Search of human proteins with 4503969

Search of human proteins with 4503969

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4503969 growth differentiation factor 5 preproprotein [Homo
sapiens]
         (501 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4503969 growth differentiation factor 5 preproprotein [Homo s...  1034   0.0  
gi|48475062 growth differentiation factor 6 precursor [Homo sapi...   341   1e-93
gi|61835232 growth differentiation factor 7 preproprotein [Homo ...   281   1e-75
gi|4557369 bone morphogenetic protein 2 preproprotein [Homo sapi...   154   1e-37
gi|157276597 bone morphogenetic protein 4 preproprotein [Homo sa...   152   9e-37
gi|157276595 bone morphogenetic protein 4 preproprotein [Homo sa...   152   9e-37
gi|157276593 bone morphogenetic protein 4 preproprotein [Homo sa...   152   9e-37
gi|10835091 bone morphogenetic protein 5 preproprotein [Homo sap...   149   4e-36
gi|4502427 bone morphogenetic protein 7 precursor [Homo sapiens]      140   3e-33
gi|29571106 bone morphogenetic protein 8B preproprotein [Homo sa...   138   1e-32
gi|145611428 bone morphogenetic protein 8A [Homo sapiens]             138   1e-32
gi|4502425 bone morphogenetic protein 6 preproprotein [Homo sapi...   137   3e-32
gi|7656928 bone morphogenetic protein 10 preproprotein [Homo sap...   132   1e-30
gi|7705308 growth differentiation factor 2 [Homo sapiens]             119   6e-27
gi|10190670 growth differentiation factor 3 precursor [Homo sapi...   119   8e-27
gi|126507087 bone morphogenetic protein 3 preproprotein [Homo sa...   115   1e-25
gi|110349792 growth differentiation factor 1 [Homo sapiens]           110   2e-24
gi|4826740 growth differentiation factor 10 precursor [Homo sapi...   109   7e-24
gi|4885097 bone morphogenetic protein 15 precursor [Homo sapiens]     107   3e-23
gi|222352098 nodal precursor [Homo sapiens]                           103   4e-22
gi|4504699 inhibin beta A precursor [Homo sapiens]                     93   6e-19
gi|13899338 activin beta E [Homo sapiens]                              86   1e-16
gi|4885259 myostatin [Homo sapiens]                                    84   4e-16
gi|5031613 growth differentiation factor 11 precursor [Homo sapi...    83   5e-16
gi|4885261 growth differentiation factor 9 precursor [Homo sapiens]    80   4e-15
gi|154813204 inhibin beta B subunit preproprotein [Homo sapiens]       80   4e-15
gi|5031795 inhibin beta C chain preproprotein [Homo sapiens]           75   1e-13
gi|4507465 transforming growth factor, beta 3 [Homo sapiens]           72   2e-12
gi|208022653 transforming growth factor, beta 2 isoform 1 [Homo ...    69   1e-11
gi|4507463 transforming growth factor, beta 2 isoform 2 [Homo sa...    69   1e-11

>gi|4503969 growth differentiation factor 5 preproprotein [Homo
           sapiens]
          Length = 501

 Score = 1034 bits (2673), Expect = 0.0
 Identities = 501/501 (100%), Positives = 501/501 (100%)

Query: 1   MRLPKLLTFLLWYLAWLDLEFICTVLGAPDLGQRPQGTRPGLAKAEAKERPPLARNVFRP 60
           MRLPKLLTFLLWYLAWLDLEFICTVLGAPDLGQRPQGTRPGLAKAEAKERPPLARNVFRP
Sbjct: 1   MRLPKLLTFLLWYLAWLDLEFICTVLGAPDLGQRPQGTRPGLAKAEAKERPPLARNVFRP 60

Query: 61  GGHSYGGGATNANARAKGGTGQTGGLTQPKKDEPKKLPPRPGGPEPKPGHPPQTRQATAR 120
           GGHSYGGGATNANARAKGGTGQTGGLTQPKKDEPKKLPPRPGGPEPKPGHPPQTRQATAR
Sbjct: 61  GGHSYGGGATNANARAKGGTGQTGGLTQPKKDEPKKLPPRPGGPEPKPGHPPQTRQATAR 120

Query: 121 TVTPKGQLPGGKAPPKAGSVPSSFLLKKAREPGPPREPKEPFRPPPITPHEYMLSLYRTL 180
           TVTPKGQLPGGKAPPKAGSVPSSFLLKKAREPGPPREPKEPFRPPPITPHEYMLSLYRTL
Sbjct: 121 TVTPKGQLPGGKAPPKAGSVPSSFLLKKAREPGPPREPKEPFRPPPITPHEYMLSLYRTL 180

Query: 181 SDADRKGGNSSVKLEAGLANTITSFIDKGQDDRGPVVRKQRYVFDISALEKDGLLGAELR 240
           SDADRKGGNSSVKLEAGLANTITSFIDKGQDDRGPVVRKQRYVFDISALEKDGLLGAELR
Sbjct: 181 SDADRKGGNSSVKLEAGLANTITSFIDKGQDDRGPVVRKQRYVFDISALEKDGLLGAELR 240

Query: 241 ILRKKPSDTAKPAAPGGGRAAQLKLSSCPSGRQPASLLDVRSVPGLDGSGWEVFDIWKLF 300
           ILRKKPSDTAKPAAPGGGRAAQLKLSSCPSGRQPASLLDVRSVPGLDGSGWEVFDIWKLF
Sbjct: 241 ILRKKPSDTAKPAAPGGGRAAQLKLSSCPSGRQPASLLDVRSVPGLDGSGWEVFDIWKLF 300

Query: 301 RNFKNSAQLCLELEAWERGRAVDLRGLGFDRAARQVHEKALFLVFGRTKKRDLFFNEIKA 360
           RNFKNSAQLCLELEAWERGRAVDLRGLGFDRAARQVHEKALFLVFGRTKKRDLFFNEIKA
Sbjct: 301 RNFKNSAQLCLELEAWERGRAVDLRGLGFDRAARQVHEKALFLVFGRTKKRDLFFNEIKA 360

Query: 361 RSGQDDKTVYEYLFSQRRKRRAPLATRQGKRPSKNLKARCSRKALHVNFKDMGWDDWIIA 420
           RSGQDDKTVYEYLFSQRRKRRAPLATRQGKRPSKNLKARCSRKALHVNFKDMGWDDWIIA
Sbjct: 361 RSGQDDKTVYEYLFSQRRKRRAPLATRQGKRPSKNLKARCSRKALHVNFKDMGWDDWIIA 420

Query: 421 PLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFID 480
           PLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFID
Sbjct: 421 PLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFID 480

Query: 481 SANNVVYKQYEDMVVESCGCR 501
           SANNVVYKQYEDMVVESCGCR
Sbjct: 481 SANNVVYKQYEDMVVESCGCR 501


>gi|48475062 growth differentiation factor 6 precursor [Homo
           sapiens]
          Length = 455

