Search of human proteins with 4506775

Search of human proteins with 4506775

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4506775 membrane-bound transcription factor site-1 protease
preproprotein [Homo sapiens]
         (1052 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4506775 membrane-bound transcription factor site-1 protease p...  2168   0.0  
gi|186972143 tripeptidyl peptidase II [Homo sapiens]                   67   1e-10
gi|31317307 proprotein convertase subtilisin/kexin type 9 prepro...    39   0.034
gi|20336242 proprotein convertase subtilisin/kexin type 1 prepro...    38   0.044
gi|20336188 paired basic amino acid cleaving system 4 isoform e ...    37   0.13 
gi|20336186 paired basic amino acid cleaving system 4 isoform c ...    37   0.13 
gi|27894285 paired basic amino acid cleaving system 4 isoform f ...    37   0.13 
gi|20336190 paired basic amino acid cleaving system 4 isoform d ...    37   0.13 
gi|20336184 paired basic amino acid cleaving system 4 isoform h ...    37   0.13 
gi|20336182 paired basic amino acid cleaving system 4 isoform g ...    37   0.13 
gi|4505577 paired basic amino acid cleaving system 4 isoform a p...    37   0.13 
gi|20336180 paired basic amino acid cleaving system 4 isoform b ...    37   0.13 
gi|20336244 proprotein convertase subtilisin/kexin type 2 [Homo ...    36   0.17 
gi|20336248 proprotein convertase subtilisin/kexin type 7 prepro...    34   0.63 
gi|5902808 bone morphogenetic protein 1 isoform 2 precursor [Hom...    34   0.83 
gi|170784869 tetratricopeptide repeat domain 13 isoform b [Homo ...    34   0.83 
gi|170784867 tetratricopeptide repeat domain 13 isoform a [Homo ...    34   0.83 
gi|20336246 proprotein convertase subtilisin/kexin type 5 prepro...    33   1.4  
gi|11034849 ectonucleotide pyrophosphatase/phosphodiesterase 5 (...    32   2.4  
gi|115298654 mutY homolog isoform 4 [Homo sapiens]                     32   3.1  
gi|115298652 mutY homolog isoform 4 [Homo sapiens]                     32   3.1  
gi|115298650 mutY homolog isoform 3 [Homo sapiens]                     32   3.1  
gi|115298648 mutY homolog isoform 2 [Homo sapiens]                     32   3.1  
gi|6912520 mutY homolog isoform 1 [Homo sapiens]                       32   3.1  
gi|190358497 mutY homolog isoform 5 [Homo sapiens]                     32   3.1  
gi|4505579 furin preproprotein [Homo sapiens]                          32   3.1  
gi|58331242 formin homology 2 domain containing 3 [Homo sapiens]       32   3.1  
gi|27262667 colony stimulating factor 1 isoform a precursor [Hom...    31   7.0  
gi|27262661 colony stimulating factor 1 isoform a precursor [Hom...    31   7.0  
gi|91718902 myeloid/lymphoid or mixed-lineage leukemia 3 [Homo s...    31   7.0  

>gi|4506775 membrane-bound transcription factor site-1 protease
            preproprotein [Homo sapiens]
          Length = 1052

 Score = 2168 bits (5617), Expect = 0.0
 Identities = 1052/1052 (100%), Positives = 1052/1052 (100%)

Query: 1    MKLVNIWLLLLVVLLCGKKHLGDRLEKKSFEKAPCPGCSHLTLKVEFSSTVVEYEYIVAF 60
            MKLVNIWLLLLVVLLCGKKHLGDRLEKKSFEKAPCPGCSHLTLKVEFSSTVVEYEYIVAF
Sbjct: 1    MKLVNIWLLLLVVLLCGKKHLGDRLEKKSFEKAPCPGCSHLTLKVEFSSTVVEYEYIVAF 60

Query: 61   NGYFTAKARNSFISSALKSSEVDNWRIIPRNNPSSDYPSDFEVIQIKEKQKAGLLTLEDH 120
            NGYFTAKARNSFISSALKSSEVDNWRIIPRNNPSSDYPSDFEVIQIKEKQKAGLLTLEDH
Sbjct: 61   NGYFTAKARNSFISSALKSSEVDNWRIIPRNNPSSDYPSDFEVIQIKEKQKAGLLTLEDH 120

Query: 121  PNIKRVTPQRKVFRSLKYAESDPTVPCNETRWSQKWQSSRPLRRASLSLGSGFWHATGRH 180
            PNIKRVTPQRKVFRSLKYAESDPTVPCNETRWSQKWQSSRPLRRASLSLGSGFWHATGRH
Sbjct: 121  PNIKRVTPQRKVFRSLKYAESDPTVPCNETRWSQKWQSSRPLRRASLSLGSGFWHATGRH 180

Query: 181  SSRRLLRAIPRQVAQTLQADVLWQMGYTGANVRVAVFDTGLSEKHPHFKNVKERTNWTNE 240
            SSRRLLRAIPRQVAQTLQADVLWQMGYTGANVRVAVFDTGLSEKHPHFKNVKERTNWTNE
Sbjct: 181  SSRRLLRAIPRQVAQTLQADVLWQMGYTGANVRVAVFDTGLSEKHPHFKNVKERTNWTNE 240

