Search of human proteins with 4506813

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo
sapiens]
         (1977 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo s...  3943   0.0  
gi|93141214 sodium channel, voltage-gated, type II, alpha isofor...  3102   0.0  
gi|93141212 sodium channel, voltage-gated, type II, alpha isofor...  3100   0.0  
gi|93141210 sodium channel, voltage-gated, type II, alpha isofor...  3100   0.0  
gi|115583677 sodium channel, voltage-gated, type I, alpha [Homo ...  3030   0.0  
gi|126362949 sodium channel, voltage-gated, type III, alpha isof...  3023   0.0  
gi|126362955 sodium channel, voltage-gated, type III, alpha isof...  2943   0.0  
gi|126362947 sodium channel, voltage-gated, type III, alpha isof...  2943   0.0  
gi|7657544 sodium channel, voltage gated, type VIII, alpha [Homo...  2752   0.0  
gi|237512982 voltage-gated sodium channel type V alpha isoform f...  2366   0.0  
gi|30089970 voltage-gated sodium channel type V alpha isoform b ...  2355   0.0  
gi|37622907 voltage-gated sodium channel type V alpha isoform a ...  2353   0.0  
gi|150417967 voltage-gated sodium channel type V alpha isoform c...  2350   0.0  
gi|150417969 voltage-gated sodium channel type V alpha isoform d...  2312   0.0  
gi|237512980 voltage-gated sodium channel type V alpha isoform e...  2281   0.0  
gi|110835710 sodium channel, voltage-gated, type X, alpha [Homo ...  2086   0.0  
gi|93587342 voltage-gated sodium channel type 4 alpha [Homo sapi...  1811   0.0  
gi|111378393 sodium channel, voltage-gated, type VII, alpha [Hom...  1403   0.0  
gi|115583667 sodium channel, voltage-gated, type XI, alpha [Homo...  1301   0.0  
gi|239748090 PREDICTED: similar to sodium channel, voltage-gated...   988   0.0  
gi|110349767 calcium channel, voltage-dependent, L type, alpha 1...   427   e-119
gi|192807298 calcium channel, voltage-dependent, L type, alpha 1...   422   e-117
gi|192807300 calcium channel, voltage-dependent, L type, alpha 1...   416   e-115
gi|4502527 calcium channel, voltage-dependent, L type, alpha 1D ...   416   e-115
gi|51093859 calcium channel, voltage-dependent, T type, alpha 1I...   342   2e-93
gi|21361077 calcium channel, voltage-dependent, T type, alpha 1I...   342   2e-93
gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H...   342   3e-93
gi|193788534 calcium channel, voltage-dependent, L type, alpha 1...   338   3e-92
gi|53832009 calcium channel, voltage-dependent, T type, alpha 1H...   337   5e-92
gi|193788532 calcium channel, voltage-dependent, L type, alpha 1...   337   9e-92

>gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo
            sapiens]
          Length = 1977

 Score = 3943 bits (10225), Expect = 0.0
 Identities = 1977/1977 (100%), Positives = 1977/1977 (100%)

Query: 1    MAMLPPPGPQSFVHFTKQSLALIEQRIAERKSKEPKEEKKDDDEEAPKPSSDLEAGKQLP 60
            MAMLPPPGPQSFVHFTKQSLALIEQRIAERKSKEPKEEKKDDDEEAPKPSSDLEAGKQLP
Sbjct: 1    MAMLPPPGPQSFVHFTKQSLALIEQRIAERKSKEPKEEKKDDDEEAPKPSSDLEAGKQLP 60

Query: 61   FIYGDIPPGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRISI 120
            FIYGDIPPGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRISI
Sbjct: 61   FIYGDIPPGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRISI 120

Query: 121  KILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKILARGFCVGE 180
            KILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKILARGFCVGE
Sbjct: 121  KILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKILARGFCVGE 180

Query: 181  FTFLRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQ 240
            FTFLRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQ
Sbjct: 181  FTFLRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQ 240

Query: 241  SVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETLESIMNTLESEEDFR 300
            SVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETLESIMNTLESEEDFR
Sbjct: 241  SVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETLESIMNTLESEEDFR 300

Query: 301  KYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQ 360
            KYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQ
Sbjct: 301  KYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQ 360

Query: 361  DYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANIEEAKQKE 420
            DYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANIEEAKQKE
Sbjct: 361  DYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANIEEAKQKE 420

Query: 421  LEFQQMLDRLKKEQEEAEAIAAAAAEYTSIRRSRIMGLSESSSETSKLSSKSAKERRNRR 480
            LEFQQMLDRLKKEQEEAEAIAAAAAEYTSIRRSRIMGLSESSSETSKLSSKSAKERRNRR
Sbjct: 421  LEFQQMLDRLKKEQEEAEAIAAAAAEYTSIRRSRIMGLSESSSETSKLSSKSAKERRNRR 480

Query: 481  KKKNQKKLSSGEEKGDAEKLSKSESEDSIRRKSFHLGVEGHRRAHEKRLSTPNQSPLSIR 540
            KKKNQKKLSSGEEKGDAEKLSKSESEDSIRRKSFHLGVEGHRRAHEKRLSTPNQSPLSIR
Sbjct: 481  KKKNQKKLSSGEEKGDAEKLSKSESEDSIRRKSFHLGVEGHRRAHEKRLSTPNQSPLSIR 540

Query: 541  GSLFSARRSSRTSLFSFKGRGRDIGSETEFADDEHSIFGDNESRRGSLFVPHRPQERRSS 600
            GSLFSARRSSRTSLFSFKGRGRDIGSETEFADDEHSIFGDNESRRGSLFVPHRPQERRSS
Sbjct: 541  GSLFSARRSSRTSLFSFKGRGRDIGSETEFADDEHSIFGDNESRRGSLFVPHRPQERRSS 600

Query: 601  NISQASRSPPMLPVNGKMHSAVDCNGVVSLVDGRSALMLPNGQLLPEGTTNQIHKKRRCS 660
            NISQASRSPPMLPVNGKMHSAVDCNGVVSLVDGRSALMLPNGQLLPEGTTNQIHKKRRCS
Sbjct: 601  NISQASRSPPMLPVNGKMHSAVDCNGVVSLVDGRSALMLPNGQLLPEGTTNQIHKKRRCS 660

Query: 661  SYLLSEDMLNDPNLRQRAMSRASILTNTVEELEESRQKCPPWWYRFAHKFLIWNCSPYWI 720
            SYLLSEDMLNDPNLRQRAMSRASILTNTVEELEESRQKCPPWWYRFAHKFLIWNCSPYWI
Sbjct: 661  SYLLSEDMLNDPNLRQRAMSRASILTNTVEELEESRQKCPPWWYRFAHKFLIWNCSPYWI 720

Query: 721  KFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAIGNLVFTGIFAAEM 780
            KFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAIGNLVFTGIFAAEM
Sbjct: 721  KFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAIGNLVFTGIFAAEM 780

Query: 781  VLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADVEGLSVLRSFRLLRVFKLAKSWPT 840
            VLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADVEGLSVLRSFRLLRVFKLAKSWPT
Sbjct: 781  VLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADVEGLSVLRSFRLLRVFKLAKSWPT 840

Query: 841  LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMN 900
            LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMN
Sbjct: 841  LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMN 900

Query: 901  DFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVYMMVMVIGNLVVLNLFLALLLSSF 960
            DFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVYMMVMVIGNLVVLNLFLALLLSSF
Sbjct: 901  DFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVYMMVMVIGNLVVLNLFLALLLSSF 960

Query: 961  SSDNLTAIEEDPDANNLQIAVTRIKKGINYVKQTLREFILKAFSKKPKISREIRQAEDLN 1020
            SSDNLTAIEEDPDANNLQIAVTRIKKGINYVKQTLREFILKAFSKKPKISREIRQAEDLN
Sbjct: 961  SSDNLTAIEEDPDANNLQIAVTRIKKGINYVKQTLREFILKAFSKKPKISREIRQAEDLN 1020

Query: 1021 TKKENYISNHTLAEMSKGHNFLKEKDKISGFGSSVDKHLMEDSDGQSFIHNPSLTVTVPI 1080
            TKKENYISNHTLAEMSKGHNFLKEKDKISGFGSSVDKHLMEDSDGQSFIHNPSLTVTVPI
Sbjct: 1021 TKKENYISNHTLAEMSKGHNFLKEKDKISGFGSSVDKHLMEDSDGQSFIHNPSLTVTVPI 1080

Query: 1081 APGESDLENMNAEELSSDSDSEYSKVRLNRSSSSECSTVDNPLPGEGEEAEAEPMNSDEP 1140
            APGESDLENMNAEELSSDSDSEYSKVRLNRSSSSECSTVDNPLPGEGEEAEAEPMNSDEP
Sbjct: 1081 APGESDLENMNAEELSSDSDSEYSKVRLNRSSSSECSTVDNPLPGEGEEAEAEPMNSDEP 1140

Query: 1141 EACFTDGCVRRFSCCQVNIESGKGKIWWNIRKTCYKIVEHSWFESFIVLMILLSSGALAF 1200
            EACFTDGCVRRFSCCQVNIESGKGKIWWNIRKTCYKIVEHSWFESFIVLMILLSSGALAF
Sbjct: 1141 EACFTDGCVRRFSCCQVNIESGKGKIWWNIRKTCYKIVEHSWFESFIVLMILLSSGALAF 1200

Query: 1201 EDIYIERKKTIKIILEYADKIFTYIFILEMLLKWIAYGYKTYFTNAWCWLDFLIVDVSLV 1260
            EDIYIERKKTIKIILEYADKIFTYIFILEMLLKWIAYGYKTYFTNAWCWLDFLIVDVSLV
Sbjct: 1201 EDIYIERKKTIKIILEYADKIFTYIFILEMLLKWIAYGYKTYFTNAWCWLDFLIVDVSLV 1260

Query: 1261 TLVANTLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIF 1320
            TLVANTLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIF
Sbjct: 1261 TLVANTLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIF 1320

Query: 1321 WLIFSIMGVNLFAGKFYECINTTDGSRFPASQVPNRSECFALMNVSQNVRWKNLKVNFDN 1380
            WLIFSIMGVNLFAGKFYECINTTDGSRFPASQVPNRSECFALMNVSQNVRWKNLKVNFDN
Sbjct: 1321 WLIFSIMGVNLFAGKFYECINTTDGSRFPASQVPNRSECFALMNVSQNVRWKNLKVNFDN 1380

Query: 1381 VGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNL 1440
            VGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNL
Sbjct: 1381 VGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNL 1440

Query: 1441 FIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKIQGCIFDL 1500
            FIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKIQGCIFDL
Sbjct: 1441 FIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKIQGCIFDL 1500

Query: 1501 VTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTGECVLKLISLRH 1560
            VTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTGECVLKLISLRH
Sbjct: 1501 VTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTGECVLKLISLRH 1560

Query: 1561 YYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRLARIGRILRLVKGAKGIR 1620
            YYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRLARIGRILRLVKGAKGIR
Sbjct: 1561 YYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRLARIGRILRLVKGAKGIR 1620

Query: 1621 TLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEDGINDMFNFETFGNSMICL 1680
            TLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEDGINDMFNFETFGNSMICL
Sbjct: 1621 TLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEDGINDMFNFETFGNSMICL 1680

Query: 1681 FQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVV 1740
            FQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVV
Sbjct: 1681 FQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVV 1740

Query: 1741 VNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDP 1800
            VNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDP
Sbjct: 1741 VNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDP 1800

Query: 1801 PLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDSLRSQMEERFMSAN 1860
            PLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDSLRSQMEERFMSAN
Sbjct: 1801 PLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDSLRSQMEERFMSAN 1860

Query: 1861 PSKVSYEPITTTLKRKQEDVSATVIQRAYRRYRLRQNVKNISSIYIKDGDRDDDLLNKKD 1920
            PSKVSYEPITTTLKRKQEDVSATVIQRAYRRYRLRQNVKNISSIYIKDGDRDDDLLNKKD
Sbjct: 1861 PSKVSYEPITTTLKRKQEDVSATVIQRAYRRYRLRQNVKNISSIYIKDGDRDDDLLNKKD 1920

Query: 1921 MAFDNVNENSSPEKTDATSSTTSPPSYDSVTKPDKEKYEQDRTEKEDKGKDSKESKK 1977
            MAFDNVNENSSPEKTDATSSTTSPPSYDSVTKPDKEKYEQDRTEKEDKGKDSKESKK
Sbjct: 1921 MAFDNVNENSSPEKTDATSSTTSPPSYDSVTKPDKEKYEQDRTEKEDKGKDSKESKK 1977


>gi|93141214 sodium channel, voltage-gated, type II, alpha isoform 2
            [Homo sapiens]
          Length = 2005

 Score = 3102 bits (8043), Expect = 0.0
 Identities = 1574/2006 (78%), Positives = 1746/2006 (87%), Gaps = 34/2006 (1%)

Query: 2    AMLPPPGPQSFVHFTKQSLALIEQRIAERKSKEPKEEKKD-DDEEAPKPSSDLEAGKQLP 60
            ++L PPGP SF  FT++SLA IEQRIAE K+K PK+E+KD DDE  PKP+SDLEAGK LP
Sbjct: 4    SVLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGKSLP 63

Query: 61   FIYGDIPPGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRISI 120
            FIYGDIPP MVS PLEDLDPYY +KKTFIVLNKGK I RF+ATPALY+L+PF+P+R+++I
Sbjct: 64   FIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRKLAI 123

Query: 121  KILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKILARGFCVGE 180
            KILVHSLF+MLIMCTILTNC+FMTM+NPPDWTKNVEYTFTGIYTFESL+KILARGFC+ +
Sbjct: 124  KILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLED 183

Query: 181  FTFLRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQ 240
            FTFLRDPWNWLDF VI FAY+TEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQ
Sbjct: 184  FTFLRDPWNWLDFTVITFAYVTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQ 243

Query: 241  SVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKC-----------------FRNSLENN 283
            SVKKLSDVMILTVFCLSVFALIGLQLFMGNL++KC                 F NSL+ N
Sbjct: 244  SVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSLDGN 303

Query: 284  ETL----ESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDY 339
             T      SI N  E  ED + +FY+LEG  DALLCG S+D+GQCPEGY CVK GRNP+Y
Sbjct: 304  GTTFNRTVSIFNWDEYIED-KSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNPNY 362

Query: 340  GYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILA 399
            GYTSFDTFSWAFL+LFRLMTQD+WENLYQ TLRAAGKTYMIFFV+VIFLGSFYLINLILA
Sbjct: 363  GYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILA 422

Query: 400  VVAMAYEEQNQANIEEAKQKELEFQQMLDRLKKEQEEAEAIAAAA-AEYTSIRRSRIMGL 458
            VVAMAYEEQNQA +EEA+QKE EFQQML++LKK+QEEA+A AAAA AE      +  +G+
Sbjct: 423  VVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGIGV 482

Query: 459  -SESSSETSKLSSKSAKERRNRRKKKNQKKLSSGEEKGDAEKLSKSESEDSIRRKSFHLG 517
             SESSS  SKLSSKS KE +NRRKKK QK+ S  EEK D  ++ KSESEDSIRRK F   
Sbjct: 483  FSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEEKND--RVRKSESEDSIRRKGFRFS 540

Query: 518  VEGHRRAHEKRLSTPNQSPLSIRGSLFSARRSSRTSLFSFKGRGRDIGSETEFADDEHSI 577
            +EG R  +EKR S+P+QS LSIRGSLFS RR+SR SLFSF+GR +DIGSE +FADDEHS 
Sbjct: 541  LEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHST 600

Query: 578  FGDNESRRGSLFVPHRPQERRSSNISQASRSP---PMLPVNGKMHSAVDCNGVVSLVDGR 634
            F DN+SRR SLFVPHR  ERR SN+SQASR+    P+LP+NGKMHSAVDCNGVVSLV G 
Sbjct: 601  FEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVGGP 660

Query: 635  SALMLPNGQLLPEGTTNQIH-KKRRCSSYLLSEDMLNDPNLRQRAMSRASILTNTVEELE 693
            S L    GQLLPEGTT +   +KRR SSY +S D+L DP  RQRAMS ASILTNT+EELE
Sbjct: 661  STLTSA-GQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEELE 719

Query: 694  ESRQKCPPWWYRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAME 753
            ESRQKCPP WY+FA+  LIW+C   W+K K  +  +VMDPFVDLAITICIVLNTLFMAME
Sbjct: 720  ESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAME 779

Query: 754  HHPMTEEFKNVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELF 813
            H+PMTE+F +VL++GNLVFTGIF AEM LK+IAMDPY YFQ GWNIFD  IV+LSL+EL 
Sbjct: 780  HYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELG 839

Query: 814  LADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVG 873
            LA+VEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVG
Sbjct: 840  LANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVG 899

Query: 874  MQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMC 933
            MQLFGKSYKECVCKI++DC LPRWHM+DFFHSFLIVFRVLCGEWIETMWDCMEVAGQ MC
Sbjct: 900  MQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMC 959

Query: 934  LIVYMMVMVIGNLVVLNLFLALLLSSFSSDNLTAIEEDPDANNLQIAVTRIKKGINYVKQ 993
            L V+MMVMVIGNLVVLNLFLALLLSSFSSDNL A ++D + NNLQIAV R++KGI++VK+
Sbjct: 960  LTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKR 1019

Query: 994  TLREFILKAFSKKPKISREIRQAEDLNTKKENYISNHTLAEMSKGHNFLKEKD-KISGFG 1052
             +REFI KAF +K K   EI+  EDLN KK++ ISNHT  E+ K  N+LK+ +   SG G
Sbjct: 1020 KIREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSGIG 1079

Query: 1053 SSVDKHLMEDSDGQSFIHNPSLTVTVPIAPGESDLENMNAEELSSDSDSEYSKVRLNRSS 1112
            SSV+K+++++SD  SFI+NPSLTVTVPIA GESD EN+N EE SS+SD E SK +LN +S
Sbjct: 1080 SSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKEKLNATS 1139

Query: 1113 SSECSTVDNPLPGEGEEAEAEPMNSDEPEACFTDGCVRRFSCCQVNIESGKGKIWWNIRK 1172
            SSE STVD   P EGE+ E EP  S EPEACFT+ CVR+F CCQ++IE GKGK+WWN+RK
Sbjct: 1140 SSEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRK 1199

Query: 1173 TCYKIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILEMLL 1232
            TCYKIVEH+WFE+FIV MILLSSGALAFEDIYIE++KTIK +LEYADK+FTYIFILEMLL
Sbjct: 1200 TCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLL 1259

Query: 1233 KWIAYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSR 1292
            KW+AYG++ YFTNAWCWLDFLIVDVSLV+L AN LGYS+LG IKSLRTLRALRPLRALSR
Sbjct: 1260 KWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSR 1319

Query: 1293 FEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDGSRFPASQ 1352
            FEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFY CIN T G  F  S 
Sbjct: 1320 FEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSV 1379

Query: 1353 VPNRSECFALMNVSQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDK 1412
            V N SEC AL+  +Q  RWKN+KVNFDNVGLGYLSLLQVATFKGW  IMYAAVDS NV+ 
Sbjct: 1380 VNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVEL 1439

Query: 1413 QPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYN 1472
            QPKYE +LYMY+YFV+FIIFGSFFTLNLFIGVIIDNFNQQKKK GGQDIFMTEEQKKYYN
Sbjct: 1440 QPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYN 1499

Query: 1473 AMKKLGSKKPQKPIPRPGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHM 1532
            AMKKLGSKKPQKPIPRP NK QG +FD VT Q FDISIM+LICLNMVTMMVE + QSQ M
Sbjct: 1500 AMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEM 1559

Query: 1533 TEVLYWINVVFIILFTGECVLKLISLRHYYFTVGWNIFDFVVVIISIVGMFLADLIETYF 1592
            T +LYWIN+VFI+LFTGECVLKLISLR+YYFT+GWNIFDFVVVI+SIVGMFLA+LIE YF
Sbjct: 1560 TNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYF 1619

Query: 1593 VSPTLFRVIRLARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM 1652
            VSPTLFRVIRLARIGRILRL+KGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM
Sbjct: 1620 VSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM 1679

Query: 1653 SNFAYVKKEDGINDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPG 1712
            SNFAYVK+E GI+DMFNFETFGNSMICLFQITTSAGWDGLLAPILNS PPDCDP K HPG
Sbjct: 1680 SNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPG 1739

Query: 1713 SSVEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFY 1772
            SSV+GDCGNPSVGIF+FVSYIIISFLVVVNMYIAVILENFSVATEES EPLSEDDFEMFY
Sbjct: 1740 SSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFY 1799

Query: 1773 EVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILF 1832
            EVWEKFDPDATQFIEF+KLSDFA ALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILF
Sbjct: 1800 EVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILF 1859

Query: 1833 AFTKRVLGESGEMDSLRSQMEERFMSANPSKVSYEPITTTLKRKQEDVSATVIQRAYRRY 1892
            AFTKRVLGESGEMD+LR QMEERFM++NPSKVSYEPITTTLKRKQE+VSA +IQRAYRRY
Sbjct: 1860 AFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRAYRRY 1919

Query: 1893 RLRQNVKNISSIYIKD-GDRDDDLLNKKDMAFDNVNENSSPEKTDATSSTTSPPSYDSVT 1951
             L+Q VK +SSIY KD G   D    K+D   D +NENS+PEKTD T STTSPPSYDSVT
Sbjct: 1920 LLKQKVKKVSSIYKKDKGKECDGTPIKEDTLIDKLNENSTPEKTDMTPSTTSPPSYDSVT 1979

Query: 1952 KPDKEKYEQDRTEKEDKGKDSKESKK 1977
            KP+KEK+E+D++EKEDKGKD +ESKK
Sbjct: 1980 KPEKEKFEKDKSEKEDKGKDIRESKK 2005


>gi|93141212 sodium channel, voltage-gated, type II, alpha isoform 1
            [Homo sapiens]
          Length = 2005

 Score = 3100 bits (8038), Expect = 0.0
 Identities = 1573/2006 (78%), Positives = 1746/2006 (87%), Gaps = 34/2006 (1%)

Query: 2    AMLPPPGPQSFVHFTKQSLALIEQRIAERKSKEPKEEKKD-DDEEAPKPSSDLEAGKQLP 60
            ++L PPGP SF  FT++SLA IEQRIAE K+K PK+E+KD DDE  PKP+SDLEAGK LP
Sbjct: 4    SVLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGKSLP 63

Query: 61   FIYGDIPPGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRISI 120
            FIYGDIPP MVS PLEDLDPYY +KKTFIVLNKGK I RF+ATPALY+L+PF+P+R+++I
Sbjct: 64   FIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRKLAI 123

Query: 121  KILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKILARGFCVGE 180
            KILVHSLF+MLIMCTILTNC+FMTM+NPPDWTKNVEYTFTGIYTFESL+KILARGFC+ +
Sbjct: 124  KILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLED 183

Query: 181  FTFLRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQ 240
            FTFLRDPWNWLDF VI FAY+TEFV+LGNVSALRTFRVLRALKTISVIPGLKTIVGALIQ
Sbjct: 184  FTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQ 243

Query: 241  SVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKC-----------------FRNSLENN 283
            SVKKLSDVMILTVFCLSVFALIGLQLFMGNL++KC                 F NSL+ N
Sbjct: 244  SVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSLDGN 303

Query: 284  ETL----ESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDY 339
             T      SI N  E  ED + +FY+LEG  DALLCG S+D+GQCPEGY CVK GRNP+Y
Sbjct: 304  GTTFNRTVSIFNWDEYIED-KSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNPNY 362

Query: 340  GYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILA 399
            GYTSFDTFSWAFL+LFRLMTQD+WENLYQ TLRAAGKTYMIFFV+VIFLGSFYLINLILA
Sbjct: 363  GYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILA 422

Query: 400  VVAMAYEEQNQANIEEAKQKELEFQQMLDRLKKEQEEAEAIAAAA-AEYTSIRRSRIMGL 458
            VVAMAYEEQNQA +EEA+QKE EFQQML++LKK+QEEA+A AAAA AE      +  +G+
Sbjct: 423  VVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGIGV 482

Query: 459  -SESSSETSKLSSKSAKERRNRRKKKNQKKLSSGEEKGDAEKLSKSESEDSIRRKSFHLG 517
             SESSS  SKLSSKS KE +NRRKKK QK+ S  EEK D  ++ KSESEDSIRRK F   
Sbjct: 483  FSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEEKND--RVRKSESEDSIRRKGFRFS 540

Query: 518  VEGHRRAHEKRLSTPNQSPLSIRGSLFSARRSSRTSLFSFKGRGRDIGSETEFADDEHSI 577
            +EG R  +EKR S+P+QS LSIRGSLFS RR+SR SLFSF+GR +DIGSE +FADDEHS 
Sbjct: 541  LEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHST 600

Query: 578  FGDNESRRGSLFVPHRPQERRSSNISQASRSP---PMLPVNGKMHSAVDCNGVVSLVDGR 634
            F DN+SRR SLFVPHR  ERR SN+SQASR+    P+LP+NGKMHSAVDCNGVVSLV G 
Sbjct: 601  FEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVGGP 660

Query: 635  SALMLPNGQLLPEGTTNQIH-KKRRCSSYLLSEDMLNDPNLRQRAMSRASILTNTVEELE 693
            S L    GQLLPEGTT +   +KRR SSY +S D+L DP  RQRAMS ASILTNT+EELE
Sbjct: 661  STLTSA-GQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEELE 719

Query: 694  ESRQKCPPWWYRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAME 753
            ESRQKCPP WY+FA+  LIW+C   W+K K  +  +VMDPFVDLAITICIVLNTLFMAME
Sbjct: 720  ESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAME 779

Query: 754  HHPMTEEFKNVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELF 813
            H+PMTE+F +VL++GNLVFTGIF AEM LK+IAMDPY YFQ GWNIFD  IV+LSL+EL 
Sbjct: 780  HYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELG 839

Query: 814  LADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVG 873
            LA+VEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVG
Sbjct: 840  LANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVG 899

Query: 874  MQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMC 933
            MQLFGKSYKECVCKI++DC LPRWHM+DFFHSFLIVFRVLCGEWIETMWDCMEVAGQ MC
Sbjct: 900  MQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMC 959

Query: 934  LIVYMMVMVIGNLVVLNLFLALLLSSFSSDNLTAIEEDPDANNLQIAVTRIKKGINYVKQ 993
            L V+MMVMVIGNLVVLNLFLALLLSSFSSDNL A ++D + NNLQIAV R++KGI++VK+
Sbjct: 960  LTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKR 1019

Query: 994  TLREFILKAFSKKPKISREIRQAEDLNTKKENYISNHTLAEMSKGHNFLKEKD-KISGFG 1052
             +REFI KAF +K K   EI+  EDLN KK++ ISNHT  E+ K  N+LK+ +   SG G
Sbjct: 1020 KIREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSGIG 1079

Query: 1053 SSVDKHLMEDSDGQSFIHNPSLTVTVPIAPGESDLENMNAEELSSDSDSEYSKVRLNRSS 1112
            SSV+K+++++SD  SFI+NPSLTVTVPIA GESD EN+N EE SS+SD E SK +LN +S
Sbjct: 1080 SSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKEKLNATS 1139

Query: 1113 SSECSTVDNPLPGEGEEAEAEPMNSDEPEACFTDGCVRRFSCCQVNIESGKGKIWWNIRK 1172
            SSE STVD   P EGE+ E EP  S EPEACFT+ CVR+F CCQ++IE GKGK+WWN+RK
Sbjct: 1140 SSEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRK 1199

Query: 1173 TCYKIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILEMLL 1232
            TCYKIVEH+WFE+FIV MILLSSGALAFEDIYIE++KTIK +LEYADK+FTYIFILEMLL
Sbjct: 1200 TCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLL 1259

Query: 1233 KWIAYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSR 1292
            KW+AYG++ YFTNAWCWLDFLIVDVSLV+L AN LGYS+LG IKSLRTLRALRPLRALSR
Sbjct: 1260 KWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSR 1319

Query: 1293 FEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDGSRFPASQ 1352
            FEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFY CIN T G  F  S 
Sbjct: 1320 FEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSV 1379

Query: 1353 VPNRSECFALMNVSQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDK 1412
            V N SEC AL+  +Q  RWKN+KVNFDNVGLGYLSLLQVATFKGW  IMYAAVDS NV+ 
Sbjct: 1380 VNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVEL 1439

Query: 1413 QPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYN 1472
            QPKYE +LYMY+YFV+FIIFGSFFTLNLFIGVIIDNFNQQKKK GGQDIFMTEEQKKYYN
Sbjct: 1440 QPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYN 1499

Query: 1473 AMKKLGSKKPQKPIPRPGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHM 1532
            AMKKLGSKKPQKPIPRP NK QG +FD VT Q FDISIM+LICLNMVTMMVE + QSQ M
Sbjct: 1500 AMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEM 1559

Query: 1533 TEVLYWINVVFIILFTGECVLKLISLRHYYFTVGWNIFDFVVVIISIVGMFLADLIETYF 1592
            T +LYWIN+VFI+LFTGECVLKLISLR+YYFT+GWNIFDFVVVI+SIVGMFLA+LIE YF
Sbjct: 1560 TNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYF 1619

Query: 1593 VSPTLFRVIRLARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM 1652
            VSPTLFRVIRLARIGRILRL+KGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM
Sbjct: 1620 VSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM 1679

Query: 1653 SNFAYVKKEDGINDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPG 1712
            SNFAYVK+E GI+DMFNFETFGNSMICLFQITTSAGWDGLLAPILNS PPDCDP K HPG
Sbjct: 1680 SNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPG 1739

Query: 1713 SSVEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFY 1772
            SSV+GDCGNPSVGIF+FVSYIIISFLVVVNMYIAVILENFSVATEES EPLSEDDFEMFY
Sbjct: 1740 SSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFY 1799

Query: 1773 EVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILF 1832
            EVWEKFDPDATQFIEF+KLSDFA ALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILF
Sbjct: 1800 EVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILF 1859

Query: 1833 AFTKRVLGESGEMDSLRSQMEERFMSANPSKVSYEPITTTLKRKQEDVSATVIQRAYRRY 1892
            AFTKRVLGESGEMD+LR QMEERFM++NPSKVSYEPITTTLKRKQE+VSA +IQRAYRRY
Sbjct: 1860 AFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRAYRRY 1919

Query: 1893 RLRQNVKNISSIYIKD-GDRDDDLLNKKDMAFDNVNENSSPEKTDATSSTTSPPSYDSVT 1951
             L+Q VK +SSIY KD G   D    K+D   D +NENS+PEKTD T STTSPPSYDSVT
Sbjct: 1920 LLKQKVKKVSSIYKKDKGKECDGTPIKEDTLIDKLNENSTPEKTDMTPSTTSPPSYDSVT 1979

Query: 1952 KPDKEKYEQDRTEKEDKGKDSKESKK 1977
            KP+KEK+E+D++EKEDKGKD +ESKK
Sbjct: 1980 KPEKEKFEKDKSEKEDKGKDIRESKK 2005


>gi|93141210 sodium channel, voltage-gated, type II, alpha isoform 1
            [Homo sapiens]
          Length = 2005

 Score = 3100 bits (8038), Expect = 0.0
 Identities = 1573/2006 (78%), Positives = 1746/2006 (87%), Gaps = 34/2006 (1%)

Query: 2    AMLPPPGPQSFVHFTKQSLALIEQRIAERKSKEPKEEKKD-DDEEAPKPSSDLEAGKQLP 60
            ++L PPGP SF  FT++SLA IEQRIAE K+K PK+E+KD DDE  PKP+SDLEAGK LP
Sbjct: 4    SVLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGKSLP 63

Query: 61   FIYGDIPPGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRISI 120
            FIYGDIPP MVS PLEDLDPYY +KKTFIVLNKGK I RF+ATPALY+L+PF+P+R+++I
Sbjct: 64   FIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRKLAI 123

Query: 121  KILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKILARGFCVGE 180
            KILVHSLF+MLIMCTILTNC+FMTM+NPPDWTKNVEYTFTGIYTFESL+KILARGFC+ +
Sbjct: 124  KILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLED 183

Query: 181  FTFLRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQ 240
            FTFLRDPWNWLDF VI FAY+TEFV+LGNVSALRTFRVLRALKTISVIPGLKTIVGALIQ
Sbjct: 184  FTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQ 243

Query: 241  SVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKC-----------------FRNSLENN 283
            SVKKLSDVMILTVFCLSVFALIGLQLFMGNL++KC                 F NSL+ N
Sbjct: 244  SVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSLDGN 303

Query: 284  ETL----ESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDY 339
             T      SI N  E  ED + +FY+LEG  DALLCG S+D+GQCPEGY CVK GRNP+Y
Sbjct: 304  GTTFNRTVSIFNWDEYIED-KSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNPNY 362

Query: 340  GYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILA 399
            GYTSFDTFSWAFL+LFRLMTQD+WENLYQ TLRAAGKTYMIFFV+VIFLGSFYLINLILA
Sbjct: 363  GYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILA 422

Query: 400  VVAMAYEEQNQANIEEAKQKELEFQQMLDRLKKEQEEAEAIAAAA-AEYTSIRRSRIMGL 458
            VVAMAYEEQNQA +EEA+QKE EFQQML++LKK+QEEA+A AAAA AE      +  +G+
Sbjct: 423  VVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGIGV 482

Query: 459  -SESSSETSKLSSKSAKERRNRRKKKNQKKLSSGEEKGDAEKLSKSESEDSIRRKSFHLG 517
             SESSS  SKLSSKS KE +NRRKKK QK+ S  EEK D  ++ KSESEDSIRRK F   
Sbjct: 483  FSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEEKND--RVRKSESEDSIRRKGFRFS 540

Query: 518  VEGHRRAHEKRLSTPNQSPLSIRGSLFSARRSSRTSLFSFKGRGRDIGSETEFADDEHSI 577
            +EG R  +EKR S+P+QS LSIRGSLFS RR+SR SLFSF+GR +DIGSE +FADDEHS 
Sbjct: 541  LEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHST 600

Query: 578  FGDNESRRGSLFVPHRPQERRSSNISQASRSP---PMLPVNGKMHSAVDCNGVVSLVDGR 634
            F DN+SRR SLFVPHR  ERR SN+SQASR+    P+LP+NGKMHSAVDCNGVVSLV G 
Sbjct: 601  FEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVGGP 660

Query: 635  SALMLPNGQLLPEGTTNQIH-KKRRCSSYLLSEDMLNDPNLRQRAMSRASILTNTVEELE 693
            S L    GQLLPEGTT +   +KRR SSY +S D+L DP  RQRAMS ASILTNT+EELE
Sbjct: 661  STLTSA-GQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEELE 719

Query: 694  ESRQKCPPWWYRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAME 753
            ESRQKCPP WY+FA+  LIW+C   W+K K  +  +VMDPFVDLAITICIVLNTLFMAME
Sbjct: 720  ESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAME 779

Query: 754  HHPMTEEFKNVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELF 813
            H+PMTE+F +VL++GNLVFTGIF AEM LK+IAMDPY YFQ GWNIFD  IV+LSL+EL 
Sbjct: 780  HYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELG 839

Query: 814  LADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVG 873
            LA+VEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVG
Sbjct: 840  LANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVG 899

Query: 874  MQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMC 933
            MQLFGKSYKECVCKI++DC LPRWHM+DFFHSFLIVFRVLCGEWIETMWDCMEVAGQ MC
Sbjct: 900  MQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMC 959

Query: 934  LIVYMMVMVIGNLVVLNLFLALLLSSFSSDNLTAIEEDPDANNLQIAVTRIKKGINYVKQ 993
            L V+MMVMVIGNLVVLNLFLALLLSSFSSDNL A ++D + NNLQIAV R++KGI++VK+
Sbjct: 960  LTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKR 1019

Query: 994  TLREFILKAFSKKPKISREIRQAEDLNTKKENYISNHTLAEMSKGHNFLKEKD-KISGFG 1052
             +REFI KAF +K K   EI+  EDLN KK++ ISNHT  E+ K  N+LK+ +   SG G
Sbjct: 1020 KIREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSGIG 1079

Query: 1053 SSVDKHLMEDSDGQSFIHNPSLTVTVPIAPGESDLENMNAEELSSDSDSEYSKVRLNRSS 1112
            SSV+K+++++SD  SFI+NPSLTVTVPIA GESD EN+N EE SS+SD E SK +LN +S
Sbjct: 1080 SSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKEKLNATS 1139

Query: 1113 SSECSTVDNPLPGEGEEAEAEPMNSDEPEACFTDGCVRRFSCCQVNIESGKGKIWWNIRK 1172
            SSE STVD   P EGE+ E EP  S EPEACFT+ CVR+F CCQ++IE GKGK+WWN+RK
Sbjct: 1140 SSEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRK 1199

Query: 1173 TCYKIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILEMLL 1232
            TCYKIVEH+WFE+FIV MILLSSGALAFEDIYIE++KTIK +LEYADK+FTYIFILEMLL
Sbjct: 1200 TCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLL 1259

Query: 1233 KWIAYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSR 1292
            KW+AYG++ YFTNAWCWLDFLIVDVSLV+L AN LGYS+LG IKSLRTLRALRPLRALSR
Sbjct: 1260 KWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSR 1319

Query: 1293 FEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDGSRFPASQ 1352
            FEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFY CIN T G  F  S 
Sbjct: 1320 FEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSV 1379

Query: 1353 VPNRSECFALMNVSQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDK 1412
            V N SEC AL+  +Q  RWKN+KVNFDNVGLGYLSLLQVATFKGW  IMYAAVDS NV+ 
Sbjct: 1380 VNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVEL 1439

Query: 1413 QPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYN 1472
            QPKYE +LYMY+YFV+FIIFGSFFTLNLFIGVIIDNFNQQKKK GGQDIFMTEEQKKYYN
Sbjct: 1440 QPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYN 1499

Query: 1473 AMKKLGSKKPQKPIPRPGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHM 1532
            AMKKLGSKKPQKPIPRP NK QG +FD VT Q FDISIM+LICLNMVTMMVE + QSQ M
Sbjct: 1500 AMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEM 1559

Query: 1533 TEVLYWINVVFIILFTGECVLKLISLRHYYFTVGWNIFDFVVVIISIVGMFLADLIETYF 1592
            T +LYWIN+VFI+LFTGECVLKLISLR+YYFT+GWNIFDFVVVI+SIVGMFLA+LIE YF
Sbjct: 1560 TNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYF 1619

Query: 1593 VSPTLFRVIRLARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM 1652
            VSPTLFRVIRLARIGRILRL+KGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM
Sbjct: 1620 VSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM 1679

Query: 1653 SNFAYVKKEDGINDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPG 1712
            SNFAYVK+E GI+DMFNFETFGNSMICLFQITTSAGWDGLLAPILNS PPDCDP K HPG
Sbjct: 1680 SNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPG 1739

Query: 1713 SSVEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFY 1772
            SSV+GDCGNPSVGIF+FVSYIIISFLVVVNMYIAVILENFSVATEES EPLSEDDFEMFY
Sbjct: 1740 SSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFY 1799

Query: 1773 EVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILF 1832
            EVWEKFDPDATQFIEF+KLSDFA ALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILF
Sbjct: 1800 EVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILF 1859

Query: 1833 AFTKRVLGESGEMDSLRSQMEERFMSANPSKVSYEPITTTLKRKQEDVSATVIQRAYRRY 1892
            AFTKRVLGESGEMD+LR QMEERFM++NPSKVSYEPITTTLKRKQE+VSA +IQRAYRRY
Sbjct: 1860 AFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRAYRRY 1919

Query: 1893 RLRQNVKNISSIYIKD-GDRDDDLLNKKDMAFDNVNENSSPEKTDATSSTTSPPSYDSVT 1951
             L+Q VK +SSIY KD G   D    K+D   D +NENS+PEKTD T STTSPPSYDSVT
Sbjct: 1920 LLKQKVKKVSSIYKKDKGKECDGTPIKEDTLIDKLNENSTPEKTDMTPSTTSPPSYDSVT 1979

Query: 1952 KPDKEKYEQDRTEKEDKGKDSKESKK 1977
            KP+KEK+E+D++EKEDKGKD +ESKK
Sbjct: 1980 KPEKEKFEKDKSEKEDKGKDIRESKK 2005


>gi|115583677 sodium channel, voltage-gated, type I, alpha [Homo
            sapiens]
          Length = 1998

 Score = 3030 bits (7856), Expect = 0.0
 Identities = 1533/1997 (76%), Positives = 1725/1997 (86%), Gaps = 32/1997 (1%)

Query: 3    MLPPPGPQSFVHFTKQSLALIEQRIAERKSKEPKEEKKDDDEEAPKPSSDLEAGKQLPFI 62
            +L PPGP SF  FT++SLA IE+RIAE K+K PK +KKDDDE  PKP+SDLEAGK LPFI
Sbjct: 5    VLVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPDKKDDDENGPKPNSDLEAGKNLPFI 64

Query: 63   YGDIPPGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRISIKI 122
            YGDIPP MVSEPLEDLDPYY +KKTFIVLNKGK IFRF+AT ALY+L+PF+PLR+I+IKI
Sbjct: 65   YGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKIAIKI 124

Query: 123  LVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKILARGFCVGEFT 182
            LVHSLFSMLIMCTILTNC+FMTM+NPPDWTKNVEYTFTGIYTFESL+KI+ARGFC+ +FT
Sbjct: 125  LVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFCLEDFT 184

Query: 183  FLRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSV 242
            FLRDPWNWLDF VI FAY+TEFV+LGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSV
Sbjct: 185  FLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSV 244

Query: 243  KKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFR----------NSLENNETLE---SI 289
            KKLSDVMILTVFCLSVFALIGLQLFMGNL++KC +          +S+E N T+    ++
Sbjct: 245  KKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLEEHSIEKNITVNYNGTL 304

Query: 290  MNTLESEEDFR------KYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTS 343
            +N    E D++      +Y Y+LEG  DALLCG S+D+GQCPEGY CVK GRNP+YGYTS
Sbjct: 305  INETVFEFDWKSYIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVKAGRNPNYGYTS 364

Query: 344  FDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAM 403
            FDTFSWAFL+LFRLMTQD+WENLYQ TLRAAGKTYMIFFV+VIFLGSFYLINLILAVVAM
Sbjct: 365  FDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAM 424

Query: 404  AYEEQNQANIEEAKQKELEFQQMLDRLKKEQEEAEAIAAAAAEYTSIRRSRIMGLSESSS 463
            AYEEQNQA +EEA+QKE EFQQM+++LKK+QE A+  A A A   S   S    LS+SSS
Sbjct: 425  AYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHSREPSAAGRLSDSSS 484

Query: 464  ETSKLSSKSAKERRNRRKKKNQKKLSSGEEKGDAEKLSKSESEDSIRRKSFHLGVEGHRR 523
            E SKLSSKSAKERRNRRKK+ QK+ S GEEK D ++  KSESEDSIRRK F   +EG+R 
Sbjct: 485  EASKLSSKSAKERRNRRKKRKQKEQSGGEEK-DEDEFQKSESEDSIRRKGFRFSIEGNRL 543

Query: 524  AHEKRLSTPNQSPLSIRGSLFSARRSSRTSLFSFKGRGRDIGSETEFADDEHSIFGDNES 583
             +EKR S+P+QS LSIRGSLFS RR+SRTSLFSF+GR +D+GSE +FADDEHS F DNES
Sbjct: 544  TYEKRYSSPHQSLLSIRGSLFSPRRNSRTSLFSFRGRAKDVGSENDFADDEHSTFEDNES 603

Query: 584  RRGSLFVPHRPQERRSSNISQASRSPPML---PVNGKMHSAVDCNGVVSLVDGRSALMLP 640
            RR SLFVP R  ERR+SN+SQ SRS  ML   P NGKMHS VDCNGVVSLV G S    P
Sbjct: 604  RRDSLFVPRRHGERRNSNLSQTSRSSRMLAVFPANGKMHSTVDCNGVVSLVGGPSVPTSP 663

Query: 641  NGQLLPEGTTNQIH-KKRRCSSYLLSEDMLNDPNLRQRAMSRASILTNTVEELEESRQKC 699
             GQLLPEGTT +   +KRR SS+ +S D L DP+ RQRAMS ASILTNTVEELEESRQKC
Sbjct: 664  VGQLLPEGTTTETEMRKRRSSSFHVSMDFLEDPSQRQRAMSIASILTNTVEELEESRQKC 723

Query: 700  PPWWYRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTE 759
            PP WY+F++ FLIW+CSPYW+K K  +  +VMDPFVDLAITICIVLNTLFMAMEH+PMT+
Sbjct: 724  PPCWYKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTD 783

Query: 760  EFKNVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADVEG 819
             F NVL +GNLVFTGIF AEM LK+IAMDPY YFQ GWNIFD  IVTLSLVEL LA+VEG
Sbjct: 784  HFNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANVEG 843

Query: 820  LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGK 879
            LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGK
Sbjct: 844  LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGK 903

Query: 880  SYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVYMM 939
            SYK+CVCKI  DC LPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCL V+MM
Sbjct: 904  SYKDCVCKIASDCQLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLTVFMM 963

Query: 940  VMVIGNLVVLNLFLALLLSSFSSDNLTAIEEDPDANNLQIAVTRIKKGINYVKQTLREFI 999
            VMVIGNLVVLNLFLALLLSSFS+DNL A ++D + NNLQIAV R+ KG+ YVK+ + EFI
Sbjct: 964  VMVIGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRMHKGVAYVKRKIYEFI 1023

Query: 1000 LKAFSKKPKISREIRQAEDLNTKKENYISNHTLAEMSKGHNFLKEKDKIS---GFGSSVD 1056
             ++F +K KI  EI+  +DLN KK++ +SNHT AE+ K  ++LK+ +  +   G GSSV+
Sbjct: 1024 QQSFIRKQKILDEIKPLDDLNNKKDSCMSNHT-AEIGKDLDYLKDVNGTTSGIGTGSSVE 1082

Query: 1057 KHLMEDSDGQSFIHNPSLTVTVPIAPGESDLENMNAEELSSDSDSEYSKVRLNRSSSS-E 1115
            K+++++SD  SFI+NPSLTVTVPIA GESD EN+N E+ SS+SD E SK +LN SSSS E
Sbjct: 1083 KYIIDESDYMSFINNPSLTVTVPIAVGESDFENLNTEDFSSESDLEESKEKLNESSSSSE 1142

Query: 1116 CSTVDNPLPGEGEEAEAEPMNSDEPEACFTDGCVRRFSCCQVNIESGKGKIWWNIRKTCY 1175
             STVD   P E E+   EP  + EPEACFT+GCV+RF CCQ+N+E G+GK WWN+R+TC+
Sbjct: 1143 GSTVDIGAPVE-EQPVVEPEETLEPEACFTEGCVQRFKCCQINVEEGRGKQWWNLRRTCF 1201

Query: 1176 KIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILEMLLKWI 1235
            +IVEH+WFE+FIV MILLSSGALAFEDIYI+++KTIK +LEYADK+FTYIFILEMLLKW+
Sbjct: 1202 RIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEMLLKWV 1261

Query: 1236 AYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSRFEG 1295
            AYGY+TYFTNAWCWLDFLIVDVSLV+L AN LGYS+LG IKSLRTLRALRPLRALSRFEG
Sbjct: 1262 AYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEG 1321

Query: 1296 MRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDGSRFPASQVPN 1355
            MRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFY CINTT G RF    V N
Sbjct: 1322 MRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTTTGDRFDIEDVNN 1381

Query: 1356 RSECFALMNVSQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPK 1415
             ++C  L+  ++  RWKN+KVNFDNVG GYLSLLQVATFKGW  IMYAAVDS NV+ QPK
Sbjct: 1382 HTDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPK 1441

Query: 1416 YEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMK 1475
            YE SLYMY+YFV+FIIFGSFFTLNLFIGVIIDNFNQQKKK GGQDIFMTEEQKKYYNAMK
Sbjct: 1442 YEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMK 1501

Query: 1476 KLGSKKPQKPIPRPGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEV 1535
            KLGSKKPQKPIPRPGNK QG +FD VT Q FDISIM+LICLNMVTMMVE + QS+++T +
Sbjct: 1502 KLGSKKPQKPIPRPGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQSEYVTTI 1561

Query: 1536 LYWINVVFIILFTGECVLKLISLRHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSP 1595
            L  IN+VFI+LFTGECVLKLISLRHYYFT+GWNIFDFVVVI+SIVGMFLA+LIE YFVSP
Sbjct: 1562 LSRINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSP 1621

Query: 1596 TLFRVIRLARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNF 1655
            TLFRVIRLARIGRILRL+KGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNF
Sbjct: 1622 TLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNF 1681

Query: 1656 AYVKKEDGINDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSV 1715
            AYVK+E GI+DMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDP KV+PGSSV
Sbjct: 1682 AYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSV 1741

Query: 1716 EGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEVW 1775
            +GDCGNPSVGIF+FVSYIIISFLVVVNMYIAVILENFSVATEES EPLSEDDFEMFYEVW
Sbjct: 1742 KGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVW 1801

Query: 1776 EKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFT 1835
            EKFDPDATQF+EF KLS FAAAL+PPL + +PNK+QLIAMDLPMVSGDRIHCLDILFAFT
Sbjct: 1802 EKFDPDATQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMDLPMVSGDRIHCLDILFAFT 1861

Query: 1836 KRVLGESGEMDSLRSQMEERFMSANPSKVSYEPITTTLKRKQEDVSATVIQRAYRRYRLR 1895
            KRVLGESGEMD+LR QMEERFM++NPSKVSY+PITTTLKRKQE+VSA +IQRAYRR+ L+
Sbjct: 1862 KRVLGESGEMDALRIQMEERFMASNPSKVSYQPITTTLKRKQEEVSAVIIQRAYRRHLLK 1921

Query: 1896 QNVKNISSIYIKDGDRDD-DLLNKKDMAFDNVNENSSPEKTDATSSTTS-PPSYDSVTKP 1953
            + VK  S  Y K+  +   +LL K+DM  D +NENS  EKTD T ST + PPSYD VTKP
Sbjct: 1922 RTVKQASFTYNKNKIKGGANLLIKEDMIIDRINENSITEKTDLTMSTAACPPSYDRVTKP 1981

Query: 1954 DKEKYEQDRTEKEDKGK 1970
              EK+EQ+  +++ KGK
Sbjct: 1982 IVEKHEQEGKDEKAKGK 1998


>gi|126362949 sodium channel, voltage-gated, type III, alpha isoform 1
            [Homo sapiens]
          Length = 2000

 Score = 3023 bits (7837), Expect = 0.0
 Identities = 1526/2005 (76%), Positives = 1732/2005 (86%), Gaps = 37/2005 (1%)

Query: 2    AMLPPPGPQSFVHFTKQSLALIEQRIAERKSKEPKEEKKDDDEEAPKPSSDLEAGKQLPF 61
            A+L PPGP+SF  FT++SLA IE+R AE K+K+PK+E+ +DDE  PKP+SDLEAGK LPF
Sbjct: 4    ALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKNLPF 63

Query: 62   IYGDIPPGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRISIK 121
            IYGDIPP MVSEPLEDLDPYY +KKTFIV+NKGK IFRF+AT ALY+L+P +P+R+I+IK
Sbjct: 64   IYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIAIK 123

Query: 122  ILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKILARGFCVGEF 181
            ILVHSLFSMLIMCTILTNC+FMT++NPPDWTKNVEYTFTGIYTFESL+KILARGFC+ +F
Sbjct: 124  ILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDF 183

Query: 182  TFLRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQS 241
            TFLRDPWNWLDF VIV AY+TEFV+LGNVSALRTFRVLRALKTISVIPGLKTIVGALIQS
Sbjct: 184  TFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQS 243

Query: 242  VKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKC-----------------FRNSLENNE 284
            VKKLSDVMILTVFCLSVFALIGLQLFMGNL++KC                 F  ++++N 
Sbjct: 244  VKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSNG 303

Query: 285  TLESIMNTLESEEDF---RKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGY 341
            T  ++  +  + +D+     +FY L+G KD LLCG  +D+GQCPEGY CVK GRNP+YGY
Sbjct: 304  TFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPNYGY 363

Query: 342  TSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVV 401
            TSFDTFSWAFL+LFRLMTQDYWENLYQ TLRAAGKTYMIFFV+VIFLGSFYL+NLILAVV
Sbjct: 364  TSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVV 423

Query: 402  AMAYEEQNQANIEEAKQKELEFQQMLDRLKKEQEEAEAIAAAAAEYTSIRRSRIMG-LSE 460
            AMAYEEQNQA +EEA+QKE EFQQML++LKK+QEEA+A+AAA+A          +G L E
Sbjct: 424  AMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGLGELLE 483

Query: 461  SSSETSKLSSKSAKERRNRRKKKNQKKLSSGEEKGDAEKLSKSESEDSIRRKSFHLGVEG 520
            SSSE SKLSSKSAKE RNRRKK+ Q++   G  KG+ +   KSESEDS++R SF   ++G
Sbjct: 484  SSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFLFSMDG 543

Query: 521  HRRAHEKRLSTPNQSPLSIRGSLFSARRSSRTSLFSFKGRGRDIGSETEFADDEHSIFGD 580
            +R   +K+  +P+QS LSIRGSLFS RR+S+TS+FSF+GR +D+GSE +FADDEHS F D
Sbjct: 544  NRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEHSTFED 603

Query: 581  NESRRGSLFVPHRPQERRSSNISQASRSP---PMLPVNGKMHSAVDCNGVVSLVDGRSAL 637
            +ESRR SLFVPHR  ERR+SN+SQAS S    P LP NGKMHS VDCNGVVSLV G SAL
Sbjct: 604  SESRRDSLFVPHRHGERRNSNVSQASMSSRMVPGLPANGKMHSTVDCNGVVSLVGGPSAL 663

Query: 638  MLPNGQLLPEGTTNQIH-KKRRCSSYLLSEDMLNDPNLRQRAMSRASILTNTVEELEESR 696
              P GQL PEGTT +   +KRR SSY +S +ML D + RQRA+S ASILTNT+EELEESR
Sbjct: 664  TSPTGQLPPEGTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIASILTNTMEELEESR 723

Query: 697  QKCPPWWYRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHP 756
            QKCPP WYRFA+ FLIW+C   W+K K  +  IVMDPFVDLAITICIVLNTLFMAMEH+P
Sbjct: 724  QKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYP 783

Query: 757  MTEEFKNVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLAD 816
            MTE+F +VL +GNLVFTGIF AEMVLK+IAMDPY YFQ GWNIFD +IV+LSL+EL L++
Sbjct: 784  MTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLSN 843

Query: 817  VEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQL 876
            VEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQL
Sbjct: 844  VEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQL 903

Query: 877  FGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIV 936
            FGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQ MCLIV
Sbjct: 904  FGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLIV 963

Query: 937  YMMVMVIGNLVVLNLFLALLLSSFSSDNLTAIEEDPDANNLQIAVTRIKKGINYVKQTLR 996
            +M+VMVIGNLVVLNLFLALLLSSFSSDNL A ++D + NNLQIAV R++KGI+YVK  +R
Sbjct: 964  FMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYVKNKMR 1023

Query: 997  EFILKAFSKKPKISREIRQAEDLNTKKENYISNHTLAEMSKGHNFLKEKDKIS---GFGS 1053
            E   KAF +KPK+  EI +      K ++ +SN+T  E+SK  N+L++ +  +   G GS
Sbjct: 1024 ECFQKAFFRKPKVI-EIHEGN----KIDSCMSNNTGIEISKELNYLRDGNGTTSGVGTGS 1078

Query: 1054 SVDKHLMEDSDGQSFIHNPSLTVTVPIAPGESDLENMNAEELSSDSDSEYSKVRLNRSSS 1113
            SV+K++++++D  SFI+NPSLTVTVPIA GESD EN+N EE SS+S+ E SK +LN +SS
Sbjct: 1079 SVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEESKEKLNATSS 1138

Query: 1114 SECSTVDNPLPGEGEEAEAEPMNSDEPEACFTDGCVRRFSCCQVNIESGKGKIWWNIRKT 1173
            SE STVD  LP EGE+AE EP    +PEACFT+GC+++F  CQV+ E GKGKIWWN+RKT
Sbjct: 1139 SEGSTVDVVLPREGEQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKT 1198

Query: 1174 CYKIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILEMLLK 1233
            CY IVEH+WFE+FIV MILLSSGALAFEDIYIE++KTIK +LEYADK+FTYIFILEMLLK
Sbjct: 1199 CYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLK 1258

Query: 1234 WIAYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSRF 1293
            W+AYG++TYFTNAWCWLDFLIVDVSLV+LVAN LGYS+LG IKSLRTLRALRPLRALSRF
Sbjct: 1259 WVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRF 1318

Query: 1294 EGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDGSRFPASQV 1353
            EGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFY C+N T G+ F  S V
Sbjct: 1319 EGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNMFDISDV 1378

Query: 1354 PNRSECFALMNVSQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQ 1413
             N S+C AL    +  RWKN+KVNFDNVG GYL+LLQVATFKGW  IMYAAVDS +V  Q
Sbjct: 1379 NNLSDCQAL---GKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQ 1435

Query: 1414 PKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNA 1473
            P YE +LYMY+YFV+FIIFGSFFTLNLFIGVIIDNFNQQKKK GGQDIFMTEEQKKYYNA
Sbjct: 1436 PVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNA 1495

