIHGKSQNQVTIPSQDQEHGHKENKMSY 468
           +    E     + +              +T  +    S+++  +PS+ +      +K   
Sbjct: 425 REGRGESENAGTNQ--------------ETRSRSRSNSKSKPNLPSESRSRSKSASKTRS 470

Query: 469 QSSSTEERRLNYGGKSTQKDVSQS 492
           +S S          +S  +  S+S
Sbjct: 471 RSKSRSRSASRSPSRSRSRSHSRS 494


>gi|212549782 caspase 8 associated protein 2 [Homo sapiens]
          Length = 1982

 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 88/422 (20%), Positives = 160/422 (37%), Gaps = 94/422 (22%)

Query: 193 SYVLQTEELVVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHPAHQDRLQHGPKD 252
           S +++T  + +N++  E  N HQ    + +    R  H +           D ++   KD
Sbjct: 116 SALIKTARVEINRKDEEISNLHQRLSEFPH---FRNNHKTARTF-------DTVK--TKD 163

Query: 253 IFTTQDELLVYNKNQHQTK-NLSQDQEHGRKAHKISYPSS-RTEERQLHHGEKSVQKDVS 310
           + +    L   +K  H+ K ++S+D  H      +       +++R   H   SV+K  +
Sbjct: 164 LKSRSPHLDDCSKTDHRAKSDVSKDVHHSTSLPNLEKEGKPHSDKRSTSHLPTSVEKHCT 223

Query: 311 KGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSSTEERHLNCGEKGIQKGVS 370
            G  S    +   G S       ++D   G K+ + S  +  TE        K +  G  
Sbjct: 224 NGVWSRSHYQVGEGSS-------NEDSRRGRKDIRHSQFNRGTER-----VRKDLSTGCG 271

Query: 371 KGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTE---------ERRLNSG 421
            G   I    Q         R+    ++YG  E K   +SS  +         ER  +S 
Sbjct: 272 DGEPRILEASQ---------RLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSW 322

Query: 422 EKDVQKGVSKGSISIQTEEKIHGKSQ-----NQVTIPSQDQEH----------------- 459
           EK+     S   +  Q+++K+  +S+     N+  + SQD+E                  
Sbjct: 323 EKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHW 382

Query: 460 --------GHKENKMSYQSSST----EERRLNYGGKSTQKDVSQSSISFQIEKLVEGKSQ 507
                    H +N++++  +S+    EERR   G +  ++D S +S SFQ  +     S 
Sbjct: 383 RRSERASLPHSKNEITFSHNSSKYHLEERR---GWEDCKRDKSVNSHSFQDGRCPSSLSN 439

Query: 508 IQTPNPNQD--------QWSGQNAKGKSGQSADSKQDLLSHEQKGRYKQESSESHNIVIT 559
            +T + N D        QW     K +  ++ D ++     EQ+ + +     +   V T
Sbjct: 440 SRT-HKNIDSKEVDAMHQWENTPLKAERHRTEDKRK----REQESKEENRHIRNEKRVPT 494

Query: 560 EH 561
           EH
Sbjct: 495 EH 496



 Score = 39.7 bits (91), Expect = 0.008
 Identities = 92/436 (21%), Positives = 164/436 (37%), Gaps = 82/436 (18%)

Query: 37  SQFPHGQKGQHYFGQKDQQHTKSKGSFSIQHTYHVDINDHDWTRKSQQYDLNALHKATKS 96
           S+FPH +         D   TK   S S     H+D           + D  A    +K 
Sbjct: 141 SEFPHFRNNHKTARTFDTVKTKDLKSRSP----HLD--------DCSKTDHRAKSDVSKD 188

Query: 97  KQHLGGSQQLLNYKQEGRDHDKSKGHFHM---IVIHHKGG-------QAHHGTQNPSQ-- 144
             H   S  L N ++EG+ H   +   H+   +  H   G       Q   G+ N     
Sbjct: 189 VHH---STSLPNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSNEDSRR 245

Query: 145 ----------DQGNSPSGKGLSSQCSNTEKRLWVHGLSKEQASASGAQKGRTQGGSQSSY 194
                     ++G     K LS+ C + E R+ +    + Q       KG  +  S+SS 
Sbjct: 246 GRKDIRHSQFNRGTERVRKDLSTGCGDGEPRI-LEASQRLQGHPEKYGKGEPKTESKSSK 304

Query: 195 VLQTEELVVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHPAHQDRLQHGPKDIF 254
                +     ++  +    +  G   +   V  +   KL+        +R Q+  +   
Sbjct: 305 FKSNSDSDYKGERINSSWEKETPGERSHS-RVDSQSDKKLERQ-----SERSQNINRKEV 358

Query: 255 TTQDELLVYNKNQHQTKNLSQDQEHGRKAHKISYPSSRTEERQLHHGEK----------S 304
            +QD+     K   + K++ +DQ+H R++ + S P S+ E    H+  K           
Sbjct: 359 KSQDK--EERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWED 416

Query: 305 VQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSST---EERHLNCG 361
            ++D S  S S Q      G+  + ++     +    KE    +Q  +T    ERH    
Sbjct: 417 CKRDKSVNSHSFQ-----DGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERH-RTE 470

Query: 362 EKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEERRLNSG 421
           +K  ++  SK       EE  H   +N+ R+P++  +  +KE K     ++T+ ++ N  
Sbjct: 471 DKRKREQESK-------EENRH--IRNEKRVPTEHLQKTNKETK----KTTTDLKKQNEP 517

Query: 422 EKD----VQKGVSKGS 433
           + D    +  GVS+G+
Sbjct: 518 KTDKGEVLDNGVSEGA 533


>gi|6912288 caspase 8 associated protein 2 [Homo sapiens]
          Length = 1982

 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 88/422 (20%), Positives = 160/422 (37%), Gaps = 94/422 (22%)

Query: 193 SYVLQTEELVVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHPAHQDRLQHGPKD 252
           S +++T  + +N++  E  N HQ    + +    R  H +           D ++   KD
Sbjct: 116 SALIKTARVEINRKDEEISNLHQRLSEFPH---FRNNHKTARTF-------DTVK--TKD 163

Query: 253 IFTTQDELLVYNKNQHQTK-NLSQDQEHGRKAHKISYPSS-RTEERQLHHGEKSVQKDVS 310
           + +    L   +K  H+ K ++S+D  H      +       +++R   H   SV+K  +
Sbjct: 164 LKSRSPHLDDCSKTDHRAKSDVSKDVHHSTSLPNLEKEGKPHSDKRSTSHLPTSVEKHCT 223

Query: 311 KGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSSTEERHLNCGEKGIQKGVS 370
            G  S    +   G S       ++D   G K+ + S  +  TE        K +  G  
Sbjct: 224 NGVWSRSHYQVGEGSS-------NEDSRRGRKDIRHSQFNRGTER-----VRKDLSTGCG 271

Query: 371 KGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTE---------ERRLNSG 421
            G   I    Q         R+    ++YG  E K   +SS  +         ER  +S 
Sbjct: 272 DGEPRILEASQ---------RLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSW 322

Query: 422 EKDVQKGVSKGSISIQTEEKIHGKSQ-----NQVTIPSQDQEH----------------- 459
           EK+     S   +  Q+++K+  +S+     N+  + SQD+E                  
Sbjct: 323 EKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHW 382

Query: 460 --------GHKENKMSYQSSST----EERRLNYGGKSTQKDVSQSSISFQIEKLVEGKSQ 507
                    H +N++++  +S+    EERR   G +  ++D S +S SFQ  +     S 
Sbjct: 383 RRSERASLPHSKNEITFSHNSSKYHLEERR---GWEDCKRDKSVNSHSFQDGRCPSSLSN 439

Query: 508 IQTPNPNQD--------QWSGQNAKGKSGQSADSKQDLLSHEQKGRYKQESSESHNIVIT 559
            +T + N D        QW     K +  ++ D ++     EQ+ + +     +   V T
Sbjct: 440 SRT-HKNIDSKEVDAMHQWENTPLKAERHRTEDKRK----REQESKEENRHIRNEKRVPT 494

Query: 560 EH 561
           EH
Sbjct: 495 EH 496



 Score = 39.7 bits (91), Expect = 0.008
 Identities = 92/436 (21%), Positives = 164/436 (37%), Gaps = 82/436 (18%)

Query: 37  SQFPHGQKGQHYFGQKDQQHTKSKGSFSIQHTYHVDINDHDWTRKSQQYDLNALHKATKS 96
           S+FPH +         D   TK   S S     H+D           + D  A    +K 
Sbjct: 141 SEFPHFRNNHKTARTFDTVKTKDLKSRSP----HLD--------DCSKTDHRAKSDVSKD 188

Query: 97  KQHLGGSQQLLNYKQEGRDHDKSKGHFHM---IVIHHKGG-------QAHHGTQNPSQ-- 144
             H   S  L N ++EG+ H   +   H+   +  H   G       Q   G+ N     
Sbjct: 189 VHH---STSLPNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSNEDSRR 245

Query: 145 ----------DQGNSPSGKGLSSQCSNTEKRLWVHGLSKEQASASGAQKGRTQGGSQSSY 194
                     ++G     K LS+ C + E R+ +    + Q       KG  +  S+SS 
Sbjct: 246 GRKDIRHSQFNRGTERVRKDLSTGCGDGEPRI-LEASQRLQGHPEKYGKGEPKTESKSSK 304

Query: 195 VLQTEELVVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHPAHQDRLQHGPKDIF 254
                +     ++  +    +  G   +   V  +   KL+        +R Q+  +   
Sbjct: 305 FKSNSDSDYKGERINSSWEKETPGERSHS-RVDSQSDKKLERQ-----SERSQNINRKEV 358

Query: 255 TTQDELLVYNKNQHQTKNLSQDQEHGRKAHKISYPSSRTEERQLHHGEK----------S 304
            +QD+     K   + K++ +DQ+H R++ + S P S+ E    H+  K           
Sbjct: 359 KSQDK--EERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWED 416

Query: 305 VQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSST---EERHLNCG 361
            ++D S  S S Q      G+  + ++     +    KE    +Q  +T    ERH    
Sbjct: 417 CKRDKSVNSHSFQ-----DGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERH-RTE 470

Query: 362 EKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEERRLNSG 421
           +K  ++  SK       EE  H   +N+ R+P++  +  +KE K     ++T+ ++ N  
Sbjct: 471 DKRKREQESK-------EENRH--IRNEKRVPTEHLQKTNKETK----KTTTDLKKQNEP 517

Query: 422 EKD----VQKGVSKGS 433
           + D    +  GVS+G+
Sbjct: 518 KTDKGEVLDNGVSEGA 533


>gi|212549532 caspase 8 associated protein 2 [Homo sapiens]
          Length = 1982

 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 88/422 (20%), Positives = 160/422 (37%), Gaps = 94/422 (22%)

Query: 193 SYVLQTEELVVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHPAHQDRLQHGPKD 252
           S +++T  + +N++  E  N HQ    + +    R  H +           D ++   KD
Sbjct: 116 SALIKTARVEINRKDEEISNLHQRLSEFPH---FRNNHKTARTF-------DTVK--TKD 163

Query: 253 IFTTQDELLVYNKNQHQTK-NLSQDQEHGRKAHKISYPSS-RTEERQLHHGEKSVQKDVS 310
           + +    L   +K  H+ K ++S+D  H      +       +++R   H   SV+K  +
Sbjct: 164 LKSRSPHLDDCSKTDHRAKSDVSKDVHHSTSLPNLEKEGKPHSDKRSTSHLPTSVEKHCT 223

Query: 311 KGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSSTEERHLNCGEKGIQKGVS 370
            G  S    +   G S       ++D   G K+ + S  +  TE        K +  G  
Sbjct: 224 NGVWSRSHYQVGEGSS-------NEDSRRGRKDIRHSQFNRGTER-----VRKDLSTGCG 271

Query: 371 KGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTE---------ERRLNSG 421
            G   I    Q         R+    ++YG  E K   +SS  +         ER  +S 
Sbjct: 272 DGEPRILEASQ---------RLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSW 322

Query: 422 EKDVQKGVSKGSISIQTEEKIHGKSQ-----NQVTIPSQDQEH----------------- 459
           EK+     S   +  Q+++K+  +S+     N+  + SQD+E                  
Sbjct: 323 EKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHW 382

Query: 460 --------GHKENKMSYQSSST----EERRLNYGGKSTQKDVSQSSISFQIEKLVEGKSQ 507
                    H +N++++  +S+    EERR   G +  ++D S +S SFQ  +     S 
Sbjct: 383 RRSERASLPHSKNEITFSHNSSKYHLEERR---GWEDCKRDKSVNSHSFQDGRCPSSLSN 439

Query: 508 IQTPNPNQD--------QWSGQNAKGKSGQSADSKQDLLSHEQKGRYKQESSESHNIVIT 559
            +T + N D        QW     K +  ++ D ++     EQ+ + +     +   V T
Sbjct: 440 SRT-HKNIDSKEVDAMHQWENTPLKAERHRTEDKRK----REQESKEENRHIRNEKRVPT 494

Query: 560 EH 561
           EH
Sbjct: 495 EH 496



 Score = 39.7 bits (91), Expect = 0.008
 Identities = 92/436 (21%), Positives = 164/436 (37%), Gaps = 82/436 (18%)

Query: 37  SQFPHGQKGQHYFGQKDQQHTKSKGSFSIQHTYHVDINDHDWTRKSQQYDLNALHKATKS 96
           S+FPH +         D   TK   S S     H+D           + D  A    +K 
Sbjct: 141 SEFPHFRNNHKTARTFDTVKTKDLKSRSP----HLD--------DCSKTDHRAKSDVSKD 188

Query: 97  KQHLGGSQQLLNYKQEGRDHDKSKGHFHM---IVIHHKGG-------QAHHGTQNPSQ-- 144
             H   S  L N ++EG+ H   +   H+   +  H   G       Q   G+ N     
Sbjct: 189 VHH---STSLPNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSNEDSRR 245

Query: 145 ----------DQGNSPSGKGLSSQCSNTEKRLWVHGLSKEQASASGAQKGRTQGGSQSSY 194
                     ++G     K LS+ C + E R+ +    + Q       KG  +  S+SS 
Sbjct: 246 GRKDIRHSQFNRGTERVRKDLSTGCGDGEPRI-LEASQRLQGHPEKYGKGEPKTESKSSK 304