Query: 241  RTLDDGLGHGTFVAGVIASMRECQGFAPDAELHIFRVFTNNQVSYTSWFLDAFNYAILKK 300
            RTLDDGLGHGTFVAGVIASMRECQGFAPDAELHIFRVFTNNQVSYTSWFLDAFNYAILKK
Sbjct: 241  RTLDDGLGHGTFVAGVIASMRECQGFAPDAELHIFRVFTNNQVSYTSWFLDAFNYAILKK 300

Query: 301  IDVLNLSIGGPDFMDHPFVDKVWELTANNVIMVSAIGNDGPLYGTLNNPADQMDVIGVGG 360
            IDVLNLSIGGPDFMDHPFVDKVWELTANNVIMVSAIGNDGPLYGTLNNPADQMDVIGVGG
Sbjct: 301  IDVLNLSIGGPDFMDHPFVDKVWELTANNVIMVSAIGNDGPLYGTLNNPADQMDVIGVGG 360

Query: 361  IDFEDNIARFSSRGMTTWELPGGYGRMKPDIVTYGAGVRGSGVKGGCRALSGTSVASPVV 420
            IDFEDNIARFSSRGMTTWELPGGYGRMKPDIVTYGAGVRGSGVKGGCRALSGTSVASPVV
Sbjct: 361  IDFEDNIARFSSRGMTTWELPGGYGRMKPDIVTYGAGVRGSGVKGGCRALSGTSVASPVV 420

Query: 421  AGAVTLLVSTVQKRELVNPASMKQALIASARRLPGVNMFEQGHGKLDLLRAYQILNSYKP 480
            AGAVTLLVSTVQKRELVNPASMKQALIASARRLPGVNMFEQGHGKLDLLRAYQILNSYKP
Sbjct: 421  AGAVTLLVSTVQKRELVNPASMKQALIASARRLPGVNMFEQGHGKLDLLRAYQILNSYKP 480

Query: 481  QASLSPSYIDLTECPYMWPYCSQPIYYGGMPTVVNVTILNGMGVTGRIVDKPDWQPYLPQ 540
            QASLSPSYIDLTECPYMWPYCSQPIYYGGMPTVVNVTILNGMGVTGRIVDKPDWQPYLPQ
Sbjct: 481  QASLSPSYIDLTECPYMWPYCSQPIYYGGMPTVVNVTILNGMGVTGRIVDKPDWQPYLPQ 540

Query: 541  NGDNIEVAFSYSSVLWPWSGYLAISISVTKKAASWEGIAQGHVMITVASPAETESKNGAE 600
            NGDNIEVAFSYSSVLWPWSGYLAISISVTKKAASWEGIAQGHVMITVASPAETESKNGAE
Sbjct: 541  NGDNIEVAFSYSSVLWPWSGYLAISISVTKKAASWEGIAQGHVMITVASPAETESKNGAE 600

Query: 601  QTSTVKLPIKVKIIPTPPRSKRVLWDQYHNLRYPPGYFPRDNLRMKNDPLDWNGDHIHTN 660
            QTSTVKLPIKVKIIPTPPRSKRVLWDQYHNLRYPPGYFPRDNLRMKNDPLDWNGDHIHTN
Sbjct: 601  QTSTVKLPIKVKIIPTPPRSKRVLWDQYHNLRYPPGYFPRDNLRMKNDPLDWNGDHIHTN 660

Query: 661  FRDMYQHLRSMGYFVEVLGAPFTCFDASQYGTLLMVDSEEEYFPEEIAKLRRDVDNGLSL 720
            FRDMYQHLRSMGYFVEVLGAPFTCFDASQYGTLLMVDSEEEYFPEEIAKLRRDVDNGLSL
Sbjct: 661  FRDMYQHLRSMGYFVEVLGAPFTCFDASQYGTLLMVDSEEEYFPEEIAKLRRDVDNGLSL 720

Query: 721  VIFSDWYNTSVMRKVKFYDENTRQWWMPDTGGANIPALNELLSVWNMGFSDGLYEGEFTL 780
            VIFSDWYNTSVMRKVKFYDENTRQWWMPDTGGANIPALNELLSVWNMGFSDGLYEGEFTL
Sbjct: 721  VIFSDWYNTSVMRKVKFYDENTRQWWMPDTGGANIPALNELLSVWNMGFSDGLYEGEFTL 780

Query: 781  ANHDMYYASGCSIAKFPEDGVVITQTFKDQGLEVLKQETAVVENVPILGLYQIPAEGGGR 840
            ANHDMYYASGCSIAKFPEDGVVITQTFKDQGLEVLKQETAVVENVPILGLYQIPAEGGGR
Sbjct: 781  ANHDMYYASGCSIAKFPEDGVVITQTFKDQGLEVLKQETAVVENVPILGLYQIPAEGGGR 840

Query: 841  IVLYGDSNCLDDSHRQKDCFWLLDALLQYTSYGVTPPSLSHSGNRQRPPSGAGSVTPERM 900
            IVLYGDSNCLDDSHRQKDCFWLLDALLQYTSYGVTPPSLSHSGNRQRPPSGAGSVTPERM
Sbjct: 841  IVLYGDSNCLDDSHRQKDCFWLLDALLQYTSYGVTPPSLSHSGNRQRPPSGAGSVTPERM 900

