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Search of human proteins with 4506221
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4506221 proteasome 26S non-ATPase subunit 12 isoform 1 [Homo
sapiens]
(456 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4506221 proteasome 26S non-ATPase subunit 12 isoform 1 [Homo ... 890 0.0
gi|28872765 proteasome 26S non-ATPase subunit 12 isoform 2 [Homo... 842 0.0
gi|38373690 COP9 signalosome subunit 4 [Homo sapiens] 84 3e-16
gi|219842262 COP9 constitutive photomorphogenic homolog subunit ... 41 0.003
gi|4759264 COP9 constitutive photomorphogenic homolog subunit 2 ... 41 0.003
gi|31982906 cingulin-like 1 [Homo sapiens] 37 0.028
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 37 0.037
gi|22208850 Golgi coiled-coil protein 1 [Homo sapiens] 37 0.049
gi|187761324 shootin1 isoform a [Homo sapiens] 36 0.063
gi|50511340 shootin1 isoform b [Homo sapiens] 36 0.063
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 36 0.063
gi|156104908 myosin heavy chain 6 [Homo sapiens] 36 0.083
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 36 0.083
gi|157738667 FYVE and coiled-coil domain containing 1 [Homo sapi... 35 0.11
gi|115511012 coiled-coil domain containing 136 [Homo sapiens] 35 0.18
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 34 0.24
gi|82880656 coiled-coil domain containing 46 isoform a [Homo sap... 34 0.24
gi|64085252 hypothetical protein LOC145508 [Homo sapiens] 33 0.41
gi|51479166 bicaudal D homolog 2 isoform 1 [Homo sapiens] 33 0.54
gi|21735417 bicaudal D homolog 2 isoform 2 [Homo sapiens] 33 0.54
gi|219689136 coiled-coil domain containing 68 [Homo sapiens] 33 0.70
gi|13376818 coiled-coil domain containing 68 [Homo sapiens] 33 0.70
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 33 0.70
gi|154426264 ubiquitin protein ligase E3 component n-recognin 7 ... 33 0.70
gi|154426322 ubiquitin protein ligase E3 component n-recognin 7 ... 33 0.70
gi|23238222 COP9 constitutive photomorphogenic homolog subunit 3... 33 0.70
gi|82880654 coiled-coil domain containing 46 isoform b [Homo sap... 33 0.70
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 33 0.70
gi|7661914 proteasome (prosome, macropain) 26S subunit, non-ATPa... 32 0.91
gi|45439327 periplakin [Homo sapiens] 32 1.2
>gi|4506221 proteasome 26S non-ATPase subunit 12 isoform 1 [Homo
sapiens]
Length = 456
Score = 890 bits (2301), Expect = 0.0
Identities = 456/456 (100%), Positives = 456/456 (100%)
Query: 1 MADGGSERADGRIVKMEVDYSATVDQRLPECAKLAKEGRLQEVIETLLSLEKQTRTASDM 60
MADGGSERADGRIVKMEVDYSATVDQRLPECAKLAKEGRLQEVIETLLSLEKQTRTASDM
Sbjct: 1 MADGGSERADGRIVKMEVDYSATVDQRLPECAKLAKEGRLQEVIETLLSLEKQTRTASDM 60
Query: 61 VSTSRILVAVVKMCYEAKEWDLLNENIMLLSKRRSQLKQAVAKMVQQCCTYVEEITDLPI 120
VSTSRILVAVVKMCYEAKEWDLLNENIMLLSKRRSQLKQAVAKMVQQCCTYVEEITDLPI
Sbjct: 61 VSTSRILVAVVKMCYEAKEWDLLNENIMLLSKRRSQLKQAVAKMVQQCCTYVEEITDLPI 120
Query: 121 KLRLIDTLRMVTEGKIYVEIERARLTKTLATIKEQNGDVKEAASILQELQVETYGSMEKK 180
KLRLIDTLRMVTEGKIYVEIERARLTKTLATIKEQNGDVKEAASILQELQVETYGSMEKK
Sbjct: 121 KLRLIDTLRMVTEGKIYVEIERARLTKTLATIKEQNGDVKEAASILQELQVETYGSMEKK 180
Query: 181 ERVEFILEQMRLCLAVKDYIRTQIISKKINTKFFQEENTEKLKLKYYNLMIQLDQHEGSY 240
ERVEFILEQMRLCLAVKDYIRTQIISKKINTKFFQEENTEKLKLKYYNLMIQLDQHEGSY
Sbjct: 181 ERVEFILEQMRLCLAVKDYIRTQIISKKINTKFFQEENTEKLKLKYYNLMIQLDQHEGSY 240
Query: 241 LSICKHYRAIYDTPCIQAESEKWQQALKSVVLYVILAPFDNEQSDLVHRISGDKKLEEIP 300
LSICKHYRAIYDTPCIQAESEKWQQALKSVVLYVILAPFDNEQSDLVHRISGDKKLEEIP
Sbjct: 241 LSICKHYRAIYDTPCIQAESEKWQQALKSVVLYVILAPFDNEQSDLVHRISGDKKLEEIP 300
Query: 301 KYKDLLKLFTTMELMRWSTLVEDYGMELRKGSLESPATDVFGSTEEGEKRWKDLKNRVVE 360
KYKDLLKLFTTMELMRWSTLVEDYGMELRKGSLESPATDVFGSTEEGEKRWKDLKNRVVE
Sbjct: 301 KYKDLLKLFTTMELMRWSTLVEDYGMELRKGSLESPATDVFGSTEEGEKRWKDLKNRVVE 360
Query: 361 HNIRIMAKYYTRITMKRMAQLLDLSVDESEAFLSNLVVNKTIFAKVDRLAGIINFQRPKD 420
HNIRIMAKYYTRITMKRMAQLLDLSVDESEAFLSNLVVNKTIFAKVDRLAGIINFQRPKD
Sbjct: 361 HNIRIMAKYYTRITMKRMAQLLDLSVDESEAFLSNLVVNKTIFAKVDRLAGIINFQRPKD 420
Query: 421 PNNLLNDWSQKLNSLMSLVNKTTHLIAKEEMIHNLQ 456
PNNLLNDWSQKLNSLMSLVNKTTHLIAKEEMIHNLQ
Sbjct: 421 PNNLLNDWSQKLNSLMSLVNKTTHLIAKEEMIHNLQ 456
>gi|28872765 proteasome 26S non-ATPase subunit 12 isoform 2 [Homo
sapiens]
Length = 436
Score = 842 bits (2176), Expect = 0.0
Identities = 436/456 (95%), Positives = 436/456 (95%), Gaps = 20/456 (4%)
Query: 1 MADGGSERADGRIVKMEVDYSATVDQRLPECAKLAKEGRLQEVIETLLSLEKQTRTASDM 60
MADGGSERADGRIVKMEVDYSATVDQRLPECAKLAK ASDM
Sbjct: 1 MADGGSERADGRIVKMEVDYSATVDQRLPECAKLAK--------------------ASDM 40
Query: 61 VSTSRILVAVVKMCYEAKEWDLLNENIMLLSKRRSQLKQAVAKMVQQCCTYVEEITDLPI 120
VSTSRILVAVVKMCYEAKEWDLLNENIMLLSKRRSQLKQAVAKMVQQCCTYVEEITDLPI
Sbjct: 41 VSTSRILVAVVKMCYEAKEWDLLNENIMLLSKRRSQLKQAVAKMVQQCCTYVEEITDLPI 100
Query: 121 KLRLIDTLRMVTEGKIYVEIERARLTKTLATIKEQNGDVKEAASILQELQVETYGSMEKK 180
KLRLIDTLRMVTEGKIYVEIERARLTKTLATIKEQNGDVKEAASILQELQVETYGSMEKK
Sbjct: 101 KLRLIDTLRMVTEGKIYVEIERARLTKTLATIKEQNGDVKEAASILQELQVETYGSMEKK 160