 Score =  341 bits (874), Expect = 1e-93
 Identities = 195/386 (50%), Positives = 250/386 (64%), Gaps = 49/386 (12%)

Query: 155 PREPKEPFRPPPITPHEYMLSLYRTLSDADRKGGNSSVKLEAGLANTITSFIDKGQDDRG 214
           PR  + P R P + PHEYMLS+YRT S A++ G N+S    +  ANTITSF+D+G DD  
Sbjct: 80  PRAQEPPGRGPRVVPHEYMLSIYRTYSIAEKLGINASFFQSSKSANTITSFVDRGLDDLS 139

Query: 215 PV-VRKQRYVFDISAL-EKDGLLGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSCPSGR 272
              +R+Q+Y+FD+S L +K+ L+GAELR+ R+ PS      AP G  A  L +   P   
Sbjct: 140 HTPLRRQKYLFDVSMLSDKEELVGAELRLFRQAPS------APWGPPAGPLHVQLFPC-- 191

Query: 273 QPASLLDVRSV--PGLDGSGWEVFDIWKLFRNFKNSAQLCLELE-AW---ERGRA----- 321
               LLD R++   G   +GWEVFD+W+  R+ +   QLCLEL  AW   + G A     
Sbjct: 192 LSPLLLDARTLDPQGAPPAGWEVFDVWQGLRH-QPWKQLCLELRAAWGELDAGEAEARAR 250

Query: 322 -------VDLRGLGFDRAARQVHEKALFLVFGRTKKRDLFFNEIKARSGQDDKT------ 368
                   DLR LGF R  R   E+AL +VF R+++++L F E++ + G  +        
Sbjct: 251 GPQQPPPPDLRSLGFGRRVRPPQERALLVVFTRSQRKNL-FAEMREQLGSAEAAGPGAGA 309

Query: 369 ------------VYEYLFSQ-RRKRRAPLATRQGKRPSKNLKARCSRKALHVNFKDMGWD 415
                          +L S  RR+RR   A+R GKR  K  + RCS+K LHVNFK++GWD
Sbjct: 310 EGSWPPPSGAPDARPWLPSPGRRRRRTAFASRHGKRHGKKSRLRCSKKPLHVNFKELGWD 369

Query: 416 DWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPIS 475
           DWIIAPLEYEA+HCEG+C+FPLRSHLEPTNHA+IQTLMNSMDP STPP+CCVPT+L+PIS
Sbjct: 370 DWIIAPLEYEAYHCEGVCDFPLRSHLEPTNHAIIQTLMNSMDPGSTPPSCCVPTKLTPIS 429

Query: 476 ILFIDSANNVVYKQYEDMVVESCGCR 501
           IL+ID+ NNVVYKQYEDMVVESCGCR
Sbjct: 430 ILYIDAGNNVVYKQYEDMVVESCGCR 455


>gi|61835232 growth differentiation factor 7 preproprotein [Homo
           sapiens]
          Length = 450

 Score =  281 bits (718), Expect = 1e-75
 Identities = 165/405 (40%), Positives = 228/405 (56%), Gaps = 46/405 (11%)

Query: 131 GKAPPKAGSVPSSFLLKKAREPGPPREPKEPFRPPPITPHEYMLSLYRTLSDADRKGGNS 190
           G A   A +VP +   ++A   G        FR   + PH +M+SLYR+L+     G  +
Sbjct: 58  GAAAVPAAAVPRARAARRAAGSG--------FRNGSVVPHHFMMSLYRSLAGRAPAGAAA 109

Query: 191 SVKLEAGLANTITSFIDKGQDDRGPVVRKQRYVFDISAL-EKDGLLGAELRILRKKPSDT 249
                 G A+TIT F D+   D       Q ++FD+S+L + D ++GAELR+LR+   + 
Sbjct: 110 VSASGHGRADTITGFTDQATQDESAAETGQSFLFDVSSLNDADEVVGAELRVLRRGSPE- 168

Query: 250 AKPAAPGGGRAAQ-LKLSSCPSGRQPASLLDVRSVPGLDGSGWEVFDIWKLFRNFKNSAQ 308
              + PG   +   L LS+CP   +   LL  R+   L G  WE FD+    R  +   +
Sbjct: 169 ---SGPGSWTSPPLLLLSTCPGAARAPRLLYSRAAEPLVGQRWEAFDVADAMRRHRREPR 225

Query: 309 ------LCLELEAWERGRAVDLRGLGF---DRAARQVHEKALFLVFGRTKKRDLFFNEIK 359
                 L L   A      + LR LGF           E+A+ +V  RT++++  F EI+
Sbjct: 226 PPRAFCLLLRAVAGPVPSPLALRRLGFGWPGGGGSAAEERAVLVVSSRTQRKESLFREIR 285

Query: 360 ARS---------------GQDDKTVYEYLFSQRRKRRAPLATR--------QGKRPSKNL 396
           A++               G    +    +  +RR+R A   TR         G+   +  
Sbjct: 286 AQARALGAALASEPLPDPGTGTASPRAVIGGRRRRRTALAGTRTAQGSGGGAGRGHGRRG 345

Query: 397 KARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSM 456
           ++RCSRK LHV+FK++GWDDWIIAPL+YEA+HCEGLC+FPLRSHLEPTNHA+IQTL+NSM
Sbjct: 346 RSRCSRKPLHVDFKELGWDDWIIAPLDYEAYHCEGLCDFPLRSHLEPTNHAIIQTLLNSM 405

Query: 457 DPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR 501
            P++ P +CCVP RLSPISIL+ID+ANNVVYKQYEDMVVE+CGCR
Sbjct: 406 APDAAPASCCVPARLSPISILYIDAANNVVYKQYEDMVVEACGCR 450


>gi|4557369 bone morphogenetic protein 2 preproprotein [Homo
           sapiens]
          Length = 396

 Score =  154 bits (390), Expect = 1e-37
 Identities = 122/391 (31%), Positives = 179/391 (45%), Gaps = 52/391 (13%)

Query: 130 GGKAPPKAGSVPSSFLLKKAREPGPPREPKEPFRPPPITPHEYMLSLYRTLS-DADRKGG 188
           G  +   +  V S F L+     G  + P  P R   + P  YML LYR  S        
Sbjct: 39  GRPSSQPSDEVLSEFELRLLSMFGLKQRPT-PSRDAVVPP--YMLDLYRRHSGQPGSPAP 95

Query: 189 NSSVKLEAGLANTITSF-----IDKGQDDRGPVVRKQRYVFDISALEKDGLL-GAELRIL 242
           +  ++  A  ANT+ SF     +++  +  G   R  R+ F++S++  +  +  AEL++ 
Sbjct: 96  DHRLERAASRANTVRSFHHEESLEELPETSGKTTR--RFFFNLSSIPTEEFITSAELQVF 153

Query: 243 RKKPSDTAKPAAPGGGRA---AQLKLSSCPSGRQPASLLDVRSVPGLDGSGWEVFDIWKL 299
           R++  D     +    R      +K ++  S      LLD R V   + S WE FD+   
Sbjct: 154 REQMQDALGNNSSFHHRINIYEIIKPATANSKFPVTRLLDTRLV-NQNASRWESFDVTPA 212

