Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 4505811
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4505811 non-specific serine/threonine protein kinase [Homo
sapiens]
(313 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4505811 non-specific serine/threonine protein kinase [Homo sa... 647 0.0
gi|224591416 serine/threonine protein kinase pim-3 [Homo sapiens] 437 e-123
gi|42821112 serine/threonine protein kinase pim-2 [Homo sapiens] 337 6e-93
gi|7662170 AMPK-related protein kinase 5 [Homo sapiens] 146 3e-35
gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens] 143 2e-34
gi|38569460 SNF1-like kinase 2 [Homo sapiens] 142 4e-34
gi|35038528 PAS domain containing serine/threonine kinase [Homo ... 140 1e-33
gi|24308326 BR serine/threonine kinase 1 [Homo sapiens] 140 2e-33
gi|116256471 SNF1-like kinase [Homo sapiens] 139 4e-33
gi|116089335 BR serine/threonine kinase 2 [Homo sapiens] 135 6e-32
gi|254028240 MAP/microtubule affinity-regulating kinase 2 isofor... 131 7e-31
gi|254028237 MAP/microtubule affinity-regulating kinase 2 isofor... 131 7e-31
gi|254028234 MAP/microtubule affinity-regulating kinase 2 isofor... 131 7e-31
gi|254028232 MAP/microtubule affinity-regulating kinase 2 isofor... 131 7e-31
gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens] 129 4e-30
gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform... 128 7e-30
gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s... 128 7e-30
gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor... 127 2e-29
gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor... 127 2e-29
gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor... 127 2e-29
gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform... 127 2e-29
gi|156105707 SNF related kinase [Homo sapiens] 126 2e-29
gi|156105705 SNF related kinase [Homo sapiens] 126 2e-29
gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo ... 125 5e-29
gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens] 125 6e-29
gi|194294513 testis-specific serine kinase 2 [Homo sapiens] 122 3e-28
gi|16418343 testis-specific serine kinase 3 [Homo sapiens] 121 7e-28
gi|46877068 AMP-activated protein kinase alpha 2 catalytic subun... 119 3e-27
gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic sub... 115 5e-26
gi|115529463 protein kinase D1 [Homo sapiens] 114 1e-25
>gi|4505811 non-specific serine/threonine protein kinase [Homo
sapiens]
Length = 313
Score = 647 bits (1670), Expect = 0.0
Identities = 313/313 (100%), Positives = 313/313 (100%)
Query: 1 MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSD 60
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSD
Sbjct: 1 MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSD 60
Query: 61 NLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLIL 120
NLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLIL
Sbjct: 61 NLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLIL 120
Query: 121 ERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG 180
ERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG
Sbjct: 121 ERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG 180
Query: 181 ELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI 240
ELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI
Sbjct: 181 ELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI 240
Query: 241 PFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETA 300
PFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETA
Sbjct: 241 PFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETA 300
Query: 301 EIHLHSLSPGPSK 313
EIHLHSLSPGPSK
Sbjct: 301 EIHLHSLSPGPSK 313
>gi|224591416 serine/threonine protein kinase pim-3 [Homo sapiens]
Length = 326
Score = 437 bits (1124), Expect = e-123
Identities = 219/315 (69%), Positives = 254/315 (80%), Gaps = 8/315 (2%)
Query: 1 MLLSKINSLAHLRAAPCNDLHATK-LAPGK-EKEPLESQYQVGPLLGSGGFGSVYSGIRV 58
MLLSK SLAHL D K L P K +KE E YQVG +LGSGGFG+VY+G R+
Sbjct: 1 MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRI 60
Query: 59 SDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSS--GFSGVIRLLDWFERPDSF 116
+D LPVA+KHV K+R+++WG L G VP+EVVLL+KV + G GVIRLLDWFERPD F
Sbjct: 61 ADGLPVAVKHVVKERVTEWGSL-GGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGF 119
Query: 117 VLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILID 176
+L+LERPEP QDLFDFITERGAL E LAR FF QVL AVRHCH+CGV+HRDIKDEN+L+D
Sbjct: 120 LLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVD 179
Query: 177 LNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMV 236
L GELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSA VWSLG+LLYDMV
Sbjct: 180 LRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMV 239
Query: 237 CGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM--QDVL 294
