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Search of human proteins with 4504111
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4504111 growth factor receptor-bound protein 2 isoform 1
[Homo sapiens]
(217 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Hom... 459 e-129
gi|45359859 growth factor receptor-bound protein 2 isoform 2 [Ho... 357 4e-99
gi|5729856 GRB2-related adaptor protein [Homo sapiens] 281 3e-76
gi|4758476 GRB2-related adaptor protein 2 [Homo sapiens] 170 1e-42
gi|193220941 hypothetical protein LOC400581 [Homo sapiens] 144 7e-35
gi|5453754 NCK adaptor protein 1 [Homo sapiens] 100 9e-22
gi|187475373 c-src tyrosine kinase [Homo sapiens] 99 4e-21
gi|4758078 c-src tyrosine kinase [Homo sapiens] 99 4e-21
gi|4503787 fyn-related kinase [Homo sapiens] 97 1e-20
gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 96 3e-20
gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 96 3e-20
gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo sapi... 96 3e-20
gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens] 95 4e-20
gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens] 95 4e-20
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 94 9e-20
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 94 9e-20
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 93 2e-19
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 93 2e-19
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 93 2e-19
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 93 2e-19
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 93 2e-19
gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens] 92 4e-19
gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2 [... 92 4e-19
gi|112789548 lymphocyte-specific protein tyrosine kinase precurs... 90 1e-18
gi|112789546 lymphocyte-specific protein tyrosine kinase precurs... 90 1e-18
gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens] 90 1e-18
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens] 90 1e-18
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap... 90 2e-18
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi... 90 2e-18
gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens] 90 2e-18
>gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Homo
sapiens]
Length = 217
Score = 459 bits (1180), Expect = e-129
Identities = 217/217 (100%), Positives = 217/217 (100%)
Query: 1 MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW 60
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
Sbjct: 1 MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW 60
Query: 61 FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL 120
FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL
Sbjct: 61 FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL 120
Query: 121 WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG 180
WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG
Sbjct: 121 WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG 180
Query: 181 DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV 217
DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
Sbjct: 181 DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV 217
>gi|45359859 growth factor receptor-bound protein 2 isoform 2 [Homo
sapiens]
Length = 176
Score = 357 bits (916), Expect = 4e-99
Identities = 176/217 (81%), Positives = 176/217 (81%), Gaps = 41/217 (18%)
Query: 1 MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW 60
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHP
Sbjct: 1 MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHP- 59
Query: 61 FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL 120
FGNDVQHFKVLRDGAGKYFL
Sbjct: 60 ----------------------------------------FGNDVQHFKVLRDGAGKYFL 79
Query: 121 WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG 180
WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG
Sbjct: 80 WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG 139
Query: 181 DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV 217
DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
Sbjct: 140 DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV 176
>gi|5729856 GRB2-related adaptor protein [Homo sapiens]
Length = 217
Score = 281 bits (719), Expect = 3e-76
Identities = 129/216 (59%), Positives = 168/216 (77%), Gaps = 2/216 (0%)