Query: 300 FRNFKNSAQ----LCLELEAWERGRAVDLRGLGFDRAARQVHE-----KALFLVFGRTKK 350
              +           +E+   E  + V  R +   R+  Q        + L + FG   K
Sbjct: 213 VMRWTAQGHANHGFVVEVAHLEEKQGVSKRHVRISRSLHQDEHSWSQIRPLLVTFGHDGK 272

Query: 351 RDLFFNEIKARSGQDDKTVYEYLFSQRRKRRAPLATRQGKRPSKNLKARCSRKALHVNFK 410
                                +   +R KR+A    R      K LK+ C R  L+V+F 
Sbjct: 273 G--------------------HPLHKREKRQAKHKQR------KRLKSSCKRHPLYVDFS 306

Query: 411 DMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTR 470
           D+GW+DWI+AP  Y AF+C G C FPL  HL  TNHA++QTL+NS++    P  CCVPT 
Sbjct: 307 DVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVN-SKIPKACCVPTE 365

Query: 471 LSPISILFIDSANNVVYKQYEDMVVESCGCR 501
           LS IS+L++D    VV K Y+DMVVE CGCR
Sbjct: 366 LSAISMLYLDENEKVVLKNYQDMVVEGCGCR 396


>gi|157276597 bone morphogenetic protein 4 preproprotein [Homo
           sapiens]
          Length = 408

 Score =  152 bits (383), Expect = 9e-37
 Identities = 112/345 (32%), Positives = 171/345 (49%), Gaps = 31/345 (8%)

Query: 171 EYMLSLYRTLSDADRKGGNSSVKLE-----AGLANTITSFIDKGQDDRGPVVRKQ---RY 222
           +YM  LYR  S  + +    S  LE     A  ANT+ SF  +   +  P   +    R+
Sbjct: 81  DYMRDLYRLQSGEEEEEQIHSTGLEYPERPASRANTVRSFHHEEHLENIPGTSENSAFRF 140

Query: 223 VFDISAL-EKDGLLGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSCPS----GRQPASL 277
           +F++S++ E + +  AELR+ R++  D       G  R    ++   P+    G     L
Sbjct: 141 LFNLSSIPENEVISSAELRLFREQV-DQGPDWERGFHRINIYEVMKPPAEVVPGHLITRL 199

Query: 278 LDVRSVPGLDGSGWEVFDIWKLFRNFKNSAQLCLELEAWERGRAVDLRGLGFDRAARQVH 337
           LD R V   + + WE FD+      +    Q          G A+++  L   R  +  H
Sbjct: 200 LDTRLVHH-NVTRWETFDVSPAVLRWTREKQP-------NYGLAIEVTHLHQTRTHQGQH 251

Query: 338 EK-ALFLVFGRTKKRDLFFNEIKARSGQDDKTVYEYLFSQRRKRRAPLATRQGKRPSKNL 396
            + +  L  G      L    +    G D +       +  R+RRA  + +   + ++  
Sbjct: 252 VRISRSLPQGSGNWAQL--RPLLVTFGHDGRG-----HALTRRRRAKRSPKHHSQRARKK 304

Query: 397 KARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSM 456
              C R +L+V+F D+GW+DWI+AP  Y+AF+C G C FPL  HL  TNHA++QTL+NS+
Sbjct: 305 NKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSV 364

Query: 457 DPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR 501
           +  S P  CCVPT LS IS+L++D  + VV K Y++MVVE CGCR
Sbjct: 365 N-SSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR 408


>gi|157276595 bone morphogenetic protein 4 preproprotein [Homo
           sapiens]
          Length = 408

 Score =  152 bits (383), Expect = 9e-37
 Identities = 112/345 (32%), Positives = 171/345 (49%), Gaps = 31/345 (8%)

Query: 171 EYMLSLYRTLSDADRKGGNSSVKLE-----AGLANTITSFIDKGQDDRGPVVRKQ---RY 222
           +YM  LYR  S  + +    S  LE     A  ANT+ SF  +   +  P   +    R+
Sbjct: 81  DYMRDLYRLQSGEEEEEQIHSTGLEYPERPASRANTVRSFHHEEHLENIPGTSENSAFRF 140

Query: 223 VFDISAL-EKDGLLGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSCPS----GRQPASL 277
           +F++S++ E + +  AELR+ R++  D       G  R    ++   P+    G     L
Sbjct: 141 LFNLSSIPENEVISSAELRLFREQV-DQGPDWERGFHRINIYEVMKPPAEVVPGHLITRL 199

Query: 278 LDVRSVPGLDGSGWEVFDIWKLFRNFKNSAQLCLELEAWERGRAVDLRGLGFDRAARQVH 337
           LD R V   + + WE FD+      +    Q          G A+++  L   R  +  H
Sbjct: 200 LDTRLVHH-NVTRWETFDVSPAVLRWTREKQP-------NYGLAIEVTHLHQTRTHQGQH 251

Query: 338 EK-ALFLVFGRTKKRDLFFNEIKARSGQDDKTVYEYLFSQRRKRRAPLATRQGKRPSKNL 396
            + +  L  G      L    +    G D +       +  R+RRA  + +   + ++  
Sbjct: 252 VRISRSLPQGSGNWAQL--RPLLVTFGHDGRG-----HALTRRRRAKRSPKHHSQRARKK 304

Query: 397 KARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSM 456
              C R +L+V+F D+GW+DWI+AP  Y+AF+C G C FPL  HL  TNHA++QTL+NS+
Sbjct: 305 NKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSV 364

Query: 457 DPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR 501
           +  S P  CCVPT LS IS+L++D  + VV K Y++MVVE CGCR
Sbjct: 365 N-SSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR 408


>gi|157276593 bone morphogenetic protein 4 preproprotein [Homo
           sapiens]
          Length = 408

 Score =  152 bits (383), Expect = 9e-37
 Identities = 112/345 (32%), Positives = 171/345 (49%), Gaps = 31/345 (8%)

Query: 171 EYMLSLYRTLSDADRKGGNSSVKLE-----AGLANTITSFIDKGQDDRGPVVRKQ---RY 222
           +YM  LYR  S  + +    S  LE     A  ANT+ SF  +   +  P   +    R+
Sbjct: 81  DYMRDLYRLQSGEEEEEQIHSTGLEYPERPASRANTVRSFHHEEHLENIPGTSENSAFRF 140

Query: 223 VFDISAL-EKDGLLGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSCPS----GRQPASL 277
           +F++S++ E + +  AELR+ R++  D       G  R    ++   P+    G     L
Sbjct: 141 LFNLSSIPENEVISSAELRLFREQV-DQGPDWERGFHRINIYEVMKPPAEVVPGHLITRL 199

