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Search of human proteins with 4504655
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4504655 interleukin 18 receptor 1 precursor [Homo sapiens]
(541 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4504655 interleukin 18 receptor 1 precursor [Homo sapiens] 1100 0.0
gi|7657232 interleukin 1 receptor accessory protein-like 1 precu... 204 2e-52
gi|11225607 interleukin 1 receptor accessory protein-like 2 [Hom... 203 3e-52
gi|4504661 interleukin 1 receptor accessory protein isoform 1 [H... 194 1e-49
gi|4504659 interleukin 1 receptor, type I precursor [Homo sapiens] 190 3e-48
gi|27894324 interleukin 1 receptor-like 1 isoform 1 precursor [H... 172 7e-43
gi|4504657 interleukin 18 receptor accessory protein precursor [... 170 3e-42
gi|28416902 interleukin 1 receptor-like 2 precursor [Homo sapiens] 164 1e-40
gi|205277451 single Ig IL-1R-related molecule [Homo sapiens] 79 1e-14
gi|205277449 single Ig IL-1R-related molecule [Homo sapiens] 79 1e-14
gi|205277445 single Ig IL-1R-related molecule [Homo sapiens] 79 1e-14
gi|27894328 interleukin 1 receptor-like 1 isoform 2 precursor [H... 71 2e-12
gi|19882209 interleukin 1 receptor accessory protein isoform 2 [... 70 6e-12
gi|41350337 toll-like receptor 1 [Homo sapiens] 68 2e-11
gi|19718734 toll-like receptor 2 [Homo sapiens] 63 8e-10
gi|20143971 toll-like receptor 6 [Homo sapiens] 61 2e-09
gi|62865621 toll-like receptor 10 precursor [Homo sapiens] 57 3e-08
gi|62865618 toll-like receptor 10 precursor [Homo sapiens] 57 3e-08
gi|19924149 toll-like receptor 4 precursor [Homo sapiens] 53 8e-07
gi|27894334 interleukin 1 receptor, type II precursor [Homo sapi... 52 1e-06
gi|4758598 interleukin 1 receptor, type II precursor [Homo sapiens] 52 1e-06
gi|7706093 toll-like receptor 7 [Homo sapiens] 49 9e-06
gi|197276654 myeloid differentiation primary response gene 88 [H... 47 4e-05
gi|54607118 leucine-rich repeats and immunoglobulin-like domains... 46 8e-05
gi|20302168 toll-like receptor 8 [Homo sapiens] 41 0.002
gi|4507531 toll-like receptor 3 [Homo sapiens] 41 0.002
gi|7662320 leucine-rich repeats and immunoglobulin-like domains ... 39 0.009
gi|171460997 CD226 molecule precursor [Homo sapiens] 39 0.016
gi|13186249 fibroblast growth factor receptor 1 isoform 9 precur... 37 0.060
gi|13186236 fibroblast growth factor receptor 1 isoform 4 precur... 37 0.060
>gi|4504655 interleukin 18 receptor 1 precursor [Homo sapiens]
Length = 541
Score = 1100 bits (2845), Expect = 0.0
Identities = 541/541 (100%), Positives = 541/541 (100%)
Query: 1 MNCRELPLTLWVLISVSTAESCTSRPHITVVEGEPFYLKHCSCSLAHEIETTTKSWYKSS 60
MNCRELPLTLWVLISVSTAESCTSRPHITVVEGEPFYLKHCSCSLAHEIETTTKSWYKSS
Sbjct: 1 MNCRELPLTLWVLISVSTAESCTSRPHITVVEGEPFYLKHCSCSLAHEIETTTKSWYKSS 60
Query: 61 GSQEHVELNPRSSSRIALHDCVLEFWPVELNDTGSYFFQMKNYTQKWKLNVIRRNKHSCF 120
GSQEHVELNPRSSSRIALHDCVLEFWPVELNDTGSYFFQMKNYTQKWKLNVIRRNKHSCF
Sbjct: 61 GSQEHVELNPRSSSRIALHDCVLEFWPVELNDTGSYFFQMKNYTQKWKLNVIRRNKHSCF 120
Query: 121 TERQVTSKIVEVKKFFQITCENSYYQTLVNSTSLYKNCKKLLLENNKNPTIKKNAEFEDQ 180
TERQVTSKIVEVKKFFQITCENSYYQTLVNSTSLYKNCKKLLLENNKNPTIKKNAEFEDQ
Sbjct: 121 TERQVTSKIVEVKKFFQITCENSYYQTLVNSTSLYKNCKKLLLENNKNPTIKKNAEFEDQ 180
Query: 181 GYYSCVHFLHHNGKLFNITKTFNITIVEDRSNIVPVLLGPKLNHVAVELGKNVRLNCSAL 240
GYYSCVHFLHHNGKLFNITKTFNITIVEDRSNIVPVLLGPKLNHVAVELGKNVRLNCSAL
Sbjct: 181 GYYSCVHFLHHNGKLFNITKTFNITIVEDRSNIVPVLLGPKLNHVAVELGKNVRLNCSAL 240
Query: 241 LNEEDVIYWMFGEENGSDPNIHEEKEMRIMTPEGKWHASKVLRIENIGESNLNVLYNCTV 300
LNEEDVIYWMFGEENGSDPNIHEEKEMRIMTPEGKWHASKVLRIENIGESNLNVLYNCTV
Sbjct: 241 LNEEDVIYWMFGEENGSDPNIHEEKEMRIMTPEGKWHASKVLRIENIGESNLNVLYNCTV 300
Query: 301 ASTGGTDTKSFILVRKADMADIPGHVFTRGMIIAVLILVAVVCLVTVCVIYRVDLVLFYR 360
ASTGGTDTKSFILVRKADMADIPGHVFTRGMIIAVLILVAVVCLVTVCVIYRVDLVLFYR
Sbjct: 301 ASTGGTDTKSFILVRKADMADIPGHVFTRGMIIAVLILVAVVCLVTVCVIYRVDLVLFYR 360
Query: 361 HLTRRDETLTDGKTYDAFVSYLKECRPENGEEHTFAVEILPRVLEKHFGYKLCIFERDVV 420
HLTRRDETLTDGKTYDAFVSYLKECRPENGEEHTFAVEILPRVLEKHFGYKLCIFERDVV
Sbjct: 361 HLTRRDETLTDGKTYDAFVSYLKECRPENGEEHTFAVEILPRVLEKHFGYKLCIFERDVV 420
Query: 421 PGGAVVDEIHSLIEKSRRLIIVLSKSYMSNEVRYELESGLHEALVERKIKIILIEFTPVT 480
PGGAVVDEIHSLIEKSRRLIIVLSKSYMSNEVRYELESGLHEALVERKIKIILIEFTPVT
Sbjct: 421 PGGAVVDEIHSLIEKSRRLIIVLSKSYMSNEVRYELESGLHEALVERKIKIILIEFTPVT 480
Query: 481 DFTFLPQSLKLLKSHRVLKWKADKSLSYNSRFWKNLLYLMPAKTVKPGRDEPEVLPVLSE 540
DFTFLPQSLKLLKSHRVLKWKADKSLSYNSRFWKNLLYLMPAKTVKPGRDEPEVLPVLSE
Sbjct: 481 DFTFLPQSLKLLKSHRVLKWKADKSLSYNSRFWKNLLYLMPAKTVKPGRDEPEVLPVLSE 540
Query: 541 S 541
S
Sbjct: 541 S 541
>gi|7657232 interleukin 1 receptor accessory protein-like 1
precursor [Homo sapiens]
Length = 696
Score = 204 bits (518), Expect = 2e-52
Identities = 171/566 (30%), Positives = 277/566 (48%), Gaps = 64/566 (11%)
Query: 9 TLWVLISVSTAESCTSRP----HITVVEGEPFYLKHCSCSLAHEIETTTKS--------- 55
+L V+ +A+ CT V+ GEP +K C+L + T S
Sbjct: 18 SLKVVTKRGSADGCTDWSIDIKKYQVLVGEPVRIK---CALFYGYIRTNYSLAQSAGLSL 74
Query: 56 -WYKSSGSQEHVELNPRSSSRIALHDCVLEFWPVELNDTGSYFFQMKNYTQKWK----LN 110