Query: 1 MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW 60
ME++A Y F+AT DEL+F +GD LK+LN E DQNWYKAEL G +GFIPKNYI +KPHPW
Sbjct: 1 MESVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIRVKPHPW 60
Query: 61 FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL 120
+ G+I R AEE+L K+ H GAFLIRESES+PG+FS+SV +G+ VQHFKVLR+ +GKYFL
Sbjct: 61 YSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGKYFL 120
Query: 121 WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQP--TYVQALFDFDPQEDGELGFR 178
W KFNSLNELVD++R+T++++ +QIFLRD E + + P + QA FDF Q+ +L FR
Sbjct: 121 WEEKFNSLNELVDFYRTTTIAKKRQIFLRDEEPLLKSPGACFAQAQFDFSAQDPSQLSFR 180
Query: 179 RGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVN 214
RGD I V++ DP+WW+G G+ G FPR+YV PV+
Sbjct: 181 RGDIIEVLERPDPHWWRGRSCGRVGFFPRSYVQPVH 216
>gi|4758476 GRB2-related adaptor protein 2 [Homo sapiens]
Length = 330
Score = 170 bits (430), Expect = 1e-42
Identities = 80/150 (53%), Positives = 114/150 (76%), Gaps = 3/150 (2%)
Query: 1 MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW 60
MEA+AK+DF A+ +DELSF GD+LK+L+ + + W+KAEL ++G++PKN+I+++ W
Sbjct: 1 MEAVAKFDFTASGEDELSFHTGDVLKILSNQ--EEWFKAELGSQEGYVPKNFIDIQFPKW 58
Query: 61 FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL 120
F + R +AE +L + G F+IR S+S+PGDFS+SV+ +DVQHFKV+RD G YFL
Sbjct: 59 FHEGLSRHQAENLLMG-KEVGFFIIRASQSSPGDFSISVRHEDDVQHFKVMRDNKGNYFL 117
Query: 121 WVVKFNSLNELVDYHRSTSVSRNQQIFLRD 150
W KF SLN+LVDY+R+ S+SR +QIFLRD
Sbjct: 118 WTEKFPSLNKLVDYYRTNSISRQKQIFLRD 147
Score = 71.6 bits (174), Expect = 5e-13
Identities = 27/56 (48%), Positives = 40/56 (71%)
Query: 160 YVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNR 215
+ +AL+DF+ ED ELGF G+ + V+D+S+P+WW G H + G+FP NYV P+ R
Sbjct: 275 WARALYDFEALEDDELGFHSGEVVEVLDSSNPSWWTGRLHNKLGLFPANYVAPMTR 330
Score = 45.8 bits (107), Expect = 3e-05
Identities = 21/51 (41%), Positives = 32/51 (62%), Gaps = 1/51 (1%)
Query: 3 AIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYI 53
A A YDF+A DDEL F G++++VL + + +W+ L+ K G P NY+
Sbjct: 276 ARALYDFEALEDDELGFHSGEVVEVL-DSSNPSWWTGRLHNKLGLFPANYV 325
Score = 37.7 bits (86), Expect = 0.008
Identities = 16/48 (33%), Positives = 25/48 (52%), Gaps = 1/48 (2%)
Query: 163 ALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYV 210
A FDF + EL F GD + ++ N + W+K Q G P+N++
Sbjct: 5 AKFDFTASGEDELSFHTGDVLKILSNQE-EWFKAELGSQEGYVPKNFI 51
>gi|193220941 hypothetical protein LOC400581 [Homo sapiens]
Length = 118
Score = 144 bits (362), Expect = 7e-35
Identities = 66/99 (66%), Positives = 81/99 (81%)
Query: 1 MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW 60
ME++A Y F+AT DEL+F +GD LK+LN E DQNWYKAEL G +GFIPKNYI +KPHPW
Sbjct: 1 MESVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIRVKPHPW 60
Query: 61 FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSV 99
+ G+I R AEE+L K+ H GAFLIRESES+PG+FS+SV
Sbjct: 61 YSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSV 99
Score = 43.9 bits (102), Expect = 1e-04
Identities = 18/49 (36%), Positives = 27/49 (55%), Gaps = 1/49 (2%)
Query: 163 ALFDFDPQEDGELGFRRGDFIHVMD-NSDPNWWKGACHGQTGMFPRNYV 210
AL+ F E EL F +GD + +++ D NW+K G G P+NY+
Sbjct: 5 ALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYI 53
>gi|5453754 NCK adaptor protein 1 [Homo sapiens]
Length = 377
Score = 100 bits (249), Expect = 9e-22
Identities = 58/172 (33%), Positives = 100/172 (58%), Gaps = 33/172 (19%)
Query: 5 AKYDFKATADDELSFKRGDILKVLNE-ECDQNWYKA-ELNGKDGFIPKNYI--------- 53
A Y F ++ D+EL+F++GD++ V+ + E D W+K ++NG G +PKNY+
Sbjct: 197 ALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVGLVPKNYVTVMQNNPLT 256
Query: 54 ---EMKP----------------HPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGD 94
E P +PW++GK+ R +AE L+++ H+G FLIR+SES+P D
Sbjct: 257 SGLEPSPPQCDYIRPSLTGKFAGNPWYYGKVTRHQAEMALNERGHEGDFLIRDSESSPND 316
Query: 95 FSLSVKFGNDVQHFKV-LRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQ 145
FS+S+K +HFKV L++ Y + KF+++ ELV++++ + ++Q
Sbjct: 317 FSVSLKAQGKNKHFKVQLKETV--YCIGQRKFSTMEELVEHYKKAPIFTSEQ 366
Score = 63.2 bits (152), Expect = 2e-10
Identities = 66/249 (26%), Positives = 105/249 (42%), Gaps = 39/249 (15%)
Query: 4 IAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELN-GKDGFIPKNYIEMK------ 56
+AK+D+ A + EL K+ + L +L++ ++W++ + K GF+P NY+E K
Sbjct: 8 VAKFDYVAQQEQELDIKKNERLWLLDDS--KSWWRVRNSMNKTGFVPSNYVERKNSARKA 65
Query: 57 ------PHPWFFGKIPRAKAEEMLSKQRHDGAFL--------------IRESESAPGDFS 96