Query: 195 VLQTEELVVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHPAHQDRLQHGPKDIF 254
                +     ++  +    +  G   +   V  +   KL+        +R Q+  +   
Sbjct: 305 FKSNSDSDYKGERINSSWEKETPGERSHS-RVDSQSDKKLERQ-----SERSQNINRKEV 358

Query: 255 TTQDELLVYNKNQHQTKNLSQDQEHGRKAHKISYPSSRTEERQLHHGEK----------S 304
            +QD+     K   + K++ +DQ+H R++ + S P S+ E    H+  K           
Sbjct: 359 KSQDK--EERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWED 416

Query: 305 VQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSST---EERHLNCG 361
            ++D S  S S Q      G+  + ++     +    KE    +Q  +T    ERH    
Sbjct: 417 CKRDKSVNSHSFQ-----DGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERH-RTE 470

Query: 362 EKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEERRLNSG 421
           +K  ++  SK       EE  H   +N+ R+P++  +  +KE K     ++T+ ++ N  
Sbjct: 471 DKRKREQESK-------EENRH--IRNEKRVPTEHLQKTNKETK----KTTTDLKKQNEP 517

Query: 422 EKD----VQKGVSKGS 433
           + D    +  GVS+G+
Sbjct: 518 KTDKGEVLDNGVSEGA 533


>gi|57864582 hornerin [Homo sapiens]
          Length = 2850

 Score = 50.1 bits (118), Expect = 6e-06
 Identities = 125/576 (21%), Positives = 193/576 (33%), Gaps = 77/576 (13%)

Query: 25  KGGSKGQLPSGSSQFP-HGQKGQ----------HYFGQKD----QQHTKSKGSFSIQHTY 69
           +   +GQ  SGS Q P +GQ G           H  G        QH  S G  S  ++ 
Sbjct: 188 QSSGRGQCGSGSGQSPNYGQHGSGSGQSSSNDTHGSGSGQSSGFSQHKSSSGQ-SSGYSQ 246

Query: 70  HVDINDH-----DWTRKSQQYDLNALHKATKSK-----QHLGGSQQLLNYKQEGRDHDKS 119
           H   + H         +S Q      H+++        QH  GS+Q L + ++G    +S
Sbjct: 247 HGSGSGHSSGYGQHGSRSGQSSRGERHRSSSGSSSSYGQHGSGSRQSLGHGRQGSGSRQS 306

Query: 120 KGHF-HMIVIHHKGGQAHHGT-QNPSQDQGNSPSGKGLSSQCSNTEKRLWVHGLSKEQAS 177
             H  H     H      HG+  + S  +G+  SG G +S     E          +  S
Sbjct: 307 PSHVRHGSGSGHSSSHGQHGSGSSYSYSRGHYESGSGQTSGFGQHESGSGQSSGYSKHGS 366

Query: 178 ASGAQKGRTQGGSQSSYVLQTEELVVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTS 237
            SG    + Q GS S     + +   + +Q  +   H++   + +    R +HSS    S
Sbjct: 367 GSGHSSSQGQHGSTSGQASSSGQHGSSSRQSSSYGQHESASRHSS---GRGQHSSGSGQS 423

Query: 238 LHPAHQDRLQHGPKDIFTTQDELLVYNKNQHQTKNLSQDQEHGRKAHKISYPSSRTEERQ 297
             P H  R     +            +  QH T         GR +    Y S       
Sbjct: 424 --PGHGQRGSGSGQS----------PSSGQHGT-------GFGRSSSSGPYVSGSGYSSG 464

Query: 298 LHHGEKSVQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSSTEERH 357
             H E S     S+ S          G S       S+  +    E + S   SS+    
Sbjct: 465 FGHHESS-----SEHSSGYTQHGSGSGHSSGHGQHGSRSGQSSRGERQGSSAGSSSSYGQ 519

Query: 358 LNCGEKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKIS----YQSSST 413
              G +        GS S Q+     G+ ++  R  S    +G+   + S    Y+S S 
Sbjct: 520 HGSGSRQSLGHSRHGSGSGQSPSPSRGRHESGSRQSSSYGPHGYGSGRSSSRGPYESGSG 579

Query: 414 EERRLNSGEKDVQKGVSKG---SISIQTEEKIHGKSQNQVTIPSQDQEHGHKENKMS--- 467
               L  G ++ + G S G     S       HG+  +     S   +HG    + S   
Sbjct: 580 HSSGL--GHQESRSGQSSGYGQHGSSSGHSSTHGQHGSTSGQSSSCGQHGATSGQSSSHG 637

Query: 468 -YQSSSTEERRLNYGGKSTQKDVSQS--------SISFQIEKLVEGKSQIQTPNPN-QDQ 517
            + S S++  R    G  + +  S+         S S+       G S    P+ +   Q
Sbjct: 638 QHGSGSSQSSRYGQQGSGSGQSPSRGRHGSDFGHSSSYGQHGSGSGWSSSNGPHGSVSGQ 697

Query: 518 WSGQNAKGKSGQSADSKQDLLSHEQKGRYKQESSES 553
            SG   K  SGQS+   Q          Y++  S S
Sbjct: 698 SSGFGHKSGSGQSSGYSQHGSGSSHSSGYRKHGSRS 733



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 131/603 (21%), Positives = 195/603 (32%), Gaps = 102/603 (16%)

Query: 17   KQAAVMGQKGGSKGQLPS------------GSSQFPHGQ-------KGQHYFGQKDQQ-- 55
            +Q+   GQ G   GQ PS             SS  P+G        +G +  G       
Sbjct: 1461 RQSLGHGQHGSGSGQSPSPSRGRHGSGSGQSSSYSPYGSGSGWSSSRGPYESGSSHSSGL 1520

Query: 56   -HTKSKGSFSIQHTYHVDINDHDWTR-----KSQQYDLNALHKATKSK-----QHLGGSQ 104
             H +S+   S  +  H   + H  T       S Q      H A+  +     QH  GS 
Sbjct: 1521 GHRESRSGQSSGYGQHGSSSGHSSTHGQHGSTSGQSSSCGQHGASSGQSSSHGQHGSGSS 1580

Query: 105  QLLNYKQEGRDHDKSKGHFHM-IVIHHKGGQAHHGT-QNPSQDQGNSPSGKGLSSQCSNT 162
            Q   Y ++G    +S GH               HG+    S   G   SG G SS   + 
Sbjct: 1581 QSSGYGRQGSGSGQSPGHGQRGSGSRQSPSYGRHGSGSGRSSSSGQHGSGLGESSGFGHH 1640

Query: 163  EKRLWVHGLSKEQASASGAQKGRTQGGSQSSYVLQTEELVVNKQQRETKNSH-----QNK 217
            E          +  S SG   G  Q GS+S    + E    + +       H     Q+ 
Sbjct: 1641 ESSSGQSSSYSQHGSGSGHSSGYGQHGSRSGQSSRGERHGSSSRSSSRYGQHGSGSRQSS 1700

Query: 218  GHYQ-----NVVDVREEHSSKL-QTSLHPAHQD----RLQHGPKDIFTTQDELLVYNKNQ 267
            GH +          R  H S L  +S H  H          GP +  +      V+ +++
Sbjct: 1701 GHGRQGSGSGQSPSRGRHGSGLGHSSSHGQHGSGSGRSSSRGPYE--SRSGHSSVFGQHE 1758

Query: 268  HQTKNLSQDQEHGR-KAHKISYPSSRTEERQLHHGEKSVQK---DVSKGSISIQTEEKIH 323
              + + S   +HG    H  S         Q  HG  S Q    D    S    +    H
Sbjct: 1759 SGSGHSSAYSQHGSGSGHFCS---------QGQHGSTSGQSSTFDQEGSSTGQSSSHGQH 1809

Query: 324  GKSQNQVTIHSQDQEHGHKENKISYQSSSTEERHLNCGEKGIQKGVSKGSISIQTEEQIH 383
            G   +Q + + Q Q  G  ++    +  S      + G+ G   G S  S         H
Sbjct: 1810 GSGSSQSSSYGQ-QGSGSGQSPSRGRHGSGSGHSSSYGQHGSGSGWSSSS-------GRH 1861

Query: 384  GKSQNQVRIPSQAQEYGHKENKISYQSSSTEERRLNSGEKDVQKGVSKGSISIQTEEKIH 443
            G          Q+  +GH E+  S+QSS   +    SG                +  + H
Sbjct: 1862 GSGS------GQSSGFGHHESS-SWQSSGYTQHGSGSGH--------------SSSYEQH 1900

Query: 444  GKSQNQVTIPSQDQEHGHKENKMSY--QSSSTEERRLNYGGKSTQKDVSQSSISFQIEKL 501
            G    Q    S+ ++HG      S   Q  S   + L +G   +    S S  S      
Sbjct: 1901 GSRSGQ---SSRGEQHGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSP-SRGRHGS 1956

Query: 502  VEGKSQIQTPNPNQDQWSGQNAKGKSGQSADS---KQDLLSHEQKGRYKQESSESHNIVI 558
              G+S    P  +   WS      +SG    S    ++  S +  G  +  SS  H+   
Sbjct: 1957 GSGQSSSYGPYGSGSGWSSSRGPYESGSGHSSGLGHRESRSGQSSGYGQHGSSSGHSSTH 2016

Query: 559  TEH 561
             +H
Sbjct: 2017 GQH 2019



 Score = 46.6 bits (109), Expect = 6e-05
 Identities = 130/573 (22%), Positives = 189/573 (32%), Gaps = 79/573 (13%)

Query: 23  GQKGGSKGQLPSGSSQFP----HGQKGQHYFGQKDQQHTKSKGSFSIQHTYHVDINDHDW 78
           GQ  G  GQ  SGS Q      HG    H   Q     T  + S S QH           
Sbjct: 343 GQTSGF-GQHESGSGQSSGYSKHGSGSGHSSSQGQHGSTSGQASSSGQHGSS-------- 393

Query: 79  TRKSQQYDLN--ALHKATKSKQHLGGSQQLLNYKQEGRDHDKSKGHFHMIVIHHKGGQAH 136
           +R+S  Y  +  A   ++   QH  GS Q   + Q G    +S                 
Sbjct: 394 SRQSSSYGQHESASRHSSGRGQHSSGSGQSPGHGQRGSGSGQSPS------------SGQ 441

Query: 137 HGTQ-NPSQDQGNSPSGKGLSSQCSNTEKRLWVHGLSKEQASASGAQKGRTQGGSQSSYV 195
           HGT    S   G   SG G SS   + E          +  S SG   G  Q GS+S   
Sbjct: 442 HGTGFGRSSSSGPYVSGSGYSSGFGHHESSSEHSSGYTQHGSGSGHSSGHGQHGSRSGQS 501

Query: 196 LQTEELVVNKQQRETKNSH-----QNKGHY-------QNVVDVREEHSS-KLQTSLHPAH 242
            + E    +     +   H     Q+ GH        Q+    R  H S   Q+S +  H
Sbjct: 502 SRGERQGSSAGSSSSYGQHGSGSRQSLGHSRHGSGSGQSPSPSRGRHESGSRQSSSYGPH 561

Query: 243 Q----DRLQHGPKDIFTTQDELLVYNKNQHQTKNLSQDQEHGRKAHKISYPSSRTEERQL 298
                     GP +  +     L      HQ     Q   +G+      + S+  +    
Sbjct: 562 GYGSGRSSSRGPYESGSGHSSGL-----GHQESRSGQSSGYGQHGSSSGHSSTHGQ---- 612

Query: 299 HHGEKSVQKDV--SKGSISIQTEEK-IHGKSQNQVTIHSQDQEHGHKENKISYQSSSTEE 355
            HG  S Q       G+ S Q+     HG   +Q + + Q Q  G  ++    +  S   
Sbjct: 613 -HGSTSGQSSSCGQHGATSGQSSSHGQHGSGSSQSSRYGQ-QGSGSGQSPSRGRHGSDFG 670

Query: 356 RHLNCGEKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEE 415
              + G+ G   G S  +        + G+S          Q  G+ ++      SS   
Sbjct: 671 HSSSYGQHGSGSGWSSSN---GPHGSVSGQSSGFGHKSGSGQSSGYSQHGSGSSHSSGYR 727

Query: 416 R---RLNSGEKDVQKGVSKGSISIQTEEKIHGKSQNQVTIPS-QDQEHGHKENKMSYQSS 471
           +   R     +  Q G S G  S   +   HG   +Q +    Q    GH  +++ + SS
Sbjct: 728 KHGSRSGQSSRSEQHGSSSGLSSSYGQ---HGSGSHQSSGHGRQGSGSGHSPSRVRHGSS 784

Query: 472 STEERRLNYGGKSTQ--------KDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQNA 523
           S         G  T         +  S  +  F   +   G+   Q  + +   +S Q  
Sbjct: 785 SGHSSSHGQHGSGTSCSSSCGHYESGSGQASGFGQHESGSGQGYSQHGSAS-GHFSSQGR 843

Query: 524 KGK-SGQSADSKQDLLSHEQKGRYKQESSESHN 555
            G  SGQS+ S Q   S  Q   Y Q  S SH+
Sbjct: 844 HGSTSGQSSSSGQHDSSSGQSSSYGQHESASHH 876



 Score = 46.2 bits (108), Expect = 8e-05
 Identities = 122/551 (22%), Positives = 174/551 (31%), Gaps = 98/551 (17%)

Query: 23  GQKGGSKGQLP----SGSSQFPHGQKGQHYFGQKDQQHTKSKGSFSIQHTYHVDINDHDW 78
           GQ G   GQ       GSS       GQH  G +        GS S Q            
Sbjct: 492 GQHGSRSGQSSRGERQGSSAGSSSSYGQHGSGSRQSLGHSRHGSGSGQSPSPSRGRHESG 551

Query: 79  TRKSQQYDLNALHKATKSKQHLGGSQQLLNYKQEGRDHDKSKGHFHMIVIHHKGGQAHHG 138
           +R+S  Y  +       S +            + G  H    GH         G   H  
Sbjct: 552 SRQSSSYGPHGYGSGRSSSR---------GPYESGSGHSSGLGHQESRSGQSSGYGQHGS 602

Query: 139 TQNPSQDQGNSPSGKGLSSQCSNTEKRLWVHGLSKEQASASGAQKGRTQGGSQSSYVLQT 198
           +   S   G   S  G SS C         HG +  Q+S+ G      Q GS SS   + 
Sbjct: 603 SSGHSSTHGQHGSTSGQSSSCGQ-------HGATSGQSSSHG------QHGSGSSQSSRY 649