WYKSSG + E SR++ + + F P L D+G Y ++N T K L
Sbjct: 75 MWYKSSGPGDFEEPIAFDGSRMSKEEDSIWFRPTLLQDSGLYACVIRNSTYCMKVSISLT 134
Query: 111 VIRRNKHSCFTERQVTSKIVEVKKFFQITC---ENSYYQTLVNSTSLYKNCK----KLLL 163
V + C+ + + E+ K +I+C E+ T YK C+ + +
Sbjct: 135 VGENDTGLCYNSKMKYFEKAELSKSKEISCRDIEDFLLPTREPEILWYKECRTKTWRPSI 194
Query: 164 ENNKNPTIKKNAEFEDQGYYSCVHFLHHNGKLFNITKTFNITIVEDRSNIVPVLLGP--- 220
++ + + +D G Y+C L + G F + +T +T+ ++ P LL P
Sbjct: 195 VFKRDTLLIREVREDDIGNYTCE--LKYGG--FVVRRTTELTVTAPLTDKPPKLLYPMES 250
Query: 221 KLNHVAVELGKNVRLNCSALL----NEEDVIYWMFGEE--NGSDPNIHEEKEMRIMTPE- 273
KL +LG + L C A + +IYWM GE+ D N E ++RI+
Sbjct: 251 KLTIQETQLGDSANLTCRAFFGYSGDVSPLIYWMKGEKFIEDLDENRVWESDIRILKEHL 310
Query: 274 GKWHASKVLRIENIGESNLNVLYNCTVASTGGTDTKSFILVRKADMADIPGHVFTRGMII 333
G+ S L ++++ E +L Y+C V + G S +L ++ M + G +
Sbjct: 311 GEQEVSISLIVDSVEEGDLGN-YSCYVENGNGRRHASVLLHKRELMYTVE----LAGGLG 365
Query: 334 AVLILVAVVCLVTVCVIYRVDLVLFYRHLTRRDETLTDGKTYDAFVSYLK----ECRPEN 389
A+L+L+ VCLVT+ Y+++++LFYR+ +E D K YDA++SY K + E
Sbjct: 366 AILLLL--VCLVTIYKCYKIEIMLFYRNHFGAEELDGDNKDYDAYLSYTKVDPDQWNQET 423
Query: 390 GEEHTFAVEILPRVLEKHFGYKLCIFERDVVPGGAVVDEIHSLIEKSRRLIIVLSKSYMS 449
GEE FA+EILP +LEKH+GYKL I +RD++P G ++++ +++S+RLIIV++ +Y+
Sbjct: 424 GEEERFALEILPDMLEKHYGYKLFIPDRDLIPTGTYIEDVARCVDQSKRLIIVMTPNYVV 483
Query: 450 NE--VRYELESGLHEALVERKIKIILIEFTPV------TDFTFLPQSLKLLKSHRVLKWK 501
+ELE+ L LV +IK+ILIE + + + L ++KLL V+KW
Sbjct: 484 RRGWSIFELETRLRNMLVTGEIKVILIECSELRGIMNYQEVEALKHTIKLL---TVIKWH 540
Query: 502 ADKSLSYNSRFWKNLLYLMPAKTVKP 527
K NS+FWK L Y MP K ++P
Sbjct: 541 GPKCNKLNSKFWKRLQYEMPFKRIEP 566
>gi|11225607 interleukin 1 receptor accessory protein-like 2 [Homo
sapiens]
Length = 686
Score = 203 bits (517), Expect = 3e-52
Identities = 171/536 (31%), Positives = 262/536 (48%), Gaps = 67/536 (12%)
Query: 33 GEPFYLKHCSCSLAHEIETTTKS----------WYKSSGSQEHVELNPRSSSRIALHDCV 82
GEP +K C+L + T S WYK+ G E + S R++ +
Sbjct: 46 GEPVRVK---CALFYSYIRTNYSTAQSTGLRLMWYKNKGDLEEPIIF--SEVRMSKEEDS 100
Query: 83 LEFWPVELNDTGSYFFQMKNYTQKWK----LNVIRRNKHSCFTERQVTSKIVEVKKFFQI 138
+ F E D+G Y ++N T K L V C+ R + EV K +I
Sbjct: 101 IWFHSAEAQDSGFYTCVLRNSTYCMKVSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEI 160
Query: 139 TC---ENSYYQTLVNSTSLYKNCK----KLLLENNKNPTIKKNAEFEDQGYYSCVHFLHH 191
+C ++ YK CK + ++ N + + + ED G Y+C L +
Sbjct: 161 SCPDMDDFKKSDQEPDVVWYKECKPKMWRSIIIQKGNALLIQEVQEEDGGNYTCE--LKY 218
Query: 192 NGKLFNITKTFNIT-IVEDRSNIVPVLLGPKLNH---VAVELGKNVRLNCSALLN----E 243
GKL T +T ++ D+ P L P N + V+LGK + + C A
Sbjct: 219 EGKLVRRTTELKVTALLTDKP---PKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGES 275
Query: 244 EDVIYWMFGEENGSDPNIH-EEKEMRIMTPE-GKWHASKVLRIENIGESNLNVLYNCTVA 301
+IYWM GE+ + H E E+R++ G+ L +++ E++L Y C V
Sbjct: 276 GPMIYWMKGEKFIEELAGHIREGEIRLLKEHLGEKEVELALIFDSVVEADL-ANYTCHVE 334
Query: 302 STGGTDTKSFILVRKADMADIPGHVFTRGMIIAVLILVAVVCLVTVCVIYRVDLVLFYRH 361
+ G S +L +K D+ + G + A+ +L+ ++ ++ C Y ++L+LFYR
Sbjct: 335 NRNGRKHASVLLRKK----DLIYKIELAGGLGAIFLLLVLLVVIYKC--YNIELMLFYRQ 388
Query: 362 LTRRDETLTDGKTYDAFVSYLK------ECRPENGEEHTFAVEILPRVLEKHFGYKLCIF 415
DET D K YDA++SY K +C +N EE FA+E+LP VLEKH+GYKL I
Sbjct: 389 HFGADETNDDNKEYDAYLSYTKVDQDTLDC--DNPEEEQFALEVLPDVLEKHYGYKLFIP 446
Query: 416 ERDVVPGGAVVDEIHSLIEKSRRLIIVLSKSYMSNE--VRYELESGLHEALVERKIKIIL 473
ERD++P G ++++ +E+SRRLIIVL+ Y+ +ELES LH LV +IK+IL
Sbjct: 447 ERDLIPSGTYMEDLTRYVEQSRRLIIVLTPDYILRRGWSIFELESRLHNMLVSGEIKVIL 506
Query: 474 IEFTPV------TDFTFLPQSLKLLKSHRVLKWKADKSLSYNSRFWKNLLYLMPAK 523
IE T + + L +S+KLL ++KWK KS NS+FWK+L+Y MP K
Sbjct: 507 IECTELKGKVNCQEVESLKRSIKLLS---LIKWKGSKSSKLNSKFWKHLVYEMPIK 559
>gi|4504661 interleukin 1 receptor accessory protein isoform 1 [Homo
sapiens]
Length = 570
Score = 194 bits (494), Expect = 1e-49
Identities = 166/530 (31%), Positives = 250/530 (47%), Gaps = 49/530 (9%)
Query: 28 ITVVEGEPFYLK--------HCSCSLAHEIETTTKSWYKSSGSQEHVE-LNPR-SSSRIA 77
I V E EP +K + S AH T WY + ++ E +N R +RI+
Sbjct: 35 IQVFEDEPARIKCPLFEHFLKFNYSTAHSAGLTL-IWYWTRQDRDLEEPINFRLPENRIS 93
Query: 78 LHDCVLEFWPVELNDTGSYFFQMKNYTQKWK----LNVIRRNKHSCFTE--RQVTSKIVE 131
VL F P LNDTG+Y ++N T K L V++ K SCF + K+
Sbjct: 94 KEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEVVQ--KDSCFNSPMKLPVHKLYI 151
Query: 132 VKKFFQITCEN--SYYQTLVNST-SLYKNCKKLLLENNKNPTIKKNAEF-----EDQGYY 183
+ITC N Y+ + V T + Y C K+ NN P N F + G Y
Sbjct: 152 EYGIQRITCPNVDGYFPSSVKPTITWYMGCYKIQNFNNVIPE-GMNLSFLIALISNNGNY 210
Query: 184 SCVHFLHHNGKLFNITKTFNITIVEDRSNIVPVLLGPKLNHVAVEL--GKNVRLNC---- 237
+CV NG+ F++T+T + +V N VP ++ +HV E G+ + + C
Sbjct: 211 TCVVTYPENGRTFHLTRTLTVKVVGSPKNAVPPVIHSPNDHVVYEKEPGEELLIPCTVYF 270
Query: 238 SALLNEEDVIYWMFGEENGSDPNIHEEKEMRIMTPEGKWHA-SKVLRIENIGESNLNVLY 296
S L++ + ++W + D I I + +++L I+ + +L Y
Sbjct: 271 SFLMDSRNEVWWTIDGKKPDDITIDVTINESISHSRTEDETRTQILSIKKVTSEDLKRSY 330
Query: 297 NCTVASTGGTDTKSFILVRKADMADIPGHVFTRGMIIAV-LILVAVVCLVTVCVIYRVDL 355
C S G K+ + +K +P +T + ++ VV L+ V +Y +++
Sbjct: 331 VCHARSAKGEVAKAAKVKQK-----VPAPRYTVELACGFGATVLLVVILIVVYHVYWLEM 385