GK+ R K S D +F+ ++ + A +
Sbjct: 66 SIVKNLKDTLGIGKVKR-KPSVPDSASPADDSFVDPGERLYDLNMPAYVKFNYMAEREDE 124
Query: 97 LSVKFGNDVQHFKVLRDG--AGKYFLWVVKF--NSLNELVDYHRSTSVSRNQQIFLRDIE 152
LS+ G V + DG G Y V F N + E D V + +
Sbjct: 125 LSLIKGTKVIVMEKCSDGWWRGSYNGQVGWFPSNYVTEEGDSPLGDHVGSLSEKLAAVVN 184
Query: 153 QVP--QQPTYVQALFDFDPQEDGELGFRRGDFIHVMD--NSDPNWWK-GACHGQTGMFPR 207
+ Q VQAL+ F D EL F +GD + V++ +DP WWK +G G+ P+
Sbjct: 185 NLNTGQVLHVVQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVGLVPK 244
Query: 208 NYVTPVNRN 216
NYVT + N
Sbjct: 245 NYVTVMQNN 253
Score = 44.3 bits (103), Expect = 8e-05
Identities = 19/53 (35%), Positives = 32/53 (60%), Gaps = 1/53 (1%)
Query: 1 MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYI 53
M A K+++ A +DELS +G + V+ E+C W++ NG+ G+ P NY+
Sbjct: 109 MPAYVKFNYMAEREDELSLIKGTKVIVM-EKCSDGWWRGSYNGQVGWFPSNYV 160
Score = 33.5 bits (75), Expect = 0.14
Identities = 17/54 (31%), Positives = 28/54 (51%)
Query: 161 VQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVN 214
V A FD+ Q++ EL ++ + + ++D+S W +TG P NYV N
Sbjct: 7 VVAKFDYVAQQEQELDIKKNERLWLLDDSKSWWRVRNSMNKTGFVPSNYVERKN 60
>gi|187475373 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 98.6 bits (244), Expect = 4e-21
Identities = 54/147 (36%), Positives = 84/147 (57%), Gaps = 12/147 (8%)
Query: 2 EAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELN-GKDGFIPKNYIEMKP--- 57
E IAKY+F TA+ +L F +GD+L ++ D NWYKA+ G++G IP NY++ +
Sbjct: 13 ECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVK 72
Query: 58 -------HPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKV 110
PWF GKI R +AE +L G FL+RES + PGD++L V V+H+++
Sbjct: 73 AGTKLSLMPWFHGKITREQAERLLYPP-ETGLFLVRESTNYPGDYTLCVSCDGKVEHYRI 131
Query: 111 LRDGAGKYFLWVVKFNSLNELVDYHRS 137
+ + V F +L +LV+++ S
Sbjct: 132 MYHASKLSIDEEVYFENLMQLVEHYTS 158
>gi|4758078 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 98.6 bits (244), Expect = 4e-21
Identities = 54/147 (36%), Positives = 84/147 (57%), Gaps = 12/147 (8%)
Query: 2 EAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELN-GKDGFIPKNYIEMKP--- 57
E IAKY+F TA+ +L F +GD+L ++ D NWYKA+ G++G IP NY++ +
Sbjct: 13 ECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVK 72
Query: 58 -------HPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKV 110
PWF GKI R +AE +L G FL+RES + PGD++L V V+H+++
Sbjct: 73 AGTKLSLMPWFHGKITREQAERLLYPP-ETGLFLVRESTNYPGDYTLCVSCDGKVEHYRI 131
Query: 111 LRDGAGKYFLWVVKFNSLNELVDYHRS 137
+ + V F +L +LV+++ S
Sbjct: 132 MYHASKLSIDEEVYFENLMQLVEHYTS 158
>gi|4503787 fyn-related kinase [Homo sapiens]
Length = 505
Score = 96.7 bits (239), Expect = 1e-20
Identities = 57/150 (38%), Positives = 89/150 (59%), Gaps = 14/150 (9%)
Query: 4 IAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGK--------DGFIPKNYI-- 53
+A +D++A ++LSF+ GD L+VL+ + W+ L + G+IP NY+
Sbjct: 48 VALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVAE 107
Query: 54 --EMKPHPWFFGKIPRAKAE-EMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKV 110
++ PWFFG I R+ AE ++L + G+FLIRESES G+FSLSV G V+H+++
Sbjct: 108 DRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRI 167
Query: 111 LRDGAGKYFLWVVK-FNSLNELVDYHRSTS 139
R G +FL + F++LNE V ++ TS
Sbjct: 168 KRLDEGGFFLTRRRIFSTLNEFVSHYTKTS 197
Score = 38.1 bits (87), Expect = 0.006
Identities = 20/60 (33%), Positives = 26/60 (43%), Gaps = 9/60 (15%)
Query: 160 YVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWW---------KGACHGQTGMFPRNYV 210
Y ALFD+ + +L FR GD + V+D WW G+ G P NYV
Sbjct: 46 YFVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYV 105
>gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 95.5 bits (236), Expect = 3e-20
Identities = 57/145 (39%), Positives = 89/145 (61%), Gaps = 14/145 (9%)
Query: 4 IAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAEL--NGKDGFIPKNYI----EMKP 57
IA YD++A +D+L+F +G+ +LN + +W++A +GK G IP NY+ ++
Sbjct: 83 IALYDYEARTEDDLTFTKGEKFHILNNT-EGDWWEARSLSSGKTGCIPSNYVAPVDSIQA 141
Query: 58 HPWFFGKIPRAKAE-EMLSKQRHDGAFLIRESESAPGDFSLSVK-----FGNDVQHFKVL 111
W+FGKI R AE ++LS GAFLIRESE+ G +SLS++ G+ V+H+K+
Sbjct: 142 EEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIR 201
Query: 112 R-DGAGKYFLWVVKFNSLNELVDYH 135
+ D G Y V+FNS+ ELV ++
Sbjct: 202 KLDMGGYYITTRVQFNSVQELVQHY 226
Score = 50.8 bits (120), Expect = 9e-07
Identities = 19/54 (35%), Positives = 36/54 (66%), Gaps = 2/54 (3%)
