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Search of human proteins with 4504487
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4504487 histidine rich calcium binding protein precursor
[Homo sapiens]
(699 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4504487 histidine rich calcium binding protein precursor [Hom... 1521 0.0
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 137 3e-32
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof... 103 7e-22
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens] 102 9e-22
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens] 101 2e-21
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof... 100 5e-21
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof... 100 6e-21
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof... 99 2e-20
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof... 98 3e-20
gi|24415404 MDN1, midasin homolog [Homo sapiens] 98 3e-20
gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens] 95 2e-19
gi|60097902 filaggrin [Homo sapiens] 95 3e-19
gi|217330641 IWS1 homolog [Homo sapiens] 89 1e-17
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 84 6e-16
gi|62122917 filaggrin family member 2 [Homo sapiens] 82 2e-15
gi|148746195 trichohyalin [Homo sapiens] 79 1e-14
gi|94536805 splicing factor YT521-B isoform 2 [Homo sapiens] 78 3e-14
gi|72534750 splicing factor YT521-B isoform 1 [Homo sapiens] 78 3e-14
gi|153251865 hypothetical protein LOC84226 [Homo sapiens] 77 4e-14
gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isof... 77 5e-14
gi|4758172 dentin matrix acidic phosphoprotein 1 isoform 1 precu... 75 2e-13
gi|20270337 Leo1, Paf1/RNA polymerase II complex component, homo... 73 8e-13
gi|221316599 chromogranin B precursor [Homo sapiens] 73 1e-12
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] 72 2e-12
gi|155030232 proline, glutamic acid and leucine rich protein 1 [... 71 4e-12
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 70 5e-12
gi|121256621 dentin matrix acidic phosphoprotein 1 isoform 2 pre... 70 9e-12
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 70 9e-12
gi|17975763 myelin transcription factor 1 [Homo sapiens] 69 1e-11
gi|100816397 MYST histone acetyltransferase (monocytic leukemia)... 69 1e-11
>gi|4504487 histidine rich calcium binding protein precursor [Homo
sapiens]
Length = 699
Score = 1521 bits (3938), Expect = 0.0
Identities = 699/699 (100%), Positives = 699/699 (100%)
Query: 1 MGHHRPWLHASVLWAGVASLLLPPAMTQQLRGDGLGFRNRNNSTGVAGLSEEASAELRHH 60
MGHHRPWLHASVLWAGVASLLLPPAMTQQLRGDGLGFRNRNNSTGVAGLSEEASAELRHH
Sbjct: 1 MGHHRPWLHASVLWAGVASLLLPPAMTQQLRGDGLGFRNRNNSTGVAGLSEEASAELRHH 60
Query: 61 LHSPRDHPDENKDVSTENGHHFWSHPDREKEDEDVSKEYGHLLPGHRSQDHKVGDEGVSG 120
LHSPRDHPDENKDVSTENGHHFWSHPDREKEDEDVSKEYGHLLPGHRSQDHKVGDEGVSG
Sbjct: 61 LHSPRDHPDENKDVSTENGHHFWSHPDREKEDEDVSKEYGHLLPGHRSQDHKVGDEGVSG 120
Query: 121 EEVFAEHGGQARGHRGHGSEDTEDSAEHRHHLPSHRSHSHQDEDEDEVVSSEHHHHILRH 180
EEVFAEHGGQARGHRGHGSEDTEDSAEHRHHLPSHRSHSHQDEDEDEVVSSEHHHHILRH
Sbjct: 121 EEVFAEHGGQARGHRGHGSEDTEDSAEHRHHLPSHRSHSHQDEDEDEVVSSEHHHHILRH 180
Query: 181 GHRGHDGEDDEGEEEEEEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRH 240
GHRGHDGEDDEGEEEEEEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRH
Sbjct: 181 GHRGHDGEDDEGEEEEEEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRH 240
Query: 241 QGHEEDDDDDDDDDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSH 300
QGHEEDDDDDDDDDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSH
Sbjct: 241 QGHEEDDDDDDDDDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSH 300
Query: 301 EEDDNDDDDVSTEYGHQAHRHQDHRKEEVEAVSGEHHHHVPDHRHQGHRDEEEDEDVSTE 360
EEDDNDDDDVSTEYGHQAHRHQDHRKEEVEAVSGEHHHHVPDHRHQGHRDEEEDEDVSTE
Sbjct: 301 EEDDNDDDDVSTEYGHQAHRHQDHRKEEVEAVSGEHHHHVPDHRHQGHRDEEEDEDVSTE 360
Query: 361 RWHQGPQHVHHGLVDEEEEEEEITVQFGHYVASHQPRGHKSDEEDFQDEYKTEVPHHHHH 420
RWHQGPQHVHHGLVDEEEEEEEITVQFGHYVASHQPRGHKSDEEDFQDEYKTEVPHHHHH
Sbjct: 361 RWHQGPQHVHHGLVDEEEEEEEITVQFGHYVASHQPRGHKSDEEDFQDEYKTEVPHHHHH 420
Query: 421 RVPREEDEEVSAELGHQAPSHRQSHQDEETGHGQRGSIKEMSHHPPGHTVVKDRSHLRKD 480
RVPREEDEEVSAELGHQAPSHRQSHQDEETGHGQRGSIKEMSHHPPGHTVVKDRSHLRKD
Sbjct: 421 RVPREEDEEVSAELGHQAPSHRQSHQDEETGHGQRGSIKEMSHHPPGHTVVKDRSHLRKD 480
Query: 481 DSEEEKEKEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEEEDK 540
DSEEEKEKEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEEEDK
Sbjct: 481 DSEEEKEKEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEEEDK 540
Query: 541 EEEEEEEDEERREERAEVGAPLSPDHSEEEEEEEEGLEEDEPRFTIIPNPLDRREEAGGA 600
EEEEEEEDEERREERAEVGAPLSPDHSEEEEEEEEGLEEDEPRFTIIPNPLDRREEAGGA
Sbjct: 541 EEEEEEEDEERREERAEVGAPLSPDHSEEEEEEEEGLEEDEPRFTIIPNPLDRREEAGGA 600
Query: 601 SSEEESGEDTGPQDAQEYGNYQPGSLCGYCSFCNRCTECESCHCDEENMGEHCDQCQHCQ 660
SSEEESGEDTGPQDAQEYGNYQPGSLCGYCSFCNRCTECESCHCDEENMGEHCDQCQHCQ
Sbjct: 601 SSEEESGEDTGPQDAQEYGNYQPGSLCGYCSFCNRCTECESCHCDEENMGEHCDQCQHCQ 660
Query: 661 FCYLCPLVCETVCAPGSYVDYFSSSLYQALADMLETPEP 699
FCYLCPLVCETVCAPGSYVDYFSSSLYQALADMLETPEP
Sbjct: 661 FCYLCPLVCETVCAPGSYVDYFSSSLYQALADMLETPEP 699
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 137 bits (346), Expect = 3e-32
Identities = 139/538 (25%), Positives = 204/538 (37%), Gaps = 90/538 (16%)
Query: 87 DREKEDEDVSKEYGHLLPGHRSQDHKVGDEGVSGEEVFAEHGGQARGHRGHGSEDTEDSA 146
D+ + E +K G G + +EG SG E + + + +G + G + E
Sbjct: 632 DKAEVSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEERE-KGEKDKGRGEMERPG 690
Query: 147 EHRHHLPSHRSHSHQDEDEDEVVSSEHHHHILRHGHRGHDGEDDEGEEEEEEEEEEEEAS 206
E L +D +E E E H R+ GE++ GE EEEE + EEE
Sbjct: 691 EGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEE 750
Query: 207 TEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEEDDDDDDDDDDDDDDDDVSIEY 266
E G G EE E G G + +G + ++ ++ +++ D
Sbjct: 751 KE---------GEGKEEGE----GEEVEGEREKEEGERKKEERAGKEEKGEEEGD----- 792
Query: 267 RHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSHEEDDNDDDDVSTEYGHQAHRHQDHRK 326
QG G EE+ + R E+++ + + G + + R+
Sbjct: 793 -------QGEGEEEETE-------------GRGEEKEEGGEVE-----GGEVEEGKGERE 827
Query: 327 EEVEAVSGEHHHHVPDHRHQGHRDEEEDEDVSTERWHQGPQHVHHGLVDEEEEEEEITVQ 386
EE E GE +G +EEE E E +G + G +EE EE E
Sbjct: 828 EEEEEGEGEEE--------EGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGE---- 875
Query: 387 FGHYVASHQPRGHKSDEEDFQDEYKTEVPHHHHHRVPREEDEEVSAE-LGHQAPSHRQSH 445
+ G EE+ + E + E E EE E G + +
Sbjct: 876 ----GEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGE 931
Query: 446 QDEETGHGQRGSIKEMSHHPPGHTVVKDRSHLRKDDSEEEKEKEEDPGSHEEDDESSEQG 505
+EE G G+ +D E E E+EE EE++ E
Sbjct: 932 GEEEEGEGEG------------------------EDGEGEGEEEEGEWEGEEEEGEGEGE 967
Query: 506 EKGTHHGSRDQ-EDEEDEEEGHGLSLNQEEEEEEDKEEEEEEEDEERREERAEVGAPLSP 564
E+G G + E EE+E EG G EEE EE+ E EEE E E EE EV +
Sbjct: 968 EEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEG 1027
Query: 565 DHSEEEEEEEEGLEEDEPRFTI---IPNPLDRREEAGGASSEEESGEDTGP-QDAQEY 618
+ E E EEEEG EE E R N +R EE +E+GE+ QD +EY
Sbjct: 1028 EEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEEENERQDGEEY 1085
Score = 108 bits (271), Expect = 1e-23
Identities = 114/453 (25%), Positives = 175/453 (38%), Gaps = 59/453 (13%)
Query: 188 EDDEGEEEEEEEEEEEEASTEYGHQAHRHRGHGSEED----EDVSDG------HHHHGPS 237
ED +G EE+E E E + + H + + +D +VS+G GP
Sbjct: 594 EDSKGNGIEEQEVEANEENVKV-HGGRKEKTEILSDDLTDKAEVSEGKAKSVGEAEDGPE 652
Query: 238 HRHQGHEEDDDDDDDDDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDGHHHRDPSHRH 297
R G E+ + D++ R + + +G G E G ++ + +
Sbjct: 653 GRGDGTCEEGSSGAEHWQDEE--------REKGEKDKGRGEME----RPGEGEKELAEKE 700
Query: 298 RSHEEDDNDDDDVSTEYGHQAHRHQDHRKEEVEAVSGEHHHHVPDHRHQGHRDEEEDEDV 357
+ D + + E GHQ R+Q E G H +G R+EEE+++
Sbjct: 701 EWKKRDGEEQEQKEREQGHQKERNQ-------EMEEGGEEEHGEGEEEEGDREEEEEKEG 753
Query: 358 STERWHQGPQHVHHGLVDEEEEEEEITVQFGHYVASHQPRGHKSDEEDFQDEYKTEVPHH 417
+ +G + V+ E E+EE + A + +G + ++ +E +TE
Sbjct: 754 EGKEEGEGEE------VEGEREKEE-GERKKEERAGKEEKGEEEGDQGEGEEEETEGRGE 806
Query: 418 HHHRVPREEDEEVSAELGHQAPSHRQSHQDEETGHGQRGSIKEMSHHPPGHTVVKDRSHL 477
E EV G + + +EE G G+ + G +
Sbjct: 807 EKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEG------KGEE 860
Query: 478 RKDDSEEEKEKEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEE 537
++ E E+E EE G EE++ E E+G G ++ + E EEEG G EEEE
Sbjct: 861 EGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEG---EGEEEEG 917
Query: 538 EDKEEEEEEEDE-ERREERAEVGAPLSPDHSEEEE-----EEEEGLEEDEPRFTIIPNPL 591
E K EEE EE E E EE E EEEE EEEEG E E
Sbjct: 918 EGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEG------- 970
Query: 592 DRREEAGGASSEEESGEDTGPQDAQEYGNYQPG 624
+ E G EEE GE G ++ E + G
Sbjct: 971 EGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEG 1003
Score = 91.3 bits (225), Expect = 3e-18
Identities = 100/478 (20%), Positives = 179/478 (37%), Gaps = 75/478 (15%)
Query: 66 DHPDENKDVSTENGH---HFWSHPDREKEDEDVSKEYGHL-LPGHRSQDHKVGDEGVSGE 121
D P+ D + E G W +REK ++D K G + PG ++ +E +
Sbjct: 649 DGPEGRGDGTCEEGSSGAEHWQDEEREKGEKD--KGRGEMERPGEGEKELAEKEEWKKRD 706
Query: 122 EVFAEHGGQARGHRGHGSEDTEDSAEHRHHLPSHRSHSHQDEDEDEVVSSEHHHHILRHG 181
E + +GH+ +++ E+ E H ++E+E E E G
Sbjct: 707 GEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEG 766
Query: 182 HRGHD----------GEDDEGEEE------EEEE-----EEEEEASTEYGHQAHRHRGHG 220
R + G++++GEEE EEEE EE+EE G + +G
Sbjct: 767 EREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGER 826
Query: 221 SEEDEDVSDGHHHHGPSHRHQGHEEDDD-----DDDDDDDDDDDDDVSIEYRHQAHRHQG 275
EE+E+ +G G +G E+++ +++ ++ + +++ E + +G
Sbjct: 827 EEEEEE-GEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEG 885
Query: 276 HGIEEDEDVSDGHHHRDPSHRHRSHEEDDNDDDDVSTEYGHQAHRHQDHRKEEVEAVSGE 335
G EE E + E ++ + + E G + + + E E GE
Sbjct: 886 EGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGE 945
Query: 336 HHHHVPDHRHQGHRDE------EEDEDVSTERWHQGPQHVHHGLVDEEEEEEEITVQFGH 389
+ +G +E EE E E +G + G +EEE EEE G
Sbjct: 946 GEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEE-----GE 1000
Query: 390 YVASHQPRGHKSDEEDFQDEYKTEVPHHHHHRVPREEDEEVSAELGHQAPSHRQSHQDEE 449
+ G EE+ + E + EV E EE E G + + + E+
Sbjct: 1001 EEGEGEEEGEGEGEEEEEGEVEGEV-----------EGEEGEGE-GEEEEGEEEGEEREK 1048
Query: 450 TGHGQRGSIKEMSHHPPGHTVVKDRSHLRKDDSEEEKEKEEDPGSHEEDDESSEQGEK 507
G G+ + R+++ EEE K ++ G E + + E+ +K
Sbjct: 1049 EGEGE------------------ENRRNREEEEEEE-GKYQETGEEENERQDGEEYKK 1087
Score = 89.4 bits (220), Expect = 1e-17
Identities = 99/422 (23%), Positives = 165/422 (39%), Gaps = 38/422 (9%)
Query: 51 EEASAELRHHLHSPRDHPDENKDVSTENGHHFWSHPDREKEDEDVS--KEYGHLLPGHRS 108
EE + R H + + + E+G DRE+E+E KE G G
Sbjct: 708 EEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGE---GEEV 764
Query: 109 QDHKVGDEGVSGEEVFA--EHGGQARGHRGHGSED-TEDSAEHRHHLPSHRSHSHQDEDE 165
+ + +EG +E A E G+ G +G G E+ TE E + E+
Sbjct: 765 EGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEK-------------EEG 811
Query: 166 DEVVSSEHHHHILRHGHRGHDGEDDEGEEEEEEEEEEE-EASTEYGHQAHRHRGHGSEED 224
EV E G R + E+ EGEEEE E EEEE E E G G EE
Sbjct: 812 GEVEGGEVEEG---KGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEG---EEG 865
Query: 225 EDVSDGHHHHGPSHRHQGH---EEDDDDDDDDDDDDDDDDVSIEYRHQAHRHQGHGIEED 281
E +G G +G EE+ + + ++++ + + + E + +G G EE
Sbjct: 866 EGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEG 925
Query: 282 EDVSDGHHHRDPSHRHRSHEEDDNDDDDVSTEYGHQAHRHQDHRKEEVEAVSGEHHHHVP 341
E+ G + E+ + + ++ E+ + + +EE E E
Sbjct: 926 EE---GEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGE 982
Query: 342 DHRHQGHRDEEEDEDVSTERWHQGPQHVHHGLVDEEEEEEEITVQFGHYVASHQPRGHKS 401
+ +G +EEE E+ E + G EEEEE E+ + + +
Sbjct: 983 EEEGEGEGEEEEGEEEGEEEGEGEEEGEGEG---EEEEEGEVEGEVEGEEGEGEGEEEEG 1039
Query: 402 DEEDFQDEYKTEVPHHHHHRVPREEDEEVSAELGHQAPSHRQSHQDEETGHGQRGSIKEM 461
+EE + E + E + +R EE+EE + + + RQ ++ + +GS+K
Sbjct: 1040 EEEGEEREKEGEGEENRRNR-EEEEEEEGKYQETGEEENERQDGEEYKKVSKIKGSVKYG 1098
Query: 462 SH 463
H
Sbjct: 1099 KH 1100
Score = 64.3 bits (155), Expect = 4e-10
Identities = 72/293 (24%), Positives = 123/293 (41%), Gaps = 32/293 (10%)
Query: 350 DEEEDEDVSTERWHQG-PQHVHHGL-------VDEEEEEEEITVQFGHYVASHQPRGHKS 401
D +E E++S + + QHV G+ E +EE+ + + +G+
Sbjct: 543 DSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFSDEEVEIP-EEKEGAEDSKGNGI 601
Query: 402 DEEDFQ-DEYKTEVPHHHHHRVPREEDEEVSAELGHQAPSHRQSHQDEETGHGQRGSIKE 460
+E++ + +E +V H +E+ E +S +L +A E G+ S+ E
Sbjct: 602 EEQEVEANEENVKV-----HGGRKEKTEILSDDLTDKA----------EVSEGKAKSVGE 646
Query: 461 MSHHPPGH---TVVKDRSHLR--KDDSEEEKEKEEDPGSHEEDDESSEQGEKGTHHGSRD 515
P G T + S +D+ E+ EK++ G E E ++ + RD
Sbjct: 647 AEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRD 706
Query: 516 QEDEE--DEEEGHGLSLNQEEEEEEDKEEEEEEEDEERREERAEVGAPLSPDHSEEEEEE 573
E++E + E+GH NQE EE ++E E EE+E REE E + EE E
Sbjct: 707 GEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEG 766
Query: 574 EEGLEEDEPRFTIIPNPLDRREEAGGASSEEESGEDTGPQDAQEYGNYQPGSL 626
E EE E + ++ EE G EE + ++ +E G + G +
Sbjct: 767 EREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEV 819
>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
2 [Homo sapiens]
Length = 782
Score = 103 bits (256), Expect = 7e-22
Identities = 105/434 (24%), Positives = 178/434 (41%), Gaps = 56/434 (12%)
Query: 193 EEEEEEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEEDDDDDDD 252
E++ +E+EE+ + R S E+ ++ D H + R+ + +D +D
Sbjct: 19 EKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRD--HRMEITIRNSPYRREDSMEDR 76
Query: 253 DDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSHEEDDNDDDDVST 312
++DD ++I+ Q R + +DE R RHRSH + V
Sbjct: 77 GEEDDS---LAIKPPQQMSRKEKVHHRKDEK-------RKEKRRHRSHSAEGGKHARVKE 126
Query: 313 EYGHQAHRHQDHRKEEVEAVSGEHHHHVPDHRHQGHRDEEEDEDVSTERWHQGPQHVHHG 372
+ + H + +EE + E + H E D ER + + +
Sbjct: 127 K--EREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQ 184
Query: 373 LVDEEEEEEEITVQFGHYVASHQPRGHKSDEEDFQDEYKTEVPHHHHHRVPREE-DEEVS 431
++ E++E R +++E + E + EV HH R RE+ ++V
Sbjct: 185 QKEQREQKE---------------RERRAEERRKEREARREVSAHH--RTMREDYSDKVK 227
Query: 432 AELGHQAPSHRQSHQDEETGHGQRGSIKEMSHHPPGHTVVKDRSHLRKDDSEEEKEKEED 491
A ++P R + E G G++ P +++R L D ++ + E
Sbjct: 228 ASHWSRSPP-RPPRERFELGDGRK---------PVKEEKMEERDLL--SDLQDISDSERK 275
Query: 492 PGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEEEDKEEEEEEEDEER 551
S E S+E G GS ++E+EE+EEE G + EE ++EEEEEEE+EE
Sbjct: 276 TSSAESS--SAESGS-----GSEEEEEEEEEEEEEGST-----SEESEEEEEEEEEEEEE 323
Query: 552 REERAEVGAPLSPDHSEEEEEEEEGLEEDEPRFTIIPNPLDRREEAGGASSEEESGEDTG 611
+E + S + EEE E+ E+E ++P R+ +EEE GE T
Sbjct: 324 TGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTP 383
Query: 612 PQDAQEYGNYQPGS 625
A G+Y P S
Sbjct: 384 QSSALTEGDYVPDS 397
Score = 47.8 bits (112), Expect = 4e-05
Identities = 26/100 (26%), Positives = 48/100 (48%), Gaps = 3/100 (3%)
Query: 188 EDDEGEEEEEEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEEDD 247
E G EEEEEEEEEEE E G + EE+E+ + + + E +
Sbjct: 285 ESGSGSEEEEEEEEEEE---EEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSE 341
Query: 248 DDDDDDDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDG 287
++ +D++ ++++ + + + R G E +E+V +G
Sbjct: 342 EEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEG 381
Score = 45.8 bits (107), Expect = 1e-04
Identities = 70/328 (21%), Positives = 104/328 (31%), Gaps = 59/328 (17%)
Query: 84 SHPDREKEDEDVSKEYGHLLPGHRSQDHKVGDEGVSGEEVFAEHGGQARGHRGHGSEDTE 143
S DR +ED+ ++ + P S+ KV + H R H G +
Sbjct: 72 SMEDRGEEDDSLAIKP----PQQMSRKEKVHHRKDEKRKEKRRH----RSHSAEGGKHAR 123
Query: 144 DSAEHRHHLPSHRSHSHQDEDEDEVVSSEHHHHILRHGHRGHD----------------- 186
+ R H R QD+ E + H R D
Sbjct: 124 VKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMRE 183
Query: 187 -----GEDDEGEEEEEEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSH--- 238
E E E EE +E EA E AH HR + + V H P
Sbjct: 184 QQKEQREQKERERRAEERRKEREARREV--SAH-HRTMREDYSDKVKASHWSRSPPRPPR 240
Query: 239 --------RHQGHEEDDDDDD--DDDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDGH 288
R EE ++ D D D D + + G G EE+E+ +
Sbjct: 241 ERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEE 300
Query: 289 HHRDPSHRHRSHEEDDNDDDDVSTEYGHQAHRHQDHRKEEV------EAVSGEHHHH--- 339
+ EE++ ++++ T G + + EEV E E+ +H
Sbjct: 301 EEEGSTSEESEEEEEEEEEEEEET--GSNSEEASEQSAEEVSEEEMSEDEERENENHLLV 358
Query: 340 VPDHRHQGHRDEEEDEDVSTERWHQGPQ 367
VP+ R RD E E+ E PQ
Sbjct: 359 VPESRFD--RDSGESEEAEEEVGEGTPQ 384
Score = 36.2 bits (82), Expect = 0.11
Identities = 38/159 (23%), Positives = 59/159 (37%), Gaps = 22/159 (13%)
Query: 51 EEASAELRHHLHSPRDHPDENKDVSTENGHHFWSHPDREKEDEDVSKEYGHLLPGHRSQD 110
+E E R L +D D + S+ S E+E+E+ +E
Sbjct: 253 KEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEE----------- 301
Query: 111 HKVGDEGVSGEEVFAEHGGQARGHRGHGSEDTEDSAEHRHHLPSHRSHSHQDEDEDEVVS 170
+EG + EE E + GS E S + + S ++ EDE
Sbjct: 302 ----EEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEV------SEEEMSEDEERE 351
Query: 171 SEHHHHILRHGHRGHD-GEDDEGEEEEEEEEEEEEASTE 208
+E+H ++ D GE +E EEE E + A TE
Sbjct: 352 NENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTE 390
>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
Length = 780
Score = 102 bits (255), Expect = 9e-22
Identities = 91/353 (25%), Positives = 141/353 (39%), Gaps = 43/353 (12%)
Query: 293 PSHRHRSHEEDDNDDDDVSTEYGHQAHRHQD--HRKEEVEAVSGEHHHH---------VP 341
P R S E+ +DD ++ + Q R + HRK+E HH H V
Sbjct: 66 PYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKCRHHSHSAEGGKHARVK 125
Query: 342 DHRHQGHRDEEEDEDVSTERWHQGPQHVHHGLVDEEEEEEEITVQFGHYVASHQPRGHKS 401
+ H+ + E++D + W + + + E E ++ + + +
Sbjct: 126 EREHERRKRHREEQDKARREWERQKRRE---MAREHSRRERDRLEQLERKRERERKMREQ 182
Query: 402 DEEDFQDEYKTEVPHHHHHRVPREEDEEVSAELGHQAPSHRQSHQDEETGHGQRGSIKEM 461
+E Q E K R RE EVSA HR +D + +
Sbjct: 183 QKE--QREQKERERRAEERRKEREARREVSAH-------HRTMRED----YSDKVKASHW 229
Query: 462 SHHPPGHTVVKDRSHL---RKDDSEEEKEKEE------DPGSHEEDDESSEQGEKGTHHG 512
S PP ++R L RK EE+ E+ + D E S+E + G
Sbjct: 230 SRSPPRPP--RERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSG 287
Query: 513 SRDQEDEEDEEEGHGLSLNQEEEEEEDKEEEEEEEDEERREERAEVGAPLSPDHSEEEEE 572
S ++E+EE+EEE G + EE ++EEEEEEE+EE +E + S + EEE
Sbjct: 288 SEEEEEEEEEEEEEGST-----SEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEM 342
Query: 573 EEEGLEEDEPRFTIIPNPLDRREEAGGASSEEESGEDTGPQDAQEYGNYQPGS 625
E+ E+E ++P R+ +EEE GE T A G+Y P S
Sbjct: 343 SEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDS 395
Score = 47.8 bits (112), Expect = 4e-05
Identities = 26/100 (26%), Positives = 48/100 (48%), Gaps = 3/100 (3%)
Query: 188 EDDEGEEEEEEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEEDD 247
E G EEEEEEEEEEE E G + EE+E+ + + + E +
Sbjct: 283 ESGSGSEEEEEEEEEEE---EEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSE 339
Query: 248 DDDDDDDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDG 287
++ +D++ ++++ + + + R G E +E+V +G
Sbjct: 340 EEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEG 379
Score = 45.8 bits (107), Expect = 1e-04
Identities = 65/319 (20%), Positives = 104/319 (32%), Gaps = 43/319 (13%)
Query: 84 SHPDREKEDEDVSKEYGHLLPGHRSQDHKVGDEGVSGEEVFAEHGGQARGHRGHGSEDTE 143
S DR +ED+ ++ + + H+ ++ +E H A G + ++ E
Sbjct: 72 SMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKR---KEKCRHHSHSAEGGKHARVKERE 128
Query: 144 DSAEHRHHLPSH---------------RSHSHQDEDEDEVVSSEHHHHILRHGHRGHDGE 188
RH R HS ++ D E + + + E
Sbjct: 129 HERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQRE 188
Query: 189 DDEGEEEEEEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSH---------- 238
E E EE +E EA E AH HR + + V H P
Sbjct: 189 QKERERRAEERRKEREARREVS--AH-HRTMREDYSDKVKASHWSRSPPRPPRERFELGD 245
Query: 239 -RHQGHEEDDDDDD--DDDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDV-----SDGHHH 290
R EE ++ D D D D + + G G EE+E+ +G
Sbjct: 246 GRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTS 305
Query: 291 RDPSHRHRSHEEDDNDDDDVSTEYGHQAHRH--QDHRKEEVEAVSGEHHHHVPDHRHQGH 348
+ EE++ + S E Q+ ++ E+ E + H VP+ R
Sbjct: 306 EESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFD-- 363
Query: 349 RDEEEDEDVSTERWHQGPQ 367
RD E E+ E PQ
Sbjct: 364 RDSGESEEAEEEVGEGTPQ 382
Score = 36.2 bits (82), Expect = 0.11
Identities = 38/159 (23%), Positives = 59/159 (37%), Gaps = 22/159 (13%)
Query: 51 EEASAELRHHLHSPRDHPDENKDVSTENGHHFWSHPDREKEDEDVSKEYGHLLPGHRSQD 110
+E E R L +D D + S+ S E+E+E+ +E
Sbjct: 251 KEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEE----------- 299
Query: 111 HKVGDEGVSGEEVFAEHGGQARGHRGHGSEDTEDSAEHRHHLPSHRSHSHQDEDEDEVVS 170
+EG + EE E + GS E S + + S ++ EDE
Sbjct: 300 ----EEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEV------SEEEMSEDEERE 349
Query: 171 SEHHHHILRHGHRGHD-GEDDEGEEEEEEEEEEEEASTE 208
+E+H ++ D GE +E EEE E + A TE
Sbjct: 350 NENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTE 388
>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
Length = 770
Score = 101 bits (252), Expect = 2e-21
Identities = 104/434 (23%), Positives = 167/434 (38%), Gaps = 68/434 (15%)
Query: 193 EEEEEEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEEDDDDDDD 252
E++ +E+EE+ + R S E+ ++ D H + R+ + +D +D
Sbjct: 19 EKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRD--HCMEITIRNSPYRREDSMEDR 76
Query: 253 DDDDDDDDDVSIEYRHQAHRHQG-HGIEEDEDVSDGHHHRDPSHRHRSHEEDDNDDDDVS 311
++D D ++I+ Q R + H ++++ H R H + + D
Sbjct: 77 GEED---DSLAIKPPQQMSRKEKVHHRKDEKRKEKWKHARVKEREHERRKRHREEQDKAR 133
Query: 312 TEYGHQAHRHQDHRKEEVEAVSGEHHHHVPDHRHQGHRDEEEDEDVSTERWHQGPQHVHH 371
E+ Q R ++ EH D Q R E + + ++ Q Q
Sbjct: 134 REWERQKRRE----------MAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERE 183
Query: 372 GLVDEEEEEEEITVQFGHYVASHQPRGHKSDEEDFQDEYKTEVPHHHHHRVPREEDEEVS 431
+E +E E + V++H H++ ED+ D+ K R PRE
Sbjct: 184 RRAEERRKEREARRE----VSAH----HRTMREDYSDKVKASHWSRSPPRPPRER----- 230
Query: 432 AELGHQAPSHRQSHQDEETGHGQRGSIKEMSHHPPGHTVVKDRSHLRKDDSEEEKEKEED 491
ELG ++ +E I + RK S E E
Sbjct: 231 FELGDGRKPVKEEKMEERDLLSDLQDISDSE---------------RKTSSAESSSAESG 275
Query: 492 PGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEEEDKEEEEEEEDEER 551
GS EE++E +EE+EEEG S ++E EEEE++EEEEEEE
Sbjct: 276 SGSEEEEEE-----------------EEEEEEEG---STSEESEEEEEEEEEEEEETGSN 315
Query: 552 REERAEVGAPLSPDHSEEEEEEEEGLEEDEPRFTIIPNPLDRREEAGGASSEEESGEDTG 611
EE +E A + EEE E+ E+E ++P R+ +EEE GE T
Sbjct: 316 SEEASEQSA----EEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTP 371
Query: 612 PQDAQEYGNYQPGS 625
A G+Y P S
Sbjct: 372 QSSALTEGDYVPDS 385
Score = 50.1 bits (118), Expect = 7e-06
Identities = 66/310 (21%), Positives = 106/310 (34%), Gaps = 35/310 (11%)
Query: 84 SHPDREKEDEDVS----KEYGHLLPGHRSQDHKVGDEGVSGEEVFAEHGGQARGHRGHGS 139
S DR +ED+ ++ ++ H +D K ++ EH + R
Sbjct: 72 SMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKWKHARVKEREHERRKRHREEQDK 131
Query: 140 EDTEDSAEHRHHLPSHRSHSHQDEDEDEVVSSEHHHHILRHGHRGHDGEDDEGEEEEEEE 199
E + R + R HS ++ D E + + + E E E EE
Sbjct: 132 ARREWERQKRREMA--REHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEER 189
Query: 200 EEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSH-----------RHQGHEEDDD 248
+E EA E AH HR + + V H P R EE +
Sbjct: 190 RKEREARREVS--AH-HRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKME 246
Query: 249 DDD--DDDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSHEEDDND 306
+ D D D D + + G G EE+E+ + + EE++ +
Sbjct: 247 ERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEE 306
Query: 307 DDDVSTEYGHQAHRHQDHRKEEV------EAVSGEHHHH---VPDHRHQGHRDEEEDEDV 357
+++ T G + + EEV E E+ +H VP+ R RD E E+
Sbjct: 307 EEEEET--GSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFD--RDSGESEEA 362
Query: 358 STERWHQGPQ 367
E PQ
Sbjct: 363 EEEVGEGTPQ 372
Score = 36.2 bits (82), Expect = 0.11
Identities = 38/159 (23%), Positives = 59/159 (37%), Gaps = 22/159 (13%)
Query: 51 EEASAELRHHLHSPRDHPDENKDVSTENGHHFWSHPDREKEDEDVSKEYGHLLPGHRSQD 110
+E E R L +D D + S+ S E+E+E+ +E
Sbjct: 241 KEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEE----------- 289
Query: 111 HKVGDEGVSGEEVFAEHGGQARGHRGHGSEDTEDSAEHRHHLPSHRSHSHQDEDEDEVVS 170
+EG + EE E + GS E S + + S ++ EDE
Sbjct: 290 ----EEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEV------SEEEMSEDEERE 339
Query: 171 SEHHHHILRHGHRGHD-GEDDEGEEEEEEEEEEEEASTE 208
+E+H ++ D GE +E EEE E + A TE
Sbjct: 340 NENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTE 378
>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
4 [Homo sapiens]
Length = 737
Score = 100 bits (249), Expect = 5e-21
Identities = 95/379 (25%), Positives = 145/379 (38%), Gaps = 64/379 (16%)
Query: 249 DDDDDDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDGHHHR--DPSHRHRSHEEDDND 306
+D +D ++DD ++I+ Q R + +DE + H R + H + +
Sbjct: 36 EDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREE 95
Query: 307 DDDVSTEYGHQAHRHQDHRKEEVEAVSGEHHHHVPDHRHQGHRDEEEDEDVSTERWHQGP 366
D E+ Q R ++ EH D Q R E + + ++ Q
Sbjct: 96 QDKARREWERQKRRE----------MAREHSRRERDRLEQLERKRERERKMREQQKEQRE 145
Query: 367 QHVHHGLVDEEEEEEEITVQFGHYVASHQPRGHKSDEEDFQDEYKTEVPHHHHHRVPREE 426
Q +E +E E + V++H H++ ED+ D+ K R PRE
Sbjct: 146 QKERERRAEERRKEREARRE----VSAH----HRTMREDYSDKVKASHWSRSPPRPPRER 197
Query: 427 DEEVSAELGHQAPSHRQSHQDEETGHGQRGSIKEMSHHPPGHTVVKDRSHLRKDDSEEEK 486
ELG ++ +E I + RK S E
Sbjct: 198 -----FELGDGRKPVKEEKMEERDLLSDLQDISDSE---------------RKTSSAESS 237
Query: 487 EKEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEEEDKEEEEEE 546
E GS EE++E +EE+EEEG S ++E EEEE++EEEEEE
Sbjct: 238 SAESGSGSEEEEEE-----------------EEEEEEEG---STSEESEEEEEEEEEEEE 277
Query: 547 EDEERREERAEVGAPLSPDHSEEEEEEEEGLEEDEPRFTIIPNPLDRREEAGGASSEEES 606
E EE +E A + EEE E+ E+E ++P R+ +EEE
Sbjct: 278 ETGSNSEEASEQSA----EEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEV 333
Query: 607 GEDTGPQDAQEYGNYQPGS 625
GE T A G+Y P S
Sbjct: 334 GEGTPQSSALTEGDYVPDS 352
Score = 50.8 bits (120), Expect = 4e-06
Identities = 69/315 (21%), Positives = 108/315 (34%), Gaps = 44/315 (13%)
Query: 84 SHPDREKEDEDVS---------KEYGHLLPGHRSQDHKVGDEGVSGEEVFAEHGGQARGH 134
S DR +ED+ ++ KE H HR + + + +E EH + R
Sbjct: 38 SMEDRGEEDDSLAIKPPQQMSRKEKVH----HRKDEKRKEKKHARVKEKEREHERRKRHR 93
Query: 135 RGHGSEDTEDSAEHRHHLPSHRSHSHQDEDEDEVVSSEHHHHILRHGHRGHDGEDDEGEE 194
E + R + R HS ++ D E + + + E E E
Sbjct: 94 EEQDKARREWERQKRREMA--REHSRRERDRLEQLERKRERERKMREQQKEQREQKERER 151
Query: 195 EEEEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSH-----------RHQGH 243
EE +E EA E AH HR + + V H P R
Sbjct: 152 RAEERRKEREARREVS--AH-HRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVK 208
Query: 244 EEDDDDDD--DDDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSHE 301
EE ++ D D D D + + G G EE+E+ + + E
Sbjct: 209 EEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEE 268