Query: 901  EGNHLHRYSKVLEAHLGDPKPRPLPACPRLSWAKPQPLNETAPSNLWKHQKLLSIDLDKV 960
            EGNHLHRYSKVLEAHLGDPKPRPLPACPRLSWAKPQPLNETAPSNLWKHQKLLSIDLDKV
Sbjct: 901  EGNHLHRYSKVLEAHLGDPKPRPLPACPRLSWAKPQPLNETAPSNLWKHQKLLSIDLDKV 960

Query: 961  VLPNFRSNRPQVRPLSPGESGAWDIPGGIMPGRYNQEVGQTIPVFAFLGAMVVLAFFVVQ 1020
            VLPNFRSNRPQVRPLSPGESGAWDIPGGIMPGRYNQEVGQTIPVFAFLGAMVVLAFFVVQ
Sbjct: 961  VLPNFRSNRPQVRPLSPGESGAWDIPGGIMPGRYNQEVGQTIPVFAFLGAMVVLAFFVVQ 1020

Query: 1021 INKAKSRPKRRKPRVKRPQLMQQVHPPKTPSV 1052
            INKAKSRPKRRKPRVKRPQLMQQVHPPKTPSV
Sbjct: 1021 INKAKSRPKRRKPRVKRPQLMQQVHPPKTPSV 1052


>gi|186972143 tripeptidyl peptidase II [Homo sapiens]
          Length = 1249

 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 67/254 (26%), Positives = 112/254 (44%), Gaps = 27/254 (10%)

Query: 246 GLGHGTFVAGVIASM----RECQGFAPDAELHIFRVFTN--NQVSYTSWFLDAFNYAILK 299
           G  HGT VA + A       E  G AP A++   ++     + +   +  + A    I  
Sbjct: 261 GGAHGTHVASIAAGHFPEEPERNGVAPGAQILSIKIGDTRLSTMETGTGLIRAMIEVINH 320

Query: 300 KIDVLNLSIGGPDFMDHP------FVDKVWELTANNVIMVSAIGNDGPLYGTLNNPADQM 353
           K D++N S G      +         + VW+   +N+I VS+ GN+GP   T+  P    
Sbjct: 321 KCDLVNYSYGEATHWPNSGRICEVINEAVWK---HNIIYVSSAGNNGPCLSTVGCPGGTT 377

Query: 354 D-VIGVGGIDFEDN-IARFSSR-----GMTTWEL--PGGYGRMKPDIVTYGAGVRG--SG 402
             VIGVG     D  +A +S R        TW    P   G +   I   G  +    + 
Sbjct: 378 SSVIGVGAYVSPDMMVAEYSLREKLPANQYTWSSRGPSADGALGVSISAPGGAIASVPNW 437

Query: 403 VKGGCRALSGTSVASPVVAGAVTLLVSTVQKREL-VNPASMKQALIASARRLPGVNMFEQ 461
              G + ++GTS++SP   G + L++S ++   +     S+++AL  +A +   + +F Q
Sbjct: 438 TLRGTQLMNGTSMSSPNACGGIALILSGLKANNIDYTVHSVRRALENTAVKADNIEVFAQ 497

Query: 462 GHGKLDLLRAYQIL 475
           GHG + + +AY  L
Sbjct: 498 GHGIIQVDKAYDYL 511


>gi|31317307 proprotein convertase subtilisin/kexin type 9
           preproprotein [Homo sapiens]
          Length = 692

 Score = 38.5 bits (88), Expect = 0.034
 Identities = 62/259 (23%), Positives = 97/259 (37%), Gaps = 39/259 (15%)

Query: 209 GANVRVAVFDTGLSEKHPH---------FKNVKERTNWTNERTLDDGLGHGTFVAGVIAS 259
           G+ V V + DT +   H           F+NV E       R       HGT +AGV++ 
Sbjct: 177 GSLVEVYLLDTSIQSDHREIEGRVMVTDFENVPEEDGTRFHRQASKCDSHGTHLAGVVSG 236

Query: 260 MRECQGFAPDAELHIFRVFTNNQVSYTSWFLDAFNY----AILKKIDVLNLSIGGPDFMD 315
                G A  A +   RV         S  L    +     +++ +  L + +       
Sbjct: 237 --RDAGVAKGASMRSLRVLNCQGKGTVSGTLIGLEFIRKSQLVQPVGPLVVLLPLAGGYS 294

Query: 316 HPFVDKVWELTANNVIMVSAIGN---DGPLYGTLNNPADQMDVIGVGGIDFEDNIARFSS 372
                    L    V++V+A GN   D  LY    +PA   +VI VG  + +D       
Sbjct: 295 RVLNAACQRLARAGVVLVTAAGNFRDDACLY----SPASAPEVITVGATNAQD------- 343

Query: 373 RGMTTWELPGGYGRMKPDIVTYGAGVRGSGVKGGCR----ALSGTSVASPVVAGAVTLLV 428
           + +T   L   +GR    +  +  G    G    C     + SGTS A+  VAG   +++
Sbjct: 344 QPVTLGTLGTNFGRC---VDLFAPGEDIIGASSDCSTCFVSQSGTSQAAAHVAGIAAMML 400