Query: 356 VLFYRHLTRRDETLTDGKTYDAFVSYLKECRPENGEEHTFAVEILPRVLEKHFGYKLCIF 415
VLFYR DET+ DGK YD +VSY + N EE F + L VLE FGYKLCIF
Sbjct: 386 VLFYRAHFGTDETILDGKEYDIYVSYAR-----NAEEEEFVLLTLRGVLENEFGYKLCIF 440
Query: 416 ERDVVPGGAVVDEIHSLIEKSRRLIIVLSKSYM--SNEVRYELESGLHEALVERKIKIIL 473
+RD +PGG V DE S I+KSRRL++VLS +Y+ + EL++GL I +IL
Sbjct: 441 DRDSLPGGIVTDETLSFIQKSRRLLVVLSPNYVLQGTQALLELKAGLENMASRGNINVIL 500
Query: 474 IEFTPVTDFTFLPQSLKLLKSHRVLKWKADKSLSYNSRFWKNLLYLMPAK 523
+++ V + T + + + V+KWK +KS RFWK L MP K
Sbjct: 501 VQYKAVKE-TKVKELKRAKTVLTVIKWKGEKSKYPQGRFWKQLQVAMPVK 549
>gi|4504659 interleukin 1 receptor, type I precursor [Homo sapiens]
Length = 569
Score = 190 bits (482), Expect = 3e-48
Identities = 151/560 (26%), Positives = 254/560 (45%), Gaps = 45/560 (8%)
Query: 12 VLISVSTAESCTSRPHITVVEGEPFYLKHCSCSLAHEIETTTKSWYKSSGSQEHVELNPR 71
+LIS A+ C R ++ + C L T +WYK ++
Sbjct: 13 LLISSLEADKCKEREEKIILVSSANEIDVRPCPLNPNEHKGTITWYKDDSK---TPVSTE 69
Query: 72 SSSRIALHDCVLEFWPVELNDTGSYFFQMKNYTQKWKLNV----IRRNKHSCFTERQVTS 127
+SRI H L F P ++ D+G Y+ ++N + ++ + + + C+ + +
Sbjct: 70 QASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSSYCLRIKISAKFVENEPNLCYNAQAIFK 129
Query: 128 KIVEVKKFFQITCENSYYQTLVNSTS------LYKNCKKLLLENN-----KNPTIKKNAE 176
+ + V + C Y + N + YK+CK LLL+N K+ I N
Sbjct: 130 QKLPVAGDGGLVCP--YMEFFKNENNELPKLQWYKDCKPLLLDNIHFSGVKDRLIVMNVA 187
Query: 177 FEDQGYYSCVHFLHHNGKLFNITKTFNITIVEDRSNIVPVLLGPKLNHVAVELGKNVRLN 236
+ +G Y+C + GK + IT+ +E+ PV++ P + V+LG ++L
Sbjct: 188 EKHRGNYTCHASYTYLGKQYPITRVIEFITLEENKPTRPVIVSPANETMEVDLGSQIQLI 247
Query: 237 CSALLNEEDVIYWMF-GEENGSDPNIHEEKEMRIMTPEGKWHAS--KVLRIENIGESNLN 293
C+ D+ YW + G D + E + P K ++ VL I I
Sbjct: 248 CNVTGQLSDIAYWKWNGSVIDEDDPVLGEDYYSVENPANKRRSTLITVLNISEIESRFYK 307
Query: 294 VLYNCTVASTGGTDTKSFILVRKADMADIPGHVFTRGMI-IAVLILVAVVCLVTVCVIYR 352
+ C +T G D L+ P F + MI I V + V +VC V + I++
Sbjct: 308 HPFTCFAKNTHGIDAAYIQLI-------YPVTNFQKHMIGICVTLTVIIVCSVFIYKIFK 360
Query: 353 VDLVLFYRHLTRRDETL--TDGKTYDAFVSYLKECRPENGEE-HTFAVEILPRVLEKHFG 409
+D+VL+YR + +DGKTYDA++ Y K + + F ++LP VLEK G
Sbjct: 361 IDIVLWYRDSCYDFLPIKASDGKTYDAYILYPKTVGEGSTSDCDIFVFKVLPEVLEKQCG 420
Query: 410 YKLCIFERDVVPGGAVVDEIHSLIEKSRRLIIVLSK-----SYMSNEVRYELESGLHEAL 464
YKL I+ RD G +V+ I+ ++KSRRLII+L + S++ E + ++ AL
Sbjct: 421 YKLFIYGRDDYVGEDIVEVINENVKKSRRLIIILVRETSGFSWLGGS--SEEQIAMYNAL 478
Query: 465 VERKIKIILIEFTPVTDFTFLPQSLKLLK-SHRVLKWKADKS---LSYNSRFWKNLLYLM 520
V+ IK++L+E + D+ +P+S+K +K H ++W D + S +RFWKN+ Y M
Sbjct: 479 VQDGIKVVLLELEKIQDYEKMPESIKFIKQKHGAIRWSGDFTQGPQSAKTRFWKNVRYHM 538
Query: 521 PAKTVKPGRDEPEVLPVLSE 540
P + P + P E
Sbjct: 539 PVQRRSPSSKHQLLSPATKE 558
>gi|27894324 interleukin 1 receptor-like 1 isoform 1 precursor [Homo
sapiens]
Length = 556
Score = 172 bits (436), Expect = 7e-43
Identities = 140/505 (27%), Positives = 231/505 (45%), Gaps = 37/505 (7%)
Query: 53 TKSWYKSSGSQEHVELNPRSSSRIALHDCVLEFWPVELNDTGSYFFQMK----NYTQKWK 108
T WY S Q + + + +R+ +L+F P + D+G Y ++ N T
Sbjct: 45 TVDWYYS---QTNKSIPTQERNRVFASGQLLKFLPAAVADSGIYTCIVRSPTFNRTGYAN 101
Query: 109 LNVIRRNKHSCFTERQVTSKIVEVKKFFQITCENSYYQTLVNSTSLYKNCKKLL---LEN 165
+ + ++ + + S + +K +I C +KNC+ L
Sbjct: 102 VTIYKKQSDCNVPDYLMYSTVSGSEKNSKIYCPTIDLYNWTAPLEWFKNCQALQGSRYRA 161
Query: 166 NKNPTIKKNAEFEDQGYYSCVHFLHHNGKLFNITKTFNITIVEDRS-NIVPVLLGPKLNH 224
+K+ + N ED G Y+C + NG +++T T + T+ +++ ++ PV+ P N
Sbjct: 162 HKSFLVIDNVMTEDAGDYTCKFIHNENGANYSVTATRSFTVKDEQGFSLFPVIGAPAQNE 221
Query: 225 VA-VELGKNVRLNCSALLNEED----VIYWMFGEENGSD---PNIHEEKEMRIMTPEGKW 276
+ VE+GKN L CSA + + W +D P I +E+ G
Sbjct: 222 IKEVEIGKNANLTCSACFGKGTQFLAAVLWQLNGTKITDFGEPRIQQEEGQNQSFSNGLA 281
Query: 277 HASKVLRIENIGESNLNVLYNCTVASTGGTDTKSFILVRKADMADIPGHVFTRGMIIAVL 336
VLRI ++ E +L + Y+C + G + L RK I H + + +
Sbjct: 282 CLDMVLRIADVKEEDLLLQYDCLALNLHGLRRHTVRLSRKNP---IDHHSIYCIIAVCSV 338
Query: 337 ILVAVVCLVTVCVIYRVDLVLFYRHLTRRDETLTDGKTYDAFVSYLKECRPENGE----E 392
L+ + LV + ++ ++ L +R + + +T DGK YDA+V Y + + E
Sbjct: 339 FLMLINVLVIILKMFWIEATLLWRDIAKPYKTRNDGKLYDAYVVYPRNYKSSTDGASRVE 398
Query: 393 HTFAVEILPRVLEKHFGYKLCIFERDVVPGGAVVDEIHSLIEKSRRLIIVLSKSYMSN-E 451
H F +ILP VLE GY LCI+ RD++PG VV + + I KSRR I +L+ N E
Sbjct: 399 H-FVHQILPDVLENKCGYTLCIYGRDMLPGEDVVTAVETNIRKSRRHIFILTPQITHNKE 457
Query: 452 VRYELESGLHEALVERKIKIILIEFTPVTDFTF-----LPQSLK-LLKSHRVLKWKAD-- 503
YE E LH AL++ K+ILIE +++ L SL+ L+K +KW+ D
Sbjct: 458 FAYEQEVALHCALIQNDAKVILIEMEALSELDMLQAEALQDSLQHLMKVQGTIKWREDHI 517
Query: 504 -KSLSYNSRFWKNLLYLMPAKTVKP 527
S NS+FWK++ Y MP + P
Sbjct: 518 ANKRSLNSKFWKHVRYQMPVPSKIP 542
>gi|4504657 interleukin 18 receptor accessory protein precursor
[Homo sapiens]
Length = 599
Score = 170 bits (431), Expect = 3e-42
Identities = 142/505 (28%), Positives = 235/505 (46%), Gaps = 63/505 (12%)
Query: 56 WYKSSGSQEHVELNPRSSSRIALHDCVLEFWPVELNDTGSYFFQMKNYTQ--------KW 107
WY+ + + +E +S I C L F +N++GSY + K K
Sbjct: 84 WYQQPSNGDPLEDIRKSYPHIIQDKCTLHFLTPGVNNSGSYICRPKMIKSPYDVACCVKM 143
Query: 108 KLNVIRRNKHSCFTERQVTSKIVEVKKFFQITCENSYYQTLVNSTSL--YKNCKKLLLEN 165