CGDIPFE DEEI+RG++ FR+RVS ECQ LIRWCL+LRPS+RP+ ++I HPWM D
Sbjct: 240 CGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGG 299
Query: 295 LPQETAEIHLHSLSP 309
+P E+ ++ L +L P
Sbjct: 300 VP-ESCDLRLCTLDP 313
>gi|42821112 serine/threonine protein kinase pim-2 [Homo sapiens]
Length = 311
Score = 337 bits (865), Expect = 6e-93
Identities = 167/286 (58%), Positives = 206/286 (72%), Gaps = 5/286 (1%)
Query: 28 GKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVP 87
GK++E E++Y++GPLLG GGFG+V++G R++D L VAIK + ++R+ W L + P
Sbjct: 22 GKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCP 81
Query: 88 MEVVLLKKVSSG--FSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELAR 145
+EV LL KV +G GVIRLLDWFE + F+L+LERP P QDLFD+ITE+G L E +R
Sbjct: 82 LEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSR 141
Query: 146 SFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTR 205
FF QV+ A++HCH+ GV+HRDIKDENILIDL RG KLIDFGSGALL D YTDFDGTR
Sbjct: 142 CFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTR 201
Query: 206 VYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQH 265
VYSPPEWI H+YH A VWSLGILLYDMVCGDIPFE D+EI+ ++ F VS +C
Sbjct: 202 VYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCA 261
Query: 266 LIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGP 311
LIR CLA +PS RP+ EEI PWMQ P E ++ P P
Sbjct: 262 LIRRCLAPKPSSRPSLEEILLDPWMQ---TPAEDVPLNPSKGGPAP 304
>gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]
Length = 661
Score = 146 bits (368), Expect = 3e-35
Identities = 91/266 (34%), Positives = 141/266 (53%), Gaps = 13/266 (4%)
Query: 31 KEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEV 90
K L+ +Y++ LG G +G V VAIK + KD+I D ++ + E+
Sbjct: 48 KHNLKHRYELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDM---VHIRREI 104
Query: 91 VLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQ 150
++ ++ +I + + FE D V+I+E +L+D+I+ER L E R FF Q
Sbjct: 105 EIMSSLNHPH--IISIYEVFENKDKIVIIMEYASK-GELYDYISERRRLSERETRHFFRQ 161
Query: 151 VLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG-SGALLKDTVYTDFDGTRVYSP 209
++ AV +CH GV+HRD+K ENIL+D N +K+ DFG S KD F G+ +Y+
Sbjct: 162 IVSAVHYCHKNGVVHRDLKLENILLDDN-CNIKIADFGLSNLYQKDKFLQTFCGSPLYAS 220
Query: 210 PEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFE-HDEEIIRGQV----FFRQRVSSECQ 264
PE + Y G W+LG+LLY +V G +PF+ D + + Q+ + S+ +
Sbjct: 221 PEIVNGRPYRGPEVDSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQPSDAR 280
Query: 265 HLIRWCLALRPSDRPTFEEIQNHPWM 290
LIRW L + P R T E+I NH W+
Sbjct: 281 GLIRWMLMVNPDRRATIEDIANHWWV 306
>gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens]
Length = 628
Score = 143 bits (360), Expect = 2e-34
Identities = 94/266 (35%), Positives = 143/266 (53%), Gaps = 14/266 (5%)
Query: 31 KEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEV 90
K L +Y+ LG G +G V S L VAIK + KD+I D +L + R E+
Sbjct: 46 KHNLRHRYEFLETLGKGTYGKVKKARESSGRL-VAIKSIRKDKIKDEQDLMHIRR---EI 101
Query: 91 VLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQ 150
++ ++ +I + + FE V+++E DL+D+I+ER L E AR FF Q
Sbjct: 102 EIMSSLNHPH--IIAIHEVFENSSKIVIVMEYASR-GDLYDYISERQQLSEREARHFFRQ 158
Query: 151 VLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTD-FDGTRVYSP 209
++ AV +CH V+HRD+K ENIL+D N G +K+ DFG L + F G+ +Y+
Sbjct: 159 IVSAVHYCHQNRVVHRDLKLENILLDAN-GNIKIADFGLSNLYHQGKFLQTFCGSPLYAS 217
Query: 210 PEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFE-HDEEIIRGQV----FFRQRVSSECQ 264
PE + Y G WSLG+LLY +V G +PF+ HD +I+ Q+ + S+
Sbjct: 218 PEIVNGKPYTGPEVDSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPPKPSDAC 277
Query: 265 HLIRWCLALRPSDRPTFEEIQNHPWM 290
LIRW L + P+ R T E++ +H W+
Sbjct: 278 GLIRWLLMVNPTRRATLEDVASHWWV 303
>gi|38569460 SNF1-like kinase 2 [Homo sapiens]
Length = 926
Score = 142 bits (358), Expect = 4e-34
Identities = 89/275 (32%), Positives = 139/275 (50%), Gaps = 22/275 (8%)
Query: 38 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVS 97
Y + LG G F V G VAIK ++K ++ + N ++ EV ++K +
Sbjct: 20 YDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQL----DAVNLEKIYREVQIMKMLD 75
Query: 98 SGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRH 157
+I+L E L+ E + ++FD++ G L E AR FWQ+L AV +
Sbjct: 76 HPH--IIKLYQVMETKSMLYLVTEYAKN-GEIFDYLANHGRLNESEARRKFWQILSAVDY 132
Query: 158 CHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKD-TVYTDFDGTRVYSPPEWIRYH 216
CH ++HRD+K EN+L+D N +K+ DFG G K + + G+ Y+ PE
Sbjct: 133 CHGRKIVHRDLKAENLLLD-NNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQ 191
Query: 217 RYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQRVSSECQHLIRWC 270
+Y G +WS+G++LY +VCG +PF+ + ++ G+ +S +C+HLIR
Sbjct: 192 QYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRM 251
Query: 271 LALRPSDRPTFEEIQNHPWM-------QDVLLPQE 298
L L PS R T +I+ H WM + VL PQE
