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Search of human proteins with 4504659
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4504659 interleukin 1 receptor, type I precursor [Homo
sapiens]
(569 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4504659 interleukin 1 receptor, type I precursor [Homo sapiens] 1167 0.0
gi|28416902 interleukin 1 receptor-like 2 precursor [Homo sapiens] 385 e-107
gi|27894324 interleukin 1 receptor-like 1 isoform 1 precursor [H... 224 2e-58
gi|11225607 interleukin 1 receptor accessory protein-like 2 [Hom... 212 6e-55
gi|7657232 interleukin 1 receptor accessory protein-like 1 precu... 194 1e-49
gi|4504655 interleukin 18 receptor 1 precursor [Homo sapiens] 190 3e-48
gi|4504661 interleukin 1 receptor accessory protein isoform 1 [H... 153 5e-37
gi|4504657 interleukin 18 receptor accessory protein precursor [... 136 6e-32
gi|27894334 interleukin 1 receptor, type II precursor [Homo sapi... 124 2e-28
gi|4758598 interleukin 1 receptor, type II precursor [Homo sapiens] 124 2e-28
gi|27894328 interleukin 1 receptor-like 1 isoform 2 precursor [H... 93 6e-19
gi|19882209 interleukin 1 receptor accessory protein isoform 2 [... 83 8e-16
gi|205277451 single Ig IL-1R-related molecule [Homo sapiens] 69 2e-11
gi|205277449 single Ig IL-1R-related molecule [Homo sapiens] 69 2e-11
gi|205277445 single Ig IL-1R-related molecule [Homo sapiens] 69 2e-11
gi|118572606 hemicentin 1 [Homo sapiens] 59 2e-08
gi|110349719 titin isoform N2-A [Homo sapiens] 54 5e-07
gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo ... 53 7e-07
gi|81158226 neuronal cell adhesion molecule isoform A precursor ... 53 9e-07
gi|81158224 neuronal cell adhesion molecule isoform B precursor ... 53 9e-07
gi|47524177 fibroblast growth factor receptor 4 isoform 2 precur... 52 1e-06
gi|47524175 fibroblast growth factor receptor 4 isoform 1 precur... 52 1e-06
gi|47524173 fibroblast growth factor receptor 4 isoform 1 precur... 52 1e-06
gi|54607118 leucine-rich repeats and immunoglobulin-like domains... 52 1e-06
gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens] 50 7e-06
gi|237858679 neurofascin isoform 3 precursor [Homo sapiens] 49 2e-05
gi|237858677 neurofascin isoform 2 precursor [Homo sapiens] 49 2e-05
gi|89903008 neurofascin isoform 4 precursor [Homo sapiens] 49 2e-05
gi|237858682 neurofascin isoform 6 precursor [Homo sapiens] 49 2e-05
gi|237858680 neurofascin isoform 5 precursor [Homo sapiens] 49 2e-05
>gi|4504659 interleukin 1 receptor, type I precursor [Homo sapiens]
Length = 569
Score = 1167 bits (3019), Expect = 0.0
Identities = 569/569 (100%), Positives = 569/569 (100%)
Query: 1 MKVLLRLICFIALLISSLEADKCKEREEKIILVSSANEIDVRPCPLNPNEHKGTITWYKD 60
MKVLLRLICFIALLISSLEADKCKEREEKIILVSSANEIDVRPCPLNPNEHKGTITWYKD
Sbjct: 1 MKVLLRLICFIALLISSLEADKCKEREEKIILVSSANEIDVRPCPLNPNEHKGTITWYKD 60
Query: 61 DSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSSYCLRIKISAKFVENEPNL 120
DSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSSYCLRIKISAKFVENEPNL
Sbjct: 61 DSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSSYCLRIKISAKFVENEPNL 120
Query: 121 CYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKDCKPLLLDNIHFSGVKDR 180
CYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKDCKPLLLDNIHFSGVKDR
Sbjct: 121 CYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKDCKPLLLDNIHFSGVKDR 180
Query: 181 LIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLEENKPTRPVIVSPANETMEVDL 240
LIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLEENKPTRPVIVSPANETMEVDL
Sbjct: 181 LIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLEENKPTRPVIVSPANETMEVDL 240
Query: 241 GSQIQLICNVTGQLSDIAYWKWNGSVIDEDDPVLGEDYYSVENPANKRRSTLITVLNISE 300
GSQIQLICNVTGQLSDIAYWKWNGSVIDEDDPVLGEDYYSVENPANKRRSTLITVLNISE
Sbjct: 241 GSQIQLICNVTGQLSDIAYWKWNGSVIDEDDPVLGEDYYSVENPANKRRSTLITVLNISE 300
Query: 301 IESRFYKHPFTCFAKNTHGIDAAYIQLIYPVTNFQKHMIGICVTLTVIIVCSVFIYKIFK 360
IESRFYKHPFTCFAKNTHGIDAAYIQLIYPVTNFQKHMIGICVTLTVIIVCSVFIYKIFK
Sbjct: 301 IESRFYKHPFTCFAKNTHGIDAAYIQLIYPVTNFQKHMIGICVTLTVIIVCSVFIYKIFK 360
Query: 361 IDIVLWYRDSCYDFLPIKASDGKTYDAYILYPKTVGEGSTSDCDIFVFKVLPEVLEKQCG 420
IDIVLWYRDSCYDFLPIKASDGKTYDAYILYPKTVGEGSTSDCDIFVFKVLPEVLEKQCG
Sbjct: 361 IDIVLWYRDSCYDFLPIKASDGKTYDAYILYPKTVGEGSTSDCDIFVFKVLPEVLEKQCG 420
Query: 421 YKLFIYGRDDYVGEDIVEVINENVKKSRRLIIILVRETSGFSWLGGSSEEQIAMYNALVQ 480
YKLFIYGRDDYVGEDIVEVINENVKKSRRLIIILVRETSGFSWLGGSSEEQIAMYNALVQ
Sbjct: 421 YKLFIYGRDDYVGEDIVEVINENVKKSRRLIIILVRETSGFSWLGGSSEEQIAMYNALVQ 480
Query: 481 DGIKVVLLELEKIQDYEKMPESIKFIKQKHGAIRWSGDFTQGPQSAKTRFWKNVRYHMPV 540
DGIKVVLLELEKIQDYEKMPESIKFIKQKHGAIRWSGDFTQGPQSAKTRFWKNVRYHMPV
Sbjct: 481 DGIKVVLLELEKIQDYEKMPESIKFIKQKHGAIRWSGDFTQGPQSAKTRFWKNVRYHMPV 540
Query: 541 QRRSPSSKHQLLSPATKEKLQREAHVPLG 569
QRRSPSSKHQLLSPATKEKLQREAHVPLG
Sbjct: 541 QRRSPSSKHQLLSPATKEKLQREAHVPLG 569
>gi|28416902 interleukin 1 receptor-like 2 precursor [Homo sapiens]
Length = 575
Score = 385 bits (989), Expect = e-107
Identities = 232/562 (41%), Positives = 325/562 (57%), Gaps = 32/562 (5%)
Query: 7 LICFIALLIS-SLEADKCKEREEKIILVSSANEIDVRPCPLNP-NEHKGTITWYKDDSKT 64
L+C +++ + S+ AD CK+ K ++S++ C P + ++TWYK+ SK
Sbjct: 5 LLCGLSIALPLSVTADGCKDIFMKNEILSASQPFAFN-CTFPPITSGEVSVTWYKNSSKI 63
Query: 65 PVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSSYCLRIKISAKFVENE------- 117
PVS SRIHQ + + F+P + DSG Y CV++ C RI ++ E
Sbjct: 64 PVSKIIQSRIHQDETWILFLPMEWGDSGVYQCVIKGRDSCHRIHVNLTVFEKHWCDTSIG 123
Query: 118 --PNLCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKDCKPLLLDNIHFS 175
PNL +KQ L + D L C ++ F K+ L ++WYKDC + + F+
Sbjct: 124 GLPNLSDE----YKQILHLGKDDSLTC-HLHFPKS--CVLGPIKWYKDCNEIKGER--FT 174
Query: 176 GVKDRLIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLEENK--PTRPVIVSPAN 233
++ RL+V NV+ + RGNY C A T+ GKQY + I E + P I+ P N
Sbjct: 175 VLETRLLVSNVSAEDRGNYACQAILTHSGKQYEVLNGITVSITERAGYGGSVPKIIYPKN 234
Query: 234 ETMEVDLGSQIQLICNVTGQL--SDIAYWKWNGSVIDEDDPVLGEDYYSVENPANKRRST 291
++EV LG+ + + CNVT +++ W+ N +++D+ VE + R
Sbjct: 235 HSIEVQLGTTLIVDCNVTDTKDNTNLRCWRVNNTLVDDYYDESKRIREGVETHVSFREHN 294
Query: 292 LITV-LNISEIESRFYKHPFTCFAKNTHGIDAAYIQLIYPVTNFQKHMIGICVTLTVIIV 350
L TV + E++ Y PF C A G+ AYI L P +F+ ++IG + L + V
Sbjct: 295 LYTVNITFLEVKMEDYGLPFMCHA----GVSTAYIILQLPAPDFRAYLIGGLIALVAVAV 350
Query: 351 CSVFIYKIFKIDIVLWYRDSCYDFLPIKASDGKTYDAYILYPKTVGEGSTSDCDIFVFKV 410
V+IY IFKIDIVLWYR + + I DGK YDAY+LYPK E D V +
Sbjct: 351 SVVYIYNIFKIDIVLWYRSAFHSTETIV--DGKLYDAYVLYPKPHKESQRHAVDALVLNI 408
Query: 411 LPEVLEKQCGYKLFIYGRDDYVGEDIVEVINENVKKSRRLIIILVRETSGFSWLGGSSEE 470
LPEVLE+QCGYKLFI+GRD++ G+ + VI+ENVK RRLI+I+V E+ GF L SEE
Sbjct: 409 LPEVLERQCGYKLFIFGRDEFPGQAVANVIDENVKLCRRLIVIVVPESLGFGLLKNLSEE 468
Query: 471 QIAMYNALVQDGIKVVLLELEKIQDYEKMPESIKFIKQKHGAIRWSGDFTQGPQSAKTRF 530
QIA+Y+AL+QDG+KV+L+ELEKI+DY MPESI++IKQKHGAIRW GDFT+ Q KT+F
Sbjct: 469 QIAVYSALIQDGMKVILIELEKIEDYTVMPESIQYIKQKHGAIRWHGDFTEQSQCMKTKF 528
Query: 531 WKNVRYHMPVQRRSPSSKHQLL 552
WK VRYHMP +R P QLL
Sbjct: 529 WKTVRYHMPPRRCRPFPPVQLL 550
>gi|27894324 interleukin 1 receptor-like 1 isoform 1 precursor [Homo
sapiens]
Length = 556
Score = 224 bits (570), Expect = 2e-58
Identities = 156/546 (28%), Positives = 265/546 (48%), Gaps = 42/546 (7%)
Query: 37 NEIDVRPCPLNPNEHKGTITWYKDDSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYC 96
NE + CP + T+ WY + + T++ +R+ + L F+PA V DSG Y C
Sbjct: 29 NEALIVRCP-RQGKPSYTVDWYYSQTNKSIPTQERNRVFASGQLLKFLPAAVADSGIYTC 87
Query: 97 VVRNSSYCLRIKISAKFVENEPNLCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELP 156
+VR+ ++ + + + + ++ + + CP ++ + N
Sbjct: 88 IVRSPTFNRTGYANVTIYKKQSDCNVPDYLMYSTVSGSEKNSKIYCPTIDLY----NWTA 143
Query: 157 KLQWYKDCKPLLLDNIHFSGVKDRLIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFI 216
L+W+K+C+ L + K L++ NV + G+YTC + G Y +T F
Sbjct: 144 PLEWFKNCQAL--QGSRYRAHKSFLVIDNVMTEDAGDYTCKFIHNENGANYSVTATRSFT 201
Query: 217 TLEENKPTR-PVIVSPA-NETMEVDLGSQIQLICNVT----GQLSDIAYWKWNGSVIDED 270
+E + PVI +PA NE EV++G L C+ Q W+ NG+ I +
Sbjct: 202 VKDEQGFSLFPVIGAPAQNEIKEVEIGKNANLTCSACFGKGTQFLAAVLWQLNGTKITD- 260
Query: 271 DPVLGEDYYSVENPANKRRST----LITVLNISEIESRFYKHPFTCFAKNTHGIDAAYIQ 326
GE E N+ S L VL I++++ + C A N HG+ ++
Sbjct: 261 ---FGEPRIQQEEGQNQSFSNGLACLDMVLRIADVKEEDLLLQYDCLALNLHGLRRHTVR 317
Query: 327 LIY--PVTNFQKH-MIGICVTLTVIIVCSVFIYKIFKIDIVLWYRDSCYDFLPIKASDGK 383
L P+ + + +I +C ++I V I K+F I+ L +RD + +DGK
Sbjct: 318 LSRKNPIDHHSIYCIIAVCSVFLMLINVLVIILKMFWIEATLLWRDIAKPYKT--RNDGK 375
Query: 384 TYDAYILYPKTVGEGS--TSDCDIFVFKVLPEVLEKQCGYKLFIYGRDDYVGEDIVEVIN 441
YDAY++YP+ + S + FV ++LP+VLE +CGY L IYGRD GED+V +
Sbjct: 376 LYDAYVVYPRNYKSSTDGASRVEHFVHQILPDVLENKCGYTLCIYGRDMLPGEDVVTAVE 435
Query: 442 ENVKKSRRLIIIL---VRETSGFSWLGGSSEEQIAMYNALVQDGIKVVLLELEKIQDY-- 496
N++KSRR I IL + F++ E+++A++ AL+Q+ KV+L+E+E + +
Sbjct: 436 TNIRKSRRHIFILTPQITHNKEFAY-----EQEVALHCALIQNDAKVILIEMEALSELDM 490
Query: 497 ---EKMPESIKFIKQKHGAIRWSGDFTQGPQSAKTRFWKNVRYHMPVQRRSPSSKHQLLS 553
E + +S++ + + G I+W D +S ++FWK+VRY MPV + P K L+
Sbjct: 491 LQAEALQDSLQHLMKVQGTIKWREDHIANKRSLNSKFWKHVRYQMPVPSKIP-RKASSLT 549
Query: 554 PATKEK 559
P +K
Sbjct: 550 PLAAQK 555
>gi|11225607 interleukin 1 receptor accessory protein-like 2 [Homo
sapiens]
Length = 686
Score = 212 bits (540), Expect = 6e-55
Identities = 153/521 (29%), Positives = 257/521 (49%), Gaps = 41/521 (7%)
Query: 55 ITWYKD--DSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSSYCLRIKISAK 112
+ WYK+ D + P+ + R+ + ++ +WF A+ +DSG Y CV+RNS+YC+++ +S
Sbjct: 74 LMWYKNKGDLEEPIIFSEV-RMSKEEDSIWFHSAEAQDSGFYTCVLRNSTYCMKVSMSLT 132
Query: 113 FVENEPNLCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKDCKPLLLDNI 172
ENE LCYN++ + +K V + CP M+ FK + E P + WYK+CKP + +I
Sbjct: 133 VAENESGLCYNSRIRYLEKSEVTKRKEISCPDMDDFKKSDQE-PDVVWYKECKPKMWRSI 191
Query: 173 HFSGVKDRLIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLEENKPTRPVI-VSP 231
+ L++ V E+ GNYTC Y GK T ++ L +KP +P+ +
Sbjct: 192 IIQ-KGNALLIQEVQEEDGGNYTCELKYE--GKLVRRTTELKVTALLTDKPPKPLFPMEN 248
Query: 232 ANETMEVDLGSQIQLICNV----TGQLSDIAYWKWNGSVIDEDDPVLGEDYYSVENPANK 287
++V LG + + C +G+ + YW I+E + E +
Sbjct: 249 QPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIEELAGHIREGEIRLLKEHLG 308
Query: 288 RRSTLITVLNISEIESRFYKHPFTCFAKNTHGIDAAYIQLIYPVTNFQKHMIGICVTLTV 347
+ + ++ S +E+ +TC +N +G A + L ++ + G + +
Sbjct: 309 EKEVELALIFDSVVEADLAN--YTCHVENRNGRKHASVLLRKKDLIYKIELAGGLGAIFL 366