Query: 429 STVQKRELVNPASMKQALI 447
           S   +  L   A ++Q LI
Sbjct: 401 SAEPELTL---AELRQRLI 416


>gi|20336242 proprotein convertase subtilisin/kexin type 1
           preproprotein [Homo sapiens]
          Length = 753

 Score = 38.1 bits (87), Expect = 0.044
 Identities = 32/122 (26%), Positives = 48/122 (39%), Gaps = 8/122 (6%)

Query: 105 QIKEKQKAGLLTLEDHPNIKRVTPQRKVFRSLKYAESDPTVPCNETRWSQKWQSSRPLRR 164
           QI   +   L   ++HP   R    R  F   K    D  V   E ++ ++      LR 
Sbjct: 60  QIGSLENHYLFKHKNHPRRSR----RSAFHITKRLSDDDRVIWAEQQYEKERSKRSALRD 115

Query: 165 ASLSL-GSGFWHATGRHSSRRLLRAIPRQVAQTLQADVLWQMGYTGANVRVAVFDTGLSE 223
           ++L+L     W+        R+  A+P+     L    +WQ G TG  V + V D GL  
Sbjct: 116 SALNLFNDPMWNQQWYLQDTRMTAALPKL---DLHVIPVWQKGITGKGVVITVLDDGLEW 172

Query: 224 KH 225
            H
Sbjct: 173 NH 174


>gi|20336188 paired basic amino acid cleaving system 4 isoform e
           preproprotein [Homo sapiens]
          Length = 623

 Score = 36.6 bits (83), Expect = 0.13
 Identities = 26/107 (24%), Positives = 38/107 (35%), Gaps = 27/107 (25%)

Query: 121 PNIKRVTPQRKVFRSLKYAESDP-TVPCNETRWSQKWQSSRPLRRASLSLGSGFWHATGR 179
           P +K +  Q    R  +   SDP  +  N+  WS  W                + H   +
Sbjct: 133 PQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMW----------------YLHCGDK 176

Query: 180 HSSRRLLRAIPRQVAQTLQADVLWQMGYTGANVRVAVFDTGLSEKHP 226
           +S  R            +     W+ GYTG NV V + D G+   HP
Sbjct: 177 NSRCR----------SEMNVQAAWKRGYTGKNVVVTILDDGIERNHP 213


>gi|20336186 paired basic amino acid cleaving system 4 isoform c
           preproprotein [Homo sapiens]
          Length = 487

 Score = 36.6 bits (83), Expect = 0.13
 Identities = 26/107 (24%), Positives = 38/107 (35%), Gaps = 27/107 (25%)

Query: 121 PNIKRVTPQRKVFRSLKYAESDP-TVPCNETRWSQKWQSSRPLRRASLSLGSGFWHATGR 179
           P +K +  Q    R  +   SDP  +  N+  WS  W                + H   +
Sbjct: 133 PQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMW----------------YLHCGDK 176

Query: 180 HSSRRLLRAIPRQVAQTLQADVLWQMGYTGANVRVAVFDTGLSEKHP 226
           +S  R            +     W+ GYTG NV V + D G+   HP
Sbjct: 177 NSRCR----------SEMNVQAAWKRGYTGKNVVVTILDDGIERNHP 213


>gi|27894285 paired basic amino acid cleaving system 4 isoform f
           preproprotein [Homo sapiens]
          Length = 664

 Score = 36.6 bits (83), Expect = 0.13
 Identities = 26/107 (24%), Positives = 38/107 (35%), Gaps = 27/107 (25%)

Query: 121 PNIKRVTPQRKVFRSLKYAESDP-TVPCNETRWSQKWQSSRPLRRASLSLGSGFWHATGR 179
           P +K +  Q    R  +   SDP  +  N+  WS  W                + H   +
Sbjct: 133 PQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMW----------------YLHCGDK 176

Query: 180 HSSRRLLRAIPRQVAQTLQADVLWQMGYTGANVRVAVFDTGLSEKHP 226
           +S  R            +     W+ GYTG NV V + D G+   HP
Sbjct: 177 NSRCR----------SEMNVQAAWKRGYTGKNVVVTILDDGIERNHP 213


>gi|20336190 paired basic amino acid cleaving system 4 isoform d
           preproprotein [Homo sapiens]
          Length = 652

 Score = 36.6 bits (83), Expect = 0.13
 Identities = 26/107 (24%), Positives = 38/107 (35%), Gaps = 27/107 (25%)

Query: 121 PNIKRVTPQRKVFRSLKYAESDP-TVPCNETRWSQKWQSSRPLRRASLSLGSGFWHATGR 179
           P +K +  Q    R  +   SDP  +  N+  WS  W                + H   +
Sbjct: 133 PQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMW----------------YLHCGDK 176

Query: 180 HSSRRLLRAIPRQVAQTLQADVLWQMGYTGANVRVAVFDTGLSEKHP 226
           +S  R            +     W+ GYTG NV V + D G+   HP
Sbjct: 177 NSRCR----------SEMNVQAAWKRGYTGKNVVVTILDDGIERNHP 213


