Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 4505317
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4505317 protein phosphatase 1, regulatory (inhibitor)
subunit 12A isoform a [Homo sapiens]
(1030 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|219842212 protein phosphatase 1, regulatory (inhibitor) subun... 2005 0.0
gi|4505317 protein phosphatase 1, regulatory (inhibitor) subunit... 2005 0.0
gi|219842214 protein phosphatase 1, regulatory (inhibitor) subun... 1831 0.0
gi|4505319 protein phosphatase 1, regulatory (inhibitor) subunit... 869 0.0
gi|14195601 protein phosphatase 1, regulatory (inhibitor) subuni... 840 0.0
gi|14149716 protein phosphatase 1, regulatory subunit 12C [Homo ... 360 5e-99
gi|14249672 protein phosphatase 1, regulatory (inhibitor) subuni... 197 4e-50
gi|14195597 protein phosphatase 1, regulatory (inhibitor) subuni... 194 5e-49
gi|28626517 protein phosphatase 1 regulatory inhibitor subunit 1... 189 9e-48
gi|14195599 protein phosphatase 1, regulatory (inhibitor) subuni... 165 2e-40
gi|62177127 myosin heavy chain Myr 8 [Homo sapiens] 137 5e-32
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 110 9e-24
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 110 9e-24
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 109 2e-23
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 108 2e-23
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 108 2e-23
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 107 6e-23
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 107 6e-23
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 107 8e-23
gi|18079216 CASK interacting protein 1 [Homo sapiens] 106 1e-22
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 105 2e-22
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 105 2e-22
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 103 8e-22
gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens] 103 1e-21
gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens] 103 1e-21
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 103 1e-21
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 102 1e-21
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 102 1e-21
gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo ... 101 3e-21
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 101 3e-21
>gi|219842212 protein phosphatase 1, regulatory (inhibitor) subunit
12A isoform a [Homo sapiens]
Length = 1030
Score = 2005 bits (5195), Expect = 0.0
Identities = 1030/1030 (100%), Positives = 1030/1030 (100%)
Query: 1 MKMADAKQKRNEQLKRWIGSETDLEPPVVKRQKTKVKFDDGAVFLAACSSGDTDEVLKLL 60
MKMADAKQKRNEQLKRWIGSETDLEPPVVKRQKTKVKFDDGAVFLAACSSGDTDEVLKLL
Sbjct: 1 MKMADAKQKRNEQLKRWIGSETDLEPPVVKRQKTKVKFDDGAVFLAACSSGDTDEVLKLL 60
Query: 61 HRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLD 120
HRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLD
Sbjct: 61 HRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLD 120
Query: 121 IAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRD 180
IAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRD
Sbjct: 121 IAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRD 180
Query: 181 ARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAA 240
ARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAA
Sbjct: 181 ARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAA 240
Query: 241 HWGKEEACRILVDNLCDMEMVNKVGQTAFDVADEDILGYLEELQKKQNLLHSEKRDKKSP 300
HWGKEEACRILVDNLCDMEMVNKVGQTAFDVADEDILGYLEELQKKQNLLHSEKRDKKSP
Sbjct: 241 HWGKEEACRILVDNLCDMEMVNKVGQTAFDVADEDILGYLEELQKKQNLLHSEKRDKKSP 300
Query: 301 LIESTANMDNNQSQKTFKNKETLIIEPEKNASRIESLEQEKVDEEEEGKKDESSCSSEED 360
LIESTANMDNNQSQKTFKNKETLIIEPEKNASRIESLEQEKVDEEEEGKKDESSCSSEED
Sbjct: 301 LIESTANMDNNQSQKTFKNKETLIIEPEKNASRIESLEQEKVDEEEEGKKDESSCSSEED 360
Query: 361 EEDDSESEAETDKTKPLASVTNANTSSTQAAPVAVTTPTVSSGQATPTSPIKKFPTTATK 420
EEDDSESEAETDKTKPLASVTNANTSSTQAAPVAVTTPTVSSGQATPTSPIKKFPTTATK
Sbjct: 361 EEDDSESEAETDKTKPLASVTNANTSSTQAAPVAVTTPTVSSGQATPTSPIKKFPTTATK 420
Query: 421 ISPKEEERKDESPATWRLGLRKTGSYGALAEITASKEGQKEKDTAGVTRSASSPRLSSSL 480
ISPKEEERKDESPATWRLGLRKTGSYGALAEITASKEGQKEKDTAGVTRSASSPRLSSSL
Sbjct: 421 ISPKEEERKDESPATWRLGLRKTGSYGALAEITASKEGQKEKDTAGVTRSASSPRLSSSL 480
Query: 481 DNKEKEKDSKGTRLAYVAPTIPRRLASTSDIEEKENRDSSSLRTSSSYTRRKWEDDLKKN 540
DNKEKEKDSKGTRLAYVAPTIPRRLASTSDIEEKENRDSSSLRTSSSYTRRKWEDDLKKN
Sbjct: 481 DNKEKEKDSKGTRLAYVAPTIPRRLASTSDIEEKENRDSSSLRTSSSYTRRKWEDDLKKN 540
Query: 541 SSVNEGSTYHKSCSFGRRQDDLISSSVPSTTSTPTVTSAAGLQKSLLSSTSTTTKITTGS 600
SSVNEGSTYHKSCSFGRRQDDLISSSVPSTTSTPTVTSAAGLQKSLLSSTSTTTKITTGS
Sbjct: 541 SSVNEGSTYHKSCSFGRRQDDLISSSVPSTTSTPTVTSAAGLQKSLLSSTSTTTKITTGS 600
Query: 601 SSAGTQSSTSNRLWAEDSTEKEKDSVPTAVTIPVAPTVVNAAASTTTLTTTTAGTVSSTT 660
SSAGTQSSTSNRLWAEDSTEKEKDSVPTAVTIPVAPTVVNAAASTTTLTTTTAGTVSSTT
Sbjct: 601 SSAGTQSSTSNRLWAEDSTEKEKDSVPTAVTIPVAPTVVNAAASTTTLTTTTAGTVSSTT 660
Query: 661 EVRERRRSYLTPVRDEESESQRKARSRQARQSRRSTQGVTLTDLQEAEKTIGRSRSTRTR 720
EVRERRRSYLTPVRDEESESQRKARSRQARQSRRSTQGVTLTDLQEAEKTIGRSRSTRTR
Sbjct: 661 EVRERRRSYLTPVRDEESESQRKARSRQARQSRRSTQGVTLTDLQEAEKTIGRSRSTRTR 720
Query: 721 EQENEEKEKEEKEKQDKEKQEEKKESETSREDEYKQKYSRTYDETYQRYRPVSTSSSTTP 780
EQENEEKEKEEKEKQDKEKQEEKKESETSREDEYKQKYSRTYDETYQRYRPVSTSSSTTP
Sbjct: 721 EQENEEKEKEEKEKQDKEKQEEKKESETSREDEYKQKYSRTYDETYQRYRPVSTSSSTTP 780
Query: 781 SSSLSTMSSSLYASSQLNRPNSLVGITSAYSRGITKENEREGEKREEEKEGEDKSQPKSI 840
SSSLSTMSSSLYASSQLNRPNSLVGITSAYSRGITKENEREGEKREEEKEGEDKSQPKSI
Sbjct: 781 SSSLSTMSSSLYASSQLNRPNSLVGITSAYSRGITKENEREGEKREEEKEGEDKSQPKSI 840
Query: 841 RERRRPREKRRSTGVSFWTQDSDENEQEQQSDTEEGSNKKETQTDSISRYETSSTSAGDR 900
RERRRPREKRRSTGVSFWTQDSDENEQEQQSDTEEGSNKKETQTDSISRYETSSTSAGDR
Sbjct: 841 RERRRPREKRRSTGVSFWTQDSDENEQEQQSDTEEGSNKKETQTDSISRYETSSTSAGDR 900
Query: 901 YDSLLGRSGSYSYLEERKPYSSRLEKDDSTDFKKLYEQILAENEKLKAQLHDTNMELTDL 960
YDSLLGRSGSYSYLEERKPYSSRLEKDDSTDFKKLYEQILAENEKLKAQLHDTNMELTDL
Sbjct: 901 YDSLLGRSGSYSYLEERKPYSSRLEKDDSTDFKKLYEQILAENEKLKAQLHDTNMELTDL 960
Query: 961 KLQLEKATQRQERFADRSLLEMEKRERRALERRISEMEEELKMLPDLKADNQRLKDENGA 1020
KLQLEKATQRQERFADRSLLEMEKRERRALERRISEMEEELKMLPDLKADNQRLKDENGA
Sbjct: 961 KLQLEKATQRQERFADRSLLEMEKRERRALERRISEMEEELKMLPDLKADNQRLKDENGA 1020
Query: 1021 LIRVISKLSK 1030
LIRVISKLSK
Sbjct: 1021 LIRVISKLSK 1030
>gi|4505317 protein phosphatase 1, regulatory (inhibitor) subunit 12A
isoform a [Homo sapiens]
Length = 1030
Score = 2005 bits (5195), Expect = 0.0
Identities = 1030/1030 (100%), Positives = 1030/1030 (100%)
Query: 1 MKMADAKQKRNEQLKRWIGSETDLEPPVVKRQKTKVKFDDGAVFLAACSSGDTDEVLKLL 60
MKMADAKQKRNEQLKRWIGSETDLEPPVVKRQKTKVKFDDGAVFLAACSSGDTDEVLKLL
Sbjct: 1 MKMADAKQKRNEQLKRWIGSETDLEPPVVKRQKTKVKFDDGAVFLAACSSGDTDEVLKLL 60
Query: 61 HRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLD 120
HRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLD
Sbjct: 61 HRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLD 120
Query: 121 IAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRD 180
IAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRD
Sbjct: 121 IAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRD 180
Query: 181 ARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAA 240
ARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAA
Sbjct: 181 ARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAA 240
Query: 241 HWGKEEACRILVDNLCDMEMVNKVGQTAFDVADEDILGYLEELQKKQNLLHSEKRDKKSP 300
HWGKEEACRILVDNLCDMEMVNKVGQTAFDVADEDILGYLEELQKKQNLLHSEKRDKKSP
Sbjct: 241 HWGKEEACRILVDNLCDMEMVNKVGQTAFDVADEDILGYLEELQKKQNLLHSEKRDKKSP 300
Query: 301 LIESTANMDNNQSQKTFKNKETLIIEPEKNASRIESLEQEKVDEEEEGKKDESSCSSEED 360
LIESTANMDNNQSQKTFKNKETLIIEPEKNASRIESLEQEKVDEEEEGKKDESSCSSEED
Sbjct: 301 LIESTANMDNNQSQKTFKNKETLIIEPEKNASRIESLEQEKVDEEEEGKKDESSCSSEED 360
Query: 361 EEDDSESEAETDKTKPLASVTNANTSSTQAAPVAVTTPTVSSGQATPTSPIKKFPTTATK 420
EEDDSESEAETDKTKPLASVTNANTSSTQAAPVAVTTPTVSSGQATPTSPIKKFPTTATK
Sbjct: 361 EEDDSESEAETDKTKPLASVTNANTSSTQAAPVAVTTPTVSSGQATPTSPIKKFPTTATK 420
Query: 421 ISPKEEERKDESPATWRLGLRKTGSYGALAEITASKEGQKEKDTAGVTRSASSPRLSSSL 480
ISPKEEERKDESPATWRLGLRKTGSYGALAEITASKEGQKEKDTAGVTRSASSPRLSSSL
Sbjct: 421 ISPKEEERKDESPATWRLGLRKTGSYGALAEITASKEGQKEKDTAGVTRSASSPRLSSSL 480
Query: 481 DNKEKEKDSKGTRLAYVAPTIPRRLASTSDIEEKENRDSSSLRTSSSYTRRKWEDDLKKN 540
DNKEKEKDSKGTRLAYVAPTIPRRLASTSDIEEKENRDSSSLRTSSSYTRRKWEDDLKKN
Sbjct: 481 DNKEKEKDSKGTRLAYVAPTIPRRLASTSDIEEKENRDSSSLRTSSSYTRRKWEDDLKKN 540
Query: 541 SSVNEGSTYHKSCSFGRRQDDLISSSVPSTTSTPTVTSAAGLQKSLLSSTSTTTKITTGS 600
SSVNEGSTYHKSCSFGRRQDDLISSSVPSTTSTPTVTSAAGLQKSLLSSTSTTTKITTGS
Sbjct: 541 SSVNEGSTYHKSCSFGRRQDDLISSSVPSTTSTPTVTSAAGLQKSLLSSTSTTTKITTGS 600
Query: 601 SSAGTQSSTSNRLWAEDSTEKEKDSVPTAVTIPVAPTVVNAAASTTTLTTTTAGTVSSTT 660
SSAGTQSSTSNRLWAEDSTEKEKDSVPTAVTIPVAPTVVNAAASTTTLTTTTAGTVSSTT
Sbjct: 601 SSAGTQSSTSNRLWAEDSTEKEKDSVPTAVTIPVAPTVVNAAASTTTLTTTTAGTVSSTT 660
Query: 661 EVRERRRSYLTPVRDEESESQRKARSRQARQSRRSTQGVTLTDLQEAEKTIGRSRSTRTR 720
EVRERRRSYLTPVRDEESESQRKARSRQARQSRRSTQGVTLTDLQEAEKTIGRSRSTRTR
Sbjct: 661 EVRERRRSYLTPVRDEESESQRKARSRQARQSRRSTQGVTLTDLQEAEKTIGRSRSTRTR 720
Query: 721 EQENEEKEKEEKEKQDKEKQEEKKESETSREDEYKQKYSRTYDETYQRYRPVSTSSSTTP 780
EQENEEKEKEEKEKQDKEKQEEKKESETSREDEYKQKYSRTYDETYQRYRPVSTSSSTTP
Sbjct: 721 EQENEEKEKEEKEKQDKEKQEEKKESETSREDEYKQKYSRTYDETYQRYRPVSTSSSTTP 780
Query: 781 SSSLSTMSSSLYASSQLNRPNSLVGITSAYSRGITKENEREGEKREEEKEGEDKSQPKSI 840
SSSLSTMSSSLYASSQLNRPNSLVGITSAYSRGITKENEREGEKREEEKEGEDKSQPKSI
Sbjct: 781 SSSLSTMSSSLYASSQLNRPNSLVGITSAYSRGITKENEREGEKREEEKEGEDKSQPKSI 840
Query: 841 RERRRPREKRRSTGVSFWTQDSDENEQEQQSDTEEGSNKKETQTDSISRYETSSTSAGDR 900
RERRRPREKRRSTGVSFWTQDSDENEQEQQSDTEEGSNKKETQTDSISRYETSSTSAGDR
Sbjct: 841 RERRRPREKRRSTGVSFWTQDSDENEQEQQSDTEEGSNKKETQTDSISRYETSSTSAGDR 900
Query: 901 YDSLLGRSGSYSYLEERKPYSSRLEKDDSTDFKKLYEQILAENEKLKAQLHDTNMELTDL 960
YDSLLGRSGSYSYLEERKPYSSRLEKDDSTDFKKLYEQILAENEKLKAQLHDTNMELTDL
Sbjct: 901 YDSLLGRSGSYSYLEERKPYSSRLEKDDSTDFKKLYEQILAENEKLKAQLHDTNMELTDL 960
Query: 961 KLQLEKATQRQERFADRSLLEMEKRERRALERRISEMEEELKMLPDLKADNQRLKDENGA 1020
KLQLEKATQRQERFADRSLLEMEKRERRALERRISEMEEELKMLPDLKADNQRLKDENGA
Sbjct: 961 KLQLEKATQRQERFADRSLLEMEKRERRALERRISEMEEELKMLPDLKADNQRLKDENGA 1020
Query: 1021 LIRVISKLSK 1030
LIRVISKLSK
Sbjct: 1021 LIRVISKLSK 1030
>gi|219842214 protein phosphatase 1, regulatory (inhibitor) subunit
12A isoform b [Homo sapiens]
Length = 943
Score = 1831 bits (4742), Expect = 0.0
Identities = 943/943 (100%), Positives = 943/943 (100%)
Query: 88 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 147
MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE
Sbjct: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
Query: 148 EEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAA 207
EEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAA
Sbjct: 61 EEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAA 120
Query: 208 AKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQT 267
AKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQT
Sbjct: 121 AKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQT 180
Query: 268 AFDVADEDILGYLEELQKKQNLLHSEKRDKKSPLIESTANMDNNQSQKTFKNKETLIIEP 327
AFDVADEDILGYLEELQKKQNLLHSEKRDKKSPLIESTANMDNNQSQKTFKNKETLIIEP
Sbjct: 181 AFDVADEDILGYLEELQKKQNLLHSEKRDKKSPLIESTANMDNNQSQKTFKNKETLIIEP 240
Query: 328 EKNASRIESLEQEKVDEEEEGKKDESSCSSEEDEEDDSESEAETDKTKPLASVTNANTSS 387
EKNASRIESLEQEKVDEEEEGKKDESSCSSEEDEEDDSESEAETDKTKPLASVTNANTSS
Sbjct: 241 EKNASRIESLEQEKVDEEEEGKKDESSCSSEEDEEDDSESEAETDKTKPLASVTNANTSS 300
Query: 388 TQAAPVAVTTPTVSSGQATPTSPIKKFPTTATKISPKEEERKDESPATWRLGLRKTGSYG 447
TQAAPVAVTTPTVSSGQATPTSPIKKFPTTATKISPKEEERKDESPATWRLGLRKTGSYG
Sbjct: 301 TQAAPVAVTTPTVSSGQATPTSPIKKFPTTATKISPKEEERKDESPATWRLGLRKTGSYG 360
Query: 448 ALAEITASKEGQKEKDTAGVTRSASSPRLSSSLDNKEKEKDSKGTRLAYVAPTIPRRLAS 507
ALAEITASKEGQKEKDTAGVTRSASSPRLSSSLDNKEKEKDSKGTRLAYVAPTIPRRLAS
Sbjct: 361 ALAEITASKEGQKEKDTAGVTRSASSPRLSSSLDNKEKEKDSKGTRLAYVAPTIPRRLAS 420
Query: 508 TSDIEEKENRDSSSLRTSSSYTRRKWEDDLKKNSSVNEGSTYHKSCSFGRRQDDLISSSV 567
TSDIEEKENRDSSSLRTSSSYTRRKWEDDLKKNSSVNEGSTYHKSCSFGRRQDDLISSSV
Sbjct: 421 TSDIEEKENRDSSSLRTSSSYTRRKWEDDLKKNSSVNEGSTYHKSCSFGRRQDDLISSSV 480
Query: 568 PSTTSTPTVTSAAGLQKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVP 627
PSTTSTPTVTSAAGLQKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVP
Sbjct: 481 PSTTSTPTVTSAAGLQKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVP 540
Query: 628 TAVTIPVAPTVVNAAASTTTLTTTTAGTVSSTTEVRERRRSYLTPVRDEESESQRKARSR 687
TAVTIPVAPTVVNAAASTTTLTTTTAGTVSSTTEVRERRRSYLTPVRDEESESQRKARSR
Sbjct: 541 TAVTIPVAPTVVNAAASTTTLTTTTAGTVSSTTEVRERRRSYLTPVRDEESESQRKARSR 600
Query: 688 QARQSRRSTQGVTLTDLQEAEKTIGRSRSTRTREQENEEKEKEEKEKQDKEKQEEKKESE 747
QARQSRRSTQGVTLTDLQEAEKTIGRSRSTRTREQENEEKEKEEKEKQDKEKQEEKKESE
Sbjct: 601 QARQSRRSTQGVTLTDLQEAEKTIGRSRSTRTREQENEEKEKEEKEKQDKEKQEEKKESE 660
Query: 748 TSREDEYKQKYSRTYDETYQRYRPVSTSSSTTPSSSLSTMSSSLYASSQLNRPNSLVGIT 807
TSREDEYKQKYSRTYDETYQRYRPVSTSSSTTPSSSLSTMSSSLYASSQLNRPNSLVGIT
Sbjct: 661 TSREDEYKQKYSRTYDETYQRYRPVSTSSSTTPSSSLSTMSSSLYASSQLNRPNSLVGIT 720
Query: 808 SAYSRGITKENEREGEKREEEKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQ 867
SAYSRGITKENEREGEKREEEKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQ
Sbjct: 721 SAYSRGITKENEREGEKREEEKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQ 780
Query: 868 EQQSDTEEGSNKKETQTDSISRYETSSTSAGDRYDSLLGRSGSYSYLEERKPYSSRLEKD 927
EQQSDTEEGSNKKETQTDSISRYETSSTSAGDRYDSLLGRSGSYSYLEERKPYSSRLEKD
Sbjct: 781 EQQSDTEEGSNKKETQTDSISRYETSSTSAGDRYDSLLGRSGSYSYLEERKPYSSRLEKD 840
Query: 928 DSTDFKKLYEQILAENEKLKAQLHDTNMELTDLKLQLEKATQRQERFADRSLLEMEKRER 987
DSTDFKKLYEQILAENEKLKAQLHDTNMELTDLKLQLEKATQRQERFADRSLLEMEKRER
Sbjct: 841 DSTDFKKLYEQILAENEKLKAQLHDTNMELTDLKLQLEKATQRQERFADRSLLEMEKRER 900
Query: 988 RALERRISEMEEELKMLPDLKADNQRLKDENGALIRVISKLSK 1030
RALERRISEMEEELKMLPDLKADNQRLKDENGALIRVISKLSK
Sbjct: 901 RALERRISEMEEELKMLPDLKADNQRLKDENGALIRVISKLSK 943
Score = 33.5 bits (75), Expect = 1.1
Identities = 22/82 (26%), Positives = 35/82 (42%), Gaps = 2/82 (2%)
Query: 41 GAVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANIN 100
G A + G T+ + L+ G D+N + DG T LH A + + LV+N ++
Sbjct: 113 GTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDME 172
Query: 101 QPDNEGWIPLHAAAS--CGYLD 120
+ G A GYL+
Sbjct: 173 MVNKVGQTAFDVADEDILGYLE 194
>gi|4505319 protein phosphatase 1, regulatory (inhibitor) subunit 12B
isoform a [Homo sapiens]
Length = 982
Score = 869 bits (2245), Expect = 0.0
Identities = 518/1053 (49%), Positives = 678/1053 (64%), Gaps = 113/1053 (10%)
Query: 6 AKQKRNEQLKRWIGSETDLEP---------PVVKRQKTKVKFDDGAVFLAACSSGDTDEV 56
A+ +R EQL+RW GS T+ EP P+ +R +V+F+DGAVFLAACSSGDTDEV
Sbjct: 15 ARMRRAEQLRRWRGSLTEQEPAERRGAGRQPLTRRGSPRVRFEDGAVFLAACSSGDTDEV 74
Query: 57 LKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASC 116
KLL RGADIN NVDGLTALHQACID+N+DMVKFLVEN AN+NQ DNEGW PLHAAASC
Sbjct: 75 RKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASC 134
Query: 117 GYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERI 176
GYL+IAE+ I GA VG VNSEG+ P D+AEE AM++LL +V +QG+D+E +RKEEE+
Sbjct: 135 GYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSRKEEEQQ 194
Query: 177 MLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPL 236
ML+DARQWLNSG I DVR A+SG TALHVAAAKGY+EVL+LLIQAGY++N++DYDGWTPL
Sbjct: 195 MLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPL 254
Query: 237 HAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVADEDILGYLEELQKKQNLLHSEKRD 296
HAAAHWG +EAC IL + LCDM++ NK+GQT FDVADE ++ +LE LQKKQN+L SEK +
Sbjct: 255 HAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLELLQKKQNVLRSEK-E 313
Query: 297 KKSPLIESTANMDNNQSQKTFKNKETLIIEPEKNASRIESLEQEKVDEEEEGKKDESSCS 356
++ LIES ++++ FKNKE ++ E E K E EE K+ SS S
Sbjct: 314 TRNKLIES--DLNSKIQSGFFKNKEKMLYEE----------ETPKSQEMEEENKESSSSS 361
Query: 357 SEEDEEDDSESEAETDK---TKPLASVTNANTSSTQAAPVAVTTPTVSSGQATPTSPIKK 413
SEE+E +D SE+ET+K KP A V ++N+ S + + P ++ A S ++
Sbjct: 362 SEEEEGEDEASESETEKEADKKPEAFVNHSNSESKSSITEQIPAPAQNTFSA---SSARR 418
Query: 414 FPTTATKISPKEEERKDESPATWRLGLRKTGSYGALAEITASKEGQKEKDTAGVTRSASS 473
F ++ + K EE KDESP++WRLGLRKTGS+ L+E+ S+E +++ ++ + RS+SS
Sbjct: 419 F---SSGLFNKPEEPKDESPSSWRLGLRKTGSHNMLSEVANSREPIRDRGSS-IYRSSSS 474
Query: 474 PRLSSSLDNKEKEKDSKGTRLAYVAPTIPRRLASTSDIEEKENRDSS-SLRTSSSYTRRK 532
PR+S+ LDNK+KE+++K +Y++ PR+L STSDIEEKENR+S+ +L S SYTR+
Sbjct: 475 PRISALLDNKDKERENK----SYISSLAPRKLNSTSDIEEKENRESAVNLVRSGSYTRQL 530
Query: 533 WEDDLKKNSSVNEGSTYHKSCSFGRRQDDLISSSVPSTTSTPTVTSAAGLQKSLLSSTST 592
W D+ K N +P T + T ST
Sbjct: 531 WRDEAKGN-------------------------EIPQTIAPSTY-------------VST 552
Query: 593 TTKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVPTAV-TIPVAPTVVNAAASTTTLTTT 651
K T S A T AE + + S P V T P+ N +T L+ T
Sbjct: 553 YLKRTPHKSQADTT--------AEKTADNVSSSTPLCVITNRPLPSTANGVTATPVLSIT 604
Query: 652 TAGTVSSTTEVRERRRSYLTPVRDEESESQRKARSRQARQSRRSTQGVTLTDLQEAEKTI 711
GT S+ E RE+RRSYLTPVRDEE+ES RKARSRQARQ+RRSTQGVTLTDLQEAE+T
Sbjct: 605 --GT-DSSVEAREKRRSYLTPVRDEEAESLRKARSRQARQTRRSTQGVTLTDLQEAERTF 661
Query: 712 GRSRSTRTREQENEEKEKEEKEKQDKEKQEEKKESETSREDEYKQKYSRTYDETYQRYR- 770
RSR+ R +++ EK + + + ++ E + E +Q + R+ DE +R
Sbjct: 662 SRSRAERQAQEQPREKPTDTEGLEGSPEKHEPSAVPATEAGEGQQPWGRSLDEEPICHRL 721
Query: 771 --PVSTSSSTTPSSSLSTMSSSLYASSQL---NRPNSLVGITSAYSRGITKENEREGEKR 825
P TTP+S ST SLY SS L NR + +S + T E + +
Sbjct: 722 RCPAQPDKPTTPASP-STSRPSLYTSSHLLWTNRFSVPDSESSETTTNTTTAKEMDKNEN 780
Query: 826 EEEKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQEQQSDTEEGSNKKETQTD 885
EE E S+ SIRERRRP+E+RR TG++FWT+D DE T+ KET +
Sbjct: 781 EEADLDEQSSKRLSIRERRRPKERRRGTGINFWTKDEDE--------TDGSEEVKETWHE 832
Query: 886 SISRYE------TSSTSAGDRYDSLLGRSGSYSYLEERKPYSSRLEKDDSTDFKKLYEQI 939
+SR E T+S S GDR + R + L +SR+E+D + D+KKLYE
Sbjct: 833 RLSRLESGGSNPTTSDSYGDRASARARREAREARL---ATLTSRVEEDSNRDYKKLYESA 889
Query: 940 LAENEKLKAQLHDTNMELTDLKLQLEK-ATQRQERFADR-SLLEMEKRERRALERRISEM 997
L EN+KLK +L + +EL D+K +LEK A Q+QE+ +DR S+LEMEKRERRALER++SEM
Sbjct: 890 LTENQKLKTKLQEAQLELADIKSKLEKVAQQKQEKTSDRSSVLEMEKRERRALERKMSEM 949
Query: 998 EEELKMLPDLKADNQRLKDENGALIRVISKLSK 1030
EEE+K+L +LK+DNQRLKDENGALIRVISKLSK
Sbjct: 950 EEEMKVLTELKSDNQRLKDENGALIRVISKLSK 982
>gi|14195601 protein phosphatase 1, regulatory (inhibitor) subunit 12B
isoform b [Homo sapiens]
Length = 998
Score = 840 bits (2170), Expect = 0.0
Identities = 507/1059 (47%), Positives = 671/1059 (63%), Gaps = 119/1059 (11%)
Query: 6 AKQKRNEQLKRWIGSETDLEP---------PVVKRQKTKVKFDDGAVFLAACSSGDTDEV 56
A+ +R EQL+RW GS T+ EP P+ +R +V+F+DGAVFLAACSSGDTDEV
Sbjct: 15 ARMRRAEQLRRWRGSLTEQEPAERRGAGRQPLTRRGSPRVRFEDGAVFLAACSSGDTDEV 74
Query: 57 LKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASC 116
KLL RGADIN NVDGLTALHQACID+N+DMVKFLVEN AN+NQ DNEGW PLHAAASC
Sbjct: 75 RKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASC 134
Query: 117 GYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERI 176
GYL+IAE+ I GA VG VNSEG+ P D+AEE AM++LL +V +QG+D+E +RKEEE+
Sbjct: 135 GYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSRKEEEQQ 194
Query: 177 MLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPL 236
ML+DARQWLNSG I DVR A+SG TALHVAAAKGY+EVL+LLIQAGY++N++DYDGWTPL
Sbjct: 195 MLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPL 254
Query: 237 HAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVADEDILGYLEELQKKQNLLHSEKRD 296
HAAAHWG +EAC IL + LCDM++ NK+GQT FDVADE ++ +LE LQKKQN+L SEK +
Sbjct: 255 HAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLELLQKKQNVLRSEK-E 313
Query: 297 KKSPLIESTANMDNNQSQKTFKNKETLIIEPEKNASRIESLEQEKVDEEEEGKKDESSCS 356
++ LIES ++++ FKNKE ++ E E K E EE K+ SS S
Sbjct: 314 TRNKLIES--DLNSKIQSGFFKNKEKMLYEE----------ETPKSQEMEEENKESSSSS 361
Query: 357 SEEDEEDDSESEAETDK---TKPLASVTNANTSSTQAAPVAVTTPTVSSGQATPTSPIKK 413
SEE+E +D SE+ET+K KP A V ++N+ S + + P ++ A S ++
Sbjct: 362 SEEEEGEDEASESETEKEADKKPEAFVNHSNSESKSSITEQIPAPAQNTFSA---SSARR 418
Query: 414 FPTTATKISPKEEERKDESPATWRLGLRKTGSYGALAEITASKEGQKEKDTAGVTRSASS 473
F ++ + K EE KDESP++WRLGLRKTGS+ L+E+ S+E +++ ++ + RS+SS
Sbjct: 419 F---SSGLFNKPEEPKDESPSSWRLGLRKTGSHNMLSEVANSREPIRDRGSS-IYRSSSS 474
Query: 474 PRLSSSLDNKEKEKDSKGTRLAYVAPTIPRRLASTSDIEEKENRDSS-SLRTSSSYTRRK 532
PR+S+ LDNK+KE+++K +Y++ PR+L STSDIEEKENR+S+ +L S SYTR+
Sbjct: 475 PRISALLDNKDKERENK----SYISSLAPRKLNSTSDIEEKENRESAVNLVRSGSYTRQL 530
Query: 533 WEDDLKKNSSVNEGSTYHKSCSFGRRQDDLISSSVPSTTSTPTVTSAAGLQKSLLSSTST 592
W D+ K N +P T + T ST
Sbjct: 531 WRDEAKGN-------------------------EIPQTIAPSTY-------------VST 552
Query: 593 TTKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVPTAV-TIPVAPTVVNAAASTTTLTTT 651
K T S A T AE + + S P V T P+ N +T L+ T
Sbjct: 553 YLKRTPHKSQADTT--------AEKTADNVSSSTPLCVITNRPLPSTANGVTATPVLSIT 604
Query: 652 TAGTVSSTTEVRERRRSYLTPVRDEESESQRKARSRQARQSRRSTQGVTLTDLQEAEKTI 711
GT S+ E RE+RRSYLTPVRDEE+ES RKARSRQARQ+RRSTQGVTLTDLQEAE+T
Sbjct: 605 --GT-DSSVEAREKRRSYLTPVRDEEAESLRKARSRQARQTRRSTQGVTLTDLQEAERTF 661
Query: 712 GRSRSTRTREQENEEKEKEEKEKQDKEKQEEKKESETSREDEYKQKYSRTYDETYQRYR- 770
RSR+ R +++ EK + + + ++ E + E +Q + R+ DE +R
Sbjct: 662 SRSRAERQAQEQPREKPTDTEGLEGSPEKHEPSAVPATEAGEGQQPWGRSLDEEPICHRL 721
Query: 771 --PVSTSSSTTPSSSLSTMSSSLYASSQL---NRPNSLVGITSAYSRGITKENEREGEKR 825
P TTP+S ST SLY SS L NR + +S + T E + +
Sbjct: 722 RCPAQPDKPTTPASP-STSRPSLYTSSHLLWTNRFSVPDSESSETTTNTTTAKEMDKNEN 780
Query: 826 EEEKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQEQQSDTEEGSNKKETQTD 885
EE E S+ SIRERRRP+E+RR TG++FWT+D DE T+ KET +
Sbjct: 781 EEADLDEQSSKRLSIRERRRPKERRRGTGINFWTKDEDE--------TDGSEEVKETWHE 832
Query: 886 SISRYE------TSSTSAGDRYDSLLGRSGSYSYLEERKPYSSRLEKDDSTDFKKLYEQI 939
+SR E T+S S GDR + R + L +SR+E+D + D+KKLYE
Sbjct: 833 RLSRLESGGSNPTTSDSYGDRASARARREAREARL---ATLTSRVEEDSNRDYKKLYESA 889
Query: 940 LAENEKLKAQLHDTNMELTDLKLQLEK-ATQRQERFADR-SLLEMEKRERRALERRISEM 997
L EN+KLK +L + +EL D+K +LEK A Q+QE+ +DR S+LEMEKRERRALER++SEM
Sbjct: 890 LTENQKLKTKLQEAQLELADIKSKLEKVAQQKQEKTSDRSSVLEMEKRERRALERKMSEM 949
Query: 998 EEE------LKMLPDLKADNQRLKDENGALIRVISKLSK 1030
EEE LK + LK N++L+ EN AL RV+++LS+
Sbjct: 950 EEEMKNLHQLKQIQTLKQMNEQLQAENRALTRVVARLSE 988
>gi|14149716 protein phosphatase 1, regulatory subunit 12C [Homo
sapiens]
Length = 782
Score = 360 bits (923), Expect = 5e-99
Identities = 265/824 (32%), Positives = 395/824 (47%), Gaps = 109/824 (13%)
Query: 4 ADAKQKRNEQLKRWIGSETDLEPPVVKRQKTKVKFDDGAVFLAACSSGDTDEVLKLLHRG 63
A A+++R EQL++W G+ EP +R+ V+F+ A FLAAC+ GD DE +L+ R
Sbjct: 16 AAARERRREQLRQW-GARAGAEPGPGERRARTVRFERAAEFLAACAGGDLDEA-RLMLRA 73
Query: 64 AD------------------INYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNE 105
AD ++ N DG++ALHQACID+N+++V+FLVE GA +NQ DNE
Sbjct: 74 ADPGPGAELDPAAPPPARAVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNE 133
Query: 106 GWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVD 165
GW PLH AASCGYLDIA +L+ GA++ AVNS+GD PLD+AE +AME LL+ E+ R+GVD
Sbjct: 134 GWTPLHVAASCGYLDIARYLLSHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVD 193
Query: 166 IEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDV 225
+EAA++ EE ++L D R WLN G + + RH ++G +ALHVAAAKGY EV++LL+QAGYD
Sbjct: 194 VEAAKRAEEELLLHDTRCWLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDP 253
Query: 226 NIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVADEDILGYLEELQK 285
++D DGWTPLHAAAHWG E+ACR+L ++ M+ + GQ D+ADE++L LEEL +
Sbjct: 254 ELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGMDSLTHAGQRPCDLADEEVLSLLEELAR 313
Query: 286 KQNLLHSEKRDKKSPLIESTANMDNNQSQKTFKNKETLIIEPEKNASRIESLEQEKVDEE 345
KQ L ++K S + Q+ + K++ + + R+ S +EK+ +
Sbjct: 314 KQEDLRNQKE-------ASQSRGQEPQAPSSSKHRRS-------SVCRLSS--REKISLQ 357
Query: 346 EEGKKDESSCSSEEDEEDDSESEAETDKTKPLASVTNANTSSTQAAPVAVTTPTVSSGQA 405
+ K+ + +D+ E E + P P +G +
Sbjct: 358 DLSKERRPGGAGGPPIQDEDEGEEGPTEPPP-------------------AEPRTLNGVS 398
