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Search of human proteins with 4506191
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4506191 proteasome beta 10 subunit proprotein [Homo sapiens]
(273 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4506191 proteasome beta 10 subunit proprotein [Homo sapiens] 539 e-153
gi|4506203 proteasome beta 7 subunit proprotein [Homo sapiens] 326 2e-89
gi|23110932 proteasome beta 9 subunit isoform 2 proprotein [Homo... 98 9e-21
gi|4506205 proteasome beta 9 subunit isoform 1 proprotein [Homo ... 98 9e-21
gi|23110925 proteasome beta 6 subunit [Homo sapiens] 97 1e-20
gi|4506201 proteasome beta 5 subunit isoform 1 [Homo sapiens] 80 1e-15
gi|73747875 proteasome beta 8 subunit isoform E2 proprotein [Hom... 80 2e-15
gi|4758970 proteasome beta 8 subunit isoform E1 proprotein [Homo... 80 2e-15
gi|153791216 proteasome beta 11 subunit [Homo sapiens] 76 3e-14
gi|23110942 proteasome alpha 5 subunit [Homo sapiens] 66 4e-11
gi|222144262 proteasome beta 5 subunit isoform 3 [Homo sapiens] 60 2e-09
gi|156713442 proteasome alpha 4 subunit isoform 1 [Homo sapiens] 56 4e-08
gi|4506185 proteasome alpha 4 subunit isoform 1 [Homo sapiens] 56 4e-08
gi|4506189 proteasome alpha 7 subunit [Homo sapiens] 55 7e-08
gi|195539356 proteasome beta 5 subunit isoform 2 [Homo sapiens] 52 6e-07
gi|4506193 proteasome beta 1 subunit [Homo sapiens] 51 1e-06
gi|4506195 proteasome beta 2 subunit [Homo sapiens] 46 3e-05
gi|68303563 proteasome alpha 8 subunit isoform 2 [Homo sapiens] 43 3e-04
gi|156713444 proteasome alpha 4 subunit isoform 2 [Homo sapiens] 42 4e-04
gi|68303561 proteasome alpha 8 subunit isoform 1 [Homo sapiens] 38 0.011
gi|4506181 proteasome subunit alpha type 2 [Homo sapiens] 36 0.032
gi|4506179 proteasome alpha 1 subunit isoform 2 [Homo sapiens] 34 0.16
gi|23110935 proteasome alpha 1 subunit isoform 1 [Homo sapiens] 34 0.16
gi|68303565 proteasome alpha 8 subunit isoform 3 [Homo sapiens] 33 0.20
gi|22538467 proteasome beta 4 subunit [Homo sapiens] 33 0.20
gi|22538465 proteasome beta 3 subunit [Homo sapiens] 33 0.20
gi|23110944 proteasome alpha 6 subunit [Homo sapiens] 31 1.0
>gi|4506191 proteasome beta 10 subunit proprotein [Homo sapiens]
Length = 273
Score = 539 bits (1388), Expect = e-153
Identities = 273/273 (100%), Positives = 273/273 (100%)
Query: 1 MLKPALEPRGGFSFENCQRNASLERVLPGLKVPHARKTGTTIAGLVFQDGVILGADTRAT 60
MLKPALEPRGGFSFENCQRNASLERVLPGLKVPHARKTGTTIAGLVFQDGVILGADTRAT
Sbjct: 1 MLKPALEPRGGFSFENCQRNASLERVLPGLKVPHARKTGTTIAGLVFQDGVILGADTRAT 60
Query: 61 NDSVVADKSCEKIHFIAPKIYCCGAGVAADAEMTTRMVASKMELHALSTGREPRVATVTR 120
NDSVVADKSCEKIHFIAPKIYCCGAGVAADAEMTTRMVASKMELHALSTGREPRVATVTR
Sbjct: 61 NDSVVADKSCEKIHFIAPKIYCCGAGVAADAEMTTRMVASKMELHALSTGREPRVATVTR 120
Query: 121 ILRQTLFRYQGHVGASLIVGGVDLTGPQLYGVHPHGSYSRLPFTALGSGQDAALAVLEDR 180
ILRQTLFRYQGHVGASLIVGGVDLTGPQLYGVHPHGSYSRLPFTALGSGQDAALAVLEDR
Sbjct: 121 ILRQTLFRYQGHVGASLIVGGVDLTGPQLYGVHPHGSYSRLPFTALGSGQDAALAVLEDR 180
Query: 181 FQPNMTLEAAQGLLVEAVTAGILGDLGSGGNVDACVITKTGAKLLRTLSSPTEPVKRSGR 240
FQPNMTLEAAQGLLVEAVTAGILGDLGSGGNVDACVITKTGAKLLRTLSSPTEPVKRSGR