Query: 302 EDDNDDDDVSTEYGHQAHRHQDHRKEEV------EAVSGEHHHH---VPDHRHQGHRDEE 352
E++ ++++ T G + + EEV E E+ +H VP+ R RD
Sbjct: 269 EEEEEEEEEET--GSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFD--RDSG 324
Query: 353 EDEDVSTERWHQGPQ 367
E E+ E PQ
Sbjct: 325 ESEEAEEEVGEGTPQ 339
Score = 49.3 bits (116), Expect = 1e-05
Identities = 33/130 (25%), Positives = 65/130 (50%), Gaps = 7/130 (5%)
Query: 454 QRGSIKEMSHHPPGHTVVKDRSHLRKDDSEEEKEKEEDPGSHEEDDESSEQGEKGTHHGS 513
+R S++E + S R++DS E++ +E+D + + + S + + HH
Sbjct: 10 KRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEK--VHH-- 65
Query: 514 RDQEDEEDEEEGHGLSLNQEEEEEEDKEEEEEEEDEERREERAEVGAPLSPDHSEEEEEE 573
++DE+ +E+ H + ++E E E ++ EE+D+ RRE + ++ +HS E +
Sbjct: 66 --RKDEKRKEKKHA-RVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDR 122
Query: 574 EEGLEEDEPR 583
E LE R
Sbjct: 123 LEQLERKRER 132
Score = 36.2 bits (82), Expect = 0.11
Identities = 38/159 (23%), Positives = 59/159 (37%), Gaps = 22/159 (13%)
Query: 51 EEASAELRHHLHSPRDHPDENKDVSTENGHHFWSHPDREKEDEDVSKEYGHLLPGHRSQD 110
+E E R L +D D + S+ S E+E+E+ +E
Sbjct: 208 KEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEE----------- 256
Query: 111 HKVGDEGVSGEEVFAEHGGQARGHRGHGSEDTEDSAEHRHHLPSHRSHSHQDEDEDEVVS 170
+EG + EE E + GS E S + + S ++ EDE
Sbjct: 257 ----EEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEV------SEEEMSEDEERE 306
Query: 171 SEHHHHILRHGHRGHD-GEDDEGEEEEEEEEEEEEASTE 208
+E+H ++ D GE +E EEE E + A TE
Sbjct: 307 NENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTE 345
>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
5 [Homo sapiens]
Length = 748
Score = 100 bits (248), Expect = 6e-21
Identities = 95/378 (25%), Positives = 156/378 (41%), Gaps = 51/378 (13%)
Query: 249 DDDDDDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSHEEDDNDDD 308
+D +D ++DD ++I+ Q R + +DE R RHRSH +
Sbjct: 36 EDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEK-------RKEKRRHRSHSAEGGKHA 88
Query: 309 DVSTEYGHQAHRHQDHRKEEVEAVSGEHHHHVPDHRHQGHRDEEEDEDVSTERWHQGPQH 368
V + + H + +EE + E + H E D ER + +
Sbjct: 89 RVKEK--EREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERK 146
Query: 369 VHHGLVDEEEEEEEITVQFGHYVASHQPRGHKSDEEDFQDEYKTEVPHHHHHRVPREE-D 427
+ ++ E++E R +++E + E + EV HH R RE+
Sbjct: 147 MREQQKEQREQKE---------------RERRAEERRKEREARREVSAHH--RTMREDYS 189
Query: 428 EEVSAELGHQAPSHRQSHQDEETGHGQRGSIKEMSHHPPGHTVVKDRSHLRKDDSEEEKE 487
++V A ++P R + E G G++ P +++R L D ++ +
Sbjct: 190 DKVKASHWSRSPP-RPPRERFELGDGRK---------PVKEEKMEERDLL--SDLQDISD 237
Query: 488 KEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEEEDKEEEEEEE 547
E S E S+E G GS ++E+EE+EEE G + EE ++EEEEEEE
Sbjct: 238 SERKTSSAESS--SAESGS-----GSEEEEEEEEEEEEEGST-----SEESEEEEEEEEE 285
Query: 548 DEERREERAEVGAPLSPDHSEEEEEEEEGLEEDEPRFTIIPNPLDRREEAGGASSEEESG 607
+EE +E + S + EEE E+ E+E ++P R+ +EEE G
Sbjct: 286 EEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVG 345
Query: 608 EDTGPQDAQEYGNYQPGS 625
E T A G+Y P S
Sbjct: 346 EGTPQSSALTEGDYVPDS 363
Score = 47.8 bits (112), Expect = 4e-05
Identities = 26/100 (26%), Positives = 48/100 (48%), Gaps = 3/100 (3%)
Query: 188 EDDEGEEEEEEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEEDD 247
E G EEEEEEEEEEE E G + EE+E+ + + + E +
Sbjct: 251 ESGSGSEEEEEEEEEEE---EEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSE 307
Query: 248 DDDDDDDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDG 287
++ +D++ ++++ + + + R G E +E+V +G
Sbjct: 308 EEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEG 347
Score = 45.8 bits (107), Expect = 1e-04
Identities = 70/328 (21%), Positives = 104/328 (31%), Gaps = 59/328 (17%)
Query: 84 SHPDREKEDEDVSKEYGHLLPGHRSQDHKVGDEGVSGEEVFAEHGGQARGHRGHGSEDTE 143
S DR +ED+ ++ + P S+ KV + H R H G +
Sbjct: 38 SMEDRGEEDDSLAIKP----PQQMSRKEKVHHRKDEKRKEKRRH----RSHSAEGGKHAR 89
Query: 144 DSAEHRHHLPSHRSHSHQDEDEDEVVSSEHHHHILRHGHRGHD----------------- 186
+ R H R QD+ E + H R D
Sbjct: 90 VKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMRE 149
Query: 187 -----GEDDEGEEEEEEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSH--- 238
E E E EE +E EA E AH HR + + V H P
Sbjct: 150 QQKEQREQKERERRAEERRKEREARREV--SAH-HRTMREDYSDKVKASHWSRSPPRPPR 206
Query: 239 --------RHQGHEEDDDDDD--DDDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDGH 288
R EE ++ D D D D + + G G EE+E+ +
Sbjct: 207 ERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEE 266
Query: 289 HHRDPSHRHRSHEEDDNDDDDVSTEYGHQAHRHQDHRKEEV------EAVSGEHHHH--- 339
+ EE++ ++++ T G + + EEV E E+ +H
Sbjct: 267 EEEGSTSEESEEEEEEEEEEEEET--GSNSEEASEQSAEEVSEEEMSEDEERENENHLLV 324
Query: 340 VPDHRHQGHRDEEEDEDVSTERWHQGPQ 367
VP+ R RD E E+ E PQ
Sbjct: 325 VPESRFD--RDSGESEEAEEEVGEGTPQ 350
Score = 36.2 bits (82), Expect = 0.11
Identities = 38/159 (23%), Positives = 59/159 (37%), Gaps = 22/159 (13%)
Query: 51 EEASAELRHHLHSPRDHPDENKDVSTENGHHFWSHPDREKEDEDVSKEYGHLLPGHRSQD 110
+E E R L +D D + S+ S E+E+E+ +E
Sbjct: 219 KEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEE----------- 267
Query: 111 HKVGDEGVSGEEVFAEHGGQARGHRGHGSEDTEDSAEHRHHLPSHRSHSHQDEDEDEVVS 170
+EG + EE E + GS E S + + S ++ EDE
Sbjct: 268 ----EEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEV------SEEEMSEDEERE 317
Query: 171 SEHHHHILRHGHRGHD-GEDDEGEEEEEEEEEEEEASTE 208
+E+H ++ D GE +E EEE E + A TE
Sbjct: 318 NENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTE 356
>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
9 [Homo sapiens]
Length = 771
Score = 98.6 bits (244), Expect = 2e-20
Identities = 101/435 (23%), Positives = 163/435 (37%), Gaps = 69/435 (15%)
Query: 193 EEEEEEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEEDDDDDDD 252
E++ +E+EE+ + R S E+ ++ D H + R+ + +D +D
Sbjct: 19 EKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRD--HCMEITIRNSPYRREDSMEDR 76
Query: 253 DDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDGHHHR--DPSHRHRSHEEDDNDDDDV 310
++DD ++I+ Q R + +DE + H R + H + + D
Sbjct: 77 GEEDDS---LAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKA 133
Query: 311 STEYGHQAHRHQDHRKEEVEAVSGEHHHHVPDHRHQGHRDEEEDEDVSTERWHQGPQHVH 370
E+ Q R ++ EH D Q R E + + ++ Q Q
Sbjct: 134 RREWERQKRRE----------MAREHSRRERDRLEQLERKRERERKMREQQKEQREQKER 183
Query: 371 HGLVDEEEEEEEITVQFGHYVASHQPRGHKSDEEDFQDEYKTEVPHHHHHRVPREEDEEV 430
+E +E E + V++H H++ ED+ D+ K R PRE
Sbjct: 184 ERRAEERRKEREARRE----VSAH----HRTMREDYSDKVKASHWSRSPPRPPRER---- 231
Query: 431 SAELGHQAPSHRQSHQDEETGHGQRGSIKEMSHHPPGHTVVKDRSHLRKDDSEEEKEKEE 490
ELG ++ +E I + RK S E E
Sbjct: 232 -FELGDGRKPVKEEKMEERDLLSDLQDISDSE---------------RKTSSAESSSAES 275
Query: 491 DPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEEEDKEEEEEEEDEE 550
GS EE++E +EE+EEEG EE ++EEEEEEE+EE
Sbjct: 276 GSGSEEEEEE-----------------EEEEEEEG-------STSEESEEEEEEEEEEEE 311
Query: 551 RREERAEVGAPLSPDHSEEEEEEEEGLEEDEPRFTIIPNPLDRREEAGGASSEEESGEDT 610
+E + S + EEE E+ E+E ++P R+ +EEE GE T
Sbjct: 312 ETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGT 371
Query: 611 GPQDAQEYGNYQPGS 625
A G+Y P S
Sbjct: 372 PQSSALTEGDYVPDS 386
Score = 52.4 bits (124), Expect = 1e-06
Identities = 42/179 (23%), Positives = 83/179 (46%), Gaps = 15/179 (8%)
Query: 405 DFQDEYKTEVPHHHHHRVPREEDEEVSAELGHQAPSHRQSHQDEETGHGQRGSIKEMSHH 464
D +D +K + R +++E AE+ R + D+ +R S++E
Sbjct: 3 DEKDSWKVKTLDEILQEKKRRKEQEEKAEI------KRLKNSDDRDS--KRDSLEEGELR 54
Query: 465 PPGHTVVKDRSHLRKDDSEEEKEKEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEE 524
+ S R++DS E++ +E+D + + + S + + HH ++DE+ +E+
Sbjct: 55 DHCMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEK--VHH----RKDEKRKEK 108
Query: 525 GHGLSLNQEEEEEEDKEEEEEEEDEERREERAEVGAPLSPDHSEEEEEEEEGLEEDEPR 583
H + ++E E E ++ EE+D+ RRE + ++ +HS E + E LE R
Sbjct: 109 KHA-RVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRER 166
Score = 50.8 bits (120), Expect = 4e-06
Identities = 69/315 (21%), Positives = 108/315 (34%), Gaps = 44/315 (13%)
Query: 84 SHPDREKEDEDVS---------KEYGHLLPGHRSQDHKVGDEGVSGEEVFAEHGGQARGH 134
S DR +ED+ ++ KE H HR + + + +E EH + R
Sbjct: 72 SMEDRGEEDDSLAIKPPQQMSRKEKVH----HRKDEKRKEKKHARVKEKEREHERRKRHR 127
Query: 135 RGHGSEDTEDSAEHRHHLPSHRSHSHQDEDEDEVVSSEHHHHILRHGHRGHDGEDDEGEE 194
E + R + R HS ++ D E + + + E E E
Sbjct: 128 EEQDKARREWERQKRREMA--REHSRRERDRLEQLERKRERERKMREQQKEQREQKERER 185
Query: 195 EEEEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSH-----------RHQGH 243
EE +E EA E AH HR + + V H P R
Sbjct: 186 RAEERRKEREARREVS--AH-HRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVK 242
Query: 244 EEDDDDDD--DDDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSHE 301
EE ++ D D D D + + G G EE+E+ + + E
Sbjct: 243 EEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEE 302
Query: 302 EDDNDDDDVSTEYGHQAHRHQDHRKEEV------EAVSGEHHHH---VPDHRHQGHRDEE 352
E++ ++++ T G + + EEV E E+ +H VP+ R RD
Sbjct: 303 EEEEEEEEEET--GSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFD--RDSG 358
Query: 353 EDEDVSTERWHQGPQ 367
E E+ E PQ
Sbjct: 359 ESEEAEEEVGEGTPQ 373
Score = 36.2 bits (82), Expect = 0.11
Identities = 38/159 (23%), Positives = 59/159 (37%), Gaps = 22/159 (13%)
Query: 51 EEASAELRHHLHSPRDHPDENKDVSTENGHHFWSHPDREKEDEDVSKEYGHLLPGHRSQD 110
+E E R L +D D + S+ S E+E+E+ +E
Sbjct: 242 KEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEE----------- 290
Query: 111 HKVGDEGVSGEEVFAEHGGQARGHRGHGSEDTEDSAEHRHHLPSHRSHSHQDEDEDEVVS 170
+EG + EE E + GS E S + + S ++ EDE
Sbjct: 291 ----EEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEV------SEEEMSEDEERE 340
Query: 171 SEHHHHILRHGHRGHD-GEDDEGEEEEEEEEEEEEASTE 208
+E+H ++ D GE +E EEE E + A TE
Sbjct: 341 NENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTE 379
>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
8 [Homo sapiens]
Length = 780
Score = 97.8 bits (242), Expect = 3e-20
Identities = 105/437 (24%), Positives = 169/437 (38%), Gaps = 64/437 (14%)
Query: 193 EEEEEEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEEDDDDDDD 252
E++ +E+EE+ + R S E+ ++ D H + R+ + +D +D
Sbjct: 19 EKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRD--HCMEITIRNSPYRREDSMEDR 76
Query: 253 DDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDGHHHR--DPSHRHRSHEEDDNDDDDV 310
++D D ++I+ Q R + +DE + H R + H + + D
Sbjct: 77 GEED---DSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKA 133
Query: 311 STEYGHQAHRH--QDHRKEEVEAVSGEHHHHVPDHRHQGHRDEEEDEDVSTERWHQGPQH 368
E+ Q R ++H + E + D Q R E + + ++ Q Q
Sbjct: 134 RREWERQKRREMAREHSRRE---RGNDGVCLFRDRLEQLERKRERERKMREQQKEQREQK 190
Query: 369 VHHGLVDEEEEEEEITVQFGHYVASHQPRGHKSDEEDFQDEYKTEVPHHHHHRVPREEDE 428
+E +E E + V++H H++ ED+ D+ K R PRE
Sbjct: 191 ERERRAEERRKEREARRE----VSAH----HRTMREDYSDKVKASHWSRSPPRPPRER-- 240
Query: 429 EVSAELGHQAPSHRQSHQDEETGHGQRGSIKEMSHHPPGHTVVKDRSHLRKDDSEEEKEK 488
ELG ++ +E I + RK S E
Sbjct: 241 ---FELGDGRKPVKEEKMEERDLLSDLQDISDSE---------------RKTSSAESSSA 282
Query: 489 EEDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEEEDKEEEEEEED 548
E GS EE++E +EE+EEEG S ++E EEEE++EEEEEEE
Sbjct: 283 ESGSGSEEEEEE-----------------EEEEEEEG---STSEESEEEEEEEEEEEEET 322
Query: 549 EERREERAEVGAPLSPDHSEEEEEEEEGLEEDEPRFTIIPNPLDRREEAGGASSEEESGE 608
EE +E A + EEE E+ E+E ++P R+ +EEE GE
Sbjct: 323 GSNSEEASEQSA----EEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGE 378
Query: 609 DTGPQDAQEYGNYQPGS 625
T A G+Y P S
Sbjct: 379 GTPQSSALTEGDYVPDS 395
Score = 47.8 bits (112), Expect = 4e-05
Identities = 26/100 (26%), Positives = 48/100 (48%), Gaps = 3/100 (3%)
Query: 188 EDDEGEEEEEEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEEDD 247
E G EEEEEEEEEEE E G + EE+E+ + + + E +
Sbjct: 283 ESGSGSEEEEEEEEEEE---EEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSE 339
Query: 248 DDDDDDDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDG 287
++ +D++ ++++ + + + R G E +E+V +G
Sbjct: 340 EEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEG 379
Score = 47.0 bits (110), Expect = 6e-05
Identities = 38/166 (22%), Positives = 78/166 (46%), Gaps = 15/166 (9%)
Query: 405 DFQDEYKTEVPHHHHHRVPREEDEEVSAELGHQAPSHRQSHQDEETGHGQRGSIKEMSHH 464
D +D +K + R +++E AE+ R + D+ +R S++E
Sbjct: 3 DEKDSWKVKTLDEILQEKKRRKEQEEKAEI------KRLKNSDDRDS--KRDSLEEGELR 54
Query: 465 PPGHTVVKDRSHLRKDDSEEEKEKEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEE 524
+ S R++DS E++ +E+D + + + S + + HH ++DE+ +E+
Sbjct: 55 DHCMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEK--VHH----RKDEKRKEK 108
Query: 525 GHGLSLNQEEEEEEDKEEEEEEEDEERREERAEVGAPLSPDHSEEE 570
H + ++E E E ++ EE+D+ RRE + ++ +HS E
Sbjct: 109 KHA-RVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRE 153
Score = 45.8 bits (107), Expect = 1e-04
Identities = 66/321 (20%), Positives = 110/321 (34%), Gaps = 47/321 (14%)
Query: 84 SHPDREKEDEDVS---------KEYGHLLPGHRSQDHKVGDEGVSGEEVFAEHGGQARGH 134
S DR +ED+ ++ KE H HR + + + +E EH + R
Sbjct: 72 SMEDRGEEDDSLAIKPPQQMSRKEKVH----HRKDEKRKEKKHARVKEKEREHERRKRHR 127
Query: 135 RGHGSEDTEDSAEHRHHLPSHRSHSHQDEDEDEV-VSSEHHHHILRHGHRGHDGEDDEGE 193
E + R + R HS ++ D V + + + R R + + E
Sbjct: 128 EEQDKARREWERQKRREMA--REHSRRERGNDGVCLFRDRLEQLERKRERERKMREQQKE 185
Query: 194 EEEEEEEEEEEASTEYGHQAHR-----HRGHGSEEDEDVSDGHHHHGPSH---------- 238
+ E++E E +A R HR + + V H P
Sbjct: 186 QREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGD 245
Query: 239 -RHQGHEEDDDDDD--DDDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDGHHHRDPSH 295
R EE ++ D D D D + + G G EE+E+ + +
Sbjct: 246 GRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTS 305
Query: 296 RHRSHEEDDNDDDDVSTEYGHQAHRHQDHRKEEV------EAVSGEHHHH---VPDHRHQ 346
EE++ ++++ T G + + EEV E E+ +H VP+ R
Sbjct: 306 EESEEEEEEEEEEEEET--GSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFD 363
Query: 347 GHRDEEEDEDVSTERWHQGPQ 367
RD E E+ E PQ
Sbjct: 364 --RDSGESEEAEEEVGEGTPQ 382
Score = 36.2 bits (82), Expect = 0.11
Identities = 38/159 (23%), Positives = 59/159 (37%), Gaps = 22/159 (13%)
Query: 51 EEASAELRHHLHSPRDHPDENKDVSTENGHHFWSHPDREKEDEDVSKEYGHLLPGHRSQD 110
+E E R L +D D + S+ S E+E+E+ +E
Sbjct: 251 KEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEE----------- 299
Query: 111 HKVGDEGVSGEEVFAEHGGQARGHRGHGSEDTEDSAEHRHHLPSHRSHSHQDEDEDEVVS 170
+EG + EE E + GS E S + + S ++ EDE
Sbjct: 300 ----EEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEV------SEEEMSEDEERE 349
Query: 171 SEHHHHILRHGHRGHD-GEDDEGEEEEEEEEEEEEASTE 208
+E+H ++ D GE +E EEE E + A TE
Sbjct: 350 NENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTE 388
>gi|24415404 MDN1, midasin homolog [Homo sapiens]
Length = 5596
Score = 97.8 bits (242), Expect = 3e-20
Identities = 114/465 (24%), Positives = 182/465 (39%), Gaps = 91/465 (19%)
Query: 195 EEEEEEEEEEASTEYGHQAHRHRGHGSEEDE---DVSD--GHHHHGPSHRHQGHEEDDDD 249
+E E+ E +TE+ H + G G E E DVSD G+ +G E+D +D
Sbjct: 4658 KEFMEDSAGEGATEF----HDYEGGGIGEGEGMKDVSDQIGNEEQVEDTFQKGQEKDKED 4713
Query: 250 DDDDDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSHEEDDNDDDD 309
D D +D+ IE ED H + + E+ D++ D
Sbjct: 4714 PDSKSDIKGEDNA---------------IEMSEDFDGKMHDGELEEQEEDDEKSDSEGGD 4758
Query: 310 VSTEYGHQAHRHQDHRKEEVEAVSGEHHHHVPDHRHQGHRDEEEDE---DVSTERWHQGP 366
+ G D EE + + D R G DEEEDE D TE G
Sbjct: 4759 LDKHMG-------DLNGEEADKL---------DERLWGDDDEEEDEEEEDNKTEETGPGM 4802
Query: 367 QHVHHGLV------------------DEEEEEEEITVQFGHYVASHQPRGHKSDEEDFQD 408
LV D++EE+EE G + DE D+ D
Sbjct: 4803 DEEDSELVAKDDNLDSGNSNKDKSQQDKKEEKEEAEADDGGQ--GEDKINEQIDERDY-D 4859
Query: 409 EYKTEVPHHHHHRVPREEDEEVSAELGHQAPSHRQSHQDEETGHGQRGSIKEMSHHPP-- 466
E + + H + +VP E ++ +L + + +D + G+ + E+ P
Sbjct: 4860 ENEVDPYHGNQEKVPEPEALDLPDDLNLDSED-KNGGEDTDNEEGEEENPLEIKEKPEEA 4918
Query: 467 GHTVVKDRSHLRKDDSEEEKEKEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGH 526
GH ++R D +E + +E + G E+D +GE+ G+ DQ+
Sbjct: 4919 GHEA-EERGETETDQNESQSPQEPEEGPSEDD---KAEGEEEMDTGADDQD--------- 4965
Query: 527 GLSLNQEEEEEEDKEEEEEEEDEERREERAEVGAPLSPDHSEEEEEEEEGLEEDEPRFTI 586
G + EE E++++ EE+D+E EE E G P +EEEE E + +E
Sbjct: 4966 GDAAQHPEEHSEEQQQSVEEKDKEADEEGGENG-PADQGFQPQEEEEREDSDTEEQ---- 5020
Query: 587 IPNPLDRREEAGGASSEEESGEDT------GPQDAQEYGNYQPGS 625
+P L+R+E A + E+ ++T G +E G + GS
Sbjct: 5021 VPEALERKEHASCGQTGVENMQNTQAMELAGAAPEKEQGKEEHGS 5065
Score = 90.5 bits (223), Expect = 5e-18
Identities = 114/521 (21%), Positives = 203/521 (38%), Gaps = 68/521 (13%)
Query: 69 DENKDVSTENGHHFWSHPDREKEDEDVSKEYGHLLPGHRSQDHKVGDEGVSGEEVFAEHG 128
DE +D E+ + P ++ED ++ + +L G+ ++D D+ EE A+ G
Sbjct: 4783 DEEEDEEEEDNKTEETGPGMDEEDSELVAKDDNLDSGNSNKDKSQQDKKEEKEEAEADDG 4842
Query: 129 GQARGHRGHGSEDTEDSAEHRHHLPSHRSHSHQDED---EDEVVSSEHHHHILRHGHRGH 185
GQ G + + + R + + H +++ E E + ++ G
Sbjct: 4843 GQ-------GEDKINEQIDERDYDENEVDPYHGNQEKVPEPEALDLPDDLNLDSEDKNG- 4894
Query: 186 DGEDDEGEEEEEEEEEE-EEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHE 244
GED + EE EEE E +E E GH+A E E +D + P +G
Sbjct: 4895 -GEDTDNEEGEEENPLEIKEKPEEAGHEA-------EERGETETDQNESQSPQEPEEGPS 4946
Query: 245 EDDDDDDDDDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSHEEDD 304
EDD + +++ D DD +D D + H + +S EE D
Sbjct: 4947 EDDKAEGEEEMDTGADD------------------QDGDAAQ-HPEEHSEEQQQSVEEKD 4987
Query: 305 NDDDDVSTEYGHQAHRHQDHRKEEVEAVSGEHHHHVPDHRHQGHRDEEEDEDVSTERWHQ 364
+ D+ E G Q +EE E + VP+ + ++ E
Sbjct: 4988 KEADEEGGENGPADQGFQPQEEEERE--DSDTEEQVPEALER--KEHASCGQTGVENMQN 5043
Query: 365 GPQHVHHGLVDEEEEEEEITVQFGHYVA-SHQPRGHKSD-EEDFQDEYKTEVPHHHHHRV 422
G E+E+ +E + G A ++Q GH+S+ + T R
Sbjct: 5044 TQAMELAGAAPEKEQGKE---EHGSGAADANQAEGHESNFIAQLASQKHTRKNTQSFKRK 5100
Query: 423 PREEDEEVSAELGHQAPSHRQSHQDEETGHGQRGSIKEMSHHPPGHTVVKDRSHLRKDDS 482
P + D E S H H++ + H ++G ++ ++ + D+
Sbjct: 5101 PGQADNERSMG-DHNERVHKRLRTVDTDSHAEQGPAQQ------------PQAQVEDADA 5147
Query: 483 EEEKEKEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEEEDKEE 542
E ++ D + D +S++ ++ +DQE+EE E+ +L EE+EE K
Sbjct: 5148 FEHIKQGSDAYDAQTYDVASKEQQQSAKDSGKDQEEEEIED-----TLMDTEEQEEFKAA 5202
Query: 543 EEEEEDEERREERAEVGAPLSPDHSEEEEEEEEGLEEDEPR 583
+ E+ E E ++ APL D E E + + E+ +PR
Sbjct: 5203 DVEQLKPE--EIKSGTTAPLGFDEMEVEIQTVKTEEDQDPR 5241
Score = 85.9 bits (211), Expect = 1e-16
Identities = 117/618 (18%), Positives = 230/618 (37%), Gaps = 90/618 (14%)
Query: 32 GDGLGFRNRNNSTGVAGLSEEASAELRHHLHSPRDHPDENKDVSTENGH----------- 80
G+G G ++ ++ G E+ + ++ PD D+ E+
Sbjct: 4681 GEGEGMKDVSDQIGN---EEQVEDTFQKGQEKDKEDPDSKSDIKGEDNAIEMSEDFDGKM 4737
Query: 81 HFWSHPDREKEDEDVSKEYGHLLPGHRSQDHKVGDEGVSGEEVFAEHGGQARGHRGHGSE 140
H ++E++DE E G L D +GD ++GEE R G +
Sbjct: 4738 HDGELEEQEEDDEKSDSEGGDL-------DKHMGD--LNGEEA------DKLDERLWGDD 4782
Query: 141 DTEDSAEHRHHLPSHRSHSHQDEDEDEVVSSEHHHHILRHGHRGHDGEDDEGEEEEEEEE 200
D E+ E + + + DE++ E+V+ + + G ++ + +++++E
Sbjct: 4783 DEEEDEEEEDN-KTEETGPGMDEEDSELVAKDDNLD---------SGNSNKDKSQQDKKE 4832
Query: 201 EEEEASTEYGHQAH-RHRGHGSEEDEDVSDGHHHHGPSHRHQGHE------------EDD 247
E+EEA + G Q + E D D ++ +HG + E ED
Sbjct: 4833 EKEEAEADDGGQGEDKINEQIDERDYDENEVDPYHGNQEKVPEPEALDLPDDLNLDSEDK 4892
Query: 248 DDDDDDDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSHEEDDNDD 307
+ +D D+++ +++ +E + + E E +D + + P EDD +
Sbjct: 4893 NGGEDTDNEEGEEENPLEIKEKPEEAGHEAEERGETETDQNESQSPQEPEEGPSEDDKAE 4952
Query: 308 DDVSTEYGHQAHRHQDHRKEEVEAVSGEHHHHVPDHRHQGHRD-EEEDEDVSTERWHQGP 366
+ + G + G+ H +H + + EE+D++ E GP
Sbjct: 4953 GEEEMDTG-------------ADDQDGDAAQHPEEHSEEQQQSVEEKDKEADEEGGENGP 4999
Query: 367 QHVHHGLVDEEEEEEEITVQFGHYVASHQPRGHKS----DEEDFQDEYKTEVPHHHHHRV 422
G +EEEE E + + + + H S E+ Q+ E+ +
Sbjct: 5000 --ADQGFQPQEEEEREDSDTEEQVPEALERKEHASCGQTGVENMQNTQAMELAGAAPEKE 5057
Query: 423 PREEDEEVSAELGHQAPSH--------------RQSHQDEETGHGQRGSIKEMSHHPPGH 468
+E+ A +QA H R++ Q + GQ + + M H +
Sbjct: 5058 QGKEEHGSGAADANQAEGHESNFIAQLASQKHTRKNTQSFKRKPGQADNERSMGDH---N 5114
Query: 469 TVVKDRSHLRKDDSEEEKEKEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGL 528
V R DS E+ + P + ED ++ E ++G+ D +E+
Sbjct: 5115 ERVHKRLRTVDTDSHAEQGPAQQPQAQVEDADAFEHIKQGSDAYDAQTYDVASKEQQQSA 5174
Query: 529 SLNQEEEEEEDKEEEEEEEDEERREERAEVGAPLSPDHSEEEEEEEEGLEEDEPRFTIIP 588
+ +++EE++ E+ + EE+ E +A L P+ + G +E E +
Sbjct: 5175 K-DSGKDQEEEEIEDTLMDTEEQEEFKAADVEQLKPEEIKSGTTAPLGFDEMEVEIQTVK 5233
Query: 589 NPLDRREEAGGASSEEES 606
D+ A E E+
Sbjct: 5234 TEEDQDPRTDKAHKETEN 5251
>gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]
Length = 1564
Score = 95.1 bits (235), Expect = 2e-19
Identities = 103/481 (21%), Positives = 163/481 (33%), Gaps = 51/481 (10%)
Query: 145 SAEHRHHLPSHRSHSHQDEDEDEVVSSEHHHHILRHGHRGHDGEDDEGEEEEEEEEEEEE 204
S + + P HRS + D +S+ H RH R ED G+ + E++ EE
Sbjct: 381 SPQRKQSPPRHRSPMREKGRHDHERTSQSHDR--RHERR----EDTRGKRDREKDSREER 434
Query: 205 ASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEEDDDDDDDDDDDDDDDDVSI 264
EY R H +D + DG E D D D + D
Sbjct: 435 ---EYEQDQSSSRDH--RDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRD----- 484
Query: 265 EYRHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSHEEDDNDDDDVSTEYGHQAHRHQDH 324
+ + + D H +RD R +ED ++ S YG R +
Sbjct: 485 ---YSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEE--SRSYGRNHLREESS 539
Query: 325 RKEEVEAVSGEHHHHVPDHRHQGHRDEEEDEDVSTERWHQGPQHVHHGLVDEEEEEEEIT 384
R E E + + R R + R +G Q H + E
Sbjct: 540 RTEIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWE-- 597
Query: 385 VQFGHYVASHQPRGHKSDEEDFQDEYKTEVPHHHH----HRVPREEDEEVSAELGHQAPS 440
S P + E D +D+ + H R RE D+ S+ + HQ
Sbjct: 598 ------TRSSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQG-- 649
Query: 441 HRQSHQDEETGHGQRGSIKEMSHHPPGHTVVKDRSHLRKDDSEEEKEKEEDPGSHEEDDE 500
++ + E + + + +DR R + E E+E+E D +E +
Sbjct: 650 --RNDELERDERREERRVDRVDDRRDERARERDRERERDRERERERERERDREREKEREL 707
Query: 501 SSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEEEDKEEEEEEEDEERREERAEVGA 560
E+ + ++++ E D + H +E E + +KE E E E+ ER ER
Sbjct: 708 ERERAREREREREKERDRERDRDRDHDRERERERERDREKEREREREERERERERER--- 764
Query: 561 PLSPDHSEEEEEEEEGLEEDEPRFTIIPNPLDRREEAGG----ASSEEESGEDTGPQDAQ 616
E E E E E D+ R D ++ G EE ED P+D
Sbjct: 765 ---ERERERERERERARERDKER----ERQRDWEDKDKGRDDRREKREEIREDRNPRDGH 817
Query: 617 E 617
+
Sbjct: 818 D 818
Score = 62.4 bits (150), Expect = 1e-09
Identities = 89/462 (19%), Positives = 161/462 (34%), Gaps = 40/462 (8%)
Query: 135 RGHGSEDTEDSAEHRHHLPSHRSHSHQDEDEDEVVSSEHHHHILRHGHRGHDGEDDEGEE 194
R HG D D+ E S H ++ DE+ E R R D DD +E
Sbjct: 624 RRHGERDRRDNRERDQRPSSPIRHQGRN---DELERDE------RREERRVDRVDDRRDE 674
Query: 195 EEEEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEEDDDDDDDDD 254
E + E E E + R R E++ ++ R + E++ D + D D
Sbjct: 675 RARERDRERERDRERERERERERDREREKERELE----RERAREREREREKERDRERDRD 730
Query: 255 DDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSHEEDDNDDDDVSTEY 314
D D + E + + EE E + R+ + D +
Sbjct: 731 RDHDRER-ERERERDREKEREREREERERERERERERERERERERERARERDKERERQRD 789
Query: 315 GHQAHRHQDHRKEEVEAVSGEHHHHVPDHRHQGHRDEEEDEDVSTERWHQGPQHVHHGLV 374
+ +D R+E+ E + + + P H + ++ + + Q P+
Sbjct: 790 WEDKDKGRDDRREKREEIREDRN---PRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSP 846
Query: 375 DEEEEEEEITVQFGHYVASHQPRGHKSDE-------EDFQDEYKTEVPHHHHHRVPREED 427
D + H + S R +S ED Q +K E R +
Sbjct: 847 DSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYE 906
Query: 428 EEVSAELGHQAPSHRQSHQDEETGHGQRGSIKEMSHHPPGHTVVKDRSHLRKDDSEEEKE 487
E+ E R+ + E+ + I + HH DR+H D+++++ +
Sbjct: 907 EQELKEKVSSVDKQREQTEILESSRMRAQDI--IGHHQSEDRETSDRAH---DENKKKAK 961
Query: 488 KEEDP-GSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEEEDKEEEEEE 546
++ P +EDD E+G T ED + G E++ + + + +
Sbjct: 962 IQKKPIKKKKEDDVGIERGNIET-----TSEDGQVFSPKKGQKKKSIEKKRKKSKGDSDI 1016
Query: 547 EDEERREERAEVGAPLSPDHSEEEEEEE-----EGLEEDEPR 583
DEE ++ + P +P + +EE E G+ ED +
Sbjct: 1017 SDEEAAQQSKKKRGPRTPPITTKEELVEMCNGKNGILEDSQK 1058
Score = 50.1 bits (118), Expect = 7e-06
Identities = 84/467 (17%), Positives = 168/467 (35%), Gaps = 62/467 (13%)
Query: 194 EEEEEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEEDDDDDDDD 253
+ E ++ EE+S+ ++ R R H +ED ++ R EE++ + + +
Sbjct: 97 DTEPQKRNTEESSSPVRKESSRGR-HREKEDIKIT--------KERTPESEEENVEWETN 147
Query: 254 DDDDDDDDVSIEYRHQAH-------------RHQGHGIEEDEDV---------------- 284
DD D+ D++ +Y H+ + + +E+ E++
Sbjct: 148 RDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENMEKREEIIIKKEVSPEVVRSKLS 207
Query: 285 -------SDGHHHRDPSHRHRSHEEDDNDDDDVSTEYGHQAHRHQDHRKEEVEAVSGEHH 337
S R S + S + D VS+ Q + ++ ++ +
Sbjct: 208 PSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQSKKKGPRTPSPP 267
Query: 338 HHVPDHRHQG--HRDEEEDEDVSTERWHQGPQHVH-HGLVDEEEEEEEITVQFGHYVASH 394
+P+ G ++++ + +D E+ G E+ ++ T G + +
Sbjct: 268 PPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRGRDFERQREKRDKPRSTSPAGQHHSPI 327
Query: 395 QPRGHKSDEEDFQDEYKTEVPHHHHHRVPREE-DEEVSAELGHQA---PSHR-QSHQDEE 449
R H S + + P R P ++ L A PSH S Q ++
Sbjct: 328 SSRHHSSSSQS-GSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLSSPQRKQ 386
Query: 450 TGHGQRGSIKEMSHHPPGHTVVK-DRSHLRKDDSEEEKEKEEDPGSHEEDDESSEQGEKG 508
+ R ++E H T DR H R++D+ ++++E+D S EE + +Q
Sbjct: 387 SPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKD--SREEREYEQDQSSSR 444
Query: 509 THHGSRDQEDEEDEEEGHGLSLNQEEEEEEDKEEEEEEED-----EERREERAEVGAPLS 563
H R+ D D + +E + D + E D +E R+ R +
Sbjct: 445 DHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDA 504
Query: 564 PDHSEEEEEEEEGLEEDEPRFTIIPNPLDRREEAGGASSEEESGEDT 610
D+ + E + E+ P + REE+ ES ++
Sbjct: 505 HDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNES 551
Score = 39.3 bits (90), Expect = 0.013
Identities = 46/214 (21%), Positives = 85/214 (39%), Gaps = 42/214 (19%)
Query: 411 KTEVPH----HHHHRVPREEDEEVSAELGH------------QAPSHRQSHQDEETGHGQ 454
K E PH HR P D++ S+ LG ++PS+ +H+ + G+
Sbjct: 1167 KVETPHVTIEDAQHRKPM--DQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGDDQSGR 1224
Query: 455 RGSIKEMSHHPPGHTVVKDRSHLRKDDSEEEKEKEEDPGSHEEDDESSEQGEKGTH-HGS 513
+ + H+ +DR + + E++ D E S+ + + H S
Sbjct: 1225 KRVL---------HSGSRDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSS 1275
Query: 514 RDQEDEEDEE--EGHGLSLNQEEEEEEDKEEEEEEEDEERREER-------AEVGAPLSP 564
R E D + G +++ +E D+ E + E + ERR+ R A+ P +
Sbjct: 1276 RRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQREWDRDADKDWPRNR 1335
Query: 565 DHS-----EEEEEEEEGLEEDEPRFTIIPNPLDR 593
D E E E ++ + D R +I + ++R
Sbjct: 1336 DRDRLRERERERERDKRRDLDRERERLISDSVER 1369
Score = 38.9 bits (89), Expect = 0.016
Identities = 46/237 (19%), Positives = 81/237 (34%), Gaps = 33/237 (13%)
Query: 403 EEDFQDEYKTEVPHHHHHRVPREEDEEVSAELGHQAPSHRQSHQDEETGHGQ-----RGS 457
+ + +D+ ++ P HH S++ G H S + + T
Sbjct: 307 QREKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPP 366
Query: 458 IKEMSHHPPGHTVVKDRSHLRKDDSEEEKEKEEDPGSHEEDDESSEQGEKGTHHGSRDQE 517
++ + P H++ S RK + + G H D E + Q H D
Sbjct: 367 LRRSASPYPSHSL---SSPQRKQSPPRHRSPMREKGRH--DHERTSQSHDRRHERREDTR 421