L V + SC ++ + I+C + Q+ S ++ YKN K L +E
Sbjct: 144 ILEVKPQTNASCEYSASHKQDLL-LGSTGSISCPSLSCQSDAQSPAVTWYKNGKLLSVER 202
Query: 166 NKNPTIKKNAEFEDQGYYSCVHFLHHNGKLFNITKTFNITIVEDRSNIVPVLLGPKLNHV 225
+ + + ++ QG Y C + + + + + + + P +L P + +
Sbjct: 203 SNRIVVDEVYDYH-QGTYVCDYTQSDTVSSWTVRAVVQVRTIVGDTKLKPDILDPVEDTL 261
Query: 226 AVELGKNVRLNCSALLNEE----DVIYWMFGEENGSDPNIHEEKEMRIMTPEGKWHASKV 281
VELGK + ++C A E VI W + + E + PE K S +
Sbjct: 262 EVELGKPLTISCKARFGFERVFNPVIKWYIKDS---------DLEWEVSVPEAKSIKSTL 312
Query: 282 --------LRIENIGESNLNVLYNCTVASTGGTDTKSFILVRKADMADIPGHVFTRGMII 333
+ +E + + +L + C V ++ G T+S L K RG+++
Sbjct: 313 KDEIIERNIILEKVTQRDLRRKFVCFVQNSIGNTTQSVQLKEK------------RGVVL 360
Query: 334 AVLILVAVVCLVTV----CVIYR--VDLVLFYRHLTRRDETLTDGKTYDAFVSYLK---- 383
++L + LV V ++YR +++VL YR +D+TL D K +DAFVSY K
Sbjct: 361 LYILLGTIGTLVAVLAASALLYRHWIEIVLLYRTYQSKDQTLGDKKDFDAFVSYAKWSSF 420
Query: 384 --ECRPENGEEHTFAVEILPRVLEKHFGYKLCIFERDVVPGGAVVDEIHSLIEKSRRLII 441
E EEH A+ + P VLE +GY LC+ ERDV PGG ++I S+I++SRR I
Sbjct: 421 PSEATSSLSEEH-LALSLFPDVLENKYGYSLCLLERDVAPGGVYAEDIVSIIKRSRRGIF 479
Query: 442 VLSKSYMSNEVRYELESGLHEALVERKIKIILIEFTPVTDFTFLPQSLKLLKSHRVL--- 498
+LS +Y++ +EL++ ++ AL ++ +K+ILI+F + LP +K K+ RVL
Sbjct: 480 ILSPNYVNGPSIFELQAAVNLALDDQTLKLILIKFCYFQEPESLPHLVK--KALRVLPTV 537
Query: 499 KWKADKSLSYNSRFWKNLLYLMPAK 523
W+ KS+ NSRFW + Y MP K
Sbjct: 538 TWRGLKSVPPNSRFWAKMRYHMPVK 562
>gi|28416902 interleukin 1 receptor-like 2 precursor [Homo sapiens]
Length = 575
Score = 164 bits (416), Expect = 1e-40
Identities = 140/505 (27%), Positives = 236/505 (46%), Gaps = 48/505 (9%)
Query: 55 SWYKSSGSQEHVELNPRSSSRIALHDCVLEFWPVELNDTGSYFFQMK--NYTQKWKLNVI 112
+WYK+S + ++ SRI + + F P+E D+G Y +K + + +N+
Sbjct: 55 TWYKNSSK---IPVSKIIQSRIHQDETWILFLPMEWGDSGVYQCVIKGRDSCHRIHVNLT 111
Query: 113 RRNKHSCFTE-------RQVTSKIVEVKKFFQITCENSYYQTLV-NSTSLYKNCKKLLLE 164
KH C T +I+ + K +TC + ++ V YK+C ++ E
Sbjct: 112 VFEKHWCDTSIGGLPNLSDEYKQILHLGKDDSLTCHLHFPKSCVLGPIKWYKDCNEIKGE 171
Query: 165 NN---KNPTIKKNAEFEDQGYYSCVHFLHHNGKLFNITKTFNITIVEDRS--NIVPVLLG 219
+ + N ED+G Y+C L H+GK + + ++I E VP ++
Sbjct: 172 RFTVLETRLLVSNVSAEDRGNYACQAILTHSGKQYEVLNGITVSITERAGYGGSVPKIIY 231
Query: 220 PKLNHVAVELGKNVRLNCSALLNEEDVIYWMFGEENGS-DPNIHEEKEMRIMTPEG-KWH 277
PK + + V+LG + ++C+ +++ + N D E K +R EG + H
Sbjct: 232 PKNHSIEVQLGTTLIVDCNVTDTKDNTNLRCWRVNNTLVDDYYDESKRIR----EGVETH 287
Query: 278 ASKVLRIENIGESNLNVL------YNCTVASTGGTDTKSFILVRKADMADIPGHVFTRGM 331
S R N+ N+ L Y G T IL +P F +
Sbjct: 288 VS--FREHNLYTVNITFLEVKMEDYGLPFMCHAGVSTAYIIL-------QLPAPDFRAYL 338
Query: 332 IIAVLILVAV-VCLVTVCVIYRVDLVLFYRHLTRRDETLTDGKTYDAFVSYLKECRPENG 390
I ++ LVAV V +V + I+++D+VL+YR ET+ DGK YDA+V Y K +
Sbjct: 339 IGGLIALVAVAVSVVYIYNIFKIDIVLWYRSAFHSTETIVDGKLYDAYVLYPKPHKESQR 398
Query: 391 EE-HTFAVEILPRVLEKHFGYKLCIFERDVVPGGAVVDEIHSLIEKSRRLIIVL---SKS 446
+ ILP VLE+ GYKL IF RD PG AV + I ++ RRLI+++ S
Sbjct: 399 HAVDALVLNILPEVLERQCGYKLFIFGRDEFPGQAVANVIDENVKLCRRLIVIVVPESLG 458
Query: 447 YMSNEVRYELESGLHEALVERKIKIILIEFTPVTDFTFLPQSLKLLK-SHRVLKWKAD-- 503
+ + E + ++ AL++ +K+ILIE + D+T +P+S++ +K H ++W D
Sbjct: 459 FGLLKNLSEEQIAVYSALIQDGMKVILIELEKIEDYTVMPESIQYIKQKHGAIRWHGDFT 518
Query: 504 -KSLSYNSRFWKNLLYLMPAKTVKP 527
+S ++FWK + Y MP + +P
Sbjct: 519 EQSQCMKTKFWKTVRYHMPPRRCRP 543
>gi|205277451 single Ig IL-1R-related molecule [Homo sapiens]
Length = 410
Score = 78.6 bits (192), Expect = 1e-14
Identities = 90/337 (26%), Positives = 155/337 (45%), Gaps = 42/337 (12%)
Query: 215 PVLLGPKLNHVA-VELGKNVRLNCSALLNEEDVIYWMFGEENGSDPNIHEEKEMRIMTPE 273
P L P + V LG +V LNC+A W+ + S P++ K+ +
Sbjct: 9 PDFLSPSEDQVLRPALGSSVALNCTA---------WVVSGPHCSLPSVQWLKDGLPLGIG 59
Query: 274 G----------KWHASKVLRIENIGESNLNV-LYNCTVASTGGTDTKSFILVRKADMADI 322
G K + S+VL +G + + +Y S SF L R + +
Sbjct: 60 GHYSLHEYSWVKANLSEVLVSSVLGVNVTSTEVYGAFTCSIQNISFSSFTLQRAGPTSHV 119
Query: 323 PGHVFTRGMIIAVLILVAVVCLVTVCVIYRVDLVLFYRHLTRRDETLTDGKTYDAFVSYL 382
++ ++L+L+A++ + V R++++L+Y+ E + DGK YDA+VSY
Sbjct: 120 AA------VLASLLVLLALLLAALLYVKCRLNVLLWYQDAYGEVE-INDGKLYDAYVSY- 171
Query: 383 KECRPENGEEHTFAVEILPRVLEKHFGYKLCIFERDVVPGGAVVDEIHSLIEKSRRLIIV 442
+C E+ F IL LE+ GYKL + +RD++P ++ + + RRLI+V
Sbjct: 172 SDCP----EDRKFVNFILKPQLERRRGYKLFLDDRDLLPRAEPSADLLVNLSRCRRLIVV 227
Query: 443 LSKSYMSNE-VRYELESGLHEALVERKIKIILIEFTPVTDFTFLPQSLKLLKSHR----V 497
LS +++S + GL L+E + I I F P +L+LL+ HR +
Sbjct: 228 LSDAFLSRAWCSHSFREGLCR-LLELTRRPIFITFEGQRRDPAHP-ALRLLRQHRHLVTL 285
Query: 498 LKWKADKSLSYNSRFWKNLLYLMPAKT-VKPGRDEPE 533
L W+ S++ +S FWK + +P K +P +P+
Sbjct: 286 LLWRPG-SVTPSSDFWKEVQLALPRKVQYRPVEGDPQ 321
>gi|205277449 single Ig IL-1R-related molecule [Homo sapiens]
Length = 410
Score = 78.6 bits (192), Expect = 1e-14
Identities = 90/337 (26%), Positives = 155/337 (45%), Gaps = 42/337 (12%)
Query: 215 PVLLGPKLNHVA-VELGKNVRLNCSALLNEEDVIYWMFGEENGSDPNIHEEKEMRIMTPE 273
P L P + V LG +V LNC+A W+ + S P++ K+ +
Sbjct: 9 PDFLSPSEDQVLRPALGSSVALNCTA---------WVVSGPHCSLPSVQWLKDGLPLGIG 59
