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Search of human proteins with 4505579
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4505579 furin preproprotein [Homo sapiens]
(794 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4505579 furin preproprotein [Homo sapiens] 1645 0.0
gi|76443679 proprotein convertase subtilisin/kexin type 4 [Homo ... 782 0.0
gi|20336246 proprotein convertase subtilisin/kexin type 5 prepro... 673 0.0
gi|20336184 paired basic amino acid cleaving system 4 isoform h ... 672 0.0
gi|20336180 paired basic amino acid cleaving system 4 isoform b ... 672 0.0
gi|20336182 paired basic amino acid cleaving system 4 isoform g ... 668 0.0
gi|4505577 paired basic amino acid cleaving system 4 isoform a p... 668 0.0
gi|20336188 paired basic amino acid cleaving system 4 isoform e ... 647 0.0
gi|27894285 paired basic amino acid cleaving system 4 isoform f ... 647 0.0
gi|20336190 paired basic amino acid cleaving system 4 isoform d ... 647 0.0
gi|20336242 proprotein convertase subtilisin/kexin type 1 prepro... 577 e-164
gi|20336186 paired basic amino acid cleaving system 4 isoform c ... 536 e-152
gi|20336244 proprotein convertase subtilisin/kexin type 2 [Homo ... 515 e-146
gi|20336248 proprotein convertase subtilisin/kexin type 7 prepro... 427 e-119
gi|239755070 PREDICTED: similar to proprotein convertase subtili... 54 7e-07
gi|239749596 PREDICTED: hypothetical protein XP_002347099 [Homo ... 54 7e-07
gi|239743863 PREDICTED: hypothetical protein XP_002342982 [Homo ... 53 1e-06
gi|108773804 Fraser syndrome 1 [Homo sapiens] 48 4e-05
gi|222446611 R-spondin family, member 2 [Homo sapiens] 39 0.019
gi|54792100 erbB-3 isoform 1 precursor [Homo sapiens] 36 0.12
gi|18490982 R-spondin 3 [Homo sapiens] 36 0.16
gi|181336739 multiple EGF-like-domains 11 [Homo sapiens] 36 0.16
gi|205360958 cysteine-rich with EGF-like domains 2 isoform b [Ho... 35 0.27
gi|205360956 cysteine-rich with EGF-like domains 2 isoform a [Ho... 35 0.27
gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens] 35 0.36
gi|122937257 thrombospondin, type I, domain containing 7B [Homo ... 35 0.36
gi|4507577 tumor necrosis factor receptor 2 precursor [Homo sapi... 34 0.47
gi|4757836 BRCA1 associated protein-1 [Homo sapiens] 34 0.61
gi|110825958 v-erb-a erythroblastic leukemia viral oncogene homo... 33 0.79
gi|4885215 v-erb-a erythroblastic leukemia viral oncogene homolo... 33 0.79
>gi|4505579 furin preproprotein [Homo sapiens]
Length = 794
Score = 1645 bits (4260), Expect = 0.0
Identities = 794/794 (100%), Positives = 794/794 (100%)
Query: 1 MELRPWLLWVVAATGTLVLLAADAQGQKVFTNTWAVRIPGGPAVANSVARKHGFLNLGQI 60
MELRPWLLWVVAATGTLVLLAADAQGQKVFTNTWAVRIPGGPAVANSVARKHGFLNLGQI
Sbjct: 1 MELRPWLLWVVAATGTLVLLAADAQGQKVFTNTWAVRIPGGPAVANSVARKHGFLNLGQI 60
Query: 61 FGDYYHFWHRGVTKRSLSPHRPRHSRLQREPQVQWLEQQVAKRRTKRDVYQEPTDPKFPQ 120
FGDYYHFWHRGVTKRSLSPHRPRHSRLQREPQVQWLEQQVAKRRTKRDVYQEPTDPKFPQ
Sbjct: 61 FGDYYHFWHRGVTKRSLSPHRPRHSRLQREPQVQWLEQQVAKRRTKRDVYQEPTDPKFPQ 120
Query: 121 QWYLSGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDP 180
QWYLSGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDP
Sbjct: 121 QWYLSGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDP 180
Query: 181 DPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSL 240
DPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSL
Sbjct: 181 DPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSL 240
Query: 241 GLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREH 300
GLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREH
Sbjct: 241 GLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREH 300
Query: 301 DSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKC 360
DSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKC
Sbjct: 301 DSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKC 360
Query: 361 TESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDWATNGVGRKV 420
TESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDWATNGVGRKV
Sbjct: 361 TESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDWATNGVGRKV 420
Query: 421 SHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDIGKRLEVRKTVTACLGEPNH 480
SHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDIGKRLEVRKTVTACLGEPNH
Sbjct: 421 SHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDIGKRLEVRKTVTACLGEPNH 480
Query: 481 ITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWD 540
ITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWD
Sbjct: 481 ITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWD 540
Query: 541 EDPSGEWVLEIENTSEANNYGTLTKFTLVLYGTAPEGLPVPPESSGCKTLTSSQACVVCE 600
EDPSGEWVLEIENTSEANNYGTLTKFTLVLYGTAPEGLPVPPESSGCKTLTSSQACVVCE
Sbjct: 541 EDPSGEWVLEIENTSEANNYGTLTKFTLVLYGTAPEGLPVPPESSGCKTLTSSQACVVCE 600
Query: 601 EGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCAPCHASCATCQGPALTDCL 660
EGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCAPCHASCATCQGPALTDCL
Sbjct: 601 EGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCAPCHASCATCQGPALTDCL 660
Query: 661 SCPSHASLDPVEQTCSRQSQSSRESPPQQQPPRLPPEVEAGQRLRAGLLPSHLPEVVAGL 720
SCPSHASLDPVEQTCSRQSQSSRESPPQQQPPRLPPEVEAGQRLRAGLLPSHLPEVVAGL
Sbjct: 661 SCPSHASLDPVEQTCSRQSQSSRESPPQQQPPRLPPEVEAGQRLRAGLLPSHLPEVVAGL 720
Query: 721 SCAFIVLVFVTVFLVLQLRSGFSFRGVKVYTMDRGLISYKGLPPEAWQEECPSDSEEDEG 780
SCAFIVLVFVTVFLVLQLRSGFSFRGVKVYTMDRGLISYKGLPPEAWQEECPSDSEEDEG
Sbjct: 721 SCAFIVLVFVTVFLVLQLRSGFSFRGVKVYTMDRGLISYKGLPPEAWQEECPSDSEEDEG 780
Query: 781 RGERTAFIKDQSAL 794
RGERTAFIKDQSAL
Sbjct: 781 RGERTAFIKDQSAL 794
>gi|76443679 proprotein convertase subtilisin/kexin type 4 [Homo
sapiens]
Length = 755
Score = 782 bits (2020), Expect = 0.0
Identities = 388/692 (56%), Positives = 476/692 (68%), Gaps = 29/692 (4%)
Query: 29 VFTNTWAVRIPGGPAVANSVARKHGFLNLGQIF--GDYYHFWHRGVTKRSLSPHRPRHSR 86
++ ++WAV++ G +ARK GF+NLG IF G Y+H HRGV ++SL+PH
Sbjct: 33 IYVSSWAVQVSQGNREVERLARKFGFVNLGPIFPDGQYFHLRHRGVVQQSLTPHWGHRLH 92
Query: 87 LQREPQVQWLEQQVAKRRTKRDVYQEPTDPKFPQQWYLSGVTQRDLNVKAAWAQGYTGHG 146
L++ P+VQW +QQ +RR KR V PTDP F +QWY++ Q DL++ AW+QG +G G
Sbjct: 93 LKKNPKVQWFQQQTLQRRVKRSVVV-PTDPWFSKQWYMNSEAQPDLSILQAWSQGLSGQG 151
Query: 147 IVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVA 206
IVVS+LDDGIEK+HPDL NYDP AS+D ND DPDPQPRYT +NRHGTRCAGEVAA+A
Sbjct: 152 IVVSVLDDGIEKDHPDLWANYDPLASYDFNDYDPDPQPRYTPSKENRHGTRCAGEVAAMA 211
Query: 207 NNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGP 266
NNG CGVGVA+NARIGGVRMLDG +TD +EA+SL L P HIHIYSASWGPEDDG+TVDGP
Sbjct: 212 NNGFCGVGVAFNARIGGVRMLDGTITDVIEAQSLSLQPQHIHIYSASWGPEDDGRTVDGP 271
Query: 267 ARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNV 326
L EAF RGV++GRGGLG++F+WASGNGG +D+CNCDGYTNSI+TLS+ S TQ G V
Sbjct: 272 GILTREAFRRGVTKGRGGLGTLFIWASGNGGLHYDNCNCDGYTNSIHTLSVGSTTQQGRV 331
Query: 327 PWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANK 386
PWYSEAC+STL TTYSSG + QIVTTDL CT+ HTGTSASAPLAAG+IAL LEAN
Sbjct: 332 PWYSEACASTLTTTYSSGVATDPQIVTTDLHHGCTDQHTGTSASAPLAAGMIALALEANP 391
Query: 387 NLTWRDMQHLVVQTSKPAHLNANDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAP 446
LTWRDMQHLVV+ SKPAHL A DW TNGVGR+VSH YGYGLLDAG +V A+ W P
Sbjct: 392 FLTWRDMQHLVVRASKPAHLQAEDWRTNGVGRQVSHHYGYGLLDAGLLVDTARTWLPTQP 451
Query: 447 QRKCIIDILTEPKDIGKRLEVRKTVTACLGEPNHITRLEHAQARLTLSYNRRGDLAIHLV 506
QRKC + + + P I + +R+ V+AC G N I LEH QA+LTLSY+RRGDL I L
Sbjct: 452 QRKCAVRVQSRPTPILPLIYIRENVSACAGLHNSIRSLEHVQAQLTLSYSRRGDLEISLT 511
Query: 507 SPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPSGEWVLEIENTSEANNYGTLTKF 566
SPMGTRSTL+A RP D S +G+N+W FM+TH WDE+P G W L +EN N GTL ++
Sbjct: 512 SPMGTRSTLVAIRPLDVSTEGYNNWVFMSTHFWDENPQGVWTLGLENKGYYFNTGTLYRY 571
Query: 567 TLVLYGTAPE--GLPVPPE--SSGCKTLTSSQACVVCEEGFSLHQKSCVQHCPPGFAPQV 622
TL+LYGTA + P P+ SS C + C C+ + + C+ +CPP F
Sbjct: 572 TLLLYGTAEDMTARPTGPQVTSSACVQRDTEGLCQACDGPAYILGQLCLAYCPPRFFNH- 630
Query: 623 LDTHYSTENDVETIRAS--VCAPCHASCATCQGPALTDCLSCPSHASLDPVEQTCSRQSQ 680
T T T + VC+ CHASC TC+G + DC SCP ++LD + +C
Sbjct: 631 --TRLVTAGPGHTAAPALRVCSSCHASCYTCRGGSPRDCTSCPPSSTLDQQQGSCMG--- 685
Query: 681 SSRESPPQQQPPRLPPEVEAGQRLRAGLLPSH 712
P ++ RLRA P H
Sbjct: 686 --------------PTTPDSRPRLRAAACPHH 703
>gi|20336246 proprotein convertase subtilisin/kexin type 5