Query: 518 DEEDEEEGHGLSLNQEEEEEEDKEEEEEEEDEERREERAEVGAPLSPDHSE--------- 568
+ D E+ S + E E++ + +D E R+ R A + D E
Sbjct: 422 GKRDREKD---SREEREYEQDQSSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRD 478
Query: 569 EEEEEEEGLEEDEPRFTIIPNPLDRREEAGGASSEEESG------EDTGPQDAQEYG 619
E + + E R +P D R + G EDT P++++ YG
Sbjct: 479 SREMRDYSRDTKESR-----DPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYG 530
Score = 32.7 bits (73), Expect = 1.2
Identities = 26/99 (26%), Positives = 48/99 (48%), Gaps = 5/99 (5%)
Query: 459 KEMSHHPPGHTVVKDRSHLRKDDSE-EEKEKEEDPGSHEEDDESSEQGEKGTHHGSRDQE 517
+++ P + S +RK+ S +EKE+ + E ES E+ + +RD
Sbjct: 94 QDVDTEPQKRNTEESSSPVRKESSRGRHREKEDIKITKERTPESEEENVEW--ETNRDDS 151
Query: 518 DEED--EEEGHGLSLNQEEEEEEDKEEEEEEEDEERREE 554
D D + H LSL + ++ + + + E+E+ E+REE
Sbjct: 152 DNGDINYDYVHELSLEMKRQKIQRELMKLEQENMEKREE 190
Score = 32.3 bits (72), Expect = 1.5
Identities = 39/183 (21%), Positives = 73/183 (39%), Gaps = 16/183 (8%)
Query: 440 SHRQSHQDEETGHGQRGSI--KEMSHHPPGHTVVKDRSHLRKDDSEEEKEKEED---PGS 494
S R S + + H + GS ++ + ++R R+D + E +++ D P +
Sbjct: 1275 SRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQREWDRDADKDWPRN 1334
Query: 495 HEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEEEDKEEEEEEEDEERREE 554
+ D + E+ RD+ + D E +S + E + + D++ E E +
Sbjct: 1335 RDRDRLRERERER-----ERDKRRDLDRERERLISDSVERDRDRDRDRTFESSQIE-SVK 1388
Query: 555 RAEVGAPLSPDHSEE-EEEEEEGLEEDEPRFTIIPNPLDRREEAGGASSEE--ESGEDTG 611
R E A L +H + E + L D+ R + EE + E E+G+D
Sbjct: 1389 RCE--AKLEGEHERDLESTSRDSLALDKERMDKDLGSVQGFEETNKSERTESLEAGDDES 1446
Query: 612 PQD 614
D
Sbjct: 1447 KLD 1449
>gi|60097902 filaggrin [Homo sapiens]
Length = 4061
Score = 94.7 bits (234), Expect = 3e-19
Identities = 143/660 (21%), Positives = 206/660 (31%), Gaps = 107/660 (16%)
Query: 48 GLSEEASAELRHHLHSPRDHPDENKDVSTENGHHFW-------SHPDREKEDEDVSKEYG 100
G + SA+ H PR + ++GH W S + E+ D G
Sbjct: 1034 GSRHQQSADSSRHSGIPRR---QASSAVRDSGH--WGSSGSQASDSEGHSEESDTQSVSG 1088
Query: 101 HLLPGHRSQDHKV-------GDEGVSGEEVFA----EHGGQARGH--------RGHGSED 141
H G Q H+ G G SG ++ E A G +G E
Sbjct: 1089 HGQDGPHQQSHQESARDWSGGRSGRSGSFIYQVSTHEQSESAHGRTRTSTGRRQGSHHEQ 1148
Query: 142 TEDSAEH----------RHHLPSHRSH---SHQDEDEDEVV-SSEHHHHILRHGHRGHDG 187
DS+ H R H S R SH ++ D S HH H G
Sbjct: 1149 ARDSSRHSASQEGQDTIRAHPGSRRGGRQGSHHEQSVDRSGHSGSHHSHTTSQGRSDASH 1208
Query: 188 EDDEGEEEEEEEEEEEEASTEYGHQAHRHRGHGSEEDED----VSDGHHHHGPSHRHQGH 243
+ +++++ H RH S D V + RHQG
Sbjct: 1209 GQSGSRSASRQTRKDKQSGDGSRHSGSRHHEAASWADSSRHSQVGQEQSSGSRTSRHQGS 1268
Query: 244 EEDDDDDDDDDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVS--DGHHHRD-PSHRHRSH 300
D D + DD + R+ H G E+ D S G H D SH H +
Sbjct: 1269 SVSQDSDSERHSDDSERLSGSASRN----HHGSSREQSRDGSRHPGFHQEDRASHGHSAD 1324
Query: 301 EEDDNDDDDV-STEYGHQAHRHQDHRKEEVEAVSGEHHHHVPDHRHQG--HRDEEEDEDV 357
+ S+ +G H+ R E H RH G HR
Sbjct: 1325 SSRQSGTHHTESSSHGQAVSSHEQARSSPGERHGSRHQQSADSSRHSGIGHRQASSAVRD 1384
Query: 358 STERWHQGPQHVHHGLVDEEEEEEEITV--QFGHYVASHQP--RGHKSDEEDFQDEYKTE 413
S R G Q + E+ + + ++ Q G + SH+ RG + + +
Sbjct: 1385 SGHRGSSGSQVTNSEGHSEDSDTQSVSAHGQAGPHQQSHKESARGQSGESSGRSRSFLYQ 1444
Query: 414 VPHH------HHHRVPREEDEEVSA-ELGHQAPSHRQSHQDEET--GH------GQRGSI 458
V H H P + S E + H S ++T GH G++GS
Sbjct: 1445 VSSHEQSESTHGQTAPSTGGRQGSRHEQARNSSRHSASQDGQDTIRGHPGSSRGGRQGSY 1504
Query: 459 KEMSHHPPGHTVVKDRSHLRKDDSEEEKEKEEDPGSHEEDDESSEQGEKGTHH-GSRDQE 517
E S GH+ SH + + P S + EQ G+ H GSR E
Sbjct: 1505 HEQSVDRSGHSGYH-HSHTTPQGRSDASHGQSGPRSASRQTRNEEQSGDGSRHSGSRHHE 1563
Query: 518 DE------------EDEEEGHGLSLNQEEEEEEDKEEEEEEEDEERREERAEVGAPLSPD 565
+ E G S Q +D++ E ED ERR E A
Sbjct: 1564 PSTRAGSSRHSQVGQGESAGSKTSRRQGSSVSQDRDSEGHSEDSERRSESAS-----RNH 1618
Query: 566 HSEEEEEEEEGLEEDEPRFTIIPNPLDRREEAGGASSEEESGEDTGPQDAQEYGNYQPGS 625
+ E+ G NP +E+ ES +G + A+ Q S
Sbjct: 1619 YGSAREQSRHGSR----------NPRSHQEDRASHGHSAESSRQSGTRHAETSSGGQAAS 1668
Score = 91.7 bits (226), Expect = 2e-18
Identities = 122/599 (20%), Positives = 201/599 (33%), Gaps = 73/599 (12%)
Query: 50 SEEASAELRHHLHSPR-----DHPDENKDVSTENGHHFWSHPDREKEDEDVSKEYGHLLP 104
S+E +R H S R H +++ D S +G H + + D H
Sbjct: 1158 SQEGQDTIRAHPGSRRGGRQGSHHEQSVDRSGHSGSHHSHTTSQGRSDAS------HGQS 1211
Query: 105 GHRSQDHKVGDEGVSGEEVFAEHGGQARGHRGHGSEDTEDSAEH----RHHLPSHRSHSH 160
G RS + + SG+ G + G R H + DS+ H + R+ H
Sbjct: 1212 GSRSASRQTRKDKQSGD------GSRHSGSRHHEAASWADSSRHSQVGQEQSSGSRTSRH 1265
Query: 161 Q----DEDEDEVVSSEHHHHILRHGHRGHDGEDDEGEEEEEEEEEEEEASTEYGHQAHRH 216
Q +D D S+ + R H G E+ + S G
Sbjct: 1266 QGSSVSQDSDSERHSDDSERLSGSASRNHHGSS---------REQSRDGSRHPGFHQEDR 1316
Query: 217 RGHGSEEDEDVSDGHHHHGPSHRHQGHEEDDDDDDDDDDDDDDDDVSIEYRHQ----AHR 272
HG D G HH S Q + + RHQ + R
Sbjct: 1317 ASHGHSADSSRQSGTHHTESSSHGQAVSSHEQARSSPGERHGS-------RHQQSADSSR 1369
Query: 273 HQGHGIEEDEDVSDGHHHRDPSHRHRSHEEDDNDDDDVSTEYGH-QAHRHQDHRKEEVEA 331
H G G + HR S ++ E ++D D + H QA HQ KE
Sbjct: 1370 HSGIGHRQASSAVRDSGHRGSSGSQVTNSEGHSEDSDTQSVSAHGQAGPHQQSHKESARG 1429
Query: 332 VSGEHHHHVPDHRHQGHRDEEED----EDVSTERWHQGPQH--VHHGLVDEEEEEEEITV 385
SGE +Q E+ + + + QG +H + ++ + T+
Sbjct: 1430 QSGESSGRSRSFLYQVSSHEQSESTHGQTAPSTGGRQGSRHEQARNSSRHSASQDGQDTI 1489
Query: 386 QFGHYVASHQPRGHKSDEEDFQDEYKTEVPHHHHHRVPREEDEEVSAELGHQAPSHRQSH 445
+ GH +S R E+ + +HH H P+ + + G ++ S RQ+
Sbjct: 1490 R-GHPGSSRGGRQGSYHEQSV--DRSGHSGYHHSHTTPQGRSDASHGQSGPRSAS-RQTR 1545
Query: 446 QDEETGHGQRGSIKEMSHHPPGHTVVKDR-SHLRKDDSEEEKEKEEDPGSHEEDDES--- 501
+E++G G R S HH P R S + + +S K S +D +S
Sbjct: 1546 NEEQSGDGSRHSGSR--HHEPSTRAGSSRHSQVGQGESAGSKTSRRQGSSVSQDRDSEGH 1603
Query: 502 SEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEEEDKEEEEEEEDEERREERAEVGAP 561
SE E+ + SR+ E+ HG + +E+ E + AE +
Sbjct: 1604 SEDSERRSESASRNHYGSAREQSRHGSRNPRSHQEDRASHGHSAESSRQSGTRHAETSSG 1663
Query: 562 LSPDHSEEEEEEEEGLEEDEPRFTIIPNPLDRREEAGGASSEEESGEDTGPQDAQEYGN 620
S+E+ G R +++ +S++ +G + GN
Sbjct: 1664 GQAASSQEQARSSPGERHGS-----------RHQQSADSSTDSGTGRRQDSSVVGDSGN 1711
Score = 91.3 bits (225), Expect = 3e-18
Identities = 127/588 (21%), Positives = 180/588 (30%), Gaps = 75/588 (12%)
Query: 33 DGLGFRNRNNSTGVAGLSEEASAELRHHLHSPRDHPDENKDVSTENGHHFWSHPDREKED 92
D G +++ V+G + A + H S RD S + +H E
Sbjct: 3342 DSEGHSEESDTQSVSGHGQ-AGPHQQSHQESARDRSGGRSGRSGSFLYQVSTHEQSESAH 3400
Query: 93 EDVSKEYGHLLPGHRSQDHKVGDEGVS--GEEVFAEHGGQARGHRGHGSEDTEDSAEHRH 150
G H Q S G++ H G +R RG E S +
Sbjct: 3401 GRTRTSTGRRQGSHHEQARDSSRHSASQEGQDTIRGHPGSSR--RGRQGSHYEQSVDRSG 3458
Query: 151 HLPSHRSHSHQDEDEDEVVSSEHHHHILRHGHRGHDGEDDEGEEEEEEEEEEEEASTEYG 210
H SH SH+ D + R R ++ G+ EAST+
Sbjct: 3459 HSGSHHSHTTSQGRSD----ASRGQSGSRSASRQTRNDEQSGDGSRHSWSHHHEASTQAD 3514
Query: 211 HQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEEDDDDDDDDDDDDDDDDVSIEYRHQA 270
H G G S R+QG D D +D + + A
Sbjct: 3515 SSRHSQSGQGQSAGPRTS----------RNQGSSVSQDSDSQGHSEDSE-----RWSGSA 3559
Query: 271 HR-HQGHGIEEDEDVS---DGHHHRDPSHRHRSHEEDDNDDDDVSTEYGHQAHRHQDHRK 326
R H+G E+ D S HH H H + + G QA + +
Sbjct: 3560 SRNHRGSAQEQSRDGSRHPTSHHEDRAGHGHSAESSRQSGTHHAENSSGGQAASSHEQAR 3619
Query: 327 EEVEAVSGEHHHHVPD---HRHQGHRDEEEDEDVSTERWHQGPQHVHHGLVDEEEEEEEI 383
G HH D H GH S R G Q E+ + + +
Sbjct: 3620 SSAGERHGSHHQQSADSSRHSGIGHGQASSAVRDSGHRGSSGSQASDSEGHSEDSDTQSV 3679
Query: 384 TV--QFGHYVASHQP--RGHKSDEEDFQDEYKTEVPHH------HHHRVPREEDEEVSA- 432
+ Q G + SHQ RG + + +V H H P + S
Sbjct: 3680 SAHGQAGPHQQSHQESTRGRSAGRSGRSGSFLYQVSTHEQSESAHGRAGPSTGGRQGSRH 3739
Query: 433 ELGHQAPSHRQSHQDEET--GH------GQRGSIKEMS---------HHPPGHTVVKDRS 475
E + H S + ++T GH G++GS E S HH HT + RS
Sbjct: 3740 EQARDSSRHSASQEGQDTIRGHPGSRRGGRQGSYHEQSVDRSGHSGSHH--SHTTSQGRS 3797
Query: 476 HLRKDDSEEEKEKEEDPGSHEEDDESSEQGEKGTHH-------GSRDQEDEEDEEEGHGL 528
S E + D S G + HH SR + + E G
Sbjct: 3798 DASHGQSGSRSASRETRNEEQSGDGSRHSGSR--HHEASTQADSSRHSQSGQGESAGSRR 3855
Query: 529 SLNQEEEEEEDKEEEEEEEDEERREERAEVGAPLSPDHSEEEEEEEEG 576
S Q +D + E ED ERR E A H E+ +G
Sbjct: 3856 SRRQGSSVSQDSDSEAYPEDSERRSESAS-----RNHHGSSREQSRDG 3898
Score = 90.9 bits (224), Expect = 4e-18
Identities = 138/624 (22%), Positives = 205/624 (32%), Gaps = 95/624 (15%)
Query: 27 TQQLRGDG-LGFRNRNNSTGVAGLSEEASAELRHHLH--SPRDHPDE-NKDVSTENGHHF 82
TQ + G G G R +++ G S E S L+ S + PD + T G
Sbjct: 434 TQSVSGHGKAGLRQQSHQESTRGRSGERSGRSGSSLYQVSTHEQPDSAHGRTGTSTGGRQ 493
Query: 83 WSHPDREKEDEDVSKEYGHLLPGHRSQDHKVGDEGVSGEEVFAEHGGQARGHRGHGSEDT 142
SH ++ ++ S H EG ++ H G +RG R GS
Sbjct: 494 GSHHEQARD----------------SSRHSASQEG---QDTIRGHPGSSRGGR-QGSHH- 532
Query: 143 EDSAEHRHHLPSHRSHSHQDEDEDEVVSSEHHHHILRHGHRGHDGEDDEGEEEEEEEEEE 202
E S H SH SH+ D + H R R E+ G+
Sbjct: 533 EQSVNRSGHSGSHHSHTTSQGRSD----ASHGQSGSRSASRQTRNEEQSGDGTRHSGSRH 588
Query: 203 EEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGP-SHRHQGHEEDDDDDDDDDDDDDDDD 261
EAS++ H G G GP + R+QG D D +D +
Sbjct: 589 HEASSQADSSRHSQVGQGQSS-----------GPRTSRNQGSSVSQDSDSQGHSEDSE-- 635
Query: 262 VSIEYRHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSHEEDDNDDDDVSTEYGHQAHRH 321
+ A R+ HG +++ RD S RSH ED + RH
Sbjct: 636 ---RWSGSASRNH-HGSAQEQS-------RDGSRHPRSHHEDRAGHGHSADSSRKSGTRH 684
Query: 322 QDHRKEEVEAVSGEHHHHVPDHRHQGHRDEEEDEDVSTERWHQGPQHVHHGLVDEEEEEE 381
+ A S E RH G R + + D S H G HG +
Sbjct: 685 TQNSSSGQAASSHEQARSSAGERH-GSRHQLQSADSSR---HSG---TGHGQASSAVRDS 737
Query: 382 EITVQFGHYVASHQPRGHKSDEEDFQDEYKTEVPHHH--HHRVPREEDEEVSAELG---H 436
G + GH D + + HH H R+ E S G +
Sbjct: 738 GHRGSSGSQATDSE--GHSEDSDTQSVSGHGQAGHHQQSHQESARDRSGERSRRSGSFLY 795
Query: 437 QAPSHRQSHQDEETGHGQRG---SIKEMSHHPPGHTVVKDRS-HLRKDDSEEE------K 486
Q +H+QS E+ HG G +++ SHH +D S H D ++
Sbjct: 796 QVSTHKQS----ESSHGWTGPSTGVRQGSHHEQ----ARDNSRHSASQDGQDTIRGHPGS 847
Query: 487 EKEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEEEDKEEEEEE 546
+ GSH E G G+HH + D G S + +++ +
Sbjct: 848 SRRGRQGSHHE-QSVDRSGHSGSHHSHTTSQGRSDASRGQSGSRSASRTTRNEEQSRDGS 906
Query: 547 EDEERREERAEVGAPLSPDHSEEEEEEEEGLEEDEPRFTIIPNPLDRREEAGGASSEEES 606
R A A +S HS+ + + EG + + + D E SE S
Sbjct: 907 RHSGSRHHEASSHADIS-RHSQAGQGQSEGSRTSRRQGSSVSQ--DSDSEGHSEDSERWS 963
Query: 607 GEDT-----GPQDAQEYGNYQPGS 625
G + Q+ +G+ P S
Sbjct: 964 GSASRNHRGSAQEQSRHGSRHPRS 987
Score = 90.9 bits (224), Expect = 4e-18
Identities = 128/653 (19%), Positives = 200/653 (30%), Gaps = 101/653 (15%)
Query: 65 RDHPDENKDVSTENGHHFWSHPDREKEDEDVSKEYGHLLPGHR---------SQDHKVGD 115
+ H + + S E H S + E +G P R +QD
Sbjct: 2718 QSHQESARGRSGETSGHSGSFLYQVSTHEQSESSHGWTGPSTRGRQGSRHEQAQDSSRHS 2777
Query: 116 EGVSGEEVFAEHGGQARG-----HRGHGSEDTEDSAEHRHHLPSH------------RSH 158
G++ H G +RG H H + + S H H S RS
Sbjct: 2778 ASQDGQDTIRGHPGSSRGGRQGYHHEHSVDSSGHSGSHHSHTTSQGRSDASRGQSGSRSA 2837
Query: 159 SHQDEDEDEVVSSEHH----HH-------ILRH---------GHRGHDGEDDEGEEEEEE 198
S +E++ H HH I RH G R + ++ +
Sbjct: 2838 SRTTRNEEQSGDGSRHSGSRHHEASTHADISRHSQAVQGQSEGSRRSRRQGSSVSQDSDS 2897
Query: 199 EEEEEEASTEYGHQAHRHRGHGSEEDEDVSD----------GHHHHGPSHRHQGHEEDDD 248
E E++ G + H G E+ D S GH H S R G
Sbjct: 2898 EGHSEDSERWSGSASRNHHGSAQEQLRDGSRHPRSHQEDRAGHGHSADSSRQSGTRHTQT 2957
Query: 249 DDDDDDDDDDDDD-VSIEYRHQAH--------RHQGHGIEEDEDVSDGHHHRDPSHRHRS 299
+ S RH +H RH G G + HR S S
Sbjct: 2958 SSGGQAASSHEQARSSAGERHGSHHQQSADSSRHSGIGHGQASSAVRDSGHRGYSGSQAS 3017
Query: 300 HEEDDNDDDDVSTEYGH-QAHRHQDHRKEEVEAVSGEHHHHVPDHRHQGHRDEEEDEDVS 358
E ++D D + H QA HQ +E SGE H +Q E+ +
Sbjct: 3018 DNEGHSEDSDTQSVSAHGQAGSHQQSHQESARGRSGETSGHSGSFLYQVSTHEQSESSHG 3077
Query: 359 ----TERWHQGPQHVHHGLVDEEEEEEEITVQFGHYVASHQPRGHKSDEEDFQDEYKTEV 414
+ R QG +H ++ Q+G P + + + E+ +
Sbjct: 3078 WTGPSTRGRQGSRH-----EQAQDSSRHSASQYGQDTIRGHPGSSRGGRQGYHHEHSVDS 3132
Query: 415 PHH---HHHRVPREEDEEVSAELGHQAPSHRQSHQDEETGHGQRGSIKEMSHHPPGHTVV 471
H HH + + S + R + +E++G R S+ H H +
Sbjct: 3133 SGHSGSHHSHTTSQGRSDASRGQSGSRSASRTTRNEEQSGDSSRHSVSR-HHEASTHADI 3191
Query: 472 KDRSHLRKDDSEEEK---------EKEEDPGSHEEDDE----SSEQGEKG-----THHGS 513
S + SE + ++ D H ED E S+ + +G + HGS
Sbjct: 3192 SRHSQAVQGQSEGSRRSRRQGSSVSQDSDSEGHSEDSERWSGSASRNHRGSVQEQSRHGS 3251
Query: 514 RDQEDEEDEEEGHGLSLNQEEEEEEDKEEEEEEEDEERREERAEVGAPLSPDHSEEEEEE 573
R ++ GHG S ++ + E E+A +P S ++
Sbjct: 3252 RHPRSHHEDRAGHGHSADRSRQSGTRHAETSSGGQAASSHEQAR-SSPGERHGSRHQQSA 3310
Query: 574 EEGLEEDEPRFTIIPNPLDRR---EEAGGASSEEESGEDTGPQDAQEYGNYQP 623
+ PR D R AS E E++ Q +G P
Sbjct: 3311 DSSRHSGIPRGQASSAVRDSRHWGSSGSQASDSEGHSEESDTQSVSGHGQAGP 3363
Score = 90.5 bits (223), Expect = 5e-18
Identities = 128/653 (19%), Positives = 197/653 (30%), Gaps = 81/653 (12%)
Query: 40 RNNSTGVAGLSEEASAELRHHLHSPRDHPDENKDVSTENGHHFWSHPDREKEDEDVSKEY 99
R S G +G S ++ H S H G H R+ S+E
Sbjct: 2401 RGRSAGRSGRSGSFLYQVSTHEQSESAHGRTGTSTGGRQGSHH--KQARDSSRHSTSQEG 2458
Query: 100 GHLLPGHRSQDHKVGDEGVSGEEVFAEHGGQARGHRGHGSEDTEDSAEHRHHLPSHRSHS 159
+ GH G S E + G + H H + A H H RS S
Sbjct: 2459 QDTIHGHPGSSS--GGRQGSHYEQLVDRSGHSGSHHSHTTSQGRSDASHGHS--GSRSAS 2514
Query: 160 HQDEDEDEV------VSSEHHHHILRHGHRGHD--GE-DDEG-----------EEEEEEE 199
Q ++++ S HH R GH G+ EG ++ + +
Sbjct: 2515 RQTRNDEQSGDGSRHSGSRHHEASSRADSSGHSQVGQGQSEGPRTSRNWGSSFSQDSDSQ 2574
Query: 200 EEEEEASTEYGHQAHRHRGHGSEEDEDVSD----------GHHHHGPSHRHQGHEEDDDD 249
E++ G + H G E+ D S GH H S R G
Sbjct: 2575 GHSEDSERWSGSASRNHHGSAQEQLRDGSRHPRSHQEDRAGHGHSADSSRQSGTRHTQTS 2634
Query: 250 DDDDDDDDDDDD-VSIEYRHQAH--------RHQGHGIEEDEDVSDGHHHRDPSHRHRSH 300
+ S RH +H RH G G + HR S S
Sbjct: 2635 SGGQAASSHEQARSSAGERHGSHHQQSADSSRHSGIGHGQASSAVRDSGHRGYSGSQASD 2694
Query: 301 EEDDNDDDDVSTEYGH-QAHRHQDHRKEEVEAVSGEHHHHVPDHRHQGHRDEEEDEDVS- 358
E ++D D + H QA HQ +E SGE H +Q E+ +
Sbjct: 2695 NEGHSEDSDTQSVSAHGQAGSHQQSHQESARGRSGETSGHSGSFLYQVSTHEQSESSHGW 2754
Query: 359 ---TERWHQGPQHVHHGLVDEEEEEEEITVQFGHYVASHQPRGHKSDEEDFQDEYKTEVP 415
+ R QG +H ++ Q G P + + + E+ +
Sbjct: 2755 TGPSTRGRQGSRH-----EQAQDSSRHSASQDGQDTIRGHPGSSRGGRQGYHHEHSVDSS 2809
Query: 416 HH---HHHRVPREEDEEVSAELGHQAPSHRQSHQDEETGHGQRGSIKEMSHHPPGHTVVK 472
H HH + + S + R + +E++G G R S H H +
Sbjct: 2810 GHSGSHHSHTTSQGRSDASRGQSGSRSASRTTRNEEQSGDGSRHS-GSRHHEASTHADIS 2868
Query: 473 DRSHLRKDDSEEEK---------EKEEDPGSHEEDDESSEQGEKGTHH---------GSR 514
S + SE + ++ D H ED E HH GSR
Sbjct: 2869 RHSQAVQGQSEGSRRSRRQGSSVSQDSDSEGHSEDSERWSGSASRNHHGSAQEQLRDGSR 2928
Query: 515 DQEDEEDEEEGHGLSLNQEEEE--EEDKEEEEEEEDEERREERAEVGAPLSPDHSEEEEE 572
+++ GHG S + + + + + R+ G H + +
Sbjct: 2929 HPRSHQEDRAGHGHSADSSRQSGTRHTQTSSGGQAASSHEQARSSAGERHGSHHQQSADS 2988
Query: 573 EEEGLEEDEPRFTIIPNPLDRREEAGGASSEEESGEDTGPQDAQEYGNYQPGS 625
+ + + R AS E ED+ Q +G Q GS
Sbjct: 2989 SRHSGIGHGQASSAVRDSGHRGYSGSQASDNEGHSEDSDTQSVSAHG--QAGS 3039
Score = 85.5 bits (210), Expect = 2e-16
Identities = 121/638 (18%), Positives = 185/638 (28%), Gaps = 89/638 (13%)
Query: 62 HSPRDHPDENKDVSTENGHHFWSHP-----DREKEDEDVSKEYGHLLPGHRSQDHKVGDE 116
HS H + V ++GH +S + ED D H G Q H+
Sbjct: 2991 HSGIGHGQASSAVR-DSGHRGYSGSQASDNEGHSEDSDTQSVSAHGQAGSHQQSHQESAR 3049
Query: 117 GVSGE----------------EVFAEHGG---QARGHRGHGSEDTEDSAEH--------- 148
G SGE + + HG RG +G E +DS+ H
Sbjct: 3050 GRSGETSGHSGSFLYQVSTHEQSESSHGWTGPSTRGRQGSRHEQAQDSSRHSASQYGQDT 3109
Query: 149 -RHHLPSHRS----HSHQDEDEDEVVSSEHHHHILRHGHRGHDGEDDEGEEEEEEEEEEE 203
R H S R + H+ + S HH H G EE
Sbjct: 3110 IRGHPGSSRGGRQGYHHEHSVDSSGHSGSHHSHTTSQGRSDASRGQSGSRSASRTTRNEE 3169
Query: 204 EASTEYGHQAHRHRGHGSEEDEDVS------DGHHHHGPSHRHQGHEEDDDDDDDDDDDD 257
++ H RH H + D+S G R QG D D + +D
Sbjct: 3170 QSGDSSRHSVSRH--HEASTHADISRHSQAVQGQSEGSRRSRRQGSSVSQDSDSEGHSED 3227
Query: 258 DD---DDVSIEYRHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSHEEDDNDDDDVSTEY 314
+ S +R HG HH H H + + T
Sbjct: 3228 SERWSGSASRNHRGSVQEQSRHGSRHPRS----HHEDRAGHGHSADRSRQSGTRHAETSS 3283
Query: 315 GHQA-HRHQDHRKEEVEAVSGEHHHHVPDHRHQGHRDEEEDEDVSTERWHQGPQHVHHGL 373
G QA H+ R E H RH G + V R H G
Sbjct: 3284 GGQAASSHEQARSSPGERHGSRHQQSADSSRHSGIPRGQASSAVRDSR-HWGSSGSQASD 3342
Query: 374 VDEEEEEEEITVQFGHYVASHQPRGHKSDEEDFQDEYKTEVPHHHHHRVPREEDEEVSAE 433
+ EE + GH A + H+ D + E+ E
Sbjct: 3343 SEGHSEESDTQSVSGHGQAGPHQQSHQESARDRSGGRSGRSGSFLYQVSTHEQSESAHGR 3402
Query: 434 L----GHQAPSHRQSHQDEETGHGQRGSIKEMSHHPPGHTVVKDRSHLRKDDSEEEKEKE 489
G + SH + +D + + HP + SH E+ ++
Sbjct: 3403 TRTSTGRRQGSHHEQARDSSRHSASQEGQDTIRGHPGSSRRGRQGSHY-----EQSVDRS 3457
Query: 490 EDPGSHEEDDES-----SEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEEEDKEEEE 544
GSH S + +G+ G+ SR + DE+ G G + E + +
Sbjct: 3458 GHSGSHHSHTTSQGRSDASRGQSGSRSASR--QTRNDEQSGDGSRHSWSHHHEASTQADS 3515
Query: 545 EEEDEERREERAEVGAPLSPDHSEEEEEEEEGLEEDEPRFTIIP---------------- 588
+ + + A + S ++ + +G ED R++
Sbjct: 3516 SRHSQSGQGQSAGPRTSRNQGSSVSQDSDSQGHSEDSERWSGSASRNHRGSAQEQSRDGS 3575
Query: 589 -NPLDRREEAGGASSEEESGEDTGPQDAQEYGNYQPGS 625
+P E+ G ES +G A+ Q S
Sbjct: 3576 RHPTSHHEDRAGHGHSAESSRQSGTHHAENSSGGQAAS 3613
Score = 84.7 bits (208), Expect = 3e-16
Identities = 138/683 (20%), Positives = 208/683 (30%), Gaps = 123/683 (18%)
Query: 41 NNSTGVAGLSEE---ASAELRHHLHSPRDHPDENK----------DVSTENGHHFWS--- 84
++S G A S E +SA RH H D ++ ++GH +S
Sbjct: 1984 SSSRGQAASSHEQARSSAGERHGSHHQLQSADSSRHSGIGHGQASSAVRDSGHRGYSGSQ 2043
Query: 85 --HPDREKEDEDVSKEYGHLLPGHRSQDHKVGDEGVSG----------------EEVFAE 126
+ ED D G Q HK G SG E+ +
Sbjct: 2044 ASDSEGHSEDSDTQSVSAQGKAGPHQQSHKESARGQSGESSGRSGSFLYQVSTHEQSEST 2103
Query: 127 HGGQA---RGHRGHGSEDTEDSAEHR-----------HHLPSH--RSHSHQDEDEDEV-V 169
HG A G +G + +DS+ H H PS R SHQ++ D
Sbjct: 2104 HGQSAPSTGGRQGSHYDQAQDSSRHSASQEGQDTIRGHPGPSRGGRQGSHQEQSVDRSGH 2163
Query: 170 SSEHHHHILRHGH----RGHDGEDDEGEEEEEEEEEEEEASTEYGHQAHRHRGHGSEEDE 225
S HH H G RG G + ++E+ + + H S
Sbjct: 2164 SGSHHSHTTSQGRSDASRGQSGSRSASRKTYDKEQSGDGSRHSGSHHHEASSWADSSRHS 2223
Query: 226 DVSDGHHHHGPSHRHQGHEEDDDDDDDDDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVS 285
V G + R +G D D + +D + R+ H G E+ D S
Sbjct: 2224 LVGQGQSSGPRTSRPRGSSVSQDSDSEGHSEDSERRSGSASRN----HHGSAQEQSRDGS 2279
Query: 286 ---DGHHHRDPSHRHRSHEEDDNDDDDVSTEYGHQAHRHQDHRKEEVEAVSGEHHHHVPD 342
HH H H + + G QA + + G HH D
Sbjct: 2280 RHPRSHHEDRAGHGHSAESSRQSGTHHAENSSGGQAASSHEQARSSAGERHGSHHQQSAD 2339
Query: 343 ---HRHQGHRDEEEDEDVSTERWHQGPQHVHHGLVDEEEEEEEITV--QFGHYVASHQ-- 395
H GH S R G Q E+ + + ++ Q G + SHQ
Sbjct: 2340 SSRHSGIGHGQASSAVRDSGHRGSSGSQASDSEGHSEDSDTQSVSAHGQAGPHQQSHQES 2399
Query: 396 PRGHKSDEEDFQDEYKTEVPHHHHHRVPREEDEEVSAELGHQAPSHRQ---------SHQ 446
RG + + +V H ++ G Q H+Q S +
Sbjct: 2400 TRGRSAGRSGRSGSFLYQVSTHEQSE--SAHGRTGTSTGGRQGSHHKQARDSSRHSTSQE 2457
Query: 447 DEETGHGQRGSIK-----------------EMSHHPPGHTVVKDRSHLRKDDSEEEKEKE 489
++T HG GS SHH HT + RS S
Sbjct: 2458 GQDTIHGHPGSSSGGRQGSHYEQLVDRSGHSGSHH--SHTTSQGRSDASHGHSGSRSASR 2515
Query: 490 EDPGSHEEDDESSEQGEKGTHHGSRDQEDE-------EDEEEGHGLSLNQEEEEEEDKEE 542
+ + D S G + HH + + D + + EG S N +D +
Sbjct: 2516 QTRNDEQSGDGSRHSGSR--HHEASSRADSSGHSQVGQGQSEGPRTSRNWGSSFSQDSDS 2573
Query: 543 EEEEEDEERREERAEVGAPLSPDHSEEEEEEEEGLEEDEPRFTIIPNPLDRREEAGGASS 602
+ ED ER G+ H +E+ +G +P +E+ G
Sbjct: 2574 QGHSEDSERWS-----GSASRNHHGSAQEQLRDGSR----------HPRSHQEDRAGHGH 2618
Query: 603 EEESGEDTGPQDAQEYGNYQPGS 625
+S +G + Q Q S
Sbjct: 2619 SADSSRQSGTRHTQTSSGGQAAS 2641
Score = 79.3 bits (194), Expect = 1e-14
Identities = 115/565 (20%), Positives = 174/565 (30%), Gaps = 92/565 (16%)
Query: 71 NKDVSTENGHHFWSHPDREKEDEDVSKEYGHLLPGH---------RSQDHKVGDEGVS-- 119
+K+ S + H SH D S+ H L G R + V + S
Sbjct: 2195 DKEQSGDGSRHSGSHHHEASSWADSSR---HSLVGQGQSSGPRTSRPRGSSVSQDSDSEG 2251
Query: 120 -GEEVFAEHGGQARGHRGHGSEDTEDSAEH-RHHLPSHRSHSHQDEDEDEVVSSEHHHHI 177
E+ G +R H G E + D + H R H H H E + S HH
Sbjct: 2252 HSEDSERRSGSASRNHHGSAQEQSRDGSRHPRSHHEDRAGHGHSAESSRQ--SGTHHAEN 2309
Query: 178 LRHGHRGHDGEDDEGEEEEEEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPS 237
G E E ++++ H GHG GH S
Sbjct: 2310 SSGGQAASSHEQARSSAGERHGSHHQQSADSSRHSGI---GHGQASSAVRDSGHRGSSGS 2366
Query: 238 HRH--QGHEEDDDDDDDDDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDGHHHRDPSH 295
+GH ED D S+ QA HQ E S G R S
Sbjct: 2367 QASDSEGHSEDSDTQ------------SVSAHGQAGPHQQSHQESTRGRSAGRSGRSGSF 2414
Query: 296 RHR--SHEEDDNDDDDVSTEY-GHQAHRHQDHRKEEVEAVSGEHHHHVPDH--RHQGHRD 350
++ +HE+ ++ T G Q H+ R + S E + H G R
Sbjct: 2415 LYQVSTHEQSESAHGRTGTSTGGRQGSHHKQARDSSRHSTSQEGQDTIHGHPGSSSGGRQ 2474
Query: 351 EEEDEDVSTERWHQGPQHVHHGLVDEEEEEEEITVQFGHYVASHQPRGHKSDEEDFQDEY 410
E + H G H H + GH + R ++DE+
Sbjct: 2475 GSHYEQLVDRSGHSGSHHSH------TTSQGRSDASHGHSGSRSASRQTRNDEQSGDGSR 2528
Query: 411 KTEVPHHH---------HHRVPREEDE-------------EVSAELGHQAPSHRQSHQDE 448
+ HH H +V + + E + S GH S R S
Sbjct: 2529 HSGSRHHEASSRADSSGHSQVGQGQSEGPRTSRNWGSSFSQDSDSQGHSEDSERWSGSAS 2588
Query: 449 ETGHGQ-RGSIKEMSHHPPGHTVVKDRS-HLRKDDSEEE---KEKEEDPGSHEEDDESSE 503
HG + +++ S HP H +DR+ H DS + + + G
Sbjct: 2589 RNHHGSAQEQLRDGSRHPRSHQ--EDRAGHGHSADSSRQSGTRHTQTSSGGQAASSHEQA 2646
Query: 504 QGEKGTHHGSRDQEDEEDEEE---GHGLSLNQEEE---------EEEDKEEEEEEEDEER 551
+ G HGS Q+ + GHG + + + + D E E+ D +
Sbjct: 2647 RSSAGERHGSHHQQSADSSRHSGIGHGQASSAVRDSGHRGYSGSQASDNEGHSEDSDTQS 2706
Query: 552 REERAEVGAPLSPDHSEEEEEEEEG 576
+ G+ H + +E G
Sbjct: 2707 VSAHGQAGS-----HQQSHQESARG 2726
Score = 77.0 bits (188), Expect = 5e-14
Identities = 142/676 (21%), Positives = 199/676 (29%), Gaps = 119/676 (17%)
Query: 45 GVAGLSEEASAELRHHLHSPRDHPDENKDVSTENGHHFWSHPDREKEDEDVSKEYGHLLP 104
G G E S H S H +G R+ +E+ S + G
Sbjct: 526 GRQGSHHEQSVNRSGHSGSHHSHTTSQGRSDASHGQSGSRSASRQTRNEEQSGD-GTRHS 584
Query: 105 GHRSQDHKVGDEGVSGEEVFAEHGGQARGHRGHGSEDTEDSAEHRHHLPSHR-----SHS 159
G R + + +V R R GS ++DS H S R S +
Sbjct: 585 GSRHHEASSQADSSRHSQVGQGQSSGPRTSRNQGSSVSQDSDSQGHSEDSERWSGSASRN 644
Query: 160 HQDEDEDEVVSSEHH---HHILRHGHRGH--DGEDDEGEEEEEEEEEEEEASTEYGHQAH 214
H +++ H HH R GH GH D G + + AS+ ++
Sbjct: 645 HHGSAQEQSRDGSRHPRSHHEDRAGH-GHSADSSRKSGTRHTQNSSSGQAASSHEQARSS 703
Query: 215 RHRGHGSEEDEDVSDGHHHHGPSH-------RHQGHEEDDDDD--DDDDDDDDDDDVSIE 265
HGS +D H G H R GH D + +D D S+
Sbjct: 704 AGERHGSRHQLQSADSSRHSGTGHGQASSAVRDSGHRGSSGSQATDSEGHSEDSDTQSVS 763
Query: 266 YRHQAHRHQGHGIEEDEDVS--------------DGHHHRDPSH---------RHRSHEE 302
QA HQ E D S H + SH R SH E
Sbjct: 764 GHGQAGHHQQSHQESARDRSGERSRRSGSFLYQVSTHKQSESSHGWTGPSTGVRQGSHHE 823
Query: 303 DDNDD-------DDVSTEYGHQAH----RHQDHRKEEVEAV--SGEHHHHVPDHRHQGH- 348
D+ D T GH R H ++ V+ SG HH H
Sbjct: 824 QARDNSRHSASQDGQDTIRGHPGSSRRGRQGSHHEQSVDRSGHSGSHHSHTTSQGRSDAS 883
Query: 349 -------------RDEEEDEDVSTE---RWHQGPQHV----HHGLVDEEEEEEEITVQFG 388
R+EE+ D S R H+ H H + E + + G
Sbjct: 884 RGQSGSRSASRTTRNEEQSRDGSRHSGSRHHEASSHADISRHSQAGQGQSEGSRTSRRQG 943
Query: 389 HYVASHQP-RGHKSDEEDFQDEYKTEVPHHHHHRVPREEDEEVSAELGHQAPSHRQSHQD 447
V+ GH D E + +HR +E + H +SH +
Sbjct: 944 SSVSQDSDSEGHSEDSERWSGSAS------RNHRGSAQEQSRHGSR-------HPRSHHE 990
Query: 448 EETGHGQRGSIKEMSHHPPGHTVVKDRSHLRKDDSEEEKEKEEDPGS-HEEDDESSEQGE 506
+ GHG S P H + E GS H++ +SS
Sbjct: 991 DRAGHGHSADSSRQSGTP--HAETSSGGQAASSHEQARSSPGERHGSRHQQSADSSR--- 1045
Query: 507 KGTHHG-SRDQEDEEDEEEGHGLSLNQEEEEEEDKEEEEEEEDEERREERAEVGAPLSPD 565
H G R Q + GH + D E EE D + + G P
Sbjct: 1046 ---HSGIPRRQASSAVRDSGH---WGSSGSQASDSEGHSEESDTQSVSGHGQDG-PHQQS 1098
Query: 566 HSEEEEEEEEGLEEDEPRFTIIPNPLDRREEAGGAS---------SEEESGEDTGPQDAQ 616
H E + G F + ++ E A G + S E D+ A
Sbjct: 1099 HQESARDWSGGRSGRSGSFIYQVSTHEQSESAHGRTRTSTGRRQGSHHEQARDSSRHSAS 1158
Query: 617 EYG----NYQPGSLCG 628
+ G PGS G
Sbjct: 1159 QEGQDTIRAHPGSRRG 1174
Score = 77.0 bits (188), Expect = 5e-14
Identities = 132/663 (19%), Positives = 193/663 (29%), Gaps = 148/663 (22%)
Query: 85 HPDREKEDEDVSKEYGHLLPGHRSQDHKVGDEGVSGEEVFAEHGGQARGHRGHGSE-DTE 143
H R ++ D S + G G R VGD G G G QA GH E DT+
Sbjct: 1681 HGSRHQQSADSSTDSG---TGRRQDSSVVGDSGNRGSS-----GSQASDSEGHSEESDTQ 1732
Query: 144 DSAEHRHHLPSHRSHSHQDEDEDEVVS----------SEHHHHILRHGHRGHD-GEDDEG 192
+ H P +SH + S S H HG G G
Sbjct: 1733 SVSAHGQAGPHQQSHQESTRGQSGERSGRSGSFLYQVSTHEQSESAHGRTGPSTGGRQRS 1792
Query: 193 EEEEEEEEEEEEASTE-----YGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEEDD 247
E+ + AS E GH G E D H G H H +E
Sbjct: 1793 RHEQARDSSRHSASQEGQDTIRGHPGSSRGGRQGSHYEQSVDSSGHSGSHHSHTTSQE-- 1850
Query: 248 DDDDDDDDDDDDDDVSIEYRHQ-----AHRHQGHGIEEDEDVSDGHHHRDPSHRHRSHEE 302
D VS + R++ RH G E +D H S
Sbjct: 1851 -RSDVSRGQSGSRSVSRQTRNEKQSGDGSRHSGSRHHEASSRADSSRHSQVGQGQSSGPR 1909
Query: 303 DD-NDDDDVSTEYGHQAHRHQDHR----------------KEEVEAVSGEHH-------H 338
N VS + Q H R + G HH H
Sbjct: 1910 TSRNQGSSVSQDSDSQGHSEDSERWSGSASRNHLGSAWEQSRDGSRHPGSHHEDRAGHGH 1969
Query: 339 HVPDHRHQGHRDEEEDEDVSTERWHQ------GPQHVHHGLVDEEEEEEEITVQFGHYVA 392
R G R E H+ G +H H + + + G +
Sbjct: 1970 SADSSRQSGTRHTESSSRGQAASSHEQARSSAGERHGSHHQLQSADSSRHSGIGHGQASS 2029
Query: 393 SHQPRGHK-------SDEEDFQDEYKTEV--------PHHHHHR-VPREEDEEVSAELG- 435
+ + GH+ SD E ++ T+ PH H+ R + E S G
Sbjct: 2030 AVRDSGHRGYSGSQASDSEGHSEDSDTQSVSAQGKAGPHQQSHKESARGQSGESSGRSGS 2089
Query: 436 --HQAPSHRQSH----QDEETGHGQRGSIKEMSHHPPGHTVVKD------------RSHL 477
+Q +H QS Q + G++GS + + H+ ++ R
Sbjct: 2090 FLYQVSTHEQSESTHGQSAPSTGGRQGSHYDQAQDSSRHSASQEGQDTIRGHPGPSRGGR 2149
Query: 478 RKDDSEEEKEKEEDPGSHEEDDES-----SEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQ 532
+ E+ ++ GSH S + +G+ G+ SR D+E +G S +
Sbjct: 2150 QGSHQEQSVDRSGHSGSHHSHTTSQGRSDASRGQSGSRSASRKTYDKEQSGDGSRHSGSH 2209
Query: 533 EEEE------------------------------EEDKEEEEEEEDEERREERAEVGAPL 562
E +D + E ED ERR G+
Sbjct: 2210 HHEASSWADSSRHSLVGQGQSSGPRTSRPRGSSVSQDSDSEGHSEDSERRS-----GSAS 2264
Query: 563 SPDHSEEEEEEEEGLEEDEPRFTIIPNPLDRREEAGGASSEEESGEDTGPQDAQEYGNYQ 622
H +E+ +G +P E+ G ES +G A+ Q
Sbjct: 2265 RNHHGSAQEQSRDGSR----------HPRSHHEDRAGHGHSAESSRQSGTHHAENSSGGQ 2314
Query: 623 PGS 625
S
Sbjct: 2315 AAS 2317
Score = 77.0 bits (188), Expect = 5e-14
Identities = 117/632 (18%), Positives = 196/632 (31%), Gaps = 72/632 (11%)
Query: 40 RNNSTGVAGLSEEASAELRHHLHSPRDHPDENKDVSTENGHHFWSHPDREKEDEDVSKEY 99
R+ S G +G S ++ H S H G H R+ S+E
Sbjct: 3373 RDRSGGRSGRSGSFLYQVSTHEQSESAHGRTRTSTGRRQGSHH--EQARDSSRHSASQEG 3430
Query: 100 GHLLPGHRSQDHKVGDEGVSGEEVFAEHGGQARGHRGHGSEDTEDSAEHRHHLPSHRSHS 159
+ GH + G +G S E + G + H H + A RS S
Sbjct: 3431 QDTIRGHPGSSRR-GRQG-SHYEQSVDRSGHSGSHHSHTTSQGRSDASRGQS--GSRSAS 3486
Query: 160 HQDEDEDEVV-----SSEHHHHILRHGHRGHDGEDDEGE---------------EEEEEE 199
Q ++++ S HHH + +G+ ++ + +
Sbjct: 3487 RQTRNDEQSGDGSRHSWSHHHEASTQADSSRHSQSGQGQSAGPRTSRNQGSSVSQDSDSQ 3546
Query: 200 EEEEEASTEYGHQAHRHRGHGSEEDEDVSD----------GHHHHGPSHRHQG-HEEDDD 248
E++ G + HRG E+ D S GH H S R G H ++
Sbjct: 3547 GHSEDSERWSGSASRNHRGSAQEQSRDGSRHPTSHHEDRAGHGHSAESSRQSGTHHAENS 3606
Query: 249 DDDDDDDDDDDDDVSIEYRHQAH--------RHQGHGIEEDEDVSDGHHHRDPSHRHRSH 300
+ S RH +H RH G G + HR S S
Sbjct: 3607 SGGQAASSHEQARSSAGERHGSHHQQSADSSRHSGIGHGQASSAVRDSGHRGSSGSQASD 3666
Query: 301 EEDDNDDDDVSTEYGH-QAHRHQDHRKEEVEAVSGEHHHHVPDHRHQGHRDEEEDEDVS- 358
E ++D D + H QA HQ +E S +Q E+ +
Sbjct: 3667 SEGHSEDSDTQSVSAHGQAGPHQQSHQESTRGRSAGRSGRSGSFLYQVSTHEQSESAHGR 3726
Query: 359 ---TERWHQGPQH--VHHGLVDEEEEEEEITVQFGHYVASHQPRGHKSDEEDFQDEYKTE 413
+ QG +H +E + T++ GH + G + + +
Sbjct: 3727 AGPSTGGRQGSRHEQARDSSRHSASQEGQDTIR-GH--PGSRRGGRQGSYHEQSVDRSGH 3783