Query: 163 ALFDFDPQEDGELGFRRGDFIHVMDNSDPNWW--KGACHGQTGMFPRNYVTPVN 214
AL+D++ + + +L F +G+ H+++N++ +WW + G+TG P NYV PV+
Sbjct: 84 ALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVD 137
>gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 95.5 bits (236), Expect = 3e-20
Identities = 57/145 (39%), Positives = 89/145 (61%), Gaps = 14/145 (9%)
Query: 4 IAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAEL--NGKDGFIPKNYI----EMKP 57
IA YD++A +D+L+F +G+ +LN + +W++A +GK G IP NY+ ++
Sbjct: 83 IALYDYEARTEDDLTFTKGEKFHILNNT-EGDWWEARSLSSGKTGCIPSNYVAPVDSIQA 141
Query: 58 HPWFFGKIPRAKAE-EMLSKQRHDGAFLIRESESAPGDFSLSVK-----FGNDVQHFKVL 111
W+FGKI R AE ++LS GAFLIRESE+ G +SLS++ G+ V+H+K+
Sbjct: 142 EEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIR 201
Query: 112 R-DGAGKYFLWVVKFNSLNELVDYH 135
+ D G Y V+FNS+ ELV ++
Sbjct: 202 KLDMGGYYITTRVQFNSVQELVQHY 226
Score = 50.8 bits (120), Expect = 9e-07
Identities = 19/54 (35%), Positives = 36/54 (66%), Gaps = 2/54 (3%)
Query: 163 ALFDFDPQEDGELGFRRGDFIHVMDNSDPNWW--KGACHGQTGMFPRNYVTPVN 214
AL+D++ + + +L F +G+ H+++N++ +WW + G+TG P NYV PV+
Sbjct: 84 ALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVD 137
>gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 95.5 bits (236), Expect = 3e-20
Identities = 57/145 (39%), Positives = 89/145 (61%), Gaps = 14/145 (9%)
Query: 4 IAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAEL--NGKDGFIPKNYI----EMKP 57
IA YD++A +D+L+F +G+ +LN + +W++A +GK G IP NY+ ++
Sbjct: 83 IALYDYEARTEDDLTFTKGEKFHILNNT-EGDWWEARSLSSGKTGCIPSNYVAPVDSIQA 141
Query: 58 HPWFFGKIPRAKAE-EMLSKQRHDGAFLIRESESAPGDFSLSVK-----FGNDVQHFKVL 111
W+FGKI R AE ++LS GAFLIRESE+ G +SLS++ G+ V+H+K+
Sbjct: 142 EEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIR 201
Query: 112 R-DGAGKYFLWVVKFNSLNELVDYH 135
+ D G Y V+FNS+ ELV ++
Sbjct: 202 KLDMGGYYITTRVQFNSVQELVQHY 226
Score = 50.8 bits (120), Expect = 9e-07
Identities = 19/54 (35%), Positives = 36/54 (66%), Gaps = 2/54 (3%)
Query: 163 ALFDFDPQEDGELGFRRGDFIHVMDNSDPNWW--KGACHGQTGMFPRNYVTPVN 214
AL+D++ + + +L F +G+ H+++N++ +WW + G+TG P NYV PV+
Sbjct: 84 ALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVD 137
>gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens]
Length = 451
Score = 95.1 bits (235), Expect = 4e-20
Identities = 58/155 (37%), Positives = 88/155 (56%), Gaps = 14/155 (9%)
Query: 4 IAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGK------DGFIPKNYIE--- 54
+ +DFK+ D+ELSF+ GD+ V +E + W+ A L + G++P NY+
Sbjct: 14 VGLWDFKSRTDEELSFRAGDVFHVARKE--EQWWWATLLDEAGGAVAQGYVPHNYLAERE 71
Query: 55 -MKPHPWFFGKIPRAKAEEMLSKQRH-DGAFLIRESESAPGDFSLSVKFGNDVQHFKVLR 112
++ PWFFG I R++A L + + GAFLIR SE D+ LSV+ V+H+K+ R
Sbjct: 72 TVESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQAVRHYKIWR 131
Query: 113 DGAGKYFL-WVVKFNSLNELVDYHRSTSVSRNQQI 146
G+ L V F SL ELV+YHR+ S+S ++
Sbjct: 132 RAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGLRL 166
Score = 38.1 bits (87), Expect = 0.006
Identities = 21/59 (35%), Positives = 26/59 (44%), Gaps = 1/59 (1%)
Query: 152 EQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYV 210
+Q P YV L+DF + D EL FR GD HV + WW G + YV
Sbjct: 5 DQAHLGPKYV-GLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYV 62
>gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens]
Length = 845
Score = 95.1 bits (235), Expect = 4e-20
Identities = 61/223 (27%), Positives = 110/223 (49%), Gaps = 31/223 (13%)
Query: 17 LSFKRGDILKVLNEECDQNWYKAELNGKD--GFIPKNYI---------EMKPHPWFFGKI 65
L GDI+++ E +QNW++ + G+ P N + ++ H W+ G +
Sbjct: 617 LRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWFPCNRVKPYVHGPPQDLSVHLWYAGPM 676
Query: 66 PRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVK- 124
RA AE +L+ R DG FL+R+ +F++S+K+ +V+H K++ G Y + K
Sbjct: 677 ERAGAESILAN-RSDGTFLVRQRVKDAAEFAISIKYNVEVKHIKIM-TAEGLYRITEKKA 734
Query: 125 FNSLNELVDYHRSTSVS---RNQQIFLRDIEQVPQQPTY-------------VQALFDFD 168
F L ELV++++ S+ ++ L+ + P++ T +A +DF
Sbjct: 735 FRGLTELVEFYQQNSLKDCFKSLDTTLQFPFKEPEKRTISRPAVGSTKYFGTAKARYDFC 794
Query: 169 PQEDGELGFRRGDFIHVMD-NSDPNWWKGACHGQTGMFPRNYV 210
++ EL + GD I +++ WW+G +G+ G FP NYV
Sbjct: 795 ARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRVGWFPANYV 837
Score = 58.2 bits (139), Expect = 5e-09
Identities = 25/52 (48%), Positives = 36/52 (69%)
Query: 3 AIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIE 54