Query: 181 ERVEFILEQMRLCLAVKDYIRTQIISKKINTKFFQEENTEKLKLKYYNLMIQLDQHEGSY 240
ERVEFILEQMRLCLAVKDYIRTQIISKKINTKFFQEENTEKLKLKYYNLMIQLDQHEGSY
Sbjct: 161 ERVEFILEQMRLCLAVKDYIRTQIISKKINTKFFQEENTEKLKLKYYNLMIQLDQHEGSY 220
Query: 241 LSICKHYRAIYDTPCIQAESEKWQQALKSVVLYVILAPFDNEQSDLVHRISGDKKLEEIP 300
LSICKHYRAIYDTPCIQAESEKWQQALKSVVLYVILAPFDNEQSDLVHRISGDKKLEEIP
Sbjct: 221 LSICKHYRAIYDTPCIQAESEKWQQALKSVVLYVILAPFDNEQSDLVHRISGDKKLEEIP 280
Query: 301 KYKDLLKLFTTMELMRWSTLVEDYGMELRKGSLESPATDVFGSTEEGEKRWKDLKNRVVE 360
KYKDLLKLFTTMELMRWSTLVEDYGMELRKGSLESPATDVFGSTEEGEKRWKDLKNRVVE
Sbjct: 281 KYKDLLKLFTTMELMRWSTLVEDYGMELRKGSLESPATDVFGSTEEGEKRWKDLKNRVVE 340
Query: 361 HNIRIMAKYYTRITMKRMAQLLDLSVDESEAFLSNLVVNKTIFAKVDRLAGIINFQRPKD 420
HNIRIMAKYYTRITMKRMAQLLDLSVDESEAFLSNLVVNKTIFAKVDRLAGIINFQRPKD
Sbjct: 341 HNIRIMAKYYTRITMKRMAQLLDLSVDESEAFLSNLVVNKTIFAKVDRLAGIINFQRPKD 400
Query: 421 PNNLLNDWSQKLNSLMSLVNKTTHLIAKEEMIHNLQ 456
PNNLLNDWSQKLNSLMSLVNKTTHLIAKEEMIHNLQ
Sbjct: 401 PNNLLNDWSQKLNSLMSLVNKTTHLIAKEEMIHNLQ 436
>gi|38373690 COP9 signalosome subunit 4 [Homo sapiens]
Length = 406
Score = 83.6 bits (205), Expect = 3e-16
Identities = 86/370 (23%), Positives = 169/370 (45%), Gaps = 34/370 (9%)
Query: 82 LLNENIMLLSKRRSQLKQAVAKMVQQCCTYVEEITDLPIKLRLIDTLRMVTEGKIYVEIE 141
++NEN+ L+ R+ ++ CT++ + D K TL + I E +
Sbjct: 52 MVNENVSLVISRQ---------LLTDFCTHLPNLPDSTAKEIYHFTLEKIQPRVISFEEQ 102
Query: 142 RARLTKTLATIKEQNGDVKEAASILQELQVETYGSMEKKE-RVEFILEQMRLCLAVKDYI 200
A + + LA+I E+ D + AA +L + +ET + ++E L+ RL L D +
Sbjct: 103 VASIRQHLASIYEKEEDWRNAAQVLVGIPLETGQKQYNVDYKLETYLKIARLYLEDDDPV 162
Query: 201 RTQIISKKINTKFFQEENT-EKLKLKYYNLMIQLDQHEGSYLSICKHYRAI-YDTPCIQA 258
+ + + + Q E+T E+L++ Y ++ + ++ + Y + Y T I
Sbjct: 163 QAEAYINRAS--LLQNESTNEQLQIHYKVCYARVLDYRRKFIEAAQRYNELSYKT--IVH 218
Query: 259 ESEKWQQALKSVVLYVILAPFDNEQSDLVHRISGDKKLEEIPKYKDLLKLFTTMELMRWS 318
ESE+ + ALK + ILA ++S ++ + D++ +++ Y L K++ ++R +
Sbjct: 219 ESERLE-ALKHALHCTILASAGQQRSRMLATLFKDERCQQLAAYGILEKMYLD-RIIRGN 276
Query: 319 TLVEDYGMELRKGSLESPATDVFGSTEEGEKRWKDLKNRVVEHNIRIMAKYYTRITMKRM 378
L E M + AT GS+ L V+EHN+ +K Y IT + +
Sbjct: 277 QLQEFAAMLMP----HQKATTADGSSI--------LDRAVIEHNLLSASKLYNNITFEEL 324
Query: 379 AQLLDLSVDESEAFLSNLVVNKTIFAKVDRLAGIINFQRPKDPNNLLNDWSQKLNSLMSL 438
LL++ ++E S ++ + +D++ GI++F + L W +++ SL
Sbjct: 325 GALLEIPAAKAEKIASQMITEGRMNGFIDQIDGIVHF----ETREALPTWDKQIQSLCFQ 380
Query: 439 VNKTTHLIAK 448
VN I++
Sbjct: 381 VNNLLEKISQ 390
>gi|219842262 COP9 constitutive photomorphogenic homolog subunit 2
isoform 2 [Homo sapiens]
Length = 450
Score = 40.8 bits (94), Expect = 0.003
Identities = 56/319 (17%), Positives = 137/319 (42%), Gaps = 49/319 (15%)
Query: 134 GKIYVEIER-ARLTKTLATIKEQ------NGDVKEAASILQ--ELQVETYGSMEKKERVE 184
GK+Y+E E +L K L + + D+K+ +L+ L+++ Y + + ++++
Sbjct: 163 GKLYLEREEYGKLQKILRQLHQSCQTDDGEDDLKKGTQLLEIYALEIQMYTAQKNNKKLK 222
Query: 185 FILEQ-MRLCLAVKDYIRTQIISKKINTKFFQEENTEKLKLKYYNLMIQLDQHEGSYLSI 243
+ EQ + + A+ + +I + +E EK ++ D+ +
Sbjct: 223 ALYEQSLHIKSAIPHPLIMGVIRECGGKMHLREGEFEKAHTDFFEAFKNYDESGSPRRTT 282
Query: 244 CKHYRAIYDTPCIQAESEKWQQALKSVVLYVILAPFDNEQSDLVHRISGDKKLEEIPKYK 303
C Y L ++++ + PFD++++ K EI
Sbjct: 283 CLKYLV-----------------LANMLMKSGINPFDSQEAKPY------KNDPEILAMT 319
Query: 304 DLLKLFTTMELMRWSTLVEDYGMELRKGSLESPATDVFGSTEEGEKRWKDLKNRVVEHNI 363
+L+ + ++ + +++ + ++ P E E+ ++++ +V+ I
Sbjct: 320 NLVSAYQNNDITEFEKILKTNHSNI----MDDPFI-----REHIEELLRNIRTQVL---I 367
Query: 364 RIMAKYYTRITMKRMAQLLDLSVDESEAFLSNLVVNKTIFAKVDRLAGIINFQRPKDPN- 422
+++ K YTRI + +++ L++ V + E+ L +++ TI ++D++ ++ K
Sbjct: 368 KLI-KPYTRIHIPFISKELNIDVADVESLLVQCILDNTIHGRIDQVNQLLELDHQKRGGA 426
Query: 423 --NLLNDWSQKLNSLMSLV 439
L+ W+ +LNSL V
Sbjct: 427 RYTALDKWTNQLNSLNQAV 445
>gi|4759264 COP9 constitutive photomorphogenic homolog subunit 2
isoform 1 [Homo sapiens]
Length = 443
Score = 40.8 bits (94), Expect = 0.003
Identities = 56/319 (17%), Positives = 137/319 (42%), Gaps = 49/319 (15%)
Query: 134 GKIYVEIER-ARLTKTLATIKEQ------NGDVKEAASILQ--ELQVETYGSMEKKERVE 184
GK+Y+E E +L K L + + D+K+ +L+ L+++ Y + + ++++
Sbjct: 156 GKLYLEREEYGKLQKILRQLHQSCQTDDGEDDLKKGTQLLEIYALEIQMYTAQKNNKKLK 215
Query: 185 FILEQ-MRLCLAVKDYIRTQIISKKINTKFFQEENTEKLKLKYYNLMIQLDQHEGSYLSI 243
+ EQ + + A+ + +I + +E EK ++ D+ +
Sbjct: 216 ALYEQSLHIKSAIPHPLIMGVIRECGGKMHLREGEFEKAHTDFFEAFKNYDESGSPRRTT 275
Query: 244 CKHYRAIYDTPCIQAESEKWQQALKSVVLYVILAPFDNEQSDLVHRISGDKKLEEIPKYK 303
C Y L ++++ + PFD++++ K EI
Sbjct: 276 CLKYLV-----------------LANMLMKSGINPFDSQEAKPY------KNDPEILAMT 312
Query: 304 DLLKLFTTMELMRWSTLVEDYGMELRKGSLESPATDVFGSTEEGEKRWKDLKNRVVEHNI 363
+L+ + ++ + +++ + ++ P E E+ ++++ +V+ I
Sbjct: 313 NLVSAYQNNDITEFEKILKTNHSNI----MDDPFI-----REHIEELLRNIRTQVL---I 360
Query: 364 RIMAKYYTRITMKRMAQLLDLSVDESEAFLSNLVVNKTIFAKVDRLAGIINFQRPKDPN- 422
+++ K YTRI + +++ L++ V + E+ L +++ TI ++D++ ++ K
Sbjct: 361 KLI-KPYTRIHIPFISKELNIDVADVESLLVQCILDNTIHGRIDQVNQLLELDHQKRGGA 419
Query: 423 --NLLNDWSQKLNSLMSLV 439
L+ W+ +LNSL V
Sbjct: 420 RYTALDKWTNQLNSLNQAV 438
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 37.4 bits (85), Expect = 0.028