Query: 348 IIVCSVFIYKIFKIDIVLWYRDSCYDFLPIKASDGKTYDAYILYPKTVGEGSTSDCD--- 404
++V V IYK + I+++L+YR + D K YDAY+ Y K + T DCD
Sbjct: 367 LLVLLVVIYKCYNIELMLFYRQ--HFGADETNDDNKEYDAYLSYTKV--DQDTLDCDNPE 422
Query: 405 --IFVFKVLPEVLEKQCGYKLFIYGRDDYVGEDIVEVINENVKKSRRLIIILVRETSGFS 462
F +VLP+VLEK GYKLFI RD +E + V++SRRLII+L T +
Sbjct: 423 EEQFALEVLPDVLEKHYGYKLFIPERDLIPSGTYMEDLTRYVEQSRRLIIVL---TPDYI 479
Query: 463 WLGGSS--EEQIAMYNALVQDGIKVVLLELEKI------QDYEKMPESIKFIKQKHGAIR 514
G S E + ++N LV IKV+L+E ++ Q+ E + SIK + I+
Sbjct: 480 LRRGWSIFELESRLHNMLVSGEIKVILIECTELKGKVNCQEVESLKRSIKLL----SLIK 535
Query: 515 WSGDFTQGPQSAKTRFWKNVRYHMPVQRRSPSSKHQLLSPA 555
W G + ++FWK++ Y MP++++ + +L A
Sbjct: 536 WKGSKS---SKLNSKFWKHLVYEMPIKKKEMLPRCHVLDSA 573
>gi|7657232 interleukin 1 receptor accessory protein-like 1
precursor [Homo sapiens]
Length = 696
Score = 194 bits (494), Expect = 1e-49
Identities = 153/524 (29%), Positives = 257/524 (49%), Gaps = 48/524 (9%)
Query: 54 TITWYKD----DSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSSYCLRIKI 109
++ WYK D + P++ + SR+ + ++ +WF P ++DSG Y CV+RNS+YC+++ I
Sbjct: 73 SLMWYKSSGPGDFEEPIAFD-GSRMSKEEDSIWFRPTLLQDSGLYACVIRNSTYCMKVSI 131
Query: 110 SAKFVENEPNLCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKDCK-PLL 168
S EN+ LCYN++ + +K ++ + C +E F E P++ WYK+C+
Sbjct: 132 SLTVGENDTGLCYNSKMKYFEKAELSKSKEISCRDIEDFLLPTRE-PEILWYKECRTKTW 190
Query: 169 LDNIHFSGVKDRLIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLEENKPTRPVI 228
+I F +D L++ V E GNYTC Y + + R E P +
Sbjct: 191 RPSIVFK--RDTLLIREVREDDIGNYTCELKY----GGFVVRRTTELTVTAPLTDKPPKL 244
Query: 229 VSPANETM---EVDLGSQIQLICNV----TGQLSDIAYW-KWNGSVIDEDDPVLGEDYYS 280
+ P + E LG L C +G +S + YW K + D D+ + E
Sbjct: 245 LYPMESKLTIQETQLGDSANLTCRAFFGYSGDVSPLIYWMKGEKFIEDLDENRVWESDIR 304
Query: 281 V--ENPANKRRSTLITVLNISEIESRFYKHPFTCFAKNTHGIDAAYIQLIYPVTNFQKHM 338
+ E+ + S + V ++ E + Y +C+ +N +G A + L + +
Sbjct: 305 ILKEHLGEQEVSISLIVDSVEEGDLGNY----SCYVENGNGRRHASVLLHKRELMYTVEL 360
Query: 339 IGICVTLTVIIVCSVFIYKIFKIDIVLWYRDSCYDFLPIKASDGKTYDAYILYPKTVGE- 397
G + +++VC V IYK +KI+I+L+YR+ + D K YDAY+ Y K +
Sbjct: 361 AGGLGAILLLLVCLVTIYKCYKIEIMLFYRN--HFGAEELDGDNKDYDAYLSYTKVDPDQ 418
Query: 398 --GSTSDCDIFVFKVLPEVLEKQCGYKLFIYGRDDYVGEDIVEVINENVKKSRRLIIILV 455
T + + F ++LP++LEK GYKLFI RD +E + V +S+RLII++
Sbjct: 419 WNQETGEEERFALEILPDMLEKHYGYKLFIPDRDLIPTGTYIEDVARCVDQSKRLIIVM- 477
Query: 456 RETSGFSWLGGSS--EEQIAMYNALVQDGIKVVLL---ELEKIQDYEKMPESIKFIKQKH 510
T + G S E + + N LV IKV+L+ EL I +Y+++ E++K +
Sbjct: 478 --TPNYVVRRGWSIFELETRLRNMLVTGEIKVILIECSELRGIMNYQEV-EALKHTIKLL 534
Query: 511 GAIRWSGDFTQGPQSAK--TRFWKNVRYHMPVQRRSPSSKHQLL 552
I+W GP+ K ++FWK ++Y MP +R P + Q L
Sbjct: 535 TVIKW-----HGPKCNKLNSKFWKRLQYEMPFKRIEPITHEQAL 573
>gi|4504655 interleukin 18 receptor 1 precursor [Homo sapiens]
Length = 541
Score = 190 bits (482), Expect = 3e-48
Identities = 151/560 (26%), Positives = 254/560 (45%), Gaps = 45/560 (8%)
Query: 13 LLISSLEADKCKEREEKIILVSSANEIDVRPCPLNPNEHKGTITWYKDDSK---TPVSTE 69
+LIS A+ C R ++ + C L T +WYK ++
Sbjct: 12 VLISVSTAESCTSRPHITVVEGEPFYLKHCSCSLAHEIETTTKSWYKSSGSQEHVELNPR 71
Query: 70 QASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSSYCLRIKISAKFVENEPNLCYNAQAIFK 129
+SRI H L F P ++ D+G Y+ ++N + ++ + + + C+ + +
Sbjct: 72 SSSRIALHDCVLEFWPVELNDTGSYFFQMKNYTQKWKLNV----IRRNKHSCFTERQVTS 127
Query: 130 QKLPVAGDGGLVCP--YMEFFKNENNELPKLQWYKDCKPLLLDNIHFSGVKDRLIVMNVA 187
+ + V + C Y + N + YK+CK LLL+N K+ I N
Sbjct: 128 KIVEVKKFFQITCENSYYQTLVNSTS------LYKNCKKLLLENN-----KNPTIKKNAE 176
Query: 188 EKHRGNYTCHASYTYLGKQYPITRVIEFITLEENKPTRPVIVSPANETMEVDLGSQIQLI 247
+ +G Y+C + GK + IT+ +E+ PV++ P + V+LG ++L
Sbjct: 177 FEDQGYYSCVHFLHHNGKLFNITKTFNITIVEDRSNIVPVLLGPKLNHVAVELGKNVRLN 236
Query: 248 CNVTGQLSDIAYWKWNGSVIDEDDPVLGEDYYSVENPANKRRSTLITVLNISEIESRFYK 307
C+ D+ YW + G D + E + P K ++ VL I I
Sbjct: 237 CSALLNEEDVIYWMF-GEENGSDPNIHEEKEMRIMTPEGKWHAS--KVLRIENIGESNLN 293
Query: 308 HPFTCFAKNTHGIDAAYIQLI-------YPVTNFQKHMIGICVTLTVIIVCSVFIYKIFK 360
+ C +T G D L+ P F + MI I V + V +VC V + I++
Sbjct: 294 VLYNCTVASTGGTDTKSFILVRKADMADIPGHVFTRGMI-IAVLILVAVVCLVTVCVIYR 352
Query: 361 IDIVLWYRDSCYDFLPIKASDGKTYDAYILYPKTVGEGSTSDCDIFVFKVLPEVLEKQCG 420
+D+VL+YR + +DGKTYDA++ Y K + + F ++LP VLEK G
Sbjct: 353 VDLVLFYRHLTRRDETL--TDGKTYDAFVSYLKECRPENGEE-HTFAVEILPRVLEKHFG 409
Query: 421 YKLFIYGRDDYVGEDIVEVINENVKKSRRLIIILVRETSGFSWLGGS--SEEQIAMYNAL 478
YKL I+ RD G +V+ I+ ++KSRRLII+L + S++ E + ++ AL
Sbjct: 410 YKLCIFERDVVPGGAVVDEIHSLIEKSRRLIIVLSK-----SYMSNEVRYELESGLHEAL 464
Query: 479 VQDGIKVVLLELEKIQDYEKMPESIKFIKQKHGAIRWSGDFTQGPQSAKTRFWKNVRYHM 538
V+ IK++L+E + D+ +P+S+K +K H ++W D + S +RFWKN+ Y M
Sbjct: 465 VERKIKIILIEFTPVTDFTFLPQSLKLLK-SHRVLKWKADKS---LSYNSRFWKNLLYLM 520
Query: 539 PVQRRSPSSKHQLLSPATKE 558
P + P + P E
Sbjct: 521 PAKTVKPGRDEPEVLPVLSE 540
>gi|4504661 interleukin 1 receptor accessory protein isoform 1 [Homo
sapiens]
Length = 570
Score = 153 bits (386), Expect = 5e-37
Identities = 129/524 (24%), Positives = 241/524 (45%), Gaps = 51/524 (9%)
Query: 54 TITWY----KDDSKTPVSTE-QASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSSYCLRIK 108
T+ WY D + P++ +RI + K+ LWF P + D+G+Y C++RN++YC ++
Sbjct: 67 TLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVA 126
Query: 109 ISAKFVENEPNLCYNAQAIFKQKLPV------AGDGGLVCPYMEFFKNENNELPKLQWYK 162
+ V+ + C+N+ KLPV G + CP ++ + ++ P + WY
Sbjct: 127 FPLEVVQKDS--CFNS----PMKLPVHKLYIEYGIQRITCPNVDGY-FPSSVKPTITWYM 179
Query: 163 DC-KPLLLDNIHFSGVKDRLIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLEEN 221
C K +N+ G+ ++ ++ + GNYTC +Y G+ + +TR + +
Sbjct: 180 GCYKIQNFNNVIPEGMNLSFLIALIS--NNGNYTCVVTYPENGRTFHLTRTLTVKVVGSP 237
Query: 222 KPTRPVIVSPANE--TMEVDLGSQIQLICNVTGQL----SDIAYWKWNGSVIDEDDPVLG 275
K P ++ N+ E + G ++ + C V + +W +G DD +
Sbjct: 238 KNAVPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGK--KPDDITID 295
Query: 276 EDYYSVENPANKRRSTLITVLNISEIESRFYKHPFTCFAKNTHG--IDAAYIQLIYPVTN 333
+ + T +L+I ++ S K + C A++ G AA ++ P
Sbjct: 296 VTINESISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAAKVKQKVPAPR 355
Query: 334 FQKHMIGICVTLTVIIVCSVFIYKIFKIDIVLWYRDSCYDFLPIKASDGKTYDAYILYPK 393
+ + +++V + +Y ++ +++VL+YR + DGK YD Y+ Y +
Sbjct: 356 YTVELACGFGATVLLVVILIVVYHVYWLEMVLFYR--AHFGTDETILDGKEYDIYVSYAR 413
Query: 394 TVGEGSTSDCDIFVFKVLPEVLEKQCGYKLFIYGRDDYVGEDIVEVINENVKKSRRLIII 453
E + FV L VLE + GYKL I+ RD G + + ++KSRRL+++
Sbjct: 414 NAEE------EEFVLLTLRGVLENEFGYKLCIFDRDSLPGGIVTDETLSFIQKSRRLLVV 467
Query: 454 LVRETSGFSWLGGSS--EEQIAMYNALVQDGIKVVLLELEKIQDYEKMPESIKFIKQKHG 511
L + + G + E + + N + I V+L++ + ++ E + +K K
Sbjct: 468 L---SPNYVLQGTQALLELKAGLENMASRGNINVILVQYKAVK--ETKVKELKRAKTVLT 522
Query: 512 AIRWSGDFTQGPQSAKTRFWKNVRYHMPVQR--RSPSSKHQLLS 553
I+W G+ ++ PQ RFWK ++ MPV++ R SS Q LS
Sbjct: 523 VIKWKGEKSKYPQG---RFWKQLQVAMPVKKSPRRSSSDEQGLS 563
>gi|4504657 interleukin 18 receptor accessory protein precursor
[Homo sapiens]
Length = 599
Score = 136 bits (342), Expect = 6e-32
Identities = 130/515 (25%), Positives = 226/515 (43%), Gaps = 42/515 (8%)
Query: 55 ITWYKDDSK-TPVSTEQASRIH--QHKEKLWFVPAKVEDSGHYYCVVR--NSSY----CL 105
+ WY+ S P+ + S H Q K L F+ V +SG Y C + S Y C+
Sbjct: 82 VQWYQQPSNGDPLEDIRKSYPHIIQDKCTLHFLTPGVNNSGSYICRPKMIKSPYDVACCV 141
Query: 106 RIKISAKFVENEPNLCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKDCK 165
++ + K + N A KQ L + G + CP + + + P + WYK+ K
Sbjct: 142 KMILEVK---PQTNASCEYSASHKQDLLLGSTGSISCPSLSC--QSDAQSPAVTWYKNGK 196
Query: 166 PLLLDNIHFSGVKDRLIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLEENKPTR 225
L ++ +R++V V + H+G Y C + + + + V++ T+ + +
Sbjct: 197 LLSVER------SNRIVVDEVYDYHQGTYVCDYTQSDTVSSWTVRAVVQVRTIVGDTKLK 250
Query: 226 PVIVSPANETMEVDLGSQIQLICNVTGQLSDI--AYWKWNGSVIDEDDPVLGEDYYSVEN 283
P I+ P +T+EV+LG + + C + KW D + V + S++
Sbjct: 251 PDILDPVEDTLEVELGKPLTISCKARFGFERVFNPVIKWYIKDSDLEWEVSVPEAKSIK- 309
Query: 284 PANKRRSTLITVLNISEIESRFYKHPFTCFAKNTHGIDAAYIQLIYPVTNFQKH-MIGIC 342
+ + + + + ++ R + F CF +N+ G +QL + ++G
Sbjct: 310 -STLKDEIIERNIILEKVTQRDLRRKFVCFVQNSIGNTTQSVQLKEKRGVVLLYILLGTI 368
Query: 343 VTLTVIIVCSVFIYKIFKIDIVLWYRDSCYDFLPIKASDGKTYDAYILYPKTVGEGSTSD 402
TL ++ S +Y+ + I+IVL YR Y D K +DA++ Y K S +
Sbjct: 369 GTLVAVLAASALLYRHW-IEIVLLYR--TYQSKDQTLGDKKDFDAFVSYAKWSSFPSEAT 425
Query: 403 CDI----FVFKVLPEVLEKQCGYKLFIYGRDDYVGEDIVEVINENVKKSRRLIIILVRET 458
+ + P+VLE + GY L + RD G E I +K+SRR I IL
Sbjct: 426 SSLSEEHLALSLFPDVLENKYGYSLCLLERDVAPGGVYAEDIVSIIKRSRRGIFIL---- 481
Query: 459 SGFSWLGGSS--EEQIAMYNALVQDGIKVVLLELEKIQDYEKMPESIKFIKQKHGAIRWS 516
+++ G S E Q A+ AL +K++L++ Q+ E +P +K + + W
Sbjct: 482 -SPNYVNGPSIFELQAAVNLALDDQTLKLILIKFCYFQEPESLPHLVKKALRVLPTVTWR 540
Query: 517 GDFTQGPQSAKTRFWKNVRYHMPVQRRSPSSKHQL 551
G + P S RFW +RYHMPV+ + +QL
Sbjct: 541 GLKSVPPNS---RFWAKMRYHMPVKNSQGFTWNQL 572
>gi|27894334 interleukin 1 receptor, type II precursor [Homo
sapiens]
Length = 398
Score = 124 bits (311), Expect = 2e-28
Identities = 79/224 (35%), Positives = 121/224 (54%), Gaps = 10/224 (4%)
Query: 55 ITWYKDDSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSSYCLRIKISAKFV 114
+TW+K+DS V E+ +R+ LW +PA EDSG Y C RN+SYC ++ I +
Sbjct: 67 LTWHKNDSARTVPGEEETRMWAQDGALWLLPALQEDSGTYVCTTRNASYCDKMSIELRVF 126
Query: 115 ENEPNLCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKDCKPLLLDNIHF 174
EN + + Q L ++ G LVCP + F + ++ K+QWYKD L DN F
Sbjct: 127 ENTD--AFLPFISYPQILTLSTSGVLVCPDLSEFTRDKTDV-KIQWYKDSLLLDKDNEKF 183
Query: 175 SGVK--DRLIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLEENKPTRPVIVSPA 232
V+ L+V +VA + G Y C ++ + G+QY ITR IE ++ + T PVI+SP
Sbjct: 184 LSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNITRSIELRIKKKKEETIPVIISPL 243
Query: 233 NETMEVDLGSQIQLICNV---TG-QLSDIAYWKWNGSVIDEDDP 272
+T+ LGS++ + C V TG L+ + +W N + I+ P
Sbjct: 244 -KTISASLGSRLTIPCKVFLGTGTPLTTMLWWTANDTHIESAYP 286
>gi|4758598 interleukin 1 receptor, type II precursor [Homo sapiens]
Length = 398
Score = 124 bits (311), Expect = 2e-28
Identities = 79/224 (35%), Positives = 121/224 (54%), Gaps = 10/224 (4%)
Query: 55 ITWYKDDSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSSYCLRIKISAKFV 114
+TW+K+DS V E+ +R+ LW +PA EDSG Y C RN+SYC ++ I +
Sbjct: 67 LTWHKNDSARTVPGEEETRMWAQDGALWLLPALQEDSGTYVCTTRNASYCDKMSIELRVF 126
Query: 115 ENEPNLCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKDCKPLLLDNIHF 174
EN + + Q L ++ G LVCP + F + ++ K+QWYKD L DN F
Sbjct: 127 ENTD--AFLPFISYPQILTLSTSGVLVCPDLSEFTRDKTDV-KIQWYKDSLLLDKDNEKF 183