Sbjct: 181 FQPNMTLEAAQGLLVEAVTAGILGDLGSGGNVDACVITKTGAKLLRTLSSPTEPVKRSGR 240
Query: 241 YHFVPGTTAVLTQTVKPLTLELVEETVQAMEVE 273
YHFVPGTTAVLTQTVKPLTLELVEETVQAMEVE
Sbjct: 241 YHFVPGTTAVLTQTVKPLTLELVEETVQAMEVE 273
>gi|4506203 proteasome beta 7 subunit proprotein [Homo sapiens]
Length = 277
Score = 326 bits (835), Expect = 2e-89
Identities = 155/266 (58%), Positives = 202/266 (75%), Gaps = 2/266 (0%)
Query: 8 PRGGFSFENCQRNASLERVLP--GLKVPHARKTGTTIAGLVFQDGVILGADTRATNDSVV 65
P GGFSF+NC+RNA LE G K+P RKTGTTIAG+V++DG++LGADTRAT VV
Sbjct: 10 PVGGFSFDNCRRNAVLEADFAKRGYKLPKVRKTGTTIAGVVYKDGIVLGADTRATEGMVV 69
Query: 66 ADKSCEKIHFIAPKIYCCGAGVAADAEMTTRMVASKMELHALSTGREPRVATVTRILRQT 125
ADK+C KIHFI+P IYCCGAG AAD +MTT++++S +ELH+LSTGR PRV T R+L+Q
Sbjct: 70 ADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLSTGRLPRVVTANRMLKQM 129
Query: 126 LFRYQGHVGASLIVGGVDLTGPQLYGVHPHGSYSRLPFTALGSGQDAALAVLEDRFQPNM 185
LFRYQG++GA+L++GGVD+TGP LY ++PHGS +LP+ +GSG AA+AV ED+F+P+M
Sbjct: 130 LFRYQGYIGAALVLGGVDVTGPHLYSIYPHGSTDKLPYVTMGSGSLAAMAVFEDKFRPDM 189
Query: 186 TLEAAQGLLVEAVTAGILGDLGSGGNVDACVITKTGAKLLRTLSSPTEPVKRSGRYHFVP 245
E A+ L+ EA+ AGI DLGSG N+D CVI+K LR + P + R GRY
Sbjct: 190 EEEEAKNLVSEAIAAGIFNDLGSGSNIDLCVISKNKLDFLRPYTVPNKKGTRLGRYRCEK 249
Query: 246 GTTAVLTQTVKPLTLELVEETVQAME 271
GTTAVLT+ + PL +E++EETVQ M+
Sbjct: 250 GTTAVLTEKITPLEIEVLEETVQTMD 275
>gi|23110932 proteasome beta 9 subunit isoform 2 proprotein [Homo
sapiens]
Length = 209
Score = 97.8 bits (242), Expect = 9e-21
Identities = 57/185 (30%), Positives = 93/185 (50%), Gaps = 2/185 (1%)
Query: 38 TGTTIAGLVFQDGVILGADTRATNDSVVADKSCEKIHFIAPKIYCCGAGVAADAEMTTRM 97
TGTTI + F GV++G+D+R + V ++ +K+ + +IYC +G AADA+ M
Sbjct: 9 TGTTIMAVEFDGGVVMGSDSRVSAGEAVVNRVFDKLSPLHERIYCALSGSAADAQAVADM 68
Query: 98 VASKMELHALSTGREPRVATVTRILRQTLFRYQGHVGASLIVGGVD-LTGPQLYGVHPHG 156
A ++ELH + P V ++R ++Y+ + A L+V G D G Q+YG G
Sbjct: 69 AAYQLELHGIELEEPPLVLAAANVVRNISYKYREDLSAHLMVAGWDQREGGQVYGT-LGG 127
Query: 157 SYSRLPFTALGSGQDAALAVLEDRFQPNMTLEAAQGLLVEAVTAGILGDLGSGGNVDACV 216
+R PF GSG ++ ++P M+ E + +A+ + D SGG +
Sbjct: 128 MLTRQPFAIGGSGSTFIYGYVDAAYKPGMSPEECRRFTTDAIALAMSRDGSSGGVIYLVT 187
Query: 217 ITKTG 221
IT G
Sbjct: 188 ITAAG 192
>gi|4506205 proteasome beta 9 subunit isoform 1 proprotein [Homo
sapiens]
Length = 219
Score = 97.8 bits (242), Expect = 9e-21
Identities = 57/185 (30%), Positives = 93/185 (50%), Gaps = 2/185 (1%)
Query: 38 TGTTIAGLVFQDGVILGADTRATNDSVVADKSCEKIHFIAPKIYCCGAGVAADAEMTTRM 97
TGTTI + F GV++G+D+R + V ++ +K+ + +IYC +G AADA+ M
Sbjct: 19 TGTTIMAVEFDGGVVMGSDSRVSAGEAVVNRVFDKLSPLHERIYCALSGSAADAQAVADM 78
Query: 98 VASKMELHALSTGREPRVATVTRILRQTLFRYQGHVGASLIVGGVD-LTGPQLYGVHPHG 156
A ++ELH + P V ++R ++Y+ + A L+V G D G Q+YG G
Sbjct: 79 AAYQLELHGIELEEPPLVLAAANVVRNISYKYREDLSAHLMVAGWDQREGGQVYGT-LGG 137
Query: 157 SYSRLPFTALGSGQDAALAVLEDRFQPNMTLEAAQGLLVEAVTAGILGDLGSGGNVDACV 216
+R PF GSG ++ ++P M+ E + +A+ + D SGG +
Sbjct: 138 MLTRQPFAIGGSGSTFIYGYVDAAYKPGMSPEECRRFTTDAIALAMSRDGSSGGVIYLVT 197
Query: 217 ITKTG 221
IT G
Sbjct: 198 ITAAG 202
>gi|23110925 proteasome beta 6 subunit [Homo sapiens]
Length = 239
Score = 97.4 bits (241), Expect = 1e-20