Query: 278 LDVRSVPGLDGSGWEVFDIWKLFRNFKNSAQLCLELEAWERGRAVDLRGLGFDRAARQVH 337
           LD R V   + + WE FD+      +    Q          G A+++  L   R  +  H
Sbjct: 200 LDTRLVHH-NVTRWETFDVSPAVLRWTREKQP-------NYGLAIEVTHLHQTRTHQGQH 251

Query: 338 EK-ALFLVFGRTKKRDLFFNEIKARSGQDDKTVYEYLFSQRRKRRAPLATRQGKRPSKNL 396
            + +  L  G      L    +    G D +       +  R+RRA  + +   + ++  
Sbjct: 252 VRISRSLPQGSGNWAQL--RPLLVTFGHDGRG-----HALTRRRRAKRSPKHHSQRARKK 304

Query: 397 KARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSM 456
              C R +L+V+F D+GW+DWI+AP  Y+AF+C G C FPL  HL  TNHA++QTL+NS+
Sbjct: 305 NKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSV 364

Query: 457 DPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR 501
           +  S P  CCVPT LS IS+L++D  + VV K Y++MVVE CGCR
Sbjct: 365 N-SSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR 408


>gi|10835091 bone morphogenetic protein 5 preproprotein [Homo
           sapiens]
          Length = 454

 Score =  149 bits (377), Expect = 4e-36
 Identities = 81/230 (35%), Positives = 124/230 (53%), Gaps = 16/230 (6%)

Query: 277 LLDVRSVPGLDGSGWEVFDI------WKLFRNFKNSAQLCLELEAWERGRAVDLRGLGFD 330
           LLD R    LD  GW VFDI      W +        QLC E      GR+++++  G  
Sbjct: 234 LLDTRKAQALD-VGWLVFDITVTSNHWVINPQNNLGLQLCAETGD---GRSINVKSAGL- 288

Query: 331 RAARQVHEKALFLVFGRTKKRDLFFNEIKARSGQDDKTVYEYLFSQRRKRRAPLATRQGK 390
              RQ  +     +    K  ++    ++A + + ++   +    Q   R + +    G 
Sbjct: 289 -VGRQGPQSKQPFMVAFFKASEVLLRSVRAANKRKNQNRNKSSSHQDSSRMSSV----GD 343

Query: 391 RPSKNLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQ 450
             +   K  C +  L+V+F+D+GW DWIIAP  Y AF+C+G C FPL +H+  TNHA++Q
Sbjct: 344 YNTSEQKQACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQ 403

Query: 451 TLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGC 500
           TL++ M P+  P  CC PT+L+ IS+L+ D ++NV+ K+Y +MVV SCGC
Sbjct: 404 TLVHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGC 453


>gi|4502427 bone morphogenetic protein 7 precursor [Homo sapiens]
          Length = 431

 Score =  140 bits (353), Expect = 3e-33
 Identities = 96/314 (30%), Positives = 169/314 (53%), Gaps = 25/314 (7%)

Query: 199 ANTITSFIDKGQDDRG---PVVRKQRYVFDISAL-EKDGLLGAELRILRKKPSDTAKPAA 254
           A+ + SF++  + D+    P    + + FD+S + E + +  AE RI +    +      
Sbjct: 130 ADMVMSFVNLVEHDKEFFHPRYHHREFRFDLSKIPEGEAVTAAEFRIYKDYIRERFDNET 189

Query: 255 PGGGRAAQLKLSSCPSGRQP-ASLLDVRSVPGLDGSGWEVFDI------WKLFRNFKNSA 307
               R +  ++     GR+    LLD R++   +  GW VFDI      W +  N +++ 
Sbjct: 190 ---FRISVYQVLQEHLGRESDLFLLDSRTLWASE-EGWLVFDITATSNHWVV--NPRHNL 243

Query: 308 QLCLELEAWERGRAVDLRGLGFDRAARQVHEKALFLVFGRTKKRDLFFNEIKAR-SGQDD 366
            L L +E  + G++++ +  G        +++   + F   K  ++ F  I++  S Q  
Sbjct: 244 GLQLSVETLD-GQSINPKLAGLIGRHGPQNKQPFMVAF--FKATEVHFRSIRSTGSKQRS 300

Query: 367 KTVYEYLFSQRRKRRAPLATRQGKRPSKNLKARCSRKALHVNFKDMGWDDWIIAPLEYEA 426
           +   +   +Q   R A +A    +  S + +  C +  L+V+F+D+GW DWIIAP  Y A
Sbjct: 301 QNRSKTPKNQEALRMANVA----ENSSSDQRQACKKHELYVSFRDLGWQDWIIAPEGYAA 356

Query: 427 FHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVV 486
           ++CEG C FPL S++  TNHA++QTL++ ++PE+ P  CC PT+L+ IS+L+ D ++NV+
Sbjct: 357 YYCEGECAFPLNSYMNATNHAIVQTLVHFINPETVPKPCCAPTQLNAISVLYFDDSSNVI 416

Query: 487 YKQYEDMVVESCGC 500
            K+Y +MVV +CGC
Sbjct: 417 LKKYRNMVVRACGC 430


>gi|29571106 bone morphogenetic protein 8B preproprotein [Homo
           sapiens]
          Length = 402

 Score =  138 bits (347), Expect = 1e-32
 Identities = 122/439 (27%), Positives = 198/439 (45%), Gaps = 97/439 (22%)

Query: 97  LPPRPGGPEPKPGHPPQTRQATARTVTPKGQLPGG---KAPPKAGSVPSSFLLKKAREPG 153
           L P PG P+ + G   + R+   R +     LPG    +APP A  +P+S  L       
Sbjct: 25  LRPPPGCPQRRLG--ARERRDVQREILAVLGLPGRPRPRAPPAASRLPASAPL------- 75

Query: 154 PPREPKEPFRPPPITPHEYMLSLYRTLSDADRKGGNSSVKLEAGLANTITSFIDKGQDDR 213
                             +ML LY  ++  D + G +  +   G A+ + SF++  + DR
Sbjct: 76  ------------------FMLDLYHAMAGDDDEDG-APAERRLGRADLVMSFVNMVERDR 116

Query: 214 GPVVRK---QRYVFDISALEK-DGLLGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSCP 269
               ++   + + FD++ +   + +  AE RI +                 +  ++    
Sbjct: 117 ALGHQEPHWKEFRFDLTQIPAGEAVTAAEFRIYKVPSIHLLNRTL----HVSMFQVVQEQ 172

Query: 270 SGRQP-ASLLDVRSVPGLDGSGWEVFDI------WKLFRNFKNSAQLCLELEAWERGRAV 322
           S R+     LD++++   D  GW V D+      W L R+     +L +E E    G +V
Sbjct: 173 SNRESDLFFLDLQTLRAGD-EGWLVLDVTAASDCWLLKRHKDLGLRLYVETED---GHSV 228

Query: 323 D--LRGLGFDRAARQVHEKALFLVFGRTKKRDLFFNEIKARSGQDDKTVYEYLFSQRRKR 380
           D  L GL   RA R   ++   + F R     +                        R  
Sbjct: 229 DPGLAGLLGQRAPRS--QQPFVVTFFRASPSPI------------------------RTP 262