Query: 274 G----------KWHASKVLRIENIGESNLNV-LYNCTVASTGGTDTKSFILVRKADMADI 322
G K + S+VL +G + + +Y S SF L R + +
Sbjct: 60 GHYSLHEYSWVKANLSEVLVSSVLGVNVTSTEVYGAFTCSIQNISFSSFTLQRAGPTSHV 119
Query: 323 PGHVFTRGMIIAVLILVAVVCLVTVCVIYRVDLVLFYRHLTRRDETLTDGKTYDAFVSYL 382
++ ++L+L+A++ + V R++++L+Y+ E + DGK YDA+VSY
Sbjct: 120 AA------VLASLLVLLALLLAALLYVKCRLNVLLWYQDAYGEVE-INDGKLYDAYVSY- 171
Query: 383 KECRPENGEEHTFAVEILPRVLEKHFGYKLCIFERDVVPGGAVVDEIHSLIEKSRRLIIV 442
+C E+ F IL LE+ GYKL + +RD++P ++ + + RRLI+V
Sbjct: 172 SDCP----EDRKFVNFILKPQLERRRGYKLFLDDRDLLPRAEPSADLLVNLSRCRRLIVV 227
Query: 443 LSKSYMSNE-VRYELESGLHEALVERKIKIILIEFTPVTDFTFLPQSLKLLKSHR----V 497
LS +++S + GL L+E + I I F P +L+LL+ HR +
Sbjct: 228 LSDAFLSRAWCSHSFREGLCR-LLELTRRPIFITFEGQRRDPAHP-ALRLLRQHRHLVTL 285
Query: 498 LKWKADKSLSYNSRFWKNLLYLMPAKT-VKPGRDEPE 533
L W+ S++ +S FWK + +P K +P +P+
Sbjct: 286 LLWRPG-SVTPSSDFWKEVQLALPRKVQYRPVEGDPQ 321
>gi|205277445 single Ig IL-1R-related molecule [Homo sapiens]
Length = 410
Score = 78.6 bits (192), Expect = 1e-14
Identities = 90/337 (26%), Positives = 155/337 (45%), Gaps = 42/337 (12%)
Query: 215 PVLLGPKLNHVA-VELGKNVRLNCSALLNEEDVIYWMFGEENGSDPNIHEEKEMRIMTPE 273
P L P + V LG +V LNC+A W+ + S P++ K+ +
Sbjct: 9 PDFLSPSEDQVLRPALGSSVALNCTA---------WVVSGPHCSLPSVQWLKDGLPLGIG 59
Query: 274 G----------KWHASKVLRIENIGESNLNV-LYNCTVASTGGTDTKSFILVRKADMADI 322
G K + S+VL +G + + +Y S SF L R + +
Sbjct: 60 GHYSLHEYSWVKANLSEVLVSSVLGVNVTSTEVYGAFTCSIQNISFSSFTLQRAGPTSHV 119
Query: 323 PGHVFTRGMIIAVLILVAVVCLVTVCVIYRVDLVLFYRHLTRRDETLTDGKTYDAFVSYL 382
++ ++L+L+A++ + V R++++L+Y+ E + DGK YDA+VSY
Sbjct: 120 AA------VLASLLVLLALLLAALLYVKCRLNVLLWYQDAYGEVE-INDGKLYDAYVSY- 171
Query: 383 KECRPENGEEHTFAVEILPRVLEKHFGYKLCIFERDVVPGGAVVDEIHSLIEKSRRLIIV 442
+C E+ F IL LE+ GYKL + +RD++P ++ + + RRLI+V
Sbjct: 172 SDCP----EDRKFVNFILKPQLERRRGYKLFLDDRDLLPRAEPSADLLVNLSRCRRLIVV 227
Query: 443 LSKSYMSNE-VRYELESGLHEALVERKIKIILIEFTPVTDFTFLPQSLKLLKSHR----V 497
LS +++S + GL L+E + I I F P +L+LL+ HR +
Sbjct: 228 LSDAFLSRAWCSHSFREGLCR-LLELTRRPIFITFEGQRRDPAHP-ALRLLRQHRHLVTL 285
Query: 498 LKWKADKSLSYNSRFWKNLLYLMPAKT-VKPGRDEPE 533
L W+ S++ +S FWK + +P K +P +P+
Sbjct: 286 LLWRPG-SVTPSSDFWKEVQLALPRKVQYRPVEGDPQ 321
>gi|27894328 interleukin 1 receptor-like 1 isoform 2 precursor [Homo
sapiens]
Length = 328
Score = 71.2 bits (173), Expect = 2e-12
Identities = 65/280 (23%), Positives = 117/280 (41%), Gaps = 19/280 (6%)
Query: 53 TKSWYKSSGSQEHVELNPRSSSRIALHDCVLEFWPVELNDTGSYFFQMK----NYTQKWK 108
T WY S Q + + + +R+ +L+F P + D+G Y ++ N T
Sbjct: 45 TVDWYYS---QTNKSIPTQERNRVFASGQLLKFLPAAVADSGIYTCIVRSPTFNRTGYAN 101
Query: 109 LNVIRRNKHSCFTERQVTSKIVEVKKFFQITCENSYYQTLVNSTSLYKNCKKLL---LEN 165
+ + ++ + + S + +K +I C +KNC+ L
Sbjct: 102 VTIYKKQSDCNVPDYLMYSTVSGSEKNSKIYCPTIDLYNWTAPLEWFKNCQALQGSRYRA 161
Query: 166 NKNPTIKKNAEFEDQGYYSCVHFLHHNGKLFNITKTFNITIVEDRS-NIVPVLLGPKLNH 224
+K+ + N ED G Y+C + NG +++T T + T+ +++ ++ PV+ P N
Sbjct: 162 HKSFLVIDNVMTEDAGDYTCKFIHNENGANYSVTATRSFTVKDEQGFSLFPVIGAPAQNE 221
Query: 225 V-AVELGKNVRLNCSALLNEED----VIYWMFGEENGSD---PNIHEEKEMRIMTPEGKW 276
+ VE+GKN L CSA + + W +D P I +E+ G
Sbjct: 222 IKEVEIGKNANLTCSACFGKGTQFLAAVLWQLNGTKITDFGEPRIQQEEGQNQSFSNGLA 281
Query: 277 HASKVLRIENIGESNLNVLYNCTVASTGGTDTKSFILVRK 316
VLRI ++ E +L + Y+C + G + L RK
Sbjct: 282 CLDMVLRIADVKEEDLLLQYDCLALNLHGLRRHTVRLSRK 321
>gi|19882209 interleukin 1 receptor accessory protein isoform 2
[Homo sapiens]
Length = 356
Score = 69.7 bits (169), Expect = 6e-12
Identities = 85/322 (26%), Positives = 136/322 (42%), Gaps = 35/322 (10%)
Query: 28 ITVVEGEPFYLK--------HCSCSLAHEIETTTKSWYKSSGSQEHVE-LNPR-SSSRIA 77
I V E EP +K + S AH T WY + ++ E +N R +RI+
Sbjct: 35 IQVFEDEPARIKCPLFEHFLKFNYSTAHSAGLTL-IWYWTRQDRDLEEPINFRLPENRIS 93
Query: 78 LHDCVLEFWPVELNDTGSYFFQMKNYTQKWK----LNVIRRNKHSCFTE--RQVTSKIVE 131
VL F P LNDTG+Y ++N T K L V++ K SCF + K+
Sbjct: 94 KEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEVVQ--KDSCFNSPMKLPVHKLYI 151
Query: 132 VKKFFQITCEN--SYYQTLVNST-SLYKNCKKLLLENNKNPTIKKNAEF-----EDQGYY 183
+ITC N Y+ + V T + Y C K+ NN P N F + G Y
Sbjct: 152 EYGIQRITCPNVDGYFPSSVKPTITWYMGCYKIQNFNNVIPE-GMNLSFLIALISNNGNY 210
Query: 184 SCVHFLHHNGKLFNITKTFNITIVEDRSNIVPVLLGPKLNHVAVEL--GKNVRLNC---- 237
+CV NG+ F++T+T + +V N VP ++ +HV E G+ + + C
Sbjct: 211 TCVVTYPENGRTFHLTRTLTVKVVGSPKNAVPPVIHSPNDHVVYEKEPGEELLIPCTVYF 270
Query: 238 SALLNEEDVIYWMFGEENGSDPNIHEEKEMRIMTPEGKWHA-SKVLRIENIGESNLNVLY 296
S L++ + ++W + D I I + +++L I+ + +L Y
Sbjct: 271 SFLMDSRNEVWWTIDGKKPDDITIDVTINESISHSRTEDETRTQILSIKKVTSEDLKRSY 330
Query: 297 NCTVASTGGTDTKSFILVRKAD 318
C S G K+ + +K +
Sbjct: 331 VCHARSAKGEVAKAAKVKQKGN 352
>gi|41350337 toll-like receptor 1 [Homo sapiens]
Length = 786
Score = 67.8 bits (164), Expect = 2e-11
Identities = 66/221 (29%), Positives = 107/221 (48%), Gaps = 31/221 (14%)
Query: 313 LVRKADMADIPGHVFTRGMIIAVLILVAVVCLVTVCVIYRVDLVLFYRHL-----TRRD- 366
L++ M+++ ++ + I +LV V + ++C +DL + R + TRR
Sbjct: 566 LLKDFHMSELSCNITLLIVTIVATMLVLAVTVTSLCSY--LDLPWYLRMVCQWTQTRRRA 623