Sbjct: 252 LVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQE 286
>gi|35038528 PAS domain containing serine/threonine kinase [Homo
sapiens]
Length = 1323
Score = 140 bits (353), Expect = 1e-33
Identities = 94/269 (34%), Positives = 139/269 (51%), Gaps = 7/269 (2%)
Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISD--WGELPNGTRVPMEVVLLK 94
+Y LGSG FG V++ + N V +K ++K+++ + W E P +V +E+ +L
Sbjct: 998 KYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILS 1057
Query: 95 KVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEA 154
+V + +I++LD FE F L++E+ DLF FI L E LA F Q++ A
Sbjct: 1058 RVEH--ANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSA 1115
Query: 155 VRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL-KDTVYTDFDGTRVYSPPEWI 213
V + ++HRDIKDENI+I +KLIDFGS A L + ++ F GT Y PE +
Sbjct: 1116 VGYLRLKDIIHRDIKDENIVI-AEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVL 1174
Query: 214 RYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLAL 273
+ Y G +WSLG+ LY +V + PF EE + + VS E L+ L
Sbjct: 1175 MGNPYRGPELEMWSLGVTLYTLVFEENPFCELEETVEAAIHPPYLVSKELMSLVSGLLQP 1234
Query: 274 RPSDRPTFEEIQNHPWM-QDVLLPQETAE 301
P R T E++ PW+ Q V L T E
Sbjct: 1235 VPERRTTLEKLVTDPWVTQPVNLADYTWE 1263
>gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]
Length = 778
Score = 140 bits (352), Expect = 2e-33
Identities = 87/269 (32%), Positives = 146/269 (54%), Gaps = 21/269 (7%)
Query: 33 PLESQYQVGPL-----LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVP 87
P +QY VGP LG G G V G+ VAIK V ++++S+ + +V
Sbjct: 25 PQHAQY-VGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESVLM----KVE 79
Query: 88 MEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSF 147
E+ +LK + V++L D +E L+LE +LFD++ ++G L + AR F
Sbjct: 80 REIAILKLIEHPH--VLKLHDVYENKKYLYLVLEHVSG-GELFDYLVKKGRLTPKEARKF 136
Query: 148 FWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGAL-LKDTVYTDFDGTRV 206
F Q++ A+ CH+ + HRD+K EN+L+D + +++ DFG +L + D++ G+
Sbjct: 137 FRQIVSALDFCHSYSICHRDLKPENLLLD-EKNNIRIADFGMASLQVGDSLLETSCGSPH 195
Query: 207 YSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQRVS 260
Y+ PE I+ +Y GR A +WS G++L+ ++ G +PF+ D E++ RG +
Sbjct: 196 YACPEVIKGEKYDGRRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIP 255
Query: 261 SECQHLIRWCLALRPSDRPTFEEIQNHPW 289
+CQ L+R + + P R + E+IQ HPW
Sbjct: 256 PDCQSLLRGMIEVEPEKRLSLEQIQKHPW 284
>gi|116256471 SNF1-like kinase [Homo sapiens]
Length = 783
Score = 139 bits (349), Expect = 4e-33
Identities = 87/271 (32%), Positives = 139/271 (51%), Gaps = 15/271 (5%)
Query: 28 GKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVP 87
G++K Y + LG G F V VAIK ++K R+ N ++
Sbjct: 17 GQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDS----SNLEKIY 72
Query: 88 MEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSF 147
EV L+K ++ +I+L E D ++ E + ++FD++T G L E AR
Sbjct: 73 REVQLMKLLNHPH--IIKLYQVMETKDMLYIVTEFAKN-GEMFDYLTSNGHLSENEARKK 129
Query: 148 FWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKD-TVYTDFDGTRV 206
FWQ+L AV +CH+ ++HRD+K EN+L+D N ++KL DFG G K + + G+
Sbjct: 130 FWQILSAVEYCHDHHIVHRDLKTENLLLDGNM-DIKLADFGFGNFYKSGEPLSTWCGSPP 188
Query: 207 YSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQRVS 260
Y+ PE Y G +WSLG++LY +VCG +PF+ + ++ G+ +S
Sbjct: 189 YAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMS 248
Query: 261 SECQHLIRWCLALRPSDRPTFEEIQNHPWMQ 291
+C+ LIR L + P+ R T +I+ H WM+
Sbjct: 249 QDCESLIRRMLVVDPARRITIAQIRQHRWMR 279
>gi|116089335 BR serine/threonine kinase 2 [Homo sapiens]
Length = 668
Score = 135 bits (339), Expect = 6e-32
Identities = 89/274 (32%), Positives = 146/274 (53%), Gaps = 21/274 (7%)
Query: 28 GKEKEPLESQYQVGPL-----LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPN 82
GK+ +QY VGP LG G G V G+ VAIK V ++++S+ +
Sbjct: 5 GKDGGAQHAQY-VGPYRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVLM-- 61
Query: 83 GTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEE 142
+V E+ +LK + V++L D +E L+LE +LFD++ ++G L +
Sbjct: 62 --KVEREIAILKLIEHPH--VLKLHDVYENKKYLYLVLEHVSG-GELFDYLVKKGRLTPK 116
Query: 143 LARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGAL-LKDTVYTDF 201
AR FF Q++ A+ CH+ + HRD+K EN+L+D + +++ DFG +L + D++
Sbjct: 117 EARKFFRQIISALDFCHSHSICHRDLKPENLLLD-EKNNIRIADFGMASLQVGDSLLETS 175
Query: 202 DGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFF 255
G+ Y+ PE IR +Y GR A VWS G++L+ ++ G +PF+ D E++ RG
Sbjct: 176 CGSPHYACPEVIRGEKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHM 235
Query: 256 RQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPW 289
+ +CQ L+R + + + R T E IQ H W
Sbjct: 236 PHFIPPDCQSLLRGMIEVDAARRLTLEHIQKHIW 269
>gi|254028240 MAP/microtubule affinity-regulating kinase 2 isoform f
[Homo sapiens]
Length = 709
Score = 131 bits (330), Expect = 7e-31