Query: 175 SGVK--DRLIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLEENKPTRPVIVSPA 232
V+ L+V +VA + G Y C ++ + G+QY ITR IE ++ + T PVI+SP
Sbjct: 184 LSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNITRSIELRIKKKKEETIPVIISPL 243
Query: 233 NETMEVDLGSQIQLICNV---TG-QLSDIAYWKWNGSVIDEDDP 272
+T+ LGS++ + C V TG L+ + +W N + I+ P
Sbjct: 244 -KTISASLGSRLTIPCKVFLGTGTPLTTMLWWTANDTHIESAYP 286
>gi|27894328 interleukin 1 receptor-like 1 isoform 2 precursor [Homo
sapiens]
Length = 328
Score = 93.2 bits (230), Expect = 6e-19
Identities = 74/301 (24%), Positives = 129/301 (42%), Gaps = 21/301 (6%)
Query: 37 NEIDVRPCPLNPNEHKGTITWYKDDSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYC 96
NE + CP + T+ WY + + T++ +R+ + L F+PA V DSG Y C
Sbjct: 29 NEALIVRCP-RQGKPSYTVDWYYSQTNKSIPTQERNRVFASGQLLKFLPAAVADSGIYTC 87
Query: 97 VVRNSSYCLRIKISAKFVENEPNLCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELP 156
+VR+ ++ + + + + ++ + + CP ++ + N
Sbjct: 88 IVRSPTFNRTGYANVTIYKKQSDCNVPDYLMYSTVSGSEKNSKIYCPTIDLY----NWTA 143
Query: 157 KLQWYKDCKPLLLDNIHFSGVKDRLIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEF- 215
L+W+K+C+ L + K L++ NV + G+YTC + G Y +T F
Sbjct: 144 PLEWFKNCQ--ALQGSRYRAHKSFLVIDNVMTEDAGDYTCKFIHNENGANYSVTATRSFT 201
Query: 216 ITLEENKPTRPVIVSPA-NETMEVDLGSQIQLICNVT----GQLSDIAYWKWNGSVIDED 270
+ E+ PVI +PA NE EV++G L C+ Q W+ NG+ I +
Sbjct: 202 VKDEQGFSLFPVIGAPAQNEIKEVEIGKNANLTCSACFGKGTQFLAAVLWQLNGTKITD- 260
Query: 271 DPVLGEDYYSVENPANKRRST----LITVLNISEIESRFYKHPFTCFAKNTHGIDAAYIQ 326
GE E N+ S L VL I++++ + C A N HG+ ++
Sbjct: 261 ---FGEPRIQQEEGQNQSFSNGLACLDMVLRIADVKEEDLLLQYDCLALNLHGLRRHTVR 317
Query: 327 L 327
L
Sbjct: 318 L 318
>gi|19882209 interleukin 1 receptor accessory protein isoform 2
[Homo sapiens]
Length = 356
Score = 82.8 bits (203), Expect = 8e-16
Identities = 65/284 (22%), Positives = 127/284 (44%), Gaps = 29/284 (10%)
Query: 54 TITWY----KDDSKTPVSTE-QASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSSYCLRIK 108
T+ WY D + P++ +RI + K+ LWF P + D+G+Y C++RN++YC ++
Sbjct: 67 TLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVA 126
Query: 109 ISAKFVENEPNLCYNAQAIFKQKLPV------AGDGGLVCPYMEFFKNENNELPKLQWYK 162
+ V+ + C+N+ KLPV G + CP ++ + ++ P + WY
Sbjct: 127 FPLEVVQKDS--CFNS----PMKLPVHKLYIEYGIQRITCPNVDGY-FPSSVKPTITWYM 179
Query: 163 DC-KPLLLDNIHFSGVKDRLIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLEEN 221
C K +N+ G+ ++ ++ + GNYTC +Y G+ + +TR + +
Sbjct: 180 GCYKIQNFNNVIPEGMNLSFLIALIS--NNGNYTCVVTYPENGRTFHLTRTLTVKVVGSP 237
Query: 222 KPTRPVIVSPANE--TMEVDLGSQIQLICNVTGQL----SDIAYWKWNGSVIDEDDPVLG 275
K P ++ N+ E + G ++ + C V + +W +G DD +
Sbjct: 238 KNAVPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGK--KPDDITID 295
Query: 276 EDYYSVENPANKRRSTLITVLNISEIESRFYKHPFTCFAKNTHG 319
+ + T +L+I ++ S K + C A++ G
Sbjct: 296 VTINESISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKG 339
>gi|205277451 single Ig IL-1R-related molecule [Homo sapiens]
Length = 410
Score = 68.6 bits (166), Expect = 2e-11
Identities = 75/325 (23%), Positives = 145/325 (44%), Gaps = 36/325 (11%)
Query: 226 PVIVSPA-NETMEVDLGSQIQLICN---VTGQLSDIAYWKWNGSVIDEDDPVLGEDYYSV 281
P +SP+ ++ + LGS + L C V+G + +W + + P+ +YS+
Sbjct: 9 PDFLSPSEDQVLRPALGSSVALNCTAWVVSGPHCSLPSVQW----LKDGLPLGIGGHYSL 64
Query: 282 EN----PANKRRSTLITVLNISEIESRFYKHPFTCFAKNTHGIDAAYIQLIYPVTNFQKH 337
AN + +VL ++ + Y FTC +N + +Q P ++
Sbjct: 65 HEYSWVKANLSEVLVSSVLGVNVTSTEVYG-AFTCSIQNI-SFSSFTLQRAGPTSHVAAV 122
Query: 338 MIGICVTLTVIIVCSVFIYKIFKIDIVLWYRDSCYDFLPIKASDGKTYDAYILYPKTVGE 397
+ + V L +++ + +Y +++++LWY+D+ + ++ +DGK YDAY+ Y
Sbjct: 123 LASLLVLLALLL--AALLYVKCRLNVLLWYQDA---YGEVEINDGKLYDAYVSY------ 171
Query: 398 GSTSDCDI---FVFKVLPEVLEKQCGYKLFIYGRDDYVGEDIVEVINENVKKSRRLIIIL 454
SDC FV +L LE++ GYKLF+ RD + + N+ + RRLI++L
Sbjct: 172 ---SDCPEDRKFVNFILKPQLERRRGYKLFLDDRDLLPRAEPSADLLVNLSRCRRLIVVL 228
Query: 455 VRETSGFSWLGGSSEEQIAMYNALVQDGIKVVLLELEKIQDYEKMPESIKFIKQKHGAIR 514
+W S E + L + I + + Q + +++ ++Q H +
Sbjct: 229 SDAFLSRAWCSHSFREGLCRLLELTRRPIFITF----EGQRRDPAHPALRLLRQ-HRHLV 283
Query: 515 WSGDFTQGPQSAKTRFWKNVRYHMP 539
+ G + + FWK V+ +P
Sbjct: 284 TLLLWRPGSVTPSSDFWKEVQLALP 308
>gi|205277449 single Ig IL-1R-related molecule [Homo sapiens]
Length = 410
Score = 68.6 bits (166), Expect = 2e-11
Identities = 75/325 (23%), Positives = 145/325 (44%), Gaps = 36/325 (11%)
Query: 226 PVIVSPA-NETMEVDLGSQIQLICN---VTGQLSDIAYWKWNGSVIDEDDPVLGEDYYSV 281
P +SP+ ++ + LGS + L C V+G + +W + + P+ +YS+
Sbjct: 9 PDFLSPSEDQVLRPALGSSVALNCTAWVVSGPHCSLPSVQW----LKDGLPLGIGGHYSL 64
Query: 282 EN----PANKRRSTLITVLNISEIESRFYKHPFTCFAKNTHGIDAAYIQLIYPVTNFQKH 337
AN + +VL ++ + Y FTC +N + +Q P ++
Sbjct: 65 HEYSWVKANLSEVLVSSVLGVNVTSTEVYG-AFTCSIQNI-SFSSFTLQRAGPTSHVAAV 122
Query: 338 MIGICVTLTVIIVCSVFIYKIFKIDIVLWYRDSCYDFLPIKASDGKTYDAYILYPKTVGE 397
+ + V L +++ + +Y +++++LWY+D+ + ++ +DGK YDAY+ Y
Sbjct: 123 LASLLVLLALLL--AALLYVKCRLNVLLWYQDA---YGEVEINDGKLYDAYVSY------ 171
Query: 398 GSTSDCDI---FVFKVLPEVLEKQCGYKLFIYGRDDYVGEDIVEVINENVKKSRRLIIIL 454
SDC FV +L LE++ GYKLF+ RD + + N+ + RRLI++L
Sbjct: 172 ---SDCPEDRKFVNFILKPQLERRRGYKLFLDDRDLLPRAEPSADLLVNLSRCRRLIVVL 228
Query: 455 VRETSGFSWLGGSSEEQIAMYNALVQDGIKVVLLELEKIQDYEKMPESIKFIKQKHGAIR 514
+W S E + L + I + + Q + +++ ++Q H +
Sbjct: 229 SDAFLSRAWCSHSFREGLCRLLELTRRPIFITF----EGQRRDPAHPALRLLRQ-HRHLV 283
Query: 515 WSGDFTQGPQSAKTRFWKNVRYHMP 539
+ G + + FWK V+ +P
Sbjct: 284 TLLLWRPGSVTPSSDFWKEVQLALP 308
>gi|205277445 single Ig IL-1R-related molecule [Homo sapiens]
Length = 410
Score = 68.6 bits (166), Expect = 2e-11
Identities = 75/325 (23%), Positives = 145/325 (44%), Gaps = 36/325 (11%)
Query: 226 PVIVSPA-NETMEVDLGSQIQLICN---VTGQLSDIAYWKWNGSVIDEDDPVLGEDYYSV 281
P +SP+ ++ + LGS + L C V+G + +W + + P+ +YS+
Sbjct: 9 PDFLSPSEDQVLRPALGSSVALNCTAWVVSGPHCSLPSVQW----LKDGLPLGIGGHYSL 64
Query: 282 EN----PANKRRSTLITVLNISEIESRFYKHPFTCFAKNTHGIDAAYIQLIYPVTNFQKH 337
AN + +VL ++ + Y FTC +N + +Q P ++
Sbjct: 65 HEYSWVKANLSEVLVSSVLGVNVTSTEVYG-AFTCSIQNI-SFSSFTLQRAGPTSHVAAV 122
Query: 338 MIGICVTLTVIIVCSVFIYKIFKIDIVLWYRDSCYDFLPIKASDGKTYDAYILYPKTVGE 397
+ + V L +++ + +Y +++++LWY+D+ + ++ +DGK YDAY+ Y
Sbjct: 123 LASLLVLLALLL--AALLYVKCRLNVLLWYQDA---YGEVEINDGKLYDAYVSY------ 171
Query: 398 GSTSDCDI---FVFKVLPEVLEKQCGYKLFIYGRDDYVGEDIVEVINENVKKSRRLIIIL 454
SDC FV +L LE++ GYKLF+ RD + + N+ + RRLI++L
Sbjct: 172 ---SDCPEDRKFVNFILKPQLERRRGYKLFLDDRDLLPRAEPSADLLVNLSRCRRLIVVL 228
Query: 455 VRETSGFSWLGGSSEEQIAMYNALVQDGIKVVLLELEKIQDYEKMPESIKFIKQKHGAIR 514
+W S E + L + I + + Q + +++ ++Q H +
Sbjct: 229 SDAFLSRAWCSHSFREGLCRLLELTRRPIFITF----EGQRRDPAHPALRLLRQ-HRHLV 283
Query: 515 WSGDFTQGPQSAKTRFWKNVRYHMP 539
+ G + + FWK V+ +P
Sbjct: 284 TLLLWRPGSVTPSSDFWKEVQLALP 308
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 58.5 bits (140), Expect = 2e-08
Identities = 61/219 (27%), Positives = 94/219 (42%), Gaps = 18/219 (8%)
Query: 54 TITWYKDDSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSSYCLRIKISAKF 113
+ITW+KD PVS + RI L + +ED+G Y CVVRN++ R KI
Sbjct: 2417 SITWFKDG--WPVSLSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEER-KIFGLS 2473
Query: 114 VENEPNLCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKDCKPLLLDNIH 173
V P++ + K+ L C + N +P++ W+KD +PL D H
Sbjct: 2474 VLVPPHI-VGENTLEDVKVKEKQSVTLTC------EVTGNPVPEITWHKDGQPLQEDEAH 2526
Query: 174 FSGVKDRLI-VMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLEENKPTRPVIVSPA 232
R + + NV H G YTC AS + G + + F++ PT + S
Sbjct: 2527 HIISGGRFLQITNVQVPHTGRYTCLAS-SPAGHKSRSFSLNVFVS-----PTIAGVGSDG 2580
Query: 233 N-ETMEVDLGSQIQLICNVTGQLSDIAYWKWNGSVIDED 270
N E + V L S L+C W +G+ ++ +
Sbjct: 2581 NPEDVTVILNSPTSLVCEAYSYPPATITWFKDGTPLESN 2619
Score = 55.5 bits (132), Expect = 1e-07
Identities = 51/206 (24%), Positives = 88/206 (42%), Gaps = 30/206 (14%)
Query: 54 TITWYKDDSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSS------YCLRI 107
T+TWYKD P+++ I L AKVED+G Y CV N + Y +R+
Sbjct: 2808 TLTWYKDGH--PLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRV 2865
Query: 108 KISAKFVENEPNLCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKDCKPL 167
+ P + A + +++ V + + + + + P+ W KD +PL
Sbjct: 2866 LV--------PPIIKGANSDLPEEVTVLVNKSALIECL----SSGSPAPRNSWQKDGQPL 2913
Query: 168 LLDNIHFSGVKDRLI-VMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLEENKPTRP 226
L D+ H R++ ++N G Y C A T + ++ L + P P
Sbjct: 2914 LEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGSAK-------KYFNLNVHVP--P 2964
Query: 227 VIVSPANETMEVDLGSQIQLICNVTG 252
++ P +E + V + + I L C V+G
Sbjct: 2965 SVIGPKSENLTVVVNNFISLTCEVSG 2990
Score = 54.7 bits (130), Expect = 2e-07
Identities = 61/221 (27%), Positives = 92/221 (41%), Gaps = 24/221 (10%)
Query: 55 ITWYKDDSKTPVSTEQASRIHQHKEKLWFVP-AKVEDSGHYYCVVRNSSYCLRIKISAKF 113
ITWYKD +S+ QA ++ K + +P A+V DS Y C V N +
Sbjct: 1579 ITWYKDGQPI-MSSSQA--LYIDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHVD- 1634
Query: 114 VENEPNLCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKDCKPLLL-DNI 172
V P + N +++ +A L C K N P L W KD P+ DNI
Sbjct: 1635 VYVPPMIEGNLATPLNKQVVIAHSLTLEC------KAAGNPSPILTWLKDGVPVKANDNI 1688
Query: 173 HFSGVKDRLIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLEENKPTRPVIVSPA 232
+L +M+ E RG Y C A T + + I ++ + P +
Sbjct: 1689 RIEAGGKKLEIMSAQEIDRGQYICVA--TSVAGEKEIKYEVDVLV--------PPAIEGG 1738
Query: 233 NETME--VDLGSQIQLICNVTGQLSDIAYWKWNGSVIDEDD 271
+ET V + + ++L C+VTG W +G +IDE D
Sbjct: 1739 DETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLIDERD 1779
Score = 43.5 bits (101), Expect = 5e-04
Identities = 41/153 (26%), Positives = 67/153 (43%), Gaps = 17/153 (11%)
Query: 54 TITWYKDDSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSSYCL----RIKI 109
TITW+KD TP+ + + RI L + A+ +++G Y CV N + + +K+
Sbjct: 2606 TITWFKDG--TPLESNRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYEVKV 2663
Query: 110 SAKFVENEPNLCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELP--KLQWYKDCKPL 167
+ N+ +L + + K+ V L C E +P L WYKD +PL
Sbjct: 2664 YIPPIINKGDLWGPGLSPKEVKIKVNNTLTLEC--------EAYAIPSASLSWYKDGQPL 2715
Query: 168 LL-DNIHFSGVKDRLIVMNVAEKHRGNYTCHAS 199
D+++ + L + G YTC AS
Sbjct: 2716 KSDDHVNIAANGHTLQIKEAQISDTGRYTCVAS 2748
Score = 42.7 bits (99), Expect = 9e-04
Identities = 33/111 (29%), Positives = 50/111 (45%), Gaps = 11/111 (9%)
Query: 54 TITWYKDDSKTPVSTEQAS-RIHQHKEKLWFVPAKVEDSGHYYCVVRNSSYCLRIKISAK 112
+ITW KDD PV+T Q + +I L +ED+G Y CV N++ + I