Query: 1474 MKKLGSKKPQKPIPRPGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMT 1533
            MKKLGSKKPQKPIPRP NK QG +FD VT Q FDISIM+LICLNMVTMMVE + Q ++MT
Sbjct: 1496 MKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMT 1555

Query: 1534 EVLYWINVVFIILFTGECVLKLISLRHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFV 1593
             VL  IN+VFI+LFTGE VLKL+SLRHYYFT+GWNIFDFVVVI+SIVGMFLA++IE YFV
Sbjct: 1556 LVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFV 1615

Query: 1594 SPTLFRVIRLARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMS 1653
            SPTLFRVIRLARIGRILRL+KGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMS
Sbjct: 1616 SPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMS 1675

Query: 1654 NFAYVKKEDGINDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGS 1713
            NFAYVKKE GI+DMFNFETFGNSMICLFQITTSAGWDGLLAPILNS PPDCDP  +HPGS
Sbjct: 1676 NFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGS 1735

Query: 1714 SVEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYE 1773
            SV+GDCGNPSVGIF+FVSYIIISFLVVVNMYIAVILENFSVATEES EPLSEDDFEMFYE
Sbjct: 1736 SVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYE 1795

Query: 1774 VWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFA 1833
            VWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFA
Sbjct: 1796 VWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFA 1855

Query: 1834 FTKRVLGESGEMDSLRSQMEERFMSANPSKVSYEPITTTLKRKQEDVSATVIQRAYRRYR 1893
            FTKRVLGESGEMD+LR QME+RFM++NPSKVSYEPITTTLKRKQE+VSA +IQR +R Y 
Sbjct: 1856 FTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQRNFRCYL 1915

Query: 1894 LRQNVKNISSIYIKDGDRDD-DLLNKKDMAFDNVNENSSPEKTDATSSTTSPPSYDSVTK 1952
            L+Q +KNISS Y K+  +   DL  K+DM  D +N NS+PEKTD +SSTTSPPSYDSVTK
Sbjct: 1916 LKQRLKNISSNYNKEAIKGRIDLPIKQDMIIDKLNGNSTPEKTDGSSSTTSPPSYDSVTK 1975

Query: 1953 PDKEKYEQDRTEKEDKGKDSKESKK 1977
            PDKEK+E+D+ EKE KGK+ +E++K
Sbjct: 1976 PDKEKFEKDKPEKESKGKEVRENQK 2000


>gi|126362955 sodium channel, voltage-gated, type III, alpha isoform 3
            [Homo sapiens]
          Length = 1951

 Score = 2943 bits (7629), Expect = 0.0
 Identities = 1492/2002 (74%), Positives = 1697/2002 (84%), Gaps = 80/2002 (3%)

Query: 2    AMLPPPGPQSFVHFTKQSLALIEQRIAERKSKEPKEEKKDDDEEAPKPSSDLEAGKQLPF 61
            A+L PPGP+SF  FT++SLA IE+R AE K+K+PK+E+ +DDE  PKP+SDLEAGK LPF
Sbjct: 4    ALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKNLPF 63

Query: 62   IYGDIPPGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRISIK 121
            IYGDIPP MVSEPLEDLDPYY +KKTFIV+NKGK IFRF+AT ALY+L+P +P+R+I+IK
Sbjct: 64   IYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIAIK 123

Query: 122  ILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKILARGFCVGEF 181
            ILVHSLFSMLIMCTILTNC+FMT++NPPDWTKNVEYTFTGIYTFESL+KILARGFC+ +F
Sbjct: 124  ILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDF 183

Query: 182  TFLRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQS 241
            TFLRDPWNWLDF VIV AY+TEFV+LGNVSALRTFRVLRALKTISVIPGLKTIVGALIQS
Sbjct: 184  TFLRDPWNWLDFSVIVMAYVTEFVSLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQS 243

Query: 242  VKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKC-----------------FRNSLENNE 284
            VKKLSDVMILTVFCLSVFALIGLQLFMGNL++KC                 F  ++++N 
Sbjct: 244  VKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSNG 303

Query: 285  TLESIMNTLESEEDF---RKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGY 341
            T  ++  +  + +D+     +FY L+G KD LLCG  +D+GQCPEGY CVK GRNP+YGY
Sbjct: 304  TFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPNYGY 363

Query: 342  TSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVV 401
            TSFDTFSWAFL+LFRLMTQDYWENLYQ TLRAAGKTYMIFFV+VIFLGSFYL+NLILAVV
Sbjct: 364  TSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVV 423

Query: 402  AMAYEEQNQANIEEAKQKELEFQQMLDRLKKEQEEAEAIAAAAAEYTSIRRSRIMG-LSE 460
            AMAYEEQNQA +EEA+QKE EFQQML++LKK+QEEA+A+AAA+A          +G L E
Sbjct: 424  AMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGLGELLE 483

Query: 461  SSSETSKLSSKSAKERRNRRKKKNQKKLSSGEEKGDAEKLSKSESEDSIRRKSFHLGVEG 520
            SSSE SKLSSKSAKE RNRRKK+ Q++   G  KG+ +   KSESEDS++R SF   ++G
Sbjct: 484  SSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFLFSMDG 543

Query: 521  HRRAHEKRLSTPNQSPLSIRGSLFSARRSSRTSLFSFKGRGRDIGSETEFADDEHSIFGD 580
            +R   +K+  +P+QS LSIRGSLFS RR+S+TS+FSF+GR +D+GSE +FADDEHS F D
Sbjct: 544  NRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEHSTFED 603

Query: 581  NESRRGSLFVPHRPQERRSSNISQASRSPPMLPVNGKMHSAVDCNGVVSLVDGRSALMLP 640
            +ESRR SLFVPHR  ERR+SN                                       
Sbjct: 604  SESRRDSLFVPHRHGERRNSN--------------------------------------- 624

Query: 641  NGQLLPEGTTNQIH-KKRRCSSYLLSEDMLNDPNLRQRAMSRASILTNTVEELEESRQKC 699
                   GTT +   +KRR SSY +S +ML D + RQRA+S ASILTNT+EELEESRQKC
Sbjct: 625  -------GTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIASILTNTMEELEESRQKC 677

Query: 700  PPWWYRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTE 759
            PP WYRFA+ FLIW+C   W+K K  +  IVMDPFVDLAITICIVLNTLFMAMEH+PMTE
Sbjct: 678  PPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTE 737

Query: 760  EFKNVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADVEG 819
            +F +VL +GNLVFTGIF AEMVLK+IAMDPY YFQ GWNIFD +IV+LSL+EL L++VEG
Sbjct: 738  QFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEG 797

Query: 820  LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGK 879
            LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGK
Sbjct: 798  LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGK 857

Query: 880  SYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVYMM 939
            SYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQ MCLIV+M+
Sbjct: 858  SYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLIVFML 917

Query: 940  VMVIGNLVVLNLFLALLLSSFSSDNLTAIEEDPDANNLQIAVTRIKKGINYVKQTLREFI 999
            VMVIGNLVVLNLFLALLLSSFSSDNL A ++D + NNLQIAV R++KGI+YVK  +RE  
Sbjct: 918  VMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYVKNKMRECF 977

Query: 1000 LKAFSKKPKISREIRQAEDLNTKKENYISNHTLAEMSKGHNFLKEKDKIS---GFGSSVD 1056
             KAF +KPK+  EI +      K ++ +SN+T  E+SK  N+L++ +  +   G GSSV+
Sbjct: 978  QKAFFRKPKVI-EIHEGN----KIDSCMSNNTGIEISKELNYLRDGNGTTSGVGTGSSVE 1032

Query: 1057 KHLMEDSDGQSFIHNPSLTVTVPIAPGESDLENMNAEELSSDSDSEYSKVRLNRSSSSEC 1116
            K++++++D  SFI+NPSLTVTVPIA GESD EN+N EE SS+S+ E SK +LN +SSSE 
Sbjct: 1033 KYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEESKEKLNATSSSEG 1092

Query: 1117 STVDNPLPGEGEEAEAEPMNSDEPEACFTDGCVRRFSCCQVNIESGKGKIWWNIRKTCYK 1176
            STVD  LP EGE+AE EP    +PEACFT+GC+++F  CQV+ E GKGKIWWN+RKTCY 
Sbjct: 1093 STVDVVLPREGEQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCYS 1152

Query: 1177 IVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILEMLLKWIA 1236
            IVEH+WFE+FIV MILLSSGALAFEDIYIE++KTIK +LEYADK+FTYIFILEMLLKW+A
Sbjct: 1153 IVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVA 1212

Query: 1237 YGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSRFEGM 1296
            YG++TYFTNAWCWLDFLIVDVSLV+LVAN LGYS+LG IKSLRTLRALRPLRALSRFEGM
Sbjct: 1213 YGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEGM 1272

Query: 1297 RVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDGSRFPASQVPNR 1356
            RVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFY C+N T G+ F  S V N 
Sbjct: 1273 RVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNMFDISDVNNL 1332

Query: 1357 SECFALMNVSQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKY 1416
            S+C AL    +  RWKN+KVNFDNVG GYL+LLQVATFKGW  IMYAAVDS +V  QP Y
Sbjct: 1333 SDCQAL---GKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVY 1389

Query: 1417 EYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK 1476
            E +LYMY+YFV+FIIFGSFFTLNLFIGVIIDNFNQQKKK GGQDIFMTEEQKKYYNAMKK
Sbjct: 1390 EENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKK 1449

Query: 1477 LGSKKPQKPIPRPGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVL 1536
            LGSKKPQKPIPRP NK QG +FD VT Q FDISIM+LICLNMVTMMVE + Q ++MT VL
Sbjct: 1450 LGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVL 1509

Query: 1537 YWINVVFIILFTGECVLKLISLRHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPT 1596
              IN+VFI+LFTGE VLKL+SLRHYYFT+GWNIFDFVVVI+SIVGMFLA++IE YFVSPT
Sbjct: 1510 SRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPT 1569

Query: 1597 LFRVIRLARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA 1656
            LFRVIRLARIGRILRL+KGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA
Sbjct: 1570 LFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA 1629

Query: 1657 YVKKEDGINDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVE 1716
            YVKKE GI+DMFNFETFGNSMICLFQITTSAGWDGLLAPILNS PPDCDP  +HPGSSV+
Sbjct: 1630 YVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVK 1689

Query: 1717 GDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWE 1776
            GDCGNPSVGIF+FVSYIIISFLVVVNMYIAVILENFSVATEES EPLSEDDFEMFYEVWE
Sbjct: 1690 GDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWE 1749

Query: 1777 KFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTK 1836
            KFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTK
Sbjct: 1750 KFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTK 1809

Query: 1837 RVLGESGEMDSLRSQMEERFMSANPSKVSYEPITTTLKRKQEDVSATVIQRAYRRYRLRQ 1896
            RVLGESGEMD+LR QME+RFM++NPSKVSYEPITTTLKRKQE+VSA +IQR +R Y L+Q
Sbjct: 1810 RVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQRNFRCYLLKQ 1869

Query: 1897 NVKNISSIYIKDGDRDD-DLLNKKDMAFDNVNENSSPEKTDATSSTTSPPSYDSVTKPDK 1955
             +KNISS Y K+  +   DL  K+DM  D +N NS+PEKTD +SSTTSPPSYDSVTKPDK
Sbjct: 1870 RLKNISSNYNKEAIKGRIDLPIKQDMIIDKLNGNSTPEKTDGSSSTTSPPSYDSVTKPDK 1929

Query: 1956 EKYEQDRTEKEDKGKDSKESKK 1977
            EK+E+D+ EKE KGK+ +E++K
Sbjct: 1930 EKFEKDKPEKESKGKEVRENQK 1951


>gi|126362947 sodium channel, voltage-gated, type III, alpha isoform 2
            [Homo sapiens]
          Length = 1951

 Score = 2943 bits (7629), Expect = 0.0
 Identities = 1492/2002 (74%), Positives = 1697/2002 (84%), Gaps = 80/2002 (3%)

Query: 2    AMLPPPGPQSFVHFTKQSLALIEQRIAERKSKEPKEEKKDDDEEAPKPSSDLEAGKQLPF 61
            A+L PPGP+SF  FT++SLA IE+R AE K+K+PK+E+ +DDE  PKP+SDLEAGK LPF
Sbjct: 4    ALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKNLPF 63

Query: 62   IYGDIPPGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRISIK 121
            IYGDIPP MVSEPLEDLDPYY +KKTFIV+NKGK IFRF+AT ALY+L+P +P+R+I+IK
Sbjct: 64   IYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIAIK 123

Query: 122  ILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKILARGFCVGEF 181
            ILVHSLFSMLIMCTILTNC+FMT++NPPDWTKNVEYTFTGIYTFESL+KILARGFC+ +F
Sbjct: 124  ILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDF 183

Query: 182  TFLRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQS 241
            TFLRDPWNWLDF VIV AY+TEFV+LGNVSALRTFRVLRALKTISVIPGLKTIVGALIQS
Sbjct: 184  TFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQS 243

Query: 242  VKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKC-----------------FRNSLENNE 284
            VKKLSDVMILTVFCLSVFALIGLQLFMGNL++KC                 F  ++++N 
Sbjct: 244  VKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSNG 303

Query: 285  TLESIMNTLESEEDF---RKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGY 341
            T  ++  +  + +D+     +FY L+G KD LLCG  +D+GQCPEGY CVK GRNP+YGY
Sbjct: 304  TFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPNYGY 363

Query: 342  TSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVV 401
            TSFDTFSWAFL+LFRLMTQDYWENLYQ TLRAAGKTYMIFFV+VIFLGSFYL+NLILAVV
Sbjct: 364  TSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVV 423

Query: 402  AMAYEEQNQANIEEAKQKELEFQQMLDRLKKEQEEAEAIAAAAAEYTSIRRSRIMG-LSE 460
            AMAYEEQNQA +EEA+QKE EFQQML++LKK+QEEA+A+AAA+A          +G L E
Sbjct: 424  AMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGLGELLE 483

Query: 461  SSSETSKLSSKSAKERRNRRKKKNQKKLSSGEEKGDAEKLSKSESEDSIRRKSFHLGVEG 520
            SSSE SKLSSKSAKE RNRRKK+ Q++   G  KG+ +   KSESEDS++R SF   ++G
Sbjct: 484  SSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFLFSMDG 543

Query: 521  HRRAHEKRLSTPNQSPLSIRGSLFSARRSSRTSLFSFKGRGRDIGSETEFADDEHSIFGD 580
            +R   +K+  +P+QS LSIRGSLFS RR+S+TS+FSF+GR +D+GSE +FADDEHS F D
Sbjct: 544  NRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEHSTFED 603

Query: 581  NESRRGSLFVPHRPQERRSSNISQASRSPPMLPVNGKMHSAVDCNGVVSLVDGRSALMLP 640
            +ESRR SLFVPHR  ERR+SN                                       
Sbjct: 604  SESRRDSLFVPHRHGERRNSN--------------------------------------- 624

Query: 641  NGQLLPEGTTNQIH-KKRRCSSYLLSEDMLNDPNLRQRAMSRASILTNTVEELEESRQKC 699
                   GTT +   +KRR SSY +S +ML D + RQRA+S ASILTNT+EELEESRQKC
Sbjct: 625  -------GTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIASILTNTMEELEESRQKC 677

Query: 700  PPWWYRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTE 759
            PP WYRFA+ FLIW+C   W+K K  +  IVMDPFVDLAITICIVLNTLFMAMEH+PMTE
Sbjct: 678  PPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTE 737

Query: 760  EFKNVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADVEG 819
            +F +VL +GNLVFTGIF AEMVLK+IAMDPY YFQ GWNIFD +IV+LSL+EL L++VEG
Sbjct: 738  QFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEG 797

Query: 820  LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGK 879
            LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGK
Sbjct: 798  LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGK 857

Query: 880  SYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVYMM 939
            SYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQ MCLIV+M+
Sbjct: 858  SYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLIVFML 917

Query: 940  VMVIGNLVVLNLFLALLLSSFSSDNLTAIEEDPDANNLQIAVTRIKKGINYVKQTLREFI 999
            VMVIGNLVVLNLFLALLLSSFSSDNL A ++D + NNLQIAV R++KGI+YVK  +RE  
Sbjct: 918  VMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYVKNKMRECF 977

Query: 1000 LKAFSKKPKISREIRQAEDLNTKKENYISNHTLAEMSKGHNFLKEKDKIS---GFGSSVD 1056
             KAF +KPK+  EI +      K ++ +SN+T  E+SK  N+L++ +  +   G GSSV+
Sbjct: 978  QKAFFRKPKVI-EIHEGN----KIDSCMSNNTGIEISKELNYLRDGNGTTSGVGTGSSVE 1032

Query: 1057 KHLMEDSDGQSFIHNPSLTVTVPIAPGESDLENMNAEELSSDSDSEYSKVRLNRSSSSEC 1116
            K++++++D  SFI+NPSLTVTVPIA GESD EN+N EE SS+S+ E SK +LN +SSSE 
Sbjct: 1033 KYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEESKEKLNATSSSEG 1092

Query: 1117 STVDNPLPGEGEEAEAEPMNSDEPEACFTDGCVRRFSCCQVNIESGKGKIWWNIRKTCYK 1176
            STVD  LP EGE+AE EP    +PEACFT+GC+++F  CQV+ E GKGKIWWN+RKTCY 
Sbjct: 1093 STVDVVLPREGEQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCYS 1152

Query: 1177 IVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILEMLLKWIA 1236
            IVEH+WFE+FIV MILLSSGALAFEDIYIE++KTIK +LEYADK+FTYIFILEMLLKW+A
Sbjct: 1153 IVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVA 1212

Query: 1237 YGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSRFEGM 1296
            YG++TYFTNAWCWLDFLIVDVSLV+LVAN LGYS+LG IKSLRTLRALRPLRALSRFEGM
Sbjct: 1213 YGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEGM 1272

Query: 1297 RVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDGSRFPASQVPNR 1356
            RVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFY C+N T G+ F  S V N 
Sbjct: 1273 RVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNMFDISDVNNL 1332

Query: 1357 SECFALMNVSQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKY 1416
            S+C AL    +  RWKN+KVNFDNVG GYL+LLQVATFKGW  IMYAAVDS +V  QP Y
Sbjct: 1333 SDCQAL---GKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVY 1389

Query: 1417 EYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK 1476
            E +LYMY+YFV+FIIFGSFFTLNLFIGVIIDNFNQQKKK GGQDIFMTEEQKKYYNAMKK
Sbjct: 1390 EENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKK 1449

Query: 1477 LGSKKPQKPIPRPGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVL 1536
            LGSKKPQKPIPRP NK QG +FD VT Q FDISIM+LICLNMVTMMVE + Q ++MT VL
Sbjct: 1450 LGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVL 1509

Query: 1537 YWINVVFIILFTGECVLKLISLRHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPT 1596
              IN+VFI+LFTGE VLKL+SLRHYYFT+GWNIFDFVVVI+SIVGMFLA++IE YFVSPT
Sbjct: 1510 SRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPT 1569

Query: 1597 LFRVIRLARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA 1656
            LFRVIRLARIGRILRL+KGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA
Sbjct: 1570 LFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA 1629

Query: 1657 YVKKEDGINDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVE 1716
            YVKKE GI+DMFNFETFGNSMICLFQITTSAGWDGLLAPILNS PPDCDP  +HPGSSV+
Sbjct: 1630 YVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVK 1689

Query: 1717 GDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWE 1776
            GDCGNPSVGIF+FVSYIIISFLVVVNMYIAVILENFSVATEES EPLSEDDFEMFYEVWE
Sbjct: 1690 GDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWE 1749

Query: 1777 KFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTK 1836
            KFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTK
Sbjct: 1750 KFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTK 1809

Query: 1837 RVLGESGEMDSLRSQMEERFMSANPSKVSYEPITTTLKRKQEDVSATVIQRAYRRYRLRQ 1896
            RVLGESGEMD+LR QME+RFM++NPSKVSYEPITTTLKRKQE+VSA +IQR +R Y L+Q
Sbjct: 1810 RVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQRNFRCYLLKQ 1869

Query: 1897 NVKNISSIYIKDGDRDD-DLLNKKDMAFDNVNENSSPEKTDATSSTTSPPSYDSVTKPDK 1955
             +KNISS Y K+  +   DL  K+DM  D +N NS+PEKTD +SSTTSPPSYDSVTKPDK
Sbjct: 1870 RLKNISSNYNKEAIKGRIDLPIKQDMIIDKLNGNSTPEKTDGSSSTTSPPSYDSVTKPDK 1929

Query: 1956 EKYEQDRTEKEDKGKDSKESKK 1977
            EK+E+D+ EKE KGK+ +E++K
Sbjct: 1930 EKFEKDKPEKESKGKEVRENQK 1951


>gi|7657544 sodium channel, voltage gated, type VIII, alpha [Homo
            sapiens]
          Length = 1980

 Score = 2752 bits (7134), Expect = 0.0
 Identities = 1424/2005 (71%), Positives = 1640/2005 (81%), Gaps = 61/2005 (3%)

Query: 3    MLPPPGPQSFVHFTKQSLALIEQRIAERKSKEPKE----EKKDDDEEAPKPSSDLEAGKQ 58
            +L PPGP SF  FT +SLA IE+RIAE K K+P +     ++DD++  PKP+SDLEAGK 
Sbjct: 5    LLAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNSDLEAGKS 64

Query: 59   LPFIYGDIPPGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRI 118
            LPFIYGDIP G+V+ PLED DPYY  +KTF+VLN+GKT+FRF+ATPALY+LSPF+ +RRI
Sbjct: 65   LPFIYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNLIRRI 124

Query: 119  SIKILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKILARGFCV 178
            +IKIL+HS+FSM+IMCTILTNC+FMT +NPPDW+KNVEYTFTGIYTFESLVKI+ARGFC+
Sbjct: 125  AIKILIHSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIARGFCI 184

Query: 179  GEFTFLRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGAL 238
              FTFLRDPWNWLDF VI+ AY+TEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGAL
Sbjct: 185  DGFTFLRDPWNWLDFSVIMMAYITEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGAL 244

Query: 239  IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNET-LESIMNTLESEE 297
            IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNL++KC    +  NE+ LE+     + EE
Sbjct: 245  IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNESYLENGTKGFDWEE 304

Query: 298  --DFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLALF 355
              + +  FY + G  + LLCG S+D+GQCPEGY C+K GRNP+YGYTSFDTFSWAFLALF
Sbjct: 305  YINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGYTSFDTFSWAFLALF 364

Query: 356  RLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANIEE 415
            RLMTQDYWENLYQ TLRAAGKTYMIFFV+VIF+GSFYL+NLILAVVAMAYEEQNQA +EE
Sbjct: 365  RLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQATLEE 424

Query: 416  AKQKELEFQQMLDRLKKEQEEAEAIAAAAAEYTSIRRSRIM-------GLSESSSETSKL 468
            A+QKE EF+ ML++LKK+QEEA+A A A +  T +    I        G   SSSE SKL
Sbjct: 425  AEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGT-VSEDAIEEEGEEGGGSPRSSSEISKL 483

Query: 469  SSKSAKERRNRRKKKNQKKLSSGEEKGDAEKLSKSESEDSIRRKSFHLGVEGHRRAHEKR 528
            SSKSAKERRNRRKK+ QK+LS GEEKGD EK+ KSESED +RRK+F L      R    +
Sbjct: 484  SSKSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESEDGMRRKAFRLPDNRIGR----K 539

Query: 529  LSTPNQSPLSIRGSLFSARRSSRTSLFSFKGRGR--DIGSETEFADDEHSIFGDNESRRG 586
             S  NQS LSI GS F +R +S++S+FSF+G GR  D GSE EFADDEHS   ++E RR 
Sbjct: 540  FSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPGSENEFADDEHSTVEESEGRRD 599

Query: 587  SLFVPHRPQERRSS-----NISQASRSP---PMLPVNGKMHSAVDCNGVVSLVDGRSALM 638
            SLF+P R +ERRSS       SQ SRS    P L  + K +S VDCNGVVSL+ G  + +
Sbjct: 600  SLFIPIRARERRSSYSGYSGYSQGSRSSRIFPSLRRSVKRNSTVDCNGVVSLIGGPGSHI 659

Query: 639  LPNGQLLPEGTTNQIHKKRRCSSYLLSEDMLNDPNLRQRAMSRASILTNT-VEELEESRQ 697
               G+LLPE TT    KK+   S L+S D L     + R  S  S++TNT VEELEES++
Sbjct: 660  --GGRLLPEATTEVEIKKKGPGSLLVSMDQLASYGRKDRINSIMSVVTNTLVEELEESQR 717

Query: 698  KCPPWWYRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPM 757
            KCPP WY+FA+ FLIW C PYWIK K+ +  IVMDPFVDLAITICIVLNTLFMAMEHHPM
Sbjct: 718  KCPPCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPM 777

Query: 758  TEEFKNVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADV 817
            T +F++VLA+GNLVFTGIF AEM LKLIAMDPY YFQ GWNIFD  IV+LSL+EL LADV
Sbjct: 778  TPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLMELSLADV 837

Query: 818  EGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 877
            EGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF
Sbjct: 838  EGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 897

Query: 878  GKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVY 937
            GKSYKECVCKIN DC LPRWHM+DFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIV+
Sbjct: 898  GKSYKECVCKINQDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVF 957

Query: 938  MMVMVIGNLVVLNLFLALLLSSFSSDNLTAIEEDPDANNLQIAVTRIKKGINYVKQTLRE 997
            MMVMVIGNLVVLNLFLALLLSSFS+DNL A ++D + NNLQI+V RIKKG+ + K  +  
Sbjct: 958  MMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNLQISVIRIKKGVAWTKLKVHA 1017

Query: 998  FILKAFSKKPKISREIRQAEDLNTKKENYISNHTLAEMSKGHNFLKEKD-KISGFGSSVD 1056
            F+   F  K + + E++  ++L  KK N I+NHT A++ +  +F K  +   SG GSSV+
Sbjct: 1018 FMQAHF--KQREADEVKPLDELYEKKANCIANHTGADIHRNGDFQKNGNGTTSGIGSSVE 1075

Query: 1057 KHLMEDSDGQSFIHNPSLTVTVPIAPGESDLENMNAEELSSDSDSEYSKVRLNRSSSSEC 1116
            K+++ D D  SFI+NP+LTV VPIA GESD EN+N E++SS+SD E SK +L+ +SSSE 
Sbjct: 1076 KYII-DEDHMSFINNPNLTVRVPIAVGESDFENLNTEDVSSESDPEGSKDKLDDTSSSEG 1134

Query: 1117 STVDNPLPGEGEEAEAE-PMNSDEPEACFTDGCVRRFSCCQVNIESGKGKIWWNIRKTCY 1175
            ST+D  +  E EE   E P    +P+ACFT+GCV+RF CCQVNIE G GK WW +RKTC+
Sbjct: 1135 STID--IKPEVEEVPVEQPEEYLDPDACFTEGCVQRFKCCQVNIEEGLGKSWWILRKTCF 1192

Query: 1176 KIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILEMLLKWI 1235
             IVEH+WFE+FI+ MILLSSGALAFEDIYIE++KTI+ ILEYADK+FTYIFILEMLLKW 
Sbjct: 1193 LIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILEMLLKWT 1252

Query: 1236 AYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSRFEG 1295
            AYG+  +FTNAWCWLDFLIV VSLV+L+AN LGYS+LG IKSLRTLRALRPLRALSRFEG
Sbjct: 1253 AYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLRALSRFEG 1312

Query: 1296 MRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDGSRFPASQVPN 1355
            MRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK++ C N T   RF    V N
Sbjct: 1313 MRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNETSEIRFEIEDVNN 1372

Query: 1356 RSECFALMNVSQN-VRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQP 1414
            ++EC  LM  +   +RWKN+K+NFDNVG GYL+LLQVATFKGW  IMYAAVDS   D+QP
Sbjct: 1373 KTECEKLMEGNNTEIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQP 1432

Query: 1415 KYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAM 1474
            KYE ++YMYIYFV+FIIFGSFFTLNLFIGVIIDNFNQQKKK GGQDIFMTEEQKKYYNAM
Sbjct: 1433 KYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAM 1492

Query: 1475 KKLGSKKPQKPIPRPGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTE 1534
            KKLGSKKPQKPIPRP NKIQG +FD VT QAFDI IM+LICLNMVTMMVE + QS+ M  
Sbjct: 1493 KKLGSKKPQKPIPRPLNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVETDTQSKQMEN 1552

Query: 1535 VLYWINVVFIILFTGECVLKLISLRHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVS 1594
            +LYWIN+VF+I FT ECVLK+ +LRHYYFT+GWNIFDFVVVI+SIVGMFLAD+IE YFVS
Sbjct: 1553 ILYWINLVFVIFFTCECVLKMFALRHYYFTIGWNIFDFVVVILSIVGMFLADIIEKYFVS 1612

Query: 1595 PTLFRVIRLARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSN 1654
            PTLFRVIRLARIGRILRL+KGAKGIRTLLFALMMSLPALFNIGLLLFLVMFI++IFGMSN
Sbjct: 1613 PTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSN 1672

Query: 1655 FAYVKKEDGINDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSS 1714
            FAYVK E GI+DMFNFETFGNSMICLFQITTSAGWDGLL PILN +PPDC   K HPGS 
Sbjct: 1673 FAYVKHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILN-RPPDCSLDKEHPGSG 1731

Query: 1715 VEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEV 1774
             +GDCGNPSVGIF+FVSYIIISFL+VVNMYIA+ILENFSVATEES +PLSEDDFE FYE+
Sbjct: 1732 FKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEI 1791

Query: 1775 WEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAF 1834
            WEKFDPDATQFIE+ KL+DFA AL+ PL + KPN ++LIAMDLPMVSGDRIHCLDILFAF
Sbjct: 1792 WEKFDPDATQFIEYCKLADFADALEHPLRVPKPNTIELIAMDLPMVSGDRIHCLDILFAF 1851

Query: 1835 TKRVLGESGEMDSLRSQMEERFMSANPSKVSYEPITTTLKRKQEDVSATVIQRAYRRYRL 1894
            TKRVLG+SGE+D LR QMEERF+++NPSKVSYEPITTTL+RKQE+VSA V+QRAYR +  
Sbjct: 1852 TKRVLGDSGELDILRQQMEERFVASNPSKVSYEPITTTLRRKQEEVSAVVLQRAYRGHLA 1911

Query: 1895 RQNVKNISSIYIKDGDRDDDLLNKKDMAFDNVNENSSPEKTDATSSTTSPPSYDSVTKPD 1954
            R+                   + KK  +    N  +  EK ++T ST S PSYDSVTKP+
Sbjct: 1912 RRG-----------------FICKKTTSNKLENGGTHREKKESTPSTASLPSYDSVTKPE 1954

Query: 1955 KEKY---EQDRTEKEDKGKDSKESK 1976
            KEK    E+ R E+  + K+ +ESK
Sbjct: 1955 KEKQQRAEEGRRERAKRQKEVRESK 1979


>gi|237512982 voltage-gated sodium channel type V alpha isoform f
            [Homo sapiens]
          Length = 1962

 Score = 2366 bits (6132), Expect = 0.0
 Identities = 1242/2000 (62%), Positives = 1508/2000 (75%), Gaps = 94/2000 (4%)

Query: 4    LPPPGPQSFVHFTKQSLALIEQRIAERKSKEPK--EEKKDD--DEEAPKPSSDLEAGKQL 59
            L P G  SF  FT++SLA IE+R+AE++++     +E ++   +EEAP+P  DL+A K+L
Sbjct: 5    LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64

Query: 60   PFIYGDIPPGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRIS 119
            P +YG+ P  ++ EPLEDLDP+Y+ +KTFIVLNKGKTIFRF+AT ALY+LSPF P+RR +
Sbjct: 65   PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124

Query: 120  IKILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKILARGFCVG 179
            +KILVHSLF+MLIMCTILTNC+FM  ++PP WTK VEYTFT IYTFESLVKILARGFC+ 
Sbjct: 125  VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184

Query: 180  EFTFLRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 239
             FTFLRDPWNWLDF VI+ AY++E + LGN+SALRTFRVLRALKTISVIPGLKTIVGALI
Sbjct: 185  AFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALI 244

Query: 240  QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETLESI------MNTL 293
            QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNL+HKC RN    N T  S+        +L
Sbjct: 245  QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLVWESL 304

Query: 294  ESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLA 353
            +      + +    G+ D LLCG S+D+G CPEGY C+K G NPD+GYTSFD+F+WAFLA
Sbjct: 305  DLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLA 364

Query: 354  LFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANI 413
            LFRLMTQD WE LYQQTLR+AGK YMIFF++VIFLGSFYL+NLILAVVAMAYEEQNQA I
Sbjct: 365  LFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATI 424

Query: 414  EEAKQKELEFQQMLDRLKKEQEEAEAIAAAAAEYTSIRRSRIMGLSESSSETSKLSSKSA 473
             E ++KE  FQ+ ++ LKKE E             ++    +  +S SS E S L+  ++
Sbjct: 425  AETEEKEKRFQEAMEMLKKEHE-------------ALTIRGVDTVSRSSLEMSPLAPVNS 471

Query: 474  KERRNRRKKKNQKKLSSGEEKGDAEKLSKSESEDSIRRKSFHLGVEGHRRAHEKRLSTPN 533
             ERR++R+K+    +SSG E+   ++L KS+SED  R  + HL +        + LS  +
Sbjct: 472  HERRSKRRKR----MSSGTEECGEDRLPKSDSEDGPRAMN-HLSLT-------RGLSRTS 519

Query: 534  QSPLSIRGSLFSARRSSRTSLFSFKGRGRDIGSETEFADDEHSIFGDNESRRGSLFVPHR 593
              P S RGS+F+ RR             RD+GSE +FADDE+S  G++ES   SL VP  
Sbjct: 520  MKPRSSRGSIFTFRR-------------RDLGSEADFADDENSTAGESESHHTSLLVPWP 566

Query: 594  PQERRSSNISQASRSPPMLPVNGKMHSAVDCNGVVSLVD-GRSALMLPNGQLL------- 645
             +   +        S P   ++GK +S VDCNGVVSL+  G      P   LL       
Sbjct: 567  LRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGVVSLLGAGDPEATSPGSHLLRPVMLEH 626

Query: 646  PEGTTNQIHKK---RRCSSYLLSEDMLNDPNLRQRAMSRASILTNTVEELEESRQKCPPW 702
            P  TT    +    +  +S     D   +P  RQRA+S  S+LT+ +EELEESR KCPP 
Sbjct: 627  PPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSVLTSALEELEESRHKCPPC 686

Query: 703  WYRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFK 762
            W R A ++LIW C P W+  K+ +  +VMDPF DL IT+CIVLNTLFMA+EH+ MT EF+
Sbjct: 687  WNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFE 746

Query: 763  NVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADVEGLSV 822
             +L +GNLVFTGIF AEM  K+IA+DPY YFQ GWNIFDS+IV LSL+EL L+ +  LSV
Sbjct: 747  EMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSV 806

Query: 823  LRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYK 882
            LRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGK+Y 
Sbjct: 807  LRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYS 866

Query: 883  ECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVYMMVMV 942
            E   + +D   LPRWHM DFFH+FLI+FR+LCGEWIETMWDCMEV+GQ++CL+V+++VMV
Sbjct: 867  EL--RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDCMEVSGQSLCLLVFLLVMV 924

Query: 943  IGNLVVLNLFLALLLSSFSSDNLTAIEEDPDANNLQIAVTRIKKGINYVKQTLREFILKA 1002
            IGNLVVLNLFLALLLSSFS+DNLTA +ED + NNLQ+A+ RI++G+ +VK+T  +F    
Sbjct: 925  IGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGL 984

Query: 1003 FSKKPKISREIRQAEDLNTKKENYISNHTLAEMSKGHNFLKEKDKISGFGSSVDKHLMED 1062
              ++P+    +     L +      S     E  K     KE     G           +
Sbjct: 985  LRQRPQKPAALAAQGQLPSCIATPYSPPP-PETEKVPPTRKETRFEEG-----------E 1032

Query: 1063 SDGQSFIHNPSLTVTVPIAPGESDLENMNAEELSSDSDSEYSKVRLNRSSSSECSTVDNP 1122
              GQ    +P   V VPIA  ESD ++   +E +S    E S  +    S SE ST D  
Sbjct: 1033 QPGQGTPGDPE-PVCVPIAVAESDTDDQEEDEENSLGTEEESSKQTPEDSCSEGSTAD-- 1089

Query: 1123 LPGEGEEAEAEP---MNSDEPEACFTDGCVRRFSCCQVNIESGKGKIWWNIRKTCYKIVE 1179
            +    E  E  P    +  +PE CFT+GCVRR  CC V+     GK+WW +RKTCY IVE
Sbjct: 1090 MTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHIVE 1149

Query: 1180 HSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILEMLLKWIAYGY 1239
            HSWFE+FI+ MILLSSGALAFEDIY+E +KTIK++LEYADK+FTY+F+LEMLLKW+AYG+
Sbjct: 1150 HSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGF 1209

Query: 1240 KTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVV 1299
            K YFTNAWCWLDFLIVDVSLV+LVANTLG++++GPIKSLRTLRALRPLRALSRFEGMRVV
Sbjct: 1210 KKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVV 1269

Query: 1300 VNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDGSRFPASQ--VPNRS 1357
            VNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF  CIN T+G   P +   V N+S
Sbjct: 1270 VNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGD-LPLNYTIVNNKS 1328

Query: 1358 ECFALMNVSQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYE 1417
            +C +L N++  + W  +KVNFDNVG GYL+LLQVATFKGW  IMYAAVDS   ++QP++E
Sbjct: 1329 QCESL-NLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWE 1387

Query: 1418 YSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKL 1477
            Y+LYMYIYFV+FIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKL
Sbjct: 1388 YNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKL 1447

Query: 1478 GSKKPQKPIPRPGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLY 1537
            GSKKPQKPIPRP NK QG IFD+VT QAFD++IM LICLNMVTMMVE + QS     +L 
Sbjct: 1448 GSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILA 1507

Query: 1538 WINVVFIILFTGECVLKLISLRHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTL 1597
             IN++F+ +FTGEC++KL +LRHYYFT  WNIFDFVVVI+SIVG  L+D+I+ YF SPTL
Sbjct: 1508 KINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTL 1567

Query: 1598 FRVIRLARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAY 1657
            FRVIRLARIGRILRL++GAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY+IFGM+NFAY
Sbjct: 1568 FRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAY 1627

Query: 1658 VKKEDGINDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEG 1717
            VK E GI+DMFNF+TF NSM+CLFQITTSAGWDGLL+PILN+ PP CDP   +   S  G
Sbjct: 1628 VKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGS-RG 1686

Query: 1718 DCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWEK 1777
            DCG+P+VGI +F +YIIISFL+VVNMYIA+ILENFSVATEESTEPLSEDDF+MFYE+WEK
Sbjct: 1687 DCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEK 1746

Query: 1778 FDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKR 1837
            FDP+ATQFIE+S LSDFA AL  PL IAKPN++ LI MDLPMVSGDRIHC+DILFAFTKR
Sbjct: 1747 FDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKR 1806

Query: 1838 VLGESGEMDSLRSQMEERFMSANPSKVSYEPITTTLKRKQEDVSATVIQRAYRRYRLRQN 1897
            VLGESGEMD+L+ QMEE+FM+ANPSK+SYEPITTTL+RK E+VSA VIQRA+RR+ L+++
Sbjct: 1807 VLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRS 1866

Query: 1898 VKNISSIYIK---DGDRDDDLLNKKDMAFDNVNENSS----PEKTDATSSTTSPPSYDSV 1950
            +K+ S ++ +    G  ++D   ++ +    ++EN S    P  + + SST+ PPSYDSV
Sbjct: 1867 LKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSV 1926

Query: 1951 TKPDKEKYE---QDRTEKED 1967
            T+   +  +    D +  ED
Sbjct: 1927 TRATSDNLQVRGSDYSHSED 1946


>gi|30089970 voltage-gated sodium channel type V alpha isoform b [Homo
            sapiens]
          Length = 2015

 Score = 2355 bits (6103), Expect = 0.0
 Identities = 1251/2051 (60%), Positives = 1517/2051 (73%), Gaps = 143/2051 (6%)

Query: 4    LPPPGPQSFVHFTKQSLALIEQRIAERKSKEPK--EEKKDD--DEEAPKPSSDLEAGKQL 59
            L P G  SF  FT++SLA IE+R+AE++++     +E ++   +EEAP+P  DL+A K+L
Sbjct: 5    LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64

Query: 60   PFIYGDIPPGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRIS 119
            P +YG+ P  ++ EPLEDLDP+Y+ +KTFIVLNKGKTIFRF+AT ALY+LSPF P+RR +
Sbjct: 65   PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124

Query: 120  IKILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKILARGFCVG 179
            +KILVHSLF+MLIMCTILTNC+FM  ++PP WTK VEYTFT IYTFESLVKILARGFC+ 
Sbjct: 125  VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184

Query: 180  EFTFLRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 239
             FTFLRDPWNWLDF VI+ AY TEFV+LGNVSALRTFRVLRALKTISVI GLKTIVGALI
Sbjct: 185  AFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALI 244

Query: 240  QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETLESI------MNTL 293
            QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNL+HKC RN    N T  S+        +L
Sbjct: 245  QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLVWESL 304

Query: 294  ESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLA 353
            +      + +    G+ D LLCG S+D+G CPEGY C+K G NPD+GYTSFD+F+WAFLA
Sbjct: 305  DLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLA 364

Query: 354  LFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANI 413
            LFRLMTQD WE LYQQTLR+AGK YMIFF++VIFLGSFYL+NLILAVVAMAYEEQNQA I
Sbjct: 365  LFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATI 424

Query: 414  EEAKQKELEFQQMLDRLKKEQEEAEAIAAAAAEYTSIRRSRIMGLSESSSETSKLSSKSA 473
             E ++KE  FQ+ ++ LKKE E             ++    +  +S SS E S L+  ++
Sbjct: 425  AETEEKEKRFQEAMEMLKKEHE-------------ALTIRGVDTVSRSSLEMSPLAPVNS 471

Query: 474  KERRNRRKKKNQKKLSSGEEKGDAEKLSKSESEDSIRRKSFHLGVEGHRRAHEKRLSTPN 533
             ERR++R+K+    +SSG E+   ++L KS+SED  R  + HL +        + LS  +
Sbjct: 472  HERRSKRRKR----MSSGTEECGEDRLPKSDSEDGPRAMN-HLSLT-------RGLSRTS 519

Query: 534  QSPLSIRGSLFSARRSSRTSLFSFKGRGRDIGSETEFADDEHSIFGDNESRRGSLFVPHR 593
              P S RGS+F+ RR             RD+GSE +FADDE+S  G++ES   SL VP  
Sbjct: 520  MKPRSSRGSIFTFRR-------------RDLGSEADFADDENSTAGESESHHTSLLVPWP 566

Query: 594  PQERRSSNISQASRSPPMLPVNGKMHSAVDCNGVVSLVD-GRSALMLPNGQLL------- 645
             +   +        S P   ++GK +S VDCNGVVSL+  G      P   LL       
Sbjct: 567  LRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGVVSLLGAGDPEATSPGSHLLRPVMLEH 626

Query: 646  PEGTTNQIHKK---RRCSSYLLSEDMLNDPNLRQRAMSRASILTNTVEELEESRQKCPPW 702
            P  TT    +    +  +S     D   +P  RQRA+S  S+LT+ +EELEESR KCPP 
Sbjct: 627  PPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSVLTSALEELEESRHKCPPC 686

Query: 703  WYRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFK 762
            W R A ++LIW C P W+  K+ +  +VMDPF DL IT+CIVLNTLFMA+EH+ MT EF+
Sbjct: 687  WNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFE 746

Query: 763  NVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADVEGLSV 822
             +L +GNLVFTGIF AEM  K+IA+DPY YFQ GWNIFDS+IV LSL+EL L+ +  LSV
Sbjct: 747  EMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSV 806

Query: 823  LRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYK 882
            LRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGK+Y 
Sbjct: 807  LRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYS 866

Query: 883  ECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVYMMVMV 942
            E   + +D   LPRWHM DFFH+FLI+FR+LCGEWIETMWDCMEV+GQ++CL+V+++VMV
Sbjct: 867  EL--RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDCMEVSGQSLCLLVFLLVMV 924

Query: 943  IGNLVVLNLFLALLLSSFSSDNLTAIEEDPDANNLQIAVTRIKKGINYVKQTLREFILKA 1002
            IGNLVVLNLFLALLLSSFS+DNLTA +ED + NNLQ+A+ RI++G+ +VK+T  +F    
Sbjct: 925  IGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGL 984

Query: 1003 FSKKPKISREIRQAEDLNTKKENYISNHTLAEMSKGHNFLKEKDKISGFGSSVDKHLMED 1062
              ++P+    +     L +      S     E  K     KE     G           +
Sbjct: 985  LRQRPQKPAALAAQGQLPSCIATPYSPPP-PETEKVPPTRKETRFEEG-----------E 1032

Query: 1063 SDGQSFIHNPSLTVTVPIAPGESDLEN--------MNAEELSSDSDSE------------ 1102
              GQ    +P   V VPIA  ESD ++        +  EE SS  +S+            
Sbjct: 1033 QPGQGTPGDPE-PVCVPIAVAESDTDDQEEDEENSLGTEEESSKQESQPVSGGPEAPPDS 1091

Query: 1103 --YSKVRLNRSSSSECST----------VDNPLPGEGEEAE--------AEPMNSDE--- 1139
              +S+V    SS +E S            +   PG GE  E        A+  N+ E   
Sbjct: 1092 RTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGSTADMTNTAELLE 1151

Query: 1140 -----------PEACFTDGCVRRFSCCQVNIESGKGKIWWNIRKTCYKIVEHSWFESFIV 1188
                       PE CFT+GCVRR  CC V+     GK+WW +RKTCY IVEHSWFE+FI+
Sbjct: 1152 QIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWFETFII 1211

Query: 1189 LMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILEMLLKWIAYGYKTYFTNAWC 1248
             MILLSSGALAFEDIY+E +KTIK++LEYADK+FTY+F+LEMLLKW+AYG+K YFTNAWC
Sbjct: 1212 FMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWC 1271

Query: 1249 WLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIP 1308
            WLDFLIVDVSLV+LVANTLG++++GPIKSLRTLRALRPLRALSRFEGMRVVVNAL+GAIP
Sbjct: 1272 WLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIP 1331

Query: 1309 SIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDGSRFPASQ--VPNRSECFALMNVS 1366
            SIMNVLLVCLIFWLIFSIMGVNLFAGKF  CIN T+G   P +   V N+S+C +L N++
Sbjct: 1332 SIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGD-LPLNYTIVNNKSQCESL-NLT 1389

Query: 1367 QNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYF 1426
              + W  +KVNFDNVG GYL+LLQVATFKGW  IMYAAVDS   ++QP++EY+LYMYIYF
Sbjct: 1390 GELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYF 1449

Query: 1427 VVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPI 1486
            V+FIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPI
Sbjct: 1450 VIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPI 1509

Query: 1487 PRPGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIIL 1546
            PRP NK QG IFD+VT QAFD++IM LICLNMVTMMVE + QS     +L  IN++F+ +
Sbjct: 1510 PRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAI 1569

Query: 1547 FTGECVLKLISLRHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRLARI 1606
            FTGEC++KL +LRHYYFT  WNIFDFVVVI+SIVG  L+D+I+ YF SPTLFRVIRLARI
Sbjct: 1570 FTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARI 1629

Query: 1607 GRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEDGIND 1666
            GRILRL++GAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY+IFGM+NFAYVK E GI+D
Sbjct: 1630 GRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDD 1689

Query: 1667 MFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGI 1726
            MFNF+TF NSM+CLFQITTSAGWDGLL+PILN+ PP CDP   +   S  GDCG+P+VGI
Sbjct: 1690 MFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGS-RGDCGSPAVGI 1748

Query: 1727 FYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWEKFDPDATQFI 1786
             +F +YIIISFL+VVNMYIA+ILENFSVATEESTEPLSEDDF+MFYE+WEKFDP+ATQFI
Sbjct: 1749 LFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFI 1808

Query: 1787 EFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMD 1846
            E+S LSDFA AL  PL IAKPN++ LI MDLPMVSGDRIHC+DILFAFTKRVLGESGEMD
Sbjct: 1809 EYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKRVLGESGEMD 1868

Query: 1847 SLRSQMEERFMSANPSKVSYEPITTTLKRKQEDVSATVIQRAYRRYRLRQNVKNISSIYI 1906
            +L+ QMEE+FM+ANPSK+SYEPITTTL+RK E+VSA VIQRA+RR+ L++++K+ S ++ 
Sbjct: 1869 ALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRSLKHASFLFR 1928

Query: 1907 K---DGDRDDDLLNKKDMAFDNVNENSS----PEKTDATSSTTSPPSYDSVTKPDKEKYE 1959
            +    G  ++D   ++ +    ++EN S    P  + + SST+ PPSYDSVT+   +  +
Sbjct: 1929 QQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSVTRATSDNLQ 1988

Query: 1960 ---QDRTEKED 1967
                D +  ED
Sbjct: 1989 VRGSDYSHSED 1999


>gi|37622907 voltage-gated sodium channel type V alpha isoform a [Homo
            sapiens]
          Length = 2016

 Score = 2353 bits (6097), Expect = 0.0
 Identities = 1249/2052 (60%), Positives = 1514/2052 (73%), Gaps = 144/2052 (7%)

Query: 4    LPPPGPQSFVHFTKQSLALIEQRIAERKSKEPK--EEKKDD--DEEAPKPSSDLEAGKQL 59
            L P G  SF  FT++SLA IE+R+AE++++     +E ++   +EEAP+P  DL+A K+L
Sbjct: 5    LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64

Query: 60   PFIYGDIPPGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRIS 119
            P +YG+ P  ++ EPLEDLDP+Y+ +KTFIVLNKGKTIFRF+AT ALY+LSPF P+RR +
Sbjct: 65   PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124

Query: 120  IKILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKILARGFCVG 179
            +KILVHSLF+MLIMCTILTNC+FM  ++PP WTK VEYTFT IYTFESLVKILARGFC+ 
Sbjct: 125  VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184

Query: 180  EFTFLRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 239
             FTFLRDPWNWLDF VI+ AY TEFV+LGNVSALRTFRVLRALKTISVI GLKTIVGALI
Sbjct: 185  AFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALI 244

Query: 240  QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETLESI------MNTL 293
            QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNL+HKC RN    N T  S+        +L
Sbjct: 245  QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLVWESL 304

Query: 294  ESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLA 353
            +      + +    G+ D LLCG S+D+G CPEGY C+K G NPD+GYTSFD+F+WAFLA
Sbjct: 305  DLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLA 364

Query: 354  LFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANI 413
            LFRLMTQD WE LYQQTLR+AGK YMIFF++VIFLGSFYL+NLILAVVAMAYEEQNQA I
Sbjct: 365  LFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATI 424

Query: 414  EEAKQKELEFQQMLDRLKKEQEEAEAIAAAAAEYTSIRRSRIMGLSESSSETSKLSSKSA 473
             E ++KE  FQ+ ++ LKKE E             ++    +  +S SS E S L+  ++
Sbjct: 425  AETEEKEKRFQEAMEMLKKEHE-------------ALTIRGVDTVSRSSLEMSPLAPVNS 471

Query: 474  KERRNRRKKKNQKKLSSGEEKGDAEKLSKSESEDSIRRKSFHLGVEGHRRAHEKRLSTPN 533
             ERR++R+K+    +SSG E+   ++L KS+SED  R  + HL +        + LS  +
Sbjct: 472  HERRSKRRKR----MSSGTEECGEDRLPKSDSEDGPRAMN-HLSLT-------RGLSRTS 519

Query: 534  QSPLSIRGSLFSARRSSRTSLFSFKGRGRDIGSETEFADDEHSIFGDNESRRGSLFVPHR 593
              P S RGS+F+ RR             RD+GSE +FADDE+S  G++ES   SL VP  
Sbjct: 520  MKPRSSRGSIFTFRR-------------RDLGSEADFADDENSTAGESESHHTSLLVPWP 566

Query: 594  PQERRSSNISQASRSPPMLPVNGKMHSAVDCNGVVSLVD-GRSALMLPNGQLL------- 645
             +   +        S P   ++GK +S VDCNGVVSL+  G      P   LL       
Sbjct: 567  LRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGVVSLLGAGDPEATSPGSHLLRPVMLEH 626

Query: 646  PEGTTNQIHKK---RRCSSYLLSEDMLNDPNLRQRAMSRASILTNTVEELEESRQKCPPW 702
            P  TT    +    +  +S     D   +P  RQRA+S  S+LT+ +EELEESR KCPP 
Sbjct: 627  PPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSVLTSALEELEESRHKCPPC 686

Query: 703  WYRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFK 762
            W R A ++LIW C P W+  K+ +  +VMDPF DL IT+CIVLNTLFMA+EH+ MT EF+
Sbjct: 687  WNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFE 746

Query: 763  NVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADVEGLSV 822
             +L +GNLVFTGIF AEM  K+IA+DPY YFQ GWNIFDS+IV LSL+EL L+ +  LSV
Sbjct: 747  EMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSV 806

Query: 823  LRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYK 882
            LRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGK+Y 
Sbjct: 807  LRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYS 866

Query: 883  ECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVYMMVMV 942
            E   + +D   LPRWHM DFFH+FLI+FR+LCGEWIETMWDCMEV+GQ++CL+V+++VMV
Sbjct: 867  EL--RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDCMEVSGQSLCLLVFLLVMV 924

Query: 943  IGNLVVLNLFLALLLSSFSSDNLTAIEEDPDANNLQIAVTRIKKGINYVKQTLREFILKA 1002
            IGNLVVLNLFLALLLSSFS+DNLTA +ED + NNLQ+A+ RI++G+ +VK+T  +F    
Sbjct: 925  IGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGL 984

Query: 1003 FSKKPKISREIRQAEDLNTKKENYISNHTLAEMSKGHNFLKEKDKISGFGSSVDKHLMED 1062
              ++P+    +     L +      S     E  K     KE     G           +
Sbjct: 985  LRQRPQKPAALAAQGQLPSCIATPYSPPP-PETEKVPPTRKETRFEEG-----------E 1032

Query: 1063 SDGQSFIHNPSLTVTVPIAPGESDLENMNAEELSSDSDSE-------------------- 1102
              GQ    +P   V VPIA  ESD ++   +E +S    E                    
Sbjct: 1033 QPGQGTPGDPE-PVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQPVSGGPEAPPD 1091

Query: 1103 ---YSKVRLNRSSSSECST----------VDNPLPGEGEEAE--------AEPMNSDE-- 1139
               +S+V    SS +E S            +   PG GE  E        A+  N+ E  
Sbjct: 1092 SRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGSTADMTNTAELL 1151

Query: 1140 ------------PEACFTDGCVRRFSCCQVNIESGKGKIWWNIRKTCYKIVEHSWFESFI 1187
                        PE CFT+GCVRR  CC V+     GK+WW +RKTCY IVEHSWFE+FI
Sbjct: 1152 EQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWFETFI 1211

Query: 1188 VLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILEMLLKWIAYGYKTYFTNAW 1247
            + MILLSSGALAFEDIY+E +KTIK++LEYADK+FTY+F+LEMLLKW+AYG+K YFTNAW
Sbjct: 1212 IFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAW 1271

Query: 1248 CWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAI 1307
            CWLDFLIVDVSLV+LVANTLG++++GPIKSLRTLRALRPLRALSRFEGMRVVVNAL+GAI
Sbjct: 1272 CWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAI 1331

Query: 1308 PSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDGSRFPASQ--VPNRSECFALMNV 1365
            PSIMNVLLVCLIFWLIFSIMGVNLFAGKF  CIN T+G   P +   V N+S+C +L N+
Sbjct: 1332 PSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGD-LPLNYTIVNNKSQCESL-NL 1389

Query: 1366 SQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIY 1425
            +  + W  +KVNFDNVG GYL+LLQVATFKGW  IMYAAVDS   ++QP++EY+LYMYIY
Sbjct: 1390 TGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIY 1449

Query: 1426 FVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKP 1485
            FV+FIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKP
Sbjct: 1450 FVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKP 1509

Query: 1486 IPRPGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFII 1545
            IPRP NK QG IFD+VT QAFD++IM LICLNMVTMMVE + QS     +L  IN++F+ 
Sbjct: 1510 IPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVA 1569

Query: 1546 LFTGECVLKLISLRHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRLAR 1605
            +FTGEC++KL +LRHYYFT  WNIFDFVVVI+SIVG  L+D+I+ YF SPTLFRVIRLAR
Sbjct: 1570 IFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLAR 1629

Query: 1606 IGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEDGIN 1665
            IGRILRL++GAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY+IFGM+NFAYVK E GI+
Sbjct: 1630 IGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGID 1689

Query: 1666 DMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVG 1725
            DMFNF+TF NSM+CLFQITTSAGWDGLL+PILN+ PP CDP   +   S  GDCG+P+VG
Sbjct: 1690 DMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGS-RGDCGSPAVG 1748