Query: 406 TPTSPIKKFPTTATKISPKEEERKDESPATWRLGLRKTGSYGALAEITASKEGQKEKDTA 465
+P P SPK + +E+P + R GL KTGS GAL G E+ TA
Sbjct: 399 SPPHP-----------SPKSPVQLEEAPFSRRFGLLKTGSSGAL--------GPPERRTA 439
Query: 466 GVTRSASSPRLSSSLDNKEKEKDSKGTRLAYVAPTIPRRLASTSDIEEKENRDSSSLRTS 525
A R +SS + +K RLA + PT +L S + E + L S
Sbjct: 440 EGAPGAGLQRSASSSWLEGTSTQAKELRLARITPTPSPKLPEPSVLSE-VTKPPPCLENS 498
Query: 526 SSYTRRKWEDDLKKNSSVNEGSTYHKSCSFGRRQDDLISSSVPSTTSTPTVTSAAGLQKS 585
S +R E + +V ST + S RR+ + + S S Q
Sbjct: 499 SPPSRIP-EPESPAKPNVPTASTAPPADSRDRRRSYQMPVRDEESESQRKARSRLMRQSR 557
Query: 586 LLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEK-------DSVPTAVTIP----V 634
+ T T + +AG + + D + + + DS P
Sbjct: 558 RSTQGVTLTDLKEAEKAAGKAPESEKPAQSLDPSRRPRVPGVENSDSPAQRAEAPDGQGP 617
Query: 635 APTVV----------NAAASTTTLTTTTAGTVSSTTE-----VRERRRSYLTPVRDEESE 679
P A SST E R+R + L P + ESE
Sbjct: 618 GPQAAREHRKVGKEWRGPAEGEEAEPADRSQESSTLEGGPSARRQRWQRDLNPEPEPESE 677
Query: 680 SQ----RKARSRQARQSRRSTQGVTLTDLQEAEKTIGRSRSTRTREQENEEK---EKEEK 732
R + R++ R + +T T L+ A+ + R+T+ +E+ E E E
Sbjct: 678 EPDGGFRTLYAELRRENERLREALTETTLRLAQLKVELERATQRQERFAERPALLELERF 737
Query: 733 EKQDKEKQEEKKESETSREDEYKQKYSRTYDETYQRYRPVSTSS 776
E++ E++ + E E + + R DE R +S S
Sbjct: 738 ERRALERKAAELEEELKALSDLRADNQRLKDENAALIRVISKLS 781
Score = 132 bits (333), Expect = 1e-30
Identities = 100/278 (35%), Positives = 146/278 (52%), Gaps = 29/278 (10%)
Query: 772 VSTSSSTTPSSSLSTMSSSLY------ASSQLNRPNSLVGITSAYSRGITKENEREGEKR 825
V T+S+ P+ S S + SQ + L+ + ++G+T + +E EK
Sbjct: 515 VPTASTAPPADSRDRRRSYQMPVRDEESESQRKARSRLMRQSRRSTQGVTLTDLKEAEKA 574
Query: 826 EEEKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQEQQSDTEEGSNKKETQTD 885
K E + +S+ RRPR GV ++SD Q ++ +G + +
Sbjct: 575 AG-KAPESEKPAQSLDPSRRPRVP----GV----ENSDSPAQRAEAPDGQGPGPQAAREH 625
Query: 886 SISRYETSSTSAGDRYDSLLGRSGSYSYLE------------ERKPYSSRLEKDDSTDFK 933
E + G+ + RS S LE + P ++ F+
Sbjct: 626 RKVGKEWRGPAEGEEAEPA-DRSQESSTLEGGPSARRQRWQRDLNPEPEPESEEPDGGFR 684
Query: 934 KLYEQILAENEKLKAQLHDTNMELTDLKLQLEKATQRQERFADR-SLLEMEKRERRALER 992
LY ++ ENE+L+ L +T + L LK++LE+ATQRQERFA+R +LLE+E+ ERRALER
Sbjct: 685 TLYAELRRENERLREALTETTLRLAQLKVELERATQRQERFAERPALLELERFERRALER 744
Query: 993 RISEMEEELKMLPDLKADNQRLKDENGALIRVISKLSK 1030
+ +E+EEELK L DL+ADNQRLKDEN ALIRVISKLSK
Sbjct: 745 KAAELEEELKALSDLRADNQRLKDENAALIRVISKLSK 782
Score = 93.6 bits (231), Expect = 9e-19
Identities = 94/318 (29%), Positives = 125/318 (39%), Gaps = 40/318 (12%)
Query: 568 PSTTSTPTVTSAAGLQKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVP 627
P T AGLQ+S SS T + T + E S E P
Sbjct: 433 PPERRTAEGAPGAGLQRSASSSWLEGTSTQAKELRLARITPTPSPKLPEPSVLSEVTKPP 492
Query: 628 TAVTIPVAPTVVNAAASTTTLTTTTAGTVSSTTEVRERRRSYLTPVRDEESESQRKARSR 687
+ P+ + S TA T + + R+RRRSY PVRDEESESQRKARSR
Sbjct: 493 PCLENSSPPSRIPEPESPAKPNVPTAST-APPADSRDRRRSYQMPVRDEESESQRKARSR 551
Query: 688 QARQSRRSTQGVTLTDLQEAEKTIGR-------------SRSTRTREQENEEKEKEEKEK 734
RQSRRSTQGVTLTDL+EAEK G+ SR R EN + + E
Sbjct: 552 LMRQSRRSTQGVTLTDLKEAEKAAGKAPESEKPAQSLDPSRRPRVPGVENSDSPAQRAEA 611
Query: 735 QD---------KEKQEEKKESETSREDEYKQKYSRTYD------------ETYQR-YRPV 772
D +E ++ KE E E + R+ + + +QR P
Sbjct: 612 PDGQGPGPQAAREHRKVGKEWRGPAEGEEAEPADRSQESSTLEGGPSARRQRWQRDLNPE 671
Query: 773 STSSSTTPSSSLSTMSSSLYASSQLNRPNSLVGITSAYSRGITKENEREGEKREEEKEGE 832
S P T LYA + +T R + E E + +E+ E
Sbjct: 672 PEPESEEPDGGFRT----LYAELRRENERLREALTETTLRLAQLKVELERATQRQERFAE 727
Query: 833 DKSQPKSIRERRRPREKR 850
+ + R RR E++
Sbjct: 728 RPALLELERFERRALERK 745
>gi|14249672 protein phosphatase 1, regulatory (inhibitor) subunit
16A [Homo sapiens]
Length = 528
Score = 197 bits (501), Expect = 4e-50
Identities = 153/469 (32%), Positives = 232/469 (49%), Gaps = 34/469 (7%)
Query: 2 KMADAKQKRNEQLKRWIGSETDLE----PPVVKRQKT-------KVKFDDGAVFLAACSS 50
++ A+++R +Q+K W +E + + P R++ +V F V L A +
Sbjct: 22 RLKHAQKRRAQQVKMWAQAEKEAQGKKGPGERPRKEAASQGLLKQVLFPPSVVLLEAAAR 81
Query: 51 GDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPL 110
D +EV + L G + AN DGLTALHQ CIDD +MV+ L+E GANIN D+E W PL
Sbjct: 82 NDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSECWTPL 141
Query: 111 HAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGV---DIE 167
HAAA+CG+L + E LI GA++ AVN++G+ P D+ ++E + L+ + +G+ IE
Sbjct: 142 HAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRGITQDSIE 201
Query: 168 AARKEEERIMLRDARQWLNSGHINDVRHA--KSGGTALHVAAAKGYTEVLKLLIQAGYDV 225
AAR E ML D R L +G D+ HA G T LHVAAA G++E LL++ +
Sbjct: 202 AARAVPELRMLDDIRSRLQAG--ADL-HAPLDHGATLLHVAAANGFSEAAALLLEHRASL 258
Query: 226 NIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDV-ADEDILGYLEELQ 284
+ KD DGW PLHAAA+WG+ +LV + D+ + + +T DV DE++ L EL+
Sbjct: 259 SAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDVCGDEEVRAKLLELK 318
Query: 285 KKQNLLHSEKRDKKSPLIESTANMDNNQS--QKTFKNKETLIIEPEKNASRIESLEQEKV 342
K + L + ++S L T++ + ++ + T + + I +
Sbjct: 319 HKHDALLRAQSRQRSLLRRRTSSAGSRGKVVRRVSLTQRTDLYRKQHAQEAIVWQQPPPT 378
Query: 343 DEEEEGKKDESSCSSE----EDEEDDSE------SEAETDKTKPLASVTNANTSSTQAAP 392
E D+ +E EED+ E + L S + S Q +P
Sbjct: 379 SPEPPEDNDDRQTGAELRPPPPEEDNPEVVRPHNGRVGGSPVRHLYSKRLDRSVSYQLSP 438
Query: 393 VAVTTP-TVSSGQATPTSPIKKFPTTATKISPKEEERKDESPATWRLGL 440
+ TTP T+ +A T K A K+ E ESP T GL
Sbjct: 439 LDSTTPHTLVHDKAHHTLADLKRQRAAAKLQRPPPE-GPESPETAEPGL 486
>gi|14195597 protein phosphatase 1, regulatory (inhibitor) subunit 12B
isoform c [Homo sapiens]
Length = 208
Score = 194 bits (492), Expect = 5e-49
Identities = 113/215 (52%), Positives = 147/215 (68%), Gaps = 19/215 (8%)
Query: 824 KREEEKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQEQQSDTEEGSNKKETQ 883
+ EE E S+ SIRERRRP+E+RR TG++FWT+D DE T+ KET
Sbjct: 5 ENEEADLDEQSSKRLSIRERRRPKERRRGTGINFWTKDEDE--------TDGSEEVKETW 56
Query: 884 TDSISRYE------TSSTSAGDRYDSLLGRSGSYSYLEERKPYSSRLEKDDSTDFKKLYE 937
+ +SR E T+S S GDR + R + L +SR+E+D + D+KKLYE
Sbjct: 57 HERLSRLESGGSNPTTSDSYGDRASARARREAREARL---ATLTSRVEEDSNRDYKKLYE 113
Query: 938 QILAENEKLKAQLHDTNMELTDLKLQLEK-ATQRQERFADR-SLLEMEKRERRALERRIS 995
L EN+KLK +L + +EL D+K +LEK A Q+QE+ +DR S+LEMEKRERRALER++S
Sbjct: 114 SALTENQKLKTKLQEAQLELADIKSKLEKVAQQKQEKTSDRSSVLEMEKRERRALERKMS 173
Query: 996 EMEEELKMLPDLKADNQRLKDENGALIRVISKLSK 1030
EMEEE+K+L +LK+DNQRLKDENGALIRVISKLSK
Sbjct: 174 EMEEEMKVLTELKSDNQRLKDENGALIRVISKLSK 208
>gi|28626517 protein phosphatase 1 regulatory inhibitor subunit 16B
[Homo sapiens]
Length = 567
Score = 189 bits (481), Expect = 9e-48
Identities = 109/318 (34%), Positives = 174/318 (54%), Gaps = 13/318 (4%)
Query: 2 KMADAKQKRNEQLKRWIGSETDLEPPVVKRQKT--------KVKFDDGAVFLAACSSGDT 53
++ A+++R +QLK+W E DL+ K ++ KV F+ L A D
Sbjct: 22 RLRAAQKRRAQQLKKWAQYEQDLQHRKRKHERKRSTGGRRKKVSFEASVALLEASLRNDA 81
Query: 54 DEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAA 113
+EV L + N DGLTALHQ CID+ ++VK L+ +GAN+N DNE W PLHAA
Sbjct: 82 EEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAA 141
Query: 114 ASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGV---DIEAAR 170
A+CG++++ + L+ GA + AVNS+G+ P D+ E+E ++++ + QG+ I R
Sbjct: 142 ATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQEKINEMR 201
Query: 171 KEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDY 230
E+ M+ D + +G D A+ G T LH+A A GY +LL+ G V++KD+
Sbjct: 202 VAPEQQMIADIHCMIAAGQDLDWIDAQ-GATLLHIAGANGYLRAAELLLDHGVRVDVKDW 260
Query: 231 DGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVA-DEDILGYLEELQKKQNL 289
DGW PLHAAA WG+ + +LV + + + + D+ +E+ L EL+ K ++
Sbjct: 261 DGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLCEEEEFKVLLLELKHKHDV 320
Query: 290 LHSEKRDKKSPLIESTAN 307
+ + KS L T++
Sbjct: 321 IMKSQLRHKSSLSRRTSS 338
>gi|14195599 protein phosphatase 1, regulatory (inhibitor) subunit 12B
isoform d [Homo sapiens]
Length = 224
Score = 165 bits (417), Expect = 2e-40
Identities = 102/221 (46%), Positives = 140/221 (63%), Gaps = 25/221 (11%)
Query: 824 KREEEKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQEQQSDTEEGSNKKETQ 883
+ EE E S+ SIRERRRP+E+RR TG++FWT+D DE T+ KET
Sbjct: 5 ENEEADLDEQSSKRLSIRERRRPKERRRGTGINFWTKDEDE--------TDGSEEVKETW 56
Query: 884 TDSISRYE------TSSTSAGDRYDSLLGRSGSYSYLEERKPYSSRLEKDDSTDFKKLYE 937
+ +SR E T+S S GDR + R + L +SR+E+D + D+KKLYE
Sbjct: 57 HERLSRLESGGSNPTTSDSYGDRASARARREAREARL---ATLTSRVEEDSNRDYKKLYE 113
Query: 938 QILAENEKLKAQLHDTNMELTDLKLQLEK-ATQRQERFADR-SLLEMEKRERRALERRIS 995
L EN+KLK +L + +EL D+K +LEK A Q+QE+ +DR S+LEMEKRERRALER++S
Sbjct: 114 SALTENQKLKTKLQEAQLELADIKSKLEKVAQQKQEKTSDRSSVLEMEKRERRALERKMS 173
Query: 996 EMEEE------LKMLPDLKADNQRLKDENGALIRVISKLSK 1030
EMEEE LK + LK N++L+ EN AL RV+++LS+
Sbjct: 174 EMEEEMKNLHQLKQIQTLKQMNEQLQAENRALTRVVARLSE 214
>gi|62177127 myosin heavy chain Myr 8 [Homo sapiens]
Length = 1858
Score = 137 bits (345), Expect = 5e-32
Identities = 100/310 (32%), Positives = 157/310 (50%), Gaps = 18/310 (5%)
Query: 7 KQKRNEQLKRWIGSETDLEPP--VVKRQK----TKVKFDDGAVFLAACSSGDTDEVLKLL 60
K+ R EQ+K + E + +KR K KV F+ + A + EVL+LL
Sbjct: 21 KRMRCEQIKAYYEREKAFQKQEGFLKRLKHAKNPKVHFNLTDMLQDAIIHHNDKEVLRLL 80
Query: 61 HRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLD 120
GAD + G + LH DN + + L++ G N+N D + W P+H A +C D
Sbjct: 81 KEGADPHTLVSSGGSLLHLCARYDNAFIAEILIDRGVNVNHQDEDFWTPMHIACACDNPD 140
Query: 121 IAEFLIGQGAHVGAVNSEGDTPLDIA-EEEAMEELLQNEVNRQGVDIEAARK---EEERI 176
I L+ GA+V + G+ PLD A E +L ++ GVD+ + R+ +
Sbjct: 141 IVLLLVLAGANVLLQDVNGNIPLDYAVEGTESSSILLTYLDENGVDLTSLRQMKLQRPMS 200
Query: 177 MLRDARQWLNS-GHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTP 235
ML D + +L+S G++N+ G T LH+A A GY EV+ L+++ G D+NI D WTP
Sbjct: 201 MLTDVKHFLSSGGNVNEKN--DEGVTLLHMACASGYKEVVSLILEHGGDLNIVDDQYWTP 258
Query: 236 LHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVADEDILGYLEELQKKQNLLHSEKR 295
LH AA +G+ ++L+ + + +VN + A D+A + ++EE+ K + EK
Sbjct: 259 LHLAAKYGQTNLVKLLLMHQANPHLVNCNEEKASDIAASE---FIEEMLLKAEIAWEEK- 314
Query: 296 DKKSPLIEST 305
K PL ST
Sbjct: 315 -MKEPLSAST 323
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 110 bits (274), Expect = 9e-24
Identities = 88/291 (30%), Positives = 133/291 (45%), Gaps = 53/291 (18%)
Query: 30 KRQKTKVKFDDGAVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNV--- 86
+R+K K D A FL A +G+ D+V++ L G DIN N +GL ALH A + +V
Sbjct: 21 QRRKRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLV 80
Query: 87 ------------------------------DMVKFLVENGANINQPDNEGWIPLHAAASC 116
++VK LV+ GANIN G+ PL+ AA
Sbjct: 81 QELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQE 140
Query: 117 GYLDIAEFLIGQGAHVGAVNSEGDTPLDIA----EEEAMEELLQNE----VNRQGVDIEA 168
++D+ ++L+ GA+ +G TPL +A +A+ LL+N+ V + I A
Sbjct: 141 NHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHI-A 199
Query: 169 ARKEEERIMLRDARQWLNSGHINDV-------RHAKSGGTALHVAAAKGYTEVLKLLIQA 221
ARK++ + A L + H DV R +SG T LH+AA G V LL+
Sbjct: 200 ARKDD----TKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNR 255
Query: 222 GYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVA 272
G V+ +G TPLH A+ G ++L+D ++ + G T A
Sbjct: 256 GAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCA 306
Score = 101 bits (251), Expect = 4e-21
Identities = 79/271 (29%), Positives = 131/271 (48%), Gaps = 25/271 (9%)
Query: 47 ACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEG 106
A G+ + LL+RGA +++ +G+T LH A N +MVK L++ G I+ +G
Sbjct: 240 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDG 299
Query: 107 WIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEE----EAMEELLQNEVNRQ 162
PLH AA G+ + E L+ +GA + A G +PL +A + E ++ LLQ++
Sbjct: 300 LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVD 359
Query: 163 GVDIE-------AARKEEERI--MLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTE 213
V ++ AA R+ +L D R N A +G T LH+A K +
Sbjct: 360 DVTLDYLTALHVAAHCGHYRVTKLLLDKR-------ANPNARALNGFTPLHIACKKNRIK 412
Query: 214 VLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVAD 273
V++LL++ G + G TP+H AA G +L+ N ++ N G+TA +A
Sbjct: 413 VMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAA 472
Query: 274 EDILGYLEE---LQKKQNLLHSEKRDKKSPL 301
G +E L + L+ + R++++PL
Sbjct: 473 R--AGQVEVVRCLLRNGALVDARAREEQTPL 501
Score = 100 bits (248), Expect = 9e-21
Identities = 73/244 (29%), Positives = 112/244 (45%), Gaps = 16/244 (6%)
Query: 47 ACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEG 106
A G D LL R A + A +GLT LH A DN + L+E GA+ + G
Sbjct: 570 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 629
Query: 107 WIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDI 166
+ PLH AA + IA L+ GA V +G TPL +A +E +++ +++ G +I
Sbjct: 630 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDK-GANI 688
Query: 167 EAARK----------EEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLK 216
+ K +E+++ + D L + H K G T L VA G +++
Sbjct: 689 HMSTKSGLTSLHLAAQEDKVNVADI---LTKHGADQDAHTKLGYTPLIVACHYGNVKMVN 745
Query: 217 LLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVADEDI 276
L++ G +VN K +G+TPLH AA G +L+ + G TA +A
Sbjct: 746 FLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKR-- 803
Query: 277 LGYL 280
LGY+
Sbjct: 804 LGYI 807
Score = 92.8 bits (229), Expect = 1e-18
Identities = 70/226 (30%), Positives = 100/226 (44%), Gaps = 27/226 (11%)
Query: 47 ACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEG 106
A G + VL LL GA + N+ G TALH A V++V+ L+ NGA ++ E
Sbjct: 438 AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREE 497
Query: 107 WIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDI 166
PLH A+ G +I + L+ AH A + G TPL I+ E VD+
Sbjct: 498 QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQ------------VDV 545
Query: 167 EAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVN 226
A L +G + + K G T LHVAA G +V KLL+Q +
Sbjct: 546 --------------ASVLLEAGAAHSLA-TKKGFTPLHVAAKYGSLDVAKLLLQRRAAAD 590
Query: 227 IKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVA 272
+G TPLH AAH+ ++ +L++ K G T +A
Sbjct: 591 SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIA 636
Score = 80.9 bits (198), Expect = 6e-15
Identities = 66/222 (29%), Positives = 96/222 (43%), Gaps = 27/222 (12%)
Query: 51 GDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPL 110
G D LL GA + A G T LH A ++D+ K L++ A + G PL
Sbjct: 541 GQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPL 600
Query: 111 HAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAAR 170
H AA +A L+ +GA A G TPL I AA+
Sbjct: 601 HVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHI----------------------AAK 638
Query: 171 KEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDY 230
K + +I A LN G ++ K G T LH+A+ +G+T+++ LL+ G ++++
Sbjct: 639 KNQMQI----ASTLLNYGAETNI-VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTK 693
Query: 231 DGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVA 272
G T LH AA K IL + D + K+G T VA
Sbjct: 694 SGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVA 735
Score = 76.6 bits (187), Expect = 1e-13
Identities = 58/218 (26%), Positives = 94/218 (43%), Gaps = 16/218 (7%)
Query: 66 INYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFL 125
+N G T LH A NV++ L+ GA ++ G PLH A+ G ++ + L
Sbjct: 226 VNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLL 285
Query: 126 IGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWL 185
+ +G + A +G TPL A +++++ + R G + A K L
Sbjct: 286 LDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLER-GAPLLARTKNG----LSPLHMAA 340
Query: 186 NSGHINDVRHAKSGG-----------TALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWT 234
H+ V+H TALHVAA G+ V KLL+ + N + +G+T
Sbjct: 341 QGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFT 400
Query: 235 PLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVA 272
PLH A + + +LV ++ + + G T VA
Sbjct: 401 PLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVA 438
Score = 45.8 bits (107), Expect = 2e-04
Identities = 25/81 (30%), Positives = 40/81 (49%)
Query: 45 LAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDN 104
+ AC G+ V LL +GA++N +G T LHQA + ++ L+++GA N
Sbjct: 733 IVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTA 792
Query: 105 EGWIPLHAAASCGYLDIAEFL 125
G L A GY+ + + L
Sbjct: 793 NGNTALAIAKRLGYISVVDTL 813
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 110 bits (274), Expect = 9e-24
Identities = 88/291 (30%), Positives = 133/291 (45%), Gaps = 53/291 (18%)
Query: 30 KRQKTKVKFDDGAVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNV--- 86
+R+K K D A FL A +G+ D+V++ L G DIN N +GL ALH A + +V
Sbjct: 21 QRRKRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLV 80
Query: 87 ------------------------------DMVKFLVENGANINQPDNEGWIPLHAAASC 116
++VK LV+ GANIN G+ PL+ AA
Sbjct: 81 QELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQE 140
Query: 117 GYLDIAEFLIGQGAHVGAVNSEGDTPLDIA----EEEAMEELLQNE----VNRQGVDIEA 168
++D+ ++L+ GA+ +G TPL +A +A+ LL+N+ V + I A
Sbjct: 141 NHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHI-A 199
Query: 169 ARKEEERIMLRDARQWLNSGHINDV-------RHAKSGGTALHVAAAKGYTEVLKLLIQA 221
ARK++ + A L + H DV R +SG T LH+AA G V LL+
Sbjct: 200 ARKDD----TKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNR 255
Query: 222 GYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVA 272
G V+ +G TPLH A+ G ++L+D ++ + G T A
Sbjct: 256 GAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCA 306
Score = 101 bits (251), Expect = 4e-21
Identities = 79/271 (29%), Positives = 131/271 (48%), Gaps = 25/271 (9%)
Query: 47 ACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEG 106
A G+ + LL+RGA +++ +G+T LH A N +MVK L++ G I+ +G
Sbjct: 240 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDG 299
Query: 107 WIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEE----EAMEELLQNEVNRQ 162
PLH AA G+ + E L+ +GA + A G +PL +A + E ++ LLQ++
Sbjct: 300 LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVD 359
Query: 163 GVDIE-------AARKEEERI--MLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTE 213
V ++ AA R+ +L D R N A +G T LH+A K +
Sbjct: 360 DVTLDYLTALHVAAHCGHYRVTKLLLDKR-------ANPNARALNGFTPLHIACKKNRIK 412
Query: 214 VLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVAD 273
V++LL++ G + G TP+H AA G +L+ N ++ N G+TA +A
Sbjct: 413 VMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAA 472
Query: 274 EDILGYLEE---LQKKQNLLHSEKRDKKSPL 301
G +E L + L+ + R++++PL
Sbjct: 473 R--AGQVEVVRCLLRNGALVDARAREEQTPL 501
Score = 100 bits (248), Expect = 9e-21
Identities = 73/244 (29%), Positives = 112/244 (45%), Gaps = 16/244 (6%)
Query: 47 ACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEG 106
A G D LL R A + A +GLT LH A DN + L+E GA+ + G
Sbjct: 570 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 629
Query: 107 WIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDI 166
+ PLH AA + IA L+ GA V +G TPL +A +E +++ +++ G +I
Sbjct: 630 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDK-GANI 688
Query: 167 EAARK----------EEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLK 216
+ K +E+++ + D L + H K G T L VA G +++
Sbjct: 689 HMSTKSGLTSLHLAAQEDKVNVADI---LTKHGADQDAHTKLGYTPLIVACHYGNVKMVN 745
Query: 217 LLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVADEDI 276
L++ G +VN K +G+TPLH AA G +L+ + G TA +A
Sbjct: 746 FLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKR-- 803
Query: 277 LGYL 280
LGY+
Sbjct: 804 LGYI 807
Score = 92.8 bits (229), Expect = 1e-18
Identities = 70/226 (30%), Positives = 100/226 (44%), Gaps = 27/226 (11%)
Query: 47 ACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEG 106
A G + VL LL GA + N+ G TALH A V++V+ L+ NGA ++ E
Sbjct: 438 AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREE 497
Query: 107 WIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDI 166
PLH A+ G +I + L+ AH A + G TPL I+ E VD+
Sbjct: 498 QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQ------------VDV 545
Query: 167 EAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVN 226
A L +G + + K G T LHVAA G +V KLL+Q +
Sbjct: 546 --------------ASVLLEAGAAHSLA-TKKGFTPLHVAAKYGSLDVAKLLLQRRAAAD 590
Query: 227 IKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVA 272
+G TPLH AAH+ ++ +L++ K G T +A
Sbjct: 591 SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIA 636
Score = 80.9 bits (198), Expect = 6e-15
Identities = 66/222 (29%), Positives = 96/222 (43%), Gaps = 27/222 (12%)
Query: 51 GDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPL 110
G D LL GA + A G T LH A ++D+ K L++ A + G PL
Sbjct: 541 GQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPL 600
Query: 111 HAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAAR 170
H AA +A L+ +GA A G TPL I AA+
Sbjct: 601 HVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHI----------------------AAK 638
Query: 171 KEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDY 230
K + +I A LN G ++ K G T LH+A+ +G+T+++ LL+ G ++++
Sbjct: 639 KNQMQI----ASTLLNYGAETNI-VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTK 693
Query: 231 DGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVA 272
G T LH AA K IL + D + K+G T VA
Sbjct: 694 SGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVA 735
Score = 76.6 bits (187), Expect = 1e-13
Identities = 58/218 (26%), Positives = 94/218 (43%), Gaps = 16/218 (7%)
Query: 66 INYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFL 125
+N G T LH A NV++ L+ GA ++ G PLH A+ G ++ + L
Sbjct: 226 VNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLL 285
Query: 126 IGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWL 185
+ +G + A +G TPL A +++++ + R G + A K L
Sbjct: 286 LDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLER-GAPLLARTKNG----LSPLHMAA 340
Query: 186 NSGHINDVRHAKSGG-----------TALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWT 234
H+ V+H TALHVAA G+ V KLL+ + N + +G+T
Sbjct: 341 QGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFT 400
Query: 235 PLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVA 272
PLH A + + +LV ++ + + G T VA
Sbjct: 401 PLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVA 438
Score = 47.4 bits (111), Expect = 7e-05
Identities = 131/612 (21%), Positives = 225/612 (36%), Gaps = 98/612 (16%)
Query: 324 IIEPEKNASRIESLEQEKVDEEEEGKKDESSCSSEEDEEDDSESE--AETDKTKPLASVT 381
++E S ES + E + E E + S S ++ EE E++ +T+ T + S
Sbjct: 2218 LMEGTPQISSEESYKHEGLAETPETSPESLSFSPKKSEEQTGETKESTKTETTTEIRSEK 2277
Query: 382 NANTSSTQAAPVAVTTPTVSSGQATPTSPIKKFPTTATKISPKEE--ERKDESPATWRLG 439
T+ TV+ T T +K AT SPK+ +R+D+ + +
Sbjct: 2278 EHPTTKDITGGSEERGATVTEDSETSTESFQK---EATLGSPKDTSPKRQDDCTGSCSVA 2334
Query: 440 LRKTGSYGALAEITASKEGQKEKDTAGVTRSASSPRLSSSLDNKEKEKDSKGTRLAYVAP 499
L K G L E A EGQ+ T +S+ + + + +E S T+ A
Sbjct: 2335 LAKETPTG-LTEEAACDEGQR-------TFGSSAHKTQTDSEVQESTATSDETK----AL 2382
Query: 500 TIPRRLASTSDIEEKE----------------NRDSSSLRTSSSYTRRKWEDDLKKNSSV 543
+P T E + +RDS L + + D + S V
Sbjct: 2383 PLPEASVKTDTGTESKPQGVIRSPQGLELALPSRDSEVLSAVADDSLAVSHKDSLEASPV 2442
Query: 544 NEGSTYHK---SCSFGRRQDDLISSSVPSTTSTPTVTSAAGLQKSLLSSTSTTTKITTGS 600
E ++ HK S ++ S+ S+ P + + L + T++ T
Sbjct: 2443 LEDNSSHKTPDSLEPSPLKESPCRDSLESSPVEPKMKAGIFPSHFPLPAAVAKTELLTEV 2502
Query: 601 SSAGTQSSTSNRLWAEDSTEKEKDSVPTAVTIPVAPTVVNAAASTTTLTTTTAGTVSSTT 660
+S ++ AED + ++ + ++ P++P ++ + +T TT
Sbjct: 2503 ASVRSRLLRDPDGSAEDDSLEQTSLMESSGKSPLSPDTPSSEEVSYEVTP-------KTT 2555
Query: 661 EVRERRRSYLTPVRDEE-SESQRKARSRQARQSRRSTQGVTLTDLQEAEKTIGRSRSTRT 719
+V + + + +E+ SE+ K R T +E K + T
Sbjct: 2556 DVSTPKPAVIHECAEEDDSENGEKKR---------------FTPEEEMFKMV-------T 2593
Query: 720 REQENEEKEKEEKEKQDKEKQEEKKESETSREDEYKQKYSRTYDETYQRYRPVSTSSSTT 779
+ + +E E+E K+K+D +K+ +++ES +S + + S DE P T S
Sbjct: 2594 KIKMFDELEQEAKQKRDYKKEPKQEESSSSSDPD--ADCSVDVDE------PKHTGSGED 2645
Query: 780 PSS--SLSTMSSSLYASSQLNRPNSLVGITSAYSRGITKENEREGEKREEEKEGEDKSQP 837
S L T S +SS + P L + G+ E + P