Identities = 83/293 (28%), Positives = 152/293 (51%), Gaps = 18/293 (6%)
Query: 8 SLAHLRAAPC---NDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPV 64
+L HL + P N + A +++P Y++ +G G F V + V
Sbjct: 20 TLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEV 79
Query: 65 AIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPE 124
A+K ++K +++ + ++ EV ++K ++ +++L + E + L++E
Sbjct: 80 AVKIIDKTQLNS----SSLQKLFREVRIMKVLNH--PNIVKLFEVIETEKTLYLVMEYAS 133
Query: 125 PVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKL 184
++FD++ G ++E+ AR+ F Q++ AV++CH ++HRD+K EN+L+D + +K+
Sbjct: 134 G-GEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADM-NIKI 191
Query: 185 IDFG-SGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF- 242
DFG S F G+ Y+ PE + +Y G VWSLG++LY +V G +PF
Sbjct: 192 ADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFD 251
Query: 243 -----EHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM 290
E E ++RG+ +S++C++L++ L L PS R T E+I WM
Sbjct: 252 GQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWM 304
>gi|254028237 MAP/microtubule affinity-regulating kinase 2 isoform e
[Homo sapiens]
Length = 719
Score = 131 bits (330), Expect = 7e-31
Identities = 83/293 (28%), Positives = 152/293 (51%), Gaps = 18/293 (6%)
Query: 8 SLAHLRAAPC---NDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPV 64
+L HL + P N + A +++P Y++ +G G F V + V
Sbjct: 20 TLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEV 79
Query: 65 AIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPE 124
A+K ++K +++ + ++ EV ++K ++ +++L + E + L++E
Sbjct: 80 AVKIIDKTQLNS----SSLQKLFREVRIMKVLNH--PNIVKLFEVIETEKTLYLVMEYAS 133
Query: 125 PVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKL 184
++FD++ G ++E+ AR+ F Q++ AV++CH ++HRD+K EN+L+D + +K+
Sbjct: 134 G-GEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADM-NIKI 191
Query: 185 IDFG-SGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF- 242
DFG S F G+ Y+ PE + +Y G VWSLG++LY +V G +PF
Sbjct: 192 ADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFD 251
Query: 243 -----EHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM 290
E E ++RG+ +S++C++L++ L L PS R T E+I WM
Sbjct: 252 GQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWM 304
>gi|254028234 MAP/microtubule affinity-regulating kinase 2 isoform d
[Homo sapiens]
Length = 788
Score = 131 bits (330), Expect = 7e-31
Identities = 83/293 (28%), Positives = 152/293 (51%), Gaps = 18/293 (6%)
Query: 8 SLAHLRAAPC---NDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPV 64
+L HL + P N + A +++P Y++ +G G F V + V
Sbjct: 20 TLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEV 79
Query: 65 AIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPE 124
A+K ++K +++ + ++ EV ++K ++ +++L + E + L++E
Sbjct: 80 AVKIIDKTQLNS----SSLQKLFREVRIMKVLNH--PNIVKLFEVIETEKTLYLVMEYAS 133
Query: 125 PVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKL 184
++FD++ G ++E+ AR+ F Q++ AV++CH ++HRD+K EN+L+D + +K+
Sbjct: 134 G-GEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADM-NIKI 191
Query: 185 IDFG-SGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF- 242
DFG S F G+ Y+ PE + +Y G VWSLG++LY +V G +PF
Sbjct: 192 ADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFD 251
Query: 243 -----EHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM 290
E E ++RG+ +S++C++L++ L L PS R T E+I WM
Sbjct: 252 GQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWM 304
>gi|254028232 MAP/microtubule affinity-regulating kinase 2 isoform c
[Homo sapiens]
Length = 724
Score = 131 bits (330), Expect = 7e-31
Identities = 83/293 (28%), Positives = 152/293 (51%), Gaps = 18/293 (6%)
Query: 8 SLAHLRAAPC---NDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPV 64
+L HL + P N + A +++P Y++ +G G F V + V
Sbjct: 20 TLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEV 79
Query: 65 AIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPE 124
A+K ++K +++ + ++ EV ++K ++ +++L + E + L++E
Sbjct: 80 AVKIIDKTQLNS----SSLQKLFREVRIMKVLNH--PNIVKLFEVIETEKTLYLVMEYAS 133
Query: 125 PVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKL 184
++FD++ G ++E+ AR+ F Q++ AV++CH ++HRD+K EN+L+D + +K+
Sbjct: 134 G-GEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADM-NIKI 191
Query: 185 IDFG-SGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF- 242
DFG S F G+ Y+ PE + +Y G VWSLG++LY +V G +PF
Sbjct: 192 ADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFD 251
Query: 243 -----EHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM 290
E E ++RG+ +S++C++L++ L L PS R T E+I WM
Sbjct: 252 GQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWM 304
>gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens]
Length = 651
Score = 129 bits (323), Expect = 4e-30