Query: 1726 IFYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWEKFDPDATQF 1785
            I +F +YIIISFL+VVNMYIA+ILENFSVATEESTEPLSEDDF+MFYE+WEKFDP+ATQF
Sbjct: 1749 ILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQF 1808

Query: 1786 IEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEM 1845
            IE+S LSDFA AL  PL IAKPN++ LI MDLPMVSGDRIHC+DILFAFTKRVLGESGEM
Sbjct: 1809 IEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKRVLGESGEM 1868

Query: 1846 DSLRSQMEERFMSANPSKVSYEPITTTLKRKQEDVSATVIQRAYRRYRLRQNVKNISSIY 1905
            D+L+ QMEE+FM+ANPSK+SYEPITTTL+RK E+VSA VIQRA+RR+ L++++K+ S ++
Sbjct: 1869 DALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRSLKHASFLF 1928

Query: 1906 IK---DGDRDDDLLNKKDMAFDNVNENSS----PEKTDATSSTTSPPSYDSVTKPDKEKY 1958
             +    G  ++D   ++ +    ++EN S    P  + + SST+ PPSYDSVT+   +  
Sbjct: 1929 RQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSVTRATSDNL 1988

Query: 1959 E---QDRTEKED 1967
            +    D +  ED
Sbjct: 1989 QVRGSDYSHSED 2000


>gi|150417967 voltage-gated sodium channel type V alpha isoform c
            [Homo sapiens]
          Length = 2016

 Score = 2350 bits (6089), Expect = 0.0
 Identities = 1246/2052 (60%), Positives = 1514/2052 (73%), Gaps = 144/2052 (7%)

Query: 4    LPPPGPQSFVHFTKQSLALIEQRIAERKSKEPK--EEKKDD--DEEAPKPSSDLEAGKQL 59
            L P G  SF  FT++SLA IE+R+AE++++     +E ++   +EEAP+P  DL+A K+L
Sbjct: 5    LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64

Query: 60   PFIYGDIPPGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRIS 119
            P +YG+ P  ++ EPLEDLDP+Y+ +KTFIVLNKGKTIFRF+AT ALY+LSPF P+RR +
Sbjct: 65   PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124

Query: 120  IKILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKILARGFCVG 179
            +KILVHSLF+MLIMCTILTNC+FM  ++PP WTK VEYTFT IYTFESLVKILARGFC+ 
Sbjct: 125  VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184

Query: 180  EFTFLRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 239
             FTFLRDPWNWLDF VI+ AY++E + LGN+SALRTFRVLRALKTISVIPGLKTIVGALI
Sbjct: 185  AFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALI 244

Query: 240  QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETLESI------MNTL 293
            QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNL+HKC RN    N T  S+        +L
Sbjct: 245  QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLVWESL 304

Query: 294  ESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLA 353
            +      + +    G+ D LLCG S+D+G CPEGY C+K G NPD+GYTSFD+F+WAFLA
Sbjct: 305  DLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLA 364

Query: 354  LFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANI 413
            LFRLMTQD WE LYQQTLR+AGK YMIFF++VIFLGSFYL+NLILAVVAMAYEEQNQA I
Sbjct: 365  LFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATI 424

Query: 414  EEAKQKELEFQQMLDRLKKEQEEAEAIAAAAAEYTSIRRSRIMGLSESSSETSKLSSKSA 473
             E ++KE  FQ+ ++ LKKE E             ++    +  +S SS E S L+  ++
Sbjct: 425  AETEEKEKRFQEAMEMLKKEHE-------------ALTIRGVDTVSRSSLEMSPLAPVNS 471

Query: 474  KERRNRRKKKNQKKLSSGEEKGDAEKLSKSESEDSIRRKSFHLGVEGHRRAHEKRLSTPN 533
             ERR++R+K+    +SSG E+   ++L KS+SED  R  + HL +        + LS  +
Sbjct: 472  HERRSKRRKR----MSSGTEECGEDRLPKSDSEDGPRAMN-HLSLT-------RGLSRTS 519

Query: 534  QSPLSIRGSLFSARRSSRTSLFSFKGRGRDIGSETEFADDEHSIFGDNESRRGSLFVPHR 593
              P S RGS+F+ RR             RD+GSE +FADDE+S  G++ES   SL VP  
Sbjct: 520  MKPRSSRGSIFTFRR-------------RDLGSEADFADDENSTAGESESHHTSLLVPWP 566

Query: 594  PQERRSSNISQASRSPPMLPVNGKMHSAVDCNGVVSLVD-GRSALMLPNGQLL------- 645
             +   +        S P   ++GK +S VDCNGVVSL+  G      P   LL       
Sbjct: 567  LRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGVVSLLGAGDPEATSPGSHLLRPVMLEH 626

Query: 646  PEGTTNQIHKK---RRCSSYLLSEDMLNDPNLRQRAMSRASILTNTVEELEESRQKCPPW 702
            P  TT    +    +  +S     D   +P  RQRA+S  S+LT+ +EELEESR KCPP 
Sbjct: 627  PPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSVLTSALEELEESRHKCPPC 686

Query: 703  WYRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFK 762
            W R A ++LIW C P W+  K+ +  +VMDPF DL IT+CIVLNTLFMA+EH+ MT EF+
Sbjct: 687  WNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFE 746

Query: 763  NVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADVEGLSV 822
             +L +GNLVFTGIF AEM  K+IA+DPY YFQ GWNIFDS+IV LSL+EL L+ +  LSV
Sbjct: 747  EMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSV 806

Query: 823  LRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYK 882
            LRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGK+Y 
Sbjct: 807  LRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYS 866

Query: 883  ECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVYMMVMV 942
            E   + +D   LPRWHM DFFH+FLI+FR+LCGEWIETMWDCMEV+GQ++CL+V+++VMV
Sbjct: 867  EL--RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDCMEVSGQSLCLLVFLLVMV 924

Query: 943  IGNLVVLNLFLALLLSSFSSDNLTAIEEDPDANNLQIAVTRIKKGINYVKQTLREFILKA 1002
            IGNLVVLNLFLALLLSSFS+DNLTA +ED + NNLQ+A+ RI++G+ +VK+T  +F    
Sbjct: 925  IGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGL 984

Query: 1003 FSKKPKISREIRQAEDLNTKKENYISNHTLAEMSKGHNFLKEKDKISGFGSSVDKHLMED 1062
              ++P+    +     L +      S     E  K     KE     G           +
Sbjct: 985  LRQRPQKPAALAAQGQLPSCIATPYSPPP-PETEKVPPTRKETRFEEG-----------E 1032

Query: 1063 SDGQSFIHNPSLTVTVPIAPGESDLENMNAEELSSDSDSE-------------------- 1102
              GQ    +P   V VPIA  ESD ++   +E +S    E                    
Sbjct: 1033 QPGQGTPGDPE-PVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQPVSGGPEAPPD 1091

Query: 1103 ---YSKVRLNRSSSSECST----------VDNPLPGEGEEAE--------AEPMNSDE-- 1139
               +S+V    SS +E S            +   PG GE  E        A+  N+ E  
Sbjct: 1092 SRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGSTADMTNTAELL 1151

Query: 1140 ------------PEACFTDGCVRRFSCCQVNIESGKGKIWWNIRKTCYKIVEHSWFESFI 1187
                        PE CFT+GCVRR  CC V+     GK+WW +RKTCY IVEHSWFE+FI
Sbjct: 1152 EQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWFETFI 1211

Query: 1188 VLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILEMLLKWIAYGYKTYFTNAW 1247
            + MILLSSGALAFEDIY+E +KTIK++LEYADK+FTY+F+LEMLLKW+AYG+K YFTNAW
Sbjct: 1212 IFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAW 1271

Query: 1248 CWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAI 1307
            CWLDFLIVDVSLV+LVANTLG++++GPIKSLRTLRALRPLRALSRFEGMRVVVNAL+GAI
Sbjct: 1272 CWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAI 1331

Query: 1308 PSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDGSRFPASQ--VPNRSECFALMNV 1365
            PSIMNVLLVCLIFWLIFSIMGVNLFAGKF  CIN T+G   P +   V N+S+C +L N+
Sbjct: 1332 PSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGD-LPLNYTIVNNKSQCESL-NL 1389

Query: 1366 SQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIY 1425
            +  + W  +KVNFDNVG GYL+LLQVATFKGW  IMYAAVDS   ++QP++EY+LYMYIY
Sbjct: 1390 TGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIY 1449

Query: 1426 FVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKP 1485
            FV+FIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKP
Sbjct: 1450 FVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKP 1509

Query: 1486 IPRPGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFII 1545
            IPRP NK QG IFD+VT QAFD++IM LICLNMVTMMVE + QS     +L  IN++F+ 
Sbjct: 1510 IPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVA 1569

Query: 1546 LFTGECVLKLISLRHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRLAR 1605
            +FTGEC++KL +LRHYYFT  WNIFDFVVVI+SIVG  L+D+I+ YF SPTLFRVIRLAR
Sbjct: 1570 IFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLAR 1629

Query: 1606 IGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEDGIN 1665
            IGRILRL++GAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY+IFGM+NFAYVK E GI+
Sbjct: 1630 IGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGID 1689

Query: 1666 DMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVG 1725
            DMFNF+TF NSM+CLFQITTSAGWDGLL+PILN+ PP CDP   +   S  GDCG+P+VG
Sbjct: 1690 DMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGS-RGDCGSPAVG 1748

Query: 1726 IFYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWEKFDPDATQF 1785
            I +F +YIIISFL+VVNMYIA+ILENFSVATEESTEPLSEDDF+MFYE+WEKFDP+ATQF
Sbjct: 1749 ILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQF 1808

Query: 1786 IEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEM 1845
            IE+S LSDFA AL  PL IAKPN++ LI MDLPMVSGDRIHC+DILFAFTKRVLGESGEM
Sbjct: 1809 IEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKRVLGESGEM 1868

Query: 1846 DSLRSQMEERFMSANPSKVSYEPITTTLKRKQEDVSATVIQRAYRRYRLRQNVKNISSIY 1905
            D+L+ QMEE+FM+ANPSK+SYEPITTTL+RK E+VSA VIQRA+RR+ L++++K+ S ++
Sbjct: 1869 DALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRSLKHASFLF 1928

Query: 1906 IK---DGDRDDDLLNKKDMAFDNVNENSS----PEKTDATSSTTSPPSYDSVTKPDKEKY 1958
             +    G  ++D   ++ +    ++EN S    P  + + SST+ PPSYDSVT+   +  
Sbjct: 1929 RQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSVTRATSDNL 1988

Query: 1959 E---QDRTEKED 1967
            +    D +  ED
Sbjct: 1989 QVRGSDYSHSED 2000


>gi|150417969 voltage-gated sodium channel type V alpha isoform d
            [Homo sapiens]
          Length = 1998

 Score = 2312 bits (5992), Expect = 0.0
 Identities = 1232/2052 (60%), Positives = 1500/2052 (73%), Gaps = 162/2052 (7%)

Query: 4    LPPPGPQSFVHFTKQSLALIEQRIAERKSKEPK--EEKKDD--DEEAPKPSSDLEAGKQL 59
            L P G  SF  FT++SLA IE+R+AE++++     +E ++   +EEAP+P  DL+A K+L
Sbjct: 5    LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64

Query: 60   PFIYGDIPPGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRIS 119
            P +YG+ P  ++ EPLEDLDP+Y+ +KTFIVLNKGKTIFRF+AT ALY+LSPF P+RR +
Sbjct: 65   PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124

Query: 120  IKILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKILARGFCVG 179
            +KILVHSLF+MLIMCTILTNC+FM  ++PP WTK VEYTFT IYTFESLVKILARGFC+ 
Sbjct: 125  VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184

Query: 180  EFTFLRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 239
             FTFLRDPWNWLDF VI+ AY++E + LGN+SALRTFRVLRALKTISVIPGLKTIVGALI
Sbjct: 185  AFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALI 244

Query: 240  QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETLESI------MNTL 293
            QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNL+HKC RN    N T  S+        +L
Sbjct: 245  QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLVWESL 304

Query: 294  ESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLA 353
            +      + +    G+ D LLCG S+D+G CPEGY C+K G NPD+GYTSFD+F+WAFLA
Sbjct: 305  DLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLA 364

Query: 354  LFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANI 413
            LFRLMTQD WE LYQQTLR+AGK YMIFF++VIFLGSFYL+NLILAVVAMAYEEQNQA I
Sbjct: 365  LFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATI 424

Query: 414  EEAKQKELEFQQMLDRLKKEQEEAEAIAAAAAEYTSIRRSRIMGLSESSSETSKLSSKSA 473
             E ++KE  FQ+ ++ LKKE E             ++    +  +S SS E S L+  ++
Sbjct: 425  AETEEKEKRFQEAMEMLKKEHE-------------ALTIRGVDTVSRSSLEMSPLAPVNS 471

Query: 474  KERRNRRKKKNQKKLSSGEEKGDAEKLSKSESEDSIRRKSFHLGVEGHRRAHEKRLSTPN 533
             ERR++R+K+    +SSG E+   ++L KS+SED  R  + HL +        + LS  +
Sbjct: 472  HERRSKRRKR----MSSGTEECGEDRLPKSDSEDGPRAMN-HLSLT-------RGLSRTS 519

Query: 534  QSPLSIRGSLFSARRSSRTSLFSFKGRGRDIGSETEFADDEHSIFGDNESRRGSLFVPHR 593
              P S RGS+F+ RR             RD+GSE +FADDE+S  G++ES   SL VP  
Sbjct: 520  MKPRSSRGSIFTFRR-------------RDLGSEADFADDENSTAGESESHHTSLLVPWP 566

Query: 594  PQERRSSNISQASRSPPMLPVNGKMHSAVDCNGVVSLVD-GRSALMLPNGQLL------- 645
             +   +        S P   ++GK +S VDCNGVVSL+  G      P   LL       
Sbjct: 567  LRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGVVSLLGAGDPEATSPGSHLLRPVMLEH 626

Query: 646  PEGTTNQIHKK---RRCSSYLLSEDMLNDPNLRQRAMSRASILTNTVEELEESRQKCPPW 702
            P  TT    +    +  +S     D   +P  RQRA+S  S+LT+ +EELEESR KCPP 
Sbjct: 627  PPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSVLTSALEELEESRHKCPPC 686

Query: 703  WYRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFK 762
            W R A ++LIW C P W+  K+ +  +VMDPF DL IT+CIVLNTLFMA+EH+ MT EF+
Sbjct: 687  WNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFE 746

Query: 763  NVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADVEGLSV 822
             +L +GNLVFTGIF AEM  K+IA+DPY YFQ GWNIFDS+IV LSL+EL L+ +  LSV
Sbjct: 747  EMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSV 806

Query: 823  LRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYK 882
            LRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGK+Y 
Sbjct: 807  LRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYS 866

Query: 883  ECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVYMMVMV 942
            E   + +D   LPRWHM DFFH+FLI+FR+LCGEWIETMWDCMEV+GQ++CL+V+++VMV
Sbjct: 867  EL--RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDCMEVSGQSLCLLVFLLVMV 924

Query: 943  IGNLVVLNLFLALLLSSFSSDNLTAIEEDPDANNLQIAVTRIKKGINYVKQTLREFILKA 1002
            IGNLVVLNLFLALLLSSFS+DNLTA +ED + NNLQ+A+ RI++G+ +VK+T  +F    
Sbjct: 925  IGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGL 984

Query: 1003 FSKKPKISREIRQAEDLNTKKENYISNHTLAEMSKGHNFLKEKDKISGFGSSVDKHLMED 1062
              ++P+    +     L +      S     E  K     KE     G           +
Sbjct: 985  LRQRPQKPAALAAQGQLPSCIATPYSPPP-PETEKVPPTRKETRFEEG-----------E 1032

Query: 1063 SDGQSFIHNPSLTVTVPIAPGESDLENMNAEELSSDSDSE-------------------- 1102
              GQ    +P   V VPIA  ESD ++   +E +S    E                    
Sbjct: 1033 QPGQGTPGDPE-PVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQPVSGGPEAPPD 1091

Query: 1103 ---YSKVRLNRSSSSECST----------VDNPLPGEGEEAE--------AEPMNSDE-- 1139
               +S+V    SS +E S            +   PG GE  E        A+  N+ E  
Sbjct: 1092 SRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGSTADMTNTAELL 1151

Query: 1140 ------------PEACFTDGCVRRFSCCQVNIESGKGKIWWNIRKTCYKIVEHSWFESFI 1187
                        PE CFT+GCVRR  CC V+     GK+WW +RKTCY IVEHSWFE+FI
Sbjct: 1152 EQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWFETFI 1211

Query: 1188 VLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILEMLLKWIAYGYKTYFTNAW 1247
            + MILLSSGALAFEDIY+E +KTIK++LEYADK+FTY+F+LEMLLKW+AYG+K YFTNAW
Sbjct: 1212 IFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAW 1271

Query: 1248 CWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAI 1307
            CWLDFLIVDVSLV+LVANTLG++++GPIKSLRTLRALRPLRALSRFEGMRVVVNAL+GAI
Sbjct: 1272 CWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAI 1331

Query: 1308 PSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDGSRFPASQ--VPNRSECFALMNV 1365
            PSIMNVLLVCLIFWLIFSIMGVNLFAGKF  CIN T+G   P +   V N+S+C +L N+
Sbjct: 1332 PSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGD-LPLNYTIVNNKSQCESL-NL 1389

Query: 1366 SQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIY 1425
            +  + W  +KVNFDNVG GYL+LLQV                   ++QP++EY+LYMYIY
Sbjct: 1390 TGELYWTKVKVNFDNVGAGYLALLQV------------------YEEQPQWEYNLYMYIY 1431

Query: 1426 FVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKP 1485
            FV+FIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKP
Sbjct: 1432 FVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKP 1491

Query: 1486 IPRPGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFII 1545
            IPRP NK QG IFD+VT QAFD++IM LICLNMVTMMVE + QS     +L  IN++F+ 
Sbjct: 1492 IPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVA 1551

Query: 1546 LFTGECVLKLISLRHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRLAR 1605
            +FTGEC++KL +LRHYYFT  WNIFDFVVVI+SIVG  L+D+I+ YF SPTLFRVIRLAR
Sbjct: 1552 IFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLAR 1611

Query: 1606 IGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEDGIN 1665
            IGRILRL++GAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY+IFGM+NFAYVK E GI+
Sbjct: 1612 IGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGID 1671

Query: 1666 DMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVG 1725
            DMFNF+TF NSM+CLFQITTSAGWDGLL+PILN+ PP CDP   +   S  GDCG+P+VG
Sbjct: 1672 DMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGS-RGDCGSPAVG 1730

Query: 1726 IFYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWEKFDPDATQF 1785
            I +F +YIIISFL+VVNMYIA+ILENFSVATEESTEPLSEDDF+MFYE+WEKFDP+ATQF
Sbjct: 1731 ILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQF 1790

Query: 1786 IEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEM 1845
            IE+S LSDFA AL  PL IAKPN++ LI MDLPMVSGDRIHC+DILFAFTKRVLGESGEM
Sbjct: 1791 IEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKRVLGESGEM 1850

Query: 1846 DSLRSQMEERFMSANPSKVSYEPITTTLKRKQEDVSATVIQRAYRRYRLRQNVKNISSIY 1905
            D+L+ QMEE+FM+ANPSK+SYEPITTTL+RK E+VSA VIQRA+RR+ L++++K+ S ++
Sbjct: 1851 DALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRSLKHASFLF 1910

Query: 1906 IK---DGDRDDDLLNKKDMAFDNVNENSS----PEKTDATSSTTSPPSYDSVTKPDKEKY 1958
             +    G  ++D   ++ +    ++EN S    P  + + SST+ PPSYDSVT+   +  
Sbjct: 1911 RQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSVTRATSDNL 1970

Query: 1959 E---QDRTEKED 1967
            +    D +  ED
Sbjct: 1971 QVRGSDYSHSED 1982


>gi|237512980 voltage-gated sodium channel type V alpha isoform e
            [Homo sapiens]
          Length = 1983

 Score = 2281 bits (5911), Expect = 0.0
 Identities = 1223/2051 (59%), Positives = 1488/2051 (72%), Gaps = 175/2051 (8%)

Query: 4    LPPPGPQSFVHFTKQSLALIEQRIAERKSKEPK--EEKKDD--DEEAPKPSSDLEAGKQL 59
            L P G  SF  FT++SLA IE+R+AE++++     +E ++   +EEAP+P  DL+A K+L
Sbjct: 5    LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64

Query: 60   PFIYGDIPPGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRIS 119
            P +YG+ P  ++ EPLEDLDP+Y+ +KTFIVLNKGKTIFRF+AT ALY+LSPF P+RR +
Sbjct: 65   PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124

Query: 120  IKILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKILARGFCVG 179
            +KILVHSLF+MLIMCTILTNC+FM  ++PP WTK VEYTFT IYTFESLVKILARGFC+ 
Sbjct: 125  VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184

Query: 180  EFTFLRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 239
             FTFLRDPWNWLDF VI+ AY++E + LGN+SALRTFRVLRALKTISVIPGLKTIVGALI
Sbjct: 185  AFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALI 244

Query: 240  QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETLES------IMNTL 293
            QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNL+HKC RN    N T  S      +  +L
Sbjct: 245  QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLVWESL 304

Query: 294  ESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLA 353
            +      + +    G+ D LLCG S+D+G CPEGY C+K G NPD+GYTSFD+F+WAFLA
Sbjct: 305  DLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLA 364

Query: 354  LFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANI 413
            LFRLMTQD WE LYQQTLR+AGK YMIFF++VIFLGSFYL+NLILAVVAMAYEEQNQA I
Sbjct: 365  LFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATI 424

Query: 414  EEAKQKELEFQQMLDRLKKEQEEAEAIAAAAAEYTSIRRSRIMGLSESSSETSKLSSKSA 473
             E ++KE  FQ+ ++ LKKE E             ++    +  +S SS E S L+  ++
Sbjct: 425  AETEEKEKRFQEAMEMLKKEHE-------------ALTIRGVDTVSRSSLEMSPLAPVNS 471

Query: 474  KERRNRRKKKNQKKLSSGEEKGDAEKLSKSESEDSIRRKSFHLGVEGHRRAHEKRLSTPN 533
             ERR++R+    K++SSG E+   ++L KS+SED  R  + HL +        + LS  +
Sbjct: 472  HERRSKRR----KRMSSGTEECGEDRLPKSDSEDGPRAMN-HLSL-------TRGLSRTS 519

Query: 534  QSPLSIRGSLFSARRSSRTSLFSFKGRGRDIGSETEFADDEHSIFGDNESRRGSLFVPHR 593
              P S RGS+F+ RR             RD+GSE +FADDE+S  G++ES   SL VP  
Sbjct: 520  MKPRSSRGSIFTFRR-------------RDLGSEADFADDENSTAGESESHHTSLLVPWP 566

Query: 594  PQERRSSNISQASRSPPMLPVNGKMHSAVDCNGVVSLVD-GRSALMLPNGQLL------- 645
             +   +        S P   ++GK +S VDCNGVVSL+  G      P   LL       
Sbjct: 567  LRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGVVSLLGAGDPEATSPGSHLLRPVMLEH 626

Query: 646  PEGTTNQIHK---KRRCSSYLLSEDMLNDPNLRQRAMSRASILTNTVEELEESRQKCPPW 702
            P  TT    +    +  +S     D   +P  RQRA+S  S+LT+ +EELEESR KCPP 
Sbjct: 627  PPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSVLTSALEELEESRHKCPPC 686

Query: 703  WYRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFK 762
            W R A ++LIW C P W+  K+ +  +VMDPF DL IT+CIVLNTLFMA+EH+ MT EF+
Sbjct: 687  WNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFE 746

Query: 763  NVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADVEGLSV 822
             +L +GNLVFTGIF AEM  K+IA+DPY YFQ GWNIFDS+IV LSL+EL L+ +  LSV
Sbjct: 747  EMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSV 806

Query: 823  LRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYK 882
            LRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGK+Y 
Sbjct: 807  LRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYS 866

Query: 883  ECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVYMMVMV 942
            E   + +D   LPRWHM DFFH+FLI+FR+LCGEWIETMWDCMEV+GQ++CL+V+++VMV
Sbjct: 867  E--LRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDCMEVSGQSLCLLVFLLVMV 924

Query: 943  IGNLVVLNLFLALLLSSFSSDNLTAIEEDPDANNLQIAVTRIKKGINYVKQTLREFILKA 1002
            IGNLVVLNLFLALLLSSFS+DNLTA +ED + NNLQ+A+ RI++G+ +VK+T  +F    
Sbjct: 925  IGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGL 984

Query: 1003 FSKKPKISREIRQAEDLNTKKENYISNHTLAEMSKGHNFLKEKDKISGFGSSVDKHLMED 1062
              ++P+    +     L +      S     E  K     KE     G           +
Sbjct: 985  LRQRPQKPAALAAQGQLPSCIATPYSPPP-PETEKVPPTRKETRFEEG-----------E 1032

Query: 1063 SDGQSFIHNPSLTVTVPIAPGESDLE--------NMNAEELSSDSDSE------------ 1102
              GQ    +P   V VPIA  ESD +        ++  EE SS  +S+            
Sbjct: 1033 QPGQGTPGDPE-PVCVPIAVAESDTDDQEEDEENSLGTEEESSKQESQPVSGGPEAPPDS 1091

Query: 1103 --YSKVRLNRSSSSECST----------VDNPLPGEGEEAE--------AEPMNSDE--- 1139
              +S+V    SS +E S            +   PG GE  E        A+  N+ E   
Sbjct: 1092 RTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGSTADMTNTAELLE 1151

Query: 1140 -----------PEACFTDGCVRRFSCCQVNIESGKGKIWWNIRKTCYKIVEHSWFESFIV 1188
                       PE CFT+GCVRR  CC V+     GK+WW +RKTCY IVEHSWFE+FI+
Sbjct: 1152 QIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWFETFII 1211

Query: 1189 LMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILEMLLKWIAYGYKTYFTNAWC 1248
             MILLSSGALAFEDIY+E +KTIK++LEYADK+FTY+F+LEMLLKW+AYG+K YFTNAWC
Sbjct: 1212 FMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWC 1271

Query: 1249 WLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIP 1308
            WLDFLIVDVSLV+LVANTLG++++GPIKSLRTLRALRPLRALSRFEGMRVVVNAL+GAIP
Sbjct: 1272 WLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIP 1331

Query: 1309 SIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDGSRFPASQ--VPNRSECFALMNVS 1366
            SIMNVLLVCLIFWLIFSIMGVNLFAGKF  CIN T+G   P +   V N+S+C +L N++
Sbjct: 1332 SIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGD-LPLNYTIVNNKSQCESL-NLT 1389

Query: 1367 QNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYF 1426
              + W  +KVNFDNVG GYL+LLQVATFKGW  IMYAAVDS   ++QP++EY+LYMYIYF
Sbjct: 1390 GELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYF 1449

Query: 1427 VVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPI 1486
            V+FIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPI
Sbjct: 1450 VIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPI 1509

Query: 1487 PRPGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIIL 1546
            PRP NK QG IFD+VT QAFD++IM LICLNMVTMMVE + QS     +L  IN++F+ +
Sbjct: 1510 PRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAI 1569

Query: 1547 FTGECVLKLISLRHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRLARI 1606
            FT                                G  L+D+I+ YF SPTLFRVIRLARI
Sbjct: 1570 FT--------------------------------GTVLSDIIQKYFFSPTLFRVIRLARI 1597

Query: 1607 GRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEDGIND 1666
            GRILRL++GAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY+IFGM+NFAYVK E GI+D
Sbjct: 1598 GRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDD 1657

Query: 1667 MFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGI 1726
            MFNF+TF NSM+CLFQITTSAGWDGLL+PILN+ PP CDP   +   S  GDCG+P+VGI
Sbjct: 1658 MFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGS-RGDCGSPAVGI 1716

Query: 1727 FYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWEKFDPDATQFI 1786
             +F +YIIISFL+VVNMYIA+ILENFSVATEESTEPLSEDDF+MFYE+WEKFDP+ATQFI
Sbjct: 1717 LFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFI 1776

Query: 1787 EFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMD 1846
            E+S LSDFA AL  PL IAKPN++ LI MDLPMVSGDRIHC+DILFAFTKRVLGESGEMD
Sbjct: 1777 EYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKRVLGESGEMD 1836

Query: 1847 SLRSQMEERFMSANPSKVSYEPITTTLKRKQEDVSATVIQRAYRRYRLRQNVKNISSIYI 1906
            +L+ QMEE+FM+ANPSK+SYEPITTTL+RK E+VSA VIQRA+RR+ L++++K+ S ++ 
Sbjct: 1837 ALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRSLKHASFLFR 1896

Query: 1907 K---DGDRDDDLLNKKDMAFDNVNENSS----PEKTDATSSTTSPPSYDSVTKPDKEKYE 1959
            +    G  ++D   ++ +    ++EN S    P  + + SST+ PPSYDSVT+   +  +
Sbjct: 1897 QQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSVTRATSDNLQ 1956

Query: 1960 ---QDRTEKED 1967
                D +  ED
Sbjct: 1957 VRGSDYSHSED 1967


>gi|110835710 sodium channel, voltage-gated, type X, alpha [Homo
            sapiens]
          Length = 1956

 Score = 2086 bits (5404), Expect = 0.0
 Identities = 1122/2033 (55%), Positives = 1419/2033 (69%), Gaps = 164/2033 (8%)

Query: 11   SFVHFTKQSLALIEQRIAERKSKEPKEEK---KDDDEEAPKPSSDLEAGKQLPFIYGDIP 67
            +F  FT +SL  IE++IA ++  +   EK   + D EE P+P  DL+A  QLP  YG++P
Sbjct: 12   NFRRFTPESLVEIEKQIAAKQGTKKAREKHREQKDQEEKPRPQLDLKACNQLPKFYGELP 71

Query: 68   PGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRISIKILVHSL 127
              ++ EPLEDLDP+Y+  +TF+VLNKG+TI RF+AT AL++ SPF+ +RR +IK+ VHS 
Sbjct: 72   AELIGEPLEDLDPFYSTHRTFMVLNKGRTISRFSATRALWLFSPFNLIRRTAIKVSVHSW 131

Query: 128  FSMLIMCTILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKILARGFCVGEFTFLRDP 187
            FS+ I  TIL NC+ MT  + P+    +EY FT IYTFE+L+KILARGFC+ EFT+LRDP
Sbjct: 132  FSLFITVTILVNCVCMTRTDLPE---KIEYVFTVIYTFEALIKILARGFCLNEFTYLRDP 188

Query: 188  WNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSD 247
            WNWLDF VI  AY+   ++L  +S LRTFRVLRALKT+SVIPGLK IVGALI SVKKL+D
Sbjct: 189  WNWLDFSVITLAYVGTAIDLRGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLAD 248

Query: 248  VMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETLESIMNTLESEEDFRKYFYYLE 307
            V ILT+FCLSVFAL+GLQLF GNLK+KC +N +  NET         +    RK   Y+ 
Sbjct: 249  VTILTIFCLSVFALVGLQLFKGNLKNKCVKNDMAVNETT--------NYSSHRKPDIYIN 300

Query: 308  --GSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQDYWEN 365
              G+ D LLCG  +DSG CP+GY C+K   NPD+ YTSFD+F+WAFL+LFRLMTQD WE 
Sbjct: 301  KRGTSDPLLCGNGSDSGHCPDGYICLKTSDNPDFNYTSFDSFAWAFLSLFRLMTQDSWER 360

Query: 366  LYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANIEEAKQKELEFQQ 425
            LYQQTLR +GK YMIFFV+VIFLGSFYL+NLILAVV MAYEEQNQA  +E + KE +FQ+
Sbjct: 361  LYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAYEEQNQATTDEIEAKEKKFQE 420

Query: 426  MLDRLKKEQEEAEAIAAAAAEYTSIRRSRIMGLSESSSETSKLSSKSAKERRNRRKKKNQ 485
             L+ L+KEQE    +AA   + TS+           S   S L+SK+A ERR+R K +  
Sbjct: 421  ALEMLRKEQE---VLAALGIDTTSLH----------SHNGSPLTSKNASERRHRIKPR-- 465

Query: 486  KKLSSGEEKGDAEKLSKSESEDSIRRKSFHLGVEGHRRAHEKRLSTPNQSPLSIRGSLFS 545
                          +S+  +ED+                   R    NQ  +S  G    
Sbjct: 466  --------------VSEGSTEDN----------------KSPRSDPYNQRRMSFLGLASG 495

Query: 546  ARRSSRTSLFSFKGRGRDIGSETEFADDEHSIF-GDNESRRGSLFVPHRPQERRSSNISQ 604
             RR+S  S+F F+  GRDI       DD   +F GD+ES RGSL +     ++       
Sbjct: 496  KRRASHGSVFHFRSPGRDISLPEGVTDD--GVFPGDHESHRGSLLLGGGAGQQ-----GP 548

Query: 605  ASRSPPMLPVNGKMHSAVDCNGVVSLVDGRSALMLPNGQLLPEGTTNQIHKKRRCSSYLL 664
              RSP   P N       D +              P  +L P           +  ++L 
Sbjct: 549  LPRSPLPQPSNPDSRHGEDEHQPP-----------PTSELAPGAVDVSAFDAGQKKTFL- 596

Query: 665  SEDMLNDPNLRQRAMSRASILTNTVEELEESRQKCPPWWYRFAHKFLIWNCSPYWIKFKK 724
            S + L++P   QRAMS  SI+T+ +EELEES QKCPP     + K+LIW+C P W+K K 
Sbjct: 597  SAEYLDEPFRAQRAMSVVSIITSVLEELEESEQKCPPCLTSLSQKYLIWDCCPMWVKLKT 656

Query: 725  CIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAIGNLVFTGIFAAEMVLKL 784
             ++ +V DPF +L IT+CIV+NT+FMAMEHH M+  F+ +L IGN+VFT  F AEMV K+
Sbjct: 657  ILFGLVTDPFAELTITLCIVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKI 716

Query: 785  IAMDPYEYFQVGWNIFDSLIVTLSLVELFLADVEGLSVLRSFRLLRVFKLAKSWPTLNML 844
            IA DPY YFQ  WNIFD +IVT+SL+EL +A    LSVLRSFRLLRVFKLAKSWPTLN L
Sbjct: 717  IAFDPYYYFQKKWNIFDCIIVTVSLLELGVAKKGSLSVLRSFRLLRVFKLAKSWPTLNTL 776

Query: 845  IKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYK---ECVCKINDDCTLPRWHMND 901
            IKIIGNSVGALGNLT++LAIIVF+FA+VG QL G++Y+   + +   ++D   PRWHM+D
Sbjct: 777  IKIIGNSVGALGNLTIILAIIVFVFALVGKQLLGENYRNNRKNISAPHEDW--PRWHMHD 834

Query: 902  FFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVYMMVMVIGNLVVLNLFLALLLSSFS 961
            FFHSFLIVFR+LCGEWIE MW CMEV  +++CLI+++ VMV+GNLVVLNLF+ALLL+SFS
Sbjct: 835  FFHSFLIVFRILCGEWIENMWACMEVGQKSICLILFLTVMVLGNLVVLNLFIALLLNSFS 894

Query: 962  SDNLTAIEEDPDANNLQIAVTRIKKGINYVKQTLREFILKAFS-KKPKISREIRQAEDLN 1020
            +DNLTA E+D + NNLQ+A+ RI+   +  KQ L  F  ++    +PK   E+     L+
Sbjct: 895  ADNLTAPEDDGEVNNLQVALARIQVFGHRTKQALCSFFSRSCPFPQPKAEPELVVKLPLS 954

Query: 1021 TKK-ENYISNHTLAEMSKGHNFLKEKDKISGFGSSVDKHLMEDSDGQSFIHNPSLTVTVP 1079
            + K EN+I+ +T    S G         +       D+H         FI NP++ V+VP
Sbjct: 955  SSKAENHIAANTARGSSGG---------LQAPRGPRDEH-------SDFIANPTVWVSVP 998

Query: 1080 IAPGESDLENM-------------------------------------------NAEELS 1096
            IA GESDL+++                                           ++E+L+
Sbjct: 999  IAEGESDLDDLEDDGGEDAQSFQQEVIPKGQQEQLQQVERCGDHLTPRSPGTGTSSEDLA 1058

Query: 1097 --------SDSDSEYSKVRLNRSSSSECSTVDNPLPGEGEEAEAEPMNS-DEPEACFTDG 1147
                     +S  +     ++ +SSSE STVD   P E      E  +  +EP+ CFT+G
Sbjct: 1059 PSLGETWKDESVPQVPAEGVDDTSSSEGSTVDCLDPEEILRKIPELADDLEEPDDCFTEG 1118

Query: 1148 CVRRFSCCQVNIESGKGKIWWNIRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYIER 1207
            C+R   CC+++       + W +RKTCY+IVEHSWFESFI+ MILLSSG+LAFED Y+++
Sbjct: 1119 CIRHCPCCKLDTTKSPWDVGWQVRKTCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQ 1178

Query: 1208 KKTIKIILEYADKIFTYIFILEMLLKWIAYGYKTYFTNAWCWLDFLIVDVSLVTLVANTL 1267
            K T+K +LEY D++FT+IF+ EMLLKW+AYG+K YFTNAWCWLDFLIV++SL++L A  L
Sbjct: 1179 KPTVKALLEYTDRVFTFIFVFEMLLKWVAYGFKKYFTNAWCWLDFLIVNISLISLTAKIL 1238

Query: 1268 GYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIM 1327
             YS++ PIK+LRTLRALRPLRALSRFEGMRVVV+AL+GAIPSIMNVLLVCLIFWLIFSIM
Sbjct: 1239 EYSEVAPIKALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIM 1298

Query: 1328 GVNLFAGKFYECINTTDG--SRFPASQVPNRSECFALMNVSQNVRWKNLKVNFDNVGLGY 1385
            GVNLFAGKF+ CIN TDG  S  P S V N+S+C  + N + +  W N+KVNFDNV +GY
Sbjct: 1299 GVNLFAGKFWRCINYTDGEFSLVPLSIVNNKSDC-KIQNSTGSFFWVNVKVNFDNVAMGY 1357

Query: 1386 LSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVI 1445
            L+LLQVATFKGW  IMYAAVDS  V+ QPK+E ++YMY+YFV+FIIFG FFTLNLF+GVI
Sbjct: 1358 LALLQVATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVI 1417

Query: 1446 IDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKIQGCIFDLVTNQA 1505
            IDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK QG +FD+VT QA
Sbjct: 1418 IDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKFQGFVFDIVTRQA 1477

Query: 1506 FDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTGECVLKLISLRHYYFTV 1565
            FDI+IMVLICLNM+TMMVE + QS+  T++L  IN  F+ +FTGECV+K+ +LR YYFT 
Sbjct: 1478 FDITIMVLICLNMITMMVETDDQSEEKTKILGKINQFFVAVFTGECVMKMFALRQYYFTN 1537

Query: 1566 GWNIFDFVVVIISIVGMFLADLIETY--FVSPTLFRVIRLARIGRILRLVKGAKGIRTLL 1623
            GWN+FDF+VV++SI  +  + ++++   + SPTLFRVIRLARIGRILRL++ AKGIRTLL
Sbjct: 1538 GWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRAAKGIRTLL 1597

Query: 1624 FALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEDGINDMFNFETFGNSMICLFQI 1683
            FALMMSLPALFNIGLLLFLVMFIY+IFGMS+F +V+ E GI+DMFNF+TF NSM+CLFQI
Sbjct: 1598 FALMMSLPALFNIGLLLFLVMFIYSIFGMSSFPHVRWEAGIDDMFNFQTFANSMLCLFQI 1657

Query: 1684 TTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNM 1743
            TTSAGWDGLL+PILN+ PP CDP  +   +   GDCG+P+VGI +F +YIIISFL++VNM
Sbjct: 1658 TTSAGWDGLLSPILNTGPPYCDP-NLPNSNGTRGDCGSPAVGIIFFTTYIIISFLIMVNM 1716

Query: 1744 YIAVILENFSVATEESTEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLL 1803
            YIAVILENF+VATEESTEPLSEDDF+MFYE WEKFDP+ATQFI FS LSDFA  L  PL 
Sbjct: 1717 YIAVILENFNVATEESTEPLSEDDFDMFYETWEKFDPEATQFITFSALSDFADTLSGPLR 1776

Query: 1804 IAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDSLRSQMEERFMSANPSK 1863
            I KPN+  LI MDLP+V GD+IHCLDILFAFTK VLGESGE+DSL++ MEE+FM+ N SK
Sbjct: 1777 IPKPNRNILIQMDLPLVPGDKIHCLDILFAFTKNVLGESGELDSLKANMEEKFMATNLSK 1836

Query: 1864 VSYEPITTTLKRKQEDVSATVIQRAYRRYRLRQNVKNISSIYIKDGDRDDDLLNKKDMAF 1923
             SYEPI TTL+ KQED+SATVIQ+AYR Y L +++   ++  +   + +   L  +    
Sbjct: 1837 SSYEPIATTLRWKQEDISATVIQKAYRSYVLHRSMALSNTPCVPRAEEEAASLPDEGFVA 1896

Query: 1924 DNVNENS-SPEKTDATSSTTSPPSYDSVTKPDKEKYEQDRTEKEDKGKDSKES 1975
               NEN   P+K++  S+T+ PPSY+SVT+   ++    RT    + +D   S
Sbjct: 1897 FTANENCVLPDKSETASATSFPPSYESVTRGLSDRVNM-RTSSSIQNEDEATS 1948


>gi|93587342 voltage-gated sodium channel type 4 alpha [Homo sapiens]
          Length = 1836

 Score = 1811 bits (4691), Expect = 0.0
 Identities = 915/1275 (71%), Positives = 1050/1275 (82%), Gaps = 26/1275 (2%)

Query: 676  QRAMSRASILTNTVEELEESRQKCPPWWYRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFV 735
            +++ S  S +++ +EELEE+ QKCPPWWY+ AHK LIWNC   W+KFK  I+ IVMDPFV
Sbjct: 521  RQSSSGDSGISDAMEELEEAHQKCPPWWYKCAHKVLIWNCCAPWLKFKNIIHLIVMDPFV 580

Query: 736  DLAITICIVLNTLFMAMEHHPMTEEFKNVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQV 795
            DL ITICIVLNTLFMAMEH+PMTE F NVL +GNLVFTGIF AEMVLKLIAMDPYEYFQ 
Sbjct: 581  DLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLIAMDPYEYFQQ 640

Query: 796  GWNIFDSLIVTLSLVELFLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGAL 855
            GWNIFDS+IVTLSLVEL LA+V+GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGAL
Sbjct: 641  GWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGAL 700

Query: 856  GNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCG 915
            GNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKI  DC LPRWHM+DFFHSFLIVFR+LCG
Sbjct: 701  GNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIALDCNLPRWHMHDFFHSFLIVFRILCG 760

Query: 916  EWIETMWDCMEVAGQAMCLIVYMMVMVIGNLVVLNLFLALLLSSFSSDNLTAIEEDPDAN 975
            EWIETMWDCMEVAGQAMCL V++MVMVIGNLVVLNLFLALLLSSFS+D+L A +ED + N
Sbjct: 761  EWIETMWDCMEVAGQAMCLTVFLMVMVIGNLVVLNLFLALLLSSFSADSLAASDEDGEMN 820

Query: 976  NLQIAVTRIKKGINYVKQTLREFILKAFSKKPKISREIRQAEDLN-------TKKENYIS 1028
            NLQIA+ RIK GI + K  L   +         I   + +A+          T  E+   
Sbjct: 821  NLQIAIGRIKLGIGFAKAFLLGLLHGKILSPKDIMLSLGEADGAGEAGEAGETAPEDEKK 880

Query: 1029 NHTLAEMSKGHNFLKEKDKISGFGSSVDKHLMEDSDGQSFIHNPSLTVTVPIAPGESDLE 1088
                 ++ K ++ L       G  SS++       D  +FI+NP LT+ VPIA  ESDLE
Sbjct: 881  EPPEEDLKKDNHILNHMGLADGPPSSLEL------DHLNFINNPYLTIQVPIASEESDLE 934

Query: 1089 NMNAEELSSDSDSEYSKVR---LNRSSSSECSTVDNPLPGEGEEAEAEPM-NSDEPEACF 1144
                EE  + S+ E SK     L   +SS CST D   P E  E +AE     ++PE CF
Sbjct: 935  MPTEEETDTFSEPEDSKKPPQPLYDGNSSVCSTADYKPPEEDPEEQAEENPEGEQPEECF 994

Query: 1145 TDGCVRRFSCCQVNIESGKGKIWWNIRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIY 1204
            T+ CV+R+ C  V+I  G+GK WW +R+ C+KIVEH+WFE+FIV MILLSSGALAFEDIY
Sbjct: 995  TEACVQRWPCLYVDISQGRGKKWWTLRRACFKIVEHNWFETFIVFMILLSSGALAFEDIY 1054

Query: 1205 IERKKTIKIILEYADKIFTYIFILEMLLKWIAYGYKTYFTNAWCWLDFLIVDVSLVTLVA 1264
            IE+++ I+ ILEYADK+FTYIFI+EMLLKW+AYG+K YFTNAWCWLDFLIVDVS+++LVA
Sbjct: 1055 IEQRRVIRTILEYADKVFTYIFIMEMLLKWVAYGFKVYFTNAWCWLDFLIVDVSIISLVA 1114

Query: 1265 NTLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIF 1324
            N LGYS+LGPIKSLRTLRALRPLRALSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIF
Sbjct: 1115 NWLGYSELGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIF 1174

Query: 1325 SIMGVNLFAGKFYECINTTDGSRFPASQVPNRSECFALMNVSQNVRWKNLKVNFDNVGLG 1384
            SIMGVNLFAGKFY CINTT   RF  S+V N+SEC +LM+  Q VRW N+KVN+DNVGLG
Sbjct: 1175 SIMGVNLFAGKFYYCINTTTSERFDISEVNNKSECESLMHTGQ-VRWLNVKVNYDNVGLG 1233

Query: 1385 YLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGV 1444
            YLSLLQVATFKGW  IMYAAVDS   ++QP+YE +LYMY+YFV+FIIFGSFFTLNLFIGV
Sbjct: 1234 YLSLLQVATFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIGV 1293

Query: 1445 IIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKIQGCIFDLVTNQ 1504
            IIDNFNQQKKKLGG+DIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NKIQG ++DLVT Q
Sbjct: 1294 IIDNFNQQKKKLGGKDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQGMVYDLVTKQ 1353

Query: 1505 AFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTGECVLKLISLRHYYFT 1564
            AFDI+IM+LICLNMVTMMVE + QSQ   ++LY IN++FII+FTGECVLK+++LR YYFT
Sbjct: 1354 AFDITIMILICLNMVTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLKMLALRQYYFT 1413

Query: 1565 VGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRLARIGRILRLVKGAKGIRTLLF 1624
            VGWNIFDFVVVI+SIVG+ L+DLI+ YFVSPTLFRVIRLARIGR+LRL++GAKGIRTLLF
Sbjct: 1414 VGWNIFDFVVVILSIVGLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLF 1473

Query: 1625 ALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEDGINDMFNFETFGNSMICLFQIT 1684
            ALMMSLPALFNIGLLLFLVMFIY+IFGMSNFAYVKKE GI+DMFNFETFGNS+ICLF+IT
Sbjct: 1474 ALMMSLPALFNIGLLLFLVMFIYSIFGMSNFAYVKKESGIDDMFNFETFGNSIICLFEIT 1533

Query: 1685 TSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMY 1744
            TSAGWDGLL PILNS PPDCDP   +PG+SV+GDCGNPS+GI +F SYIIISFL+VVNMY
Sbjct: 1534 TSAGWDGLLNPILNSGPPDCDPNLENPGTSVKGDCGNPSIGICFFCSYIIISFLIVVNMY 1593

Query: 1745 IAVILENFSVATEESTEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLI 1804
            IA+ILENF+VATEES+EPL EDDFEMFYE WEKFDPDATQFI +S+LSDF   L  PL I
Sbjct: 1594 IAIILENFNVATEESSEPLGEDDFEMFYETWEKFDPDATQFIAYSRLSDFVDTLQEPLRI 1653

Query: 1805 AKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDSLRSQMEERFMSANPSKV 1864
            AKPNK++LI +DLPMV GD+IHCLDILFA TK VLG+SGEMD+L+  MEE+FM+ANPSKV
Sbjct: 1654 AKPNKIKLITLDLPMVPGDKIHCLDILFALTKEVLGDSGEMDALKQTMEEKFMAANPSKV 1713

Query: 1865 SYEPITTTLKRKQEDVSATVIQRAYRRYRLRQNVKNISSIY--IKDGDRDDD------LL 1916
            SYEPITTTLKRK E+V A  IQRAYRR+ L++++K  S +Y    DG  DD       L 
Sbjct: 1714 SYEPITTTLKRKHEEVCAIKIQRAYRRHLLQRSMKQASYMYRHSHDGSGDDAPEKEGLLA 1773

Query: 1917 NKKDMAFDNVNENSS 1931
            N     + + N NSS
Sbjct: 1774 NTMSKMYGHENGNSS 1788



 Score =  630 bits (1624), Expect = e-180
 Identities = 322/485 (66%), Positives = 376/485 (77%), Gaps = 40/485 (8%)

Query: 1   MAMLPPPGPQSFVHFTKQSLALIEQRIAERKSKEPKEEKKDDDEEAPKPSSDLEAGKQLP 60
           +  L P GP+    FT++SLA IEQR  E +++  + ++ + +E   KP SDLEAGK LP
Sbjct: 6   LCTLVPLGPECLRPFTRESLAAIEQRAVEEEARLQRNKQMEIEEPERKPRSDLEAGKNLP 65

Query: 61  FIYGDIPPGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRISI 120
            IYGD PP ++  PLEDLDPYY++KKTFIVLNKGK IFRF+ATPALY+LSPFS +RR +I
Sbjct: 66  MIYGDPPPEVIGIPLEDLDPYYSNKKTFIVLNKGKAIFRFSATPALYLLSPFSVVRRGAI 125

Query: 121 KILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKILARGFCVGE 180
           K+L+H+LFSM IM TILTNC+FMTM++PP W+KNVEYTFTGIYTFESL+KILARGFCV +
Sbjct: 126 KVLIHALFSMFIMITILTNCVFMTMSDPPPWSKNVEYTFTGIYTFESLIKILARGFCVDD 185

Query: 181 FTFLRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQ 240
           FTFLRDPWNWLDF VI+ AYLTEFV+LGN+SALRTFRVLRALKTI+VIPGLKTIVGALIQ
Sbjct: 186 FTFLRDPWNWLDFSVIMMAYLTEFVDLGNISALRTFRVLRALKTITVIPGLKTIVGALIQ 245

Query: 241 SVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFR----------------------- 277
           SVKKLSDVMILTVFCLSVFAL+GLQLFMGNL+ KC R                       
Sbjct: 246 SVKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPFNDTNTTWYSNDTWYGNDT 305

Query: 278 ----------NSLENNETLESIMNTLESEE-DFRKY------FYYLEGSKDALLCGFSTD 320
                     +S   N+T  S  +   ++  D+  Y      FY+LEGS DALLCG S+D
Sbjct: 306 WYGNEMWYGNDSWYANDTWNSHASWATNDTFDWDAYISDEGNFYFLEGSNDALLCGNSSD 365

Query: 321 SGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYMI 380
           +G CPEGY C+K GRNP+YGYTS+DTFSWAFLALFRLMTQDYWENL+Q TLRAAGKTYMI
Sbjct: 366 AGHCPEGYECIKTGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMI 425

Query: 381 FFVVVIFLGSFYLINLILAVVAMAYEEQNQANIEEAKQKELEFQQMLDRLKKEQEEAEAI 440
           FFVV+IFLGSFYLINLILAVVAMAY EQN+A + E K+KE EFQQML++ KK QEE E  
Sbjct: 426 FFVVIIFLGSFYLINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKKHQEELEKA 485

Query: 441 AAAAA 445
            AA A
Sbjct: 486 KAAQA 490



 Score = 88.2 bits (217), Expect = 7e-17
 Identities = 101/442 (22%), Positives = 179/442 (40%), Gaps = 78/442 (17%)

Query: 6    PPGPQSFVH--FTKQSLALIEQRIAERKS--KEPKEEKKD---DDEEAPKPSSDLEAGKQ 58
            PP      H  F       I+  IA  +S  + P EE+ D   + E++ KP   L  G  
Sbjct: 903  PPSSLELDHLNFINNPYLTIQVPIASEESDLEMPTEEETDTFSEPEDSKKPPQPLYDGNS 962

Query: 59   LPFIYGDIPPGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYML------SPF 112
                  D  P     P ED +    +        +  T       P LY+         +
Sbjct: 963  SVCSTADYKP-----PEEDPEEQAEENPEGEQPEECFTEACVQRWPCLYVDISQGRGKKW 1017

Query: 113  SPLRRISIKILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNV-----EYT---FTGIYT 164
              LRR   KI+ H+ F   I+  IL +   +   +     + V     EY    FT I+ 
Sbjct: 1018 WTLRRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFI 1077

Query: 165  FESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVN------LGNVSALRTFRV 218
             E L+K +A GF V    +  + W WLDF+++  + ++   N      LG + +LRT R 
Sbjct: 1078 MEMLLKWVAYGFKV----YFTNAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRA 1133

Query: 219  LRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRN 278
            LR L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G   + C   
Sbjct: 1134 LRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-YYCINT 1192

Query: 279  SLENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPD 338
            +      +  + N  E                    C     +GQ    +  VK+     
Sbjct: 1193 TTSERFDISEVNNKSE--------------------CESLMHTGQV--RWLNVKV----- 1225

Query: 339  YGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGK---------TYM-IFFVVVIFL 388
                ++D     +L+L ++ T   W ++    + +  K          YM ++FV+ I  
Sbjct: 1226 ----NYDNVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIF 1281

Query: 389  GSFYLINLILAVVAMAYEEQNQ 410
            GSF+ +NL + V+   + +Q +
Sbjct: 1282 GSFFTLNLFIGVIIDNFNQQKK 1303



 Score = 80.1 bits (196), Expect = 2e-14
 Identities = 49/169 (28%), Positives = 91/169 (53%), Gaps = 18/169 (10%)

Query: 1170 IRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILE 1229
            +R+   K++ H+ F  FI++ IL +   +   D     K      +EY    FT I+  E
Sbjct: 120  VRRGAIKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKN-----VEYT---FTGIYTFE 171

Query: 1230 MLLKWIAYGYK----TYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALR 1285
             L+K +A G+     T+  + W WLDF ++ ++ +T       + DLG I +LRT R LR
Sbjct: 172  SLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLT------EFVDLGNISALRTFRVLR 225

Query: 1286 PLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1334
             L+ ++   G++ +V ALI ++  + +V+++ +    +F+++G+ LF G
Sbjct: 226  ALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMG 274



 Score = 75.9 bits (185), Expect = 4e-13
 Identities = 59/209 (28%), Positives = 106/209 (50%), Gaps = 18/209 (8%)

Query: 704 YRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKN 763
           +RF+    ++  SP+ +  +  I  ++   F  + I I I+ N +FM M   P     KN
Sbjct: 103 FRFSATPALYLLSPFSVVRRGAIKVLIHALF-SMFIMITILTNCVFMTMSDPPPWS--KN 159

Query: 764 VLAIGNLVFTGIFAAEMVLKLIA----MDPYEYFQVGWNIFDSLIVTLSLVELFLADVEG 819
           V       FTGI+  E ++K++A    +D + + +  WN  D  ++ ++ +  F+ D+  
Sbjct: 160 V----EYTFTGIYTFESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLTEFV-DLGN 214

Query: 820 LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-G 878
           +S LR+FR+LR  K     P L  ++  +  SV  L ++ ++    + +FA+VG+QLF G
Sbjct: 215 ISALRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMG 274

Query: 879 KSYKECV---CKINDDCTLPRWHMNDFFH 904
              ++CV      ND  T   W+ ND ++
Sbjct: 275 NLRQKCVRWPPPFND--TNTTWYSNDTWY 301



 Score = 67.8 bits (164), Expect = 1e-10
 Identities = 46/181 (25%), Positives = 90/181 (49%), Gaps = 11/181 (6%)

Query: 110 SPFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTMNNPP--DWTKNV----EYTFTGIY 163
           +P+   + I   I++     + I   I+ N +FM M + P  +   NV       FTGI+
Sbjct: 562 APWLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIF 621

Query: 164 TFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLT-EFVNLGNVSALRTFRVLRAL 222
           T E ++K++A    +  + + +  WN  D +++  + +     N+  +S LR+FR+LR  
Sbjct: 622 TAEMVLKLIA----MDPYEYFQQGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVF 677

Query: 223 KTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLEN 282
           K     P L  ++  +  SV  L ++ ++    + +FA++G+QLF  + K    + +L+ 
Sbjct: 678 KLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIALDC 737

Query: 283 N 283
           N
Sbjct: 738 N 738



 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 54/206 (26%), Positives = 89/206 (43%), Gaps = 40/206 (19%)

Query: 94   GKTIFR-------FNATPALYMLSPFSPLRRISIKI--LVHSL-----FSMLIMCTILTN 139
            GK IF        +NA   L    P  P+ R   KI  +V+ L     F + IM  I  N
Sbjct: 1307 GKDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQGMVYDLVTKQAFDITIMILICLN 1366