Sbjct: 2646 ESGVPVLVTSESRKVSSSSESEP-ELAQLKKGADSGLLPE--------PVIRVQPPSPLP 2696
Query: 838 KSIRERRRPREKRRSTGVSFWTQDSDENEQEQQSDTEEGSNKKETQTDSISRY----ETS 893
S+ P E V F S + + DT+E K E + DS S
Sbjct: 2697 SSMDSNSSPEE------VQFQPVVSKQYTFKMNEDTQEEPGKSEEEKDSESHLAEDRHAV 2750
Query: 894 STSAGDR-YDSL 904
ST A DR YD L
Sbjct: 2751 STEAEDRSYDKL 2762
Score = 45.8 bits (107), Expect = 2e-04
Identities = 25/81 (30%), Positives = 40/81 (49%)
Query: 45 LAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDN 104
+ AC G+ V LL +GA++N +G T LHQA + ++ L+++GA N
Sbjct: 733 IVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTA 792
Query: 105 EGWIPLHAAASCGYLDIAEFL 125
G L A GY+ + + L
Sbjct: 793 NGNTALAIAKRLGYISVVDTL 813
Score = 42.7 bits (99), Expect = 0.002
Identities = 112/536 (20%), Positives = 198/536 (36%), Gaps = 91/536 (16%)
Query: 220 QAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVADEDI--L 277
+ Y+V K D TP A H EE D E K T + + + +
Sbjct: 2545 EVSYEVTPKTTDVSTPKPAVIHECAEED---------DSENGEKKRFTPEEEMFKMVTKI 2595
Query: 278 GYLEELQKKQNLLHSEKRDKKSPLIESTANMDNNQSQKTFKNKETLIIEPEKNASRIESL 337
+EL+++ K++ K S+++ D + S + K T E E + +
Sbjct: 2596 KMFDELEQEAKQKRDYKKEPKQEESSSSSDPDADCSVDVDEPKHTGSGEDESGVPVLVTS 2655
Query: 338 EQEKVDEEEEGKKDESSCSSEEDEEDDSESEAETDKTKPLASVTNANTS--STQAAPVAV 395
E KV E + + + D E PL S ++N+S Q PV
Sbjct: 2656 ESRKVSSSSESEPELAQLKKGADSGLLPEPVIRVQPPSPLPSSMDSNSSPEEVQFQPVVS 2715
Query: 396 TTPTVSSGQATPTSPIKKFPTTATK---------ISPKEEERK----------------- 429
T + T P K ++ +S + E+R
Sbjct: 2716 KQYTFKMNEDTQEEPGKSEEEKDSESHLAEDRHAVSTEAEDRSYDKLNRDTDQPKICDGH 2775
Query: 430 -------DESPATWRLGLRK-TG----SYGALAEITASKEGQKEKDTAG----VTRS--- 470
S A GL+ TG + + + + +G EKDT G V+R+
Sbjct: 2776 GCEAMSPSSSAAPVSSGLQSPTGDDVDEQPVIYKESLALQGTHEKDTEGEELDVSRAESP 2835
Query: 471 ---------ASSPRLSSSLDNKEKEKDSKGTRLAYVAPTIPRRLASTSDIEEKE--NRDS 519
+SS L L ++ KE D + + + T + T + K+ ++DS
Sbjct: 2836 QADCPSESFSSSSSLPHCLVSEGKELDEDISATSSIQKTEVTKTDETFENLPKDCPSQDS 2895
Query: 520 SSLRTSSSYTRRKWEDDLKKNSSVNE---GSTYHK--SCSFGRRQDDLISSSVPSTTS-- 572
S + ++ DL +N + + S Y S SF ++ + TTS
Sbjct: 2896 SITTQTDRFSMDVPVSDLAENDEIYDPQITSPYENVPSQSFFSSEESKTQTDANHTTSFH 2955
Query: 573 ---TPTVTSAAGLQKSLLSSTSTTTKITTGSSSAG----TQSSTSNRLWAEDSTEKEKDS 625
+VT + ++ +++S+S+ T ++ S+ G +S + LW E + DS
Sbjct: 2956 SSEVYSVTITSPVEDVVVASSSSGTVLSKESNFEGQDIKMESQQESTLW-----EMQSDS 3010
Query: 626 VPTAV--TIPVAPTVVNAAASTTTLTTTTAGTVSSTTEVRERRRSYLTPVRDEESE 679
V ++ T+ TVV S +T T + S +E+RE ++ V++EE +
Sbjct: 3011 VSSSFEPTMSATTTVVGEQISKVIITKTDVDS-DSWSEIREDDEAFEARVKEEEQK 3065
Score = 40.8 bits (94), Expect = 0.007
Identities = 136/712 (19%), Positives = 254/712 (35%), Gaps = 99/712 (13%)
Query: 290 LHSEKRDKKSPLIESTANMDNNQSQK--TFKNKETLIIEPEKNASRIESLEQEKVDEEEE 347
L SE + K LI+ TA + + S K + K KE + E+ E +E+ K D E+
Sbjct: 1503 LLSEVSEMKQDLIKMTAILTTDVSDKAGSIKVKELVKAAEEEPGEPFEIVERVKEDLEKV 1562
Query: 348 GKKDES-SCSSEEDEEDDSESEAETDKTKPLASVTNANTSSTQAAPVAVTTPTVSSGQAT 406
+ S +C+ +E S SE + + + + Q AP+ +T
Sbjct: 1563 NEILRSGTCTRDESSVQSSRSERGLVEEEWVIVSDEEIEEARQKAPLEIT---------- 1612
Query: 407 PTSPIKKFPTTATKISPKEEERKDESPATWRLGLRKTGSYGALAEITASKEG-QKEKDTA 465
++P +I KE + K E +T GL + + KE Q +D A
Sbjct: 1613 ------EYPCVEVRID-KEIKGKVEKDST---GLVNYLTDDLNTCVPLPKEQLQTVQDKA 1662
Query: 466 GVTRSASSPRLSSSLDNKEKEKDSKGTRLAYVAPTIPRRLASTSDIEEKENRDSSSLRTS 525
G A + SS + K+ D + P++ + ++EK+ + L+ S
Sbjct: 1663 GKKCEALAVGRSSEKEGKDIPPDETQSTQKQHKPSLGIKKPVRRKLKEKQKQKEEGLQAS 1722
Query: 526 SSYTRRKWEDDLKKNSSVNEGSTYHKSCSFGRRQDDLISSSVPSTTSTPTVT---SAAGL 582
+ + +LKK SS + + + ++ P TP + L
Sbjct: 1723 AE------KAELKKGSSEE---SLGEDPGLAPEPLPTVKATSPLIEETPIGSIKDKVKAL 1773
Query: 583 QKSLLSSTSTTTKI---TTGSSSAGTQSSTSNRLWAEDSTEKEKDSVPTAVTIPVAPTVV 639
QK + +K+ G +++ A S + E+ + P +P+
Sbjct: 1774 QKRVEDEQKGRSKLPIRVKGKEDVPKKTTHRPHPAASPSLKSERHA-------PGSPSPK 1826
Query: 640 NAAASTTTLTTTTAGTVSSTTEVRERRRSYLTPVRDEESESQRKARSRQARQS------- 692
ST + + T + + + S ++P E S + S+ + S
Sbjct: 1827 TERHSTLSSSAKTERHPPVSPSSKTEKHSPVSPSAKTERHSPASSSSKTEKHSPVSPSTK 1886
Query: 693 --RRSTQGVTLTDLQEAEKTIGRSRSTRTREQENEEKEKEEKEKQDKEKQEEKKESETSR 750
R S T T E + S T R + E+ + E++ S
Sbjct: 1887 TERHSPVSSTKT---ERHPPVSPSGKTDKRPPVSPSGRTEKHPPVSPGRTEKRLPVSPSG 1943
Query: 751 EDEYKQKYSRTYDETYQRYRPVSTSSSTTPSSSLSTMSSSLYASSQLNRPNSLVGITSAY 810
+ Q S T +T +++ PVS S T +S S + ++ S+ + A+
Sbjct: 1944 RTDKHQPVS-TAGKT-EKHLPVSPSGKTEKQPPVSPTSKT----ERIEETMSVRELMKAF 1997
Query: 811 SRGITKENEREG---EKREEEKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQ 867
G + G K ++K+ ++K + + +E+ +R + T++
Sbjct: 1998 QSGQDPSKHKTGLFEHKSAKQKQPQEKGKVRVEKEKGPILTQREAQK----TENQTIKRG 2053
Query: 868 EQQSDTEEGSNKKETQTDSISRYETSSTSAGDRYDSLLGRSGSYSYLEERKPYSSRLEKD 927
++ T +K+ + SI + + ++ S S EE S + K+
Sbjct: 2054 QRLPVTGTAESKRGVRVSSIGVKKEDAAGGKEKVLSHKIPEPVQSVPEEESHRESEVPKE 2113
Query: 928 D------------------STDFKKLYEQILAENEKL----------KAQLH 951
STDF ++ +Q L +N+K KAQLH
Sbjct: 2114 KMADEQGDMDLQISPDRKTSTDFSEVIKQELEDNDKYQQFRLSEETEKAQLH 2165
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 109 bits (272), Expect = 2e-23
Identities = 79/246 (32%), Positives = 121/246 (49%), Gaps = 31/246 (12%)
Query: 59 LLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGY 118
LLH GAD++ + GL LH AC + ++ + LV +GA++N D + PLH AA+ G
Sbjct: 703 LLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGK 762
Query: 119 LDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARK------- 171
+I + L+ GA N +G+TPLD+ +E + +Q+ + ++AA+K
Sbjct: 763 YEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTD--IQDLLRGDAALLDAAKKGCLARVQ 820
Query: 172 ---EEERIMLRDAR------QWLNSGHIN------------DVRHAKSGG-TALHVAAAK 209
E I RD + L +G+ N DV GG LH AA+
Sbjct: 821 KLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASY 880
Query: 210 GYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAF 269
G+ ++ LLI+ VN D +TPLH AA G+ + C +L+ + D M N+ GQT
Sbjct: 881 GHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPL 940
Query: 270 DVADED 275
D+A D
Sbjct: 941 DLATAD 946
Score = 102 bits (255), Expect = 1e-21
Identities = 85/256 (33%), Positives = 127/256 (49%), Gaps = 33/256 (12%)
Query: 47 ACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEG 106
A G D V LL GA+++ + GL LH AC + ++V L+ GA+ N DN
Sbjct: 223 AAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWN 282
Query: 107 WIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDI 166
+ PLH AA G +D+ L+ GA N++G + LD+A+ A + +L E + + +
Sbjct: 283 YTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSA-KAVLTGEYKKDEL-L 340
Query: 167 EAARK-EEERIML-----------RDARQ----WLNSGHINDVR------------HAKS 198
EAAR EE++M D R+ L +G+ N VR HAK
Sbjct: 341 EAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGY-NRVRIVQLLLQHGADVHAKD 399
Query: 199 GG--TALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLC 256
G LH A + G+ EV +LL++ G VN D +TPLH AA + E C +L+ +
Sbjct: 400 KGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGA 459
Query: 257 DMEMVNKVGQTAFDVA 272
D +VN G++A D+A
Sbjct: 460 DPTLVNCHGKSAVDMA 475
Score = 94.7 bits (234), Expect = 4e-19
Identities = 74/271 (27%), Positives = 123/271 (45%), Gaps = 35/271 (12%)
Query: 59 LLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGY 118
LL +GA++N N D +T LH A + D+++ L ++GA +N D G LH AA G+
Sbjct: 544 LLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGH 603
Query: 119 LDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERI-M 177
L L+ G+ ++ +G T + EA++++L + D++ E +
Sbjct: 604 LQTCRLLLSYGSDPSIISLQGFTAAQMG-NEAVQQILSESTPIRTSDVDYRLLEASKAGD 662
Query: 178 LRDARQWLNSGHIN----DVRHA-----------------------------KSGGTALH 204
L +Q +S ++N + RH+ K G LH
Sbjct: 663 LETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLH 722
Query: 205 VAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKV 264
A + G+ EV +LL++ G VN+ D +TPLH AA GK E C++L+ + D N+
Sbjct: 723 NACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRD 782
Query: 265 GQTAFDVADEDILGYLEELQKKQNLLHSEKR 295
G T D+ E + L+ LL + K+
Sbjct: 783 GNTPLDLVKEGDTDIQDLLRGDAALLDAAKK 813
Score = 94.4 bits (233), Expect = 5e-19
Identities = 67/213 (31%), Positives = 109/213 (51%), Gaps = 9/213 (4%)
Query: 59 LLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGY 118
LL GAD++ + GL LH AC + ++ + L+++GA +N D + PLH AAS
Sbjct: 388 LLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNR 447
Query: 119 LDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERIML 178
+++ L+ GA VN G + +D+A + E L E + ++AAR+ + L
Sbjct: 448 VEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSL-LQAAREAD----L 502
Query: 179 RDARQWLNSGHINDVRHAKSGGTALHVAAAKGY---TEVLKLLIQAGYDVNIKDYDGWTP 235
++ L IN + +S TALH A A + +V +LL++ G +VN K+ D TP
Sbjct: 503 AKVKKTLALEIIN-FKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTP 561
Query: 236 LHAAAHWGKEEACRILVDNLCDMEMVNKVGQTA 268
LH AA + +L + M ++ +GQTA
Sbjct: 562 LHVAAERAHNDVMEVLHKHGAKMNALDTLGQTA 594
Score = 64.7 bits (156), Expect = 4e-10
Identities = 35/97 (36%), Positives = 48/97 (49%)
Query: 59 LLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGY 118
LL GAD+N + GL LH A +VD+ L++ +N D + PLH AA G
Sbjct: 856 LLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGR 915
Query: 119 LDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELL 155
+ L+ GA N EG TPLD+A + + LL
Sbjct: 916 TQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALL 952
Score = 63.2 bits (152), Expect = 1e-09
Identities = 44/145 (30%), Positives = 67/145 (46%), Gaps = 2/145 (1%)
Query: 195 HAKSGG--TALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILV 252
HA+ G LH A + G+ EV+ LL+ G D N +D +TPLH AA GK + C +L+
Sbjct: 243 HARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLL 302
Query: 253 DNLCDMEMVNKVGQTAFDVADEDILGYLEELQKKQNLLHSEKRDKKSPLIESTANMDNNQ 312
+ D + N G++A D+AD L KK LL + + + L+ ++ N
Sbjct: 303 QHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNC 362
Query: 313 SQKTFKNKETLIIEPEKNASRIESL 337
+ L + N RI L
Sbjct: 363 HASDGRKSTPLHLAAGYNRVRIVQL 387
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 [Homo
sapiens]
Length = 2542
Score = 108 bits (271), Expect = 2e-23
Identities = 140/549 (25%), Positives = 235/549 (42%), Gaps = 53/549 (9%)
Query: 47 ACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNE- 105
ACS G + V LL RGA+ + NV T L A V+++K L+ GA IN
Sbjct: 1129 ACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSK 1188
Query: 106 -GWIPLHAAASCGYLDIAEFLIGQGAHVGA-VNSEGDTPLDIAEEEAMEELLQNEVNRQG 163
G PL AA G++ + L+ G+ + A + + +T L +A + E++ ++R+
Sbjct: 1189 LGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRK- 1247
Query: 164 VDIEAARKEEERIMLRDA--------RQWLNSG-HINDVRHAKSGGTALHVAAAKGYTEV 214
++E K ++ A R L+ G +N S TAL +AA KG+ +
Sbjct: 1248 ANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKF 1307
Query: 215 LKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQT----AFD 270
+LLI G +++++ G TPL A++ G + ++LV D++ + T AF
Sbjct: 1308 CELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFR 1367
Query: 271 VADEDILGYL-----------EELQKKQNLLHSEKRDKKSPLIESTANMDNNQSQKTFKN 319
++ YL E ++ + E K +E+ + Q+ + KN
Sbjct: 1368 KGHVKVVQYLVKEVNQFPSDIECMRYIATITDKELLKKCHQCVETIVKAKDQQAAEANKN 1427
Query: 320 KETLIIEPEKNASRIESLEQ------EKVDEEEEGKKDESSCSSEEDEEDDSESEAETDK 373
L+ E + SR ES +Q EK E+ + KK+E EEDEE+ + +E +
Sbjct: 1428 ASILLKELDLEKSREESRKQALAAKREKRKEKRKKKKEEQKRKQEEDEENKPKENSELPE 1487
Query: 374 TKPLASVTNANTSSTQAAPVAVTTPT---VSSGQATPTSPI-KKFPTTATKISPKEEERK 429
+ P + TT T +S+ AT T+ KK T S + +K
Sbjct: 1488 DEDEEENDEDVEQEVPIEPPSATTTTTIGISATSATFTNVFGKKRANVVTTPSTNRKNKK 1547
Query: 430 D---ESPATWRLGLRKTGSYGALAEITASKEG-QKEKDTAGVTRSASSPRLSSSLDNKEK 485
+ E+P T L L + + +LA+ A K E G ++ S L S+ N E
Sbjct: 1548 NKTKETPPTAHLILPE--QHMSLAQQKADKNKINGEPRGGGAGGNSDSDNLDSTDCNSES 1605
Query: 486 EKDSKGTRLAYVAPTIPRRLASTSDIEEKENRDSSSLRTSSSYTRRKWEDDLKKNSSVNE 545
K L +V + S + +E + S T++S T+ + E ++ NS
Sbjct: 1606 SSGGKSQELNFVMDVNSSKYPSLL-LHSQEEKTS----TATSKTQTRLEGEVTPNSL--- 1657
Query: 546 GSTYHKSCS 554
ST +K+ S
Sbjct: 1658 -STSYKTVS 1665
Score = 99.0 bits (245), Expect = 2e-20
Identities = 84/272 (30%), Positives = 132/272 (48%), Gaps = 37/272 (13%)
Query: 37 KFDDGAVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENG 96
+F + A+ LA C G D V LL GAD + + TAL +AC+D +V++ + L+++G
Sbjct: 370 EFKESALTLA-CYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG 428
Query: 97 ANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQ 156
A +N P + PL AA G++++A LI +GA++ VN EG TPL A E EE++
Sbjct: 429 AQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVA 488
Query: 157 NEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLK 216
+ QG +I A +E + TAL +A G++EV
Sbjct: 489 -LLLAQGANINAQTEETQE-------------------------TALTLACCGGFSEVAD 522
Query: 217 LLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVADE-- 274
LI+AG D+ + TPL A+ G E + L+ + ++ G TA A E
Sbjct: 523 FLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENG 579
Query: 275 --DILGYLEELQKKQNLLHSEKRDKKSPLIES 304
D+ L LQ +L H E ++PL+++
Sbjct: 580 HTDVADVL--LQAGADLEH-ESEGGRTPLMKA 608
Score = 86.7 bits (213), Expect = 1e-16
Identities = 69/223 (30%), Positives = 99/223 (44%), Gaps = 26/223 (11%)
Query: 45 LAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDN 104
+AA S G D V LL AD+N + G TAL AC VD+VK L+ GANI +
Sbjct: 277 MAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNE 336
Query: 105 EGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGV 164
G PL AAS G++++A L+ GA + ++E E + ++
Sbjct: 337 NGHTPLMEAASAGHVEVARVLLDHGAGINTHSNE------FKESALTLACYKGHLDMVRF 390
Query: 165 DIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYD 224
+EA +E H D H TAL A G+ EV +LL+ +G
Sbjct: 391 LLEAGADQE---------------HKTDEMH-----TALMEACMDGHVEVARLLLDSGAQ 430
Query: 225 VNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQT 267
VN+ +PL AA G E +L++ ++E VN G T
Sbjct: 431 VNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYT 473
Score = 72.0 bits (175), Expect = 3e-12
Identities = 61/231 (26%), Positives = 108/231 (46%), Gaps = 39/231 (16%)
Query: 25 EPPVVKRQKTKVKFDDGAVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDD 84
+P V++R + V +C+ + L + N VD +L +AC D
Sbjct: 168 DPEVLRRLTSSV----------SCALDEAAAALTRMKAENSHNAGQVD-TRSLAEACSDG 216
Query: 85 NVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGD-TPL 143
+V+ V+ L++ G ++N+ EG L A S GY ++A+ L+ A+V ++GD TPL
Sbjct: 217 DVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPL 276
Query: 144 DIAEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTAL 203
A +++ + ++L DA +NS + +G TAL
Sbjct: 277 MAASSGGYLDIV------------------KLLLLHDAD--VNS-------QSATGNTAL 309
Query: 204 HVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDN 254
A A G+ +++K+L+ G ++ + +G TPL AA G E R+L+D+
Sbjct: 310 TYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH 360
Score = 72.0 bits (175), Expect = 3e-12
Identities = 59/203 (29%), Positives = 97/203 (47%), Gaps = 10/203 (4%)
Query: 75 TALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGA 134
TAL AC + ++V L+ A I D +G+ PL AA+ G++ + E L+ +G + A
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116
Query: 135 VNSE-GDTPLDIA----EEEAMEELL---QNEVNRQGVDIEAARKEEERIMLRDARQWLN 186
+ DTPL +A +E ++ LL N+ +R D + + LN
Sbjct: 1117 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1176
Query: 187 SG-HINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIK-DYDGWTPLHAAAHWGK 244
+G IN +K G + L +AA G+ +KLL+ G D+N + + + T L A G+
Sbjct: 1177 AGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGR 1236
Query: 245 EEACRILVDNLCDMEMVNKVGQT 267
E +L+D ++E K G T
Sbjct: 1237 AEVVSLLLDRKANVEHRAKTGLT 1259
Score = 54.7 bits (130), Expect = 4e-07
Identities = 31/96 (32%), Positives = 48/96 (50%)
Query: 45 LAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDN 104
+ A G + V LL GA+++ G TAL AC + + D+ L++ GA++
Sbjct: 540 MEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESE 599
Query: 105 EGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGD 140
G PL AA G+L +FLI +GA+V + D
Sbjct: 600 GGRTPLMKAARAGHLCTVQFLISKGANVNRATANND 635
Score = 44.3 bits (103), Expect = 6e-04
Identities = 31/144 (21%), Positives = 75/144 (52%), Gaps = 16/144 (11%)
Query: 669 YLTPVRDEES--------ESQRKARSRQARQSRRSTQGVTLTDLQEAEKTIGRSRST--- 717
Y+ + D+E E+ KA+ +QA ++ ++ + L +L + EK+ SR
Sbjct: 1393 YIATITDKELLKKCHQCVETIVKAKDQQAAEANKNAS-ILLKEL-DLEKSREESRKQALA 1450
Query: 718 ---RTREQENEEKEKEEKEKQDKEKQEEKKESETSREDEYKQKYSRTYDETYQRYRPVST 774
R+++ ++K++E+K KQ+++++ + KE+ EDE +++ ++ P +T
Sbjct: 1451 AKREKRKEKRKKKKEEQKRKQEEDEENKPKENSELPEDEDEEENDEDVEQEVPIEPPSAT 1510
Query: 775 SSSTTPSSSLSTMSSSLYASSQLN 798
+++T S+ S ++++ + N
Sbjct: 1511 TTTTIGISATSATFTNVFGKKRAN 1534
Score = 41.2 bits (95), Expect = 0.005
Identities = 62/276 (22%), Positives = 108/276 (39%), Gaps = 58/276 (21%)
Query: 13 QLKRWIGSETDLEPPVVKRQKTKVKFDDGAVFLAACSSG--------DTDEVLKLLHRGA 64
+++ +I + DL+ PV+K +FL++ + G +T L+ L A
Sbjct: 102 EVESFILDQEDLDNPVLKTTSE--------IFLSSTAEGADLRTVDPETQARLEALLEAA 153
Query: 65 DIN-YANVDG-----------LTALHQACIDDNVD-MVKFLVENGANINQPDNEGWIPLH 111
I + DG LT+ +D+ + + EN N Q D L
Sbjct: 154 GIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRS---LA 210
Query: 112 AAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARK 171
A S G ++ L+ +G V EG++ L +A EL Q
Sbjct: 211 EACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQ--------------- 255
Query: 172 EEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYD 231
++L + G+ D+ T L A++ GY +++KLL+ DVN +
Sbjct: 256 ----VLLAMHANVEDRGNKGDI-------TPLMAASSGGYLDIVKLLLLHDADVNSQSAT 304
Query: 232 GWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQT 267
G T L A G + ++L++ ++E N+ G T
Sbjct: 305 GNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHT 340
Score = 36.6 bits (83), Expect = 0.13
Identities = 23/68 (33%), Positives = 34/68 (50%)
Query: 192 DVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRIL 251
D + TAL +A A G+ E++ +LI + +D G+TPL AA G IL
Sbjct: 1048 DAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEIL 1107
Query: 252 VDNLCDME 259
+D D+E
Sbjct: 1108 LDKGGDIE 1115
Score = 34.3 bits (77), Expect = 0.62
Identities = 46/183 (25%), Positives = 76/183 (41%), Gaps = 8/183 (4%)
Query: 96 GANINQPDNEGWIPLHA---AASCGYLDIAEFLIGQGAHV-GAVNSEGDTPLDIAEEEAM 151
GA++ D E L A AA G L A+ V + S LD A
Sbjct: 132 GADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALT 191
Query: 152 EELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGH-INDVRHAKSGGTALHVAAAKG 210
+N N VD + + + R+ L+ G +N+ H + G + L +A + G
Sbjct: 192 RMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNE--HTEEGESLLCLACSAG 249
Query: 211 YTEVLKLLIQAGYDVNIKDYDG-WTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAF 269
Y E+ ++L+ +V + G TPL AA+ G + ++L+ + D+ + G TA
Sbjct: 250 YYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTAL 309
Query: 270 DVA 272
A
Sbjct: 310 TYA 312
Score = 32.3 bits (72), Expect = 2.4
Identities = 21/83 (25%), Positives = 42/83 (50%), Gaps = 1/83 (1%)
Query: 45 LAACSSGDTDEVLKLLHRGADINYANVDG-LTALHQACIDDNVDMVKFLVENGANINQPD 103
+ A +G V L+ +GA++N A + T + AC ++ +V+ L+ +GA+
Sbjct: 606 MKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRL 665
Query: 104 NEGWIPLHAAASCGYLDIAEFLI 126
+G L AA G+ ++ +L+
Sbjct: 666 KDGSTMLIEAAKGGHTNVVSYLL 688
Score = 31.6 bits (70), Expect = 4.0
Identities = 16/81 (19%), Positives = 38/81 (46%)
Query: 348 GKKDESSCSSEEDEEDDSESEAETDKTKPLASVTNANTSSTQAAPVAVTTPTVSSGQATP 407
G + SS +++ EA+ L+ ++ S+++ AP+ +T+P + +
Sbjct: 2060 GAPETHPSSSPTPTSSNTQEEAQPSSVSDLSPMSMPFASNSEPAPLTLTSPRMVAADNQD 2119
Query: 408 TSPIKKFPTTATKISPKEEER 428
TS + + A ++S + + R
Sbjct: 2120 TSNLPQLAVPAPRVSHRMQPR 2140
Score = 31.2 bits (69), Expect = 5.3
Identities = 19/61 (31%), Positives = 30/61 (49%)
Query: 39 DDGAVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGAN 98
+D V AC+ G V LL GAD + DG T L +A + ++V +L++ N
Sbjct: 634 NDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNN 693
Query: 99 I 99
+
Sbjct: 694 V 694
Score = 30.4 bits (67), Expect = 9.0
Identities = 20/86 (23%), Positives = 39/86 (45%), Gaps = 10/86 (11%)
Query: 812 RGITKENEREGEKREEEKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQEQQS 871
+ + + E+ EKR+++KE + + Q + E +P+E DE+E+E
Sbjct: 1447 QALAAKREKRKEKRKKKKEEQKRKQEED--EENKPKENSELP--------EDEDEEENDE 1496
Query: 872 DTEEGSNKKETQTDSISRYETSSTSA 897
D E+ + + + S+TSA
Sbjct: 1497 DVEQEVPIEPPSATTTTTIGISATSA 1522
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 108 bits (271), Expect = 2e-23
Identities = 140/549 (25%), Positives = 235/549 (42%), Gaps = 53/549 (9%)
Query: 47 ACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNE- 105
ACS G + V LL RGA+ + NV T L A V+++K L+ GA IN
Sbjct: 1129 ACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSK 1188
Query: 106 -GWIPLHAAASCGYLDIAEFLIGQGAHVGA-VNSEGDTPLDIAEEEAMEELLQNEVNRQG 163
G PL AA G++ + L+ G+ + A + + +T L +A + E++ ++R+
Sbjct: 1189 LGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRK- 1247
Query: 164 VDIEAARKEEERIMLRDA--------RQWLNSG-HINDVRHAKSGGTALHVAAAKGYTEV 214
++E K ++ A R L+ G +N S TAL +AA KG+ +
Sbjct: 1248 ANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKF 1307
Query: 215 LKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQT----AFD 270
+LLI G +++++ G TPL A++ G + ++LV D++ + T AF
Sbjct: 1308 CELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFR 1367
Query: 271 VADEDILGYL-----------EELQKKQNLLHSEKRDKKSPLIESTANMDNNQSQKTFKN 319
++ YL E ++ + E K +E+ + Q+ + KN
Sbjct: 1368 KGHVKVVQYLVKEVNQFPSDIECMRYIATITDKELLKKCHQCVETIVKAKDQQAAEANKN 1427
Query: 320 KETLIIEPEKNASRIESLEQ------EKVDEEEEGKKDESSCSSEEDEEDDSESEAETDK 373
L+ E + SR ES +Q EK E+ + KK+E EEDEE+ + +E +
Sbjct: 1428 ASILLKELDLEKSREESRKQALAAKREKRKEKRKKKKEEQKRKQEEDEENKPKENSELPE 1487
Query: 374 TKPLASVTNANTSSTQAAPVAVTTPT---VSSGQATPTSPI-KKFPTTATKISPKEEERK 429
+ P + TT T +S+ AT T+ KK T S + +K
Sbjct: 1488 DEDEEENDEDVEQEVPIEPPSATTTTTIGISATSATFTNVFGKKRANVVTTPSTNRKNKK 1547
Query: 430 D---ESPATWRLGLRKTGSYGALAEITASKEG-QKEKDTAGVTRSASSPRLSSSLDNKEK 485
+ E+P T L L + + +LA+ A K E G ++ S L S+ N E
Sbjct: 1548 NKTKETPPTAHLILPE--QHMSLAQQKADKNKINGEPRGGGAGGNSDSDNLDSTDCNSES 1605
Query: 486 EKDSKGTRLAYVAPTIPRRLASTSDIEEKENRDSSSLRTSSSYTRRKWEDDLKKNSSVNE 545
K L +V + S + +E + S T++S T+ + E ++ NS
Sbjct: 1606 SSGGKSQELNFVMDVNSSKYPSLL-LHSQEEKTS----TATSKTQTRLEGEVTPNSL--- 1657
Query: 546 GSTYHKSCS 554
ST +K+ S
Sbjct: 1658 -STSYKTVS 1665
Score = 99.0 bits (245), Expect = 2e-20
Identities = 84/272 (30%), Positives = 132/272 (48%), Gaps = 37/272 (13%)
Query: 37 KFDDGAVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENG 96
+F + A+ LA C G D V LL GAD + + TAL +AC+D +V++ + L+++G
Sbjct: 370 EFKESALTLA-CYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG 428
Query: 97 ANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQ 156
A +N P + PL AA G++++A LI +GA++ VN EG TPL A E EE++
Sbjct: 429 AQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVA 488
Query: 157 NEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLK 216
+ QG +I A +E + TAL +A G++EV
Sbjct: 489 -LLLAQGANINAQTEETQE-------------------------TALTLACCGGFSEVAD 522
Query: 217 LLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVADE-- 274
LI+AG D+ + TPL A+ G E + L+ + ++ G TA A E
Sbjct: 523 FLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENG 579
Query: 275 --DILGYLEELQKKQNLLHSEKRDKKSPLIES 304
D+ L LQ +L H E ++PL+++
Sbjct: 580 HTDVADVL--LQAGADLEH-ESEGGRTPLMKA 608
Score = 86.7 bits (213), Expect = 1e-16
Identities = 69/223 (30%), Positives = 99/223 (44%), Gaps = 26/223 (11%)
Query: 45 LAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDN 104
+AA S G D V LL AD+N + G TAL AC VD+VK L+ GANI +
Sbjct: 277 MAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNE 336
Query: 105 EGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGV 164
G PL AAS G++++A L+ GA + ++E E + ++