Query: 199 EELVVNKQQRETKNSHQNK-GHYQNVVDVREEHSSKLQTSLHPAHQDRLQHGPKDIFTTQ 257
            +      Q  ++  H +  GH  +      +H S    S          +GP    + Q
Sbjct: 650 GQQGSGSGQSPSRGRHGSDFGHSSSY----GQHGSGSGWSS--------SNGPHGSVSGQ 697

Query: 258 DELLVYNKNQHQTKNLSQDQEHGR-KAHKISYPSSRTEERQLHHGEKSVQKDVSK---GS 313
                +     Q+   SQ   HG   +H   Y           HG +S Q   S+    S
Sbjct: 698 SSGFGHKSGSGQSSGYSQ---HGSGSSHSSGYRK---------HGSRSGQSSRSEQHGSS 745

Query: 314 ISIQTEEKIHGKSQNQVTIHS-QDQEHGHKENKISYQSSSTEERHLNCGEKGIQKGVSKG 372
             + +    HG   +Q + H  Q    GH  +++ + SSS                    
Sbjct: 746 SGLSSSYGQHGSGSHQSSGHGRQGSGSGHSPSRVRHGSSSGHSSS--------------- 790

Query: 373 SISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEERRLNSGEKDVQKGVSKG 432
                     HG+  +     S     GH E+  S Q+S   +    SG+   Q G + G
Sbjct: 791 ----------HGQHGSGTSCSSSC---GHYESG-SGQASGFGQHESGSGQGYSQHGSASG 836

Query: 433 SISIQTEEKIHGKSQNQVTIPSQ-DQEHGHKENKMSYQSSSTEER-RLNYGGKSTQK--- 487
             S Q     HG +  Q +   Q D   G   +   ++S+S     R  +G  S Q    
Sbjct: 837 HFSSQGR---HGSTSGQSSSSGQHDSSSGQSSSYGQHESASHHASGRGRHGSGSGQSPGH 893

Query: 488 ----DVSQSSISFQIEKLVEGKSQIQTPNPN-QDQWSGQNAKGKSGQSADSKQDLLSHEQ 542
                 S  S S+       G+S     + +   Q SG   K  SGQS+   Q       
Sbjct: 894 GQRGSGSGQSPSYGRHGSGSGRSSSSGRHGSGSGQSSGFGHKSSSGQSSGYTQHGSGSGH 953

Query: 543 KGRYKQESSES 553
              Y+Q  S S
Sbjct: 954 SSSYEQHGSRS 964



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 129/591 (21%), Positives = 196/591 (33%), Gaps = 105/591 (17%)

Query: 23   GQKGGSKGQLPS----------GSSQFPHGQKGQHYFGQKDQQHTKSKGSFSIQHTYHVD 72
            G+ G   GQ  S           SS+ P+     H  G     H +S+   S  +  H  
Sbjct: 1012 GRHGSGSGQSSSYGPYRSGSGWSSSRGPYESGSGHSSGLG---HRESRSGQSSGYGQHGS 1068

Query: 73   INDHDWTR-----KSQQYDLNALHKATKSK-----QHLGGSQQLLNYKQEGRDHDKSKGH 122
             + H  T       S Q      H A+  +     QH  GS Q   Y ++G    +S GH
Sbjct: 1069 SSGHSSTHGQHGSTSGQSSSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQGSGSGQSPGH 1128

Query: 123  FHMIVIHHKGGQAHHGTQNPSQDQGNSPSGKGLSSQCSNT---EKRLWVHGLSKEQASAS 179
                     G +     Q+PS  +  S SG+  SS    +   E   + H  S    S+S
Sbjct: 1129 ---------GQRGSGSRQSPSYGRHGSGSGRSSSSGQHGSGLGESSGFGHHESSSGQSSS 1179

Query: 180  GAQKGRTQGGSQSSYVLQTEELVVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLH 239
             +Q G   G S S Y         + +     +S  +  HY       +  S   Q+S H
Sbjct: 1180 YSQHGSGSGHS-SGYGQHGSRSGQSSRGERHGSSSGSSSHY------GQHGSGSRQSSGH 1232

Query: 240  PAHQDRLQHGPKDIFTTQDELLVYNKNQHQTKNLSQDQEHGRKAHKISYPSSR-TEERQL 298
                    H P             ++ +H +  L     HG+        SSR   E + 
Sbjct: 1233 GRQGSGSGHSP-------------SRGRHGS-GLGHSSSHGQHGSGSGRSSSRGPYESRS 1278

Query: 299  HHGEKSVQKDVSKGSISIQTE----------EKIHGKSQNQVTIHSQD-------QEHGH 341
             H     Q +   G  S  ++          +  HG +  Q +   Q+         +GH
Sbjct: 1279 GHSSVFGQHESGSGHSSAYSQHGSGSGHFCSQGQHGSTSGQSSTFDQEGSSTGQSSSYGH 1338

Query: 342  KENKISYQSSSTEERHLNCGE---KGIQKGVSKGSISIQTEEQIHGKSQNQVRIPS---Q 395
            + +  S QSS         G+   +G     S  S S        G S +  R  S   Q
Sbjct: 1339 RGSG-SSQSSGYGRHGAGSGQSPSRGRHGSGSGHSSSYGQHGSGSGWSSSSGRHGSGSGQ 1397

Query: 396  AQEYGHKENKISYQSSSTEERRLNSGEKDVQKGVSKGSISIQTEEKIHGKSQNQVTIPSQ 455
            +  +GH E+  S+QSS   +    SG                +  + HG    Q    S+
Sbjct: 1398 SSGFGHHESS-SWQSSGCTQHGSGSGH--------------SSSYEQHGSRSGQ---SSR 1439

Query: 456  DQEHGHKENKMSY--QSSSTEERRLNYGGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNP 513
             + HG      S   Q  S   + L +G   +    S S  S        G+S   +P  
Sbjct: 1440 GERHGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSP-SRGRHGSGSGQSSSYSPYG 1498

Query: 514  NQDQWSGQNAKGKSGQSADS---KQDLLSHEQKGRYKQESSESHNIVITEH 561
            +   WS      +SG S  S    ++  S +  G  +  SS  H+    +H
Sbjct: 1499 SGSGWSSSRGPYESGSSHSSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQH 1549



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 130/601 (21%), Positives = 204/601 (33%), Gaps = 98/601 (16%)

Query: 17   KQAAVMGQKGGSKGQLPS------------GSSQFPHGQ-------KGQHYFGQKDQQ-- 55
            +Q+   GQ G   GQ PS             SS  P+G        +G +  G       
Sbjct: 1931 RQSLGHGQHGSGSGQSPSPSRGRHGSGSGQSSSYGPYGSGSGWSSSRGPYESGSGHSSGL 1990

Query: 56   -HTKSKGSFSIQHTYHVDINDHDWTR-----KSQQYDLNALHKATKSK-----QHLGGSQ 104
             H +S+   S  +  H   + H  T       S Q      H A+  +     QH  GS 
Sbjct: 1991 GHRESRSGQSSGYGQHGSSSGHSSTHGQHGSASGQSSSCGQHGASSGQSSSHGQHGSGSS 2050

Query: 105  QLLNYKQEGRDHDKSKGHFHMIVIHHKGGQAHHGTQNPSQDQGNSPSGKGLSSQCSNT-- 162
            Q   Y ++G    +S GH         G +     Q+PS  +  S SG+  SS       
Sbjct: 2051 QSSGYGRQGSGSGQSPGH---------GQRGSGSRQSPSYGRHGSGSGRSSSSGQHGPGL 2101

Query: 163  -EKRLWVHGLSKEQASASGAQKGRTQGGSQSSYVLQTEELVVNKQQRETKNSHQNKGHYQ 221
             E   + H  S    S+S +Q G   G S       +     ++ +R   +S  +  + Q
Sbjct: 2102 GESSGFGHHESSSGQSSSYSQHGSGSGHSSGYGQHGSRSGQSSRGERHGSSSGSSSRYGQ 2161

Query: 222  NVVDVREEHSSKLQTSLHPAHQDRLQHGPKDIFTTQDELLVYNKNQHQT---KNLSQDQE 278
            +    R+      Q S       R +HG     ++       +  QH +   ++ S+   
Sbjct: 2162 HGSGSRQSSGHGRQGSGSGHSPSRGRHGSGSGHSS-------SHGQHGSGSGRSSSRGPY 2214

Query: 279  HGRKAHKISYPSSRTEERQLHHGEKSVQKDVSKGSISIQTEEKIHGKSQNQVTIHSQD-- 336
              R  H     SS   + +   G  S       GS    ++ + HG +  Q +   Q+  
Sbjct: 2215 ESRSGH-----SSVFGQHESGSGHSSAYSQHGSGSGHFCSQGQ-HGSTSGQSSTFDQEGS 2268

Query: 337  -----QEHGHKENKISYQSSSTEERHLNCGE---KGIQKGVSKGSISIQTEEQIHGKSQN 388
                   HG +    S QSSS  ++    G+   +G     S  S S        G S +
Sbjct: 2269 STGQSSSHG-QHGSGSSQSSSYGQQGSGSGQSPSRGRHGSGSGHSSSYGQHGSGSGWSSS 2327

Query: 389  QVRIPS---QAQEYGHKENKISYQSSSTEERRLNSGEKDVQKGVSKGSISIQTEEKIHGK 445
              R  S   Q+  +GH E+  S+QSS   +    SG                +  + HG 
Sbjct: 2328 SGRHGSGSGQSSGFGHHESS-SWQSSGYTQHGSGSGH--------------SSSYEQHGS 2372

Query: 446  SQNQVTIPSQDQEHGHKENKMSY--QSSSTEERRLNYGGKSTQKDVSQSSISFQIEKLVE 503
               Q    S+ + HG      S   Q  S   + L +G   +    S S  S        
Sbjct: 2373 RSGQ---SSRGERHGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSP-SRGRHGSGS 2428

Query: 504  GKSQIQTPNPNQDQWSGQNAKGKSGQSADS---KQDLLSHEQKGRYKQESSESHNIVITE 560
            G+S   +P  +   WS      +SG    S    ++  S +  G  +  SS  H+    +
Sbjct: 2429 GQSSSYSPYGSGSGWSSSRGPYESGSGHSSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQ 2488

Query: 561  H 561
            H
Sbjct: 2489 H 2489



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 119/585 (20%), Positives = 187/585 (31%), Gaps = 72/585 (12%)

Query: 23   GQKGGSKGQLPS----GSSQFPHGQKGQHYFGQKDQQ---HTKSKGSFSIQHTYHVDIND 75
            GQ+G   GQ PS    GS        G+H  G        H  S G  S  +T H   + 
Sbjct: 894  GQRGSGSGQSPSYGRHGSGSGRSSSSGRHGSGSGQSSGFGHKSSSGQSS-GYTQHGSGSG 952

Query: 76   HDWTRKSQQYDLNALHKATKSKQHLGGSQQLLNYKQEGRDHDKSKGHFH----------M 125
            H     S +   +   ++++S+QH   S    +Y Q G    +S GH             
Sbjct: 953  HS---SSYEQHGSRSGQSSRSEQHGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSP 1009

Query: 126  IVIHHKGGQAHHGTQNP-------SQDQGNSPSGKGLSSQCSNTEKR------LWVHGLS 172
                H  G     +  P       S  +G   SG G SS   + E R         HG S
Sbjct: 1010 SRGRHGSGSGQSSSYGPYRSGSGWSSSRGPYESGSGHSSGLGHRESRSGQSSGYGQHGSS 1069

Query: 173  KEQASASG------------AQKGRTQGGSQSSYVLQTEELVVNKQQRETKNSHQNKGHY 220
               +S  G             Q G + G S S     +     +   R+   S Q+ GH 
Sbjct: 1070 SGHSSTHGQHGSTSGQSSSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQGSGSGQSPGHG 1129

Query: 221  QNVVDVREEHSSKLQTSLHPAHQDRLQHGPKDIFTTQDELLVYNKNQHQTKNLSQDQEHG 280
            Q     R+  S     S         QHG     +   E   +  ++  +   S   +HG
Sbjct: 1130 QRGSGSRQSPSYGRHGSGSGRSSSSGQHG-----SGLGESSGFGHHESSSGQSSSYSQHG 1184

Query: 281  R-KAHKISYPSSRTEERQLHHGEKSVQKDVSKGSISIQTEEKIHGKSQNQVTIHS-QDQE 338
                H   Y    +   Q   GE+      S GS S   +   HG    Q + H  Q   
Sbjct: 1185 SGSGHSSGYGQHGSRSGQSSRGER---HGSSSGSSSHYGQ---HGSGSRQSSGHGRQGSG 1238

Query: 339  HGHKENKISYQSSSTEERHLNCGEKGIQKGVSKGSISIQT-EEQIHGKSQNQVRIPSQAQ 397
             GH  ++  + S             G  +  S+G    ++    + G+ ++     S   
Sbjct: 1239 SGHSPSRGRHGSGLGHSSSHGQHGSGSGRSSSRGPYESRSGHSSVFGQHESGSGHSSAYS 1298

Query: 398  EYGH---------KENKISYQSSSTEERRLNSGEKDVQKGVSKGSISIQTEEKIHGKSQN 448
            ++G          +    S QSS+ ++   ++G+         GS S  +    HG    
Sbjct: 1299 QHGSGSGHFCSQGQHGSTSGQSSTFDQEGSSTGQSSSYGHRGSGS-SQSSGYGRHGAGSG 1357

Query: 449  QVTIPSQDQEHGHKENKMSYQSSSTEERRLNYGGKSTQKDVSQSSISFQIEKLVEGKSQI 508
            Q   PS+ +      +  SY    +     +  G+        S          +     
Sbjct: 1358 Q--SPSRGRHGSGSGHSSSYGQHGSGSGWSSSSGRHGSGSGQSSGFGHHESSSWQSSGCT 1415

Query: 509  QTPNPNQDQWSGQNAKGKSGQSADSKQDLLSHEQKGRYKQESSES 553
            Q  + +    S +    +SGQS+  ++   S      Y Q  S S
Sbjct: 1416 QHGSGSGHSSSYEQHGSRSGQSSRGERHGSSSGSSSSYGQHGSGS 1460