Identities = 79/407 (19%), Positives = 164/407 (40%), Gaps = 36/407 (8%)
Query: 10 DGRIVKMEVDYSATVDQRLPECAKLAKEGRLQEVIETLLSLEKQTRTASDMVSTSRILVA 69
DG++++ E +TV + A+ KE ++ TL+ + T T+ D + +
Sbjct: 467 DGKVLETEGSQESTVIRAPSLGAQSKKEEEVKTATATLMLQNRATATSPDSGAKKISVKT 526
Query: 70 VVKMCYEAKEWDLLNENIMLLSKRRSQ-LKQAVAKMVQQCCTYVEEITDLPIKL--RLID 126
DLL L + + KQ + +++ T ++ T + L I
Sbjct: 527 FPSASNTQATPDLLKGQQELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQ 586
Query: 127 TLRMVTEGKIYVEIERARLTKTLATIKEQNGDVK-EAASILQELQVETYGSM---EKKER 182
TL+ G + T + + EQ + E A + ++LQ+E E++ER
Sbjct: 587 TLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERER 646
Query: 183 VEFILEQMRLCLAVKDYIRTQIISKKINTKFFQEENTEKLKLKYYNLMIQLDQHEGSYLS 242
+ LE++R K + + + ++ +N E+L + + ++ +QH+
Sbjct: 647 MRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEEL----FQVKMEREQHQTEIRD 702
Query: 243 ICKHYRAIYDTPCIQAESEKWQQALKSVVLYVILAPFD--------NEQSDLVHRISGDK 294
+ ++D SE ++ +++ ++ A D EQ DL+ K
Sbjct: 703 LQDQLSEMHDELDSAKRSEDREKG--ALIEELLQAKQDLQDLLIAKEEQEDLLR-----K 755
Query: 295 KLEEIPKYKDLLKLFTTMELMRWSTLVEDYGMELR--KGSLESPATDV-----FGSTEEG 347
+ E+ K LK + L E Y EL+ + S+E +V +T E
Sbjct: 756 RERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQ 815
Query: 348 EKRWKDLKNRVV-EHNIRIM--AKYYTRITMKRMAQLLDLSVDESEA 391
++ +++ +++ E N ++ ++ R + Q+ DL DE++A
Sbjct: 816 DQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKA 862
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 37.0 bits (84), Expect = 0.037
Identities = 47/206 (22%), Positives = 89/206 (43%), Gaps = 35/206 (16%)
Query: 33 KLAKEGRLQEVIETLLSLEKQTRTASDMVSTSRILVAVVKMCYEAKEWDLLNENIMLLSK 92
+LA E RL E+ ETL Q++ ++ + L A ++C EA+E L
Sbjct: 861 QLAAENRLTEM-ETL-----QSQLMAEKLQLQEQLQAETELCAEAEE----------LRA 904
Query: 93 RRSQLKQAVAKMVQQCCTYVEEITDLPIKLRLIDTLRMVTEGKIYVEIERARLTKTLATI 152
R + KQ + ++ VEE E +++ E+ ++ + + +
Sbjct: 905 RLTAKKQELEEICHDLEARVEE----------------EEERCQHLQAEKKKMQQNIQEL 948
Query: 153 KEQNGDVKEAASILQELQVETYGSMEKKERVEFILEQMRLCLAVKDYIRTQIISKKINTK 212
+EQ + + A LQ +V T ++K E + ILE LA + + I++
Sbjct: 949 EEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNL 1008
Query: 213 FFQEENTE---KLKLKYYNLMIQLDQ 235
+EE ++ KLK K+ ++ L++
Sbjct: 1009 TEEEEKSKSLAKLKNKHEAMITDLEE 1034
>gi|22208850 Golgi coiled-coil protein 1 [Homo sapiens]
Length = 775
Score = 36.6 bits (83), Expect = 0.049
Identities = 40/152 (26%), Positives = 65/152 (42%), Gaps = 20/152 (13%)
Query: 90 LSKRRSQLKQAVAKMVQQCCTYVEEITDLPIKLRLIDTLRM---VTEGKIYVEIERARLT 146
+ KR QLK +A + T +E + + L D +M + + E ERARL
Sbjct: 154 VDKRLHQLKTQLATLTSSLATVTQEKSRMEASY-LADKKKMKQDLEDASNKAEEERARLE 212
Query: 147 KTLATIKEQNGDVK---------------EAASILQELQVETYGSMEKKERVEFILEQMR 191
L ++EQ + K + A +L+ELQ +++ +E LE+ R
Sbjct: 213 GELKGLQEQIAETKARLITQQHDRAQEQSDHALMLRELQKLLQEERTQRQDLELRLEETR 272
Query: 192 LCLAVKDYIRTQIISKKINTKFFQEENTEKLK 223
LA + Y Q+ ++ TK E E+LK
Sbjct: 273 EALAGRAYAAEQMEGFELQTKQLTRE-VEELK 303
>gi|187761324 shootin1 isoform a [Homo sapiens]
Length = 631
Score = 36.2 bits (82), Expect = 0.063
Identities = 71/325 (21%), Positives = 131/325 (40%), Gaps = 59/325 (18%)
Query: 48 LSLEKQTRTASDMVSTS----RILVAVVKMCYEAKEW-DLLNENIMLLSKRRSQLKQAVA 102
L +EK R +++ ++T + + M Y AK D++ E I + + + A
Sbjct: 73 LEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDDEDSTTDTDGAA 132
Query: 103 K--MVQQCCTYVEEITDLPIKLRLIDTLRMVTEGKIYVEIERARLTKTLATIKEQNGDVK 160
+ + QC ++E+ D + V E K + IE L L + E+ VK
Sbjct: 133 ETCVSVQCQKQIKELRDQIVS---------VQEEKKILAIELENLKSKLVEVIEEVNKVK 183
Query: 161 EAASILQELQVETYGSMEKKERVEFILEQMRLCLAVKDYIRTQI---ISKKINTK---FF 214
+ ++L +E +EK RV LAV++Y Q+ + K + K F
Sbjct: 184 QEKTVLNSEVLEQRKVLEKCNRVSM--------LAVEEYEEMQVNLELEKDLRKKAESFA 235
Query: 215 QEENTEKLKLK-YYNLMIQLDQHEGSYLSICKHYRAIYDTPCIQAESEKWQQALKSVVLY 273
QE E+ KLK +L++Q + L + T ++ E + QQ +K +
Sbjct: 236 QEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENAKL--TQQLEEERIQHQQKVKEL--- 290
Query: 274 VILAPFDNEQSDLVHRISGDKKLEEIPKYKDLLKLFTTMELMRWSTLVEDYGMELRKGSL 333
+++LE +K++ L +EL+ + +EL+ +
Sbjct: 291 -------------------EEQLENETLHKEIHNLKQQLELLE----EDKKELELKYQNS 327
Query: 334 ESPATDVFGSTEEGEKRWKDLKNRV 358
E A ++ S +E +KR +N V
Sbjct: 328 EEKARNLKHSVDELQKRVNQSENSV 352
>gi|50511340 shootin1 isoform b [Homo sapiens]
Length = 456
Score = 36.2 bits (82), Expect = 0.063
Identities = 71/325 (21%), Positives = 131/325 (40%), Gaps = 59/325 (18%)
Query: 48 LSLEKQTRTASDMVSTS----RILVAVVKMCYEAKEW-DLLNENIMLLSKRRSQLKQAVA 102
L +EK R +++ ++T + + M Y AK D++ E I + + + A
Sbjct: 73 LEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDDEDSTTDTDGAA 132
Query: 103 K--MVQQCCTYVEEITDLPIKLRLIDTLRMVTEGKIYVEIERARLTKTLATIKEQNGDVK 160
+ + QC ++E+ D + V E K + IE L L + E+ VK
Sbjct: 133 ETCVSVQCQKQIKELRDQIVS---------VQEEKKILAIELENLKSKLVEVIEEVNKVK 183
Query: 161 EAASILQELQVETYGSMEKKERVEFILEQMRLCLAVKDYIRTQI---ISKKINTK---FF 214
+ ++L +E +EK RV LAV++Y Q+ + K + K F
Sbjct: 184 QEKTVLNSEVLEQRKVLEKCNRVSM--------LAVEEYEEMQVNLELEKDLRKKAESFA 235