preproprotein [Homo sapiens]
Length = 913
Score = 673 bits (1736), Expect = 0.0
Identities = 361/724 (49%), Positives = 448/724 (61%), Gaps = 73/724 (10%)
Query: 7 LLWVVAATGTLVLLAADAQGQKVFTNTWAVRIPGGPAVANSVARKHGFLNLGQI--FGDY 64
LL V+A G +L +V+TN WAV+I GG AN +A K+GF+N+GQI DY
Sbjct: 15 LLCVLALLGGCLLPVCRT---RVYTNHWAVKIAGGFPEANRIASKYGFINIGQIGALKDY 71
Query: 65 YHFWHRGVTKRSLSPHRPRHSRLQREPQVQWLEQQVAKRRTKRDVYQEPT------DPKF 118
YHF+H KRS+ R HS + EP+V+W++QQV K+RTKRD DPK+
Sbjct: 72 YHFYHSRTIKRSVISSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDFSRAQSTYFNDPKW 131
Query: 119 PQQWYL-----SGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNYDPGASF 173
P WY+ + Q D+N++ AW +GYTG IVV+ILDDGIE+ HPDL NYD AS
Sbjct: 132 PSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPDLMQNYDALASC 191
Query: 174 DVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTD 233
DVN D DP PRY N+N+HGTRCAGEVAA ANN C VG+A+NA+IGGVRMLDG+VTD
Sbjct: 192 DVNGNDLDPMPRYDASNENKHGTRCAGEVAAAANNSHCTVGIAFNAKIGGVRMLDGDVTD 251
Query: 234 AVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWAS 293
VEA+S+ NP H+HIYSASWGP+DDGKTVDGPA L +AF GV GR GLGS+FVWAS
Sbjct: 252 MVEAKSVSFNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVRMGRRGLGSVFVWAS 311
Query: 294 GNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVT 353
GNGGR D C+CDGYTNSIYT+SISS + G PWY E CSSTLATTYSSG +K+I+T
Sbjct: 312 GNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYSSGESYDKKIIT 371
Query: 354 TDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDWAT 413
TDLRQ+CT++HTGTSASAP+AAGIIAL LEAN LTWRD+QH++V+TS+ HLNANDW T
Sbjct: 372 TDLRQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSRAGHLNANDWKT 431
Query: 414 NGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDIGKRLEVRKTVTA 473
N G KVSH YG+GL+DA AMV A+ WTTV Q C+ + K I VR A
Sbjct: 432 NAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPRQHVCVESTDRQIKTIRPNSAVRSIYKA 491
Query: 474 --CLGEPN-HITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGFND 530
C PN H+ LEH R+T+++ RRGDLAI+L SP GTRS LLA R D+S +GF +
Sbjct: 492 SGCSDNPNRHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANRLFDHSMEGFKN 551
Query: 531 WAFMTTHSWDEDPSGEWVLEIENT-SEANNY---GTLTKFTLVLYGTAPEGL-------- 578
W FMT H W E +G+WVLE+ +T S+ N+ G L +++LVLYGT+ +
Sbjct: 552 WEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSVQPYSPTNEFPK 611
Query: 579 -----------------------PVPPESS--GCKTLTSSQA--CVVCEEGFSLHQKSCV 611
P PE S GC C+ + + CV
Sbjct: 612 VERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCLHYYYKLKNNTRICV 671
Query: 612 QHCPPGFAPQVLDTHYSTENDVETIRASVCAPCHASCATCQGPALTDCLSCPSHASLDPV 671
CPPG HY + C C +C +C G C+SC L+
Sbjct: 672 SSCPPG--------HYHADK-------KRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEE 716
Query: 672 EQTC 675
+C
Sbjct: 717 TNSC 720
Score = 52.8 bits (125), Expect = 1e-06
Identities = 29/85 (34%), Positives = 39/85 (45%), Gaps = 12/85 (14%)
Query: 587 CKTLTSSQA--CVVCEEGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCAPC 644
C T + A C+ C EG+ + CVQ C + +S+EN ++ C C
Sbjct: 789 CATCAGAGADGCINCTEGYFMEDGRCVQSCSISYY-----FDHSSENGYKS-----CKKC 838
Query: 645 HASCATCQGPALTDCLSCPSHASLD 669
SC TC GP +C SCPS LD
Sbjct: 839 DISCLTCNGPGFKNCTSCPSGYLLD 863
Score = 50.1 bits (118), Expect = 8e-06
Identities = 26/79 (32%), Positives = 29/79 (36%), Gaps = 16/79 (20%)
Query: 584 SSGCKTLTSSQACVVCEEGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCAP 643
S CKT T C C +G SL C C G Y D C P
Sbjct: 741 SENCKTCTEFHNCTECRDGLSLQGSRCSVSCEDG--------RYFNGQD--------CQP 784
Query: 644 CHASCATCQGPALTDCLSC 662
CH CATC G C++C
Sbjct: 785 CHRFCATCAGAGADGCINC 803
>gi|20336184 paired basic amino acid cleaving system 4 isoform h
preproprotein [Homo sapiens]
Length = 962
Score = 672 bits (1733), Expect = 0.0
Identities = 363/711 (51%), Positives = 453/711 (63%), Gaps = 55/711 (7%)
Query: 4 RPWLLWVVAATGTLVLLAADAQGQKVFTNTWAVRIPGGPAVANSVARKHGFLNLGQI--F 61
RPW ++ A L + + V+TN WAV++ GGPA A+ VA HG+LNLGQI
Sbjct: 47 RPWRWLLLLA---LPAACSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNL 103
Query: 62 GDYYHFWHRGVTKRSLSPHRPRHSRLQREPQVQWLEQQVAKRRTKRDVYQEP-----TDP 116
DYYHF+H KRS R H+ L+ +PQV+WL+QQ KRR KR V +P DP
Sbjct: 104 EDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDP 163
Query: 117 KFPQQWYL-----SGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNYDPGA 171
+ WYL + + ++NV+AAW +GYTG +VV+ILDDGIE+NHPDLA NYD A
Sbjct: 164 IWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYA 223
Query: 172 SFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEV 231
S+DVN D DP PRY N+N+HGTRCAGEVAA ANN C VG+AYNA+IGG+RMLDG+V
Sbjct: 224 SYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDV 283
Query: 232 TDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVW 291
TD VEA+SLG+ PN+I IYSASWGP+DDGKTVDGP RLA++AF G+ +GR GLGSIFVW
Sbjct: 284 TDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVW 343
Query: 292 ASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQI 351
ASGNGGRE D C+CDGYTNSIYT+S+SSAT+ G PWY E C+STLATTYSSG E++I
Sbjct: 344 ASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKI 403
Query: 352 VTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDW 411
VTTDLRQ+CT+ HTGTS SAP+ AGIIAL LEAN LTWRD+QHL+V+TS+PAHL A+DW
Sbjct: 404 VTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDW 463
Query: 412 ATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDIGKRLEVRKT- 470
NG G KVSH YG+GL+DA A+V A+ WT V Q C+ P+ I +R T
Sbjct: 464 KVNGAGHKVSHFYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTA 523
Query: 471 -VTACLGEPN-HITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGF 528
+AC + + LEH R ++S+ RRGDL I+LVSP GT+S LLA R D S +GF
Sbjct: 524 LTSACAEHSDQRVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGF 583
Query: 529 NDWAFMTTHSWDEDPSGEWVLEIEN-TSEANN---YGTLTKFTLVLYGTAPE-------- 576
+W FMT H W E G+W LEI++ S+ N G L +++L+LYGTA
Sbjct: 584 TNWEFMTVHCWGEKAEGQWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAH 643
Query: 577 -------GLPVPPESSGCKTLTSSQACV-VCEEGFS--LHQKSCVQHCPPGFAPQVLDTH 626
L P L+ SQ V EE ++ H + + C A Q L+
Sbjct: 644 QSRSRMLELSAPELEPPKAALSPSQVEVPEDEEDYTGVCHPECGDKGCDGPNADQCLNCV 703
Query: 627 YSTENDVETIRASV---------------CAPCHASCATCQGPALTDCLSC 662
+ + V+T R V C CH C TC A T CLSC
Sbjct: 704 HFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQCLSC 754
Score = 58.9 bits (141), Expect = 2e-08
Identities = 29/75 (38%), Positives = 37/75 (49%), Gaps = 14/75 (18%)
Query: 588 KTLTSSQACVVCEEGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCAPCHAS 647
K + + C VC+EGFSL + SC+ C PG T D E IR C CH +
Sbjct: 793 KCVDEPEKCTVCKEGFSLARGSCIPDCEPG-----------TYFDSELIR---CGECHHT 838
Query: 648 CATCQGPALTDCLSC 662
C TC GP +C+ C
Sbjct: 839 CGTCVGPGREECIHC 853
Score = 40.8 bits (94), Expect = 0.005
Identities = 25/70 (35%), Positives = 32/70 (45%), Gaps = 18/70 (25%)
Query: 586 GCKTLTSSQA--CVVCEEGFSLHQK--SCVQHCPPGFAPQVLDTHYSTENDVETIRASVC 641
GC+T +S A C+ C GF HQ+ +CV CP GF Y+ E+ C
Sbjct: 739 GCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGF--------YADESQKN------C 784
Query: 642 APCHASCATC 651
CH SC C
Sbjct: 785 LKCHPSCKKC 794
>gi|20336180 paired basic amino acid cleaving system 4 isoform b
preproprotein [Homo sapiens]
Length = 956
Score = 672 bits (1733), Expect = 0.0
Identities = 363/711 (51%), Positives = 453/711 (63%), Gaps = 55/711 (7%)
Query: 4 RPWLLWVVAATGTLVLLAADAQGQKVFTNTWAVRIPGGPAVANSVARKHGFLNLGQI--F 61
RPW ++ A L + + V+TN WAV++ GGPA A+ VA HG+LNLGQI
Sbjct: 47 RPWRWLLLLA---LPAACSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNL 103
Query: 62 GDYYHFWHRGVTKRSLSPHRPRHSRLQREPQVQWLEQQVAKRRTKRDVYQEP-----TDP 116
DYYHF+H KRS R H+ L+ +PQV+WL+QQ KRR KR V +P DP
Sbjct: 104 EDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDP 163
Query: 117 KFPQQWYL-----SGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNYDPGA 171
+ WYL + + ++NV+AAW +GYTG +VV+ILDDGIE+NHPDLA NYD A
Sbjct: 164 IWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYA 223
Query: 172 SFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEV 231
S+DVN D DP PRY N+N+HGTRCAGEVAA ANN C VG+AYNA+IGG+RMLDG+V
Sbjct: 224 SYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDV 283
Query: 232 TDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVW 291
TD VEA+SLG+ PN+I IYSASWGP+DDGKTVDGP RLA++AF G+ +GR GLGSIFVW