Sbjct: 337 NGHTPLMEAASAGHVEVARVLLDHGAGINTHSNE------FKESALTLACYKGHLDMVRF 390
Query: 165 DIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYD 224
+EA +E H D H TAL A G+ EV +LL+ +G
Sbjct: 391 LLEAGADQE---------------HKTDEMH-----TALMEACMDGHVEVARLLLDSGAQ 430
Query: 225 VNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQT 267
VN+ +PL AA G E +L++ ++E VN G T
Sbjct: 431 VNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYT 473
Score = 72.0 bits (175), Expect = 3e-12
Identities = 61/231 (26%), Positives = 108/231 (46%), Gaps = 39/231 (16%)
Query: 25 EPPVVKRQKTKVKFDDGAVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDD 84
+P V++R + V +C+ + L + N VD +L +AC D
Sbjct: 168 DPEVLRRLTSSV----------SCALDEAAAALTRMKAENSHNAGQVD-TRSLAEACSDG 216
Query: 85 NVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGD-TPL 143
+V+ V+ L++ G ++N+ EG L A S GY ++A+ L+ A+V ++GD TPL
Sbjct: 217 DVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPL 276
Query: 144 DIAEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTAL 203
A +++ + ++L DA +NS + +G TAL
Sbjct: 277 MAASSGGYLDIV------------------KLLLLHDAD--VNS-------QSATGNTAL 309
Query: 204 HVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDN 254
A A G+ +++K+L+ G ++ + +G TPL AA G E R+L+D+
Sbjct: 310 TYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH 360
Score = 72.0 bits (175), Expect = 3e-12
Identities = 59/203 (29%), Positives = 97/203 (47%), Gaps = 10/203 (4%)
Query: 75 TALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGA 134
TAL AC + ++V L+ A I D +G+ PL AA+ G++ + E L+ +G + A
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116
Query: 135 VNSE-GDTPLDIA----EEEAMEELL---QNEVNRQGVDIEAARKEEERIMLRDARQWLN 186
+ DTPL +A +E ++ LL N+ +R D + + LN
Sbjct: 1117 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1176
Query: 187 SG-HINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIK-DYDGWTPLHAAAHWGK 244
+G IN +K G + L +AA G+ +KLL+ G D+N + + + T L A G+
Sbjct: 1177 AGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGR 1236
Query: 245 EEACRILVDNLCDMEMVNKVGQT 267
E +L+D ++E K G T
Sbjct: 1237 AEVVSLLLDRKANVEHRAKTGLT 1259
Score = 54.7 bits (130), Expect = 4e-07
Identities = 31/96 (32%), Positives = 48/96 (50%)
Query: 45 LAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDN 104
+ A G + V LL GA+++ G TAL AC + + D+ L++ GA++
Sbjct: 540 MEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESE 599
Query: 105 EGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGD 140
G PL AA G+L +FLI +GA+V + D
Sbjct: 600 GGRTPLMKAARAGHLCTVQFLISKGANVNRATANND 635
Score = 44.3 bits (103), Expect = 6e-04
Identities = 31/144 (21%), Positives = 75/144 (52%), Gaps = 16/144 (11%)
Query: 669 YLTPVRDEES--------ESQRKARSRQARQSRRSTQGVTLTDLQEAEKTIGRSRST--- 717
Y+ + D+E E+ KA+ +QA ++ ++ + L +L + EK+ SR
Sbjct: 1393 YIATITDKELLKKCHQCVETIVKAKDQQAAEANKNAS-ILLKEL-DLEKSREESRKQALA 1450
Query: 718 ---RTREQENEEKEKEEKEKQDKEKQEEKKESETSREDEYKQKYSRTYDETYQRYRPVST 774
R+++ ++K++E+K KQ+++++ + KE+ EDE +++ ++ P +T
Sbjct: 1451 AKREKRKEKRKKKKEEQKRKQEEDEENKPKENSELPEDEDEEENDEDVEQEVPIEPPSAT 1510
Query: 775 SSSTTPSSSLSTMSSSLYASSQLN 798
+++T S+ S ++++ + N
Sbjct: 1511 TTTTIGISATSATFTNVFGKKRAN 1534
Score = 41.2 bits (95), Expect = 0.005
Identities = 62/276 (22%), Positives = 108/276 (39%), Gaps = 58/276 (21%)
Query: 13 QLKRWIGSETDLEPPVVKRQKTKVKFDDGAVFLAACSSG--------DTDEVLKLLHRGA 64
+++ +I + DL+ PV+K +FL++ + G +T L+ L A
Sbjct: 102 EVESFILDQEDLDNPVLKTTSE--------IFLSSTAEGADLRTVDPETQARLEALLEAA 153
Query: 65 DIN-YANVDG-----------LTALHQACIDDNVD-MVKFLVENGANINQPDNEGWIPLH 111
I + DG LT+ +D+ + + EN N Q D L
Sbjct: 154 GIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRS---LA 210
Query: 112 AAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARK 171
A S G ++ L+ +G V EG++ L +A EL Q
Sbjct: 211 EACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQ--------------- 255
Query: 172 EEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYD 231
++L + G+ D+ T L A++ GY +++KLL+ DVN +
Sbjct: 256 ----VLLAMHANVEDRGNKGDI-------TPLMAASSGGYLDIVKLLLLHDADVNSQSAT 304
Query: 232 GWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQT 267
G T L A G + ++L++ ++E N+ G T
Sbjct: 305 GNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHT 340
Score = 36.6 bits (83), Expect = 0.13
Identities = 23/68 (33%), Positives = 34/68 (50%)
Query: 192 DVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRIL 251
D + TAL +A A G+ E++ +LI + +D G+TPL AA G IL
Sbjct: 1048 DAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEIL 1107
Query: 252 VDNLCDME 259
+D D+E
Sbjct: 1108 LDKGGDIE 1115
Score = 34.3 bits (77), Expect = 0.62
Identities = 46/183 (25%), Positives = 76/183 (41%), Gaps = 8/183 (4%)
Query: 96 GANINQPDNEGWIPLHA---AASCGYLDIAEFLIGQGAHV-GAVNSEGDTPLDIAEEEAM 151
GA++ D E L A AA G L A+ V + S LD A
Sbjct: 132 GADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALT 191
Query: 152 EELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGH-INDVRHAKSGGTALHVAAAKG 210
+N N VD + + + R+ L+ G +N+ H + G + L +A + G
Sbjct: 192 RMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNE--HTEEGESLLCLACSAG 249
Query: 211 YTEVLKLLIQAGYDVNIKDYDG-WTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAF 269
Y E+ ++L+ +V + G TPL AA+ G + ++L+ + D+ + G TA
Sbjct: 250 YYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTAL 309
Query: 270 DVA 272
A
Sbjct: 310 TYA 312
Score = 32.3 bits (72), Expect = 2.4
Identities = 21/83 (25%), Positives = 42/83 (50%), Gaps = 1/83 (1%)
Query: 45 LAACSSGDTDEVLKLLHRGADINYANVDG-LTALHQACIDDNVDMVKFLVENGANINQPD 103
+ A +G V L+ +GA++N A + T + AC ++ +V+ L+ +GA+
Sbjct: 606 MKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRL 665
Query: 104 NEGWIPLHAAASCGYLDIAEFLI 126
+G L AA G+ ++ +L+
Sbjct: 666 KDGSTMLIEAAKGGHTNVVSYLL 688
Score = 31.6 bits (70), Expect = 4.0
Identities = 16/81 (19%), Positives = 38/81 (46%)
Query: 348 GKKDESSCSSEEDEEDDSESEAETDKTKPLASVTNANTSSTQAAPVAVTTPTVSSGQATP 407
G + SS +++ EA+ L+ ++ S+++ AP+ +T+P + +
Sbjct: 2060 GAPETHPSSSPTPTSSNTQEEAQPSSVSDLSPMSMPFASNSEPAPLTLTSPRMVAADNQD 2119
Query: 408 TSPIKKFPTTATKISPKEEER 428
TS + + A ++S + + R
Sbjct: 2120 TSNLPQLAVPAPRVSHRMQPR 2140
Score = 31.2 bits (69), Expect = 5.3
Identities = 19/61 (31%), Positives = 30/61 (49%)
Query: 39 DDGAVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGAN 98
+D V AC+ G V LL GAD + DG T L +A + ++V +L++ N
Sbjct: 634 NDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNN 693
Query: 99 I 99
+
Sbjct: 694 V 694
Score = 30.4 bits (67), Expect = 9.0
Identities = 20/86 (23%), Positives = 39/86 (45%), Gaps = 10/86 (11%)
Query: 812 RGITKENEREGEKREEEKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQEQQS 871
+ + + E+ EKR+++KE + + Q + E +P+E DE+E+E
Sbjct: 1447 QALAAKREKRKEKRKKKKEEQKRKQEED--EENKPKENSELP--------EDEDEEENDE 1496
Query: 872 DTEEGSNKKETQTDSISRYETSSTSA 897
D E+ + + + S+TSA
Sbjct: 1497 DVEQEVPIEPPSATTTTTIGISATSA 1522
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 107 bits (267), Expect = 6e-23
Identities = 71/236 (30%), Positives = 115/236 (48%), Gaps = 10/236 (4%)
Query: 45 LAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDN 104
L A D LL GAD N + DG LH A + + + L+++GA ++ +
Sbjct: 400 LIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQER 459
Query: 105 EGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGV 164
EGW PLH AA + ++A L+ + A +EG TPL +A L++ + QG
Sbjct: 460 EGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVK-LLTSQGA 518
Query: 165 DIEAARKE--------EERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLK 216
+++A ++ ER +R + L SG + D +SG LH AAA+G + K
Sbjct: 519 ELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALD-QSGYGPLHTAAARGKYLICK 577
Query: 217 LLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVA 272
+L++ G + + + GWTPLH AA+ G E +L ++ +M + V T +A
Sbjct: 578 MLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLA 633
Score = 77.4 bits (189), Expect = 6e-14
Identities = 63/239 (26%), Positives = 104/239 (43%), Gaps = 31/239 (12%)
Query: 47 ACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEG 106
A G + LL GA + + G LH A + K L+ GA++ P ++G
Sbjct: 534 AVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQG 593
Query: 107 WIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDI 166
W PLH AA G+L+I L A++GA+ + TPL +A EE + + + + G D
Sbjct: 594 WTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHG-EEAVVSALLQCGADP 652
Query: 167 EAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVN 226
AA + SG T LH+A + + L++ +V+
Sbjct: 653 NAAEQ--------------------------SGWTPLHLAVQRSTFLSVINLLEHHANVH 686
Query: 227 IKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVA----DEDILGYLE 281
++ GWTP H AA G ++LV+ +++ + V T +A + I+ +LE
Sbjct: 687 ARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFLE 745
Score = 63.5 bits (153), Expect = 1e-09
Identities = 48/201 (23%), Positives = 84/201 (41%), Gaps = 27/201 (13%)
Query: 74 LTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVG 133
+T LH +V+ V+ L+ + +++ G+ PL AA D+ L+ GA
Sbjct: 363 VTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADAN 422
Query: 134 AVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDV 193
V+ +G PL A + + AR L+ G D
Sbjct: 423 RVDEDGWAPLHFAAQNGDDGT--------------------------ARLLLDHGACVDA 456
Query: 194 RHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVD 253
+ + G T LH+AA + V +LL+ D N+ + +G TPLH AA++G ++L
Sbjct: 457 QE-REGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTS 515
Query: 254 NLCDMEMVNKVGQTAFDVADE 274
+++ + +T +A E
Sbjct: 516 QGAELDAQQRNLRTPLHLAVE 536
Score = 49.7 bits (117), Expect = 1e-05
Identities = 36/108 (33%), Positives = 52/108 (48%), Gaps = 7/108 (6%)
Query: 198 SGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCD 257
SG T L +AA ++ LL+ G D N D DGW PLH AA G + R+L+D+
Sbjct: 394 SGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGAC 453
Query: 258 MEMVNKVGQTAFDVAD----EDILGYLEELQKKQNLLHSEKRDKKSPL 301
++ + G T +A E++ L Q NL +E K+PL
Sbjct: 454 VDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAE---GKTPL 498
Score = 39.3 bits (90), Expect = 0.019
Identities = 25/80 (31%), Positives = 36/80 (45%)
Query: 56 VLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAAS 115
V+ LL A+++ N G T H A + N ++K LVE GA ++ D PL A
Sbjct: 675 VINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALR 734
Query: 116 CGYLDIAEFLIGQGAHVGAV 135
I FL G+ V +
Sbjct: 735 SRKQGIMSFLEGKEPSVATL 754
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 107 bits (267), Expect = 6e-23
Identities = 78/280 (27%), Positives = 139/280 (49%), Gaps = 9/280 (3%)
Query: 1 MKMADAKQKRNEQLKRWIGSETDLEPPVVKRQKT---KVKFDDGAVFLAACSSGDTDEVL 57
M A ++ K+N L+ I +E + E R+++ K K D A +L A +G ++ L
Sbjct: 1 MAHAASQLKKNRDLE--INAEEEPEKKRKHRKRSRDRKKKSDANASYLRAARAGHLEKAL 58
Query: 58 KLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCG 117
+ G DIN N +GL ALH A + +V++V L++ AN++ +G LH A+ G
Sbjct: 59 DYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAG 118
Query: 118 YLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKE---EE 174
++ + L+ GA+V A + G TPL +A +E E+++ ++ G A ++
Sbjct: 119 QAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLD-NGASQSLATEDGFTPL 177
Query: 175 RIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWT 234
+ L+ + S + + K ALH+AA K T+ LL+Q + +++ G+T
Sbjct: 178 AVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFT 237
Query: 235 PLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVADE 274
PLH AAH+G +L++ ++ + T VA +
Sbjct: 238 PLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASK 277
Score = 103 bits (256), Expect = 1e-21
Identities = 66/221 (29%), Positives = 109/221 (49%), Gaps = 8/221 (3%)
Query: 59 LLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGY 118
LL + A+ N ++G T LH AC + + +++ L+++GA+I G P+H AA G+
Sbjct: 386 LLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGH 445
Query: 119 LDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEE---- 174
++I L+ GA N G+T L +A E+++ V + G +EA K+++
Sbjct: 446 VNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLV-QDGAQVEAKAKDDQTPLH 504
Query: 175 ---RIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYD 231
R+ D Q L + SG T LH++A +G+ +V L+ G ++I
Sbjct: 505 ISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKK 564
Query: 232 GWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVA 272
G+TPLH AA +GK E +L+ + K G T VA
Sbjct: 565 GFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVA 605
Score = 96.3 bits (238), Expect = 1e-19
Identities = 73/251 (29%), Positives = 122/251 (48%), Gaps = 19/251 (7%)
Query: 33 KTKVKFDDGAVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFL 92
+ K K D + ++A G D V +LL +GA N A G T LH + + + D+ FL
Sbjct: 493 EAKAKDDQTPLHISA-RLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFL 551
Query: 93 VENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIA---EEE 149
+++GA+++ +G+ PLH AA G L++A L+ + A A G TPL +A + +
Sbjct: 552 LDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQ 611
Query: 150 AMEELLQNEVNRQGVDIEAARKE--------EERIMLRDARQWLNSG-HINDVRHAKSGG 200
+ LL + QG AA K ++ + A L G N V + G
Sbjct: 612 KVALLLLD----QGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAV--TRQGI 665
Query: 201 TALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEM 260
++H+AA +G+ +++ LL+ +VN+ + G TPLH AA + +LV+ ++
Sbjct: 666 ASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDA 725
Query: 261 VNKVGQTAFDV 271
K+G T V
Sbjct: 726 QTKMGYTPLHV 736
Score = 95.5 bits (236), Expect = 2e-19
Identities = 72/243 (29%), Positives = 109/243 (44%), Gaps = 14/243 (5%)
Query: 47 ACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEG 106
A G + LL + A + A GLT LH A DN + L++ GA+ + G
Sbjct: 572 AAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNG 631
Query: 107 WIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQ---------N 157
+ PLH AA +DIA L+ GA AV +G + +A +E +++ N
Sbjct: 632 YTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVN 691
Query: 158 EVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKL 217
N+ G+ +E+R+ + A +N G D + K G T LHV G +++
Sbjct: 692 LSNKSGLTPLHLAAQEDRVNV--AEVLVNQGAHVDAQ-TKMGYTPLHVGCHYGNIKIVNF 748
Query: 218 LIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVADEDIL 277
L+Q VN K +G+TPLH AA G +L+ N + G TA +A L
Sbjct: 749 LLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARR--L 806
Query: 278 GYL 280
GY+
Sbjct: 807 GYI 809
Score = 93.2 bits (230), Expect = 1e-18
Identities = 70/234 (29%), Positives = 103/234 (44%), Gaps = 10/234 (4%)
Query: 47 ACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEG 106
AC + LL GA I GLT +H A +V++V L+ +GA+ N + G
Sbjct: 407 ACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRG 466
Query: 107 WIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDI 166
LH AA G ++ +L+ GA V A + TPL I+ +++Q ++ +QG
Sbjct: 467 ETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQ-QLLQQGASP 525
Query: 167 EAARKEEERIMLRDARQ--------WLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLL 218
AA + AR+ L+ G + K G T LHVAA G EV LL
Sbjct: 526 NAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSIT-TKKGFTPLHVAAKYGKLEVANLL 584
Query: 219 IQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVA 272
+Q + G TPLH AAH+ ++ +L+D K G T +A
Sbjct: 585 LQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIA 638
Score = 89.4 bits (220), Expect = 2e-17
Identities = 78/300 (26%), Positives = 125/300 (41%), Gaps = 50/300 (16%)
Query: 47 ACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANI------- 99
A G + V +L+H GA N NV G TALH A ++V++LV++GA +
Sbjct: 440 AAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDD 499
Query: 100 --------------------------NQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVG 133
N G+ PLH +A G+ D+A FL+ GA +
Sbjct: 500 QTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLS 559
Query: 134 AVNSEGDTPLDIAEE----EAMEELLQNEVNRQGVDIE-------AARKEEERIMLRDAR 182
+G TPL +A + E LLQ + AA + +++ L
Sbjct: 560 ITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVAL---- 615
Query: 183 QWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHW 242
L+ G + AK+G T LH+AA K ++ L++ G D N G +H AA
Sbjct: 616 LLLDQG-ASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQE 674
Query: 243 GKEEACRILVDNLCDMEMVNKVGQTAFDV-ADEDILGYLEELQKKQNLLHSEKRDKKSPL 301
G + +L+ ++ + NK G T + A ED + E L + + ++ + +PL
Sbjct: 675 GHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPL 734
Score = 84.3 bits (207), Expect = 5e-16
Identities = 69/265 (26%), Positives = 119/265 (44%), Gaps = 13/265 (4%)
Query: 47 ACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEG 106
A G+ + LL+R A +++ + +T LH A N +MVK L++ GA I+ +G
Sbjct: 242 AAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDG 301
Query: 107 WIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEE----EAMEELLQNEVNRQ 162
PLH A G+ + E L+ + A + + G +PL +A + ++ LLQ+ V
Sbjct: 302 LTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVD 361
Query: 163 GV--DIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQ 220
V D A + L N A +G T LH+A K +V++LL++
Sbjct: 362 DVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLK 421
Query: 221 AGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVA----DEDI 276
G + G TP+H AA G L+ + N G+TA +A ++
Sbjct: 422 HGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEV 481
Query: 277 LGYLEELQKKQNLLHSEKRDKKSPL 301
+ YL + + + ++ +D ++PL
Sbjct: 482 VRYLVQDGAQ---VEAKAKDDQTPL 503
Score = 80.5 bits (197), Expect = 8e-15
Identities = 70/258 (27%), Positives = 107/258 (41%), Gaps = 42/258 (16%)
Query: 47 ACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEG 106
A D LL GAD N G+ ++H A + +VDMV L+ AN+N + G
Sbjct: 638 AAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSG 697
Query: 107 WIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDI----AEEEAMEELLQNEVNRQ 162
PLH AA +++AE L+ QGAHV A G TPL + + + LLQ
Sbjct: 698 LTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQ------ 751
Query: 163 GVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAG 222
+S +N K+G T LH AA +G+T ++ +L+Q
Sbjct: 752 -----------------------HSAKVN--AKTKNGYTPLHQAAQQGHTHIINVLLQNN 786
Query: 223 YDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVADEDILGYLEE 282
N +G T L A G +VD L ++V + T V ++ + E
Sbjct: 787 ASPNELTVNGNTALGIARRLGYIS----VVDTL---KIVTEETMTTTTVTEKHKMNVPET 839
Query: 283 LQKKQNLLHSEKRDKKSP 300
+ + ++ E R +P
Sbjct: 840 MNEVLDMSDDEVRKANAP 857
Score = 74.7 bits (182), Expect = 4e-13
Identities = 62/247 (25%), Positives = 110/247 (44%), Gaps = 11/247 (4%)
Query: 34 TKVKFDDGAVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLV 93
TK K A+ +AA DT LL + + + G T LH A N+++ L+
Sbjct: 197 TKGKVRLPALHIAA-RKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLL 255
Query: 94 ENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEE 153
A ++ PLH A+ G ++ + L+ +GA + A +G TPL E+
Sbjct: 256 NRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQ 315
Query: 154 LLQNEVNRQGVDIEAARKEEERIMLRDARQWLN--------SGHINDVRHAKSGGTALHV 205
+++ ++R + + + + LN + ++DV + TALHV
Sbjct: 316 VVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYL--TALHV 373
Query: 206 AAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVG 265
AA G+ +V K+L+ + N K +G+TPLH A + + +L+ + ++ V + G
Sbjct: 374 AAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESG 433
Query: 266 QTAFDVA 272
T VA
Sbjct: 434 LTPIHVA 440
Score = 41.6 bits (96), Expect = 0.004
Identities = 24/79 (30%), Positives = 45/79 (56%)
Query: 197 KSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLC 256
++G ALH+A+ +G+ EV+ L+Q +V+ G T LH A+ G+ E ++LV N
Sbjct: 72 QNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGA 131
Query: 257 DMEMVNKVGQTAFDVADED 275
++ ++ G T +A ++
Sbjct: 132 NVNAQSQNGFTPLYMAAQE 150
Score = 41.2 bits (95), Expect = 0.005
Identities = 48/220 (21%), Positives = 85/220 (38%), Gaps = 34/220 (15%)
Query: 563 ISSSVPSTTSTPTVTSAAGLQKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDS---- 618
I ++ P T P S K S S TK T SS +S + D+
Sbjct: 3867 IKATSPKDTFPPNHMSNTKASKMKQVSQSEKTKALTTSSCVDVKSRIPVKNTHRDNIIAV 3926
Query: 619 -----TEKEKD-------SVPTAVTIPVAPTVVNAAAST--TTLTTTTAGTVSSTTEVRE 664
T+K+ +P+ + + V T V +T TT TTTT T S T +VR+
Sbjct: 3927 RKACATQKQGQPEKGKAKQLPSKLPVKVRSTCVTTTTTTATTTTTTTTTTTTSCTVKVRK 3986
Query: 665 RRRSYL---------------TPVRDEESESQRKARSRQARQSRRSTQGVTLTDLQEAEK 709
+ + + D SE ++K +S + + +++ +L++ +
Sbjct: 3987 SQLKEVCKHSIEYFKGISGETLKLVDRLSEEEKKMQSELSDEEESTSRNTSLSETSRGGQ 4046
Query: 710 TIGRSRSTRTREQENEEKEKEEKEKQDKEKQEEKKESETS 749
++S R ++ E K + EK EK+ ++ S
Sbjct: 4047 PSVTTKSARDKKTE-AAPLKSKSEKAGSEKRSSRRTGPQS 4085
Score = 37.4 bits (85), Expect = 0.073
Identities = 101/544 (18%), Positives = 195/544 (35%), Gaps = 101/544 (18%)
Query: 356 SSEEDEEDDSESEAETDKTKPLASVTNANTSSTQAAPVAVTTPTVSSGQATPTSPIKKFP 415
S+ +++ +S++ D+TKP + +T TPT ++TPTS FP
Sbjct: 3546 SNNRGDDEVFDSKSREDETKPFGLAVEDRSPATTPDTTPARTPT---DESTPTSEPNPFP 3602
Query: 416 ---------TTATKISPKEEERKDESPATWRLGLR----KTGSYGA--LAEITASKEGQK 460
T + I + + +E +++G K+G G + +TA+ + Q
Sbjct: 3603 FHEGKMFEMTRSGAIDMSKRDFVEERLQFFQIGEHTSEGKSGDQGEGDKSMVTATPQPQS 3662
Query: 461 EKDT--AGVTRSASSPRL-------------SSSLDNKEKEKDSKGTRLAYVAPTIPRRL 505
T + R+ +P + + + EK + T + V P + +
Sbjct: 3663 GDTTVETNLERNVETPTVEPNPSIPTSGECQEGTSSSGSLEKSAAATNTSKVDPKLRTPI 3722
Query: 506 -----ASTSDIEEK---ENRDS-SSLRTSSSYTRRKWEDDLKKNSSVNEGSTYHKSCSFG 556
AST ++++ E D ++ TS + + ++ G H+ F
Sbjct: 3723 KMGISASTMTMKKEGPGEITDKIEAVMTSCQGLENETITMISNTANSQMGVRPHEKHDFQ 3782
Query: 557 R----RQDDLISSSVPSTTSTPTVTSAAGLQKSLLSSTSTTTKITTGSSSAGTQS---ST 609
+ ++L SS++ + + + + K+++G + Q
Sbjct: 3783 KDNFNNNNNLDSSTIQTDNIMSNIVLTEHSAPTCTTEKDNPVKVSSGKKTGVLQGHCVRD 3842
Query: 610 SNRLWAEDSTEKEKDSVPTAVTIPVAPT--------------------VVNAAASTTTLT 649
++ E KE + +P+ T V+ + T LT
Sbjct: 3843 KQKVLGEQQKTKELIGIRQKSKLPIKATSPKDTFPPNHMSNTKASKMKQVSQSEKTKALT 3902
Query: 650 TTTAGTVSSTTEVRERRRSYLTPVR----DEESESQRKARSRQ--------ARQSRRSTQ 697
T++ V S V+ R + VR ++ K +++Q R + +T
Sbjct: 3903 TSSCVDVKSRIPVKNTHRDNIIAVRKACATQKQGQPEKGKAKQLPSKLPVKVRSTCVTTT 3962
Query: 698 GVTLTDLQEAEKTIGRSRSTRTREQENEEKEK-----------EEKEKQDKEKQEEKK-E 745
T T T S + + R+ + +E K E + D+ +EEKK +
Sbjct: 3963 TTTATTTTTTTTTTTTSCTVKVRKSQLKEVCKHSIEYFKGISGETLKLVDRLSEEEKKMQ 4022
Query: 746 SETSREDEYKQKYSRTYDETYQRYRPVSTSSS-------TTPSSSLSTMSSSLYASSQLN 798
SE S E+E + + + ET + +P T+ S P S S + S SS+
Sbjct: 4023 SELSDEEESTSR-NTSLSETSRGGQPSVTTKSARDKKTEAAPLKSKSEKAGSEKRSSRRT 4081
Query: 799 RPNS 802
P S
Sbjct: 4082 GPQS 4085
Score = 33.1 bits (74), Expect = 1.4
Identities = 49/243 (20%), Positives = 96/243 (39%), Gaps = 40/243 (16%)
Query: 718 RTREQENEEKEKEEKEKQDKEKQEEKKESETSREDEYKQKYSRTYDETYQR----YRPVS 773
+ +E ++E+KEK + + Q+E + + + +++E+ +E Q
Sbjct: 3335 KLKEVDDEQKEKPKASAEKASNQKELESNGSGKDNEFGLGLDSPQNEIAQNGNNDQSITE 3394
Query: 774 TSSSTTPSSSLSTMSSSLYASSQLNRPNSLVGITSAYSR----------------GITKE 817
S +TT S T ++ + + + + G+T + S+ GI K
Sbjct: 3395 CSIATTAEFSHDTDATEIDSLDGYDLQDEDDGLTESDSKLPIQAMEIKKDIWNTEGILKP 3454
Query: 818 NEREGEK------REEEKEGEDKSQP--KSIRERRRPREKRRSTGVSFWTQDSDENEQEQ 869
+R + EE K G D+ +P KS + P + + +G F+T + ++
Sbjct: 3455 ADRSFSQSKLEVIEEEGKVGPDEDKPPSKSSSSEKTPDKTDQKSGAQFFTLEGRHPDRSV 3514
Query: 870 QSDT-------EEGSNKKETQTDSISRYETSSTSAGDRYDSLLGRSGSYSYLEERKPYSS 922
DT EE + +T ++ S + GD D + S S +E KP+
Sbjct: 3515 FPDTYFSYKVDEEFATPFKTVATKGLDFDPWSNNRGD--DEVF---DSKSREDETKPFGL 3569
Query: 923 RLE 925
+E
Sbjct: 3570 AVE 3572
Score = 32.0 bits (71), Expect = 3.1
Identities = 129/647 (19%), Positives = 224/647 (34%), Gaps = 78/647 (12%)
Query: 374 TKPLASVTNANTSSTQAAPVAVTTPTVSSGQATPTSPIKKFPTTATKISPKEEERKDESP 433
T+P S T A + A T+ + SS SP+K + +T SP
Sbjct: 1500 TRPYQSWTTAPITVPGPAKSGFTSLSSSSSNTPSASPLKSIWSVST-----------PSP 1548