Query: 414 VPHHHHHRVPREEDEEVSAELGHQAPSHRQSHQDEETGHGQRGSIKEMSHHPPGHTVVKD 473
HH H + + + G ++ S R++ +E++G G R S
Sbjct: 3784 SGSHHSHTTSQGRSDASHGQSGSRSAS-RETRNEEQSGDGSRHS--------------GS 3828
Query: 474 RSHLRKDDSEEEKEKEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQE 533
R H ++ + + G S QG + + E+ E S N
Sbjct: 3829 RHHEASTQADSSRHSQSGQGESAGSRRSRRQGSSVSQDSDSEAYPEDSERRSESASRNHH 3888
Query: 534 EEEEEDKEEEEEEEDEERREERAEVGAPLSPDHSEEEEEEEEGLEEDEPRFTIIPNPLDR 593
E + R+ + V + SP S+ +E G + + + +
Sbjct: 3889 GSSREQSRDGSRHPGSSHRDTASHVQS--SPVQSDSSTAKEHGHFSSLSQDSAYHSGIQS 3946
Query: 594 REEAGGASSEEESGEDTGPQDAQEYGNYQPGS 625
R +SS E T Q Q ++ GS
Sbjct: 3947 RGSPHSSSSYHYQSEGTERQKGQSGLVWRHGS 3978
Score = 59.3 bits (142), Expect = 1e-08
Identities = 117/612 (19%), Positives = 180/612 (29%), Gaps = 158/612 (25%)
Query: 155 HRSHSHQDEDEDEVVSSEHHHH------ILRHGHRGHDG-----EDDEGEEEEEEEEEEE 203
HR HSH D+ ED + R+ +G+ G + G+ E E++E
Sbjct: 101 HRKHSHHDKHEDNKQEENKENRKRPSSLERRNNRKGNKGRSKSPRETGGKRHESSSEKKE 160
Query: 204 -------EASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEEDDDDDDD---- 252
EYG H + E+ G + S R + E++++ D
Sbjct: 161 RKGYSPTHREEEYGKNHHNSSKKEKNKTENTRLGDNRKRLSERLEEKEDNEEGVYDYENT 220
Query: 253 -------------------DDDDDDDDDVSIE---------------------YRHQ--- 269
D+ D D +E RH+
Sbjct: 221 GRMTQKWIQSGHIATYYTIQDEAYDTTDSLLEENKIYERSRSSDGKSSSQVNRSRHENTS 280
Query: 270 --------AHRHQGHGIEEDEDVSDGH--------------HH-------RDPSHRHRSH 300
+ +G + +D D S+GH HH RD S RSH
Sbjct: 281 QVPLQESRTRKRRGSRVSQDRD-SEGHSEDSERHSGSASRNHHGSAWEQSRDGSRHPRSH 339
Query: 301 EEDDNDDDDVSTEYGHQAHRHQDHRKEEVEAVSGEHHHHVPDHRH-QGHRDEEEDEDVS- 358
+ED + RH + A S E P RH GH+ + S
Sbjct: 340 DEDRASHGHSADSSRQSGTRHAETSSRGQTASSHEQARSSPGERHGSGHQQSADSSRHSA 399
Query: 359 ----------TERWHQGPQHVHHGLVDEEEEEEEITVQFGHYVASHQPRGHKSDEEDFQD 408
++R H+G + E + GH A + + H+
Sbjct: 400 TGRGQASSAVSDRGHRGSSGSQASDSEGHSENSDTQSVSGHGKAGLRQQSHQESTRGRSG 459
Query: 409 EYK----TEVPHHHHHRVPREEDEEVSAELGHQAPSHR------------QSHQDEETGH 452
E + + H P G + SH Q QD GH
Sbjct: 460 ERSGRSGSSLYQVSTHEQPDSAHGRTGTSTGGRQGSHHEQARDSSRHSASQEGQDTIRGH 519
Query: 453 ------GQRGSIKEMSHHPPGHTVVKDRSHLRKDDSEEEKEKEEDPGSHEEDDESSEQGE 506
G++GS E S + GH+ SH + + S + EQ
Sbjct: 520 PGSSRGGRQGSHHEQSVNRSGHS-GSHHSHTTSQGRSDASHGQSGSRSASRQTRNEEQSG 578
Query: 507 KGTHH-GSRDQEDE------------EDEEEGHGLSLNQEEEEEEDKEEEEEEEDEERRE 553
GT H GSR E + + G S NQ +D + + ED ER
Sbjct: 579 DGTRHSGSRHHEASSQADSSRHSQVGQGQSSGPRTSRNQGSSVSQDSDSQGHSEDSERWS 638
Query: 554 ERAEVGAPLSPDHSEEEEEEEEGLEEDEPRFTIIPNPLDRREEAGGASSEEESGEDTGPQ 613
G+ H +E+ +G +P E+ G +S +G +
Sbjct: 639 -----GSASRNHHGSAQEQSRDGSR----------HPRSHHEDRAGHGHSADSSRKSGTR 683
Query: 614 DAQEYGNYQPGS 625
Q + Q S
Sbjct: 684 HTQNSSSGQAAS 695
Score = 42.0 bits (97), Expect = 0.002
Identities = 30/122 (24%), Positives = 53/122 (43%), Gaps = 8/122 (6%)
Query: 467 GHTVVKDRSHLRKDDSEEEKEKEEDPGSHEEDDESSEQGEKG-----THHGSRDQEDEED 521
GH K H + +D+++E+ KE + ++ +G KG G + E +
Sbjct: 98 GHKHRKHSHHDKHEDNKQEENKENRKRPSSLERRNNRKGNKGRSKSPRETGGKRHESSSE 157
Query: 522 EEEGHGLSLNQEEEEEEDKEEEEEEEDEERREERAEVG--APLSPDHSEEEEEEEEGLEE 579
++E G S EEE K + E+ + E +G + EE+E+ EEG+ +
Sbjct: 158 KKERKGYS-PTHREEEYGKNHHNSSKKEKNKTENTRLGDNRKRLSERLEEKEDNEEGVYD 216
Query: 580 DE 581
E
Sbjct: 217 YE 218
Score = 41.2 bits (95), Expect = 0.003
Identities = 61/304 (20%), Positives = 112/304 (36%), Gaps = 49/304 (16%)
Query: 321 HQDHRKEEVEAVSGEHHHHVPDHRHQGHRDEEEDED----VSTERWHQGPQHVHHGLVDE 376
++ RKE + +H H +H+ ++ EE E+ S ER ++ G
Sbjct: 86 YESTRKENLPISGHKHRKHSHHDKHEDNKQEENKENRKRPSSLER-----RNNRKGNKGR 140
Query: 377 EEEEEEITVQFGHYVASHQPRGHKSDEEDFQDEYK-TEVPHHHHHRVPREEDEEVSAELG 435
+ E + H+ K + + + ++ E +HH+ +E+++ + LG
Sbjct: 141 SKSPRETGGK------RHESSSEKKERKGYSPTHREEEYGKNHHNSSKKEKNKTENTRLG 194
Query: 436 ---HQAPSHRQSHQDEETG---HGQRGSIKE---MSHHPPGHTVVKDRSHLRKDDSEEEK 486
+ + +D E G + G + + S H + ++D ++ D EE
Sbjct: 195 DNRKRLSERLEEKEDNEEGVYDYENTGRMTQKWIQSGHIATYYTIQDEAYDTTDSLLEEN 254
Query: 487 EKEEDPGSHEEDDESSEQGEKGTHHGSRD---QEDEEDEEEGHGLSLNQEEEEEEDKEEE 543
+ E S D +SS Q + H + QE + G +S +D++ E
Sbjct: 255 KIYE--RSRSSDGKSSSQVNRSRHENTSQVPLQESRTRKRRGSRVS--------QDRDSE 304
Query: 544 EEEEDEERREERAEVGAPLSPDHSEEEEEEEEGLEEDEPRFTIIPNPLDRREEAGGASSE 603
ED ER G+ H E+ +G PR + DR A S
Sbjct: 305 GHSEDSERHS-----GSASRNHHGSAWEQSRDG--SRHPR----SHDEDRASHGHSADSS 353
Query: 604 EESG 607
+SG
Sbjct: 354 RQSG 357
Score = 30.0 bits (66), Expect = 7.6
Identities = 39/186 (20%), Positives = 55/186 (29%), Gaps = 37/186 (19%)
Query: 71 NKDVSTENGHHFWSHPDREKEDEDVSKE----YGHLLPGHRSQDHKVGDEGVSGEEVFAE 126
N++ S + H S D S+ G RS+ S E + E
Sbjct: 3815 NEEQSGDGSRHSGSRHHEASTQADSSRHSQSGQGESAGSRRSRRQGSSVSQDSDSEAYPE 3874
Query: 127 HGGQ-----ARGHRGHGSEDTEDSAEHRHHLPSHR---SHSHQDEDEDEVVSSEHHHHI- 177
+ +R H G E + D + RH SHR SH + + +++ H H
Sbjct: 3875 DSERRSESASRNHHGSSREQSRDGS--RHPGSSHRDTASHVQSSPVQSDSSTAKEHGHFS 3932
Query: 178 -LRHGHRGHDGEDDEGEEEEEEEEEEEEASTE---------------------YGHQAHR 215
L H G G + TE YG R
Sbjct: 3933 SLSQDSAYHSGIQSRGSPHSSSSYHYQSEGTERQKGQSGLVWRHGSYGSADYDYGESGFR 3992
Query: 216 HRGHGS 221
H HGS
Sbjct: 3993 HSQHGS 3998
>gi|217330641 IWS1 homolog [Homo sapiens]
Length = 819
Score = 89.0 bits (219), Expect = 1e-17
Identities = 120/536 (22%), Positives = 191/536 (35%), Gaps = 85/536 (15%)
Query: 115 DEGVSGEE-VFAEHGGQARG----HRGHGSEDTEDSAEHRHHLPSHRSHSHQDEDEDEVV 169
D G GE+ V +H G G H + + D ED HH+ + S DE +
Sbjct: 24 DSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGLPKGHHV----TDSENDEPLNLNA 79
Query: 170 SSEHHHHILRHGHRGHDGEDDEGEE----EEEEEEEEEEASTEYGHQAHRHRGHGSEEDE 225
S + H + D E +E E + E E+ + S + + G S E+E
Sbjct: 80 SDSESEEL--HRQKDSDSESEERAEPPASDSENEDVNQHGSDSESEETRKLPGSDS-ENE 136
Query: 226 DVSDGHHHHGPSHRHQGHEEDDDD---------DDDDDDDDDDDDVSIEYRHQAHRHQGH 276
++ +GH + H D + D + +D +S + RHQ
Sbjct: 137 ELLNGHASDSENEDVGKHPASDSEIEELQKSPASDSETEDALKPQISDSESEEPPRHQ-- 194
Query: 277 GIEEDEDVSDGHHHRDPSHRHRSHEEDDNDDDDVSTEYGHQAHRHQ--DHRKEEVEAVSG 334
SD + P R E ++ VS + RHQ D EE+
Sbjct: 195 -------ASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEELPKPRI 247
Query: 335 EHHHHVPDHRHQGHRDEEEDEDVSTERWHQGPQHVHHGLVDEEEEEEEITVQFGHYVASH 394
RHQ + E+E++ R + + E E+ Q
Sbjct: 248 SDSESEDPPRHQA--SDSENEELPKPR------------ISDSESEDPPRNQASDSENEE 293
Query: 395 QPRGHKSDEEDFQDEYKTEVPHHHHHRVPREEDEEVSAELGHQAPSHRQSHQDEETGHGQ 454
P+ SD E +E P + P + E A Q P D+++
Sbjct: 294 LPKPRVSDSE-------SEGP----QKGPASDSETEDASRHKQKP-----ESDDDSDREN 337
Query: 455 RGSIKEM---SHHPPGHTVVKDRSHLRKDDSEEEKEKEEDPGSHEEDDESSEQGEKGTHH 511
+G EM S H H DR DSEEE+ K++ S E++ E E EK
Sbjct: 338 KGEDTEMQNDSFHSDSH---MDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEE--EKVAKR 392
Query: 512 GSRDQEDEEDEEEGHGLSLNQEEEEEEDKEEEEEEEDEERREE------RAEVGAPLSPD 565
+ D EDEE+ ++ + +D + + + +RE+ E G LS
Sbjct: 393 KAAVLSDSEDEEKA-SAKKSRVVSDADDSDSDAVSDKSGKREKTIASDSEEEAGKELSDK 451
Query: 566 HSEEEE----EEEEGLEEDEPRFTIIPNPLDRREEAGGASSEEESGEDTGPQDAQE 617
+EE++ + E G EE+ I D EE ++E+ E+ G +E
Sbjct: 452 KNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEEEKGETQVKE 507
Score = 86.7 bits (213), Expect = 7e-17
Identities = 112/524 (21%), Positives = 191/524 (36%), Gaps = 64/524 (12%)
Query: 69 DENKDVSTENGHHFWSHPDREKEDEDVSKEYGHLLPGHRSQDHKVGDEGVSGEEVFAEHG 128
D DV+ ++ +R E+E +E G L GH D + +E +
Sbjct: 28 DGEDDVNEQHSGSDTGSVERHSENETSDREDG-LPKGHHVTDSE-------NDEPLNLNA 79
Query: 129 GQARGHRGHGSEDTEDSAEHRHHLPSHRS-------HSHQDEDED--EVVSSEHHHHILR 179
+ H +D++ +E R P+ S H E E+ ++ S+ + L
Sbjct: 80 SDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSESEETRKLPGSDSENEELL 139
Query: 180 HGHRGHDGEDDEGEEEEEEEEEEEEASTEYGHQAHRHRGHGSEEDE----DVSDGHHHHG 235
+GH +D G+ + E EE + SE ++ +SD
Sbjct: 140 NGHASDSENEDVGKHPASDSEIEE---------LQKSPASDSETEDALKPQISDSESEEP 190
Query: 236 PSHRHQGHEEDDDDDDDDDDDDDDD----DVSIEYRHQAHRHQGHGIEEDE----DVSDG 287
P H+ E ++ D + ++ VS + RHQ E +E +SD
Sbjct: 191 PRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEELPKPRISDS 250
Query: 288 HHHRDPSHRHRSHEEDDNDDDDVSTEYGHQAHRHQDHRKEEVEAVSGEHHHHVPDHRHQG 347
P H+ E ++ +S R+Q E E + +G
Sbjct: 251 ESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQKG 310
Query: 348 HRDEEEDEDVSTERWHQGPQHVHHGLVDEEEEEEEITVQFGHYVA-SHQPRG--HKSDEE 404
+ E ED S R Q P+ D E + E+ +Q + + SH R H SD E
Sbjct: 311 PASDSETEDAS--RHKQKPESDDDS--DRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSE 366
Query: 405 DFQDEYKTEVPHHHHHRVPREEDEEVSAE--LGHQAPSHRQSHQDEETGHGQRGSIKEMS 462
+ + H ++ +EDE+ E + + + +DEE ++ + +
Sbjct: 367 EEE---------HKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDA 417
Query: 463 HHPPGHTVVKDRSHLRK----DDSEEEKEKEEDPGSHEEDDESSEQGEKGTHHGSRDQE- 517
V D+S R+ DSEEE KE +EE D E G + +
Sbjct: 418 DDSDSDAV-SDKSGKREKTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLIADI 476
Query: 518 --DEEDEEEGHGLSLNQEEEEEEDKEEEEEEEDEERREERAEVG 559
+ DEEE NQE+ EEE E + +E ++ ++ + G
Sbjct: 477 FGESGDEEEEEFTGFNQEDLEEEKGETQVKEAEDSDSDDNIKRG 520
Score = 79.3 bits (194), Expect = 1e-14
Identities = 94/456 (20%), Positives = 167/456 (36%), Gaps = 78/456 (17%)
Query: 237 SHRHQGHEEDDD-----DDDDDDDDDDDDDVSIEYRHQ----AHRHQGHGIEEDED-VSD 286
S + G + DD D+ D D +DDV+ ++ RH + + ED +
Sbjct: 3 SEYYSGDQSDDGGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGLPK 62
Query: 287 GHHHRDP------------SHRHRSHEEDDNDDDD-------VSTEYGHQAHRH-QDHRK 326
GHH D S H + D+D + S ++H D
Sbjct: 63 GHHVTDSENDEPLNLNASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSES 122
Query: 327 EEVEAVSGEHHHHVPDHRHQGHRDEEEDEDVSTERWHQGP-QHVHHGLVDEEEEEEEITV 385
EE + G + + GH + E+EDV + + + E E+ +
Sbjct: 123 EETRKLPGSDSEN--EELLNGHASDSENEDVGKHPASDSEIEELQKSPASDSETEDALKP 180
Query: 386 QFGHYVASHQPRGHKSDEED-------FQDEYKTEVPHHH----------HHRVPREEDE 428
Q + PR SD E+ D E+P H+ E+E
Sbjct: 181 QISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENE 240
Query: 429 E-----VSAELGHQAPSHRQSHQDEETGHGQRGSIKEMSHHPPGHTVVKDRSHLRK---D 480
E +S P H+ S + E R S E P + L K
Sbjct: 241 ELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVS 300
Query: 481 DSEEEKEKEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEE------ 534
DSE E ++ P S E +++S +K D+E++ ++ E S + +
Sbjct: 301 DSESEGP-QKGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKK 359
Query: 535 ------EEEEDKEEEEEEEDEERREERAEVGAPLSPDHSEEEEEEEEGLEE-------DE 581
EEEE K+++ + +++E+ E +V + S+ E+EE+ ++ D+
Sbjct: 360 FHSSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADD 419
Query: 582 PRFTIIPNPLDRREEAGGASSEEESGEDTGPQDAQE 617
+ + +RE+ + SEEE+G++ + +E
Sbjct: 420 SDSDAVSDKSGKREKTIASDSEEEAGKELSDKKNEE 455
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 83.6 bits (205), Expect = 6e-16
Identities = 89/472 (18%), Positives = 159/472 (33%), Gaps = 38/472 (8%)
Query: 135 RGHGSEDTEDSAEHRHHLPSHRSHSHQDEDEDEVVSSEHHHHILRHGHRGHDGEDDEGEE 194
+ H D +D +R R Q E E + E RH R E E
Sbjct: 44 QAHKDADGDDRERNRQKERERRREKRQTERETDR-KRERRREKDRHRKRDRHRERQRDRE 102
Query: 195 EEEEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEEDDDDDDDDD 254
+E E + + E + + +R + E + + G R + + D + + +
Sbjct: 103 KERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQ 162
Query: 255 DDDDDDDVSIEYRHQAHRHQGHGIE--EDEDVSDGHHHRDPSHRHRSHEEDDNDDDDVST 312
D + + R + + + E E E + + + H R E + + + T
Sbjct: 163 TDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETET 222
Query: 313 EYGHQAHRHQD-HRKEEVEAVSGEHHHHVPDHRHQGHRDEEEDEDVSTERWHQGPQHVHH 371
E Q R +D RK E E + + ++ E + D +R
Sbjct: 223 ERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDR---------- 272
Query: 372 GLVDEEEEEEEITVQFGHYVASHQPRGHKSDEEDFQDEYKTEVPHHHHHRVPREEDEEVS 431
D ++E E Q R + E + + E + E RE + E
Sbjct: 273 ---DRRQKERERQTD-----RKRQRRTERDRETERKRERQRERERERERNRKRERERERE 324
Query: 432 AELGHQAPSHRQSHQDEETGHGQRGSIKEMSHHPPGHTVVKDRSHLRKDDSEEEKEKEED 491
E Q + R ++ E ++ + + G R R+ + E E+E+E D
Sbjct: 325 RERERQRETERDREKERERKRKRQTEMDRERNRQTG------REGRRQAERERERERERD 378
Query: 492 PGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEEEDKEEEEEEEDEER 551
S E +E ++ R +E E E+ E++ E +K+ E E E
Sbjct: 379 RQSAREREERERDRDR-----DRQKERERQTEKDRDGQRETEKQREREKDRESERGRERG 433
Query: 552 REERAEVGAPLSPDHSEEEEEEEEGLEEDEPRFTIIPNPLDRREEAGGASSE 603
RE + G + E + + R T+ NP R +G S+
Sbjct: 434 REREKQKGR-----ERDRERQTDRQAGRQRKRSTLYVNPPPRTARSGVVQSD 480
Score = 81.6 bits (200), Expect = 2e-15
Identities = 87/460 (18%), Positives = 159/460 (34%), Gaps = 59/460 (12%)
Query: 178 LRHGHRGHDGEDDEGEEEEEEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPS 237
L H+ DG+D E ++E E E+ TE + R R E+D H
Sbjct: 42 LGQAHKDADGDDRERNRQKERERRREKRQTE--RETDRKRERRREKDR--------HRKR 91
Query: 238 HRHQGHEEDDDDDDDDDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDGHHHRDPSHRH 297
RH+ + D + + + D + D + + +R + E + + G + R
Sbjct: 92 DRHRERQRDREKERERQTDRERDR---QREKERNRQKERERETEREGERGRDRQTDGQRE 148
Query: 298 RSHEEDDNDDDDVSTEYGHQAHRHQDHRKEEVEAVSGEHHHHVPDHRHQGHRDEEEDEDV 357
R + D + + T+ Q ++ +KE + + + R+ + +++
Sbjct: 149 RERQRDAEKERERQTDRERQRQTERNRQKER---------EREKNRQERRERERQREKEN 199
Query: 358 STERWHQGPQHVHHGLVDEEEEEEEITVQFGHYVASHQPRGHKSDEEDFQDEYKTEVPHH 417
TE +H G E E E E + + R K++ E
Sbjct: 200 KTE-----DRHSERGRERERERETETETERKRQTDRERDRQRKTERE------------- 241
Query: 418 HHHRVPREEDEEVSAELGHQAPSHRQSHQDEETGHGQRGSIKEMSHHPPGHTVVKDRSHL 477
+ RE E E + R +D + +R + + +DR
Sbjct: 242 REKQAERERASERETERDKERERERDRDRDRDRRQKER---ERQTDRKRQRRTERDRETE 298
Query: 478 RKDDSEEEKEKEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEE 537
RK + + E+E+E + E + E+ + RD+E E + + +++E +
Sbjct: 299 RKRERQRERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRERNRQ 358
Query: 538 EDKE---------EEEEEEDEERREERAEVGAPLSPDHSEEEEEEEE----GLEEDEPRF 584
+E E E E D + ER E D +E E + E G E E +
Sbjct: 359 TGREGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQ- 417
Query: 585 TIIPNPLDRREEAGGASSEEESGEDTGPQDAQEYGNYQPG 624
DR E G E + +D + + Q G
Sbjct: 418 --REREKDRESERGRERGREREKQKGRERDRERQTDRQAG 455
Score = 35.0 bits (79), Expect = 0.24
Identities = 29/132 (21%), Positives = 49/132 (37%), Gaps = 28/132 (21%)
Query: 478 RKDDSEE-----------------------EKEKE---EDPGSHEEDDESSEQGEKGTHH 511
R+ S+E +KE+E E + E D E+ + H
Sbjct: 29 RRPGSQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRH 88
Query: 512 GSRD--QEDEEDEEEGHGLSLNQEEEEEEDKEEEEEEEDEERREERAEVGAPLSPDHSEE 569
RD +E + D E+ ++E + + +KE ++E E E E G D E
Sbjct: 89 RKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRE 148
Query: 570 EEEEEEGLEEDE 581
E + + +E E
Sbjct: 149 RERQRDAEKERE 160
Score = 32.0 bits (71), Expect = 2.0
Identities = 48/281 (17%), Positives = 86/281 (30%), Gaps = 14/281 (4%)
Query: 52 EASAELRHHLHSPRDHPDENKDVSTENGHHFWSHPDREKEDE---DVSKEYGHLLPGHRS 108
E + + R R+ ++ +D +E G + E E E +E R
Sbjct: 182 EKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTERE 241
Query: 109 QDHKVGDEGVSGEEVFAEHGGQA-------RGHRGHGSEDTEDSAEHRHHLPSHRSHSHQ 161
++ + E S E + + R R E D R + +
Sbjct: 242 REKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKR 301
Query: 162 DEDEDEVVSSEHHHHILRHGHRGHDGEDDEGEEEEEEEEEEEEASTEYGHQAHRHRGHGS 221
+ + E + R R + E E + E+E E + + R+R G
Sbjct: 302 ERQRERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRERNRQTGR 361
Query: 222 EEDEDVSDGHHHHGPSHRHQGHEEDDDDDDDDDDDDDDDDVSIEYRHQAHRHQGHGIEED 281
E R E ++ + D D D + + E R E +
Sbjct: 362 EGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQRERE 421
Query: 282 EDVSDGHHHRDPSHRHRSHEEDDNDDDDVSTEYGHQAHRHQ 322
+D + R+ R R E+ + D + QA R +
Sbjct: 422 KD-RESERGRE---RGREREKQKGRERDRERQTDRQAGRQR 458
>gi|62122917 filaggrin family member 2 [Homo sapiens]
Length = 2391
Score = 81.6 bits (200), Expect = 2e-15
Identities = 112/533 (21%), Positives = 156/533 (29%), Gaps = 92/533 (17%)
Query: 117 GVSGEEVFAEHGGQARGHRGHGSEDTEDSAEHR--HHLPS--HRSHSHQDEDEDEVVSSE 172
G SG + G + G RG G ++ DS H H P ++H E S+
Sbjct: 1402 GHSGHGQSTQRGSRTTGRRGSGHSESSDSEVHSGGSHRPQSQEQTHGQAGSQHGESGSTV 1461
Query: 173 HHHHILRHGHRG--------HDGEDDE---------GEEEEEEEEEEEEASTEYGHQAHR 215
H H HG G H G+ + G E + E + + H H
Sbjct: 1462 HGRHGTTHGQTGDTTRHAHYHHGKSTQRGSSTTGRRGSGHSESSDSEVHSGGSHTHSGHT 1521
Query: 216 HRGHGSEEDEDVSDGHHHHGPSHRHQGHEEDDDDDDDDDDDDDDDDVSIEYRHQAHRHQG 275
H GS+ E S H H +H G D + R +
Sbjct: 1522 HGQSGSQHGESESIIHDRHRITHGQTG------DTTRHSYSGHEQTTQTGSRTTGRQRTS 1575
Query: 276 HGIEEDEDVSDGHHHRDPSHRH------RSHEEDD-NDDDDVSTEYGH----QAHRHQDH 324
H D +V G HR S H HEE + + T +G H H H
Sbjct: 1576 HSESTDSEVHSGGSHRPHSREHTYGQAGSQHEEPEFTVHERHGTTHGQIGDTTGHSHSGH 1635
Query: 325 --------------RKEEVEAVSGEHHHHVPDHRHQGHRDEE------EDEDVSTERW-- 362
R E+ E H V H H GH + + E + ER
Sbjct: 1636 GQSTQRGSRTTGRQRSSHSESSDSEVHSGV-SHTHTGHTHGQAGSQHGQSESIVPERHGT 1694
Query: 363 -------HQGPQHVHHGLVDEE---------EEEEEITVQFGHYVASHQPRGHKSDEEDF 406
H HHGL + E + G+ SH GH +
Sbjct: 1695 THGQTGDTTRHAHYHHGLTTQTGSRTTGRRGSGHSEYSDSEGYSGVSHTHSGHTHGQARS 1754
Query: 407 QDEYKTEVPHHHHHRVPREEDEEVSAELGHQAPSHRQSHQDEETGHGQRGSIKEMSHHPP 466
Q + H H + + + H H QS Q G+R S
Sbjct: 1755 QHGESESIVHERHGTIHGQTGDTTR----HAHSGHGQSTQTGSRTTGRRSSGHSEYSDSE 1810
Query: 467 GHTVVKDRSHLRKDDSEEEKEKEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGH 526
GH+ R H R GS + ES GT HG + + + GH
Sbjct: 1811 GHSGFSQRPHSR-------GHTHGQAGSQHGESESIVDERHGTTHG-QTGDTSGHSQSGH 1862
Query: 527 GLSLNQEEEEEEDKEEEEEEEDEERREERAEVGAPLSPDHSEEEEEEEEGLEE 579
G S + E + E G+ H+ + + G E
Sbjct: 1863 GQSTQSGSSTTGRRRSGHSESSD---SEVHSGGSHTHSGHTHSQARSQHGESE 1912
Score = 79.7 bits (195), Expect = 8e-15
Identities = 114/508 (22%), Positives = 150/508 (29%), Gaps = 101/508 (19%)
Query: 32 GDGLGFRNRNNSTG--VAGLSEEASAELRHHLHSPRDHPDENKDVSTENGHHFWSHPDRE 89
G G + + +TG +G SE + +E H S R H GH +
Sbjct: 1784 GHGQSTQTGSRTTGRRSSGHSEYSDSE-GHSGFSQRPH---------SRGHTHGQAGSQH 1833
Query: 90 KEDEDVSKEYGHLLPGHR--SQDHKVGDEGVSGEEVFAEHGGQARGHRGHGSEDTEDSAE 147
E E + E G + H G S + + G + GH +
Sbjct: 1834 GESESIVDERHGTTHGQTGDTSGHSQSGHGQSTQSGSSTTGRRRSGHSESSDSEVHSGGS 1893
Query: 148 HRHHLPSHRSHSHQDEDEDEVVSSEHHHHILRHGHRGHDGEDD----------------- 190
H H S +HS E S+ H H HG G E
Sbjct: 1894 HTH---SGHTHSQARSQHGESESTVHKRHQTTHGQTGDTTEHGHPSHGQTIQTGSRTTGR 1950
Query: 191 EGEEEEEEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEEDDDDD 250
G E + E + + H H H GS E S H HG +H G D
Sbjct: 1951 RGSGHSEYSDSEGPSGVSHTHSGHTHGQAGSHYPESGSSVHERHGTTH---GQTADT--- 2004
Query: 251 DDDDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSHEEDDNDDDDV 310
H H GHG S R R H E + +
Sbjct: 2005 ------------------TRHGHSGHG------QSTQRGSRTTGRRASGHSEYSDSEGHS 2040
Query: 311 STEYGHQAHRHQDHRKEEVEAVSGEHHHHVPDHRHQGHRDEEEDEDVSTERWHQGPQHVH 370
+ H H H + E+ S H H H G +T H G
Sbjct: 2041 GVSHTHSGHAHGQAGSQHGESGSSVHERHGTTHGQTGD---------TTRHAHSG----- 2086
Query: 371 HGLVDEEEEEEEITVQFGHYVASHQPRGHKSDEEDFQDEYKTEVPH----HHHHRVPREE 426
HG + Q G A + GH E E + V H H + + +
Sbjct: 2087 HGQ----------STQRGSRTAGRRGSGH---SESSDSEVHSGVSHTHSGHTYGQARSQH 2133
Query: 427 DEEVSAELGHQAPSHRQSHQDEETGHGQRGSIKEMSHHPPGHTVVKDR-SHLRKDDSEEE 485
E SA G Q H Q+ + T HGQ G S T + R SH DSE
Sbjct: 2134 GESGSAIHGRQGTIHGQT--GDTTRHGQSG--HGQSTQTGSRTTGRQRSSHSESSDSEVH 2189
Query: 486 KEKEEDPGSHEEDDESSEQGEKGTH-HG 512
E H S G+ G+ HG
Sbjct: 2190 SEASPTHSGHTHSQAGSRHGQSGSSGHG 2217
Score = 78.6 bits (192), Expect = 2e-14
Identities = 114/543 (20%), Positives = 162/543 (29%), Gaps = 107/543 (19%)
Query: 32 GDGLGFRNRNNSTGV--AGLSEEASAELRH---HLHSPRDHPDENKDVSTENGHHFWSHP 86
G G ++ +++TG +G SE + +E+ H HS H H
Sbjct: 1861 GHGQSTQSGSSTTGRRRSGHSESSDSEVHSGGSHTHSGHTHSQARSQHGESESTVHKRHQ 1920
Query: 87 DREKEDEDVSKEYGHLLPGHRSQDHKVGDEGVSGEEVFAEHGGQARGHRGHGSEDTEDSA 146
+ D + E+GH P H G+ + + G + G RG G + DS
Sbjct: 1921 TTHGQTGDTT-EHGH--PSH-------------GQTI--QTGSRTTGRRGSGHSEYSDSE 1962
Query: 147 EHRHHLPSHRSHSHQDEDED--EVVSSEHHHH---------ILRHGHRGHDGEDDEGEE- 194
+H H+H E SS H H RHGH GH G
Sbjct: 1963 GPSGVSHTHSGHTHGQAGSHYPESGSSVHERHGTTHGQTADTTRHGHSGHGQSTQRGSRT 2022
Query: 195 -------EEEEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEEDD 247
E + E + + H H H GS+ E S H HG +H G
Sbjct: 2023 TGRRASGHSEYSDSEGHSGVSHTHSGHAHGQAGSQHGESGSSVHERHGTTHGQTGDT--- 2079
Query: 248 DDDDDDDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSHEEDDNDD 307
H H GHG S R R H E + +
Sbjct: 2080 ---------------------TRHAHSGHG------QSTQRGSRTAGRRGSGHSESSDSE 2112
Query: 308 DDVSTEYGHQAHRHQDHRKEEVEAVSGEHHHHVPDHRHQG----HRDEEEDEDVSTERWH 363
+ H H + R + E+ S H H G H + T
Sbjct: 2113 VHSGVSHTHSGHTYGQARSQHGESGSAIHGRQGTIHGQTGDTTRHGQSGHGQSTQTGSRT 2172
Query: 364 QGPQHVHHG-LVDEEEEEEEITVQFGHYVASHQPRGHKSDEEDFQDEYKTEVPH------ 416
G Q H D E E GH +H G + + + H
Sbjct: 2173 TGRQRSSHSESSDSEVHSEASPTHSGH---THSQAGSRHGQSGSSGHGRQGTTHGQTGDT 2229
Query: 417 -HHHHRVPREEDEEVSAELGHQAPSHRQSHQDEETGHGQRGSIKEMSHHPPGHTVVKDRS 475
H H + + S G + H +S E G SH GH + S
Sbjct: 2230 TRHAHYGYGQSTQRGSRTTGRRGSGHSESSDSEVHSWG--------SHTHSGHIQGQAGS 2281
Query: 476 HLRKDDSEEEKEKEEDPGSHEEDDESSEQGEKG----THHGSRDQ-----EDEEDEEEGH 526
R+ S E +H + +++ G G T GSR + E + H
Sbjct: 2282 QQRQPGSTVHGRLET---THGQTGDTTRHGHSGYGQSTQTGSRSSRASHFQSHSSERQRH 2338
Query: 527 GLS 529
G S
Sbjct: 2339 GSS 2341
Score = 76.3 bits (186), Expect = 9e-14
Identities = 126/609 (20%), Positives = 167/609 (27%), Gaps = 115/609 (18%)
Query: 67 HPDENKDVSTENGHHFWSHPDREKEDEDVSKEYGHLLPGHRSQDH---KVGDEGVSGEEV 123
H + ST+ G + R + E+ E H HR +H + G
Sbjct: 1249 HSQSGQGQSTQTGSRV-TRRRRSSQSENSDSEV-HSKVSHRHSEHIHTQAGSHYPKSGST 1306
Query: 124 FAEHGGQARGHRG----HGSEDTEDSAEHRHHLPSHRSHSHQDEDEDEVVSS-EHHHHIL 178
G G RG HG S + + SH D + EV S H H
Sbjct: 1307 VRRRQGTTHGQRGDTTRHGHSGHGQSTQTGSRTSGRQRFSHSDATDSEVHSGVSHRPHSQ 1366
Query: 179 RHGHRGHDGEDDEGEEEEEEEEEEEEASTEYGHQA----HRHRGHGSEED---------- 224
H + E E E E T YG H H GHG
Sbjct: 1367 EQTHSQAGSQHGESESTVHERHE-----TTYGQTGEATGHGHSGHGQSTQRGSRTTGRRG 1421
Query: 225 ---EDVSDGHHHHGPSHRHQGHEEDDDDDDDDDDDDDDDDVSIEYRHQAHRHQGHGIEED 281
+ SD H G SHR Q E+ + ++ RH HG D
Sbjct: 1422 SGHSESSDSEVHSGGSHRPQSQEQTHGQAGSQHGESGS---TVHGRHGT----THGQTGD 1474
Query: 282 EDVSDGHHHRDPSHRHRS--------HEEDDNDDDDVSTEYGHQAHRHQDHRKEEVEAVS 333
+HH + R S H E + + + H H H + E+ S
Sbjct: 1475 TTRHAHYHHGKSTQRGSSTTGRRGSGHSESSDSEVHSGGSHTHSGHTHGQSGSQHGESES 1534
Query: 334 GEHHHH---------VPDHRHQGHRDEEEDEDVSTERW------------HQGPQHVHH- 371
H H H + GH + +T R H G H H
Sbjct: 1535 IIHDRHRITHGQTGDTTRHSYSGHEQTTQTGSRTTGRQRTSHSESTDSEVHSGGSHRPHS 1594
Query: 372 -----GLVDEEEEEEEITVQFGHYVASHQ---PRGHKSDEEDFQDEYKTEVPHHHHHRVP 423
G + EE E TV H Q GH + +
Sbjct: 1595 REHTYGQAGSQHEEPEFTVHERHGTTHGQIGDTTGHSHSGHGQSTQRGSRTTGRQRSSHS 1654
Query: 424 REEDEEVSAELGHQAPSH------RQSHQDEE-------TGHGQRGSIKEMSHHPPGHTV 470
D EV + + H H Q Q E T HGQ G +H+ G T
Sbjct: 1655 ESSDSEVHSGVSHTHTGHTHGQAGSQHGQSESIVPERHGTTHGQTGDTTRHAHYHHGLTT 1714
Query: 471 V--------KDRSHLRKDDSEEEKEKEEDPGSHEEDDESSEQGEK--------GTHHGSR 514
+ H DSE H S+ GE GT HG +
Sbjct: 1715 QTGSRTTGRRGSGHSEYSDSEGYSGVSHTHSGHTHGQARSQHGESESIVHERHGTIHG-Q 1773
Query: 515 DQEDEEDEEEGHGLSL--------NQEEEEEEDKEEEEEEEDEERREERAEVGAPLSPDH 566
+ GHG S + E + E +R R H
Sbjct: 1774 TGDTTRHAHSGHGQSTQTGSRTTGRRSSGHSEYSDSEGHSGFSQRPHSRGHTHGQAGSQH 1833
Query: 567 SEEEEEEEE 575
E E +E
Sbjct: 1834 GESESIVDE 1842
Score = 72.4 bits (176), Expect = 1e-12
Identities = 104/561 (18%), Positives = 164/561 (29%), Gaps = 83/561 (14%)
Query: 111 HKVGDEGVSGEEVFAEHGGQARGHRGHGSEDTEDSAEHRHHLPSHRSHSHQDEDEDEVVS 170
H+ G SG + GQ+ G HGS + S +H S +S S+ S
Sbjct: 1105 HRPGSGQSSGFGQYGSGSGQSSGFGQHGSGTGKSSGFAQHEYRSGQS-SYGQHGTGSSQS 1163
Query: 171 SEHHHHILRHGHRGHDGEDDEGEE------EEEEEEEEEEASTEYGHQAHRHRGHGSEED 224
S H G G+ G + + + + +YG + + G G E
Sbjct: 1164 SGCGQHESGSGPTTSFGQHVSGSDNFSSSGQHISDSGQSTGFGQYGSGSGQSTGLGQGES 1223
Query: 225 EDVSDGHHHHGPSHRHQG-------HEEDDDDDD--------------DDDDDDDDDDVS 263
+ V G HG G H + ++ D +
Sbjct: 1224 QQVESGSTVHGRQETTHGQTINTTRHSQSGQGQSTQTGSRVTRRRRSSQSENSDSEVHSK 1283
Query: 264 IEYRHQAHRH---------QGHGIEEDEDVSDGHHHRDPSHRHRSHEEDDN--------- 305
+ +RH H H G + + + G H H H +
Sbjct: 1284 VSHRHSEHIHTQAGSHYPKSGSTVRRRQGTTHGQRGDTTRHGHSGHGQSTQTGSRTSGRQ 1343
Query: 306 --DDDDVSTEYGHQAHRHQDHRKEEVEAVSGEHHHHVPDHRHQGHRDEEEDEDVSTERWH 363
D + H H+ H +E+ + +G H H+ H +T H
Sbjct: 1344 RFSHSDATDSEVHSGVSHRPHSQEQTHSQAGSQHGESESTVHERHETTYGQTGEATGHGH 1403
Query: 364 QGPQHVHHGLVDEEEEEEEITVQFGHYVASHQPRGHKSDEEDFQDEYKTEVPHHHHHRVP 423
G HG + Q G + GH + +EV HR
Sbjct: 1404 SG-----HGQ----------STQRGSRTTGRRGSGHSESSD-------SEVHSGGSHRPQ 1441
Query: 424 REEDEEVSAELGHQAPSHRQSHQDEETGHGQRGSIKEMSHHPPGHTVVKDRS-------- 475
+E A H S H T HGQ G +H+ G + + S
Sbjct: 1442 SQEQTHGQAGSQH-GESGSTVHGRHGTTHGQTGDTTRHAHYHHGKSTQRGSSTTGRRGSG 1500
Query: 476 HLRKDDSEEEKEKEEDPGSHEEDDESSEQGEKGT--HHGSRDQEDEEDEEEGHGLSLNQE 533
H DSE H S+ GE + H R + + H S +++
Sbjct: 1501 HSESSDSEVHSGGSHTHSGHTHGQSGSQHGESESIIHDRHRITHGQTGDTTRHSYSGHEQ 1560
Query: 534 EEEEEDKEE-EEEEEDEERREERAEVGAPLSPDHSEEEEEEEEGLEEDEPRFTIIPNPLD 592
+ + + E + G P HS E + G + +EP FT+
Sbjct: 1561 TTQTGSRTTGRQRTSHSESTDSEVHSGGSHRP-HSREHTYGQAGSQHEEPEFTVHERHGT 1619
Query: 593 RREEAGGASSEEESGEDTGPQ 613
+ G + SG Q
Sbjct: 1620 THGQIGDTTGHSHSGHGQSTQ 1640
Score = 42.0 bits (97), Expect = 0.002
Identities = 29/123 (23%), Positives = 43/123 (34%), Gaps = 11/123 (8%)
Query: 126 EHGGQARGHRGHGSEDTEDSAEHRHHLPSHRSHSH-QDEDEDEVVSSEHHHHI------- 177
+ G + G RG G ++ DS H +H H Q + S H +
Sbjct: 2242 QRGSRTTGRRGSGHSESSDSEVHSWGSHTHSGHIQGQAGSQQRQPGSTVHGRLETTHGQT 2301
Query: 178 ---LRHGHRGHDGEDDEGEEEEEEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHH 234
RHGH G+ G + +S H + + HGS + GH +
Sbjct: 2302 GDTTRHGHSGYGQSTQTGSRSSRASHFQSHSSERQRHGSSQVWKHGSYGPAEYDYGHTGY 2361
Query: 235 GPS 237
GPS
Sbjct: 2362 GPS 2364
Score = 36.6 bits (83), Expect = 0.081
Identities = 24/112 (21%), Positives = 40/112 (35%), Gaps = 10/112 (8%)
Query: 228 SDGHHHHGPSHRHQGHEEDDDDDDDDDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDG 287
+ G H HRHQ E + ++D++D +RH E+ S G
Sbjct: 96 ASGSKKHRRGHRHQEEESETEEDEEDTPG----------HKSGYRHSSWSEGEEHGYSSG 145
Query: 288 HHHRDPSHRHRSHEEDDNDDDDVSTEYGHQAHRHQDHRKEEVEAVSGEHHHH 339
H RH S+ ++S+ + + + HR + SG H
Sbjct: 146 HSRGTVKCRHGSNSRRLGRQGNLSSSGNQEGSQKRYHRSSCGHSWSGGKDRH 197
Score = 36.6 bits (83), Expect = 0.081
Identities = 32/129 (24%), Positives = 44/129 (34%), Gaps = 9/129 (6%)
Query: 116 EGVSGEEVFAEHG---GQARGHRGHGSEDTEDSAEHRHHLPSHRSHSHQDEDEDEVVSSE 172
E SG + +HG Q+ G+ HGS + S +H L S +S S SS
Sbjct: 685 ESRSGHSSYGQHGFGSSQSSGYGQHGSSSGQTSGFGQHELSSGQSSSFGQHGSGSGQSSG 744
Query: 173 HHHHILRHGHRGHDG--EDDEGEEEEEEEEEEEEASTEYGHQAHRHRG----HGSEEDED 226
H G G E G+ + S+ YG R HGS +
Sbjct: 745 FGQHGSGSGQSSGFGQHESRSGQSSYGQHSSGSSQSSGYGQHGSRQTSGFGQHGSGSSQS 804
Query: 227 VSDGHHHHG 235
G + G
Sbjct: 805 TGFGQYGSG 813
Score = 36.2 bits (82), Expect = 0.11
Identities = 40/180 (22%), Positives = 68/180 (37%), Gaps = 16/180 (8%)
Query: 474 RSHLRKDDSEEEKEKEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQE 533
R H +++ E +E EED H+ S E G HG + HG S ++
Sbjct: 104 RGHRHQEEESETEEDEEDTPGHKSGYRHSSWSE-GEEHGYSSGHSRGTVKCRHG-SNSRR 161