Query: 215 QEENTEKLKLK-YYNLMIQLDQHEGSYLSICKHYRAIYDTPCIQAESEKWQQALKSVVLY 273
QE E+ KLK +L++Q + L + T ++ E + QQ +K +
Sbjct: 236 QEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENAKL--TQQLEEERIQHQQKVKEL--- 290
Query: 274 VILAPFDNEQSDLVHRISGDKKLEEIPKYKDLLKLFTTMELMRWSTLVEDYGMELRKGSL 333
+++LE +K++ L +EL+ + +EL+ +
Sbjct: 291 -------------------EEQLENETLHKEIHNLKQQLELLE----EDKKELELKYQNS 327
Query: 334 ESPATDVFGSTEEGEKRWKDLKNRV 358
E A ++ S +E +KR +N V
Sbjct: 328 EEKARNLKHSVDELQKRVNQSENSV 352
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 36.2 bits (82), Expect = 0.063
Identities = 97/466 (20%), Positives = 181/466 (38%), Gaps = 93/466 (19%)
Query: 11 GRIVKMEVDYSATVDQRLPECAKLAKEGRLQEVIETLLSLEKQTRTASDMVSTSRILVAV 70
G +V+ + D + RL E K ++EV L L Q + +S + + +
Sbjct: 1615 GSMVQAKADLQEAL--RLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTL 1672
Query: 71 VKMCYEAKEWDLLNENIMLLSKRRSQLK-------------QAVAKMVQQCCTYVE--EI 115
+K E KE + L + +SK +++LK Q + Q + +E ++
Sbjct: 1673 IKQEIE-KEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQV 1731
Query: 116 TDLPIKLRLIDTLRMVTEGKIYVEIERARLTKTLATIKEQNGDVKEAASILQELQVETYG 175
L KL L + ++ + K +E ++ L + I+ + + S ++ L E
Sbjct: 1732 AVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKED 1791
Query: 176 SMEKKERVEFILEQMRLCLAVKDYIRTQIISKKINTKFFQEENTEKLKLKYYNLMIQLDQ 235
EK + E L Q + LA + N+K ++ N EKL+L L +LDQ
Sbjct: 1792 LQEKCDIWEKKLAQTKRVLAAAEE----------NSKM-EQSNLEKLELNVRKLQQELDQ 1840
Query: 236 HEGSYLSICKHYRAIYDTPCIQAESEKWQQALKSV--VLYVILAPFDNEQSDLVHRISGD 293
LS+ D +Q + ++ ++A+ S+ L + + + DL+H
Sbjct: 1841 LNRDKLSLHN------DISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLH----- 1889
Query: 294 KKLEEIPKYKDLLKLFTT---MELMRWSTLVEDYGMELRKGSLESPATDVFGSTEEGEKR 350
K++D+L T ++ W+ ED E E +++
Sbjct: 1890 -----TTKHQDVLLSEQTRLQKDISEWANRFEDCQKE----------------EETKQQQ 1928
Query: 351 WKDLKNRVVEHNIRIMAKYYTRITMKRMAQLLDLSVDESEAFLSNLVVNKTIFAKVDRLA 410
+ L+N + E+ +++ + + M Q L E E+ S L +K +
Sbjct: 1929 LQVLQNEIEENKLKL-------VQQEMMFQRLQ---KERESEESKLETSKVTLKEQQH-- 1976
Query: 411 GIINFQRPKDPNNLLNDWSQKLNSLMSLVNKTTHLIAKEEMIHNLQ 456
Q K+ L D KL+ ++S V +A EE + LQ
Sbjct: 1977 -----QLEKE----LTDQKSKLDQVLSKV------LAAEERVRTLQ 2007
Score = 29.6 bits (65), Expect = 5.9
Identities = 46/241 (19%), Positives = 99/241 (41%), Gaps = 27/241 (11%)
Query: 78 KEWDLLNENIMLLSKRRSQLKQAVAKMVQQCCTYVEEITDLPIKLRLIDTLRMVTEGKIY 137
++ D++N+ L R ++ +AK ++ E++T+ I + L+ EG I
Sbjct: 562 QQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAAN--EALKKDLEGVI- 618
Query: 138 VEIERARLTKTLATIKEQNGDVKEAASILQELQVETYGSMEKKERVEFILEQMRLCLAVK 197
+ L + L TIK G +A + ++L+ E +++ VE +Q+ +
Sbjct: 619 -----SGLQEYLGTIK---GQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDA 670
Query: 198 DYIRTQIISKKINTKFFQEENTE------KLKLKYYNLMIQLDQHEGSYLSICKHYRAI- 250
+ +R ++ + + E N L L +L+ + + + +
Sbjct: 671 ENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVT 730
Query: 251 ----YDTPCIQAESEKWQQALKSVVLYVILAPFDNEQSDLVHRISGDKKLEEIPKYKDLL 306
+ +QAE EK +QALK+ + + +++ +H KL+ + +LL
Sbjct: 731 RLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENSELH-----AKLKHLQDDNNLL 785
Query: 307 K 307
K
Sbjct: 786 K 786
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 35.8 bits (81), Expect = 0.083
Identities = 49/220 (22%), Positives = 97/220 (44%), Gaps = 29/220 (13%)
Query: 72 KMCYEAKEWDLLNENIMLLSKRRSQLKQAVAKMVQQCCTYVEEITDLPIKLRLIDTLRMV 131
K+ EAK ++ NE + + ++L K+ +C ++I DL + L ++ +
Sbjct: 914 KIQLEAKVKEM-NERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHA 972
Query: 132 TEGKI-YVEIERARLTKTLATIKEQNGDVKEA-ASILQELQVE----------------- 172
TE K+ + E A L + +A + ++ ++EA L +LQVE
Sbjct: 973 TENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQ 1032
Query: 173 ---TYGSMEKKERVEFILEQMRLCLAVKDYIRTQIISKKINTKFFQEENTEKLKLKYYNL 229
GS+E++++V LE+ + L + + I N K E EKLK K +++
Sbjct: 1033 VDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLE---EKLKKKEFDI 1089
Query: 230 MIQLDQHEGSYLSICKHYRAIYDTPCIQAESEKWQQALKS 269
Q + E + + + + + QA E+ ++ L++
Sbjct: 1090 NQQNSKIEDEQVLALQLQKKLKEN---QARIEELEEELEA 1126
Score = 32.7 bits (73), Expect = 0.70
Identities = 34/154 (22%), Positives = 70/154 (45%), Gaps = 10/154 (6%)
Query: 41 QEVIETLLSLEKQTRTASDMVSTSRILVAVVKMCYEAKEWDLLNENIML---LSKRRSQL 97
Q+V + SLE++ + D+ R L +K+ E+ DL N+ + L L K+ +
Sbjct: 1031 QQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESI-MDLENDKLQLEEKLKKKEFDI 1089
Query: 98 KQAVAKMVQQCCTYVEEITDLPIKLRLIDTLRMVTEGKIYVEIERARLTKTLATIKEQNG 157
Q +K+ E++ L ++ +L + + E + +E ER K + +
Sbjct: 1090 NQQNSKIED------EQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSR 1143
Query: 158 DVKEAASILQELQVETYGSMEKKERVEFILEQMR 191
+++E + L+E T +E ++ E ++MR
Sbjct: 1144 ELEEISERLEEAGGATSVQIEMNKKREAEFQKMR 1177
Score = 29.6 bits (65), Expect = 5.9
Identities = 53/243 (21%), Positives = 106/243 (43%), Gaps = 28/243 (11%)
Query: 135 KIYVEIERARLTKTLATIKEQNGDVKEAASILQELQVETYGSMEKKE-RVEFILEQMRLC 193
KI ++ A K +AT+KE+ G +KE ++EK E R + + E+M