>gi|20336184 paired basic amino acid cleaving system 4 isoform h
           preproprotein [Homo sapiens]
          Length = 962

 Score = 36.6 bits (83), Expect = 0.13
 Identities = 26/107 (24%), Positives = 38/107 (35%), Gaps = 27/107 (25%)

Query: 121 PNIKRVTPQRKVFRSLKYAESDP-TVPCNETRWSQKWQSSRPLRRASLSLGSGFWHATGR 179
           P +K +  Q    R  +   SDP  +  N+  WS  W                + H   +
Sbjct: 133 PQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMW----------------YLHCGDK 176

Query: 180 HSSRRLLRAIPRQVAQTLQADVLWQMGYTGANVRVAVFDTGLSEKHP 226
           +S  R            +     W+ GYTG NV V + D G+   HP
Sbjct: 177 NSRCR----------SEMNVQAAWKRGYTGKNVVVTILDDGIERNHP 213


>gi|20336182 paired basic amino acid cleaving system 4 isoform g
           preproprotein [Homo sapiens]
          Length = 975

 Score = 36.6 bits (83), Expect = 0.13
 Identities = 26/107 (24%), Positives = 38/107 (35%), Gaps = 27/107 (25%)

Query: 121 PNIKRVTPQRKVFRSLKYAESDP-TVPCNETRWSQKWQSSRPLRRASLSLGSGFWHATGR 179
           P +K +  Q    R  +   SDP  +  N+  WS  W                + H   +
Sbjct: 133 PQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMW----------------YLHCGDK 176

Query: 180 HSSRRLLRAIPRQVAQTLQADVLWQMGYTGANVRVAVFDTGLSEKHP 226
           +S  R            +     W+ GYTG NV V + D G+   HP
Sbjct: 177 NSRCR----------SEMNVQAAWKRGYTGKNVVVTILDDGIERNHP 213


>gi|4505577 paired basic amino acid cleaving system 4 isoform a
           preproprotein [Homo sapiens]
          Length = 969

 Score = 36.6 bits (83), Expect = 0.13
 Identities = 26/107 (24%), Positives = 38/107 (35%), Gaps = 27/107 (25%)

Query: 121 PNIKRVTPQRKVFRSLKYAESDP-TVPCNETRWSQKWQSSRPLRRASLSLGSGFWHATGR 179
           P +K +  Q    R  +   SDP  +  N+  WS  W                + H   +
Sbjct: 133 PQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMW----------------YLHCGDK 176

Query: 180 HSSRRLLRAIPRQVAQTLQADVLWQMGYTGANVRVAVFDTGLSEKHP 226
           +S  R            +     W+ GYTG NV V + D G+   HP
Sbjct: 177 NSRCR----------SEMNVQAAWKRGYTGKNVVVTILDDGIERNHP 213


>gi|20336180 paired basic amino acid cleaving system 4 isoform b
           preproprotein [Homo sapiens]
          Length = 956

 Score = 36.6 bits (83), Expect = 0.13
 Identities = 26/107 (24%), Positives = 38/107 (35%), Gaps = 27/107 (25%)

Query: 121 PNIKRVTPQRKVFRSLKYAESDP-TVPCNETRWSQKWQSSRPLRRASLSLGSGFWHATGR 179
           P +K +  Q    R  +   SDP  +  N+  WS  W                + H   +
Sbjct: 133 PQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMW----------------YLHCGDK 176

Query: 180 HSSRRLLRAIPRQVAQTLQADVLWQMGYTGANVRVAVFDTGLSEKHP 226
           +S  R            +     W+ GYTG NV V + D G+   HP
Sbjct: 177 NSRCR----------SEMNVQAAWKRGYTGKNVVVTILDDGIERNHP 213


>gi|20336244 proprotein convertase subtilisin/kexin type 2 [Homo
           sapiens]
          Length = 638

 Score = 36.2 bits (82), Expect = 0.17
 Identities = 63/256 (24%), Positives = 101/256 (39%), Gaps = 43/256 (16%)

Query: 203 WQMGYTGANVRVAVFDTGLSEKHPHFK---NVKERTNWTNE------RTLDDGL-GHGTF 252
           W++GYTG  V + + D G+   HP      N +   ++++       R  DD    HGT 
Sbjct: 152 WELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPYPRYTDDWFNSHGTR 211

Query: 253 VAGVIASMRECQ----GFAPDAELHIFRVFTNNQVSYTSWFLDAFNYAILKK-IDVLNLS 307
            AG +++         G A ++++   R+       + +  ++A + + + + ID+ + S
Sbjct: 212 CAGEVSAAANNNICGVGVAYNSKVAGIRMLDQ---PFMTDIIEASSISHMPQLIDIYSAS 268

Query: 308 IGGPDFMDHPFVDKVWELT-------------ANNVIMVSAIGNDGPLYGTLN--NPADQ 352
            G  D  +   VD   ELT                 I V A G DG  Y   N    A  
Sbjct: 269 WGPTD--NGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASG-DGGSYDDCNCDGYASS 325