Query: 381 RA--PLATRQGKRPSKNLKAR-----------------CSRKALHVNFKDMGWDDWIIAP 421
           RA  PL  RQ K+ ++  +A                  C R  L+V+F+D+GW DW+IAP
Sbjct: 263 RAVRPLRRRQPKKSNELPQANRLPGIFDDVHGSHGRQVCRRHELYVSFQDLGWLDWVIAP 322

Query: 422 LEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDS 481
             Y A++CEG C FPL S +  TNHA++Q+L++ M P++ P  CC PT+LS  S+L+ DS
Sbjct: 323 QGYSAYYCEGECSFPLDSCMNATNHAILQSLVHLMMPDAVPKACCAPTKLSATSVLYYDS 382

Query: 482 ANNVVYKQYEDMVVESCGC 500
           +NNV+ +++ +MVV++CGC
Sbjct: 383 SNNVILRKHRNMVVKACGC 401


>gi|145611428 bone morphogenetic protein 8A [Homo sapiens]
          Length = 402

 Score =  138 bits (347), Expect = 1e-32
 Identities = 122/439 (27%), Positives = 197/439 (44%), Gaps = 97/439 (22%)

Query: 97  LPPRPGGPEPKPGHPPQTRQATARTVTPKGQLPGG---KAPPKAGSVPSSFLLKKAREPG 153
           L P PG P+ + G   + R+   R +     LPG    +APP A  +P+S  L       
Sbjct: 25  LRPPPGCPQRRLG--ARERRDVQREILAVLGLPGRPRPRAPPAASRLPASAPL------- 75

Query: 154 PPREPKEPFRPPPITPHEYMLSLYRTLSDADRKGGNSSVKLEAGLANTITSFIDKGQDDR 213
                             +ML LY  ++  D + G +  +   G A+ + SF++  + DR
Sbjct: 76  ------------------FMLDLYHAMAGDDDEDG-APAEQRLGRADLVMSFVNMVERDR 116

Query: 214 GPVVRK---QRYVFDISALEK-DGLLGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSCP 269
               ++   + + FD++ +   + +  AE RI +                 +  ++    
Sbjct: 117 ALGHQEPHWKEFRFDLTQIPAGEAVTAAEFRIYKVPSIHLLNRTL----HVSMFQVVQEQ 172

Query: 270 SGRQP-ASLLDVRSVPGLDGSGWEVFDI------WKLFRNFKNSAQLCLELEAWERGRAV 322
           S R+     LD++++   D  GW V D+      W L R+     +L +E E    G +V
Sbjct: 173 SNRESDLFFLDLQTLRAGD-EGWLVLDVTAASDCWLLKRHKDLGLRLYVETED---GHSV 228

Query: 323 D--LRGLGFDRAARQVHEKALFLVFGRTKKRDLFFNEIKARSGQDDKTVYEYLFSQRRKR 380
           D  L GL   RA R   ++   + F R     +                        R  
Sbjct: 229 DPGLAGLLGQRAPRS--QQPFVVTFFRASPSPI------------------------RTP 262

Query: 381 RA--PLATRQGKRPSKNLKAR-----------------CSRKALHVNFKDMGWDDWIIAP 421
           RA  PL  RQ K+ ++  +A                  C R  L+V+F+D+GW DW+IAP
Sbjct: 263 RAVRPLRRRQPKKSNELPQANRLPGIFDDVRGSHGRQVCRRHELYVSFQDLGWLDWVIAP 322

Query: 422 LEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDS 481
             Y A++CEG C FPL S +  TNHA++Q+L++ M P + P  CC PT+LS  S+L+ DS
Sbjct: 323 QGYSAYYCEGECSFPLDSCMNATNHAILQSLVHLMKPNAVPKACCAPTKLSATSVLYYDS 382

Query: 482 ANNVVYKQYEDMVVESCGC 500
           +NNV+ +++ +MVV++CGC
Sbjct: 383 SNNVILRKHRNMVVKACGC 401


>gi|4502425 bone morphogenetic protein 6 preproprotein [Homo
           sapiens]
          Length = 513

 Score =  137 bits (344), Expect = 3e-32
 Identities = 149/546 (27%), Positives = 227/546 (41%), Gaps = 100/546 (18%)

Query: 12  WYLAWLDLEFICTVLGAPDLGQRPQGTRPGLAKAEAKERPPL-ARNVFRPGGHSYGGGAT 70
           W   W  L  +C+  G P L                  RPPL A      GG   G G +
Sbjct: 10  WLCWWWGL--LCSCCGPPPL------------------RPPLPAAAAAAAGGQLLGDGGS 49

Query: 71  NANARAKGGTGQTGG-------LTQPKKDEPKKLPPRPGGPE-PKPGH------PPQTRQ 116
                    + Q+          TQ K++  K++    G P  P+P H      PP  RQ
Sbjct: 50  PGRTEQPPPSPQSSSGFLYRRLKTQEKREMQKEILSVLGLPHRPRPLHGLQQPQPPALRQ 109

Query: 117 ATARTVTPKGQLPGGKAPPKAGSVPSSFLL----------------KKAREPGPPREP-- 158
              +    + QLP G+ PP        F+L                +  R+   P E   
Sbjct: 110 QEEQQ--QQQQLPRGEPPPGRLKSAPLFMLDLYNALSADNDEDGASEGERQQSWPHEAAS 167

Query: 159 -KEPFRPPPITPHEYMLSLYRTLSDADRKGGNS---SVKLEAGL--ANTITSFIDKGQDD 212
             +  +PPP   H   L+    L+     GG S   S +  A L  A+ + SF++  + D
Sbjct: 168 SSQRRQPPPGAAHP--LNRKSLLAPGSGSGGASPLTSAQDSAFLNDADMVMSFVNLVEYD 225

Query: 213 RGPVVRKQR---YVFDISAL-EKDGLLGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSC 268
           +    R++    + F++S + E + +  AE RI +     + K       +   + +   
Sbjct: 226 KEFSPRQRHHKEFKFNLSQIPEGEVVTAAEFRIYKDCVMGSFK------NQTFLISIYQV 279

Query: 269 PSGRQPAS----LLDVRSVPGLDGSGWEVFDIWKLFRNFKNSAQLCLELEAWERGRAVDL 324
               Q       LLD R V   +  GW  FDI         ++ L +       G  + +
Sbjct: 280 LQEHQHRDSDLFLLDTRVVWASE-EGWLEFDITA-------TSNLWVVTPQHNMGLQLSV 331

Query: 325 RGLGFDRAARQVHEKALFLVFGRTKKRD------LFF--NEIKARSGQDDKTVYEYLFSQ 376
                 R    VH +A  LV GR    D       FF  +E+  R+ +   +        
Sbjct: 332 ----VTRDGVHVHPRAAGLV-GRDGPYDKQPFMVAFFKVSEVHVRTTRSASSRRRQQSRN 386