Sbjct: 1857 SITWLKDDQ--PVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLH 1914
Query: 113 FVENEPNLCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKD 163
+EP +A + + + V+ L C K N +P + WYKD
Sbjct: 1915 V--HEPPSLEDAGKMLNETVLVSNPVQLEC------KAAGNPVPVITWYKD 1957
Score = 41.2 bits (95), Expect = 0.003
Identities = 72/305 (23%), Positives = 115/305 (37%), Gaps = 55/305 (18%)
Query: 54 TITWYKDDSKTPVST-EQASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSS------YCLR 106
++TW KD S PVS+ ++ L A++ D+G Y CV N++ LR
Sbjct: 2042 SLTWLKDGS--PVSSFSNGLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLR 2099
Query: 107 IKISAKFVENEPNLCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKDCKP 166
+ + + E N+ + Q + + + P P L W KD P
Sbjct: 2100 VYVPPNIMGEEQNV----SVLISQAVELLCQSDAIPP------------PTLTWLKDGHP 2143
Query: 167 LL-LDNIHFSGVKDRLIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLEENKPTR 225
LL + S + L + + + G YTC A+ GK V ++
Sbjct: 2144 LLKKPGLSISENRSVLKIEDAQVQDTGRYTCEAT-NVAGKTEKNYNVNIWV--------- 2193
Query: 226 PVIVSPANETMEVDL--GSQIQLICNVTGQLSDIAYWKWNGSVIDEDDPVLGEDYYSVEN 283
P + ++E ++ + G+ I L+C +G WK GS PVL + V
Sbjct: 2194 PPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGS------PVLTDSMGRVRI 2247
Query: 284 PANKRRSTLITVLNISEIESRFYKHPFTCFAKNTHG-IDAAYIQLIY---PVTNFQKHMI 339
+ R+ L IS I + ++C A N G Y +Y +TN H
Sbjct: 2248 LSGGRQ------LQIS-IAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPTITNSGSHPT 2300
Query: 340 GICVT 344
I VT
Sbjct: 2301 EIIVT 2305
Score = 41.2 bits (95), Expect = 0.003
Identities = 51/226 (22%), Positives = 78/226 (34%), Gaps = 32/226 (14%)
Query: 54 TITWYKDDSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSSYCLRIKISAKF 113
T+TW KD P+ + I L V D+G Y CV N + K
Sbjct: 2323 TVTWMKDGH--PLIKAKGVEILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLS- 2379
Query: 114 VENEPNLCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKDCKPLLLDN-I 172
V P++ N ++ + L C + LP + W+KD P+ L N +
Sbjct: 2380 VHAPPSIIGNHRSPENISVVEKNSVSLTC------EASGIPLPSITWFKDGWPVSLSNSV 2433
Query: 173 HFSGVKDRLIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLEENKPTRPVIVSPA 232
L +M + G YTC V+ EE K ++ P
Sbjct: 2434 RILSGGRMLRLMQTTMEDAGQYTC---------------VVRNAAGEERKIFGLSVLVPP 2478
Query: 233 N-------ETMEVDLGSQIQLICNVTGQLSDIAYWKWNGSVIDEDD 271
+ E ++V + L C VTG W +G + ED+
Sbjct: 2479 HIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDE 2524
Score = 40.8 bits (94), Expect = 0.003
Identities = 54/221 (24%), Positives = 81/221 (36%), Gaps = 32/221 (14%)
Query: 54 TITWYKDDSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSS------YCLRI 107
TI W K+ + S RI KL ++ DSG+Y C+ N Y L I
Sbjct: 3182 TIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSI 3241
Query: 108 KISAKFVENEPNLCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENN-ELPKLQWYKDCKP 166
++ P A+ + + + LVC N N P +QW KD KP
Sbjct: 3242 QV--------PPSVAGAEIPSDVSVLLGENVELVC-------NANGIPTPLIQWLKDGKP 3286
Query: 167 LL---LDNIHFSGVKDRLIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLEENKP 223
+ + I S L + G YTC A+ G++ I + ++T P
Sbjct: 3287 IASGETERIRVSANGSTLNIYGALTSDTGKYTCVAT-NPAGEEDRIFNLNVYVT-----P 3340
Query: 224 TRPVIVSPANETMEVDLGSQIQLICNVTGQLSDIAYWKWNG 264
T A + M + + + I + C TG W NG
Sbjct: 3341 TIRGNKDEAEKLMTL-VDTSINIECRATGTPPPQINWLKNG 3380
Score = 40.0 bits (92), Expect = 0.006
Identities = 56/251 (22%), Positives = 92/251 (36%), Gaps = 45/251 (17%)
Query: 55 ITWYKDDSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRN----SSYCLRIKIS 110
ITW+KD S Q + + P D+GHY C+ N SS ++ +
Sbjct: 4110 ITWHKDGRAIVESIRQRVLSSGSLQIAFVQPG---DAGHYTCMAANVAGSSSTSTKLTVH 4166
Query: 111 A----KFVENEPNLCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKDCKP 166
+ E + N+QAI LP DG P + W KD
Sbjct: 4167 VPPRIRSTEGHYTVNENSQAI----LPCVADG--------------IPTPAINWKKD--N 4206
Query: 167 LLLDNI---HFSGVKDRLIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLEENKP 223
+LL N+ + + LI+ NV + G YTC A+ + ++ + + P
Sbjct: 4207 VLLANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELP 4266
Query: 224 TRPVIVSPANETMEVDLGSQIQLICNVTGQLSDIAYWKWNGSVIDED-DPVLGEDYYSVE 282
+ ++ G Q++L C TG W +N ++I D V G +E
Sbjct: 4267 ----------GDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSELVIE 4316
Query: 283 NPANKRRSTLI 293
+ + T +
Sbjct: 4317 RVSKEDSGTYV 4327
Score = 37.4 bits (85), Expect = 0.037
Identities = 36/149 (24%), Positives = 59/149 (39%), Gaps = 15/149 (10%)
Query: 54 TITWYKDDSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSSYCLRIKISAKF 113
++ W +D P+ + + H L + A+ EDSG Y C+ N + ++S F
Sbjct: 3466 SMAWLRDGQ--PLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAG----EVSKHF 3519
Query: 114 VEN--EPNLCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKDCKPL-LLD 170
+ EP ++ + + V L C PK+ W KD +PL D
Sbjct: 3520 ILKVLEPPHINGSEEHEEISVIVNNPLELTCIASGI------PAPKMTWMKDGRPLPQTD 3573
Query: 171 NIHFSGVKDRLIVMNVAEKHRGNYTCHAS 199
+ G + L + + G YTC AS
Sbjct: 3574 QVQTLGGGEVLRISTAQVEDTGRYTCLAS 3602
Score = 37.0 bits (84), Expect = 0.049
Identities = 53/237 (22%), Positives = 84/237 (35%), Gaps = 38/237 (16%)
Query: 38 EIDVRPCPLNPNEHKGTITWYKDDSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCV 97
E++ P P+ I WYKD+ + V+ + + + L A ED+G Y C
Sbjct: 1383 EVEGTPSPI--------IMWYKDNVQ--VTESSTIQTVNNGKILKLFRATPEDAGRYSCK 1432
Query: 98 VRNSSYCLRIKISAKFVENE---PNLCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNE 154
N + S K+ + P + + + D L C +
Sbjct: 1433 AINIA-----GTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALECQV------KGTP 1481
Query: 155 LPKLQWYKDCKPLLL--DNIHFSGVKDRLIVMNVAEKHRGNYTCHASYTYLGKQYPITRV 212
P + W+KD KPL L N+ L + N +G Y C S GKQ ++
Sbjct: 1482 FPDIHWFKDGKPLFLGDPNVELLDRGQVLHLKNARRNDKGRYQCTVS-NAAGKQAKDIKL 1540
Query: 213 IEFITLEENKPTRPVIVSPANETMEVD--LGSQIQLICNVTGQLSDIAYWKWNGSVI 267
+I P + N T ++ + S I+L C G W +G I
Sbjct: 1541 TIYI---------PPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPI 1588
Score = 36.2 bits (82), Expect = 0.083
Identities = 63/255 (24%), Positives = 101/255 (39%), Gaps = 48/255 (18%)
Query: 25 EREEKIILVSSANEIDVRPCPLNPNEHKGTITWYKDDSKTPVSTEQASRIHQHKEKLWFV 84
E + +L+S A E+ + + P T+TW KD P+ + I +++ L
Sbjct: 2109 EEQNVSVLISQAVELLCQSDAIPPP----TLTWLKDGH--PLLKKPGLSISENRSVLKIE 2162
Query: 85 PAKVEDSGHYYCVVRN------SSYCLRIKISAKFVENEPNLCYNAQAIFKQKLPVAGDG 138
A+V+D+G Y C N +Y + I + PN+ + + +L V +G
Sbjct: 2163 DAQVQDTGRYTCEATNVAGKTEKNYNVNIWV-------PPNIGGSDEL---TQLTVI-EG 2211
Query: 139 GLVCPYMEFFKNENNELPKLQWYKDCKPLLLDNIH----FSGVKDRLIVMNVAEK-HRGN 193
L+ E + P L W K P+L D++ SG R + +++AEK
Sbjct: 2212 NLISLLCE---SSGIPPPNLIWKKKGSPVLTDSMGRVRILSG--GRQLQISIAEKSDAAL 2266
Query: 194 YTCHASYT--YLGKQYPITRVIEFITLEENKPTRPVIVSPANETME--VDLGSQIQLICN 249
Y+C AS K+Y + I RP I + + E V G I L C
Sbjct: 2267 YSCVASNVAGTAKKEYNLQVYI-----------RPTITNSGSHPTEIIVTRGKSISLECE 2315
Query: 250 VTGQLSDIAYWKWNG 264
V G W +G
Sbjct: 2316 VQGIPPPTVTWMKDG 2330
Score = 36.2 bits (82), Expect = 0.083
Identities = 59/285 (20%), Positives = 103/285 (36%), Gaps = 42/285 (14%)
Query: 54 TITWYKDDSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSS------YCLRI 107
+++WYKD P+ ++ I + L A++ D+G Y CV N + + + I
Sbjct: 2705 SLSWYKDGQ--PLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNI 2762
Query: 108 KISAKFVENEPNLCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKDCKPL 167
++ F L + + A D + P + + P L WYKD PL
Sbjct: 2763 QVPPSF----QKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPL 2818
Query: 168 L-LDNIHFSGVKDRLIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLEENKPTRP 226
D + L + + G YTC A + E + + P
Sbjct: 2819 TSSDKVLILPGGRVLQIPRAKVEDAGRYTCVA----------VNEAGEDSLQYDVRVLVP 2868
Query: 227 VIVSPAN----ETMEVDLGSQIQLICNVTGQLSDIAYWKWNGSVIDEDDPVLGEDYYSVE 282
I+ AN E + V + + C +G + W+ +G P+L +D++
Sbjct: 2869 PIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDG------QPLLEDDHHKFL 2922
Query: 283 NPANKRRSTLITVLNISEIESRFYKHPFTCFAKNTHGIDAAYIQL 327
+ ++ +LN + Y C A+NT G Y L
Sbjct: 2923 S-----NGRILQILNTQITDIGRY----VCVAENTAGSAKKYFNL 2958
Score = 35.8 bits (81), Expect = 0.11
Identities = 44/221 (19%), Positives = 80/221 (36%), Gaps = 24/221 (10%)
Query: 55 ITWYKDDSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSSYCLRIKISAKFV 114
++W K++ P+ + I L + AKV D G Y C+ N + + K S
Sbjct: 2996 LSWLKNEQ--PIKLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVY 3053
Query: 115 ENEPNLCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPK--LQWYKDCKPLLLDNI 172
++++++ + L C E+N +P + WYK+ + ++ ++
Sbjct: 3054 VPPSIKDHDSESLSVVNVREGTSVSLEC--------ESNAVPPPVITWYKNGR-MITEST 3104
Query: 173 HFSGVKD--RLIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLEENKPTRPVIVS 230
H + D L + G Y C A G+ + N P I
Sbjct: 3105 HVEILADGQMLHIKKAEVSDTGQYVCRA-INVAGR--------DDKNFHLNVYVPPSIEG 3155
Query: 231 PANETMEVDLGSQIQLICNVTGQLSDIAYWKWNGSVIDEDD 271
P E + + + + L C+ TG W N I+ D
Sbjct: 3156 PEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENSD 3196
Score = 35.8 bits (81), Expect = 0.11
Identities = 56/259 (21%), Positives = 97/259 (37%), Gaps = 41/259 (15%)
Query: 25 EREEKIILVSSANEIDVRPCPLNPNEHKGTITWYKDDSKTPVSTEQASRIHQHKEKLWFV 84
E E+ + LV ++ I+ R P + I W K+ P+S+ R+ + + V
Sbjct: 3348 EAEKLMTLVDTSINIECRATGTPPPQ----INWLKNGLPLPLSSH--IRLLAAGQVIRIV 3401
Query: 85 PAKVEDSGHYYCVVRNSSYCLRIKISAKFVENEPNLCYNAQAIFKQKLPVAGDGGLVCPY 144
A+V D Y CV N + N YN Q P D +
Sbjct: 3402 RAQVSDVAVYTCVASNRA-------------GVDNKHYNLQVF----APPNMDNSMGTEE 3444
Query: 145 MEFFKNENNEL---------PKLQWYKDCKPLLLD-NIHFSGVKDRLIVMNVAEKHRGNY 194
+ K + + P + W +D +PL LD ++ S L ++ + G Y
Sbjct: 3445 ITVLKGSSTSMACITDGTPAPSMAWLRDGQPLGLDAHLTVSTHGMVLQLLKAETEDSGKY 3504
Query: 195 TCHASYTYLGKQYPITRVIEFITLEENKPTRPVIVSPANETMEVDLGSQIQLICNVTGQL 254
TC AS V + L+ +P + S +E + V + + ++L C +G
Sbjct: 3505 TCIAS-------NEAGEVSKHFILKVLEPPH-INGSEEHEEISVIVNNPLELTCIASGIP 3556
Query: 255 SDIAYWKWNGSVIDEDDPV 273
+ W +G + + D V
Sbjct: 3557 APKMTWMKDGRPLPQTDQV 3575
Score = 35.0 bits (79), Expect = 0.18
Identities = 47/219 (21%), Positives = 76/219 (34%), Gaps = 31/219 (14%)
Query: 52 KGTITWYKDDSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRNS------SYCL 105
K +I W K+ V Q S L + V+D+ Y C V N + L
Sbjct: 3832 KPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGAGDDKRTVDL 3891
Query: 106 RIKISAKFVENEPNLCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKDCK 165
+++ + + A + G+ P + + KN LP+ Y+
Sbjct: 3892 TVQVPPSIADEPTDFLVTKHA---PAVITCTASGVPFPSIHWTKNGIRLLPRGDGYR--- 3945