Sbjct: 837 KIKPLLKSAETEKEMATMKEEFGRIKE--------------TLEKSEARRKELEEKMVSL 882
Query: 194 LAVKDYIRTQIISKKINTKFFQE------ENTEKLKLKYYNLMIQLDQHEGSYLSICKHY 247
L K+ ++ Q+ +++ N +E +N +L+ K + +L+ E +
Sbjct: 883 LQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKK 942
Query: 248 RAIYDTPCIQAESEKWQQALKSVVLYVILAPFDNEQSDLVHRISG-DKKLEEIPKYKDLL 306
R + D C + + + L + +N+ +L ++G D+ + ++ K K L
Sbjct: 943 RKLED-ECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKAL 1001
Query: 307 KLFTTMELMRWSTLVEDYGMELRKG--SLESPATDVFGSTEEGEKRWKDLK--NRVVEHN 362
+ + + + ED L K LE D+ GS E+ +K DL+ R +E +
Sbjct: 1002 Q-EAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGD 1060
Query: 363 IRI 365
+++
Sbjct: 1061 LKL 1063
Score = 29.6 bits (65), Expect = 5.9
Identities = 42/211 (19%), Positives = 90/211 (42%), Gaps = 23/211 (10%)
Query: 15 KMEVDYSATVDQRLPECAKLAKEGRLQEVIETLLSLEKQTRTASDMVSTSRILVA----- 69
+M + +A + EC++L K+ + ++ TL +EK+ + V +A
Sbjct: 933 EMNAELTAKKRKLEDECSELKKD--IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEI 990
Query: 70 VVKMCYEAK-----------EWDLLNENIMLLSKRRSQLKQAVAKMVQQCCTYVEEITDL 118
+ K+ E K + + + + LSK + +L+Q V + + DL
Sbjct: 991 IAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDL 1050
Query: 119 P-IKLRLIDTLRMVTEGKIYVEIERARLTKTLAT----IKEQNGDVKEAASILQELQVET 173
K +L L++ E + +E ++ +L + L I +QN +++ + +LQ +
Sbjct: 1051 ERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKL 1110
Query: 174 YGSMEKKERVEFILEQMRLCLAVKDYIRTQI 204
+ + E +E LE R A + +R+ +
Sbjct: 1111 KENQARIEELEEELEAERTARAKVEKLRSDL 1141
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 35.8 bits (81), Expect = 0.083
Identities = 88/467 (18%), Positives = 175/467 (37%), Gaps = 54/467 (11%)
Query: 7 ERADGRIVKMEVDYSATVDQRLPECAKLAKE-GRLQEVIETLLSLEKQTRTASDMVSTSR 65
ER +I+++E+++ + + AKE L ++IE +A +S R
Sbjct: 687 ERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEER 746
Query: 66 ILVAVVKMCYEAKEWDLLNENIMLLSKRRSQLKQAVAKMV----QQCCTYVEEITDLPIK 121
++ + KE ++ E R+Q+KQ + Q+ Y + +
Sbjct: 747 D-----QLLSQVKELSMVTE-------LRAQVKQLEMNLAEAERQRRLDYESQTAHDNLL 794
Query: 122 LRLIDTLRMVTEGK-IYVEIERARLTKTLATIKEQNGDVKEAASILQELQVETYGSMEKK 180
I +L + + K + +E+ + L EQ+ ++ S LQ + E E+
Sbjct: 795 TEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERV 854
Query: 181 ERVEFILEQMRLCLAVKDYIRTQ----IISKKINTKFFQEENTEK------LKLKYYNLM 230
+ +E++ L+ K+ T+ ++ KK + + Q+ EK + M
Sbjct: 855 RHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKM 914
Query: 231 IQLDQHEGSYLSICKHYRAIYDTPCIQAESEKWQQALKSVVLYVILAPFDN-------EQ 283
+QL++ + S K + + E++K Q + V + +D +
Sbjct: 915 VQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISK 974
Query: 284 SDLVHRISGDKKLEEIPKYKDLLKLFTTMELM-RWSTLVEDYGMELRKGSLESPATDVFG 342
+L H KK E K K L EL+ R S L E+ + E P ++
Sbjct: 975 EELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETER 1034
Query: 343 STEEGEKRWKDLKNRVVEHNIRIMAKYYTRITMKRMAQLLDLSVDESEAFLSNLVVNKTI 402
E +K K+ + V + + Y + ++ +L + D E
Sbjct: 1035 GEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEE------------ 1082
Query: 403 FAKVDRLAGIINFQR-PKDPNNLLNDWSQKLNSLMSLVNKTTHLIAK 448
+LA FQ K N L D + +++ L + +++ +I K
Sbjct: 1083 -----KLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQK 1124
Score = 30.4 bits (67), Expect = 3.5
Identities = 37/155 (23%), Positives = 75/155 (48%), Gaps = 27/155 (17%)
Query: 158 DVKEAASILQELQV--------ETYGSMEKKERVEFILEQMRLCL--AVKDYIRTQIISK 207
+++ ++S Q L+V ET S + + + + E +R L ++K+ + ++ +
Sbjct: 2990 ELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQ 3049
Query: 208 KINTKFFQ---EENTEKLKLKYYNLMIQLDQ-HEGSYLSICKHYRAIYDTPCIQAESEKW 263
++N+ F Q E+NT ++L + ++ +Q H G L+ C A EK
Sbjct: 3050 QLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHC-------------AVLEKQ 3096
Query: 264 QQALKSVVLYVILAPFDNEQSDLVHRISGDKKLEE 298
Q L++ L + +AP ++ + VHR S ++L E
Sbjct: 3097 VQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELRE 3131
>gi|157738667 FYVE and coiled-coil domain containing 1 [Homo sapiens]
Length = 1478
Score = 35.4 bits (80), Expect = 0.11
Identities = 46/239 (19%), Positives = 102/239 (42%), Gaps = 11/239 (4%)
Query: 4 GGSERADGRIVKMEVDYSATVDQRLPECAKLAKEGRLQEVIETLLSLEKQTRTASDMVST 63
G +R ++V ++ A +D + ++L+ + +TL+ K+ A +
Sbjct: 783 GEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHV 842
Query: 64 SRILVAVVKMCYEAKEWDLLNENIMLLSKRRSQLKQAVAKMVQQCCTYVE---EITDLPI 120
+L C E +E L E +R +L+ ++ Q C+ E E +L
Sbjct: 843 QELL-----QCSE-REGALQEERADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQE 896
Query: 121 KLRLIDTLRMVTEGKIY-VEIERARLTKTLATIKEQNGDVKEAASILQE-LQVETYGSME 178
+L +T ++ + +E+ R+ + LA ++ D KEAAS +E L+ + G +
Sbjct: 897 QLHRANTDTAELGIQVCALTVEKERVEEALACAVQELQDAKEAASREREGLERQVAGLQQ 956
Query: 179 KKERVEFILEQMRLCLAVKDYIRTQIISKKINTKFFQEENTEKLKLKYYNLMIQLDQHE 237
+KE ++ L+ + ++ Q+ + + QE ++L + L ++ ++
Sbjct: 957 EKESLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLSAEIMDYQ 1015
>gi|115511012 coiled-coil domain containing 136 [Homo sapiens]
Length = 1154