Query: 434 ATWRLGLRKTGSYGALAEITASKEGQKEKDTAGVTRSASSPRLSSSLDNKEKEKDSKGT- 492
LG T S +++++ + R+ SSP + + + S GT
Sbjct: 1549 IKSTLGASTTSSVKSISDVASPIRS---------FRTMSSPIKTVVSQSPYNIQVSSGTL 1599
Query: 493 -RLAYVAPTIP-RRLASTSDIEEKEN--RDSSSLRTSSSYTRRKWEDDLKKNSSVNEGST 548
R V P + LAS S + + + SL SS T S++N S+
Sbjct: 1600 ARAPAVTEATPLKGLASNSTFSSRTSPVTTAGSLLERSSIT---MTPPASPKSNINMYSS 1656
Query: 549 YHKSCSFGRRQDDLISSSVPSTTS--TPTVTSAAGLQKSLLSSTSTTTKITTGSSSAGTQ 606
S LISS + S S V + + ++ SS S+ K G +
Sbjct: 1657 SLPFKSIITSAAPLISSPLKSVVSPVKSAVDVISSAKITMASSLSSPVKQMPGHAEVALV 1716
Query: 607 SSTSNRLWAEDSTEKEKDSVPTAVTIPVAPTVVNAAASTTTLTTTTAGTVSSTTEVR--E 664
+ + + L S+ TA + N+ +S + T T V STT
Sbjct: 1717 NGSISPLKYPSSSTLINGCKATATLQEKISSATNSVSSVVSAATDTVEKVFSTTTAMPFS 1776
Query: 665 RRRSYLTPVRDEESESQRKARSRQARQSRRSTQGVTLTDLQEAEKTIGRSRSTRTREQEN 724
RSY++ +S R + S S+ T + + + T+ +
Sbjct: 1777 PLRSYVS-AAPSAFQSLRTPSASALYTSLGSSISATTSSVTSSIITVPVYSVVNVLPEPA 1835
Query: 725 EEKEKEEKEKQDKEKQEEKKESETSREDEYKQKYSRTYDETYQRYRPVSTSSSTTPSSSL 784
+K + + E + +SRT PV +S PS+
Sbjct: 1836 LKKLPDSNSFTKSAAALLSPIKTLTTETHPQPHFSRTSS-------PVKSSLFLAPSALK 1888
Query: 785 STMSSSLYASSQL-----NRPNSLVGITSAYSRGITKENEREGEKREEEKEGE-DKSQPK 838
+ SSL +S ++ L+ +T+ + +E + E KEG D +P
Sbjct: 1889 LSTPSSLSSSQEILKDVAEMKEDLMRMTAILQTDVPEEKPFQPEL---PKEGRIDDEEPF 1945
Query: 839 SIRERRRPREKRRSTGVSFWTQDSDENEQEQQSDTEEGSNKKETQTDSISRYETSSTSAG 898
I E + +E +N+ +S + + E S E
Sbjct: 1946 KIVE--KVKEDLVKVSEILKKDVCVDNKGSPKSPKSDKGHSPEDDWIEFSSEEIREA--- 2000
Query: 899 DRYDSLLGRSGSYSYLEERKPYSSRLEKDDSTDFKKLYEQILAENEKLKAQLHDTNMELT 958
R + +S S L ER ++ + + K+ + + + + LT
Sbjct: 2001 -RQQAAASQSPS---LPERVQVKAKAASEKDYNLTKVIDYLTND---------IGSSSLT 2047
Query: 959 DLKLQLEKATQRQERFADRSLLEMEKRERRALERRISEMEEELKMLP 1005
+LK + E A + + E+R++R L+ I+ E +LKM P
Sbjct: 2048 NLKYKFEDAKK-----------DGEERQKRVLKPAIALQEHKLKMPP 2083
Score = 31.2 bits (69), Expect = 5.3
Identities = 22/74 (29%), Positives = 36/74 (48%), Gaps = 6/74 (8%)
Query: 346 EEGKKDESSCSSEEDEEDDSESEAETDKT-KPLASVTNANTSSTQAAPVAVTTPTV---- 400
EE KK +S S EE+ + S +ET + +P + +A T+AAP+ +
Sbjct: 4016 EEEKKMQSELSDEEESTSRNTSLSETSRGGQPSVTTKSARDKKTEAAPLKSKSEKAGSEK 4075
Query: 401 -SSGQATPTSPIKK 413
SS + P SP ++
Sbjct: 4076 RSSRRTGPQSPCER 4089
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 107 bits (266), Expect = 8e-23
Identities = 86/284 (30%), Positives = 129/284 (45%), Gaps = 53/284 (18%)
Query: 37 KFDDGAVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNV---------- 86
K D A FL A +G+ D+V++ L G DIN N +GL ALH A + +V
Sbjct: 7 KSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRG 66
Query: 87 -----------------------DMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAE 123
++VK LV+ GANIN G+ PL+ AA ++D+ +
Sbjct: 67 SSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVK 126
Query: 124 FLIGQGAHVGAVNSEGDTPLDIA----EEEAMEELLQNE----VNRQGVDIEAARKEEER 175
+L+ GA+ +G TPL +A +A+ LL+N+ V + I AARK++
Sbjct: 127 YLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHI-AARKDD-- 183
Query: 176 IMLRDARQWLNSGHINDV-------RHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIK 228
+ A L + H DV R +SG T LH+AA G V LL+ G V+
Sbjct: 184 --TKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFT 241
Query: 229 DYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVA 272
+G TPLH A+ G ++L+D ++ + G T A
Sbjct: 242 ARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCA 285
Score = 101 bits (251), Expect = 4e-21
Identities = 79/271 (29%), Positives = 131/271 (48%), Gaps = 25/271 (9%)
Query: 47 ACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEG 106
A G+ + LL+RGA +++ +G+T LH A N +MVK L++ G I+ +G
Sbjct: 219 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDG 278
Query: 107 WIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEE----EAMEELLQNEVNRQ 162
PLH AA G+ + E L+ +GA + A G +PL +A + E ++ LLQ++
Sbjct: 279 LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVD 338
Query: 163 GVDIE-------AARKEEERI--MLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTE 213
V ++ AA R+ +L D R N A +G T LH+A K +
Sbjct: 339 DVTLDYLTALHVAAHCGHYRVTKLLLDKR-------ANPNARALNGFTPLHIACKKNRIK 391
Query: 214 VLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVAD 273
V++LL++ G + G TP+H AA G +L+ N ++ N G+TA +A
Sbjct: 392 VMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAA 451
Query: 274 EDILGYLEE---LQKKQNLLHSEKRDKKSPL 301
G +E L + L+ + R++++PL
Sbjct: 452 R--AGQVEVVRCLLRNGALVDARAREEQTPL 480
Score = 100 bits (248), Expect = 9e-21
Identities = 73/244 (29%), Positives = 112/244 (45%), Gaps = 16/244 (6%)
Query: 47 ACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEG 106
A G D LL R A + A +GLT LH A DN + L+E GA+ + G
Sbjct: 549 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 608
Query: 107 WIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDI 166
+ PLH AA + IA L+ GA V +G TPL +A +E +++ +++ G +I
Sbjct: 609 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDK-GANI 667
Query: 167 EAARK----------EEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLK 216
+ K +E+++ + D L + H K G T L VA G +++
Sbjct: 668 HMSTKSGLTSLHLAAQEDKVNVADI---LTKHGADQDAHTKLGYTPLIVACHYGNVKMVN 724
Query: 217 LLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVADEDI 276
L++ G +VN K +G+TPLH AA G +L+ + G TA +A
Sbjct: 725 FLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKR-- 782
Query: 277 LGYL 280
LGY+
Sbjct: 783 LGYI 786
Score = 92.8 bits (229), Expect = 1e-18
Identities = 70/226 (30%), Positives = 100/226 (44%), Gaps = 27/226 (11%)
Query: 47 ACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEG 106
A G + VL LL GA + N+ G TALH A V++V+ L+ NGA ++ E
Sbjct: 417 AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREE 476
Query: 107 WIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDI 166
PLH A+ G +I + L+ AH A + G TPL I+ E VD+
Sbjct: 477 QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQ------------VDV 524
Query: 167 EAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVN 226
A L +G + + K G T LHVAA G +V KLL+Q +
Sbjct: 525 --------------ASVLLEAGAAHSLA-TKKGFTPLHVAAKYGSLDVAKLLLQRRAAAD 569
Query: 227 IKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVA 272
+G TPLH AAH+ ++ +L++ K G T +A
Sbjct: 570 SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIA 615
Score = 80.9 bits (198), Expect = 6e-15
Identities = 66/222 (29%), Positives = 96/222 (43%), Gaps = 27/222 (12%)
Query: 51 GDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPL 110
G D LL GA + A G T LH A ++D+ K L++ A + G PL
Sbjct: 520 GQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPL 579
Query: 111 HAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAAR 170
H AA +A L+ +GA A G TPL I AA+
Sbjct: 580 HVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHI----------------------AAK 617
Query: 171 KEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDY 230
K + +I A LN G ++ K G T LH+A+ +G+T+++ LL+ G ++++
Sbjct: 618 KNQMQI----ASTLLNYGAETNI-VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTK 672
Query: 231 DGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVA 272
G T LH AA K IL + D + K+G T VA
Sbjct: 673 SGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVA 714
Score = 76.6 bits (187), Expect = 1e-13
Identities = 58/218 (26%), Positives = 94/218 (43%), Gaps = 16/218 (7%)
Query: 66 INYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFL 125
+N G T LH A NV++ L+ GA ++ G PLH A+ G ++ + L
Sbjct: 205 VNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLL 264
Query: 126 IGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWL 185
+ +G + A +G TPL A +++++ + R G + A K L
Sbjct: 265 LDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLER-GAPLLARTKNG----LSPLHMAA 319
Query: 186 NSGHINDVRHAKSGG-----------TALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWT 234
H+ V+H TALHVAA G+ V KLL+ + N + +G+T
Sbjct: 320 QGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFT 379
Query: 235 PLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVA 272
PLH A + + +LV ++ + + G T VA
Sbjct: 380 PLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVA 417
Score = 45.8 bits (107), Expect = 2e-04
Identities = 25/81 (30%), Positives = 40/81 (49%)
Query: 45 LAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDN 104
+ AC G+ V LL +GA++N +G T LHQA + ++ L+++GA N
Sbjct: 712 IVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTA 771
Query: 105 EGWIPLHAAASCGYLDIAEFL 125
G L A GY+ + + L
Sbjct: 772 NGNTALAIAKRLGYISVVDTL 792
>gi|18079216 CASK interacting protein 1 [Homo sapiens]
Length = 1431
Score = 106 bits (265), Expect = 1e-22
Identities = 77/246 (31%), Positives = 124/246 (50%), Gaps = 23/246 (9%)
Query: 32 QKTKVKFDDGAVFLA---ACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDM 88
+K V F D F A A +G+T+ + LL A ++ + G+ LH A +
Sbjct: 38 KKINVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEP 97
Query: 89 VKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEE 148
+K +++ G+ +N P +EG IPLH AA G+ D++E L+ ++ V++ G TPLD+A
Sbjct: 98 MKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLA-- 155
Query: 149 EAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAA 208
E R GV ++ L + R G D +G + LH+AA
Sbjct: 156 --------CEFGRVGV-VQLLLSSNMCAALLEPRP----GDATD----PNGTSPLHLAAK 198
Query: 209 KGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTA 268
G+ ++++LL+QAG D+N + G T LH AA GK E R+L+D+ + + N QTA
Sbjct: 199 NGHIDIIRLLLQAGIDINRQTKSG-TALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTA 257
Query: 269 FDVADE 274
D+ +
Sbjct: 258 LDIVHQ 263
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sapiens]
Length = 2603
Score = 105 bits (263), Expect = 2e-22
Identities = 157/606 (25%), Positives = 243/606 (40%), Gaps = 112/606 (18%)
Query: 45 LAACSSGDTDEVLKLLHRGADIN-YANVDGLTALHQACIDDNVDMVKFLVENGANINQPD 103
+ A +G T V LL G+DIN + TAL AC ++V L++ AN+
Sbjct: 1223 MLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRA 1282
Query: 104 NEGWIPLHAAASCGYLDIAEFLIGQGAHVGA--VNSEGDTPLDIAEEEAMEELLQNEVNR 161
G PL AAS GY ++ L+ +GA V A V S DT L IA ++ + + + R
Sbjct: 1283 KTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGR 1342
Query: 162 QGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQA 221
HI DVR+ K G T L +AA G+ +V++LL+QA
Sbjct: 1343 -------------------------GAHI-DVRN-KKGNTPLWLAANGGHLDVVQLLVQA 1375
Query: 222 GYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVADEDILGYLE 281
G DV+ D TPL AA G + R LV + VN+ +D + + Y+
Sbjct: 1376 GADVDAADNRKITPLMAAFRKGHVKVVRYLV------KEVNQF------PSDSECMRYIA 1423
Query: 282 ELQKKQNLLHSEKRDKKSPL-IESTANMDNNQSQKTFKNKETLIIEPEKNASRIES---- 336
+ K+ L KK L +ES + Q+ + KN L+ E + R ES
Sbjct: 1424 TITDKEML-------KKCHLCMESIVQAKDRQAAEANKNASILLEELDLEKLREESRRLA 1476
Query: 337 --LEQEKVDEEEEGKKDESSCSSEEDEEDDSES-EAETDKTKPLASVTNANTSSTQAAPV 393
++EK E+ KK+E EE E + E+ E + + K V + T+ P
Sbjct: 1477 LAAKREKRKEKRRKKKEEQRRKLEEIEAKNKENFELQAAQEKEKLKVEDEPEVLTE-PPS 1535
Query: 394 AVTTPT--VSSGQATPTSPIKKFPTTATKISPKEEERKDE-SPATWRLGLRK--TGSYGA 448
A TT T +S+ T K T T S K + RK++ +P ++ SY
Sbjct: 1536 ATTTTTIGISATWTTLAGSHGKRNNTITTTSSKRKNRKNKITPENVQIIFDDPLPISYSQ 1595
Query: 449 LAEITASKEGQKEKDTAGVTRSASSPRLSSSLD---NKEKEKDSKGTRLAYVAPTI-PRR 504
++ G+ + + + + + R+SS D N + S A V T+ ++
Sbjct: 1596 PEKV----NGESKSSSTSESGDSDNMRISSCSDESSNSNSSRKSDNHSPAVVTTTVSSKK 1651
Query: 505 LASTSDIEEKENRDSSSLRTSSSYTRRKWEDDLKKNSSVNEGSTYHKSCSFGRRQDDLIS 564
S KE R S S + S +K + +++EG++ S +
Sbjct: 1652 QPSVLVTFPKEERKSVSGKAS-----------IKLSETISEGTSNSLS---------TCT 1691
Query: 565 SSVPSTTSTPTVTSAAGLQKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEKD 624
S PS S+P K+T S G + W E +K
Sbjct: 1692 KSGPSPLSSP------------------NGKLTVASPKRGQKREEG---WKEVVRRSKKV 1730
Query: 625 SVPTAV 630
SVP+ V
Sbjct: 1731 SVPSTV 1736
Score = 96.3 bits (238), Expect = 1e-19
Identities = 84/272 (30%), Positives = 129/272 (47%), Gaps = 37/272 (13%)
Query: 37 KFDDGAVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENG 96
+F + A+ LA C G + V LL GAD + + TAL +AC+D +V++ + L+++G
Sbjct: 399 EFKESALTLA-CYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG 457
Query: 97 ANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQ 156
A +N P + PL AA G++++A LI +GA + VN EG TPL A E EE++
Sbjct: 458 AQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVA 517
Query: 157 NEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLK 216
+ QG +I A +E + TAL +A G+ EV
Sbjct: 518 LLLG-QGANINAQTEETQE-------------------------TALTLACCGGFLEVAD 551
Query: 217 LLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVADE-- 274
LI+AG D+ + TPL AA G E + L+ ++ G TA A E
Sbjct: 552 FLIKAGADIEL---GCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENG 608
Query: 275 --DILGYLEELQKKQNLLHSEKRDKKSPLIES 304
D+ L LQ +L H E ++PL+++
Sbjct: 609 HTDVADVL--LQAGADLEH-ESEGGRTPLMKA 637
Score = 83.2 bits (204), Expect = 1e-15
Identities = 69/218 (31%), Positives = 109/218 (50%), Gaps = 13/218 (5%)
Query: 45 LAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDN 104
+AA + G V LL AD+N + G TAL AC VD+VK L+E+GA+I +
Sbjct: 306 MAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNE 365
Query: 105 EGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSE-GDTPLDIAEEEAMEELLQNEVNRQG 163
G PL A S G++++A L+ GA + ++E ++ L +A + E+++ + G
Sbjct: 366 NGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVR-FLLEAG 424
Query: 164 VDIEAARKEEERIMLRD--------ARQWLNSG-HINDVRHAKSGGTALHVAAAKGYTEV 214
D E E ++ AR L+SG +N A S + L +AA G+ E+
Sbjct: 425 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVN--MPADSFESPLTLAACGGHVEL 482
Query: 215 LKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILV 252
LLI+ G + + +G+TPL AA G EE +L+
Sbjct: 483 AALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLL 520
Score = 80.9 bits (198), Expect = 6e-15
Identities = 64/203 (31%), Positives = 102/203 (50%), Gaps = 10/203 (4%)
Query: 75 TALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGA 134
TAL AC + ++V+ L+E GA+I D +G+ PL AA+ G++ + E L+ GA + A
Sbjct: 1085 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 1144
Query: 135 VNSE-GDTPLDIA----EEEAMEELL---QNEVNRQGVDIEAARKEEERIMLRDARQWLN 186
+ DTPL +A +E +E LL N+ +R D + + LN
Sbjct: 1145 QSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1204
Query: 187 SG-HINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIK-DYDGWTPLHAAAHWGK 244
+G IN +K G + L +AA G+T +KLL+ G D+N + + + T L A G+
Sbjct: 1205 AGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGR 1264
Query: 245 EEACRILVDNLCDMEMVNKVGQT 267
E +L+D ++E K G T
Sbjct: 1265 TEVVSLLLDRKANVEHRAKTGLT 1287
Score = 77.4 bits (189), Expect = 6e-14
Identities = 66/223 (29%), Positives = 105/223 (47%), Gaps = 12/223 (5%)
Query: 47 ACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANIN-QPDNE 105
AC+ G + V LL RGA I + + G T L A +V +V+ L++NGA+I Q +
Sbjct: 1090 ACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERT 1149
Query: 106 GWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVD 165
PL A S G ++ E L+ +GA+ N TPL +A +++ +N G +
Sbjct: 1150 KDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN-AGAE 1208
Query: 166 IEAARKEE---ERIML-------RDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVL 215
I + + +ML + L+ G + + + TAL +A +G TEV+
Sbjct: 1209 INSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVV 1268
Query: 216 KLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDM 258
LL+ +V + G TPL AA G E R+L+D D+
Sbjct: 1269 SLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADV 1311
Score = 75.1 bits (183), Expect = 3e-13
Identities = 66/234 (28%), Positives = 104/234 (44%), Gaps = 18/234 (7%)
Query: 47 ACSSGDTDEVLKLLHRGADINYANVDG-LTALHQACIDDNVDMVKFLVENGANINQPDNE 105
ACS+G + LL A++ + G +T L A +V +VK L+ + A++N +
Sbjct: 274 ACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSST 333
Query: 106 GWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEV-NRQGV 164
G L A + GY+D+ + L+ GA + N G TPL A E+ + + N G+
Sbjct: 334 GNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGI 393
Query: 165 DIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGG-----------TALHVAAAKGYTE 213
+ + +E + L GH+ VR G TAL A G+ E
Sbjct: 394 NTHSNEFKESALTLA-----CYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVE 448
Query: 214 VLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQT 267
V +LL+ +G VN+ +PL AA G E +L++ +E VN G T
Sbjct: 449 VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYT 502
Score = 67.0 bits (162), Expect = 9e-11
Identities = 59/232 (25%), Positives = 102/232 (43%), Gaps = 41/232 (17%)
Query: 25 EPPVVKRQKTKVKFDDGAVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDD 84
+P V++R + V +C+ + L + + N D +L +AC +
Sbjct: 197 DPEVLRRLTSSV----------SCALDEAAAALTRMRAESTANAGQSDN-RSLAEACSEG 245
Query: 85 NVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGD-TPL 143
+V+ V+ L+ G ++N+ EG L A S GY ++A+ L+ A+V +GD TPL
Sbjct: 246 DVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPL 305
Query: 144 DIAEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVR-HAKSGGTA 202
A ++++ L H DV + +G TA
Sbjct: 306 MAAANGGHVKIVK----------------------------LLLAHKADVNAQSSTGNTA 337
Query: 203 LHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDN 254
L A A GY +V+K+L+++G + + +G TPL A G E R+L++N
Sbjct: 338 LTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLEN 389
Score = 56.2 bits (134), Expect = 2e-07
Identities = 78/337 (23%), Positives = 130/337 (38%), Gaps = 38/337 (11%)
Query: 45 LAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDN 104
+ A G + V LL GA+++ G TAL AC + + D+ L++ GA++
Sbjct: 569 MEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESE 628
Query: 105 EGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGD-TPLDIA---EEEAMEELLQNEVN 160
G PL AA G++ +FLI +GA+V + D T L +A A+ ELL
Sbjct: 629 GGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELL----- 683
Query: 161 RQGVDIEAARKEEERIMLRDARQWLNSGHINDVRH-AKSGGTALHVAAAKGYTEVLKLLI 219
H D H K G T L AA G+T V+ L+
Sbjct: 684 --------------------------LAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLL 717
Query: 220 QAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVADE-DILG 278
++ T L +H A R+ V L + + + +VA I
Sbjct: 718 DYPNNLLSAPPPDVTQLTPPSH-DLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRN 776
Query: 279 YLEELQKKQNLLHSEKRDKKSPLIESTANMDNNQSQKTFKNKETLIIEPEKNASRIESLE 338
QK + L + +D + + + ++Q E I E + ++++SLE
Sbjct: 777 KAASKQKSSSHLPANSQDVQGYITNQSPESIVEEAQGKLTELEQRIKEAIEKNAQLQSLE 836
Query: 339 QEKVDEEEEGKKDESSCSSEEDEEDDSESEAETDKTK 375
D+ + K +E + + EE + + E K +
Sbjct: 837 LAHADQLTKEKIEELNKTREEQIQKKQKILEELQKVE 873
Score = 43.5 bits (101), Expect = 0.001
Identities = 24/68 (35%), Positives = 38/68 (55%)
Query: 192 DVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRIL 251
D + + TAL +A A G+ E+++ L++ G + +D G+TPL AA G IL
Sbjct: 1076 DAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEIL 1135
Query: 252 VDNLCDME 259
+DN D+E
Sbjct: 1136 LDNGADIE 1143
Score = 40.8 bits (94), Expect = 0.007
Identities = 55/268 (20%), Positives = 116/268 (43%), Gaps = 31/268 (11%)
Query: 669 YLTPVRDEES--------ESQRKARSRQARQSRRSTQGVTLTDLQEAEKTIGRSRSTRTR 720
Y+ + D+E ES +A+ RQA ++ ++ + L+E + R S R
Sbjct: 1421 YIATITDKEMLKKCHLCMESIVQAKDRQAAEANKNASIL----LEELDLEKLREESRRLA 1476
Query: 721 EQENEEKEKEEKEKQDKEKQEEKKESETSREDEYKQKYSRTYDETYQRYRP----VSTSS 776
EK KE++ K+ +E++ + +E E ++ ++ + ++ ++ P S+
Sbjct: 1477 LAAKREKRKEKRRKKKEEQRRKLEEIEAKNKENFELQAAQEKEKLKVEDEPEVLTEPPSA 1536
Query: 777 STTPSSSLSTMSSSLYASSQLNRPNSLVGITSAYSRGITKENEREGEKREEEKEGEDKSQ 836
+TT + +S ++L A S R N++ +S ++N + E + D
Sbjct: 1537 TTTTTIGISATWTTL-AGSHGKRNNTITTTSS------KRKNRKNKITPENVQIIFDDPL 1589
Query: 837 PKSIRERRRPREKRRSTGVSFWTQDSDENEQEQQSDTEEGSNKKET-QTDSISRYETSST 895
P S + + + +S+ S + D + S ++E SN + ++D+ S ++T
Sbjct: 1590 PISYSQPEKVNGESKSSSTS---ESGDSDNMRISSCSDESSNSNSSRKSDNHSPAVVTTT 1646
Query: 896 SAGDRYDSLLGRSGSYSYLEERKPYSSR 923
+ + S+L EERK S +
Sbjct: 1647 VSSKKQPSVLVTFPK----EERKSVSGK 1670
Score = 37.4 bits (85), Expect = 0.073
Identities = 28/106 (26%), Positives = 49/106 (46%), Gaps = 12/106 (11%)
Query: 179 RDARQWLNSGHINDVR-----------HAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNI 227
R + + G +N VR H + G + L +A + GY E+ ++L+ +V
Sbjct: 236 RSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVED 295
Query: 228 KDYDG-WTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVA 272
+ G TPL AAA+ G + ++L+ + D+ + G TA A
Sbjct: 296 RGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYA 341
Score = 35.0 bits (79), Expect = 0.36
Identities = 31/131 (23%), Positives = 57/131 (43%), Gaps = 8/131 (6%)
Query: 620 EKEKDSVPTAVTIPVAPTVVNAAASTTTLTTTTAG-----TVSSTTEVRERRRSYLTPVR 674
E +K A T+P+ + S++ L + T S + E + LT +
Sbjct: 760 EPDKPPANVATTLPIRNKAASKQKSSSHLPANSQDVQGYITNQSPESIVEEAQGKLTELE 819
Query: 675 DEESESQRKARSRQARQSRRSTQGVTLTDLQEAEKTIGRSRSTRTREQENEEKEKEEKEK 734
E+ K Q+ + + Q +T ++E KT R + +++ EE +K E+E
Sbjct: 820 QRIKEAIEKNAQLQSLELAHADQ-LTKEKIEELNKT--REEQIQKKQKILEELQKVEREL 876
Query: 735 QDKEKQEEKKE 745
Q K +Q+ KK+
Sbjct: 877 QLKTQQQLKKQ 887
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sapiens]
Length = 2352
Score = 105 bits (263), Expect = 2e-22
Identities = 157/606 (25%), Positives = 243/606 (40%), Gaps = 112/606 (18%)
Query: 45 LAACSSGDTDEVLKLLHRGADIN-YANVDGLTALHQACIDDNVDMVKFLVENGANINQPD 103
+ A +G T V LL G+DIN + TAL AC ++V L++ AN+
Sbjct: 972 MLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRA 1031
Query: 104 NEGWIPLHAAASCGYLDIAEFLIGQGAHVGA--VNSEGDTPLDIAEEEAMEELLQNEVNR 161
G PL AAS GY ++ L+ +GA V A V S DT L IA ++ + + + R
Sbjct: 1032 KTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGR 1091
Query: 162 QGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQA 221
HI DVR+ K G T L +AA G+ +V++LL+QA
Sbjct: 1092 -------------------------GAHI-DVRN-KKGNTPLWLAANGGHLDVVQLLVQA 1124
Query: 222 GYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVADEDILGYLE 281
G DV+ D TPL AA G + R LV + VN+ +D + + Y+
Sbjct: 1125 GADVDAADNRKITPLMAAFRKGHVKVVRYLV------KEVNQF------PSDSECMRYIA 1172
Query: 282 ELQKKQNLLHSEKRDKKSPL-IESTANMDNNQSQKTFKNKETLIIEPEKNASRIES---- 336
+ K+ L KK L +ES + Q+ + KN L+ E + R ES
Sbjct: 1173 TITDKEML-------KKCHLCMESIVQAKDRQAAEANKNASILLEELDLEKLREESRRLA 1225
Query: 337 --LEQEKVDEEEEGKKDESSCSSEEDEEDDSES-EAETDKTKPLASVTNANTSSTQAAPV 393
++EK E+ KK+E EE E + E+ E + + K V + T+ P
Sbjct: 1226 LAAKREKRKEKRRKKKEEQRRKLEEIEAKNKENFELQAAQEKEKLKVEDEPEVLTE-PPS 1284
Query: 394 AVTTPT--VSSGQATPTSPIKKFPTTATKISPKEEERKDE-SPATWRLGLRK--TGSYGA 448
A TT T +S+ T K T T S K + RK++ +P ++ SY
Sbjct: 1285 ATTTTTIGISATWTTLAGSHGKRNNTITTTSSKRKNRKNKITPENVQIIFDDPLPISYSQ 1344
Query: 449 LAEITASKEGQKEKDTAGVTRSASSPRLSSSLD---NKEKEKDSKGTRLAYVAPTI-PRR 504
++ G+ + + + + + R+SS D N + S A V T+ ++
Sbjct: 1345 PEKV----NGESKSSSTSESGDSDNMRISSCSDESSNSNSSRKSDNHSPAVVTTTVSSKK 1400
Query: 505 LASTSDIEEKENRDSSSLRTSSSYTRRKWEDDLKKNSSVNEGSTYHKSCSFGRRQDDLIS 564
S KE R S S + S +K + +++EG++ S +
Sbjct: 1401 QPSVLVTFPKEERKSVSGKAS-----------IKLSETISEGTSNSLS---------TCT 1440
Query: 565 SSVPSTTSTPTVTSAAGLQKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEKD 624
S PS S+P K+T S G + W E +K
Sbjct: 1441 KSGPSPLSSP------------------NGKLTVASPKRGQKREEG---WKEVVRRSKKV 1479
Query: 625 SVPTAV 630
SVP+ V
Sbjct: 1480 SVPSTV 1485
Score = 96.3 bits (238), Expect = 1e-19
Identities = 84/272 (30%), Positives = 129/272 (47%), Gaps = 37/272 (13%)
Query: 37 KFDDGAVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENG 96
+F + A+ LA C G + V LL GAD + + TAL +AC+D +V++ + L+++G
Sbjct: 399 EFKESALTLA-CYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG 457
Query: 97 ANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQ 156
A +N P + PL AA G++++A LI +GA + VN EG TPL A E EE++
Sbjct: 458 AQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVA 517