Query: 166 PLLLDNIHFSGVKDRLIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLEENKPTR 225
I SG + ++ H G YTC A G + +TL ++P
Sbjct: 3946 ------ILSSGA---IEILATQLNHAGRYTCVAR-NAAGSAH------RHVTLHVHEPP- 3988
Query: 226 PVIVSPANETMEVDLGSQIQLICNVTGQLSDIAYWKWNG 264
++ P + V L + I L C TG S W+ G
Sbjct: 3989 --VIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEG 4025
Score = 31.6 bits (70), Expect = 2.0
Identities = 45/192 (23%), Positives = 65/192 (33%), Gaps = 42/192 (21%)
Query: 88 VEDSGHYYCVVRNS------SYCLRIKISAKFVENEPNLCYNAQAIFKQKLPVAGDGGLV 141
+EDSG Y CV N+ + L + + F E ++ N + L
Sbjct: 4231 LEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLR----------LS 4280
Query: 142 CPYMEFFKNENNELPKLQWYKDCKPLLLDNI---HFSGVK--DRLIVMNVAEKHRGNYTC 196
C K LPKL W +NI HF V L++ V+++ G Y C
Sbjct: 4281 C------KATGIPLPKLTW------TFNNNIIPAHFDSVNGHSELVIERVSKEDSGTYVC 4328
Query: 197 HASYTYLGKQYPITRVIEFITLEENKPTRPVIVSPANETMEVDLGSQIQLICNVTGQLSD 256
A + I F+ ++E PV LG L C V G +
Sbjct: 4329 TAE-----NSVGFVKAIGFVYVKE----PPVFKGDYPSNWIEPLGGNAILNCEVKGDPTP 4379
Query: 257 IAYWKWNGSVID 268
W G I+
Sbjct: 4380 TIQWNRKGVDIE 4391
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 53.5 bits (127), Expect = 5e-07
Identities = 66/279 (23%), Positives = 106/279 (37%), Gaps = 36/279 (12%)
Query: 55 ITWYKDDSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSSYCLRIKISAKFV 114
++WYK D+K +T + L F + DSG Y C NS +
Sbjct: 7992 VSWYKGDTKLRPTTTYKMHFRNNVATLVFNQVDINDSGEYICKAENSVGEVSASTFLTVQ 8051
Query: 115 ENEPNLCYNAQAIFKQK---LPVAGDGGLVCPYMEFFKNENNELPKLQWYKDCKPLLLDN 171
E + ++ Q Q+ LPV D + +E + WYKD KPL
Sbjct: 8052 EQKLPPSFSRQLRDVQETVGLPVVFDCAI----------SGSEPISVSWYKDGKPLKDSP 8101
Query: 172 IHFSGVKDRLIVMNVAEKHR---GNYTCHASYTYLGKQYPITRVIEFITLEENKPTRPVI 228
+ D +N+ + R G Y+C A+ +G R+I +T +N P +
Sbjct: 8102 NVQTSFLDNTATLNIFKTDRSLAGQYSCTAT-NPIGSASSSARLI--LTEGKNPPFFDIR 8158
Query: 229 VSPANETMEVDLGSQIQLICNVTGQLSDIAYWKWNGSVIDEDDPVLGEDYYSVENPANKR 288
++P ++ +G C+VTG W + + Y + N
Sbjct: 8159 LAP----VDAVVGESADFECHVTGTQPIKVSW------AKDSREIRSGGKYQISYLEN-- 8206
Query: 289 RSTLITVLNISEIESRFYKHPFTCFAKNTHGIDAAYIQL 327
S +TVL + + +S Y TC+A N G D+ QL
Sbjct: 8207 -SAHLTVLKVDKGDSGQY----TCYAVNEVGKDSCTAQL 8240
Score = 43.5 bits (101), Expect = 5e-04
Identities = 48/206 (23%), Positives = 76/206 (36%), Gaps = 25/206 (12%)
Query: 54 TITWYKDDSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSSYCLRIKISAKF 113
T++WYK D+K + E + + L F + DSG Y C NS K +
Sbjct: 6109 TVSWYKGDTKLRPTPEYRTYFTNNVATLVFNKVNINDSGEYTCKAENSIGTASSKTVFRI 6168
Query: 114 VENE--PNLCYNAQAIFKQ-KLPVAGDGGLVCPYMEFFKNENNELP-KLQWYKDCKPLLL 169
E + P+ + I + LPV L C N P ++ WY+D L
Sbjct: 6169 QERQLPPSFARQLKDIEQTVGLPVT----LTC-------RLNGSAPIQVCWYRDGVLLRD 6217
Query: 170 DNIHFSGVKDRLIVMNVAE---KHRGNYTCHASYTYLGKQYPITRVIEFITLEENKPTRP 226
D + D + + + + H G Y+C AS P+ L +P +
Sbjct: 6218 DENLQTSFVDNVATLKILQTDLSHSGQYSCSAS-------NPLGTASSSARLTAREPKKS 6270
Query: 227 VIVSPANETMEVDLGSQIQLICNVTG 252
+++V G C+VTG
Sbjct: 6271 PFFDIKPVSIDVIAGESADFECHVTG 6296
Score = 39.7 bits (91), Expect = 0.008
Identities = 41/156 (26%), Positives = 65/156 (41%), Gaps = 20/156 (12%)
Query: 50 EHKGTITWYKDDSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRN---SSYCLR 106
+ K T+TW KD K P + L AK++DSG Y C N SS C
Sbjct: 3670 DRKVTVTWSKDGQKLPPGKDYKICFEDKIATLEIPLAKLKDSGTYVCTASNEAGSSSC-- 3727
Query: 107 IKISAKFVENEPNLCYNAQAIFKQKLPVAGDGG-LVCPYMEFFKNENNELPKLQWYKDCK 165
SA EP + + L + G+ L C K + + + ++ W+K+ K
Sbjct: 3728 ---SATVTVREPPSF--VKKVDPSYLMLPGESARLHC------KLKGSPVIQVTWFKNNK 3776
Query: 166 PLLLDN---IHFSGVKDRLIVMNVAEKHRGNYTCHA 198
L N ++F + L + +V + G+Y+C A
Sbjct: 3777 ELSESNTVRMYFVNSEAILDITDVKVEDSGSYSCEA 3812
Score = 37.4 bits (85), Expect = 0.037
Identities = 62/279 (22%), Positives = 111/279 (39%), Gaps = 35/279 (12%)
Query: 54 TITWYKDDSKTPVSTEQASRIHQHKEKLWFVPAK-VEDSGHYYCVVRNSSYCLRIKISAK 112
++TW K+ S ++ + K + +P+ VED+G Y C + N+S + SA+
Sbjct: 7898 SVTWKKNGINVTPS-QRCNITTTEKSAILEIPSSTVEDAGQYNCYIENASG--KDSCSAQ 7954
Query: 113 FVENEPNLCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYK---DCKPLLL 169
+ EP Y + + K+ V L C + + WYK +P
Sbjct: 7955 ILILEPP--YFVKQLEPVKVSVGDSASLQC------QLAGTPEIGVSWYKGDTKLRPTTT 8006
Query: 170 DNIHFSGVKDRLIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLEENKPTRPVIV 229
+HF L+ V G Y C A + +G+ T F+T++E K P
Sbjct: 8007 YKMHFRNNVATLVFNQVDINDSGEYICKAENS-VGEVSAST----FLTVQEQK--LPPSF 8059
Query: 230 SPANETMEVDLGSQIQLICNVTGQLSDIAYWKWNGSVIDEDDPVLGEDYYSVENPANKRR 289
S ++ +G + C ++G W +G + +D P + + ++N A
Sbjct: 8060 SRQLRDVQETVGLPVVFDCAISGSEPISVSWYKDGKPL-KDSPNVQTSF--LDNTA---- 8112
Query: 290 STLITVLNISEIESRFYKHPFTCFAKNTHGIDAAYIQLI 328
LNI + + R ++C A N G ++ +LI
Sbjct: 8113 -----TLNIFKTD-RSLAGQYSCTATNPIGSASSSARLI 8145
Score = 37.0 bits (84), Expect = 0.049
Identities = 51/217 (23%), Positives = 78/217 (35%), Gaps = 31/217 (14%)
Query: 55 ITWYKDDSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRN---SSYCLRIKISA 111
ITW+KD++ + + I H L + D+G Y C V N SS C SA
Sbjct: 4424 ITWFKDNTILRSGRKYKTFIQDHLVSLQILKFVAADAGEYQCRVTNEVGSSIC-----SA 4478
Query: 112 KFVENEPNLCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELP-KLQWYKDCKPLLLD 170
+ EP I K + + GG F LP + W KD + D
Sbjct: 4479 RVTLREP-----PSFIKKIESTSSLRGGTAA----FQATLKGSLPITVTWLKDSDEITED 4529
Query: 171 N---IHFSGVKDRLIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLEENKPTRPV 227
+ + F L + + KH G Y C A I R ++++E P
Sbjct: 4530 DNIRMTFENNVASLYLSGIEVKHDGKYVCQAK-----NDAGIQRCSALLSVKE-----PA 4579
Query: 228 IVSPANETMEVDLGSQIQLICNVTGQLSDIAYWKWNG 264
++ +++V G L +G A W +G
Sbjct: 4580 TITEEAVSIDVTQGDPATLQVKFSGTKEITAKWFKDG 4616
Score = 36.6 bits (83), Expect = 0.064
Identities = 70/309 (22%), Positives = 113/309 (36%), Gaps = 46/309 (14%)
Query: 55 ITWYKDDSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSSYCLRIKISAKFV 114
+ WYKD+++ S++ L VEDSG Y C N++ S K V
Sbjct: 7337 VLWYKDETEIQESSKFRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGSASSSTSLK-V 7395
Query: 115 ENEPNLCYNAQAIFKQKLPVAGDGGLVC------PYMEFFKNENNELPKLQWYKDCKPLL 168
+ P I K D L C P+ + + EL + YK
Sbjct: 7396 KEPPIFRKKPHPIETLK---GADVHLECELQGTPPFHVSWYKDKRELRSGKKYKIMSENF 7452
Query: 169 LDNIHFSGVKDRLIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLEENKPTRPVI 228
L +IH ++NV G Y C A+ + I L+ P
Sbjct: 7453 LTSIH---------ILNVDAADIGEYQCKAT-----NDVGSDTCVGSIALK----APPRF 7494
Query: 229 VSPANETMEVDLGSQIQLICNVTG-QLSDIAYWKWNGSVIDEDDPVLGEDYYSVENPANK 287
V ++ V +G ++QL + G + + ++K G ++ E D + YS EN
Sbjct: 7495 VKKLSDISTV-VGKEVQLQTTIEGAEPISVVWFKDKGEIVRESDNIWIS--YS-EN---- 7546
Query: 288 RRSTLITVLNISEIESRFYKHPFTCFAKNTHGIDAAY--IQLIYPVTNFQK-HMIGICVT 344
I L S +E +TC KN G+ + + ++ P T +K I +
Sbjct: 7547 -----IATLQFSRVEPA-NAGKYTCQIKNDAGMQECFATLSVLEPATIVEKPESIKVTTG 7600
Query: 345 LTVIIVCSV 353
T + C+V
Sbjct: 7601 DTCTLECTV 7609
Score = 33.5 bits (75), Expect = 0.54
Identities = 64/288 (22%), Positives = 104/288 (36%), Gaps = 48/288 (16%)
Query: 55 ITWYKDDSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRN---SSYCLRIKISA 111
ITW+ +D + S++ + L +EDSG Y C +N S +C I I
Sbjct: 4331 ITWFANDREIKESSKHRMSFVESTAVLRLTDVGIEDSGEYMCEAQNEAGSDHCSSIVI-- 4388
Query: 112 KFVENEPNLCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELP--KLQWYKDCKPLLL 169
V+ P K+ P+ ++ Y E P ++ W+KD L
Sbjct: 4389 --VKESPYFT-------KEFKPIE----VLKEYDVMLLAEVAGTPPFEITWFKDNTILRS 4435
Query: 170 DNIHFSGVKDRLI---VMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLEENKPTRP 226
+ + ++D L+ ++ G Y C + +G RV TL E P
Sbjct: 4436 GRKYKTFIQDHLVSLQILKFVAADAGEYQCRVT-NEVGSSICSARV----TLRE----PP 4486
Query: 227 VIVSPANETMEVDLGSQIQLICNVTGQLSDIAYWKWNGSVIDEDDPVLGEDYYSVENPAN 286
+ T + G + G L W + I EDD + + EN
Sbjct: 4487 SFIKKIESTSSL-RGGTAAFQATLKGSLPITVTWLKDSDEITEDDNI----RMTFENN-- 4539
Query: 287 KRRSTLITVLNISEIESRFYKHPFTCFAKNTHGID--AAYIQLIYPVT 332
+ L +S IE + + + C AKN GI +A + + P T
Sbjct: 4540 ------VASLYLSGIEVK-HDGKYVCQAKNDAGIQRCSALLSVKEPAT 4580
Score = 33.5 bits (75), Expect = 0.54
Identities = 28/119 (23%), Positives = 43/119 (36%), Gaps = 6/119 (5%)
Query: 51 HKGTITWYKDDSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRNS------SYC 104
H +I W+KDD + S + H + L + DSG Y C N S
Sbjct: 4702 HPISIQWFKDDQEISASEKYKFSFHDNTAFLEISQLEGTDSGTYTCSATNKAGHNQCSGH 4761
Query: 105 LRIKISAKFVENEPNLCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKD 163
L +K FVE + N + K V G + + + K ++ + W D
Sbjct: 4762 LTVKEPPYFVEKPQSQDVNPNTRVQLKALVGGTAPMTIKWFKDNKELHSGAARSVWKDD 4820
Score = 33.1 bits (74), Expect = 0.70
Identities = 61/280 (21%), Positives = 95/280 (33%), Gaps = 42/280 (15%)
Query: 55 ITWYKDDSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSSYCLRIKISAKFV 114
++WY D ++ + A+VE+SG Y C RN + I K V
Sbjct: 4893 VSWYLDGNEITAIQKHGISFIDGLATFQISGARVENSGTYVCEARNDAGTASCSIELK-V 4951
Query: 115 ENEPNLCYNAQAIFKQKLPVAGDGGLVC------PYMEFFKNENNELPKLQWYKDCKPLL 168
+ P + + K D L C P+ + N E+ + Y +
Sbjct: 4952 KEPPTFIRELKPVEVVKY---SDVELECEVTGTPPFEVTWLKNNREIRSSKKYTLTDRVS 5008
Query: 169 LDNIHFSGVKDRLIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLEENKPTRPVI 228
+ N+H + G Y C S G TRV L+E P
Sbjct: 5009 VFNLH---------ITKCDPSDTGEYQCIVS-NEGGSCSCSTRV----ALKE----PPSF 5050
Query: 229 VSPANETMEVDLGSQIQLICNVTGQLSDIAYWKWNGSVIDEDDPVLGEDYYSVENPANKR 288
+ T V L S V G W + ++DEDD V Y S +
Sbjct: 5051 IKKIENTTTV-LKSSATFQSTVAGSPPISITWLKDDQILDEDDNV----YISFVDS---- 5101
Query: 289 RSTLITVLNISEIESRFYKHPFTCFAKNTHGIDAAYIQLI 328
+ L I +++ + +TC AKN G++ Y L+
Sbjct: 5102 ----VATLQIRSVDNG-HSGRYTCQAKNESGVERCYAFLL 5136
Score = 32.7 bits (73), Expect = 0.92
Identities = 18/68 (26%), Positives = 29/68 (42%), Gaps = 2/68 (2%)
Query: 44 CPLNPNEHKGTITWYKDDSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSSY 103
C + + KG W +D P++ S HK +L K++D G Y V S
Sbjct: 2641 CEVANPDSKGE--WLRDGKHLPLTNNIRSESDGHKRRLIIAATKLDDIGEYTYKVATSKT 2698
Query: 104 CLRIKISA 111
++K+ A
Sbjct: 2699 SAKLKVEA 2706
Score = 31.2 bits (69), Expect = 2.7
Identities = 46/218 (21%), Positives = 75/218 (34%), Gaps = 22/218 (10%)
Query: 55 ITWYKDDSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSSYCLRIKISAKFV 114
++W+KD + S + L + + D+G++ C N S + A V
Sbjct: 4144 VSWFKDGKEIAASDRYRIAFVEGTASLEIIRVDMNDAGNFTCRATN-SVGSKDSSGALIV 4202
Query: 115 ENEPNLCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKDCKPLLLDN--- 171
+ P+ + K LP G VC F + + ++W+K K L+
Sbjct: 4203 QEPPSFVTKPGS--KDVLP----GSAVCLKSTF---QGSTPLTIRWFKGNKELVSGGSCY 4253