Query: 534 EEEEEDKEEEEEEEDEERREERAEVGAPLSPDHSEEEEEEEEGLEEDEPRFTIIPNPLDR 593
+ + +E ++R R+ G HS ++ G E R I + +
Sbjct: 162 LGRQGNLSSSGNQEGSQKRYHRSSCG------HSWSGGKDRHGSSSVELRERINKSHISP 215
Query: 594 REEAGGASSEEESGEDTGPQDAQEYGNYQPGSLCGYCSFCNRCTECESCHCDEENMGEHC 653
E+G E ESG + + + +G G CG + + +S E+ +G C
Sbjct: 216 SRESG---EEYESGSGSNSWERKGHG----GLSCGLETSGHESNSTQS-RIREQKLGSSC 267
Score = 34.7 bits (78), Expect = 0.31
Identities = 22/72 (30%), Positives = 28/72 (38%), Gaps = 15/72 (20%)
Query: 179 RHGHRGHDGEDDEGEEEEEEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHH------ 232
R GHR +EEE E EE+E T +RH E+ S GH
Sbjct: 103 RRGHR---------HQEEESETEEDEEDTPGHKSGYRHSSWSEGEEHGYSSGHSRGTVKC 153
Query: 233 HHGPSHRHQGHE 244
HG + R G +
Sbjct: 154 RHGSNSRRLGRQ 165
Score = 32.0 bits (71), Expect = 2.0
Identities = 38/165 (23%), Positives = 54/165 (32%), Gaps = 27/165 (16%)
Query: 88 REKEDEDVSKEYGHLLPGHRS-QDHKVGDEGVSGEEVFAEHGGQARGHRGHGSEDTEDSA 146
R +E+E ++E PGH+S H EG E G + GH + S
Sbjct: 107 RHQEEESETEEDEEDTPGHKSGYRHSSWSEG--------EEHGYSSGHSRGTVKCRHGSN 158
Query: 147 EHRHHLPSHRSHSHQDEDEDEVVSSEHHHHILRHGHRGHDGEDDEGEEEEE--------- 197
R + S S E S+ +H GH G+D G E
Sbjct: 159 SRRLGRQGNLSSSGNQE------GSQKRYHRSSCGHSWSGGKDRHGSSSVELRERINKSH 212
Query: 198 ---EEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHR 239
E EE + G + +GHG + GH + R
Sbjct: 213 ISPSRESGEEYESGSGSNSWERKGHGGLSCGLETSGHESNSTQSR 257
Score = 31.6 bits (70), Expect = 2.6
Identities = 29/132 (21%), Positives = 46/132 (34%), Gaps = 9/132 (6%)
Query: 111 HKVGDEGVSGEEVFAEHGGQARGHRGHGSEDTEDSAEHRHHLPSHRSHSHQDEDEDEVVS 170
H G +G + GQ+ G HGS + S +H SH+S S+ S
Sbjct: 797 HGSGSSQSTGFGQYGSGSGQSAGFGQHGSGSGQSSGFGQHESRSHQS-SYGQHGSGSSQS 855
Query: 171 SEHHHHILRHG-------HRGHDGEDDEGEEEEEEEEEEEEASTEYGHQAHRHRGHGSEE 223
S + H G HR G+ G + + ++G + ++ G G E
Sbjct: 856 SGYGQHGSSSGQTSGFGQHRSSSGQ-YSGFGQHGSGSGQSSGFGQHGTGSGQYSGFGQHE 914
Query: 224 DEDVSDGHHHHG 235
+ HG
Sbjct: 915 SRSHQSSYGQHG 926
Score = 30.4 bits (67), Expect = 5.8
Identities = 19/79 (24%), Positives = 33/79 (41%), Gaps = 10/79 (12%)
Query: 295 HRHRSHEEDDNDDDDVSTEYGHQAHRHQDHRKEEVEAVSGEHHHHVPDHRH--------- 345
HRH+ EE + ++D+ T +RH + E S H RH
Sbjct: 106 HRHQE-EESETEEDEEDTPGHKSGYRHSSWSEGEEHGYSSGHSRGTVKCRHGSNSRRLGR 164
Query: 346 QGHRDEEEDEDVSTERWHQ 364
QG+ +++ S +R+H+
Sbjct: 165 QGNLSSSGNQEGSQKRYHR 183
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 79.0 bits (193), Expect = 1e-14
Identities = 119/637 (18%), Positives = 245/637 (38%), Gaps = 71/637 (11%)
Query: 27 TQQLRGDGLGFRNRNNSTGVAGLSEEASAELRHHLHSPRDH---PDENKDVSTENGHHFW 83
T Q + + R R + L E+ +LR R+ P+E +
Sbjct: 768 TWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRR-- 825
Query: 84 SHPDREKEDEDVSKEYGHLLPGHRSQDHKVGDEGVSGEEVFAEHGGQARGHRGHGSEDTE 143
+REKE + + +E L R+Q + ++G+ ++ Q R + + E
Sbjct: 826 ---EREKELQFLEEEE-QLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLE-E 880
Query: 144 DSAEHRHHLPSHRSHSHQ--------DEDEDEVVSSEHHHHILRHGHRGHDGEDDEGEEE 195
+ RH L + + Q E+E+E+ E + R + E+ +EE
Sbjct: 881 ERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEE 940
Query: 196 EE--EEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEEDDDDDDDD 253
E+ EE E+ E Q + + +E++ + + R + + E+++ ++
Sbjct: 941 EQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEE 1000
Query: 254 DD---DDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSHEEDDNDDDDV 310
+ ++ + E+ Q + EE++ + + R R R + E++ +
Sbjct: 1001 EQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEE 1060
Query: 311 STEYGHQAH-------RHQDHRKEEVEAVSGEHHHHVPDHRHQGHRD----------EEE 353
G + Q ++EE++ + P+ R + R+ +EE
Sbjct: 1061 EQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEE 1120
Query: 354 DEDVSTERWHQGPQHVHHGLVDEEE---EEEEITVQFGHYVASHQPRGHKSDEEDFQDEY 410
++ + ER + Q + +EEE EEE++ + + +EE+ Q E
Sbjct: 1121 EQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQE- 1179
Query: 411 KTEVPHHHHHRVPREEDEEVSAELGHQAPSHRQSHQDEETGHGQRGSIKEMSHHPPGHTV 470
+ ++ + +E + + E Q +Q ++DE+ QR +K P
Sbjct: 1180 EEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDED----QRSDLK-WQWEPEKENA 1234
Query: 471 VKDRSHLRKDDSEEEKEKEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSL 530
V+D K E+ + ED + Q ++ H +Q++ + E+E
Sbjct: 1235 VRDNKVYCKGRENEQFRQLEDSQLRDR------QSQQDLQHLLGEQQERDREQERRRWQQ 1288
Query: 531 NQEEEEEEDKEEEEEEEDEERREERAEVGAPLSPDHSEEE----------EEEEEGLEED 580
EE++ E EE+++ +RR+ +++ L + EE+ EEE+ L+E
Sbjct: 1289 RDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQER 1348
Query: 581 EPRFTIIPNPLDRREEAGGASSEEESGEDTGPQDAQE 617
E + PL R+E EE ++ G + +E
Sbjct: 1349 EEQ------PLRRQERDRKFREEELRHQEQGRKFLEE 1379
Score = 71.6 bits (174), Expect = 2e-12
Identities = 96/543 (17%), Positives = 187/543 (34%), Gaps = 36/543 (6%)
Query: 70 ENKDVSTENGHHFWSHPDREKEDEDVSKEYGHLLPGHRSQDHKVGDEGVSGEEVFAEHGG 129
E + + + GH PD E+ E + Q + + V EE E
Sbjct: 189 EEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRK 248
Query: 130 QARGHRGHGSEDTEDSAEHRHHLPSHRSHSHQDEDED---EVVSSEHHHHILRHGHRGHD 186
+ R + E+ + + L + E ++ E E LR +
Sbjct: 249 RETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRR 308
Query: 187 GEDDEGEEEEEEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEED 246
+++E E++EE E++E + + + EE + Q E
Sbjct: 309 KQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQ 368
Query: 247 DDDDDDDDDDDDDD---DVSIEYRHQAHRHQG----HGIEEDEDVSDGHHHRDPSHRHRS 299
+++ + + + + Q R Q + ++ + R R
Sbjct: 369 EEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE 428
Query: 300 HEEDDNDDDDVSTEYGHQAHRHQDHRKEEVEAVSGEHHHHVPDHRHQGHRDEEEDEDVST 359
EE+ ++ + R Q+ R++ ++ H + Q RD+EE+
Sbjct: 429 QEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEER---R 485
Query: 360 ERWHQGPQHVHHGLVDEEEEEEEITVQFGHYVASHQPRGHKSDEEDFQDEYKTEVP---- 415
ERW + + E++E E ++ Q + +EE Q ++E
Sbjct: 486 ERWLKLEEEERR----EQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRRE 541
Query: 416 --HHHHHRVPREEDEEVSAELGHQAPSHRQSHQDE-----ETGHGQRGSIKEMSHHPPGH 468
+ REE++ + E Q Q + + E Q+ +E
Sbjct: 542 QEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQR 601
Query: 469 TVVKDRSHLRKDDSEEEKEKEEDPGSH--------EEDDESSEQGEKGTHHGSRDQEDEE 520
++ L +++ E++ K E+P EE +E +Q + R+Q +
Sbjct: 602 LKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKR 661
Query: 521 DEEEGHGLSLNQEEEEEEDKEEEEEEEDEERREERAEVGAPLSPDHSEEEEEEEEGLEED 580
+EEE + E EEE +E+E EE++E+ ER + P E E + +
Sbjct: 662 EEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYS 721
Query: 581 EPR 583
PR
Sbjct: 722 RPR 724
Score = 70.1 bits (170), Expect = 7e-12
Identities = 109/552 (19%), Positives = 195/552 (35%), Gaps = 59/552 (10%)
Query: 87 DREKEDEDVSKEYGHLLPGHRSQDHKVGDEGVSGEEVFAEHGGQARGHRGHGSEDTEDSA 146
DR++ DE++ ++ Q+ + +E + EE Q + +GH +E+ D
Sbjct: 165 DRQRRDEELWRQ---------RQEWQEREERRAEEE-------QLQSCKGHETEEFPDEE 208
Query: 147 EHRHH------LPSHRSHSHQDEDEDEVVSSEHHHHILRHGHRGHDGEDDEGEEEEEEEE 200
+ R Q + + V E R E+++ +EEE + +
Sbjct: 209 QLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQ 268
Query: 201 EEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEEDDDDDDDDDDDDDDD 260
E + E + R ++E+ R + EE + ++ + +
Sbjct: 269 RELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERR 328
Query: 261 DVSIEYRHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSHEEDDNDDD---DVSTEYGHQ 317
+ E R Q R + E + + R R EE+ + + Q
Sbjct: 329 EQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQ 388
Query: 318 AHRHQDHRKEEVEAVSGEHHHHVPDHRHQGHRDEE----EDEDVSTERWHQGPQHVHHGL 373
R Q R+E+ + R Q R E+ E E+ E+ H+ Q
Sbjct: 389 LRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHE--QERREQR 446
Query: 374 VDEEEEEEEITVQFGHYVASHQPRGHKSDEEDFQDEYKTEVPHHHHHRVPREEDEEVSAE 433
+ E+EE ++ H+ K + Q+E + E RE+ E +
Sbjct: 447 LKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQ 506
Query: 434 LGHQAPSHRQSH---QDEETGHGQRGSIKEMSHHPPGHTVVKDRSHLRKDDSEEEKEKEE 490
L + R+ Q+EE QR ++ LR++ E ++ +
Sbjct: 507 LRREQEERREQRLKRQEEEERLQQR---------------LRSEQQLRREQEERREQLLK 551
Query: 491 DPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEEED---KEEEEEEE 547
+ E EQ K RDQ + +EE ++EE E +EE E E
Sbjct: 552 REEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLE 611
Query: 548 DEERREERAEVGAPLSPDHSE--EEEEEEEGLEEDEPRFTIIPNPLDRREEAGGASSEEE 605
EERRE+R + P + + EE+EE ++ R +RRE+ EEE
Sbjct: 612 QEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRR-----EQQERREQRLKREEEEE 666
Query: 606 SGEDTGPQDAQE 617
E ++ +E
Sbjct: 667 RLEQRLKREHEE 678
Score = 64.7 bits (156), Expect = 3e-10
Identities = 72/300 (24%), Positives = 119/300 (39%), Gaps = 49/300 (16%)
Query: 322 QDHRKEEVEAVSGEHHHHVPDHRHQGHRDEEEDEDVSTERWHQGPQHVHHGLVDEEEEEE 381
QD R+EE D R RD + +E+ R Q Q L + EE+ E
Sbjct: 111 QDRRQEE-------------DQRRFEPRDRQLEEEPGQRR-RQKRQEQERELAEGEEQSE 156
Query: 382 EITVQFGHYVASHQPRGHKSDEEDFQDEYKTEVPHHHHHRVPREEDEEVSAELGHQA--- 438
+ Q R + D + +E + R E+E++ + GH+
Sbjct: 157 K------------QERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEF 204
Query: 439 PSHRQSHQDEETGHGQRGSIKEMSHHPPGHTVV---KDRSHLRKDDS----EEEKEKEED 491
P Q + E ++G ++ V ++ RK ++ EEEK +EE+
Sbjct: 205 PDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEE 264
Query: 492 PGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGH---GLSLNQEEEEEEDKEEEEEEED 548
P E E EQ K R + EE++++ L +++EEE +++EE E
Sbjct: 265 PQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQ 324
Query: 549 EERREERAEVGAPLSPDHSEEEEEEEEGLEEDEPRFTIIPNPLDRREEAGGASSEEESGE 608
+ERRE++ E EE E++ E++E +RRE+ EEE E
Sbjct: 325 QERREQQEERREQQLRREQEERREQQLRREQEE----------ERREQQLRREQEEERRE 374
Score = 63.9 bits (154), Expect = 5e-10
Identities = 87/452 (19%), Positives = 158/452 (34%), Gaps = 53/452 (11%)
Query: 195 EEEEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEEDDDDDDDDD 254
E++ E+EE E H+ R E E+ D + RH+ D +
Sbjct: 422 EQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQE 481
Query: 255 DDDDDDDVSIEY---RHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSHEEDDNDDDDVS 311
++ + + +E R Q R + E E+ + R + EE++ +
Sbjct: 482 EERRERWLKLEEEERREQQERREQQLRREQEERRE--------QRLKRQEEEERLQQRLR 533
Query: 312 TEYGHQAHRHQDHRKEEVEAVSGEHHHHVPDHRHQGHRDEEEDEDVSTERWHQGPQH--- 368
+E Q R Q+ R+E++ E + R++EE D +R + Q
Sbjct: 534 SE--QQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLK 591
Query: 369 --------------VHHGLVDEEEEEEEITVQFGHYVASHQPRGHKSDEEDFQDEYKTEV 414
L EE E+ + + Q + EE Q + + E
Sbjct: 592 REQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQ 651
Query: 415 PHHHHHRVPREEDEEVSAELGHQAPSHRQSHQDEETGHGQRGSIKEM--SHHPPGHTVVK 472
R+ REE+EE + H + +++E ++ +E S P ++
Sbjct: 652 QERREQRLKREEEEERLEQ--RLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLE 709
Query: 473 DRSHLRKDDSEEEKEKEEDPGSHEEDDESSEQGEKGTHHGSRD----QEDEEDEEEGHGL 528
+ R+ K+E +E +E + E + Q+ EE++
Sbjct: 710 SEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTW 769
Query: 529 SLNQEEEEEEDKEE-------EEEEEDEERREERAEVGAPLSPDHSEEEEEEEEGLE-ED 580
EE+ E ++ E+ E + R EER + P+ E+E+ + E E
Sbjct: 770 QWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREK 829
Query: 581 EPRFTIIPNPLDRREEA-------GGASSEEE 605
E +F L RRE A G ++E
Sbjct: 830 ELQFLEEEEQLQRRERAQQLQEEEDGLQEDQE 861
Score = 63.9 bits (154), Expect = 5e-10
Identities = 96/471 (20%), Positives = 174/471 (36%), Gaps = 59/471 (12%)
Query: 193 EEEEEEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGH---EEDDDD 249
EEE+ E EE++EA + R S+E++ + + EE+
Sbjct: 1295 EEEQLEREEQKEA---------KRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLL 1345
Query: 250 DDDDDDDDDDDDVSIEYRHQAHRHQGHG---IEEDEDVSDGHHHR-----DPSHRHRSHE 301
+ ++ + ++R + RHQ G +EE++ + R + R + E
Sbjct: 1346 QEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQERE 1405
Query: 302 EDDNDDDDVSTEYGHQAHRHQDH----RKEEVEAVSGEHHHHVPDH----RHQGHRDEEE 353
+ D D Q Q+ R+EE + E + R + HR E
Sbjct: 1406 QQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFRE 1465
Query: 354 DEDVSTERWHQGPQHVHHGLVDEE--EEEEEITVQFGHYVASHQPRGHKSDEEDFQDEYK 411
+E + ER Q +H D + EEE+++ Q Q + E F +E +
Sbjct: 1466 EEQLLQEREEQ---QLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQ 1522
Query: 412 TEVPHHHHHRVPREEDEEVSAELGHQAPSHRQSHQDEETGHGQRGSIKEMSHHPPGHTV- 470
+ +EE + E G Q R EE Q +++S
Sbjct: 1523 QLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFR 1582
Query: 471 ---------------VKDRSHLRKDDSEEEKEKEEDPGSHEEDDESSEQGEKGTHHGSRD 515
++D LR+ + +++ +E D E++ E+ E+ H RD
Sbjct: 1583 LEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERD 1642
Query: 516 QEDEEDEEEGHGLSLNQEEEEEEDKEEEEEE----EDEERREERAEVGAPLSPDHSEEEE 571
++ E+E + Q+ + D++ EEE E EE++ R E D EE
Sbjct: 1643 RKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQE------RDRKFREE 1696
Query: 572 EEEEGLEEDEPRFTIIPNPLDRREEAGGASSEEESGEDTGPQDAQEYGNYQ 622
E++ +E E +F L R+E EE+ ++T + + Y+
Sbjct: 1697 EQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYR 1747
Score = 62.0 bits (149), Expect = 2e-09
Identities = 72/377 (19%), Positives = 140/377 (37%), Gaps = 50/377 (13%)
Query: 247 DDDDDDDDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSHEEDDND 306
D ++D + D +E R Q E++ ++++G + R + D
Sbjct: 112 DRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQ-EQERELAEGEEQSEKQERLEQRDRQRRD 170
Query: 307 DDDVSTEYGHQAHRHQDHRKEEVEAVSGEHHHHVPDHRHQGHRDEEEDEDVSTERWHQGP 366
++ Q + +E++++ G PD R+ E E Q
Sbjct: 171 EELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQR 230
Query: 367 QHVHHGLVDEEEEEEEITVQFGHYVASHQPRGHKSDEEDFQDEYKTEVPHHHHHRVPREE 426
+ + EEEE+E K + ++E K + R +EE
Sbjct: 231 RERQDRVFQEEEEKE----------------WRKRETVLRKEEEKLQEEEPQRQRELQEE 274
Query: 427 DEEVSAELGHQAPSHRQSHQDEETGHGQRGSIKEMSHHPPGHTVVKDRSHLRKDDSEEEK 486
+E++ + RQ + ++ QR ++ LR+ EE +
Sbjct: 275 EEQLRKLERQELRRERQEEEQQQ----QR---------------LRREQQLRRKQEEERR 315
Query: 487 EKEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEEEDKEEEEEE 546
E++E+ +E E E+ R+Q+ ++EE L +E+EEE +++ E
Sbjct: 316 EQQEERREQQERREQQEE--------RREQQLRREQEERREQQLRREQEEERREQQLRRE 367
Query: 547 EDEERREERAEVGAPLSPDHS---EEEEEEEEGLEEDEP---RFTIIPNPLDRREEAGGA 600
++EERRE++ L + E++ E+ L ++ + RRE+
Sbjct: 368 QEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRR 427
Query: 601 SSEEESGEDTGPQDAQE 617
EEE E Q+ +E
Sbjct: 428 EQEEERHEQKHEQERRE 444
Score = 56.2 bits (134), Expect = 1e-07
Identities = 105/582 (18%), Positives = 200/582 (34%), Gaps = 60/582 (10%)
Query: 87 DREKEDEDVSKEYGHLLPGHRSQDHKVG-------DEGVSGEEVFAEHGGQARGHRGHGS 139
D + D ++ HLL + +D + D EE + R S
Sbjct: 1255 DSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKS 1314
Query: 140 EDTEDSAEHRHHLPSHRSHSHQDEDEDEVVSSEHHHHILRHGHRGHDGEDDEGEEEEEEE 199
++ + R + + E+E + E LR R ++E +E+
Sbjct: 1315 QEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGR 1374
Query: 200 EEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEEDDDDDDDDDDDDDD 259
+ EE + R R EE + R + E++ + D
Sbjct: 1375 KFLEEEQRL--RRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKF 1432
Query: 260 DDVSIEYRHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSHEEDDN-----DDDDVSTEY 314
+ + R Q + +EE++ + H + E ++ + D E
Sbjct: 1433 REEEQQVRRQERERKF--LEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEE 1490
Query: 315 GHQAHRHQDHRK-EEVEAVSGEHHHHVPDHRHQGHRDEEEDEDVSTERWHQGPQHVHHGL 373
Q R + RK E E S E + Q HR + + + + E+ + +
Sbjct: 1491 EQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRR 1550
Query: 374 VDEEE---EEEEITVQFGHYVASHQPRGHKSDEEDFQDEYKTEVPHHHHHRVPREEDEEV 430
D + EEE++ + S Q R K E+ +V R E+++++
Sbjct: 1551 QDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEE------QKVRRQEQERKFMEDEQQL 1604
Query: 431 SAELGHQA---PSHRQSHQDEETGHGQRGSIKEMSHHPPGHTVVKDRSHLRKDDSEEEKE 487
+ G Q R+ +DE+ Q +++ +++ LR+ + E++
Sbjct: 1605 RRQEGQQQLRQERDRKFREDEQLL--QEREEQQLHRQERDRKFLEEEPQLRRQEREQQLR 1662
Query: 488 KEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEE-----EGHGLSLNQEEE------- 535
+ D EE+ E E+ RD++ E+E+ E L +E++
Sbjct: 1663 HDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELE 1722
Query: 536 ----EEEDKEEEEEEEDEERREERAEV--GAPLSPDHSEEE---------EEEEEGLEED 580
EEE +E E+E R+E ++ L P+ E++ EEE L ++
Sbjct: 1723 RKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQE 1782
Query: 581 EPRFTIIPNPLDRREEAGGASSEEESGEDTGPQDAQEYGNYQ 622
+ DR+ +E + PQ Q G Y+
Sbjct: 1783 REEQQLRSQESDRKFREEEQLRQEREEQQLRPQ--QRDGKYR 1822
Score = 56.2 bits (134), Expect = 1e-07
Identities = 92/486 (18%), Positives = 177/486 (36%), Gaps = 45/486 (9%)
Query: 140 EDTEDSAEHRHHLPSHRSHSHQDEDEDEVVSSEHHHHILRHGHRGHDGEDDEGEEEEE-E 198
E+ + + RH Q+ +E ++ E L + E D E+E
Sbjct: 1450 EEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELR 1509
Query: 199 EEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEEDDDDDDDDDDDDD 258
+E E E Q HR + E+ G R Q + +++ + +
Sbjct: 1510 SQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERG-QQRRQDRDRKFREEEQLRQERE 1568
Query: 259 DDDVSIEYRHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSHEEDDNDDDDVSTEYGHQA 318
+ +S + R + R + + E + R ED+ + + G Q
Sbjct: 1569 EQQLSRQERDRKFRLEEQKVRRQE-------------QERKFMEDEQQ---LRRQEGQQQ 1612
Query: 319 HRHQDHRK-EEVEAVSGEHHHHVPDHRHQGHRDEEEDEDVSTERWHQGPQHVHHGLVDEE 377
R + RK E E + E H+ RD + E+ R + Q + H +
Sbjct: 1613 LRQERDRKFREDEQLLQEREEQ---QLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKF 1669
Query: 378 EEEEEITVQFGHYVASHQPRGHKSDEEDFQ-------DEYKTEVPHHHHHRVPRE--EDE 428
EEE++ + Q R K EE+ Q ++ E + R+ E+E
Sbjct: 1670 REEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEE 1729
Query: 429 EVSAELGHQAPSHRQSHQ---DEETGHGQRGSIKEMSHHPPGHTVVKDRSHLRKDDSEEE 485
++ E + ++ ++ +EE +R ++ ++ LR++ E++
Sbjct: 1730 QLRQETEQEQLRRQERYRKILEEEQLRPERE--EQQLRRQERDRKFREEEQLRQEREEQQ 1787
Query: 486 -KEKEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEE---EEEDKE 541
+ +E D EE+ E+ E+ RD + +EE+ L L ++E+ +E D++
Sbjct: 1788 LRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQ---LQLEEQEQRLRQERDRQ 1844
Query: 542 EEEEEEDEERREERAEVGAPLSPDHSEEEEEEEEGLEEDEPRFTIIPNPLDRREEAGGAS 601
EE+ + + R E + + +E E L E+ R R + G
Sbjct: 1845 YRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQ--QKEEQRHRQVGEIK 1902
Query: 602 SEEESG 607
S+E G
Sbjct: 1903 SQEGKG 1908
Score = 47.0 bits (110), Expect = 6e-05
Identities = 36/110 (32%), Positives = 50/110 (45%), Gaps = 8/110 (7%)
Query: 479 KDDSEEEKEKEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEEE 538
K+ +++ +EED E D E+ E G + QE E + EG S QE E+
Sbjct: 106 KESLLQDRRQEEDQRRFEPRDRQLEE-EPGQRRRQKRQEQERELAEGEEQSEKQERLEQR 164
Query: 539 DKEEEEEE------EDEERREERAEVGAPLS-PDHSEEEEEEEEGLEEDE 581
D++ +EE E +ER E RAE S H EE +EE L E
Sbjct: 165 DRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRE 214
Score = 36.6 bits (83), Expect = 0.081
Identities = 72/397 (18%), Positives = 134/397 (33%), Gaps = 49/397 (12%)
Query: 160 HQDEDEDEVVSSEHHHHILRHGHRGHDGEDDEGEEEEEEEEEEEEASTEYGHQAHRHRGH 219
H+ + + + + E LR RG D + EEE+ +E + + R R
Sbjct: 1525 HRQQRQRKFLQEEQQ---LRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKF 1581
Query: 220 GSEED------------EDVSDGHHHHGPSHRHQGHEEDDDDDDDDDDDDDDDDVSIEYR 267
EE ED G Q + +D+ + ++ + + R
Sbjct: 1582 RLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQER 1641
Query: 268 HQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSHEEDDNDDDDVSTEYGHQAHRHQDH--R 325
+ + + E H RD R + ++ + + + R ++ R
Sbjct: 1642 DRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLR 1701
Query: 326 KEEVEAVSGEHHHHVPDHRHQGHRDEEEDEDVSTERWHQGPQHVHHGLVDEEE-----EE 380
++E E + + + EEE TE+ Q + +++EE+ EE
Sbjct: 1702 RQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREE 1761
Query: 381 EEITVQ-----FGHYVASHQPRGH---KSDEED--FQDEYKTEVPHHHHHRVPREED--- 427
+++ Q F Q R +S E D F++E + P++ D
Sbjct: 1762 QQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKY 1821
Query: 428 --EEVSAELGHQAPSHRQS----HQDEETGHGQRGSIKE----MSHHPPGHTVVKDRS-- 475
EE +L Q RQ ++ EE Q S +E ++R
Sbjct: 1822 RWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLR 1881
Query: 476 --HLRKDDSEEEKEKEEDPGSHEEDDESSEQGEKGTH 510
H+R+ EE++ ++ +E E GTH
Sbjct: 1882 EEHIRRQQKEEQRHRQVGEIKSQEGKGHGRLLEPGTH 1918
Score = 33.5 bits (75), Expect = 0.69
Identities = 28/97 (28%), Positives = 39/97 (40%), Gaps = 14/97 (14%)
Query: 499 DESSEQGEKGTHHGSRDQEDEED------------EEEGHGLSLNQEEEEEEDKEEEEEE 546
DE G +D+ EED EE G ++E+E E E EE+
Sbjct: 96 DEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQS 155
Query: 547 EDEERRE--ERAEVGAPLSPDHSEEEEEEEEGLEEDE 581
E +ER E +R L E +E EE EE++
Sbjct: 156 EKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQ 192
Score = 30.4 bits (67), Expect = 5.8
Identities = 26/86 (30%), Positives = 38/86 (44%), Gaps = 17/86 (19%)
Query: 518 DEEDEEEGHGL-SLNQEEEEEEDKEEEE------EEEDEERREERAEVGAPLSPDHSEEE 570
DEE G SL Q+ +EED+ E EEE +RR ++ + E+E
Sbjct: 96 DEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQ----------EQE 145
Query: 571 EEEEEGLEEDEPRFTIIPNPLDRREE 596
E EG E+ E + + RR+E
Sbjct: 146 RELAEGEEQSEKQERLEQRDRQRRDE 171
>gi|94536805 splicing factor YT521-B isoform 2 [Homo sapiens]
Length = 709
Score = 77.8 bits (190), Expect = 3e-14
Identities = 62/204 (30%), Positives = 88/204 (43%), Gaps = 20/204 (9%)
Query: 412 TEVPHHHHHRVPREE--DEEVSAELGHQAPSHRQSHQDEETGHGQRGSIKEMSHHPPGHT 469
TE + + R R + D + L A +Q E+T +R + P +
Sbjct: 93 TEYKNEEYQRSERNKRLDADRKIRLSSSASREPYKNQPEKTCVRKRDPERRAKSPTPDGS 152
Query: 470 ----VVKDRSHLRKDDSEEEKEKEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEG 525
+ DR R S +E+ E+ GS E S E+G + + ++ EED EE
Sbjct: 153 ERIGLEVDRRASRSSQSSKEEVNSEEYGSDHETGSSGSSDEQGNNTENEEEGVEEDVEED 212
Query: 526 HGLSLNQEEEEEEDKEEEEEEEDEERREERAEVGAPLSPDHSEEEEEEEEGLEEDEPRFT 585
+ + EE+EE D++ EEEEE+EE E EEEEEEEE E+DE
Sbjct: 213 EEVEEDAEEDEEVDEDGEEEEEEEEEEE--------------EEEEEEEEEYEQDERDQK 258
Query: 586 IIPNPLDRREEAGGASSEEESGED 609
N D R EA + SE S D
Sbjct: 259 EEGNDYDTRSEASDSGSESVSFTD 282
Score = 51.2 bits (121), Expect = 3e-06
Identities = 38/131 (29%), Positives = 55/131 (41%), Gaps = 15/131 (11%)
Query: 94 DVSKEYGHLLPGHRSQDHKVGDEGVSGEEVFAEHGGQARGHRGHGSEDTEDSAEHRHHLP 153
D S+ G + S+ + E V+ EE ++H + G +TE+ E
Sbjct: 150 DGSERIGLEVDRRASRSSQSSKEEVNSEEYGSDHETGSSGSSDEQGNNTENEEEGVEEDV 209
Query: 154 SHRSHSHQDEDEDEVVSSEHHHHILRHGHRGHDGEDDEGEEEEEEEEEEEEASTEYGHQA 213
+D +EDE V DGE++E EEEEEEEEEEEE EY
Sbjct: 210 EEDEEVEEDAEEDEEVDE--------------DGEEEE-EEEEEEEEEEEEEEEEYEQDE 254
Query: 214 HRHRGHGSEED 224
+ G++ D
Sbjct: 255 RDQKEEGNDYD 265
Score = 47.0 bits (110), Expect = 6e-05
Identities = 34/148 (22%), Positives = 66/148 (44%), Gaps = 26/148 (17%)
Query: 142 TEDSAEHRHHLPSHRSHSHQDEDEDEVVSSEHH---HHILRHGHRGHDGEDDEGEEEEEE 198
T D +E R L R S + E V+SE + H G G + E EEE E
Sbjct: 148 TPDGSE-RIGLEVDRRASRSSQSSKEEVNSEEYGSDHETGSSGSSDEQGNNTENEEEGVE 206
Query: 199 EEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEEDDDDDDDDDDDDD 258
E+ EE+ E +EEDE+V + EE+++++++++++++
Sbjct: 207 EDVEEDEEVE----------EDAEEDEEVD------------EDGEEEEEEEEEEEEEEE 244
Query: 259 DDDVSIEYRHQAHRHQGHGIEEDEDVSD 286
+++ E + + +G+ + + SD
Sbjct: 245 EEEEEYEQDERDQKEEGNDYDTRSEASD 272
Score = 45.4 bits (106), Expect = 2e-04
Identities = 35/180 (19%), Positives = 70/180 (38%), Gaps = 3/180 (1%)
Query: 397 RGHKSDEEDFQDEYKTEVPHHHHHRVPREEDEEVSAELGHQAPSHRQSHQDEE---TGHG 453
R KS D + EV ++E S E G + DE+ T +
Sbjct: 142 RRAKSPTPDGSERIGLEVDRRASRSSQSSKEEVNSEEYGSDHETGSSGSSDEQGNNTENE 201
Query: 454 QRGSIKEMSHHPPGHTVVKDRSHLRKDDSEEEKEKEEDPGSHEEDDESSEQGEKGTHHGS 513
+ G +++ ++ + +D EEE+E+EE+ EE++E EQ E+
Sbjct: 202 EEGVEEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQKEEG 261
Query: 514 RDQEDEEDEEEGHGLSLNQEEEEEEDKEEEEEEEDEERREERAEVGAPLSPDHSEEEEEE 573
D + + + S++ + + +++++ +RA +P+ D S E
Sbjct: 262 NDYDTRSEASDSGSESVSFTDGSVRSGSGTDGSDEKKKERKRARGISPIVFDRSGSSASE 321
Score = 45.1 bits (105), Expect = 2e-04
Identities = 37/165 (22%), Positives = 61/165 (36%), Gaps = 32/165 (19%)
Query: 84 SHPDREKEDEDVSKEYGHLLPGHRSQDHKVGDEGVSGEEVFAEHGGQARGHRGHGSEDTE 143
S + ++E S+EYG DH+ G G S E+ G+ +E+ E
Sbjct: 164 SRSSQSSKEEVNSEEYG--------SDHETGSSGSSDEQ-------------GNNTENEE 202
Query: 144 DSAEHRHHLPSHRSHSHQDEDEDEVVSSEHHHHILRHGHRGHDGEDDEGEEEEEEEEEEE 203
+ E +EDE+ +E + G + E++E EEEEEEEEE E
Sbjct: 203 EGVEE-----------DVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYE 251
Query: 204 EASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEEDDD 248
+ + + + + D G G + D+
Sbjct: 252 QDERDQKEEGNDYDTRSEASDSGSESVSFTDGSVRSGSGTDGSDE 296
Score = 41.2 bits (95), Expect = 0.003
Identities = 27/131 (20%), Positives = 56/131 (42%), Gaps = 11/131 (8%)
Query: 188 EDDEGEEEEEEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEEDD 247
E D + +EE S EYG H GS +++ + + +G EED
Sbjct: 158 EVDRRASRSSQSSKEEVNSEEYGSD-HETGSSGSSDEQG-------NNTENEEEGVEEDV 209
Query: 248 DDDDDDDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSHEEDDNDD 307
++D++ ++D ++D+ E + EE+E+ + + R + E +D D
Sbjct: 210 EEDEEVEEDAEEDE---EVDEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQKEEGNDYDT 266
Query: 308 DDVSTEYGHQA 318
+++ G ++
Sbjct: 267 RSEASDSGSES 277
Score = 35.4 bits (80), Expect = 0.18
Identities = 33/142 (23%), Positives = 53/142 (37%), Gaps = 19/142 (13%)
Query: 291 RDPSHRHRSHEEDDNDDDDVSTEYGHQAHRHQDHRKEEVEAVSGEHHHHVPDHR---HQG 347
RDP R +S D ++ + E +A R KEEV + H QG
Sbjct: 138 RDPERRAKSPTPDGSER--IGLEVDRRASRSSQSSKEEVNSEEYGSDHETGSSGSSDEQG 195
Query: 348 HRDEEEDEDVSTERWHQGPQHVHHGLVDEEEEEEEITVQFGHYVASHQPRGHKSDEEDFQ 407
+ E E+E V + EE+EE E + V + +EE+ +
Sbjct: 196 NNTENEEEGVEEDV--------------EEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEE 241
Query: 408 DEYKTEVPHHHHHRVPREEDEE 429
+E + E + R +EE +
Sbjct: 242 EEEEEEEEYEQDERDQKEEGND 263
Score = 30.8 bits (68), Expect = 4.5
Identities = 35/194 (18%), Positives = 65/194 (33%), Gaps = 32/194 (16%)
Query: 189 DDEGEEEEEEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEEDDD 248
D E + + E E +A R EE G H S G ++
Sbjct: 139 DPERRAKSPTPDGSERIGLEVDRRASRSSQSSKEEVNSEEYGSDHETGS---SGSSDEQG 195
Query: 249 DDDDDDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSHEEDDNDDD 308
++ +++++ ++DV EEDE+V + EED+ D+
Sbjct: 196 NNTENEEEGVEEDV----------------EEDEEVEE------------DAEEDEEVDE 227
Query: 309 DVSTEYGHQAHRHQDHRKEEVEAVSGEHHHHVPDHRHQGHRDEEEDEDVSTERWHQGPQH 368
D E + ++ +EE E + + R E D + + G
Sbjct: 228 D-GEEEEEEEEEEEEEEEEEEEEYEQDERDQKEEGNDYDTRSEASDSGSESVSFTDGSVR 286
Query: 369 VHHGLVDEEEEEEE 382
G +E+++E
Sbjct: 287 SGSGTDGSDEKKKE 300
Score = 30.8 bits (68), Expect = 4.5
Identities = 22/131 (16%), Positives = 46/131 (35%)
Query: 257 DDDDDVSIEYRHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSHEEDDNDDDDVSTEYGH 316
D + + +E +A R EE G H S + ++ ++++ E
Sbjct: 150 DGSERIGLEVDRRASRSSQSSKEEVNSEEYGSDHETGSSGSSDEQGNNTENEEEGVEEDV 209
Query: 317 QAHRHQDHRKEEVEAVSGEHHHHVPDHRHQGHRDEEEDEDVSTERWHQGPQHVHHGLVDE 376
+ + EE E V + + + +EEE+E+ + Q + + E
Sbjct: 210 EEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQKEEGNDYDTRSE 269
Query: 377 EEEEEEITVQF 387
+ +V F
Sbjct: 270 ASDSGSESVSF 280
>gi|72534750 splicing factor YT521-B isoform 1 [Homo sapiens]
Length = 727
Score = 77.8 bits (190), Expect = 3e-14
Identities = 62/204 (30%), Positives = 88/204 (43%), Gaps = 20/204 (9%)
Query: 412 TEVPHHHHHRVPREE--DEEVSAELGHQAPSHRQSHQDEETGHGQRGSIKEMSHHPPGHT 469
TE + + R R + D + L A +Q E+T +R + P +
Sbjct: 93 TEYKNEEYQRSERNKRLDADRKIRLSSSASREPYKNQPEKTCVRKRDPERRAKSPTPDGS 152
Query: 470 ----VVKDRSHLRKDDSEEEKEKEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEG 525
+ DR R S +E+ E+ GS E S E+G + + ++ EED EE
Sbjct: 153 ERIGLEVDRRASRSSQSSKEEVNSEEYGSDHETGSSGSSDEQGNNTENEEEGVEEDVEED 212
Query: 526 HGLSLNQEEEEEEDKEEEEEEEDEERREERAEVGAPLSPDHSEEEEEEEEGLEEDEPRFT 585
+ + EE+EE D++ EEEEE+EE E EEEEEEEE E+DE
Sbjct: 213 EEVEEDAEEDEEVDEDGEEEEEEEEEEE--------------EEEEEEEEEYEQDERDQK 258
Query: 586 IIPNPLDRREEAGGASSEEESGED 609
N D R EA + SE S D
Sbjct: 259 EEGNDYDTRSEASDSGSESVSFTD 282
Score = 51.2 bits (121), Expect = 3e-06
Identities = 38/131 (29%), Positives = 55/131 (41%), Gaps = 15/131 (11%)
Query: 94 DVSKEYGHLLPGHRSQDHKVGDEGVSGEEVFAEHGGQARGHRGHGSEDTEDSAEHRHHLP 153
D S+ G + S+ + E V+ EE ++H + G +TE+ E
Sbjct: 150 DGSERIGLEVDRRASRSSQSSKEEVNSEEYGSDHETGSSGSSDEQGNNTENEEEGVEEDV 209
Query: 154 SHRSHSHQDEDEDEVVSSEHHHHILRHGHRGHDGEDDEGEEEEEEEEEEEEASTEYGHQA 213
+D +EDE V DGE++E EEEEEEEEEEEE EY
Sbjct: 210 EEDEEVEEDAEEDEEVDE--------------DGEEEE-EEEEEEEEEEEEEEEEYEQDE 254
Query: 214 HRHRGHGSEED 224
+ G++ D
Sbjct: 255 RDQKEEGNDYD 265
Score = 47.0 bits (110), Expect = 6e-05
Identities = 34/148 (22%), Positives = 66/148 (44%), Gaps = 26/148 (17%)
Query: 142 TEDSAEHRHHLPSHRSHSHQDEDEDEVVSSEHH---HHILRHGHRGHDGEDDEGEEEEEE 198
T D +E R L R S + E V+SE + H G G + E EEE E
Sbjct: 148 TPDGSE-RIGLEVDRRASRSSQSSKEEVNSEEYGSDHETGSSGSSDEQGNNTENEEEGVE 206
Query: 199 EEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEEDDDDDDDDDDDDD 258
E+ EE+ E +EEDE+V + EE+++++++++++++
Sbjct: 207 EDVEEDEEVE----------EDAEEDEEVD------------EDGEEEEEEEEEEEEEEE 244
Query: 259 DDDVSIEYRHQAHRHQGHGIEEDEDVSD 286
+++ E + + +G+ + + SD
Sbjct: 245 EEEEEYEQDERDQKEEGNDYDTRSEASD 272
Score = 45.1 bits (105), Expect = 2e-04
Identities = 37/165 (22%), Positives = 61/165 (36%), Gaps = 32/165 (19%)
Query: 84 SHPDREKEDEDVSKEYGHLLPGHRSQDHKVGDEGVSGEEVFAEHGGQARGHRGHGSEDTE 143
S + ++E S+EYG DH+ G G S E+ G+ +E+ E
Sbjct: 164 SRSSQSSKEEVNSEEYG--------SDHETGSSGSSDEQ-------------GNNTENEE 202
Query: 144 DSAEHRHHLPSHRSHSHQDEDEDEVVSSEHHHHILRHGHRGHDGEDDEGEEEEEEEEEEE 203
+ E +EDE+ +E + G + E++E EEEEEEEEE E
Sbjct: 203 EGVEE-----------DVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYE 251
Query: 204 EASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEEDDD 248
+ + + + + D G G + D+
Sbjct: 252 QDERDQKEEGNDYDTRSEASDSGSESVSFTDGSVRSGSGTDGSDE 296
Score = 41.2 bits (95), Expect = 0.003
Identities = 27/131 (20%), Positives = 56/131 (42%), Gaps = 11/131 (8%)
Query: 188 EDDEGEEEEEEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEEDD 247
E D + +EE S EYG H GS +++ + + +G EED
Sbjct: 158 EVDRRASRSSQSSKEEVNSEEYGSD-HETGSSGSSDEQG-------NNTENEEEGVEEDV 209
Query: 248 DDDDDDDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSHEEDDNDD 307
++D++ ++D ++D+ E + EE+E+ + + R + E +D D
Sbjct: 210 EEDEEVEEDAEEDE---EVDEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQKEEGNDYDT 266
Query: 308 DDVSTEYGHQA 318
+++ G ++
Sbjct: 267 RSEASDSGSES 277
Score = 37.0 bits (84), Expect = 0.062
Identities = 48/212 (22%), Positives = 78/212 (36%), Gaps = 29/212 (13%)
Query: 291 RDPSHRHRSHEEDDNDDDDVSTEYGHQAHRHQDHRKEEVEAVSGEHHHHVPDHR---HQG 347
RDP R +S D ++ + E +A R KEEV + H QG
Sbjct: 138 RDPERRAKSPTPDGSER--IGLEVDRRASRSSQSSKEEVNSEEYGSDHETGSSGSSDEQG 195
Query: 348 HRDEEEDEDVSTERWHQGPQHVHHGLVDEEEEEEEITVQFGHYVASHQPRGHKSDEEDFQ 407
+ E E+E V + EE+EE E + V + +EE+ +
Sbjct: 196 NNTENEEEGVEEDV--------------EEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEE 241
Query: 408 DEYKTEVPHHHHHRVPREEDEEV-----SAELGHQAPSHRQSHQDEETGHGQRGS---IK 459
+E + E + R +EE + +++ G ++ S +G G GS K
Sbjct: 242 EEEEEEEEYEQDERDQKEEGNDYDTRSEASDSGSESVSFTDG--SVRSGSGTDGSDEKKK 299
Query: 460 EMSHHPPGHTVVKDRSHLRKDDSEEEKEKEED 491
E +V DRS +S EK+ +
Sbjct: 300 ERKRARGISPIVFDRSGSSASESYAGSEKKHE 331
Score = 30.8 bits (68), Expect = 4.5
Identities = 22/131 (16%), Positives = 46/131 (35%)
Query: 257 DDDDDVSIEYRHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSHEEDDNDDDDVSTEYGH 316
D + + +E +A R EE G H S + ++ ++++ E
Sbjct: 150 DGSERIGLEVDRRASRSSQSSKEEVNSEEYGSDHETGSSGSSDEQGNNTENEEEGVEEDV 209
Query: 317 QAHRHQDHRKEEVEAVSGEHHHHVPDHRHQGHRDEEEDEDVSTERWHQGPQHVHHGLVDE 376
+ + EE E V + + + +EEE+E+ + Q + + E
Sbjct: 210 EEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQKEEGNDYDTRSE 269
Query: 377 EEEEEEITVQF 387
+ +V F
Sbjct: 270 ASDSGSESVSF 280
>gi|153251865 hypothetical protein LOC84226 [Homo sapiens]
Length = 1984
Score = 77.4 bits (189), Expect = 4e-14
Identities = 111/542 (20%), Positives = 158/542 (29%), Gaps = 106/542 (19%)
Query: 72 KDVSTENGHHFWSHPDREKEDEDVS------KEYGHLLPG----------------HRSQ 109
KD S+ + +F+ + +E +++S + G +LPG H+
Sbjct: 1480 KDSSSRSKKNFYRNETSSQESKNLSTPGTRVQARGRILPGSPVKRTWHRHLKDKLTHKEH 1539
Query: 110 DHK--VGDEGVSGEEVFAEHGGQARGHRGHGSEDTEDSAEHRHHLPSHRSH------SHQ 161
+H + G H R HR S E RHH PS RSH +H
Sbjct: 1540 NHPSFYRERTPRGPSERTRHNPSWRNHRSPSERSQRSSLERRHHSPSQRSHCSPSRKNHS 1599
Query: 162 DEDEDEVVSSEHHHHILRHGHRGHDGEDDEGEEEEEEEEEEEEASTEYGHQAHRHRGHGS 221
E S +H R + G + + + + R S
Sbjct: 1600 SPSERSWRSPSQRNH-CSPPERSCHSLSERGLHSPSQRSHRGPSQRRHHSPSERSHRSPS 1658
Query: 222 EEDEDVSDGHHHHGPSHR-HQGHEEDDDDDDDDDDDDDDDDVSIEYRHQAHRHQGHGIEE 280
E S H PS R H+G E E RH++ + H
Sbjct: 1659 ERSHRSSSERRHRSPSQRSHRGPSERSHCSPS------------ERRHRSPSQRSH---- 1702
Query: 281 DEDVSDGHHHRDPSHRHRSHEEDDNDDDDVSTEYGHQAHRHQDHRKEEVEAVSGEHHHHV 340
S+ HH HRS ++HR R + E HH
Sbjct: 1703 -RGPSERRHHSPSKRSHRSP--------------ARRSHRSPSERSHHSPS---ERSHHS 1744
Query: 341 PDHRHQGHRDEEEDEDVSTERWHQGPQHVHHGLVDEEEEEEEITVQFGHYVASHQPRGHK 400
P R H E +ER H P H E + H+ S R H
Sbjct: 1745 PSERRH-HSPSERSHCSPSERSHCSPSERRHR--SPSERRHHSPSEKSHH--SPSERSHH 1799
Query: 401 SDEEDFQDEYKTEVPHHHHHRVPREEDEEVSAELGHQAPSHRQSHQDEETGHGQRGSIKE 460
S P P E E H++PS R+SH+ E H + I E
Sbjct: 1800 S-------------PSERRRHSPLERSRHSLLERSHRSPSERRSHRSFERSHRR---ISE 1843
Query: 461 MSHHPPGHTVVKDRSHLRKDDSEEEKEKEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEE 520
SH P ++SHL E + + H ++ + +H
Sbjct: 1844 RSHSP------SEKSHL--SPLERSRCSPSERRGHSSSGKTCHSPSERSHRSPSGMRQGR 1895
Query: 521 DEEEGHGLSLNQEEEEEEDKEEEEEEEDEERREERAEVGAPLSPDHSEEEEEEEEGLEED 580
E H S E E R R SP +EGL+
Sbjct: 1896 TSERSHRSSC-----------ERTRHSPSEMRPGRPSGRNHCSPSERSRRSPLKEGLKYS 1944
Query: 581 EP 582
P
Sbjct: 1945 FP 1946
Score = 73.9 bits (180), Expect = 5e-13
Identities = 87/415 (20%), Positives = 122/415 (29%), Gaps = 78/415 (18%)
Query: 50 SEEASAELRHHLHSPRDHPDENKDVSTENGHHFWSHPDREKEDEDVSKEYGHLLPGHRSQ 109
S+ +S E RHH S R H ++ + W P + H P RS
Sbjct: 1573 SQRSSLERRHHSPSQRSHCSPSRKNHSSPSERSWRSPSQRN----------HCSPPERSC 1622
Query: 110 DHKVGDEGVS--------GEEVFAEHGGQARGHRGHGSEDTEDSAEHRHHLPSHRSHSHQ 161
H + + G+ G H R HR S+E RH PS RSH
Sbjct: 1623 -HSLSERGLHSPSQRSHRGPSQRRHHSPSERSHRSPSERSHRSSSERRHRSPSQRSHRGP 1681
Query: 162 DEDEDEVVSSEHHHHILRHGHRGHDGEDDEGEEEEEEEEEEEEASTEYGHQAHRHRGHGS 221
E S H + HRG E + ++ H++ R H S
Sbjct: 1682 SERSHCSPSERRHRSPSQRSHRG-------------PSERRHHSPSKRSHRSPARRSHRS 1728
Query: 222 EEDEDVSDGHHHHGPSHRHQGHEEDDDDDDDDDDDDDDDDVSIEYRHQAHRHQGH--GIE 279
+ HH PS R H E RH + + H E
Sbjct: 1729 PSERS------HHSPSER--SHHSPS-----------------ERRHHSPSERSHCSPSE 1763
Query: 280 EDEDVSDGHHHRDPSHRHRSHEEDDNDDDDVSTEYGHQAHRHQDHRKEEVEAVSGEHHHH 339
HR PS R R H + S H + H E S H
Sbjct: 1764 RSHCSPSERRHRSPSER-RHHSPSEKSHHSPSERSHHSPSERRRHSPLERSRHSLLERSH 1822
Query: 340 VPDHRHQGHRDEEEDEDVSTERWHQGPQHVHHGLVDEEEEEEEITVQFGHYVASHQPRGH 399
+ HR E +ER H + H ++ + + RGH
Sbjct: 1823 RSPSERRSHRSFERSHRRISERSHSPSEKSHLSPLERSR------------CSPSERRGH 1870
Query: 400 KSDEEDFQDEYKTEVPHHHHHRVPREEDEEVSAELGHQAPSHRQSHQDEETGHGQ 454
S + P HR P + ++E H++ R H E G+
Sbjct: 1871 SSSGKTCHS------PSERSHRSPSGMRQGRTSERSHRSSCERTRHSPSEMRPGR 1919
>gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isoform
3 [Homo sapiens]
Length = 526
Score = 77.0 bits (188), Expect = 5e-14
Identities = 45/136 (33%), Positives = 66/136 (48%), Gaps = 5/136 (3%)
Query: 490 EDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEEEDKEEEEEEEDE 549
+D E S+E + GS ++E+EE+EEE G + EE ++EEEEEEE+E
Sbjct: 11 QDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGST-----SEESEEEEEEEEEEE 65
Query: 550 ERREERAEVGAPLSPDHSEEEEEEEEGLEEDEPRFTIIPNPLDRREEAGGASSEEESGED 609
E +E + S + EEE E+ E+E ++P R+ +EEE GE
Sbjct: 66 EETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEG 125
Query: 610 TGPQDAQEYGNYQPGS 625
T A G+Y P S
Sbjct: 126 TPQSSALTEGDYVPDS 141
Score = 47.8 bits (112), Expect = 4e-05
Identities = 26/100 (26%), Positives = 48/100 (48%), Gaps = 3/100 (3%)
Query: 188 EDDEGEEEEEEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEEDD 247
E G EEEEEEEEEEE E G + EE+E+ + + + E +
Sbjct: 29 ESGSGSEEEEEEEEEEE---EEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSE 85
Query: 248 DDDDDDDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDG 287
++ +D++ ++++ + + + R G E +E+V +G
Sbjct: 86 EEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEG 125
Score = 43.9 bits (102), Expect = 5e-04
Identities = 32/125 (25%), Positives = 57/125 (45%), Gaps = 7/125 (5%)
Query: 426 EDEEVSAELGHQAPSHRQSHQDEETGHGQRGSIKEMSHHPPGHTVVKDRSHLRKDDSEEE 485
E+ ++ ++L + S R++ E+ + GS E + + ++ EEE
Sbjct: 2 EERDLLSDLQDISDSERKT-SSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE 60
Query: 486 KEKEEDPGSHEEDDESSEQGEKGTHHGSRDQ--EDEEDEEEGHGLSLNQEEEEEEDKEEE 543
+E+EE+ E S E E+ S ++ EDEE E E H L + + + + E E
Sbjct: 61 EEEEEE----ETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESE 116
Query: 544 EEEED 548
E EE+
Sbjct: 117 EAEEE 121
Score = 42.0 bits (97), Expect = 0.002
Identities = 29/122 (23%), Positives = 45/122 (36%), Gaps = 14/122 (11%)
Query: 116 EGVSGEEVFAEHGGQARGHRGHGSEDTEDSAEHRHHLPSHRSHSHQDEDEDEVVSSEHHH 175
+ +S E + G GSE+ E+ E S S ++E+E+E E
Sbjct: 11 QDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEE--- 67
Query: 176 HILRHGHRGHDGEDDEGEEEEEEEEEEEEASTEYGH-------QAHRHRGHGSEEDEDVS 228
G + + EE EEE E+E H + R G E +E+V
Sbjct: 68 ----TGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVG 123
Query: 229 DG 230
+G
Sbjct: 124 EG 125
Score = 35.4 bits (80), Expect = 0.18
Identities = 31/98 (31%), Positives = 41/98 (41%), Gaps = 8/98 (8%)
Query: 347 GHRDEEEDEDVSTERWHQGPQHVHHGLVDEEEEEEEITVQFGHYVASHQPRGHKSDEEDF 406
G +EEE+E+ E +G +EEEEEEE AS Q S+EE
Sbjct: 33 GSEEEEEEEEEEEE---EGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMS 89
Query: 407 QDEYKTEVPH---HHHHRVPRE--EDEEVSAELGHQAP 439
+DE + H R R+ E EE E+G P
Sbjct: 90 EDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTP 127
Score = 35.0 bits (79), Expect = 0.24
Identities = 30/117 (25%), Positives = 46/117 (39%), Gaps = 7/117 (5%)
Query: 93 EDVSKEYGHLLPGHRSQDHKVGDEGVSGEEVFAEHGGQARGHRGHGSEDTEDSAEHRHHL 152
E S E G ++ + +EG + EE E + GS E S + +
Sbjct: 24 ESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEV 83
Query: 153 PSHRSHSHQDEDEDEVVSSEHHHHILRHGHRGHD-GEDDEGEEEEEEEEEEEEASTE 208
S ++ EDE +E+H ++ D GE +E EEE E + A TE
Sbjct: 84 ------SEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTE 134
Score = 32.3 bits (72), Expect = 1.5
Identities = 28/124 (22%), Positives = 46/124 (37%), Gaps = 13/124 (10%)
Query: 253 DDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSHEEDDNDDDDVST 312
D D D + + G G EE+E+ + + EE++ ++++ T
Sbjct: 9 DLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEET 68
Query: 313 EYGHQAHRHQDHRKEEV------EAVSGEHHHH---VPDHRHQGHRDEEEDEDVSTERWH 363
G + + EEV E E+ +H VP+ R RD E E+ E
Sbjct: 69 --GSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFD--RDSGESEEAEEEVGE 124
Query: 364 QGPQ 367
PQ
Sbjct: 125 GTPQ 128
Score = 32.3 bits (72), Expect = 1.5
Identities = 25/102 (24%), Positives = 44/102 (43%), Gaps = 16/102 (15%)
Query: 154 SHRSHSHQDEDEDEVVSSEHHHHILRHGHRGHDGEDDEGEEEEEEE--EEEEEASTEYGH 211
S ++E+E+E +SE E++E EEEEEEE EEAS +
Sbjct: 34 SEEEEEEEEEEEEEGSTSEESE------------EEEEEEEEEEEETGSNSEEASEQSAE 81
Query: 212 QAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEEDDDDDDDD 253
+ SE++E ++ H P R + ++ +++
Sbjct: 82 EVSEE--EMSEDEERENENHLLVVPESRFDRDSGESEEAEEE 121
Score = 31.6 bits (70), Expect = 2.6
Identities = 26/115 (22%), Positives = 42/115 (36%), Gaps = 3/115 (2%)
Query: 392 ASHQPRGHKSDEEDFQDEYKTEVPHHHHHRVPREEDEEVSAELGHQAPSHRQSHQDEETG 451
+S G S+EE+ ++E + E EE+EE E EE
Sbjct: 25 SSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVS 84
Query: 452 HGQRGSIKEMSHHPPGHTVVKDRSHLRKDDSEEEKEKEEDPGSHEEDDESSEQGE 506
+ +E + H +V S +D E E E EE+ G + +G+
Sbjct: 85 EEEMSEDEERENE--NHLLVVPESRFDRDSGESE-EAEEEVGEGTPQSSALTEGD 136
>gi|4758172 dentin matrix acidic phosphoprotein 1 isoform 1
precursor [Homo sapiens]
Length = 513
Score = 75.5 bits (184), Expect = 2e-13
Identities = 101/512 (19%), Positives = 175/512 (34%), Gaps = 90/512 (17%)
Query: 152 LPSHRSHSHQDEDEDEVVSSEHHHHILRHGHRGHDGEDDEGEEEEEEEEEEEEASTEYGH 211
LP R +++ ED +E +GH + E E E + S+E
Sbjct: 17 LPVTRYQNNESEDSEE--------------WKGHLAQAPTPPLESSESSEGSKVSSE--E 60
Query: 212 QAHRHRGHGSEEDEDVSDGHHHH-----GPSHRHQGHEEDDDDDDDDDDDDDDDDVSIEY 266
QA+ ++ +E + H + G R G DD DDD+DD DD
Sbjct: 61 QANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFG----- 115
Query: 267 RHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSHEEDDNDDDDVSTEYGHQAHRHQDHRK 326
D+D G R R ++D+DD ++E A + QD +
Sbjct: 116 --------------DDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASE--ESAPQGQDSAQ 159
Query: 327 EEVEAVSGEHHHHVPDHRHQGHRDEEEDEDVSTERWHQGPQHVHHGLVDEEEEEEEITVQ 386
+ D E+ D E G +E E EE V
Sbjct: 160 DTTS--------------ESRELDNEDRVDSKPEG----------GDSTQESESEEHWVG 195
Query: 387 FGHYVASHQPRGHKSDEEDFQDEYKTEVPHHHHHRVPREEDEEVSAELGHQAPSHRQSHQ 446
G S G + D+E Q + + E ++ + ++S +
Sbjct: 196 GGSDGESSHGDGSELDDEGMQSDDPESI-----------RSERGNSRMNSAGMKSKESGE 244
Query: 447 DEETGHGQRGSIKEMSHHPPGHTVVK-------DRSHLRKDDSEEEKEKEEDPGSHEEDD 499
+ E + Q ++ HP K DRS L +++ EE + + S+ D
Sbjct: 245 NSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDT 304
Query: 500 ESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEEEDKEEEEEEEDEERREERAEVG 559
S+ D ++ +EE + E +E +E E + E +E
Sbjct: 305 GLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESR 364
Query: 560 APLSPDHSE---EEEEEEEGLEEDEPRFTIIPNPLDRREEAGGASSEEESGEDTGPQDAQ 616
+PD + E++E+ + EED R E+A SSE + + P+ +
Sbjct: 365 GD-NPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPE 423
Query: 617 EYGNYQPGSLCGYCSFCNRCTECESCHCDEEN 648
+ + L + S ++ E H +E++
Sbjct: 424 DENSSSQEGLQSHSSSAE--SQSEESHSEEDD 453
Score = 68.9 bits (167), Expect = 1e-11
Identities = 116/563 (20%), Positives = 189/563 (33%), Gaps = 125/563 (22%)
Query: 52 EASAELRHHLHSPRDHPDENKDVSTENGHHFWSHPDREKEDEDVSKE--------YGHLL 103
E S E + HL P E+ + S + + + D S+E Y + L
Sbjct: 28 EDSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQSEEGLGSDDHQYIYRL 87
Query: 104 PGHRSQ------DHKVGDEGVSGEEVFAEHGGQARGHRGHGSEDTEDSAEHRHHLPSHRS 157
G S+ D K DE SG++ F + G G +D ++ R
Sbjct: 88 AGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDS------GPGPKDRQEGGNSR-------- 133
Query: 158 HSHQDEDEDEVVSSEHHHHILRHGHRGHDGEDDEGEEEEEEEEEEEEASTEYGHQAHRHR 217
DED D+ + + +G D D E E + E+ S G
Sbjct: 134 -LGSDEDSDDTIQASEES-----APQGQDSAQDTTSESRELDNEDRVDSKPEG------- 180
Query: 218 GHGSEEDEDVSDGHHHHGPSHRHQGHEEDDDDDDDDDDDDDDDDVSIEYRHQAHRHQGHG 277
G E S+ H G S H + + DD+ DD + + E + G
Sbjct: 181 --GDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMK 238
Query: 278 IEEDEDVSDGHHHRD---------PSHR----HRSHEEDDNDDDDVSTEYGHQAHRHQDH 324
+E + S+ + +D PS + R EEDD + D ++
Sbjct: 239 SKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELD------------DNN 286
Query: 325 RKEEVEAVSGEHHHHVPDHRHQGHRDEEED-EDVSTERWHQGPQHVHHGLVDEEEEEEEI 383
EEV++ S E+ + Q RD + D ++ S E Q G E +E +
Sbjct: 287 TMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANL 346
Query: 384 TVQFGHYVASHQPRGHKSDEEDFQDEYKTEVPHHHHHRVPREEDEEVSAELGHQAPSHRQ 443
+ Q +E+ E + + P V +ED + S E SH
Sbjct: 347 SSQ----------ENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEE----DSSHTL 392
Query: 444 SHQDEETGHGQRGSIKEMSHHPPGHTVVKDRSHLRKDDSEEEKEKEEDPGSHEEDDESSE 503
SH E+ Q S + SE EE P S E+++ SS+
Sbjct: 393 SHSKSESREEQADS----------------------ESSESLNFSEESPESPEDENSSSQ 430
Query: 504 QGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEEEDKEEEEEEEDEERREERAEVGAPLS 563
+G + H S E + E+ EE++ D + E
Sbjct: 431 EGLQS--HSS------------------SAESQSEESHSEEDDSDSQDSSRSKEDSNSTE 470
Query: 564 PDHSEEEEEEEEGLEEDEPRFTI 586
S EE+ + + +E + + T+
Sbjct: 471 SKSSSEEDGQLKNIEIESRKLTV 493
Score = 48.9 bits (115), Expect = 2e-05
Identities = 55/245 (22%), Positives = 91/245 (37%), Gaps = 45/245 (18%)
Query: 69 DENKDVSTENGHHFWSHPDREKEDEDVSKEYGHLLPGHRSQDHKVGDEGVSGEEVFAEHG 128
+E K STEN + + + + D G +D K E +S EE G
Sbjct: 289 EEVKSDSTENSNSRDTGLSQPRRDSK----------GDSQEDSK---ENLSQEESQNVDG 335
Query: 129 GQARGHRGHGSEDTEDSAEHRHHLPSHR-------SHSHQDEDEDEVVSSEHHHHILRHG 181
+ + E+S+E + + S + S+ ++ ED S E H L H
Sbjct: 336 PSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHS 395
Query: 182 HRGHDGEDDEGE--------EEEEEEEEEEEASTEYGHQAHR-------HRGHGSEEDED 226
E + E EE E E+E +S++ G Q+H H E+D D
Sbjct: 396 KSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSD 455
Query: 227 VSDGHHHHGPSHRHQGHEEDDDDDDDDDDDDDDDDVSIEYRH---QAHRHQGHGIEEDED 283
D S R + + ++D ++ IE R A+ ++ G ++D D
Sbjct: 456 SQD-------SSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVDAYHNKPIGDQDDND 508
Query: 284 VSDGH 288
DG+
Sbjct: 509 CQDGY 513
Score = 45.1 bits (105), Expect = 2e-04
Identities = 46/195 (23%), Positives = 69/195 (35%), Gaps = 42/195 (21%)
Query: 50 SEEASAELRHHL--HSPRDHPD---------ENKDVSTENGHHFWSHPDREKEDEDVSKE 98
S+E S+E + + S D+PD E+ D S E+ H SH E +E E
Sbjct: 348 SQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSE 407
Query: 99 YGHLLPGHRSQDHKVGDEGVSGEEVFAEHGGQA--RGHRGHGSEDTEDSAEHRHHLPSHR 156
L DE S +E H A + H ED DS +
Sbjct: 408 SSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQD--------S 459
Query: 157 SHSHQDEDEDEVVSSEHHHHILRHGHRGHDGEDDEGEEEEEEEEEEEEASTEYGHQAHRH 216
S S +D + E SS EE+ + + E S + A+ +
Sbjct: 460 SRSKEDSNSTESKSS---------------------SEEDGQLKNIEIESRKLTVDAYHN 498
Query: 217 RGHGSEEDEDVSDGH 231
+ G ++D D DG+
Sbjct: 499 KPIGDQDDNDCQDGY 513
>gi|20270337 Leo1, Paf1/RNA polymerase II complex component, homolog
[Homo sapiens]
Length = 666
Score = 73.2 bits (178), Expect = 8e-13
Identities = 122/642 (19%), Positives = 222/642 (34%), Gaps = 113/642 (17%)
Query: 55 AELRHHLHSPRDHPDENKDVSTENGHHFWSHPDREKEDEDVSKEYGHLLPGHRSQDHKVG 114
A++ S D E KD S D + + E+ + G G S + G
Sbjct: 2 ADMEDLFGSDADSEAERKDSD--------SGSDSDSDQENAAS--GSNASGSESDQDERG 51
Query: 115 DEGV-SGEEVFAEHGGQARGHRGHGSEDTEDSAEHRHHLPSHRSHSHQDEDEDEVVSSEH 173
D G S +E+F + GS++ + +++R S RS H+D D +V +
Sbjct: 52 DSGQPSNKELFGDDSEDEGASHHSGSDNHSERSDNRSEA-SERS-DHEDNDPSDV---DQ 106
Query: 174 HHHILRHGHRGHDGEDDEGEEEEEEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHH 233
H G + ++DEG + E +E H G + D+ + +
Sbjct: 107 HS-----GSEAPNDDEDEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQN 161
Query: 234 HGPSHRHQGHEED------DDDDDDDDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVS-- 285
R QG +ED DD+ + DD++ +S + R Q + +++ V+
Sbjct: 162 SDDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASD 221
Query: 286 ---DGHHHRDPSHRHRSHEEDDNDDDDVSTEYGHQAHRH------QDHRKEEVEAVSGEH 336
+ + D S EE + DD + + HRH QDH+ E E
Sbjct: 222 NDDEKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSED 281
Query: 337 HHHVPDHRHQGHRDEEEDEDVSTERWHQGPQHV-------------------------HH 371
++ D E D D + + G + +
Sbjct: 282 EVLRMKRKNAIASDSEADSDTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDEN 341
Query: 372 GLVDEEEEEEEIT---------------------VQFGHYVA-SHQPRGHKSDEEDFQDE 409
GL +++EEE I V+ ++++ +P + E++F+DE
Sbjct: 342 GLPQDQQEEEPIPETRIEVEIPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEFEDE 401
Query: 410 ----------YKTEVPHHHHHRVPREED----EEVSAELGHQAPSHRQSHQDEETGHGQR 455
K +V + R+ R+E+ +E +A + + H E +
Sbjct: 402 EMLDEEGRTRLKLKVENTIRWRIRRDEEGNEIKESNARIVKWSDGSMSLHLGNEVFDVYK 461
Query: 456 GSIKEMSHH--------PPGHTVVKDRSHLRKDDSEEEKEKEEDPGSHEEDDESSEQGEK 507
++ +H G V K + R ++ ++ D S Q +
Sbjct: 462 APLQGDHNHLFIRQGTGLQGQAVFKTKLTFRPHSTDSATHRKMTLSL--ADRCSKTQKIR 519
Query: 508 GTHHGSRDQEDEEDEEEGHGLSLNQEEEEEEDKEEEEEEEDEERREERAEVGAPLSPDHS 567
RD E + E + +E + E ++ E++ +R + L PD
Sbjct: 520 ILPMAGRDPECQRTEM----IKKEEERLRASIRRESQQRRMREKQHQRGLSASYLEPDRY 575
Query: 568 EEEEEEEEGLEEDEPRFTIIPNPLDRREEAGGASSEEESGED 609
+EEEE EE + + + R + S+E S ED
Sbjct: 576 DEEEEGEESISLAAIKNRYKGGIREERARIYSSDSDEGSEED 617
Score = 65.9 bits (159), Expect = 1e-10
Identities = 74/370 (20%), Positives = 134/370 (36%), Gaps = 77/370 (20%)
Query: 242 GHEEDDDDDDDDDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSHE 301
G + D + + D D D D E G ++DE G PS++
Sbjct: 9 GSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQ----PSNKELFG- 63
Query: 302 EDDNDDDDVSTEYGHQAHRHQDHRKEEVEAVSGEHHHHVPDHRHQGHRDEEEDEDVSTER 361
DD++D+ S G H + + E R + ED D S
Sbjct: 64 -DDSEDEGASHHSGSDNHSERSDNRSEAS-----------------ERSDHEDNDPSDVD 105
Query: 362 WHQGPQHVHHGLVDEEEEEEEITVQFGHYVASHQPRGHKSDEEDFQDEYKTEVPHHHHHR 421
H G + + D+E+E H A + H SD+E + E K++
Sbjct: 106 QHSGSEAPN----DDEDEGHRSDGGSHHSEAEGSEKAH-SDDEKWGREDKSD-------- 152
Query: 422 VPREEDEEVSAELGHQAPSHRQSHQDEETGHGQRGSIKEMSHHPPGHTVVKDRSHLRKDD 481
+ +DE++ Q+ DEE G D L+ D
Sbjct: 153 --QSDDEKI------------QNSDDEERAQGS------------------DEDKLQNSD 180
Query: 482 SEEEKEKEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEEEDKE 541
+E+ + +D + D+ +Q ++E ++E S N +E++ D E
Sbjct: 181 DDEKMQNTDDEERPQLSDDERQQ--------LSEEEKANSDDERPVASDNDDEKQNSDDE 232
Query: 542 EEEEEEDEERREERAEVGAPLSPD-HSEEEEEEEEGLEEDEPRFTIIPNPLDRREEAGGA 600
E+ + DEE+ + + S + H ++EEE+ + + R + + + R +
Sbjct: 233 EQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAI 292
Query: 601 SSEEESGEDT 610
+S+ E+ DT
Sbjct: 293 ASDSEADSDT 302
Score = 59.7 bits (143), Expect = 9e-09
Identities = 61/236 (25%), Positives = 98/236 (41%), Gaps = 40/236 (16%)
Query: 398 GHKSDEEDFQDEYKTEVPHHH----HHRVPREEDEEVSAELGHQA--PSHRQSHQ----- 446
G S++E F D+ + E HH +H + E S H+ PS H
Sbjct: 54 GQPSNKELFGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAP 113
Query: 447 --DEETGHGQRGSIKEMSHHPPGHTVVKDRSHLRKDDSEEEKEKEEDPGSHEEDDESSEQ 504
DE+ GH G SHH K S K E++ ++ +D DDE Q
Sbjct: 114 NDDEDEGHRSDGG----SHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQ 169
Query: 505 GEKGTHHGSRDQEDE---EDEEEGHGLSLNQEEEEEEDKEEEEEEEDEERREERAEVGAP 561
G + D +++ D+EE LS ++E ++ EEE+ D+ER P
Sbjct: 170 GSDEDKLQNSDDDEKMQNTDDEERPQLS---DDERQQLSEEEKANSDDER---------P 217
Query: 562 LSPDHSEEE---EEEEEGLEEDEPRFTIIPNPLDRREEAGGASSEEESGEDTGPQD 614
++ D+ +E+ ++EE+ DE + + N D R +A + E +D QD
Sbjct: 218 VASDNDDEKQNSDDEEQPQLSDEEK---MQNSDDERPQA--SDEEHRHSDDEEEQD 268
Score = 49.3 bits (116), Expect = 1e-05
Identities = 109/616 (17%), Positives = 208/616 (33%), Gaps = 82/616 (13%)
Query: 39 NRNNSTGVAGLSEEASAELRHHLHSPRDHPDENKDVSTENGHHFWSHPDREKEDEDVSKE 98
NR+ ++ + + +++ H S + DE++ ++ G H EK D ++
Sbjct: 86 NRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSHHSEAEGSEKAHSD-DEK 144
Query: 99 YGHLLPGHRSQDHKVGDEGVSGEEVFAEHGGQARGHRGHGSEDTEDSAEHRHHLPSHRSH 158
+G +S D K+ + S +E A+ + + E +++ + P
Sbjct: 145 WGREDKSDQSDDEKIQN---SDDEERAQGSDEDKLQNSDDDEKMQNTDDEER--PQLSDD 199
Query: 159 SHQDEDEDEVVSSEHHHHILRHGHRGHDGEDDEGEEEEEEEEEEEEASTEYGHQAHRHRG 218
Q E+E +S+ + D++ E++ ++EE+ + S E Q
Sbjct: 200 ERQQLSEEEKANSDDERPV---------ASDNDDEKQNSDDEEQPQLSDEEKMQ------ 244
Query: 219 HGSEEDEDVSDGHHHHGPSHRHQGHEEDD---DDDDDD-----------DDDDDDDDVSI 264
+ +E SD H H Q H+ + D +D+ D + D D +
Sbjct: 245 NSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTEV 304
Query: 265 EYRHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSHEEDDNDDDDVSTEYGHQAHRHQDH 324
+ G ++ SDG P + +E+ D E + +
Sbjct: 305 PKDNSGTMDLFGGADDISSGSDGED--KPPTPGQPVDENGLPQDQQEEEPIPETRIEVEI 362
Query: 325 RKEEVEAVSGEHHHHVPDHRH--------QGHRDEEEDEDVSTE----RWHQGPQHVHHG 372
K + + + +P+ Q + DE EDE++ E R ++
Sbjct: 363 PKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLKVENTIRW 422
Query: 373 LVDEEEEEEEITVQFGHYVASHQPRGHKSDEEDFQDEYKTEVPHHHHHRVPREEDEEVSA 432
+ +EE EI V + D YK + H+H R+
Sbjct: 423 RIRRDEEGNEIKESNARIVKWSDGSMSLHLGNEVFDVYKAPLQGDHNHLFIRQGTGLQGQ 482
Query: 433 ELGHQAPSHRQSHQDEETGHGQRGSIKEMSHHPPGHTVVKDRSHLRKDDSEEEKEKEEDP 492
+ + R D T S+ + + L + E ++ E
Sbjct: 483 AVFKTKLTFRPHSTDSATHRKMTLSLADRCSKTQKIRI------LPMAGRDPECQRTEMI 536
Query: 493 GSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEEEDKEEEEEEEDEER- 551
EE +S + E Q +++ GLS + E + D+EEE EE
Sbjct: 537 KKEEERLRASIRRES-------QQRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLAA 589
Query: 552 ---------REERAEVGAPLSPDHSEEEEEEEEGLEEDEPRFTIIPNPLDRREEAGGASS 602
REERA + + +EG EED+ + + L EE +
Sbjct: 590 IKNRYKGGIREERARI----------YSSDSDEGSEEDKAQRLLKAKKLTSDEEGEPSGK 639
Query: 603 EEESGEDTGPQDAQEY 618
+ +D + ++Y
Sbjct: 640 RKAEDDDKANKKHKKY 655
Score = 39.7 bits (91), Expect = 0.010
Identities = 31/144 (21%), Positives = 56/144 (38%), Gaps = 15/144 (10%)
Query: 481 DSEEEKEKEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEEEDK 540
DSE E+ K+ D GS + D+ + DQ++ D + L ++ E+E
Sbjct: 13 DSEAER-KDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEGA 71
Query: 541 EEEE-EEEDEERREERAEVGAPLSPDHSEEEEEEEEGLEEDEPRFTIIPNPLDRREEA-- 597
+ ER + R+E + E + E+ D + + P D +E
Sbjct: 72 SHHSGSDNHSERSDNRSE---------ASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHR 122
Query: 598 --GGASSEEESGEDTGPQDAQEYG 619
GG+ E G + D +++G
Sbjct: 123 SDGGSHHSEAEGSEKAHSDDEKWG 146
Score = 35.0 bits (79), Expect = 0.24
Identities = 32/161 (19%), Positives = 58/161 (36%), Gaps = 19/161 (11%)
Query: 490 EDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEEEDKEEEEEEEDE 549
ED + D E+ + DQE+ G +Q+E + + +E +
Sbjct: 5 EDLFGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGD 64
Query: 550 ERREERAEVGAPLSPDHSEEEEEEEEGLEEDEPRFTIIPNPLDRREEAGGASSEEESGED 609
+ +E A + S +HSE + E E + E+ + ++ SG +
Sbjct: 65 DSEDEGASHHSG-SDNHSERSDNRSEASERSD------------HEDNDPSDVDQHSGSE 111
Query: 610 TGPQDAQEYGNYQPGSLCGYCSFCNRCTECESCHCDEENMG 650
P D ++ G+ G S + E H D+E G
Sbjct: 112 -APNDDEDEGHRSDGG-----SHHSEAEGSEKAHSDDEKWG 146
Score = 34.3 bits (77), Expect = 0.40
Identities = 29/122 (23%), Positives = 54/122 (44%), Gaps = 7/122 (5%)
Query: 422 VPREEDEEVSAELGHQ---APSHRQSHQDEETGHGQRG-SIKEMSHHPPGHTVVKDRSHL 477
+ RE + E HQ + S+ + + +E G+ S+ + + G + ++R+ +