Sbjct: 284 TDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVW 343
Query: 292 ASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQI 351
ASGNGGRE D C+CDGYTNSIYT+S+SSAT+ G PWY E C+STLATTYSSG E++I
Sbjct: 344 ASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKI 403
Query: 352 VTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDW 411
VTTDLRQ+CT+ HTGTS SAP+ AGIIAL LEAN LTWRD+QHL+V+TS+PAHL A+DW
Sbjct: 404 VTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDW 463
Query: 412 ATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDIGKRLEVRKT- 470
NG G KVSH YG+GL+DA A+V A+ WT V Q C+ P+ I +R T
Sbjct: 464 KVNGAGHKVSHFYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTA 523
Query: 471 -VTACLGEPN-HITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGF 528
+AC + + LEH R ++S+ RRGDL I+LVSP GT+S LLA R D S +GF
Sbjct: 524 LTSACAEHSDQRVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGF 583
Query: 529 NDWAFMTTHSWDEDPSGEWVLEIEN-TSEANN---YGTLTKFTLVLYGTAPE-------- 576
+W FMT H W E G+W LEI++ S+ N G L +++L+LYGTA
Sbjct: 584 TNWEFMTVHCWGEKAEGQWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAH 643
Query: 577 -------GLPVPPESSGCKTLTSSQACV-VCEEGFS--LHQKSCVQHCPPGFAPQVLDTH 626
L P L+ SQ V EE ++ H + + C A Q L+
Sbjct: 644 QSRSRMLELSAPELEPPKAALSPSQVEVPEDEEDYTGVCHPECGDKGCDGPNADQCLNCV 703
Query: 627 YSTENDVETIRASV---------------CAPCHASCATCQGPALTDCLSC 662
+ + V+T R V C CH C TC A T CLSC
Sbjct: 704 HFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQCLSC 754
Score = 58.9 bits (141), Expect = 2e-08
Identities = 29/75 (38%), Positives = 37/75 (49%), Gaps = 14/75 (18%)
Query: 588 KTLTSSQACVVCEEGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCAPCHAS 647
K + + C VC+EGFSL + SC+ C PG T D E IR C CH +
Sbjct: 793 KCVDEPEKCTVCKEGFSLARGSCIPDCEPG-----------TYFDSELIR---CGECHHT 838
Query: 648 CATCQGPALTDCLSC 662
C TC GP +C+ C
Sbjct: 839 CGTCVGPGREECIHC 853
Score = 40.8 bits (94), Expect = 0.005
Identities = 25/70 (35%), Positives = 32/70 (45%), Gaps = 18/70 (25%)
Query: 586 GCKTLTSSQA--CVVCEEGFSLHQK--SCVQHCPPGFAPQVLDTHYSTENDVETIRASVC 641
GC+T +S A C+ C GF HQ+ +CV CP GF Y+ E+ C
Sbjct: 739 GCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGF--------YADESQKN------C 784
Query: 642 APCHASCATC 651
CH SC C
Sbjct: 785 LKCHPSCKKC 794
Score = 37.4 bits (85), Expect = 0.055
Identities = 18/69 (26%), Positives = 29/69 (42%), Gaps = 11/69 (15%)
Query: 594 QACVVCEEGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCAPCHASCATCQG 653
+ C+ C + F H CV C GF P+ ++ + VC C +C +C G
Sbjct: 848 EECIHCAKNFHFHDWKCVPACGEGFYPE----------EMPGLPHKVCRRCDENCLSCAG 897
Query: 654 PALTDCLSC 662
+ +C C
Sbjct: 898 SS-RNCSRC 905
>gi|20336182 paired basic amino acid cleaving system 4 isoform g
preproprotein [Homo sapiens]
Length = 975
Score = 668 bits (1723), Expect = 0.0
Identities = 362/724 (50%), Positives = 451/724 (62%), Gaps = 68/724 (9%)
Query: 4 RPWLLWVVAATGTLVLLAADAQGQKVFTNTWAVRIPGGPAVANSVARKHGFLNLGQI--F 61
RPW ++ A L + + V+TN WAV++ GGPA A+ VA HG+LNLGQI
Sbjct: 47 RPWRWLLLLA---LPAACSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNL 103
Query: 62 GDYYHFWHRGVTKRSLSPHRPRHSRLQREPQVQWLEQQVAKRRTKRDVYQEP-----TDP 116
DYYHF+H KRS R H+ L+ +PQV+WL+QQ KRR KR V +P DP
Sbjct: 104 EDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDP 163
Query: 117 KFPQQWYL-----SGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNYDPGA 171
+ WYL + + ++NV+AAW +GYTG +VV+ILDDGIE+NHPDLA NYD A
Sbjct: 164 IWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYA 223
Query: 172 SFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEV 231
S+DVN D DP PRY N+N+HGTRCAGEVAA ANN C VG+AYNA+IGG+RMLDG+V
Sbjct: 224 SYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDV 283
Query: 232 TDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVW 291
TD VEA+SLG+ PN+I IYSASWGP+DDGKTVDGP RLA++AF G+ +GR GLGSIFVW
Sbjct: 284 TDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVW 343
Query: 292 ASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQI 351
ASGNGGRE D C+CDGYTNSIYT+S+SSAT+ G PWY E C+STLATTYSSG E++I
Sbjct: 344 ASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKI 403
Query: 352 VTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDW 411
VTTDLRQ+CT+ HTGTS SAP+ AGIIAL LEAN LTWRD+QHL+V+TS+PAHL A+DW
Sbjct: 404 VTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDW 463
Query: 412 ATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDIGKRLEVRKT- 470
NG G KVSH YG+GL+DA A+V A+ WT V Q C+ P+ I +R T
Sbjct: 464 KVNGAGHKVSHFYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTA 523
Query: 471 -VTACLGEPN-HITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGF 528
+AC + + LEH R ++S+ RRGDL I+LVSP GT+S LLA R D S +GF
Sbjct: 524 LTSACAEHSDQRVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGF 583
Query: 529 NDWAFMTTHSWDEDPSGEWVLEIEN-TSEANN---YGTLTKFTLVLYGT----------- 573
+W FMT H W E G+W LEI++ S+ N G L +++L+LYGT
Sbjct: 584 TNWEFMTVHCWGEKAEGQWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAH 643
Query: 574 ----------APEGLPVP----------PESSGCKTLTSSQACVVCEEGFSLHQKSCVQH 613
APE P PE T S+ + H + +
Sbjct: 644 QSRSRMLELSAPELEPPKAALSPSQVEVPEDEEDYTAQSTPGSANILQTSVCHPECGDKG 703
Query: 614 CPPGFAPQVLDTHYSTENDVETIRASV---------------CAPCHASCATCQGPALTD 658
C A Q L+ + + V+T R V C CH C TC A T
Sbjct: 704 CDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQ 763
Query: 659 CLSC 662
CLSC
Sbjct: 764 CLSC 767
Score = 58.9 bits (141), Expect = 2e-08
Identities = 29/75 (38%), Positives = 37/75 (49%), Gaps = 14/75 (18%)
Query: 588 KTLTSSQACVVCEEGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCAPCHAS 647
K + + C VC+EGFSL + SC+ C PG T D E IR C CH +
Sbjct: 806 KCVDEPEKCTVCKEGFSLARGSCIPDCEPG-----------TYFDSELIR---CGECHHT 851
Query: 648 CATCQGPALTDCLSC 662
C TC GP +C+ C
Sbjct: 852 CGTCVGPGREECIHC 866
Score = 40.8 bits (94), Expect = 0.005
Identities = 25/70 (35%), Positives = 32/70 (45%), Gaps = 18/70 (25%)
Query: 586 GCKTLTSSQA--CVVCEEGFSLHQK--SCVQHCPPGFAPQVLDTHYSTENDVETIRASVC 641
GC+T +S A C+ C GF HQ+ +CV CP GF Y+ E+ C
Sbjct: 752 GCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGF--------YADESQKN------C 797
Query: 642 APCHASCATC 651
CH SC C
Sbjct: 798 LKCHPSCKKC 807
>gi|4505577 paired basic amino acid cleaving system 4 isoform a
preproprotein [Homo sapiens]
Length = 969
Score = 668 bits (1723), Expect = 0.0
Identities = 362/724 (50%), Positives = 451/724 (62%), Gaps = 68/724 (9%)
Query: 4 RPWLLWVVAATGTLVLLAADAQGQKVFTNTWAVRIPGGPAVANSVARKHGFLNLGQI--F 61
RPW ++ A L + + V+TN WAV++ GGPA A+ VA HG+LNLGQI
Sbjct: 47 RPWRWLLLLA---LPAACSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNL 103
Query: 62 GDYYHFWHRGVTKRSLSPHRPRHSRLQREPQVQWLEQQVAKRRTKRDVYQEP-----TDP 116
DYYHF+H KRS R H+ L+ +PQV+WL+QQ KRR KR V +P DP
Sbjct: 104 EDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDP 163
Query: 117 KFPQQWYL-----SGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNYDPGA 171
+ WYL + + ++NV+AAW +GYTG +VV+ILDDGIE+NHPDLA NYD A
Sbjct: 164 IWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYA 223
Query: 172 SFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEV 231
S+DVN D DP PRY N+N+HGTRCAGEVAA ANN C VG+AYNA+IGG+RMLDG+V
Sbjct: 224 SYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDV 283
Query: 232 TDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVW 291
TD VEA+SLG+ PN+I IYSASWGP+DDGKTVDGP RLA++AF G+ +GR GLGSIFVW
Sbjct: 284 TDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVW 343
Query: 292 ASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQI 351
ASGNGGRE D C+CDGYTNSIYT+S+SSAT+ G PWY E C+STLATTYSSG E++I
Sbjct: 344 ASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKI 403
Query: 352 VTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDW 411
VTTDLRQ+CT+ HTGTS SAP+ AGIIAL LEAN LTWRD+QHL+V+TS+PAHL A+DW
Sbjct: 404 VTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDW 463
Query: 412 ATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDIGKRLEVRKT- 470
NG G KVSH YG+GL+DA A+V A+ WT V Q C+ P+ I +R T
Sbjct: 464 KVNGAGHKVSHFYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTA 523
Query: 471 -VTACLGEPN-HITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGF 528
+AC + + LEH R ++S+ RRGDL I+LVSP GT+S LLA R D S +GF