Query: 140  CIFMTMNNPP------DWTKNVEYTFTGIYTFESLVKILARG---FCVGEFTFLRDPWNW 190
             + M +          D   N+   F  I+T E ++K+LA     F VG        WN 
Sbjct: 1367 MVTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLKMLALRQYYFTVG--------WNI 1418

Query: 191  LDFVVIVFAYL---------TEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQS 241
             DFVV++ + +           FV+      +R  R+ R L+ I    G++T++ AL+ S
Sbjct: 1419 FDFVVVILSIVGLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMS 1478

Query: 242  VKKLSDVMILTVFCLSVFALIGLQLF 267
            +  L ++ +L    + ++++ G+  F
Sbjct: 1479 LPALFNIGLLLFLVMFIYSIFGMSNF 1504



 Score = 50.1 bits (118), Expect = 2e-05
 Identities = 103/517 (19%), Positives = 197/517 (38%), Gaps = 123/517 (23%)

Query: 1334 GKFYECINTTD----GSRFPASQVPNRSECFALMNVSQNVRWKNLKVNFDNVGLGYLSLL 1389
            G FY    + D    G+   A   P   EC   +   +N  +     ++D     +L+L 
Sbjct: 346  GNFYFLEGSNDALLCGNSSDAGHCPEGYEC---IKTGRNPNYGY--TSYDTFSWAFLALF 400

Query: 1390 QVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNF 1449
            ++ T   W  +    + +             YM I+FVV I  GSF+ +NL + V+   +
Sbjct: 401  RLMTQDYWENLFQLTLRAAG---------KTYM-IFFVVIIFLGSFYLINLILAVVAMAY 450

Query: 1450 NQQKKKLGGQD-------IFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKIQG--CIFDL 1500
             +Q +    +D         M E+ KK+   ++K  + +  +     G+   G  C   L
Sbjct: 451  AEQNEATLAEDKEKEEEFQQMLEKFKKHQEELEKAKAAQALEGGEADGDPAHGKDCNGSL 510

Query: 1501 VTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTGEC--------V 1552
             T+Q    +       +       +E +  H     +W      +L    C        +
Sbjct: 511  DTSQGEKGAPRQSSSGDSGISDAMEELEEAHQKCPPWWYKCAHKVLIWNCCAPWLKFKNI 570

Query: 1553 LKLI---------------------SLRHYYFTVGWNIFDFVVVIISIV--GMFLADLI- 1588
            + LI                     ++ HY  T     FD V+ + ++V  G+F A+++ 
Sbjct: 571  IHLIVMDPFVDLGITICIVLNTLFMAMEHYPMT---EHFDNVLTVGNLVFTGIFTAEMVL 627

Query: 1589 ------------ETYFVSPTLFRVIRLARIG-------------RILRLVKGAKGIRTLL 1623
                        + + +  ++   + L  +G             R+LR+ K AK   TL 
Sbjct: 628  KLIAMDPYEYFQQGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSWPTLN 687

Query: 1624 FALMM---SLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKE-------DGINDMFNFETF 1673
              + +   S+ AL N+ L+L +++FI+A+ GM  F    KE       D     ++   F
Sbjct: 688  MLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIALDCNLPRWHMHDF 747

Query: 1674 GNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYI 1733
             +S + +F+I      + +          DC             +    ++ +  F+  +
Sbjct: 748  FHSFLIVFRILCGEWIETMW---------DC------------MEVAGQAMCLTVFLMVM 786

Query: 1734 IISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEM 1770
            +I  LVV+N+++A++L +FS      +   S++D EM
Sbjct: 787  VIGNLVVLNLFLALLLSSFSA----DSLAASDEDGEM 819



 Score = 37.7 bits (86), Expect = 0.11
 Identities = 16/72 (22%), Positives = 41/72 (56%)

Query: 902 FFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVYMMVMVIGNLVVLNLFLALLLSSFS 961
           F  +FL +FR++  ++ E ++     A     +I +++++ +G+  ++NL LA++  +++
Sbjct: 392 FSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVAMAYA 451

Query: 962 SDNLTAIEEDPD 973
             N   + ED +
Sbjct: 452 EQNEATLAEDKE 463


>gi|111378393 sodium channel, voltage-gated, type VII, alpha [Homo
            sapiens]
          Length = 1682

 Score = 1403 bits (3632), Expect = 0.0
 Identities = 720/1293 (55%), Positives = 940/1293 (72%), Gaps = 39/1293 (3%)

Query: 639  LPNGQLLPEGTTNQIHKKRRCS-SYLLSEDMLNDPNLRQRAMSRASILTNTVEELEESRQ 697
            L  G    E  T QI  K+R   S   S D+L D  LR +            EELE+S++
Sbjct: 422  LQEGNETDEAKTIQIEMKKRSPISTDTSLDVLEDATLRHK------------EELEKSKK 469

Query: 698  KCPPWWYRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPM 757
             CP +WY+FA  FLIWNCSP W+K K+ ++ I+M PF DL + ICI+LN  F+ +EH+PM
Sbjct: 470  ICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNVCFLTLEHYPM 529

Query: 758  TEEFKNVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADV 817
            +++   +L IGNLVF GIF AEM+ K+IAM PY YFQVGWNIFDS+IV   L+EL LA+V
Sbjct: 530  SKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFHGLIELCLANV 589

Query: 818  EGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 877
             G+++LR FR+LR+FKL K WPT  +L+  + NS  AL +L L+L   +F  A  GM+LF
Sbjct: 590  AGMALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLF 649

Query: 878  GKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVY 937
            GK+Y+E VC I+ DC LPRWHM+DFFHSFL VFR+LCGEW+ET+WDCMEVAGQ+ C+  Y
Sbjct: 650  GKNYEEFVCHIDKDCQLPRWHMHDFFHSFLNVFRILCGEWVETLWDCMEVAGQSWCIPFY 709

Query: 938  MMVMVIGNLVVLNLFLALLLSSFSSDNLTAIEEDPDANNLQIAVTRIKKGINYVKQTLRE 997
            +MV++IGNL+VL LFLAL+ SSFSS      EE+ +A NLQ+AV RIKKGINYV      
Sbjct: 710  LMVILIGNLLVLYLFLALV-SSFSSCKDVTAEENNEAKNLQLAVARIKKGINYV------ 762

Query: 998  FILKAFSKKPKISREIRQAEDLNTKKENYISNHTLAEMSKGHNFLKEKDKISGFGSSVDK 1057
             +LK   K   + ++     +    KE+ IS+HTL+E+S   +FLK+K+K SG     +K
Sbjct: 763  -LLKILCKTQNVPKDTMDHVNEVYVKED-ISDHTLSELSNTQDFLKDKEKSSG----TEK 816

Query: 1058 HLMEDSDGQSFIHNPSLTVTVPIAPGESDLENMNAEELSSDSDSEYSKVRLNRSSSSECS 1117
            +  E+ + QS I +PS++ TVPIA GESD+EN++ +E+ S S    SK ++ +SSSSECS
Sbjct: 817  NATEN-ESQSLIPSPSVSETVPIASGESDIENLDNKEIQSKSGDGGSKEKIKQSSSSECS 875

Query: 1118 TVDNPLPGEGEEAEAEPMNSDEPEACFTDGCVRRFSCCQVNIESGKGKIWWNIRKTCYKI 1177
            TVD  +       E E     E      +GC R  S  Q++  S KGKIW NIRKTC KI
Sbjct: 876  TVDIAI-----SEEEEMFYGGERSKHLKNGCRRGSSLGQISGASKKGKIWQNIRKTCCKI 930

Query: 1178 VEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILEMLLKWIAY 1237
            VE++WF+ FI L+ LLS+G LAFEDIY++++KTIKI+LEYAD IFTYIFILEMLLKW+AY
Sbjct: 931  VENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILEMLLKWMAY 990

Query: 1238 GYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSRFEGMR 1297
            G+K YF+N W  LDF++V V  ++L+  T        +K L +++ LRPLR LS+FE M+
Sbjct: 991  GFKAYFSNGWYRLDFVVVIVFCLSLIGKTRE-----ELKPLISMKFLRPLRVLSQFERMK 1045

Query: 1298 VVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDGSRFPASQVPNRS 1357
            VVV ALI      +NV LVCL+ WLIFSIMGV+LFAG+FYECI+ T G RFP+S+V N+S
Sbjct: 1046 VVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPTSGERFPSSEVMNKS 1105

Query: 1358 ECFALMNVSQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYE 1417
             C +L+  ++++ W+N K+NFDNVG G+LSLLQVATF GW  IM +A+DSV V+ QP +E
Sbjct: 1106 RCESLL-FNESMLWENAKMNFDNVGNGFLSLLQVATFNGWITIMNSAIDSVAVNIQPHFE 1164

Query: 1418 YSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKL 1477
             ++YMY YF+ FIIFG F  L++ I VIIDNFN+ K KLGG +IF+T +Q+K Y  +KKL
Sbjct: 1165 VNIYMYCYFINFIIFGVFLPLSMLITVIIDNFNKHKIKLGGSNIFITVKQRKQYRRLKKL 1224

Query: 1478 GSKKPQKPIPRPGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLY 1537
              +  Q+P+PRP NK+QG IFD+VT+QAF++ +MVLIC   + MM++ + QS  M+  LY
Sbjct: 1225 MYEDSQRPVPRPLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIALY 1284

Query: 1538 WINVVFIILFTGECVLKLISLRHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTL 1597
            WIN +F++L+T EC+LKLI+ R +YFT+ WNIFDF+VVI SI G+ L   + +Y V P+L
Sbjct: 1285 WINSIFVMLYTMECILKLIAFRCFYFTIAWNIFDFMVVIFSITGLCLPMTVGSYLVPPSL 1344

Query: 1598 FRVIRLARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAY 1657
             ++I L+RI  +LRL KG K    L+  LM+SLPAL NI LL+FLVMFIYA+FGM NFAY
Sbjct: 1345 VQLILLSRIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNFAY 1404

Query: 1658 VKKEDGINDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEG 1717
            VKKE GIND+ NFETFGNSM+CLFQ+   AGWDG+L  I NSK  DCDP K++PG+ V G
Sbjct: 1405 VKKEAGINDVSNFETFGNSMLCLFQVAIFAGWDGMLDAIFNSKWSDCDPDKINPGTQVRG 1464

Query: 1718 DCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWEK 1777
            DCGNPSVGIFYFVSYI+IS+L++VNMYI V++E  ++A+++  + LSEDDF  F++VW++
Sbjct: 1465 DCGNPSVGIFYFVSYILISWLIIVNMYIVVVMEFLNIASKKKNKTLSEDDFRKFFQVWKR 1524

Query: 1778 FDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKR 1837
            FDPD TQ+I+ SKLSDFAAALDPPL +AKPNK QLIA+DLPM  GDRIHCLDIL AFTKR
Sbjct: 1525 FDPDRTQYIDSSKLSDFAAALDPPLFMAKPNKGQLIALDLPMAVGDRIHCLDILLAFTKR 1584

Query: 1838 VLGESGEMDSLRSQMEERFMSANPSKVSYEPITTTLKRKQEDVSATVIQRAYRRYRLRQN 1897
            V+G+   M+ + S++E  F+ ANP K++ EPITTTLKRKQE VSAT+IQRAY+ YRLR+N
Sbjct: 1585 VMGQDVRMEKVVSEIESGFLLANPFKITCEPITTTLKRKQEAVSATIIQRAYKNYRLRRN 1644

Query: 1898 VKNISSIYIKDGDRDDDLLNKKDMAFDNVNENS 1930
             KN S I++ DGDRD     K+   FD   E S
Sbjct: 1645 DKNTSDIHMIDGDRDVH-ATKEGAYFDKAKEKS 1676



 Score =  449 bits (1154), Expect = e-125
 Identities = 247/478 (51%), Positives = 316/478 (66%), Gaps = 14/478 (2%)

Query: 3   MLPPPGPQSFVHFTKQSLALIEQRIAERKSKEPKEEKKDDDEEAPKPSSDLEAGKQLPFI 62
           ML  P P+  V FTK+S  LI+Q IA       K   +D +EE  KP+ DLE GK+LPFI
Sbjct: 1   MLASPEPKGLVPFTKESFELIKQHIA-------KTHNEDHEEEDLKPTPDLEVGKKLPFI 53

Query: 63  YGDIPPGMVSEPLEDLDPYYADKK-TFIVLNKGKTIFRFNATPALYMLSPFSPLRRISIK 121
           YG++  GMVSEPLED+DPYY  KK TFIVLNK +TIFRFNA   L  LSPF+ +RR +IK
Sbjct: 54  YGNLSQGMVSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLSPFNCIRRTTIK 113

Query: 122 ILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKILARGFCVGEF 181
           +LVH  F + I+ ++L +C+FM++ N P W   +E T  GIYTFE LVK+ ARG   G F
Sbjct: 114 VLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENTLLGIYTFEILVKLFARGVWAGSF 173

Query: 182 TFLRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQS 241
           +FL DPWNWLDF V VF  +  +  L  +  L+T R LR LK I +  GLK++VG LI  
Sbjct: 174 SFLGDPWNWLDFSVTVFEVIIRYSPLDFIPTLQTARTLRILKIIPLNQGLKSLVGVLIHC 233

Query: 242 VKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLEN-NETLES-IMNTLESEEDF 299
           +K+L  V+ILT+F LS+F+LIG+ LFMGNLKHKCFR   EN NETL +   N     E  
Sbjct: 234 LKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENENETLHNRTGNPYYIRE-- 291

Query: 300 RKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLALFRLMT 359
            + FYYLEG + ALLCG  TD+GQCPEGY CVK G NPD G+T+FD+F WA  ALFRLM 
Sbjct: 292 TENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQGFTNFDSFGWALFALFRLMA 351

Query: 360 QDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANIEEAKQK 419
           QDY E LY Q L A+GK YMIFFVVV FL SFY+ +L L ++AMAYEE+ Q   E +K+ 
Sbjct: 352 QDYPEVLYHQILYASGKVYMIFFVVVSFLFSFYMASLFLGILAMAYEEEKQRVGEISKKI 411

Query: 420 ELEFQQMLDRLKK--EQEEAEAIAAAAAEYTSIRRSRIMGLSESSSETSKLSSKSAKE 475
           E +FQQ    L++  E +EA+ I     + + I     + + E ++   K   + +K+
Sbjct: 412 EPKFQQTGKELQEGNETDEAKTIQIEMKKRSPISTDTSLDVLEDATLRHKEELEKSKK 469



 Score =  135 bits (341), Expect = 3e-31
 Identities = 140/577 (24%), Positives = 249/577 (43%), Gaps = 125/577 (21%)

Query: 1170 IRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILE 1229
            IR+T  K++ H +F+ FI++ +L+    ++  ++   R      +L     I+T+  +++
Sbjct: 107  IRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENTLLG----IYTFEILVK 162

Query: 1230 MLLKWIAYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRA 1289
            +  + +  G  ++  + W WLDF       VT+    + YS L  I +L+T R LR L+ 
Sbjct: 163  LFARGVWAGSFSFLGDPWNWLDFS------VTVFEVIIRYSPLDFIPTLQTARTLRILKI 216

Query: 1290 LSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-YEC--------- 1339
            +   +G++ +V  LI  +  ++ V+++ L F  IFS++G+ LF G   ++C         
Sbjct: 217  IPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENEN 276

Query: 1340 ------------INTTD--------------GSRFPASQVPNRSECF-ALMNVSQNVRWK 1372
                        I  T+              G+R  A Q P    C  A +N  Q     
Sbjct: 277  ETLHNRTGNPYYIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQGF--- 333

Query: 1373 NLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIF 1432
                NFD+ G    +L ++   + +  ++Y          Q  Y       I+FVV    
Sbjct: 334  ---TNFDSFGWALFALFRLMA-QDYPEVLY---------HQILYASGKVYMIFFVVVSFL 380

Query: 1433 GSFFTLNLFIGVIIDNFNQQKKKLGG----------------QDIFMTEEQKKYYNAMKK 1476
             SF+  +LF+G++   + ++K+++G                 Q+   T+E K     MKK
Sbjct: 381  FSFYMASLFLGILAMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEAKTIQIEMKK 440

Query: 1477 LGS---------------------KKPQKPIPRPGNK------IQGC----------IFD 1499
                                    +K +K  P    K      I  C          +  
Sbjct: 441  RSPISTDTSLDVLEDATLRHKEELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHR 500

Query: 1500 LVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTGECVLKLISLR 1559
            ++     D+ +++ I LN+  + +E    S+    +L   N+VFI +FT E + K+I++ 
Sbjct: 501  IIMAPFTDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMH 560

Query: 1560 HY-YFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRLARIGRILRLVKGAKG 1618
             Y YF VGWNIFD ++V   ++ + LA++            ++RL R+ RI +L K    
Sbjct: 561  PYGYFQVGWNIFDSMIVFHGLIELCLANVAG--------MALLRLFRMLRIFKLGKYWPT 612

Query: 1619 IRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNF 1655
             + L+++L  S  AL ++ LLLF  +F  A FGM  F
Sbjct: 613  FQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLF 649



 Score = 58.2 bits (139), Expect = 8e-08
 Identities = 107/502 (21%), Positives = 208/502 (41%), Gaps = 92/502 (18%)

Query: 17  KQSLALIEQRIAERKSKEPKEEKKDDDEEAPKPSSDLEAGKQLPFIYGDIPPGMVSEPLE 76
           KQ +  I ++I E K ++  +E ++ +E     +  +E  K+ P     I      + LE
Sbjct: 401 KQRVGEISKKI-EPKFQQTGKELQEGNETDEAKTIQIEMKKRSP-----ISTDTSLDVLE 454

Query: 77  DLDPYYADKKTFIVLNKGKTI-----FRFNATPALYMLSP-FSPLRRISIKILVHSLFSM 130
           D    + ++     L K K I     ++F  T  ++  SP +  L+    +I++     +
Sbjct: 455 DATLRHKEE-----LEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDL 509

Query: 131 LIMCTILTNCIFMTMNNPP-----DWTKNV-EYTFTGIYTFESLVKILARGFCVGEFTFL 184
            ++  I+ N  F+T+ + P     +   N+    F GI+T E + KI+A    +  + + 
Sbjct: 510 FLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIA----MHPYGYF 565

Query: 185 RDPWNWLDFVVIVFAYLTE--FVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSV 242
           +  WN  D  +IVF  L E    N+  ++ LR FR+LR  K     P  + ++ +L  S 
Sbjct: 566 QVGWNIFD-SMIVFHGLIELCLANVAGMALLRLFRMLRIFKLGKYWPTFQILMWSLSNSW 624

Query: 243 KKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETLESIMNTLESEEDFRKY 302
             L D+++L    +   A  G++LF  N                          E+F   
Sbjct: 625 VALKDLVLLLFTFIFFSAAFGMKLFGKNY-------------------------EEF--- 656

Query: 303 FYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQDY 362
                      +C    D  Q P  +         D+ ++  + F        R++  ++
Sbjct: 657 -----------VCHIDKDC-QLPRWHM-------HDFFHSFLNVF--------RILCGEW 689

Query: 363 WENLYQQTLRAAGKTYMI-FFVVVIFLGSFYLINLILAVVAMAYEEQNQANIEEAKQKEL 421
            E L+   +  AG+++ I F+++VI +G+  ++ L LA+V+ ++        EE  + + 
Sbjct: 690 VETLW-DCMEVAGQSWCIPFYLMVILIGNLLVLYLFLALVS-SFSSCKDVTAEENNEAK- 746

Query: 422 EFQQMLDRLKKEQEEAEAIAAAAAEYTSIRRSRIMGLSESSSETSKLSSKSAKERRNRRK 481
             Q  + R+KK       +     +  ++ +  +  ++E   +   +S  +  E  N + 
Sbjct: 747 NLQLAVARIKKGIN--YVLLKILCKTQNVPKDTMDHVNEVYVK-EDISDHTLSELSNTQD 803

Query: 482 KKNQKKLSSGEEKGDAEKLSKS 503
               K+ SSG EK   E  S+S
Sbjct: 804 FLKDKEKSSGTEKNATENESQS 825



 Score = 51.6 bits (122), Expect = 8e-06
 Identities = 63/295 (21%), Positives = 115/295 (38%), Gaps = 45/295 (15%)

Query: 115  LRRISIKILVHSLFSMLI-MCTILTNCIFMTMNNPPDWTKNV----EYT---FTGIYTFE 166
            +R+   KI+ ++ F   I + T+L+       +   D  K +    EY    FT I+  E
Sbjct: 923  IRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILE 982

Query: 167  SLVKILARGFCVGEFTFLRDPWNWLDFVV-IVFAYLTEFVNLGNVSALRTFRVLRALKTI 225
             L+K +A GF      +  + W  LDFVV IVF           +  L + + LR L+ +
Sbjct: 983  MLLKWMAYGFKA----YFSNGWYRLDFVVVIVFCLSLIGKTREELKPLISMKFLRPLRVL 1038

Query: 226  SVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNET 285
            S    +K +V ALI++     +V ++ +    +F+++G+ LF G   ++C   +      
Sbjct: 1039 SQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRF-YECIDPTSGERFP 1097

Query: 286  LESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFD 345
               +MN    E          E +K                                +FD
Sbjct: 1098 SSEVMNKSRCESLLFNESMLWENAK-------------------------------MNFD 1126

Query: 346  TFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAV 400
                 FL+L ++ T + W  +    + +        F V I++  +++  +I  V
Sbjct: 1127 NVGNGFLSLLQVATFNGWITIMNSAIDSVAVNIQPHFEVNIYMYCYFINFIIFGV 1181



 Score = 47.8 bits (112), Expect = 1e-04
 Identities = 44/205 (21%), Positives = 96/205 (46%), Gaps = 26/205 (12%)

Query: 692 LEESRQKCPPWWYRFAHKFLIWNCSPYWIKFK-----------KCI----YFIVMDPFVD 736
           + E  +   P++Y+  + F++ N +    +F             CI      +++ PF  
Sbjct: 62  VSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLSPFNCIRRTTIKVLVHPFFQ 121

Query: 737 LAITICIVLNTLFMAMEHHPMTEEFKNVLAIGNLVFTGIFAAEMVLKLIAMD----PYEY 792
           L I I ++++ +FM++ + P   +++ VL        GI+  E+++KL A       + +
Sbjct: 122 LFILISVLIDCVFMSLTNLP---KWRPVL---ENTLLGIYTFEILVKLFARGVWAGSFSF 175

Query: 793 FQVGWNIFDSLIVTLSLVELFLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSV 852
               WN  D   VT+  V +  + ++ +  L++ R LR+ K+      L  L+ ++ + +
Sbjct: 176 LGDPWNWLD-FSVTVFEVIIRYSPLDFIPTLQTARTLRILKIIPLNQGLKSLVGVLIHCL 234

Query: 853 GALGNLTLVLAIIVFIFAVVGMQLF 877
             L  + ++    + IF+++GM LF
Sbjct: 235 KQLIGVIILTLFFLSIFSLIGMGLF 259



 Score = 38.5 bits (88), Expect = 0.066
 Identities = 42/198 (21%), Positives = 87/198 (43%), Gaps = 27/198 (13%)

Query: 111  PFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTMNNPPD---------WTKNVEYTFTG 161
            P + L+     ++    F++++M  I    I M ++             W  ++   F  
Sbjct: 1236 PLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIALYWINSI---FVM 1292

Query: 162  IYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAY------LTEFVNLGNVSALRT 215
            +YT E ++K++A  F    FT     WN  DF+V++F+       +T    L   S ++ 
Sbjct: 1293 LYTMECILKLIA--FRCFYFTIA---WNIFDFMVVIFSITGLCLPMTVGSYLVPPSLVQL 1347

Query: 216  FRVLRALKTISVIPGLK---TIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLK 272
              + R +  + +  G K    ++  L+ S+  L ++++L    + ++A+ G+  F   +K
Sbjct: 1348 ILLSRIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNF-AYVK 1406

Query: 273  HKCFRNSLENNETLESIM 290
             +   N + N ET  + M
Sbjct: 1407 KEAGINDVSNFETFGNSM 1424


>gi|115583667 sodium channel, voltage-gated, type XI, alpha [Homo
            sapiens]
          Length = 1791

 Score = 1301 bits (3367), Expect = 0.0
 Identities = 696/1268 (54%), Positives = 895/1268 (70%), Gaps = 67/1268 (5%)

Query: 667  DMLNDPNLRQRAMSRASILTNTVEELEESRQKCPPWWYRFAHKFLIWNCSPYWIKFKKCI 726
            D   DP  RQRA+S  SILT T++E E+S++ C P     A K+L+WNC P W+  KK +
Sbjct: 511  DEHGDPLQRQRALSAVSILTITMKEQEKSQEPCLPCGENLASKYLVWNCCPQWLCVKKVL 570

Query: 727  YFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAIGNLVFTGIFAAEMVLKLIA 786
              ++ DPF +LAITICI++NT+F+AMEHH M   F+ +L IGNLVFT IF AEM LK+IA
Sbjct: 571  RTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMCLKIIA 630

Query: 787  MDPYEYFQVGWNIFDSLIVTLSLVELFLADVEGLS--VLRSFRLLRVFKLAKSWPTLNML 844
            +DPY YF+ GWNIFDS++  LS  ++    ++  S   LRSFR+LRVFKLAKSWPTLN L
Sbjct: 631  LDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAKSWPTLNTL 690

Query: 845  IKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSY------KECVCKINDDCTLPRWH 898
            IKIIGNSVGALG+LT+VL I++FIF+VVGMQLFG+S+      K C         L  WH
Sbjct: 691  IKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTGPTVSCLRHWH 750

Query: 899  MNDFFHSFLIVFRVLCGEWIETMWDCMEVAG--QAMCLIVYMMVMVIGNLVVLNLFLALL 956
            M DF+HSFL+VFR+LCGEWIE MW+CM+ A    ++C+IV++++ VIG LVVLNLF+ALL
Sbjct: 751  MGDFWHSFLVVFRILCGEWIENMWECMQEANASSSLCVIVFILITVIGKLVVLNLFIALL 810

Query: 957  LSSFSSDNLTA-IEEDPDANNLQIAVTRIKKGINYVKQTLREFILKAFSKKPKISREIRQ 1015
            L+SFS++     +E +     +Q+A+ R ++   +V+ TL  F  K + +K  + ++   
Sbjct: 811  LNSFSNEERNGNLEGEARKTKVQLALDRFRRAFCFVRHTLEHFCHK-WCRKQNLPQQKEV 869

Query: 1016 AEDLNTKKENYISNHTLAEMSKGHNFLKEKDKISGFGSSVD-KH-------LMEDSDGQS 1067
            A     + ++ I    + EM +G    +E   ++    ++  +H       L E+ D   
Sbjct: 870  AGGCAAQSKDIIP--LVMEMKRGSETQEELGILTSVPKTLGVRHDWTWLAPLAEEEDDVE 927

Query: 1068 FI-HNPSLTVTVPIAPGES-DLENMNAEELSS----------DSDSEYSKVRLNRSSS-- 1113
            F   + +  +T P    ++ +L   N +  S             D  +  ++  R  S  
Sbjct: 928  FSGEDNAQRITQPEPEQQAYELHQENKKPTSQRVQSVEIDMFSEDEPHLTIQDPRKKSDV 987

Query: 1114 ----SECSTVDNPLPGEGEEAEAEPMNSDEPEACFTDGCVRRFSCCQVNIESGKGKIWWN 1169
                SECST+D    G G   E  P    +PE C   G    F CC V+       IWWN
Sbjct: 988  TSILSECSTIDLQ-DGFGWLPEMVPKK--QPERCLPKGFGCCFPCCSVDKRKPPWVIWWN 1044

Query: 1170 IRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILE 1229
            +RKTCY+IV+HSWFESFI+ +ILLSSGAL FED+++E +  I+ +L   D IFT+IFILE
Sbjct: 1045 LRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILE 1104

Query: 1230 MLLKWIAYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRA 1289
            M+LKW+A+G+  YFT+AWC LDF+IV VS+ TL+       +L  +KS RTLRALRPLRA
Sbjct: 1105 MVLKWVAFGFGKYFTSAWCCLDFIIVIVSVTTLI-------NLMELKSFRTLRALRPLRA 1157

Query: 1290 LSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDGSRFP 1349
            LS+FEGM+VVVNALIGAIP+I+NVLLVCLIFWL+F I+GV  F+GKF +CIN TD S   
Sbjct: 1158 LSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKFGKCINGTD-SVIN 1216

Query: 1350 ASQVPNRSECFALMNVSQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVN 1409
             + + N+S+C      S N  W N KVNFDNVG  YL+LLQVATFKGW  I+YAAVDS  
Sbjct: 1217 YTIITNKSQC-----ESGNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTE 1271

Query: 1410 VDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKK 1469
             ++QP++E +   YIYFVVFIIFGSFFTLNLFIGVIIDNFNQQ+KKLGGQDIFMTEEQKK
Sbjct: 1272 KEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKK 1331

Query: 1470 YYNAMKKLGSKKPQKPIPRPGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQS 1529
            YYNAMKKLGSKKPQKPIPRP NK QG +FD+VT+Q FDI I+ LI LNM++MM E   Q 
Sbjct: 1332 YYNAMKKLGSKKPQKPIPRPLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESYNQP 1391

Query: 1530 QHMTEVLYWINVVFIILFTGECVLKLISLRHYYFTVGWNIFDFVVVIISIVGMFLADLIE 1589
            + M  +L  +N VF+++FT EC++K+ +LR YYFT GWN+FD VVV++SIV   ++ L  
Sbjct: 1392 KAMKSILDHLNWVFVVIFTLECLIKIFALRQYYFTNGWNLFDCVVVLLSIVSTMISTLEN 1451

Query: 1590 TYFV--SPTLFRVIRLARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY 1647
               +   PTLFR++RLARIGRILRLV+ A+GIRTLLFALMMSLP+LFNIGLLLFL+MFIY
Sbjct: 1452 QEHIPFPPTLFRIVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIY 1511

Query: 1648 AIFGMSNFAYVKKEDGINDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPK 1707
            AI GM+ F+ V  E GI+D+FNF+TF +SM+CLFQI+TSAGWD LL+P+L SK   C   
Sbjct: 1512 AILGMNWFSKVNPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLRSK-ESC--- 1567

Query: 1708 KVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDD 1767
                 +S   +C  P +   YFVSYIIISFL+VVNMYIAVILENF+ ATEES +PL EDD
Sbjct: 1568 -----NSSSENCHLPGIATSYFVSYIIISFLIVVNMYIAVILENFNTATEESEDPLGEDD 1622

Query: 1768 FEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHC 1827
            F++FYEVWEKFDP+ATQFI++S LSDFA AL  PL +AKPNK Q + MDLPMVS DR+HC
Sbjct: 1623 FDIFYEVWEKFDPEATQFIKYSALSDFADALPEPLRVAKPNKYQFLVMDLPMVSEDRLHC 1682

Query: 1828 LDILFAFTKRVLGESGEMDSLRSQMEERFMSANPSKVSYEPITTTLKRKQEDVSATVIQR 1887
            +DILFAFT RVLG S  +DS+++ MEE+FM ANP K  YEPI TT KRK+E+  A +IQ+
Sbjct: 1683 MDILFAFTARVLGGSDGLDSMKAMMEEKFMEANPLKKLYEPIVTTTKRKEEERGAAIIQK 1742

Query: 1888 AYRRYRLR 1895
            A+R+Y ++
Sbjct: 1743 AFRKYMMK 1750



 Score =  416 bits (1070), Expect = e-116
 Identities = 230/481 (47%), Positives = 309/481 (64%), Gaps = 29/481 (6%)

Query: 7   PGPQSFVHFTKQSLALIEQRIAERKSKEPKEEKKDDDEEAPKPSSDLEAGKQLPFIYGDI 66
           P  ++F  FT  SLA IE+RIA +K K+ K + +  +   P+P  DL+A ++LP +YGDI
Sbjct: 11  PDERNFRPFTSDSLAAIEKRIAIQKEKK-KSKDQTGEVPQPRPQLDLKASRKLPKLYGDI 69

Query: 67  PPGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRISIKILVHS 126
           P  ++ +PLEDLDP+Y + KTF+VLN+ +TI+RF+A  AL++  PF+ +R ++I++ VHS
Sbjct: 70  PRELIGKPLEDLDPFYRNHKTFMVLNRKRTIYRFSAKHALFIFGPFNSIRSLAIRVSVHS 129

Query: 127 LFSMLIMCTILTNCIFMTM----NNPPDWTKNVEYTFTGIYTFESLVKILARGFCVGEFT 182
           LFSM I+ T++ NC+FM      N+  + T   E  FTGIY FE+L+KILARGF + EF+
Sbjct: 130 LFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAECVFTGIYIFEALIKILARGFILDEFS 189

Query: 183 FLRDPWNWLDFVVIVFAYLTEFVNLG-NVSALRTFRVLRALKTISVIPGLKTIVGALIQS 241
           FLRDPWNWLD +VI  A ++    +   +  LRTFRV RALK ISV+  LK IVGAL++S
Sbjct: 190 FLRDPWNWLDSIVIGIAIVSYIPGITIKLLPLRTFRVFRALKAISVVSRLKVIVGALLRS 249

Query: 242 VKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETLESIMNTLESEEDFRK 301
           VKKL +V+ILT FCLS+FAL+G QLFMG+L  KC     +N    E+  +  E +E+   
Sbjct: 250 VKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDCKNISNPEAYDHCFEKKEN--- 306

Query: 302 YFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQD 361
                  S +  +CG    +  C   Y C     NPDY YT+FD F W+FLA+FRLMTQD
Sbjct: 307 -------SPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWSFLAMFRLMTQD 359

Query: 362 YWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANIEEAKQKEL 421
            WE LYQQTLR  G   + FF+VVIFLGSFYLINL LAVV MAYEEQN+    E + KE 
Sbjct: 360 SWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEEQNKNVAAEIEAKEK 419

Query: 422 EFQQMLDRLKKEQEEAEAIAAAAAEYTSIRRSRIMGLSESSSETSKLSSKSAKERRNRRK 481
            FQ+    LK   EE EA+ A   + +S+          +S ETS  + K  K   N+++
Sbjct: 420 MFQEAQQLLK---EEKEALVAMGIDRSSL----------TSLETSYFTPKKRKLFGNKKR 466

Query: 482 K 482
           K
Sbjct: 467 K 467



 Score =  118 bits (296), Expect = 5e-26
 Identities = 160/806 (19%), Positives = 312/806 (38%), Gaps = 142/806 (17%)

Query: 704  YRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKN 763
            YRF+ K  ++   P+    +     + +     + I   +++N +FMA    P      N
Sbjct: 101  YRFSAKHALFIFGPF-NSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATG--PAKNSNSN 157

Query: 764  VLAIGNLVFTGIFAAEMVLKLIA----MDPYEYFQVGWNIFDSLIVTLSLVELFLADVEG 819
               I   VFTGI+  E ++K++A    +D + + +  WN  DS+++ +++V         
Sbjct: 158  NTDIAECVFTGIYIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIK 217

Query: 820  LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-- 877
            L  LR+FR+ R  K       L +++  +  SV  L N+ ++    + IFA+VG QLF  
Sbjct: 218  LLPLRTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMG 277

Query: 878  ----------------GKSYKEC--------------------VCKINDDCTLPR----- 896
                             ++Y  C                     C I  +C   +     
Sbjct: 278  SLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDY 337

Query: 897  --WHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVYMMVMVIGNLVVLNLFLA 954
               + ++F  SFL +FR++  +  E ++           +  +++V+ +G+  ++NL LA
Sbjct: 338  NYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLA 397

Query: 955  LLLSSFSSDNLTAIEEDPDANNLQIAVTRIKKGINYVKQTLREFILKAFSKKPKISREIR 1014
            ++  ++   N           N+   +   +K     +Q L+E       K+  ++  I 
Sbjct: 398  VVTMAYEEQN----------KNVAAEIEAKEKMFQEAQQLLKE------EKEALVAMGID 441

Query: 1015 QAEDLNTKKENYIS---NHTLAEMSKGHNFLKEKDKISGFGSSVDKHLMEDSDGQSFIHN 1071
            ++  L + + +Y +           +   FL+E  K    GS  D+   +          
Sbjct: 442  RS-SLTSLETSYFTPKKRKLFGNKKRKSFFLRESGKDQPPGSDSDEDCQK---------- 490

Query: 1072 PSLTVTVPIAPGESDLENMNAEELSSDSDSEYSKVRLNRSSSSECSTVDNPLPGEGEEAE 1131
                      P   +     ++ LS D   E+      + + S  S +   +        
Sbjct: 491  ---------KPQLLEQTKRLSQNLSLDHFDEHGDPLQRQRALSAVSILTITM-------- 533

Query: 1132 AEPMNSDEPEACFTDGCVRRF---SCCQVNIESGKGKIWWNIRKTCYKIVEHSWFESFIV 1188
             E   S EP     +    ++   +CC           W  ++K    ++   + E  I 
Sbjct: 534  KEQEKSQEPCLPCGENLASKYLVWNCCPQ---------WLCVKKVLRTVMTDPFTELAIT 584

Query: 1189 LMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILEMLLKWIAYGYKTYFTNAWC 1248
            + I++++  LA E  + + + + + +L   + +FT IFI EM LK IA     YF   W 
Sbjct: 585  ICIIINTVFLAME--HHKMEASFEKMLNIGNLVFTSIFIAEMCLKIIALDPYHYFRRGWN 642

Query: 1249 WLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIP 1308
              D ++  +S   ++   L       ++S R LR  +  ++      +  ++   +GA+ 
Sbjct: 643  IFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALG 702

Query: 1309 SIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDGSRFPASQVPNRSECFALMNVSQN 1368
            S + V+LV +IF  IFS++G+ LF   F       +  + P    P       L +    
Sbjct: 703  S-LTVVLVIVIF--IFSVVGMQLFGRSF-------NSQKSPKLCNPTGPTVSCLRHWHMG 752

Query: 1369 VRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVV 1428
              W +  V F  +  G            W   M+  +   N         S    I F++
Sbjct: 753  DFWHSFLVVF-RILCG-----------EWIENMWECMQEANAS-------SSLCVIVFIL 793

Query: 1429 FIIFGSFFTLNLFIGVIIDNFNQQKK 1454
              + G    LNLFI +++++F+ +++
Sbjct: 794  ITVIGKLVVLNLFIALLLNSFSNEER 819



 Score = 99.8 bits (247), Expect = 2e-20
 Identities = 78/338 (23%), Positives = 155/338 (45%), Gaps = 47/338 (13%)

Query: 1169 NIRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFIL 1228
            +IR    ++  HS F  FI+  ++++   +A             I    A+ +FT I+I 
Sbjct: 117  SIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDI----AECVFTGIYIF 172

Query: 1229 EMLLKWIAYGYK----TYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRAL 1284
            E L+K +A G+     ++  + W WLD +++ +++V+ +           +  LRT R  
Sbjct: 173  EALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITI-----KLLPLRTFRVF 227

Query: 1285 RPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF------YE 1338
            R L+A+S    ++V+V AL+ ++  ++NV+++      IF+++G  LF G         +
Sbjct: 228  RALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRD 287

Query: 1339 CINTTDGSRF-----PASQVPNRSECFALM-NVSQNVRW--KNLKV-------NFDNVGL 1383
            C N ++   +          P    C   M N + ++++  K+ K+       NFDN G 
Sbjct: 288  CKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGW 347

Query: 1384 GYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIG 1443
             +L++ ++ T   W            + +Q      LY   +F+V I  GSF+ +NL + 
Sbjct: 348  SFLAMFRLMTQDSWE----------KLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLA 397

Query: 1444 VIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKK 1481
            V+   + +Q K +  +   +  ++K +  A + L  +K
Sbjct: 398  VVTMAYEEQNKNVAAE---IEAKEKMFQEAQQLLKEEK 432



 Score = 86.7 bits (213), Expect = 2e-16
 Identities = 76/315 (24%), Positives = 137/315 (43%), Gaps = 62/315 (19%)

Query: 115  LRRISIKILVHSLFSMLIMCTILTNC---IF--MTMNNPPDWTKNVEYT---FTGIYTFE 166
            LR+   +I+ HS F   I+  IL +    IF  + + N P   + +  T   FT I+  E
Sbjct: 1045 LRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILE 1104

Query: 167  SLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTIS 226
             ++K +A GF      +    W  LDF++++ + +T  +NL  + + RT R LR L+ +S
Sbjct: 1105 MVLKWVAFGFG----KYFTSAWCCLDFIIVIVS-VTTLINLMELKSFRTLRALRPLRALS 1159

Query: 227  VIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETL 286
               G+K +V ALI ++  + +V+++ +    VF ++G+  F G                 
Sbjct: 1160 QFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSG----------------- 1202

Query: 287  ESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEG-YTCVKIGRNPDYGYTSFD 345
                          K+   + G+   +     T+  QC  G ++ +    N       FD
Sbjct: 1203 --------------KFGKCINGTDSVINYTIITNKSQCESGNFSWINQKVN-------FD 1241

Query: 346  TFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYM----------IFFVVVIFLGSFYLIN 395
                A+LAL ++ T   W ++    + +  K             I+FVV I  GSF+ +N
Sbjct: 1242 NVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFGSFFTLN 1301

Query: 396  LILAVVAMAYEEQNQ 410
            L + V+   + +Q +
Sbjct: 1302 LFIGVIIDNFNQQQK 1316



 Score = 70.5 bits (171), Expect = 2e-11
 Identities = 65/331 (19%), Positives = 139/331 (41%), Gaps = 68/331 (20%)

Query: 115 LRRISIKILVHSLFSMLIMCTILTNCIFMTMNNPP-----DWTKNV-EYTFTGIYTFESL 168
           ++++   ++      + I   I+ N +F+ M +       +   N+    FT I+  E  
Sbjct: 566 VKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMC 625

Query: 169 VKILARGFCVGEFTFLRDPWNWLDFVVIVFAY---LTEFVNLGNVSALRTFRVLRALKTI 225
           +KI+A    +  + + R  WN  D +V + ++   +   +   +   LR+FRVLR  K  
Sbjct: 626 LKIIA----LDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLA 681

Query: 226 SVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNET 285
              P L T++  +  SV  L  + ++ V  + +F+++G+QLF  +               
Sbjct: 682 KSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRS--------------- 726

Query: 286 LESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYT--CVKIGRNPDYGYTS 343
                                   K   LC         P G T  C++     D+ +  
Sbjct: 727 --------------------FNSQKSPKLCN--------PTGPTVSCLRHWHMGDFWH-- 756

Query: 344 FDTFSWAFLALFRLMTQDYWENLYQ--QTLRAAGKTYMIFFVVVIFLGSFYLINLILAVV 401
                 +FL +FR++  ++ EN+++  Q   A+    +I F+++  +G   ++NL +A++
Sbjct: 757 ------SFLVVFRILCGEWIENMWECMQEANASSSLCVIVFILITVIGKLVVLNLFIALL 810

Query: 402 AMAYEEQNQANIEEAKQKELEFQQMLDRLKK 432
             ++  + +    E + ++ + Q  LDR ++
Sbjct: 811 LNSFSNEERNGNLEGEARKTKVQLALDRFRR 841



 Score = 55.1 bits (131), Expect = 7e-07
 Identities = 46/192 (23%), Positives = 90/192 (46%), Gaps = 29/192 (15%)

Query: 100  FNATPALYMLSPFSPLRR-------ISIKILVHSLFSMLIMCTILTNCIFMTMN--NPPD 150
            +NA   L    P  P+ R       +   I+   +F ++I+  I+ N I M     N P 
Sbjct: 1333 YNAMKKLGSKKPQKPIPRPLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESYNQPK 1392

Query: 151  WTKNV----EYTFTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVN 206
              K++     + F  I+T E L+KI    F + ++ F  + WN  D VV++ + ++  ++
Sbjct: 1393 AMKSILDHLNWVFVVIFTLECLIKI----FALRQYYF-TNGWNLFDCVVVLLSIVSTMIS 1447

Query: 207  -LGN----------VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFC 255
             L N             +R  R+ R L+ +    G++T++ AL+ S+  L ++ +L    
Sbjct: 1448 TLENQEHIPFPPTLFRIVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLI 1507

Query: 256  LSVFALIGLQLF 267
            + ++A++G+  F
Sbjct: 1508 MFIYAILGMNWF 1519



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 70/369 (18%), Positives = 139/369 (37%), Gaps = 99/369 (26%)

Query: 1489 PGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMV-EKEGQSQHMTEVLYWINVVFIILF 1547
            P N I+     +  +  F + I+  + +N V M     +  + + T++      VF  ++
Sbjct: 114  PFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDIA---ECVFTGIY 170

Query: 1548 TGECVLKLIS----LRHYYFTVG-WNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIR 1602
              E ++K+++    L  + F    WN  D +V+ I+IV       I+           +R
Sbjct: 171  IFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIKLL--------PLR 222

Query: 1603 LARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNF------- 1655
              R+ R L+ +     ++ ++ AL+ S+  L N+ +L F  + I+A+ G   F       
Sbjct: 223  TFRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLK 282

Query: 1656 -----------------AYVKKEDG-------------------------INDMFN---F 1670
                              + KKE+                          IN  +N   F
Sbjct: 283  CISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNF 342

Query: 1671 ETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFV 1730
            + FG S + +F++ T   W+ L    L +                          +F+F+
Sbjct: 343  DNFGWSFLAMFRLMTQDSWEKLYQQTLRT---------------------TGLYSVFFFI 381

Query: 1731 SYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWEKFDPDATQFIEFSK 1790
              I +    ++N+ +AV+    ++A EE  + ++ +      E  EK   +A Q ++  K
Sbjct: 382  VVIFLGSFYLINLTLAVV----TMAYEEQNKNVAAE-----IEAKEKMFQEAQQLLKEEK 432

Query: 1791 LSDFAAALD 1799
             +  A  +D
Sbjct: 433  EALVAMGID 441



 Score = 31.6 bits (70), Expect = 8.0
 Identities = 20/84 (23%), Positives = 40/84 (47%), Gaps = 21/84 (25%)

Query: 336  NPDYGYT---SFDTFSWAFLALFRLMTQDYWENLYQQTLRA---------------AGKT 377
            NP+ G     +F TF+ + L LF++ T   W++L    LR+                  +
Sbjct: 1523 NPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLRSKESCNSSSENCHLPGIATS 1582

Query: 378  YMIFFVVVIFLGSFYLINLILAVV 401
            Y + ++++ FL    ++N+ +AV+
Sbjct: 1583 YFVSYIIISFL---IVVNMYIAVI 1603


>gi|239748090 PREDICTED: similar to sodium channel, voltage-gated,
            type V, alpha (long QT syndrome 3) [Homo sapiens]
          Length = 1637

 Score =  988 bits (2554), Expect = 0.0
 Identities = 531/849 (62%), Positives = 629/849 (74%), Gaps = 65/849 (7%)

Query: 948  VLNLFLALLLSSFSSDNLTAIEEDPDANNLQIAVTRIKKGINYVKQTLREFILKAFSKKP 1007
            VLNLFLALLLSSFS+DNLTA +ED + NNLQ+A+ RI++G+ +VK+T  +F      ++P
Sbjct: 631  VLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRP 690

Query: 1008 KISREIRQAEDLNTKKENYISNHTLAEMSKGHNFLKEKDKISGFGSSVDKHLMEDSDGQS 1067
            +    +     L +      S     E  K     KE     G           +  GQ 
Sbjct: 691  QKPAALAAQGQLPSCIATPYSPPP-PETEKVPPTRKETRFEEG-----------EQPGQG 738

Query: 1068 FIHNPSLTVTVPIAPGESDLENMNAEELSSDSDSEYSKVRLNRSSSSECSTVDNPLPGEG 1127
               +P   V VPIA  ESD ++   +E +S    E S                       
Sbjct: 739  TPGDPE-PVCVPIAVAESDTDDQEEDEENSLGTEEESS---------------------- 775

Query: 1128 EEAEAEPMNSDEPEACFTDGCVRRFSCCQVNIESGKGKIWWNIRKTCYKIVEHS-----W 1182
            ++ E++P+ S  PEA                      + W  +  T     E S     W
Sbjct: 776  KQQESQPV-SGGPEA------------------PPDSRTWSQVSATASSEAEASASQADW 816

Query: 1183 FESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILEMLLKWIAYGYKTY 1242
             + +         G  AFEDIY+E +KTIK++LEYADK+FTY+F+LEMLLKW+AYG+K Y
Sbjct: 817  RQQWKAEPQAPGCGE-AFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKY 875

Query: 1243 FTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNA 1302
            FTNAWCWLDFLIVDVSLV+LVANTLG++++GPIKSLRTLRALRPLRALSRFEGMRVVVNA
Sbjct: 876  FTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNA 935

Query: 1303 LIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDGSRFPASQ--VPNRSECF 1360
            L+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF  CIN T+G   P +   V N+S+C 
Sbjct: 936  LVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGD-LPLNYTIVNNKSQCE 994

Query: 1361 ALMNVSQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSL 1420
            +L N++  + W  +KVNFDNVG GYL+LLQVATFKGW  IMYAAVDS   ++QP++EY+L
Sbjct: 995  SL-NLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNL 1053

Query: 1421 YMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSK 1480
            YMYIYFV+FIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSK
Sbjct: 1054 YMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSK 1113

Query: 1481 KPQKPIPRPGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWIN 1540
            KPQKPIPRP NK QG IFD+VT QAFD++IM LICLNMVTMMVE + QS     +L  IN
Sbjct: 1114 KPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKIN 1173

Query: 1541 VVFIILFTGECVLKLISLRHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRV 1600
            ++F+ +FTGEC++KL +LRHYYFT  WNIFDFVVVI+SIVG  L+D+I+ YF SPTLFRV
Sbjct: 1174 LLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRV 1233

Query: 1601 IRLARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKK 1660
            IRLARIGRILRL++GAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY+IFGM+NFAYVK 
Sbjct: 1234 IRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKW 1293

Query: 1661 EDGINDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCG 1720
            E GI+DMFNF+TF NSM+CLFQITTSAGWDGLL+PILN+ PP CDP   +   S  GDCG
Sbjct: 1294 EAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGS-RGDCG 1352

Query: 1721 NPSVGIFYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWEKFDP 1780
            +P+VGI +F +YIIISFL+VVNMYIA+ILENFSVATEESTEPLSEDDF+MFYE+WEKFDP
Sbjct: 1353 SPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDP 1412

Query: 1781 DATQFIEFS 1789
            +ATQFIE+S
Sbjct: 1413 EATQFIEYS 1421



 Score =  679 bits (1751), Expect = 0.0
 Identities = 366/638 (57%), Positives = 457/638 (71%), Gaps = 48/638 (7%)

Query: 4   LPPPGPQSFVHFTKQSLALIEQRIAERKSKEPK--EEKKDD--DEEAPKPSSDLEAGKQL 59
           L P G  SF  FT++SLA IE+R+AE++++     +E ++   +EEAP+P  DL+A K+L
Sbjct: 5   LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64

Query: 60  PFIYGDIPPGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRIS 119
           P +YG+ P  ++ EPLEDLDP+Y+ +KTFIVLNKGKTIFRF+AT ALY+LSPF P+RR +
Sbjct: 65  PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124

Query: 120 IKILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKILARGFCVG 179
           +KILVHSLF+MLIMCTILTNC+FM  ++PP WTK VEYTFT IYTFESLVKILARGFC+ 
Sbjct: 125 VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184

Query: 180 EFTFLRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 239
            FTFLRDPWNWLDF VI+ AY TEFV+LGNVSALRTFRVLRALKTISVI GLKTIVGALI
Sbjct: 185 AFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALI 244

Query: 240 QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETLES------IMNTL 293
           QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNL+HKC RN    N T  S      +  +L
Sbjct: 245 QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLVWESL 304

Query: 294 ESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLA 353
           +      + +    G+ D LLCG S+D+G CPEGY C+K G NPD+GYTSFD+F+WAFLA
Sbjct: 305 DLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLA 364

Query: 354 LFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANI 413
           LFRLMTQD WE LYQQTLR+AGK YMIFF++VIFLGSFYL+NLILAVVAMAYEEQNQA I
Sbjct: 365 LFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATI 424

Query: 414 EEAKQKELEFQQMLDRLKKEQEEAEAIAAAAAEYTSIRRSRIMGLSESSSETSKLSSKSA 473
            E ++KE  FQ+ ++ LKKE E             ++    +  +S SS E S L+  ++
Sbjct: 425 AETEEKEKRFQEAMEMLKKEHE-------------ALTIRGVDTVSRSSLEMSPLAPVNS 471

Query: 474 KERRNRRKKKNQKKLSSGEEKGDAEKLSKSESEDSIRRKSFHLGVEGHRRAHEKRLSTPN 533
            ERR++R+    K++SSG E+   ++L KS+SED  R  + HL +        + LS  +
Sbjct: 472 HERRSKRR----KRMSSGTEECGEDRLPKSDSEDGPRAMN-HLSL-------TRGLSRTS 519

Query: 534 QSPLSIRGSLFSARRSSRTSLFSFKGRGRDIGSETEFADDEHSIFGDNESRRGSLFVPHR 593
             P S RGS+F+ RR             RD+GSE +FADDE+S  G++ES   SL VP  
Sbjct: 520 MKPRSSRGSIFTFRR-------------RDLGSEADFADDENSTAGESESHHTSLLVPWP 566

Query: 594 PQERRSSNISQASRSPPMLPVNGKMHSAVDCNGVVSLV 631
            +   +        S P   ++GK +S VDCNGVVSL+
Sbjct: 567 LRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGVVSLL 604



 Score = 99.4 bits (246), Expect = 3e-20
 Identities = 87/349 (24%), Positives = 158/349 (45%), Gaps = 68/349 (19%)

Query: 1170 IRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILE 1229
            IR+   KI+ HS F   I+  IL +   +A  D     K        Y +  FT I+  E
Sbjct: 120  IRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTK--------YVEYTFTAIYTFE 171

Query: 1230 MLLKWIAYGYK----TYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALR 1285
             L+K +A G+     T+  + W WLDF ++      ++A T  + DLG + +LRT R LR
Sbjct: 172  SLVKILARGFCLHAFTFLRDPWNWLDFSVI------IMAYTTEFVDLGNVSALRTFRVLR 225

Query: 1286 PLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-------YE 1338
             L+ +S   G++ +V ALI ++  + +V+++ +    +F+++G+ LF G         + 
Sbjct: 226  ALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFT 285

Query: 1339 CINTTDGSRFPASQV-------PNRSECFALMNVSQNV--------------RWKNLK-- 1375
             +N T+GS      V        +  E + L N + +V               ++ LK  
Sbjct: 286  ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAG 345

Query: 1376 -------VNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVV 1428
                    +FD+    +L+L ++ T   W  +    + S            +YM I+F++
Sbjct: 346  ENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG---------KIYM-IFFML 395

Query: 1429 FIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKL 1477
             I  GSF+ +NL + V+   + +Q +    +     E++K++  AM+ L
Sbjct: 396  VIFLGSFYLVNLILAVVAMAYEEQNQATIAE---TEEKEKRFQEAMEML 441



 Score = 94.7 bits (234), Expect = 8e-19
 Identities = 72/269 (26%), Positives = 131/269 (48%), Gaps = 36/269 (13%)

Query: 721  KFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAIGNLVFTGIFAAEM 780
            K++  I+ IV     D+ I   I LN + M +E    + E  N+LA  NL+F  IF  E 
Sbjct: 1125 KYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGEC 1184

Query: 781  VLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADV--------EGLSVLRSFRLLRVF 832
            ++KL A+  Y YF   WNIFD ++V LS+V   L+D+            V+R  R+ R+ 
Sbjct: 1185 IVKLAALRHY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRIL 1243

Query: 833  KLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDC 892
            +L +    +  L+  +  S+ AL N+ L+L +++FI+++ GM  F  +Y +    I+D  
Sbjct: 1244 RLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANF--AYVKWEAGIDD-- 1299

Query: 893  TLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMC------------------- 933
                ++   F +S L +F++      + +   +   G   C                   
Sbjct: 1300 ---MFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAV 1356

Query: 934  -LIVYMMVMVIGNLVVLNLFLALLLSSFS 961
             ++ +   ++I  L+V+N+++A++L +FS
Sbjct: 1357 GILFFTTYIIISFLIVVNMYIAIILENFS 1385



 Score = 82.4 bits (202), Expect = 4e-15
 Identities = 65/268 (24%), Positives = 123/268 (45%), Gaps = 51/268 (19%)

Query: 159  FTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVI------VFAYLTEFVNLGNVSA 212
            FT ++  E L+K +A GF      +  + W WLDF+++      + A    F  +G + +
Sbjct: 855  FTYVFVLEMLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKS 910

Query: 213  LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLK 272
            LRT R LR L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G   
Sbjct: 911  LRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF- 969

Query: 273  HKCFRNSLENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVK 332
             +C  N  E +  L   +   +S+                  C     +G+    +T VK
Sbjct: 970  GRCI-NQTEGDLPLNYTIVNNKSQ------------------CESLNLTGEL--YWTKVK 1008

Query: 333  IGRNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAG---------KTYM-IFF 382
            +         +FD     +LAL ++ T   W ++    + + G           YM I+F
Sbjct: 1009 V---------NFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYF 1059