Query: 157 NEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLK 216
+ QG +I A +E + TAL +A G+ EV
Sbjct: 518 LLLG-QGANINAQTEETQE-------------------------TALTLACCGGFLEVAD 551
Query: 217 LLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVADE-- 274
LI+AG D+ + TPL AA G E + L+ ++ G TA A E
Sbjct: 552 FLIKAGADIEL---GCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENG 608
Query: 275 --DILGYLEELQKKQNLLHSEKRDKKSPLIES 304
D+ L LQ +L H E ++PL+++
Sbjct: 609 HTDVADVL--LQAGADLEH-ESEGGRTPLMKA 637
Score = 83.2 bits (204), Expect = 1e-15
Identities = 69/218 (31%), Positives = 109/218 (50%), Gaps = 13/218 (5%)
Query: 45 LAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDN 104
+AA + G V LL AD+N + G TAL AC VD+VK L+E+GA+I +
Sbjct: 306 MAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNE 365
Query: 105 EGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSE-GDTPLDIAEEEAMEELLQNEVNRQG 163
G PL A S G++++A L+ GA + ++E ++ L +A + E+++ + G
Sbjct: 366 NGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVR-FLLEAG 424
Query: 164 VDIEAARKEEERIMLRD--------ARQWLNSG-HINDVRHAKSGGTALHVAAAKGYTEV 214
D E E ++ AR L+SG +N A S + L +AA G+ E+
Sbjct: 425 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVN--MPADSFESPLTLAACGGHVEL 482
Query: 215 LKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILV 252
LLI+ G + + +G+TPL AA G EE +L+
Sbjct: 483 AALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLL 520
Score = 80.9 bits (198), Expect = 6e-15
Identities = 64/203 (31%), Positives = 102/203 (50%), Gaps = 10/203 (4%)
Query: 75 TALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGA 134
TAL AC + ++V+ L+E GA+I D +G+ PL AA+ G++ + E L+ GA + A
Sbjct: 834 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 893
Query: 135 VNSE-GDTPLDIA----EEEAMEELL---QNEVNRQGVDIEAARKEEERIMLRDARQWLN 186
+ DTPL +A +E +E LL N+ +R D + + LN
Sbjct: 894 QSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 953
Query: 187 SG-HINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIK-DYDGWTPLHAAAHWGK 244
+G IN +K G + L +AA G+T +KLL+ G D+N + + + T L A G+
Sbjct: 954 AGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGR 1013
Query: 245 EEACRILVDNLCDMEMVNKVGQT 267
E +L+D ++E K G T
Sbjct: 1014 TEVVSLLLDRKANVEHRAKTGLT 1036
Score = 77.4 bits (189), Expect = 6e-14
Identities = 66/223 (29%), Positives = 105/223 (47%), Gaps = 12/223 (5%)
Query: 47 ACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANIN-QPDNE 105
AC+ G + V LL RGA I + + G T L A +V +V+ L++NGA+I Q +
Sbjct: 839 ACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERT 898
Query: 106 GWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVD 165
PL A S G ++ E L+ +GA+ N TPL +A +++ +N G +
Sbjct: 899 KDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN-AGAE 957
Query: 166 IEAARKEE---ERIML-------RDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVL 215
I + + +ML + L+ G + + + TAL +A +G TEV+
Sbjct: 958 INSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVV 1017
Query: 216 KLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDM 258
LL+ +V + G TPL AA G E R+L+D D+
Sbjct: 1018 SLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADV 1060
Score = 75.1 bits (183), Expect = 3e-13
Identities = 66/234 (28%), Positives = 104/234 (44%), Gaps = 18/234 (7%)
Query: 47 ACSSGDTDEVLKLLHRGADINYANVDG-LTALHQACIDDNVDMVKFLVENGANINQPDNE 105
ACS+G + LL A++ + G +T L A +V +VK L+ + A++N +
Sbjct: 274 ACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSST 333
Query: 106 GWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEV-NRQGV 164
G L A + GY+D+ + L+ GA + N G TPL A E+ + + N G+
Sbjct: 334 GNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGI 393
Query: 165 DIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGG-----------TALHVAAAKGYTE 213
+ + +E + L GH+ VR G TAL A G+ E
Sbjct: 394 NTHSNEFKESALTLA-----CYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVE 448
Query: 214 VLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQT 267
V +LL+ +G VN+ +PL AA G E +L++ +E VN G T
Sbjct: 449 VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYT 502
Score = 67.0 bits (162), Expect = 9e-11
Identities = 59/232 (25%), Positives = 102/232 (43%), Gaps = 41/232 (17%)
Query: 25 EPPVVKRQKTKVKFDDGAVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDD 84
+P V++R + V +C+ + L + + N D +L +AC +
Sbjct: 197 DPEVLRRLTSSV----------SCALDEAAAALTRMRAESTANAGQSDN-RSLAEACSEG 245
Query: 85 NVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGD-TPL 143
+V+ V+ L+ G ++N+ EG L A S GY ++A+ L+ A+V +GD TPL
Sbjct: 246 DVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPL 305
Query: 144 DIAEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVR-HAKSGGTA 202
A ++++ L H DV + +G TA
Sbjct: 306 MAAANGGHVKIVK----------------------------LLLAHKADVNAQSSTGNTA 337
Query: 203 LHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDN 254
L A A GY +V+K+L+++G + + +G TPL A G E R+L++N
Sbjct: 338 LTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLEN 389
Score = 54.3 bits (129), Expect = 6e-07
Identities = 33/103 (32%), Positives = 52/103 (50%), Gaps = 1/103 (0%)
Query: 45 LAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDN 104
+ A G + V LL GA+++ G TAL AC + + D+ L++ GA++
Sbjct: 569 MEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESE 628
Query: 105 EGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGD-TPLDIA 146
G PL AA G++ +FLI +GA+V + D T L +A
Sbjct: 629 GGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLA 671
Score = 43.5 bits (101), Expect = 0.001
Identities = 24/68 (35%), Positives = 38/68 (55%)
Query: 192 DVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRIL 251
D + + TAL +A A G+ E+++ L++ G + +D G+TPL AA G IL
Sbjct: 825 DAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEIL 884
Query: 252 VDNLCDME 259
+DN D+E
Sbjct: 885 LDNGADIE 892
Score = 40.8 bits (94), Expect = 0.007
Identities = 55/268 (20%), Positives = 116/268 (43%), Gaps = 31/268 (11%)
Query: 669 YLTPVRDEES--------ESQRKARSRQARQSRRSTQGVTLTDLQEAEKTIGRSRSTRTR 720
Y+ + D+E ES +A+ RQA ++ ++ + L+E + R S R
Sbjct: 1170 YIATITDKEMLKKCHLCMESIVQAKDRQAAEANKNASIL----LEELDLEKLREESRRLA 1225
Query: 721 EQENEEKEKEEKEKQDKEKQEEKKESETSREDEYKQKYSRTYDETYQRYRP----VSTSS 776
EK KE++ K+ +E++ + +E E ++ ++ + ++ ++ P S+
Sbjct: 1226 LAAKREKRKEKRRKKKEEQRRKLEEIEAKNKENFELQAAQEKEKLKVEDEPEVLTEPPSA 1285
Query: 777 STTPSSSLSTMSSSLYASSQLNRPNSLVGITSAYSRGITKENEREGEKREEEKEGEDKSQ 836
+TT + +S ++L A S R N++ +S ++N + E + D
Sbjct: 1286 TTTTTIGISATWTTL-AGSHGKRNNTITTTSS------KRKNRKNKITPENVQIIFDDPL 1338
Query: 837 PKSIRERRRPREKRRSTGVSFWTQDSDENEQEQQSDTEEGSNKKET-QTDSISRYETSST 895
P S + + + +S+ S + D + S ++E SN + ++D+ S ++T
Sbjct: 1339 PISYSQPEKVNGESKSSSTS---ESGDSDNMRISSCSDESSNSNSSRKSDNHSPAVVTTT 1395
Query: 896 SAGDRYDSLLGRSGSYSYLEERKPYSSR 923
+ + S+L EERK S +
Sbjct: 1396 VSSKKQPSVLVTFPK----EERKSVSGK 1419
Score = 37.4 bits (85), Expect = 0.073
Identities = 28/106 (26%), Positives = 49/106 (46%), Gaps = 12/106 (11%)
Query: 179 RDARQWLNSGHINDVR-----------HAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNI 227
R + + G +N VR H + G + L +A + GY E+ ++L+ +V
Sbjct: 236 RSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVED 295
Query: 228 KDYDG-WTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVA 272
+ G TPL AAA+ G + ++L+ + D+ + G TA A
Sbjct: 296 RGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYA 341
Score = 30.4 bits (67), Expect = 9.0
Identities = 21/83 (25%), Positives = 40/83 (48%), Gaps = 1/83 (1%)
Query: 45 LAACSSGDTDEVLKLLHRGADINYANVDG-LTALHQACIDDNVDMVKFLVENGANINQPD 103
+ A +G V L+ +GA++N + T L AC ++ +V+ L+ +GA+
Sbjct: 635 MKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRL 694
Query: 104 NEGWIPLHAAASCGYLDIAEFLI 126
+G L AA G+ + +L+
Sbjct: 695 KDGSTMLIEAAKGGHTSVVCYLL 717
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 103 bits (257), Expect = 8e-22
Identities = 76/241 (31%), Positives = 117/241 (48%), Gaps = 14/241 (5%)
Query: 12 EQLKRWIGSETDLEPPVVKRQKTKVKFDDGAVFLAACSSGDTDEVLKLLHRGADINYANV 71
E++KR + E R+ T + F A G D V LL GA++ +
Sbjct: 38 ERVKRLVTPEKVNSRDTAGRKSTPLHF--------AAGFGRKDVVEYLLQNGANVQARDD 89
Query: 72 DGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAH 131
GL LH AC + ++V L+ +GA+ N DN + PLH AA G +D+ L+ GA
Sbjct: 90 GGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAE 149
Query: 132 VGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHIN 191
N++G T LD+A+ A + +L E + + +E+AR E M+ + H +
Sbjct: 150 PTIRNTDGRTALDLADPSA-KAVLTGEYKKDEL-LESARSGNEEKMMALLTPLNVNCHAS 207
Query: 192 DVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRIL 251
D R + T LH+AA ++++LL+Q G DV+ KD PLH A +G E +L
Sbjct: 208 DGRKS----TPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELL 263
Query: 252 V 252
V
Sbjct: 264 V 264
Score = 100 bits (250), Expect = 5e-21
Identities = 74/246 (30%), Positives = 119/246 (48%), Gaps = 31/246 (12%)
Query: 59 LLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGY 118
LL GAD++ + GL LH AC + ++ + LV++GA +N D + PLH AA+ G
Sbjct: 545 LLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGK 604
Query: 119 LDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARK------- 171
+I + L+ GA N +G+TPLD+ ++ + +Q+ + ++AA+K
Sbjct: 605 YEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTD--IQDLLRGDAALLDAAKKGCLARVK 662
Query: 172 ---EEERIMLRDAR------QWLNSGHIN------------DVRHAKSGG-TALHVAAAK 209
+ + RD + L +G+ N DV GG LH AA+
Sbjct: 663 KLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASY 722
Query: 210 GYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAF 269
G+ +V LLI+ VN D +TPLH AA G+ + C +L+ + D + N+ GQT
Sbjct: 723 GHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPL 782
Query: 270 DVADED 275
D+ D
Sbjct: 783 DLVSAD 788
Score = 97.4 bits (241), Expect = 6e-20
Identities = 82/272 (30%), Positives = 127/272 (46%), Gaps = 37/272 (13%)
Query: 59 LLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGY 118
LL +GA+IN + LT LH A + D+V+ +V++ A +N DN G LH AA CG+
Sbjct: 386 LLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGH 445
Query: 119 LDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQ-------NEVNRQ------GVD 165
L L+ G ++ +G T L + E +++LLQ +E +RQ D
Sbjct: 446 LQTCRLLLSYGCDPNIISLQGFTALQMGNEN-VQQLLQEGISLGNSEADRQLLEAAKAGD 504
Query: 166 IEAARK--EEERIMLRDARQWLNS------------------GHINDVRHAKSGG--TAL 203
+E +K + + RD ++ H DV HAK G L
Sbjct: 505 VETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADV-HAKDKGGLVPL 563
Query: 204 HVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNK 263
H A + G+ EV +LL++ G VN+ D +TPLH AA GK E C++L+ + D N+
Sbjct: 564 HNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNR 623
Query: 264 VGQTAFDVADEDILGYLEELQKKQNLLHSEKR 295
G T D+ + + L+ LL + K+
Sbjct: 624 DGNTPLDLVKDGDTDIQDLLRGDAALLDAAKK 655
Score = 93.2 bits (230), Expect = 1e-18
Identities = 68/255 (26%), Positives = 118/255 (46%), Gaps = 32/255 (12%)
Query: 59 LLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGY 118
LL GAD++ + L LH AC + ++ + LV++GA +N D + PLH AAS
Sbjct: 230 LLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNR 289
Query: 119 LDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEE-ERIM 177
+++ L+ GA +N + +D+A ++E L E + ++AAR+ + RI
Sbjct: 290 VEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSL-LQAAREADVTRIK 348
Query: 178 LRDARQWLNSGH------------------------------INDVRHAKSGGTALHVAA 207
+ + +N H N K T LHVA+
Sbjct: 349 KHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVAS 408
Query: 208 AKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQT 267
K + +V++++++ VN D G T LH AA+ G + CR+L+ CD +++ G T
Sbjct: 409 EKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFT 468
Query: 268 AFDVADEDILGYLEE 282
A + +E++ L+E
Sbjct: 469 ALQMGNENVQQLLQE 483
Score = 65.5 bits (158), Expect = 3e-10
Identities = 71/278 (25%), Positives = 104/278 (37%), Gaps = 64/278 (23%)
Query: 77 LHQACIDDNVDMVKFLVENGANINQPDNEGW--IPLHAAASCGYLDIAEFLIGQGAHVGA 134
L +AC + +V+ VK LV +N D G PLH AA G D+ E+L
Sbjct: 28 LFEACRNGDVERVKRLV-TPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYL--------- 77
Query: 135 VNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVR 194
LQN N Q D
Sbjct: 78 --------------------LQNGANVQARD----------------------------- 88
Query: 195 HAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDN 254
G LH A + G+ EV+ LL++ G D N +D +TPLH AA GK + C +L+ +
Sbjct: 89 --DGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQH 146
Query: 255 LCDMEMVNKVGQTAFDVADEDILGYLEELQKKQNLLHSEKRDKKSPLIESTANMDNNQSQ 314
+ + N G+TA D+AD L KK LL S + + ++ ++ N
Sbjct: 147 GAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHA 206
Query: 315 KTFKNKETLIIEPEKNASRI-ESLEQEKVDEEEEGKKD 351
+ L + N +I + L Q D + K D
Sbjct: 207 SDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGD 244
Score = 65.1 bits (157), Expect = 3e-10
Identities = 35/97 (36%), Positives = 48/97 (49%)
Query: 59 LLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGY 118
LL GAD+N + GL LH A +VD+ L++ A +N D + PLH AA G
Sbjct: 698 LLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGR 757
Query: 119 LDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELL 155
+ L+ GA N EG TPLD+ + + LL
Sbjct: 758 TQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALL 794
>gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]
Length = 2039
Score = 103 bits (256), Expect = 1e-21
Identities = 201/1039 (19%), Positives = 400/1039 (38%), Gaps = 134/1039 (12%)
Query: 26 PPVVKRQKTKV--KFDDGAVFL-AACSSGDTDEVLKLLHRGADINYANVDGLTALHQACI 82
P RQK KV + + G L A GD +V +L+ GA++N + G T LH+AC
Sbjct: 145 PSSSSRQKDKVNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACN 204
Query: 83 DDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTP 142
D+ K L+ GA++N + PLH +AS G+ DI + L+ G + N G+ P
Sbjct: 205 VGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERP 264
Query: 143 LDIAEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTA 202
+D+AE E +E LL+ EV D EE Q +N +++ +++ +
Sbjct: 265 VDVAETEELELLLKREVPLSDDDESYTDSEE--------AQSVNPSSVDENIDSETEKDS 316
Query: 203 LHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVN 262
L + +K L A + KD D +E ++D D ++
Sbjct: 317 L-ICESKQILPSKTPLPSALDEYEFKDDD-------------DEEINKMID---DRHILR 359
Query: 263 KVGQTAFDVADEDILGYLEELQKKQNLLHSEKRDKKSPLIESTANMDNNQSQKTFKNKET 322
K + + E + ++ + K+ K S ++ S+ + ++ + K +
Sbjct: 360 KEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTS 419
Query: 323 LIIEPEKNASRIESLEQEKVDEEEEGK-----KDESSCSSEEDEEDDSESEAE------- 370
+ PE + S +++ ++ V E + K K ++ ++E++E E E +
Sbjct: 420 CSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITN 479
Query: 371 ---------TDKTKP----LASVTNANTSSTQAAPVAV-TTPTVSSGQATPTSPIKKFPT 416
++KT+ S + + +S ++ +P S G + S K
Sbjct: 480 LTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEH 539
Query: 417 TATKISPKEEERKDESPATWRLGLRKTGSYGALAEITASKEGQK------------EKDT 464
T T +SP E + P R ++ + + + K +K EK
Sbjct: 540 TKTCLSPGSSEMSLQ-PDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSN 598
Query: 465 AGVTRSASSPRL-SSSLDNKEKEKDSKGTRLAYVAPTIPRRLASTSDIE-EKE---NRDS 519
A + SP +S K+ +K+ K + + + +IE EKE +DS
Sbjct: 599 AKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDS 658
Query: 520 S-SLRTSSSYTRRKWEDDLKKNSSVNE--GSTYHKSCSFGRRQDDLISSSVPSTTSTPTV 576
+ L+ S + R W+++ K+ + + H+S + ++ + +T V
Sbjct: 659 AKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHV 718
Query: 577 TSAAGLQKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVPTAVTIPVAP 636
+ ++ KI S + + + ++ +KDS T++ +
Sbjct: 719 SKERNFKEE-------RDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIE 771
Query: 637 TVVNAAASTTTLTTTTAGTVSSTTEVRERRRSYLTPVRDEESESQRKARSRQARQSRRST 696
+ + ++ + +RS + E+ E + + ++ + +S
Sbjct: 772 ESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSE 831
Query: 697 Q-----GVTLTDLQEAEKTIGRSRSTRTREQENEEKEKEEKEKQDKEKQEEKKESETSRE 751
+ + ++E +K +E E + K+ D+EK EK + + +E
Sbjct: 832 KDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKE 891
Query: 752 DEYKQKYSRTYDETYQRYRPVSTSSSTTPSSSLSTMSSSLYASSQLNRPNSLVGITSAYS 811
K+++ E + + S ++ S S
Sbjct: 892 KPEKERHLAESKEKHLMEKKNKQSDNSEYSKS---------------------------E 924
Query: 812 RGITKENEREGEKREE--EKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQEQ 869
+G KE +RE +K+E+ +KE + + K I+E ++ + E +++
Sbjct: 925 KGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDE 984
Query: 870 QSDTEEGSNKKETQTDSISRY-ETSSTSAGDRYDSLLGRSGSYSYLEERKPYSSRLEKDD 928
T +G K + D I RY E + +SLL S ++ KP SS KD
Sbjct: 985 PLKTPDGKEKDKKDKD-IDRYKERDKHKDKIQINSLLKLK---SEADKPKPKSSPASKDT 1040
Query: 929 STDFKKLYEQILAENEKLKAQLHDTNMELTDLKLQ------LEKATQRQ-ERFADRSLLE 981
K+L N+ L + + L DL+++ EK Q++ ER +R+ LE
Sbjct: 1041 RPKEKRLV------NDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLE 1094
Query: 982 MEKRERRALERRISEMEEE 1000
++ +++ + +E + +
Sbjct: 1095 LKIKDKEKTKHTPTESKNK 1113
Score = 45.4 bits (106), Expect = 3e-04
Identities = 161/855 (18%), Positives = 303/855 (35%), Gaps = 151/855 (17%)
Query: 300 PLIESTANMDNNQSQKTFKNKETLIIEPEKNASRIESLEQEKVDEEEEGKKDE----SSC 355
P+ ++ D+N +K + K I +IE + K +E+ K + S
Sbjct: 9 PIQSENSDSDSNMVEKPYGRKSKDKIASYSKTPKIERSDVSKEMKEKSSMKRKLPFTISP 68
Query: 356 SSEEDEEDDSESEA-ETDKTKPLASVTNANTSS----------TQAAPVAVTTPTVSSGQ 404
S E+ + D+E E E KTK A + S Q A + T +S
Sbjct: 69 SRNEERDSDTEKEGPEKKKTKKEAGNKKSTPVSILFGYPLSERKQMALLMQMTARDNSPD 128
Query: 405 ATPTSPI------KKFPTTATKISPKEEERKDESPATWRLGLRKTGSYGALAEITASKEG 458
+TP P KK P+++++ K +R + + + G + E+ +
Sbjct: 129 STPNHPSQTTPAQKKTPSSSSRQKDKVNKRNERGETPLHMAAIR-GDVKQVKELISLGAN 187
Query: 459 QKEKDTAGVTR-----------------SASSPRLSSSLDNKEKEKDSKGTRLAYVAPTI 501
KD AG T +A + + LD+ DS + + +
Sbjct: 188 VNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLL 247
Query: 502 ----------------PRRLASTSDIEEKENRDSSSLRTSSSYTRRKWEDDLKKNSSVNE 545
P +A T ++E R+ SYT D ++ SVN
Sbjct: 248 LRHGGNPFQANKHGERPVDVAETEELELLLKREVPLSDDDESYT------DSEEAQSVNP 301
Query: 546 GSTYHKSCSFGRRQDDLISSS---VPSTTSTPTVTSAAGLQ----KSLLSSTSTTTKITT 598
S+ ++ +D LI S +PS T P+ + + + +
Sbjct: 302 -SSVDENIDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRK 360
Query: 599 GSSSAGTQSSTSNRLWAED------STEKEKDSVPTAVTIPVAPTVVNAAASTTTLTTTT 652
+ L+A+ + K K P+ V + A ++T+
Sbjct: 361 EQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSC 420
Query: 653 AGTVSSTTEVRERRRSYLTPVRDEES-----ESQRKARSRQARQSRRSTQGVTLTDLQEA 707
+ ++ + ++ Y+ ++ + + + ++++ ++ ++ +G T +
Sbjct: 421 SVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNL 480
Query: 708 EKTIGRSRSTRTREQENEEKEKEEK-----------------------EKQDKE-KQEEK 743
G S +TRE+ N K K EKQ KQE
Sbjct: 481 TVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHT 540
Query: 744 KESETSREDEYK-QKYSRTYDETYQRYRPVSTSSSTTPSSSLST----------MSSSLY 792
K + E Q YD T + P S+S + S S+
Sbjct: 541 KTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAK 600
Query: 793 ASSQLNRP---NSLVGITSAYSRGIT------KENEREGEKREEEKEGE-DKSQPK-SIR 841
+ + P NS + G T K ERE EK ++E EGE +K + K S +
Sbjct: 601 IKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAK 660
Query: 842 ERRRPREKRRSTGVSFWTQD---SDENE-----QEQQSDTEEGSNK--------KETQTD 885
E +R E R FW ++ SDE E E +S T E +K K T+
Sbjct: 661 ELQRSVEFDR----EFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEK 716
Query: 886 SISRYETSSTSAGDRYDSLLGRSGSYSYLEERKPYSSRLEKDDSTDFKKLYEQILAENEK 945
+S+ E + D+ +S +++ K + D ++F L + A E
Sbjct: 717 HVSK-ERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSL--GMSAIEES 773
Query: 946 LKAQLHDTNMELTDLKLQLEKATQRQERFADRSLLEMEKRERRAL--ERRISEMEEELKM 1003
+ L + +++ + ++++ ++ E+ + ++EK ER+ E++I + K
Sbjct: 774 IGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKD 833
Query: 1004 LPDLKADNQRLKDEN 1018
DL ++K+++
Sbjct: 834 KLDLSECVDKIKEKD 848
Score = 40.4 bits (93), Expect = 0.009
Identities = 110/572 (19%), Positives = 216/572 (37%), Gaps = 91/572 (15%)
Query: 275 DILGYLEELQKKQNLL--HSEKRDKKSPLIESTANM---DNNQSQKTFKNKETLIIEPEK 329
D+ ++++++K L H+EK K+ ++TA + D+ + + +++ +PEK
Sbjct: 836 DLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEK 895
Query: 330 NASRIESLEQEKVDEEEEGKKDESSCSSEEDEEDDSESEAETDKT-----KPLASVTNA- 383
ES E+ + E++ K+ ++S S+ ++ + E + E DK K ++TN+
Sbjct: 896 ERHLAESKEKHLM--EKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSK 953
Query: 384 -----NTSSTQAAPVAVTTPTVSSGQATPTSPIKKFPTTATKISPKEEERKDESPATWRL 438
SS A +S + T P+K KE+++KD+
Sbjct: 954 HIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLK-------TPDGKEKDKKDK------- 999
Query: 439 GLRKTGSYGALAEITASKEGQKEKDTAGVT------RSASSPRLSSSLDNKEKEKDSKGT 492
+I KE K KD + A P+ SS +K+ K
Sbjct: 1000 ------------DIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRL 1047
Query: 493 RLAYVAPTIPRRLASTSDIE---------------EKE---NRDSSSLR-TSSSYTRRKW 533
+ T R+ S D+E EKE NR+ L+ T+
Sbjct: 1048 VNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTP 1107
Query: 534 EDDLKKNSSVNEGSTYHKSCSFGRRQDDLISSSVPSTTSTPTVTSAAGLQKSLLSSTSTT 593
+ K + ++ S + + ++ D +S+ S + +T + S +S S
Sbjct: 1108 TESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLG---KSSFVSDNSLN 1164
Query: 594 TKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVPTAVTIPVAPTVVNAAASTTTLTTTTA 653
+ + G S + + + S +DS T VT P P + S L ++ +
Sbjct: 1165 RSPRSENEKPGLSSRSVSMI----SVASSEDSCHTTVTTPRPPVEYD---SDFMLESSES 1217
Query: 654 GTVSSTTEVRERRRSYLTPVRDEESESQRKARSRQARQSRRSTQGVTLTDLQEAEKTIGR 713
S + +S R+ +S + R + +R ST + + +++ + I
Sbjct: 1218 QMSFSQSPFLSIAKSPALHERELDSLADLPERIKPPYANRLSTSHLRSSSVEDVKLIISE 1277
Query: 714 SRSTRTREQENEEKEKEEKEKQDKEKQEEKKE-------SETSREDEYKQKYSRTYDETY 766
R T + + E KQ + EE + +TS + + +S +
Sbjct: 1278 GRPTIEVRRCSMPSVICEHTKQFQTISEESNQGSLLTVPGDTSPSPK-PEVFSNVPERDL 1336
Query: 767 QRYRPVSTSSSTTPSSSLSTMSSSLYASSQLN 798
+ +S +T+P+ + S+S Y S+ N
Sbjct: 1337 SNVSNIHSSFATSPTGA----SNSKYVSADRN 1364
Score = 37.4 bits (85), Expect = 0.073
Identities = 100/554 (18%), Positives = 194/554 (35%), Gaps = 105/554 (18%)
Query: 307 NMDNNQSQKTFKNKETLIIEPEKNASRIESLEQEKVDEEEEGKKDESSCSSEEDEEDDSE 366
NM++ K+K I+ +K+ ++ EE + K ES S E++ D +
Sbjct: 689 NMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLK 748
Query: 367 SEAETDKTKPLASVTNANTSSTQAA----------PVAVTTPTVSSGQATPT--SPIKKF 414
E E T + T+ S+ + + + + + P S IK+
Sbjct: 749 EERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEK 808
Query: 415 PTTATKISPKEEERK---DESPATWRLGL--------RKTGSYGALAEITASKEGQKEKD 463
+ E+E+K + +L L K Y E KEG+K K+
Sbjct: 809 DIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTE-KCHKEGEKSKN 867
Query: 464 TAGVTRSASSPRLSSSLDNK-EKEKDSKGTRLAYVAPTIPRRLASTSDIEEKENRDSSSL 522
TA + ++ + +D K +KEK K LA + + EK+N+ S +
Sbjct: 868 TAAIKKTDDREKSREKMDRKHDKEKPEKERHLAE---------SKEKHLMEKKNKQSDNS 918
Query: 523 RTSSSYTRRKWEDDLKKNSSVNEGSTYHKSCSFGRRQDDLISSSVPSTTSTPTVTSAAGL 582
S S +G K +++ S+ +T++ +
Sbjct: 919 EYSKS----------------EKGKNKEKDRELDKKEKSRDKESI-------NITNSKHI 955
Query: 583 QKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVPTAVTIPVAPTVVNAA 642
Q+ SS K + + + L D EK+K
Sbjct: 956 QEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKD----------------- 998
Query: 643 ASTTTLTTTTAGTVSSTTEVRERRR-------SYLTPVRDEESESQRKARSRQARQSRRS 695
+ER + + L ++ E + + K+ S ++ +R
Sbjct: 999 --------------KDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKS-SPASKDTRPK 1043
Query: 696 TQGVTLTDLQEAEKTIGRSRSTRTREQEN-EEKEKEEKEKQDKEKQEEKKESETSREDEY 754
+ + DL + + R S + E E +K KE+ ++++KE+ + E +D+
Sbjct: 1044 EKRLVNDDLMQT--SFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKE 1101
Query: 755 KQKYSRTYDETYQRYRPVST------SSSTTPSSSLSTMSSSLYASSQLNRPNSLVGITS 808
K K++ T + + R S+ + P ++S S S+ + + S +
Sbjct: 1102 KTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDN 1161
Query: 809 AYSRGITKENEREG 822
+ +R ENE+ G
Sbjct: 1162 SLNRSPRSENEKPG 1175
>gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]
Length = 2062