A A+YDF A ELS K GDI+K+LN++ Q W++ E+ G+ G+ P NY+E
Sbjct: 787 AKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRVGWFPANYVE 838
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 94.0 bits (232), Expect = 9e-20
Identities = 51/141 (36%), Positives = 83/141 (58%), Gaps = 6/141 (4%)
Query: 4 IAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYI----EMKPHP 59
+A YDF A+ D+ LS +G+ L+VL + W +A+ G++P NYI ++ H
Sbjct: 67 VALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHS 126
Query: 60 WFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGK-Y 118
W+ G + R AE +LS +G+FL+RESES+PG S+S+++ V H+++ GK Y
Sbjct: 127 WYHGPVSRNAAEYLLS-SGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLY 185
Query: 119 FLWVVKFNSLNELVDYHRSTS 139
+FN+L ELV +H + +
Sbjct: 186 VSSESRFNTLAELVHHHSTVA 206
Score = 37.7 bits (86), Expect = 0.008
Identities = 19/58 (32%), Positives = 27/58 (46%), Gaps = 1/58 (1%)
Query: 158 PTYVQALFDFDPQEDGELGFRRGDFIHVMD-NSDPNWWKGACHGQTGMFPRNYVTPVN 214
P AL+DF D L +G+ + V+ N + W + G P NY+TPVN
Sbjct: 63 PNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVN 120
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 94.0 bits (232), Expect = 9e-20
Identities = 51/141 (36%), Positives = 83/141 (58%), Gaps = 6/141 (4%)
Query: 4 IAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYI----EMKPHP 59
+A YDF A+ D+ LS +G+ L+VL + W +A+ G++P NYI ++ H
Sbjct: 86 VALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHS 145
Query: 60 WFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGK-Y 118
W+ G + R AE +LS +G+FL+RESES+PG S+S+++ V H+++ GK Y
Sbjct: 146 WYHGPVSRNAAEYLLS-SGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLY 204
Query: 119 FLWVVKFNSLNELVDYHRSTS 139
+FN+L ELV +H + +
Sbjct: 205 VSSESRFNTLAELVHHHSTVA 225
Score = 37.7 bits (86), Expect = 0.008
Identities = 19/58 (32%), Positives = 27/58 (46%), Gaps = 1/58 (1%)
Query: 158 PTYVQALFDFDPQEDGELGFRRGDFIHVMD-NSDPNWWKGACHGQTGMFPRNYVTPVN 214
P AL+DF D L +G+ + V+ N + W + G P NY+TPVN
Sbjct: 82 PNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVN 139
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 92.8 bits (229), Expect = 2e-19
Identities = 48/141 (34%), Positives = 83/141 (58%), Gaps = 6/141 (4%)
Query: 4 IAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYI----EMKPHP 59
+A YDF A+ D+ LS +G+ L+VL + W + G++P NYI ++ H
Sbjct: 98 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHS 157
Query: 60 WFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYF 119
W+ G + R+ AE +LS + G+FL+RESES+PG S+S+++ V H+++ GK +
Sbjct: 158 WYHGPVSRSAAEYLLSSLIN-GSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVY 216
Query: 120 LWV-VKFNSLNELVDYHRSTS 139
+ +F++L ELV +H + +
Sbjct: 217 VTAESRFSTLAELVHHHSTVA 237
Score = 36.6 bits (83), Expect = 0.017
Identities = 19/58 (32%), Positives = 27/58 (46%), Gaps = 1/58 (1%)
Query: 158 PTYVQALFDFDPQEDGELGFRRGDFIHVMD-NSDPNWWKGACHGQTGMFPRNYVTPVN 214
P AL+DF D L +G+ + V+ N + W + G P NY+TPVN
Sbjct: 94 PNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVN 151
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 92.8 bits (229), Expect = 2e-19
Identities = 48/141 (34%), Positives = 83/141 (58%), Gaps = 6/141 (4%)
Query: 4 IAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYI----EMKPHP 59
+A YDF A+ D+ LS +G+ L+VL + W + G++P NYI ++ H
Sbjct: 113 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHS 172
Query: 60 WFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYF 119
W+ G + R+ AE +LS + G+FL+RESES+PG S+S+++ V H+++ GK +
Sbjct: 173 WYHGPVSRSAAEYLLSSLIN-GSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVY 231
Query: 120 LWV-VKFNSLNELVDYHRSTS 139
+ +F++L ELV +H + +
Sbjct: 232 VTAESRFSTLAELVHHHSTVA 252
Score = 36.6 bits (83), Expect = 0.017
Identities = 19/58 (32%), Positives = 27/58 (46%), Gaps = 1/58 (1%)
Query: 158 PTYVQALFDFDPQEDGELGFRRGDFIHVMD-NSDPNWWKGACHGQTGMFPRNYVTPVN 214
P AL+DF D L +G+ + V+ N + W + G P NY+TPVN
Sbjct: 109 PNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVN 166
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 92.8 bits (229), Expect = 2e-19
Identities = 48/141 (34%), Positives = 83/141 (58%), Gaps = 6/141 (4%)
Query: 4 IAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYI----EMKPHP 59
+A YDF A+ D+ LS +G+ L+VL + W + G++P NYI ++ H
Sbjct: 92 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHS 151