Query: 377 RRKRRAPLA--TRQGKRPSKNLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCE 434
           R  +   +A  +      S  LK  C +  L+V+F+D+GW DWIIAP  Y A +C+G C 
Sbjct: 387 RSTQSQDVARVSSASDYNSSELKTACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECS 446

Query: 435 FPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMV 494
           FPL +H+  TNHA++QTL++ M+PE  P  CC PT+L+ IS+L+ D  +NV+ K+Y +MV
Sbjct: 447 FPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYFDDNSNVILKKYRNMV 506

Query: 495 VESCGC 500
           V +CGC
Sbjct: 507 VRACGC 512


>gi|7656928 bone morphogenetic protein 10 preproprotein [Homo
           sapiens]
          Length = 424

 Score =  132 bits (331), Expect = 1e-30
 Identities = 116/367 (31%), Positives = 167/367 (45%), Gaps = 53/367 (14%)

Query: 167 ITPHEYMLSLYRTLSDADRKGGNSSVKLEAGLANTITSFIDKGQDDRGPV----VRKQRY 222
           + P EYML LY   +  DR    S        AN I SF ++    + PV    +RK   
Sbjct: 79  VDPPEYMLELYNKFA-TDRTSMPS--------ANIIRSFKNEDLFSQ-PVSFNGLRKYPL 128

Query: 223 VFDISALEKDGLLGAELRILRKKPSDTAKPAAPGGGRAAQ----LKLSSCPSGRQPASLL 278
           +F++S    + ++ AELR+      D  +    G  R       L+      G +   +L
Sbjct: 129 LFNVSIPHHEEVIMAELRLYTLVQRD--RMIYDGVDRKITIFEVLESKGDNEGERNMLVL 186

Query: 279 DVRSVPGLDGSGWEVFDIWKLFRNFKNSAQLCLELEAW---ERGRAVDLRG--LGFDRAA 333
               + G + S WE FD+    R ++ S     +LE     +   A D     L  D +A
Sbjct: 187 VSGEIYGTN-SEWETFDVTDAIRRWQKSGSSTHQLEVHIESKHDEAEDASSGRLEIDTSA 245

Query: 334 RQVHEKALFLVFGRTKKRDLFFNEIKARSGQDDKTV-YEYL----------FSQRRKRRA 382
           +  H   L +VF   +  D      K R  + ++ + +E L          FS      A
Sbjct: 246 QNKHNP-LLIVFSDDQSSD------KERKEELNEMISHEQLPELDNLGLDSFSSGPGEEA 298

Query: 383 PLATRQG------KRPSKNLKAR-CSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEF 435
            L  R         R  +N K   C R  L+++FK++GWD WIIAP  YEA+ C G+C +
Sbjct: 299 LLQMRSNIIYDSTARIRRNAKGNYCKRTPLYIDFKEIGWDSWIIAPPGYEAYECRGVCNY 358

Query: 436 PLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYK-QYEDMV 494
           PL  HL PT HA+IQ L++  + +     CCVPT+L PISIL++D    V YK +YE M 
Sbjct: 359 PLAEHLTPTKHAIIQALVHLKNSQKASKACCVPTKLEPISILYLDK-GVVTYKFKYEGMA 417

Query: 495 VESCGCR 501
           V  CGCR
Sbjct: 418 VSECGCR 424


>gi|7705308 growth differentiation factor 2 [Homo sapiens]
          Length = 429

 Score =  119 bits (298), Expect = 6e-27
 Identities = 55/118 (46%), Positives = 73/118 (61%), Gaps = 1/118 (0%)

Query: 385 ATRQGKRPSKNLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPT 444
           +T   ++ S    + C + +L VNF+D+GWD WIIAP EYEA+ C+G C FPL   + PT
Sbjct: 312 STLARRKRSAGAGSHCQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPLADDVTPT 371

Query: 445 NHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYK-QYEDMVVESCGCR 501
            HA++QTL++   P      CCVPT+LSPIS+L+ D       K  YE M V  CGCR
Sbjct: 372 KHAIVQTLVHLKFPTKVGKACCVPTKLSPISVLYKDDMGVPTLKYHYEGMSVAECGCR 429


>gi|10190670 growth differentiation factor 3 precursor [Homo
           sapiens]
          Length = 364

 Score =  119 bits (297), Expect = 8e-27
 Identities = 57/123 (46%), Positives = 79/123 (64%), Gaps = 6/123 (4%)

Query: 378 RKRRAPLATRQGKRPSKNLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPL 437
           RKRRA +       P  + K  C R  L +NF+D+GW  WIIAP  + A +C G C F L
Sbjct: 247 RKRRAAIPV-----PKLSCKNLCHRHQLFINFRDLGWHKWIIAPKGFMANYCHGECPFSL 301

Query: 438 RSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVES 497
              L  +N+A +Q LM+++DPE  P   C+PT+LSPIS+L+ D+ +NV+ + YEDMVV+ 
Sbjct: 302 TISLNSSNYAFMQALMHAVDPE-IPQAVCIPTKLSPISMLYQDNNDNVILRHYEDMVVDE 360

Query: 498 CGC 500
           CGC
Sbjct: 361 CGC 363


>gi|126507087 bone morphogenetic protein 3 preproprotein [Homo
           sapiens]
          Length = 472

 Score =  115 bits (287), Expect = 1e-25
 Identities = 48/103 (46%), Positives = 71/103 (68%), Gaps = 1/103 (0%)

Query: 400 CSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMD-P 458
           C+R+ L V+F D+GW +WII+P  ++A++C G C+FP+   L+P+NHA IQ+++ ++   
Sbjct: 370 CARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVV 429

Query: 459 ESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR 501
              P  CCVP ++S +SILF D   NVV K Y +M VESC CR
Sbjct: 430 PGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR 472


>gi|110349792 growth differentiation factor 1 [Homo sapiens]
          Length = 372

 Score =  110 bits (276), Expect = 2e-24
 Identities = 120/411 (29%), Positives = 167/411 (40%), Gaps = 99/411 (24%)

Query: 128 LPGGKAPPKAGSVPSSFLLKKAREPGPPREPKEPFRPPPITPHEYMLSLYRTLSDADRKG 187
           LP  +AP   G  P++ LL+     G   EP+   R  P+ P   M  L+R     + + 
Sbjct: 24  LPLTRAPVPPG--PAAALLQAL---GLRDEPQGAPRLRPVPP--VMWRLFRRRDPQETRS 76

Query: 188 GNSSVKL----------EAGLANTITSFIDKGQDDRGPVVRKQR------------YVFD 225
           G+               E G+A  I   I     DRG   R                VFD
Sbjct: 77  GSRRTSPGVTLQPCHVEELGVAGNIVRHIP----DRGAPTRASEPASAAGHCPEWTVVFD 132

Query: 226 ISALE---KDGLLGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSCPSGRQPASLLDVRS 282
           +SA+E   +      ELR         A  AAP GG    +  +   +G  P  +L  + 
Sbjct: 133 LSAVEPAERPSRARLELRFA------AAAAAAPEGGWELSVAQAGQGAGADPGPVLLRQL 186