Identities = 94/280 (33%), Positives = 144/280 (51%), Gaps = 19/280 (6%)
Query: 29 KEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM 88
K+ + L Y++ +G+GGF V + VAIK ++K+ + +LP R+
Sbjct: 2 KDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGS--DLP---RIKT 56
Query: 89 EVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFF 148
E+ LK + + +L E + ++LE P +LFD+I + L EE R F
Sbjct: 57 EIEALKNLRH--QHICQLYHVLETANKIFMVLEYC-PGGELFDYIISQDRLSEEETRVVF 113
Query: 149 WQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGAL---LKDTVYTDFDGTR 205
Q++ AV + H+ G HRD+K EN+L D +LKLIDFG A KD G+
Sbjct: 114 RQIVSAVAYVHSQGYAHRDLKPENLLFD-EYHKLKLIDFGLCAKPKGNKDYHLQTCCGSL 172
Query: 206 VYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQRV 259
Y+ PE I+ Y G A VWS+GILLY ++CG +PF+ D ++I+RG+ + +
Sbjct: 173 AYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWL 232
Query: 260 SSECQHLIRWCLALRPSDRPTFEEIQNHPW-MQDVLLPQE 298
S L++ L + P R + + + NHPW MQD P E
Sbjct: 233 SPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVE 272
>gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform a
[Homo sapiens]
Length = 745
Score = 128 bits (321), Expect = 7e-30
Identities = 78/272 (28%), Positives = 144/272 (52%), Gaps = 15/272 (5%)
Query: 26 APGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTR 85
A +++P Y++ +G G F V + VA+K ++K +++ + +
Sbjct: 8 ATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNS----SSLQK 63
Query: 86 VPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELAR 145
+ EV ++K ++ +++L + E + L++E ++FD++ G ++E+ AR
Sbjct: 64 LFREVRIMKVLNH--PNIVKLFEVIETEKTLYLVMEYASG-GEVFDYLVAHGRMKEKEAR 120
Query: 146 SFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG-SGALLKDTVYTDFDGT 204
+ F Q++ AV++CH ++HRD+K EN+L+D + +K+ DFG S F G+
Sbjct: 121 AKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADM-NIKIADFGFSNEFTFGNKLDTFCGS 179
Query: 205 RVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF------EHDEEIIRGQVFFRQR 258
Y+ PE + +Y G VWSLG++LY +V G +PF E E ++RG+
Sbjct: 180 PPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFY 239
Query: 259 VSSECQHLIRWCLALRPSDRPTFEEIQNHPWM 290
+S++C++L++ L L PS R T E+I WM
Sbjct: 240 MSTDCENLLKKFLILNPSKRGTLEQIMKDRWM 271
>gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo
sapiens]
Length = 688
Score = 128 bits (321), Expect = 7e-30
Identities = 77/273 (28%), Positives = 143/273 (52%), Gaps = 15/273 (5%)
Query: 25 LAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGT 84
+A E++P Y++ +G G F V + VAIK ++K +++ +
Sbjct: 46 IASCPEEQPHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNP----SSLQ 101
Query: 85 RVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELA 144
++ EV ++K ++ +++L + E + L++E ++FD++ G ++E+ A
Sbjct: 102 KLFREVRIMKGLNH--PNIVKLFEVIETEKTLYLVMEYAS-AGEVFDYLVSHGRMKEKEA 158
Query: 145 RSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG-SGALLKDTVYTDFDG 203
R+ F Q++ AV +CH ++HRD+K EN+L+D +K+ DFG S + F G
Sbjct: 159 RAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDA-EANIKIADFGFSNEFTLGSKLDTFCG 217
Query: 204 TRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF------EHDEEIIRGQVFFRQ 257
+ Y+ PE + +Y G +WSLG++LY +V G +PF E E ++RG+
Sbjct: 218 SPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPF 277
Query: 258 RVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM 290
+S++C+ ++R L L P+ R T E+I W+
Sbjct: 278 YMSTDCESILRRFLVLNPAKRCTLEQIMKDKWI 310
>gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d
[Homo sapiens]
Length = 713
Score = 127 bits (318), Expect = 2e-29
Identities = 79/273 (28%), Positives = 141/273 (51%), Gaps = 15/273 (5%)
Query: 25 LAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGT 84
+A +++P Y++ +G G F V + VAIK ++K +++ P
Sbjct: 43 IASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLN-----PTSL 97
Query: 85 RVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELA 144
+ V + K+ + +++L + E + LI+E ++FD++ G ++E+ A
Sbjct: 98 QKLFREVRIMKILN-HPNIVKLFEVIETEKTLYLIMEYASG-GEVFDYLVAHGRMKEKEA 155
Query: 145 RSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG-SGALLKDTVYTDFDG 203
RS F Q++ AV++CH ++HRD+K EN+L+D + +K+ DFG S F G
Sbjct: 156 RSKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADM-NIKIADFGFSNEFTVGGKLDTFCG 214
Query: 204 TRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF------EHDEEIIRGQVFFRQ 257
+ Y+ PE + +Y G VWSLG++LY +V G +PF E E ++RG+
Sbjct: 215 SPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPF 274
Query: 258 RVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM 290
+S++C++L++ L L P R T E+I W+
Sbjct: 275 YMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWI 307
>gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b
[Homo sapiens]
Length = 744
Score = 127 bits (318), Expect = 2e-29
Identities = 79/273 (28%), Positives = 141/273 (51%), Gaps = 15/273 (5%)