Query: 172 IHFSGVKDRLIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLEENKPTRPVIVSP 231
I ++ L + V G YTC S G + ++ +P V
Sbjct: 4254 ITKEALESSLELYLVKTSDSGTYTCKVSNVAGGVECSANLFVK-------EPA--TFVEK 4304
Query: 232 ANETMEVDLGSQIQLICNVTGQLSDIAYWKWNGSVIDE 269
+ + G QL C VTG W N I E
Sbjct: 4305 LEPSQLLKKGDATQLACKVTGTPPIKITWFANDREIKE 4342
Score = 30.8 bits (68), Expect = 3.5
Identities = 38/185 (20%), Positives = 74/185 (40%), Gaps = 27/185 (14%)
Query: 54 TITWYKDDSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSSYCLRIKISAKF 113
T+ W KDD + ++ + ++ +L ++ D+G Y V + ++ + +
Sbjct: 3087 TVQWMKDDQELQITDRIKIQKEKYVHRLLIPSTRMSDAGKYTVVAGGNVSTAKLFVEGRD 3146
Query: 114 VENEPNLCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKDCKPL--LLDN 171
V ++ Q I KQ+ V EF NE++ WYKD + +
Sbjct: 3147 VRIR-SIKKEVQVIEKQRAVV-----------EFEVNEDD--VDAHWYKDGIEINFQVQE 3192
Query: 172 IHFSGVKDRLIVMNVAEKHR---GNYTCHAS--------YTYLGKQYPITRVIEFITLEE 220
H V+ R+ M ++E + G YT A Y + + + ++ +T++
Sbjct: 3193 RHKYVVERRIHRMFISETRQSDAGEYTFVAGRNRSSVTLYVNAPEPPQVLQELQPVTVQS 3252
Query: 221 NKPTR 225
KP R
Sbjct: 3253 GKPAR 3257
Score = 30.4 bits (67), Expect = 4.6
Identities = 54/235 (22%), Positives = 76/235 (32%), Gaps = 26/235 (11%)
Query: 54 TITWYKDDSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSSYCLRIKISAKF 113
TI W+KD+ + ++ L AK DSG Y C + N K + F
Sbjct: 4798 TIKWFKDNKELHSGAARSVWKDDTSTSLELFAAKATDSGTYICQLSNDVGTATSK-ATLF 4856
Query: 114 VENEPNLCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQ--WYKDCKPLLLDN 171
V+ P K+ PV L F+ + PK++ WY D +
Sbjct: 4857 VKEPPQ-------FIKKPSPVL---VLRNGQSTTFECQITGTPKIRVSWYLDGNEITAIQ 4906
Query: 172 IHFSGVKDRLIVMNVA---EKHRGNYTCHASYTYLGKQYPITRVIEFITLEENKPTRPVI 228
H D L ++ ++ G Y C A I E K P
Sbjct: 4907 KHGISFIDGLATFQISGARVENSGTYVCEARNDAGTASCSI----------ELKVKEPPT 4956
Query: 229 VSPANETMEVDLGSQIQLICNVTGQLSDIAYWKWNGSVIDEDDPVLGEDYYSVEN 283
+ +EV S ++L C VTG W N I D SV N
Sbjct: 4957 FIRELKPVEVVKYSDVELECEVTGTPPFEVTWLKNNREIRSSKKYTLTDRVSVFN 5011
Score = 30.4 bits (67), Expect = 4.6
Identities = 48/226 (21%), Positives = 84/226 (37%), Gaps = 38/226 (16%)
Query: 54 TITWYKDDSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGH---YYCVVRNSSYCLR---- 106
+ITW KDD + E + + + + + D+GH Y C +N S R
Sbjct: 5078 SITWLKDDQ---ILDEDDNVYISFVDSVATLQIRSVDNGHSGRYTCQAKNESGVERCYAF 5134
Query: 107 --IKISAKFVENEPNLCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKDC 164
++ A+ VE ++ + + VAG L K++W KD
Sbjct: 5135 LLVQEPAQIVEKAKSVDVTEKDPMTLECVVAGTPEL----------------KVKWLKDG 5178
Query: 165 KPLLLDNIHFSGVKDRLI---VMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLEEN 221
K ++ ++ + + +V ++ G YT + + L++N
Sbjct: 5179 KQIVPSRYFSMSFENNVASFRIQSVMKQDSGQYTFKVENDFGSSSCDAYLRV----LDQN 5234
Query: 222 KPTRPVIVSPANETMEVDLGSQIQLICNVTGQLSDIAYWKWNGSVI 267
P P + M+ LGS I + C V+G L A W +G I
Sbjct: 5235 IP--PSFTKKLTK-MDKVLGSSIHMECKVSGSLPISAQWFKDGKEI 5277
Score = 30.0 bits (66), Expect = 5.9
Identities = 18/66 (27%), Positives = 30/66 (45%), Gaps = 6/66 (9%)
Query: 54 TITWYKDDSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRN------SSYCLRI 107
T+TWY++D + S + +L A EDSG + C N +S L +
Sbjct: 973 TVTWYREDYQIESSIDFQITFQSGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAV 1032
Query: 108 KISAKF 113
++S +F
Sbjct: 1033 QVSEEF 1038
Score = 30.0 bits (66), Expect = 5.9
Identities = 47/196 (23%), Positives = 80/196 (40%), Gaps = 27/196 (13%)
Query: 7 LICFIALLISSLE-ADKCKEREEKIILVSS--ANEIDVRPCPLNPNEHKGTITWYKDDSK 63
L+ FI +S E K+ E + +L + EID++ +N E K ++WYK K
Sbjct: 8642 LVSFIQQRLSQTEPVTLIKDIENQTVLKDNDAVFEIDIK---INYPEIK--LSWYKGTEK 8696
Query: 64 TPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSSYCLRIKISAKFVENEPNLCYN 123
S + I + L +++D G+Y V C SAK EP +
Sbjct: 8697 LEPSDKFEISIDGDRHTLRVKNCQLKDQGNYRLV------CGPHIASAKLTVIEPAWERH 8750
Query: 124 AQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKDCKPLLLDNIHFSGVK---DR 180
Q + ++ G C F N K +W+++ + L H + V+ +
Sbjct: 8751 LQDVTLKE-------GQTCTMTCQFSVPN---VKSEWFRNGRILKPQGRHKTEVEHKVHK 8800
Query: 181 LIVMNVAEKHRGNYTC 196
L + +V + +G YTC
Sbjct: 8801 LTIADVRAEDQGQYTC 8816
Score = 29.6 bits (65), Expect = 7.8
Identities = 31/145 (21%), Positives = 52/145 (35%), Gaps = 13/145 (8%)
Query: 54 TITWYKDDSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSSYCLRIKISAKF 113
T+TW KD + + L+ +V+ G Y C +N + R SA
Sbjct: 4516 TVTWLKDSDEITEDDNIRMTFENNVASLYLSGIEVKHDGKYVCQAKNDAGIQR--CSALL 4573
Query: 114 VENEPNLCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKDCKPLLLDNIH 173
EP I ++ + + G F K W+KD + L L + +
Sbjct: 4574 SVKEP------ATITEEAVSIDVTQGDPATLQVKFSGTKEITAK--WFKDGQELTLGSKY 4625
Query: 174 FSGVKDRLIVMNV---AEKHRGNYT 195
V D + ++ + +K G YT
Sbjct: 4626 KISVTDTVSILKIISTEKKDSGEYT 4650
>gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo
sapiens]
Length = 1386
Score = 53.1 bits (126), Expect = 7e-07
Identities = 67/273 (24%), Positives = 103/273 (37%), Gaps = 41/273 (15%)
Query: 55 ITWYKDDSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSSYCLRIKISAKFV 114
+ W K+D + P + H LW ED G Y CV NS R + S
Sbjct: 289 LRWRKEDGELPTGRYEIRSDHS----LWIGHVSAEDEGTYTCVAENSVG--RAEASGSLS 342
Query: 115 ENEPNLCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKDCKPLLLDNIHF 174
+ P Q + + + +A G V E + N P + W K+ +LL
Sbjct: 343 VHVP-----PQLVTQPQDQMAAPGESVAFQCE---TKGNPPPAIFWQKEGSQVLLFPSQS 394
Query: 175 SGVKDRLIV-----MNVAEKHRGN---YTCHASYTYLGKQYPITRVIEFITLEENKPTRP 226
R V +N+ RG+ Y C A I+ +L+ P
Sbjct: 395 LQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPV-- 452
Query: 227 VIVSPANETMEVDLGSQIQLICNVTGQLSDIAYWKWNGSVIDEDDPVLGEDYYSVENPAN 286
++ PAN+T+ LGS + L C VTG WK +G + DD + AN
Sbjct: 453 ILQGPANQTLV--LGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDD-------LQFKTMAN 503
Query: 287 KRRSTLITVLNISEIESRFYKHPFTCFAKNTHG 319
+ + N+ E++ FY +C AK++ G
Sbjct: 504 ----GTLYIANVQEMDMGFY----SCVAKSSTG 528
Score = 30.0 bits (66), Expect = 5.9
Identities = 47/236 (19%), Positives = 82/236 (34%), Gaps = 23/236 (9%)
Query: 32 LVSSANEIDVRPCPLNPNEHKGTITWYKDDSKTPVSTEQASRIHQHKEKLWFVPAKVEDS 91
+V + E V C + +++W KD ++ E+ RI KL D+
Sbjct: 175 VVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLK---EEEGRITIRGGKLMMSHTLKSDA 231
Query: 92 GHYYCVVRNSSYCLRIKISAKFVENEPNLCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNE 151
G Y CV N + + V P+ + PV P + +
Sbjct: 232 GMYVCVASNMAGERESAAAEVMVLERPSFL---------RRPVNQVVLADAPVTFLCEVK 282
Query: 152 NNELPKLQWYKDCKPLLLDNIHFSGVKDRLIVMNVAEKHRGNYTCHASYTYLGKQYPITR 211
+ P+L+W K+ L L + +V+ + G YTC A + + R
Sbjct: 283 GDPPPRLRWRKEDGELPTGRYEIRS-DHSLWIGHVSAEDEGTYTCVA-------ENSVGR 334
Query: 212 VIEFITLEENKPTRPVIVSPANETMEVDLGSQIQLICNVTGQLSDIAYWKWNGSVI 267
+L + P P +V+ + M G + C G +W+ GS +
Sbjct: 335 AEASGSLSVHVP--PQLVTQPQDQMAAP-GESVAFQCETKGNPPPAIFWQKEGSQV 387
>gi|81158226 neuronal cell adhesion molecule isoform A precursor
[Homo sapiens]
Length = 1304
Score = 52.8 bits (125), Expect = 9e-07
Identities = 70/271 (25%), Positives = 111/271 (40%), Gaps = 44/271 (16%)
Query: 55 ITWYKDDSKTPVSTEQASRIHQHKEK-LWFVPAKVEDSGHYYCVVRNSSYCLRIKISAKF 113
I W K+D P + ++++ EK L + DSG+Y C+ +N+ + IS +
Sbjct: 302 IYWAKEDGMLPKNRT----VYKNFEKTLQIIHVSEADSGNYQCIAKNALGAIHHTISVR- 356
Query: 114 VENEPNLCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKDCKPLLL--DN 171
V+ P Y A L DG L+C + N P++ W + P+ + D+
Sbjct: 357 VKAAP---YWITAPQNLVLSPGEDGTLIC------RANGNPKPRISWLTNGVPIEIAPDD 407
Query: 172 IHFSGVKDRLIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLEENKPTRPVIVSP 231
D +I NV E+ Y C+AS Y Y + + E P I++P
Sbjct: 408 PSRKIDGDTIIFSNVQERSSAVYQCNASNEY---GYLLANAFVNVLAEP-----PRILTP 459
Query: 232 ANETMEVDLGSQIQLICNVTGQ-LSDIAYWKW-NGSVIDEDDPVLGEDYYSVENPANKRR 289
AN +V L C G L I ++K GS + ED VL E+ ++E P ++
Sbjct: 460 ANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALHEDIYVLHEN-GTLEIPVAQKD 518
Query: 290 STLITVLNISEIESRFYKHPFTCFAKNTHGI 320
ST +TC A+N G+
Sbjct: 519 ST----------------GTYTCVARNKLGM 533
Score = 37.7 bits (86), Expect = 0.029
Identities = 41/155 (26%), Positives = 64/155 (41%), Gaps = 25/155 (16%)
Query: 54 TITWYKDDSKTPVSTEQASRIHQ-----HKEKLWFVPAKVEDS-GHYYCVVRNSSYCLRI 107
TI W+K + S +H+ H+ +P +DS G Y CV RN
Sbjct: 485 TIEWFKG--------AKGSALHEDIYVLHENGTLEIPVAQKDSTGTYTCVARNK------ 530
Query: 108 KISAKFVENEPNL-CYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKDCKP 166
+NE +L + I KQ G + + K+++ + W KD +
Sbjct: 531 ---LGMAKNEVHLEIKDPTWIVKQPEYAVVQRGSMVSFECKVKHDHTLSLTVLWLKDNRE 587
Query: 167 LLLDNIHFSGVKDRLIVMNVAEKHRGNYTCHASYT 201
L D F+ KD L+V +V++ G YTC A+ T
Sbjct: 588 LPSDE-RFTVDKDHLVVADVSDDDSGTYTCVANTT 621
Score = 34.3 bits (77), Expect = 0.32
Identities = 38/168 (22%), Positives = 64/168 (38%), Gaps = 32/168 (19%)
Query: 156 PKLQWYKDCKPLLLDNIHFSGVKDRLIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIE- 214
P + W K+ L + + + L +++V+E GNY C A + I+ ++
Sbjct: 300 PIIYWAKEDGMLPKNRTVYKNFEKTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVKA 359
Query: 215 ---FITLEENKPTRPVIVSPANETMEVDLGSQIQLICNVTGQLSDIAYWKWNGSVIDEDD 271
+IT +N +++SP G LIC G W NG I+
Sbjct: 360 APYWITAPQN-----LVLSP---------GEDGTLICRANGNPKPRISWLTNGVPIE--- 402
Query: 272 PVLGEDYYSVENPANKRRSTLITVLNISEIESRFYKHPFTCFAKNTHG 319
+ ++P+ K I N+ E S Y+ C A N +G
Sbjct: 403 -------IAPDDPSRKIDGDTIIFSNVQERSSAVYQ----CNASNEYG 439
>gi|81158224 neuronal cell adhesion molecule isoform B precursor
[Homo sapiens]
Length = 1183
Score = 52.8 bits (125), Expect = 9e-07
Identities = 70/271 (25%), Positives = 111/271 (40%), Gaps = 44/271 (16%)
Query: 55 ITWYKDDSKTPVSTEQASRIHQHKEK-LWFVPAKVEDSGHYYCVVRNSSYCLRIKISAKF 113
I W K+D P + ++++ EK L + DSG+Y C+ +N+ + IS +
Sbjct: 296 IYWAKEDGMLPKNRT----VYKNFEKTLQIIHVSEADSGNYQCIAKNALGAIHHTISVR- 350
Query: 114 VENEPNLCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKDCKPLLL--DN 171
V+ P Y A L DG L+C + N P++ W + P+ + D+
Sbjct: 351 VKAAP---YWITAPQNLVLSPGEDGTLIC------RANGNPKPRISWLTNGVPIEIAPDD 401
Query: 172 IHFSGVKDRLIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLEENKPTRPVIVSP 231
D +I NV E+ Y C+AS Y Y + + E P I++P
Sbjct: 402 PSRKIDGDTIIFSNVQERSSAVYQCNASNEY---GYLLANAFVNVLAEP-----PRILTP 453
Query: 232 ANETMEVDLGSQIQLICNVTGQ-LSDIAYWKW-NGSVIDEDDPVLGEDYYSVENPANKRR 289
AN +V L C G L I ++K GS + ED VL E+ ++E P ++
Sbjct: 454 ANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALHEDIYVLHEN-GTLEIPVAQKD 512
Query: 290 STLITVLNISEIESRFYKHPFTCFAKNTHGI 320
ST +TC A+N G+
Sbjct: 513 ST----------------GTYTCVARNKLGM 527