Sbjct: 524 LTSACAEHSDQRVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGF 583
Query: 529 NDWAFMTTHSWDEDPSGEWVLEIEN-TSEANN---YGTLTKFTLVLYGT----------- 573
+W FMT H W E G+W LEI++ S+ N G L +++L+LYGT
Sbjct: 584 TNWEFMTVHCWGEKAEGQWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAH 643
Query: 574 ----------APEGLPVP----------PESSGCKTLTSSQACVVCEEGFSLHQKSCVQH 613
APE P PE T S+ + H + +
Sbjct: 644 QSRSRMLELSAPELEPPKAALSPSQVEVPEDEEDYTAQSTPGSANILQTSVCHPECGDKG 703
Query: 614 CPPGFAPQVLDTHYSTENDVETIRASV---------------CAPCHASCATCQGPALTD 658
C A Q L+ + + V+T R V C CH C TC A T
Sbjct: 704 CDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQ 763
Query: 659 CLSC 662
CLSC
Sbjct: 764 CLSC 767
Score = 58.9 bits (141), Expect = 2e-08
Identities = 29/75 (38%), Positives = 37/75 (49%), Gaps = 14/75 (18%)
Query: 588 KTLTSSQACVVCEEGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCAPCHAS 647
K + + C VC+EGFSL + SC+ C PG T D E IR C CH +
Sbjct: 806 KCVDEPEKCTVCKEGFSLARGSCIPDCEPG-----------TYFDSELIR---CGECHHT 851
Query: 648 CATCQGPALTDCLSC 662
C TC GP +C+ C
Sbjct: 852 CGTCVGPGREECIHC 866
Score = 40.8 bits (94), Expect = 0.005
Identities = 25/70 (35%), Positives = 32/70 (45%), Gaps = 18/70 (25%)
Query: 586 GCKTLTSSQA--CVVCEEGFSLHQK--SCVQHCPPGFAPQVLDTHYSTENDVETIRASVC 641
GC+T +S A C+ C GF HQ+ +CV CP GF Y+ E+ C
Sbjct: 752 GCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGF--------YADESQKN------C 797
Query: 642 APCHASCATC 651
CH SC C
Sbjct: 798 LKCHPSCKKC 807
Score = 37.4 bits (85), Expect = 0.055
Identities = 18/69 (26%), Positives = 29/69 (42%), Gaps = 11/69 (15%)
Query: 594 QACVVCEEGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCAPCHASCATCQG 653
+ C+ C + F H CV C GF P+ ++ + VC C +C +C G
Sbjct: 861 EECIHCAKNFHFHDWKCVPACGEGFYPE----------EMPGLPHKVCRRCDENCLSCAG 910
Query: 654 PALTDCLSC 662
+ +C C
Sbjct: 911 SS-RNCSRC 918
>gi|20336188 paired basic amino acid cleaving system 4 isoform e
preproprotein [Homo sapiens]
Length = 623
Score = 647 bits (1668), Expect = 0.0
Identities = 324/565 (57%), Positives = 400/565 (70%), Gaps = 18/565 (3%)
Query: 4 RPWLLWVVAATGTLVLLAADAQGQKVFTNTWAVRIPGGPAVANSVARKHGFLNLGQI--F 61
RPW ++ A L + + V+TN WAV++ GGPA A+ VA HG+LNLGQI
Sbjct: 47 RPWRWLLLLA---LPAACSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNL 103
Query: 62 GDYYHFWHRGVTKRSLSPHRPRHSRLQREPQVQWLEQQVAKRRTKRDVYQEP-----TDP 116
DYYHF+H KRS R H+ L+ +PQV+WL+QQ KRR KR V +P DP
Sbjct: 104 EDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDP 163
Query: 117 KFPQQWYL-----SGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNYDPGA 171
+ WYL + + ++NV+AAW +GYTG +VV+ILDDGIE+NHPDLA NYD A
Sbjct: 164 IWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYA 223
Query: 172 SFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEV 231
S+DVN D DP PRY N+N+HGTRCAGEVAA ANN C VG+AYNA+IGG+RMLDG+V
Sbjct: 224 SYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDV 283
Query: 232 TDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVW 291
TD VEA+SLG+ PN+I IYSASWGP+DDGKTVDGP RLA++AF G+ +GR GLGSIFVW
Sbjct: 284 TDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVW 343
Query: 292 ASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQI 351
ASGNGGRE D C+CDGYTNSIYT+S+SSAT+ G PWY E C+STLATTYSSG E++I
Sbjct: 344 ASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKI 403
Query: 352 VTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDW 411
VTTDLRQ+CT+ HTGTS SAP+ AGIIAL LEAN LTWRD+QHL+V+TS+PAHL A+DW
Sbjct: 404 VTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDW 463
Query: 412 ATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDIGKRLEVRKT- 470
NG G KVSH YG+GL+DA A+V A+ WT V Q C+ P+ I +R T
Sbjct: 464 KVNGAGHKVSHFYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTA 523
Query: 471 -VTACLGEPN-HITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGF 528
+AC + + LEH R ++S+ RRGDL I+LVSP GT+S LLA R D S +GF
Sbjct: 524 LTSACAEHSDQRVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGF 583
Query: 529 NDWAFMTTHSWDEDPSGEWVLEIEN 553
+W FMT H W E G+W LEI++
Sbjct: 584 TNWEFMTVHCWGEKAEGQWTLEIQD 608
>gi|27894285 paired basic amino acid cleaving system 4 isoform f
preproprotein [Homo sapiens]
Length = 664
Score = 647 bits (1668), Expect = 0.0
Identities = 324/565 (57%), Positives = 400/565 (70%), Gaps = 18/565 (3%)
Query: 4 RPWLLWVVAATGTLVLLAADAQGQKVFTNTWAVRIPGGPAVANSVARKHGFLNLGQI--F 61
RPW ++ A L + + V+TN WAV++ GGPA A+ VA HG+LNLGQI
Sbjct: 47 RPWRWLLLLA---LPAACSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNL 103
Query: 62 GDYYHFWHRGVTKRSLSPHRPRHSRLQREPQVQWLEQQVAKRRTKRDVYQEP-----TDP 116
DYYHF+H KRS R H+ L+ +PQV+WL+QQ KRR KR V +P DP
Sbjct: 104 EDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDP 163
Query: 117 KFPQQWYL-----SGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNYDPGA 171
+ WYL + + ++NV+AAW +GYTG +VV+ILDDGIE+NHPDLA NYD A
Sbjct: 164 IWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYA 223
Query: 172 SFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEV 231
S+DVN D DP PRY N+N+HGTRCAGEVAA ANN C VG+AYNA+IGG+RMLDG+V
Sbjct: 224 SYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDV 283
Query: 232 TDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVW 291
TD VEA+SLG+ PN+I IYSASWGP+DDGKTVDGP RLA++AF G+ +GR GLGSIFVW
Sbjct: 284 TDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVW 343
Query: 292 ASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQI 351
ASGNGGRE D C+CDGYTNSIYT+S+SSAT+ G PWY E C+STLATTYSSG E++I
Sbjct: 344 ASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKI 403
Query: 352 VTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDW 411
VTTDLRQ+CT+ HTGTS SAP+ AGIIAL LEAN LTWRD+QHL+V+TS+PAHL A+DW
Sbjct: 404 VTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDW 463
Query: 412 ATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDIGKRLEVRKT- 470
NG G KVSH YG+GL+DA A+V A+ WT V Q C+ P+ I +R T
Sbjct: 464 KVNGAGHKVSHFYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTA 523
Query: 471 -VTACLGEPN-HITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGF 528
+AC + + LEH R ++S+ RRGDL I+LVSP GT+S LLA R D S +GF
Sbjct: 524 LTSACAEHSDQRVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGF 583
Query: 529 NDWAFMTTHSWDEDPSGEWVLEIEN 553
+W FMT H W E G+W LEI++
Sbjct: 584 TNWEFMTVHCWGEKAEGQWTLEIQD 608
>gi|20336190 paired basic amino acid cleaving system 4 isoform d
preproprotein [Homo sapiens]
Length = 652
Score = 647 bits (1668), Expect = 0.0
Identities = 324/565 (57%), Positives = 400/565 (70%), Gaps = 18/565 (3%)
Query: 4 RPWLLWVVAATGTLVLLAADAQGQKVFTNTWAVRIPGGPAVANSVARKHGFLNLGQI--F 61
RPW ++ A L + + V+TN WAV++ GGPA A+ VA HG+LNLGQI
Sbjct: 47 RPWRWLLLLA---LPAACSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNL 103
Query: 62 GDYYHFWHRGVTKRSLSPHRPRHSRLQREPQVQWLEQQVAKRRTKRDVYQEP-----TDP 116
DYYHF+H KRS R H+ L+ +PQV+WL+QQ KRR KR V +P DP
Sbjct: 104 EDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDP 163
Query: 117 KFPQQWYL-----SGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNYDPGA 171
+ WYL + + ++NV+AAW +GYTG +VV+ILDDGIE+NHPDLA NYD A
Sbjct: 164 IWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYA 223
Query: 172 SFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEV 231
S+DVN D DP PRY N+N+HGTRCAGEVAA ANN C VG+AYNA+IGG+RMLDG+V
Sbjct: 224 SYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDV 283
Query: 232 TDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVW 291
TD VEA+SLG+ PN+I IYSASWGP+DDGKTVDGP RLA++AF G+ +GR GLGSIFVW
Sbjct: 284 TDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVW 343
Query: 292 ASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQI 351
ASGNGGRE D C+CDGYTNSIYT+S+SSAT+ G PWY E C+STLATTYSSG E++I
Sbjct: 344 ASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKI 403
Query: 352 VTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDW 411
VTTDLRQ+CT+ HTGTS SAP+ AGIIAL LEAN LTWRD+QHL+V+TS+PAHL A+DW
Sbjct: 404 VTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDW 463
Query: 412 ATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDIGKRLEVRKT- 470
NG G KVSH YG+GL+DA A+V A+ WT V Q C+ P+ I +R T
Sbjct: 464 KVNGAGHKVSHFYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTA 523