Identities = 56/187 (29%), Positives = 91/187 (48%), Gaps = 1/187 (0%)
Query: 38 TGTTIAGLVFQDGVILGADTRATNDSVVADKSCEKIHFIAPKIYCCGAGVAADAEMTTRM 97
TGTTI + F GV+LGAD+R T S +A++ +K+ I +I+CC +G AAD +
Sbjct: 33 TGTTIMAVQFDGGVVLGADSRTTTGSYIANRVTDKLTPIHDRIFCCRSGSAADTQAVADA 92
Query: 98 VASKMELHALSTGREPRVATVTRILRQTLFRYQGHVGASLIVGGVD-LTGPQLYGVHPHG 156
V ++ H++ P V T + ++ +RY+ + A +I+ G D G Q+Y V G
Sbjct: 93 VTYQLGFHSIELNEPPLVHTAASLFKEMCYRYREDLMAGIIIAGWDPQEGGQVYSVPMGG 152
Query: 157 SYSRLPFTALGSGQDAALAVLEDRFQPNMTLEAAQGLLVEAVTAGILGDLGSGGNVDACV 216
R F GSG ++ ++ MT E A+ + D SGG +
Sbjct: 153 MMVRQSFAIGGSGSSYIYGYVDATYREGMTKEECLQFTANALALAMERDGSSGGVIRLAA 212
Query: 217 ITKTGAK 223
I ++G +
Sbjct: 213 IAESGVE 219
>gi|4506201 proteasome beta 5 subunit isoform 1 [Homo sapiens]
Length = 263
Score = 80.5 bits (197), Expect = 1e-15
Identities = 57/196 (29%), Positives = 99/196 (50%), Gaps = 7/196 (3%)
Query: 28 PGLKVPHARKTGTTIAGLVFQDGVILGADTRATNDSVVADKSCEKIHFIAPKIYCCGAGV 87
PG+++ H GTT F+ GVI+ AD+RAT + +A ++ +K+ I P + AG
Sbjct: 52 PGIEMLH----GTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGG 107
Query: 88 AADAEMTTRMVASKMELHALSTGREPRVATVTRILRQTLFRYQGHVGASL--IVGGVDLT 145
AAD R++A + ++ L VA +++L +++Y+G +G S+ ++ G D
Sbjct: 108 AADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKG-MGLSMGTMICGWDKR 166
Query: 146 GPQLYGVHPHGSYSRLPFTALGSGQDAALAVLEDRFQPNMTLEAAQGLLVEAVTAGILGD 205
GP LY V G+ ++GSG A V++ + ++ +E A L A+ D
Sbjct: 167 GPGLYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRD 226
Query: 206 LGSGGNVDACVITKTG 221
SGG V+ + + G
Sbjct: 227 AYSGGAVNLYHVREDG 242
>gi|73747875 proteasome beta 8 subunit isoform E2 proprotein [Homo
sapiens]
Length = 276
Score = 80.1 bits (196), Expect = 2e-15
Identities = 55/177 (31%), Positives = 88/177 (49%), Gaps = 3/177 (1%)
Query: 39 GTTIAGLVFQDGVILGADTRATNDSVVADKSCEKIHFIAPKIYCCGAGVAADAEMTTRMV 98
GTT FQ GVI D+RA+ S ++ K+ I P + +G AAD + R++
Sbjct: 72 GTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGCAADCQYWERLL 131
Query: 99 ASKMELHALSTGREPRVATVTRILRQTLFRYQGHVGASL--IVGGVDLTGPQLYGVHPHG 156
A + L+ L G V+ +++L + +Y+G +G S+ ++ G D GP LY V HG
Sbjct: 132 AKECRLYYLRNGERISVSAASKLLSNMMCQYRG-MGLSMGSMICGWDKKGPGLYYVDEHG 190
Query: 157 SYSRLPFTALGSGQDAALAVLEDRFQPNMTLEAAQGLLVEAVTAGILGDLGSGGNVD 213
+ + GSG A V++ ++PN++ E A L A+ D SGG V+
Sbjct: 191 TRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYDLGRRAIAYATHRDSYSGGVVN 247
>gi|4758970 proteasome beta 8 subunit isoform E1 proprotein [Homo
sapiens]
Length = 272
Score = 80.1 bits (196), Expect = 2e-15
Identities = 55/177 (31%), Positives = 88/177 (49%), Gaps = 3/177 (1%)
Query: 39 GTTIAGLVFQDGVILGADTRATNDSVVADKSCEKIHFIAPKIYCCGAGVAADAEMTTRMV 98
GTT FQ GVI D+RA+ S ++ K+ I P + +G AAD + R++
Sbjct: 68 GTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGCAADCQYWERLL 127
Query: 99 ASKMELHALSTGREPRVATVTRILRQTLFRYQGHVGASL--IVGGVDLTGPQLYGVHPHG 156
A + L+ L G V+ +++L + +Y+G +G S+ ++ G D GP LY V HG
Sbjct: 128 AKECRLYYLRNGERISVSAASKLLSNMMCQYRG-MGLSMGSMICGWDKKGPGLYYVDEHG 186
Query: 157 SYSRLPFTALGSGQDAALAVLEDRFQPNMTLEAAQGLLVEAVTAGILGDLGSGGNVD 213
+ + GSG A V++ ++PN++ E A L A+ D SGG V+