Sbjct: 547 IRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLAAIKNRYKGG-IREERARI 605
Query: 478 RKDDSEEEKEKEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEE 537
DS+E E ED + E+G G R ED++ + H + +EEEE
Sbjct: 606 YSSDSDEGSE--EDKAQRLLKAKKLTSDEEGEPSGKRKAEDDDKANKKHKKYVISDEEEE 663
Query: 538 ED 539
+D
Sbjct: 664 DD 665
>gi|221316599 chromogranin B precursor [Homo sapiens]
Length = 677
Score = 72.8 bits (177), Expect = 1e-12
Identities = 95/482 (19%), Positives = 167/482 (34%), Gaps = 51/482 (10%)
Query: 87 DREKEDEDVSKEYGHLL--PGHRSQDHKV---GDEGVSGEEVFAEHGGQARGHRGHGSED 141
D+E + + +K LL P S+ H+ G+ G GEE +G D
Sbjct: 70 DKETTENENTKFEVRLLRDPADASEAHESSSRGEAGAPGEEDI----------QGPTKAD 119
Query: 142 TEDSAEHRHHLPSHRSHSH-----QDEDEDEVVSSEHHHHILRHGHRGHDGED----DEG 192
TE AE H D E V + H R +GE+ + G
Sbjct: 120 TEKWAEGGGHSRERADEPQWSLYPSDSQVSEEVKTRHSEKSQREDEEEEEGENYQKGERG 179
Query: 193 EEEEEEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEEDDDDDDD 252
E+ EE+ EE T+ R + +++E V+ H + + H + +
Sbjct: 180 EDSSEEKHLEEPGETQNAFLNERKQASAIKKEELVARSETHAAGHSQEKTHSREKSSQES 239
Query: 253 DDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSHEEDDNDDDDVST 312
++ ++ E + Q + E++ S+ R H D S
Sbjct: 240 GEETGSQENHPQESKGQPRSQEESEEGEEDATSEVDKRRTRPRHHHGRSRPDRSSQGGSL 299
Query: 313 EYGHQAHRHQDHRKEEVEAVS-GEHHHHVPDHRHQGHRDEEEDEDVSTERWHQGPQHVHH 371
+ H ++ + V S GE H H + E E++ Q P
Sbjct: 300 PSEEKGHPQEESEESNVSMASLGEKRDHHSTHYRASEEEPEYGEEIKGYPGVQAP----- 354
Query: 372 GLVDEEEEEEEITVQFGHYVASHQPRGHKSDEEDFQDEYKTEVPHHHHHRVPREEDEEVS 431
E+ E E + + +P+ +S +E+ + Y + H E +EE
Sbjct: 355 ----EDLEWERYRGRGSEEYRAPRPQSEESWDEEDKRNYPSLELDKMAHGYGEESEEERG 410
Query: 432 AELGHQAPSHRQSHQDEETGHGQRGSIKEMSHHPPGHTVVKDRSHLRKDDSEEEKEKEED 491
E G H + E + + +E GH R +++ +K +
Sbjct: 411 LEPG--KGRHHRGRGGEPRAYFMSDTREEKRFLGEGHH--------RVQENQMDKARRHP 460
Query: 492 PGSHEEDDES-SEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEEEDKEEEEEEEDEE 550
G+ +E D + GE+G + Q D +D +E N+EE +DK+ E+
Sbjct: 461 QGAWKELDRNYLNYGEEGAPGKWQQQGDLQDTKE------NREEARFQDKQYSSHHTAEK 514
Query: 551 RR 552
R+
Sbjct: 515 RK 516
Score = 62.0 bits (149), Expect = 2e-09
Identities = 108/472 (22%), Positives = 167/472 (35%), Gaps = 83/472 (17%)
Query: 186 DGEDDEGEEEEEEEEE----EEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQ 241
D +D E E E + E + A H++ G+ +ED+ GP+
Sbjct: 67 DVKDKETTENENTKFEVRLLRDPADASEAHESSSRGEAGAPGEEDIQ------GPTKADT 120
Query: 242 -------GHEEDDDDDDDDDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDGHHHRDPS 294
GH + D+ D VS E + RH EDE+ +G +++
Sbjct: 121 EKWAEGGGHSRERADEPQWSLYPSDSQVSEEVKT---RHSEKSQREDEEEEEGENYQKGE 177
Query: 295 HRHRSHEEDDNDDD-DVSTEYGHQAHRHQDHRKEEVEAVSGEH---HHHVPDHRHQGHRD 350
S EE ++ + + ++ + +KEE+ A S H H H +
Sbjct: 178 RGEDSSEEKHLEEPGETQNAFLNERKQASAIKKEELVARSETHAAGHSQEKTHSREKSSQ 237
Query: 351 EEEDEDVSTERWHQGPQHVHHGLVDEEEEEEEITVQFGHYVASHQPRGHKSDEEDFQDEY 410
E +E S E Q + + EE EE+ T + D+
Sbjct: 238 ESGEETGSQENHPQESKGQPRSQEESEEGEEDATSEV--------------------DKR 277
Query: 411 KTEVPHHHHHRVPREEDEEVSAELGHQAPSHRQSHQDEETGHGQ--RGSIKEMSHHPPGH 468
+T HHH P + G PS + H EE+ S+ E H
Sbjct: 278 RTRPRHHHGRSRPDRSSQ------GGSLPSEEKGHPQEESEESNVSMASLGEKRDH---- 327
Query: 469 TVVKDRSHLRKDDSEEEKEKEED----PGSHEEDDESSEQGE-------KGTHHGSRDQE 517
+H R SEEE E E+ PG +D E+ + S +
Sbjct: 328 ----HSTHYRA--SEEEPEYGEEIKGYPGVQAPEDLEWERYRGRGSEEYRAPRPQSEESW 381
Query: 518 DEEDEEEGHGLSLNQEEEEE-EDKEEEEEEEDEERREERAEVGAPLSPDHSEEEEEEEEG 576
DEED+ L L++ E+ EEE E + R R G P + S + EE+
Sbjct: 382 DEEDKRNYPSLELDKMAHGYGEESEEERGLEPGKGRHHRGRGGEPRAYFMS-DTREEKRF 440
Query: 577 LEEDEPRFTIIPNPLDR-REEAGGASSEEES-----GEDTGPQDAQEYGNYQ 622
L E R + N +D+ R GA E + GE+ P Q+ G+ Q
Sbjct: 441 LGEGHHR--VQENQMDKARRHPQGAWKELDRNYLNYGEEGAPGKWQQQGDLQ 490
Score = 47.8 bits (112), Expect = 4e-05
Identities = 52/192 (27%), Positives = 74/192 (38%), Gaps = 17/192 (8%)
Query: 439 PSHRQSHQDEETGHGQRGSIKEMSHHPPGHTVVKDRSHLRKDDSEEEKEKEEDPGSHEED 498
PS Q ++ +T H ++ S +E G K R +DS EEK EE PG E
Sbjct: 143 PSDSQVSEEVKTRHSEK-SQREDEEEEEGENYQKGE---RGEDSSEEKHLEE-PG---ET 194
Query: 499 DESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEEEDKEEEEEEEDEERREERAEV 558
+ K +++ E G S + E+ +E EE + +
Sbjct: 195 QNAFLNERKQASAIKKEELVARSETHAAGHSQEKTHSREKSSQESGEETGSQENHPQESK 254
Query: 559 GAPLSPDHSEEEEEEEEGLEEDEPRFTIIPNPLDR----REEAGGASSEEESGEDTGPQD 614
G P S + E EE EE+ E + R T + R R GG+ EE G PQ+
Sbjct: 255 GQPRSQE--ESEEGEEDATSEVDKRRTRPRHHHGRSRPDRSSQGGSLPSEEKGH---PQE 309
Query: 615 AQEYGNYQPGSL 626
E N SL
Sbjct: 310 ESEESNVSMASL 321
Score = 38.1 bits (87), Expect = 0.028
Identities = 46/217 (21%), Positives = 79/217 (36%), Gaps = 33/217 (15%)
Query: 400 KSDEEDFQDEYKTEVPHHHHHRVPREEDEEVSAELGHQAPSHRQSHQDEETGHGQRGSIK 459
K+ +D +D+ TE E+ + L ++H E + G+ G+
Sbjct: 62 KTSRKDVKDKETTE-----------NENTKFEVRLLRDPADASEAH--ESSSRGEAGAPG 108
Query: 460 EMSHHPPGHTVVKDRSHLRKDDSEEEKEKEEDPGSHEEDDESSEQGEKGTHHGSRDQ--E 517
E P K + + +E+ ++P +S E T H + Q +
Sbjct: 109 EEDIQGP----TKADTEKWAEGGGHSRERADEPQWSLYPSDSQVSEEVKTRHSEKSQRED 164
Query: 518 DEEDEEEGHGLSLNQEEEEEEDKEEEEEEEDEERREERAEVGAPLSPDHSEEEEEEEEGL 577
+EE+E E + E+ EE EE E ER + A + E G
Sbjct: 165 EEEEEGENYQKGERGEDSSEEKHLEEPGETQNAFLNERKQASAIKKEELVARSETHAAGH 224
Query: 578 EEDEPRFTIIPNPLDRREEAGGASSEEESGEDTGPQD 614
+++ RE+ S +ESGE+TG Q+
Sbjct: 225 SQEKTH---------SREK-----SSQESGEETGSQE 247
>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
Length = 2400
Score = 71.6 bits (174), Expect = 2e-12
Identities = 119/567 (20%), Positives = 184/567 (32%), Gaps = 63/567 (11%)
Query: 106 HRSQDHKVGD---EGVSGEEVFAEHGGQARGHRGHGSEDTEDSAEHRHHLPSHRSHSHQD 162
+R +D K+G+ + ++ E H + G + E + H+D
Sbjct: 1753 NRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGHED 1812
Query: 163 EDEDEVVSSEHHHHILRHGHRGHDGEDDEGEEEEEEE------------EEEEEASTEYG 210
+ E + G G + + EGE + E E E E EA E
Sbjct: 1813 NLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESE 1872
Query: 211 H-QAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEEDDDDDDDDDDDDDDDDVSIEYRHQ 269
+A G E EDV +G E + + + + + + + E +
Sbjct: 1873 DVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDE 1932
Query: 270 AHRHQGHGIEEDEDVSDGHHHRDPSHR----HRSHEEDDNDDDDVST----EYGHQAHRH 321
E +E + P + EE + +DV +A
Sbjct: 1933 PESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGE 1992
Query: 322 QDHRKEEVEAVSGEHHHHVPDHRHQGHRD----------EEEDEDVSTERWHQGPQHVHH 371
E+VEA E + Q D EE E + +G
Sbjct: 1993 AQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPES 2052
Query: 372 GLVDEEEEEEEITVQFGHYVASHQPRGHKSDEEDFQDEYKTEVPHHHHHRVPREEDEEVS 431
V+ E EEE G + +S++ D Q+ P P E E
Sbjct: 2053 DGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQK 2112
Query: 432 AELGHQAPSHRQSHQDEETGHGQRGSIKEMSHHPPGHTVVKDRSHLRKDDSE--EEKEKE 489
AE G +AP Q E G + E G +D + +SE E +E E
Sbjct: 2113 AE-GIEAPETEGEAQPESEGIEAPEAEGEAQPESEG-VEAQDAEGEAQPESEGIEAQEAE 2170
Query: 490 EDPGSHEEDDESSE-QGEKGTHHGSRDQEDEEDEE--EGHGLSLNQEEEE---------- 536
E+ E E+ E +GE + + E E E G+ + EEE
Sbjct: 2171 EEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVET 2230
Query: 537 -EEDKEEEEEEEDEERREERAEVGAPLSPDHSEEEEEEEEGLEEDEPRFTIIPNPLDRRE 595
E + E + E E E + E++ L SEE E + ED P T P+P
Sbjct: 2231 PEAEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVPEDRP--TPPPSP----- 2283
Query: 596 EAGGASSEEESGEDTGPQD--AQEYGN 620
GG + + G TGP A +GN
Sbjct: 2284 --GGDTPHQRPGSQTGPSSSRASSWGN 2308
Score = 55.1 bits (131), Expect = 2e-07
Identities = 93/470 (19%), Positives = 150/470 (31%), Gaps = 53/470 (11%)
Query: 187 GEDDEGEEEEEE--EEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQ--- 241
GE +GE E + + ST A G G + V +G G ++
Sbjct: 1698 GEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGEDGEGSQRLNRDKD 1757
Query: 242 ---GHEEDDDDDDDDDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVS---DGHHHRDPSH 295
G E D + + + + S +G GI E + GH
Sbjct: 1758 PKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGHEDNLQGE 1817
Query: 296 RHRSHEEDDNDDDDVSTEYGHQAHRHQDHRKEEVEAVSGEHHHHVPDHRHQGHRDE---- 351
++D D +A E VEA E + Q ++
Sbjct: 1818 AAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAP 1877
Query: 352 -------EEDEDVSTERWHQGPQHVHHGLVDEEEEEEEITVQFGHYVASHQPRGHKSDEE 404
E EDV T Q G E E+E A + ++ E
Sbjct: 1878 EAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKE----------AQPETESVEALET 1927
Query: 405 DFQDEYKTEVPHHHHHRVPREEDEEVSAEL-GHQAPSHR--QSHQDEETGHGQRGSIKEM 461
+ +DE ++E +E EE + E G P +S + EE + ++ +
Sbjct: 1928 EGEDEPESE-------GAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEAL 1980
Query: 462 SHHPPGHTVVKDRSHLRKDDSEEEKEKEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEED 521
V + E+ E E G +E +E ++ G + + +E
Sbjct: 1981 EVE-----VETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQ 2035
Query: 522 EEEGHGLSLNQEEEEEEDKEEEEEEEDE--ERREERAEVGAPLSPDHSEEEEEEEEGLEE 579
E EG + + E D E E E+E E E E P+ + + +E EG +
Sbjct: 2036 EVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQ 2095
Query: 580 DEPRFTIIPNPLDRREEAGGASSEEESG----EDTGPQDAQEYGNYQPGS 625
E P ++A G + E G E G + + G QP S
Sbjct: 2096 PESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPES 2145
Score = 43.1 bits (100), Expect = 9e-04
Identities = 51/194 (26%), Positives = 78/194 (40%), Gaps = 24/194 (12%)
Query: 426 EDEEVSAELGHQAPSHRQSH-QDEETGHGQRGSIKEMSHHPPGHTVVKDRSHLRKDDSEE 484
E++ S+ L A + Q Q EET G G + + K L+++ +
Sbjct: 1281 EEQRASSNLEQLAENTVQEEVQLEETKEGTEG--EGLQEEAVQLEETKTEEGLQEEGVQL 1338
Query: 485 EKEKE-EDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEEEDKEEE 543
E+ KE E G EE+ + E E G + E+ +EG L E EE KEE
Sbjct: 1339 EETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEALEEGLKEEG 1398
Query: 544 EEEEDEERREERAEVGAPLSPDHSEEEEEEEEGLEEDEPRFTIIPNPLDRREEAGGASSE 603
EE +E +E +P + +G +ED+P + EEAG AS+
Sbjct: 1399 LPEEGSVHGQELSEASSP-----------DGKGSQEDDP---------VQEEEAGRASAS 1438
Query: 604 EESGEDTGPQDAQE 617
E G ++ E
Sbjct: 1439 AEPCPAEGTEEPTE 1452
Score = 37.7 bits (86), Expect = 0.036
Identities = 37/145 (25%), Positives = 62/145 (42%), Gaps = 14/145 (9%)
Query: 480 DDSEEEKEKEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEEED 539
++ E E++ EE S + EQ + T E+ ++ EG GL + EE
Sbjct: 1272 NEDEAERDSEEQRAS-----SNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETK 1326
Query: 540 KEEEEEEEDEERREERAEVGAPLSPDHSEEEEEEE---EGLEEDEPRFTIIPNPLDRREE 596
EE +EE + E + G + ++ EE EE EGL+E+ + + E
Sbjct: 1327 TEEGLQEEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQL----EEVKEGPE 1382
Query: 597 AG--GASSEEESGEDTGPQDAQEYG 619
G G + EE E+ P++ +G
Sbjct: 1383 GGLQGEALEEGLKEEGLPEEGSVHG 1407
Score = 37.4 bits (85), Expect = 0.048
Identities = 38/157 (24%), Positives = 63/157 (40%), Gaps = 31/157 (19%)
Query: 477 LRKDDSEEEKEKEEDPGSHEEDDES---SEQGEKGTHHGSRDQEDEEDEEEGHG------ 527
L+ + + E PG E + + + + + E E D EE
Sbjct: 1232 LKTSNQRPDSRTYESPGDLENQQQCCFPTFLNARACACATNEDEAERDSEEQRASSNLEQ 1291
Query: 528 LSLNQEEEEEEDKEEEEEEEDEERREERAEVGAPLSPDHSEEEEEEEEGLEEDEPRFTII 587
L+ N +EE + +E +E E E +EE ++ EE + EEGL+E+ +
Sbjct: 1292 LAENTVQEEVQLEETKEGTEGEGLQEEAVQL----------EETKTEEGLQEEGVQ---- 1337
Query: 588 PNPLDRREEAGGASSEEESG-----EDTGPQDAQEYG 619
L+ +E G +EE E+TG + QE G
Sbjct: 1338 ---LEETKETEGEGQQEEEAQLEEIEETGGEGLQEEG 1371
Score = 33.1 bits (74), Expect = 0.90
Identities = 51/220 (23%), Positives = 77/220 (35%), Gaps = 22/220 (10%)
Query: 350 DEEEDEDVSTERWHQGPQHVHHGLVDEEEEEEEITVQFGHYVASHQPRGHKSDEEDFQ-D 408
++E + D +R + + V EE + EE G EE Q +
Sbjct: 1273 EDEAERDSEEQRASSNLEQLAENTVQEEVQLEE---------TKEGTEGEGLQEEAVQLE 1323
Query: 409 EYKTEVPHHHHHRVPREEDEEVSAELGHQAPSHRQSHQDEETG----HGQRGSIKEMSHH 464
E KTE V EE +E E Q Q + EETG + ++E+
Sbjct: 1324 ETKTE-EGLQEEGVQLEETKETEGE--GQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEG 1380
Query: 465 PPGHTVVKDRSHLRKDDSEEEKEKEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEE 524
P G + ++ +EE EE +E E+S KG+ QE+E
Sbjct: 1381 PEGGL----QGEALEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEEEAGRAS 1436
Query: 525 GHGLSLNQEEEEEEDKEEEEEEEDEERREERAEVGAPLSP 564
E EE + E + ER + G+ L P
Sbjct: 1437 ASAEPCPAEGTEEPTEPPSHLSETDPSASER-QSGSQLEP 1475
>gi|155030232 proline, glutamic acid and leucine rich protein 1 [Homo
sapiens]
Length = 1130
Score = 70.9 bits (172), Expect = 4e-12
Identities = 54/158 (34%), Positives = 73/158 (46%), Gaps = 16/158 (10%)
Query: 469 TVVKDRSHLRKDDSEEEKEKEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGL 528
TV+ S +++ EEE+E+EE+ EE+D E+ ++ + ++E+EE EEE
Sbjct: 879 TVININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEE 938
Query: 529 SLNQEEEEEEDKEEEEEEEDEERREERAEVGA---------PLSPDHSEEEEEEEEGLEE 579
EEEEEE+ EEEEEE +E E G P P E + E
Sbjct: 939 EGELEEEEEEEDEEEEEELEEVEDLEFGTAGGEVEEGAPPPPTLPPALPPPESPPKVQPE 998
Query: 580 DEPRFTIIPNPLDRREEAGGASSEEESGEDTGPQDAQE 617
EP P L EE G +EEE G DT P A E
Sbjct: 999 PEPE----PGLLLEVEEPG---TEEERGADTAPTLAPE 1029
Score = 62.4 bits (150), Expect = 1e-09
Identities = 38/107 (35%), Positives = 57/107 (53%), Gaps = 11/107 (10%)
Query: 522 EEEGHGLSLNQEEEEEEDKEEEEEEEDEERREERAEVGAPLSPDHSEEEEEEEEGLEEDE 581
EE+ +++N +EEEE++EEEEEEE+EE EE D EEEE+EEE EE+E
Sbjct: 875 EEDLTVININSSDEEEEEEEEEEEEEEEEEEEEE---------DFEEEEEDEEEYFEEEE 925
Query: 582 PRFTIIPNPLDRREEAGGASSEEESGEDTGPQDAQEYGNYQPGSLCG 628
+ EE G EEE ++ ++ +E + + G+ G
Sbjct: 926 EEEEEFEEEFE--EEEGELEEEEEEEDEEEEEELEEVEDLEFGTAGG 970
Score = 50.4 bits (119), Expect = 5e-06
Identities = 22/77 (28%), Positives = 44/77 (57%)
Query: 186 DGEDDEGEEEEEEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEE 245
D E++E EEEEEEEEEEEE ++ + + EE+E+ + EE
Sbjct: 887 DEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEEEE 946
Query: 246 DDDDDDDDDDDDDDDDV 262
+++D++++++ ++ +D+
Sbjct: 947 EEEDEEEEEELEEVEDL 963
Score = 46.6 bits (109), Expect = 8e-05
Identities = 54/249 (21%), Positives = 93/249 (37%), Gaps = 46/249 (18%)
Query: 342 DHRHQGHRDEEEDEDVSTERWHQGPQHVHHGLVDEEEEEEEITVQFGHYVASHQPRGHKS 401
+ + +EEE+E+ E + + + +EEEEEEE +F + G
Sbjct: 890 EEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEF------EEEEGELE 943
Query: 402 DEEDFQDEYKTEVPHHHHHRVPREEDEEVSAELGHQAPSHRQSHQDEETGHGQRGSIKEM 461
+EE+ +DE EE+EE+ + +D E G G ++E
Sbjct: 944 EEEEEEDE---------------EEEEEL------------EEVEDLEFGTA-GGEVEEG 975
Query: 462 SHHPPGHTVVKDRSHLRKDDSEEEKEKEEDPGSHEEDDESSEQGEKGTHHG--------- 512
+ PP + + + + E E +PG E +E + E+G
Sbjct: 976 APPPP---TLPPALPPPESPPKVQPEPEPEPGLLLEVEEPGTEEERGADTAPTLAPEALP 1032
Query: 513 SRDQEDEEDEEEGHGLSLNQEEEEEEDKEEEEEEEDEERREERAEVGAPLSPDHSEEEEE 572
S+ + + E E G + EEE EE+ E ++ + + E E
Sbjct: 1033 SQGEVEREGESPAAGPPPQELVEEEPSAPPTLLEEETEDGSDKVQPPPETPAEEEMETET 1092
Query: 573 EEEGLEEDE 581
E E L+E E
Sbjct: 1093 EAEALQEKE 1101
Score = 42.0 bits (97), Expect = 0.002
Identities = 65/266 (24%), Positives = 102/266 (38%), Gaps = 58/266 (21%)
Query: 350 DEEEDEDVSTERWHQGPQHVHHGLVDEEEEEEEITVQFGHYVASHQPRGHKSDEEDFQDE 409
DEEE+E+ E + + +EEE+EEE + + +EE+F++E
Sbjct: 887 DEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEE------------EEEEEEEFEEE 934
Query: 410 YKTEVPHHHHHRVPREEDEEVSAELGHQAPSHRQSHQDEETGHGQRGSIKEMSHHPPG-H 468
++ E EEDEE EL + +D E G G ++E + PP
Sbjct: 935 FEEEEGELEEEE--EEEDEEEEEEL--------EEVEDLEFGTAG-GEVEEGAPPPPTLP 983
Query: 469 TVVKDRSHLRKDDSEEEKE-----KEEDPGSHEEDDESS----------EQGE-----KG 508
+ K E E E + E+PG+ EE + QGE +
Sbjct: 984 PALPPPESPPKVQPEPEPEPGLLLEVEEPGTEEERGADTAPTLAPEALPSQGEVEREGES 1043
Query: 509 THHGSRDQEDEEDEEEGHGLSLNQEEEEEEDK---------EEE---EEEEDEERREERA 556
G QE E+E L +E E+ DK EEE E E + + +E+
Sbjct: 1044 PAAGPPPQELVEEEPSAPPTLLEEETEDGSDKVQPPPETPAEEEMETETEAEALQEKEQD 1103
Query: 557 EVGAPLSP--DHSEEEEEEEEGLEED 580
+ A L+ D ++E+ E D
Sbjct: 1104 DTAAMLADFIDCPPDDEKPPPPTEPD 1129
Score = 40.8 bits (94), Expect = 0.004
Identities = 17/72 (23%), Positives = 38/72 (52%)
Query: 194 EEEEEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEEDDDDDDDD 253
+EEEEEEEEEE E + E++E+ + + EE+ + ++++
Sbjct: 887 DEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEEEE 946
Query: 254 DDDDDDDDVSIE 265
+++D++++ +E
Sbjct: 947 EEEDEEEEEELE 958
Score = 40.0 bits (92), Expect = 0.007
Identities = 23/69 (33%), Positives = 32/69 (46%)
Query: 158 HSHQDEDEDEVVSSEHHHHILRHGHRGHDGEDDEGEEEEEEEEEEEEASTEYGHQAHRHR 217
+S +E+E+E E + E+DE E EEEEEEEEE E+ +
Sbjct: 884 NSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELE 943
Query: 218 GHGSEEDED 226
EEDE+
Sbjct: 944 EEEEEEDEE 952
Score = 39.7 bits (91), Expect = 0.010
Identities = 22/69 (31%), Positives = 30/69 (43%)
Query: 140 EDTEDSAEHRHHLPSHRSHSHQDEDEDEVVSSEHHHHILRHGHRGHDGEDDEGEEEEEEE 199
E+ E+ E ++E+EDE E + E+ E EEEEEEE
Sbjct: 890 EEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEEEEEEE 949
Query: 200 EEEEEASTE 208
+EEEE E
Sbjct: 950 DEEEEEELE 958
Score = 39.3 bits (90), Expect = 0.013
Identities = 23/74 (31%), Positives = 34/74 (45%), Gaps = 1/74 (1%)
Query: 157 SHSHQDEDEDEVVSSEHHHHILRHGHRGHDGEDDEGEEEEEEEEE-EEEASTEYGHQAHR 215
S ++E+E+E E + E++ EEEEEEEEE EEE E G
Sbjct: 886 SDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEEE 945
Query: 216 HRGHGSEEDEDVSD 229
EE+E++ +
Sbjct: 946 EEEEDEEEEEELEE 959
Score = 38.9 bits (89), Expect = 0.016
Identities = 22/70 (31%), Positives = 30/70 (42%), Gaps = 1/70 (1%)
Query: 140 EDTEDSAEHRHHLPSHRSHSHQDEDEDEVVSSEHHHHI-LRHGHRGHDGEDDEGEEEEEE 198
E+ E+ E ++EDE+E E +GE +E EEEE+E
Sbjct: 892 EEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEEEEEEEDE 951
Query: 199 EEEEEEASTE 208
EEEEE E
Sbjct: 952 EEEEELEEVE 961
Score = 38.5 bits (88), Expect = 0.021
Identities = 27/99 (27%), Positives = 48/99 (48%), Gaps = 37/99 (37%)
Query: 190 DEGEEEEEEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEEDDDD 249
DE EEEEEEEEEEEE EE+E+ EED ++
Sbjct: 887 DEEEEEEEEEEEEEE-----------------EEEEE-----------------EEDFEE 912
Query: 250 DDDDDDD--DDDDDVSIEYRHQAHRHQGHGIEEDEDVSD 286
+++D+++ +++++ E+ + +G +EE+E+ D
Sbjct: 913 EEEDEEEYFEEEEEEEEEFEEEFEEEEGE-LEEEEEEED 950
Score = 36.2 bits (82), Expect = 0.11
Identities = 20/71 (28%), Positives = 32/71 (45%), Gaps = 6/71 (8%)
Query: 140 EDTEDSAEHRHHLPSHRSHSHQDEDEDEVVSSEHHHHILRHGHRGHDGEDDEGEEEEEEE 199
E+ E+ + + ++E+E+E E G E++E E+EEEEE
Sbjct: 902 EEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEE------EGELEEEEEEEDEEEEE 955
Query: 200 EEEEEASTEYG 210
E EE E+G
Sbjct: 956 ELEEVEDLEFG 966
Score = 34.7 bits (78), Expect = 0.31
Identities = 21/69 (30%), Positives = 30/69 (43%)
Query: 161 QDEDEDEVVSSEHHHHILRHGHRGHDGEDDEGEEEEEEEEEEEEASTEYGHQAHRHRGHG 220
++E+E+E E + ++E EEEEE EEE EE E +
Sbjct: 894 EEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEEEEEEEDEEE 953
Query: 221 SEEDEDVSD 229
EE E+V D
Sbjct: 954 EEELEEVED 962
Score = 34.3 bits (77), Expect = 0.40
Identities = 22/100 (22%), Positives = 38/100 (38%), Gaps = 12/100 (12%)
Query: 281 DEDVSDGHHHRDPSHRHRSHEEDDNDDDDVSTEYGHQAHRHQDHRKEEVEAVSGEHHHHV 340
DE+ + + EED ++++ EY + ++ +EE E GE
Sbjct: 887 DEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGE----- 941
Query: 341 PDHRHQGHRDEEEDEDVSTERWHQGPQHVHHGLVDEEEEE 380
+EEE+ED E + + + G E EE
Sbjct: 942 -------LEEEEEEEDEEEEEELEEVEDLEFGTAGGEVEE 974
Score = 33.5 bits (75), Expect = 0.69
Identities = 24/94 (25%), Positives = 36/94 (38%), Gaps = 11/94 (11%)
Query: 137 HGSEDTEDSAEHRHHLPSHRSHSHQDEDEDEVVSSEHHHHILRHGHRGHDGEDDEGEEEE 196
+ S++ E+ E +D +E+E E+ E++E EE E
Sbjct: 884 NSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEE-----------EEEEEEEFE 932
Query: 197 EEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDG 230
EE EEEE E + EE ED+ G
Sbjct: 933 EEFEEEEGELEEEEEEEDEEEEEELEEVEDLEFG 966
Score = 32.7 bits (73), Expect = 1.2
Identities = 8/66 (12%), Positives = 38/66 (57%)
Query: 244 EEDDDDDDDDDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSHEED 303
EE++++++++++++++++ ++ + + + EE+E+ + + EE+
Sbjct: 888 EEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEEEEE 947
Query: 304 DNDDDD 309
+ D+++
Sbjct: 948 EEDEEE 953
Score = 32.7 bits (73), Expect = 1.2
Identities = 9/66 (13%), Positives = 35/66 (53%)
Query: 244 EEDDDDDDDDDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSHEED 303
EE++++++++++++++++ E + EE+E+ + + EE+
Sbjct: 890 EEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEEEEEEE 949
Query: 304 DNDDDD 309
D ++++
Sbjct: 950 DEEEEE 955
Score = 32.3 bits (72), Expect = 1.5
Identities = 16/94 (17%), Positives = 44/94 (46%), Gaps = 2/94 (2%)
Query: 222 EEDEDVSDGHHHHGPSHRHQGHEEDDDDDDDDDDDDDDDDVSIEYRHQAHRHQGHGIEED 281
EED V + + + EE++++++++++D ++++ E + + EE+
Sbjct: 875 EEDLTVININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEE 934
Query: 282 EDVSDGHHHRDPSHRHRSHEEDDNDDDDVSTEYG 315
+ +G + EE+ + +D+ E+G
Sbjct: 935 FEEEEGELEEEEEEEDEEEEEELEEVEDL--EFG 966
Score = 31.2 bits (69), Expect = 3.4
Identities = 17/81 (20%), Positives = 36/81 (44%)
Query: 302 EDDNDDDDVSTEYGHQAHRHQDHRKEEVEAVSGEHHHHVPDHRHQGHRDEEEDEDVSTER 361
E+D ++++ + ++ +EE E E + + +EEE+E+ E
Sbjct: 875 EEDLTVININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEE 934
Query: 362 WHQGPQHVHHGLVDEEEEEEE 382
+ + + +E+EEEEE
Sbjct: 935 FEEEEGELEEEEEEEDEEEEE 955
Score = 30.4 bits (67), Expect = 5.8
Identities = 21/71 (29%), Positives = 30/71 (42%), Gaps = 5/71 (7%)
Query: 140 EDTEDSAEHRHHLPSHRSHSHQDEDEDEVVSSEHHHHILRHGHRGHDGEDDEGEEEEEEE 199
E+ ED E + ++E+E E E + + E+DE EEEE EE
Sbjct: 905 EEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGEL-----EEEEEEEDEEEEEELEE 959
Query: 200 EEEEEASTEYG 210
E+ E T G
Sbjct: 960 VEDLEFGTAGG 970
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 70.5 bits (171), Expect = 5e-12
Identities = 83/422 (19%), Positives = 164/422 (38%), Gaps = 41/422 (9%)
Query: 188 EDDEGEEEEEEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGH--EE 245
++ + E+E + E+E E Q G E++ V + G +G E+
Sbjct: 50 QEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE---QEGQVREQEGQVREQ 106
Query: 246 DDDDDDDDDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDGHHH-RDPSHRHRSHEEDD 304
+ + + + + E Q +G E++ V + R+ + R E
Sbjct: 107 EGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQV 166
Query: 305 NDDDDVSTEYGHQAHRHQDHRKEEVEAVSGEHHHHVPDHRHQGHRDEEEDEDVSTERWHQ 364
+ + E Q R Q+ + E E GE + + Q E++E + +
Sbjct: 167 REQEGQVREQEGQV-REQEGQVREQEGQMGEQEGQMGEQEEQMG---EQEEQMQKQEEQM 222
Query: 365 GPQHVHHGLVDEEEEEEEITVQFGHYVASHQPRGHKSDEEDFQDEYKTEVPHHHHHRVPR 424
G Q +E+ E+E VQ Q + EE R
Sbjct: 223 GEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQM-----------------R 265
Query: 425 EEDEEVSAELGHQAPSHRQSHQDEETGHGQRGSIKEMSHHPPGHTVVKDRSHLRKDDSEE 484
E++E++ + Q+ Q+E+TG Q ++E ++++ ++ E+
Sbjct: 266 EQEEQMREQEEQMLKQKEQTEQEEQTGE-QEEQMREQEEQ------MREQEEQMREQEEQ 318
Query: 485 EKEKEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEEEDKEEEE 544
+E+EE G EE + EQ E+ ++Q +++E+ G Q++EE+ K+EE+
Sbjct: 319 MREQEEQMGKQEE--QMWEQKEQMWEQ--KEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQ 374
Query: 545 ---EEEDEERREERAEVGAPLSPDHSEEEEEEEEGLEEDEPRFTIIPNPLDRREEAGGAS 601
+EE ++EE+ + E+ E++E + E E + + ++EE G
Sbjct: 375 MRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQEEHMGEQ 434
Query: 602 SE 603
E
Sbjct: 435 KE 436
Score = 60.1 bits (144), Expect = 7e-09
Identities = 75/347 (21%), Positives = 137/347 (39%), Gaps = 31/347 (8%)
Query: 320 RHQDHRKEEVEAVSGEHHHHVPDHRHQGHRDEEE-DEDVSTERWHQGPQHVHHGLVDEEE 378
R Q+ + E E E V + Q E + E R +G G V E+E
Sbjct: 76 REQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQE 135
Query: 379 -----EEEEITVQFGHYVASHQPRGHKSDEEDFQDEYKTEVPHHHHHRVPREEDEEVSAE 433
+E ++ Q G + G ++E E + +V RE++ +V +
Sbjct: 136 GQVREQEGQVREQEGQV---REQEGQVREQEGQVREQEGQVREQEGQ--VREQEGQVREQ 190
Query: 434 LGHQAPSHRQSHQDEETGHGQRGSIKEMSHHPPGHTVVKDRSHLRKDDSEEEKEKEEDPG 493
G Q + EE Q +++ + + +RK + E+ E+EE
Sbjct: 191 EGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQ-----MGEQEEQMRKQE-EQMGEQEEQVQ 244
Query: 494 SHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEEEDKEEEEE---EEDEE 550
EE + E+ + R+QE++ E+E L ++ E+EE E+EE E++E+
Sbjct: 245 KQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQ 304
Query: 551 RREERAEVGAPLSPDHSEEEE--EEEEGLEEDEPRFTIIPNPLDRREEAGGASSEEESGE 608
RE+ ++ +EE+ ++EE + E + + + ++EE G E+ +
Sbjct: 305 MREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQ 364
Query: 609 DTGPQDAQEYGNYQPGSLCGYCSFCNRCTECESCHCDEENMGEHCDQ 655
+ + +E Q + R E E EE MGE +Q
Sbjct: 365 EEQVRKQEEQMRKQEEQM--------RKQE-EQMRKQEEQMGEQKEQ 402
Score = 57.4 bits (137), Expect = 4e-08
Identities = 77/364 (21%), Positives = 138/364 (37%), Gaps = 23/364 (6%)
Query: 265 EYRHQAHRHQGHGIEEDEDVSDGHHH-RDPSHRHRSHEEDDNDDDDVSTEYGHQAHRHQD 323
E Q +G E++ V + R+ + R E + + E Q R Q+
Sbjct: 63 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQV-REQE 121
Query: 324 HRKEEVEAVSGEHHHHVPDHRHQGHRDEEE-DEDVSTERWHQGPQHVHHGLVDEEE---- 378
+ E E E V + Q E + E R +G G V E+E
Sbjct: 122 GQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVR 181
Query: 379 -EEEEITVQFGHYVASHQPRGHKSDEEDFQDEY--KTEVPHHHHHRVPREEDEEVSAELG 435
+E ++ Q G G + ++ Q+E K E R+++E++ +
Sbjct: 182 EQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEE 241
Query: 436 HQAPSHRQSHQDEETGHGQRGSIKEMSHHPPGHTVVKDRSHLRKDDSEEEKEKEEDPGSH 495
Q + EE Q ++E + + + K +E+ E+EE G
Sbjct: 242 QVQKQEEQVQKQEEQMRKQEEQMREQEEQ-----MREQEEQMLKQ--KEQTEQEEQTGEQ 294
Query: 496 EEDDESSEQGEKGTHHGSRDQEDE-EDEEEGHGLSLNQEEEEEEDKEEE-EEEEDEERRE 553
EE E+ + R+QE++ ++EE G QEE+ E KE+ E++E ++E
Sbjct: 295 EEQMREQEEQMREQEEQMREQEEQMREQEEQMG---KQEEQMWEQKEQMWEQKEQMWKQE 351
Query: 554 ERAEVGAPLSPDHSEEEEEEEEGLEEDEPRFTIIPNPLDRREEAGGASSEEESGEDTGPQ 613
E+ E+ ++EE + + E + + ++EE G +E+ GE
Sbjct: 352 EQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMG-EQKEQMGEQKEQM 410
Query: 614 DAQE 617
QE
Sbjct: 411 REQE 414
Score = 43.9 bits (102), Expect = 5e-04
Identities = 60/347 (17%), Positives = 127/347 (36%), Gaps = 29/347 (8%)
Query: 88 REKEDEDVSKEYGHLLPGHRSQDHKVGDEGVSGEEVFAEHGGQARGHRGHGSEDTEDSAE 147
RE+E + V ++ G + R Q+ +V ++ E E GQ R G E E
Sbjct: 111 REQEGQ-VREQEGQV----REQEGQVREQ----EGQVREQEGQVREQEGQVREQEGQVRE 161
Query: 148 HRHHLPSHRSHSHQDEDEDEVVSSEHHHHILRHGHR-GHDGEDDEGEEEEEEEEE-EEEA 205
+ + E + + + G + G GE +E E+EE+ + +EE
Sbjct: 162 QEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQ 221
Query: 206 STEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEEDDDDDDDDDDDDDDDDVSIE 265
E Q + E++E V Q ++++ + ++ + ++ ++
Sbjct: 222 MGEQEEQMRKQEEQMGEQEEQVQK-QEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLK 280
Query: 266 YRHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSHEEDDNDDDDVSTEYGHQAHRHQDHR 325
+ Q + + G +E++ R+ + R EE + ++ + Q ++
Sbjct: 281 QKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQM 340
Query: 326 KEEVEAV------SGEHHHHVPDHRHQGHRDEEEDEDVSTERWHQGPQHVHHGLVDEEEE 379
E+ E + GE + Q + EE+ + Q Q + +EE+
Sbjct: 341 WEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQ-----MRKQEEQ 395
Query: 380 EEEITVQFGHYVASHQPRGHKSDEEDFQDEYKTEVPHHHHHRVPREE 426