Query: 60 WFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYF 119
W+ G + R+ AE +LS + G+FL+RESES+PG S+S+++ V H+++ GK +
Sbjct: 152 WYHGPVSRSAAEYLLSSLIN-GSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVY 210
Query: 120 LWV-VKFNSLNELVDYHRSTS 139
+ +F++L ELV +H + +
Sbjct: 211 VTAESRFSTLAELVHHHSTVA 231
Score = 36.6 bits (83), Expect = 0.017
Identities = 19/58 (32%), Positives = 27/58 (46%), Gaps = 1/58 (1%)
Query: 158 PTYVQALFDFDPQEDGELGFRRGDFIHVMD-NSDPNWWKGACHGQTGMFPRNYVTPVN 214
P AL+DF D L +G+ + V+ N + W + G P NY+TPVN
Sbjct: 88 PNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVN 145
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 92.8 bits (229), Expect = 2e-19
Identities = 48/141 (34%), Positives = 83/141 (58%), Gaps = 6/141 (4%)
Query: 4 IAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYI----EMKPHP 59
+A YDF A+ D+ LS +G+ L+VL + W + G++P NYI ++ H
Sbjct: 98 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHS 157
Query: 60 WFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYF 119
W+ G + R+ AE +LS + G+FL+RESES+PG S+S+++ V H+++ GK +
Sbjct: 158 WYHGPVSRSAAEYLLSSLIN-GSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVY 216
Query: 120 LWV-VKFNSLNELVDYHRSTS 139
+ +F++L ELV +H + +
Sbjct: 217 VTAESRFSTLAELVHHHSTVA 237
Score = 36.6 bits (83), Expect = 0.017
Identities = 19/58 (32%), Positives = 27/58 (46%), Gaps = 1/58 (1%)
Query: 158 PTYVQALFDFDPQEDGELGFRRGDFIHVMD-NSDPNWWKGACHGQTGMFPRNYVTPVN 214
P AL+DF D L +G+ + V+ N + W + G P NY+TPVN
Sbjct: 94 PNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVN 151
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 92.8 bits (229), Expect = 2e-19
Identities = 48/141 (34%), Positives = 83/141 (58%), Gaps = 6/141 (4%)
Query: 4 IAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYI----EMKPHP 59
+A YDF A+ D+ LS +G+ L+VL + W + G++P NYI ++ H
Sbjct: 77 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHS 136
Query: 60 WFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYF 119
W+ G + R+ AE +LS + G+FL+RESES+PG S+S+++ V H+++ GK +
Sbjct: 137 WYHGPVSRSAAEYLLSSLIN-GSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVY 195
Query: 120 LWV-VKFNSLNELVDYHRSTS 139
+ +F++L ELV +H + +
Sbjct: 196 VTAESRFSTLAELVHHHSTVA 216
Score = 36.6 bits (83), Expect = 0.017
Identities = 19/58 (32%), Positives = 27/58 (46%), Gaps = 1/58 (1%)
Query: 158 PTYVQALFDFDPQEDGELGFRRGDFIHVMD-NSDPNWWKGACHGQTGMFPRNYVTPVN 214
P AL+DF D L +G+ + V+ N + W + G P NY+TPVN
Sbjct: 73 PNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVN 130
>gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens]
Length = 482
Score = 91.7 bits (226), Expect = 4e-19
Identities = 52/148 (35%), Positives = 88/148 (59%), Gaps = 14/148 (9%)
Query: 4 IAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAE--LNGKDGFIPKNYI----EMKP 57
+A YD++A +D+LSF +G+ ++LN + +W++A G+ G+IP NY+ ++
Sbjct: 88 VALYDYEARTEDDLSFHKGEKFQILNSS-EGDWWEARSLTTGETGYIPSNYVAPVDSIQA 146
Query: 58 HPWFFGKIPRAKAE-EMLSKQRHDGAFLIRESESAPGDFSLSVK-----FGNDVQHFKVL 111
W+FGK+ R AE ++LS G FLIRESE+ G +SLS++ G+ V+H+K+
Sbjct: 147 EEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIR 206
Query: 112 R-DGAGKYFLWVVKFNSLNELVDYHRST 138
+ D G Y +F +L +LV ++ T
Sbjct: 207 KLDNGGYYITTRAQFETLQQLVQHYSGT 234
Score = 48.5 bits (114), Expect = 4e-06
Identities = 19/58 (32%), Positives = 36/58 (62%), Gaps = 2/58 (3%)
Query: 159 TYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWW--KGACHGQTGMFPRNYVTPVN 214
T AL+D++ + + +L F +G+ ++++S+ +WW + G+TG P NYV PV+
Sbjct: 85 TLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVD 142
>gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2
[Homo sapiens]
Length = 839
Score = 91.7 bits (226), Expect = 4e-19
Identities = 61/236 (25%), Positives = 105/236 (44%), Gaps = 43/236 (18%)
Query: 17 LSFKRGDILKVLNEECDQNWYKAEL--NGKDGFIPKNYIEMKP----------------- 57
L+F+ GD+L++L + + W++ L K G+ P + ++ P
Sbjct: 599 LTFQTGDVLELLRGDPESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISRPPSREIDY 658
Query: 58 --HPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGA 115
+PWF G + R + + +L K G +LIRE + F++S+KF ++V+H KV+
Sbjct: 659 TAYPWFAGNMERQQTDNLL-KSHASGTYLIRERPAEAERFAISIKFNDEVKHIKVVEKDN 717
Query: 116 GKYFLWVVKFNSLNELVDYHRSTSVSRN-------------------QQIFLRDIEQVPQ 156
+ KF+SL ELV+Y++ S+ + + R P+
Sbjct: 718 WIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASRASSRSPVFTPR 777