Sbjct: 187 TRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYDLGRRAIAYATHRDSYSGGVVN 243
>gi|153791216 proteasome beta 11 subunit [Homo sapiens]
Length = 300
Score = 76.3 bits (186), Expect = 3e-14
Identities = 61/220 (27%), Positives = 108/220 (49%), Gaps = 8/220 (3%)
Query: 4 PALEPRGGFSF-ENCQRNASLERVLPGLKVPHARKTGTTIAGLVFQDGVILGADTRATND 62
P L GG++ C L+ + G ++ H GTT F+ GVI ADTR++
Sbjct: 19 PHLPRAGGWAVPRGCDPQTFLQ--IHGPRLAH----GTTTLAFRFRHGVIAAADTRSSCG 72
Query: 63 SVVADKSCEKIHFIAPKIYCCGAGVAADAEMTTRMVASKMELHALSTGREPRVATVTRIL 122
S VA + K+ + + +G +AD R++ ++ L L G+ P VA+ ++L
Sbjct: 73 SYVACPASCKVIPVHQHLLGTTSGTSADCATWYRVLQRELRLRELREGQLPSVASAAKLL 132
Query: 123 RQTLFRYQG-HVGASLIVGGVDLTGPQLYGVHPHGSYSRLPFTALGSGQDAALAVLEDRF 181
+ +Y+G + + + G D +GP+L+ V+ G+ + ++GSG A VL+ +
Sbjct: 133 SAMMSQYRGLDLCVATALCGWDRSGPELFYVYSDGTRLQGDIFSVGSGSPYAYGVLDRGY 192
Query: 182 QPNMTLEAAQGLLVEAVTAGILGDLGSGGNVDACVITKTG 221
+ +M+ + A L AV D SGG+VD + ++G
Sbjct: 193 RYDMSTQEAYALARCAVAHATHRDAYSGGSVDLFHVRESG 232
>gi|23110942 proteasome alpha 5 subunit [Homo sapiens]
Length = 241
Score = 65.9 bits (159), Expect = 4e-11
Identities = 46/166 (27%), Positives = 79/166 (47%), Gaps = 11/166 (6%)
Query: 35 ARKTGTTIAGLVFQDGVILGADTRATNDSVVADKSCEKIHFIAPKIYCCGAGVAADAEMT 94
A K G+T G+ +GV L + R T+ ++ S EKI I I C +G+ ADA+
Sbjct: 30 AIKLGSTAIGIQTSEGVCLAVEKRITSP-LMEPSSIEKIVEIDAHIGCAMSGLIADAKTL 88
Query: 95 TRMVASKMELHALSTGREPRVATVTRILRQTLFRYQGH----------VGASLIVGGVDL 144
+ + H + V +VT+ + ++ G +L+ GGVD
Sbjct: 89 IDKARVETQNHWFTYNETMTVESVTQAVSNLALQFGEEDADPGAMSRPFGVALLFGGVDE 148
Query: 145 TGPQLYGVHPHGSYSRLPFTALGSGQDAALAVLEDRFQPNMTLEAA 190
GPQL+ + P G++ + A+GS + A + L++ + +MTL+ A
Sbjct: 149 KGPQLFHMDPSGTFVQCDARAIGSASEGAQSSLQEVYHKSMTLKEA 194
>gi|222144262 proteasome beta 5 subunit isoform 3 [Homo sapiens]
Length = 203
Score = 60.1 bits (144), Expect = 2e-09
Identities = 38/122 (31%), Positives = 67/122 (54%), Gaps = 7/122 (5%)
Query: 28 PGLKVPHARKTGTTIAGLVFQDGVILGADTRATNDSVVADKSCEKIHFIAPKIYCCGAGV 87
PG+++ H GTT F+ GVI+ AD+RAT + +A ++ +K+ I P + AG
Sbjct: 52 PGIEMLH----GTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGG 107
Query: 88 AADAEMTTRMVASKMELHALSTGREPRVATVTRILRQTLFRYQGHVGASL--IVGGVDLT 145
AAD R++A + ++ L VA +++L +++Y+G +G S+ ++ G D
Sbjct: 108 AADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKG-MGLSMGTMICGWDKR 166
Query: 146 GP 147
GP
Sbjct: 167 GP 168
>gi|156713442 proteasome alpha 4 subunit isoform 1 [Homo sapiens]
Length = 261
Score = 55.8 bits (133), Expect = 4e-08
Identities = 50/190 (26%), Positives = 89/190 (46%), Gaps = 7/190 (3%)
Query: 41 TIAGLVFQDGVILGADTRATNDSVVADKSCEKIHFIAPKIYCCGAGVAADAEMTT---RM 97
T G++ DGV+L A+ R + + EKI+ + + C AG+ +DA + T R+
Sbjct: 33 TCLGILANDGVLLAAERRNIHKLLDEVFFSEKIYKLNEDMACSVAGITSDANVLTNELRL 92
Query: 98 VASKMELHALSTGREPRVATVTRILRQTLFRYQGH--VGASLIVGGVDLT-GPQLYGVHP 154
+A + L ++ T ++Q ++ G G SL+ G D G QLY P
Sbjct: 93 IAQRYLLQYQEPIPCEQLVTALCDIKQAYTQFGGKRPFGVSLLYIGWDKHYGFQLYQSDP 152
Query: 155 HGSYSRLPFTALGSGQDAALAVL-EDRFQPNMTLEAAQGLLVEAVTAGILGDLGSGGNVD 213
G+Y T +G+ AA+++L +D + MTL++A L ++ + + S V+
Sbjct: 153 SGNYGGWKATCIGNNSAAAVSMLKQDYKEGEMTLKSALALAIKVLNKTMDVSKLSAEKVE 212