 Score = 39.7 bits (91), Expect = 0.008
 Identities = 125/567 (22%), Positives = 171/567 (30%), Gaps = 117/567 (20%)

Query: 23   GQKGGSKGQLPSGSSQ--FPHGQKGQHYFGQKDQQHTKSKGSFSIQHTYHVDINDHDWTR 80
            GQ  G  GQ  SGS Q    HG    H+  Q     T  + S S QH      +      
Sbjct: 812  GQASGF-GQHESGSGQGYSQHGSASGHFSSQGRHGSTSGQSSSSGQH------DSSSGQS 864

Query: 81   KSQQYDLNALHKATKSKQHLGGSQQLLNYKQEGRD---------HDKSKGHFHMIVIHHK 131
             S     +A H A+   +H  GS Q   + Q G           H    G       H  
Sbjct: 865  SSYGQHESASHHASGRGRHGSGSGQSPGHGQRGSGSGQSPSYGRHGSGSGRSSSSGRHGS 924

Query: 132  G-----GQAHHGTQNPSQDQGNSPSGKGLSSQCSNTEKRLWVHGLSKEQASASGAQKGRT 186
            G     G  H  +   S       SG G SS       R      S++  S+SG+     
Sbjct: 925  GSGQSSGFGHKSSSGQSSGYTQHGSGSGHSSSYEQHGSRSGQSSRSEQHGSSSGSSSSYG 984

Query: 187  QGGSQSSYVLQTEELVVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHPAHQDRL 246
            Q GS                      S Q+ GH Q        H S    S  P+   R 
Sbjct: 985  QHGS---------------------GSRQSLGHGQ--------HGSGSGQSPSPS---RG 1012

Query: 247  QHGPKDIFTTQDELLVYNKNQHQTKNLSQDQE-HGRKAHKISYPSSRTEERQLHHGEKSV 305
            +HG                   Q+ +    +   G  + +  Y S       L H E   
Sbjct: 1013 RHG---------------SGSGQSSSYGPYRSGSGWSSSRGPYESGSGHSSGLGHRESRS 1057

Query: 306  QKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSSTEERHLNCGEKGI 365
             +    G          HG S    + H Q   HG           ST  +  +CG+ G 
Sbjct: 1058 GQSSGYGQ---------HGSSSGHSSTHGQ---HG-----------STSGQSSSCGQHGA 1094

Query: 366  QKGVSK-----GSISIQTE---EQIHGKSQNQVRIPSQAQEYGHKENKISY-QSSSTEER 416
              G S      GS S Q+     Q  G  Q+    P   Q         SY +  S   R
Sbjct: 1095 SSGQSSSHGQHGSGSSQSSGYGRQGSGSGQS----PGHGQRGSGSRQSPSYGRHGSGSGR 1150

Query: 417  RLNSGEKDVQKGVSKGSISIQTEEKIHGKSQNQVTIPS-QDQEHGHKENKMSYQSSSTEE 475
              +SG+     G S G       E   G+S +     S      G+ ++      SS  E
Sbjct: 1151 SSSSGQHGSGLGESSG---FGHHESSSGQSSSYSQHGSGSGHSSGYGQHGSRSGQSSRGE 1207

Query: 476  RRLNYGGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQNAKGKSGQSADSKQ 535
            R  +  G S+      S          +G     +P+       G++  G    S+  + 
Sbjct: 1208 RHGSSSGSSSHYGQHGSGSRQSSGHGRQGSGSGHSPS------RGRHGSGLGHSSSHGQH 1261

Query: 536  DLLSHEQKGRYKQESSESHNIVITEHE 562
               S     R   ES   H+ V  +HE
Sbjct: 1262 GSGSGRSSSRGPYESRSGHSSVFGQHE 1288



 Score = 38.1 bits (87), Expect = 0.022
 Identities = 83/392 (21%), Positives = 126/392 (32%), Gaps = 70/392 (17%)

Query: 17   KQAAVMGQKGGSKGQLPS------------GSSQFPHGQ-------KGQHYFGQKDQQ-- 55
            +Q+   GQ G   GQ PS             SS  P+G        +G +  G       
Sbjct: 2401 RQSLGHGQHGSGSGQSPSPSRGRHGSGSGQSSSYSPYGSGSGWSSSRGPYESGSGHSSGL 2460

Query: 56   -HTKSKGSFSIQHTYHVDINDHDWTR-----KSQQYDLNALHKATKSK-----QHLGGSQ 104
             H +S+   S  +  H   + H  T       S Q      H A+  +     QH  GS 
Sbjct: 2461 GHRESRSGQSSGYGQHGSSSGHSSTHGQHGSTSGQSSSCGQHGASSGQSSSHGQHGSGSS 2520

Query: 105  QLLNYKQEGRDHDKSKGHFHMIVIHHKGGQAHHGTQNPSQDQGNSPSGKGLSSQCSNT-- 162
            Q   Y ++G    +S GH         G +     Q+PS  +  S SG+  SS    +  
Sbjct: 2521 QSSGYGRQGSGSGQSPGH---------GQRGSGSRQSPSYGRHGSGSGRSSSSGQHGSGL 2571

Query: 163  -EKRLWVHGLSKEQASASGAQKGRTQGGSQSSYVLQTEELVVNKQQRETKNSHQNKGHYQ 221
             E   + H  S    S+S +Q G   G S       +     ++ +R   +S  +  + Q
Sbjct: 2572 GESSGFGHHESSSGQSSSYSQHGSGSGHSSGYGQHGSRSGQSSRGERHGSSSGSSSHYGQ 2631

Query: 222  NVVDVREEHSSKLQTSLHPAHQDRLQHGPKDIFTTQDELLVYNKNQHQTKNLSQDQEHGR 281
            +    R+      Q S       R +HG                       L     HG+
Sbjct: 2632 HGSGSRQSSGHGRQGSGSGQSPSRGRHG---------------------SGLGHSSSHGQ 2670

Query: 282  KAHKISYPSSR-TEERQLHHGEKSVQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQEHG 340
                    SSR   E +L H     Q +   G  S  ++   HG          Q     
Sbjct: 2671 HGSGSGRSSSRGPYESRLGHSSVFGQHESGSGHSSAYSQ---HGSGSGHFCSQGQHGSTS 2727

Query: 341  HKENKISYQSSSTEERHLNCGEKGIQKGVSKG 372
             + +    + SST +   + G +G     S G
Sbjct: 2728 GQSSTFDQEGSSTGQSS-SYGHRGSGSSQSSG 2758


>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
          Length = 2454

 Score = 49.7 bits (117), Expect = 7e-06
 Identities = 117/571 (20%), Positives = 209/571 (36%), Gaps = 113/571 (19%)

Query: 81   KSQQYDLNALHKATKSKQHLGGSQQLLNYKQEGRDHDKSKGHFHMIVIHHKGGQAHHGTQ 140
            +S  YD + L K  KS   +G ++         +D D S+   H      K G  + G +
Sbjct: 775  ESSNYD-SELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHS-----KKGMDNQGHK 828

Query: 141  N-------PSQDQGNSPSGKGLSSQCSNTEKRLWVHGL-----SKEQASASGAQKGRTQG 188
            N        S D       +  SS     +K   +  L      K+QASAS     +  G
Sbjct: 829  NLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSG 888

Query: 189  GSQSSYVLQTEELVVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHPAHQDRLQ- 247
              QS   L+  ++   K++ +   +   K     + D+ E+   K Q+    +  D+ Q 
Sbjct: 889  KEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSD-ETSEDDKKQS 947

Query: 248  -------HGPKDI--------------------FTTQDELLVYNKNQHQTKNLSQDQEHG 280
                     P D                        ++E+  + K   Q KN + D E  
Sbjct: 948  KKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGE-- 1005

Query: 281  RKAHKISYPSSRTEERQLHHGEKSVQKDVSKGSISIQTEE-----------KIHGKS--Q 327
            +K+ KI   +S+ ++    + EKS  K  S  S   +  +           K+ GKS  +
Sbjct: 1006 KKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRK 1065

Query: 328  NQVTIHSQDQEHGHKENKISYQSSSTEERHL----NCGEKGIQKGVSKGSISIQTEEQIH 383
             Q    S  +++  KE+  +      +   L    N   K   K +  GS S   EE   
Sbjct: 1066 RQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEESSE 1125

Query: 384  GKSQNQVRIPSQAQEYGHKENKISYQSSSTEERRL-------NSGEKDVQKGVSKGSISI 436
               + + R  S+ +    KE K +   +ST+ ++        +  E D Q  + +GS   
Sbjct: 1126 DNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGS--- 1182

Query: 437  QTEEKIHGKSQNQV------------------TIP---SQDQEHGHKENKMSYQSSSTEE 475
              E+KI   ++N V                  ++P     D +    EN+++ +    EE
Sbjct: 1183 SDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIA-KKMLLEE 1241

Query: 476  RRLNYGGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQNAKGKSGQSADSKQ 535
             + N    S+ +D S        ++  EGK   +T   N++    + AK +    +DS  
Sbjct: 1242 IKANL---SSDEDGSSD------DEPEEGKK--RTGKQNEENPGDEEAKNQVNSESDSDS 1290

Query: 536  DLLSHEQKGRYKQESSESHNIVITEHEVAQD 566
            +     +K RY+      H + +++ E  ++
Sbjct: 1291 E---ESKKPRYRHRLLR-HKLTVSDGESGEE 1317



 Score = 39.7 bits (91), Expect = 0.008
 Identities = 84/420 (20%), Positives = 167/420 (39%), Gaps = 44/420 (10%)

Query: 159  CSNTEKRLWVHGLSKEQASASGAQKGRTQGGSQSSYVLQTEELVVNKQQRETKNSHQNKG 218
            C++++KRL    L + +  +S       Q GS SS   ++ E    K+QR +        
Sbjct: 1084 CNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSK------ 1137

Query: 219  HYQNVVDVREEHSSKLQTSLHPAHQDRLQHGPKDIFTTQDELLVYNKNQHQTKNLSQDQE 278
              +  V V+E+  + L+TS      D       DI   +D+      +Q+     S D++
Sbjct: 1138 --KKAVIVKEKKRNSLRTSTKRKQADITSSSSSDI---EDD------DQNSIGEGSSDEQ 1186

Query: 279  HGRKAHKISYPSSRTEERQLHHGEKSVQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQE 338
              +   +    SS T   Q   G++++ K V    +++  ++      +N++      +E
Sbjct: 1187 KIKPVTENLVLSSHTGFCQ-SSGDEALSKSVP---VTVDDDDD-DNDPENRIAKKMLLEE 1241

Query: 339  HGHKENKISYQSSSTEERHLNCGEKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQE 398
               K N  S +  S+++     G+K   K   +     + + Q++ +S +     S+   
Sbjct: 1242 I--KANLSSDEDGSSDDEPEE-GKKRTGKQNEENPGDEEAKNQVNSESDSDSE-ESKKPR 1297

Query: 399  YGHK--ENKISYQSS-STEERRLNSGEKDVQKGVSKGSISIQTEEK--IHGKSQNQVTIP 453
            Y H+   +K++     S EE++    E    KG ++  +S +  E         ++    
Sbjct: 1298 YRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSE 1357

Query: 454  SQDQEHGH---------KENKMSYQSSSTEERRLNYGGKSTQKDVSQSSISFQIEKLVEG 504
            S+D++            +EN+ SY+    + RR+     S+ ++ S S    + EK  E 
Sbjct: 1358 SEDEQRPRTRSAKKAELEENQRSYKQKK-KRRRIKVQEDSSSENKSNSE-EEEEEKEEEE 1415

Query: 505  KSQIQTPNPNQDQWSGQNAKGKSGQSADS--KQDLLSHEQKGRYKQESSESHNIVITEHE 562
            + + +     +D+     + GK  +      K D L  E +   K+E      I   E E
Sbjct: 1416 EEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEERRKRIAERERE 1475


>gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]
          Length = 2492

 Score = 49.7 bits (117), Expect = 7e-06
 Identities = 117/571 (20%), Positives = 209/571 (36%), Gaps = 113/571 (19%)

Query: 81   KSQQYDLNALHKATKSKQHLGGSQQLLNYKQEGRDHDKSKGHFHMIVIHHKGGQAHHGTQ 140
            +S  YD + L K  KS   +G ++         +D D S+   H      K G  + G +
Sbjct: 813  ESSNYD-SELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHS-----KKGMDNQGHK 866

Query: 141  N-------PSQDQGNSPSGKGLSSQCSNTEKRLWVHGL-----SKEQASASGAQKGRTQG 188
            N        S D       +  SS     +K   +  L      K+QASAS     +  G
Sbjct: 867  NLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSG 926

Query: 189  GSQSSYVLQTEELVVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHPAHQDRLQ- 247
              QS   L+  ++   K++ +   +   K     + D+ E+   K Q+    +  D+ Q 
Sbjct: 927  KEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSD-ETSEDDKKQS 985

Query: 248  -------HGPKDI--------------------FTTQDELLVYNKNQHQTKNLSQDQEHG 280
                     P D                        ++E+  + K   Q KN + D E  
Sbjct: 986  KKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGE-- 1043

Query: 281  RKAHKISYPSSRTEERQLHHGEKSVQKDVSKGSISIQTEE-----------KIHGKS--Q 327
            +K+ KI   +S+ ++    + EKS  K  S  S   +  +           K+ GKS  +
Sbjct: 1044 KKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRK 1103

Query: 328  NQVTIHSQDQEHGHKENKISYQSSSTEERHL----NCGEKGIQKGVSKGSISIQTEEQIH 383
             Q    S  +++  KE+  +      +   L    N   K   K +  GS S   EE   
Sbjct: 1104 RQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEESSE 1163

Query: 384  GKSQNQVRIPSQAQEYGHKENKISYQSSSTEERRL-------NSGEKDVQKGVSKGSISI 436
               + + R  S+ +    KE K +   +ST+ ++        +  E D Q  + +GS   
Sbjct: 1164 DNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGS--- 1220

Query: 437  QTEEKIHGKSQNQV------------------TIP---SQDQEHGHKENKMSYQSSSTEE 475
              E+KI   ++N V                  ++P     D +    EN+++ +    EE
Sbjct: 1221 SDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIA-KKMLLEE 1279

Query: 476  RRLNYGGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQNAKGKSGQSADSKQ 535
             + N    S+ +D S        ++  EGK   +T   N++    + AK +    +DS  
Sbjct: 1280 IKANL---SSDEDGSSD------DEPEEGKK--RTGKQNEENPGDEEAKNQVNSESDSDS 1328