Query: 283 VPGLD--------GSGWEVFDIWKLFRNFKNSAQLCLELEAWERGRAVDLRGLGFDRAAR 334
           VP L         G+ W     W        S +L L L    R RA          A  
Sbjct: 187 VPALGPPVRAELLGAAWARNASWP------RSLRLALAL----RPRA--------PAACA 228

Query: 335 QVHEKALFLVFGRTKKRDLFFNEIKARSGQDDKTVYEYLFSQRRKRRAPLATRQGKRPSK 394
           ++ E +L LV                     D  +   L   RR     L    G     
Sbjct: 229 RLAEASLLLV-------------------TLDPRLCHPLARPRRDAEPVLGGGPG----- 264

Query: 395 NLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLR---SHLEPT-NHAVIQ 450
                C  + L+V+F+++GW  W+IAP  + A +C+G C  P+    S   P  NHAV++
Sbjct: 265 ---GACRARRLYVSFREVGWHRWVIAPRGFLANYCQGQCALPVALSGSGGPPALNHAVLR 321

Query: 451 TLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR 501
            LM++  P +    CCVP RLSPIS+LF D+++NVV +QYEDMVV+ CGCR
Sbjct: 322 ALMHAAAPGAADLPCCVPARLSPISVLFFDNSDNVVLRQYEDMVVDECGCR 372


>gi|4826740 growth differentiation factor 10 precursor [Homo
           sapiens]
          Length = 478

 Score =  109 bits (272), Expect = 7e-24
 Identities = 44/103 (42%), Positives = 71/103 (68%), Gaps = 1/103 (0%)

Query: 400 CSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMD-P 458
           CSR+ L V+F D+GW++WII+P  ++A++C G CEFP+   + P+NHA IQ+++ ++   
Sbjct: 376 CSRRYLKVDFADIGWNEWIISPKSFDAYYCAGACEFPMPKIVRPSNHATIQSIVRAVGII 435

Query: 459 ESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR 501
              P  CCVP +++ + +LF+D   NVV K Y +M V++C CR
Sbjct: 436 PGIPEPCCVPDKMNSLGVLFLDENRNVVLKVYPNMSVDTCACR 478


>gi|4885097 bone morphogenetic protein 15 precursor [Homo sapiens]
          Length = 392

 Score =  107 bits (266), Expect = 3e-23
 Identities = 77/240 (32%), Positives = 113/240 (47%), Gaps = 14/240 (5%)

Query: 269 PSGRQPASLLDVRSVPGLDGSGWEVFDIWKLF--RNFKNSAQLCLELEAWERGRAVDLRG 326
           P+   P+S  D  S P L  + W+  DI +L   R + N     L L    + +  D  G
Sbjct: 160 PTNHFPSSEGD-SSKPSLMSNAWKEMDITQLVQQRFWNNKGHRILRLRFMCQQQK-DSGG 217

Query: 327 LGFDRAARQVHEKALFLVFGRTKKRDLFFNEIKAR---SGQDDKTVYEYLFSQRRKRRAP 383
           L        +    L L F  T K     +  KA+    G ++    E L  + R+    
Sbjct: 218 LELWHGTSSLDIAFLLLYFNDTHK-----SIRKAKFLPRGMEEFMERESLLRRTRQADGI 272

Query: 384 LA--TRQGKRPSKNLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHL 441
            A  T    + S     +CS     ++F+ +GWD WIIAP  Y   +C+G C   LR  L
Sbjct: 273 SAEVTASSSKHSGPENNQCSLHPFQISFRQLGWDHWIIAPPFYTPNYCKGTCLRVLRDGL 332

Query: 442 EPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR 501
              NHA+IQ L+N +  +S P   CVP +  PIS+L I++  +++YK+YE M+ ESC CR
Sbjct: 333 NSPNHAIIQNLINQLVDQSVPRPSCVPYKYVPISVLMIEANGSILYKEYEGMIAESCTCR 392


>gi|222352098 nodal precursor [Homo sapiens]
          Length = 347

 Score =  103 bits (257), Expect = 4e-22
 Identities = 48/130 (36%), Positives = 70/130 (53%), Gaps = 5/130 (3%)

Query: 375 SQRRKRRAPLATRQGKRPSKN----LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCE 430
           S  R +   L+   GKR  ++        C +    V+F  +GW  WII P +Y A+ CE
Sbjct: 218 SSWRAQEGQLSWEWGKRHRRHHLPDRSQLCRKVKFQVDFNLIGWGSWIIYPKQYNAYRCE 277

Query: 431 GLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQY 490
           G C  P+     PTNHA IQ+L+    P   P TCC P +  P+S+L++D+   V+   +
Sbjct: 278 GECPNPVGEEFHPTNHAYIQSLLKRYQPHRVPSTCCAPVKTKPLSMLYVDN-GRVLLDHH 336

Query: 491 EDMVVESCGC 500
           +DM+VE CGC
Sbjct: 337 KDMIVEECGC 346


>gi|4504699 inhibin beta A precursor [Homo sapiens]
          Length = 426

 Score = 92.8 bits (229), Expect = 6e-19
 Identities = 59/187 (31%), Positives = 86/187 (45%), Gaps = 22/187 (11%)

Query: 332 AARQVHEKALFLVFGRTKKRDLFFNEIKARSGQDDKTVYEYLFSQRRKRRAPLATRQGKR 391
           A  Q  E    LV    KK+     E K + G +     +    Q  +    L  RQ + 
Sbjct: 243 ACEQCQESGASLVLLGKKKKKEEEGEGKKKGGGEGGAGADEEKEQSHRPFLMLQARQSED 302

Query: 392 PSKNLKAR----------CSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHL 441
                + R          C +K   V+FKD+GW+DWIIAP  Y A +CEG C     SH+
Sbjct: 303 HPHRRRRRGLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECP----SHI 358

Query: 442 EPTN------HAVI--QTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDM 493
             T+      H+ +     M    P +   +CCVPT+L P+S+L+ D   N++ K  ++M
Sbjct: 359 AGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNM 418

Query: 494 VVESCGC 500
           +VE CGC
Sbjct: 419 IVEECGC 425


>gi|13899338 activin beta E [Homo sapiens]
          Length = 350

 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 44/126 (34%), Positives = 69/126 (54%), Gaps = 10/126 (7%)

Query: 377 RRKRRAPLATRQGKRPSKNLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFP 436
           R +RR P        P+  L   C R+  +V+F+++GW DWI+ P  Y+  +C G C   
Sbjct: 232 RARRRTPTC-----EPATPL---CCRRDHYVDFQELGWRDWILQPEGYQLNYCSGQCPPH 283

Query: 437 LRSH--LEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMV 494
           L     +  + H+ + +L+ + +P     +CCVPT   P+S+L++D   NVV     DMV
Sbjct: 284 LAGSPGIAASFHSAVFSLLKANNPWPASTSCCVPTARRPLSLLYLDHNGNVVKTDVPDMV 343