Query: 214 ACVITKTGAK 223
+T+ K
Sbjct: 213 IATLTRENGK 222
>gi|4506185 proteasome alpha 4 subunit isoform 1 [Homo sapiens]
Length = 261
Score = 55.8 bits (133), Expect = 4e-08
Identities = 50/190 (26%), Positives = 89/190 (46%), Gaps = 7/190 (3%)
Query: 41 TIAGLVFQDGVILGADTRATNDSVVADKSCEKIHFIAPKIYCCGAGVAADAEMTT---RM 97
T G++ DGV+L A+ R + + EKI+ + + C AG+ +DA + T R+
Sbjct: 33 TCLGILANDGVLLAAERRNIHKLLDEVFFSEKIYKLNEDMACSVAGITSDANVLTNELRL 92
Query: 98 VASKMELHALSTGREPRVATVTRILRQTLFRYQGH--VGASLIVGGVDLT-GPQLYGVHP 154
+A + L ++ T ++Q ++ G G SL+ G D G QLY P
Sbjct: 93 IAQRYLLQYQEPIPCEQLVTALCDIKQAYTQFGGKRPFGVSLLYIGWDKHYGFQLYQSDP 152
Query: 155 HGSYSRLPFTALGSGQDAALAVL-EDRFQPNMTLEAAQGLLVEAVTAGILGDLGSGGNVD 213
G+Y T +G+ AA+++L +D + MTL++A L ++ + + S V+
Sbjct: 153 SGNYGGWKATCIGNNSAAAVSMLKQDYKEGEMTLKSALALAIKVLNKTMDVSKLSAEKVE 212
Query: 214 ACVITKTGAK 223
+T+ K
Sbjct: 213 IATLTRENGK 222
>gi|4506189 proteasome alpha 7 subunit [Homo sapiens]
Length = 248
Score = 55.1 bits (131), Expect = 7e-08
Identities = 51/194 (26%), Positives = 87/194 (44%), Gaps = 14/194 (7%)
Query: 35 ARKTGTTIAGLVFQDGVILGADTRATNDSVVADKSCEKIHFIAPKIYCCGAGVAADAEMT 94
A K G+T G+ +D V+LG + ++ + +++ KI + + AG+ ADA +
Sbjct: 25 AVKKGSTAVGVRGRDIVVLGVEKKSVA-KLQDERTVRKICALDDNVCMAFAGLTADARIV 83
Query: 95 TRMVASKMELHALSTGREPRVATVTRILRQTLFRY-----QGHVGASLIVGGVDLTG-PQ 148
+ + H L+ V +TR + RY + G S ++ G D G P+
Sbjct: 84 INRARVECQSHRLTVEDPVTVEYITRYIASLKQRYTQSNGRRPFGISALIVGFDFDGTPR 143
Query: 149 LYGVHPHGSYSRLPFTALGSGQDAALAVLEDRFQPNMTLEAAQ--GLLVEAVTAGILGDL 206
LY P G+Y A+G G + LE N T EA + L ++ V +L +
Sbjct: 144 LYQTDPSGTYHAWKANAIGRGAKSVREFLE----KNYTDEAIETDDLTIKLVIKALLEVV 199
Query: 207 GSGG-NVDACVITK 219
SGG N++ V+ +
Sbjct: 200 QSGGKNIELAVMRR 213
>gi|195539356 proteasome beta 5 subunit isoform 2 [Homo sapiens]
Length = 160
Score = 52.0 bits (123), Expect = 6e-07
Identities = 38/139 (27%), Positives = 67/139 (48%), Gaps = 3/139 (2%)
Query: 85 AGVAADAEMTTRMVASKMELHALSTGREPRVATVTRILRQTLFRYQGHVGASL--IVGGV 142
AG AAD R++A + ++ L VA +++L +++Y+G +G S+ ++ G
Sbjct: 2 AGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKG-MGLSMGTMICGW 60
Query: 143 DLTGPQLYGVHPHGSYSRLPFTALGSGQDAALAVLEDRFQPNMTLEAAQGLLVEAVTAGI 202
D GP LY V G+ ++GSG A V++ + ++ +E A L A+
Sbjct: 61 DKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQAT 120
Query: 203 LGDLGSGGNVDACVITKTG 221
D SGG V+ + + G
Sbjct: 121 YRDAYSGGAVNLYHVREDG 139
>gi|4506193 proteasome beta 1 subunit [Homo sapiens]
Length = 241
Score = 50.8 bits (120), Expect = 1e-06
Identities = 42/197 (21%), Positives = 87/197 (44%), Gaps = 13/197 (6%)
Query: 39 GTTIAGLVFQDGVILGADTRATNDSVVADKSCEKIHFIAPKIYCCGAGVAADAEMTTRMV 98
G TI + +D I+ +DTR + + + K + + K +G D T+++
Sbjct: 37 GGTILAIAGEDFAIVASDTRLSEGFSIHTRDSPKCYKLTDKTVIGCSGFHGDCLTLTKII 96
Query: 99 ASKMELHALSTGREPRVATVTRILRQTLF--RYQGHVGASLIVGGVDLTGP-QLYGVHPH 155
++++++ S + + +L L+ R+ + + I+GG+D G +Y P
Sbjct: 97 EARLKMYKHSNNKAMTTGAIAAMLSTILYSRRFFPYYVYN-IIGGLDEEGKGAVYSFDPV 155
Query: 156 GSYSRLPFTALGSGQDAALAVLEDRF---------QPNMTLEAAQGLLVEAVTAGILGDL 206
GSY R F A GS +L+++ ++L+ A L+ + + D+