Score = 103 bits (256), Expect = 1e-21
Identities = 201/1039 (19%), Positives = 400/1039 (38%), Gaps = 134/1039 (12%)
Query: 26 PPVVKRQKTKV--KFDDGAVFL-AACSSGDTDEVLKLLHRGADINYANVDGLTALHQACI 82
P RQK KV + + G L A GD +V +L+ GA++N + G T LH+AC
Sbjct: 168 PSSSSRQKDKVNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACN 227
Query: 83 DDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTP 142
D+ K L+ GA++N + PLH +AS G+ DI + L+ G + N G+ P
Sbjct: 228 VGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERP 287
Query: 143 LDIAEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTA 202
+D+AE E +E LL+ EV D EE Q +N +++ +++ +
Sbjct: 288 VDVAETEELELLLKREVPLSDDDESYTDSEE--------AQSVNPSSVDENIDSETEKDS 339
Query: 203 LHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVN 262
L + +K L A + KD D +E ++D D ++
Sbjct: 340 L-ICESKQILPSKTPLPSALDEYEFKDDD-------------DEEINKMID---DRHILR 382
Query: 263 KVGQTAFDVADEDILGYLEELQKKQNLLHSEKRDKKSPLIESTANMDNNQSQKTFKNKET 322
K + + E + ++ + K+ K S ++ S+ + ++ + K +
Sbjct: 383 KEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTS 442
Query: 323 LIIEPEKNASRIESLEQEKVDEEEEGK-----KDESSCSSEEDEEDDSESEAE------- 370
+ PE + S +++ ++ V E + K K ++ ++E++E E E +
Sbjct: 443 CSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITN 502
Query: 371 ---------TDKTKP----LASVTNANTSSTQAAPVAV-TTPTVSSGQATPTSPIKKFPT 416
++KT+ S + + +S ++ +P S G + S K
Sbjct: 503 LTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEH 562
Query: 417 TATKISPKEEERKDESPATWRLGLRKTGSYGALAEITASKEGQK------------EKDT 464
T T +SP E + P R ++ + + + K +K EK
Sbjct: 563 TKTCLSPGSSEMSLQ-PDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSN 621
Query: 465 AGVTRSASSPRL-SSSLDNKEKEKDSKGTRLAYVAPTIPRRLASTSDIE-EKE---NRDS 519
A + SP +S K+ +K+ K + + + +IE EKE +DS
Sbjct: 622 AKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDS 681
Query: 520 S-SLRTSSSYTRRKWEDDLKKNSSVNE--GSTYHKSCSFGRRQDDLISSSVPSTTSTPTV 576
+ L+ S + R W+++ K+ + + H+S + ++ + +T V
Sbjct: 682 AKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHV 741
Query: 577 TSAAGLQKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVPTAVTIPVAP 636
+ ++ KI S + + + ++ +KDS T++ +
Sbjct: 742 SKERNFKEE-------RDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIE 794
Query: 637 TVVNAAASTTTLTTTTAGTVSSTTEVRERRRSYLTPVRDEESESQRKARSRQARQSRRST 696
+ + ++ + +RS + E+ E + + ++ + +S
Sbjct: 795 ESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSE 854
Query: 697 Q-----GVTLTDLQEAEKTIGRSRSTRTREQENEEKEKEEKEKQDKEKQEEKKESETSRE 751
+ + ++E +K +E E + K+ D+EK EK + + +E
Sbjct: 855 KDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKE 914
Query: 752 DEYKQKYSRTYDETYQRYRPVSTSSSTTPSSSLSTMSSSLYASSQLNRPNSLVGITSAYS 811
K+++ E + + S ++ S S
Sbjct: 915 KPEKERHLAESKEKHLMEKKNKQSDNSEYSKS---------------------------E 947
Query: 812 RGITKENEREGEKREE--EKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQEQ 869
+G KE +RE +K+E+ +KE + + K I+E ++ + E +++
Sbjct: 948 KGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDE 1007
Query: 870 QSDTEEGSNKKETQTDSISRY-ETSSTSAGDRYDSLLGRSGSYSYLEERKPYSSRLEKDD 928
T +G K + D I RY E + +SLL S ++ KP SS KD
Sbjct: 1008 PLKTPDGKEKDKKDKD-IDRYKERDKHKDKIQINSLLKLK---SEADKPKPKSSPASKDT 1063
Query: 929 STDFKKLYEQILAENEKLKAQLHDTNMELTDLKLQ------LEKATQRQ-ERFADRSLLE 981
K+L N+ L + + L DL+++ EK Q++ ER +R+ LE
Sbjct: 1064 RPKEKRLV------NDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLE 1117
Query: 982 MEKRERRALERRISEMEEE 1000
++ +++ + +E + +
Sbjct: 1118 LKIKDKEKTKHTPTESKNK 1136
Score = 40.4 bits (93), Expect = 0.009
Identities = 110/572 (19%), Positives = 216/572 (37%), Gaps = 91/572 (15%)
Query: 275 DILGYLEELQKKQNLL--HSEKRDKKSPLIESTANM---DNNQSQKTFKNKETLIIEPEK 329
D+ ++++++K L H+EK K+ ++TA + D+ + + +++ +PEK
Sbjct: 859 DLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEK 918
Query: 330 NASRIESLEQEKVDEEEEGKKDESSCSSEEDEEDDSESEAETDKT-----KPLASVTNA- 383
ES E+ + E++ K+ ++S S+ ++ + E + E DK K ++TN+
Sbjct: 919 ERHLAESKEKHLM--EKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSK 976
Query: 384 -----NTSSTQAAPVAVTTPTVSSGQATPTSPIKKFPTTATKISPKEEERKDESPATWRL 438
SS A +S + T P+K KE+++KD+
Sbjct: 977 HIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLK-------TPDGKEKDKKDK------- 1022
Query: 439 GLRKTGSYGALAEITASKEGQKEKDTAGVT------RSASSPRLSSSLDNKEKEKDSKGT 492
+I KE K KD + A P+ SS +K+ K
Sbjct: 1023 ------------DIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRL 1070
Query: 493 RLAYVAPTIPRRLASTSDIE---------------EKE---NRDSSSLR-TSSSYTRRKW 533
+ T R+ S D+E EKE NR+ L+ T+
Sbjct: 1071 VNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTP 1130
Query: 534 EDDLKKNSSVNEGSTYHKSCSFGRRQDDLISSSVPSTTSTPTVTSAAGLQKSLLSSTSTT 593
+ K + ++ S + + ++ D +S+ S + +T + S +S S
Sbjct: 1131 TESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLG---KSSFVSDNSLN 1187
Query: 594 TKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVPTAVTIPVAPTVVNAAASTTTLTTTTA 653
+ + G S + + + S +DS T VT P P + S L ++ +
Sbjct: 1188 RSPRSENEKPGLSSRSVSMI----SVASSEDSCHTTVTTPRPPVEYD---SDFMLESSES 1240
Query: 654 GTVSSTTEVRERRRSYLTPVRDEESESQRKARSRQARQSRRSTQGVTLTDLQEAEKTIGR 713
S + +S R+ +S + R + +R ST + + +++ + I
Sbjct: 1241 QMSFSQSPFLSIAKSPALHERELDSLADLPERIKPPYANRLSTSHLRSSSVEDVKLIISE 1300
Query: 714 SRSTRTREQENEEKEKEEKEKQDKEKQEEKKE-------SETSREDEYKQKYSRTYDETY 766
R T + + E KQ + EE + +TS + + +S +
Sbjct: 1301 GRPTIEVRRCSMPSVICEHTKQFQTISEESNQGSLLTVPGDTSPSPK-PEVFSNVPERDL 1359
Query: 767 QRYRPVSTSSSTTPSSSLSTMSSSLYASSQLN 798
+ +S +T+P+ + S+S Y S+ N
Sbjct: 1360 SNVSNIHSSFATSPTGA----SNSKYVSADRN 1387
Score = 37.4 bits (85), Expect = 0.073
Identities = 100/554 (18%), Positives = 194/554 (35%), Gaps = 105/554 (18%)
Query: 307 NMDNNQSQKTFKNKETLIIEPEKNASRIESLEQEKVDEEEEGKKDESSCSSEEDEEDDSE 366
NM++ K+K I+ +K+ ++ EE + K ES S E++ D +
Sbjct: 712 NMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLK 771
Query: 367 SEAETDKTKPLASVTNANTSSTQAA----------PVAVTTPTVSSGQATPT--SPIKKF 414
E E T + T+ S+ + + + + + P S IK+
Sbjct: 772 EERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEK 831
Query: 415 PTTATKISPKEEERK---DESPATWRLGL--------RKTGSYGALAEITASKEGQKEKD 463
+ E+E+K + +L L K Y E KEG+K K+
Sbjct: 832 DIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTE-KCHKEGEKSKN 890
Query: 464 TAGVTRSASSPRLSSSLDNK-EKEKDSKGTRLAYVAPTIPRRLASTSDIEEKENRDSSSL 522
TA + ++ + +D K +KEK K LA + + EK+N+ S +
Sbjct: 891 TAAIKKTDDREKSREKMDRKHDKEKPEKERHLAE---------SKEKHLMEKKNKQSDNS 941
Query: 523 RTSSSYTRRKWEDDLKKNSSVNEGSTYHKSCSFGRRQDDLISSSVPSTTSTPTVTSAAGL 582
S S +G K +++ S+ +T++ +
Sbjct: 942 EYSKS----------------EKGKNKEKDRELDKKEKSRDKESI-------NITNSKHI 978
Query: 583 QKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVPTAVTIPVAPTVVNAA 642
Q+ SS K + + + L D EK+K
Sbjct: 979 QEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKD----------------- 1021
Query: 643 ASTTTLTTTTAGTVSSTTEVRERRR-------SYLTPVRDEESESQRKARSRQARQSRRS 695
+ER + + L ++ E + + K+ S ++ +R
Sbjct: 1022 --------------KDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKS-SPASKDTRPK 1066
Query: 696 TQGVTLTDLQEAEKTIGRSRSTRTREQEN-EEKEKEEKEKQDKEKQEEKKESETSREDEY 754
+ + DL + + R S + E E +K KE+ ++++KE+ + E +D+
Sbjct: 1067 EKRLVNDDLMQT--SFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKE 1124
Query: 755 KQKYSRTYDETYQRYRPVST------SSSTTPSSSLSTMSSSLYASSQLNRPNSLVGITS 808
K K++ T + + R S+ + P ++S S S+ + + S +
Sbjct: 1125 KTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDN 1184
Query: 809 AYSRGITKENEREG 822
+ +R ENE+ G
Sbjct: 1185 SLNRSPRSENEKPG 1198
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 103 bits (256), Expect = 1e-21
Identities = 70/231 (30%), Positives = 114/231 (49%), Gaps = 27/231 (11%)
Query: 42 AVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQ 101
A S G V L+ RGA++++ + DG+T L A + +VD+V L+E GA+++
Sbjct: 717 AALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDH 776
Query: 102 PDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNR 161
DN G PL AAAS G+ + L+ GA V +++SEG T L IA + E+++ ++R
Sbjct: 777 TDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDR 836
Query: 162 QGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQA 221
L+ H +D +G T LH+AA +G+ + + LI+
Sbjct: 837 ----------------------GLDENHRDD-----AGWTPLHMAAFEGHRLICEALIEQ 869
Query: 222 GYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVA 272
G N D DG P A+ G + +IL++N +++ G+ A VA
Sbjct: 870 GARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVA 920
Score = 94.7 bits (234), Expect = 4e-19
Identities = 75/245 (30%), Positives = 114/245 (46%), Gaps = 22/245 (8%)
Query: 40 DGAVFLA-ACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGAN 98
+G LA A SG D V L+ RGAD+ + G T L A + +V L+ GAN
Sbjct: 544 NGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGAN 603
Query: 99 INQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNE 158
IN D +GW L +AA G+ ++ L+ G V +++ T L A E+++ N
Sbjct: 604 INHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLN- 662
Query: 159 VNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHA-----------KSGGTALHVA- 206
+ + G ++ A E ++ A GH V H G TAL VA
Sbjct: 663 LLQHGAEVNKADNEGRTALIAAAYM----GHREIVEHLLDHGAEVNHEDVDGRTALSVAA 718
Query: 207 ----AAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVN 262
A+KG+ V+ LLI G +V+ D DG TPL AA+ G + +L++ D++ +
Sbjct: 719 LCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTD 778
Query: 263 KVGQT 267
G+T
Sbjct: 779 NNGRT 783
Score = 94.7 bits (234), Expect = 4e-19
Identities = 76/286 (26%), Positives = 124/286 (43%), Gaps = 54/286 (18%)
Query: 39 DDGAVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGAN 98
D +A G T+ V LL+ G ++ A+ D TAL A + D+V L+++GA
Sbjct: 610 DGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAE 669
Query: 99 INQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIA-----EEEAMEE 153
+N+ DNEG L AAA G+ +I E L+ GA V + +G T L +A +
Sbjct: 670 VNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHAS 729
Query: 154 LLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHIN----------DVRHAKSGG--- 200
++ ++R G +++ K+ +L A + GH++ DV H + G
Sbjct: 730 VVSLLIDR-GAEVDHCDKDGMTPLLVAAYE----GHVDVVDLLLEGGADVDHTDNNGRTP 784
Query: 201 -------------------------------TALHVAAAKGYTEVLKLLIQAGYDVNIKD 229
T L +A+A+G EV++ L+ G D N +D
Sbjct: 785 LLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRD 844
Query: 230 YDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVADED 275
GWTPLH AA G C L++ ++ G+ F +A ++
Sbjct: 845 DAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQE 890
Score = 91.3 bits (225), Expect = 4e-18
Identities = 108/446 (24%), Positives = 190/446 (42%), Gaps = 57/446 (12%)
Query: 39 DDGAV-FLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGA 97
+DG + F+ A G D V LL ++I+ DG AL A ++ + D+V+ L +GA
Sbjct: 878 NDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGA 937
Query: 98 NINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQN 157
++N D +G L+ A L +AE+ + GA+V A ++EG T L ++ + E++Q
Sbjct: 938 DVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQV 997
Query: 158 EVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVR-----------HAKSGGTALHVA 206
+ D+ AA E+ + A Q GH+ V+ G TAL +A
Sbjct: 998 LI-AYHADVNAADNEKRSALQSAAWQ----GHVKVVQLLIEHGAVVDHTCNQGATALCIA 1052
Query: 207 AAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQ 266
A +G+ +V+++L++ G D N D G T + AA G + ++L K G
Sbjct: 1053 AQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLL----------EKYGA 1102
Query: 267 TAFDVADEDILGYLEELQKKQNLLHSEKRDKKSPLIESTANMDNNQSQKTFKNKETLIIE 326
++ + + +E+ + + KS ST D S + N T
Sbjct: 1103 SSLNGCSPSPVHTMEQKPLQSLSSKVQSLTIKSNSSGSTGGGDMQPSLRGLPNGPT---- 1158
Query: 327 PEKNASRIESLEQEKVDEEEEGKKDESSCSSEEDEEDDSESEAETDKTKPLASVTNAN-- 384
+A S + + ++ +S S ++ + S T +T P+ S N +
Sbjct: 1159 ---HAFSSPSESPDSTVDRQKSSLSNNSLKSSKNSSLRTTSSTATAQTVPIDSFHNLSFT 1215
Query: 385 ---------TSSTQAAPVAVTTPTVSSGQATPTSPIKKFPTTATKISPKEEER----KDE 431
S ++ + V+ ++ T S GQ + SP +F + K S K + K E
Sbjct: 1216 EQIQQHSLPRSRSRQSIVSPSSTTQSLGQ-SHNSPSSEFEWSQVKPSLKSTKASKGGKSE 1274
Query: 432 SPATWRLGLRKTGSYGALAEITASKE 457
+ A K+GS G A+ + S +
Sbjct: 1275 NSA-------KSGSAGKKAKQSNSSQ 1293
Score = 85.1 bits (209), Expect = 3e-16
Identities = 72/235 (30%), Positives = 110/235 (46%), Gaps = 21/235 (8%)
Query: 54 DEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAA 113
D + LL GA +N + +G T L A ++D+V LV GA++ D G PL A
Sbjct: 526 DSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLA 585
Query: 114 ASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEE 173
A G+ + LIG GA++ + +G T L A E++ + + GV ++ A +
Sbjct: 586 ARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVV-SALLYAGVKVDCA-DAD 643
Query: 174 ERIMLRDARQWLNSGH----INDVRHA-------KSGGTALHVAAAKGYTEVLKLLIQAG 222
R LR A W GH +N ++H G TAL AA G+ E+++ L+ G
Sbjct: 644 SRTALR-AAAW--GGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHG 700
Query: 223 YDVNIKDYDGWTPLHAA-----AHWGKEEACRILVDNLCDMEMVNKVGQTAFDVA 272
+VN +D DG T L A A G +L+D +++ +K G T VA
Sbjct: 701 AEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVA 755
Score = 85.1 bits (209), Expect = 3e-16
Identities = 65/250 (26%), Positives = 123/250 (49%), Gaps = 12/250 (4%)
Query: 43 VFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQP 102
V A + G+ + V LL RG D N+ + G T LH A + + + + L+E GA N+
Sbjct: 817 VLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEI 876
Query: 103 DNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQ 162
DN+G IP A+ G+ D + L+ +++ +G L +A E ++++ +
Sbjct: 877 DNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVE-LLFSH 935
Query: 163 GVDIEAARKEEERIM--------LRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEV 214
G D+ + + L A +L +G + A+ G TALHV+ +G+ E+
Sbjct: 936 GADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAE-GRTALHVSCWQGHMEM 994
Query: 215 LKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVADE 274
+++LI DVN D + + L +AA G + ++L+++ ++ G TA +A +
Sbjct: 995 VQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQ 1054
Query: 275 DILGYLEELQ 284
+ G+++ +Q
Sbjct: 1055 E--GHIDVVQ 1062
Score = 30.4 bits (67), Expect = 9.0
Identities = 23/84 (27%), Positives = 39/84 (46%), Gaps = 4/84 (4%)
Query: 189 HINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEAC 248
H+N ++ T+ V A + ++ L+ G VN D +G T L AA+ G +
Sbjct: 506 HVN----SEDDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVV 561
Query: 249 RILVDNLCDMEMVNKVGQTAFDVA 272
+LV D+E+ + G T +A
Sbjct: 562 NLLVSRGADLEIEDAHGHTPLTLA 585
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 102 bits (255), Expect = 1e-21
Identities = 77/239 (32%), Positives = 120/239 (50%), Gaps = 17/239 (7%)
Query: 46 AACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNE 105
AA S+G + V LL+ G +I+ NV G TALH AC + +V L++ GAN+NQP+N
Sbjct: 187 AAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNN 246
Query: 106 GWIPLH-AAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEA----MEELLQNEVN 160
G+ PLH AAAS E L+ GA V + +G +PL + + L+QN
Sbjct: 247 GFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQN--- 303
Query: 161 RQGVDIEAARKEEERIMLRDARQ----WLNSGHINDVRHAKSGGTA---LHVAAAKGYTE 213
G +I+ K+ + AR +N+ + AK G + LH+AA +++
Sbjct: 304 --GGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSD 361
Query: 214 VLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVA 272
+ L+ +G++++ D G T LHAAA G E ++L + D +K G+T A
Sbjct: 362 CCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYA 420
Score = 97.8 bits (242), Expect = 5e-20
Identities = 69/227 (30%), Positives = 110/227 (48%), Gaps = 28/227 (12%)
Query: 47 ACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEG 106
A +G + V LL +GA+IN + ALH A ++D+V L+ +GA + D +G
Sbjct: 122 AALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKG 181
Query: 107 WIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDI 166
+ PLHAAAS G +++ + L+ G + +N G+T L IA + ++ NE+ G ++
Sbjct: 182 YTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVV-NELIDYGANV 240
Query: 167 EAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEV-LKLLIQAGYDV 225
+G T LH AAA + + L+LL+ G DV
Sbjct: 241 NQPN--------------------------NNGFTPLHFAAASTHGALCLELLVNNGADV 274
Query: 226 NIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVA 272
NI+ DG +PLH A G+ + L+ N +++ V+K G T VA
Sbjct: 275 NIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVA 321
Score = 94.0 bits (232), Expect = 7e-19
Identities = 70/232 (30%), Positives = 116/232 (50%), Gaps = 9/232 (3%)
Query: 47 ACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEG 106
A + +D KLL G +I+ + G T LH A NV+ +K L +GA+ ++ D G
Sbjct: 354 AALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCG 413
Query: 107 WIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAME--ELLQNEVNRQGV 164
PLH AA+ + E L+ GA+V + G T L A M+ + + +
Sbjct: 414 RTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSE 473
Query: 165 DIEAAR--KEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAG 222
++E AR KE+E + ++L N K G ++H AAA G+ + L+LL++
Sbjct: 474 ELERARELKEKEATL---CLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERT 530
Query: 223 YDVNIKDYDGWT--PLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVA 272
+ G T PLH AA+ G +A +L+ +L D+++ ++ G+TA D+A
Sbjct: 531 NSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLA 582
Score = 86.7 bits (213), Expect = 1e-16
Identities = 63/220 (28%), Positives = 103/220 (46%), Gaps = 6/220 (2%)
Query: 59 LLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGY 118
L+H+ D+N + + T LH A + ++++ L+ +GA +N DN PLH A +
Sbjct: 2 LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRS 61
Query: 119 LDIAEFLIGQGAHVGAVNSEGDTPLDIA---EEEAMEELLQNEVNRQGVDIEAARKEEER 175
+ + LI A V A + TPL +A + E++ ++ V R
Sbjct: 62 EEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHH 121
Query: 176 IMLRDARQWLN---SGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDG 232
L + +N + N K ALH AA G+ +V+ LLI G +V KD G
Sbjct: 122 AALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKG 181
Query: 233 WTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVA 272
+TPLHAAA G+ + L++ +++ +N G TA +A
Sbjct: 182 YTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIA 221
Score = 75.9 bits (185), Expect = 2e-13
Identities = 62/233 (26%), Positives = 110/233 (47%), Gaps = 17/233 (7%)
Query: 47 ACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEG 106
A +S + V L+ AD+N + + T LH A + V + ++ +++N D G
Sbjct: 56 AVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGG 115
Query: 107 WIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDI 166
LH AA G++++ L+ +GA++ A + + L A +++ +N G ++
Sbjct: 116 RTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLIN-HGAEV 174
Query: 167 EAARKEEERIMLRDARQWLNSGHINDVRHAKS-----------GGTALHVAAAKGYTEVL 215
K+ + A ++G IN V+H + G TALH+A G V+
Sbjct: 175 TCKDKKGYTPLHAAA----SNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVV 230
Query: 216 KLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEAC-RILVDNLCDMEMVNKVGQT 267
LI G +VN + +G+TPLH AA C +LV+N D+ + +K G++
Sbjct: 231 NELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKS 283
Score = 72.0 bits (175), Expect = 3e-12
Identities = 66/223 (29%), Positives = 99/223 (44%), Gaps = 13/223 (5%)
Query: 47 ACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDN-E 105
A +G + LL D++ + G TAL A + + V+ L+ GA+I DN
Sbjct: 549 AAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVT 608
Query: 106 GWIPLHAAASCGYLDIAEFLIGQGAHVGAV---NSEGDTPLDIA----EEEAMEELLQNE 158
PLHA+ G+ L+ + AV +++G TPL +A +A+ LL+ E
Sbjct: 609 KRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKE 668
Query: 159 VNRQGVDIEAARKEEERIML--RDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLK 216
N VDI IM + Q L ++ + G T LH AAA+G+ L
Sbjct: 669 ANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLS 728
Query: 217 LLIQAGY---DVNIKDYDGWTPLHAAAHWGKEEACRILVDNLC 256
L+Q D KD G+TPLH A + G E +L++ C
Sbjct: 729 ELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKC 771
Score = 67.4 bits (163), Expect = 7e-11
Identities = 69/265 (26%), Positives = 117/265 (44%), Gaps = 48/265 (18%)
Query: 45 LAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDN 104
+ A + G D V LL + A+++ ++ G TALH+ + + + V+ L+E +I D+
Sbjct: 650 MLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDS 709
Query: 105 EGWIPLHAAASCGYLDIAEFLIGQGAHVGAV---NSEGDTPLDIA----EEEAMEELLQN 157
G PLH AA+ G+ L+ +++G TPL A E +E LL+
Sbjct: 710 RGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQ 769
Query: 158 EVNRQGV----------------------------DIEAARKEEERIMLRDAR------- 182
+ R+ + I + R ++ R LR A
Sbjct: 770 KCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVEC 829
Query: 183 -QWL--NSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGY-DVNIKDYDGWTPLHA 238
Q L +S +N V + SG TAL +AA G + +L+ + D+ +KD D TPLH
Sbjct: 830 LQLLLRHSAPVNAVDN--SGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHL 887
Query: 239 AAHWGKEEACRILVDNLCDMEMVNK 263
A G E+ +++D + D ++N+
Sbjct: 888 ACSKGHEKCALLILDKIQDESLINE 912
Score = 52.4 bits (124), Expect = 2e-06
Identities = 72/288 (25%), Positives = 116/288 (40%), Gaps = 75/288 (26%)
Query: 59 LLHRGADINYANVDGLTALHQACIDD-------------NVD---------------MVK 90
L+ GA++N + G TALH A D N + ++
Sbjct: 432 LVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLE 491
Query: 91 FLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDT--PLDIA-- 146
FL++N AN + D EG+ +H AA+ G+ E L+ + + G T PL +A
Sbjct: 492 FLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAY 551
Query: 147 --EEEAMEELLQN--------EVNRQGVDIEAARKEEE----------RIMLRD---ARQ 183
+A+E LLQ+ E R +D+ A + E I ++D R
Sbjct: 552 NGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRT 611
Query: 184 WLNSGHIN-------------------DVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYD 224
L++ IN DV+ AK G T L +A A G+ + + LL++ +
Sbjct: 612 PLHASVINGHTLCLRLLLEIADNPEAVDVKDAK-GQTPLMLAVAYGHIDAVSLLLEKEAN 670
Query: 225 VNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVA 272
V+ D G T LH G EE ++L++ + + G+T A
Sbjct: 671 VDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYA 718
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 102 bits (255), Expect = 1e-21
Identities = 99/368 (26%), Positives = 163/368 (44%), Gaps = 38/368 (10%)
Query: 59 LLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGY 118
LL R A N A +GLT LH A +N+D+VK L+ G + + P G+ PLH AA
Sbjct: 588 LLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQ 647
Query: 119 LDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQ---------NEVNRQGVDIEAA 169
+++A L+ G A + +G TPL +A +E E++ N N+ G+
Sbjct: 648 VEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHL 707
Query: 170 RKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKD 229
+E + + D + G + D + G T LHVA+ G +++K L+Q DVN K
Sbjct: 708 VAQEGHVPVADV--LIKHGVMVDAT-TRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKT 764
Query: 230 YDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVADEDILGYLE-------E 282
G++PLH AA G + +L+ N V+ G T +A LGY+
Sbjct: 765 KLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKR--LGYISVTDVLKVV 822
Query: 283 LQKKQNLLHSEKRDKKSP-LIESTANM--DNNQSQKTFKNKETLIIEPEKNASRIESLEQ 339
+ +L S+K P ++ ++ D + T +E + + E+ SR E+
Sbjct: 823 TDETSFVLVSDKHRMSFPETVDEILDVSEDEGTAHITIMGEELISFKAERRDSRDVDEEK 882
Query: 340 E------KVDEEEEGKK-DESSCSSEE------DEEDDSESEAETDKTKPLASVTNANTS 386
E K+D+ E C+ E +E++ + E + D P + T + +
Sbjct: 883 ELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSDN 942
Query: 387 -STQAAPV 393
S A+PV
Sbjct: 943 ISPVASPV 950
Score = 102 bits (253), Expect = 2e-21
Identities = 79/265 (29%), Positives = 117/265 (44%), Gaps = 37/265 (13%)
Query: 35 KVKFDDGAVFLAACSSGDTDEVLKLLHRGADINYANVDGL-------------------- 74
K K D FL A SG+ D+ L L G DIN N +GL
Sbjct: 40 KKKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLH 99