Query: 367 -----ETLTDGKTYDAFVSYLKECRPENGEEHTFAV-EILPRVLEKHFGYKLCIFERDVV 420
E L + AF+SY +G + + E+LP LEK G ++C+ ER+ V
Sbjct: 624 RNIPLEELQRNLQFHAFISY-------SGHDSFWVKNELLPN-LEKE-GMQICLHERNFV 674
Query: 421 PGGAVVDEIHSLIEKSRRLIIVLSKSYMSNE-VRYELESGLHEALVERKIKIILIEFTPV 479
PG ++V+ I + IEKS + I VLS +++ +E YEL H E +ILI P+
Sbjct: 675 PGKSIVENIITCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFHEGSNSLILILLEPI 734
Query: 480 TDFTFLPQSLKLLKS----HRVLKWKADKSLSYNSRFWKNL 516
++ +P S LKS L+W +K S FW NL
Sbjct: 735 PQYS-IPSSYHKLKSLMARRTYLEWPKEK--SKRGLFWANL 772
>gi|19718734 toll-like receptor 2 [Homo sapiens]
Length = 784
Score = 62.8 bits (151), Expect = 8e-10
Identities = 47/149 (31%), Positives = 74/149 (49%), Gaps = 18/149 (12%)
Query: 375 YDAFVSYLKECRPENGEEHTFAVEILPRVLEKHFG--YKLCIFERDVVPGGAVVDEIHSL 432
YDAFVSY E + VE L ++F +KLC+ +RD +PG ++D I
Sbjct: 641 YDAFVSY--------SERDAYWVENLMVQELENFNPPFKLCLHKRDFIPGKWIIDNIIDS 692
Query: 433 IEKSRRLIIVLSKSYMSNE-VRYELESGLHEALVERKIKIILIEFTPVTDFTFLPQSL-- 489
IEKS + + VLS++++ +E +YEL+ E ILI P+ + +PQ
Sbjct: 693 IEKSHKTVFVLSENFVKSEWCKYELDFSHFRLFDENNDAAILILLEPI-EKKAIPQRFCK 751
Query: 490 --KLLKSHRVLKWKADKSLSYNSRFWKNL 516
K++ + L+W D+ + FW NL
Sbjct: 752 LRKIMNTKTYLEWPMDE--AQREGFWVNL 778
>gi|20143971 toll-like receptor 6 [Homo sapiens]
Length = 796
Score = 61.2 bits (147), Expect = 2e-09
Identities = 74/259 (28%), Positives = 117/259 (45%), Gaps = 48/259 (18%)
Query: 284 IENIGESNLNVL------YNCTVA-STGGTDTKSFILVRKADMADIPGHVFTRGMIIAVL 336
++NI + + VL Y C S G+ K F M+++ ++ + I
Sbjct: 541 VKNIDQVSSEVLEGWPDSYKCDYPESYRGSPLKDF------HMSELSCNITLLIVTIGAT 594
Query: 337 ILVAVVCLVTVCVIYRVDLVLFYRHL-----TRRD------ETLTDGKTYDAFVSYLKEC 385
+LV V + ++C+ +DL + R + TRR E L + AF+SY
Sbjct: 595 MLVLAVTVTSLCIY--LDLPWYLRMVCQWTQTRRRARNIPLEELQRNLQFHAFISY---- 648
Query: 386 RPENGEEHTFA---VEILPRVLEKHFGYKLCIFERDVVPGGAVVDEIHSLIEKSRRLIIV 442
EH A E++P LEK ++C+ ER+ VPG ++V+ I + IEKS + I V
Sbjct: 649 -----SEHDSAWVKSELVP-YLEKE-DIQICLHERNFVPGKSIVENIINCIEKSYKSIFV 701
Query: 443 LSKSYMSNE-VRYELESGLHEALVERKIKIILIEFTPVTDFTFLP---QSLKLLKSHRV- 497
LS +++ +E YEL H E +ILI P+ +P LK L + R
Sbjct: 702 LSPNFVQSEWCHYELYFAHHNLFHEGSNNLILILLEPIPQ-NSIPNKYHKLKALMTQRTY 760
Query: 498 LKWKADKSLSYNSRFWKNL 516
L+W +K S FW N+
Sbjct: 761 LQWPKEK--SKRGLFWANI 777
>gi|62865621 toll-like receptor 10 precursor [Homo sapiens]
Length = 811
Score = 57.4 bits (137), Expect = 3e-08
Identities = 51/201 (25%), Positives = 86/201 (42%), Gaps = 23/201 (11%)
Query: 331 MIIAVLILVAVVCLVTVCVIYRVDLVLFYR---------HLTRR--DETLTDGKTYDAFV 379
+I+ +++++ V+ L DL + R H R+ E L + AF+
Sbjct: 579 LIVTIVVIMLVLGLAVAFCCLHFDLPWYLRMLGQCTQTWHRVRKTTQEQLKRNVRFHAFI 638
Query: 380 SYLKECRPENGEEHTFAVEILPRVLEKHFGYKLCIFERDVVPGGAVVDEIHSLIEKSRRL 439
SY + + E++P + ++ +C++E PG ++ + I S IEKS +
Sbjct: 639 SYSEH------DSLWVKNELIPNLEKEDGSILICLYESYFDPGKSISENIVSFIEKSYKS 692
Query: 440 IIVLSKSYMSNE-VRYELESGLHEALVERKIKIILIEFTPVTDFTFLPQSLK---LLKSH 495
I VLS +++ NE YE H E IILI P+ + + K LL+
Sbjct: 693 IFVLSPNFVQNEWCHYEFYFAHHNLFHENSDHIILILLEPIPFYCIPTRYHKLKALLEKK 752
Query: 496 RVLKWKADKSLSYNSRFWKNL 516
L+W D+ FW NL
Sbjct: 753 AYLEWPKDRRKC--GLFWANL 771
>gi|62865618 toll-like receptor 10 precursor [Homo sapiens]
Length = 811
Score = 57.4 bits (137), Expect = 3e-08
Identities = 51/201 (25%), Positives = 86/201 (42%), Gaps = 23/201 (11%)
Query: 331 MIIAVLILVAVVCLVTVCVIYRVDLVLFYR---------HLTRR--DETLTDGKTYDAFV 379
+I+ +++++ V+ L DL + R H R+ E L + AF+
Sbjct: 579 LIVTIVVIMLVLGLAVAFCCLHFDLPWYLRMLGQCTQTWHRVRKTTQEQLKRNVRFHAFI 638
Query: 380 SYLKECRPENGEEHTFAVEILPRVLEKHFGYKLCIFERDVVPGGAVVDEIHSLIEKSRRL 439
SY + + E++P + ++ +C++E PG ++ + I S IEKS +
Sbjct: 639 SYSEH------DSLWVKNELIPNLEKEDGSILICLYESYFDPGKSISENIVSFIEKSYKS 692
Query: 440 IIVLSKSYMSNE-VRYELESGLHEALVERKIKIILIEFTPVTDFTFLPQSLK---LLKSH 495
I VLS +++ NE YE H E IILI P+ + + K LL+
Sbjct: 693 IFVLSPNFVQNEWCHYEFYFAHHNLFHENSDHIILILLEPIPFYCIPTRYHKLKALLEKK 752
Query: 496 RVLKWKADKSLSYNSRFWKNL 516
L+W D+ FW NL
Sbjct: 753 AYLEWPKDRRKC--GLFWANL 771
>gi|19924149 toll-like receptor 4 precursor [Homo sapiens]
Length = 839
Score = 52.8 bits (125), Expect = 8e-07
Identities = 54/193 (27%), Positives = 90/193 (46%), Gaps = 22/193 (11%)
Query: 332 IIAVLILVAVVCLVTVCVIYRVDLVLFYRHLTRRDETLTDGK---TYDAFVSYLKECRPE 388
II V +L +V V ++Y+ FY HL + G+ YDAFV Y +
Sbjct: 633 IIGVSVLSVLVVSVVAVLVYK-----FYFHLMLLAGCIKYGRGENIYDAFVIYSSQ---- 683
Query: 389 NGEEHTFAVEILPRVLEKHFGYKLCIFERDVVPGGAV-VDEIHSLIEKSRRLIIVLSKSY 447
+E E++ + E ++LC+ RD +PG A+ + IH KSR++I+V+S+ +
Sbjct: 684 --DEDWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIAANIIHEGFHKSRKVIVVVSQHF 741
Query: 448 M-SNEVRYELESGLHEALVERKIKIILIEFTPVTDFTFLPQSL---KLLKSHRVLKWKAD 503
+ S +E E + + II I V + T L Q + +LL + L+W +
Sbjct: 742 IQSRWCIFEYEIAQTWQFLSSRAGIIFIVLQKV-EKTLLRQQVELYRLLSRNTYLEW--E 798
Query: 504 KSLSYNSRFWKNL 516
S+ FW+ L
Sbjct: 799 DSVLGRHIFWRRL 811
>gi|27894334 interleukin 1 receptor, type II precursor [Homo
sapiens]
Length = 398
Score = 52.4 bits (124), Expect = 1e-06