Query: 536  DLLSHEQKGRYKQESSESHNIVITEHEVAQD 566
            +     +K RY+      H + +++ E  ++
Sbjct: 1329 E---ESKKPRYRHRLLR-HKLTVSDGESGEE 1355



 Score = 39.7 bits (91), Expect = 0.008
 Identities = 84/420 (20%), Positives = 167/420 (39%), Gaps = 44/420 (10%)

Query: 159  CSNTEKRLWVHGLSKEQASASGAQKGRTQGGSQSSYVLQTEELVVNKQQRETKNSHQNKG 218
            C++++KRL    L + +  +S       Q GS SS   ++ E    K+QR +        
Sbjct: 1122 CNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSK------ 1175

Query: 219  HYQNVVDVREEHSSKLQTSLHPAHQDRLQHGPKDIFTTQDELLVYNKNQHQTKNLSQDQE 278
              +  V V+E+  + L+TS      D       DI   +D+      +Q+     S D++
Sbjct: 1176 --KKAVIVKEKKRNSLRTSTKRKQADITSSSSSDI---EDD------DQNSIGEGSSDEQ 1224

Query: 279  HGRKAHKISYPSSRTEERQLHHGEKSVQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQE 338
              +   +    SS T   Q   G++++ K V    +++  ++      +N++      +E
Sbjct: 1225 KIKPVTENLVLSSHTGFCQ-SSGDEALSKSVP---VTVDDDDD-DNDPENRIAKKMLLEE 1279

Query: 339  HGHKENKISYQSSSTEERHLNCGEKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQE 398
               K N  S +  S+++     G+K   K   +     + + Q++ +S +     S+   
Sbjct: 1280 I--KANLSSDEDGSSDDEPEE-GKKRTGKQNEENPGDEEAKNQVNSESDSDSE-ESKKPR 1335

Query: 399  YGHK--ENKISYQSS-STEERRLNSGEKDVQKGVSKGSISIQTEEK--IHGKSQNQVTIP 453
            Y H+   +K++     S EE++    E    KG ++  +S +  E         ++    
Sbjct: 1336 YRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSE 1395

Query: 454  SQDQEHGH---------KENKMSYQSSSTEERRLNYGGKSTQKDVSQSSISFQIEKLVEG 504
            S+D++            +EN+ SY+    + RR+     S+ ++ S S    + EK  E 
Sbjct: 1396 SEDEQRPRTRSAKKAELEENQRSYKQKK-KRRRIKVQEDSSSENKSNSE-EEEEEKEEEE 1453

Query: 505  KSQIQTPNPNQDQWSGQNAKGKSGQSADS--KQDLLSHEQKGRYKQESSESHNIVITEHE 562
            + + +     +D+     + GK  +      K D L  E +   K+E      I   E E
Sbjct: 1454 EEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEERRKRIAERERE 1513


>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
          Length = 1429

 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 84/374 (22%), Positives = 135/374 (36%), Gaps = 79/374 (21%)

Query: 121  GHFHMIVIHHKGGQA----------HHGTQNPSQDQGNSPSGKGLSSQCSNTEKRLWVHG 170
            GH  +I +  K G +          H   Q P Q   +      + S  S +       G
Sbjct: 1089 GHSQIIKLLEKYGASSLNGCSPSPVHTMEQKPLQSLSSKVQSLTIKSNSSGST------G 1142

Query: 171  LSKEQASASGAQKGRTQGGSQSSYVLQTEELVVNKQQRETKNSHQNKGHYQNVVDVREEH 230
                Q S  G   G T   S  S   ++ +  V++Q+    N+            ++   
Sbjct: 1143 GGDMQPSLRGLPNGPTHAFSSPS---ESPDSTVDRQKSSLSNN-----------SLKSSK 1188

Query: 231  SSKLQTSLHPAHQDRLQHGPKDIFTTQDELLVYNKNQHQTKNLSQDQEHG----RKAHKI 286
            +S L+T+   A     Q  P D F             H      Q Q+H     R    I
Sbjct: 1189 NSSLRTTSSTA---TAQTVPIDSF-------------HNLSFTEQIQQHSLPRSRSRQSI 1232

Query: 287  SYPSSRTEERQLHHGEKSVQKDVSKGSISIQ-TEEKIHGKSQNQVTIHSQDQEHGHKENK 345
              PSS T+     H   S + + S+   S++ T+    GKS+N     S          K
Sbjct: 1233 VSPSSTTQSLGQSHNSPSSEFEWSQVKPSLKSTKASKGGKSENSAKSGSA--------GK 1284

Query: 346  ISYQSSSTEERHLNCGEKGI-QKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKEN 404
             + QS+S++ + L        ++G    S +    +Q+  +SQ ++ IPS  QE G  + 
Sbjct: 1285 KAKQSNSSQPKVLEYEMTQFDRRGPIAKSGTAAPPKQMPAESQCKIMIPSAQQEIGRSQQ 1344

Query: 405  KISYQSSSTEERRLNSGEKDVQKGVSKGSISIQTEEKIHGKSQN----QVTIPSQDQEHG 460
            +      S E+++ N                I T    H +S      +V++P   Q+ G
Sbjct: 1345 QFLIHQQSGEQKKRNG---------------IMTNPNYHLQSNQVFLGRVSVPRTMQDRG 1389

Query: 461  HKENKMSYQSSSTE 474
            H+E    Y SS TE
Sbjct: 1390 HQEVLEGYPSSETE 1403


>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
           sapiens]
          Length = 436

 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 48/263 (18%), Positives = 108/263 (41%), Gaps = 30/263 (11%)

Query: 170 GLSKEQASASGAQKGRT-----QGGSQSSYVLQTEELVVNKQQRETKNSHQNKGHYQNVV 224
           G  +EQ    G Q+G+      Q G Q    +Q +E  + +Q+ + +   +  G  +  V
Sbjct: 185 GQVREQEGQMGEQEGQMGEQEEQMGEQEEQ-MQKQEEQMGEQEEQMRKQEEQMGEQEEQV 243

Query: 225 DVREEHSSKLQTSLHPAHQDRLQHGPKDIFTTQDELLVYNKNQHQTKNLSQDQEHGRKAH 284
             +EE   K +  +    Q+      ++    Q+E ++  K Q + +  + +QE   +  
Sbjct: 244 QKQEEQVQKQEEQMRK--QEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQ 301

Query: 285 KISYPSSRTEERQLHHGEKSV-QKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKE 343
           +      R +E Q+   E+ + +++   G    Q  E+     + +  +  Q+++ G +E
Sbjct: 302 E---EQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQE 358

Query: 344 NKISYQSSSTEERHLNCGEKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKE 403
            ++  Q                ++ V K    ++ +E+   K + Q+R   Q ++ G ++
Sbjct: 359 EQMQKQ----------------EEQVRKQEEQMRKQEEQMRKQEEQMR--KQEEQMGEQK 400

Query: 404 NKISYQSSSTEERRLNSGEKDVQ 426
            ++  Q     E+    GE+  Q
Sbjct: 401 EQMGEQKEQMREQEEQMGEQKEQ 423


>gi|224548936 hypothetical protein LOC100170229 [Homo sapiens]
          Length = 715

 Score = 46.6 bits (109), Expect = 6e-05
 Identities = 85/472 (18%), Positives = 185/472 (39%), Gaps = 57/472 (12%)

Query: 142 PSQDQGNSPSGKGLSSQCSNTEKRLWVHGLSKEQASASGAQKGRTQGGSQSSYVLQTEEL 201
           PS+++ ++PS    SS+   +  ++ +   S+E++ +      R +  +Q+S   + +  
Sbjct: 226 PSKEKSDNPSPS--SSRKVKSYGQMIIP--SREKSYSPTEMSSRVKSYNQASTRSRPQSH 281

Query: 202 VVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHPAHQDRLQHGPKDIFTTQDELL 261
             ++  R +++  Q + H +    VR  HS K     H   + R + G         +  
Sbjct: 282 SQSRSPRRSRSGSQKRTHSR----VRS-HSWKRN---HSRARSRTRKGILSQMGRHSQSR 333

Query: 262 VYNKNQHQTKNLSQDQEHGR---------KAHKISYPSSRTEERQLHHGEKSVQKDVSKG 312
            ++K + Q  N S+    GR         K    S+  S ++ER  H G  S +K+  + 
Sbjct: 334 SHSKGKSQ--NQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKERD-HRGSSSPRKESGRS 390

Query: 313 SISIQTEEKIHGKSQN----------QVTIHSQDQEHGHKENKIS--------YQSSSTE 354
                 +++ H +S++          +    ++D+      NK          Y++    
Sbjct: 391 QSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRS 450

Query: 355 ERHLNCGEKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTE 414
                   +   +  S      ++  +   K ++  ++ S ++E  H+ ++   +     
Sbjct: 451 RSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCR 510

Query: 415 ERRLNSGEKDVQKGVSKGSISIQTEEKIHGKSQNQVTIPSQDQEHGHKENKMSYQSSSTE 474
           + R +S E+D ++  S      + + +   K +++    S  +E  H++++    S S E
Sbjct: 511 QSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQSR----SPSKE 566

Query: 475 ERRLNYGGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQNAKGK----SGQS 530
             R  +   S +++  QS  S +        S+ ++PN  Q  +S   A  K    S   
Sbjct: 567 RDRRRWRSPSKERERRQSRSSSE----ERDHSRSRSPN-KQSGYSRPRASSKEKAHSRSR 621

Query: 531 ADSKQDLLSHEQKGRYKQESSESHNIVITEHEVAQDDHLTQQYNEDRNPIST 582
             SK+   +H Q     +ES  S + V    +  +    T   +++R P  T
Sbjct: 622 TPSKEG--NHSQSRTSSKESDPSQSTVPRSPDWKRSPTRTSSLSQNRTPSKT 671


>gi|4504487 histidine rich calcium binding protein precursor [Homo
           sapiens]
          Length = 699

 Score = 46.6 bits (109), Expect = 6e-05
 Identities = 86/460 (18%), Positives = 162/460 (35%), Gaps = 83/460 (18%)

Query: 91  HKATKSKQHLGGSQQLLNYKQEGRDHDKSKGHFHMIVIHHKGGQAHHGTQNPSQDQGNSP 150
           H+A + + H  GS++         D D S GH H    H    Q H    +   D  +  
Sbjct: 211 HQAHRHRGH--GSEE---------DEDVSDGHHHHGPSHRH--QGHEEDDDDDDDDDDDD 257

Query: 151 SGKGLSSQCSNTEKRLWVHGLSKEQASASGAQKGRTQGGSQSSYVLQTEELVVNKQQRET 210
               +S +  +   R   HG+ +++  + G          +S      ++  V+ +    
Sbjct: 258 DDDDVSIEYRHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSHEEDDNDDDDVSTEYGHQ 317

Query: 211 KNSHQNKGHYQNVVDVREEHSSKLQTSLHPAHQDR-----------------LQHGPKDI 253
            + HQ+    + V  V  EH   +    H  H+D                  + HG  D 
Sbjct: 318 AHRHQDH-RKEEVEAVSGEHHHHVPDHRHQGHRDEEEDEDVSTERWHQGPQHVHHGLVDE 376

Query: 254 FTTQDELLV---YNKNQHQTKNLSQDQEHGRKAHKISYPSSRTEERQLHHGEKSVQKDVS 310
              ++E+ V   +    HQ +    D+E  +  +K   P         HH  +  +++  
Sbjct: 377 EEEEEEITVQFGHYVASHQPRGHKSDEEDFQDEYKTEVPH--------HHHHRVPREEDE 428

Query: 311 KGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSSTEERHLNCGEKGIQKGVS 370
           + S  +  +   H +S        QD+E GH +     + S  E  H   G   +     
Sbjct: 429 EVSAELGHQAPSHRQSH-------QDEETGHGQ-----RGSIKEMSHHPPGHTVV----- 471

Query: 371 KGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEERRLNSGEKDVQKGVS 430
                         K ++ +R     +E   +E+  S++    ++     GEK    G S
Sbjct: 472 --------------KDRSHLRKDDSEEEKEKEEDPGSHEE---DDESSEQGEKGTHHG-S 513

Query: 431 KGSISIQTEEKIHGKSQNQVTIPSQDQEHGHKENKMSYQSSSTEERRLNYGGK-STQKDV 489
           +     + EE+ HG S NQ     +++E   KE +   +     E R   G   S     
Sbjct: 514 RDQEDEEDEEEGHGLSLNQ-----EEEEEEDKEEEEEEEDEERREERAEVGAPLSPDHSE 568

Query: 490 SQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQNAKGKSGQ 529
            +      +E+     + I  P   +++  G +++ +SG+
Sbjct: 569 EEEEEEEGLEEDEPRFTIIPNPLDRREEAGGASSEEESGE 608



 Score = 39.3 bits (90), Expect = 0.010
 Identities = 57/262 (21%), Positives = 98/262 (37%), Gaps = 52/262 (19%)

Query: 197 QTEELVVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLH----------------- 239
           + EE  +  Q      SHQ +GH  +  D ++E+ +++    H                 
Sbjct: 377 EEEEEEITVQFGHYVASHQPRGHKSDEEDFQDEYKTEVPHHHHHRVPREEDEEVSAELGH 436

Query: 240 --PAHQDRLQ-----HGP----KDIFTTQDELLVYNKNQHQTKNLSQDQ---EHGRKAHK 285
             P+H+   Q     HG     K++        V     H  K+ S+++   E    +H+
Sbjct: 437 QAPSHRQSHQDEETGHGQRGSIKEMSHHPPGHTVVKDRSHLRKDDSEEEKEKEEDPGSHE 496

Query: 286 ISYPSSRTEERQLHHGEKSVQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENK 345
               SS   E+  HHG +  + +        + EE+ HG S N        QE   +E+K
Sbjct: 497 EDDESSEQGEKGTHHGSRDQEDE--------EDEEEGHGLSLN--------QEEEEEEDK 540

Query: 346 ISYQSSSTEERHLNCGEKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENK 405
              +    EER     E G          S + EE+  G  +++ R          +E  
Sbjct: 541 EEEEEEEDEERREERAEVGAPLSPDH---SEEEEEEEEGLEEDEPRFTIIPNPLDRREE- 596