Sbjct: 156 GSYQRDSFKAGGSASAMLQPLLDNQVGFKNMQNVEHVPLSLDRAMRLVKDVFISAAERDV 215
Query: 207 GSGGNVDACVITKTGAK 223
+G + C++TK G +
Sbjct: 216 YTGDALRICIVTKEGIR 232
>gi|4506195 proteasome beta 2 subunit [Homo sapiens]
Length = 201
Score = 46.2 bits (108), Expect = 3e-05
Identities = 37/157 (23%), Positives = 68/157 (43%), Gaps = 4/157 (2%)
Query: 42 IAGLVFQDGVILGADTRATNDSVVADKSCEKIHFIAPKIYCCGAGVAADAEMTTRMVASK 101
+ G+ D V++ +D A ++ V +K+ ++ KI G A D +
Sbjct: 4 LIGIQGPDYVLVASDRVAASNIVQMKDDHDKMFKMSEKILLLCVGEAGDTVQFAEYIQKN 63
Query: 102 MELHALSTGREPRVATVTRILRQTL---FRYQGHVGASLIVGGVDL-TGPQLYGVHPHGS 157
++L+ + G E R+ L R + +L++ G D GP LY + +
Sbjct: 64 VQLYKMRNGYELSPTAAANFTRRNLADCLRSRTPYHVNLLLAGYDEHEGPALYYMDYLAA 123
Query: 158 YSRLPFTALGSGQDAALAVLEDRFQPNMTLEAAQGLL 194
++ PF A G G L++L+ + P ++ E A LL
Sbjct: 124 LAKAPFAAHGYGAFLTLSILDRYYTPTISRERAVELL 160
>gi|68303563 proteasome alpha 8 subunit isoform 2 [Homo sapiens]
Length = 250
Score = 43.1 bits (100), Expect = 3e-04
Identities = 43/192 (22%), Positives = 80/192 (41%), Gaps = 10/192 (5%)
Query: 35 ARKTGTTIAGLVFQDGVILGADTRATNDSVVADKSCEKIHFIAPKIYCCGAGVAADAEMT 94
A K G+T G+ + V+LG + ++ + +++ KI + + AG+ ADA +
Sbjct: 27 AVKKGSTAVGIRGTNIVVLGVEKKSVA-KLQDERTVRKICALDDHVCMAFAGLTADARVV 85
Query: 95 TRMVASKMELHALSTGREPRVATVTRILRQTLFRYQGHVG------ASLIVGGVDLTGPQ 148
+ + H L+ V +TR + +Y G ++LIVG D +
Sbjct: 86 INRARVECQSHKLTVEDPVTVEYITRFIATLKQKYTQSNGRRPFGISALIVGFDDDGISR 145
Query: 149 LYGVHPHGSYSRLPFTALGSGQDAALAVLEDRFQPNMTLEAAQGLLVEAVTAGILGDLGS 208
LY P G+Y A+G LE + + A+ ++ +L + S
Sbjct: 146 LYQTDPSGTYHAWKANAIGRSAKTVREFLEKNYTEDAI--ASDSEAIKLAIKALLEVVQS 203
Query: 209 GG-NVDACVITK 219
GG N++ +I +
Sbjct: 204 GGKNIELAIIRR 215
>gi|156713444 proteasome alpha 4 subunit isoform 2 [Homo sapiens]
Length = 190
Score = 42.4 bits (98), Expect = 4e-04
Identities = 39/149 (26%), Positives = 69/149 (46%), Gaps = 7/149 (4%)
Query: 82 CCGAGVAADAEMTT---RMVASKMELHALSTGREPRVATVTRILRQTLFRYQGH--VGAS 136
C AG+ +DA + T R++A + L ++ T ++Q ++ G G S
Sbjct: 3 CSVAGITSDANVLTNELRLIAQRYLLQYQEPIPCEQLVTALCDIKQAYTQFGGKRPFGVS 62
Query: 137 LIVGGVDLT-GPQLYGVHPHGSYSRLPFTALGSGQDAALAVL-EDRFQPNMTLEAAQGLL 194
L+ G D G QLY P G+Y T +G+ AA+++L +D + MTL++A L
Sbjct: 63 LLYIGWDKHYGFQLYQSDPSGNYGGWKATCIGNNSAAAVSMLKQDYKEGEMTLKSALALA 122
Query: 195 VEAVTAGILGDLGSGGNVDACVITKTGAK 223
++ + + S V+ +T+ K
Sbjct: 123 IKVLNKTMDVSKLSAEKVEIATLTRENGK 151
>gi|68303561 proteasome alpha 8 subunit isoform 1 [Homo sapiens]
Length = 256
Score = 37.7 bits (86), Expect = 0.011
Identities = 44/197 (22%), Positives = 77/197 (39%), Gaps = 14/197 (7%)
Query: 35 ARKTGTTIAGLVFQDGVILGADTRAT---NDSVVADKSCEKIHFI--APKIYCCGAGVAA 89
A K G+T G+ + V+LG + ++ D K C + A + G+ A
Sbjct: 27 AVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDERTVRKICALDDHVCMAFAVLTIFIGLTA 86
Query: 90 DAEMTTRMVASKMELHALSTGREPRVATVTRILRQTLFRYQGHVG------ASLIVGGVD 143
DA + + + H L+ V +TR + +Y G ++LIVG D
Sbjct: 87 DARVVINRARVECQSHKLTVEDPVTVEYITRFIATLKQKYTQSNGRRPFGISALIVGFDD 146
Query: 144 LTGPQLYGVHPHGSYSRLPFTALGSGQDAALAVLEDRFQPNMTLEAAQGLLVEAVTAGIL 203
+LY P G+Y A+G LE + + A+ ++ +L
Sbjct: 147 DGISRLYQTDPSGTYHAWKANAIGRSAKTVREFLEKNYTEDAI--ASDSEAIKLAIKALL 204