Query: 353 MDVIGVGGIDFEDNIARFSSRGMTTWELPGGYGRMK-PDIVTYGAGVRGSGVKGGCRAL- 410
           M  I +     +   A +     +T       GR + P+     AGV  + + G C    
Sbjct: 326 MWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPE-----AGVATTDLYGNCTLRH 380

Query: 411 SGTSVASPVVAGAVTL 426
           SGTS A+P  AG   L
Sbjct: 381 SGTSAAAPEAAGVFAL 396


>gi|20336248 proprotein convertase subtilisin/kexin type 7
           preproprotein [Homo sapiens]
          Length = 785

 Score = 34.3 bits (77), Expect = 0.63
 Identities = 93/399 (23%), Positives = 148/399 (37%), Gaps = 87/399 (21%)

Query: 155 KWQSS-RPLRRASLSLGSGF------WHATGRHSSRRLLRAIPRQVAQTLQADVLWQMGY 207
           +W S  R LRRA  S+          WH   R S  R            +    +W+   
Sbjct: 128 RWHSEQRLLRRAKRSVHFNDPKYPQQWHLNNRRSPGR-----------DINVTGVWERNV 176

Query: 208 TGANVRVAVFDTG----LSEKHPHFKNVKERTNWTNERT------LDDGLGHGTFVAGVI 257
           TG  V V V D G    + +  P++         +N+        +++G  HGT  AG I
Sbjct: 177 TGRGVTVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEI 236

Query: 258 ASMRE----CQGFAPDAELHIFRVFTNNQVSYTSWFLDAFN--YAILKKIDVLNLSIGGP 311
           A++        G A  + +   RV         S    AFN  Y I    D+ + S G  
Sbjct: 237 AAVPNNSFCAVGVAYGSRIAGIRVLDGPLTD--SMEAVAFNKHYQIN---DIYSCSWGPD 291

Query: 312 DFMDHPFVDKVWELTANNV-------------IMVSAIGNDGPLYGTLNNP--ADQMDVI 356
           D  D   VD   +L    +             I V A GN G      N    A+ +  +
Sbjct: 292 D--DGKTVDGPHQLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTV 349

Query: 357 GVGGIDFEDNIARFSSR--GMTTWELPGGYGRMKPDIVTYGAGVRGSGVKGGCRALSGTS 414
            +G +D E  +  ++     M      GG   ++  + T     +G+G   G    +GTS
Sbjct: 350 TIGAVDEEGRMPFYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGH---TGTS 406

Query: 415 VASPVVAGAVTLLVSTVQKRELVNPASMKQALIASARRL-----------PGVNMFEQGH 463
            A+P+ AG + L+   +Q R  +    ++  ++ +A R             G +   Q H
Sbjct: 407 AAAPLAAGMIALM---LQVRPCLTWRDVQHIIVFTATRYEDRRAEWVTNEAGFSHSHQ-H 462

Query: 464 GKLDLLRAYQILNSYKPQASLSPSYIDLTECPYMWPYCS 502
           G   LL A++++N+ K   S+          PY+  Y S
Sbjct: 463 G-FGLLNAWRLVNAAKIWTSV----------PYLASYVS 490


>gi|5902808 bone morphogenetic protein 1 isoform 2 precursor [Homo
           sapiens]
          Length = 823

 Score = 33.9 bits (76), Expect = 0.83
 Identities = 34/112 (30%), Positives = 48/112 (42%), Gaps = 26/112 (23%)

Query: 811 GLEVLKQETAVVENVPILGLYQIPAEGGGRIVLYGDSNCLDDSHRQKDCFWLLDALLQYT 870
           GLE+L    A+V+ VP       P        L+GD++    +H    C      + Q T
Sbjct: 716 GLELLLCPHALVDTVPA------PPSA-----LHGDTHAHTHTHVHTHC-----PIAQET 759

Query: 871 SYGVTPPSLSHSGNRQRPPSGAGSVTPERMEGNHLHRYSKVLEAHLGDPKPR 922
             G  PP     G  +  P G G +T    EG++L  +    + H GDPKPR
Sbjct: 760 CRG--PPL----GASRLSPQGPGHLTLAPQEGSYLDFW----DTHRGDPKPR 801


>gi|170784869 tetratricopeptide repeat domain 13 isoform b [Homo
           sapiens]
          Length = 807

 Score = 33.9 bits (76), Expect = 0.83
 Identities = 33/122 (27%), Positives = 52/122 (42%), Gaps = 16/122 (13%)

Query: 889 PSGAGSVTPERMEGNHLHRYSKVLEAHLGDPKPR-----PLPACPRLSWAKPQP-LNETA 942
           P      +PE ++  +L  YS+ L AHL  P         LP   +  WAK  P L E  
Sbjct: 363 PLPGQKASPEYLKVKYLREYSRYLHAHLDTPLTEYNIDVDLPGSFKDHWAKNLPFLIED- 421

Query: 943 PSNLWKHQKLLSIDLDKVVLPNFRSNRPQVRPL-----SPGESGAWDIPGGIMPGRYNQE 997
               ++ Q  L   +  V+  NF S +P+V+ L       G    ++ PG +   R ++ 
Sbjct: 422 ----YEEQPGLQPHIKDVLHQNFESYKPEVQELICVADRLGSLMQYETPGFLPNKRIHRA 477