Query: 383  VVVIFLGSFYLINLILAVVAMAYEEQNQ 410
            V+ I  GSF+ +NL + V+   + +Q +
Sbjct: 1060 VIFIIFGSFFTLNLFIGVIIDNFNQQKK 1087



 Score = 68.2 bits (165), Expect = 8e-11
 Identities = 52/239 (21%), Positives = 109/239 (45%), Gaps = 39/239 (16%)

Query: 762  KNVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELF-----LAD 816
            K +L   + +FT +F  EM+LK +A    +YF   W   D LIV +SLV L       A+
Sbjct: 845  KVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAE 904

Query: 817  VEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQL 876
            +  +  LR+ R LR  +    +  + +++  +  ++ ++ N+ LV  I   IF+++G+ L
Sbjct: 905  MGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNL 964

Query: 877  FGKSYKECVCKINDDC------------------------TLPRWHMNDFFHSFLIVFRV 912
            F   +  C+ +   D                         T  + + ++    +L + +V
Sbjct: 965  FAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQV 1024

Query: 913  LCGE-WIETMWDCMEVAGQA--------MCLIVYMMVMVI-GNLVVLNLFLALLLSSFS 961
               + W++ M+  ++  G          + + +Y ++ +I G+   LNLF+ +++ +F+
Sbjct: 1025 ATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFN 1083



 Score = 60.8 bits (146), Expect = 1e-08
 Identities = 44/187 (23%), Positives = 90/187 (48%), Gaps = 13/187 (6%)

Query: 704 YRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKN 763
           +RF+    ++  SP+    ++    I++    ++ I   I+ N +FMA    P   ++  
Sbjct: 103 FRFSATNALYVLSPFH-PIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE 161

Query: 764 VLAIGNLVFTGIFAAEMVLKLIA----MDPYEYFQVGWNIFDSLIVTLSLVELFLADVEG 819
                   FT I+  E ++K++A    +  + + +  WN  D  ++ ++    F+ D+  
Sbjct: 162 Y------TFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFV-DLGN 214

Query: 820 LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-G 878
           +S LR+FR+LR  K       L  ++  +  SV  L ++ ++    + +FA++G+QLF G
Sbjct: 215 VSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274

Query: 879 KSYKECV 885
               +CV
Sbjct: 275 NLRHKCV 281



 Score = 46.2 bits (108), Expect = 3e-04
 Identities = 44/190 (23%), Positives = 80/190 (42%), Gaps = 27/190 (14%)

Query: 100  FNATPALYMLSPFSPLRRISIK-------ILVHSLFSMLIMCTILTNCIFM---TMNNPP 149
            +NA   L    P  P+ R   K       I+    F + IM  I  N + M   T +  P
Sbjct: 1104 YNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSP 1163

Query: 150  DWTK---NVEYTFTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYL----- 201
            +       +   F  I+T E +VK+ A         +  + WN  DFVV++ + +     
Sbjct: 1164 EKINILAKINLLFVAIFTGECIVKLAAL-----RHYYFTNSWNIFDFVVVILSIVGTVLS 1218

Query: 202  ----TEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLS 257
                  F +      +R  R+ R L+ I    G++T++ AL+ S+  L ++ +L    + 
Sbjct: 1219 DIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMF 1278

Query: 258  VFALIGLQLF 267
            ++++ G+  F
Sbjct: 1279 IYSIFGMANF 1288



 Score = 37.0 bits (84), Expect = 0.19
 Identities = 21/88 (23%), Positives = 46/88 (52%), Gaps = 1/88 (1%)

Query: 900 NDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVYMMVMVIGNLVVLNLFLALLLSS 959
           + F  +FL +FR++  +  E ++     +   + +I +M+V+ +G+  ++NL LA++  +
Sbjct: 356 DSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMA 415

Query: 960 FSSDN-LTAIEEDPDANNLQIAVTRIKK 986
           +   N  T  E +      Q A+  +KK
Sbjct: 416 YEEQNQATIAETEEKEKRFQEAMEMLKK 443


>gi|110349767 calcium channel, voltage-dependent, L type, alpha 1S
            subunit [Homo sapiens]
          Length = 1873

 Score =  427 bits (1098), Expect = e-119
 Identities = 351/1187 (29%), Positives = 566/1187 (47%), Gaps = 172/1187 (14%)

Query: 705  RFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNV 764
            +F   +  WN    W    KC   +    F  L I I + LNTL +A EHH        +
Sbjct: 409  QFIRHWRQWNRIFRW----KCHDIVKSKVFYWLVILI-VALNTLSIASEHHNQPLWLTRL 463

Query: 765  LAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADVE-----G 819
              I N V   +F  EM++K+  +   +YF   +N FD  +V   ++E+ L +       G
Sbjct: 464  QDIANRVLLSLFTTEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMTPLG 523

Query: 820  LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGK 879
            +SVLR  RLLR+FK+ K W +L+ L+  + NS+ ++ +L L+L + + IFA++GMQLFG 
Sbjct: 524  ISVLRCIRLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGG 583

Query: 880  SYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAG----QAMCL 934
             Y        +D  + R + ++F  + + VF+VL GE W   M++ +   G      M +
Sbjct: 584  RYDF------EDTEVRRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYGGPSYPGMLV 637

Query: 935  IVYMMVM-VIGNLVVLNLFLALLLSSFSSDNLTAIEEDPDANNLQIAVTRIKKGINYVKQ 993
             +Y +++ V GN ++LN+FLA+ +     DNL   E          ++T  +K       
Sbjct: 638  CIYFIILFVCGNYILLNVFLAIAV-----DNLAEAE----------SLTSAQKA------ 676

Query: 994  TLREFILKAFSKKPKISREIRQAEDLNTKKENYISNHTLAEMSKGHNFLKEKDKISGFGS 1053
                   KA  KK +                         +MSKG     E++K     S
Sbjct: 677  -------KAEEKKRR-------------------------KMSKGLPDKSEEEK-----S 699

Query: 1054 SVDKHLMEDSDGQSFIHNPSLTVTVPIAPGESDLENMNAEELSSDSDSEYSKVRLNRSSS 1113
            ++ K L +   G+        T  + I   ES++  +     S+D               
Sbjct: 700  TMAKKLEQKPKGEGI----PTTAKLKIDEFESNVNEVKDPYPSAD--------------- 740

Query: 1114 SECSTVDNPLPGEGEEAEAEPMNSDEP----EACFTDGCVRRFSCCQVNIESGKGKIWWN 1169
                      PG+ EE E E   S  P    E    +  V         I S   KI   
Sbjct: 741  ---------FPGDDEEDEPEIPLSPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKI--- 788

Query: 1170 IRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILE 1229
             R  C++IV  +WF +FI+L ILLSS ALA ED  I        IL++ D  FT +F +E
Sbjct: 789  -RVLCHRIVNATWFTNFILLFILLSSAALAAEDP-IRADSMRNQILKHFDIGFTSVFTVE 846

Query: 1230 MLLKWIAYGY----KTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALR 1285
            ++LK   YG      ++  N +  LD L+V VSL+++    L  S +  +K LR LR LR
Sbjct: 847  IVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISM---GLESSAISVVKILRVLRVLR 903

Query: 1286 PLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDG 1345
            PLRA++R +G++ VV  +  AI +I N++LV  +   +F+ +GV LF GKF+ C   TD 
Sbjct: 904  PLRAINRAKGLKHVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKGKFFRC---TDL 960

Query: 1346 SRFPASQVPNRSECFALMNVSQ----NVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIM 1401
            S+    +       +   +  Q    +  W +   +FDNV    +SL  V+TF+GW  ++
Sbjct: 961  SKMTEEECRGYYYVYKDGDPMQIELRHREWVHSDFHFDNVLSAMMSLFTVSTFEGWPQLL 1020

Query: 1402 YAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1461
            Y A+DS   D  P Y   + M I+F+++II  +FF +N+F+G +I  F +Q     G+  
Sbjct: 1021 YKAIDSNAEDVGPIYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQ-----GETE 1075

Query: 1462 FMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKIQGCIFDLVTNQAFDISIMVLICLNMVTM 1521
            +   E  K      +   K        P N  Q  ++ +VT+  F+  +  LI LN + +
Sbjct: 1076 YKNCELDKNQRQCVQYALKARPLRCYIPKNPYQYQVWYIVTSSYFEYLMFALIMLNTICL 1135

Query: 1522 MVEKEGQSQHMTEVLYWINVVFIILFTGECVLKLISLR-HYYFTVGWNIFDFVVVIISIV 1580
             ++   QS+ M  +   +NV F I+FT E +LKL++ +   YF   WN+FDF++VI SI+
Sbjct: 1136 GMQHYNQSEQMNHISDILNVAFTIIFTLEMILKLMAFKARGYFGDPWNVFDFLIVIGSII 1195

Query: 1581 GMFLADLIETYFVSP--------------------TLFRVIRLARIGRILRLVKGAKGIR 1620
             + L++ I+T+  S                           RL R+ R+++L+  A+G+R
Sbjct: 1196 DVILSE-IDTFLASSGGLYCLGGGCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVR 1254

Query: 1621 TLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEDG--INDMFNFETFGNSMI 1678
            TLL+  + S  AL  + LL+ ++ FIYA+ GM  F  +   DG  IN   NF+TF  +++
Sbjct: 1255 TLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALVDGTQINRNNNFQTFPQAVL 1314

Query: 1679 CLFQITTSAGWDGLLAPILNSKPPDCDPKKVH-PGSSVEGDCGNPSVGIFYFVSYIIISF 1737
             LF+  T   W  +L      K   CDP+  + PG   E  CG  +   +YF+S+ ++  
Sbjct: 1315 LLFRCATGEAWQEILLACSYGKL--CDPESDYAPGE--EYTCGT-NFAYYYFISFYMLCA 1369

Query: 1738 LVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAA 1797
             +V+N+++AVI++NF   T +    L     + F  +W ++DP+A   I+   +      
Sbjct: 1370 FLVINLFVAVIMDNFDYLTRD-WSILGPHHLDEFKAIWAEYDPEAKGRIKHLDVVTLLRR 1428

Query: 1798 LDPPLLIAK--PNKV---QLIAMDLPMVSGDRIHCLDILFAFTKRVL 1839
            + PPL   K  P++V   +L+ M++P+ S   +     LFA  +  L
Sbjct: 1429 IQPPLGFGKFCPHRVACKRLVGMNMPLNSDGTVTFNATLFALVRTAL 1475



 Score =  191 bits (485), Expect = 6e-48
 Identities = 169/672 (25%), Positives = 303/672 (45%), Gaps = 130/672 (19%)

Query: 1170 IRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYI----ERKKTIKIILEYADKIFTYI 1225
            +RK C  IVE   FE+ I+L I  +  ALA   +Y+    +   ++ + LE  +  F  +
Sbjct: 40   LRKACISIVEWKPFETIILLTIFANCVALA---VYLPMPEDDNNSLNLGLEKLEYFFLIV 96

Query: 1226 FILEMLLKWIAYGY----KTYFTNAWCWLDFLIVDVSLVTLV--------ANTLGYSDLG 1273
            F +E  +K IAYG+      Y  + W  LDF IV + + T++        ++T   S  G
Sbjct: 97   FSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKG 156

Query: 1274 P---IKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVN 1330
                +K+LR  R LRPLR +S    ++VV+N++  A+  + ++ L+ L   +I++I+G+ 
Sbjct: 157  AGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLE 216

Query: 1331 LFAGKFYE--------------------CINTTDGSRFPASQVPNRSECFALMNVSQNVR 1370
            LF GK ++                    C  T  G R       N SEC           
Sbjct: 217  LFKGKMHKTCYFIGTDIVATVENEEPSPCARTGSGRRCTI----NGSEC--------RGG 264

Query: 1371 WKNLK---VNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFV 1427
            W        +FDN G   L++ Q  T +GWT ++Y   D++  +         + +IYFV
Sbjct: 265  WPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWVNDAIGNE---------WPWIYFV 315

Query: 1428 VFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYN--------------A 1473
              I+ GSFF LNL +GV+   F ++++K   +  F    +K+  +               
Sbjct: 316  TLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLDEDLRGYMSWITQGEV 375

Query: 1474 MKKLGSKKPQKPIPRPG------------NKIQGCI--------------FDLVTNQAFD 1507
            M     ++ +  +   G            NKI   I               D+V ++ F 
Sbjct: 376  MDVEDFREGKLSLDEGGSDTESLYEIAGLNKIIQFIRHWRQWNRIFRWKCHDIVKSKVFY 435

Query: 1508 ISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTGECVLKL--ISLRHYYFTV 1565
              +++++ LN +++  E   Q   +T +    N V + LFT E ++K+  + LR Y+ ++
Sbjct: 436  WLVILIVALNTLSIASEHHNQPLWLTRLQDIANRVLLSLFTTEMLMKMYGLGLRQYFMSI 495

Query: 1566 GWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRLARIGRILRLVKGAKGIRTLLFA 1625
             +N FD  VV   I+ +    L+E+  ++P    V+R  R+ RI ++ K    +  L+ +
Sbjct: 496  -FNRFDCFVVCSGILEIL---LVESGAMTPLGISVLRCIRLLRIFKITKYWTSLSNLVAS 551

Query: 1626 LMMSLPALFNIGLLLFLVMFIYAIFGMSNF-AYVKKEDGINDMFNFETFGNSMICLFQIT 1684
            L+ S+ ++ ++ LLLFL + I+A+ GM  F      ED      NF+ F  ++I +FQ+ 
Sbjct: 552  LLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRYDFEDTEVRRSNFDNFPQALISVFQVL 611

Query: 1685 TSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGI-FYFVSYIIISFLVVVNM 1743
            T   W  ++                + G    G    P + +  YF+   +    +++N+
Sbjct: 612  TGEDWTSMM----------------YNGIMAYGGPSYPGMLVCIYFIILFVCGNYILLNV 655

Query: 1744 YIAVILENFSVA 1755
            ++A+ ++N + A
Sbjct: 656  FLAIAVDNLAEA 667



 Score =  146 bits (368), Expect = 2e-34
 Identities = 102/356 (28%), Positives = 181/356 (50%), Gaps = 50/356 (14%)

Query: 105 ALYMLSPFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTMNNP-PDWTKN--------V 155
           AL+ L+  +PLR+  I I+    F  +I+ TI  NC+ + +  P P+   N        +
Sbjct: 30  ALFCLTLENPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPEDDNNSLNLGLEKL 89

Query: 156 EYTFTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVI---VFAYLTEFVNLG---- 208
           EY F  +++ E+ +KI+A GF   +  +LR  WN LDF ++   VF  + E VN+     
Sbjct: 90  EYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSHT 149

Query: 209 ----------NVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSV 258
                     +V ALR FRVLR L+ +S +P L+ ++ ++ +++  L  + +L +F + +
Sbjct: 150 APMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVII 209

Query: 259 FALIGLQLFMGNLKHKCFRNSLENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFS 318
           +A+IGL+LF G +   C+    +       I+ T+E+EE                 C  +
Sbjct: 210 YAIIGLELFKGKMHKTCYFIGTD-------IVATVENEEPSP--------------CART 248

Query: 319 TDSGQCP-EGYTCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKT 377
               +C   G  C      P++G T FD F ++ L +++ +T + W ++      A G  
Sbjct: 249 GSGRRCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWVNDAIGNE 308

Query: 378 Y-MIFFVVVIFLGSFYLINLILAVVAMAY-EEQNQANIEEAKQKELEFQQMLDRLK 431
           +  I+FV +I LGSF+++NL+L V++  + +E+ +A      QK  E QQ+ + L+
Sbjct: 309 WPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLDEDLR 364



 Score =  102 bits (254), Expect = 4e-21
 Identities = 80/314 (25%), Positives = 148/314 (47%), Gaps = 53/314 (16%)

Query: 691  ELEESRQKCPPWWYRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFM 750
            EL++++++C     ++A K     C      ++  +++IV   + +  +   I+LNT+ +
Sbjct: 1080 ELDKNQRQC----VQYALKARPLRCYIPKNPYQYQVWYIVTSSYFEYLMFALIMLNTICL 1135

Query: 751  AMEHHPMTEEFKNVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLV 810
             M+H+  +E+  ++  I N+ FT IF  EM+LKL+A     YF   WN+FD LIV  S++
Sbjct: 1136 GMQHYNQSEQMNHISDILNVAFTIIFTLEMILKLMAFKARGYFGDPWNVFDFLIVIGSII 1195

Query: 811  ELFLADVE-------GLSVL--------------------RSFRLLRVFKLAKSWPTLNM 843
            ++ L++++       GL  L                    R FR++R+ KL      +  
Sbjct: 1196 DVILSEIDTFLASSGGLYCLGGGCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRT 1255

Query: 844  LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFF 903
            L+     S  AL  + L++ ++ FI+AV+GMQ+FGK       +IN +      +   F 
Sbjct: 1256 LLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALVDGTQINRNN-----NFQTFP 1310

Query: 904  HSFLIVFRVLCGE-WIETMWDCM----------------EVAGQAMCLIVYMMVMVIGNL 946
             + L++FR   GE W E +  C                    G       ++   ++   
Sbjct: 1311 QAVLLLFRCATGEAWQEILLACSYGKLCDPESDYAPGEEYTCGTNFAYYYFISFYMLCAF 1370

Query: 947  VVLNLFLALLLSSF 960
            +V+NLF+A+++ +F
Sbjct: 1371 LVINLFVAVIMDNF 1384



 Score = 89.4 bits (220), Expect = 3e-17
 Identities = 82/344 (23%), Positives = 159/344 (46%), Gaps = 59/344 (17%)

Query: 105  ALYMLSPFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTMNNP-------PDWTKNVEY 157
            + ++ SP + +R +  +I+  + F+  I+  IL +   +   +P           K+ + 
Sbjct: 778  SFFIFSPTNKIRVLCHRIVNATWFTNFILLFILLSSAALAAEDPIRADSMRNQILKHFDI 837

Query: 158  TFTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLT---EFVNLGNVSALR 214
             FT ++T E ++K+   G  + + +F R+ +N LD +V+  + ++   E   +  V  LR
Sbjct: 838  GFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISMGLESSAISVVKILR 897

Query: 215  TFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHK 274
              RVLR L+ I+   GLK +V  +  ++  + +++++T     +FA IG+QLF G    K
Sbjct: 898  VLRVLRPLRAINRAKGLKHVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKG----K 953

Query: 275  CFRNSLENNETLESIMNTLESEEDFRKYFY-YLEGSKDALLCGFSTDSGQCPEGYTCVKI 333
             FR +  +  T          EE+ R Y+Y Y +G    +                    
Sbjct: 954  FFRCTDLSKMT----------EEECRGYYYVYKDGDPMQIEL------------------ 985

Query: 334  GRNPDYGYTS--FDTFSWAFLALFRLMTQDYWENLYQQTLRA----AGKTY------MIF 381
             R+ ++ ++   FD    A ++LF + T + W  L  + + +     G  Y       IF
Sbjct: 986  -RHREWVHSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIF 1044

Query: 382  FVVVIFLGSFYLINLILAVVAMAYEEQNQANIEEAKQKELEFQQ 425
            F++ I L +F+++N+ +  V + ++EQ +    E K  EL+  Q
Sbjct: 1045 FIIYIILIAFFMMNIFVGFVIVTFQEQGET---EYKNCELDKNQ 1085



 Score = 86.3 bits (212), Expect = 3e-16
 Identities = 76/301 (25%), Positives = 133/301 (44%), Gaps = 62/301 (20%)

Query: 723 KKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAIG----NLVFTGIFAA 778
           K CI  +   PF +  I + I  N + +A+ + PM E+  N L +G       F  +F+ 
Sbjct: 42  KACISIVEWKPF-ETIILLTIFANCVALAV-YLPMPEDDNNSLNLGLEKLEYFFLIVFSI 99

Query: 779 EMVLKLIA----MDPYEYFQVGWNIFDSLIVTLSLVELFLADVE--------------GL 820
           E  +K+IA         Y + GWN+ D  IV L +  + L  V               GL
Sbjct: 100 EAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGL 159

Query: 821 SV--LRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF- 877
            V  LR+FR+LR  +L    P+L +++  I  ++  L ++ L++  +V I+A++G++LF 
Sbjct: 160 DVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFK 219

Query: 878 GKSYKECV--------------------------CKINDDCTLPRW--------HMNDFF 903
           GK +K C                           C IN       W        H ++F 
Sbjct: 220 GKMHKTCYFIGTDIVATVENEEPSPCARTGSGRRCTINGSECRGGWPGPNHGITHFDNFG 279

Query: 904 HSFLIVFRVLCGE-WIETMWDCMEVAGQAMCLIVYMMVMVIGNLVVLNLFLALLLSSFSS 962
            S L V++ +  E W + ++   +  G     I ++ ++++G+  +LNL L +L   F+ 
Sbjct: 280 FSMLTVYQCITMEGWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTK 339

Query: 963 D 963
           +
Sbjct: 340 E 340



 Score = 75.1 bits (183), Expect = 6e-13
 Identities = 86/383 (22%), Positives = 158/383 (41%), Gaps = 95/383 (24%)

Query: 1477 LGSKKPQKPIP----RPG---------NKIQGCIFDLVTNQAFDISIMVLICLNMVTMMV 1523
            L  K+P+KP+P    RP          N ++     +V  + F+  I++ I  N V + V
Sbjct: 11   LRKKQPKKPVPEILPRPPRALFCLTLENPLRKACISIVEWKPFETIILLTIFANCVALAV 70

Query: 1524 E---KEGQSQHMTEVLYWINVVFIILFTGECVLKLISL-----RHYYFTVGWNIFDFVVV 1575
                 E  +  +   L  +   F+I+F+ E  +K+I+      +  Y   GWN+ DF +V
Sbjct: 71   YLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIV 130

Query: 1576 IISIVGMFL--ADLIETYFVSPTL------FRVIRLARIGRILRLVKGAKGIRTLLFALM 1627
             + +  + L   ++I+++    +        + +R  R+ R LRLV G   ++ +L ++ 
Sbjct: 131  FLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIF 190

Query: 1628 MSLPALFNIGLLLFLVMFIYAIFGMSNF----------------AYVKKED--------- 1662
             ++  LF+I LL+  ++ IYAI G+  F                A V+ E+         
Sbjct: 191  KAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENEEPSPCARTGS 250

Query: 1663 ----------------GIN-DMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCD 1705
                            G N  + +F+ FG SM+ ++Q  T  GW  +L            
Sbjct: 251  GRRCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVL------------ 298

Query: 1706 PKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSE 1765
                     V    GN    I YFV+ I++    ++N+ + V+   F   T+E  +  S 
Sbjct: 299  -------YWVNDAIGNEWPWI-YFVTLILLGSFFILNLVLGVLSGEF---TKEREKAKSR 347

Query: 1766 DDFEMFYEVWEKFDPDATQFIEF 1788
              F+   E  ++ D D   ++ +
Sbjct: 348  GTFQKLREK-QQLDEDLRGYMSW 369



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 75/334 (22%), Positives = 126/334 (37%), Gaps = 121/334 (36%)

Query: 122  ILVHSLFSMLIMCTILTN--CIFMTMNNPPDWTKNVE----YTFTGIYTFESLVKILA-- 173
            I+  S F  L+   I+ N  C+ M   N  +   ++       FT I+T E ++K++A  
Sbjct: 1114 IVTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTLEMILKLMAFK 1173

Query: 174  -RGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVN------------------LGNVSA-- 212
             RG+         DPWN  DF++++ + +   ++                   GNV    
Sbjct: 1174 ARGY-------FGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDE 1226

Query: 213  --------LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGL 264
                     R FRV+R +K +S   G++T++   I+S + L  V +L V    ++A+IG+
Sbjct: 1227 SARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGM 1286

Query: 265  QLFMGNLKHKCFRNSLENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQC 324
            Q+F                                          K AL+ G        
Sbjct: 1287 QMF-----------------------------------------GKIALVDG-------- 1297

Query: 325  PEGYTCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQDYWENLY----------QQTLRAA 374
                   +I RN      +F TF  A L LFR  T + W+ +            ++  A 
Sbjct: 1298 ------TQINRN-----NNFQTFPQAVLLLFRCATGEAWQEILLACSYGKLCDPESDYAP 1346

Query: 375  GKTY-------MIFFVVVIFLGSFYLINLILAVV 401
            G+ Y         +F+    L +F +INL +AV+
Sbjct: 1347 GEEYTCGTNFAYYYFISFYMLCAFLVINLFVAVI 1380



 Score = 55.1 bits (131), Expect = 7e-07
 Identities = 70/338 (20%), Positives = 133/338 (39%), Gaps = 72/338 (21%)

Query: 122 ILVHSLFSMLIMCTILTNCIFMTM--NNPPDWTKNVE----YTFTGIYTFESLVKILARG 175
           I+   +F  L++  +  N + +    +N P W   ++         ++T E L+K+    
Sbjct: 428 IVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTRLQDIANRVLLSLFTTEMLMKM---- 483

Query: 176 FCVGEFTFLRDPWNWLDFVVIVFAYLTEF-VNLG-----NVSALRTFRVLRALKTISVIP 229
           + +G   +    +N  D  V+    L    V  G      +S LR  R+LR  K      
Sbjct: 484 YGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMTPLGISVLRCIRLLRIFKITKYWT 543

Query: 230 GLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETLESI 289
            L  +V +L+ S++ ++ +++L    + +FAL+G+QLF G       R   E+ E   S 
Sbjct: 544 SLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGG-------RYDFEDTEVRRS- 595

Query: 290 MNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSW 349
                            +    AL+  F   +G   E +T +       YG  S+     
Sbjct: 596 ---------------NFDNFPQALISVFQVLTG---EDWTSMMYNGIMAYGGPSY----- 632

Query: 350 AFLALFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAV-VAMAYEEQ 408
                                    G    I+F+++   G++ L+N+ LA+ V    E +
Sbjct: 633 ------------------------PGMLVCIYFIILFVCGNYILLNVFLAIAVDNLAEAE 668

Query: 409 NQANIEEAKQKELEFQQMLDRLKKEQEEAEAIAAAAAE 446
           +  + ++AK +E + ++M   L  + EE ++  A   E
Sbjct: 669 SLTSAQKAKAEEKKRRKMSKGLPDKSEEEKSTMAKKLE 706


>gi|192807298 calcium channel, voltage-dependent, L type, alpha 1D
            subunit isoform c [Homo sapiens]
          Length = 2137

 Score =  422 bits (1084), Expect = e-117
 Identities = 331/1138 (29%), Positives = 559/1138 (49%), Gaps = 160/1138 (14%)

Query: 739  ITICIVLNTLFMAMEHHPMTEEFKNVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWN 798
            + + + LNTL ++ EH+   +    +  I N V   +F  EM++K+ ++    YF   +N
Sbjct: 529  VIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFN 588

Query: 799  IFDSLIVTLSLVELFLADVE-----GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVG 853
             FD  +V   + E  L ++E     G+SV R  RLLR+FK+ + W +L+ L+  + NS+ 
Sbjct: 589  RFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMK 648

Query: 854  ALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVL 913
            ++ +L L+L + + IF+++GMQLFG  +        D+    R   ++F  + L VF++L
Sbjct: 649  SIASLLLLLFLFIIIFSLLGMQLFGGKFNF------DETQTKRSTFDNFPQALLTVFQIL 702

Query: 914  CGE-WIETMWDCMEVAG----QAMCLIVYMMVMVI-GNLVVLNLFLALLLSSFSSDNLTA 967
             GE W   M+D +   G      M + +Y +++ I GN ++LN+FLA+ +     DNL  
Sbjct: 703  TGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAV-----DNLA- 756

Query: 968  IEEDPDANNLQIAVTRIKKGINYVKQTLREFILKAFSKKPKISREIRQAEDLNTKKENYI 1027
                 DA +L  A           K+   E          K  ++I + E L  KK N  
Sbjct: 757  -----DAESLNTAQ----------KEEAEE----------KERKKIARKESLENKKNN-- 789

Query: 1028 SNHTLAEMSKGHNFLKEKDKISGFGSSVDKHLMEDSDGQSFIHNPSLTVTVPIAPGESDL 1087
                             K +++   +S +K  ++D   +    +P     VP+   E + 
Sbjct: 790  -----------------KPEVNQIANSDNKVTIDDYREEDEDKDPYPPCDVPVGEEEEEE 832

Query: 1088 ENMNAEELSSDSDSEYSKVRLNRSSSSECSTVDNPLPGEGEEAEAEPMNSDEPEACFTDG 1147
            E    E  +       S++ +    +        P+P   E +    ++   P       
Sbjct: 833  EEDEPEVPAGPRPRRISELNMKEKIA--------PIP---EGSAFFILSKTNP------- 874

Query: 1148 CVRRFSCCQVNIESGKGKIWWNIRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYIER 1207
                                  IR  C+K++ H  F + I++ I+LSS ALA ED  I  
Sbjct: 875  ----------------------IRVGCHKLINHHIFTNLILVFIMLSSAALAAEDP-IRS 911

Query: 1208 KKTIKIILEYADKIFTYIFILEMLLKWIAYG---YKTYFT-NAWCWLDFLIVDVSLVTLV 1263
                  IL Y D  FT IF +E+LLK   +G   +K  F  N +  LD L+V VSLV+  
Sbjct: 912  HSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFG 971

Query: 1264 ANTLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLI 1323
              +   S +  +K LR LR LRPLRA++R +G++ VV  +  AI +I N+++V  +   +
Sbjct: 972  IQS---SAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFM 1028

Query: 1324 FSIMGVNLFAGKFYECINTTDGSRFPASQVPNRSECFALMNVSQN-------VR---WKN 1373
            F+ +GV LF GKFY C   TD ++       N  EC  L  + ++       VR   W+N
Sbjct: 1029 FACIGVQLFKGKFYRC---TDEAK------SNPEECRGLFILYKDGDVDSPVVRERIWQN 1079

Query: 1374 LKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFG 1433
               NFDNV    ++L  V+TF+GW  ++Y A+DS   +  P Y + + + I+F+++II  
Sbjct: 1080 SDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIV 1139

Query: 1434 SFFTLNLFIGVIIDNFNQQ-KKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPR--PG 1490
            +FF +N+F+G +I  F +Q +K+    ++   + Q   Y A+K        +P+ R  P 
Sbjct: 1140 AFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEY-ALK-------ARPLRRYIPK 1191

Query: 1491 NKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTGE 1550
            N  Q   + +V +  F+  + VLI LN + + ++   QS+   + +  +N+VF  +FT E
Sbjct: 1192 NPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVE 1251

Query: 1551 CVLKLISLR-HYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRLARIGRI 1609
             VLK+I+ +   YF+  WN FD ++VI SI+ + L++   +   +       RL R+ R+
Sbjct: 1252 MVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADNSEESNRISITFFRLFRVMRL 1311

Query: 1610 LRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEDG--INDM 1667
            ++L+   +GIRTLL+  + S  AL  + LL+ ++ FIYA+ GM  F  V   D   IN  
Sbjct: 1312 VKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRN 1371

Query: 1668 FNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKK-VHPGSSVEGDCGNPSVGI 1726
             NF+TF  +++ LF+  T   W  ++   L  K   CDP+   +PG   E  CG+ +  I
Sbjct: 1372 NNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKL--CDPESDYNPGE--EYTCGS-NFAI 1426

Query: 1727 FYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWEKFDPDATQFI 1786
             YF+S+ ++   +++N+++AVI++NF   T +    L     + F  +W ++DP+A   I
Sbjct: 1427 VYFISFYMLCAFLIINLFVAVIMDNFDYLTRD-WSILGPHHLDEFKRIWSEYDPEAKGRI 1485

Query: 1787 EFSKLSDFAAALDPPLLIAK--PNKV---QLIAMDLPMVSGDRIHCLDILFAFTKRVL 1839
            +   +      + PPL   K  P++V   +L+AM++P+ S   +     LFA  +  L
Sbjct: 1486 KHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTAL 1543



 Score =  176 bits (447), Expect = 2e-43
 Identities = 167/684 (24%), Positives = 297/684 (43%), Gaps = 118/684 (17%)

Query: 1170 IRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYI----ERKKTIKIILEYADKIFTYI 1225
            IR+ C  IVE   F+ FI+L I  +  ALA   IYI    +   +    LE  +  F  I
Sbjct: 115  IRRACISIVEWKPFDIFILLAIFANCVALA---IYIPFPEDDSNSTNHNLEKVEYAFLII 171

Query: 1226 FILEMLLKWIAYGY----KTYFTNAWCWLDFLIVDVSLVTLVANTL-----------GYS 1270
            F +E  LK IAYG       Y  N W  LDF+IV V L +++   L           G S
Sbjct: 172  FTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKS 231

Query: 1271 DLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVN 1330
                +K+LR  R LRPLR +S    ++VV+N++I A+  ++++ L+ L   +I++I+G+ 
Sbjct: 232  GGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLE 291

Query: 1331 LFAGKFYECINTTDG------SRFPASQVPNRSECFALMNVSQN--VRWKNLKVNFDNVG 1382
            LF GK ++     D          P +   N  +C A     ++  V       NFDN  
Sbjct: 292  LFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFA 351

Query: 1383 LGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFI 1442
               L++ Q  T +GWT ++Y   D++  +           ++YFV  +IFGSFF LNL +
Sbjct: 352  FAMLTVFQCITMEGWTDVLYWMNDAMGFE---------LPWVYFVSLVIFGSFFVLNLVL 402

Query: 1443 GVIIDNFNQQKKKLGGQDIF--------MTEEQKKYYNAM----------KKLGSKKPQK 1484
            GV+   F+++++K   +  F        + E+ K Y + +          ++ G ++ ++
Sbjct: 403  GVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKR 462

Query: 1485 PIPRPGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQH-----------MT 1533
                P ++ +    + V+ +  +      +C  +    + +  +  +            +
Sbjct: 463  NTSMPTSETESVNTENVSGEGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKS 522

Query: 1534 EVLYWINVVFIIL------------------------------FTGECVLKLISL-RHYY 1562
               YW+ +V + L                              FT E ++K+ SL    Y
Sbjct: 523  VTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAY 582

Query: 1563 FTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRLARIGRILRLVKGAKGIRTL 1622
            F   +N FD  VV   I       L+E   +SP    V R  R+ RI ++ +    +  L
Sbjct: 583  FVSLFNRFDCFVVCGGITETI---LVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNL 639

Query: 1623 LFALMMSLPALFNIGLLLFLVMFIYAIFGMSNF-AYVKKEDGINDMFNFETFGNSMICLF 1681
            + +L+ S+ ++ ++ LLLFL + I+++ GM  F      ++       F+ F  +++ +F
Sbjct: 640  VASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVF 699

Query: 1682 QITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVV 1741
            QI T   W+ ++           D    + G S  G      +   YF+   I    +++
Sbjct: 700  QILTGEDWNAVM----------YDGIMAYGGPSSSG-----MIVCIYFIILFICGNYILL 744

Query: 1742 NMYIAVILENFSVATEESTEPLSE 1765
            N+++A+ ++N + A   +T    E
Sbjct: 745  NVFLAIAVDNLADAESLNTAQKEE 768



 Score =  152 bits (383), Expect = 4e-36
 Identities = 115/427 (26%), Positives = 199/427 (46%), Gaps = 72/427 (16%)

Query: 105 ALYMLSPFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTMNNP-PDWTKN--------V 155
           AL+ LS  +P+RR  I I+    F + I+  I  NC+ + +  P P+   N        V
Sbjct: 105 ALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKV 164

Query: 156 EYTFTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAY-------LTEFVNLG 208
           EY F  I+T E+ +KI+A G  +    ++R+ WN LDFV+++          LT+    G
Sbjct: 165 EYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGG 224

Query: 209 N----------VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSV 258
           N          V ALR FRVLR L+ +S +P L+ ++ ++I+++  L  + +L +F + +
Sbjct: 225 NHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIII 284

Query: 259 FALIGLQLFMGNLKHKCFRNSLENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFS 318
           +A+IGL+LF+G +   CF    +                        +   +D   C FS
Sbjct: 285 YAIIGLELFIGKMHKTCFFADSD------------------------IVAEEDPAPCAFS 320

Query: 319 TDSGQC-PEGYTCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQDYWEN-LYQQTLRAAGK 376
            +  QC   G  C      P+ G T+FD F++A L +F+ +T + W + LY        +
Sbjct: 321 GNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFE 380

Query: 377 TYMIFFVVVIFLGSFYLINLILAVVAMAY-EEQNQANIEEAKQKELEFQQMLDRLK---- 431
              ++FV ++  GSF+++NL+L V++  + +E+ +A      QK  E QQ+ + LK    
Sbjct: 381 LPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLD 440

Query: 432 -----------KEQEEAEA----IAAAAAEYTSIRRSRIMGLSESSSETSKLSSKSAKER 476
                       E+E  E      +   +E  S+    + G  E+      L    +K +
Sbjct: 441 WITQAEDIDPENEEEGGEEGKRNTSMPTSETESVNTENVSGEGENRGCCGSLCQAISKSK 500

Query: 477 RNRRKKK 483
            +RR ++
Sbjct: 501 LSRRWRR 507



 Score =  129 bits (324), Expect = 3e-29
 Identities = 86/295 (29%), Positives = 153/295 (51%), Gaps = 34/295 (11%)

Query: 691  ELEESRQKCPPWWYRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFM 750
            EL++++++C  +  +          +PY  KF    Y +   PF +  + + I+LNTL +
Sbjct: 1167 ELDKNQRQCVEYALKARPLRRYIPKNPYQYKFW---YVVNSSPF-EYMMFVLIMLNTLCL 1222

Query: 751  AMEHHPMTEEFKNVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLV 810
            AM+H+  ++ F + + I N+VFTG+F  EMVLK+IA  P  YF   WN FDSLIV  S++
Sbjct: 1223 AMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSII 1282

Query: 811  ELFLADVE--------GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVL 862
            ++ L++ +         ++  R FR++R+ KL      +  L+     S  AL  + L++
Sbjct: 1283 DVALSEADNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLI 1342

Query: 863  AIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGE-WIETM 921
            A++ FI+AV+GMQ+FGK       +IN +      +   F  + L++FR   GE W E M
Sbjct: 1343 AMLFFIYAVIGMQMFGKVAMRDNNQINRNN-----NFQTFPQAVLLLFRCATGEAWQEIM 1397

Query: 922  WDCME----------------VAGQAMCLIVYMMVMVIGNLVVLNLFLALLLSSF 960
              C+                   G    ++ ++   ++   +++NLF+A+++ +F
Sbjct: 1398 LACLPGKLCDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNF 1452



 Score =  110 bits (274), Expect = 2e-23
 Identities = 101/431 (23%), Positives = 194/431 (45%), Gaps = 63/431 (14%)

Query: 25   QRIAERKSKEPKEEKKDDDEEAPKPSSDL-------EAGKQLPFIYGDIPPGMVSEPLED 77
            ++IA ++S E K+  K +  +     + +       E   + P+   D+P G   E  E+
Sbjct: 775  KKIARKESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDKDPYPPCDVPVGEEEEEEEE 834

Query: 78   LDPYYAD---KKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRISIKILVHSLFSMLIMC 134
             +P        +    LN  + I       A ++LS  +P+R    K++ H +F+ LI+ 
Sbjct: 835  DEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILV 894

Query: 135  TILTNCIFMTMNNP---PDWTKNV----EYTFTGIYTFESLVKILARGFCVGEFTFLRDP 187
             I+ +   +   +P     +   +    +Y FT I+T E L+K+   G  + +  F R+ 
Sbjct: 895  FIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNY 954

Query: 188  WNWLDFVVIVFAYLTEFVNLGNVSA---LRTFRVLRALKTISVIPGLKTIVGALIQSVKK 244
            +N LD +V+  + ++  +    +S    LR  RVLR L+ I+   GLK +V  +  +++ 
Sbjct: 955  FNLLDMLVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRT 1014

Query: 245  LSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETLESIMNTLESEEDFRKYFY 304
            + ++MI+T     +FA IG+QLF G   ++C   +  N E    +            +  
Sbjct: 1015 IGNIMIVTTLLQFMFACIGVQLFKGKF-YRCTDEAKSNPEECRGL------------FIL 1061

Query: 305  YLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQDYWE 364
            Y +G  D+ +                 +I +N D+   +FD    A +ALF + T + W 
Sbjct: 1062 YKDGDVDSPV--------------VRERIWQNSDF---NFDNVLSAMMALFTVSTFEGWP 1104

Query: 365  NLYQQTLRAAGKT----------YMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANIE 414
             L  + + + G+             IFF++ I + +F+++N+ +  V + ++EQ +   +
Sbjct: 1105 ALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGE---K 1161

Query: 415  EAKQKELEFQQ 425
            E K  EL+  Q
Sbjct: 1162 EYKNCELDKNQ 1172



 Score =  101 bits (252), Expect = 6e-21
 Identities = 95/402 (23%), Positives = 176/402 (43%), Gaps = 63/402 (15%)

Query: 1092 AEELSSDSDSEYSKVRLNRSS--SSECSTVDNP-LPGEGEEAEAEPMNSDEPEACFTDGC 1148
            AE++  +++ E  +     +S  +SE  +V+   + GEGE                  GC
Sbjct: 445  AEDIDPENEEEGGEEGKRNTSMPTSETESVNTENVSGEGENR----------------GC 488

Query: 1149 VRRFSCCQVNIESGKGKIW--WNI--RKTCYKIVEHSWFESFIVLMILLSSGALAFEDIY 1204
                S CQ   +S   + W  WN   R+ C   V+   F   +++++ L++  ++ E  +
Sbjct: 489  CG--SLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSE--H 544

Query: 1205 IERKKTIKIILEYADKIFTYIFILEMLLKWIAYGYKTYFTNAWCWLDFLIVDVSLV-TLV 1263
              +   +  I + A+K+   +F  EML+K  + G + YF + +   D  +V   +  T++
Sbjct: 545  YNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETIL 604

Query: 1264 ANTLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLI 1323
                  S LG I   R +R LR  +    +  +  +V +L+ ++ SI ++LL+  +F +I
Sbjct: 605  VELEIMSPLG-ISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIII 663

Query: 1324 FSIMGVNLFAGKFYECINTTDGSRFPASQVPNRSECFALMNVSQNVRWKNLKVNFDNVGL 1383
            FS++G+ LF GKF           F  +Q    +                    FDN   
Sbjct: 664  FSLLGMQLFGGKF----------NFDETQTKRST--------------------FDNFPQ 693

Query: 1384 GYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIG 1443
              L++ Q+ T + W  +MY   D +     P     + + IYF++  I G++  LN+F+ 
Sbjct: 694  ALLTVFQILTGEDWNAVMY---DGIMAYGGPSSS-GMIVCIYFIILFICGNYILLNVFLA 749

Query: 1444 VIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKP 1485
            + +DN    +     Q     E+++K     + L +KK  KP
Sbjct: 750  IAVDNLADAESLNTAQKEEAEEKERKKIARKESLENKKNNKP 791



 Score = 84.7 bits (208), Expect = 8e-16
 Identities = 90/371 (24%), Positives = 149/371 (40%), Gaps = 83/371 (22%)

Query: 1463 MTEEQKKYYNAMKKLGSKKPQKPIPRP-----GNKIQGCIFDLVTNQAFDISIMVLICLN 1517
            +++ +++ Y   KK G+    +P          N I+     +V  + FDI I++ I  N
Sbjct: 80   LSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFAN 139

Query: 1518 MVTMMVE---KEGQSQHMTEVLYWINVVFIILFTGECVLKLIS---LRH--YYFTVGWNI 1569
             V + +     E  S      L  +   F+I+FT E  LK+I+   L H   Y   GWN+
Sbjct: 140  CVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNL 199

Query: 1570 FDFVVVIISIVGMFLADLI-ETYFVSPTL-------FRVIRLARIGRILRLVKGAKGIRT 1621
             DFV+VI+ +  + L  L  ET   + +         + +R  R+ R LRLV G   ++ 
Sbjct: 200  LDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQV 259

Query: 1622 LLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA-------------YVKKEDGINDMF 1668
            +L +++ ++  L +I LL+  V+ IYAI G+  F               V +ED     F
Sbjct: 260  VLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAF 319

Query: 1669 --------------------------NFETFGNSMICLFQITTSAGWDGLLAPILNSKPP 1702
                                      NF+ F  +M+ +FQ  T  GW  +L  +      
Sbjct: 320  SGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWM------ 373

Query: 1703 DCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENFSVATEESTEP 1762
                           D     +   YFVS +I     V+N+ + V+   FS   +E  + 
Sbjct: 374  --------------NDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFS---KEREKA 416

Query: 1763 LSEDDFEMFYE 1773
             +  DF+   E
Sbjct: 417  KARGDFQKLRE 427



 Score = 83.2 bits (204), Expect = 2e-15
 Identities = 73/298 (24%), Positives = 132/298 (44%), Gaps = 59/298 (19%)

Query: 723 KKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNV----LAIGNLVFTGIFAA 778
           + CI  +   PF D+ I + I  N + +A+ + P  E+  N     L      F  IF  
Sbjct: 117 RACISIVEWKPF-DIFILLAIFANCVALAI-YIPFPEDDSNSTNHNLEKVEYAFLIIFTV 174

Query: 779 EMVLKLIA----MDPYEYFQVGWNIFDSLIVTLSLVELFLA----DVEG----------- 819
           E  LK+IA    + P  Y + GWN+ D +IV + L  + L     + EG           
Sbjct: 175 ETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGF 234

Query: 820 -LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF- 877
            +  LR+FR+LR  +L    P+L +++  I  ++  L ++ L++  ++ I+A++G++LF 
Sbjct: 235 DVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFI 294

Query: 878 GKSYKECV-----------------------CKINDDCTLPRW--------HMNDFFHSF 906
           GK +K C                        C  N       W        + ++F  + 
Sbjct: 295 GKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAM 354

Query: 907 LIVFRVLCGE-WIETMWDCMEVAGQAMCLIVYMMVMVIGNLVVLNLFLALLLSSFSSD 963
           L VF+ +  E W + ++   +  G  +  + ++ +++ G+  VLNL L +L   FS +
Sbjct: 355 LTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKE 412



 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 38/157 (24%), Positives = 77/157 (49%), Gaps = 19/157 (12%)

Query: 126  SLFSMLIMCTILTNCIFMTMNNPP------DWTKNVEYTFTGIYTFESLVKILARGFCVG 179
            S F  ++   I+ N + + M +        D    +   FTG++T E ++K++A      
Sbjct: 1205 SPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIA----FK 1260

Query: 180  EFTFLRDPWNWLDFVVIVFAYL---------TEFVNLGNVSALRTFRVLRALKTISVIPG 230
               +  D WN  D ++++ + +         +E  N  +++  R FRV+R +K +S   G
Sbjct: 1261 PKGYFSDAWNTFDSLIVIGSIIDVALSEADNSEESNRISITFFRLFRVMRLVKLLSRGEG 1320

Query: 231  LKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 267
            ++T++   I+S + L  V +L      ++A+IG+Q+F
Sbjct: 1321 IRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMF 1357



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 71/333 (21%), Positives = 128/333 (38%), Gaps = 79/333 (23%)

Query: 128 FSMLIMCTILTNCIFMTMN--NPPDWTKNVE----YTFTGIYTFESLVKILARGFCVGEF 181
           F  L++  +  N + ++    N PDW   ++         ++T E LVK+    + +G  
Sbjct: 525 FYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKM----YSLGLQ 580

Query: 182 TFLRDPWNWLDFVVI-------VFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTI 234
            +    +N  D  V+       +   L     LG +S  R  R+LR  K       L  +
Sbjct: 581 AYFVSLFNRFDCFVVCGGITETILVELEIMSPLG-ISVFRCVRLLRIFKVTRHWTSLSNL 639

Query: 235 VGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETLESIMNTLE 294
           V +L+ S+K ++ +++L    + +F+L+G+QLF G         + +  +T  S  +   
Sbjct: 640 VASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKF-------NFDETQTKRSTFDNF- 691

Query: 295 SEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLAL 354
                            ALL  F   +G   E +  V       YG  S           
Sbjct: 692 ---------------PQALLTVFQILTG---EDWNAVMYDGIMAYGGPS----------- 722

Query: 355 FRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVA---MAYEEQNQA 411
                             ++G    I+F+++   G++ L+N+ LA+        E  N A
Sbjct: 723 ------------------SSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTA 764

Query: 412 NIEEAKQKE---LEFQQMLDRLKKEQEEAEAIA 441
             EEA++KE   +  ++ L+  K  + E   IA
Sbjct: 765 QKEEAEEKERKKIARKESLENKKNNKPEVNQIA 797


>gi|192807300 calcium channel, voltage-dependent, L type, alpha 1D
            subunit isoform b [Homo sapiens]
          Length = 2161

 Score =  416 bits (1069), Expect = e-115
 Identities = 335/1156 (28%), Positives = 563/1156 (48%), Gaps = 181/1156 (15%)

Query: 739  ITICIVLNTLFMAMEHHPMTEEFKNVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWN 798
            + + + LNTL ++ EH+   +    +  I N V   +F  EM++K+ ++    YF   +N
Sbjct: 529  VIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFN 588

Query: 799  IFDSLIVTLSLVELFLADVE-----GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVG 853
             FD  +V   + E  L ++E     G+SV R  RLLR+FK+ + W +L+ L+  + NS+ 
Sbjct: 589  RFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMK 648

Query: 854  ALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVL 913
            ++ +L L+L + + IF+++GMQLFG  +        D+    R   ++F  + L VF++L
Sbjct: 649  SIASLLLLLFLFIIIFSLLGMQLFGGKFNF------DETQTKRSTFDNFPQALLTVFQIL 702

Query: 914  CGE-WIETMWDCMEVAG----QAMCLIVYMMVMVI-GNLVVLNLFLALLLSSFSSDNLTA 967
             GE W   M+D +   G      M + +Y +++ I GN ++LN+FLA+ +     DNL  
Sbjct: 703  TGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAV-----DNLA- 756

Query: 968  IEEDPDANNLQIAVTRIKKGINYVKQTLREFILKAFSKKPKISREIRQAEDLNTKKENYI 1027
                 DA +L  A           K+   E          K  ++I + E L  KK N  
Sbjct: 757  -----DAESLNTAQ----------KEEAEE----------KERKKIARKESLENKKNN-- 789

Query: 1028 SNHTLAEMSKGHNFLKEKDKISGFGSSVDKHLMEDSDGQSFIHNPSLTVTVPIAPGESDL 1087
                             K +++   +S +K  ++D   +    +P     VP+   E + 
Sbjct: 790  -----------------KPEVNQIANSDNKVTIDDYREEDEDKDPYPPCDVPVGEEEEEE 832

Query: 1088 ENMNAEELSSDSDSEYSKVRLNRSSSSECSTVDNPLPGEGEEAEAEPMNSDEPEACFTDG 1147
            E    E  +       S++ +    +        P+P   E +    ++   P       
Sbjct: 833  EEDEPEVPAGPRPRRISELNMKEKIA--------PIP---EGSAFFILSKTNP------- 874

Query: 1148 CVRRFSCCQVNIESGKGKIWWNIRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYIER 1207
                                  IR  C+K++ H  F + I++ I+LSS ALA ED  I  
Sbjct: 875  ----------------------IRVGCHKLINHHIFTNLILVFIMLSSAALAAEDP-IRS 911

Query: 1208 KKTIKIILEYADKIFTYIFILEMLLKWIAYG---YKTYFT-NAWCWLDFLIVDVSLVTLV 1263
                  IL Y D  FT IF +E+LLK   +G   +K  F  N +  LD L+V VSLV+  
Sbjct: 912  HSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFG 971

Query: 1264 ANTLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLI 1323
              +   S +  +K LR LR LRPLRA++R +G++ VV  +  AI +I N+++V  +   +
Sbjct: 972  IQS---SAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFM 1028

Query: 1324 FSIMGVNLFAGKFYECINTTDGSRFPASQVPNRSECFALMNVSQN-------VR---WKN 1373
            F+ +GV LF GKFY C   TD ++       N  EC  L  + ++       VR   W+N
Sbjct: 1029 FACIGVQLFKGKFYRC---TDEAK------SNPEECRGLFILYKDGDVDSPVVRERIWQN 1079

Query: 1374 LKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFG 1433
               NFDNV    ++L  V+TF+GW  ++Y A+DS   +  P Y + + + I+F+++II  
Sbjct: 1080 SDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIV 1139

Query: 1434 SFFTLNLFIGVIIDNFNQQ-KKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPR--PG 1490
            +FF +N+F+G +I  F +Q +K+    ++   + Q   Y A+K        +P+ R  P 
Sbjct: 1140 AFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEY-ALK-------ARPLRRYIPK 1191

Query: 1491 NKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTGE 1550
            N  Q   + +V +  F+  + VLI LN + + ++   QS+   + +  +N+VF  +FT E
Sbjct: 1192 NPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVE 1251

Query: 1551 CVLKLISLR-HYYFTVGWNIFDFVVVIISIVGMFLADL------------------IETY 1591
             VLK+I+ +   YF+  WN FD ++VI SI+ + L++                    E+ 
Sbjct: 1252 MVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEESN 1311

Query: 1592 FVSPTLFRVIRLARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFG 1651
             +S T F   RL R+ R+++L+   +GIRTLL+  + S  AL  + LL+ ++ FIYA+ G
Sbjct: 1312 RISITFF---RLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIG 1368

Query: 1652 MSNFAYVKKEDG--INDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKK- 1708
            M  F  V   D   IN   NF+TF  +++ LF+  T   W  ++   L  K   CDP+  
Sbjct: 1369 MQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKL--CDPESD 1426

Query: 1709 VHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDF 1768
             +PG   E  CG+ +  I YF+S+ ++   +++N+++AVI++NF   T +    L     
Sbjct: 1427 YNPGE--EYTCGS-NFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRD-WSILGPHHL 1482

Query: 1769 EMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAK--PNKV---QLIAMDLPMVSGD 1823
            + F  +W ++DP+A   I+   +      + PPL   K  P++V   +L+AM++P+ S  
Sbjct: 1483 DEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDG 1542

Query: 1824 RIHCLDILFAFTKRVL 1839
             +     LFA  +  L
Sbjct: 1543 TVMFNATLFALVRTAL 1558



 Score =  176 bits (447), Expect = 2e-43
 Identities = 167/684 (24%), Positives = 297/684 (43%), Gaps = 118/684 (17%)

Query: 1170 IRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYI----ERKKTIKIILEYADKIFTYI 1225
            IR+ C  IVE   F+ FI+L I  +  ALA   IYI    +   +    LE  +  F  I
Sbjct: 115  IRRACISIVEWKPFDIFILLAIFANCVALA---IYIPFPEDDSNSTNHNLEKVEYAFLII 171

Query: 1226 FILEMLLKWIAYGY----KTYFTNAWCWLDFLIVDVSLVTLVANTL-----------GYS 1270
            F +E  LK IAYG       Y  N W  LDF+IV V L +++   L           G S
Sbjct: 172  FTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKS 231

Query: 1271 DLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVN 1330
                +K+LR  R LRPLR +S    ++VV+N++I A+  ++++ L+ L   +I++I+G+ 
Sbjct: 232  GGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLE 291

Query: 1331 LFAGKFYECINTTDG------SRFPASQVPNRSECFALMNVSQN--VRWKNLKVNFDNVG 1382
            LF GK ++     D          P +   N  +C A     ++  V       NFDN  
Sbjct: 292  LFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFA 351

Query: 1383 LGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFI 1442
               L++ Q  T +GWT ++Y   D++  +           ++YFV  +IFGSFF LNL +
Sbjct: 352  FAMLTVFQCITMEGWTDVLYWMNDAMGFE---------LPWVYFVSLVIFGSFFVLNLVL 402

Query: 1443 GVIIDNFNQQKKKLGGQDIF--------MTEEQKKYYNAM----------KKLGSKKPQK 1484
            GV+   F+++++K   +  F        + E+ K Y + +          ++ G ++ ++
Sbjct: 403  GVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKR 462

Query: 1485 PIPRPGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQH-----------MT 1533
                P ++ +    + V+ +  +      +C  +    + +  +  +            +
Sbjct: 463  NTSMPTSETESVNTENVSGEGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKS 522

Query: 1534 EVLYWINVVFIIL------------------------------FTGECVLKLISL-RHYY 1562
               YW+ +V + L                              FT E ++K+ SL    Y
Sbjct: 523  VTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAY 582

Query: 1563 FTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRLARIGRILRLVKGAKGIRTL 1622
            F   +N FD  VV   I       L+E   +SP    V R  R+ RI ++ +    +  L
Sbjct: 583  FVSLFNRFDCFVVCGGITETI---LVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNL 639

Query: 1623 LFALMMSLPALFNIGLLLFLVMFIYAIFGMSNF-AYVKKEDGINDMFNFETFGNSMICLF 1681
            + +L+ S+ ++ ++ LLLFL + I+++ GM  F      ++       F+ F  +++ +F
Sbjct: 640  VASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVF 699

Query: 1682 QITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVV 1741
            QI T   W+ ++           D    + G S  G      +   YF+   I    +++
Sbjct: 700  QILTGEDWNAVM----------YDGIMAYGGPSSSG-----MIVCIYFIILFICGNYILL 744

Query: 1742 NMYIAVILENFSVATEESTEPLSE 1765
            N+++A+ ++N + A   +T    E
Sbjct: 745  NVFLAIAVDNLADAESLNTAQKEE 768



 Score =  152 bits (383), Expect = 4e-36
 Identities = 115/427 (26%), Positives = 199/427 (46%), Gaps = 72/427 (16%)