Query: 204 GDLGSGG-NVDACVITK 219
+ SGG N++ +I +
Sbjct: 205 EVVQSGGKNIELAIIRR 221
>gi|4506181 proteasome subunit alpha type 2 [Homo sapiens]
Length = 234
Score = 36.2 bits (82), Expect = 0.032
Identities = 49/207 (23%), Positives = 85/207 (41%), Gaps = 25/207 (12%)
Query: 39 GTTIAGLVFQDGVILGADTRATNDSVVAD-KSCEKIHFIAPKIYCCGAGVAADAEMTTRM 97
G G+ +GV+L + + S++ D +S K+ I I +G+ D +
Sbjct: 32 GAPSVGIKAANGVVLATEKK--QKSILYDERSVHKVEPITKHIGLVYSGMGPDYRVLVHR 89
Query: 98 VASKMELHALSTGREP--------RVATVTRILRQTLFRYQGHV---GASLIVGGVDLTG 146
A K+ +EP RVA+V + Q+ G V G SL++ G +
Sbjct: 90 -ARKLAQQYYLVYQEPIPTAQLVQRVASVMQEYTQS-----GGVRPFGVSLLICGWNEGR 143
Query: 147 PQLYGVHPHGSYSRLPFTALGSGQDAALAVLEDRFQPNMTLEAAQGLLVEAVTAGILGDL 206
P L+ P G+Y TA+G LE R+ ++ LE A + + G +
Sbjct: 144 PYLFQSDPSGAYFAWKATAMGKNYVNGKTFLEKRYNEDLELEDAIHTAILTLKESFEGQM 203
Query: 207 GSGGNVDACVITKTGAKLLRTLSSPTE 233
+ N++ + + G + L +PTE
Sbjct: 204 -TEDNIEVGICNEAGFRRL----TPTE 225
>gi|4506179 proteasome alpha 1 subunit isoform 2 [Homo sapiens]
Length = 263
Score = 33.9 bits (76), Expect = 0.16
Identities = 45/192 (23%), Positives = 73/192 (38%), Gaps = 25/192 (13%)
Query: 35 ARKTGTTIAGLVFQDGVILGADTRATNDSVVADKSCEKIHFIAPKIYCCGAGVAADAEMT 94
A K G+ GL + +L A RA ++ K KI + I AG+ ADA +
Sbjct: 28 AVKQGSATVGLKSKTHAVLVALKRAQSELAAHQK---KILHVDNHIGISIAGLTADARLL 84
Query: 95 TRMVASK-MELHALSTGREPRVATVTRILRQTLFRYQGH----VGASLIVGGVDLTGPQL 149
+ + ++ + P V+ I +T Q + G L++ G D GP +
Sbjct: 85 CNFMRQECLDSRFVFDRPLPVSRLVSLIGSKTQIPTQRYGRRPYGVGLLIAGYDDMGPHI 144
Query: 150 YGVHPHGSYSRLPFTALGSGQDAALAVLEDRFQPNM-----------------TLEAAQG 192
+ P +Y ++G+ +A LE M TL A Q
Sbjct: 145 FQTCPSANYFDCRAMSIGARSQSARTYLERHMSEFMECNLNELVKHGLRALRETLPAEQD 204
Query: 193 LLVEAVTAGILG 204
L + V+ GI+G
Sbjct: 205 LTTKNVSIGIVG 216
>gi|23110935 proteasome alpha 1 subunit isoform 1 [Homo sapiens]
Length = 269
Score = 33.9 bits (76), Expect = 0.16
Identities = 45/192 (23%), Positives = 73/192 (38%), Gaps = 25/192 (13%)
Query: 35 ARKTGTTIAGLVFQDGVILGADTRATNDSVVADKSCEKIHFIAPKIYCCGAGVAADAEMT 94
A K G+ GL + +L A RA ++ K KI + I AG+ ADA +
Sbjct: 34 AVKQGSATVGLKSKTHAVLVALKRAQSELAAHQK---KILHVDNHIGISIAGLTADARLL 90
Query: 95 TRMVASK-MELHALSTGREPRVATVTRILRQTLFRYQGH----VGASLIVGGVDLTGPQL 149
+ + ++ + P V+ I +T Q + G L++ G D GP +
Sbjct: 91 CNFMRQECLDSRFVFDRPLPVSRLVSLIGSKTQIPTQRYGRRPYGVGLLIAGYDDMGPHI 150
Query: 150 YGVHPHGSYSRLPFTALGSGQDAALAVLEDRFQPNM-----------------TLEAAQG 192
+ P +Y ++G+ +A LE M TL A Q
Sbjct: 151 FQTCPSANYFDCRAMSIGARSQSARTYLERHMSEFMECNLNELVKHGLRALRETLPAEQD 210
Query: 193 LLVEAVTAGILG 204
L + V+ GI+G
Sbjct: 211 LTTKNVSIGIVG 222
>gi|68303565 proteasome alpha 8 subunit isoform 3 [Homo sapiens]
Length = 212
Score = 33.5 bits (75), Expect = 0.20
Identities = 32/141 (22%), Positives = 56/141 (39%), Gaps = 9/141 (6%)
Query: 86 GVAADAEMTTRMVASKMELHALSTGREPRVATVTRILRQTLFRYQGHVG------ASLIV 139
G+ ADA + + + H L+ V +TR + +Y G ++LIV
Sbjct: 39 GLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIATLKQKYTQSNGRRPFGISALIV 98
Query: 140 GGVDLTGPQLYGVHPHGSYSRLPFTALGSGQDAALAVLEDRFQPNMTLEAAQGLLVEAVT 199
G D +LY P G+Y A+G LE + + A+ ++