Score = 34.7 bits (78), Expect = 0.18
Identities = 42/211 (19%), Positives = 85/211 (40%), Gaps = 22/211 (10%)
Query: 72 KMCYEAKEWDLLNENIMLLSKRRSQLKQAVAKMVQQCCTYVEEITDLPI----------- 120
++C K++D + L K + QL+ + ++ T VE ++ +
Sbjct: 370 RLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKSTLVENQSEKELLCRLQKLHLQH 429
Query: 121 ------KLRLIDTLRMVTEGKIYVEIERARLTKTLATIKEQNGDVKEAASILQELQVETY 174
K +L++ + + E E E L T+A+ KE N E + LQE++
Sbjct: 430 QNVTCEKEKLLERQQQLQEELQCHEAELQHLRDTVASFKESNEKDTETHAQLQEMKQLYQ 489
Query: 175 GSMEKKERVEFILEQMRLCLAVKDYIRTQIISKKINTKFFQEENTEKLKLKYYNLMIQLD 234
S ++ ER + + +Q+ +D + Q+ K++ E+ K K L+ +L
Sbjct: 490 ASKDELERQKHMYDQLE-----QDLLLCQLELKELKASHPIPEDKGKCANKCDTLLSRLT 544
Query: 235 QHEGSYLSICKHYRAIYDTPCIQAESEKWQQ 265
+ + Y + K + C E ++ Q
Sbjct: 545 ELQEKYKASQKEMGQLQMEQCELLEDQRRMQ 575
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 34.3 bits (77), Expect = 0.24
Identities = 45/194 (23%), Positives = 83/194 (42%), Gaps = 25/194 (12%)
Query: 72 KMCYEAKEWDLLNENIMLLSKRRSQLKQAVAKMVQQCCTYVEEITDLPIKLRLIDTLRMV 131
K+ EAK ++ NE + + ++L K+ +C +I DL + L ++ +
Sbjct: 912 KIQLEAKVKEM-NERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHA 970
Query: 132 TEGKI-YVEIERARLTKTLATIKEQNGDVKEA-ASILQELQVE----------------- 172
TE K+ + E A L + +A + ++ ++EA L +LQ E
Sbjct: 971 TENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQ 1030
Query: 173 ---TYGSMEKKERVEFILEQMRLCLAVKDYIRTQIISKKINTKFFQEENTEK--LKLKYY 227
GS+E++++V LE+ + L + + I N K +E +K +L
Sbjct: 1031 VDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNAL 1090
Query: 228 NLMIQLDQHEGSYL 241
N I+ +Q GS L
Sbjct: 1091 NARIEDEQALGSQL 1104
>gi|82880656 coiled-coil domain containing 46 isoform a [Homo
sapiens]
Length = 955
Score = 34.3 bits (77), Expect = 0.24
Identities = 39/175 (22%), Positives = 83/175 (47%), Gaps = 27/175 (15%)
Query: 7 ERADGRIVKMEVDYSATVDQRLPECAKLAKEGRLQEVIETLLSLEKQTRTASDMVSTSRI 66
E+A+ ++ ++E +Y+ KLAK ++ ++T +S K+ + + + R+
Sbjct: 797 EKANSKLKQIEKEYTQ----------KLAKSSQIIAELQTTISSLKEENSQQQLAAERRL 846
Query: 67 LVAVVKMCYEAKEWDLLNENIML-------LSKRRSQLKQAVAKMVQQCCTYVEEITDLP 119
V+ +E ++ L+ +N L R +Q++ A K+ + E+IT
Sbjct: 847 --QDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEKKLQHKELESQEQITY-- 902
Query: 120 IKLRLIDTLRMVTEGKIYVEIERARLTKTLATIKEQNGDVKEAASILQELQVETY 174
I+ L+ + + E+E T++++K Q +++ ASILQE ++ TY
Sbjct: 903 IRQEYETKLKGLMPASLRQELE-----DTISSLKSQVNFLQKRASILQE-ELTTY 951
>gi|64085252 hypothetical protein LOC145508 [Homo sapiens]
Length = 1094
Score = 33.5 bits (75), Expect = 0.41
Identities = 50/210 (23%), Positives = 94/210 (44%), Gaps = 33/210 (15%)
Query: 50 LEKQTRTASDMVSTSRIL---VAVVKMCYEAKEWDLLN--ENIMLLSKRRSQLKQAVAKM 104
L+KQ++ S M L +A +K + LL E+I LS R+ L +A+
Sbjct: 595 LKKQSKIQSQMKVEKAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEE 654
Query: 105 VQQCCTYVEEITDLPIKLRLID--TLRMVTEGKIYVEIERARL---TKTLATIK---EQN 156
+ +++++DL + + D T ++T+ K+ ++ + L T +L ++K EQN
Sbjct: 655 ERAKKAVLKDLSDLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQN 714
Query: 157 ---------GDVKEAASILQELQVETYGSMEKKERVEFILEQMRLCLAVKDYIRTQIISK 207
+ EA + ++ L+ E S+E+K + Q+ + D + ++
Sbjct: 715 IQELMKHFKKEKSEAENHIRTLKAE---SLEEKNMAKIHRGQLEKLKSQCDRLTEELTQN 771
Query: 208 KINTKFFQEENTEKLKLKYYNLMIQLDQHE 237
E +KLKLKY L QL++ E
Sbjct: 772 --------ENENKKLKLKYQCLKDQLEERE 793
>gi|51479166 bicaudal D homolog 2 isoform 1 [Homo sapiens]
Length = 855
Score = 33.1 bits (74), Expect = 0.54
Identities = 62/301 (20%), Positives = 126/301 (41%), Gaps = 36/301 (11%)
Query: 76 EAKEWDLLNEN-------IMLLSKRRSQLKQAVAKMVQQCCTYVEEITDLPIKLRLIDTL 128
E++E L+ E+ + + + +++LKQ + ++ + E + + +L+ I+
Sbjct: 97 ESREESLIQESASKEQYYVRKVLELQTELKQ-LRNVLTNTQSENERLASVAQELKEINQN 155
Query: 129 RMVTEGKIYVEIER-----ARLTKTLATIKEQNGDVKEAASILQELQVETYGSMEK---- 179
+ G++ +I+ ARL + + ++E+N +++ S+L++ QVE G +
Sbjct: 156 VEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRL 215
Query: 180 KERVEFILEQMRLCLAVKDYIRTQIISKKINTKFFQEENTEKLKLKYYNLMIQLDQHEGS 239
+E E++ Q+ + +K+ Q + + + T + E L+ + + M D S
Sbjct: 216 EEETEYLNSQLEDAIRLKEISERQ-LEEALETLKTEREQKNSLRKELSHYMSINDSFYTS 274
Query: 240 YLSICKHYRAIYDTPCIQAESEKWQQALKSVVLYVILA--PFDNEQS------------D 285
+L + D AE +AL + + LA P DN+ S
Sbjct: 275 HLHVSLDGLKFSDD---AAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPS 331
Query: 286 LVHRISGDKKLEEIPKYKDLLKLFTTMELMRWSTLVE-DYGMELRKGSLESPATDVFGST 344
LV + + + EI K K L + +TL + +E +GSL V T
Sbjct: 332 LVSDLLSELNISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLT 391
Query: 345 E 345
E
Sbjct: 392 E 392
>gi|21735417 bicaudal D homolog 2 isoform 2 [Homo sapiens]
Length = 824
Score = 33.1 bits (74), Expect = 0.54
Identities = 62/301 (20%), Positives = 126/301 (41%), Gaps = 36/301 (11%)
Query: 76 EAKEWDLLNEN-------IMLLSKRRSQLKQAVAKMVQQCCTYVEEITDLPIKLRLIDTL 128
E++E L+ E+ + + + +++LKQ + ++ + E + + +L+ I+
Sbjct: 97 ESREESLIQESASKEQYYVRKVLELQTELKQ-LRNVLTNTQSENERLASVAQELKEINQN 155
Query: 129 RMVTEGKIYVEIER-----ARLTKTLATIKEQNGDVKEAASILQELQVETYGSMEK---- 179