Query: 105 ALYMLSPFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTMNNP-PDWTKN--------V 155
           AL+ LS  +P+RR  I I+    F + I+  I  NC+ + +  P P+   N        V
Sbjct: 105 ALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKV 164

Query: 156 EYTFTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAY-------LTEFVNLG 208
           EY F  I+T E+ +KI+A G  +    ++R+ WN LDFV+++          LT+    G
Sbjct: 165 EYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGG 224

Query: 209 N----------VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSV 258
           N          V ALR FRVLR L+ +S +P L+ ++ ++I+++  L  + +L +F + +
Sbjct: 225 NHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIII 284

Query: 259 FALIGLQLFMGNLKHKCFRNSLENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFS 318
           +A+IGL+LF+G +   CF    +                        +   +D   C FS
Sbjct: 285 YAIIGLELFIGKMHKTCFFADSD------------------------IVAEEDPAPCAFS 320

Query: 319 TDSGQC-PEGYTCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQDYWEN-LYQQTLRAAGK 376
            +  QC   G  C      P+ G T+FD F++A L +F+ +T + W + LY        +
Sbjct: 321 GNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFE 380

Query: 377 TYMIFFVVVIFLGSFYLINLILAVVAMAY-EEQNQANIEEAKQKELEFQQMLDRLK---- 431
              ++FV ++  GSF+++NL+L V++  + +E+ +A      QK  E QQ+ + LK    
Sbjct: 381 LPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLD 440

Query: 432 -----------KEQEEAEA----IAAAAAEYTSIRRSRIMGLSESSSETSKLSSKSAKER 476
                       E+E  E      +   +E  S+    + G  E+      L    +K +
Sbjct: 441 WITQAEDIDPENEEEGGEEGKRNTSMPTSETESVNTENVSGEGENRGCCGSLCQAISKSK 500

Query: 477 RNRRKKK 483
            +RR ++
Sbjct: 501 LSRRWRR 507



 Score =  123 bits (309), Expect = 2e-27
 Identities = 86/310 (27%), Positives = 153/310 (49%), Gaps = 49/310 (15%)

Query: 691  ELEESRQKCPPWWYRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFM 750
            EL++++++C  +  +          +PY  KF    Y +   PF +  + + I+LNTL +
Sbjct: 1167 ELDKNQRQCVEYALKARPLRRYIPKNPYQYKFW---YVVNSSPF-EYMMFVLIMLNTLCL 1222

Query: 751  AMEHHPMTEEFKNVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLV 810
            AM+H+  ++ F + + I N+VFTG+F  EMVLK+IA  P  YF   WN FDSLIV  S++
Sbjct: 1223 AMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSII 1282

Query: 811  ELFLADVE-----------------------GLSVLRSFRLLRVFKLAKSWPTLNMLIKI 847
            ++ L++ +                        ++  R FR++R+ KL      +  L+  
Sbjct: 1283 DVALSEADPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWT 1342

Query: 848  IGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFL 907
               S  AL  + L++A++ FI+AV+GMQ+FGK       +IN +      +   F  + L
Sbjct: 1343 FIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNN-----NFQTFPQAVL 1397

Query: 908  IVFRVLCGE-WIETMWDCME----------------VAGQAMCLIVYMMVMVIGNLVVLN 950
            ++FR   GE W E M  C+                   G    ++ ++   ++   +++N
Sbjct: 1398 LLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIIN 1457

Query: 951  LFLALLLSSF 960
            LF+A+++ +F
Sbjct: 1458 LFVAVIMDNF 1467



 Score =  110 bits (274), Expect = 2e-23
 Identities = 101/431 (23%), Positives = 194/431 (45%), Gaps = 63/431 (14%)

Query: 25   QRIAERKSKEPKEEKKDDDEEAPKPSSDL-------EAGKQLPFIYGDIPPGMVSEPLED 77
            ++IA ++S E K+  K +  +     + +       E   + P+   D+P G   E  E+
Sbjct: 775  KKIARKESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDKDPYPPCDVPVGEEEEEEEE 834

Query: 78   LDPYYAD---KKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRISIKILVHSLFSMLIMC 134
             +P        +    LN  + I       A ++LS  +P+R    K++ H +F+ LI+ 
Sbjct: 835  DEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILV 894

Query: 135  TILTNCIFMTMNNP---PDWTKNV----EYTFTGIYTFESLVKILARGFCVGEFTFLRDP 187
             I+ +   +   +P     +   +    +Y FT I+T E L+K+   G  + +  F R+ 
Sbjct: 895  FIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNY 954

Query: 188  WNWLDFVVIVFAYLTEFVNLGNVSA---LRTFRVLRALKTISVIPGLKTIVGALIQSVKK 244
            +N LD +V+  + ++  +    +S    LR  RVLR L+ I+   GLK +V  +  +++ 
Sbjct: 955  FNLLDMLVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRT 1014

Query: 245  LSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETLESIMNTLESEEDFRKYFY 304
            + ++MI+T     +FA IG+QLF G   ++C   +  N E    +            +  
Sbjct: 1015 IGNIMIVTTLLQFMFACIGVQLFKGKF-YRCTDEAKSNPEECRGL------------FIL 1061

Query: 305  YLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQDYWE 364
            Y +G  D+ +                 +I +N D+   +FD    A +ALF + T + W 
Sbjct: 1062 YKDGDVDSPV--------------VRERIWQNSDF---NFDNVLSAMMALFTVSTFEGWP 1104

Query: 365  NLYQQTLRAAGKT----------YMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANIE 414
             L  + + + G+             IFF++ I + +F+++N+ +  V + ++EQ +   +
Sbjct: 1105 ALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGE---K 1161

Query: 415  EAKQKELEFQQ 425
            E K  EL+  Q
Sbjct: 1162 EYKNCELDKNQ 1172



 Score =  101 bits (252), Expect = 6e-21
 Identities = 95/402 (23%), Positives = 176/402 (43%), Gaps = 63/402 (15%)

Query: 1092 AEELSSDSDSEYSKVRLNRSS--SSECSTVDNP-LPGEGEEAEAEPMNSDEPEACFTDGC 1148
            AE++  +++ E  +     +S  +SE  +V+   + GEGE                  GC
Sbjct: 445  AEDIDPENEEEGGEEGKRNTSMPTSETESVNTENVSGEGENR----------------GC 488

Query: 1149 VRRFSCCQVNIESGKGKIW--WNI--RKTCYKIVEHSWFESFIVLMILLSSGALAFEDIY 1204
                S CQ   +S   + W  WN   R+ C   V+   F   +++++ L++  ++ E  +
Sbjct: 489  CG--SLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSE--H 544

Query: 1205 IERKKTIKIILEYADKIFTYIFILEMLLKWIAYGYKTYFTNAWCWLDFLIVDVSLV-TLV 1263
              +   +  I + A+K+   +F  EML+K  + G + YF + +   D  +V   +  T++
Sbjct: 545  YNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETIL 604

Query: 1264 ANTLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLI 1323
                  S LG I   R +R LR  +    +  +  +V +L+ ++ SI ++LL+  +F +I
Sbjct: 605  VELEIMSPLG-ISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIII 663

Query: 1324 FSIMGVNLFAGKFYECINTTDGSRFPASQVPNRSECFALMNVSQNVRWKNLKVNFDNVGL 1383
            FS++G+ LF GKF           F  +Q    +                    FDN   
Sbjct: 664  FSLLGMQLFGGKF----------NFDETQTKRST--------------------FDNFPQ 693

Query: 1384 GYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIG 1443
              L++ Q+ T + W  +MY   D +     P     + + IYF++  I G++  LN+F+ 
Sbjct: 694  ALLTVFQILTGEDWNAVMY---DGIMAYGGPSSS-GMIVCIYFIILFICGNYILLNVFLA 749

Query: 1444 VIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKP 1485
            + +DN    +     Q     E+++K     + L +KK  KP
Sbjct: 750  IAVDNLADAESLNTAQKEEAEEKERKKIARKESLENKKNNKP 791



 Score = 84.7 bits (208), Expect = 8e-16
 Identities = 90/371 (24%), Positives = 149/371 (40%), Gaps = 83/371 (22%)

Query: 1463 MTEEQKKYYNAMKKLGSKKPQKPIPRP-----GNKIQGCIFDLVTNQAFDISIMVLICLN 1517
            +++ +++ Y   KK G+    +P          N I+     +V  + FDI I++ I  N
Sbjct: 80   LSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFAN 139

Query: 1518 MVTMMVE---KEGQSQHMTEVLYWINVVFIILFTGECVLKLIS---LRH--YYFTVGWNI 1569
             V + +     E  S      L  +   F+I+FT E  LK+I+   L H   Y   GWN+
Sbjct: 140  CVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNL 199

Query: 1570 FDFVVVIISIVGMFLADLI-ETYFVSPTL-------FRVIRLARIGRILRLVKGAKGIRT 1621
             DFV+VI+ +  + L  L  ET   + +         + +R  R+ R LRLV G   ++ 
Sbjct: 200  LDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQV 259

Query: 1622 LLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA-------------YVKKEDGINDMF 1668
            +L +++ ++  L +I LL+  V+ IYAI G+  F               V +ED     F
Sbjct: 260  VLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAF 319

Query: 1669 --------------------------NFETFGNSMICLFQITTSAGWDGLLAPILNSKPP 1702
                                      NF+ F  +M+ +FQ  T  GW  +L  +      
Sbjct: 320  SGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWM------ 373

Query: 1703 DCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENFSVATEESTEP 1762
                           D     +   YFVS +I     V+N+ + V+   FS   +E  + 
Sbjct: 374  --------------NDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFS---KEREKA 416

Query: 1763 LSEDDFEMFYE 1773
             +  DF+   E
Sbjct: 417  KARGDFQKLRE 427



 Score = 83.2 bits (204), Expect = 2e-15
 Identities = 73/298 (24%), Positives = 132/298 (44%), Gaps = 59/298 (19%)

Query: 723 KKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNV----LAIGNLVFTGIFAA 778
           + CI  +   PF D+ I + I  N + +A+ + P  E+  N     L      F  IF  
Sbjct: 117 RACISIVEWKPF-DIFILLAIFANCVALAI-YIPFPEDDSNSTNHNLEKVEYAFLIIFTV 174

Query: 779 EMVLKLIA----MDPYEYFQVGWNIFDSLIVTLSLVELFLA----DVEG----------- 819
           E  LK+IA    + P  Y + GWN+ D +IV + L  + L     + EG           
Sbjct: 175 ETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGF 234

Query: 820 -LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF- 877
            +  LR+FR+LR  +L    P+L +++  I  ++  L ++ L++  ++ I+A++G++LF 
Sbjct: 235 DVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFI 294

Query: 878 GKSYKECV-----------------------CKINDDCTLPRW--------HMNDFFHSF 906
           GK +K C                        C  N       W        + ++F  + 
Sbjct: 295 GKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAM 354

Query: 907 LIVFRVLCGE-WIETMWDCMEVAGQAMCLIVYMMVMVIGNLVVLNLFLALLLSSFSSD 963
           L VF+ +  E W + ++   +  G  +  + ++ +++ G+  VLNL L +L   FS +
Sbjct: 355 LTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKE 412



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 71/333 (21%), Positives = 128/333 (38%), Gaps = 79/333 (23%)

Query: 128 FSMLIMCTILTNCIFMTMN--NPPDWTKNVE----YTFTGIYTFESLVKILARGFCVGEF 181
           F  L++  +  N + ++    N PDW   ++         ++T E LVK+    + +G  
Sbjct: 525 FYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKM----YSLGLQ 580

Query: 182 TFLRDPWNWLDFVVI-------VFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTI 234
            +    +N  D  V+       +   L     LG +S  R  R+LR  K       L  +
Sbjct: 581 AYFVSLFNRFDCFVVCGGITETILVELEIMSPLG-ISVFRCVRLLRIFKVTRHWTSLSNL 639

Query: 235 VGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETLESIMNTLE 294
           V +L+ S+K ++ +++L    + +F+L+G+QLF G         + +  +T  S  +   
Sbjct: 640 VASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKF-------NFDETQTKRSTFDNF- 691

Query: 295 SEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLAL 354
                            ALL  F   +G   E +  V       YG  S           
Sbjct: 692 ---------------PQALLTVFQILTG---EDWNAVMYDGIMAYGGPS----------- 722

Query: 355 FRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVA---MAYEEQNQA 411
                             ++G    I+F+++   G++ L+N+ LA+        E  N A
Sbjct: 723 ------------------SSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTA 764

Query: 412 NIEEAKQKE---LEFQQMLDRLKKEQEEAEAIA 441
             EEA++KE   +  ++ L+  K  + E   IA
Sbjct: 765 QKEEAEEKERKKIARKESLENKKNNKPEVNQIA 797



 Score = 52.0 bits (123), Expect = 6e-06
 Identities = 41/172 (23%), Positives = 79/172 (45%), Gaps = 34/172 (19%)

Query: 126  SLFSMLIMCTILTNCIFMTMNNPP------DWTKNVEYTFTGIYTFESLVKILARGFCVG 179
            S F  ++   I+ N + + M +        D    +   FTG++T E ++K++A      
Sbjct: 1205 SPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIA----FK 1260

Query: 180  EFTFLRDPWNWLDFVVIVFAYL---------TEFVNL-------GN--------VSALRT 215
               +  D WN  D ++++ + +         TE  N+       GN        ++  R 
Sbjct: 1261 PKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEESNRISITFFRL 1320

Query: 216  FRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 267
            FRV+R +K +S   G++T++   I+S + L  V +L      ++A+IG+Q+F
Sbjct: 1321 FRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMF 1372


>gi|4502527 calcium channel, voltage-dependent, L type, alpha 1D
            subunit isoform a [Homo sapiens]
          Length = 2181

 Score =  416 bits (1069), Expect = e-115
 Identities = 335/1156 (28%), Positives = 563/1156 (48%), Gaps = 181/1156 (15%)

Query: 739  ITICIVLNTLFMAMEHHPMTEEFKNVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWN 798
            + + + LNTL ++ EH+   +    +  I N V   +F  EM++K+ ++    YF   +N
Sbjct: 549  VIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFN 608

Query: 799  IFDSLIVTLSLVELFLADVE-----GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVG 853
             FD  +V   + E  L ++E     G+SV R  RLLR+FK+ + W +L+ L+  + NS+ 
Sbjct: 609  RFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMK 668

Query: 854  ALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVL 913
            ++ +L L+L + + IF+++GMQLFG  +        D+    R   ++F  + L VF++L
Sbjct: 669  SIASLLLLLFLFIIIFSLLGMQLFGGKFNF------DETQTKRSTFDNFPQALLTVFQIL 722

Query: 914  CGE-WIETMWDCMEVAG----QAMCLIVYMMVMVI-GNLVVLNLFLALLLSSFSSDNLTA 967
             GE W   M+D +   G      M + +Y +++ I GN ++LN+FLA+ +     DNL  
Sbjct: 723  TGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAV-----DNLA- 776

Query: 968  IEEDPDANNLQIAVTRIKKGINYVKQTLREFILKAFSKKPKISREIRQAEDLNTKKENYI 1027
                 DA +L  A           K+   E          K  ++I + E L  KK N  
Sbjct: 777  -----DAESLNTAQ----------KEEAEE----------KERKKIARKESLENKKNN-- 809

Query: 1028 SNHTLAEMSKGHNFLKEKDKISGFGSSVDKHLMEDSDGQSFIHNPSLTVTVPIAPGESDL 1087
                             K +++   +S +K  ++D   +    +P     VP+   E + 
Sbjct: 810  -----------------KPEVNQIANSDNKVTIDDYREEDEDKDPYPPCDVPVGEEEEEE 852

Query: 1088 ENMNAEELSSDSDSEYSKVRLNRSSSSECSTVDNPLPGEGEEAEAEPMNSDEPEACFTDG 1147
            E    E  +       S++ +    +        P+P   E +    ++   P       
Sbjct: 853  EEDEPEVPAGPRPRRISELNMKEKIA--------PIP---EGSAFFILSKTNP------- 894

Query: 1148 CVRRFSCCQVNIESGKGKIWWNIRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYIER 1207
                                  IR  C+K++ H  F + I++ I+LSS ALA ED  I  
Sbjct: 895  ----------------------IRVGCHKLINHHIFTNLILVFIMLSSAALAAEDP-IRS 931

Query: 1208 KKTIKIILEYADKIFTYIFILEMLLKWIAYG---YKTYFT-NAWCWLDFLIVDVSLVTLV 1263
                  IL Y D  FT IF +E+LLK   +G   +K  F  N +  LD L+V VSLV+  
Sbjct: 932  HSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFG 991

Query: 1264 ANTLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLI 1323
              +   S +  +K LR LR LRPLRA++R +G++ VV  +  AI +I N+++V  +   +
Sbjct: 992  IQS---SAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFM 1048

Query: 1324 FSIMGVNLFAGKFYECINTTDGSRFPASQVPNRSECFALMNVSQN-------VR---WKN 1373
            F+ +GV LF GKFY C   TD ++       N  EC  L  + ++       VR   W+N
Sbjct: 1049 FACIGVQLFKGKFYRC---TDEAK------SNPEECRGLFILYKDGDVDSPVVRERIWQN 1099

Query: 1374 LKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFG 1433
               NFDNV    ++L  V+TF+GW  ++Y A+DS   +  P Y + + + I+F+++II  
Sbjct: 1100 SDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIV 1159

Query: 1434 SFFTLNLFIGVIIDNFNQQ-KKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPR--PG 1490
            +FF +N+F+G +I  F +Q +K+    ++   + Q   Y A+K        +P+ R  P 
Sbjct: 1160 AFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEY-ALK-------ARPLRRYIPK 1211

Query: 1491 NKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTGE 1550
            N  Q   + +V +  F+  + VLI LN + + ++   QS+   + +  +N+VF  +FT E
Sbjct: 1212 NPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVE 1271

Query: 1551 CVLKLISLR-HYYFTVGWNIFDFVVVIISIVGMFLADL------------------IETY 1591
             VLK+I+ +   YF+  WN FD ++VI SI+ + L++                    E+ 
Sbjct: 1272 MVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEESN 1331

Query: 1592 FVSPTLFRVIRLARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFG 1651
             +S T F   RL R+ R+++L+   +GIRTLL+  + S  AL  + LL+ ++ FIYA+ G
Sbjct: 1332 RISITFF---RLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIG 1388

Query: 1652 MSNFAYVKKEDG--INDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKK- 1708
            M  F  V   D   IN   NF+TF  +++ LF+  T   W  ++   L  K   CDP+  
Sbjct: 1389 MQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKL--CDPESD 1446

Query: 1709 VHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDF 1768
             +PG   E  CG+ +  I YF+S+ ++   +++N+++AVI++NF   T +    L     
Sbjct: 1447 YNPGE--EYTCGS-NFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRD-WSILGPHHL 1502

Query: 1769 EMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAK--PNKV---QLIAMDLPMVSGD 1823
            + F  +W ++DP+A   I+   +      + PPL   K  P++V   +L+AM++P+ S  
Sbjct: 1503 DEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDG 1562

Query: 1824 RIHCLDILFAFTKRVL 1839
             +     LFA  +  L
Sbjct: 1563 TVMFNATLFALVRTAL 1578



 Score =  153 bits (387), Expect = 1e-36
 Identities = 106/356 (29%), Positives = 179/356 (50%), Gaps = 53/356 (14%)

Query: 105 ALYMLSPFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTMNNP-PDWTKN--------V 155
           AL+ LS  +P+RR  I I+    F + I+  I  NC+ + +  P P+   N        V
Sbjct: 105 ALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKV 164

Query: 156 EYTFTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAY-------LTEFVNLG 208
           EY F  I+T E+ +KI+A G  +    ++R+ WN LDFV+++          LT+    G
Sbjct: 165 EYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGG 224

Query: 209 N----------VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSV 258
           N          V ALR FRVLR L+ +S +P L+ ++ ++I+++  L  + +L +F + +
Sbjct: 225 NHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIII 284

Query: 259 FALIGLQLFMGNLKHKCFRNSLENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFS 318
           +A+IGL+LF+G +   CF    +                        +   +D   C FS
Sbjct: 285 YAIIGLELFIGKMHKTCFFADSD------------------------IVAEEDPAPCAFS 320

Query: 319 TDSGQC-PEGYTCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKT 377
            +  QC   G  C      P+ G T+FD F++A L +F+ +T + W ++      A G  
Sbjct: 321 GNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAIGWE 380

Query: 378 Y-MIFFVVVIFLGSFYLINLILAVVAMAY-EEQNQANIEEAKQKELEFQQMLDRLK 431
           +  ++FV +I LGSF+++NL+L V++  + +E+ +A      QK  E QQ+ + LK
Sbjct: 381 WPWVYFVSLIILGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLK 436



 Score =  137 bits (345), Expect = 1e-31
 Identities = 102/327 (31%), Positives = 160/327 (48%), Gaps = 39/327 (11%)

Query: 1170 IRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYI----ERKKTIKIILEYADKIFTYI 1225
            IR+ C  IVE   F+ FI+L I  +  ALA   IYI    +   +    LE  +  F  I
Sbjct: 115  IRRACISIVEWKPFDIFILLAIFANCVALA---IYIPFPEDDSNSTNHNLEKVEYAFLII 171

Query: 1226 FILEMLLKWIAYGY----KTYFTNAWCWLDFLIVDVSLVTLVANTL-----------GYS 1270
            F +E  LK IAYG       Y  N W  LDF+IV V L +++   L           G S
Sbjct: 172  FTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKS 231

Query: 1271 DLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVN 1330
                +K+LR  R LRPLR +S    ++VV+N++I A+  ++++ L+ L   +I++I+G+ 
Sbjct: 232  GGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLE 291

Query: 1331 LFAGKFYECINTTDG------SRFPASQVPNRSECFALMNVSQN--VRWKNLKVNFDNVG 1382
            LF GK ++     D          P +   N  +C A     ++  V       NFDN  
Sbjct: 292  LFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFA 351

Query: 1383 LGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFI 1442
               L++ Q  T +GWT ++Y   D++  +         + ++YFV  II GSFF LNL +
Sbjct: 352  FAMLTVFQCITMEGWTDVLYWVNDAIGWE---------WPWVYFVSLIILGSFFVLNLVL 402

Query: 1443 GVIIDNFNQQKKKLGGQDIFMTEEQKK 1469
            GV+   F+++++K   +  F    +K+
Sbjct: 403  GVLSGEFSKEREKAKARGDFQKLREKQ 429



 Score =  123 bits (309), Expect = 2e-27
 Identities = 86/310 (27%), Positives = 153/310 (49%), Gaps = 49/310 (15%)

Query: 691  ELEESRQKCPPWWYRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFM 750
            EL++++++C  +  +          +PY  KF    Y +   PF +  + + I+LNTL +
Sbjct: 1187 ELDKNQRQCVEYALKARPLRRYIPKNPYQYKFW---YVVNSSPF-EYMMFVLIMLNTLCL 1242

Query: 751  AMEHHPMTEEFKNVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLV 810
            AM+H+  ++ F + + I N+VFTG+F  EMVLK+IA  P  YF   WN FDSLIV  S++
Sbjct: 1243 AMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSII 1302

Query: 811  ELFLADVE-----------------------GLSVLRSFRLLRVFKLAKSWPTLNMLIKI 847
            ++ L++ +                        ++  R FR++R+ KL      +  L+  
Sbjct: 1303 DVALSEADPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWT 1362

Query: 848  IGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFL 907
               S  AL  + L++A++ FI+AV+GMQ+FGK       +IN +      +   F  + L
Sbjct: 1363 FIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNN-----NFQTFPQAVL 1417

Query: 908  IVFRVLCGE-WIETMWDCME----------------VAGQAMCLIVYMMVMVIGNLVVLN 950
            ++FR   GE W E M  C+                   G    ++ ++   ++   +++N
Sbjct: 1418 LLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIIN 1477

Query: 951  LFLALLLSSF 960
            LF+A+++ +F
Sbjct: 1478 LFVAVIMDNF 1487



 Score =  110 bits (274), Expect = 2e-23
 Identities = 101/431 (23%), Positives = 194/431 (45%), Gaps = 63/431 (14%)

Query: 25   QRIAERKSKEPKEEKKDDDEEAPKPSSDL-------EAGKQLPFIYGDIPPGMVSEPLED 77
            ++IA ++S E K+  K +  +     + +       E   + P+   D+P G   E  E+
Sbjct: 795  KKIARKESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDKDPYPPCDVPVGEEEEEEEE 854

Query: 78   LDPYYAD---KKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRISIKILVHSLFSMLIMC 134
             +P        +    LN  + I       A ++LS  +P+R    K++ H +F+ LI+ 
Sbjct: 855  DEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILV 914

Query: 135  TILTNCIFMTMNNP---PDWTKNV----EYTFTGIYTFESLVKILARGFCVGEFTFLRDP 187
             I+ +   +   +P     +   +    +Y FT I+T E L+K+   G  + +  F R+ 
Sbjct: 915  FIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNY 974

Query: 188  WNWLDFVVIVFAYLTEFVNLGNVSA---LRTFRVLRALKTISVIPGLKTIVGALIQSVKK 244
            +N LD +V+  + ++  +    +S    LR  RVLR L+ I+   GLK +V  +  +++ 
Sbjct: 975  FNLLDMLVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRT 1034

Query: 245  LSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETLESIMNTLESEEDFRKYFY 304
            + ++MI+T     +FA IG+QLF G   ++C   +  N E    +            +  
Sbjct: 1035 IGNIMIVTTLLQFMFACIGVQLFKGKF-YRCTDEAKSNPEECRGL------------FIL 1081

Query: 305  YLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQDYWE 364
            Y +G  D+ +                 +I +N D+   +FD    A +ALF + T + W 
Sbjct: 1082 YKDGDVDSPV--------------VRERIWQNSDF---NFDNVLSAMMALFTVSTFEGWP 1124

Query: 365  NLYQQTLRAAGKT----------YMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANIE 414
             L  + + + G+             IFF++ I + +F+++N+ +  V + ++EQ +   +
Sbjct: 1125 ALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGE---K 1181

Query: 415  EAKQKELEFQQ 425
            E K  EL+  Q
Sbjct: 1182 EYKNCELDKNQ 1192



 Score = 97.4 bits (241), Expect = 1e-19
 Identities = 77/321 (23%), Positives = 145/321 (45%), Gaps = 40/321 (12%)

Query: 1168 WNI--RKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYI 1225
            WN   R+ C   V+   F   +++++ L++  ++ E  +  +   +  I + A+K+   +
Sbjct: 528  WNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSE--HYNQPDWLTQIQDIANKVLLAL 585

Query: 1226 FILEMLLKWIAYGYKTYFTNAWCWLDFLIVDVSLV-TLVANTLGYSDLGPIKSLRTLRAL 1284
            F  EML+K  + G + YF + +   D  +V   +  T++      S LG I   R +R L
Sbjct: 586  FTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLG-ISVFRCVRLL 644

Query: 1285 RPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTD 1344
            R  +    +  +  +V +L+ ++ SI ++LL+  +F +IFS++G+ LF GKF        
Sbjct: 645  RIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKF-------- 696

Query: 1345 GSRFPASQVPNRSECFALMNVSQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAA 1404
               F  +Q    +                    FDN     L++ Q+ T + W  +MY  
Sbjct: 697  --NFDETQTKRST--------------------FDNFPQALLTVFQILTGEDWNAVMY-- 732

Query: 1405 VDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMT 1464
             D +     P     + + IYF++  I G++  LN+F+ + +DN    +     Q     
Sbjct: 733  -DGIMAYGGPSSS-GMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAE 790

Query: 1465 EEQKKYYNAMKKLGSKKPQKP 1485
            E+++K     + L +KK  KP
Sbjct: 791  EKERKKIARKESLENKKNNKP 811



 Score = 85.9 bits (211), Expect = 4e-16
 Identities = 92/375 (24%), Positives = 152/375 (40%), Gaps = 91/375 (24%)

Query: 1463 MTEEQKKYYNAMKKLGSKKPQKPIPRP-----GNKIQGCIFDLVTNQAFDISIMVLICLN 1517
            +++ +++ Y   KK G+    +P          N I+     +V  + FDI I++ I  N
Sbjct: 80   LSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFAN 139

Query: 1518 MVTMMVE---KEGQSQHMTEVLYWINVVFIILFTGECVLKLIS---LRH--YYFTVGWNI 1569
             V + +     E  S      L  +   F+I+FT E  LK+I+   L H   Y   GWN+
Sbjct: 140  CVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNL 199

Query: 1570 FDFVVVIISIVGMFLADLI-ETYFVSPTL-------FRVIRLARIGRILRLVKGAKGIRT 1621
             DFV+VI+ +  + L  L  ET   + +         + +R  R+ R LRLV G   ++ 
Sbjct: 200  LDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQV 259

Query: 1622 LLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA-------------YVKKEDGINDMF 1668
            +L +++ ++  L +I LL+  V+ IYAI G+  F               V +ED     F
Sbjct: 260  VLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAF 319

Query: 1669 --------------------------NFETFGNSMICLFQITTSAGWDGLLAPILNSKPP 1702
                                      NF+ F  +M+ +FQ  T  GW  +L  +      
Sbjct: 320  SGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWV------ 373

Query: 1703 DCDPKKVHPGSSVEGDCGNPSVG----IFYFVSYIIISFLVVVNMYIAVILENFSVATEE 1758
                              N ++G      YFVS II+    V+N+ + V+   FS   +E
Sbjct: 374  ------------------NDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSGEFS---KE 412

Query: 1759 STEPLSEDDFEMFYE 1773
              +  +  DF+   E
Sbjct: 413  REKAKARGDFQKLRE 427



 Score = 83.2 bits (204), Expect = 2e-15
 Identities = 73/298 (24%), Positives = 132/298 (44%), Gaps = 59/298 (19%)

Query: 723 KKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNV----LAIGNLVFTGIFAA 778
           + CI  +   PF D+ I + I  N + +A+ + P  E+  N     L      F  IF  
Sbjct: 117 RACISIVEWKPF-DIFILLAIFANCVALAI-YIPFPEDDSNSTNHNLEKVEYAFLIIFTV 174

Query: 779 EMVLKLIA----MDPYEYFQVGWNIFDSLIVTLSLVELFLA----DVEG----------- 819
           E  LK+IA    + P  Y + GWN+ D +IV + L  + L     + EG           
Sbjct: 175 ETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGF 234

Query: 820 -LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF- 877
            +  LR+FR+LR  +L    P+L +++  I  ++  L ++ L++  ++ I+A++G++LF 
Sbjct: 235 DVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFI 294

Query: 878 GKSYKECV-----------------------CKINDDCTLPRW--------HMNDFFHSF 906
           GK +K C                        C  N       W        + ++F  + 
Sbjct: 295 GKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAM 354

Query: 907 LIVFRVLCGE-WIETMWDCMEVAGQAMCLIVYMMVMVIGNLVVLNLFLALLLSSFSSD 963
           L VF+ +  E W + ++   +  G     + ++ ++++G+  VLNL L +L   FS +
Sbjct: 355 LTVFQCITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSGEFSKE 412



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 71/333 (21%), Positives = 128/333 (38%), Gaps = 79/333 (23%)

Query: 128 FSMLIMCTILTNCIFMTMN--NPPDWTKNVE----YTFTGIYTFESLVKILARGFCVGEF 181
           F  L++  +  N + ++    N PDW   ++         ++T E LVK+    + +G  
Sbjct: 545 FYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKM----YSLGLQ 600

Query: 182 TFLRDPWNWLDFVVI-------VFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTI 234
            +    +N  D  V+       +   L     LG +S  R  R+LR  K       L  +
Sbjct: 601 AYFVSLFNRFDCFVVCGGITETILVELEIMSPLG-ISVFRCVRLLRIFKVTRHWTSLSNL 659

Query: 235 VGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETLESIMNTLE 294
           V +L+ S+K ++ +++L    + +F+L+G+QLF G         + +  +T  S  +   
Sbjct: 660 VASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKF-------NFDETQTKRSTFDNF- 711

Query: 295 SEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLAL 354
                            ALL  F   +G   E +  V       YG  S           
Sbjct: 712 ---------------PQALLTVFQILTG---EDWNAVMYDGIMAYGGPS----------- 742

Query: 355 FRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVA---MAYEEQNQA 411
                             ++G    I+F+++   G++ L+N+ LA+        E  N A
Sbjct: 743 ------------------SSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTA 784

Query: 412 NIEEAKQKE---LEFQQMLDRLKKEQEEAEAIA 441
             EEA++KE   +  ++ L+  K  + E   IA
Sbjct: 785 QKEEAEEKERKKIARKESLENKKNNKPEVNQIA 817



 Score = 52.0 bits (123), Expect = 6e-06
 Identities = 41/172 (23%), Positives = 79/172 (45%), Gaps = 34/172 (19%)

Query: 126  SLFSMLIMCTILTNCIFMTMNNPP------DWTKNVEYTFTGIYTFESLVKILARGFCVG 179
            S F  ++   I+ N + + M +        D    +   FTG++T E ++K++A      
Sbjct: 1225 SPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIA----FK 1280

Query: 180  EFTFLRDPWNWLDFVVIVFAYL---------TEFVNL-------GN--------VSALRT 215
               +  D WN  D ++++ + +         TE  N+       GN        ++  R 
Sbjct: 1281 PKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEESNRISITFFRL 1340

Query: 216  FRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 267
            FRV+R +K +S   G++T++   I+S + L  V +L      ++A+IG+Q+F
Sbjct: 1341 FRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMF 1392


>gi|51093859 calcium channel, voltage-dependent, T type, alpha 1I
            subunit isoform b [Homo sapiens]
          Length = 2188

 Score =  342 bits (877), Expect = 2e-93
 Identities = 209/625 (33%), Positives = 345/625 (55%), Gaps = 39/625 (6%)

Query: 1171 RKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILEM 1230
            R  C  I+ H  F+  ++  I L+   +A E   IE   T +I L  ++ IFT IF+ EM
Sbjct: 1125 RVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEM 1184

Query: 1231 LLKWIA----YGYKTYFTNAWCWLDFLIVDVSLVTLV---ANTLGYSDLGPIKSLRTLRA 1283
             LK ++    +G + Y  ++W  LD  +V VS++ +V   A+  G   LG ++ LR LR 
Sbjct: 1185 TLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRT 1244

Query: 1284 LRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTT 1343
            LRPLR +SR  G+++VV  LI ++  I N++L+C  F++IF I+GV LF GKFY C+   
Sbjct: 1245 LRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVD 1304

Query: 1344 DGSRFPASQVPNRSECFALMNVSQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYA 1403
                     + NRS+C A      N RW + K NFDN+G   +SL  +A+  GW  IMY 
Sbjct: 1305 ------TRNITNRSDCMAA-----NYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYN 1353

Query: 1404 AVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFM 1463
             +D+V VD+QP   ++ +M +YF+ F++  SFF LN+F+GV+++NF++ ++    ++   
Sbjct: 1354 GLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARR 1413

Query: 1464 TEEQKKYYNAMKKLGSKKPQKPIPRPGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMV 1523
             EE  K    ++K   K  + P        +  I  + T+   DI I  +ICLN+VTM +
Sbjct: 1414 REE--KRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSL 1471

Query: 1524 EKEGQSQHMTEVLYWINVVFIILFTGECVLKLISL-RHYYFTVGWNIFDFVVVIISIVGM 1582
            E   Q   +   L + N +F  +F  E VLKL++     +F   WN  D  +V++S++G+
Sbjct: 1472 EHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGI 1531

Query: 1583 FL--ADLIETYFVSPTLFRVIRLARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLL 1640
             L   ++     ++PT+ R++R+ RI R+L+L+K A G+R LL  ++ +LP + N+GLL 
Sbjct: 1532 TLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLF 1591

Query: 1641 FLVMFIYAIFGMSNFAYVKKED-----GINDMFNFETFGNSMICLFQITTSAGWDGLLAP 1695
             L+ FIYA  G+  F  +   D     G++    FE FG + + LFQ++T   W+G++  
Sbjct: 1592 MLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKD 1651

Query: 1696 ILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENFSVA 1755
             L     DC   +    SS++       V   YFVS+++ +  V++N+ +AV++++   +
Sbjct: 1652 TLR----DCTHDERSCLSSLQ------FVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDS 1701

Query: 1756 TEESTEPLSEDDFEMFYEVWEKFDP 1780
             +E+ E  +E D E+  E+     P
Sbjct: 1702 NKEAQED-AEMDAELELEMAHGLGP 1725



 Score =  151 bits (381), Expect = 7e-36
 Identities = 86/272 (31%), Positives = 155/272 (56%), Gaps = 9/272 (3%)

Query: 712 IWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAIGNLV 771
           +W C   W + +  +  IV   + +  I + I++NT+ M +EHH   EE  N+L I N+V
Sbjct: 584 VWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVV 643

Query: 772 FTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADVEGLSVLRSFRLLRV 831
           FT +FA EM+LKL A   ++Y +  +NIFDS+IV +S+ E+      GLSVLR+FRLLRV
Sbjct: 644 FTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQADGGLSVLRTFRLLRV 703

Query: 832 FKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDD 891
            KL +  P L   + ++  ++  +    ++L + +FIF+++GM +FG  +     + +  
Sbjct: 704 LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFS---LRTDTG 760

Query: 892 CTLP-RWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQAMCLIVYMMVMVIGNLVVL 949
            T+P R + +    + + VF++L  E W   +++ M  +      + ++ +M  GN V+ 
Sbjct: 761 DTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGM-ASTSPWASLYFVALMTFGNYVLF 819

Query: 950 NLFLALLLSSFSSD---NLTAIEEDPDANNLQ 978
           NL +A+L+  F ++   N +  +ED  ++N++
Sbjct: 820 NLLVAILVEGFQAEGDANRSYSDEDQSSSNIE 851



 Score =  132 bits (333), Expect = 3e-30
 Identities = 107/391 (27%), Positives = 182/391 (46%), Gaps = 66/391 (16%)

Query: 67  PPGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRISIKILVHS 126
           PPG+  EPL+  DP+                    A  A + L   +  R   IK++ + 
Sbjct: 35  PPGL-EEPLDGADPHVPHPDL--------------APIAFFCLRQTTSPRNWCIKMVCNP 79

Query: 127 LFSMLIMCTILTNCIFMTMNNP-------PDWTKNVEYTFTGIYTF---ESLVKILARGF 176
            F  + M  IL NC+ + M  P        D  K ++     I+ F   E ++K++A G 
Sbjct: 80  WFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGI 139

Query: 177 CVGEFTFLRDPWNWLDFVVIVFAYLTEFVNLGNV--SALRTFRVLRALKTISVIPGLKTI 234
             G+  +L D WN LDF +++   +   ++L N+  SA+RT RVLR LK I+ +P ++ +
Sbjct: 140 -FGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRIL 198

Query: 235 VGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETLE---SIMN 291
           V  L+ ++  L +V++L  F   +F +IG+QL+ G L+++CF   LE N T++   ++  
Sbjct: 199 VNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCF---LEENFTIQGDVALPP 255

Query: 292 TLESEEDFRKYFYYLEGSKDALL--------------CGFSTD--------------SGQ 323
             + EED    F       + ++              C  S D              SG 
Sbjct: 256 YYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDVYDFGAGRQDLNASGL 315

Query: 324 CPEG---YTCVKIG-RNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYM 379
           C      Y   + G  NP  G  +FD   +A++ +F+++T + W  +    + A      
Sbjct: 316 CVNWNRYYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNF 375

Query: 380 IFFVVVIFLGSFYLINLILAVVAMAYEEQNQ 410
           I+F+++I +GSF++INL L V+A  + E  Q
Sbjct: 376 IYFILLIIVGSFFMINLCLVVIATQFSETKQ 406



 Score =  126 bits (317), Expect = 2e-28
 Identities = 111/413 (26%), Positives = 186/413 (45%), Gaps = 102/413 (24%)

Query: 1133 EPMNSDEPEACFTDGCVRRFSCCQVNIESGKGKIWWNIRKTCYKIVEHSWFESFIVLMIL 1192
            EP++  +P     D     F C +              R  C K+V + WFE   +L+IL
Sbjct: 40   EPLDGADPHVPHPDLAPIAFFCLRQTTSP---------RNWCIKMVCNPWFECVSMLVIL 90

Query: 1193 LSSGALAFE------DIYIERKKTIKIILEYADKIFTYIFILEMLLKWIA---YGYKTYF 1243
            L+   L         D   +R K +++   + D IF + F +EM+LK +A   +G K Y 
Sbjct: 91   LNCVTLGMYQPCDDMDCLSDRCKILQV---FDDFIFIF-FAMEMVLKMVALGIFGKKCYL 146

Query: 1244 TNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNAL 1303
             + W  LDF IV   +  +V  +L   ++  + ++RT+R LRPL+A++R   MR++VN L
Sbjct: 147  GDTWNRLDFFIV---MAGMVEYSLDLQNIN-LSAIRTVRVLRPLKAINRVPSMRILVNLL 202

Query: 1304 IGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG---------------------KFYE---- 1338
            +  +P + NVLL+C   + IF I+GV L+AG                      +Y+    
Sbjct: 203  LDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEED 262

Query: 1339 ------CINTTDGSRFPASQVP-----NRSECFALMNV------SQNVRWKNLKVNFDNV 1381
                  C  + D       ++P      R  C +  +V       Q++    L VN++  
Sbjct: 263  DEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDVYDFGAGRQDLNASGLCVNWNRY 322

Query: 1382 -------------------GLGY--LSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSL 1420
                                +GY  + + QV T +GW  IMY  +D+          +S 
Sbjct: 323  YNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDA----------HSF 372

Query: 1421 YMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNA 1473
            Y +IYF++ II GSFF +NL + VI   F++ K++   +   M E++++Y ++
Sbjct: 373  YNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---EHRLMLEQRQRYLSS 422



 Score =  114 bits (284), Expect = 1e-24
 Identities = 87/364 (23%), Positives = 159/364 (43%), Gaps = 73/364 (20%)

Query: 105  ALYMLSPFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVE-------- 156
            ++Y+ SP +  R +   I+ H LF  +++  I  NCI + +  P     + E        
Sbjct: 1114 SVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSN 1173

Query: 157  YTFTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVNL--------- 207
            Y FT I+  E  +K+++ G   GE  +LR  WN LD  ++  + +   V+L         
Sbjct: 1174 YIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKIL 1233

Query: 208  GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 267
            G +  LR  R LR L+ IS  PGLK +V  LI S+K + +++++      +F ++G+QLF
Sbjct: 1234 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLF 1293

Query: 268  MGNLKHKCFRNSLENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEG 327
             G                                 FY+  G           D+      
Sbjct: 1294 KGK--------------------------------FYHCLG----------VDTRNITNR 1311

Query: 328  YTCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQDYWENLY----------QQTLRAAGKT 377
              C+       +   +FD    A ++LF L ++D W N+           QQ +      
Sbjct: 1312 SDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPW 1371

Query: 378  YMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQ-ANIEEAKQKELEFQQMLDRLKKEQEE 436
             +++F+  + + SF+++N+ + VV   + +  Q    EEA+++E   ++ L RL+K++ +
Sbjct: 1372 MLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRRE---EKRLRRLEKKRRK 1428

Query: 437  AEAI 440
            A+ +
Sbjct: 1429 AQRL 1432



 Score =  107 bits (266), Expect = 2e-22
 Identities = 82/309 (26%), Positives = 147/309 (47%), Gaps = 34/309 (11%)

Query: 690  EELEESRQKCPPWWYRFAHKFLIWNCSPYWIKF---KKCIYFIVMDPFVDLAITICIVLN 746
            +E EE+R++      R   K       PY+  +   +  I+ +    ++D+ IT  I LN
Sbjct: 1406 QEAEEARRREEKRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLN 1465

Query: 747  TLFMAMEHHPMTEEFKNVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVT 806
             + M++EH+      +  L   N +FT +F  E VLKL+A     +F+  WN  D  IV 
Sbjct: 1466 VVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVL 1525

Query: 807  LSLVELFLADVE----------GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALG 856
            LS++ + L ++E           + ++R  R+ RV KL K    +  L+  +  ++  +G
Sbjct: 1526 LSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVG 1585

Query: 857  NLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWH--MNDFFHSFLIVFRVLC 914
            NL L+  ++ FI+A +G++LFGK     VC   + C     H    +F  +FL +F+V  
Sbjct: 1586 NLGLLFMLLFFIYAALGVELFGK----LVCNDENPCEGMSRHATFENFGMAFLTLFQVST 1641

Query: 915  GE-W----IETMWDCMEVAGQAMCL--------IVYMMVMVIGNLVVLNLFLALLLSSFS 961
            G+ W     +T+ DC     +  CL        + ++  ++    V++N+ +A+L+    
Sbjct: 1642 GDNWNGIMKDTLRDCTH--DERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLD 1699

Query: 962  SDNLTAIEE 970
              N  A E+
Sbjct: 1700 DSNKEAQED 1708



 Score =  106 bits (265), Expect = 2e-22
 Identities = 89/357 (24%), Positives = 163/357 (45%), Gaps = 57/357 (15%)

Query: 1096 SSDSDSEYSKVRLNRSSSSECSTVDNPLPGEGEEAEAEPMNSDEPEACFTDGCVRRFSCC 1155
            S+DS  E S    + SS+      D       E+  +  +  +E E    DG V  + C 
Sbjct: 534  STDSGQEGSG---SGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQADGAV--WLC- 587

Query: 1156 QVNIESGKGKIWWNIRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIIL 1215
                    G +W   R     IV+  +F   I++ IL+++ ++  E  + E+ + +  IL
Sbjct: 588  --------GDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIE--HHEQPEELTNIL 637

Query: 1216 EYADKIFTYIFILEMLLKWIAYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPI 1275
            E  + +FT +F LEM+LK  A+G   Y  N +   D +IV +S+  +V    G +D G +
Sbjct: 638  EICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIV----GQAD-GGL 692

Query: 1276 KSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK 1335
              LRT R LR L+ +     +R  +  L+  + ++    ++ ++F  IFSI+G+++F  K
Sbjct: 693  SVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCK 752

Query: 1336 FYECINTTDGSRFPASQVPNRSECFALMNVSQNVRWKNLKVNFDNVGLGYLSLLQVATFK 1395
            F    +T D        VP+R                    NFD++    +++ Q+ T +
Sbjct: 753  FSLRTDTGD-------TVPDRK-------------------NFDSLLWAIVTVFQILTQE 786

Query: 1396 GWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQ 1452
             W +++Y  + S           S +  +YFV  + FG++   NL + ++++ F  +
Sbjct: 787  DWNVVLYNGMAST----------SPWASLYFVALMTFGNYVLFNLLVAILVEGFQAE 833



 Score =  102 bits (254), Expect = 4e-21
 Identities = 73/291 (25%), Positives = 136/291 (46%), Gaps = 38/291 (13%)

Query: 1489 PGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWI--NVVFIIL 1546
            P N+ +     ++ ++ FD  ++  I LN +T+ +E+       TE ++    N +F  +
Sbjct: 1120 PENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAI 1179

Query: 1547 FTGECVLKLISLRHY-----YFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVI 1601
            F GE  LK++SL  Y     Y    WN+ D  +V +SI+ + ++           + RV+
Sbjct: 1180 FVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVL 1239

Query: 1602 RLARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA----- 1656
            RL R  R LR++  A G++ ++  L+ SL  + NI L+      I+ I G+  F      
Sbjct: 1240 RLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYH 1299

Query: 1657 --------YVKKED-------GINDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKP 1701
                       + D        ++  +NF+  G +++ LF + +  GW  ++   L++  
Sbjct: 1300 CLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVA 1359

Query: 1702 PDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENF 1752
             D  P   H          NP + + YF+S+++I    V+NM++ V++ENF
Sbjct: 1360 VDQQPVTNH----------NPWM-LLYFISFLLIVSFFVLNMFVGVVVENF 1399



 Score = 94.7 bits (234), Expect = 8e-19
 Identities = 78/287 (27%), Positives = 131/287 (45%), Gaps = 41/287 (14%)

Query: 1500 LVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTGECVLKLISLR 1559
            +V ++ F+  IM+ I +N V+M +E   Q + +T +L   NVVF  +F  E +LKL +  
Sbjct: 601  IVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFG 660

Query: 1560 HY-YFTVGWNIFDFVVVIIS---IVGMFLADLIETYFVSPTLFRVIRLARIGRILRLVKG 1615
             + Y    +NIFD ++VIIS   IVG     L            V+R  R+ R+L+LV+ 
Sbjct: 661  LFDYLRNPYNIFDSIIVIISIWEIVGQADGGL-----------SVLRTFRLLRVLKLVRF 709

Query: 1616 AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA-----YVKKEDGINDMFNF 1670
               +R  L  LM ++  +    +LL L +FI++I GM  F           D + D  NF
Sbjct: 710  MPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNF 769

Query: 1671 ETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFV 1730
            ++   +++ +FQI T   W+ +L   + S  P                         YFV
Sbjct: 770  DSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWAS---------------------LYFV 808

Query: 1731 SYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWEK 1777
            + +     V+ N+ +A+++E F    + +     ED      E ++K
Sbjct: 809  ALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDK 855



 Score = 86.3 bits (212), Expect = 3e-16
 Identities = 72/298 (24%), Positives = 133/298 (44%), Gaps = 40/298 (13%)

Query: 701  PWWYRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEE 760
            P W      + ++  SP   +F+     I+     D  +   I LN + +A+E  P  E 
Sbjct: 1104 PDWCEVREDWSVYLFSPE-NRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALER-PQIEA 1161

Query: 761  FKN---VLAIGNLVFTGIFAAEMVLKLIAMDPY----EYFQVGWNIFDSLIVTLSLVELF 813
                   L + N +FT IF  EM LK++++  Y     Y +  WN+ D  +V +S++++ 
Sbjct: 1162 GSTERIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIV 1221

Query: 814  --LADVEG------LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAII 865
              LA   G      L VLR  R LR  ++    P L ++++ + +S+  +GN+ L+    
Sbjct: 1222 VSLASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAF 1281

Query: 866  VFIFAVVGMQLFGKSYKECV------CKINDDCTLP--RW--HMNDF--FHSFLIVFRVL 913
              IF ++G+QLF   +  C+           DC     RW  H  +F      L+   VL
Sbjct: 1282 FIIFGILGVQLFKGKFYHCLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVL 1341

Query: 914  CGE--WIETMWDCMEVAG---------QAMCLIVYMMVMVIGNLVVLNLFLALLLSSF 960
              +  W+  M++ ++                L+ ++  ++I +  VLN+F+ +++ +F
Sbjct: 1342 ASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENF 1399



 Score = 84.0 bits (206), Expect = 1e-15
 Identities = 66/293 (22%), Positives = 134/293 (45%), Gaps = 70/293 (23%)

Query: 128 FSMLIMCTILTNCIFMTMNN---PPDWTKNVEY---TFTGIYTFESLVKILARGFCVGEF 181
           F+  IM  IL N + M + +   P + T  +E     FT ++  E ++K+ A G     F
Sbjct: 607 FNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGL----F 662

Query: 182 TFLRDPWNWLDFVVIVFAYLTEFVNL--GNVSALRTFRVLRALKTISVIPGLKTIVGALI 239
            +LR+P+N  D ++++ + + E V    G +S LRTFR+LR LK +  +P L+  +  L+
Sbjct: 663 DYLRNPYNIFDSIIVIIS-IWEIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLM 721

Query: 240 QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETLESIMNTLESEEDF 299
           +++  ++   +L +  + +F+++G+                                   
Sbjct: 722 KTMDNVATFCMLLMLFIFIFSILGM----------------------------------- 746

Query: 300 RKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLALFRLMT 359
                ++ G K +L     TD+G              PD    +FD+  WA + +F+++T
Sbjct: 747 -----HIFGCKFSL----RTDTGDTV-----------PDR--KNFDSLLWAIVTVFQILT 784

Query: 360 QDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQAN 412
           Q+ W  +    + +      ++FV ++  G++ L NL++A++   ++ +  AN
Sbjct: 785 QEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILVEGFQAEGDAN 837



 Score = 67.4 bits (163), Expect = 1e-10
 Identities = 51/186 (27%), Positives = 96/186 (51%), Gaps = 19/186 (10%)

Query: 729 IVMDPFVDLAITICIVLNTLFMAMEHHP------MTEEFKNVLAIGNLVFTGIFAAEMVL 782
           +V +P+ +    + I+LN + + M + P      +++  K +    + +F   FA EMVL
Sbjct: 75  MVCNPWFECVSMLVILLNCVTLGM-YQPCDDMDCLSDRCKILQVFDDFIFI-FFAMEMVL 132

Query: 783 KLIAMDPYE---YFQVGWNIFDSLIVTLSLVELFLADVEG--LSVLRSFRLLRVFKLAKS 837
           K++A+  +    Y    WN  D  IV   +VE  L D++   LS +R+ R+LR  K    
Sbjct: 133 KMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSL-DLQNINLSAIRTVRVLRPLKAINR 191

Query: 838 WPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-----GKSYKECVCKINDDC 892
            P++ +L+ ++ +++  LGN+ L+   + FIF ++G+QL+      + + E    I  D 
Sbjct: 192 VPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDV 251

Query: 893 TLPRWH 898
            LP ++
Sbjct: 252 ALPPYY 257



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 73/338 (21%), Positives = 134/338 (39%), Gaps = 95/338 (28%)

Query: 121  KILVHSL--------FSMLIMCTILTNCIFMTMNNPPDWT---KNVEYTFTGIYTFESLV 169
            ++L+HS+        F   I+C  +        N P       K   Y FT ++  E+++
Sbjct: 1442 RLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVL 1501

Query: 170  KILARGFCVGEFTFLRDPWNWLDFVVIVFAY----LTEF-------VNLGNVSALRTFRV 218
            K++A G       F +D WN LD  +++ +     L E        +N   +  +R  R+
Sbjct: 1502 KLVAFGLR----RFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRI 1557

Query: 219  LRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRN 278
             R LK + +  G++ ++  ++Q++ ++ ++ +L  F L  F    L +            
Sbjct: 1558 ARVLKLLKMATGMRALLDTVVQALPQVGNLGLL--FMLLFFIYAALGV------------ 1603

Query: 279  SLENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPD 338
                              E F K           L+C    D   C EG +         
Sbjct: 1604 ------------------ELFGK-----------LVCN---DENPC-EGMS--------- 1621

Query: 339  YGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLR-----------AAGKTYMIFFVVVIF 387
              + +F+ F  AFL LF++ T D W  + + TLR           +      ++FV  + 
Sbjct: 1622 -RHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVL 1680

Query: 388  LGSFYLINLILAVVAMAYEEQNQANIEEAK-QKELEFQ 424
               F LIN+++AV+    ++ N+   E+A+   ELE +
Sbjct: 1681 TAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAELELE 1718



 Score = 55.5 bits (132), Expect = 5e-07
 Identities = 46/165 (27%), Positives = 75/165 (45%), Gaps = 15/165 (9%)

Query: 1500 LVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMT----EVLYWINVVFIILFTGECVLKL 1555
            +V N  F+   M++I LN VT+ + +            ++L   +    I F  E VLK+
Sbjct: 75   MVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKM 134

Query: 1556 ISL----RHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRLARIGRILR 1611
            ++L    +  Y    WN  DF +V+  +V   L        +       IR  R+ R L+
Sbjct: 135  VALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLD-------LQNINLSAIRTVRVLRPLK 187

Query: 1612 LVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA 1656
             +     +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 188  AINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWA 232



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 15/59 (25%), Positives = 39/59 (66%), Gaps = 2/59 (3%)

Query: 904 HSFLIVFRVLCGE-WIETMWDCMEVAGQAMCLIVYMMVMVIGNLVVLNLFLALLLSSFS 961
           ++++++F+V+  E W+E M+  M+ A      I +++++++G+  ++NL L ++ + FS
Sbjct: 345 YAWIVIFQVITLEGWVEIMYYVMD-AHSFYNFIYFILLIIVGSFFMINLCLVVIATQFS 402



 Score = 31.6 bits (70), Expect = 8.0
 Identities = 18/85 (21%), Positives = 35/85 (41%), Gaps = 21/85 (24%)

Query: 1669 NFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFY 1728
            NF+  G + I +FQ+ T  GW  ++  ++++                     +      Y
Sbjct: 339  NFDNIGYAWIVIFQVITLEGWVEIMYYVMDA---------------------HSFYNFIY 377

Query: 1729 FVSYIIISFLVVVNMYIAVILENFS 1753
            F+  II+    ++N+ + VI   FS
Sbjct: 378  FILLIIVGSFFMINLCLVVIATQFS 402


>gi|21361077 calcium channel, voltage-dependent, T type, alpha 1I
            subunit isoform a [Homo sapiens]
          Length = 2223

 Score =  342 bits (877), Expect = 2e-93
 Identities = 209/625 (33%), Positives = 345/625 (55%), Gaps = 39/625 (6%)

Query: 1171 RKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILEM 1230
            R  C  I+ H  F+  ++  I L+   +A E   IE   T +I L  ++ IFT IF+ EM
Sbjct: 1160 RVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEM 1219

Query: 1231 LLKWIA----YGYKTYFTNAWCWLDFLIVDVSLVTLV---ANTLGYSDLGPIKSLRTLRA 1283
             LK ++    +G + Y  ++W  LD  +V VS++ +V   A+  G   LG ++ LR LR 
Sbjct: 1220 TLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRT 1279