Query: 471 -VTACLGEPN-HITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGF 528
+AC + + LEH R ++S+ RRGDL I+LVSP GT+S LLA R D S +GF
Sbjct: 524 LTSACAEHSDQRVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGF 583
Query: 529 NDWAFMTTHSWDEDPSGEWVLEIEN 553
+W FMT H W E G+W LEI++
Sbjct: 584 TNWEFMTVHCWGEKAEGQWTLEIQD 608
>gi|20336242 proprotein convertase subtilisin/kexin type 1
preproprotein [Homo sapiens]
Length = 753
Score = 577 bits (1487), Expect = e-164
Identities = 307/608 (50%), Positives = 396/608 (65%), Gaps = 31/608 (5%)
Query: 1 MELRPWLLWVVAATGTLVLLAA-----DAQGQKVFTNTWAVRIPGGPAVANSVARKHGFL 55
ME R W L A VL A A+ ++ F N WA IPGGP A+++A + G+
Sbjct: 1 MERRAWSLQCTA----FVLFCAWCALNSAKAKRQFVNEWAAEIPGGPEAASAIAEELGYD 56
Query: 56 NLGQI--FGDYYHFWHRGVTKRSLSPHRPRHSRLQREPQVQWLEQQVAKRRTKRDVYQEP 113
LGQI ++Y F H+ +RS RL + +V W EQQ K R+KR ++
Sbjct: 57 LLGQIGSLENHYLFKHKNHPRRSRRSAFHITKRLSDDDRVIWAEQQYEKERSKRSALRDS 116
Query: 114 T-----DPKFPQQWYL------SGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNHPD 162
DP + QQWYL + + + DL+V W +G TG G+V+++LDDG+E NH D
Sbjct: 117 ALNLFNDPMWNQQWYLQDTRMTAALPKLDLHVIPVWQKGITGKGVVITVLDDGLEWNHTD 176
Query: 163 LAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIG 222
+ NYDP AS+D ND D DP PRY N+N+HGTRCAGE+A ANN CGVGVAYN+++G
Sbjct: 177 IYANYDPEASYDFNDNDHDPFPRYDPTNENKHGTRCAGEIAMQANNHKCGVGVAYNSKVG 236
Query: 223 GVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGR 282
G+RMLDG VTDA+EA S+G NP H+ IYSASWGP DDGKTV+GP RLA++AF GV QGR
Sbjct: 237 GIRMLDGIVTDAIEASSIGFNPGHVDIYSASWGPNDDGKTVEGPGRLAQKAFEYGVKQGR 296
Query: 283 GGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYS 342
G GSIFVWASGNGGR+ D+C+CDGYT+SIYT+SISSA+Q G PWY+E CSSTLAT+YS
Sbjct: 297 QGKGSIFVWASGNGGRQGDNCDCDGYTDSIYTISISSASQQGLSPWYAEKCSSTLATSYS 356
Query: 343 SGNQNEKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSK 402
SG+ +++I + DL CTE+HTGTSASAPLAAGI AL LEAN NLTWRDMQHLVV TS+
Sbjct: 357 SGDYTDQRITSADLHNDCTETHTGTSASAPLAAGIFALALEANPNLTWRDMQHLVVWTSE 416
Query: 403 PAHL-NANDWATNGVGRKVSHSYGYGLLDAGAMVALA--QNWTTVAPQRKCII-DILTEP 458
L N W NG G V+ +G+GLL+A A+V LA + W +V +++C++ D EP
Sbjct: 417 YDPLANNPGWKKNGAGLMVNSRFGFGLLNAKALVDLADPRTWRSVPEKKECVVKDNDFEP 476
Query: 459 KDIGKRLEV--RKTVTACLGEPNHITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLL 516
+ + EV AC G+ N I LEH Q T+ Y+RRGDL + L S GT + LL
Sbjct: 477 RALKANGEVIIEIPTRACEGQENAIKSLEHVQFEATIEYSRRGDLHVTLTSAAGTSTVLL 536
Query: 517 AARPHDYSADGFNDWAFMTTHSWDEDPSGEWVLEIENTS-EANNYGTLTKFTLVLYGTA- 574
A R D S +GF +W FM+ H+W E+P G W L I + S N G + + L+L+GT+
Sbjct: 537 AERERDTSPNGFKNWDFMSVHTWGENPIGTWTLRITDMSGRIQNEGRIVNWKLILHGTSS 596
Query: 575 -PEGLPVP 581
PE + P
Sbjct: 597 QPEHMKQP 604
>gi|20336186 paired basic amino acid cleaving system 4 isoform c
preproprotein [Homo sapiens]
Length = 487
Score = 536 bits (1380), Expect = e-152
Identities = 263/428 (61%), Positives = 319/428 (74%), Gaps = 15/428 (3%)
Query: 4 RPWLLWVVAATGTLVLLAADAQGQKVFTNTWAVRIPGGPAVANSVARKHGFLNLGQI--F 61
RPW ++ A L + + V+TN WAV++ GGPA A+ VA HG+LNLGQI
Sbjct: 47 RPWRWLLLLA---LPAACSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNL 103
Query: 62 GDYYHFWHRGVTKRSLSPHRPRHSRLQREPQVQWLEQQVAKRRTKRDVYQEP-----TDP 116
DYYHF+H KRS R H+ L+ +PQV+WL+QQ KRR KR V +P DP
Sbjct: 104 EDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDP 163
Query: 117 KFPQQWYL-----SGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNYDPGA 171
+ WYL + + ++NV+AAW +GYTG +VV+ILDDGIE+NHPDLA NYD A
Sbjct: 164 IWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYA 223
Query: 172 SFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEV 231
S+DVN D DP PRY N+N+HGTRCAGEVAA ANN C VG+AYNA+IGG+RMLDG+V
Sbjct: 224 SYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDV 283
Query: 232 TDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVW 291
TD VEA+SLG+ PN+I IYSASWGP+DDGKTVDGP RLA++AF G+ +GR GLGSIFVW
Sbjct: 284 TDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVW 343
Query: 292 ASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQI 351
ASGNGGRE D C+CDGYTNSIYT+S+SSAT+ G PWY E C+STLATTYSSG E++I
Sbjct: 344 ASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKI 403
Query: 352 VTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDW 411
VTTDLRQ+CT+ HTGTS SAP+ AGIIAL LEAN LTWRD+QHL+V+TS+PAHL A+DW
Sbjct: 404 VTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDW 463
Query: 412 ATNGVGRK 419
NG G K
Sbjct: 464 KVNGAGHK 471
>gi|20336244 proprotein convertase subtilisin/kexin type 2 [Homo
sapiens]
Length = 638
Score = 515 bits (1326), Expect = e-146
Identities = 282/585 (48%), Positives = 368/585 (62%), Gaps = 24/585 (4%)
Query: 12 AATGTLVLLAADAQGQK-VFTNTWAVRI-PGGPAVANSVARKHGFLNLGQIFGD-YYHFW 68
AA G L + A ++ VFTN + V + GG A VA +HGF F + YHF+
Sbjct: 11 AAAGFLFCVMVFASAERPVFTNHFLVELHKGGEDKARQVAAEHGFGVRKLPFAEGLYHFY 70
Query: 69 HRGVTKRSLSPHRPRHSRLQREPQVQWLEQQVA---KRRTKRDVYQ---EPTDPKFPQQW 122
H G+ K +L+R+P+V+ QQ K+R RD+ + DP F +QW
Sbjct: 71 HNGLAKAKRRRSLHHKQQLERDPRVKMALQQEGFDRKKRGYRDINEIDINMNDPLFTKQW 130
Query: 123 YL------SGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNYDPGASFDVN 176
YL G DLNV AW GYTG G+ + I+DDGI+ HPDLA NY+ AS+D +
Sbjct: 131 YLINTGQADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFS 190
Query: 177 DQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGE-VTDAV 235
DP P PRYT N HGTRCAGEV+A ANN +CGVGVAYN+++ G+RMLD +TD +
Sbjct: 191 SNDPYPYPRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDII 250
Query: 236 EARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGN 295
EA S+ P I IYSASWGP D+GKTVDGP L +A GV++GRGG GSI+VWASG+
Sbjct: 251 EASSISHMPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGD 310
Query: 296 GGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQN--EKQIVT 353
GG +D CNCDGY +S++T+SI+SA G Y E+CSSTLA+T+S+G + E + T
Sbjct: 311 GG-SYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVAT 369
Query: 354 TDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSK--PAHLNANDW 411
TDL CT H+GTSA+AP AAG+ AL LEAN LTWRDMQHL V TSK H + W
Sbjct: 370 TDLYGNCTLRHSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRNQLHDEVHQW 429
Query: 412 ATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDIGK--RLEVRK 469
NGVG + +H +GYG+LDAGAMV +A++W TV + C+ + +P+ I +L +
Sbjct: 430 RRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQDPEKIPSTGKLVLTL 489
Query: 470 TVTACLGEPNHITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPH-DYSADGF 528
T AC G+ N + LEH QA +T++ RRGDL I++ SPMGT+S LL+ RP D S GF
Sbjct: 490 TTDACEGKENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGF 549
Query: 529 NDWAFMTTHSWDEDPSGEWVLEIENTSEANNYGTLTKFTLVLYGT 573
+ W FMTTH+W ED G W LE+ A G L ++TL+L+GT
Sbjct: 550 DKWPFMTTHTWGEDARGTWTLELGFVGSAPQKGVLKEWTLMLHGT 594
>gi|20336248 proprotein convertase subtilisin/kexin type 7
preproprotein [Homo sapiens]
Length = 785
Score = 427 bits (1097), Expect = e-119
Identities = 254/652 (38%), Positives = 355/652 (54%), Gaps = 41/652 (6%)
Query: 9 WVVAATGTLVLLAADAQGQKVFTNTWAVRIPGGPA---------VANSVARKHGFLNLGQ 59
WV+ GT GQ +WAV + A+++A+ G +N G+
Sbjct: 34 WVMGLAGT-----GGPDGQGTGGPSWAVHLESLEGDGEEETLEQQADALAQAAGLVNAGR 88
Query: 60 I--FGDYYHFWHRGVTKRSLSPHRPRH---SRLQREPQVQWLEQQVAKRRTKRDVYQEPT 114
I +Y F + +L R + L V+W +Q RR KR V+
Sbjct: 89 IGELQGHYLFVQPAGHRPALEVEAIRQQVEAVLAGHEAVRWHSEQRLLRRAKRSVHFN-- 146
Query: 115 DPKFPQQWYLSGVTQ--RDLNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNYDPGAS 172
DPK+PQQW+L+ RD+NV W + TG G+ V ++DDG+E D+A NY P S
Sbjct: 147 DPKYPQQWHLNNRRSPGRDINVTGVWERNVTGRGVTVVVVDDGVEHTIQDIAPNYSPEGS 206
Query: 173 FDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVT 232
+D+N DPDP P N N HGTRCAGE+AAV NN C VGVAY +RI G+R+LDG +T
Sbjct: 207 YDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVPNNSFCAVGVAYGSRIAGIRVLDGPLT 266
Query: 233 DAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWA 292
D++EA + + IYS SWGP+DDGKTVDGP +L + A GV GR G GSIFV A
Sbjct: 267 DSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPHQLGKAALQHGVIAGRQGFGSIFVVA 326
Query: 293 SGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIV 352
SGNGG+ +D+CN DGY NSIYT++I + + G +P+Y+E C+S LA T+S G++ + IV
Sbjct: 327 SGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTFSGGDKMLRSIV 386
Query: 353 TTDLRQK----CTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNA 408