+ G++ +I+ ARL + + ++E+N +++ S+L++ QVE G +
Sbjct: 156 VEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRL 215
Query: 180 KERVEFILEQMRLCLAVKDYIRTQIISKKINTKFFQEENTEKLKLKYYNLMIQLDQHEGS 239
+E E++ Q+ + +K+ Q + + + T + E L+ + + M D S
Sbjct: 216 EEETEYLNSQLEDAIRLKEISERQ-LEEALETLKTEREQKNSLRKELSHYMSINDSFYTS 274
Query: 240 YLSICKHYRAIYDTPCIQAESEKWQQALKSVVLYVILA--PFDNEQS------------D 285
+L + D AE +AL + + LA P DN+ S
Sbjct: 275 HLHVSLDGLKFSDD---AAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPS 331
Query: 286 LVHRISGDKKLEEIPKYKDLLKLFTTMELMRWSTLVE-DYGMELRKGSLESPATDVFGST 344
LV + + + EI K K L + +TL + +E +GSL V T
Sbjct: 332 LVSDLLSELNISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLT 391
Query: 345 E 345
E
Sbjct: 392 E 392
>gi|219689136 coiled-coil domain containing 68 [Homo sapiens]
Length = 335
Score = 32.7 bits (73), Expect = 0.70
Identities = 48/222 (21%), Positives = 104/222 (46%), Gaps = 23/222 (10%)
Query: 30 ECAKLAKEGRLQEVIETLL-SLEKQTRTASDMVSTSRILVAVVKMCYEAK---EWDLLNE 85
+ ++ A L+ V + L + + Q+ S+ L+ V K+ E K + LN+
Sbjct: 117 QASREAGAAALRNVAQRLFENYQTQSEEVRKKQEDSKQLLQVNKLEKEQKLKQHVENLNQ 176
Query: 86 NIMLLSKRRSQ---LKQAVAKMVQQCCTYVEEITDLPIKLRLIDTLRMVTEGKIYVEIER 142
L ++ SQ L+ V +M ++ T +E L ++ +L+ T GK +++R
Sbjct: 177 VAEKLEEKHSQITELENLVQRMEKEKRTLLER--KLSLENKLLQLKSSATYGKSCQDLQR 234
Query: 143 A------RLTKTLATIKEQNGDVKEAASILQELQVETYGSMEKKERVEFILEQMRLCLAV 196
+++ I Q+ +++ S++QE++ E+ +R+E + E++ + A
Sbjct: 235 EISILQEQISHLQFVIHSQHQNLR---SVIQEMEGLKNNLKEQDKRIENLREKVNILEAQ 291
Query: 197 KDYIRTQII--SKKINTKFFQEENTEKLK---LKYYNLMIQL 233
++TQ+ S+ TK + +T +LK + Y ++I+L
Sbjct: 292 NKELKTQVALSSETPRTKVSKAVSTSELKTEGVSPYLMLIRL 333
>gi|13376818 coiled-coil domain containing 68 [Homo sapiens]
Length = 335
Score = 32.7 bits (73), Expect = 0.70
Identities = 48/222 (21%), Positives = 104/222 (46%), Gaps = 23/222 (10%)
Query: 30 ECAKLAKEGRLQEVIETLL-SLEKQTRTASDMVSTSRILVAVVKMCYEAK---EWDLLNE 85
+ ++ A L+ V + L + + Q+ S+ L+ V K+ E K + LN+
Sbjct: 117 QASREAGAAALRNVAQRLFENYQTQSEEVRKKQEDSKQLLQVNKLEKEQKLKQHVENLNQ 176
Query: 86 NIMLLSKRRSQ---LKQAVAKMVQQCCTYVEEITDLPIKLRLIDTLRMVTEGKIYVEIER 142
L ++ SQ L+ V +M ++ T +E L ++ +L+ T GK +++R
Sbjct: 177 VAEKLEEKHSQITELENLVQRMEKEKRTLLER--KLSLENKLLQLKSSATYGKSCQDLQR 234
Query: 143 A------RLTKTLATIKEQNGDVKEAASILQELQVETYGSMEKKERVEFILEQMRLCLAV 196
+++ I Q+ +++ S++QE++ E+ +R+E + E++ + A
Sbjct: 235 EISILQEQISHLQFVIHSQHQNLR---SVIQEMEGLKNNLKEQDKRIENLREKVNILEAQ 291
Query: 197 KDYIRTQII--SKKINTKFFQEENTEKLK---LKYYNLMIQL 233
++TQ+ S+ TK + +T +LK + Y ++I+L
Sbjct: 292 NKELKTQVALSSETPRTKVSKAVSTSELKTEGVSPYLMLIRL 333
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 32.7 bits (73), Expect = 0.70
Identities = 40/211 (18%), Positives = 96/211 (45%), Gaps = 16/211 (7%)
Query: 25 DQRLPECAKLAKEGRLQEVIETLLSLEKQTRTASDMVSTSRILVAVVKMCYEAKEWDLLN 84
+Q+L E A+ + R + + E++ + + + + L A+ K +A + ++L
Sbjct: 564 EQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKE--KAAKLEILQ 621
Query: 85 ENIMLLSKRRSQLKQAVAKMVQQCCTYVEEITDLPIKLRLIDTLRM--------VTEGKI 136
+ + + ++ R + +V + ++ ++ +L ++T R V E ++
Sbjct: 622 QQLQVANEARDSAQTSVTQAQREKAELSRKVEELQA---CVETARQEQHEAQAQVAELEL 678
Query: 137 YVEIERARLTKTLATIKEQNGDVKEAASILQELQVETYGSMEK-KERVEFILEQMRLCLA 195
+ E+ + T+ +E++ ++E L+E T GS+E+ K R LE+ + C++
Sbjct: 679 QLRSEQQKATEKERVAQEKD-QLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCIS 737
Query: 196 -VKDYIRTQIISKKINTKFFQEENTEKLKLK 225
+K R+ + K K +EE + L+
Sbjct: 738 ELKAETRSLVEQHKRERKELEEERAGRKGLE 768
>gi|154426264 ubiquitin protein ligase E3 component n-recognin 7
(putative) isoform 3 [Homo sapiens]
Length = 349
Score = 32.7 bits (73), Expect = 0.70
Identities = 26/104 (25%), Positives = 52/104 (50%), Gaps = 12/104 (11%)
Query: 135 KIYVEIERARLTKTLATIK--EQNGDVKEAASILQELQVETYGSMEKKERVEFILEQMRL 192
K+Y +++ LT T+ E G + +A L ++T SM + ++VE I E L
Sbjct: 245 KMYGDLDVLFLTDEYDTVLAYENKGKIAQATDRSDPL-MDTLSSMNRVQQVELICEYNDL 303
Query: 193 CLAVKDYIRT-----QIISKKINTKFFQEENTEKLK----LKYY 227
+KDY++ ++ ++ +FF+E ++K + ++YY
Sbjct: 304 KTELKDYLKRFADEGTVVKREDIQQFFEEFQSKKRRRVDGMQYY 347
>gi|154426322 ubiquitin protein ligase E3 component n-recognin 7
(putative) isoform 2 [Homo sapiens]
Length = 425
Score = 32.7 bits (73), Expect = 0.70
Identities = 26/104 (25%), Positives = 52/104 (50%), Gaps = 12/104 (11%)
Query: 135 KIYVEIERARLTKTLATIK--EQNGDVKEAASILQELQVETYGSMEKKERVEFILEQMRL 192
K+Y +++ LT T+ E G + +A L ++T SM + ++VE I E L
Sbjct: 321 KMYGDLDVLFLTDEYDTVLAYENKGKIAQATDRSDPL-MDTLSSMNRVQQVELICEYNDL 379
Query: 193 CLAVKDYIRT-----QIISKKINTKFFQEENTEKLK----LKYY 227
+KDY++ ++ ++ +FF+E ++K + ++YY
Sbjct: 380 KTELKDYLKRFADEGTVVKREDIQQFFEEFQSKKRRRVDGMQYY 423
>gi|23238222 COP9 constitutive photomorphogenic homolog subunit 3
[Homo sapiens]
Length = 423
Score = 32.7 bits (73), Expect = 0.70
Identities = 21/91 (23%), Positives = 52/91 (57%), Gaps = 4/91 (4%)
Query: 352 KDLKNRVVEHNIRIMAKYYTRITMKRMAQLLDLS-VDESEAFLSNLVVNKTIFAKVDRLA 410
K + + + NI+ + K + ++++ MA + LS E+E ++ +++ + IFA +++