Identities = 51/230 (22%), Positives = 91/230 (39%), Gaps = 27/230 (11%)
Query: 31 VEGEPFYLKHCS-------CSLAHEIETTTKSWYKSSGSQEHVELNPRSSSRIALHDCVL 83
+EGEP L+ C S++ I T W+K+ ++ + +R+ D L
Sbjct: 41 LEGEPVALR-CPQVPYWLWASVSPRINLT---WHKNDSART---VPGEEETRMWAQDGAL 93
Query: 84 EFWPVELNDTGSYFFQMKN--YTQKWKLNVIRRNKHSCFTERQVTSKIVEVKKFFQITCE 141
P D+G+Y +N Y K + + F +I+ + + C
Sbjct: 94 WLLPALQEDSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLVCP 153
Query: 142 NSY----------YQTLVNSTSLYKNCKKLLLENNKNPTIKKNAEFEDQGYYSCVHFLHH 191
+ Q +S L K+ +K L + + ED GYY CV H
Sbjct: 154 DLSEFTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAH 213
Query: 192 NGKLFNITKTFNITIVEDRSNIVPVLLGPKLNHVAVELGKNVRLNCSALL 241
G+ +NIT++ + I + + +PV++ P L ++ LG + + C L
Sbjct: 214 EGQQYNITRSIELRIKKKKEETIPVIISP-LKTISASLGSRLTIPCKVFL 262
>gi|4758598 interleukin 1 receptor, type II precursor [Homo sapiens]
Length = 398
Score = 52.4 bits (124), Expect = 1e-06
Identities = 51/230 (22%), Positives = 91/230 (39%), Gaps = 27/230 (11%)
Query: 31 VEGEPFYLKHCS-------CSLAHEIETTTKSWYKSSGSQEHVELNPRSSSRIALHDCVL 83
+EGEP L+ C S++ I T W+K+ ++ + +R+ D L
Sbjct: 41 LEGEPVALR-CPQVPYWLWASVSPRINLT---WHKNDSART---VPGEEETRMWAQDGAL 93
Query: 84 EFWPVELNDTGSYFFQMKN--YTQKWKLNVIRRNKHSCFTERQVTSKIVEVKKFFQITCE 141
P D+G+Y +N Y K + + F +I+ + + C
Sbjct: 94 WLLPALQEDSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLVCP 153
Query: 142 NSY----------YQTLVNSTSLYKNCKKLLLENNKNPTIKKNAEFEDQGYYSCVHFLHH 191
+ Q +S L K+ +K L + + ED GYY CV H
Sbjct: 154 DLSEFTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAH 213
Query: 192 NGKLFNITKTFNITIVEDRSNIVPVLLGPKLNHVAVELGKNVRLNCSALL 241
G+ +NIT++ + I + + +PV++ P L ++ LG + + C L
Sbjct: 214 EGQQYNITRSIELRIKKKKEETIPVIISP-LKTISASLGSRLTIPCKVFL 262
>gi|7706093 toll-like receptor 7 [Homo sapiens]
Length = 1049
Score = 49.3 bits (116), Expect = 9e-06
Identities = 48/193 (24%), Positives = 90/193 (46%), Gaps = 17/193 (8%)
Query: 333 IAVLILVAVVCLVTVCVIYRVDLVLFYRHLTRR----DETLTDGKTYDAFVSYLKECRPE 388
+++ + + ++ ++T +Y D+ Y + ++ YDAF+ Y + +
Sbjct: 845 LSISVSLFLMVMMTASHLYFWDVWYIYHFCKAKIKGYQRLISPDCCYDAFIVY--DTKDP 902
Query: 389 NGEEHTFA--VEILPRVLEKHFGYKLCIFERDVVPGGAVVDEIHSLIEKSRRLIIVLSKS 446
E A V L EKHF LC+ ERD +PG V++ + I+ S++ + V++
Sbjct: 903 AVTEWVLAELVAKLEDPREKHFN--LCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDK 960
Query: 447 YMSNEVRYELESGL-HEALVERKIKIILIEF--TPVTDFTFLPQSLKLLKSHRVLKWKAD 503
Y E +++ L H+ L++ K+ +I++ F P FL Q K L VL+W +
Sbjct: 961 YAKTE-NFKIAFYLSHQRLMDEKVDVIILIFLEKPFQKSKFL-QLRKRLCGSSVLEWPTN 1018
Query: 504 KSLSYNSRFWKNL 516
+ FW+ L
Sbjct: 1019 PQA--HPYFWQCL 1029
>gi|197276654 myeloid differentiation primary response gene 88 [Homo
sapiens]
Length = 309
Score = 47.0 bits (110), Expect = 4e-05
Identities = 35/117 (29%), Positives = 59/117 (50%), Gaps = 16/117 (13%)
Query: 375 YDAFVSYLKECRPENGEEHTFAVEILPRVLEKHFGYKLCIFERDVVPGGAVVDEIHSLIE 434
+DAF+ Y + F E++ ++ + ++ KLC+ +RDV+PG V LIE
Sbjct: 174 FDAFICYCPS-------DIQFVQEMIRQLEQTNYRLKLCVSDRDVLPGTCVWSIASELIE 226
Query: 435 K-SRRLIIVLSKSYM-SNEVRYE------LESGLHE-ALVERKIKIILIEFTPVTDF 482
K RR+++V+S Y+ S E ++ L G H+ L+ K K + EF + F
Sbjct: 227 KRCRRMVVVVSDDYLQSKECDFQTKFALSLSPGAHQKRLIPIKYKAMKKEFPSILRF 283
>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
[Homo sapiens]
Length = 1093
Score = 46.2 bits (108), Expect = 8e-05
Identities = 52/200 (26%), Positives = 86/200 (43%), Gaps = 30/200 (15%)
Query: 174 NAEFEDQGYYSCVHFLHHNGKLFNITKTFNITIVEDRSNIVPVLLGPKLNHVAVELGKNV 233
+ + +D G YSC +I+ +T++E S +VP L V +G+ V
Sbjct: 661 DVKIDDAGVYSCTA----QNSAGSISANATLTVLETPSLVVP------LEDRVVSVGETV 710
Query: 234 RLNCSALLNEEDVIYWMFGEENGSDPNIHEEKEMRIMTPEGKWHASKVLRIENIGESNLN 293
L C A N I W G+ S H +TP+ +++L ++N+ +
Sbjct: 711 ALQCKATGNPPPRITWFKGDRPLSLTERHH------LTPD-----NQLLVVQNVVAEDAG 759
Query: 294 VLYNCTVASTGGTD-TKSFILVRKADMADIPGH---VFTRGMIIAVLILVAVVCLVTVCV 349
Y C +++T GT+ S + V A G +FT IAV+ + + LV VC+
Sbjct: 760 -RYTCEMSNTLGTERAHSQLSVLPAAGCRKDGTTVGIFT----IAVVSSIVLTSLVWVCI 814
Query: 350 IYRVDLVLFYRHLTRRDETL 369
IY+ +T DET+
Sbjct: 815 IYQTRKKSEEYSVTNTDETV 834
>gi|20302168 toll-like receptor 8 [Homo sapiens]
Length = 1041
Score = 41.2 bits (95), Expect = 0.002
Identities = 48/176 (27%), Positives = 76/176 (43%), Gaps = 19/176 (10%)
Query: 347 VCVIYRVDL--VLFYRHLTRRDETLTDGKTYDAFVSYLKECRPENGEEHTFAVEILPRVL 404
V IY V L V YR L+ T YDA++SY ++ + + L L
Sbjct: 856 VWFIYNVCLAKVKGYRSLS------TSQTFYDAYISY----DTKDASVTDWVINELRYHL 905
Query: 405 E--KHFGYKLCIFERDVVPGGAVVDEIHSLIEKSRRLIIVLSKSYMSN-EVRYELESGLH 461
E + LC+ ERD PG A++D + I +S++ + VL+K Y + + L
Sbjct: 906 EESRDKNVLLCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKTAFYLALQ 965
Query: 462 EALVERKIKIILIEFTPVTDFT-FLPQSLKLLKSHRVLKWKADKSLSYNSRFWKNL 516
+ E II I PV + +L ++ KS +L+W + FW+ L
Sbjct: 966 RLMDENMDVIIFILLEPVLQHSQYLRLRQRICKS-SILQWPDNPKA--EGLFWQTL 1018
>gi|4507531 toll-like receptor 3 [Homo sapiens]
Length = 904
Score = 41.2 bits (95), Expect = 0.002
Identities = 25/99 (25%), Positives = 50/99 (50%), Gaps = 5/99 (5%)