Query: 1284 LRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTT 1343
            LRPLR +SR  G+++VV  LI ++  I N++L+C  F++IF I+GV LF GKFY C+   
Sbjct: 1280 LRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVD 1339

Query: 1344 DGSRFPASQVPNRSECFALMNVSQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYA 1403
                     + NRS+C A      N RW + K NFDN+G   +SL  +A+  GW  IMY 
Sbjct: 1340 ------TRNITNRSDCMAA-----NYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYN 1388

Query: 1404 AVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFM 1463
             +D+V VD+QP   ++ +M +YF+ F++  SFF LN+F+GV+++NF++ ++    ++   
Sbjct: 1389 GLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARR 1448

Query: 1464 TEEQKKYYNAMKKLGSKKPQKPIPRPGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMV 1523
             EE  K    ++K   K  + P        +  I  + T+   DI I  +ICLN+VTM +
Sbjct: 1449 REE--KRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSL 1506

Query: 1524 EKEGQSQHMTEVLYWINVVFIILFTGECVLKLISL-RHYYFTVGWNIFDFVVVIISIVGM 1582
            E   Q   +   L + N +F  +F  E VLKL++     +F   WN  D  +V++S++G+
Sbjct: 1507 EHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGI 1566

Query: 1583 FL--ADLIETYFVSPTLFRVIRLARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLL 1640
             L   ++     ++PT+ R++R+ RI R+L+L+K A G+R LL  ++ +LP + N+GLL 
Sbjct: 1567 TLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLF 1626

Query: 1641 FLVMFIYAIFGMSNFAYVKKED-----GINDMFNFETFGNSMICLFQITTSAGWDGLLAP 1695
             L+ FIYA  G+  F  +   D     G++    FE FG + + LFQ++T   W+G++  
Sbjct: 1627 MLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKD 1686

Query: 1696 ILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENFSVA 1755
             L     DC   +    SS++       V   YFVS+++ +  V++N+ +AV++++   +
Sbjct: 1687 TLR----DCTHDERSCLSSLQ------FVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDS 1736

Query: 1756 TEESTEPLSEDDFEMFYEVWEKFDP 1780
             +E+ E  +E D E+  E+     P
Sbjct: 1737 NKEAQED-AEMDAELELEMAHGLGP 1760



 Score =  151 bits (381), Expect = 7e-36
 Identities = 86/272 (31%), Positives = 155/272 (56%), Gaps = 9/272 (3%)

Query: 712 IWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAIGNLV 771
           +W C   W + +  +  IV   + +  I + I++NT+ M +EHH   EE  N+L I N+V
Sbjct: 619 VWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVV 678

Query: 772 FTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADVEGLSVLRSFRLLRV 831
           FT +FA EM+LKL A   ++Y +  +NIFDS+IV +S+ E+      GLSVLR+FRLLRV
Sbjct: 679 FTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQADGGLSVLRTFRLLRV 738

Query: 832 FKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDD 891
            KL +  P L   + ++  ++  +    ++L + +FIF+++GM +FG  +     + +  
Sbjct: 739 LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFS---LRTDTG 795

Query: 892 CTLP-RWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQAMCLIVYMMVMVIGNLVVL 949
            T+P R + +    + + VF++L  E W   +++ M  +      + ++ +M  GN V+ 
Sbjct: 796 DTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGM-ASTSPWASLYFVALMTFGNYVLF 854

Query: 950 NLFLALLLSSFSSD---NLTAIEEDPDANNLQ 978
           NL +A+L+  F ++   N +  +ED  ++N++
Sbjct: 855 NLLVAILVEGFQAEGDANRSYSDEDQSSSNIE 886



 Score =  132 bits (333), Expect = 3e-30
 Identities = 107/391 (27%), Positives = 182/391 (46%), Gaps = 66/391 (16%)

Query: 67  PPGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRISIKILVHS 126
           PPG+  EPL+  DP+                    A  A + L   +  R   IK++ + 
Sbjct: 35  PPGL-EEPLDGADPHVPHPDL--------------APIAFFCLRQTTSPRNWCIKMVCNP 79

Query: 127 LFSMLIMCTILTNCIFMTMNNP-------PDWTKNVEYTFTGIYTF---ESLVKILARGF 176
            F  + M  IL NC+ + M  P        D  K ++     I+ F   E ++K++A G 
Sbjct: 80  WFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGI 139

Query: 177 CVGEFTFLRDPWNWLDFVVIVFAYLTEFVNLGNV--SALRTFRVLRALKTISVIPGLKTI 234
             G+  +L D WN LDF +++   +   ++L N+  SA+RT RVLR LK I+ +P ++ +
Sbjct: 140 -FGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRIL 198

Query: 235 VGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETLE---SIMN 291
           V  L+ ++  L +V++L  F   +F +IG+QL+ G L+++CF   LE N T++   ++  
Sbjct: 199 VNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCF---LEENFTIQGDVALPP 255

Query: 292 TLESEEDFRKYFYYLEGSKDALL--------------CGFSTD--------------SGQ 323
             + EED    F       + ++              C  S D              SG 
Sbjct: 256 YYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDVYDFGAGRQDLNASGL 315

Query: 324 CPEG---YTCVKIG-RNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYM 379
           C      Y   + G  NP  G  +FD   +A++ +F+++T + W  +    + A      
Sbjct: 316 CVNWNRYYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNF 375

Query: 380 IFFVVVIFLGSFYLINLILAVVAMAYEEQNQ 410
           I+F+++I +GSF++INL L V+A  + E  Q
Sbjct: 376 IYFILLIIVGSFFMINLCLVVIATQFSETKQ 406



 Score =  126 bits (317), Expect = 2e-28
 Identities = 111/413 (26%), Positives = 186/413 (45%), Gaps = 102/413 (24%)

Query: 1133 EPMNSDEPEACFTDGCVRRFSCCQVNIESGKGKIWWNIRKTCYKIVEHSWFESFIVLMIL 1192
            EP++  +P     D     F C +              R  C K+V + WFE   +L+IL
Sbjct: 40   EPLDGADPHVPHPDLAPIAFFCLRQTTSP---------RNWCIKMVCNPWFECVSMLVIL 90

Query: 1193 LSSGALAFE------DIYIERKKTIKIILEYADKIFTYIFILEMLLKWIA---YGYKTYF 1243
            L+   L         D   +R K +++   + D IF + F +EM+LK +A   +G K Y 
Sbjct: 91   LNCVTLGMYQPCDDMDCLSDRCKILQV---FDDFIFIF-FAMEMVLKMVALGIFGKKCYL 146

Query: 1244 TNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNAL 1303
             + W  LDF IV   +  +V  +L   ++  + ++RT+R LRPL+A++R   MR++VN L
Sbjct: 147  GDTWNRLDFFIV---MAGMVEYSLDLQNIN-LSAIRTVRVLRPLKAINRVPSMRILVNLL 202

Query: 1304 IGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG---------------------KFYE---- 1338
            +  +P + NVLL+C   + IF I+GV L+AG                      +Y+    
Sbjct: 203  LDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEED 262

Query: 1339 ------CINTTDGSRFPASQVP-----NRSECFALMNV------SQNVRWKNLKVNFDNV 1381
                  C  + D       ++P      R  C +  +V       Q++    L VN++  
Sbjct: 263  DEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDVYDFGAGRQDLNASGLCVNWNRY 322

Query: 1382 -------------------GLGY--LSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSL 1420
                                +GY  + + QV T +GW  IMY  +D+          +S 
Sbjct: 323  YNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDA----------HSF 372

Query: 1421 YMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNA 1473
            Y +IYF++ II GSFF +NL + VI   F++ K++   +   M E++++Y ++
Sbjct: 373  YNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---EHRLMLEQRQRYLSS 422



 Score =  114 bits (284), Expect = 1e-24
 Identities = 87/364 (23%), Positives = 159/364 (43%), Gaps = 73/364 (20%)

Query: 105  ALYMLSPFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVE-------- 156
            ++Y+ SP +  R +   I+ H LF  +++  I  NCI + +  P     + E        
Sbjct: 1149 SVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSN 1208

Query: 157  YTFTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVNL--------- 207
            Y FT I+  E  +K+++ G   GE  +LR  WN LD  ++  + +   V+L         
Sbjct: 1209 YIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKIL 1268

Query: 208  GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 267
            G +  LR  R LR L+ IS  PGLK +V  LI S+K + +++++      +F ++G+QLF
Sbjct: 1269 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLF 1328

Query: 268  MGNLKHKCFRNSLENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEG 327
             G                                 FY+  G           D+      
Sbjct: 1329 KGK--------------------------------FYHCLG----------VDTRNITNR 1346

Query: 328  YTCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQDYWENLY----------QQTLRAAGKT 377
              C+       +   +FD    A ++LF L ++D W N+           QQ +      
Sbjct: 1347 SDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPW 1406

Query: 378  YMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQ-ANIEEAKQKELEFQQMLDRLKKEQEE 436
             +++F+  + + SF+++N+ + VV   + +  Q    EEA+++E   ++ L RL+K++ +
Sbjct: 1407 MLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRRE---EKRLRRLEKKRRK 1463

Query: 437  AEAI 440
            A+ +
Sbjct: 1464 AQRL 1467



 Score =  107 bits (268), Expect = 9e-23
 Identities = 124/578 (21%), Positives = 245/578 (42%), Gaps = 83/578 (14%)

Query: 904  HSFLIVFRVLCGE-WIETMWDCMEVAGQAMCLIVYMMVMVIGNLVVLNLFLALLLSSFSS 962
            ++++++F+V+  E W+E M+  M+ A      I +++++++G+  ++NL L ++ + FS 
Sbjct: 345  YAWIVIFQVITLEGWVEIMYYVMD-AHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSE 403

Query: 963  ----DNLTAIEEDPDANNLQIAVTRIKKG------INYVKQTLREFILKAFSKKPKISRE 1012
                ++   +E+     +     +  + G        YV   LR+   +A      +   
Sbjct: 404  TKQREHRLMLEQRQRYLSSSTVASYAEPGDCYEEIFQYVCHILRKAKRRALGLYQALQSR 463

Query: 1013 IRQA----------EDLNTKKENYISNHTLAEMSKG-HNFLKEKDKISGFGSSVDKHLME 1061
             RQA             + K+  +    T  +  +G H   +    + G  S  + H   
Sbjct: 464  -RQALGPEAPAPAKPGPHAKEPRHYHGKTKGQGDEGRHLGSRHCQTLHGPASPGNDHSGR 522

Query: 1062 DSDGQSFIHNP-SLTVTVPIAPGESDLENMNAEELSSDSDSEYSKVRLNRSSSSECSTVD 1120
            +   Q   H+P   T    + P  + L +  A       +       L  + S +  +  
Sbjct: 523  ELCPQ---HSPLDATPHTLVQPIPATLASDPASCPCCQHEDGRRPSGLGSTDSGQEGSGS 579

Query: 1121 NPLPGEGEEAEAEPMNSDEPEACFTDGCVRRFSCCQVNIESGKGKIW-----W-NIRKTC 1174
                G  +EA+ +   S E      DG        +   E   G +W     W   R   
Sbjct: 580  GSSAGGEDEADGDGARSSE------DGASSELGKEEEEEEQADGAVWLCGDVWRETRAKL 633

Query: 1175 YKIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILEMLLKW 1234
              IV+  +F   I++ IL+++ ++  E  + E+ + +  ILE  + +FT +F LEM+LK 
Sbjct: 634  RGIVDSKYFNRGIMMAILVNTVSMGIE--HHEQPEELTNILEICNVVFTSMFALEMILKL 691

Query: 1235 IAYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSRFE 1294
             A+G   Y  N +   D +IV +S+  +V    G +D G +  LRT R LR L+ +    
Sbjct: 692  AAFGLFDYLRNPYNIFDSIIVIISIWEIV----GQAD-GGLSVLRTFRLLRVLKLVRFMP 746

Query: 1295 GMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDGSRFPASQVP 1354
             +R  +  L+  + ++    ++ ++F  IFSI+G+++F  KF    +T D        VP
Sbjct: 747  ALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGD-------TVP 799

Query: 1355 NRSECFALMNVSQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQP 1414
            +R                    NFD++    +++ Q+ T + W +++Y  + S       
Sbjct: 800  DRK-------------------NFDSLLWAIVTVFQILTQEDWNVVLYNGMAST------ 834

Query: 1415 KYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQ 1452
                S +  +YFV  + FG++   NL + ++++ F  +
Sbjct: 835  ----SPWASLYFVALMTFGNYVLFNLLVAILVEGFQAE 868



 Score =  107 bits (266), Expect = 2e-22
 Identities = 82/309 (26%), Positives = 147/309 (47%), Gaps = 34/309 (11%)

Query: 690  EELEESRQKCPPWWYRFAHKFLIWNCSPYWIKF---KKCIYFIVMDPFVDLAITICIVLN 746
            +E EE+R++      R   K       PY+  +   +  I+ +    ++D+ IT  I LN
Sbjct: 1441 QEAEEARRREEKRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLN 1500

Query: 747  TLFMAMEHHPMTEEFKNVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVT 806
             + M++EH+      +  L   N +FT +F  E VLKL+A     +F+  WN  D  IV 
Sbjct: 1501 VVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVL 1560

Query: 807  LSLVELFLADVE----------GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALG 856
            LS++ + L ++E           + ++R  R+ RV KL K    +  L+  +  ++  +G
Sbjct: 1561 LSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVG 1620

Query: 857  NLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWH--MNDFFHSFLIVFRVLC 914
            NL L+  ++ FI+A +G++LFGK     VC   + C     H    +F  +FL +F+V  
Sbjct: 1621 NLGLLFMLLFFIYAALGVELFGK----LVCNDENPCEGMSRHATFENFGMAFLTLFQVST 1676

Query: 915  GE-W----IETMWDCMEVAGQAMCL--------IVYMMVMVIGNLVVLNLFLALLLSSFS 961
            G+ W     +T+ DC     +  CL        + ++  ++    V++N+ +A+L+    
Sbjct: 1677 GDNWNGIMKDTLRDCTH--DERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLD 1734

Query: 962  SDNLTAIEE 970
              N  A E+
Sbjct: 1735 DSNKEAQED 1743



 Score =  102 bits (254), Expect = 4e-21
 Identities = 73/291 (25%), Positives = 136/291 (46%), Gaps = 38/291 (13%)

Query: 1489 PGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWI--NVVFIIL 1546
            P N+ +     ++ ++ FD  ++  I LN +T+ +E+       TE ++    N +F  +
Sbjct: 1155 PENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAI 1214

Query: 1547 FTGECVLKLISLRHY-----YFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVI 1601
            F GE  LK++SL  Y     Y    WN+ D  +V +SI+ + ++           + RV+
Sbjct: 1215 FVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVL 1274

Query: 1602 RLARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA----- 1656
            RL R  R LR++  A G++ ++  L+ SL  + NI L+      I+ I G+  F      
Sbjct: 1275 RLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYH 1334

Query: 1657 --------YVKKED-------GINDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKP 1701
                       + D        ++  +NF+  G +++ LF + +  GW  ++   L++  
Sbjct: 1335 CLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVA 1394

Query: 1702 PDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENF 1752
             D  P   H          NP + + YF+S+++I    V+NM++ V++ENF
Sbjct: 1395 VDQQPVTNH----------NPWM-LLYFISFLLIVSFFVLNMFVGVVVENF 1434



 Score = 94.7 bits (234), Expect = 8e-19
 Identities = 78/287 (27%), Positives = 131/287 (45%), Gaps = 41/287 (14%)

Query: 1500 LVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTGECVLKLISLR 1559
            +V ++ F+  IM+ I +N V+M +E   Q + +T +L   NVVF  +F  E +LKL +  
Sbjct: 636  IVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFG 695

Query: 1560 HY-YFTVGWNIFDFVVVIIS---IVGMFLADLIETYFVSPTLFRVIRLARIGRILRLVKG 1615
             + Y    +NIFD ++VIIS   IVG     L            V+R  R+ R+L+LV+ 
Sbjct: 696  LFDYLRNPYNIFDSIIVIISIWEIVGQADGGL-----------SVLRTFRLLRVLKLVRF 744

Query: 1616 AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA-----YVKKEDGINDMFNF 1670
               +R  L  LM ++  +    +LL L +FI++I GM  F           D + D  NF
Sbjct: 745  MPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNF 804

Query: 1671 ETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFV 1730
            ++   +++ +FQI T   W+ +L   + S  P                         YFV
Sbjct: 805  DSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWAS---------------------LYFV 843

Query: 1731 SYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWEK 1777
            + +     V+ N+ +A+++E F    + +     ED      E ++K
Sbjct: 844  ALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDK 890



 Score = 86.3 bits (212), Expect = 3e-16
 Identities = 72/298 (24%), Positives = 133/298 (44%), Gaps = 40/298 (13%)

Query: 701  PWWYRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEE 760
            P W      + ++  SP   +F+     I+     D  +   I LN + +A+E  P  E 
Sbjct: 1139 PDWCEVREDWSVYLFSPE-NRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALER-PQIEA 1196

Query: 761  FKN---VLAIGNLVFTGIFAAEMVLKLIAMDPY----EYFQVGWNIFDSLIVTLSLVELF 813
                   L + N +FT IF  EM LK++++  Y     Y +  WN+ D  +V +S++++ 
Sbjct: 1197 GSTERIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIV 1256

Query: 814  --LADVEG------LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAII 865
              LA   G      L VLR  R LR  ++    P L ++++ + +S+  +GN+ L+    
Sbjct: 1257 VSLASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAF 1316

Query: 866  VFIFAVVGMQLFGKSYKECV------CKINDDCTLP--RW--HMNDF--FHSFLIVFRVL 913
              IF ++G+QLF   +  C+           DC     RW  H  +F      L+   VL
Sbjct: 1317 FIIFGILGVQLFKGKFYHCLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVL 1376

Query: 914  CGE--WIETMWDCMEVAG---------QAMCLIVYMMVMVIGNLVVLNLFLALLLSSF 960
              +  W+  M++ ++                L+ ++  ++I +  VLN+F+ +++ +F
Sbjct: 1377 ASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENF 1434



 Score = 84.0 bits (206), Expect = 1e-15
 Identities = 66/293 (22%), Positives = 134/293 (45%), Gaps = 70/293 (23%)

Query: 128 FSMLIMCTILTNCIFMTMNN---PPDWTKNVEY---TFTGIYTFESLVKILARGFCVGEF 181
           F+  IM  IL N + M + +   P + T  +E     FT ++  E ++K+ A G     F
Sbjct: 642 FNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGL----F 697

Query: 182 TFLRDPWNWLDFVVIVFAYLTEFVNL--GNVSALRTFRVLRALKTISVIPGLKTIVGALI 239
            +LR+P+N  D ++++ + + E V    G +S LRTFR+LR LK +  +P L+  +  L+
Sbjct: 698 DYLRNPYNIFDSIIVIIS-IWEIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLM 756

Query: 240 QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETLESIMNTLESEEDF 299
           +++  ++   +L +  + +F+++G+                                   
Sbjct: 757 KTMDNVATFCMLLMLFIFIFSILGM----------------------------------- 781

Query: 300 RKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLALFRLMT 359
                ++ G K +L     TD+G              PD    +FD+  WA + +F+++T
Sbjct: 782 -----HIFGCKFSL----RTDTGDTV-----------PDR--KNFDSLLWAIVTVFQILT 819

Query: 360 QDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQAN 412
           Q+ W  +    + +      ++FV ++  G++ L NL++A++   ++ +  AN
Sbjct: 820 QEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILVEGFQAEGDAN 872



 Score = 67.4 bits (163), Expect = 1e-10
 Identities = 51/186 (27%), Positives = 96/186 (51%), Gaps = 19/186 (10%)

Query: 729 IVMDPFVDLAITICIVLNTLFMAMEHHP------MTEEFKNVLAIGNLVFTGIFAAEMVL 782
           +V +P+ +    + I+LN + + M + P      +++  K +    + +F   FA EMVL
Sbjct: 75  MVCNPWFECVSMLVILLNCVTLGM-YQPCDDMDCLSDRCKILQVFDDFIFI-FFAMEMVL 132

Query: 783 KLIAMDPYE---YFQVGWNIFDSLIVTLSLVELFLADVEG--LSVLRSFRLLRVFKLAKS 837
           K++A+  +    Y    WN  D  IV   +VE  L D++   LS +R+ R+LR  K    
Sbjct: 133 KMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSL-DLQNINLSAIRTVRVLRPLKAINR 191

Query: 838 WPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-----GKSYKECVCKINDDC 892
            P++ +L+ ++ +++  LGN+ L+   + FIF ++G+QL+      + + E    I  D 
Sbjct: 192 VPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDV 251

Query: 893 TLPRWH 898
            LP ++
Sbjct: 252 ALPPYY 257



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 73/338 (21%), Positives = 134/338 (39%), Gaps = 95/338 (28%)

Query: 121  KILVHSL--------FSMLIMCTILTNCIFMTMNNPPDWT---KNVEYTFTGIYTFESLV 169
            ++L+HS+        F   I+C  +        N P       K   Y FT ++  E+++
Sbjct: 1477 RLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVL 1536

Query: 170  KILARGFCVGEFTFLRDPWNWLDFVVIVFAY----LTEF-------VNLGNVSALRTFRV 218
            K++A G       F +D WN LD  +++ +     L E        +N   +  +R  R+
Sbjct: 1537 KLVAFGLR----RFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRI 1592

Query: 219  LRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRN 278
             R LK + +  G++ ++  ++Q++ ++ ++ +L  F L  F    L +            
Sbjct: 1593 ARVLKLLKMATGMRALLDTVVQALPQVGNLGLL--FMLLFFIYAALGV------------ 1638

Query: 279  SLENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPD 338
                              E F K           L+C    D   C EG +         
Sbjct: 1639 ------------------ELFGK-----------LVCN---DENPC-EGMS--------- 1656

Query: 339  YGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLR-----------AAGKTYMIFFVVVIF 387
              + +F+ F  AFL LF++ T D W  + + TLR           +      ++FV  + 
Sbjct: 1657 -RHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVL 1715

Query: 388  LGSFYLINLILAVVAMAYEEQNQANIEEAK-QKELEFQ 424
               F LIN+++AV+    ++ N+   E+A+   ELE +
Sbjct: 1716 TAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAELELE 1753



 Score = 55.5 bits (132), Expect = 5e-07
 Identities = 46/165 (27%), Positives = 75/165 (45%), Gaps = 15/165 (9%)

Query: 1500 LVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMT----EVLYWINVVFIILFTGECVLKL 1555
            +V N  F+   M++I LN VT+ + +            ++L   +    I F  E VLK+
Sbjct: 75   MVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKM 134

Query: 1556 ISL----RHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRLARIGRILR 1611
            ++L    +  Y    WN  DF +V+  +V   L        +       IR  R+ R L+
Sbjct: 135  VALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLD-------LQNINLSAIRTVRVLRPLK 187

Query: 1612 LVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA 1656
             +     +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 188  AINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWA 232



 Score = 31.6 bits (70), Expect = 8.0
 Identities = 18/85 (21%), Positives = 35/85 (41%), Gaps = 21/85 (24%)

Query: 1669 NFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFY 1728
            NF+  G + I +FQ+ T  GW  ++  ++++                     +      Y
Sbjct: 339  NFDNIGYAWIVIFQVITLEGWVEIMYYVMDA---------------------HSFYNFIY 377

Query: 1729 FVSYIIISFLVVVNMYIAVILENFS 1753
            F+  II+    ++N+ + VI   FS
Sbjct: 378  FILLIIVGSFFMINLCLVVIATQFS 402


>gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H
            subunit isoform b [Homo sapiens]
          Length = 2347

 Score =  342 bits (876), Expect = 3e-93
 Identities = 207/654 (31%), Positives = 367/654 (56%), Gaps = 44/654 (6%)

Query: 1171 RKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILEM 1230
            R +C K++ H  F+  +++ I L+   +A E   I+   T ++ L  ++ IFT IF+ EM
Sbjct: 1284 RVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEM 1343

Query: 1231 LLKWIAYGYKT----YFTNAWCWLDFLIVDVSLVTLV---ANTLGYSDLGPIKSLRTLRA 1283
            ++K +A G  +    Y  ++W  LD L+V VSLV +V   A+  G   LG ++ LR LR 
Sbjct: 1344 MVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRT 1403

Query: 1284 LRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTT 1343
            LRPLR +SR  G+++VV  LI ++  I N++L+C  F++IF I+GV LF GKFY C    
Sbjct: 1404 LRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPD 1463

Query: 1344 DGSRFPASQVPNRSECFALMNVSQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYA 1403
                     +  +++C A      + RW   K NFDN+G   +SL  +++  GW  IMY 
Sbjct: 1464 ------TRNISTKAQCRAA-----HYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYD 1512

Query: 1404 AVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFM 1463
             +D+V VD+QP   ++ +M +YF+ F++  SFF LN+F+GV+++NF++ ++    ++   
Sbjct: 1513 GLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARR 1572

Query: 1464 TEEQKKYYNAMKKLGSKKPQKPIPRPGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMV 1523
             EE  K    +++   K  ++P     +  +  I  L T+   D+ I  +IC+N++TM +
Sbjct: 1573 REE--KRLRRLERRRRKAQRRPYYADYSPTRRSIHSLCTSHYLDLFITFIICVNVITMSM 1630

Query: 1524 EKEGQSQHMTEVLYWINVVFIILFTGECVLKLISLR-HYYFTVGWNIFDFVVVIISIVGM 1582
            E   Q + + E L + N VF I+F  E  LKL++     +F   WN  D  +V++S++G+
Sbjct: 1631 EHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGI 1690

Query: 1583 FL--ADLIETYFVSPTLFRVIRLARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLL 1640
             L   ++     ++PT+ R++R+ RI R+L+L+K A G+R LL  ++ +LP + N+GLL 
Sbjct: 1691 TLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLF 1750

Query: 1641 FLVMFIYAIFGMSNFAYVK-KED----GINDMFNFETFGNSMICLFQITTSAGWDGLLAP 1695
             L+ FIYA  G+  F  ++  ED    G++    F  FG + + LF+++T   W+G++  
Sbjct: 1751 MLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKD 1810

Query: 1696 ILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENFSVA 1755
             L     +C  +  H  S +      P++   YFV++++++  V+VN+ +AV++++   +
Sbjct: 1811 TLR----ECSREDKHCLSYL------PALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEES 1860

Query: 1756 TEESTEPLSEDDFEMFYEVWEKFDPDATQFIEFSK---LSDFAAALDPPLLIAK 1806
             +E+ E  +E D E+  E+ +   P + + ++  +     +   A D P L+A+
Sbjct: 1861 NKEARED-AELDAEIELEMAQ--GPGSARRVDADRPPLPQESPGARDAPNLVAR 1911



 Score =  158 bits (399), Expect = 6e-38
 Identities = 195/892 (21%), Positives = 370/892 (41%), Gaps = 173/892 (19%)

Query: 121  KILVHSLFSMLIMCTILTNCIFMTMN---NPPDWTKNVEYT---FTGIYTFESLVKILAR 174
            +I+    FS  IM  IL N + M +     P + T  +E +   FT ++  E L+K+LA 
Sbjct: 788  RIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLA- 846

Query: 175  GFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVNL--GNVSALRTFRVLRALKTISVIPGLK 232
                G   ++R+P+N  D +++V + + E V    G +S LRTFR+LR LK +  +P L+
Sbjct: 847  ---CGPLGYIRNPYNIFDGIIVVIS-VWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALR 902

Query: 233  TIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETLESIMNT 292
              +  L++++  ++    L +  + +F+++G+ LF                         
Sbjct: 903  RQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLF------------------------- 937

Query: 293  LESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFL 352
                           G K +L     TD+G              PD    +FD+  WA +
Sbjct: 938  ---------------GCKFSL----KTDTGDTV-----------PDR--KNFDSLLWAIV 965

Query: 353  ALFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQAN 412
             +F+++TQ+ W  +    + +      ++FV ++  G++ L NL++A++   ++ +  AN
Sbjct: 966  TVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDAN 1025

Query: 413  IEEAKQKE--LEFQQMLDRLKKEQEEAEAIAAAAAEYTSIRRSRIMGLSESSSETSKLSS 470
              +  + +  + F++   +L++ Q     + + A          + G    S      ++
Sbjct: 1026 RSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAVT----PNGHLEGRGSLSPPLIMCTA 1081

Query: 471  KSAKERRNRRKKKNQKKLSSGEEKGDAEKLSKSESEDSIRRKSFHLGVEGHRRAHEKRLS 530
             +          K+   L +     D+ + S S  +  +          G ++      S
Sbjct: 1082 ATPMPT-----PKSSPFLDAAPSLPDSRRGSSSSGDPPL----------GDQKPPASLRS 1126

Query: 531  TPNQSPLSIRGSLFSARRSSRTSLF---SFKGRGRDIGSETEFADDEHSIFGDNESRRGS 587
            +P  +P    G+ +S+RRSS +SL    S K RG+  G        E     D+E+  G 
Sbjct: 1127 SPC-APWGPSGA-WSSRRSSWSSLGRAPSLKRRGQ-CGERESLLSGEGKGSTDDEAEDGR 1183

Query: 588  LFV-PHRPQERRSSNISQASRSPPMLPVNGKMHSAVDCNGVVSLVDGRSALMLPNGQLLP 646
                P     RR+ ++      P  LP         D +G V        + LP+   L 
Sbjct: 1184 AAPGPRATPLRRAESLDPRPLRPAALPPT----KCRDRDGQV--------VALPSDFFL- 1230

Query: 647  EGTTNQIHKKRRCSSYLLSEDMLNDPNLRQRAMSRASILTNTVEELEESRQKCPPWWYRF 706
                       R  S+      L+D +     +    +L           +   P W R 
Sbjct: 1231 -----------RIDSHREDAAELDDDSEDSCCLRLHKVL-----------EPYKPQWCRS 1268

Query: 707  AHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEH---HPMTEEFKN 763
               + ++  SP   +F+     ++     D  + + I LN + +A+E     P + E + 
Sbjct: 1269 REAWALYLFSPQ-NRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTE-RV 1326

Query: 764  VLAIGNLVFTGIFAAEMVLKLIAMD----PYEYFQVGWNIFDSLIVTLSLVELFLADVEG 819
             L++ N +FT IF AEM++K++A+      + Y Q  WN+ D L+V +SLV++ +A    
Sbjct: 1327 FLSVSNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASA 1386

Query: 820  --------LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAV 871
                    L VLR  R LR  ++    P L ++++ + +S+  +GN+ L+      IF +
Sbjct: 1387 GGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGI 1446

Query: 872  VGMQLF-GKSY-----------KECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGE--W 917
            +G+QLF GK Y            +  C+      + R +  D     L+   VL  +  W
Sbjct: 1447 LGVQLFKGKFYYCEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGW 1506

Query: 918  IETMWDCMEVAG---------QAMCLIVYMMVMVIGNLVVLNLFLALLLSSF 960
            +  M+D ++  G             L+ ++  ++I +  VLN+F+ +++ +F
Sbjct: 1507 VNIMYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENF 1558



 Score =  143 bits (361), Expect = 1e-33
 Identities = 86/258 (33%), Positives = 144/258 (55%), Gaps = 9/258 (3%)

Query: 719  WIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAIGNLVFTGIFAA 778
            W+ F   +  IV   +    I + I++NTL M +E+H   EE  N L I N+VFT +FA 
Sbjct: 779  WVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFAL 838

Query: 779  EMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADVEGLSVLRSFRLLRVFKLAKSW 838
            EM+LKL+A  P  Y +  +NIFD +IV +S+ E+      GLSVLR+FRLLRV KL +  
Sbjct: 839  EMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFL 898

Query: 839  PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLP-RW 897
            P L   + ++  ++  +     +L + +FIF+++GM LFG  +     K +   T+P R 
Sbjct: 899  PALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFS---LKTDTGDTVPDRK 955

Query: 898  HMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQAMCLIVYMMVMVIGNLVVLNLFLALL 956
            + +    + + VF++L  E W   +++ M  +  +   + ++ +M  GN V+ NL +A+L
Sbjct: 956  NFDSLLWAIVTVFQILTQEDWNVVLYNGM-ASTSSWAALYFVALMTFGNYVLFNLLVAIL 1014

Query: 957  LSSFSSD---NLTAIEED 971
            +  F ++   N +  +ED
Sbjct: 1015 VEGFQAEGDANRSDTDED 1032



 Score =  137 bits (344), Expect = 1e-31
 Identities = 107/382 (28%), Positives = 170/382 (44%), Gaps = 95/382 (24%)

Query: 1171 RKTCYKIVEHSWFESFIVLMILLSSGALAF----EDIYIERKKTIKIILEYADKIFTYIF 1226
            R  C ++V + WFE   +L+I+L+   L      ED+    ++    ILE  D      F
Sbjct: 90   RSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCN--ILEAFDAFIFAFF 147

Query: 1227 ILEMLLKWIA---YGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLG---PIKSLRT 1280
             +EM++K +A   +G K Y  + W  LDF IV       VA  + YS  G    + ++RT
Sbjct: 148  AVEMVIKMVALGLFGQKCYLGDTWNRLDFFIV-------VAGMMEYSLDGHNVSLSAIRT 200

Query: 1281 LRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG------ 1334
            +R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG      
Sbjct: 201  VRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC 260

Query: 1335 ----------------KFYE----------CINTTDGSRFPASQVPNRSECFALMNVSQN 1368
                             +Y+          C +  D      S +P R E      +   
Sbjct: 261  FLDSAFVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCSHIPGRRELRMPCTLGWE 320

Query: 1369 -----------------VRWK--------------NLKVNFDNVGLGYLSLLQVATFKGW 1397
                             + W               N  +NFDN+G  ++++ QV T +GW
Sbjct: 321  AYTQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGW 380

Query: 1398 TIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLG 1457
              IMY  +D+          +S Y +IYF++ II GSFF +NL + VI   F++ K++  
Sbjct: 381  VDIMYYVMDA----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR-- 428

Query: 1458 GQDIFMTEEQKKYYNAMKKLGS 1479
             +   M E++ ++ +    L S
Sbjct: 429  -ESQLMREQRARHLSNDSTLAS 449



 Score =  127 bits (318), Expect = 1e-28
 Identities = 93/365 (25%), Positives = 168/365 (46%), Gaps = 69/365 (18%)

Query: 102 ATPALYMLSPFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTMNNPPDWTK------NV 155
           A    + L   +  R   ++++ +  F  + M  I+ NC+ + M  P +  +      N+
Sbjct: 76  AATVFFCLGQTTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNI 135

Query: 156 EYTFTGI----YTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVNLGNVS 211
              F       +  E ++K++A G   G+  +L D WN LDF ++V   +   ++  NVS
Sbjct: 136 LEAFDAFIFAFFAVEMVIKMVALGL-FGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVS 194

Query: 212 --ALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 269
             A+RT RVLR L+ I+ +P ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G
Sbjct: 195 LSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 254

Query: 270 NLKHKCFRNSL---ENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSG--QC 324
            L+++CF +S     NN T              R Y+   EG ++  +C    D+G  +C
Sbjct: 255 LLRNRCFLDSAFVRNNNLTF------------LRPYYQTEEGEENPFICSSRRDNGMQKC 302

Query: 325 P----------------EGYT-----------------------CVKIGRNPDYGYTSFD 345
                            E YT                       C     NP  G  +FD
Sbjct: 303 SHIPGRRELRMPCTLGWEAYTQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFD 362

Query: 346 TFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAY 405
              +A++A+F+++T + W ++    + A      I+F+++I +GSF++INL L V+A  +
Sbjct: 363 NIGYAWIAIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 422

Query: 406 EEQNQ 410
            E  Q
Sbjct: 423 SETKQ 427



 Score =  125 bits (313), Expect = 5e-28
 Identities = 99/378 (26%), Positives = 171/378 (45%), Gaps = 76/378 (20%)

Query: 105  ALYMLSPFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTMNNP---PDWTKNV-----E 156
            ALY+ SP +  R    K++ H +F  +++  I  NC+ + +  P   P  T+ V      
Sbjct: 1273 ALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSN 1332

Query: 157  YTFTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVN---------L 207
            Y FT I+  E +VK++A G   GE  +L+  WN LD ++++ + +   V          L
Sbjct: 1333 YIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKIL 1392

Query: 208  GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 267
            G +  LR  R LR L+ IS  PGLK +V  LI S++ + +++++      +F ++G+QLF
Sbjct: 1393 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLF 1452

Query: 268  MGNLKHKCFRNSLENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEG 327
             G                                 FYY EG     +    +   QC   
Sbjct: 1453 KGK--------------------------------FYYCEGPDTRNI----STKAQCRAA 1476

Query: 328  -YTCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAG----------K 376
             Y  V+   N       FD    A ++LF L ++D W N+    L A G           
Sbjct: 1477 HYRWVRRKYN-------FDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHNP 1529

Query: 377  TYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQ-ANIEEAKQKELEFQQMLDRLKKEQE 435
              +++F+  + + SF+++N+ + VV   + +  Q    EEA+++E   ++ L RL++ + 
Sbjct: 1530 WMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRRE---EKRLRRLERRRR 1586

Query: 436  EAEAIAAAAAEYTSIRRS 453
            +A+      A+Y+  RRS
Sbjct: 1587 KAQR-RPYYADYSPTRRS 1603



 Score =  109 bits (273), Expect = 2e-23
 Identities = 80/307 (26%), Positives = 147/307 (47%), Gaps = 30/307 (9%)

Query: 690  EELEESRQKCPPWWYRFAHKFLIWNCSPYWIKF---KKCIYFIVMDPFVDLAITICIVLN 746
            +E EE+R++      R   +       PY+  +   ++ I+ +    ++DL IT  I +N
Sbjct: 1565 QEAEEARRREEKRLRRLERRRRKAQRRPYYADYSPTRRSIHSLCTSHYLDLFITFIICVN 1624

Query: 747  TLFMAMEHHPMTEEFKNVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVT 806
             + M+MEH+   +     L   N VFT +F  E  LKL+A     +F+  WN  D  IV 
Sbjct: 1625 VITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVL 1684

Query: 807  LSLVELFLADVEG----------LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALG 856
            LSL+ + L ++E           + ++R  R+ RV KL K    +  L+  +  ++  +G
Sbjct: 1685 LSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVG 1744

Query: 857  NLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWH--MNDFFHSFLIVFRVLC 914
            NL L+  ++ FI+A +G++LFG+      C  ++ C     H   ++F  +FL +FRV  
Sbjct: 1745 NLGLLFMLLFFIYAALGVELFGR----LECSEDNPCEGLSRHATFSNFGMAFLTLFRVST 1800

Query: 915  GE-WIETMWDCMEVAGQ----------AMCLIVYMMVMVIGNLVVLNLFLALLLSSFSSD 963
            G+ W   M D +    +          A+  + ++  +++   V++N+ +A+L+      
Sbjct: 1801 GDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEES 1860

Query: 964  NLTAIEE 970
            N  A E+
Sbjct: 1861 NKEARED 1867



 Score =  106 bits (264), Expect = 3e-22
 Identities = 75/291 (25%), Positives = 142/291 (48%), Gaps = 38/291 (13%)

Query: 1489 PGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYW--INVVFIIL 1546
            P N+ +     ++T++ FD  ++V I LN VT+ +E+       TE ++    N +F  +
Sbjct: 1279 PQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAI 1338

Query: 1547 FTGECVLKLISL-----RHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVI 1601
            F  E ++K+++L      H Y    WN+ D ++V++S+V + +A           + RV+
Sbjct: 1339 FVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVL 1398

Query: 1602 RLARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM----SNFAY 1657
            RL R  R LR++  A G++ ++  L+ SL  + NI L+      I+ I G+      F Y
Sbjct: 1399 RLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYY 1458

Query: 1658 VKKED----------------GINDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKP 1701
             +  D                 +   +NF+  G +++ LF +++  GW  ++   L++  
Sbjct: 1459 CEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVG 1518

Query: 1702 PDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENF 1752
             D  P + H          NP + + YF+S+++I    V+NM++ V++ENF
Sbjct: 1519 VDQQPVQNH----------NPWM-LLYFISFLLIVSFFVLNMFVGVVVENF 1558



 Score =  103 bits (256), Expect = 2e-21
 Identities = 75/289 (25%), Positives = 140/289 (48%), Gaps = 43/289 (14%)

Query: 1164 GKIWWNIRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFT 1223
            G++W        +IV+  +F   I++ IL+++ ++  E  Y E+ + +   LE ++ +FT
Sbjct: 776  GRLWVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVE--YHEQPEELTNALEISNIVFT 833

Query: 1224 YIFILEMLLKWIAYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRA 1283
             +F LEMLLK +A G   Y  N +   D +IV +S+  +V    G +D G +  LRT R 
Sbjct: 834  SMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIV----GQAD-GGLSVLRTFRL 888

Query: 1284 LRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTT 1343
            LR L+ +     +R  +  L+  + ++     + ++F  IFSI+G++LF  KF    +T 
Sbjct: 889  LRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTG 948

Query: 1344 DGSRFPASQVPNRSECFALMNVSQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYA 1403
            D        VP+R                    NFD++    +++ Q+ T + W +++Y 
Sbjct: 949  D-------TVPDRK-------------------NFDSLLWAIVTVFQILTQEDWNVVLYN 982

Query: 1404 AVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQ 1452
             + S           S +  +YFV  + FG++   NL + ++++ F  +
Sbjct: 983  GMAST----------SSWAALYFVALMTFGNYVLFNLLVAILVEGFQAE 1021



 Score = 92.8 bits (229), Expect = 3e-18
 Identities = 80/345 (23%), Positives = 144/345 (41%), Gaps = 92/345 (26%)

Query: 112  FSPLRRISIKILVHSLFSMLIMCTILTNCIFMTMN--NPP----DWTKNVEYTFTGIYTF 165
            +SP RR    +       + I   I  N I M+M   N P    +  K   Y FT ++ F
Sbjct: 1597 YSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVF 1656

Query: 166  ESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAY----LTEF-------VNLGNVSALR 214
            E+ +K++A GF      F +D WN LD  +++ +     L E        +N   +  +R
Sbjct: 1657 EAALKLVAFGF----RRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMR 1712

Query: 215  TFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHK 274
              R+ R LK + +  G++ ++  ++Q++ ++ ++ +L +    ++A +G++LF G L   
Sbjct: 1713 VLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF-GRL--- 1768

Query: 275  CFRNSLENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIG 334
                                                            +C E   C  + 
Sbjct: 1769 ------------------------------------------------ECSEDNPCEGLS 1780

Query: 335  RNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGK------TYM-----IFFV 383
            R     + +F  F  AFL LFR+ T D W  + + TLR   +      +Y+     ++FV
Sbjct: 1781 R-----HATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFV 1835

Query: 384  VVIFLGSFYLINLILAVVAMAYEEQNQANIEEAK---QKELEFQQ 425
              + +  F L+N+++AV+    EE N+   E+A+   + ELE  Q
Sbjct: 1836 TFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAELDAEIELEMAQ 1880



 Score = 90.1 bits (222), Expect = 2e-17
 Identities = 75/283 (26%), Positives = 129/283 (45%), Gaps = 41/283 (14%)

Query: 1500 LVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTGECVLKLISLR 1559
            +V ++ F   IM+ I +N ++M VE   Q + +T  L   N+VF  +F  E +LKL++  
Sbjct: 789  IVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACG 848

Query: 1560 HY-YFTVGWNIFDFVVVIIS---IVGMFLADLIETYFVSPTLFRVIRLARIGRILRLVKG 1615
               Y    +NIFD ++V+IS   IVG     L            V+R  R+ R+L+LV+ 
Sbjct: 849  PLGYIRNPYNIFDGIIVVISVWEIVGQADGGL-----------SVLRTFRLLRVLKLVRF 897

Query: 1616 AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA---YVKKEDG--INDMFNF 1670
               +R  L  L+ ++  +     LL L +FI++I GM  F     +K + G  + D  NF
Sbjct: 898  LPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNF 957

Query: 1671 ETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFV 1730
            ++   +++ +FQI T   W+ +L                       G     S    YFV
Sbjct: 958  DSLLWAIVTVFQILTQEDWNVVL---------------------YNGMASTSSWAALYFV 996

Query: 1731 SYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYE 1773
            + +     V+ N+ +A+++E F    + +     ED   + +E
Sbjct: 997  ALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTDEDKTSVHFE 1039



 Score = 65.5 bits (158), Expect = 5e-10
 Identities = 44/157 (28%), Positives = 80/157 (50%), Gaps = 8/157 (5%)

Query: 729 IVMDPFVDLAITICIVLNTLFMAM----EHHPMTEEFKNVLAIGNLVFTGIFAAEMVLKL 784
           +V +P+ +    + I+LN + + M    E      E  N+L   +      FA EMV+K+
Sbjct: 96  LVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKM 155

Query: 785 IAMDPYE---YFQVGWNIFDSLIVTLSLVELFLADVE-GLSVLRSFRLLRVFKLAKSWPT 840
           +A+  +    Y    WN  D  IV   ++E  L      LS +R+ R+LR  +     P+
Sbjct: 156 VALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLRPLRAINRVPS 215

Query: 841 LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 877
           + +L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 216 MRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 252



 Score = 55.8 bits (133), Expect = 4e-07
 Identities = 47/165 (28%), Positives = 77/165 (46%), Gaps = 15/165 (9%)

Query: 1500 LVTNQAFDISIMVLICLNMVTMMVEKEGQS----QHMTEVLYWINVVFIILFTGECVLKL 1555
            LV N  F+   M++I LN VT+ + +  +          +L   +      F  E V+K+
Sbjct: 96   LVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKM 155

Query: 1556 ISLRHY----YFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRLARIGRILR 1611
            ++L  +    Y    WN  DF +V+  ++   L    + + VS      IR  R+ R LR
Sbjct: 156  VALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSL----DGHNVS---LSAIRTVRVLRPLR 208

Query: 1612 LVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA 1656
             +     +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 209  AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 253



 Score = 35.8 bits (81), Expect = 0.43
 Identities = 20/101 (19%), Positives = 41/101 (40%), Gaps = 21/101 (20%)

Query: 1665 NDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSV 1724
            N   NF+  G + I +FQ+ T  GW  ++  ++++                     +   
Sbjct: 356  NGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDA---------------------HSFY 394

Query: 1725 GIFYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSE 1765
               YF+  II+    ++N+ + VI   FS   +  ++ + E
Sbjct: 395  NFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMRE 435


>gi|193788534 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 12 [Homo sapiens]
          Length = 2146

 Score =  338 bits (867), Expect = 3e-92
 Identities = 260/885 (29%), Positives = 443/885 (50%), Gaps = 72/885 (8%)

Query: 1024 ENYISNHTLAEMSKGHNFLKEKDKISGFGSSVDKHLMEDSDGQSFIHNPSLTVTVPIAPG 1083
            +N     +L    K     KE+ K++   S   K        Q  +  P++        G
Sbjct: 754  DNLADAESLTSAQKEEEEEKERKKLARTASPEKK--------QELVEKPAV--------G 797

Query: 1084 ESDLENMNAEELSSDSDSE-YSKVRLNRSSSSECSTVDNPLPGE---GEEAEAEPMNSDE 1139
            ES  E +  + +++D +S   +K+ ++    +E +   +P P     GEE E EP     
Sbjct: 798  ESKEEKIELKSITADGESPPATKINMDDLQPNE-NEDKSPYPNPETTGEEDEEEPEMPVG 856

Query: 1140 P------EACFTDGCVRRFSCCQVNIESGKGKIWWNIRKTCYKIVEHSWFESFIVLMILL 1193
            P      E    +  V         I S   +     R  C++IV  + F + I+  ILL
Sbjct: 857  PRPRPLSELHLKEKAVPMPEASAFFIFSSNNRF----RLQCHRIVNDTIFTNLILFFILL 912

Query: 1194 SSGALAFEDIYIERKKTIKIILEYADKIFTYIFILEMLLKWIAYGY----KTYFTNAWCW 1249
            SS +LA ED  ++       IL  AD +FT IF LE++LK  AYG      ++  N +  
Sbjct: 913  SSISLAAEDP-VQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNI 971

Query: 1250 LDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPS 1309
            LD L+V VSL++    +   S +  +K LR LR LRPLRA++R +G++ VV  +  AI +
Sbjct: 972  LDLLVVSVSLISFGIQS---SAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRT 1028

Query: 1310 IMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDGSRFPASQVPNRSECFALMNVSQNV 1369
            I N+++V  +   +F+ +GV LF GK Y C   +D S+   ++       +    V   +
Sbjct: 1029 IGNIVIVTTLLQFMFACIGVQLFKGKLYTC---SDSSKQTEAECKGNYITYKDGEVDHPI 1085

Query: 1370 ----RWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIY 1425
                 W+N K +FDNV    ++L  V+TF+GW  ++Y ++DS   DK P Y Y + + I+
Sbjct: 1086 IQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIF 1145

Query: 1426 FVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKP-QK 1484
            F+++II  +FF +N+F+G +I  F +Q    G Q+    E  K     ++     +P ++
Sbjct: 1146 FIIYIIIIAFFMMNIFVGFVIVTFQEQ----GEQEYKNCELDKNQRQCVEYALKARPLRR 1201

Query: 1485 PIPRPGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFI 1544
             IP+  N+ Q  ++ +V +  F+  + VLI LN + + ++  GQS      +  +N++F 
Sbjct: 1202 YIPK--NQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFT 1259

Query: 1545 ILFTGECVLKLISLR-HYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRL 1603
             LFT E +LKLI+ +  +YF   WN FD ++V+ SIV + + ++      S       RL
Sbjct: 1260 GLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRL 1319

Query: 1604 ARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKED- 1662
             R+ R+++L+   +GIRTLL+  + S  AL  + LL+ ++ FIYA+ GM  F  +   D 
Sbjct: 1320 FRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDT 1379

Query: 1663 -GINDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGD--C 1719
              IN   NF+TF  +++ LF+  T   W  ++   +  K   C P+   P +S EG+  C
Sbjct: 1380 TEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGK--KCAPES-EPSNSTEGETPC 1436

Query: 1720 GNPSVGIFYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWEKFD 1779
            G+ S  +FYF+S+ ++   +++N+++AVI++NF   T +    L     + F  +W ++D
Sbjct: 1437 GS-SFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRD-WSILGPHHLDEFKRIWAEYD 1494

Query: 1780 PDATQFIEFSKLSDFAAALDPPLLIAK--PNKV---QLIAMDLPMVSGDRIHCLDILFAF 1834
            P+A   I+   +      + PPL   K  P++V   +L++M++P+ S   +     LFA 
Sbjct: 1495 PEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFAL 1554

Query: 1835 TK---RVLGESGEMDSLRSQ-MEERFMSANPSKVSYEPITTTLKR 1875
             +   R+  E G   S   Q  E+ F  A   + + E +   +K+
Sbjct: 1555 VRTALRIKTEEGPSPSEAHQGAEDPFRPAGNLEQANEELRAIIKK 1599



 Score =  174 bits (441), Expect = 8e-43
 Identities = 176/696 (25%), Positives = 293/696 (42%), Gaps = 132/696 (18%)

Query: 1170 IRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYI----ERKKTIKIILEYADKIFTYI 1225
            IR+ C  IVE   FE  I+L I  +  ALA   IYI    +        LE  + +F  I
Sbjct: 113  IRRACISIVEWKPFEIIILLTIFANCVALA---IYIPFPEDDSNATNSNLERVEYLFLII 169

Query: 1226 FILEMLLKWIAYGY----KTYFTNAWCWLDFLIVDVSLVTLV---------ANTLGYSDL 1272
            F +E  LK IAYG       Y  N W  LDF+IV V L + +         AN LG    
Sbjct: 170  FTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGA 229

Query: 1273 G-PIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNL 1331
            G  +K+LR  R LRPLR +S    ++VV+N++I A+  ++++ L+ L   +I++I+G+ L
Sbjct: 230  GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLEL 289

Query: 1332 FAGKFYE-CINTTDGSRFPASQVPNRSECFALMNVSQNVR--------WKNLK---VNFD 1379
            F GK ++ C N    +  PA   P  S C       +  +        W   K    NFD
Sbjct: 290  FMGKMHKTCYNQEGIADVPAEDDP--SPCALETGHGRQCQNGTVCKPGWDGPKHGITNFD 347

Query: 1380 NVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLN 1439
            N     L++ Q  T +GWT ++Y   D+V  D         + +IYFV  II GSFF LN
Sbjct: 348  NFAFAMLTVFQCITMEGWTDVLYWVNDAVGRD---------WPWIYFVTLIIIGSFFVLN 398

Query: 1440 LFIGVIIDNFNQQKKKLGGQ-DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKIQGCIF 1498
            L +GV+   F+++++K   + D     E+++    +K       Q     P N+ +G   
Sbjct: 399  LVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDE 458

Query: 1499 DLVTNQAFDISIMVLI--------------CLNMVTMMVEKEGQSQH------------- 1531
            +   N +   S    +              C   +   + K   S++             
Sbjct: 459  EKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCR 518

Query: 1532 ---MTEVLYWINVVFIILFTGECVLKLISLRHYYFTVGWNIFDFVVVIISIVGMFLADL- 1587
                + V YW+ +  + L T      L     +Y    W          +++ +F A++ 
Sbjct: 519  AAVKSNVFYWLVIFLVFLNT------LTIASEHYNQPNWLTEVQDTANKALLALFTAEML 572

Query: 1588 -------IETYFVS--------------------------PTLFRVIRLARIGRILRLVK 1614
                   ++ YFVS                          P    V+R  R+ RI ++ +
Sbjct: 573  LKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITR 632

Query: 1615 GAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEDGIND-MFNFETF 1673
                +  L+ +L+ S+ ++ ++ LLLFL + I+++ GM  F      D +      F+ F
Sbjct: 633  YWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNF 692

Query: 1674 GNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYI 1733
              S++ +FQI T   W+ ++           D    + G S  G      +   YF+   
Sbjct: 693  PQSLLTVFQILTGEDWNSVM----------YDGIMAYGGPSFPG-----MLVCIYFIILF 737

Query: 1734 IISFLVVVNMYIAVILENFSVATEESTEPLSEDDFE 1769
            I    +++N+++A+ ++N + A E  T    E++ E
Sbjct: 738  ICGNYILLNVFLAIAVDNLADA-ESLTSAQKEEEEE 772



 Score =  160 bits (404), Expect = 2e-38
 Identities = 106/355 (29%), Positives = 180/355 (50%), Gaps = 50/355 (14%)

Query: 105 ALYMLSPFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTMNNP-PDWTKN--------V 155
           AL  L+  +P+RR  I I+    F ++I+ TI  NC+ + +  P P+   N        V
Sbjct: 103 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 162

Query: 156 EYTFTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVN--------- 206
           EY F  I+T E+ +K++A G       +LR+ WN LDF+++V    +  +          
Sbjct: 163 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 222

Query: 207 -LG------NVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVF 259
            LG      +V ALR FRVLR L+ +S +P L+ ++ ++I+++  L  + +L +F + ++
Sbjct: 223 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282

Query: 260 ALIGLQLFMGNLKHKCFRNSLENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFST 319
           A+IGL+LFMG +   C+     N E +  +                     D   C   T
Sbjct: 283 AIIGLELFMGKMHKTCY-----NQEGIADV-----------------PAEDDPSPCALET 320

Query: 320 DSG-QCPEGYTCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKTY 378
             G QC  G  C      P +G T+FD F++A L +F+ +T + W ++      A G+ +
Sbjct: 321 GHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDW 380

Query: 379 -MIFFVVVIFLGSFYLINLILAVVAMAY-EEQNQANIEEAKQKELEFQQMLDRLK 431
             I+FV +I +GSF+++NL+L V++  + +E+ +A      QK  E QQ+ + LK
Sbjct: 381 PWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLK 435



 Score =  130 bits (328), Expect = 1e-29
 Identities = 100/324 (30%), Positives = 168/324 (51%), Gaps = 30/324 (9%)

Query: 705  RFAHKFLIWNCSPYWIKF-----KKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTE 759
            R AH+      S YW ++     +KC   +  + F  L I + + LNTL +A EH+    
Sbjct: 492  RLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFL-VFLNTLTIASEHYNQPN 550

Query: 760  EFKNVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADVE- 818
                V    N     +F AEM+LK+ ++    YF   +N FD  +V   ++E  L + + 
Sbjct: 551  WLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKI 610

Query: 819  ----GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGM 874
                G+SVLR  RLLR+FK+ + W +L+ L+  + NSV ++ +L L+L + + IF+++GM
Sbjct: 611  MSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGM 670

Query: 875  QLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAG---- 929
            QLFG  +        D+    R   ++F  S L VF++L GE W   M+D +   G    
Sbjct: 671  QLFGGKFN------FDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSF 724

Query: 930  QAMCLIVYMMVMVI-GNLVVLNLFLALLLSSFS-SDNLTAI--EEDPDANNLQIAVTRIK 985
              M + +Y +++ I GN ++LN+FLA+ + + + +++LT+   EE+ +    ++A T   
Sbjct: 725  PGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASP 784

Query: 986  KGINYVKQTLREFILKAFSKKPKI 1009
            +     KQ L E      SK+ KI
Sbjct: 785  E----KKQELVEKPAVGESKEEKI 804



 Score =  123 bits (309), Expect = 2e-27
 Identities = 78/266 (29%), Positives = 139/266 (52%), Gaps = 40/266 (15%)