Query: 406 ISYQSSSTEERRLNSGEKDVQK 427
            +  +SS EE   ++G +D Q+
Sbjct: 597 -AGGASSEEESGEDTGPQDAQE 617


>gi|4557509 cylicin 2 [Homo sapiens]
          Length = 348

 Score = 46.2 bits (108), Expect = 8e-05
 Identities = 58/256 (22%), Positives = 101/256 (39%), Gaps = 19/256 (7%)

Query: 274 SQDQEHGRKAH-KISYPSSRTEERQLHHGEKSVQK--DVSKGSISIQTEEKIHGKSQNQV 330
           S+  E G+K   K +   +   E +L  G+K  +K  D+ KG      EEK+  K  ++ 
Sbjct: 109 SKAAEIGKKGEDKTTQKDTTDSESELKQGKKDSKKGKDIEKGK-----EEKLDAKKDSKK 163

Query: 331 TIHSQDQEHGHKENKISYQSSSTEERHLNCGEKGIQKGVSKGSISIQTEEQIHGKSQNQV 390
               +D E G    K S   S  E+       K  +K  +KG  S    E   G ++   
Sbjct: 164 G--KKDAEKG----KDSATESEDEKGGAKKDNKKDKKDSNKGKDSATESEGEKGGTEKDS 217

Query: 391 RIPSQAQEYGHKENKISYQSSSTEERRLNSGEKDVQKGVSKGSISIQTEEKIHGKSQNQV 450
           +   +  + G K++ I  Q+   +E++   G+KD  KG          +E   GK   + 
Sbjct: 218 KKGKKDSKKG-KDSAIELQAVKADEKKDEDGKKDANKGDESKDAKKDAKEIKKGKKDKKK 276

Query: 451 TIPSQDQEHGHKENKMSYQSSSTEERRLNYGGKSTQKDVSQSSISFQIEKLVEGKSQIQT 510
             PS        + K   +  +T++ +     K T+K+ + S    +     + K   + 
Sbjct: 277 --PSSTDSDSKDDVKKESKKDATKDAK-KVAKKDTEKESADSKKDAKKNAKKDAKKDAK- 332

Query: 511 PNPNQDQWSGQNAKGK 526
            N  +D+      KGK
Sbjct: 333 KNAKKDEKKDAKKKGK 348


>gi|171916097 repetin [Homo sapiens]
          Length = 784

 Score = 46.2 bits (108), Expect = 8e-05
 Identities = 99/538 (18%), Positives = 184/538 (34%), Gaps = 71/538 (13%)

Query: 40  PHGQKGQHYFGQ-----KDQQHTKSKGSFSIQHTYHVDINDHD-WTRKSQQYDLNALHKA 93
           P  Q G  + GQ     +D  H +S+      H    +  D D    +S++ D +     
Sbjct: 137 PERQDGDSHHGQPERQDRDSHHGQSEKQDRDSHHSQPERQDRDSHHNQSERQDKDFSFDQ 196

Query: 94  TKSKQHLGGSQQLLNYKQEGRDHDKSKGHFHM-------IVIHHKGGQAHHGTQNPSQDQ 146
           ++ +     S + +++K       K +GH          I   H G    H  Q+ +  Q
Sbjct: 197 SERQSQDSSSGKKVSHKSTS-GQAKWQGHIFALNRCEKPIQDSHYGQSERHTQQSETLGQ 255

Query: 147 G---NSPSGKGLSSQCSNTEKRLWVHGLSKEQASASGAQKGRTQGGSQSSYVLQTEELVV 203
               N  + +   S C  +E+     G  +       +  G+T    QS +  QT+    
Sbjct: 256 ASHFNQTNQQKSGSYCGQSERLGQELGCGQTDRQGQSSHYGQTDRQDQSYHYGQTDRQGQ 315

Query: 204 NKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHPAHQDRLQHGPKDIFTTQDELLVY 263
           +    +T    Q+  + Q     +  H  ++       H D+                  
Sbjct: 316 SSHYSQTDRQGQSSHYSQPDRQGQSSHYGQMDRKGQCYHYDQ------------------ 357

Query: 264 NKNQHQTKNLSQDQEHGRKAHKISYPSSRTEERQLHHGEKSVQKDVSKGSISIQTEEKIH 323
              Q Q  + SQ    G+ +H   Y    T+++  H+G+   Q   S      QTE +  
Sbjct: 358 TNRQGQGSHYSQPNRQGQSSH---YGQPDTQDQSSHYGQTDRQDQSSHYG---QTERQGQ 411

Query: 324 GKSQNQVTIHSQDQEHGHKENK---ISYQSSSTEERHLNCGEKGIQKGVS-------KGS 373
               +Q+    Q   +G  + +     Y     + ++ + G+   Q   S       +G 
Sbjct: 412 SSHYSQMDRQGQGSHYGQTDRQGQSSHYGQPDRQGQNSHYGQTDRQGQSSHYGQTDRQGQ 471

Query: 374 ISIQTEEQIHGKSQNQVRIPSQAQEYGHKE-----NKISYQSSSTEERRLNSGEKDVQKG 428
            S  ++    G+S +  +I  Q Q Y + +         Y  +  + +  + G+ D Q  
Sbjct: 472 SSHYSQPDKQGQSSHYGKIDRQDQSYHYGQPDGQGQSSHYGQTDRQGQSFHYGQPDRQGQ 531

Query: 429 VS-------KGSISIQTEEKIHGKSQNQVTIPSQDQEHGHKENKMSYQSS---STEERRL 478
            S       +G  S   +    G+S +      Q Q + + +     QSS    ++   +
Sbjct: 532 SSHYSQMDRQGQSSHYGQTDRQGQSSHYGQTDRQGQSYHYGQTDRQGQSSHYIQSQTGEI 591

Query: 479 NYGGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQNAKGKSGQSADSKQD 536
               K  Q        S+  +    G+   QTP        G   +G+  QS DS+Q+
Sbjct: 592 QGQNKYFQGTEGTRKASYVEQSGRSGRLSQQTPGQ-----EGYQNQGQGFQSRDSQQN 644



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 78/393 (19%), Positives = 143/393 (36%), Gaps = 27/393 (6%)

Query: 172 SKEQASASGAQKGRTQGGSQSSYVLQTEELVVNKQQRETKNSHQNKGHYQNVVDVREEHS 231
           S+++    GAQ  +  G +   +  + EE   N    + +    +  H Q     R+ H 
Sbjct: 99  SQQERGQEGAQDCKFPGNTGRQHRQRHEEERQNSHHSQPERQDGDSHHGQPERQDRDSHH 158

Query: 232 SKLQTSLHPAHQDRLQHGPKDIFTTQDELLVYNKNQHQTKNLSQDQEHGRK-AHKISYPS 290
            + +     +H  + +   +D    Q E    + +  Q++  SQD   G+K +HK +   
Sbjct: 159 GQSEKQDRDSHHSQPERQDRDSHHNQSERQDKDFSFDQSERQSQDSSSGKKVSHKSTSGQ 218

Query: 291 SRTEER--QLHHGEKSVQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISY 348
           ++ +     L+  EK +Q D   G     T++     S+        +Q +  K      
Sbjct: 219 AKWQGHIFALNRCEKPIQ-DSHYGQSERHTQQ-----SETLGQASHFNQTNQQKSGSYCG 272

Query: 349 QSSSTEERHLNCGEKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISY 408
           QS    +  L CG+   Q    + S   QT+ Q       Q     Q+  Y   + +   
Sbjct: 273 QSERLGQ-ELGCGQTDRQ---GQSSHYGQTDRQDQSYHYGQTDRQGQSSHYSQTDRQGQS 328

Query: 409 QSSSTEERRLNSGEKDVQKGVSKGSISIQTEEKIHGKSQNQVTIPSQDQEHGH---KENK 465
              S  +R+  S          +     QT  +  G   +Q     Q   +G    ++  
Sbjct: 329 SHYSQPDRQGQSSHYGQMDRKGQCYHYDQTNRQGQGSHYSQPNRQGQSSHYGQPDTQDQS 388

Query: 466 MSYQSSSTEERRLNYGGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQNAKG 525
             Y  +  +++  +YG    Q    QSS   Q+++  +G    QT    Q    GQ    
Sbjct: 389 SHYGQTDRQDQSSHYGQTERQ---GQSSHYSQMDRQGQGSHYGQTDRQGQSSHYGQ--PD 443

Query: 526 KSGQSA----DSKQDLLSHEQKGRYKQESSESH 554
           + GQ++      +Q   SH   G+  ++   SH
Sbjct: 444 RQGQNSHYGQTDRQGQSSH--YGQTDRQGQSSH 474


>gi|55749769 CWC22 spliceosome-associated protein homolog [Homo
           sapiens]
          Length = 908

 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 42/239 (17%), Positives = 90/239 (37%), Gaps = 29/239 (12%)

Query: 308 DVSKGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSSTEERHLNCGEKGIQK 367
           DV +   S  +       S++  +    D      E+      SS+   H +     ++K
Sbjct: 660 DVEQNKSSPSSSSSASSSSESDSSDSDSDSSDSSSESSSEESDSSSISSHSSASANDVRK 719

Query: 368 GVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEERRLNSGEKDVQK 427
                + S + ++ I  +  N  +   + QE+GH+E +   +  S + R  NS   + + 
Sbjct: 720 KGHGKTRSKEVDKLIRNQQTNDRKQKERRQEHGHQETRTERERRSEKHRDQNSSGSNWRD 779

Query: 428 GVSK--------------GSISIQTEEKIHGKSQNQVTIP-----------SQDQEHGHK 462
            ++K                ++   ++++H   +N+   P           S++++H H+
Sbjct: 780 PITKYTSDKDVPSERNNYSRVANDRDQEMHIDLENKHGDPKKKRGERRNSFSENEKHTHR 839

Query: 463 ----ENKMSYQSSSTEERRLNYGGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQ 517
               EN      S ++E    + G  + +D  Q+    + EK      Q +    NQD+
Sbjct: 840 IKDSENFRRKDRSKSKEMNRKHSGSRSDEDRYQNGAERRWEKSSRYSEQSRESKKNQDR 898



 Score = 37.0 bits (84), Expect = 0.050
 Identities = 26/151 (17%), Positives = 61/151 (40%)

Query: 403 ENKISYQSSSTEERRLNSGEKDVQKGVSKGSISIQTEEKIHGKSQNQVTIPSQDQEHGHK 462
           E+      SS+     ++   DV+K     + S + ++ I  +  N      + QEHGH+
Sbjct: 695 ESSSEESDSSSISSHSSASANDVRKKGHGKTRSKEVDKLIRNQQTNDRKQKERRQEHGHQ 754

Query: 463 ENKMSYQSSSTEERRLNYGGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQN 522
           E +   +  S + R  N  G + +  +++ +    +       S++      +     +N
Sbjct: 755 ETRTERERRSEKHRDQNSSGSNWRDPITKYTSDKDVPSERNNYSRVANDRDQEMHIDLEN 814

Query: 523 AKGKSGQSADSKQDLLSHEQKGRYKQESSES 553
             G   +    +++  S  +K  ++ + SE+
Sbjct: 815 KHGDPKKKRGERRNSFSENEKHTHRIKDSEN 845


>gi|87299628 biorientation of chromosomes in cell division 1-like
            [Homo sapiens]
          Length = 3051

 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 73/382 (19%), Positives = 149/382 (39%), Gaps = 42/382 (10%)

Query: 205  KQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHPAHQDRLQHGPKDIFTTQDELLVYN 264
            +++ +T++  +     +   +  ++  S L+   H    D      K +   + E+    
Sbjct: 668  QEETDTRDVKRQVERSEICTEEPQKQKSTLKNEKHLKKDDSETPHLKSLL--KKEVKSSK 725

Query: 265  KNQHQTKNLSQDQEHGRKAHKISYPSSRTEERQLHHGEKSV--------QKDVSKGSISI 316
            +   + K  S+D+   +  +K        +E +LH  EK +        Q   +K S   
Sbjct: 726  EKPEREKTPSEDKLSVKHKYKGDCMHKTGDETELHSSEKGLKVEENIQKQSQQTKLSSDD 785

Query: 317  QTEEKIHGKSQNQVTIHSQD----------------QEHGHKENKISYQSSSTEERHLNC 360
            +TE K   +++ ++++  +D                +E+  KE ++S + +  E +    
Sbjct: 786  KTERKSKHRNERKLSVLGKDGKPVSEYIIKTDENVRKENNKKERRLSAEKTKAEHKSRRS 845

Query: 361  GEKGIQK---GVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEERR 417
             +  IQK   G  +  I++Q   + +  S+++  + S   +   K  ++ ++    E+RR
Sbjct: 846  SDSKIQKDSLGSKQHGITLQRRSESY--SEDKCDMDSTNMDSNLKPEEVVHK----EKRR 899

Query: 418  LNS--GEKDVQKGVSK--GSISIQTEEKIHGKSQNQVTIPSQDQEHGHKENKMSYQSSST 473
              S   EK V K  SK  G      E ++   +  Q T P  D+E   +EN    Q  S 
Sbjct: 900  TKSLLEEKLVLKSKSKTQGKQVKVVETELQEGATKQATTPKPDKEKNTEENDSEKQRKSK 959

Query: 474  EERR--LNYGGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQNAKGKSGQSA 531
             E +     G +   +  S S+ S Q +     K  +       D+    + + +   S 
Sbjct: 960  VEDKPFEETGVEPVLETASSSAHSTQKDSSHRAKLPLAKEKYKSDK-DSTSTRLERKLSD 1018

Query: 532  DSKQDLLSHEQKGRYKQESSES 553
              K   L H  K   K++ ++S
Sbjct: 1019 GHKSRSLKHSSKDIKKKDENKS 1040



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 77/429 (17%), Positives = 162/429 (37%), Gaps = 52/429 (12%)

Query: 192 SSYVLQTEELVVNKQQRETKN--SHQNKGHYQNVVDVREEHSSKLQT-SLHPAHQDRLQH 248
           SS+   TEE VV     E     S   + + QN    +   SS+ +T S+  A+  +   
Sbjct: 417 SSFEEDTEEEVVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGKTKSVRHAYVHKPYL 476

Query: 249 GPKDIFTTQDELLVYNKNQHQTKNLSQ------------DQEHGRKAHKISYPSSRTEER 296
             K    + DEL V  + Q   K   +            +++  +KA K     ++ + R
Sbjct: 477 YSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKAEKTKSSKTKGQGR 536

Query: 297 QLHHGEKSVQKDVSKGSISIQT---EEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSST 353
                E+S  K +   +  I+    E K+  K         +D  +  + +K   Q    
Sbjct: 537 SSVDLEESSTKSLEPKAARIKEVLKERKVLEKKVALSKKRKKDSRNVEENSKKKQQYEED 596

Query: 354 EERHLNCGEKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGH--KENKISYQSS 411
            +  L   E   ++ +S    S +  + +H KS+   +   +  E  H   ENK   +  
Sbjct: 597 SKETLKTSEHCEKEKIS----SSKELKHVHAKSEPS-KPARRLSESLHVVDENKNESKLE 651

Query: 412 STEERRLNS-----------GEKDVQKGVSKGSISIQTEEKIHGKSQNQVTIPSQDQEHG 460
              +RR ++             +DV++ V +  I  +  +K     +N+  +   D E  
Sbjct: 652 REHKRRTSTPVIMEGVQEETDTRDVKRQVERSEICTEEPQKQKSTLKNEKHLKKDDSETP 711

Query: 461 HKENKMSYQSSSTEERRLNYGGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSG 520
           H ++ +  +  S++E+         +++ + S     ++   +G    +T +  +   S 
Sbjct: 712 HLKSLLKKEVKSSKEK--------PEREKTPSEDKLSVKHKYKGDCMHKTGDETELHSSE 763

Query: 521 QNAKGKSGQSADSKQDLLSHEQKGRYKQESSESHNI--------VITEHEVAQDDHLTQQ 572
           +  K +      S+Q  LS + K   K +      +         ++E+ +  D+++ ++
Sbjct: 764 KGLKVEENIQKQSQQTKLSSDDKTERKSKHRNERKLSVLGKDGKPVSEYIIKTDENVRKE 823

Query: 573 YNEDRNPIS 581
            N+    +S
Sbjct: 824 NNKKERRLS 832



 Score = 38.5 bits (88), Expect = 0.017
 Identities = 53/279 (18%), Positives = 110/279 (39%), Gaps = 29/279 (10%)

Query: 277  QEHGRKAHKISYPSSRTEERQLHHGEKSVQKDVSKGS----ISIQTEEKIHGKSQNQVTI 332
            +E+ +K  ++S   ++ E +     +  +QKD S GS    I++Q   + + + +  +  
Sbjct: 822  KENNKKERRLSAEKTKAEHKSRRSSDSKIQKD-SLGSKQHGITLQRRSESYSEDKCDMDS 880

Query: 333  HSQD-----QEHGHKENK----------ISYQSSSTEERHLNCGEKGIQKGVSKGSISIQ 377
             + D     +E  HKE +          +    S T+ + +   E  +Q+G +K + + +
Sbjct: 881  TNMDSNLKPEEVVHKEKRRTKSLLEEKLVLKSKSKTQGKQVKVVETELQEGATKQATTPK 940

Query: 378  TEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEE--RRLNSGEKDVQKGVSKGSIS 435
             +     K +N     S+ Q     E+K  ++ +  E      +S     QK  S  +  
Sbjct: 941  PD-----KEKNTEENDSEKQRKSKVEDK-PFEETGVEPVLETASSSAHSTQKDSSHRAKL 994

Query: 436  IQTEEKIHGKSQNQVTIPSQDQEHGHKENKMSYQSSSTEERRLNYGGKSTQKDVSQSSIS 495
               +EK      +  T   +    GHK   + + S   +++  N       K+V  S   
Sbjct: 995  PLAKEKYKSDKDSTSTRLERKLSDGHKSRSLKHSSKDIKKKDENKSDDKDGKEVDSSHEK 1054

Query: 496  FQ-IEKLVEGKSQIQTPNPNQDQWSGQNAKGKSGQSADS 533
             +    L+E K   +     +   S + AKG+   +A++
Sbjct: 1055 ARGNSSLMEKKLSRRLCENRRGSLSQEMAKGEEKLAANT 1093


>gi|36031016 CTCL tumor antigen L14-2 [Homo sapiens]
          Length = 898

 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 74/393 (18%), Positives = 158/393 (40%), Gaps = 33/393 (8%)

Query: 215 QNKGHYQNVVDVREEHSS-----KLQTSLHPAH-------QDRLQHGPKDIFTTQDELLV 262
           +NK H +  VD+  E  +     K +T     H       + R++   K++  ++D+L+ 
Sbjct: 215 ENKKHQELFVDICSEKDNLREELKKRTETEKQHMNTIKQLESRIEELNKEVKASRDQLIA 274

Query: 263 Y-----NKNQHQTKNLSQDQEHGRKAHKISYPSSRTEERQLHHGEKS---VQKDVSKGSI 314
                 N  Q   K ++Q  E   K  + +         +   GEK    ++K+      
Sbjct: 275 QDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRKEKETLEK 334

Query: 315 SIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSSTEERHLNCGEKGIQKGVSK--- 371
            ++   K   K+ N++   SQ++   H+  +     ++   R ++  ++ I   V K   
Sbjct: 335 KLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINSHVIKVKW 394

Query: 372 GSISIQTEEQIHGKSQNQVRIPS----QAQEYGHKENKISYQSSST--EERRLNSGEKDV 425
               ++ E   H +++++++  +    QA+E   +  K       T  E   + S E D 
Sbjct: 395 AQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNELDA 454

Query: 426 QKGVSKGSISIQTEEKIHGKSQNQVTIPS-QDQEHGHKENKMSYQSSSTEERRLNYGGKS 484
           +  V+KG +  Q +EK      +   I   +D +   KE     ++  T+ + L      
Sbjct: 455 KLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTLRTKVKCLEDERLR 514

Query: 485 TQKDVS--QSSISFQIEKLVEGKSQIQTPNPNQDQWS-GQNAKGKSGQSADSKQDLLSHE 541
           T+ ++S  +  I+ Q  ++     +++T +  Q+Q   G+       +  +S   L++  
Sbjct: 515 TEDELSKYKEIINRQKAEIQNLLDKVKTADQLQEQLQRGKQEIENLKEEVESLNSLINDL 574

Query: 542 QKGRYKQESSESHNIVITEHEVAQDDHLTQQYN 574
           QK        ES  ++ TE   +++  L  + N
Sbjct: 575 QKDIEGSRKRESELLLFTERLTSKNAQLQSESN 607


>gi|153251865 hypothetical protein LOC84226 [Homo sapiens]
          Length = 1984

 Score = 43.5 bits (101), Expect = 5e-04
 Identities = 87/424 (20%), Positives = 154/424 (36%), Gaps = 57/424 (13%)

Query: 151  SGKGLSSQCSNTEKRLWVHGLSKEQASASGAQKGRTQGGSQSSYVLQTEELVVNKQQRET 210
            S  G++ Q ++  + L    + K+ +S S     R +  SQ S  L T    V  + R  
Sbjct: 1460 SQSGIAFQTASVGQPL--RTVQKDSSSRSKKNFYRNETSSQESKNLSTPGTRVQARGRIL 1517

Query: 211  KNSHQNKGHYQNVVD--VREEHSSKLQTSLHPA-HQDRLQHGPKDIFTTQDELLVYNKNQ 267
              S   +  ++++ D    +EH+       HP+ +++R   GP +          +    
Sbjct: 1518 PGSPVKRTWHRHLKDKLTHKEHN-------HPSFYRERTPRGPSERTRHNPSWRNHRSPS 1570

Query: 268  HQTKNLSQDQEH-----------GRKAHKISYPSSRTEERQLHH---GEKSVQKDVSKGS 313
             +++  S ++ H            RK H      S     Q +H    E+S    +S+  
Sbjct: 1571 ERSQRSSLERRHHSPSQRSHCSPSRKNHSSPSERSWRSPSQRNHCSPPERSCHS-LSERG 1629

Query: 314  ISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSSTEERHLNCGEKGIQKGVSKGS 373
            +   ++    G SQ +   H    E  H+        SS+E RH +  ++   +G S+ S
Sbjct: 1630 LHSPSQRSHRGPSQRR---HHSPSERSHRSPSERSHRSSSERRHRSPSQRS-HRGPSERS 1685

Query: 374  ISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEERRLNSGEKDVQKGVSKGS 433
                +E +    SQ   R PS+ +   H  +K S++S +    R  S             
Sbjct: 1686 HCSPSERRHRSPSQRSHRGPSERRH--HSPSKRSHRSPARRSHRSPS------------- 1730

Query: 434  ISIQTEEKIHGKSQNQVTIPSQDQEHGHKENKMSYQSS----STEERRLNYGGKSTQKDV 489
                 E   H  S+     PS+ + H   E      S     S  ERR     +      
Sbjct: 1731 -----ERSHHSPSERSHHSPSERRHHSPSERSHCSPSERSHCSPSERRHRSPSERRHHSP 1785

Query: 490  SQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQNAKGKSGQSADSKQDLLSHEQKGRYKQE 549
            S+ S     E+     S+ +  +P +   S  +   +S +S   ++   S E+  R   E
Sbjct: 1786 SEKSHHSPSERSHHSPSERRRHSPLER--SRHSLLERSHRSPSERRSHRSFERSHRRISE 1843

Query: 550  SSES 553
             S S
Sbjct: 1844 RSHS 1847



 Score = 40.4 bits (93), Expect = 0.005
 Identities = 51/244 (20%), Positives = 86/244 (35%), Gaps = 33/244 (13%)

Query: 129  HHKGGQAHHGTQNPSQDQGNSPSGKGLSS-----QCSNTEKRLWVHGLSKE------QAS 177
            HH   Q  H +  PS+   +SPS +   S      CS  E+    H LS+       Q S
Sbjct: 1582 HHSPSQRSHCS--PSRKNHSSPSERSWRSPSQRNHCSPPERSC--HSLSERGLHSPSQRS 1637

Query: 178  ASGAQKGRTQGGSQSSYVLQTEELVVNKQQRE----TKNSHQNKGHYQNVVDVREEHSSK 233
              G  + R    S+ S+   +E    +  +R     ++ SH+      +       H S 
Sbjct: 1638 HRGPSQRRHHSPSERSHRSPSERSHRSSSERRHRSPSQRSHRGPSERSHCSPSERRHRSP 1697

Query: 234  LQTSLHPAHQDRLQHGPKDIFTTQDELLVYNKNQHQTKNLSQDQEHGRKAHKISYPSSRT 293
             Q S H    +R  H P             +K  H++      +    ++H      S  
Sbjct: 1698 SQRS-HRGPSERRHHSP-------------SKRSHRSPARRSHRSPSERSHHSPSERSHH 1743

Query: 294  EERQLHHGEKSVQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSST 353
               +  H   S +   S    S  +  +   +S ++   HS  ++  H  ++ S+ S S 
Sbjct: 1744 SPSERRHHSPSERSHCSPSERSHCSPSERRHRSPSERRHHSPSEKSHHSPSERSHHSPSE 1803

Query: 354  EERH 357
              RH
Sbjct: 1804 RRRH 1807


>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
          Length = 1301

 Score = 42.7 bits (99), Expect = 0.001
 Identities = 93/485 (19%), Positives = 179/485 (36%), Gaps = 81/485 (16%)

Query: 126 IVIHHKGGQAHHGTQNPSQDQGNSPS-----GKGLSSQCSNTEKRLWVHGLSKEQASAS- 179
           +++H         TQ+  + +GN        GK  S+  +   +   + G + +   A  
Sbjct: 59  VLVHEGDRGRQENTQDGHKGEGNGSKWAEVGGKSFSTYSTLANEEGNIEGWNGDTGKAET 118

Query: 180 -------GAQKGRTQGGSQSSYVLQTEELVVNKQQRE--TKNSHQN-----KGHYQNVVD 225
                  G ++  T  G Q    +       N+      T  + QN      GH ++V  
Sbjct: 119 YGHDGIHGKEENITANGIQGQVSIIDNAGATNRSNTNGNTDKNTQNGDVGDAGHNEDVAV 178

Query: 226 VREEHSSKLQTSLHPAHQDRLQHGPKDIFTTQDELLVYN-KNQHQTKNLSQDQEHGRKAH 284
           V+E+                   G  +    +DE++  + +N+  T  ++      R   
Sbjct: 179 VQEDGPQVA--------------GSNNSTDNEDEIIENSCRNEGNTSEITPQINSKRNGT 224

Query: 285 KISYPSSRT-EERQLHHGEKS-----VQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQE 338
           K +  +  T E+  L + + S       +D  +GS   + EE  +GK  +  +   + Q+
Sbjct: 225 KEAEVTPGTGEDAGLDNSDGSPSGNGADEDEDEGSGDDEDEEAGNGKDSSNNSKGQEGQD 284

Query: 339 HGHKENKISY--QSSSTEERHLNCGEKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQA 396
           HG +++  S   Q+S ++E +   G++     V     S   E        N  +     
Sbjct: 285 HGKEDDHDSSIGQNSDSKEYYDPEGKEDPHNEVDGDKTSKSEENSAGIPEDNGSQRIEDT 344

Query: 397 QEYGHK-----ENKISYQSSS----------TEERRLNSGEKDVQKGVSKGSISIQTEEK 441
           Q+  H+     EN+I+ +S +           E +  +SG +++ K V KG+   + ++ 
Sbjct: 345 QKLNHRESKRVENRITKESETHAVGKSQDKGIEIKGPSSGNRNITKEVGKGNEG-KEDKG 403

Query: 442 IHG--------KSQNQVTI---PSQDQEHGHKENKMSYQSSSTEE--RRLNYGGKSTQKD 488
            HG        K+Q +V     P Q  E G+K    +  S S  +     ++  KS Q D
Sbjct: 404 QHGMILGKGNVKTQGEVVNIEGPGQKSEPGNKVGHSNTGSDSNSDGYDSYDFDDKSMQGD 463

Query: 489 VSQSSISFQIEKLVEGKSQIQT---------PNPNQDQWSGQNAKGKSGQSADSKQDLLS 539
              SS           +S   +          + ++D  +G ++KG     +DS  D  +
Sbjct: 464 DPNSSDESNGNDDANSESDNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTNN 523

Query: 540 HEQKG 544
            +  G
Sbjct: 524 SDSNG 528


>gi|238624188 diffuse panbronchiolitis critical region 1 protein [Homo
            sapiens]
          Length = 1393

 Score = 42.4 bits (98), Expect = 0.001
 Identities = 55/312 (17%), Positives = 126/312 (40%), Gaps = 38/312 (12%)