Sbjct: 99 GFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFLEKNYTEDAI--ASDSEAIKLAI 156
Query: 200 AGILGDLGSGG-NVDACVITK 219
+L + SGG N++ +I +
Sbjct: 157 KALLEVVQSGGKNIELAIIRR 177
>gi|22538467 proteasome beta 4 subunit [Homo sapiens]
Length = 264
Score = 33.5 bits (75), Expect = 0.20
Identities = 39/201 (19%), Positives = 80/201 (39%), Gaps = 6/201 (2%)
Query: 38 TGTTIAGLVFQDGVILGADTRATNDSVVADKSCEKIHFIAPKIYCCGAGVAADAEMTTRM 97
TGT++ G+ F+ GV++ AD + S+ ++ +I + +G AD + ++
Sbjct: 52 TGTSVLGVKFEGGVVIAADMLGSYGSLARFRNISRIMRVNNSTMLGASGDYADFQYLKQV 111
Query: 98 VASK-MELHALSTGREPRVATVTRILRQTLFRYQGHVGA---SLIVGGVDLTGPQLYGVH 153
+ ++ L G + L + ++ + + ++++GG L V
Sbjct: 112 LGQMVIDEELLGDGHSYSPRAIHSWLTRAMYSRRSKMNPLWNTMVIGGYADGESFLGYVD 171
Query: 154 PHGSYSRLPFTALGSGQDAALAVLED--RFQPNMTLEAAQGLLVEAVTAGILGDLGSGGN 211
G P A G G A +L + QP ++ A+ L+ + D S
Sbjct: 172 MLGVAYEAPSLATGYGAYLAQPLLREVLEKQPVLSQTEARDLVERCMRVLYYRDARSYNR 231
Query: 212 VDACVITKTGAKLLRTLSSPT 232
+T+ G ++ LS+ T
Sbjct: 232 FQIATVTEKGVEIEGPLSTET 252
>gi|22538465 proteasome beta 3 subunit [Homo sapiens]
Length = 205
Score = 33.5 bits (75), Expect = 0.20
Identities = 36/185 (19%), Positives = 77/185 (41%), Gaps = 4/185 (2%)
Query: 39 GTTIAGLVFQDGVILGADTRATNDSVVADKSCEKIHFIAPKIYCCGAGVAADAEMTTRMV 98
G + + ++ V + AD R + + +KI + ++Y AG+A D + + +
Sbjct: 8 GGAVMAMKGKNCVAIAADRRFGIQAQMVTTDFQKIFPMGDRLYIGLAGLATDVQTVAQRL 67
Query: 99 ASKMELHALSTGREPRVATVTRILRQTLFRYQ-GHVGASLIVGGVD--LTGPQLYGVHPH 155
++ L+ L GR+ + T+ ++ L+ + G ++ G+D P + +
Sbjct: 68 KFRLNLYELKEGRQIKPYTLMSMVANLLYEKRFGPYYTEPVIAGLDPKTFKPFICSLDLI 127
Query: 156 G-SYSRLPFTALGSGQDAALAVLEDRFQPNMTLEAAQGLLVEAVTAGILGDLGSGGNVDA 214
G F G+ + + E ++PNM + + +A+ + D SG V
Sbjct: 128 GCPMVTDDFVVSGTCAEQMYGMCESLWEPNMDPDHLFETISQAMLNAVDRDAVSGMGVIV 187
Query: 215 CVITK 219
+I K
Sbjct: 188 HIIEK 192
>gi|23110944 proteasome alpha 6 subunit [Homo sapiens]
Length = 246
Score = 31.2 bits (69), Expect = 1.0
Identities = 29/127 (22%), Positives = 50/127 (39%), Gaps = 10/127 (7%)
Query: 62 DSVVADKSCEKIHFIAPKIYCCGAGVAADAEMTTRMVASKMELHALSTGRE-------PR 114
D ++ + + I I C G+ AD+ + + G E R
Sbjct: 58 DKLLDSSTVTHLFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKR 117
Query: 115 VATVTRILRQTLFRYQGHVGASLIVGGVDLT-GPQLYGVHPHGSYSRLPFTALGSGQDAA 173
+A ++++ Q +G +I+ G+D GPQ+Y P G Y TA G Q +
Sbjct: 118 IADISQVYTQNA--EMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTES 175
Query: 174 LAVLEDR 180
+ LE +
Sbjct: 176 TSFLEKK 182
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.387
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,627,535
Number of Sequences: 37866
Number of extensions: 393129
Number of successful extensions: 856
Number of sequences better than 10.0: 27
Number of HSP's better than 10.0 without gapping: 15
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 824
Number of HSP's gapped (non-prelim): 27
length of query: 273
length of database: 18,247,518
effective HSP length: 101
effective length of query: 172
effective length of database: 14,423,052
effective search space: 2480764944
effective search space used: 2480764944
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.