TTD + CTE HTGTSA+APLAAG+IAL L+ LTWRD+QH++V T+
Sbjct: 387 TTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVFTATRYEDRR 446
Query: 409 NDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDI---GKRL 465
+W TN G SH +G+GLL+A +V A+ WT+V + +L E K I + L
Sbjct: 447 AEWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPVLKENKAIPQSPRSL 506
Query: 466 EVRKTVTACLGEPNHITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSA 525
EV V+ E + + LEH +++++ RRG L + L P G S + A R D
Sbjct: 507 EVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRGSLELKLFCPSGMMSLIGAPRSMDSDP 566
Query: 526 DGFNDWAFMTTHSWDEDPSGEWVLEIENT-SEANNYGTLTKFTLVLYGTAPEGLPVPPES 584
+GFNDW F T W E G + L I + E+ G L ++ L LYG+ + +
Sbjct: 567 NGFNDWTFSTVRCWGERARGTYRLVIRDVGDESFQVGILRQWQLTLYGSVWSAVDIRDRQ 626
Query: 585 SGCKTLTSSQACVVCEEGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETI 636
+ L S+ + + F+L CPPG D + T N ++T+
Sbjct: 627 ---RLLESAMSGKYLHDDFAL-------PCPPGLKIPEEDGYTITPNTLKTL 668
>gi|239755070 PREDICTED: similar to proprotein convertase
subtilisin/kexin type 5 [Homo sapiens]
Length = 853
Score = 53.5 bits (127), Expect = 7e-07
Identities = 35/98 (35%), Positives = 41/98 (41%), Gaps = 22/98 (22%)
Query: 571 YGTAPEGLPVPPESSGCKTLTSS------QACVVCEEGFSLHQKSCVQHCPPGFAPQVLD 624
Y T PE E+ CK S+ C CEEGF L SCV+ C PGF
Sbjct: 61 YKTCPE--KTYSEAVECKACDSNCSSCDQNGCYWCEEGFFLLGGSCVRKCGPGF------ 112
Query: 625 THYSTENDVETIRASVCAPCHASCATCQGPALTDCLSC 662
Y + E C CH +C TC GP +C SC
Sbjct: 113 --YGDQEMGE------CESCHRACETCTGPGHDECSSC 142
Score = 50.8 bits (120), Expect = 5e-06
Identities = 25/76 (32%), Positives = 29/76 (38%), Gaps = 16/76 (21%)
Query: 587 CKTLTSSQACVVCEEGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCAPCHA 646
C+ + C C F LH C Q CP GF D+H+ C PCH
Sbjct: 323 CQDCIHEKTCKECMPEFFLHDDMCHQSCPRGF---YADSHH-------------CVPCHK 366
Query: 647 SCATCQGPALTDCLSC 662
C C GP DC C
Sbjct: 367 DCLECSGPKADDCELC 382
Score = 48.1 bits (113), Expect = 3e-05
Identities = 29/92 (31%), Positives = 43/92 (46%), Gaps = 19/92 (20%)
Query: 587 CKTLTSSQACVVCEEGFSLHQK-SCV--QHCPPGFAPQVLDTHYSTENDVETIRASVCAP 643
C T +SS C C++G ++ + SC+ + C P + Y E+ A C P
Sbjct: 418 CLTCSSSGTCTTCQKGLIMNPRGSCMANEKCSP--------SEYWDED------APGCKP 463
Query: 644 CHASCATCQGPALTDCLSCPSHASLDPVEQTC 675
CH C C GPA C +CP ++ L + TC
Sbjct: 464 CHVKCFHCMGPAEDQCQTCPMNSLL--LNTTC 493
Score = 46.6 bits (109), Expect = 9e-05
Identities = 33/112 (29%), Positives = 41/112 (36%), Gaps = 33/112 (29%)
Query: 585 SGCKTLTS--SQACVVCEEGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCA 642
S C+T S+ C C G+ K C+ C G Y +N C
Sbjct: 515 SSCRTCEGRHSRQCHSCRPGWFQLGKECLLQCREG---------YYADNSTGR-----CE 560
Query: 643 PCHASCATCQGPALTDCL-----------------SCPSHASLDPVEQTCSR 677
C+ SC CQGP TDCL SCP H ++ QTC R
Sbjct: 561 RCNRSCKGCQGPRPTDCLSCDRFFFLLRSKGECHRSCPDHYYVEQSTQTCER 612
Score = 42.4 bits (98), Expect = 0.002
Identities = 27/86 (31%), Positives = 34/86 (39%), Gaps = 16/86 (18%)
Query: 582 PESSGCKTLTSSQA-CVVCEEGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASV 640
P S CKT S C C +G L ++CV CP G P ++R+
Sbjct: 175 PCHSSCKTCNGSATLCTSCPKGAYLLAQACVSSCPQGTWP--------------SVRSGS 220
Query: 641 CAPCHASCATCQGPAL-TDCLSCPSH 665
C C +CA C G L C P H
Sbjct: 221 CENCTEACAICSGADLCKKCQMQPGH 246
Score = 42.4 bits (98), Expect = 0.002
Identities = 22/67 (32%), Positives = 31/67 (46%), Gaps = 14/67 (20%)
Query: 596 CVVCEEGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCAPCHASCATCQGPA 655
C C L +CV+ CP G+ Y+ E+ ++ CA CH+SC TC+G
Sbjct: 479 CQTCPMNSLLLNTTCVKDCPEGY--------YADED------SNRCAHCHSSCRTCEGRH 524
Query: 656 LTDCLSC 662
C SC
Sbjct: 525 SRQCHSC 531
Score = 39.7 bits (91), Expect = 0.011
Identities = 18/50 (36%), Positives = 23/50 (46%), Gaps = 2/50 (4%)
Query: 641 CAPCHASCATCQGPALTDCLSCPSHASLDPVEQTCSRQSQSSRESPPQQQ 690
C CH SC C+GP +C CP++ L E C +S PP Q
Sbjct: 661 CEKCHESCMECKGPGAKNCTLCPANLVLHMDESHCLHCCNTS--DPPSAQ 708
Score = 38.5 bits (88), Expect = 0.025
Identities = 21/69 (30%), Positives = 29/69 (42%), Gaps = 16/69 (23%)
Query: 596 CVVCEEGFSLHQKS--CVQHCPPGFAPQVLDTHYSTENDVETIRASVCAPCHASCATCQG 653
C+ C+ F L + C + CP HY E +T C CH +C C+G
Sbjct: 577 CLSCDRFFFLLRSKGECHRSCPD---------HYYVEQSTQT-----CERCHPTCDQCKG 622
Query: 654 PALTDCLSC 662
+CLSC
Sbjct: 623 KGALNCLSC 631
Score = 35.4 bits (80), Expect = 0.21
Identities = 25/105 (23%), Positives = 39/105 (37%), Gaps = 17/105 (16%)
Query: 596 CVVC-EEGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCAPCHASCATCQGP 654
C +C E + L+ C++ CP G T+Y + C CH SC TC
Sbjct: 379 CELCLESSWVLYDGLCLEECPAG-------TYYEKQ-------TKECRDCHKSCLTCSSS 424
Query: 655 ALTDCLSCPSHASLDPVEQTCSRQSQSSRESPPQQQPPRLPPEVE 699
C +C ++P + + S E + P P V+
Sbjct: 425 G--TCTTCQKGLIMNPRGSCMANEKCSPSEYWDEDAPGCKPCHVK 467
>gi|239749596 PREDICTED: hypothetical protein XP_002347099 [Homo
sapiens]
Length = 853
Score = 53.5 bits (127), Expect = 7e-07
Identities = 35/98 (35%), Positives = 41/98 (41%), Gaps = 22/98 (22%)
Query: 571 YGTAPEGLPVPPESSGCKTLTSS------QACVVCEEGFSLHQKSCVQHCPPGFAPQVLD 624
Y T PE E+ CK S+ C CEEGF L SCV+ C PGF
Sbjct: 61 YKTCPE--KTYSEAVECKACDSNCGSCDQNGCYWCEEGFFLLGGSCVRKCGPGF------ 112
Query: 625 THYSTENDVETIRASVCAPCHASCATCQGPALTDCLSC 662
Y + E C CH +C TC GP +C SC
Sbjct: 113 --YGDQEMGE------CESCHRACETCTGPGHDECSSC 142
Score = 48.1 bits (113), Expect = 3e-05
Identities = 24/76 (31%), Positives = 28/76 (36%), Gaps = 16/76 (21%)
Query: 587 CKTLTSSQACVVCEEGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCAPCHA 646
C+ + C C F LH C Q CP GF D+ + C PCH
Sbjct: 323 CQDCIHEKTCKECTPEFFLHDDMCHQSCPRGF---YADSRH-------------CVPCHK 366
Query: 647 SCATCQGPALTDCLSC 662
C C GP DC C
Sbjct: 367 DCLECSGPKADDCELC 382
Score = 48.1 bits (113), Expect = 3e-05
Identities = 29/92 (31%), Positives = 43/92 (46%), Gaps = 19/92 (20%)
Query: 587 CKTLTSSQACVVCEEGFSLHQK-SCV--QHCPPGFAPQVLDTHYSTENDVETIRASVCAP 643
C T +SS C C++G ++ + SC+ + C P + Y E+ A C P
Sbjct: 418 CLTCSSSGTCTTCQKGLIMNPRGSCMANEKCSP--------SEYWDED------APGCKP 463
Query: 644 CHASCATCQGPALTDCLSCPSHASLDPVEQTC 675
CH C C GPA C +CP ++ L + TC
Sbjct: 464 CHVKCFHCMGPAEDQCQTCPMNSLL--LNTTC 493
Score = 46.6 bits (109), Expect = 9e-05
Identities = 33/112 (29%), Positives = 41/112 (36%), Gaps = 33/112 (29%)
Query: 585 SGCKTLTS--SQACVVCEEGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCA 642
S C+T S+ C C G+ K C+ C G Y +N C
Sbjct: 515 SSCRTCEGRHSRQCHSCRPGWFQLGKECLLQCREG---------YYADNSTGR-----CE 560
Query: 643 PCHASCATCQGPALTDCL-----------------SCPSHASLDPVEQTCSR 677
C+ SC CQGP TDCL SCP H ++ QTC R
Sbjct: 561 RCNRSCKGCQGPRPTDCLSCDRFFFLLRSKGECHRSCPDHYYVEQSTQTCER 612
Score = 42.4 bits (98), Expect = 0.002
Identities = 27/86 (31%), Positives = 34/86 (39%), Gaps = 16/86 (18%)
Query: 582 PESSGCKTLTSSQA-CVVCEEGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASV 640
P S CKT S C C +G L ++CV CP G P ++R+
Sbjct: 175 PCHSSCKTCNGSATLCTSCPKGAYLLAQACVSSCPQGTWP--------------SVRSGS 220
Query: 641 CAPCHASCATCQGPAL-TDCLSCPSH 665
C C +CA C G L C P H
Sbjct: 221 CENCTEACAICSGADLCKKCQMQPGH 246
Score = 42.4 bits (98), Expect = 0.002
Identities = 22/67 (32%), Positives = 31/67 (46%), Gaps = 14/67 (20%)
Query: 596 CVVCEEGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCAPCHASCATCQGPA 655
C C L +CV+ CP G+ Y+ E+ ++ CA CH+SC TC+G
Sbjct: 479 CQTCPMNSLLLNTTCVKDCPEGY--------YADED------SNRCAHCHSSCRTCEGRH 524
Query: 656 LTDCLSC 662
C SC
Sbjct: 525 SRQCHSC 531
Score = 38.5 bits (88), Expect = 0.025
Identities = 21/69 (30%), Positives = 29/69 (42%), Gaps = 16/69 (23%)
Query: 596 CVVCEEGFSLHQKS--CVQHCPPGFAPQVLDTHYSTENDVETIRASVCAPCHASCATCQG 653
C+ C+ F L + C + CP HY E +T C CH +C C+G
Sbjct: 577 CLSCDRFFFLLRSKGECHRSCPD---------HYYVEQSTQT-----CERCHPTCDQCKG 622
Query: 654 PALTDCLSC 662
+CLSC
Sbjct: 623 KGALNCLSC 631
Score = 38.5 bits (88), Expect = 0.025
Identities = 17/50 (34%), Positives = 23/50 (46%), Gaps = 2/50 (4%)
Query: 641 CAPCHASCATCQGPALTDCLSCPSHASLDPVEQTCSRQSQSSRESPPQQQ 690
C CH SC C+GP +C CP++ L + C +S PP Q
Sbjct: 661 CEKCHESCMECKGPGAKNCTLCPANLVLHMDDSHCLHCCNTS--DPPSAQ 708
Score = 36.6 bits (83), Expect = 0.094
Identities = 26/105 (24%), Positives = 39/105 (37%), Gaps = 17/105 (16%)
Query: 596 CVVC-EEGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCAPCHASCATCQGP 654