Query: 998 VG 999
           +G
Sbjct: 478 MG 479


>gi|170784867 tetratricopeptide repeat domain 13 isoform a [Homo
           sapiens]
          Length = 860

 Score = 33.9 bits (76), Expect = 0.83
 Identities = 33/122 (27%), Positives = 52/122 (42%), Gaps = 16/122 (13%)

Query: 889 PSGAGSVTPERMEGNHLHRYSKVLEAHLGDPKPR-----PLPACPRLSWAKPQP-LNETA 942
           P      +PE ++  +L  YS+ L AHL  P         LP   +  WAK  P L E  
Sbjct: 416 PLPGQKASPEYLKVKYLREYSRYLHAHLDTPLTEYNIDVDLPGSFKDHWAKNLPFLIED- 474

Query: 943 PSNLWKHQKLLSIDLDKVVLPNFRSNRPQVRPL-----SPGESGAWDIPGGIMPGRYNQE 997
               ++ Q  L   +  V+  NF S +P+V+ L       G    ++ PG +   R ++ 
Sbjct: 475 ----YEEQPGLQPHIKDVLHQNFESYKPEVQELICVADRLGSLMQYETPGFLPNKRIHRA 530

Query: 998 VG 999
           +G
Sbjct: 531 MG 532


>gi|20336246 proprotein convertase subtilisin/kexin type 5
           preproprotein [Homo sapiens]
          Length = 913

 Score = 33.1 bits (74), Expect = 1.4
 Identities = 11/24 (45%), Positives = 15/24 (62%)

Query: 203 WQMGYTGANVRVAVFDTGLSEKHP 226
           W+ GYTG N+ V + D G+   HP
Sbjct: 156 WKRGYTGKNIVVTILDDGIERTHP 179


>gi|11034849 ectonucleotide pyrophosphatase/phosphodiesterase 5
            (putative function) [Homo sapiens]
          Length = 477

 Score = 32.3 bits (72), Expect = 2.4
 Identities = 26/87 (29%), Positives = 38/87 (43%), Gaps = 18/87 (20%)

Query: 938  LNETA-PSN--LWKHQKLLSIDLDKVVLPNFRSNRPQVRPLSPGESGAWDIPGGIMPGRY 994
            LN TA P N   W  Q LL+  + +VV               P       +PG + P  Y
Sbjct: 381  LNITAMPHNGSFWNVQDLLNSAMPRVV---------------PYTQSTILLPGSVKPAEY 425

Query: 995  NQEVGQTIPVFAFLGAMVVLAFFVVQI 1021
            +QE      +   LG+++V+ FFV+ I
Sbjct: 426  DQEGSYPYFIGVSLGSIIVIVFFVIFI 452


>gi|115298654 mutY homolog isoform 4 [Homo sapiens]
          Length = 521

 Score = 32.0 bits (71), Expect = 3.1
 Identities = 17/48 (35%), Positives = 24/48 (50%)

Query: 150 TRWSQKWQSSRPLRRASLSLGSGFWHATGRHSSRRLLRAIPRQVAQTL 197
           T W QKW + + L  ASL   +  W   G +S  R L+   R+V + L
Sbjct: 122 TGWMQKWPTLQDLASASLEEVNQLWAGLGYYSRGRRLQEGARKVVEEL 169


>gi|115298652 mutY homolog isoform 4 [Homo sapiens]
          Length = 521

 Score = 32.0 bits (71), Expect = 3.1
 Identities = 17/48 (35%), Positives = 24/48 (50%)

Query: 150 TRWSQKWQSSRPLRRASLSLGSGFWHATGRHSSRRLLRAIPRQVAQTL 197
           T W QKW + + L  ASL   +  W   G +S  R L+   R+V + L
Sbjct: 122 TGWMQKWPTLQDLASASLEEVNQLWAGLGYYSRGRRLQEGARKVVEEL 169


>gi|115298650 mutY homolog isoform 3 [Homo sapiens]
          Length = 522

 Score = 32.0 bits (71), Expect = 3.1
 Identities = 17/48 (35%), Positives = 24/48 (50%)

Query: 150 TRWSQKWQSSRPLRRASLSLGSGFWHATGRHSSRRLLRAIPRQVAQTL 197
           T W QKW + + L  ASL   +  W   G +S  R L+   R+V + L
Sbjct: 123 TGWMQKWPTLQDLASASLEEVNQLWAGLGYYSRGRRLQEGARKVVEEL 170


>gi|115298648 mutY homolog isoform 2 [Homo sapiens]
          Length = 535

 Score = 32.0 bits (71), Expect = 3.1
 Identities = 17/48 (35%), Positives = 24/48 (50%)

Query: 150 TRWSQKWQSSRPLRRASLSLGSGFWHATGRHSSRRLLRAIPRQVAQTL 197
           T W QKW + + L  ASL   +  W   G +S  R L+   R+V + L
Sbjct: 136 TGWMQKWPTLQDLASASLEEVNQLWAGLGYYSRGRRLQEGARKVVEEL 183