Query: 726  IYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAIGNLVFTGIFAAEMVLKLI 785
            ++++V   + +  + + I+LNT+ +AM+H+  +  FK  + I N++FTG+F  EM+LKLI
Sbjct: 1212 VWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLI 1271

Query: 786  AMDPYEYFQVGWNIFDSLIVTLSLVELFLADVE--------GLSVLRSFRLLRVFKLAKS 837
            A  P  YF   WN FD+LIV  S+V++ + +V          ++  R FR++R+ KL   
Sbjct: 1272 AFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLVKLLSR 1331

Query: 838  WPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRW 897
               +  L+     S  AL  + L++ ++ FI+AV+GMQ+FGK        +ND   + R 
Sbjct: 1332 GEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGK------IALNDTTEINR- 1384

Query: 898  HMNDFFHSF----LIVFRVLCGE-WIETMWDCM------------------EVAGQAMCL 934
              N+ F +F    L++FR   GE W + M  CM                     G +  +
Sbjct: 1385 --NNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAV 1442

Query: 935  IVYMMVMVIGNLVVLNLFLALLLSSF 960
              ++   ++   +++NLF+A+++ +F
Sbjct: 1443 FYFISFYMLCAFLIINLFVAVIMDNF 1468



 Score =  102 bits (253), Expect = 5e-21
 Identities = 79/325 (24%), Positives = 148/325 (45%), Gaps = 42/325 (12%)

Query: 1168 WN--IRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYI 1225
            WN   R+ C   V+ + F   ++ ++ L++  +A E  +  +   +  + + A+K    +
Sbjct: 509  WNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASE--HYNQPNWLTEVQDTANKALLAL 566

Query: 1226 FILEMLLKWIAYGYKTYFTNAWCWLD-FLIVDVSLVTLVANTLGYSDLGPIKSLRTLRAL 1284
            F  EMLLK  + G + YF + +   D F++    L T++  T   S LG I  LR +R L
Sbjct: 567  FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLG-ISVLRCVRLL 625

Query: 1285 RPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTD 1344
            R  +    +  +  +V +L+ ++ SI ++LL+  +F +IFS++G+ LF GKF        
Sbjct: 626  RIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF-------- 677

Query: 1345 GSRFPASQVPNRSECFALMNVSQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAA 1404
                      N  E             +  +  FDN     L++ Q+ T + W  +MY  
Sbjct: 678  ----------NFDEM------------QTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDG 715

Query: 1405 VDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMT 1464
            + +      P     + + IYF++  I G++  LN+F+ + +DN    +     Q     
Sbjct: 716  IMAYGGPSFP----GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQK--EE 769

Query: 1465 EEQKKYYNAMKKLGSKKPQKPIPRP 1489
            EE+K+     +    +K Q+ + +P
Sbjct: 770  EEEKERKKLARTASPEKKQELVEKP 794



 Score =  100 bits (250), Expect = 1e-20
 Identities = 96/407 (23%), Positives = 180/407 (44%), Gaps = 70/407 (17%)

Query: 39   KKDDDEEAPKPSSDLEAGKQLPFIYGDIPPGMVSEPLEDLDPYYADKKTFIVLNKGKTIF 98
            + +D    P P +  E  ++ P    ++P G    PL +L      K+  + + +    F
Sbjct: 830  ENEDKSPYPNPETTGEEDEEEP----EMPVGPRPRPLSELHL----KEKAVPMPEASAFF 881

Query: 99   RFNATPALYMLSPFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTMNNPPDWTK----- 153
             F++          +  R    +I+  ++F+ LI+  IL + I +   +P   T      
Sbjct: 882  IFSSN---------NRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHI 932

Query: 154  --NVEYTFTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVN---LG 208
              N +Y FT I+T E ++K+ A G  + + +F R+ +N LD +V+  + ++  +    + 
Sbjct: 933  LGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAIN 992

Query: 209  NVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFM 268
             V  LR  RVLR L+ I+   GLK +V  +  +++ + +++I+T     +FA IG+QLF 
Sbjct: 993  VVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFK 1052

Query: 269  GNLKHKCFRNSLENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGY 328
            G L + C  +S +     +              Y  Y +G  D  +          P  +
Sbjct: 1053 GKL-YTCSDSSKQTEAECKG------------NYITYKDGEVDHPIIQ--------PRSW 1091

Query: 329  TCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRA----AGKTY------ 378
               K           FD    A +ALF + T + W  L  +++ +     G  Y      
Sbjct: 1092 ENSKF---------DFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEI 1142

Query: 379  MIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANIEEAKQKELEFQQ 425
             IFF++ I + +F+++N+ +  V + ++EQ +   +E K  EL+  Q
Sbjct: 1143 SIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGE---QEYKNCELDKNQ 1186



 Score = 86.3 bits (212), Expect = 3e-16
 Identities = 95/353 (26%), Positives = 151/353 (42%), Gaps = 48/353 (13%)

Query: 1464 TEEQKKYYNAMKKLGSKKPQKPIPRP------GNKIQGCIFDLVTNQAFDISIMVLICLN 1517
            T+ +++ Y   KK GS    +P PR        N I+     +V  + F+I I++ I  N
Sbjct: 79   TQRKRQQYGKPKKQGSTTATRP-PRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFAN 137

Query: 1518 MVTMMVE---KEGQSQHMTEVLYWINVVFIILFTGECVLKLISLR-----HYYFTVGWNI 1569
             V + +     E  S      L  +  +F+I+FT E  LK+I+       + Y   GWN+
Sbjct: 138  CVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNL 197

Query: 1570 FDFVVVIISIVGMFL-----ADLIETYFVSPTLFRV--IRLARIGRILRLVKGAKGIRTL 1622
             DF++V++ +    L     AD           F V  +R  R+ R LRLV G   ++ +
Sbjct: 198  LDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVV 257

Query: 1623 LFALMMSLPALFNIGLLLFLVMFIYAIFGMSNF-----AYVKKEDGINDM--------FN 1669
            L +++ ++  L +I LL+  V+ IYAI G+  F          ++GI D+          
Sbjct: 258  LNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCA 317

Query: 1670 FETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCG-----NPSV 1724
             ET G+   C        GWDG    I N          V    ++EG        N +V
Sbjct: 318  LET-GHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAV 376

Query: 1725 G----IFYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYE 1773
            G      YFV+ III    V+N+ + V+   FS   +E  +  +  DF+   E
Sbjct: 377  GRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFS---KEREKAKARGDFQKLRE 426



 Score = 84.0 bits (206), Expect = 1e-15
 Identities = 75/299 (25%), Positives = 132/299 (44%), Gaps = 60/299 (20%)

Query: 723 KKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNV----LAIGNLVFTGIFAA 778
           + CI  +   PF ++ I + I  N + +A+ + P  E+  N     L     +F  IF  
Sbjct: 115 RACISIVEWKPF-EIIILLTIFANCVALAI-YIPFPEDDSNATNSNLERVEYLFLIIFTV 172

Query: 779 EMVLKLIA----MDPYEYFQVGWNIFDSLIVTLSLVELFLADVE---------------G 819
           E  LK+IA      P  Y + GWN+ D +IV + L    L                    
Sbjct: 173 EAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFD 232

Query: 820 LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-G 878
           +  LR+FR+LR  +L    P+L +++  I  ++  L ++ L++  ++ I+A++G++LF G
Sbjct: 233 VKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMG 292

Query: 879 KSYKECV-------CKINDD---CTL---------------PRW--------HMNDFFHS 905
           K +K C            DD   C L               P W        + ++F  +
Sbjct: 293 KMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFA 352

Query: 906 FLIVFRVLCGE-WIETMWDCMEVAGQAMCLIVYMMVMVIGNLVVLNLFLALLLSSFSSD 963
            L VF+ +  E W + ++   +  G+    I ++ +++IG+  VLNL L +L   FS +
Sbjct: 353 MLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKE 411



 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 47/169 (27%), Positives = 89/169 (52%), Gaps = 8/169 (4%)

Query: 721  KFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKN-VLAIGNLVFTGIFAAE 779
            +F+   + IV D      I   I+L+++ +A E       F+N +L   + VFT IF  E
Sbjct: 888  RFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLE 947

Query: 780  MVLKLIAMDPY----EYFQVGWNIFDSLIVTLSLVELFLAD--VEGLSVLRSFRLLRVFK 833
            ++LK+ A   +     + +  +NI D L+V++SL+   +    +  + +LR  R+LR  +
Sbjct: 948  IILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLR 1007

Query: 834  LAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSY 881
                   L  +++ +  ++  +GN+ +V  ++ F+FA +G+QLF GK Y
Sbjct: 1008 AINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLY 1056



 Score = 62.4 bits (150), Expect = 4e-09
 Identities = 80/383 (20%), Positives = 148/383 (38%), Gaps = 75/383 (19%)

Query: 126 SLFSMLIMCTILTNCIFMTMN--NPPDWTKNVEYT----FTGIYTFESLVKILARGFCVG 179
           ++F  L++  +  N + +     N P+W   V+ T       ++T E L+K+    + +G
Sbjct: 524 NVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKM----YSLG 579

Query: 180 EFTFLRDPWNWLDFVVIVFAYL------TEFVNLGNVSALRTFRVLRALKTISVIPGLKT 233
              +    +N  D  V+    L      T+ ++   +S LR  R+LR  K       L  
Sbjct: 580 LQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSN 639

Query: 234 IVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETLESIMNTL 293
           +V +L+ SV+ ++ +++L    + +F+L+G+QLF G            N + +++  +T 
Sbjct: 640 LVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF----------NFDEMQTRRSTF 689

Query: 294 ESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLA 353
           ++                +LL  F   +G   E +  V       YG  SF         
Sbjct: 690 DN-------------FPQSLLTVFQILTG---EDWNSVMYDGIMAYGGPSF--------- 724

Query: 354 LFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVA---MAYEEQNQ 410
                                G    I+F+++   G++ L+N+ LA+        E    
Sbjct: 725 --------------------PGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTS 764

Query: 411 ANIEEAKQKELEFQQMLDRLKKEQEEAEAIAAAAAEYTSIRRSRIMGLSESSSETSKLSS 470
           A  EE ++KE +        +K+QE  E  A   ++   I    I    ES   T K++ 
Sbjct: 765 AQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPAT-KINM 823

Query: 471 KSAKERRNRRKKKNQKKLSSGEE 493
              +   N  K       ++GEE
Sbjct: 824 DDLQPNENEDKSPYPNPETTGEE 846



 Score = 57.8 bits (138), Expect = 1e-07
 Identities = 62/275 (22%), Positives = 109/275 (39%), Gaps = 100/275 (36%)

Query: 159  FTGIYTFESLVKILA----RGFCVGEFTFLRDPWNWLDFVVIVFAY----LTEFVNLG-- 208
            FTG++T E ++K++A      FC        D WN  D +++V +     +TE  N    
Sbjct: 1258 FTGLFTVEMILKLIAFKPKHYFC--------DAWNTFDALIVVGSIVDIAITEVNNAEEN 1309

Query: 209  ---NVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQ 265
               +++  R FRV+R +K +S   G++T++   I+S + L  V +L V    ++A+IG+Q
Sbjct: 1310 SRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQ 1369

Query: 266  LFMGNLKHKCFRNSLENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCP 325
            +F            +  N+T E                                      
Sbjct: 1370 VF----------GKIALNDTTE-------------------------------------- 1381

Query: 326  EGYTCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTL-------------- 371
                   I RN      +F TF  A L LFR  T + W+++    +              
Sbjct: 1382 -------INRN-----NNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNS 1429

Query: 372  ----RAAGKTYMIFFVVVIF-LGSFYLINLILAVV 401
                   G ++ +F+ +  + L +F +INL +AV+
Sbjct: 1430 TEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVI 1464


>gi|53832009 calcium channel, voltage-dependent, T type, alpha 1H
            subunit isoform a [Homo sapiens]
          Length = 2353

 Score =  337 bits (865), Expect = 5e-92
 Identities = 207/659 (31%), Positives = 368/659 (55%), Gaps = 48/659 (7%)

Query: 1171 RKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILEM 1230
            R +C K++ H  F+  +++ I L+   +A E   I+   T ++ L  ++ IFT IF+ EM
Sbjct: 1284 RVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEM 1343

Query: 1231 LLKWIAYGYKT----YFTNAWCWLDFLIVDVSLVTLV---ANTLGYSDLGPIKSLRTLRA 1283
            ++K +A G  +    Y  ++W  LD L+V VSLV +V   A+  G   LG ++ LR LR 
Sbjct: 1344 MVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRT 1403

Query: 1284 LRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTT 1343
            LRPLR +SR  G+++VV  LI ++  I N++L+C  F++IF I+GV LF GKFY C    
Sbjct: 1404 LRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPD 1463

Query: 1344 DGSRFPASQVPNRSECFALMNVSQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYA 1403
                     +  +++C A      + RW   K NFDN+G   +SL  +++  GW  IMY 
Sbjct: 1464 ------TRNISTKAQCRAA-----HYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYD 1512

Query: 1404 AVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFM 1463
             +D+V VD+QP   ++ +M +YF+ F++  SFF LN+F+GV+++NF++ ++    ++   
Sbjct: 1513 GLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEA-R 1571

Query: 1464 TEEQKKYYNAMKKLGSKKP-----QKPIPRPGNKIQGCIFDLVTNQAFDISIMVLICLNM 1518
              E+K+     ++  S  P     ++P     +  +  I  L T+   D+ I  +IC+N+
Sbjct: 1572 RREEKRLRRLERRRRSTFPSPEAQRRPYYADYSPTRRSIHSLCTSHYLDLFITFIICVNV 1631

Query: 1519 VTMMVEKEGQSQHMTEVLYWINVVFIILFTGECVLKLISLR-HYYFTVGWNIFDFVVVII 1577
            +TM +E   Q + + E L + N VF I+F  E  LKL++     +F   WN  D  +V++
Sbjct: 1632 ITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLL 1691

Query: 1578 SIVGMFL--ADLIETYFVSPTLFRVIRLARIGRILRLVKGAKGIRTLLFALMMSLPALFN 1635
            S++G+ L   ++     ++PT+ R++R+ RI R+L+L+K A G+R LL  ++ +LP + N
Sbjct: 1692 SLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGN 1751

Query: 1636 IGLLLFLVMFIYAIFGMSNFAYVK-KED----GINDMFNFETFGNSMICLFQITTSAGWD 1690
            +GLL  L+ FIYA  G+  F  ++  ED    G++    F  FG + + LF+++T   W+
Sbjct: 1752 LGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWN 1811

Query: 1691 GLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILE 1750
            G++   L     +C  +  H  S +      P++   YFV++++++  V+VN+ +AV+++
Sbjct: 1812 GIMKDTLR----ECSREDKHCLSYL------PALSPVYFVTFVLVAQFVLVNVVVAVLMK 1861

Query: 1751 NFSVATEESTEPLSEDDFEMFYEVWEKFDPDATQFIEFSK---LSDFAAALDPPLLIAK 1806
            +   + +E+ E  +E D E+  E+ +   P + + ++  +     +   A D P L+A+
Sbjct: 1862 HLEESNKEARED-AELDAEIELEMAQ--GPGSARRVDADRPPLPQESPGARDAPNLVAR 1917



 Score =  158 bits (399), Expect = 6e-38
 Identities = 195/892 (21%), Positives = 370/892 (41%), Gaps = 173/892 (19%)

Query: 121  KILVHSLFSMLIMCTILTNCIFMTMN---NPPDWTKNVEYT---FTGIYTFESLVKILAR 174
            +I+    FS  IM  IL N + M +     P + T  +E +   FT ++  E L+K+LA 
Sbjct: 788  RIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLA- 846

Query: 175  GFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVNL--GNVSALRTFRVLRALKTISVIPGLK 232
                G   ++R+P+N  D +++V + + E V    G +S LRTFR+LR LK +  +P L+
Sbjct: 847  ---CGPLGYIRNPYNIFDGIIVVIS-VWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALR 902

Query: 233  TIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETLESIMNT 292
              +  L++++  ++    L +  + +F+++G+ LF                         
Sbjct: 903  RQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLF------------------------- 937

Query: 293  LESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFL 352
                           G K +L     TD+G              PD    +FD+  WA +
Sbjct: 938  ---------------GCKFSL----KTDTGDTV-----------PDR--KNFDSLLWAIV 965

Query: 353  ALFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQAN 412
             +F+++TQ+ W  +    + +      ++FV ++  G++ L NL++A++   ++ +  AN
Sbjct: 966  TVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDAN 1025

Query: 413  IEEAKQKE--LEFQQMLDRLKKEQEEAEAIAAAAAEYTSIRRSRIMGLSESSSETSKLSS 470
              +  + +  + F++   +L++ Q     + + A          + G    S      ++
Sbjct: 1026 RSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAVT----PNGHLEGRGSLSPPLIMCTA 1081

Query: 471  KSAKERRNRRKKKNQKKLSSGEEKGDAEKLSKSESEDSIRRKSFHLGVEGHRRAHEKRLS 530
             +          K+   L +     D+ + S S  +  +          G ++      S
Sbjct: 1082 ATPMPT-----PKSSPFLDAAPSLPDSRRGSSSSGDPPL----------GDQKPPASLRS 1126

Query: 531  TPNQSPLSIRGSLFSARRSSRTSLF---SFKGRGRDIGSETEFADDEHSIFGDNESRRGS 587
            +P  +P    G+ +S+RRSS +SL    S K RG+  G        E     D+E+  G 
Sbjct: 1127 SPC-APWGPSGA-WSSRRSSWSSLGRAPSLKRRGQ-CGERESLLSGEGKGSTDDEAEDGR 1183

Query: 588  LFV-PHRPQERRSSNISQASRSPPMLPVNGKMHSAVDCNGVVSLVDGRSALMLPNGQLLP 646
                P     RR+ ++      P  LP         D +G V        + LP+   L 
Sbjct: 1184 AAPGPRATPLRRAESLDPRPLRPAALPPT----KCRDRDGQV--------VALPSDFFL- 1230

Query: 647  EGTTNQIHKKRRCSSYLLSEDMLNDPNLRQRAMSRASILTNTVEELEESRQKCPPWWYRF 706
                       R  S+      L+D +     +    +L           +   P W R 
Sbjct: 1231 -----------RIDSHREDAAELDDDSEDSCCLRLHKVL-----------EPYKPQWCRS 1268

Query: 707  AHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEH---HPMTEEFKN 763
               + ++  SP   +F+     ++     D  + + I LN + +A+E     P + E + 
Sbjct: 1269 REAWALYLFSPQ-NRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTE-RV 1326

Query: 764  VLAIGNLVFTGIFAAEMVLKLIAMD----PYEYFQVGWNIFDSLIVTLSLVELFLADVEG 819
             L++ N +FT IF AEM++K++A+      + Y Q  WN+ D L+V +SLV++ +A    
Sbjct: 1327 FLSVSNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASA 1386

Query: 820  --------LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAV 871
                    L VLR  R LR  ++    P L ++++ + +S+  +GN+ L+      IF +
Sbjct: 1387 GGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGI 1446

Query: 872  VGMQLF-GKSY-----------KECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGE--W 917
            +G+QLF GK Y            +  C+      + R +  D     L+   VL  +  W
Sbjct: 1447 LGVQLFKGKFYYCEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGW 1506

Query: 918  IETMWDCMEVAG---------QAMCLIVYMMVMVIGNLVVLNLFLALLLSSF 960
            +  M+D ++  G             L+ ++  ++I +  VLN+F+ +++ +F
Sbjct: 1507 VNIMYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENF 1558



 Score =  143 bits (361), Expect = 1e-33
 Identities = 86/258 (33%), Positives = 144/258 (55%), Gaps = 9/258 (3%)

Query: 719  WIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAIGNLVFTGIFAA 778
            W+ F   +  IV   +    I + I++NTL M +E+H   EE  N L I N+VFT +FA 
Sbjct: 779  WVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFAL 838

Query: 779  EMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADVEGLSVLRSFRLLRVFKLAKSW 838
            EM+LKL+A  P  Y +  +NIFD +IV +S+ E+      GLSVLR+FRLLRV KL +  
Sbjct: 839  EMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFL 898

Query: 839  PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLP-RW 897
            P L   + ++  ++  +     +L + +FIF+++GM LFG  +     K +   T+P R 
Sbjct: 899  PALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFS---LKTDTGDTVPDRK 955

Query: 898  HMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQAMCLIVYMMVMVIGNLVVLNLFLALL 956
            + +    + + VF++L  E W   +++ M  +  +   + ++ +M  GN V+ NL +A+L
Sbjct: 956  NFDSLLWAIVTVFQILTQEDWNVVLYNGM-ASTSSWAALYFVALMTFGNYVLFNLLVAIL 1014

Query: 957  LSSFSSD---NLTAIEED 971
            +  F ++   N +  +ED
Sbjct: 1015 VEGFQAEGDANRSDTDED 1032



 Score =  137 bits (344), Expect = 1e-31
 Identities = 107/382 (28%), Positives = 170/382 (44%), Gaps = 95/382 (24%)

Query: 1171 RKTCYKIVEHSWFESFIVLMILLSSGALAF----EDIYIERKKTIKIILEYADKIFTYIF 1226
            R  C ++V + WFE   +L+I+L+   L      ED+    ++    ILE  D      F
Sbjct: 90   RSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCN--ILEAFDAFIFAFF 147

Query: 1227 ILEMLLKWIA---YGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLG---PIKSLRT 1280
             +EM++K +A   +G K Y  + W  LDF IV       VA  + YS  G    + ++RT
Sbjct: 148  AVEMVIKMVALGLFGQKCYLGDTWNRLDFFIV-------VAGMMEYSLDGHNVSLSAIRT 200

Query: 1281 LRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG------ 1334
            +R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG      
Sbjct: 201  VRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC 260

Query: 1335 ----------------KFYE----------CINTTDGSRFPASQVPNRSECFALMNVSQN 1368
                             +Y+          C +  D      S +P R E      +   
Sbjct: 261  FLDSAFVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCSHIPGRRELRMPCTLGWE 320

Query: 1369 -----------------VRWK--------------NLKVNFDNVGLGYLSLLQVATFKGW 1397
                             + W               N  +NFDN+G  ++++ QV T +GW
Sbjct: 321  AYTQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGW 380

Query: 1398 TIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLG 1457
              IMY  +D+          +S Y +IYF++ II GSFF +NL + VI   F++ K++  
Sbjct: 381  VDIMYYVMDA----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR-- 428

Query: 1458 GQDIFMTEEQKKYYNAMKKLGS 1479
             +   M E++ ++ +    L S
Sbjct: 429  -ESQLMREQRARHLSNDSTLAS 449



 Score =  127 bits (318), Expect = 1e-28
 Identities = 93/365 (25%), Positives = 168/365 (46%), Gaps = 69/365 (18%)

Query: 102 ATPALYMLSPFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTMNNPPDWTK------NV 155
           A    + L   +  R   ++++ +  F  + M  I+ NC+ + M  P +  +      N+
Sbjct: 76  AATVFFCLGQTTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNI 135

Query: 156 EYTFTGI----YTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVNLGNVS 211
              F       +  E ++K++A G   G+  +L D WN LDF ++V   +   ++  NVS
Sbjct: 136 LEAFDAFIFAFFAVEMVIKMVALGL-FGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVS 194

Query: 212 --ALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 269
             A+RT RVLR L+ I+ +P ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G
Sbjct: 195 LSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 254

Query: 270 NLKHKCFRNSL---ENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSG--QC 324
            L+++CF +S     NN T              R Y+   EG ++  +C    D+G  +C
Sbjct: 255 LLRNRCFLDSAFVRNNNLTF------------LRPYYQTEEGEENPFICSSRRDNGMQKC 302

Query: 325 P----------------EGYT-----------------------CVKIGRNPDYGYTSFD 345
                            E YT                       C     NP  G  +FD
Sbjct: 303 SHIPGRRELRMPCTLGWEAYTQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFD 362

Query: 346 TFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAY 405
              +A++A+F+++T + W ++    + A      I+F+++I +GSF++INL L V+A  +
Sbjct: 363 NIGYAWIAIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 422

Query: 406 EEQNQ 410
            E  Q
Sbjct: 423 SETKQ 427



 Score =  122 bits (305), Expect = 5e-27
 Identities = 99/380 (26%), Positives = 169/380 (44%), Gaps = 74/380 (19%)

Query: 105  ALYMLSPFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTMNNP---PDWTKNV-----E 156
            ALY+ SP +  R    K++ H +F  +++  I  NC+ + +  P   P  T+ V      
Sbjct: 1273 ALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSN 1332

Query: 157  YTFTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVN---------L 207
            Y FT I+  E +VK++A G   GE  +L+  WN LD ++++ + +   V          L
Sbjct: 1333 YIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKIL 1392

Query: 208  GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 267
            G +  LR  R LR L+ IS  PGLK +V  LI S++ + +++++      +F ++G+QLF
Sbjct: 1393 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLF 1452

Query: 268  MGNLKHKCFRNSLENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEG 327
             G                                 FYY EG         ST +      
Sbjct: 1453 KGK--------------------------------FYYCEGPDTR---NISTKAQCRAAH 1477

Query: 328  YTCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAG----------KT 377
            Y  V+   N       FD    A ++LF L ++D W N+    L A G            
Sbjct: 1478 YRWVRRKYN-------FDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHNPW 1530

Query: 378  YMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQ-ANIEEAKQKELEFQQMLDRLKKE--- 433
             +++F+  + + SF+++N+ + VV   + +  Q    EEA+++E +  + L+R ++    
Sbjct: 1531 MLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLERRRRSTFP 1590

Query: 434  QEEAEAIAAAAAEYTSIRRS 453
              EA+      A+Y+  RRS
Sbjct: 1591 SPEAQR-RPYYADYSPTRRS 1609



 Score =  108 bits (270), Expect = 5e-23
 Identities = 75/280 (26%), Positives = 137/280 (48%), Gaps = 30/280 (10%)

Query: 717  PYWIKF---KKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAIGNLVFT 773
            PY+  +   ++ I+ +    ++DL IT  I +N + M+MEH+   +     L   N VFT
Sbjct: 1598 PYYADYSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFT 1657

Query: 774  GIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADVEG----------LSVL 823
             +F  E  LKL+A     +F+  WN  D  IV LSL+ + L ++E           + ++
Sbjct: 1658 IVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIM 1717

Query: 824  RSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKE 883
            R  R+ RV KL K    +  L+  +  ++  +GNL L+  ++ FI+A +G++LFG+    
Sbjct: 1718 RVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGR---- 1773

Query: 884  CVCKINDDCTLPRWH--MNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQ---------- 930
              C  ++ C     H   ++F  +FL +FRV  G+ W   M D +    +          
Sbjct: 1774 LECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLP 1833

Query: 931  AMCLIVYMMVMVIGNLVVLNLFLALLLSSFSSDNLTAIEE 970
            A+  + ++  +++   V++N+ +A+L+      N  A E+
Sbjct: 1834 ALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEARED 1873



 Score =  106 bits (264), Expect = 3e-22
 Identities = 75/291 (25%), Positives = 142/291 (48%), Gaps = 38/291 (13%)

Query: 1489 PGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYW--INVVFIIL 1546
            P N+ +     ++T++ FD  ++V I LN VT+ +E+       TE ++    N +F  +
Sbjct: 1279 PQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAI 1338

Query: 1547 FTGECVLKLISL-----RHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVI 1601
            F  E ++K+++L      H Y    WN+ D ++V++S+V + +A           + RV+
Sbjct: 1339 FVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVL 1398

Query: 1602 RLARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM----SNFAY 1657
            RL R  R LR++  A G++ ++  L+ SL  + NI L+      I+ I G+      F Y
Sbjct: 1399 RLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYY 1458

Query: 1658 VKKED----------------GINDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKP 1701
             +  D                 +   +NF+  G +++ LF +++  GW  ++   L++  
Sbjct: 1459 CEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVG 1518

Query: 1702 PDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENF 1752
             D  P + H          NP + + YF+S+++I    V+NM++ V++ENF
Sbjct: 1519 VDQQPVQNH----------NPWM-LLYFISFLLIVSFFVLNMFVGVVVENF 1558



 Score =  103 bits (256), Expect = 2e-21
 Identities = 75/289 (25%), Positives = 140/289 (48%), Gaps = 43/289 (14%)

Query: 1164 GKIWWNIRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFT 1223
            G++W        +IV+  +F   I++ IL+++ ++  E  Y E+ + +   LE ++ +FT
Sbjct: 776  GRLWVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVE--YHEQPEELTNALEISNIVFT 833

Query: 1224 YIFILEMLLKWIAYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRA 1283
             +F LEMLLK +A G   Y  N +   D +IV +S+  +V    G +D G +  LRT R 
Sbjct: 834  SMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIV----GQAD-GGLSVLRTFRL 888

Query: 1284 LRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTT 1343
            LR L+ +     +R  +  L+  + ++     + ++F  IFSI+G++LF  KF    +T 
Sbjct: 889  LRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTG 948

Query: 1344 DGSRFPASQVPNRSECFALMNVSQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYA 1403
            D        VP+R                    NFD++    +++ Q+ T + W +++Y 
Sbjct: 949  D-------TVPDRK-------------------NFDSLLWAIVTVFQILTQEDWNVVLYN 982

Query: 1404 AVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQ 1452
             + S           S +  +YFV  + FG++   NL + ++++ F  +
Sbjct: 983  GMAST----------SSWAALYFVALMTFGNYVLFNLLVAILVEGFQAE 1021



 Score = 92.8 bits (229), Expect = 3e-18
 Identities = 80/345 (23%), Positives = 144/345 (41%), Gaps = 92/345 (26%)

Query: 112  FSPLRRISIKILVHSLFSMLIMCTILTNCIFMTMN--NPP----DWTKNVEYTFTGIYTF 165
            +SP RR    +       + I   I  N I M+M   N P    +  K   Y FT ++ F
Sbjct: 1603 YSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVF 1662

Query: 166  ESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAY----LTEF-------VNLGNVSALR 214
            E+ +K++A GF      F +D WN LD  +++ +     L E        +N   +  +R
Sbjct: 1663 EAALKLVAFGF----RRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMR 1718

Query: 215  TFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHK 274
              R+ R LK + +  G++ ++  ++Q++ ++ ++ +L +    ++A +G++LF G L   
Sbjct: 1719 VLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF-GRL--- 1774

Query: 275  CFRNSLENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIG 334
                                                            +C E   C  + 
Sbjct: 1775 ------------------------------------------------ECSEDNPCEGLS 1786

Query: 335  RNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGK------TYM-----IFFV 383
            R     + +F  F  AFL LFR+ T D W  + + TLR   +      +Y+     ++FV
Sbjct: 1787 R-----HATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFV 1841

Query: 384  VVIFLGSFYLINLILAVVAMAYEEQNQANIEEAK---QKELEFQQ 425
              + +  F L+N+++AV+    EE N+   E+A+   + ELE  Q
Sbjct: 1842 TFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAELDAEIELEMAQ 1886



 Score = 90.1 bits (222), Expect = 2e-17
 Identities = 75/283 (26%), Positives = 129/283 (45%), Gaps = 41/283 (14%)

Query: 1500 LVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTGECVLKLISLR 1559
            +V ++ F   IM+ I +N ++M VE   Q + +T  L   N+VF  +F  E +LKL++  
Sbjct: 789  IVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACG 848

Query: 1560 HY-YFTVGWNIFDFVVVIIS---IVGMFLADLIETYFVSPTLFRVIRLARIGRILRLVKG 1615
               Y    +NIFD ++V+IS   IVG     L            V+R  R+ R+L+LV+ 
Sbjct: 849  PLGYIRNPYNIFDGIIVVISVWEIVGQADGGL-----------SVLRTFRLLRVLKLVRF 897

Query: 1616 AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA---YVKKEDG--INDMFNF 1670
               +R  L  L+ ++  +     LL L +FI++I GM  F     +K + G  + D  NF
Sbjct: 898  LPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNF 957

Query: 1671 ETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFV 1730
            ++   +++ +FQI T   W+ +L                       G     S    YFV
Sbjct: 958  DSLLWAIVTVFQILTQEDWNVVL---------------------YNGMASTSSWAALYFV 996

Query: 1731 SYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYE 1773
            + +     V+ N+ +A+++E F    + +     ED   + +E
Sbjct: 997  ALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTDEDKTSVHFE 1039



 Score = 65.5 bits (158), Expect = 5e-10
 Identities = 44/157 (28%), Positives = 80/157 (50%), Gaps = 8/157 (5%)

Query: 729 IVMDPFVDLAITICIVLNTLFMAM----EHHPMTEEFKNVLAIGNLVFTGIFAAEMVLKL 784
           +V +P+ +    + I+LN + + M    E      E  N+L   +      FA EMV+K+
Sbjct: 96  LVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKM 155

Query: 785 IAMDPYE---YFQVGWNIFDSLIVTLSLVELFLADVE-GLSVLRSFRLLRVFKLAKSWPT 840
           +A+  +    Y    WN  D  IV   ++E  L      LS +R+ R+LR  +     P+
Sbjct: 156 VALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLRPLRAINRVPS 215

Query: 841 LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 877
           + +L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 216 MRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 252



 Score = 55.8 bits (133), Expect = 4e-07
 Identities = 47/165 (28%), Positives = 77/165 (46%), Gaps = 15/165 (9%)

Query: 1500 LVTNQAFDISIMVLICLNMVTMMVEKEGQS----QHMTEVLYWINVVFIILFTGECVLKL 1555
            LV N  F+   M++I LN VT+ + +  +          +L   +      F  E V+K+
Sbjct: 96   LVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKM 155

Query: 1556 ISLRHY----YFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRLARIGRILR 1611
            ++L  +    Y    WN  DF +V+  ++   L    + + VS      IR  R+ R LR
Sbjct: 156  VALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSL----DGHNVS---LSAIRTVRVLRPLR 208

Query: 1612 LVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA 1656
             +     +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 209  AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 253



 Score = 35.8 bits (81), Expect = 0.43
 Identities = 20/101 (19%), Positives = 41/101 (40%), Gaps = 21/101 (20%)

Query: 1665 NDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSV 1724
            N   NF+  G + I +FQ+ T  GW  ++  ++++                     +   
Sbjct: 356  NGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDA---------------------HSFY 394

Query: 1725 GIFYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSE 1765
               YF+  II+    ++N+ + VI   FS   +  ++ + E
Sbjct: 395  NFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMRE 435


>gi|193788532 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 11 [Homo sapiens]
          Length = 2146

 Score =  337 bits (863), Expect = 9e-92
 Identities = 259/885 (29%), Positives = 442/885 (49%), Gaps = 72/885 (8%)

Query: 1024 ENYISNHTLAEMSKGHNFLKEKDKISGFGSSVDKHLMEDSDGQSFIHNPSLTVTVPIAPG 1083
            +N     +L    K     KE+ K++   S   K        Q  +  P++        G
Sbjct: 754  DNLADAESLTSAQKEEEEEKERKKLARTASPEKK--------QELVEKPAV--------G 797

Query: 1084 ESDLENMNAEELSSDSDSE-YSKVRLNRSSSSECSTVDNPLPGE---GEEAEAEPMNSDE 1139
            ES  E +  + +++D +S   +K+ ++    +E +   +P P     GEE E EP     
Sbjct: 798  ESKEEKIELKSITADGESPPATKINMDDLQPNE-NEDKSPYPNPETTGEEDEEEPEMPVG 856

Query: 1140 P------EACFTDGCVRRFSCCQVNIESGKGKIWWNIRKTCYKIVEHSWFESFIVLMILL 1193
            P      E    +  V         I S   +     R  C++IV  + F + I+  ILL
Sbjct: 857  PRPRPLSELHLKEKAVPMPEASAFFIFSSNNRF----RLQCHRIVNDTIFTNLILFFILL 912

Query: 1194 SSGALAFEDIYIERKKTIKIILEYADKIFTYIFILEMLLKWIAYGY----KTYFTNAWCW 1249
            SS +LA ED  ++       IL Y D +FT IF +E+ LK  AYG      ++  N +  
Sbjct: 913  SSISLAAEDP-VQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNI 971

Query: 1250 LDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPS 1309
            LD L+V VSL++    +   S +  +K LR LR LRPLRA++R +G++ VV  +  AI +
Sbjct: 972  LDLLVVSVSLISFGIQS---SAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRT 1028

Query: 1310 IMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDGSRFPASQVPNRSECFALMNVSQNV 1369
            I N+++V  +   +F+ +GV LF GK Y C   +D S+   ++       +    V   +
Sbjct: 1029 IGNIVIVTTLLQFMFACIGVQLFKGKLYTC---SDSSKQTEAECKGNYITYKDGEVDHPI 1085

Query: 1370 ----RWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIY 1425
                 W+N K +FDNV    ++L  V+TF+GW  ++Y ++DS   DK P Y Y + + I+
Sbjct: 1086 IQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIF 1145

Query: 1426 FVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKP-QK 1484
            F+++II  +FF +N+F+G +I  F +Q    G Q+    E  K     ++     +P ++
Sbjct: 1146 FIIYIIIIAFFMMNIFVGFVIVTFQEQ----GEQEYKNCELDKNQRQCVEYALKARPLRR 1201

Query: 1485 PIPRPGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFI 1544
             IP+  N+ Q  ++ +V +  F+  + VLI LN + + ++  GQS      +  +N++F 
Sbjct: 1202 YIPK--NQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFT 1259

Query: 1545 ILFTGECVLKLISLR-HYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRL 1603
             LFT E +LKLI+ +  +YF   WN FD ++V+ SIV + + ++      S       RL
Sbjct: 1260 GLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRL 1319

Query: 1604 ARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKED- 1662
             R+ R+++L+   +GIRTLL+  + S  AL  + LL+ ++ FIYA+ GM  F  +   D 
Sbjct: 1320 FRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDT 1379

Query: 1663 -GINDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGD--C 1719
              IN   NF+TF  +++ LF+  T   W  ++   +  K   C P+   P +S EG+  C
Sbjct: 1380 TEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGK--KCAPES-EPSNSTEGETPC 1436

Query: 1720 GNPSVGIFYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWEKFD 1779
            G+ S  +FYF+S+ ++   +++N+++AVI++NF   T +    L     + F  +W ++D
Sbjct: 1437 GS-SFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRD-WSILGPHHLDEFKRIWAEYD 1494

Query: 1780 PDATQFIEFSKLSDFAAALDPPLLIAK--PNKV---QLIAMDLPMVSGDRIHCLDILFAF 1834
            P+A   I+   +      + PPL   K  P++V   +L++M++P+ S   +     LFA 
Sbjct: 1495 PEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFAL 1554

Query: 1835 TK---RVLGESGEMDSLRSQ-MEERFMSANPSKVSYEPITTTLKR 1875
             +   R+  E G   S   Q  E+ F  A   + + E +   +K+
Sbjct: 1555 VRTALRIKTEEGPSPSEAHQGAEDPFRPAGNLEQANEELRAIIKK 1599



 Score =  174 bits (441), Expect = 8e-43
 Identities = 176/696 (25%), Positives = 293/696 (42%), Gaps = 132/696 (18%)

Query: 1170 IRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYI----ERKKTIKIILEYADKIFTYI 1225
            IR+ C  IVE   FE  I+L I  +  ALA   IYI    +        LE  + +F  I
Sbjct: 113  IRRACISIVEWKPFEIIILLTIFANCVALA---IYIPFPEDDSNATNSNLERVEYLFLII 169

Query: 1226 FILEMLLKWIAYGY----KTYFTNAWCWLDFLIVDVSLVTLV---------ANTLGYSDL 1272
            F +E  LK IAYG       Y  N W  LDF+IV V L + +         AN LG    
Sbjct: 170  FTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGA 229

Query: 1273 G-PIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNL 1331
            G  +K+LR  R LRPLR +S    ++VV+N++I A+  ++++ L+ L   +I++I+G+ L
Sbjct: 230  GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLEL 289

Query: 1332 FAGKFYE-CINTTDGSRFPASQVPNRSECFALMNVSQNVR--------WKNLK---VNFD 1379
            F GK ++ C N    +  PA   P  S C       +  +        W   K    NFD
Sbjct: 290  FMGKMHKTCYNQEGIADVPAEDDP--SPCALETGHGRQCQNGTVCKPGWDGPKHGITNFD 347

Query: 1380 NVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLN 1439
            N     L++ Q  T +GWT ++Y   D+V  D         + +IYFV  II GSFF LN
Sbjct: 348  NFAFAMLTVFQCITMEGWTDVLYWVNDAVGRD---------WPWIYFVTLIIIGSFFVLN 398

Query: 1440 LFIGVIIDNFNQQKKKLGGQ-DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKIQGCIF 1498
            L +GV+   F+++++K   + D     E+++    +K       Q     P N+ +G   
Sbjct: 399  LVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDE 458

Query: 1499 DLVTNQAFDISIMVLI--------------CLNMVTMMVEKEGQSQH------------- 1531
            +   N +   S    +              C   +   + K   S++             
Sbjct: 459  EKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCR 518

Query: 1532 ---MTEVLYWINVVFIILFTGECVLKLISLRHYYFTVGWNIFDFVVVIISIVGMFLADL- 1587
                + V YW+ +  + L T      L     +Y    W          +++ +F A++ 
Sbjct: 519  AAVKSNVFYWLVIFLVFLNT------LTIASEHYNQPNWLTEVQDTANKALLALFTAEML 572

Query: 1588 -------IETYFVS--------------------------PTLFRVIRLARIGRILRLVK 1614
                   ++ YFVS                          P    V+R  R+ RI ++ +
Sbjct: 573  LKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITR 632

Query: 1615 GAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEDGIND-MFNFETF 1673
                +  L+ +L+ S+ ++ ++ LLLFL + I+++ GM  F      D +      F+ F
Sbjct: 633  YWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNF 692

Query: 1674 GNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYI 1733
              S++ +FQI T   W+ ++           D    + G S  G      +   YF+   
Sbjct: 693  PQSLLTVFQILTGEDWNSVM----------YDGIMAYGGPSFPG-----MLVCIYFIILF 737

Query: 1734 IISFLVVVNMYIAVILENFSVATEESTEPLSEDDFE 1769
            I    +++N+++A+ ++N + A E  T    E++ E
Sbjct: 738  ICGNYILLNVFLAIAVDNLADA-ESLTSAQKEEEEE 772



 Score =  160 bits (404), Expect = 2e-38
 Identities = 106/355 (29%), Positives = 180/355 (50%), Gaps = 50/355 (14%)

Query: 105 ALYMLSPFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTMNNP-PDWTKN--------V 155
           AL  L+  +P+RR  I I+    F ++I+ TI  NC+ + +  P P+   N        V
Sbjct: 103 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 162

Query: 156 EYTFTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVN--------- 206
           EY F  I+T E+ +K++A G       +LR+ WN LDF+++V    +  +          
Sbjct: 163 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 222

Query: 207 -LG------NVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVF 259
            LG      +V ALR FRVLR L+ +S +P L+ ++ ++I+++  L  + +L +F + ++
Sbjct: 223 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282

Query: 260 ALIGLQLFMGNLKHKCFRNSLENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFST 319
           A+IGL+LFMG +   C+     N E +  +                     D   C   T
Sbjct: 283 AIIGLELFMGKMHKTCY-----NQEGIADV-----------------PAEDDPSPCALET 320

Query: 320 DSG-QCPEGYTCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKTY 378
             G QC  G  C      P +G T+FD F++A L +F+ +T + W ++      A G+ +
Sbjct: 321 GHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDW 380

Query: 379 -MIFFVVVIFLGSFYLINLILAVVAMAY-EEQNQANIEEAKQKELEFQQMLDRLK 431
             I+FV +I +GSF+++NL+L V++  + +E+ +A      QK  E QQ+ + LK
Sbjct: 381 PWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLK 435



 Score =  130 bits (328), Expect = 1e-29
 Identities = 100/324 (30%), Positives = 168/324 (51%), Gaps = 30/324 (9%)

Query: 705  RFAHKFLIWNCSPYWIKF-----KKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTE 759
            R AH+      S YW ++     +KC   +  + F  L I + + LNTL +A EH+    
Sbjct: 492  RLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFL-VFLNTLTIASEHYNQPN 550

Query: 760  EFKNVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADVE- 818
                V    N     +F AEM+LK+ ++    YF   +N FD  +V   ++E  L + + 
Sbjct: 551  WLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKI 610

Query: 819  ----GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGM 874
                G+SVLR  RLLR+FK+ + W +L+ L+  + NSV ++ +L L+L + + IF+++GM
Sbjct: 611  MSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGM 670

Query: 875  QLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAG---- 929
            QLFG  +        D+    R   ++F  S L VF++L GE W   M+D +   G    
Sbjct: 671  QLFGGKFN------FDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSF 724

Query: 930  QAMCLIVYMMVMVI-GNLVVLNLFLALLLSSFS-SDNLTAI--EEDPDANNLQIAVTRIK 985
              M + +Y +++ I GN ++LN+FLA+ + + + +++LT+   EE+ +    ++A T   
Sbjct: 725  PGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASP 784

Query: 986  KGINYVKQTLREFILKAFSKKPKI 1009
            +     KQ L E      SK+ KI
Sbjct: 785  E----KKQELVEKPAVGESKEEKI 804



 Score =  123 bits (309), Expect = 2e-27
 Identities = 78/266 (29%), Positives = 139/266 (52%), Gaps = 40/266 (15%)

Query: 726  IYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAIGNLVFTGIFAAEMVLKLI 785
            ++++V   + +  + + I+LNT+ +AM+H+  +  FK  + I N++FTG+F  EM+LKLI
Sbjct: 1212 VWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLI 1271

Query: 786  AMDPYEYFQVGWNIFDSLIVTLSLVELFLADVE--------GLSVLRSFRLLRVFKLAKS 837
            A  P  YF   WN FD+LIV  S+V++ + +V          ++  R FR++R+ KL   
Sbjct: 1272 AFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLVKLLSR 1331

Query: 838  WPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRW 897
               +  L+     S  AL  + L++ ++ FI+AV+GMQ+FGK        +ND   + R 
Sbjct: 1332 GEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGK------IALNDTTEINR- 1384

Query: 898  HMNDFFHSF----LIVFRVLCGE-WIETMWDCM------------------EVAGQAMCL 934
              N+ F +F    L++FR   GE W + M  CM                     G +  +
Sbjct: 1385 --NNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAV 1442

Query: 935  IVYMMVMVIGNLVVLNLFLALLLSSF 960
              ++   ++   +++NLF+A+++ +F
Sbjct: 1443 FYFISFYMLCAFLIINLFVAVIMDNF 1468



 Score =  102 bits (253), Expect = 5e-21
 Identities = 79/325 (24%), Positives = 148/325 (45%), Gaps = 42/325 (12%)

Query: 1168 WN--IRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYI 1225
            WN   R+ C   V+ + F   ++ ++ L++  +A E  +  +   +  + + A+K    +
Sbjct: 509  WNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASE--HYNQPNWLTEVQDTANKALLAL 566

Query: 1226 FILEMLLKWIAYGYKTYFTNAWCWLD-FLIVDVSLVTLVANTLGYSDLGPIKSLRTLRAL 1284
            F  EMLLK  + G + YF + +   D F++    L T++  T   S LG I  LR +R L
Sbjct: 567  FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLG-ISVLRCVRLL 625

Query: 1285 RPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTD 1344
            R  +    +  +  +V +L+ ++ SI ++LL+  +F +IFS++G+ LF GKF        
Sbjct: 626  RIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF-------- 677

Query: 1345 GSRFPASQVPNRSECFALMNVSQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAA 1404
                      N  E             +  +  FDN     L++ Q+ T + W  +MY  
Sbjct: 678  ----------NFDEM------------QTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDG 715

Query: 1405 VDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMT 1464
            + +      P     + + IYF++  I G++  LN+F+ + +DN    +     Q     
Sbjct: 716  IMAYGGPSFP----GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQK--EE 769

Query: 1465 EEQKKYYNAMKKLGSKKPQKPIPRP 1489
            EE+K+     +    +K Q+ + +P
Sbjct: 770  EEEKERKKLARTASPEKKQELVEKP 794



 Score = 92.4 bits (228), Expect = 4e-18
 Identities = 94/407 (23%), Positives = 177/407 (43%), Gaps = 70/407 (17%)

Query: 39   KKDDDEEAPKPSSDLEAGKQLPFIYGDIPPGMVSEPLEDLDPYYADKKTFIVLNKGKTIF 98
            + +D    P P +  E  ++ P    ++P G    PL +L      K+  + + +    F
Sbjct: 830  ENEDKSPYPNPETTGEEDEEEP----EMPVGPRPRPLSELHL----KEKAVPMPEASAFF 881

Query: 99   RFNATPALYMLSPFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTMNNPPDWTK----- 153
             F++          +  R    +I+  ++F+ LI+  IL + I +   +P   T      
Sbjct: 882  IFSSN---------NRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHI 932

Query: 154  --NVEYTFTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVN---LG 208
                +  FT I+T E  +K+ A G  + + +F R+ +N LD +V+  + ++  +    + 
Sbjct: 933  LFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAIN 992

Query: 209  NVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFM 268
             V  LR  RVLR L+ I+   GLK +V  +  +++ + +++I+T     +FA IG+QLF 
Sbjct: 993  VVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFK 1052

Query: 269  GNLKHKCFRNSLENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGY 328
            G L + C  +S +     +              Y  Y +G  D  +          P  +
Sbjct: 1053 GKL-YTCSDSSKQTEAECKG------------NYITYKDGEVDHPIIQ--------PRSW 1091

Query: 329  TCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRA----AGKTY------ 378
               K           FD    A +ALF + T + W  L  +++ +     G  Y      
Sbjct: 1092 ENSKF---------DFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEI 1142

Query: 379  MIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANIEEAKQKELEFQQ 425
             IFF++ I + +F+++N+ +  V + ++EQ +   +E K  EL+  Q
Sbjct: 1143 SIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGE---QEYKNCELDKNQ 1186



 Score = 86.3 bits (212), Expect = 3e-16
 Identities = 95/353 (26%), Positives = 151/353 (42%), Gaps = 48/353 (13%)

Query: 1464 TEEQKKYYNAMKKLGSKKPQKPIPRP------GNKIQGCIFDLVTNQAFDISIMVLICLN 1517
            T+ +++ Y   KK GS    +P PR        N I+     +V  + F+I I++ I  N
Sbjct: 79   TQRKRQQYGKPKKQGSTTATRP-PRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFAN 137

Query: 1518 MVTMMVE---KEGQSQHMTEVLYWINVVFIILFTGECVLKLISLR-----HYYFTVGWNI 1569
             V + +     E  S      L  +  +F+I+FT E  LK+I+       + Y   GWN+
Sbjct: 138  CVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNL 197

Query: 1570 FDFVVVIISIVGMFL-----ADLIETYFVSPTLFRV--IRLARIGRILRLVKGAKGIRTL 1622
             DF++V++ +    L     AD           F V  +R  R+ R LRLV G   ++ +
Sbjct: 198  LDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVV 257

Query: 1623 LFALMMSLPALFNIGLLLFLVMFIYAIFGMSNF-----AYVKKEDGINDM--------FN 1669
            L +++ ++  L +I LL+  V+ IYAI G+  F          ++GI D+          
Sbjct: 258  LNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCA 317

Query: 1670 FETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCG-----NPSV 1724
             ET G+   C        GWDG    I N          V    ++EG        N +V
Sbjct: 318  LET-GHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAV 376

Query: 1725 G----IFYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYE 1773
            G      YFV+ III    V+N+ + V+   FS   +E  +  +  DF+   E
Sbjct: 377  GRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFS---KEREKAKARGDFQKLRE 426



 Score = 84.0 bits (206), Expect = 1e-15
 Identities = 75/299 (25%), Positives = 132/299 (44%), Gaps = 60/299 (20%)

Query: 723 KKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNV----LAIGNLVFTGIFAA 778
           + CI  +   PF ++ I + I  N + +A+ + P  E+  N     L     +F  IF  
Sbjct: 115 RACISIVEWKPF-EIIILLTIFANCVALAI-YIPFPEDDSNATNSNLERVEYLFLIIFTV 172

Query: 779 EMVLKLIA----MDPYEYFQVGWNIFDSLIVTLSLVELFLADVE---------------G 819
           E  LK+IA      P  Y + GWN+ D +IV + L    L                    
Sbjct: 173 EAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFD 232

Query: 820 LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-G 878
           +  LR+FR+LR  +L    P+L +++  I  ++  L ++ L++  ++ I+A++G++LF G
Sbjct: 233 VKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMG 292

Query: 879 KSYKECV-------CKINDD---CTL---------------PRW--------HMNDFFHS 905
           K +K C            DD   C L               P W        + ++F  +
Sbjct: 293 KMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFA 352

Query: 906 FLIVFRVLCGE-WIETMWDCMEVAGQAMCLIVYMMVMVIGNLVVLNLFLALLLSSFSSD 963
            L VF+ +  E W + ++   +  G+    I ++ +++IG+  VLNL L +L   FS +
Sbjct: 353 MLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKE 411



 Score = 68.2 bits (165), Expect = 8e-11
 Identities = 47/169 (27%), Positives = 89/169 (52%), Gaps = 8/169 (4%)

Query: 721  KFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKN-VLAIGNLVFTGIFAAE 779
            +F+   + IV D      I   I+L+++ +A E       F+N +L   ++VFT IF  E
Sbjct: 888  RFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIE 947

Query: 780  MVLKLIAMDPY----EYFQVGWNIFDSLIVTLSLVELFLAD--VEGLSVLRSFRLLRVFK 833
            + LK+ A   +     + +  +NI D L+V++SL+   +    +  + +LR  R+LR  +
Sbjct: 948  IALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLR 1007

Query: 834  LAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSY 881
                   L  +++ +  ++  +GN+ +V  ++ F+FA +G+QLF GK Y
Sbjct: 1008 AINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLY 1056



 Score = 62.4 bits (150), Expect = 4e-09
 Identities = 80/383 (20%), Positives = 148/383 (38%), Gaps = 75/383 (19%)

Query: 126 SLFSMLIMCTILTNCIFMTMN--NPPDWTKNVEYT----FTGIYTFESLVKILARGFCVG 179
           ++F  L++  +  N + +     N P+W   V+ T       ++T E L+K+    + +G
Sbjct: 524 NVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKM----YSLG 579

Query: 180 EFTFLRDPWNWLDFVVIVFAYL------TEFVNLGNVSALRTFRVLRALKTISVIPGLKT 233
              +    +N  D  V+    L      T+ ++   +S LR  R+LR  K       L  
Sbjct: 580 LQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSN 639

Query: 234 IVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETLESIMNTL 293
           +V +L+ SV+ ++ +++L    + +F+L+G+QLF G            N + +++  +T 
Sbjct: 640 LVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF----------NFDEMQTRRSTF 689

Query: 294 ESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLA 353
           ++                +LL  F   +G   E +  V       YG  SF         
Sbjct: 690 DN-------------FPQSLLTVFQILTG---EDWNSVMYDGIMAYGGPSF--------- 724

Query: 354 LFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVA---MAYEEQNQ 410
                                G    I+F+++   G++ L+N+ LA+        E    
Sbjct: 725 --------------------PGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTS 764

Query: 411 ANIEEAKQKELEFQQMLDRLKKEQEEAEAIAAAAAEYTSIRRSRIMGLSESSSETSKLSS 470
           A  EE ++KE +        +K+QE  E  A   ++   I    I    ES   T K++ 
Sbjct: 765 AQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPAT-KINM 823

Query: 471 KSAKERRNRRKKKNQKKLSSGEE 493
              +   N  K       ++GEE
Sbjct: 824 DDLQPNENEDKSPYPNPETTGEE 846



 Score = 57.8 bits (138), Expect = 1e-07
 Identities = 62/275 (22%), Positives = 109/275 (39%), Gaps = 100/275 (36%)

Query: 159  FTGIYTFESLVKILA----RGFCVGEFTFLRDPWNWLDFVVIVFAY----LTEFVNLG-- 208
            FTG++T E ++K++A      FC        D WN  D +++V +     +TE  N    
Sbjct: 1258 FTGLFTVEMILKLIAFKPKHYFC--------DAWNTFDALIVVGSIVDIAITEVNNAEEN 1309

Query: 209  ---NVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQ 265
               +++  R FRV+R +K +S   G++T++   I+S + L  V +L V    ++A+IG+Q
Sbjct: 1310 SRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQ 1369

Query: 266  LFMGNLKHKCFRNSLENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCP 325
            +F            +  N+T E                                      
Sbjct: 1370 VF----------GKIALNDTTE-------------------------------------- 1381

Query: 326  EGYTCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTL-------------- 371
                   I RN      +F TF  A L LFR  T + W+++    +              
Sbjct: 1382 -------INRN-----NNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNS 1429

Query: 372  ----RAAGKTYMIFFVVVIF-LGSFYLINLILAVV 401
                   G ++ +F+ +  + L +F +INL +AV+
Sbjct: 1430 TEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVI 1464


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.137    0.407 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 70,264,342
Number of Sequences: 37866
Number of extensions: 3114334
Number of successful extensions: 22003
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 156
Number of HSP's successfully gapped in prelim test: 308
Number of HSP's that attempted gapping in prelim test: 15506
Number of HSP's gapped (non-prelim): 3631
length of query: 1977
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1860
effective length of database: 13,817,196
effective search space: 25699984560
effective search space used: 25699984560
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 70 (31.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.