Sbjct: 296 KQCLSSLYKKNIQRLTKTFLTLSLQDMASRVQLSGPQEAEKYVLHMIEDGEIFASINQKD 355
Query: 411 GIINF-QRPKDPNN--LLNDWSQKLNSLMSL 438
G+++F P+ NN +L++ Q++ + L
Sbjct: 356 GMVSFHDNPEKYNNPAMLHNIDQEMLKCIEL 386
>gi|82880654 coiled-coil domain containing 46 isoform b [Homo
sapiens]
Length = 211
Score = 32.7 bits (73), Expect = 0.70
Identities = 38/175 (21%), Positives = 83/175 (47%), Gaps = 27/175 (15%)
Query: 7 ERADGRIVKMEVDYSATVDQRLPECAKLAKEGRLQEVIETLLSLEKQTRTASDMVSTSRI 66
++A+ ++ ++E +Y+ KLAK ++ ++T +S K+ + + + R+
Sbjct: 53 KKANSKLKQIEKEYTQ----------KLAKSSQIIAELQTTISSLKEENSQQQLAAERRL 102
Query: 67 LVAVVKMCYEAKEWDLLNENIML-------LSKRRSQLKQAVAKMVQQCCTYVEEITDLP 119
V+ +E ++ L+ +N L R +Q++ A K+ + E+IT
Sbjct: 103 --QDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEKKLQHKELESQEQITY-- 158
Query: 120 IKLRLIDTLRMVTEGKIYVEIERARLTKTLATIKEQNGDVKEAASILQELQVETY 174
I+ L+ + + E+E T++++K Q +++ ASILQE ++ TY
Sbjct: 159 IRQEYETKLKGLMPASLRQELE-----DTISSLKSQVNFLQKRASILQE-ELTTY 207
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 32.7 bits (73), Expect = 0.70
Identities = 55/241 (22%), Positives = 95/241 (39%), Gaps = 35/241 (14%)
Query: 152 IKEQNGDVKEAASILQELQVETYGSMEKKERVEFILEQMRLCLAVKDYIRTQIISKKINT 211
+KEQ V+ A++LQ E + ++E+ ER I EQ L + + + + INT
Sbjct: 1670 LKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINT 1729
Query: 212 KFFQEENTEKLKLKYYNLMIQLDQHEGSYLSICKHYRAIYDTPCIQAESEKWQQALKSVV 271
K E + +L+ + ++ + E K +AI D + E +K Q S
Sbjct: 1730 KKKLENDVSQLQSEVEEVIQESRNAEE------KAKKAITDAAMMAEELKKEQDT--SAH 1781
Query: 272 LYVILAPFDNEQSDLVHRISGDKKLEEIPKYKDLLKLFTTMELMRWSTLVEDYGMELRKG 331
L + + DL HR+ ++L K + K
Sbjct: 1782 LERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQK------------------------ 1817
Query: 332 SLESPATDVFGSTEEGEKRWKDLKNRVVEHNIRIM-AKYYTRITMKRMAQLLDLSVDESE 390
LE+ ++ G E +KR + + +H R+ Y T K + +L DL VD+ +
Sbjct: 1818 -LEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDL-VDKLQ 1875
Query: 391 A 391
A
Sbjct: 1876 A 1876
Score = 31.6 bits (70), Expect = 1.6
Identities = 34/156 (21%), Positives = 69/156 (44%), Gaps = 12/156 (7%)
Query: 35 AKEGRLQEVIETLLSLEKQTRTASDMVSTSRILVAVVKMCYEAKEWDLLNENIML---LS 91
AK Q+V + SLE++ + D+ R L +K+ E+ D+ N+ L L
Sbjct: 1026 AKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQEST-MDMENDKQQLDEKLE 1084
Query: 92 KRRSQLKQAVAKMVQQCCTYVEEITDLPIKLRLIDTLRMVTEGKIYVEIERARLTKTLAT 151
K+ ++ ++K+ E+ ++ ++ ++ + + E +E ERA K
Sbjct: 1085 KKEFEISNLISKIED------EQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQ 1138
Query: 152 IKEQNGDVKEAASILQELQVETYGSME--KKERVEF 185
+ + +++E + L+E T +E KK EF
Sbjct: 1139 RSDLSRELEEISERLEEAGGATSAQVELNKKREAEF 1174
>gi|7661914 proteasome (prosome, macropain) 26S subunit, non-ATPase,
6 [Homo sapiens]
Length = 389
Score = 32.3 bits (72), Expect = 0.91
Identities = 19/86 (22%), Positives = 40/86 (46%)
Query: 361 HNIRIMAKYYTRITMKRMAQLLDLSVDESEAFLSNLVVNKTIFAKVDRLAGIINFQRPKD 420
H + + Y +T+ MA+ + V+ + LS + + K+D++ I+ RP
Sbjct: 302 HAYSQLLESYRSLTLGYMAEAFGVGVEFIDQELSRFIAAGRLHCKIDKVNEIVETNRPDS 361
Query: 421 PNNLLNDWSQKLNSLMSLVNKTTHLI 446
N + +K + L++ V K + +I
Sbjct: 362 KNWQYQETIKKGDLLLNRVQKLSRVI 387
>gi|45439327 periplakin [Homo sapiens]
Length = 1756
Score = 32.0 bits (71), Expect = 1.2
Identities = 64/296 (21%), Positives = 120/296 (40%), Gaps = 39/296 (13%)
Query: 3 DGGSERADGRIVKMEVDYSATVDQRLP-----ECAKLAKEGRLQEVI---ETLLSLEKQT 54
DGG E ++++E D A D+ L E + K R EV+ + + +L ++
Sbjct: 987 DGGQEYVVKEVLRIEPD-RAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEK 1045
Query: 55 RTASDMVSTSRILVAVVKMCYEAKEWDLLNENIMLLSKRRSQLKQAVAKMVQQCCTYVEE 114
A + V+ ++ EA E+ L E+ +R+ QL++ EE
Sbjct: 1046 SRAQEKVTEKEVVKLQNDPQLEA-EYQQLQED----HQRQDQLREKQE----------EE 1090
Query: 115 ITDLPIKLRLIDTLRMVTEGKIYVEIERARLTKTLATIKEQNGDVKEAASILQELQVETY 174
++ L KL+ ++ R + EGKI V+ E ++ K AT +E V + ++ +
Sbjct: 1091 LSFLQDKLKRLEKERAMAEGKITVK-EVLKVEKDAATERE----VSDLTRQYEDEAAKAR 1145
Query: 175 GSMEKKERVEFILEQMRLCLAVKDYIRTQIISKKINTKFFQEENTEKLKLKYYNLMIQLD 234
S +K E +R A+++ ++ +K+ + E + NL ++L
Sbjct: 1146 ASQREK------TELLRKIWALEEENAKVVVQEKVREIVRPDPKAES---EVANLRLELV 1196
Query: 235 QHEGSYLSICKHYRAIYDTPCIQAESEKWQQALKSVVLYVILAPFDNEQSDLVHRI 290
+ E Y + R+ Y + Q +K V VI D E + R+
Sbjct: 1197 EQERKYRGAEEQLRS-YQSELEALRRRGPQVEVKEVTKEVIKYKTDPEMEKELQRL 1251
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.132 0.365
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,522,237
Number of Sequences: 37866
Number of extensions: 569263
Number of successful extensions: 2089
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 11
Number of HSP's successfully gapped in prelim test: 66
Number of HSP's that attempted gapping in prelim test: 2042
Number of HSP's gapped (non-prelim): 122
length of query: 456
length of database: 18,247,518
effective HSP length: 106
effective length of query: 350
effective length of database: 14,233,722
effective search space: 4981802700
effective search space used: 4981802700
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.