C +C E + L+ C++ CP G T+Y E C CH SC TC
Sbjct: 379 CELCLESSWVLYDGLCLEECPAG-------TYYEKE-------TKECRDCHKSCLTCSSS 424
Query: 655 ALTDCLSCPSHASLDPVEQTCSRQSQSSRESPPQQQPPRLPPEVE 699
C +C ++P + + S E + P P V+
Sbjct: 425 G--TCTTCQKGLIMNPRGSCMANEKCSPSEYWDEDAPGCKPCHVK 467
>gi|239743863 PREDICTED: hypothetical protein XP_002342982 [Homo
sapiens]
Length = 853
Score = 53.1 bits (126), Expect = 1e-06
Identities = 35/98 (35%), Positives = 40/98 (40%), Gaps = 22/98 (22%)
Query: 571 YGTAPEGLPVPPESSGCKTLTSS------QACVVCEEGFSLHQKSCVQHCPPGFAPQVLD 624
Y T PE E CK S+ C CEEGF L SCV+ C PGF
Sbjct: 61 YKTCPE--KTYSEEVECKACDSNCGSCDQNGCYWCEEGFFLLGGSCVRKCGPGF------ 112
Query: 625 THYSTENDVETIRASVCAPCHASCATCQGPALTDCLSC 662
Y + E C CH +C TC GP +C SC
Sbjct: 113 --YGDQEMGE------CESCHRACETCTGPGHDECSSC 142
Score = 48.1 bits (113), Expect = 3e-05
Identities = 24/76 (31%), Positives = 28/76 (36%), Gaps = 16/76 (21%)
Query: 587 CKTLTSSQACVVCEEGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCAPCHA 646
C+ + C C F LH C Q CP GF D+ + C PCH
Sbjct: 323 CQDCIHEKTCKECTPEFFLHDDMCHQSCPRGF---YADSRH-------------CVPCHK 366
Query: 647 SCATCQGPALTDCLSC 662
C C GP DC C
Sbjct: 367 DCLECSGPKADDCELC 382
Score = 48.1 bits (113), Expect = 3e-05
Identities = 29/92 (31%), Positives = 43/92 (46%), Gaps = 19/92 (20%)
Query: 587 CKTLTSSQACVVCEEGFSLHQK-SCV--QHCPPGFAPQVLDTHYSTENDVETIRASVCAP 643
C T +SS C C++G ++ + SC+ + C P + Y E+ A C P
Sbjct: 418 CLTCSSSGTCTTCQKGLIMNPRGSCMANEKCSP--------SEYWDED------APGCKP 463
Query: 644 CHASCATCQGPALTDCLSCPSHASLDPVEQTC 675
CH C C GPA C +CP ++ L + TC
Sbjct: 464 CHVKCFHCMGPAEDQCQTCPMNSLL--LNTTC 493
Score = 46.6 bits (109), Expect = 9e-05
Identities = 33/112 (29%), Positives = 41/112 (36%), Gaps = 33/112 (29%)
Query: 585 SGCKTLTS--SQACVVCEEGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCA 642
S C+T S+ C C G+ K C+ C G Y +N C
Sbjct: 515 SSCRTCEGRHSRQCHSCRPGWFQLGKECLLQCREG---------YYADNSTGR-----CE 560
Query: 643 PCHASCATCQGPALTDCL-----------------SCPSHASLDPVEQTCSR 677
C+ SC CQGP TDCL SCP H ++ QTC R
Sbjct: 561 RCNRSCKGCQGPRPTDCLSCDRFFFLLRSKGECHRSCPDHYYVEQSTQTCER 612
Score = 42.4 bits (98), Expect = 0.002
Identities = 27/86 (31%), Positives = 34/86 (39%), Gaps = 16/86 (18%)
Query: 582 PESSGCKTLTSSQA-CVVCEEGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASV 640
P S CKT S C C +G L ++CV CP G P ++R+
Sbjct: 175 PCHSSCKTCNGSATLCTSCPKGAYLLAQACVSSCPQGTWP--------------SVRSGS 220
Query: 641 CAPCHASCATCQGPAL-TDCLSCPSH 665
C C +CA C G L C P H
Sbjct: 221 CENCTEACAICSGADLCKKCQMQPGH 246
Score = 42.4 bits (98), Expect = 0.002
Identities = 22/67 (32%), Positives = 31/67 (46%), Gaps = 14/67 (20%)
Query: 596 CVVCEEGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCAPCHASCATCQGPA 655
C C L +CV+ CP G+ Y+ E+ ++ CA CH+SC TC+G
Sbjct: 479 CQTCPMNSLLLNTTCVKDCPEGY--------YADED------SNRCAHCHSSCRTCEGRH 524
Query: 656 LTDCLSC 662
C SC
Sbjct: 525 SRQCHSC 531
Score = 38.5 bits (88), Expect = 0.025
Identities = 21/69 (30%), Positives = 29/69 (42%), Gaps = 16/69 (23%)
Query: 596 CVVCEEGFSLHQKS--CVQHCPPGFAPQVLDTHYSTENDVETIRASVCAPCHASCATCQG 653
C+ C+ F L + C + CP HY E +T C CH +C C+G
Sbjct: 577 CLSCDRFFFLLRSKGECHRSCPD---------HYYVEQSTQT-----CERCHPTCDQCKG 622
Query: 654 PALTDCLSC 662
+CLSC
Sbjct: 623 KGALNCLSC 631
Score = 38.5 bits (88), Expect = 0.025
Identities = 17/50 (34%), Positives = 23/50 (46%), Gaps = 2/50 (4%)
Query: 641 CAPCHASCATCQGPALTDCLSCPSHASLDPVEQTCSRQSQSSRESPPQQQ 690
C CH SC C+GP +C CP++ L + C +S PP Q
Sbjct: 661 CEKCHESCMECKGPGAKNCTLCPANLVLHMDDSHCLHCCNTS--DPPSAQ 708
Score = 36.6 bits (83), Expect = 0.094
Identities = 26/105 (24%), Positives = 39/105 (37%), Gaps = 17/105 (16%)
Query: 596 CVVC-EEGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCAPCHASCATCQGP 654
C +C E + L+ C++ CP G T+Y E C CH SC TC
Sbjct: 379 CELCLESSWVLYDGLCLEECPAG-------TYYEKE-------TKECRDCHKSCLTCSSS 424
Query: 655 ALTDCLSCPSHASLDPVEQTCSRQSQSSRESPPQQQPPRLPPEVE 699
C +C ++P + + S E + P P V+
Sbjct: 425 G--TCTTCQKGLIMNPRGSCMANEKCSPSEYWDEDAPGCKPCHVK 467
>gi|108773804 Fraser syndrome 1 [Homo sapiens]
Length = 4011
Score = 47.8 bits (112), Expect = 4e-05
Identities = 31/94 (32%), Positives = 36/94 (38%), Gaps = 19/94 (20%)
Query: 587 CKTLTSSQACVVCEEGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCAPCHA 646
C T TS C C+ + CV C GF D H CA CH
Sbjct: 472 CSTCTSGLECSSCQPPLLMRHGQCVPTCGDGFYQ---DRHS-------------CAVCHE 515
Query: 647 SCATCQGPALTDCLSC--PSHASLD-PVEQTCSR 677
SCA C GP CL+C P H D E +C +
Sbjct: 516 SCAGCWGPTEKHCLACRDPLHVLRDGGCESSCGK 549
Score = 47.0 bits (110), Expect = 7e-05
Identities = 22/71 (30%), Positives = 28/71 (39%), Gaps = 15/71 (21%)
Query: 592 SSQACVVCEEGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCAPCHASCATC 651
SS C+ C E LH C+ CP G+ C CH SCA+C
Sbjct: 571 SSPRCLTCTEKTVLHDGKCMSECPGGYYADATGR---------------CKVCHNSCASC 615
Query: 652 QGPALTDCLSC 662
GP + C +C
Sbjct: 616 SGPTPSHCTAC 626
Score = 45.4 bits (106), Expect = 2e-04
Identities = 23/77 (29%), Positives = 28/77 (36%), Gaps = 16/77 (20%)
Query: 592 SSQACVVCEEGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCAPCHASCATC 651
S C C L C+ CP G+ Q C CH +C C
Sbjct: 725 SPHNCTDCGPSHVLLDGQCLSQCPDGYFHQ----------------EGSCTECHPTCRQC 768
Query: 652 QGPALTDCLSCPSHASL 668
GP +DC+SC H SL
Sbjct: 769 HGPLESDCISCYPHISL 785
Score = 43.5 bits (101), Expect = 8e-04
Identities = 28/89 (31%), Positives = 33/89 (37%), Gaps = 17/89 (19%)
Query: 585 SGCKTLTSSQACVVCEEGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCAPC 644
+ C T S C C +L Q C+ C GF YS VC C
Sbjct: 613 ASCSGPTPSH-CTACSPPKALRQGHCLPRCGEGF--------YSDHG--------VCKAC 655
Query: 645 HASCATCQGPALTDCLSCPSHASLDPVEQ 673
H+SC C GPA + C C VEQ
Sbjct: 656 HSSCLACMGPAPSHCTGCKKPEEGLQVEQ 684
Score = 40.8 bits (94), Expect = 0.005
Identities = 29/92 (31%), Positives = 36/92 (39%), Gaps = 17/92 (18%)
Query: 579 PVPPESSGCKTLTSSQACVVCEEGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRA 638
P P +GCK EEG + Q S V P G H+ E+
Sbjct: 665 PAPSHCTGCKKP---------EEGLQVEQLSDVG-IPSGECLAQCRAHFYLES------T 708
Query: 639 SVCAPCHASCATCQGPALTDCLSC-PSHASLD 669
+C CH SC C G + +C C PSH LD
Sbjct: 709 GICEACHQSCFRCAGKSPHNCTDCGPSHVLLD 740
Score = 38.9 bits (89), Expect = 0.019
Identities = 24/82 (29%), Positives = 32/82 (39%), Gaps = 18/82 (21%)
Query: 596 CVVCEEG-FSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCAPCHASCATCQGP 654
C+ C+ + L CV CP G+ + C CH+SC TCQG
Sbjct: 827 CLRCQNAHYLLLGDHCVPDCPSGYYAE----------------RGACKKCHSSCRTCQGR 870
Query: 655 ALTDCLSCPSHASLDPVEQTCS 676
C SC ++ L TCS
Sbjct: 871 GPFSCSSCDTNLVLSHT-GTCS 891
Score = 35.4 bits (80), Expect = 0.21
Identities = 24/83 (28%), Positives = 35/83 (42%), Gaps = 16/83 (19%)
Query: 582 PESSGCKTLTSSQACVVCEEGFS--LHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRAS 639
P ++ C + S +C C + L + + C P + LD +ST +
Sbjct: 908 PCNTHCGSCDSQASCTSCRDPNKVLLFGECQYESCAPQY---YLD--FST---------N 953
Query: 640 VCAPCHASCATCQGPALTDCLSC 662
C C SC+ C GP TDCL C
Sbjct: 954 TCKECDWSCSACSGPLKTDCLQC 976
Score = 33.9 bits (76), Expect = 0.61
Identities = 24/81 (29%), Positives = 31/81 (38%), Gaps = 20/81 (24%)
Query: 585 SGCKTLTSSQ--ACVVCEEGFSL-HQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVC 641
S C+T +C C+ L H +C C PG HY +N V C
Sbjct: 862 SSCRTCQGRGPFSCSSCDTNLVLSHTGTCSTTCFPG--------HYLDDNHV-------C 906
Query: 642 APCHASCATCQGPALTDCLSC 662
PC+ C +C A C SC
Sbjct: 907 QPCNTHCGSCDSQA--SCTSC 925
Score = 33.9 bits (76), Expect = 0.61
Identities = 13/34 (38%), Positives = 18/34 (52%)
Query: 586 GCKTLTSSQACVVCEEGFSLHQKSCVQHCPPGFA 619
GC + C +C+ GF L CV +C PGF+
Sbjct: 1054 GCLQCSHRDRCHLCDHGFFLKSGLCVYNCVPGFS 1087
Score = 30.0 bits (66), Expect = 8.8
Identities = 17/67 (25%), Positives = 25/67 (37%), Gaps = 19/67 (28%)
Query: 596 CVVCEEGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCAPCHASCATCQGPA 655
C+ C +G+ L +CV+ C F + S C + C CQGP
Sbjct: 973 CLQCMDGYVLQDGACVEQCLSSF-----------------YQDSGLCKCDSYCLQCQGP- 1014
Query: 656 LTDCLSC 662
+C C
Sbjct: 1015 -HECTRC 1020
>gi|222446611 R-spondin family, member 2 [Homo sapiens]
Length = 243
Score = 38.9 bits (89), Expect = 0.019
Identities = 15/34 (44%), Positives = 18/34 (52%)
Query: 587 CKTLTSSQACVVCEEGFSLHQKSCVQHCPPGFAP 620
C + S C C+ GF LH+ C CP GFAP