Query: 25 LAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGT 84
+A +++P Y++ +G G F V + VAIK ++K +++ P
Sbjct: 43 IASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLN-----PTSL 97
Query: 85 RVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELA 144
+ V + K+ + +++L + E + LI+E ++FD++ G ++E+ A
Sbjct: 98 QKLFREVRIMKILN-HPNIVKLFEVIETEKTLYLIMEYASG-GEVFDYLVAHGRMKEKEA 155
Query: 145 RSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG-SGALLKDTVYTDFDG 203
RS F Q++ AV++CH ++HRD+K EN+L+D + +K+ DFG S F G
Sbjct: 156 RSKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADM-NIKIADFGFSNEFTVGGKLDTFCG 214
Query: 204 TRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF------EHDEEIIRGQVFFRQ 257
+ Y+ PE + +Y G VWSLG++LY +V G +PF E E ++RG+
Sbjct: 215 SPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPF 274
Query: 258 RVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM 290
+S++C++L++ L L P R T E+I W+
Sbjct: 275 YMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWI 307
>gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a
[Homo sapiens]
Length = 753
Score = 127 bits (318), Expect = 2e-29
Identities = 79/273 (28%), Positives = 141/273 (51%), Gaps = 15/273 (5%)
Query: 25 LAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGT 84
+A +++P Y++ +G G F V + VAIK ++K +++ P
Sbjct: 43 IASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLN-----PTSL 97
Query: 85 RVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELA 144
+ V + K+ + +++L + E + LI+E ++FD++ G ++E+ A
Sbjct: 98 QKLFREVRIMKILN-HPNIVKLFEVIETEKTLYLIMEYASG-GEVFDYLVAHGRMKEKEA 155
Query: 145 RSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG-SGALLKDTVYTDFDG 203
RS F Q++ AV++CH ++HRD+K EN+L+D + +K+ DFG S F G
Sbjct: 156 RSKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADM-NIKIADFGFSNEFTVGGKLDTFCG 214
Query: 204 TRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF------EHDEEIIRGQVFFRQ 257
+ Y+ PE + +Y G VWSLG++LY +V G +PF E E ++RG+
Sbjct: 215 SPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPF 274
Query: 258 RVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM 290
+S++C++L++ L L P R T E+I W+
Sbjct: 275 YMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWI 307
>gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c
[Homo sapiens]
Length = 729
Score = 127 bits (318), Expect = 2e-29
Identities = 79/273 (28%), Positives = 141/273 (51%), Gaps = 15/273 (5%)
Query: 25 LAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGT 84
+A +++P Y++ +G G F V + VAIK ++K +++ P
Sbjct: 43 IASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLN-----PTSL 97
Query: 85 RVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELA 144
+ V + K+ + +++L + E + LI+E ++FD++ G ++E+ A
Sbjct: 98 QKLFREVRIMKILN-HPNIVKLFEVIETEKTLYLIMEYASG-GEVFDYLVAHGRMKEKEA 155
Query: 145 RSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG-SGALLKDTVYTDFDG 203
RS F Q++ AV++CH ++HRD+K EN+L+D + +K+ DFG S F G
Sbjct: 156 RSKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADM-NIKIADFGFSNEFTVGGKLDTFCG 214
Query: 204 TRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF------EHDEEIIRGQVFFRQ 257
+ Y+ PE + +Y G VWSLG++LY +V G +PF E E ++RG+
Sbjct: 215 SPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPF 274
Query: 258 RVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM 290
+S++C++L++ L L P R T E+I W+
Sbjct: 275 YMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWI 307
>gi|156105707 SNF related kinase [Homo sapiens]
Length = 765
Score = 126 bits (317), Expect = 2e-29
Identities = 88/264 (33%), Positives = 133/264 (50%), Gaps = 15/264 (5%)
Query: 38 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVS 97
Y + LG G F V V VA+K ++K ++ L G + EV +K V
Sbjct: 16 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDT---LATG-HLFQEVRCMKLVQ 71
Query: 98 SGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG-ALQEELARSFFWQVLEAVR 156
++RL + + LILE + D+FD+I + L E+LA+ +F Q++ A+
Sbjct: 72 H--PNIVRLYEVIDTQTKLYLILELGDG-GDMFDYIMKHEEGLNEDLAKKYFAQIVHAIS 128
Query: 157 HCHNCGVLHRDIKDENILIDLNRGELKLIDFG-SGALLKDTVYTDFDGTRVYSPPEWIRY 215
+CH V+HRD+K EN++ +G +KL DFG S T G+ YS PE +
Sbjct: 129 YCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLG 188
Query: 216 HRYHGRSAAVWSLGILLYDMVCGDIPFE--HDEE----IIRGQVFFRQRVSSECQHLIRW 269
Y + +WSLG++L+ +VCG PF+ +D E I+ + VS EC+ LI
Sbjct: 189 DEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITR 248
Query: 270 CLALRPSDRPTFEEIQNHPWMQDV 293
L P R + EEI+NHPW+Q V
Sbjct: 249 MLQRDPKRRASLEEIENHPWLQGV 272
>gi|156105705 SNF related kinase [Homo sapiens]
Length = 765
Score = 126 bits (317), Expect = 2e-29
Identities = 88/264 (33%), Positives = 133/264 (50%), Gaps = 15/264 (5%)
Query: 38 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVS 97