Query: 495 VESCGC 500
           VE+CGC
Sbjct: 344 VEACGC 349


>gi|4885259 myostatin [Homo sapiens]
          Length = 375

 Score = 83.6 bits (205), Expect = 4e-16
 Identities = 39/104 (37%), Positives = 60/104 (57%), Gaps = 7/104 (6%)

Query: 397 KARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSM 456
           ++RC R  L V+F+  GWD WIIAP  Y+A +C G CEF        T+      L++  
Sbjct: 278 ESRCCRYPLTVDFEAFGWD-WIIAPKRYKANYCSGECEFVFLQKYPHTH------LVHQA 330

Query: 457 DPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGC 500
           +P  +   CC PT++SPI++L+ +    ++Y +   MVV+ CGC
Sbjct: 331 NPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGC 374


>gi|5031613 growth differentiation factor 11 precursor [Homo
           sapiens]
          Length = 407

 Score = 83.2 bits (204), Expect = 5e-16
 Identities = 38/104 (36%), Positives = 59/104 (56%), Gaps = 7/104 (6%)

Query: 397 KARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSM 456
           ++RC R  L V+F+  GWD WIIAP  Y+A +C G CE+        T+      L+   
Sbjct: 310 ESRCCRYPLTVDFEAFGWD-WIIAPKRYKANYCSGQCEYMFMQKYPHTH------LVQQA 362

Query: 457 DPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGC 500
           +P  +   CC PT++SPI++L+ +    ++Y +   MVV+ CGC
Sbjct: 363 NPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGC 406


>gi|4885261 growth differentiation factor 9 precursor [Homo sapiens]
          Length = 454

 Score = 80.1 bits (196), Expect = 4e-15
 Identities = 33/102 (32%), Positives = 53/102 (51%)

Query: 400 CSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPE 459
           C      ++F  + WD+WI+AP  Y   +C+G C   +        H ++Q ++      
Sbjct: 353 CELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYEKLDS 412

Query: 460 STPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR 501
           S P   CVP + SP+S+L I+   ++ YK+YEDM+   C CR
Sbjct: 413 SVPRPSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTCR 454


>gi|154813204 inhibin beta B subunit preproprotein [Homo sapiens]
          Length = 407

 Score = 80.1 bits (196), Expect = 4e-15
 Identities = 40/105 (38%), Positives = 61/105 (58%), Gaps = 5/105 (4%)

Query: 400 CSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRS---HLEPTNHAVI-QTLMNS 455
           C R+   ++F+ +GW+DWIIAP  Y   +CEG C   L          + AV+ Q  M  
Sbjct: 303 CCRQQFFIDFRLIGWNDWIIAPTGYYGNYCEGSCPAYLAGVPGSASSFHTAVVNQYRMRG 362

Query: 456 MDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGC 500
           ++P  T  +CC+PT+LS +S+L+ D   N+V +   +M+VE CGC
Sbjct: 363 LNP-GTVNSCCIPTKLSTMSMLYFDDEYNIVKRDVPNMIVEECGC 406


>gi|5031795 inhibin beta C chain preproprotein [Homo sapiens]
          Length = 352

 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 37/105 (35%), Positives = 55/105 (52%), Gaps = 4/105 (3%)

Query: 400 CSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSH--LEPTNHAVIQTLMNSMD 457
           C R+   V+F+++GW DWII P  Y    C G C   +     +  + H  +  L+ +  
Sbjct: 247 CCRQEFFVDFREIGWHDWIIQPEGYAMNFCIGQCPLHIAGMPGIAASFHTAVLNLLKANT 306

Query: 458 PESTPP--TCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGC 500
              T    +CCVPT   P+S+L+ D  +N+V     DMVVE+CGC
Sbjct: 307 AAGTTGGGSCCVPTARRPLSLLYYDRDSNIVKTDIPDMVVEACGC 351


>gi|4507465 transforming growth factor, beta 3 [Homo sapiens]
          Length = 412

 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 40/108 (37%), Positives = 63/108 (58%), Gaps = 6/108 (5%)

Query: 394 KNLKARCSRKALHVNFK-DMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTL 452
           +NL+  C  + L+++F+ D+GW  W+  P  Y A  C G C + LRS    T H+ +  L
Sbjct: 309 RNLEENCCVRPLYIDFRQDLGWK-WVHEPKGYYANFCSGPCPY-LRS--ADTTHSTVLGL 364

Query: 453 MNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGC 500
            N+++PE++   CCVP  L P++IL+       V +Q  +MVV+SC C
Sbjct: 365 YNTLNPEASASPCCVPQDLEPLTILYYVGRTPKV-EQLSNMVVKSCKC 411


>gi|208022653 transforming growth factor, beta 2 isoform 1 [Homo
           sapiens]
          Length = 442

 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 42/127 (33%), Positives = 69/127 (54%), Gaps = 10/127 (7%)

Query: 375 SQRRKRRAPLATRQGKRPSKNLKARCSRKALHVNFK-DMGWDDWIIAPLEYEAFHCEGLC 433
           + RRK+RA  A        +N++  C  + L+++FK D+GW  WI  P  Y A  C G C
Sbjct: 324 TNRRKKRALDAAYC----FRNVQDNCCLRPLYIDFKRDLGWK-WIHEPKGYNANFCAGAC 378

Query: 434 EFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDM 493
            +   S    T H+ + +L N+++PE++   CCV   L P++IL+       + +Q  +M
Sbjct: 379 PYLWSSD---TQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKI-EQLSNM 434

Query: 494 VVESCGC 500
           +V+SC C
Sbjct: 435 IVKSCKC 441


>gi|4507463 transforming growth factor, beta 2 isoform 2 [Homo
           sapiens]
          Length = 414

 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 42/127 (33%), Positives = 69/127 (54%), Gaps = 10/127 (7%)

Query: 375 SQRRKRRAPLATRQGKRPSKNLKARCSRKALHVNFK-DMGWDDWIIAPLEYEAFHCEGLC 433
           + RRK+RA  A        +N++  C  + L+++FK D+GW  WI  P  Y A  C G C
Sbjct: 296 TNRRKKRALDAAYC----FRNVQDNCCLRPLYIDFKRDLGWK-WIHEPKGYNANFCAGAC 350

Query: 434 EFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDM 493
            +   S    T H+ + +L N+++PE++   CCV   L P++IL+       + +Q  +M
Sbjct: 351 PYLWSSD---TQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKI-EQLSNM 406

Query: 494 VVESCGC 500
           +V+SC C
Sbjct: 407 IVKSCKC 413


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.137    0.425 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,532,187
Number of Sequences: 37866
Number of extensions: 1490567
Number of successful extensions: 12345
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 128
Number of HSP's successfully gapped in prelim test: 786
Number of HSP's that attempted gapping in prelim test: 8710
Number of HSP's gapped (non-prelim): 3302
length of query: 501
length of database: 18,247,518
effective HSP length: 106
effective length of query: 395
effective length of database: 14,233,722
effective search space: 5622320190
effective search space used: 5622320190
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.