>gi|6912520 mutY homolog isoform 1 [Homo sapiens]
          Length = 546

 Score = 32.0 bits (71), Expect = 3.1
 Identities = 17/48 (35%), Positives = 24/48 (50%)

Query: 150 TRWSQKWQSSRPLRRASLSLGSGFWHATGRHSSRRLLRAIPRQVAQTL 197
           T W QKW + + L  ASL   +  W   G +S  R L+   R+V + L
Sbjct: 147 TGWMQKWPTLQDLASASLEEVNQLWAGLGYYSRGRRLQEGARKVVEEL 194


>gi|190358497 mutY homolog isoform 5 [Homo sapiens]
          Length = 549

 Score = 32.0 bits (71), Expect = 3.1
 Identities = 17/48 (35%), Positives = 24/48 (50%)

Query: 150 TRWSQKWQSSRPLRRASLSLGSGFWHATGRHSSRRLLRAIPRQVAQTL 197
           T W QKW + + L  ASL   +  W   G +S  R L+   R+V + L
Sbjct: 150 TGWMQKWPTLQDLASASLEEVNQLWAGLGYYSRGRRLQEGARKVVEEL 197


>gi|4505579 furin preproprotein [Homo sapiens]
          Length = 794

 Score = 32.0 bits (71), Expect = 3.1
 Identities = 11/30 (36%), Positives = 16/30 (53%)

Query: 197 LQADVLWQMGYTGANVRVAVFDTGLSEKHP 226
           L     W  GYTG  + V++ D G+ + HP
Sbjct: 132 LNVKAAWAQGYTGHGIVVSILDDGIEKNHP 161


>gi|58331242 formin homology 2 domain containing 3 [Homo sapiens]
          Length = 1439

 Score = 32.0 bits (71), Expect = 3.1
 Identities = 17/59 (28%), Positives = 30/59 (50%)

Query: 119 DHPNIKRVTPQRKVFRSLKYAESDPTVPCNETRWSQKWQSSRPLRRASLSLGSGFWHAT 177
           +H  + R   +R   +S+K   S PT PC+++  S K    R LR    + G+  +H++
Sbjct: 353 EHRGLDRRRSRRHSVQSIKSTLSAPTSPCSQSAPSFKPNQVRDLREKYSNFGNNSYHSS 411


>gi|27262667 colony stimulating factor 1 isoform a precursor [Homo
           sapiens]
          Length = 554

 Score = 30.8 bits (68), Expect = 7.0
 Identities = 29/90 (32%), Positives = 37/90 (41%), Gaps = 10/90 (11%)

Query: 893 GSVTPERMEGNHLHRYSKVLEAHLGDPKPRPLPACPRLSWAKPQPLNETAPSNLWKHQKL 952
           G V P   + NH  + +    A L DP   P P  PR+S  +PQ L+   PS L    +L
Sbjct: 371 GPVRPTGQDWNHTPQKTDHPSALLRDP---PEPGSPRISSLRPQGLSN--PSTLSAQPQL 425

Query: 953 LSIDLDKVVLP-----NFRSNRPQVRPLSP 977
                   VLP       RS R +  P  P
Sbjct: 426 SRSHSSGSVLPLGELEGRRSTRDRRSPAEP 455


>gi|27262661 colony stimulating factor 1 isoform a precursor [Homo
           sapiens]
          Length = 554

 Score = 30.8 bits (68), Expect = 7.0
 Identities = 29/90 (32%), Positives = 37/90 (41%), Gaps = 10/90 (11%)

Query: 893 GSVTPERMEGNHLHRYSKVLEAHLGDPKPRPLPACPRLSWAKPQPLNETAPSNLWKHQKL 952
           G V P   + NH  + +    A L DP   P P  PR+S  +PQ L+   PS L    +L
Sbjct: 371 GPVRPTGQDWNHTPQKTDHPSALLRDP---PEPGSPRISSLRPQGLSN--PSTLSAQPQL 425

Query: 953 LSIDLDKVVLP-----NFRSNRPQVRPLSP 977
                   VLP       RS R +  P  P
Sbjct: 426 SRSHSSGSVLPLGELEGRRSTRDRRSPAEP 455


>gi|91718902 myeloid/lymphoid or mixed-lineage leukemia 3 [Homo
            sapiens]
          Length = 4911

 Score = 30.8 bits (68), Expect = 7.0
 Identities = 17/50 (34%), Positives = 23/50 (46%)

Query: 881  HSGNRQRPPSGAGSVTPERMEGNHLHRYSKVLEAHLGDPKPRPLPACPRL 930
            H G+R  P S   S +PE + G  + RY  +       P+P P P  P L
Sbjct: 3991 HCGDRDTPDSFVPSSSPESVVGVEVSRYPDLSLVKEEPPEPVPSPIIPIL 4040


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.136    0.423 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 44,166,414
Number of Sequences: 37866
Number of extensions: 2158056
Number of successful extensions: 5273
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 21
Number of HSP's successfully gapped in prelim test: 9
Number of HSP's that attempted gapping in prelim test: 5233
Number of HSP's gapped (non-prelim): 47
length of query: 1052
length of database: 18,247,518
effective HSP length: 113
effective length of query: 939
effective length of database: 13,968,660
effective search space: 13116571740
effective search space used: 13116571740
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.