Y + LG G F V V VA+K ++K ++ L G + EV +K V
Sbjct: 16 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDT---LATG-HLFQEVRCMKLVQ 71
Query: 98 SGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG-ALQEELARSFFWQVLEAVR 156
++RL + + LILE + D+FD+I + L E+LA+ +F Q++ A+
Sbjct: 72 H--PNIVRLYEVIDTQTKLYLILELGDG-GDMFDYIMKHEEGLNEDLAKKYFAQIVHAIS 128
Query: 157 HCHNCGVLHRDIKDENILIDLNRGELKLIDFG-SGALLKDTVYTDFDGTRVYSPPEWIRY 215
+CH V+HRD+K EN++ +G +KL DFG S T G+ YS PE +
Sbjct: 129 YCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLG 188
Query: 216 HRYHGRSAAVWSLGILLYDMVCGDIPFE--HDEE----IIRGQVFFRQRVSSECQHLIRW 269
Y + +WSLG++L+ +VCG PF+ +D E I+ + VS EC+ LI
Sbjct: 189 DEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITR 248
Query: 270 CLALRPSDRPTFEEIQNHPWMQDV 293
L P R + EEI+NHPW+Q V
Sbjct: 249 MLQRDPKRRASLEEIENHPWLQGV 272
>gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo
sapiens]
Length = 795
Score = 125 bits (314), Expect = 5e-29
Identities = 76/268 (28%), Positives = 139/268 (51%), Gaps = 15/268 (5%)
Query: 30 EKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPME 89
+++P Y++ +G G F V V VA+K ++K +++ P +
Sbjct: 52 DEQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLN-----PTSLQKLFR 106
Query: 90 VVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFW 149
V + K+ + +++L + E + L++E ++FD++ G ++E+ AR+ F
Sbjct: 107 EVRIMKILN-HPNIVKLFEVIETEKTLYLVMEYASG-GEVFDYLVAHGRMKEKEARAKFR 164
Query: 150 QVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG-SGALLKDTVYTDFDGTRVYS 208
Q++ AV++CH ++HRD+K EN+L+D + +K+ DFG S F G+ Y+
Sbjct: 165 QIVSAVQYCHQKYIVHRDLKAENLLLDGDM-NIKIADFGFSNEFTVGNKLDTFCGSPPYA 223
Query: 209 PPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF------EHDEEIIRGQVFFRQRVSSE 262
PE + +Y G VWSLG++LY +V G +PF E E ++RG+ +S++
Sbjct: 224 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTD 283
Query: 263 CQHLIRWCLALRPSDRPTFEEIQNHPWM 290
C++L++ L L P R + E+I WM
Sbjct: 284 CENLLKKLLVLNPIKRGSLEQIMKDRWM 311
>gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens]
Length = 1263
Score = 125 bits (313), Expect = 6e-29
Identities = 80/261 (30%), Positives = 130/261 (49%), Gaps = 15/261 (5%)
Query: 38 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVS 97
Y++ +G G F V + VAIK ++K ++ + N ++ EV ++K +
Sbjct: 8 YEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDE----ENLKKIFREVQIMKMLC 63
Query: 98 SGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRH 157
+IRL E L+ E ++FD + G + E+ AR F Q++ AV
Sbjct: 64 HPH--IIRLYQVMETERMIYLVTEYASG-GEIFDHLVAHGRMAEKEARRKFKQIVTAVYF 120
Query: 158 CHNCGVLHRDIKDENILIDLNRGELKLIDFG-SGALLKDTVYTDFDGTRVYSPPEWIRYH 216
CH ++HRD+K EN+L+D N +K+ DFG S + + G+ Y+ PE
Sbjct: 121 CHCRNIVHRDLKAENLLLDANL-NIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGK 179
Query: 217 RYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQRVSSECQHLIRWC 270
Y G +WSLG++LY +VCG +PF+ ++ G+ +S+EC+HLIR
Sbjct: 180 EYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHM 239
Query: 271 LALRPSDRPTFEEIQNHPWMQ 291
L L P+ R + E+I H WM+
Sbjct: 240 LVLDPNKRLSMEQICKHKWMK 260
>gi|194294513 testis-specific serine kinase 2 [Homo sapiens]
Length = 358
Score = 122 bits (307), Expect = 3e-28
Identities = 87/269 (32%), Positives = 144/269 (53%), Gaps = 22/269 (8%)
Query: 38 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRI-SDWGELPNGTRVPMEVVLLKKV 96
Y VG LG G + V S VA+K +++ + +D+ E +P E+ +L V
Sbjct: 12 YIVGINLGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVE----RFLPREMDILATV 67
Query: 97 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVR 156
+ G +I+ + FE D + I+ DL +FI +GAL E++AR F Q+ AV+
Sbjct: 68 NHG--SIIKTYEIFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQLSSAVK 125
Query: 157 HCHNCGVLHRDIKDENILIDLNRGELKLIDFG-SGALLKDT-----VYTDFDGTRVYSPP 210
+CH+ ++HRD+K EN+L+D + +KL DFG S L+D+ + F G+ Y+ P
Sbjct: 126 YCHDLDIVHRDLKCENLLLDKD-FNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAAYAAP 184
Query: 211 EWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDE--EIIRGQVFFR------QRVSSE 262
E ++ Y + +WSLG++LY MVCG +P++ + +++R Q R + ++ E
Sbjct: 185 EVLQSIPYQPKVYDIWSLGVILYIMVCGSMPYDDSDIRKMLRIQKEHRVDFPRSKNLTCE 244
Query: 263 CQHLIRWCLALRPSDRPTFEEIQNHPWMQ 291
C+ LI L S R +EI +H W+Q
Sbjct: 245 CKDLIYRMLQPDVSQRLHIDEILSHSWLQ 273
>gi|16418343 testis-specific serine kinase 3 [Homo sapiens]
Length = 268
Score = 121 bits (304), Expect = 7e-28
Identities = 80/269 (29%), Positives = 135/269 (50%), Gaps = 21/269 (7%)
Query: 34 LESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 93
L + YQ+G +G G + V VAIK ++K E +P E+ ++
Sbjct: 6 LSNGYQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDK---MGGPEEFIQRFLPRELQIV 62
Query: 94 KKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLE 153
+ + +I++ + E D + ++ D+FD + G L E A++ F Q++E