Sbjct: 101 CDSCFSKDFCTKCKVGFYLHRGRCFDECPDGFAP 134
>gi|54792100 erbB-3 isoform 1 precursor [Homo sapiens]
Length = 1342
Score = 36.2 bits (82), Expect = 0.12
Identities = 32/125 (25%), Positives = 46/125 (36%), Gaps = 19/125 (15%)
Query: 553 NTSEANNYGTLTKFTLVLYGTAPEGLPVPPESSGCKTLTSSQACVVCEEGFSLHQKSCVQ 612
N+S A LT+ T +L G G+ + C T +V + + K +
Sbjct: 126 NSSHALRQLRLTQLTEILSG----GVYIEKNDKLCHMDTIDWRDIVRDRDAEIVVKDNGR 181
Query: 613 HCPPGFAPQVLDTHYSTENDVETIRASVCAP--------------CHASCAT-CQGPALT 657
CPP D +T+ ++CAP CH CA C GP T
Sbjct: 182 SCPPCHEVCKGRCWGPGSEDCQTLTKTICAPQCNGHCFGPNPNQCCHDECAGGCSGPQDT 241
Query: 658 DCLSC 662
DC +C
Sbjct: 242 DCFAC 246
Score = 34.7 bits (78), Expect = 0.36
Identities = 24/83 (28%), Positives = 32/83 (38%), Gaps = 13/83 (15%)
Query: 581 PPESSGCKTLTSSQACVVCEEGFSLHQKSCVQHCPPGF--APQVLDTHYSTENDVETIRA 638
P E + + S C C CV CP G A + + +N+
Sbjct: 558 PMEGTATCNGSGSDTCAQCAH--FRDGPHCVSSCPHGVLGAKGPIYKYPDVQNE------ 609
Query: 639 SVCAPCHASCAT-CQGPALTDCL 660
C PCH +C C+GP L DCL
Sbjct: 610 --CRPCHENCTQGCKGPELQDCL 630
Score = 30.0 bits (66), Expect = 8.8
Identities = 18/60 (30%), Positives = 25/60 (41%), Gaps = 14/60 (23%)
Query: 596 CVV-CEEGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCAPCHASC-ATCQG 653
CV C F + Q SCV+ CPP + +V+ +C PC C C+G
Sbjct: 286 CVASCPHNFVVDQTSCVRACPP------------DKMEVDKNGLKMCEPCGGLCPKACEG 333
>gi|18490982 R-spondin 3 [Homo sapiens]
Length = 272
Score = 35.8 bits (81), Expect = 0.16
Identities = 20/70 (28%), Positives = 28/70 (40%), Gaps = 10/70 (14%)
Query: 587 CKTLTSSQACVVCEEGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVC----- 641
C T + C C+ GF LH C+ +CP G L+ + T V + V
Sbjct: 102 CDTCFNKNFCTKCKSGFYLHLGKCLDNCPEG-----LEANNHTMECVSIVHCEVSEWNPW 156
Query: 642 APCHASCATC 651
+PC TC
Sbjct: 157 SPCTKKGKTC 166
>gi|181336739 multiple EGF-like-domains 11 [Homo sapiens]
Length = 1044
Score = 35.8 bits (81), Expect = 0.16
Identities = 28/109 (25%), Positives = 44/109 (40%), Gaps = 12/109 (11%)
Query: 578 LPVPPESSGCKTLTSSQACVVCEEGFSLHQKSCVQHCPPGFAPQVLDTHYSTEN--DVET 635
LP P ++ + C+ G+S H C + CP G+ + +N D +
Sbjct: 360 LPCPCDADNTISCHPVTGACTCQPGWSGHH--CNESCPVGYYGDGCQLPCTCQNGADCHS 417
Query: 636 IRAS-VCAP------CHASCAT-CQGPALTDCLSCPSHASLDPVEQTCS 676
I CAP C SCA GP + SC + + PV+ +C+
Sbjct: 418 ITGGCTCAPGFMGEVCAVSCAAGTYGPNCSSICSCNNGGTCSPVDGSCT 466
>gi|205360958 cysteine-rich with EGF-like domains 2 isoform b [Homo
sapiens]
Length = 353
Score = 35.0 bits (79), Expect = 0.27
Identities = 18/49 (36%), Positives = 21/49 (42%), Gaps = 2/49 (4%)
Query: 639 SVCAPCHASCATCQGPALTDCLSCPSHASLDPVEQTCSRQSQSSRESPP 687
S+C C SC TC G DC C LD E C + + E PP
Sbjct: 194 SICTACDESCKTCSGLTNRDCGECEVGWVLD--EGACVDVDECAAEPPP 240
Score = 34.3 bits (77), Expect = 0.47
Identities = 28/113 (24%), Positives = 46/113 (40%), Gaps = 16/113 (14%)
Query: 587 CKTLT--SSQACVVCEEGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCAPC 644
CKT + +++ C CE G+ L + +CV P +N + C C
Sbjct: 203 CKTCSGLTNRDCGECEVGWVLDEGACVDVDECAAEPPPCSAAQFCKN---ANGSYTCEEC 259
Query: 645 HASCATCQGPALTDCLSCPSH--------ASLDP---VEQTCSRQSQSSRESP 686
+SC C G +C C S A +D E+TC R++++ +P
Sbjct: 260 DSSCVGCTGEGPGNCKECISGYAREHGQCADVDECSLAEKTCVRKNENCYNTP 312
>gi|205360956 cysteine-rich with EGF-like domains 2 isoform a [Homo
sapiens]
Length = 402
Score = 35.0 bits (79), Expect = 0.27
Identities = 29/119 (24%), Positives = 47/119 (39%), Gaps = 16/119 (13%)
Query: 581 PPESSGCKTLT--SSQACVVCEEGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRA 638
P CKT + +++ C CE G+ L + +CV P +N +
Sbjct: 246 PACDESCKTCSGLTNRDCGECEVGWVLDEGACVDVDECAAEPPPCSAAQFCKN---ANGS 302
Query: 639 SVCAPCHASCATCQGPALTDCLSCPSH--------ASLDP---VEQTCSRQSQSSRESP 686
C C +SC C G +C C S A +D E+TC R++++ +P
Sbjct: 303 YTCEECDSSCVGCTGEGPGNCKECISGYAREHGQCADVDECSLAEKTCVRKNENCYNTP 361
>gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]
Length = 1541
Score = 34.7 bits (78), Expect = 0.36
Identities = 31/106 (29%), Positives = 40/106 (37%), Gaps = 17/106 (16%)
Query: 581 PPESSGCKTLTSSQACVVCEEGFSLHQKSCVQHCPPG-FAP---QVLDTHYSTENDVETI 636
P E+ C T + +C H SC Q CPPG + P Q+ D T
Sbjct: 1178 PGENPACHPATGTCSCAA-----GYHGPSCQQRCPPGRYGPGCEQLCGCLNGGSCDAAT- 1231
Query: 637 RASVC------APCHASCATCQ-GPALTDCLSCPSHASLDPVEQTC 675
A C C+ +C + GP T C A+ DPV TC
Sbjct: 1232 GACRCPTGFLGTDCNLTCPQGRFGPNCTHVCGCGQGAACDPVTGTC 1277
Score = 30.0 bits (66), Expect = 8.8
Identities = 42/162 (25%), Positives = 54/162 (33%), Gaps = 25/162 (15%)
Query: 571 YGTAPEGLPVPP--ESSGCKTLTSSQ---------ACVVCEEGFSLHQKSCVQHCPPGFA 619
YG A E P PP +GC+ L Q +C GF H C + C PG
Sbjct: 1370 YGQACEH-PCPPGFHGAGCQGLCWCQHGAPCDPISGRCLCPAGF--HGHFCERGCEPGSF 1426
Query: 620 PQVLDTHYSTENDV--ETIRASVCAPCHASCATCQ--------GPALTDCLSCPSHASLD 669
+ + + + P S ATC GP+ T C A D
Sbjct: 1427 GEGCHQRCDCDGGAPCDPVTGLCLCPPGRSGATCNLDCRRGQFGPSCTLHCDCGGGADCD 1486
Query: 670 PVEQTCSRQSQSSRESPPQQQPPRLPPEVEAGQRLRAGLLPS 711
PV C + + P RLP Q AG LP+
Sbjct: 1487 PVSGQCHCVDGYMGPTCREGGPLRLPENPSLAQG-SAGTLPA 1527
>gi|122937257 thrombospondin, type I, domain containing 7B [Homo
sapiens]
Length = 1577
Score = 34.7 bits (78), Expect = 0.36
Identities = 42/166 (25%), Positives = 67/166 (40%), Gaps = 23/166 (13%)
Query: 547 WVLEIENTSEANNYGTLTKFTLVLYGTAPEGLPVPPESSGCKT----------LTSSQAC 596
W E + + G +++ ++ T EG P P E + KT L + AC
Sbjct: 1224 WTAWTECSQTCGHGGRMSRTRFIIMPTQGEGRPCPTELTQEKTCPVTPCYSWVLGNWSAC 1283
Query: 597 VV----CEEGFSLHQKSCVQHCP--PGFAPQVLDTHYSTENDVETIRASVCA-PCHASCA 649
+ C EG + SC+ H A +V D ++I +C+ PC C
Sbjct: 1284 KLEGGDCGEGVQIRSLSCMVHSGSISHAAGRVEDALCGEMPFQDSILKQLCSVPCPGDCH 1343
Query: 650 TCQGPALTDC-LSCPSHASLDPV-EQTCSR----QSQSSRESPPQQ 689
+ + C L+C S + V Q+ SR QS +++S PQQ
Sbjct: 1344 LTEWSEWSTCELTCIDGRSFETVGRQSRSRTFIIQSFENQDSCPQQ 1389
>gi|4507577 tumor necrosis factor receptor 2 precursor [Homo
sapiens]
Length = 461
Score = 34.3 bits (77), Expect = 0.47
Identities = 24/70 (34%), Positives = 30/70 (42%), Gaps = 10/70 (14%)
Query: 610 CVQHCPPGFAPQVLDTHYSTENDVETIRASVCAPCHASCATCQGPALTDCLSCPSHASLD 669
C C PG +V T S +VC C S T + +CLSC S S D
Sbjct: 53 CCSKCSPGQHAKVFCTKTSD---------TVCDSCEDSTYTQLWNWVPECLSCGSRCSSD 103
Query: 670 PVE-QTCSRQ 678
VE Q C+R+
Sbjct: 104 QVETQACTRE 113
>gi|4757836 BRCA1 associated protein-1 [Homo sapiens]
Length = 729
Score = 33.9 bits (76), Expect = 0.61
Identities = 35/111 (31%), Positives = 44/111 (39%), Gaps = 8/111 (7%)
Query: 647 SCATCQGPALTDCLSCPSHASLDPVEQTCSRQSQSSRESPPQQQPPRL--PPEVEAGQRL 704
SCAT AL L S L P T SR ++ P+ + + PE+
Sbjct: 90 SCAT---HALLSVLLNCSSVDLGP---TLSRMKDFTKGFSPESKGYAIGNAPELAKAHNS 143
Query: 705 RAGLLPSHLPEVVAGLSCAFIVLVFVTVFLVLQLRSGFSFRGVKVYTMDRG 755
A P HLPE GLS + F V V F G+KVY +D G
Sbjct: 144 HARPEPRHLPEKQNGLSAVRTMEAFHFVSYVPITGRLFELDGLKVYPIDHG 194
>gi|110825958 v-erb-a erythroblastic leukemia viral oncogene homolog
4 isoform JM-a/CVT-2 precursor [Homo sapiens]
Length = 1292
Score = 33.5 bits (75), Expect = 0.79
Identities = 18/49 (36%), Positives = 22/49 (44%), Gaps = 15/49 (30%)
Query: 629 TENDVETIRASVCAP--------------CHASCAT-CQGPALTDCLSC 662
TEN +T+ +VCA CH CA C GP TDC +C
Sbjct: 201 TENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFAC 249
>gi|4885215 v-erb-a erythroblastic leukemia viral oncogene homolog 4
isoform JM-a/CVT-1 precursor [Homo sapiens]
Length = 1308
Score = 33.5 bits (75), Expect = 0.79
Identities = 18/49 (36%), Positives = 22/49 (44%), Gaps = 15/49 (30%)
Query: 629 TENDVETIRASVCAP--------------CHASCAT-CQGPALTDCLSC 662
TEN +T+ +VCA CH CA C GP TDC +C
Sbjct: 201 TENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFAC 249
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.132 0.414
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,387,138
Number of Sequences: 37866
Number of extensions: 1682901
Number of successful extensions: 5920
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 41
Number of HSP's successfully gapped in prelim test: 30
Number of HSP's that attempted gapping in prelim test: 5666
Number of HSP's gapped (non-prelim): 185
length of query: 794
length of database: 18,247,518
effective HSP length: 110
effective length of query: 684
effective length of database: 14,082,258
effective search space: 9632264472
effective search space used: 9632264472
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.