Query: 75 -------------TALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDI 121
TALH A + ++V+ LV GAN+N +G+ PL+ AA +L++
Sbjct: 100 KEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEV 159
Query: 122 AEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVN---RQGVDIEAARKEEERIML 178
+FL+ GA+ +G TPL +A ++ E ++ + +N + V + A
Sbjct: 160 VKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDT 219
Query: 179 RDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHA 238
R A L + DV +K+G T LH+AA V +LL+ G VN +G TPLH
Sbjct: 220 RTAAVLLQNDPNPDVL-SKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHI 278
Query: 239 AAHWGKEEACRILVDNLCDMEMVNK 263
A+ G R+L+D +E K
Sbjct: 279 ASRRGNVIMVRLLLDRGAQIETKTK 303
Score = 94.0 bits (232), Expect = 7e-19
Identities = 73/258 (28%), Positives = 125/258 (48%), Gaps = 23/258 (8%)
Query: 59 LLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGY 118
LL+RGA +N+ +G+T LH A NV MV+ L++ GA I + PLH AA G+
Sbjct: 258 LLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGH 317
Query: 119 LDIAEFLIGQGAHVGAVNSEGDTPLDIAEE----EAMEELLQNEVNRQGVDIE------- 167
+ I+E L+ GA + A G +P+ +A + + + LLQ + + ++
Sbjct: 318 VRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHV 377
Query: 168 AARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNI 227
AA R+ A+ L+ G + R A +G T LH+A K + V++LL++ G ++
Sbjct: 378 AAHCGHHRV----AKVLLDKGAKPNSR-ALNGFTPLHIACKKNHVRVMELLLKTGASIDA 432
Query: 228 KDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVA----DEDILGYLEEL 283
G TPLH A+ G + L+ + N +T +A ++ YL +
Sbjct: 433 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQN 492
Query: 284 QKKQNLLHSEKRDKKSPL 301
+ K N ++ +D ++PL
Sbjct: 493 KAKVN---AKAKDDQTPL 507
Score = 93.6 bits (231), Expect = 9e-19
Identities = 70/244 (28%), Positives = 112/244 (45%), Gaps = 14/244 (5%)
Query: 39 DDGAVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGAN 98
DD A G T+ V LL A+ N A G T LH A + +V+ V L+E A+
Sbjct: 502 DDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS 561
Query: 99 INQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNE 158
+G+ PLH AA G + +AE L+ + AH A G TPL +A ++++
Sbjct: 562 QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLL 621
Query: 159 VNRQG----------VDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAA 208
+ R G + A K+ + + R Q+ S + V+ G T LH+AA
Sbjct: 622 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQ----GVTPLHLAAQ 677
Query: 209 KGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTA 268
+G+ E++ LL+ + N+ + G TPLH A G +L+ + ++ ++G T
Sbjct: 678 EGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTP 737
Query: 269 FDVA 272
VA
Sbjct: 738 LHVA 741
Score = 89.0 bits (219), Expect = 2e-17
Identities = 71/245 (28%), Positives = 107/245 (43%), Gaps = 7/245 (2%)
Query: 35 KVKFDDGAVFLAACSSGD-TDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLV 93
+ K +G + + GD D V LL A+I+ +D LT LH A + + K L+
Sbjct: 332 QAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL 391
Query: 94 ENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEE 153
+ GA N G+ PLH A ++ + E L+ GA + AV G TPL +A
Sbjct: 392 DKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLP 451
Query: 154 LLQNEVNR------QGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAA 207
+++N + R V +E R + ++L AK T LH AA
Sbjct: 452 IVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAA 511
Query: 208 AKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQT 267
G+T ++KLL++ + N+ G TPLH AA G E L++ + K G T
Sbjct: 512 RIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFT 571
Query: 268 AFDVA 272
VA
Sbjct: 572 PLHVA 576
Score = 88.2 bits (217), Expect = 4e-17
Identities = 82/287 (28%), Positives = 125/287 (43%), Gaps = 42/287 (14%)
Query: 56 VLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAAS 115
V LL RGA N +NV T LH A + ++ K+L++N A +N + PLH AA
Sbjct: 453 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 512
Query: 116 CGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEE----LLQNEVNRQGVDIE---- 167
G+ ++ + L+ A+ + G TPL IA E E LL+ E ++ + +
Sbjct: 513 IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTP 572
Query: 168 ---AAR----KEEERIMLRDA------RQWLNSGHINDVRH------------------- 195
AA+ + E ++ RDA + L H+ V H
Sbjct: 573 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHV-AVHHNNLDIVKLLLPRGGSPHSP 631
Query: 196 AKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNL 255
A +G T LH+AA + EV + L+Q G N + G TPLH AA G E +L+
Sbjct: 632 AWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQ 691
Query: 256 CDMEMVNKVGQTAFD-VADEDILGYLEELQKKQNLLHSEKRDKKSPL 301
+ + NK G T VA E + + L K ++ + R +PL
Sbjct: 692 ANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPL 738
Score = 82.8 bits (203), Expect = 2e-15
Identities = 81/286 (28%), Positives = 116/286 (40%), Gaps = 56/286 (19%)
Query: 47 ACSSGDTDEVLKLLHRGADINYANVD---------------------------------G 73
A G+ V LL RGA I D G
Sbjct: 279 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 338
Query: 74 LTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVG 133
L+ +H A D++D V+ L++ A I+ + PLH AA CG+ +A+ L+ +GA
Sbjct: 339 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 398
Query: 134 AVNSEGDTPLDIA----EEEAMEELLQNEVNRQGVDIEAARKEEERIM--------LRDA 181
+ G TPL IA ME LL + G I+A + + L
Sbjct: 399 SRALNGFTPLHIACKKNHVRVMELLL-----KTGASIDAVTESGLTPLHVASFMGHLPIV 453
Query: 182 RQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAH 241
+ L G +V + K T LH+AA G+TEV K L+Q VN K D TPLH AA
Sbjct: 454 KNLLQRGASPNVSNVKV-ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 512
Query: 242 WGKEEACRILVDNLCDMEMVNKVGQTAFDVAD-----EDILGYLEE 282
G ++L++N + + G T +A E +L LE+
Sbjct: 513 IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEK 558
Score = 80.5 bits (197), Expect = 8e-15
Identities = 63/218 (28%), Positives = 95/218 (43%), Gaps = 18/218 (8%)
Query: 47 ACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEG 106
AC + LL GA I+ GLT LH A ++ +VK L++ GA+ N + +
Sbjct: 411 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 470
Query: 107 WIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLD----IAEEEAMEELLQNEVN-- 160
PLH AA G+ ++A++L+ A V A + TPL I ++ LL+N N
Sbjct: 471 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 530
Query: 161 ------RQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEV 214
+ I A E ++ L + K G T LHVAA G V
Sbjct: 531 LATTAGHTPLHIAAREGHVETVLA------LLEKEASQACMTKKGFTPLHVAAKYGKVRV 584
Query: 215 LKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILV 252
+LL++ N +G TPLH A H + ++L+
Sbjct: 585 AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL 622
Score = 70.9 bits (172), Expect = 6e-12
Identities = 69/261 (26%), Positives = 109/261 (41%), Gaps = 25/261 (9%)
Query: 34 TKVKFDDGAVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLV 93
TK K A+ +AA + DT LL + + + G T LH A +N+++ + L+
Sbjct: 201 TKGKVRLPALHIAA-RNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLL 259
Query: 94 ENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEA--- 150
GA++N G PLH A+ G + + L+ +GA + + TPL A
Sbjct: 260 NRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVR 319
Query: 151 MEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGG---------- 200
+ E+L + G I+A K L H++ VR
Sbjct: 320 ISEILLD----HGAPIQAKTKNG----LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH 371
Query: 201 -TALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDME 259
T LHVAA G+ V K+L+ G N + +G+TPLH A +L+ ++
Sbjct: 372 LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 431
Query: 260 MVNKVGQTAFDVADEDILGYL 280
V + G T VA +G+L
Sbjct: 432 AVTESGLTPLHVA--SFMGHL 450
Score = 57.8 bits (138), Expect = 5e-08
Identities = 40/134 (29%), Positives = 57/134 (42%), Gaps = 33/134 (24%)
Query: 47 ACSSGDTDEVLKLLHRGADINYANVDGLTALHQACID----------------------- 83
A G + V LL + A+ N N GLT LH +
Sbjct: 675 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 734
Query: 84 ----------DNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVG 133
N+ +VKFL+++ A++N G+ PLH AA G+ DI L+ GA
Sbjct: 735 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 794
Query: 134 AVNSEGDTPLDIAE 147
V+S+G TPL IA+
Sbjct: 795 EVSSDGTTPLAIAK 808
Score = 50.4 bits (119), Expect = 8e-06
Identities = 36/129 (27%), Positives = 59/129 (45%), Gaps = 17/129 (13%)
Query: 51 GDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPL 110
G+ V LL AD+N G + LHQA + D+V L++NGA+ N+ ++G PL
Sbjct: 745 GNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPL 804
Query: 111 HAAASCGYLDIAE----------FLIGQGAHVGAVNSEGDTPLDIAEEEAM-------EE 153
A GY+ + + F++ H + D LD++E+E EE
Sbjct: 805 AIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGTAHITIMGEE 864
Query: 154 LLQNEVNRQ 162
L+ + R+
Sbjct: 865 LISFKAERR 873
Score = 33.9 bits (76), Expect = 0.81
Identities = 37/160 (23%), Positives = 73/160 (45%), Gaps = 14/160 (8%)
Query: 144 DIAEEEAMEELLQNEVNRQGVDIEAARKEEERI---MLRDARQWLNSGHINDVRHA---- 196
DI + E+ + E NR+ + RK++ LR AR ++ +R+
Sbjct: 13 DIEAQALQEQKEKEESNRKRRNRSRDRKKKADAATSFLRAARSGNLDKALDHLRNGVDIN 72
Query: 197 ---KSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVD 253
++G LH+A+ +G+ +++ L+ + G T LH AA G++E R LV+
Sbjct: 73 TCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVN 132
Query: 254 NLCDMEMVNKVGQTAFDVADE----DILGYLEELQKKQNL 289
++ ++ G T +A + +++ +L E QN+
Sbjct: 133 YGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 172
>gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo
sapiens]
Length = 226
Score = 101 bits (252), Expect = 3e-21
Identities = 67/201 (33%), Positives = 97/201 (48%), Gaps = 27/201 (13%)
Query: 72 DGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAH 131
D TALH AC + ++V+FL++ G +N D+ GW PLH AAS G +I + L+G+GA
Sbjct: 39 DSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQ 98
Query: 132 VGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHIN 191
V AVN G TPL A + E+ +ML + G N
Sbjct: 99 VNAVNQNGCTPLHYAASKNRHEIA--------------------VMLLE-------GGAN 131
Query: 192 DVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRIL 251
TA+H AAAKG +++ +L+ NI+D +G TPLH A + E ++L
Sbjct: 132 PDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLL 191
Query: 252 VDNLCDMEMVNKVGQTAFDVA 272
V + + NK +T VA
Sbjct: 192 VSQGASIYIENKEEKTPLQVA 212
Score = 65.9 bits (159), Expect = 2e-10
Identities = 48/140 (34%), Positives = 72/140 (51%), Gaps = 4/140 (2%)
Query: 37 KFDDGAVFLAACSSGDTDEVLK-LLHRGADINYANVDGLTALHQACIDDNVDMVKFLVEN 95
K D G L +S DE++K LL +GA +N N +G T LH A + ++ L+E
Sbjct: 69 KDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEG 128
Query: 96 GANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIA-EEEAMEEL 154
GAN + D+ +H AA+ G L + L+ A ++EG+TPL +A +EE +EE
Sbjct: 129 GANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEE- 187
Query: 155 LQNEVNRQGVDIEAARKEEE 174
+ QG I KEE+
Sbjct: 188 -AKLLVSQGASIYIENKEEK 206
Score = 62.0 bits (149), Expect = 3e-09
Identities = 62/210 (29%), Positives = 87/210 (41%), Gaps = 27/210 (12%)
Query: 30 KRQKTKVKFDDGAVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMV 89
K T+ D ACS+G T+ V LL G +N + G + LH A ++V
Sbjct: 30 KSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIV 89
Query: 90 KFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEE 149
K L+ GA +N + G PLH AAS +IA L+ GA+ A D E
Sbjct: 90 KALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDA--------KDHYEAT 141
Query: 150 AMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAK 209
AM AA K + M+ + S +I D G T LH+A +
Sbjct: 142 AMH--------------RAAAKGNLK-MIHILLYYKASTNIQDT----EGNTPLHLACDE 182
Query: 210 GYTEVLKLLIQAGYDVNIKDYDGWTPLHAA 239
E KLL+ G + I++ + TPL A
Sbjct: 183 ERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
Score = 59.3 bits (142), Expect = 2e-08
Identities = 49/200 (24%), Positives = 88/200 (44%), Gaps = 28/200 (14%)
Query: 103 DNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQ 162
D + LH A S G+ +I EFL+ G V + G +PL IA +E+++ + +
Sbjct: 37 DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGK- 95
Query: 163 GVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAG 222
G + A + +G T LH AA+K E+ +L++ G
Sbjct: 96 GAQVNAVNQ--------------------------NGCTPLHYAASKNRHEIAVMLLEGG 129
Query: 223 YDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVA-DEDILGYLE 281
+ + KD+ T +H AA G + IL+ + + G T +A DE+ + +
Sbjct: 130 ANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAK 189
Query: 282 ELQKKQNLLHSEKRDKKSPL 301
L + ++ E +++K+PL
Sbjct: 190 LLVSQGASIYIENKEEKTPL 209
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 101 bits (252), Expect = 3e-21
Identities = 82/318 (25%), Positives = 144/318 (45%), Gaps = 36/318 (11%)
Query: 59 LLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGY 118
LL R A N A +GLT LH A +N+D+VK L+ G + + P G+ PLH AA
Sbjct: 555 LLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQ 614
Query: 119 LDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERIML 178
+++A L+ G A + +G TPL +A +E E++ +++Q
Sbjct: 615 VEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA--------------- 659
Query: 179 RDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHA 238
+G++ + KSG T LH+ A +G+ V +LI+ G V+ G+TPLH
Sbjct: 660 --------NGNLGN----KSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHV 707
Query: 239 AAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVADE----DILGYLEELQKKQNLLHSEK 294
A+H+G + + L+ + D+ K+G + A + DI+ L + N + S
Sbjct: 708 ASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSS-- 765
Query: 295 RDKKSPL--IESTANMDNNQSQKTFKNKETLIIEPEKNASRIESLEQEKVDEEEEGKKDE 352
D +PL + + K ++ + ++ +K+ E +D E+ ++
Sbjct: 766 -DGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEEL 824
Query: 353 SSCSSEEDEEDDSESEAE 370
S +E + D + E E
Sbjct: 825 ISFKAERRDSRDVDEEKE 842
Score = 99.8 bits (247), Expect = 1e-20
Identities = 77/261 (29%), Positives = 115/261 (44%), Gaps = 37/261 (14%)
Query: 39 DDGAVFLAACSSGDTDEVLKLLHRGADINYANVDGL------------------------ 74
D FL A SG+ D+ L L G DIN N +GL
Sbjct: 11 DAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEII 70
Query: 75 ---------TALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFL 125
TALH A + ++V+ LV GAN+N +G+ PL+ AA +L++ +FL
Sbjct: 71 LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130
Query: 126 IGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVN---RQGVDIEAARKEEERIMLRDAR 182
+ GA+ +G TPL +A ++ E ++ + +N + V + A R A
Sbjct: 131 LENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAA 190
Query: 183 QWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHW 242
L + DV +K+G T LH+AA V +LL+ G VN +G TPLH A+
Sbjct: 191 VLLQNDPNPDVL-SKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRR 249
Query: 243 GKEEACRILVDNLCDMEMVNK 263
G R+L+D +E K
Sbjct: 250 GNVIMVRLLLDRGAQIETKTK 270
Score = 94.0 bits (232), Expect = 7e-19
Identities = 73/258 (28%), Positives = 125/258 (48%), Gaps = 23/258 (8%)
Query: 59 LLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGY 118
LL+RGA +N+ +G+T LH A NV MV+ L++ GA I + PLH AA G+
Sbjct: 225 LLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGH 284
Query: 119 LDIAEFLIGQGAHVGAVNSEGDTPLDIAEE----EAMEELLQNEVNRQGVDIE------- 167
+ I+E L+ GA + A G +P+ +A + + + LLQ + + ++
Sbjct: 285 VRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHV 344
Query: 168 AARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNI 227
AA R+ A+ L+ G + R A +G T LH+A K + V++LL++ G ++
Sbjct: 345 AAHCGHHRV----AKVLLDKGAKPNSR-ALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399
Query: 228 KDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVA----DEDILGYLEEL 283
G TPLH A+ G + L+ + N +T +A ++ YL +
Sbjct: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQN 459
Query: 284 QKKQNLLHSEKRDKKSPL 301
+ K N ++ +D ++PL
Sbjct: 460 KAKVN---AKAKDDQTPL 474
Score = 89.0 bits (219), Expect = 2e-17
Identities = 71/245 (28%), Positives = 107/245 (43%), Gaps = 7/245 (2%)
Query: 35 KVKFDDGAVFLAACSSGD-TDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLV 93
+ K +G + + GD D V LL A+I+ +D LT LH A + + K L+
Sbjct: 299 QAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL 358
Query: 94 ENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEE 153
+ GA N G+ PLH A ++ + E L+ GA + AV G TPL +A
Sbjct: 359 DKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLP 418
Query: 154 LLQNEVNR------QGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAA 207
+++N + R V +E R + ++L AK T LH AA
Sbjct: 419 IVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAA 478
Query: 208 AKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQT 267
G+T ++KLL++ + N+ G TPLH AA G E L++ + K G T
Sbjct: 479 RIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFT 538
Query: 268 AFDVA 272
VA
Sbjct: 539 PLHVA 543
Score = 88.2 bits (217), Expect = 4e-17
Identities = 82/287 (28%), Positives = 125/287 (43%), Gaps = 42/287 (14%)
Query: 56 VLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAAS 115
V LL RGA N +NV T LH A + ++ K+L++N A +N + PLH AA
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479
Query: 116 CGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEE----LLQNEVNRQGVDIE---- 167
G+ ++ + L+ A+ + G TPL IA E E LL+ E ++ + +
Sbjct: 480 IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTP 539
Query: 168 ---AAR----KEEERIMLRDA------RQWLNSGHINDVRH------------------- 195
AA+ + E ++ RDA + L H+ V H
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHV-AVHHNNLDIVKLLLPRGGSPHSP 598
Query: 196 AKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNL 255
A +G T LH+AA + EV + L+Q G N + G TPLH AA G E +L+
Sbjct: 599 AWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQ 658
Query: 256 CDMEMVNKVGQTAFD-VADEDILGYLEELQKKQNLLHSEKRDKKSPL 301
+ + NK G T VA E + + L K ++ + R +PL
Sbjct: 659 ANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPL 705
Score = 82.8 bits (203), Expect = 2e-15
Identities = 81/286 (28%), Positives = 116/286 (40%), Gaps = 56/286 (19%)
Query: 47 ACSSGDTDEVLKLLHRGADINYANVD---------------------------------G 73
A G+ V LL RGA I D G
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305
Query: 74 LTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVG 133
L+ +H A D++D V+ L++ A I+ + PLH AA CG+ +A+ L+ +GA
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365
Query: 134 AVNSEGDTPLDIA----EEEAMEELLQNEVNRQGVDIEAARKEEERIM--------LRDA 181
+ G TPL IA ME LL + G I+A + + L
Sbjct: 366 SRALNGFTPLHIACKKNHVRVMELLL-----KTGASIDAVTESGLTPLHVASFMGHLPIV 420
Query: 182 RQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAH 241
+ L G +V + K T LH+AA G+TEV K L+Q VN K D TPLH AA
Sbjct: 421 KNLLQRGASPNVSNVKV-ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479
Query: 242 WGKEEACRILVDNLCDMEMVNKVGQTAFDVAD-----EDILGYLEE 282
G ++L++N + + G T +A E +L LE+
Sbjct: 480 IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEK 525
Score = 80.5 bits (197), Expect = 8e-15
Identities = 63/218 (28%), Positives = 95/218 (43%), Gaps = 18/218 (8%)
Query: 47 ACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEG 106
AC + LL GA I+ GLT LH A ++ +VK L++ GA+ N + +
Sbjct: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 437
Query: 107 WIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLD----IAEEEAMEELLQNEVN-- 160
PLH AA G+ ++A++L+ A V A + TPL I ++ LL+N N
Sbjct: 438 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 497
Query: 161 ------RQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEV 214
+ I A E ++ L + K G T LHVAA G V
Sbjct: 498 LATTAGHTPLHIAAREGHVETVLA------LLEKEASQACMTKKGFTPLHVAAKYGKVRV 551
Query: 215 LKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILV 252
+LL++ N +G TPLH A H + ++L+
Sbjct: 552 AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL 589
Score = 70.9 bits (172), Expect = 6e-12
Identities = 69/261 (26%), Positives = 109/261 (41%), Gaps = 25/261 (9%)
Query: 34 TKVKFDDGAVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLV 93
TK K A+ +AA + DT LL + + + G T LH A +N+++ + L+
Sbjct: 168 TKGKVRLPALHIAA-RNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLL 226
Query: 94 ENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEA--- 150
GA++N G PLH A+ G + + L+ +GA + + TPL A
Sbjct: 227 NRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVR 286
Query: 151 MEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGG---------- 200
+ E+L + G I+A K L H++ VR
Sbjct: 287 ISEILLD----HGAPIQAKTKNG----LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH 338
Query: 201 -TALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDME 259
T LHVAA G+ V K+L+ G N + +G+TPLH A +L+ ++
Sbjct: 339 LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398
Query: 260 MVNKVGQTAFDVADEDILGYL 280
V + G T VA +G+L
Sbjct: 399 AVTESGLTPLHVA--SFMGHL 417
Score = 60.8 bits (146), Expect = 6e-09
Identities = 45/188 (23%), Positives = 82/188 (43%), Gaps = 27/188 (14%)
Query: 66 INYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFL 125
+ + D T+ +A N+D + NG +IN + G LH A+ G++ + L
Sbjct: 5 VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64
Query: 126 IGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWL 185
+ + + +G+T L IA +E+++ VN G ++ A
Sbjct: 65 LHKEIILETTTKKGNTALHIAALAGQDEVVRELVN-YGANVNA----------------- 106
Query: 186 NSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKE 245
++ G T L++AA + + EV+K L++ G + N+ DG+TPL A G E
Sbjct: 107 ---------QSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHE 157
Query: 246 EACRILVD 253
L++
Sbjct: 158 NVVAHLIN 165
Score = 57.8 bits (138), Expect = 5e-08
Identities = 40/134 (29%), Positives = 57/134 (42%), Gaps = 33/134 (24%)
Query: 47 ACSSGDTDEVLKLLHRGADINYANVDGLTALHQACID----------------------- 83
A G + V LL + A+ N N GLT LH +
Sbjct: 642 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 701
Query: 84 ----------DNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVG 133
N+ +VKFL+++ A++N G+ PLH AA G+ DI L+ GA
Sbjct: 702 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761
Query: 134 AVNSEGDTPLDIAE 147
V+S+G TPL IA+
Sbjct: 762 EVSSDGTTPLAIAK 775
Score = 53.1 bits (126), Expect = 1e-06
Identities = 36/122 (29%), Positives = 59/122 (48%), Gaps = 11/122 (9%)
Query: 51 GDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPL 110
G+ V LL AD+N G + LHQA + D+V L++NGA+ N+ ++G PL
Sbjct: 712 GNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPL 771
Query: 111 HAAASCGYLDIAE----------FLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVN 160
A GY+ + + F++ H + D LD++E+E EEL+ +
Sbjct: 772 AIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEG-EELISFKAE 830
Query: 161 RQ 162
R+
Sbjct: 831 RR 832
Score = 32.0 bits (71), Expect = 3.1
Identities = 24/97 (24%), Positives = 49/97 (50%), Gaps = 4/97 (4%)
Query: 197 KSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLC 256
++G LH+A+ +G+ +++ L+ + G T LH AA G++E R LV+
Sbjct: 43 QNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGA 102
Query: 257 DMEMVNKVGQTAFDVADE----DILGYLEELQKKQNL 289
++ ++ G T +A + +++ +L E QN+
Sbjct: 103 NVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 139
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.304 0.121 0.321
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,073,296
Number of Sequences: 37866
Number of extensions: 1896823
Number of successful extensions: 60938
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1130
Number of HSP's successfully gapped in prelim test: 1409
Number of HSP's that attempted gapping in prelim test: 15066
Number of HSP's gapped (non-prelim): 21438
length of query: 1030
length of database: 18,247,518
effective HSP length: 112
effective length of query: 918
effective length of database: 14,006,526
effective search space: 12857990868
effective search space used: 12857990868
T: 11
A: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.