E Q G + + ++E+ E K ++ H ++E
Sbjct: 396 MGEQKEQMG------EQKEQMREQEEQMGEQKEQMRKQEEHMGEQKE 436
Score = 31.2 bits (69), Expect = 3.4
Identities = 30/152 (19%), Positives = 66/152 (43%), Gaps = 5/152 (3%)
Query: 470 VVKDRSHLRKDDSEEEKEKEEDPGSHEEDDESSEQ-GEKGTHHGS-RDQEDEEDEEEGHG 527
V ++S ++ E +++ E D ++ + EQ G+ G R+QE + E+EG
Sbjct: 23 VETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVREQEGQVREQEGQVREQEG-- 80
Query: 528 LSLNQEEEEEEDKEEEEEEEDEERREERAEVGAPLSPDHSEEEEEEEEGLEEDEPRFTII 587
+ ++E + ++E + E++ + RE+ +V +E + E+ + E +
Sbjct: 81 -QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVR 139
Query: 588 PNPLDRREEAGGASSEEESGEDTGPQDAQEYG 619
RE+ G +E + Q ++ G
Sbjct: 140 EQEGQVREQEGQVREQEGQVREQEGQVREQEG 171
>gi|121256621 dentin matrix acidic phosphoprotein 1 isoform 2
precursor [Homo sapiens]
Length = 497
Score = 69.7 bits (169), Expect = 9e-12
Identities = 92/471 (19%), Positives = 160/471 (33%), Gaps = 74/471 (15%)
Query: 193 EEEEEEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHH-----GPSHRHQGHEEDD 247
E E+ EE + A A+ ++ +E + H + G R G DD
Sbjct: 26 ESEDSEEWKGHLAQAPTPPLANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDD 85
Query: 248 DDDDDDDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSHEEDDNDD 307
DDD+DD DD D+D G R R ++D+DD
Sbjct: 86 KDDDEDDSGDDTFG-------------------DDDSGPGPKDRQEGGNSRLGSDEDSDD 126
Query: 308 DDVSTEYGHQAHRHQDHRKEEVEAVSGEHHHHVPDHRHQGHRDEEEDEDVSTERWHQGPQ 367
++E A + QD ++ D E+ D E
Sbjct: 127 TIQASE--ESAPQGQDSAQDTTS--------------ESRELDNEDRVDSKPEG------ 164
Query: 368 HVHHGLVDEEEEEEEITVQFGHYVASHQPRGHKSDEEDFQDEYKTEVPHHHHHRVPREED 427
G +E E EE V G S G + D+E Q + +
Sbjct: 165 ----GDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESI-----------RS 209
Query: 428 EEVSAELGHQAPSHRQSHQDEETGHGQRGSIKEMSHHPPGHTVVK-------DRSHLRKD 480
E ++ + ++S ++ E + Q ++ HP K DRS L +
Sbjct: 210 ERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDN 269
Query: 481 DSEEEKEKEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEEEDK 540
++ EE + + S+ D S+ D ++ +EE + E +E
Sbjct: 270 NTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEAN 329
Query: 541 EEEEEEEDEERREERAEVGAPLSPDHSE---EEEEEEEGLEEDEPRFTIIPNPLDRREEA 597
+E E + E +E +PD + E++E+ + EED R E+A
Sbjct: 330 LSSQENSSESQEEVVSESRGD-NPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQA 388
Query: 598 GGASSEEESGEDTGPQDAQEYGNYQPGSLCGYCSFCNRCTECESCHCDEEN 648
SSE + + P+ ++ + L + S ++ E H +E++
Sbjct: 389 DSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAE--SQSEESHSEEDD 437
Score = 68.9 bits (167), Expect = 1e-11
Identities = 116/558 (20%), Positives = 188/558 (33%), Gaps = 131/558 (23%)
Query: 52 EASAELRHHLHSPRDHPDENKDVSTENGHHFWSHPDREKEDEDVSKE---YGHLLPGHRS 108
E S E + HL P N+D S D + +E + + Y + L G S
Sbjct: 28 EDSEEWKGHLAQAPTPPLANEDPS-----------DSTQSEEGLGSDDHQYIYRLAGGFS 76
Query: 109 Q------DHKVGDEGVSGEEVFAEHGGQARGHRGHGSEDTEDSAEHRHHLPSHRSHSHQD 162
+ D K DE SG++ F + G G +D ++ R D
Sbjct: 77 RSTGKGGDDKDDDEDDSGDDTFGDDDS------GPGPKDRQEGGNSR---------LGSD 121
Query: 163 EDEDEVVSSEHHHHILRHGHRGHDGEDDEGEEEEEEEEEEEEASTEYGHQAHRHRGHGSE 222
ED D+ + + +G D D E E + E+ S G G
Sbjct: 122 EDSDDTIQASEES-----APQGQDSAQDTTSESRELDNEDRVDSKPEG---------GDS 167
Query: 223 EDEDVSDGHHHHGPSHRHQGHEEDDDDDDDDDDDDDDDDVSIEYRHQAHRHQGHGIEEDE 282
E S+ H G S H + + DD+ DD + + E + G +E
Sbjct: 168 TQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESG 227
Query: 283 DVSDGHHHRD---------PSHR----HRSHEEDDNDDDDVSTEYGHQAHRHQDHRKEEV 329
+ S+ + +D PS + R EEDD + D ++ EEV
Sbjct: 228 ENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELD------------DNNTMEEV 275
Query: 330 EAVSGEHHHHVPDHRHQGHRDEEED-EDVSTERWHQGPQHVHHGLVDEEEEEEEITVQFG 388
++ S E+ + Q RD + D ++ S E Q G E +E ++ Q
Sbjct: 276 KSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQ-- 333
Query: 389 HYVASHQPRGHKSDEEDFQDEYKTEVPHHHHHRVPREEDEEVSAELGHQAPSHRQSHQDE 448
+E+ E + + P V +ED + S E SH SH
Sbjct: 334 --------ENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEE----DSSHTLSHSKS 381
Query: 449 ETGHGQRGSIKEMSHHPPGHTVVKDRSHLRKDDSEEEKEKEEDPGSHEEDDESSEQGEKG 508
E+ Q S + SE EE P S E+++ SS++G +
Sbjct: 382 ESREEQADS----------------------ESSESLNFSEESPESPEDENSSSQEGLQS 419
Query: 509 THHGSRDQEDEEDEEEGHGLSLNQEEEEEEDKEEEEEEEDEERREERAEVGAPLSPDHSE 568
H S E + E+ EE++ D + E S
Sbjct: 420 --HSS------------------SAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSS 459
Query: 569 EEEEEEEGLEEDEPRFTI 586
EE+ + + +E + + T+
Sbjct: 460 EEDGQLKNIEIESRKLTV 477
Score = 48.9 bits (115), Expect = 2e-05
Identities = 55/245 (22%), Positives = 91/245 (37%), Gaps = 45/245 (18%)
Query: 69 DENKDVSTENGHHFWSHPDREKEDEDVSKEYGHLLPGHRSQDHKVGDEGVSGEEVFAEHG 128
+E K STEN + + + + D G +D K E +S EE G
Sbjct: 273 EEVKSDSTENSNSRDTGLSQPRRDSK----------GDSQEDSK---ENLSQEESQNVDG 319
Query: 129 GQARGHRGHGSEDTEDSAEHRHHLPSHR-------SHSHQDEDEDEVVSSEHHHHILRHG 181
+ + E+S+E + + S + S+ ++ ED S E H L H
Sbjct: 320 PSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHS 379
Query: 182 HRGHDGEDDEGE--------EEEEEEEEEEEASTEYGHQAHR-------HRGHGSEEDED 226
E + E EE E E+E +S++ G Q+H H E+D D
Sbjct: 380 KSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSD 439
Query: 227 VSDGHHHHGPSHRHQGHEEDDDDDDDDDDDDDDDDVSIEYRH---QAHRHQGHGIEEDED 283
D S R + + ++D ++ IE R A+ ++ G ++D D
Sbjct: 440 SQD-------SSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVDAYHNKPIGDQDDND 492
Query: 284 VSDGH 288
DG+
Sbjct: 493 CQDGY 497
Score = 45.1 bits (105), Expect = 2e-04
Identities = 46/195 (23%), Positives = 69/195 (35%), Gaps = 42/195 (21%)
Query: 50 SEEASAELRHHL--HSPRDHPD---------ENKDVSTENGHHFWSHPDREKEDEDVSKE 98
S+E S+E + + S D+PD E+ D S E+ H SH E +E E
Sbjct: 332 SQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSE 391
Query: 99 YGHLLPGHRSQDHKVGDEGVSGEEVFAEHGGQA--RGHRGHGSEDTEDSAEHRHHLPSHR 156
L DE S +E H A + H ED DS +
Sbjct: 392 SSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQD--------S 443
Query: 157 SHSHQDEDEDEVVSSEHHHHILRHGHRGHDGEDDEGEEEEEEEEEEEEASTEYGHQAHRH 216
S S +D + E SS EE+ + + E S + A+ +
Sbjct: 444 SRSKEDSNSTESKSS---------------------SEEDGQLKNIEIESRKLTVDAYHN 482
Query: 217 RGHGSEEDEDVSDGH 231
+ G ++D D DG+
Sbjct: 483 KPIGDQDDNDCQDGY 497
Score = 39.3 bits (90), Expect = 0.013
Identities = 29/98 (29%), Positives = 46/98 (46%), Gaps = 13/98 (13%)
Query: 541 EEEEEEEDEERREERAEVGAP-LSPDHSEEEEEEEEGLEEDEPRFTI-IPNPLDRREEAG 598
+ E E+ EE + A+ P L+ + + + EEGL D+ ++ + R G
Sbjct: 23 QNNESEDSEEWKGHLAQAPTPPLANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKG 82
Query: 599 G---ASSEEESGEDT--------GPQDAQEYGNYQPGS 625
G E++SG+DT GP+D QE GN + GS
Sbjct: 83 GDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGS 120
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 69.7 bits (169), Expect = 9e-12
Identities = 122/592 (20%), Positives = 221/592 (37%), Gaps = 103/592 (17%)
Query: 91 EDEDVSKEYGHLLPGHRSQDHKVGDEGVS------GEEVFAEHGGQARGHRG-------H 137
+++D+ KE L +Q K E V+ EE F + +G +G +
Sbjct: 54 DEDDILKELEEL--SLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDN 111
Query: 138 GSEDTED--SAEHRHHLPSHRSHSHQDEDEDEVVSSEHHHHILRHGHRGHDG-EDDEGEE 194
SE+ ED S + P +S D+D+D + + ++ DG E+DE
Sbjct: 112 DSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNS 171
Query: 195 EEEEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEEDDDDDDDDD 254
++ +E +S E G E DE + S + Q + + + +
Sbjct: 172 KKIKERSRINSSGE----------SGDESDEFLQ--------SRKGQKKNQKNKPGPNIE 213
Query: 255 DDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSHEEDDNDDDDVSTEY 314
++DDD S + + A Q +++ + + + + EE + D S +
Sbjct: 214 SGNEDDDASFKIKTVA---QKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQK 270
Query: 315 GHQAHRHQDHRKEEVEAVSG-----EHHHHVP---------DHRHQGHRDEEEDEDVSTE 360
Q ++ K +V +G E P D + + + ++ +++ +
Sbjct: 271 ESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEK 330
Query: 361 RWHQGPQH-----VHHGLVDEEEEEEEITVQFGHYVASHQPRGHKSDEEDFQDEYKTEVP 415
+GP + L +EEEE + + + K EE+ ++ K E
Sbjct: 331 EKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRE-- 388
Query: 416 HHHHHRVPREEDEEVSAELGHQAPSHRQSHQDEETG----HGQRGSIKEMSHHPPGHTVV 471
+ +E E + E S R++ E Q + P +
Sbjct: 389 --RKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIY 446
Query: 472 KDRSHLRKDDSEEEKE--------------------KEEDPGSHEEDDESSEQGEKGTHH 511
+D+ + E KE KEE P E ++E + + G
Sbjct: 447 EDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTE-DAGLDD 505
Query: 512 GSRDQEDEEDEE-EGHGLSL----NQEEEEEEDKEEEEEEEDEERREERAEVGAPLSPDH 566
DEE E+ EG+ + + N EEEEEE++EEEE+EE EE EE E +
Sbjct: 506 WEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGE------SEG 559
Query: 567 SEEEEEEEEGLEEDEPRFTIIPNPLDRREEAGGASSEEESGEDTGPQDAQEY 618
SE +EE+E+ +E + T LD++ +S E +D ++ + Y
Sbjct: 560 SEGDEEDEKVSDEKDSGKT-----LDKKPSKEMSSDSEYDSDDDRTKEERAY 606
Score = 58.2 bits (139), Expect = 3e-08
Identities = 77/415 (18%), Positives = 166/415 (40%), Gaps = 46/415 (11%)
Query: 192 GEEEEEEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEEDDDDDD 251
G++++ + E+ + + A G G+ ++++ S + E+ D D
Sbjct: 2 GKKQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQK-------SKGKKKKEKKKQDFD 54
Query: 252 DDDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSHEEDDNDDDDVS 311
+DD + +++S+E + + ++ E+ + +D + + ++ DD+D S
Sbjct: 55 EDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDND-S 113
Query: 312 TEYGHQAHRHQDHRKEEVEAVSGEHHHHVPDHRHQGHRDEEEDEDVSTERWHQGPQHVHH 371
E + + + K +VE SG D ++ + + S ++W
Sbjct: 114 EELEDKDSKSKKTAKPKVEMYSGSDDD---DDFNKLPKKAKGKAQKSNKKWDGS------ 164
Query: 372 GLVDEEEEEEEITVQFGHYVASHQPRGHKSDEEDFQDEYKTEVPHHHHHRVPR----EED 427
EE+E+ ++ + S G +SDE F K + + + P ED
Sbjct: 165 ----EEDEDNSKKIKERSRINSSGESGDESDE--FLQSRKGQKKNQKNKPGPNIESGNED 218
Query: 428 EEVSAELGHQAPSHRQSHQDEETGHGQ-RGSIKEMSHHPPGHTVVKDRSHLRKDDS--EE 484
++ S ++ A + + E + + ++++ T KD+S ++ EE
Sbjct: 219 DDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEE 278
Query: 485 E----------------KEKEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGL 528
E +EK E P + E+D+E ++ + +E E+++++G
Sbjct: 279 ETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSK 338
Query: 529 SLNQEEEEEEDKEEEEEEEDEERREERAEVGAPLSPDHSEEEEEEEEGLEEDEPR 583
+ + +E K +EEEE + EER + L EEE E+E E + +
Sbjct: 339 ATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQK 393
Score = 52.8 bits (125), Expect = 1e-06
Identities = 40/146 (27%), Positives = 63/146 (43%), Gaps = 16/146 (10%)
Query: 140 EDTEDSAEHRHHLPSHRSHSHQDEDEDEVVSSEHHHHILRHGHRGHDGEDDEGEEEEEEE 199
EDTED+ + DE+ ++V ++ H + + +E EEEEEEE
Sbjct: 496 EDTEDAGLDDWEAMA------SDEETEKVEGNKVHIEVKEN--------PEEEEEEEEEE 541
Query: 200 EEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEEDDDDDDDDDDDDDD 259
EE+EE+ E + G EEDE VSD + E D + D DDD
Sbjct: 542 EEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTK 601
Query: 260 DDVSIEYRHQAHRHQGHGIEEDEDVS 285
++ + Y R + +E ++V+
Sbjct: 602 EERA--YDKAKRRIEKRRLEHSKNVN 625
Score = 50.4 bits (119), Expect = 5e-06
Identities = 38/151 (25%), Positives = 66/151 (43%), Gaps = 22/151 (14%)
Query: 195 EEEEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEEDDDDDDDDD 254
E EEEE+ E+A + S+E+ + +G+ H + EE++++++++D
Sbjct: 491 EPEEEEDTEDAGLD------DWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEED 544
Query: 255 DDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDGHH-----HRDPSHRHRSHEEDDNDDDD 309
++ ++++ + G EEDE VSD + PS S E D+DDD
Sbjct: 545 EESEEEE-----EEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDR 599
Query: 310 VSTEYGHQAHRHQDHRKEEVEAVSGEHHHHV 340
E R D K +E EH +V
Sbjct: 600 TKEE------RAYDKAKRRIEKRRLEHSKNV 624
Score = 39.3 bits (90), Expect = 0.013
Identities = 83/487 (17%), Positives = 173/487 (35%), Gaps = 58/487 (11%)
Query: 87 DREKEDEDVSKEYGHLLPGHRSQDHKVGDEGVSGEEVFAEHGGQARGHRGH-------GS 139
D +EDED SK+ RS+ + G+ G +E GQ + + G+
Sbjct: 162 DGSEEDEDNSKKIKE-----RSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGN 216
Query: 140 EDTEDSAEHRHHLPSHRSHSHQDEDEDEVVSSEHHHHILRHGHRGHDGEDDEGEEEEEEE 199
ED D A + + + ++ + + + L+ G+ D+ +++E +
Sbjct: 217 ED--DDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQR 274
Query: 200 EEEEEA-----STEYGH-QAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEEDDDDDDDD 253
+ EEE + + G A + ED ++G + +G +E+ + +
Sbjct: 275 KFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKK 334
Query: 254 DDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSHEEDDNDDDDVSTE 313
+++ +A ++E+E+ R+ R + EE + +
Sbjct: 335 GPSK----ATVKAMQEALAK----LKEEEE----RQKREEEERIKRLEELEAKRKEEERL 382
Query: 314 YGHQAHRHQDHRKEEVEAVSGEHHHHVPDHRHQGHRDEE-----EDEDVSTERWHQGPQH 368
+ R + KE E + E R R E + + V P+
Sbjct: 383 EQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKK 442
Query: 369 VHHGLVDEEEEEEEITVQFGHYVASHQPR---GHKSDEEDFQDEYKTEVPHHHHHRVPRE 425
+ E+++ ++I Q S + E+ ++ +T P P E
Sbjct: 443 RP---IYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVE-----PEE 494
Query: 426 EDEEVSAELGHQAPSHRQSHQDEETGHGQRGSIKEMSHHPPGHTVVKDRSHLRKDDSEEE 485
E++ A L ++ G+ +KE ++ +++ EEE
Sbjct: 495 EEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEE 554
Query: 486 KEKEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEEEDKEEEEE 545
E E G E++ S E +D D++ +S + E + ++D+ +EE
Sbjct: 555 GESEGSEGDEEDEKVSDE----------KDSGKTLDKKPSKEMSSDSEYDSDDDRTKEER 604
Query: 546 EEDEERR 552
D+ +R
Sbjct: 605 AYDKAKR 611
>gi|17975763 myelin transcription factor 1 [Homo sapiens]
Length = 1121
Score = 68.9 bits (167), Expect = 1e-11
Identities = 52/162 (32%), Positives = 79/162 (48%), Gaps = 17/162 (10%)
Query: 466 PGHTVVKDRSHLRKDDSEEEKEKEEDPGSHEEDDESSEQGEKGTHHGS----RDQEDEED 521
PG +V HL ++ +E +E + G + +++ E E T + ED
Sbjct: 190 PGPGIV----HLLQEAAEGAASEEGEKGLFIQPEDAEEVVEVTTERSQDLCPQSLEDAAS 245
Query: 522 EEEGH--GLSLNQEEEEEEDKEEEEEEEDEERREERAEVGAPLSPDHSEEEEEEEEGLEE 579
EE G+ ++EE+EEE++EEEEEEEDEE EE E + EEEEEEEE EE
Sbjct: 246 EESSKQKGILSHEEEDEEEEEEEEEEEEDEEEEEEEEE-----EEEEEEEEEEEEEEEEE 300
Query: 580 DEPRFTIIPNPLDRREEAGGASSEEESGEDTGPQDAQEYGNY 621
+E P+ + +E +S +++ E GP+ Y
Sbjct: 301 EEEEEEAAPDVI--FQEDTSHTSAQKAPELRGPESPSPKPEY 340
Score = 53.1 bits (126), Expect = 8e-07
Identities = 37/135 (27%), Positives = 54/135 (40%), Gaps = 20/135 (14%)
Query: 121 EEVFAEHGGQARGHRGHGSEDTEDSAEHRHHLPSHRSHSHQDEDEDEVVSSEHHHHILRH 180
E+ +E + +G H ED E+ E ++E+E+E
Sbjct: 241 EDAASEESSKQKGILSHEEEDEEEEEEEEEEEEDEEEEEEEEEEEEE------------- 287
Query: 181 GHRGHDGEDDEGEEEEEEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRH 240
+ E++E EEEEEEEEEEEEA+ + Q H S + G P +
Sbjct: 288 -----EEEEEEEEEEEEEEEEEEEAAPDVIFQ--EDTSHTSAQKAPELRGPESPSPKPEY 340
Query: 241 QGHEEDDDDDDDDDD 255
E DDD D+D
Sbjct: 341 SVIVEVRSDDDKDED 355
Score = 48.5 bits (114), Expect = 2e-05
Identities = 30/111 (27%), Positives = 53/111 (47%), Gaps = 4/111 (3%)
Query: 475 SHLRKDDSEEEKEKEEDPGSHEEDDESSEQGEKGTHHGSRDQEDE-EDEEEGHGLSLNQE 533
SH +D+ EEE+E+EE+ EE++E E+ E+ ++E+E E+EEE + QE
Sbjct: 256 SHEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEAAPDVIFQE 315
Query: 534 EEEEEDKEEEEE---EEDEERREERAEVGAPLSPDHSEEEEEEEEGLEEDE 581
+ ++ E E + E + + S D +E+ + DE
Sbjct: 316 DTSHTSAQKAPELRGPESPSPKPEYSVIVEVRSDDDKDEDTHSRKSTVTDE 366
Score = 40.8 bits (94), Expect = 0.004
Identities = 56/263 (21%), Positives = 92/263 (34%), Gaps = 30/263 (11%)
Query: 55 AELRHHLHSPRDHP-----DENKDVSTENGHHFWSHPDREKEDEDVSKEYGHLLPGHRS- 108
AE H + + HP DE V ++ D E +D VS E L G +
Sbjct: 65 AEAEHLVSKRKSHPLKLALDEGYGVDSDGSE------DTEVKDASVSDESEGTLEGAEAE 118
Query: 109 ---QDHKVGDEGVSGEEVFAEH------GGQARGHRGHGSEDTEDSAEHRHHLPSHRSHS 159
QD E G H G +G S A +L +
Sbjct: 119 TSGQDEIHRPETAEGRSPVKSHFGSNPIGSATASSKGSYSSYQGIIATSLLNLGQIAEET 178
Query: 160 HQDEDEDEVVS-SEHHHHILRHGHRGHDGEDDEGEE----EEEEEEEEEEASTEYGHQA- 213
+ED + H+L+ G E EGE+ + E+ EE E +TE
Sbjct: 179 LVEEDLGQAAKPGPGIVHLLQEAAEGAASE--EGEKGLFIQPEDAEEVVEVTTERSQDLC 236
Query: 214 -HRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEEDDDDDDDDDDDDDDDDVSIEYRHQAHR 272
SEE H + EE++++D+++++++++++ E +
Sbjct: 237 PQSLEDAASEESSKQKGILSHEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEEEEEEEEEE 296
Query: 273 HQGHGIEEDEDVSDGHHHRDPSH 295
+ EE+E D D SH
Sbjct: 297 EEEEEEEEEEAAPDVIFQEDTSH 319
Score = 36.6 bits (83), Expect = 0.081
Identities = 39/176 (22%), Positives = 66/176 (37%), Gaps = 25/176 (14%)
Query: 350 DEEEDEDVSTERWHQ-GPQHVHHGLVDEEEEEEEITVQFGHYVASHQPRGHKSDEEDFQD 408
D EE +V+TER PQ + E+ EE + Q G + SH+ + +EE+ ++
Sbjct: 220 DAEEVVEVTTERSQDLCPQSL------EDAASEESSKQKG--ILSHEEEDEEEEEEEEEE 271
Query: 409 EYKTEVPHHHHHRVPREEDEEVSAELGHQAPSHRQSHQDEETGHGQRGSIKEMSHHPPGH 468
E EE+EE E + + ++EE + + + H
Sbjct: 272 EED------------EEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEAAPDVIFQEDTSH 319
Query: 469 TVVKDRSHLRKDDSEEEKEKEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEE 524
T + LR +S K + DD+ E TH DE + ++
Sbjct: 320 TSAQKAPELRGPESPSPKPEYSVIVEVRSDDDKDED----THSRKSTVTDESEMQD 371
Score = 35.0 bits (79), Expect = 0.24
Identities = 27/129 (20%), Positives = 52/129 (40%), Gaps = 7/129 (5%)
Query: 422 VPREEDEEVSAELGHQAPSHRQSHQDEETGHGQRGSIKEMSHHPPGHTVVKDRSHLRKDD 481
V E +++ + A S S Q H + +E ++ +++
Sbjct: 227 VTTERSQDLCPQSLEDAASEESSKQKGILSHEEEDEEEEEEEEEEEEDEEEEEEEEEEEE 286
Query: 482 SEEEKEKEEDPGSHEEDDESSEQG---EKGTHHGSRDQEDE----EDEEEGHGLSLNQEE 534
EEE+E+EE+ EE++E + ++ T H S + E E S+ E
Sbjct: 287 EEEEEEEEEEEEEEEEEEEEAAPDVIFQEDTSHTSAQKAPELRGPESPSPKPEYSVIVEV 346
Query: 535 EEEEDKEEE 543
++DK+E+
Sbjct: 347 RSDDDKDED 355
Score = 35.0 bits (79), Expect = 0.24
Identities = 21/80 (26%), Positives = 34/80 (42%), Gaps = 14/80 (17%)
Query: 303 DDNDDDDVSTEYGHQAHRHQDHRKEEVEAVSGEHHHHVPDHRHQGHRDEEEDEDVSTERW 362
+D ++ S + G +H +D +EE E E + + +EEE+E+ E
Sbjct: 241 EDAASEESSKQKGILSHEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEE-- 298
Query: 363 HQGPQHVHHGLVDEEEEEEE 382
+EEEEEEE
Sbjct: 299 ------------EEEEEEEE 306
Score = 32.7 bits (73), Expect = 1.2
Identities = 22/83 (26%), Positives = 34/83 (40%), Gaps = 2/83 (2%)
Query: 302 EDDNDDDDVSTEYGHQA--HRHQDHRKEEVEAVSGEHHHHVPDHRHQGHRDEEEDEDVST 359
ED + +V+TE +D EE G H D + +EEE+++
Sbjct: 219 EDAEEVVEVTTERSQDLCPQSLEDAASEESSKQKGILSHEEEDEEEEEEEEEEEEDEEEE 278
Query: 360 ERWHQGPQHVHHGLVDEEEEEEE 382
E + + +EEEEEEE
Sbjct: 279 EEEEEEEEEEEEEEEEEEEEEEE 301
>gi|100816397 MYST histone acetyltransferase (monocytic leukemia) 4
[Homo sapiens]
Length = 2073
Score = 68.9 bits (167), Expect = 1e-11
Identities = 107/418 (25%), Positives = 156/418 (37%), Gaps = 62/418 (14%)
Query: 188 EDDEGEEEEEEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEEDD 247
E E EEEEE+EEEEEE E EEDE+ + + EE++
Sbjct: 1067 ESSEEEEEEEDEEEEEEEEEE-------------EEDEEEEE---------EEEEEEEEE 1104
Query: 248 DDDDDDDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSHEEDDNDD 307
+ V+I+ + + G + S +E DN D
Sbjct: 1105 NIQSSPPRLTKPQSVAIKRKRPFVLKKKRGRKRRRINSSVTTETISETTEVLNEPFDNSD 1164
Query: 308 DD---VSTEYGHQAHRHQDHRKEEVEAVSGEHHHHVPDHRHQGHRDEEEDE------DVS 358
++ E + +D RK V + H P + Q +E +D D
Sbjct: 1165 EERPMPQLEPTCEIEVEEDGRKP----VLRKAFQHQPGKKRQTEEEEGKDNHCFKNADPC 1220
Query: 359 TERWHQGPQHVHHGLVDEEEEEEEITV-QFGHYVASHQPRGHKSDEEDFQDEYKT--EVP 415
+ ++ G D E + V G + R +K + F+ T E P
Sbjct: 1221 RNNMNDDSSNLKEGSKDNPEPLKCKQVWPKGTKRGLSKWRQNKERKTGFKLNLYTPPETP 1280
Query: 416 HHHHHRVPREEDEEVSAELGHQAPSH-RQSHQDEETGHG---QRGSIKEMSHHP------ 465
+V EE +E S G +PS R + +ETG Q + +E + P
Sbjct: 1281 MEPDEQVTVEEQKETSE--GKTSPSPIRIEEEVKETGEALLPQEENRREETCAPVSPNTS 1338
Query: 466 PGHTVVKDRSHLRKDDSEEEKEKEEDPGSHEEDDESSEQG---EKGTHHGSRDQEDEEDE 522
PG K L K + EEE+E+EE+ EE+ E E G EK G++ QE EE E
Sbjct: 1339 PGE---KPEDDLIKPEEEEEEEEEEEEEEEEEEGEEEEGGGNVEKDPD-GAKSQEKEEPE 1394
Query: 523 EEGHGLSLNQEEEEEEDKEEEEEEEDEERREERAEVGAPLSPDHSEEEEEEEEGLEED 580
+S +E+ D EEEEEEDEE H E E E+E L +
Sbjct: 1395 -----ISTEKEDSARLDDHEEEEEEDEEPSHNEDHDADDEDDSHMESAEVEKEELPRE 1447
Score = 61.2 bits (147), Expect = 3e-09
Identities = 79/378 (20%), Positives = 145/378 (38%), Gaps = 55/378 (14%)
Query: 279 EEDEDVSDGHHHRDPSHRHRSHEEDDNDDDDVSTEYGHQAHRHQDHRKEEVEAVSGEHHH 338
EE+E+ D + EED+ ++++ E + + R + ++V+ +
Sbjct: 1070 EEEEEEED----EEEEEEEEEEEEDEEEEEEEEEEEEEENIQSSPPRLTKPQSVAIKRKR 1125
Query: 339 HVPDHRHQGHRDEEEDEDVSTERWHQGPQHVHHGLVDEEEE--------------EEEIT 384
+ +G + + V+TE + + ++ + +EE EE+
Sbjct: 1126 PFVLKKKRGRKRRRINSSVTTETISETTEVLNEPFDNSDEERPMPQLEPTCEIEVEEDGR 1185
Query: 385 VQFGHYVASHQP-RGHKSDEEDFQDE--YKTEVPHHHHHRVPREEDEEVSAELGHQAPSH 441
HQP + +++EE+ +D +K P ++ +E S +
Sbjct: 1186 KPVLRKAFQHQPGKKRQTEEEEGKDNHCFKNADPCRNNMNDDSSNLKEGSKDNPEPLKCK 1245
Query: 442 RQSHQDEETGHGQRGSIKE------MSHHPPGHTVVKDRSHLRKDDSEEEKEKEEDPGSH 495
+ + + G + KE ++ + P T ++ + ++ +E E + P
Sbjct: 1246 QVWPKGTKRGLSKWRQNKERKTGFKLNLYTPPETPMEPDEQVTVEEQKETSEGKTSPSPI 1305
Query: 496 EEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLN-------------QEEEEEEDKEE 542
++E E GE QE+ EE +S N EEEEEE++EE
Sbjct: 1306 RIEEEVKETGE-----ALLPQEENRREETCAPVSPNTSPGEKPEDDLIKPEEEEEEEEEE 1360
Query: 543 EEEEEDEERREERAEVGAPLSPDHSEEEEEEEEGL---EEDEPRFTIIPNPLDRREEAGG 599
EEEEE+EE EE PD ++ +E+EE + +ED R LD EE
Sbjct: 1361 EEEEEEEEGEEEEGGGNVEKDPDGAKSQEKEEPEISTEKEDSAR-------LDDHEEEEE 1413
Query: 600 ASSEEESGEDTGPQDAQE 617
E ED D +
Sbjct: 1414 EDEEPSHNEDHDADDEDD 1431
Score = 55.8 bits (133), Expect = 1e-07
Identities = 37/114 (32%), Positives = 52/114 (45%), Gaps = 5/114 (4%)
Query: 472 KDRSHLRKDDSEEEKEKEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLN 531
K+ L + S EKE++E + +S + + + + E G L L+
Sbjct: 1006 KEAERLMEQASCWEKEEQEILSTRANSRQSPAKVQSKNKYLHSPESRPVTGERGQLLELS 1065
Query: 532 QEEEEEEDKEEEEEEEDEERREERAEVGAPLSPDHSEEEEEEEEGLEEDEPRFT 585
+E EEE EEEEDEE EE E + EEEEEEEE ++ PR T
Sbjct: 1066 KESSEEE-----EEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEENIQSSPPRLT 1114
Score = 54.3 bits (129), Expect = 4e-07
Identities = 102/503 (20%), Positives = 182/503 (36%), Gaps = 103/503 (20%)
Query: 154 SHRSHSHQDEDEDEVVSSEHHHHILRHGHRGHDGEDDEGEEEEEEEEEEEEAST------ 207
S S ++E+EDE E + E++E EEEEEEEEE ++S
Sbjct: 1065 SKESSEEEEEEEDEEEEEEEEEE--------EEDEEEEEEEEEEEEEENIQSSPPRLTKP 1116
Query: 208 -------------EYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEEDDDDDDDDD 254
+ R R + S E +S+ + E +
Sbjct: 1117 QSVAIKRKRPFVLKKKRGRKRRRINSSVTTETISETTEVLNEPFDNSDEERPMPQLEPTC 1176
Query: 255 DDDDDDDVSIEYRHQAHRHQGHGIE--EDEDVSDGH--HHRDPSHRHRSHE-----EDDN 305
+ + ++D +A +HQ E+E+ D H + DP + + + E
Sbjct: 1177 EIEVEEDGRKPVLRKAFQHQPGKKRQTEEEEGKDNHCFKNADPCRNNMNDDSSNLKEGSK 1236
Query: 306 DDDDV---------STEYGHQAHRHQDHRKE--EVEAVSGEHHHHVPDHRHQGHRDEEED 354
D+ + T+ G R RK ++ + PD + +E
Sbjct: 1237 DNPEPLKCKQVWPKGTKRGLSKWRQNKERKTGFKLNLYTPPETPMEPDEQVTVEEQKETS 1296
Query: 355 EDVSTE---RWHQGPQHVHHGLVDEEEEEEEITVQFGHYVASHQPRGHKSDEEDFQDEYK 411
E ++ R + + L+ +EE E T V+ + G K +++ +
Sbjct: 1297 EGKTSPSPIRIEEEVKETGEALLPQEENRREETCA---PVSPNTSPGEKPEDDLIK---- 1349
Query: 412 TEVPHHHHHRVPREEDEEVSAELGHQAPSHRQSHQDEETGHGQRGSIKEMSHHPPGHTVV 471
P EE+EE E + ++EE G + G G V
Sbjct: 1350 -----------PEEEEEEEEEE---------EEEEEEEEGEEEEG----------GGNVE 1379
Query: 472 KDRSHLRKDDSEEEK--EKEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLS 529
KD + + EE + ++ED ++ +E E+ E+ +H+ D +DE+D
Sbjct: 1380 KDPDGAKSQEKEEPEISTEKEDSARLDDHEEEEEEDEEPSHNEDHDADDEDDSH------ 1433
Query: 530 LNQEEEEEEDKEEEEEEEDEERREERAEVGAPLSPDHSEEEEEEEEGLEEDEPRFTIIPN 589
+ E E+E+ E +E E +E ++ + P HS E + G++ T N
Sbjct: 1434 MESAEVEKEELPRESFKEVLENQETFLDLN--VQPGHSNPEVLMDCGVD-----LTASCN 1486
Query: 590 PLDRREEAGGASSEEESGEDTGP 612
+ +E AG + ES E+ P
Sbjct: 1487 S-EPKELAGDPEAVPESDEEPPP 1508
Score = 53.9 bits (128), Expect = 5e-07
Identities = 82/324 (25%), Positives = 119/324 (36%), Gaps = 67/324 (20%)
Query: 278 IEEDEDVSDGHHHRDPSHRHRSHEEDDNDDDDVSTEYGHQAHRHQDHRKEE----VEAVS 333
+EE ++ S+G P R EE E G +++R+EE V +
Sbjct: 1289 VEEQKETSEGKTSPSPI---RIEEE--------VKETGEALLPQEENRREETCAPVSPNT 1337
Query: 334 GEHHHHVPDHRHQGHRDEEEDEDVSTERWHQGPQHVHHGLVDEEEEEEEITVQFGHYVAS 393
D +EEE+E+ +EEEEEEE + G
Sbjct: 1338 SPGEKPEDDLIKPEEEEEEEEEE------------------EEEEEEEEGEEEEGGGNVE 1379
Query: 394 HQPRGHKSDEEDFQDEYKTEVPHH---HHHRVPREEDEEVSAELGHQAPSHRQSHQDE-- 448
P G KS E++ + E TE H EEDEE S H A SH +
Sbjct: 1380 KDPDGAKSQEKE-EPEISTEKEDSARLDDHEEEEEEDEEPSHNEDHDADDEDDSHMESAE 1438
Query: 449 -ETGHGQRGSIKEMSHH---------PPGHT---VVKDRS-HLRKDDSEEEKEKEEDPGS 494
E R S KE+ + PGH+ V+ D L + E KE DP +
Sbjct: 1439 VEKEELPRESFKEVLENQETFLDLNVQPGHSNPEVLMDCGVDLTASCNSEPKELAGDPEA 1498
Query: 495 HEEDDESSEQGEKGTHHGSRDQEDEEDE-EEGHGL-------------SLNQEEEEEEDK 540
E DE GE+ ++ ++ + E +EG+ SL QE E++D
Sbjct: 1499 VPESDEEPPPGEQAQKQDQKNSKEVDTEFKEGNPATMEIDSETVQAVQSLTQESSEQDDT 1558
Query: 541 EEEEEEEDEERREERAEVGAPLSP 564
++ E E R + A SP
Sbjct: 1559 FQDCAETQEACRSLQNYTRADQSP 1582
Score = 47.8 bits (112), Expect = 4e-05
Identities = 34/104 (32%), Positives = 48/104 (46%), Gaps = 35/104 (33%)
Query: 463 HHPPGHTVVKDRSHL---RKDDSEEEKEKEEDPGSHEEDDESSEQGEKGTHHGSRDQEDE 519
H P V +R L K+ SEEE+E+E D+E+E
Sbjct: 1047 HSPESRPVTGERGQLLELSKESSEEEEEEE-------------------------DEEEE 1081
Query: 520 EDEEEGHGLSLNQEEEEEEDKEEEEEEEDEERREERAEVGAPLS 563
E+EEE +EE+EEE++EEEEEEE+E + + P S
Sbjct: 1082 EEEEE-------EEEDEEEEEEEEEEEEEENIQSSPPRLTKPQS 1118
Score = 34.7 bits (78), Expect = 0.31
Identities = 31/125 (24%), Positives = 50/125 (40%), Gaps = 23/125 (18%)
Query: 89 EKEDEDVSKEYGHLLPGHRSQDHKVGDEGVSGEEVFAEHGG-----QARGHRGHGSEDTE 143
EK ++D+ K P ++ + +E EE E GG G + E+ E
Sbjct: 1341 EKPEDDLIK------PEEEEEEEEEEEEEEEEEEGEEEEGGGNVEKDPDGAKSQEKEEPE 1394
Query: 144 DSAEHRHHLPSHRSHSHQDEDEDEVVSSEHHHHILRHGHRGHDGEDDEGEEEEEEEEEEE 203
S E S R H++E+E++ S + H D +D++ E E E+E
Sbjct: 1395 ISTEKED---SARLDDHEEEEEEDEEPSHNEDH---------DADDEDDSHMESAEVEKE 1442
Query: 204 EASTE 208
E E
Sbjct: 1443 ELPRE 1447
Score = 34.3 bits (77), Expect = 0.40
Identities = 24/88 (27%), Positives = 43/88 (48%), Gaps = 7/88 (7%)
Query: 424 REEDEEVSAELG-HQAPSHRQS-----HQDEETG-HGQRGSIKEMSHHPPGHTVVKDRSH 476
+EE E +S Q+P+ QS H E G+RG + E+S ++
Sbjct: 1020 KEEQEILSTRANSRQSPAKVQSKNKYLHSPESRPVTGERGQLLELSKESSEEEEEEEDEE 1079
Query: 477 LRKDDSEEEKEKEEDPGSHEEDDESSEQ 504
+++ EEE+++EE+ EE++E + Q
Sbjct: 1080 EEEEEEEEEEDEEEEEEEEEEEEEENIQ 1107
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.307 0.129 0.393
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,385,198
Number of Sequences: 37866
Number of extensions: 2604529
Number of successful extensions: 95231
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1228
Number of HSP's successfully gapped in prelim test: 902
Number of HSP's that attempted gapping in prelim test: 16467
Number of HSP's gapped (non-prelim): 27562
length of query: 699
length of database: 18,247,518
effective HSP length: 109
effective length of query: 590
effective length of database: 14,120,124
effective search space: 8330873160
effective search space used: 8330873160
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.