Score = 37.7 bits (86), Expect = 0.029
Identities = 41/155 (26%), Positives = 64/155 (41%), Gaps = 25/155 (16%)
Query: 54 TITWYKDDSKTPVSTEQASRIHQ-----HKEKLWFVPAKVEDS-GHYYCVVRNSSYCLRI 107
TI W+K + S +H+ H+ +P +DS G Y CV RN
Sbjct: 479 TIEWFKG--------AKGSALHEDIYVLHENGTLEIPVAQKDSTGTYTCVARNK------ 524
Query: 108 KISAKFVENEPNL-CYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKDCKP 166
+NE +L + I KQ G + + K+++ + W KD +
Sbjct: 525 ---LGMAKNEVHLEIKDPTWIVKQPEYAVVQRGSMVSFECKVKHDHTLSLTVLWLKDNRE 581
Query: 167 LLLDNIHFSGVKDRLIVMNVAEKHRGNYTCHASYT 201
L D F+ KD L+V +V++ G YTC A+ T
Sbjct: 582 LPSDE-RFTVDKDHLVVADVSDDDSGTYTCVANTT 615
Score = 34.3 bits (77), Expect = 0.32
Identities = 38/168 (22%), Positives = 64/168 (38%), Gaps = 32/168 (19%)
Query: 156 PKLQWYKDCKPLLLDNIHFSGVKDRLIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIE- 214
P + W K+ L + + + L +++V+E GNY C A + I+ ++
Sbjct: 294 PIIYWAKEDGMLPKNRTVYKNFEKTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVKA 353
Query: 215 ---FITLEENKPTRPVIVSPANETMEVDLGSQIQLICNVTGQLSDIAYWKWNGSVIDEDD 271
+IT +N +++SP G LIC G W NG I+
Sbjct: 354 APYWITAPQN-----LVLSP---------GEDGTLICRANGNPKPRISWLTNGVPIE--- 396
Query: 272 PVLGEDYYSVENPANKRRSTLITVLNISEIESRFYKHPFTCFAKNTHG 319
+ ++P+ K I N+ E S Y+ C A N +G
Sbjct: 397 -------IAPDDPSRKIDGDTIIFSNVQERSSAVYQ----CNASNEYG 433
>gi|47524177 fibroblast growth factor receptor 4 isoform 2 precursor
[Homo sapiens]
Length = 762
Score = 52.0 bits (123), Expect = 1e-06
Identities = 79/354 (22%), Positives = 132/354 (37%), Gaps = 94/354 (26%)
Query: 30 IILVSSANEIDVRPC---PLNPNEHKGTIT-----------------WYKDDSKTPVSTE 69
++ + ++ E+++ PC L E + T+ WYK+ S+
Sbjct: 19 VLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRAERGGHWYKEGSRLA---- 74
Query: 70 QASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSSYCLRI-------KISAKFVENEPNL-- 120
A R+ + +L ED+G Y C+ R S L+ +++ + +P
Sbjct: 75 PAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDEDPKSHR 134
Query: 121 ------CYNAQAIF-------KQKLPVAGDGGLV---CPYMEFFKNENNELPKLQWYKDC 164
Y QA + ++KL G V CP N P ++W KD
Sbjct: 135 DPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAA------GNPTPTIRWLKDG 188
Query: 165 KPLLLDNIHFSGVKDR-----LIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLE 219
+ +N G++ R L++ +V RG YTC +Y + +
Sbjct: 189 QAFHGEN-RIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNY-----LLDVL 242
Query: 220 ENKPTRPVIVS--PANETMEVDLGSQIQLICNVTGQLSDIAYW----KWNGSVIDEDDPV 273
E P RP++ + PAN T V GS ++L+C V W NGS D
Sbjct: 243 ERSPHRPILQAGLPANTTAVV--GSDVELLCKVYSDAQPHIQWLKHIVINGSSFGAD--- 297
Query: 274 LGEDYYSVENPANKRRSTLITVLNISEIESRFYKH-------PFTCFAKNTHGI 320
G Y V A+ +N SE+E + ++ +TC A N+ G+
Sbjct: 298 -GFPYVQVLKTAD---------INSSEVEVLYLRNVSAEDAGEYTCLAGNSIGL 341
>gi|47524175 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 52.0 bits (123), Expect = 1e-06
Identities = 79/354 (22%), Positives = 132/354 (37%), Gaps = 94/354 (26%)
Query: 30 IILVSSANEIDVRPC---PLNPNEHKGTIT-----------------WYKDDSKTPVSTE 69
++ + ++ E+++ PC L E + T+ WYK+ S+
Sbjct: 19 VLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRAERGGHWYKEGSRLA---- 74
Query: 70 QASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSSYCLRI-------KISAKFVENEPNL-- 120
A R+ + +L ED+G Y C+ R S L+ +++ + +P
Sbjct: 75 PAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDEDPKSHR 134
Query: 121 ------CYNAQAIF-------KQKLPVAGDGGLV---CPYMEFFKNENNELPKLQWYKDC 164
Y QA + ++KL G V CP N P ++W KD
Sbjct: 135 DPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAA------GNPTPTIRWLKDG 188
Query: 165 KPLLLDNIHFSGVKDR-----LIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLE 219
+ +N G++ R L++ +V RG YTC +Y + +
Sbjct: 189 QAFHGEN-RIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNY-----LLDVL 242
Query: 220 ENKPTRPVIVS--PANETMEVDLGSQIQLICNVTGQLSDIAYW----KWNGSVIDEDDPV 273
E P RP++ + PAN T V GS ++L+C V W NGS D
Sbjct: 243 ERSPHRPILQAGLPANTTAVV--GSDVELLCKVYSDAQPHIQWLKHIVINGSSFGAD--- 297
Query: 274 LGEDYYSVENPANKRRSTLITVLNISEIESRFYKH-------PFTCFAKNTHGI 320
G Y V A+ +N SE+E + ++ +TC A N+ G+
Sbjct: 298 -GFPYVQVLKTAD---------INSSEVEVLYLRNVSAEDAGEYTCLAGNSIGL 341
>gi|47524173 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 52.0 bits (123), Expect = 1e-06
Identities = 79/354 (22%), Positives = 132/354 (37%), Gaps = 94/354 (26%)
Query: 30 IILVSSANEIDVRPC---PLNPNEHKGTIT-----------------WYKDDSKTPVSTE 69
++ + ++ E+++ PC L E + T+ WYK+ S+
Sbjct: 19 VLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRAERGGHWYKEGSRLA---- 74
Query: 70 QASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSSYCLRI-------KISAKFVENEPNL-- 120
A R+ + +L ED+G Y C+ R S L+ +++ + +P
Sbjct: 75 PAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDEDPKSHR 134
Query: 121 ------CYNAQAIF-------KQKLPVAGDGGLV---CPYMEFFKNENNELPKLQWYKDC 164
Y QA + ++KL G V CP N P ++W KD
Sbjct: 135 DPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAA------GNPTPTIRWLKDG 188
Query: 165 KPLLLDNIHFSGVKDR-----LIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLE 219
+ +N G++ R L++ +V RG YTC +Y + +
Sbjct: 189 QAFHGEN-RIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNY-----LLDVL 242
Query: 220 ENKPTRPVIVS--PANETMEVDLGSQIQLICNVTGQLSDIAYW----KWNGSVIDEDDPV 273
E P RP++ + PAN T V GS ++L+C V W NGS D
Sbjct: 243 ERSPHRPILQAGLPANTTAVV--GSDVELLCKVYSDAQPHIQWLKHIVINGSSFGAD--- 297
Query: 274 LGEDYYSVENPANKRRSTLITVLNISEIESRFYKH-------PFTCFAKNTHGI 320
G Y V A+ +N SE+E + ++ +TC A N+ G+
Sbjct: 298 -GFPYVQVLKTAD---------INSSEVEVLYLRNVSAEDAGEYTCLAGNSIGL 341
>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
[Homo sapiens]
Length = 1093
Score = 52.0 bits (123), Expect = 1e-06
Identities = 38/149 (25%), Positives = 63/149 (42%), Gaps = 12/149 (8%)
Query: 55 ITWYKDDSKT-PVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSSYCLRIKISAKF 113
I W KD P + E+ + + + K++D+G Y C +NS+ + +
Sbjct: 630 IAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAGVYSCTAQNSAGSISANATLTV 689
Query: 114 VENEPNLCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKDCKPL-LLDNI 172
+E P+L + + + V L C K N P++ W+K +PL L +
Sbjct: 690 LET-PSLVVPLE---DRVVSVGETVALQC------KATGNPPPRITWFKGDRPLSLTERH 739
Query: 173 HFSGVKDRLIVMNVAEKHRGNYTCHASYT 201
H + L+V NV + G YTC S T
Sbjct: 740 HLTPDNQLLVVQNVVAEDAGRYTCEMSNT 768
>gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens]
Length = 2623
Score = 49.7 bits (117), Expect = 7e-06
Identities = 68/311 (21%), Positives = 121/311 (38%), Gaps = 48/311 (15%)
Query: 25 EREEKIILVSSANEIDV------RPCPLNPNEHKGTITWYKDDSKTPVSTEQASR--IHQ 76
ER K I V S + +++ RP P T+TW + + Q SR +
Sbjct: 1749 ERRTKEITVHSGSTVELKCRAEGRPSP--------TVTWILANQTVVSESSQGSRQAVVT 1800
Query: 77 HKEKLWFVPAKVEDSGHYYCVVRNSSYCLRIKISAKFVENEPNLCYNAQAIF------KQ 130
L + D G Y CV N + + + + P + + +
Sbjct: 1801 VDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESL 1860
Query: 131 KLPVAGDGGLVCPYMEFFKNENNELPKLQWYKDCKPLLLDNIHFSGVKDRLIVMNVAEKH 190
KLP G P + + ++ E+ LQ + + K L N L + N+A
Sbjct: 1861 KLPCTAKG-TPQPSVYWVLSDGTEVKPLQ-FTNSKLFLFSN-------GTLYIRNLASSD 1911
Query: 191 RGNYTCHASYTYLGKQYPITRVIEFITLEENKPTRPVIVSPANETMEVDLGSQIQLICNV 250
RG Y C A+ + G + R + +T+EE + T P I + + + EV+ G ++ L C+
Sbjct: 1912 RGTYECIATSS-TGSE----RRVVMLTMEE-RVTSPRIEAASQKRTEVNFGDKLLLNCSA 1965
Query: 251 TGQLSDIAYWKWNGSVIDEDDPVLGEDYYSVENPANKRRSTLITVLNISEIESRFYKHPF 310
TG+ W+ + + +G + N + + + +++E +S Y
Sbjct: 1966 TGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGS-------LFIGSVTEKDSGVY---- 2014
Query: 311 TCFAKNTHGID 321
C A+N G D
Sbjct: 2015 LCVARNKMGDD 2025
>gi|237858679 neurofascin isoform 3 precursor [Homo sapiens]
Length = 1174
Score = 48.5 bits (114), Expect = 2e-05
Identities = 54/237 (22%), Positives = 90/237 (37%), Gaps = 39/237 (16%)
Query: 55 ITWYKDDSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRNS------SYCLRIK 108
I WYK P ++ + L EDSG Y+C+ N + +R+K
Sbjct: 289 IAWYKKGGDLP---SDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVK 345
Query: 109 ISAKFVENEPNLCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKDCKPL- 167
+ +++ NL L DG LVC + N P +QW + +PL
Sbjct: 346 AAPYWLDEPKNLI----------LAPGEDGRLVC------RANGNPKPTVQWMVNGEPLQ 389
Query: 168 -LLDNIHFSGVKDRLIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLEENKPTRP 226
N + D +I + R Y C+ S ++ F+++ + P
Sbjct: 390 SAPPNPNREVAGDTIIFRDTQISSRAVYQCNTS-----NEHGYLLANAFVSVLD---VPP 441
Query: 227 VIVSPANETMEVDLGSQIQLICNVTGQLSDIAYWKWNGSVIDEDDPVLGEDYYSVEN 283
++SP N+ + V L ++ +L C G W NG + D G +Y+ EN
Sbjct: 442 RMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLD----GGNYHVYEN 494
Score = 40.0 bits (92), Expect = 0.006
Identities = 38/164 (23%), Positives = 62/164 (37%), Gaps = 24/164 (14%)
Query: 156 PKLQWYKDCKPLLLDNIHFSGVKDRLIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEF 215
P + WYK L D F L + NV+E+ G Y C AS ++ I+ ++
Sbjct: 287 PDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKA 346
Query: 216 ITLEENKPTRPVIVSPANETMEVDLGSQIQLICNVTGQLSDIAYWKWNGSVIDEDDPVLG 275
++P + +I++P G +L+C G W NG + P
Sbjct: 347 APYWLDEP-KNLILAP---------GEDGRLVCRANGNPKPTVQWMVNGEPLQSAPP--- 393
Query: 276 EDYYSVENPANKRRSTLITVLNISEIESRFYKHPFTCFAKNTHG 319
NP N+ + + ++I SR + C N HG
Sbjct: 394 -------NP-NREVAGDTIIFRDTQISSRAV---YQCNTSNEHG 426
Score = 35.4 bits (80), Expect = 0.14
Identities = 38/148 (25%), Positives = 58/148 (39%), Gaps = 15/148 (10%)
Query: 54 TITWYKDDSKTPVSTEQASRIHQHKE-KLWFVPAKVEDSGHYYCVVRNSSYCLRIKISAK 112
T+ W+K+ S H ++ L + ED G Y CV N I K
Sbjct: 472 TLRWFKNGQG---SNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATN--------ILGK 520
Query: 113 FVENEPNL-CYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKDCKPLLLDN 171
EN+ L + I++ G K++ + + W KD +PL + N
Sbjct: 521 -AENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGN 579
Query: 172 IHFSGVKDRLIVMNVAEKHRGNYTCHAS 199
D L + VAE+ +G+YTC AS
Sbjct: 580 -RMKKEDDSLTIFGVAERDQGSYTCVAS 606
>gi|237858677 neurofascin isoform 2 precursor [Homo sapiens]
Length = 1189
Score = 48.5 bits (114), Expect = 2e-05
Identities = 54/237 (22%), Positives = 90/237 (37%), Gaps = 39/237 (16%)
Query: 55 ITWYKDDSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRNS------SYCLRIK 108
I WYK P ++ + L EDSG Y+C+ N + +R+K
Sbjct: 289 IAWYKKGGDLP---SDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVK 345
Query: 109 ISAKFVENEPNLCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKDCKPL- 167
+ +++ NL L DG LVC + N P +QW + +PL