Query: 157 QPTYVQALFDFDPQEDGELGFRRGDFIHVMDN--SDPNWWKGACHGQTGMFPRNYV 210
A ++F ++ EL R GD + + D WWKG +G+ G FP YV
Sbjct: 778 VIGTAVARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYV 833
Score = 48.5 bits (114), Expect = 4e-06
Identities = 21/53 (39%), Positives = 34/53 (64%), Gaps = 1/53 (1%)
Query: 3 AIAKYDFKATADDELSFKRGDILKVLNE-ECDQNWYKAELNGKDGFIPKNYIE 54
A+A+Y+F A ELS + GD++++ + DQ W+K E NG+ G+ P Y+E
Sbjct: 782 AVARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYVE 834
>gi|112789548 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 90.1 bits (222), Expect = 1e-18
Identities = 58/168 (34%), Positives = 95/168 (56%), Gaps = 15/168 (8%)
Query: 4 IAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAE--LNGKDGFIPKNYI----EMKP 57
IA + ++ + D +L F++G+ L++L + + W+KA+ G++GFIP N++ ++P
Sbjct: 67 IALHSYEPSHDGDLGFEKGEQLRILEQSGE--WWKAQSLTTGQEGFIPFNFVAKANSLEP 124
Query: 58 HPWFFGKIPRAKAE-EMLSKQRHDGAFLIRESESAPGDFSLSVK-----FGNDVQHFKVL 111
PWFF + R AE ++L+ G+FLIRESES G FSLSV+ G V+H+K+
Sbjct: 125 EPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIR 184
Query: 112 R-DGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQP 158
D G Y + F L+ELV ++ + S ++ Q PQ+P
Sbjct: 185 NLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKP 232
Score = 48.1 bits (113), Expect = 6e-06
Identities = 23/62 (37%), Positives = 33/62 (53%), Gaps = 3/62 (4%)
Query: 155 PQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWK--GACHGQTGMFPRNYVTP 212
P Q V AL ++P DG+LGF +G+ + +++ S WWK GQ G P N+V
Sbjct: 60 PLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSG-EWWKAQSLTTGQEGFIPFNFVAK 118
Query: 213 VN 214
N
Sbjct: 119 AN 120
>gi|112789546 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 90.1 bits (222), Expect = 1e-18
Identities = 58/168 (34%), Positives = 95/168 (56%), Gaps = 15/168 (8%)
Query: 4 IAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAE--LNGKDGFIPKNYI----EMKP 57
IA + ++ + D +L F++G+ L++L + + W+KA+ G++GFIP N++ ++P
Sbjct: 67 IALHSYEPSHDGDLGFEKGEQLRILEQSGE--WWKAQSLTTGQEGFIPFNFVAKANSLEP 124
Query: 58 HPWFFGKIPRAKAE-EMLSKQRHDGAFLIRESESAPGDFSLSVK-----FGNDVQHFKVL 111
PWFF + R AE ++L+ G+FLIRESES G FSLSV+ G V+H+K+
Sbjct: 125 EPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIR 184
Query: 112 R-DGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQP 158
D G Y + F L+ELV ++ + S ++ Q PQ+P
Sbjct: 185 NLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKP 232
Score = 48.1 bits (113), Expect = 6e-06
Identities = 23/62 (37%), Positives = 33/62 (53%), Gaps = 3/62 (4%)
Query: 155 PQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWK--GACHGQTGMFPRNYVTP 212
P Q V AL ++P DG+LGF +G+ + +++ S WWK GQ G P N+V
Sbjct: 60 PLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSG-EWWKAQSLTTGQEGFIPFNFVAK 118
Query: 213 VN 214
N
Sbjct: 119 AN 120
>gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]
Length = 534
Score = 90.1 bits (222), Expect = 1e-18
Identities = 51/145 (35%), Positives = 87/145 (60%), Gaps = 14/145 (9%)
Query: 4 IAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAE--LNGKDGFIPKNYI----EMKP 57
+A YD++A +D+LSF +G+ ++LN + +W++A G+ G+IP NY+ ++
Sbjct: 88 VALYDYEARTEDDLSFHKGEKFQILNSS-EGDWWEARSLTTGETGYIPSNYVAPVDSIQA 146
Query: 58 HPWFFGKIPRAKAE-EMLSKQRHDGAFLIRESESAPGDFSLSVK-----FGNDVQHFKVL 111
W+FGK+ R AE ++LS G FLIRESE+ G +SLS++ G+ V+H+K+
Sbjct: 147 EEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIR 206
Query: 112 R-DGAGKYFLWVVKFNSLNELVDYH 135
+ D G Y +F +L +LV ++
Sbjct: 207 KLDNGGYYITTRAQFETLQQLVQHY 231
Score = 48.5 bits (114), Expect = 4e-06
Identities = 19/58 (32%), Positives = 36/58 (62%), Gaps = 2/58 (3%)
Query: 159 TYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWW--KGACHGQTGMFPRNYVTPVN 214
T AL+D++ + + +L F +G+ ++++S+ +WW + G+TG P NYV PV+
Sbjct: 85 TLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVD 142
>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
Length = 537
Score = 90.1 bits (222), Expect = 1e-18
Identities = 51/145 (35%), Positives = 87/145 (60%), Gaps = 14/145 (9%)
Query: 4 IAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAE--LNGKDGFIPKNYI----EMKP 57
+A YD++A +D+LSF +G+ ++LN + +W++A G+ G+IP NY+ ++
Sbjct: 88 VALYDYEARTEDDLSFHKGEKFQILNSS-EGDWWEARSLTTGETGYIPSNYVAPVDSIQA 146
Query: 58 HPWFFGKIPRAKAE-EMLSKQRHDGAFLIRESESAPGDFSLSVK-----FGNDVQHFKVL 111
W+FGK+ R AE ++LS G FLIRESE+ G +SLS++ G+ V+H+K+