Query: 411 KLCIFERDVVPGGAVVDEIHSLIEKSRRLIIVLSKSYMSNEV--RYELESGLHEALVERK 468
K C+ ERD G ++ I + I++SR++I V++ + + + R+++ + +A+ +
Sbjct: 785 KFCLEERDFEAGVFELEAIVNSIKRSRKIIFVITHHLLKDPLCKRFKVHHAVQQAIEQNL 844
Query: 469 IKIILIEFTPVTDFTF---LPQSLKLLKSHRVLKWKADK 504
IIL+ + D+ L + KSH +L W K
Sbjct: 845 DSIILVFLEEIPDYKLNHALCLRRGMFKSHCILNWPVQK 883
>gi|7662320 leucine-rich repeats and immunoglobulin-like domains 2
[Homo sapiens]
Length = 1065
Score = 39.3 bits (90), Expect = 0.009
Identities = 32/132 (24%), Positives = 59/132 (44%), Gaps = 18/132 (13%)
Query: 174 NAEFEDQGYYSCVHFLHHNGKLFNITKTFNITIVEDRSNIVPVLLGPKLNHVAVELGKNV 233
N F D+G Y C+ H N ++ +T+ N +P L ++ + + G
Sbjct: 569 NVNFTDEGKYQCIVTNHFGS---NYSQKAKLTV-----NEMPSFLKTPMD-LTIRTGAMA 619
Query: 234 RLNCSALLNEEDVIYWMFGEENGSDPNIHEEKEMRIMTPEGKWHASKVLRIENIGESNLN 293
RL C+A + I W ++ G+D E+ M +M + + + V +IE++G
Sbjct: 620 RLECAAEGHPAPQISWQ--KDGGTDFPAARERRMHVMPEDDVFFIANV-KIEDMG----- 671
Query: 294 VLYNCTVASTGG 305
+Y+C +T G
Sbjct: 672 -IYSCMAQNTAG 682
Score = 32.0 bits (71), Expect = 1.5
Identities = 47/199 (23%), Positives = 84/199 (42%), Gaps = 31/199 (15%)
Query: 174 NAEFEDQGYYSCVHFLHHNGKLFNITKTFNITIVEDRSNIVPVLLGPKLNHVAVELGKNV 233
N + ED G YSC+ G ++ ++T++E S I P L V G+
Sbjct: 664 NVKIEDMGIYSCMAQNTAGG----LSANASLTVLETPSFIRP------LEDKTVTRGETA 713
Query: 234 RLNCSALLNEEDVIYWMFGEENGSDPNIHEEKEMRIMTPEGKWHASKVLRIENIGESNLN 293
L C A + + W +++G P + E+ A+++L I + G +
Sbjct: 714 VLQCIAGGSPAPRLNWT--KDDG--PLLVTERHFFAA-------ANQLLIIVDAGLEDAG 762
Query: 294 VLYNCTVASTGGTDTKSFIL-VRKADMADIP----GHVFTRGMIIAVLILVAVVCLVTVC 348
Y C +++T GT+ L V + D GH + ++I+V V C+V
Sbjct: 763 -KYTCIMSNTLGTERGHIYLNVISSPNCDSSQSSIGHEDDGWTTVGIVIIVVVCCVVGTS 821
Query: 349 VIYRVDLVLFYRHLTRRDE 367
+I+ V+ H+ R++E
Sbjct: 822 LIW----VIVIYHMRRKNE 836
>gi|171460997 CD226 molecule precursor [Homo sapiens]
Length = 336
Score = 38.5 bits (88), Expect = 0.016
Identities = 50/203 (24%), Positives = 83/203 (40%), Gaps = 28/203 (13%)
Query: 163 LENNKNPTIKKNAEFEDQGYYSCVHFLHHNGKLFNITKTFNITIVEDRSNIVPVLLGPKL 222
+ +N +NA +D GYYSC + + G + I +V+ S V P
Sbjct: 86 MASNNMTLFFRNASEDDVGYYSCSLYTYPQGTWQKV-----IQVVQSDSFEAAV---PSN 137
Query: 223 NHVAVELGKNVRLNCSALLN-EEDVIYWMFGEENGSD----------PNIHEEKEMRIMT 271
+H+ E GKNV L C + + W + D N + +I++
Sbjct: 138 SHIVSEPGKNVTLTCQPQMTWPVQAVRWEKIQPRQIDLLTYCNLVHGRNFTSKFPRQIVS 197
Query: 272 --PEGKWHASKVLRIENIGESNLNVLYNCTV-ASTGGTDTKSFILVRKADMADIPGHVFT 328
G+W V+ I ++ S+ + LY C + AS G +T L D +F
Sbjct: 198 NCSHGRW---SVIVIPDVTVSD-SGLYRCYLQASAGENETFVMRLTVAEGKTDNQYTLFV 253
Query: 329 RGMIIAVLILVAVVCLVTVCVIY 351
G VL+L+ V+ + T+ VI+
Sbjct: 254 AGG--TVLLLLFVISITTIIVIF 274
>gi|13186249 fibroblast growth factor receptor 1 isoform 9 precursor
[Homo sapiens]
Length = 785
Score = 36.6 bits (83), Expect = 0.060
Identities = 42/183 (22%), Positives = 75/183 (40%), Gaps = 15/183 (8%)
Query: 179 DQGYYSCVHFLHHNGKLFNITKTFNITIVEDRSNIVPVLLGPKLNHVAVELGKNVRLNCS 238
D+G Y+C+ + +I T+ + +VE RS P+L + V LG NV C
Sbjct: 224 DKGNYTCIV----ENEYGSINHTYQLDVVE-RSPHRPILQAGLPANKTVALGSNVEFMCK 278
Query: 239 ALLNEEDVIYWM-FGEENGSDPNIHEEKEMRIMTPEGKWHASK---VLRIENIGESNLNV 294
+ + I W+ E NGS ++I+ G K VL + N+ +
Sbjct: 279 VYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGE 338
Query: 295 LYNCTVASTGGTDTKSFILVRKADMADIPGHVFTRGMIIAVLILVA----VVCLVTVCVI 350
Y C ++ G S L + + P V T + + ++I + C+V ++
Sbjct: 339 -YTCLAGNSIGLSHHSAWLTVLEALEERPA-VMTSPLYLEIIIYCTGAFLISCMVGSVIV 396
Query: 351 YRV 353
Y++
Sbjct: 397 YKM 399
>gi|13186236 fibroblast growth factor receptor 1 isoform 4 precursor
[Homo sapiens]
Length = 731
Score = 36.6 bits (83), Expect = 0.060
Identities = 42/183 (22%), Positives = 75/183 (40%), Gaps = 15/183 (8%)
Query: 179 DQGYYSCVHFLHHNGKLFNITKTFNITIVEDRSNIVPVLLGPKLNHVAVELGKNVRLNCS 238
D+G Y+C+ + +I T+ + +VE RS P+L + V LG NV C
Sbjct: 133 DKGNYTCIV----ENEYGSINHTYQLDVVE-RSPHRPILQAGLPANKTVALGSNVEFMCK 187
Query: 239 ALLNEEDVIYWM-FGEENGSDPNIHEEKEMRIMTPEGKWHASK---VLRIENIGESNLNV 294
+ + I W+ E NGS ++I+ G K VL + N+ +
Sbjct: 188 VYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGE 247
Query: 295 LYNCTVASTGGTDTKSFILVRKADMADIPGHVFTRGMIIAVLILVA----VVCLVTVCVI 350
Y C ++ G S L + + P V T + + ++I + C+V ++
Sbjct: 248 -YTCLAGNSIGLSHHSAWLTVLEALEERPA-VMTSPLYLEIIIYCTGAFLISCMVGSVIV 305
Query: 351 YRV 353
Y++
Sbjct: 306 YKM 308
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.408
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,544,428
Number of Sequences: 37866
Number of extensions: 905109
Number of successful extensions: 2393
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 29
Number of HSP's successfully gapped in prelim test: 58
Number of HSP's that attempted gapping in prelim test: 2254
Number of HSP's gapped (non-prelim): 165
length of query: 541
length of database: 18,247,518
effective HSP length: 107
effective length of query: 434
effective length of database: 14,195,856
effective search space: 6161001504
effective search space used: 6161001504
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.