Sbjct: 346 AAPYWLDEPKNLI----------LAPGEDGRLVC------RANGNPKPTVQWMVNGEPLQ 389
Query: 168 -LLDNIHFSGVKDRLIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLEENKPTRP 226
N + D +I + R Y C+ S ++ F+++ + P
Sbjct: 390 SAPPNPNREVAGDTIIFRDTQISSRAVYQCNTS-----NEHGYLLANAFVSVLD---VPP 441
Query: 227 VIVSPANETMEVDLGSQIQLICNVTGQLSDIAYWKWNGSVIDEDDPVLGEDYYSVEN 283
++SP N+ + V L ++ +L C G W NG + D G +Y+ EN
Sbjct: 442 RMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLD----GGNYHVYEN 494
Score = 40.0 bits (92), Expect = 0.006
Identities = 38/164 (23%), Positives = 62/164 (37%), Gaps = 24/164 (14%)
Query: 156 PKLQWYKDCKPLLLDNIHFSGVKDRLIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEF 215
P + WYK L D F L + NV+E+ G Y C AS ++ I+ ++
Sbjct: 287 PDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKA 346
Query: 216 ITLEENKPTRPVIVSPANETMEVDLGSQIQLICNVTGQLSDIAYWKWNGSVIDEDDPVLG 275
++P + +I++P G +L+C G W NG + P
Sbjct: 347 APYWLDEP-KNLILAP---------GEDGRLVCRANGNPKPTVQWMVNGEPLQSAPP--- 393
Query: 276 EDYYSVENPANKRRSTLITVLNISEIESRFYKHPFTCFAKNTHG 319
NP N+ + + ++I SR + C N HG
Sbjct: 394 -------NP-NREVAGDTIIFRDTQISSRAV---YQCNTSNEHG 426
Score = 35.8 bits (81), Expect = 0.11
Identities = 46/184 (25%), Positives = 68/184 (36%), Gaps = 24/184 (13%)
Query: 54 TITWYKDDSKTPVSTEQASRIHQHKE-KLWFVPAKVEDSGHYYCVVRNSSYCLRIKISAK 112
T+ W+K+ S H ++ L + ED G Y CV N I K
Sbjct: 472 TLRWFKNGQG---SNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATN--------ILGK 520
Query: 113 FVENEPNL-CYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKDCKPLLLDN 171
EN+ L + I++ G K++ + + W KD +PL + N
Sbjct: 521 -AENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGN 579
Query: 172 IHFSGVKDRLIVMNVAEKHRGNYTCHASYTY---LGKQY------PITRVIEFITLEENK 222
D L + VAE+ +G+YTC AS L K Y T L + +
Sbjct: 580 -RMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLADQATPTNRLAALPKGR 638
Query: 223 PTRP 226
P RP
Sbjct: 639 PDRP 642
>gi|89903008 neurofascin isoform 4 precursor [Homo sapiens]
Length = 1169
Score = 48.5 bits (114), Expect = 2e-05
Identities = 54/237 (22%), Positives = 90/237 (37%), Gaps = 39/237 (16%)
Query: 55 ITWYKDDSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRNS------SYCLRIK 108
I WYK P ++ + L EDSG Y+C+ N + +R+K
Sbjct: 289 IAWYKKGGDLP---SDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVK 345
Query: 109 ISAKFVENEPNLCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKDCKPL- 167
+ +++ NL L DG LVC + N P +QW + +PL
Sbjct: 346 AAPYWLDEPKNLI----------LAPGEDGRLVC------RANGNPKPTVQWMVNGEPLQ 389
Query: 168 -LLDNIHFSGVKDRLIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLEENKPTRP 226
N + D +I + R Y C+ S ++ F+++ + P
Sbjct: 390 SAPPNPNREVAGDTIIFRDTQISSRAVYQCNTS-----NEHGYLLANAFVSVLD---VPP 441
Query: 227 VIVSPANETMEVDLGSQIQLICNVTGQLSDIAYWKWNGSVIDEDDPVLGEDYYSVEN 283
++SP N+ + V L ++ +L C G W NG + D G +Y+ EN
Sbjct: 442 RMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLD----GGNYHVYEN 494
Score = 40.0 bits (92), Expect = 0.006
Identities = 38/164 (23%), Positives = 62/164 (37%), Gaps = 24/164 (14%)
Query: 156 PKLQWYKDCKPLLLDNIHFSGVKDRLIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEF 215
P + WYK L D F L + NV+E+ G Y C AS ++ I+ ++
Sbjct: 287 PDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKA 346
Query: 216 ITLEENKPTRPVIVSPANETMEVDLGSQIQLICNVTGQLSDIAYWKWNGSVIDEDDPVLG 275
++P + +I++P G +L+C G W NG + P
Sbjct: 347 APYWLDEP-KNLILAP---------GEDGRLVCRANGNPKPTVQWMVNGEPLQSAPP--- 393
Query: 276 EDYYSVENPANKRRSTLITVLNISEIESRFYKHPFTCFAKNTHG 319
NP N+ + + ++I SR + C N HG
Sbjct: 394 -------NP-NREVAGDTIIFRDTQISSRAV---YQCNTSNEHG 426
Score = 35.4 bits (80), Expect = 0.14
Identities = 38/148 (25%), Positives = 58/148 (39%), Gaps = 15/148 (10%)
Query: 54 TITWYKDDSKTPVSTEQASRIHQHKE-KLWFVPAKVEDSGHYYCVVRNSSYCLRIKISAK 112
T+ W+K+ S H ++ L + ED G Y CV N I K
Sbjct: 472 TLRWFKNGQG---SNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATN--------ILGK 520
Query: 113 FVENEPNL-CYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKDCKPLLLDN 171
EN+ L + I++ G K++ + + W KD +PL + N
Sbjct: 521 -AENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGN 579
Query: 172 IHFSGVKDRLIVMNVAEKHRGNYTCHAS 199
D L + VAE+ +G+YTC AS
Sbjct: 580 -RMKKEDDSLTIFGVAERDQGSYTCVAS 606
>gi|237858682 neurofascin isoform 6 precursor [Homo sapiens]
Length = 613
Score = 48.5 bits (114), Expect = 2e-05
Identities = 55/231 (23%), Positives = 89/231 (38%), Gaps = 27/231 (11%)
Query: 55 ITWYKDDSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSSYCLRIKISAKFV 114
I WYK P ++ + L EDSG Y+C+ N +R IS + V
Sbjct: 272 IAWYKKGGDLP---SDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVR-V 327
Query: 115 ENEPNLCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKDCKPLLL--DNI 172
+ P + + L DG LVC + N P +QW + +PL N
Sbjct: 328 KAAPYWLDEPKNLI---LAPGEDGRLVC------RANGNPKPTVQWMVNGEPLQSAPPNP 378
Query: 173 HFSGVKDRLIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLEENKPTRPVIVSPA 232
+ D +I + R Y C+ S ++ F+++ + P ++SP
Sbjct: 379 NREVAGDTIIFRDTQISSRAVYQCNTS-----NEHGYLLANAFVSVLDVPPR---MLSPR 430
Query: 233 NETMEVDLGSQIQLICNVTGQLSDIAYWKWNGSVIDEDDPVLGEDYYSVEN 283
N+ + V L ++ +L C G W NG + D G +Y+ EN
Sbjct: 431 NQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLD----GGNYHVYEN 477
Score = 40.8 bits (94), Expect = 0.003
Identities = 58/276 (21%), Positives = 98/276 (35%), Gaps = 43/276 (15%)
Query: 55 ITWYKDDSKTPVSTEQASRIHQ-HKEKLWFVPAKVED-SGHYYCVVR---------NSSY 103
+ ++ S P++ Q R+ Q H L+F ++D Y C R + +
Sbjct: 166 VIFWMSSSMEPIT--QDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPF 223
Query: 104 CLRIKISAKFVENEPNLCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKD 163
L++ + E P+ Y Q + D L C P + WYK
Sbjct: 224 TLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIA------SGVPTPDIAWYKK 277
Query: 164 CKPLLLDNIHFSGVKDRLIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLEENKP 223
L D F L + NV+E+ G Y C AS ++ I+ ++ ++P
Sbjct: 278 GGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEP 337
Query: 224 TRPVIVSPANETMEVDLGSQIQLICNVTGQLSDIAYWKWNGSVIDEDDPVLGEDYYSVEN 283
+ +I++P G +L+C G W NG + P N
Sbjct: 338 -KNLILAP---------GEDGRLVCRANGNPKPTVQWMVNGEPLQSAPP----------N 377
Query: 284 PANKRRSTLITVLNISEIESRFYKHPFTCFAKNTHG 319
P N+ + + ++I SR + C N HG
Sbjct: 378 P-NREVAGDTIIFRDTQISSRAV---YQCNTSNEHG 409
Score = 35.4 bits (80), Expect = 0.14
Identities = 38/148 (25%), Positives = 58/148 (39%), Gaps = 15/148 (10%)
Query: 54 TITWYKDDSKTPVSTEQASRIHQHKE-KLWFVPAKVEDSGHYYCVVRNSSYCLRIKISAK 112
T+ W+K+ S H ++ L + ED G Y CV N I K
Sbjct: 455 TLRWFKNGQG---SNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATN--------ILGK 503
Query: 113 FVENEPNL-CYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKDCKPLLLDN 171
EN+ L + I++ G K++ + + W KD +PL + N
Sbjct: 504 -AENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGN 562
Query: 172 IHFSGVKDRLIVMNVAEKHRGNYTCHAS 199
D L + VAE+ +G+YTC AS
Sbjct: 563 -RMKKEDDSLTIFGVAERDQGSYTCVAS 589
>gi|237858680 neurofascin isoform 5 precursor [Homo sapiens]
Length = 619
Score = 48.5 bits (114), Expect = 2e-05
Identities = 55/231 (23%), Positives = 89/231 (38%), Gaps = 27/231 (11%)
Query: 55 ITWYKDDSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSSYCLRIKISAKFV 114
I WYK P ++ + L EDSG Y+C+ N +R IS + V
Sbjct: 278 IAWYKKGGDLP---SDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVR-V 333
Query: 115 ENEPNLCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKDCKPLLL--DNI 172
+ P + + L DG LVC + N P +QW + +PL N
Sbjct: 334 KAAPYWLDEPKNLI---LAPGEDGRLVC------RANGNPKPTVQWMVNGEPLQSAPPNP 384
Query: 173 HFSGVKDRLIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLEENKPTRPVIVSPA 232
+ D +I + R Y C+ S ++ F+++ + P ++SP
Sbjct: 385 NREVAGDTIIFRDTQISSRAVYQCNTS-----NEHGYLLANAFVSVLDVPPR---MLSPR 436
Query: 233 NETMEVDLGSQIQLICNVTGQLSDIAYWKWNGSVIDEDDPVLGEDYYSVEN 283
N+ + V L ++ +L C G W NG + D G +Y+ EN
Sbjct: 437 NQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLD----GGNYHVYEN 483
Score = 40.8 bits (94), Expect = 0.003
Identities = 58/276 (21%), Positives = 98/276 (35%), Gaps = 43/276 (15%)
Query: 55 ITWYKDDSKTPVSTEQASRIHQ-HKEKLWFVPAKVED-SGHYYCVVR---------NSSY 103
+ ++ S P++ Q R+ Q H L+F ++D Y C R + +
Sbjct: 172 VIFWMSSSMEPIT--QDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPF 229
Query: 104 CLRIKISAKFVENEPNLCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKD 163
L++ + E P+ Y Q + D L C P + WYK
Sbjct: 230 TLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIA------SGVPTPDIAWYKK 283
Query: 164 CKPLLLDNIHFSGVKDRLIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLEENKP 223
L D F L + NV+E+ G Y C AS ++ I+ ++ ++P
Sbjct: 284 GGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEP 343
Query: 224 TRPVIVSPANETMEVDLGSQIQLICNVTGQLSDIAYWKWNGSVIDEDDPVLGEDYYSVEN 283
+ +I++P G +L+C G W NG + P N
Sbjct: 344 -KNLILAP---------GEDGRLVCRANGNPKPTVQWMVNGEPLQSAPP----------N 383
Query: 284 PANKRRSTLITVLNISEIESRFYKHPFTCFAKNTHG 319
P N+ + + ++I SR + C N HG
Sbjct: 384 P-NREVAGDTIIFRDTQISSRAV---YQCNTSNEHG 415
Score = 35.4 bits (80), Expect = 0.14
Identities = 38/148 (25%), Positives = 58/148 (39%), Gaps = 15/148 (10%)
Query: 54 TITWYKDDSKTPVSTEQASRIHQHKE-KLWFVPAKVEDSGHYYCVVRNSSYCLRIKISAK 112
T+ W+K+ S H ++ L + ED G Y CV N I K
Sbjct: 461 TLRWFKNGQG---SNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATN--------ILGK 509
Query: 113 FVENEPNL-CYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKDCKPLLLDN 171
EN+ L + I++ G K++ + + W KD +PL + N
Sbjct: 510 -AENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGN 568
Query: 172 IHFSGVKDRLIVMNVAEKHRGNYTCHAS 199
D L + VAE+ +G+YTC AS
Sbjct: 569 -RMKKEDDSLTIFGVAERDQGSYTCVAS 595
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.420
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,924,386
Number of Sequences: 37866
Number of extensions: 993715
Number of successful extensions: 3336
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 30
Number of HSP's successfully gapped in prelim test: 136
Number of HSP's that attempted gapping in prelim test: 2484
Number of HSP's gapped (non-prelim): 779
length of query: 569
length of database: 18,247,518
effective HSP length: 108
effective length of query: 461
effective length of database: 14,157,990
effective search space: 6526833390
effective search space used: 6526833390
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.