Sbjct: 147 EEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIR 206
Query: 112 R-DGAGKYFLWVVKFNSLNELVDYH 135
+ D G Y +F +L +LV ++
Sbjct: 207 KLDNGGYYITTRAQFETLQQLVQHY 231
Score = 48.5 bits (114), Expect = 4e-06
Identities = 19/58 (32%), Positives = 36/58 (62%), Gaps = 2/58 (3%)
Query: 159 TYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWW--KGACHGQTGMFPRNYVTPVN 214
T AL+D++ + + +L F +G+ ++++S+ +WW + G+TG P NYV PV+
Sbjct: 85 TLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVD 142
>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 89.7 bits (221), Expect = 2e-18
Identities = 60/179 (33%), Positives = 100/179 (55%), Gaps = 25/179 (13%)
Query: 4 IAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELN-GKDGFIPKNYI----EMKPH 58
+A YD+++ + +LSFK+G+ L+++N W L+ G+ G+IP NY+ ++
Sbjct: 90 VALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAE 149
Query: 59 PWFFGKIPRAKAEE-MLSKQRHDGAFLIRESESAPGDFSLSVK-----FGNDVQHFKVLR 112
W+FGKI R ++E +L+ + G FL+RESE+ G + LSV G +V+H+K+ +
Sbjct: 150 EWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRK 209
Query: 113 -DGAGKYFLWVVKFNSLNELVDY---------HRSTSV---SRNQ-QIFLRDIEQVPQQ 157
D G Y +FNSL +LV Y HR T+V S+ Q Q +D ++P++
Sbjct: 210 LDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRE 268
Score = 47.8 bits (112), Expect = 7e-06
Identities = 18/52 (34%), Positives = 34/52 (65%), Gaps = 2/52 (3%)
Query: 163 ALFDFDPQEDGELGFRRGDFIHVMDNSDPNWW--KGACHGQTGMFPRNYVTP 212
AL+D++ + + +L F++G+ + +++N++ +WW GQTG P NYV P
Sbjct: 91 ALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAP 142
>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 89.7 bits (221), Expect = 2e-18
Identities = 60/179 (33%), Positives = 100/179 (55%), Gaps = 25/179 (13%)
Query: 4 IAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELN-GKDGFIPKNYI----EMKPH 58
+A YD+++ + +LSFK+G+ L+++N W L+ G+ G+IP NY+ ++
Sbjct: 90 VALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAE 149
Query: 59 PWFFGKIPRAKAEE-MLSKQRHDGAFLIRESESAPGDFSLSVK-----FGNDVQHFKVLR 112
W+FGKI R ++E +L+ + G FL+RESE+ G + LSV G +V+H+K+ +
Sbjct: 150 EWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRK 209
Query: 113 -DGAGKYFLWVVKFNSLNELVDY---------HRSTSV---SRNQ-QIFLRDIEQVPQQ 157
D G Y +FNSL +LV Y HR T+V S+ Q Q +D ++P++
Sbjct: 210 LDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRE 268
Score = 47.8 bits (112), Expect = 7e-06
Identities = 18/52 (34%), Positives = 34/52 (65%), Gaps = 2/52 (3%)
Query: 163 ALFDFDPQEDGELGFRRGDFIHVMDNSDPNWW--KGACHGQTGMFPRNYVTP 212
AL+D++ + + +L F++G+ + +++N++ +WW GQTG P NYV P
Sbjct: 91 ALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAP 142
>gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]
Length = 543
Score = 89.7 bits (221), Expect = 2e-18
Identities = 49/145 (33%), Positives = 89/145 (61%), Gaps = 14/145 (9%)
Query: 4 IAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAE--LNGKDGFIPKNYI----EMKP 57
+A YD++A ++LSFK+G+ +++N + +W++A GK+G+IP NY+ ++
Sbjct: 97 VALYDYEARTTEDLSFKKGERFQIIN-NTEGDWWEARSIATGKNGYIPSNYVAPADSIQA 155
Query: 58 HPWFFGKIPRAKAEE-MLSKQRHDGAFLIRESESAPGDFSLSVK-----FGNDVQHFKVL 111
W+FGK+ R AE +L+ G FL+RESE+ G +SLS++ G++V+H+K+
Sbjct: 156 EEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIR 215
Query: 112 R-DGAGKYFLWVVKFNSLNELVDYH 135
+ D G Y +F++L +LV ++
Sbjct: 216 KLDNGGYYITTRAQFDTLQKLVKHY 240
Score = 44.7 bits (104), Expect = 6e-05
Identities = 17/58 (29%), Positives = 34/58 (58%), Gaps = 2/58 (3%)
Query: 159 TYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWW--KGACHGQTGMFPRNYVTPVN 214
T AL+D++ + +L F++G+ +++N++ +WW + G+ G P NYV P +
Sbjct: 94 TIFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNYVAPAD 151
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.138 0.435
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 8,474,591
Number of Sequences: 37866
Number of extensions: 371202
Number of successful extensions: 1929
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 310
Number of HSP's successfully gapped in prelim test: 75
Number of HSP's that attempted gapping in prelim test: 733
Number of HSP's gapped (non-prelim): 864
length of query: 217
length of database: 18,247,518
effective HSP length: 98
effective length of query: 119
effective length of database: 14,536,650
effective search space: 1729861350
effective search space used: 1729861350
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.