Query: 256  TQDELLVYNKNQHQTKNLSQDQEHGRKAHKISYPSSRTEERQLHHGEKS-VQKDVSKGSI 314
            T+ E +    N+  T + ++  E+G +    +  ++ +      HGE++ +  +++  S 
Sbjct: 880  TEHEEMTPLANEKTTLSPAEPTENGERTPFTNEKTTPSSAEPTEHGERTPLANEITTPSR 939

Query: 315  SIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSSTEERHLNCGEKGIQKGVSKGSI 374
            +  TE      ++      ++  EHG  E  ++  ++ +       GE+      ++ + 
Sbjct: 940  AEPTEHGERIANEKATPSPAKPTEHG--ETTVNEDTTPSSAEPTENGER--TPLANENTT 995

Query: 375  SIQTEEQIHG-KSQNQVRIPSQAQEYGHKENKISYQSSSTEERRLNSGEKDVQKGVSKGS 433
            +  TE   HG ++ N+   PS A+   H E     ++ S  E+ + S  K  +       
Sbjct: 996  TSPTESTEHGERTANEKTTPSPAEPTEHGE-----RTPSANEKTIPSPAKPTEH------ 1044

Query: 434  ISIQTEEKIHGKSQNQVTIPSQDQEHGHKENKMSYQSSSTEERRLNYGGKSTQKDVSQSS 493
                 EE     ++N    P +  EHG K    + + + + E    +G K+T    +   
Sbjct: 1045 -----EEMTPSANENTTPSPVKPTEHGEKTTLANEKITLSPEGPTEHGAKTTS---ANEK 1096

Query: 494  ISFQIEKLVEGKSQIQTPNPNQDQWSGQNAKGKSGQSA-------------DSKQDLLSH 540
            I+  + K  E   +  +PN      + ++ + +   ++              +K+  L+H
Sbjct: 1097 ITPSLAKPTEHGERTTSPNDKITSSAAESTEHRDRATSANVITPAPAEPIKHAKRTTLAH 1156

Query: 541  EQKGRYKQESSE 552
            E+  +  ++S+E
Sbjct: 1157 EKMTQVTEKSTE 1168



 Score = 31.6 bits (70), Expect = 2.1
 Identities = 51/325 (15%), Positives = 124/325 (38%), Gaps = 33/325 (10%)

Query: 266 NQHQTKNLSQDQEHGRKAHKISYPSSRTEERQLHHGEKSVQKDVSKGSISIQTEEKIHGK 325
           N++ T + ++  EHG +    +  ++ +      HGE++           +  E      
Sbjct: 389 NENTTPSPAEPTEHGERTPFANDKTTSSSAESTEHGERT----------PLANENTTPSP 438

Query: 326 SQNQVTIHSQDQEHGHKENKISYQSSSTEERHLNCGEKGIQKGVSKGSISIQTEEQIHGK 385
           ++      ++++E    EN     +  TE R     EK     V        TE +    
Sbjct: 439 AE-----PTENRERTANENTTPSPAGPTENRETTANEKTTLSPVE------PTENRETTA 487

Query: 386 SQNQVRIPSQAQEYGHKENKISYQSSSTEERRLNSGEK-DVQKGVSKGSISIQTEEKIHG 444
           ++     P++  E G +    + +++S+       GE+  +    +  S +  TE +   
Sbjct: 488 NEKTTPSPAEPTENGQRTPFANEKTTSSSAEPTEHGERTPLANENTTPSPAEPTENRERT 547

Query: 445 KSQNQVTIPSQDQEHGHKENKMSYQSSSTEERRLNYGGK---STQKDVSQSSISFQIEKL 501
            ++     P++  E+G +    + +++ +       G +   + +K  S S+   + E+ 
Sbjct: 548 ANEKTTPSPAEPTENGDRTPLANEKTTPSLAEPTENGQRTPFANEKTTSSSAEPTEHEER 607

Query: 502 VEGKSQIQTPNP-----NQDQWSGQNAKGKSGQSADSKQDLLSHEQKGRYKQESSESHNI 556
               ++  TP+P     N+++ + +N    S       +++ ++E+   +  E +E+   
Sbjct: 608 TPLANENTTPSPAEPTENRERTANENTT-PSPAGPTENREMTANEKTTLFPAEPTENRER 666

Query: 557 VITEHEVAQDDHLTQQYNEDRNPIS 581
              E   +     T+  N  R P +
Sbjct: 667 TANEKTTSSPAEPTE--NGQRTPFA 689


>gi|153792012 DNA polymerase zeta [Homo sapiens]
          Length = 3130

 Score = 42.4 bits (98), Expect = 0.001
 Identities = 87/405 (21%), Positives = 152/405 (37%), Gaps = 49/405 (12%)

Query: 141  NPSQDQGNSPSGKGLSSQCSNTEKRLWVHGLSKEQASASGAQKGRTQGGSQSSYVLQTEE 200
            N + ++   P+   ++S  S  ++  W           S  +  R +  S S  + QT+ 
Sbjct: 1446 NTASEESQMPNNCFVTSLRSPIKQIAWEQKQRGFILDMSNFKPERVKPRSLSEAISQTKA 1505

Query: 201  LVVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHPAHQDRLQHGPKDIFTTQDEL 260
            L   K +  +  S   +G  Q+ + V +E   K Q     A+            TTQD L
Sbjct: 1506 LSQCKNRNVSTPSAFGEG--QSGLAVLKELLQKRQQKAQNAN------------TTQDPL 1551

Query: 261  LVYNKNQHQ-TKNLSQDQEHGR---KAHKISYPSSRTEERQLHHGEKSVQKDVSKGSISI 316
                 N+HQ  KN+S   EH +   +   ++ P      R     EK + K +   S+++
Sbjct: 1552 ----SNKHQPNKNISGSLEHNKANKRTRSVTSPRKPRTPRSTKQKEK-IPKLLKVDSLNL 1606

Query: 317  QTEEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSSTEERHLN-----CGEKGIQKGVSK 371
            Q   ++     +   I   D      E+  S + S + E + N      G+ G     S 
Sbjct: 1607 QNSSQLDNSVSDDSPIFFSDPGF---ESCYSLEDSLSPEHNYNFDINTIGQTGFCSFYS- 1662

Query: 372  GSISIQTEEQIHGKSQN---QVRIPSQAQEYGHKENKISYQSSSTEERRLNSGEKDVQKG 428
            GS  +  ++ +  K  +   Q   P QA E   K   +S+ +   +E + ++   D    
Sbjct: 1663 GSQFVPADQNLPQKFLSDAVQDLFPGQAIE---KNEFLSHDNQKCDEDKHHT--TDSASW 1717

Query: 429  VSKGSISIQTEEKIHGKSQNQVTIPSQDQEHGHKENKMSYQSSSTEERRLNYGGKSTQKD 488
            +  G++S +  EK         TI S +    H + K S+   +T    +       Q +
Sbjct: 1718 IRSGTLSPEIFEKS--------TIDSNENRR-HNQWKNSFHPLTTRSNSIMDSFCVQQAE 1768

Query: 489  VSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQNAKGKSGQSADS 533
               S  S      V  +  +  P PN   W   + + + GQS DS
Sbjct: 1769 DCLSEKSRLNRSSVSKEVFLSLPQPNNSDWIQGHTRKEMGQSLDS 1813


>gi|38044112 restin isoform b [Homo sapiens]
          Length = 1392

 Score = 42.0 bits (97), Expect = 0.002
 Identities = 85/453 (18%), Positives = 172/453 (37%), Gaps = 57/453 (12%)

Query: 146 QGNSPSGK-----GLSSQCSNTEKRLWVHGLSKEQASAS-----GAQKGRTQGGSQSSYV 195
           + N P+G       L  + S+ +++L V     ++   S     GA++   Q   ++ Y 
Sbjct: 488 ESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYT 547

Query: 196 LQTEELVVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHPAHQDRLQH----GPK 251
             TE+L    +  ++K  H NK +     DV     SKL+T++  +HQ  ++       K
Sbjct: 548 A-TEKLSKENESLKSKLEHANKENS----DVIALWKSKLETAI-ASHQQAMEELKVSFSK 601

Query: 252 DIFTTQDELLVYNKN--------QHQTKNLSQDQEHGRKAHKISYPSSRTEERQLHHGEK 303
            + T   E               QH+ +NL   Q+  R AH     + R +         
Sbjct: 602 GLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAK--------- 652

Query: 304 SVQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSSTEERHLNCGEK 363
            + K + +   S++       K+++Q  +  +D  +  +E +I  +     +   N   K
Sbjct: 653 -LMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTK 711

Query: 364 GIQ------KGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEERR 417
            I       K   +  + +    +   + +++++   Q  E   K+ K      + E  +
Sbjct: 712 VIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSK 771

Query: 418 LNSGEKDVQKGVSKGSISIQTEEKIHGKSQNQVTIPSQDQEHGHKENKMSYQSSSTEERR 477
            +S  +++Q    K +     +E +   SQ + T+  + Q    K  + S ++ S +   
Sbjct: 772 ASSITRELQGRELKLT---NLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSM 828

Query: 478 LNYGGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQNAKGKS---------- 527
                K  QK+   + +S  +EKL E  + ++     +D+   Q  K K           
Sbjct: 829 QETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIM 888

Query: 528 GQSADSKQDLLSHEQKGRYKQESSESHNIVITE 560
             S D+   L     + R K+   E   + +T+
Sbjct: 889 KMSGDNSSQLTKMNDELRLKERDVEELQLKLTK 921


>gi|4506751 restin isoform a [Homo sapiens]
          Length = 1427

 Score = 42.0 bits (97), Expect = 0.002
 Identities = 85/453 (18%), Positives = 172/453 (37%), Gaps = 57/453 (12%)

Query: 146 QGNSPSGK-----GLSSQCSNTEKRLWVHGLSKEQASAS-----GAQKGRTQGGSQSSYV 195
           + N P+G       L  + S+ +++L V     ++   S     GA++   Q   ++ Y 
Sbjct: 523 ESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYT 582

Query: 196 LQTEELVVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHPAHQDRLQH----GPK 251
             TE+L    +  ++K  H NK +     DV     SKL+T++  +HQ  ++       K
Sbjct: 583 A-TEKLSKENESLKSKLEHANKENS----DVIALWKSKLETAI-ASHQQAMEELKVSFSK 636

Query: 252 DIFTTQDELLVYNKN--------QHQTKNLSQDQEHGRKAHKISYPSSRTEERQLHHGEK 303
            + T   E               QH+ +NL   Q+  R AH     + R +         
Sbjct: 637 GLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAK--------- 687

Query: 304 SVQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSSTEERHLNCGEK 363
            + K + +   S++       K+++Q  +  +D  +  +E +I  +     +   N   K
Sbjct: 688 -LMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTK 746

Query: 364 GIQ------KGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEERR 417
            I       K   +  + +    +   + +++++   Q  E   K+ K      + E  +
Sbjct: 747 VIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSK 806

Query: 418 LNSGEKDVQKGVSKGSISIQTEEKIHGKSQNQVTIPSQDQEHGHKENKMSYQSSSTEERR 477
            +S  +++Q    K +     +E +   SQ + T+  + Q    K  + S ++ S +   
Sbjct: 807 ASSITRELQGRELKLT---NLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSM 863

Query: 478 LNYGGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQNAKGKS---------- 527
                K  QK+   + +S  +EKL E  + ++     +D+   Q  K K           
Sbjct: 864 QETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIM 923

Query: 528 GQSADSKQDLLSHEQKGRYKQESSESHNIVITE 560
             S D+   L     + R K+   E   + +T+
Sbjct: 924 KMSGDNSSQLTKMNDELRLKERDVEELQLKLTK 956


>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
            sapiens]
          Length = 1938

 Score = 42.0 bits (97), Expect = 0.002
 Identities = 75/383 (19%), Positives = 140/383 (36%), Gaps = 42/383 (10%)

Query: 203  VNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHPAHQDRLQHGPKDIFTTQDELLV 262
            V K++  T+N  +N       ++      +K + SL  AHQ  L     +       + +
Sbjct: 968  VEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKI 1027

Query: 263  YNKNQHQTKNLSQDQEHGRKAHKISYPSSRTEERQLHHGEKSVQK-DVSKGSISIQTEEK 321
              K + QT +L    E  +K       + R  E  L   ++S+   +  K  I  + ++K
Sbjct: 1028 NAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKK 1087

Query: 322  IHGKSQNQVTIHSQDQEHGHKENKISYQSSSTEERHLNCGEKGIQKGVSKGSISIQTEEQ 381
                SQ Q  I  +       + KI    +  EE                       EE+
Sbjct: 1088 EFELSQLQAKIDDEQVHSLQFQKKIKELQARIEE----------------------LEEE 1125

Query: 382  IHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEERRLNSGEKDVQKGVSKGSISIQTEEK 441
            I  +   + +I  Q  +   +  +IS +            E + ++      +    EE 
Sbjct: 1126 IEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEE- 1184

Query: 442  IHGKSQNQVTIPSQDQEHGHKENKMSYQSSSTEERRLNYGGKSTQKDVSQSSISFQIEKL 501
                 Q++ T  +  ++      ++  Q  + +  +     + ++  +    ++  IE L
Sbjct: 1185 --ATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEAL 1242

Query: 502  VEGKSQIQ-TPNPNQDQWSGQNAKGKSGQSADSKQDLLSHE---QKGRYKQESSE-SHNI 556
             + KS I+ T    +DQ+S   AK       D +Q  L H+   QK R + ++ E SH +
Sbjct: 1243 SKSKSNIERTCRTVEDQFSEIKAK-------DEQQTQLIHDLNMQKARLQTQNGELSHRV 1295

Query: 557  VITEHEVAQ----DDHLTQQYNE 575
               E  ++Q       LTQQ  E
Sbjct: 1296 EEKESLISQLTKSKQALTQQLEE 1318


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.305    0.122    0.336 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,558,166
Number of Sequences: 37866
Number of extensions: 1047143
Number of successful extensions: 3473
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 16
Number of HSP's successfully gapped in prelim test: 296
Number of HSP's that attempted gapping in prelim test: 2931
Number of HSP's gapped (non-prelim): 596
length of query: 582
length of database: 18,247,518
effective HSP length: 108
effective length of query: 474
effective length of database: 14,157,990
effective search space: 6710887260
effective search space used: 6710887260
T: 11
A: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (22.0 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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