Sbjct: 63 RTLDH--KNIIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVE 120
Query: 154 AVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDT---VYTDFDGTRVYSPP 210
A+R+CH CGV HRD+K EN L L LKL DFG +L + + F G+ Y+ P
Sbjct: 121 AIRYCHGCGVAHRDLKCENAL--LQGFNLKLTDFGFAKVLPKSHRELSQTFCGSTAYAAP 178
Query: 211 EWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQR---------VSS 261
E ++ + + VWS+G++LY M+C +PF D+ I ++ +Q+ +S+
Sbjct: 179 EVLQGIPHDSKKGDVWSMGVVLYVMLCASLPF--DDTDIPKMLWQQQKGVSFPTHLSISA 236
Query: 262 ECQHLIRWCLALRPSDRPTFEEIQNHPWM 290
+CQ L++ L RP+ EE+ HPW+
Sbjct: 237 DCQDLLKRLLEPDMILRPSIEEVSWHPWL 265
>gi|46877068 AMP-activated protein kinase alpha 2 catalytic subunit
[Homo sapiens]
Length = 552
Score = 119 bits (298), Expect = 3e-27
Identities = 83/265 (31%), Positives = 132/265 (49%), Gaps = 16/265 (6%)
Query: 38 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVS 97
Y +G LG G FG V G VA+K + + +I L ++ E+ LK
Sbjct: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRS---LDVVGKIKREIQNLKLFR 72
Query: 98 SGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRH 157
+I+L P F +++E +LFD+I + G ++E AR F Q+L AV +
Sbjct: 73 HPH--IIKLYQVISTPTDFFMVMEYVSG-GELFDYICKHGRVEEMEARRLFQQILSAVDY 129
Query: 158 CHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFD-GTRVYSPPEWIRYH 216
CH V+HRD+K EN+L+D + K+ DFG ++ D + G+ Y+ PE I
Sbjct: 130 CHRHMVVHRDLKPENVLLDAHM-NAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGR 188
Query: 217 RYHGRSAAVWSLGILLYDMVCGDIPFEHDEEI------IRGQVFF-RQRVSSECQHLIRW 269
Y G +WS G++LY ++CG +PF+ DE + IRG VF+ + ++ L+
Sbjct: 189 LYAGPEVDIWSCGVILYALLCGTLPFD-DEHVPTLFKKIRGGVFYIPEYLNRSVATLLMH 247
Query: 270 CLALRPSDRPTFEEIQNHPWMQDVL 294
L + P R T ++I+ H W + L
Sbjct: 248 MLQVDPLKRATIKDIREHEWFKQDL 272
>gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic
subunit isoform 1 [Homo sapiens]
Length = 559
Score = 115 bits (288), Expect = 5e-26
Identities = 76/264 (28%), Positives = 126/264 (47%), Gaps = 14/264 (5%)
Query: 38 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVS 97
Y +G LG G FG V G VA+K + + +I + R + L +
Sbjct: 27 YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPH 86
Query: 98 SGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRH 157
+I+L P +++E +LFD+I + G L E+ +R F Q+L V +
Sbjct: 87 -----IIKLYQVISTPSDIFMVMEYVSG-GELFDYICKNGRLDEKESRRLFQQILSGVDY 140
Query: 158 CHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFD-GTRVYSPPEWIRYH 216
CH V+HRD+K EN+L+D + K+ DFG ++ D + G+ Y+ PE I
Sbjct: 141 CHRHMVVHRDLKPENVLLDAHM-NAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGR 199
Query: 217 RYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQRVSSECQHLIRWC 270
Y G +WS G++LY ++CG +PF+ D ++I G + Q ++ L++
Sbjct: 200 LYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHM 259
Query: 271 LALRPSDRPTFEEIQNHPWMQDVL 294
L + P R T ++I+ H W + L
Sbjct: 260 LQVDPMKRATIKDIREHEWFKQDL 283
>gi|115529463 protein kinase D1 [Homo sapiens]
Length = 912
Score = 114 bits (284), Expect = 1e-25
Identities = 85/279 (30%), Positives = 142/279 (50%), Gaps = 24/279 (8%)
Query: 29 KEKEPLESQYQVGP--LLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRV 86
+E + + YQ+ P +LGSG FG VY G VAIK ++K R E +++
Sbjct: 572 QENVDISTVYQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQE----SQL 627
Query: 87 PMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFI--TERGALQEELA 144
EV +L+ + GV+ L FE P+ +++E+ D+ + I +E+G L E +
Sbjct: 628 RNEVAILQNLHH--PGVVNLECMFETPERVFVVMEKLHG--DMLEMILSSEKGRLPEHIT 683
Query: 145 RSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNR--GELKLIDFGSGALLKDTVY-TDF 201
+ Q+L A+RH H ++H D+K EN+L+ ++KL DFG ++ + +
Sbjct: 684 KFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSV 743
Query: 202 DGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEI---IRGQVFFR-- 256
GT Y PE +R Y+ RS +WS+G+++Y + G PF DE+I I+ F
Sbjct: 744 VGTPAYLAPEVLRNKGYN-RSLDMWSVGVIIYVSLSGTFPFNEDEDIHDQIQNAAFMYPP 802
Query: 257 ---QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQD 292
+ +S E LI L ++ R + ++ +HPW+QD
Sbjct: 803 NPWKEISHEAIDLINNLLQVKMRKRYSVDKTLSHPWLQD 841
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.140 0.441
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,449,737
Number of Sequences: 37866
Number of extensions: 617187
Number of successful extensions: 3079
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 484
Number of HSP's successfully gapped in prelim test: 263
Number of HSP's that attempted gapping in prelim test: 1328
Number of HSP's gapped (non-prelim): 915
length of query: 313
length of database: 18,247,518
effective HSP length: 102
effective length of query: 211
effective length of database: 14,385,186
effective search space: 3035274246
effective search space used: 3035274246
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.