Search of human proteins with 4503825

Search of human proteins with 4503825

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4503825 frizzled 1 [Homo sapiens]
         (647 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4503825 frizzled 1 [Homo sapiens]                                 1352   0.0  
gi|4503833 frizzled 7 [Homo sapiens]                                  919   0.0  
gi|4503827 frizzled 2 [Homo sapiens]                                  919   0.0  
gi|27894385 frizzled 5 precursor [Homo sapiens]                       520   e-147
gi|13994190 frizzled 8 [Homo sapiens]                                 508   e-144
gi|6005762 frizzled 10 [Homo sapiens]                                 498   e-141
gi|8393378 frizzled 3 [Homo sapiens]                                  482   e-136
gi|34734079 frizzled 6 [Homo sapiens]                                 461   e-130
gi|4503835 frizzled 9 [Homo sapiens]                                  447   e-125
gi|22547161 frizzled 4 [Homo sapiens]                                 446   e-125
gi|5032099 smoothened [Homo sapiens]                                  193   5e-49
gi|38455388 frizzled-related protein [Homo sapiens]                   124   4e-28
gi|170784838 secreted frizzled-related  protein 4 [Homo sapiens]      120   4e-27
gi|48475052 secreted frizzled-related protein 2 precursor [Homo ...   104   2e-22
gi|188528609 secreted frizzled-related protein 5 [Homo sapiens]       103   4e-22
gi|56117838 secreted frizzled-related protein 1 [Homo sapiens]        103   5e-22
gi|29244926 corin [Homo sapiens]                                       96   1e-19
gi|13899255 membrane frizzled-related protein [Homo sapiens]           76   8e-14
gi|62388877 carboxypeptidase Z isoform 1 [Homo sapiens]                64   3e-10
gi|62388875 carboxypeptidase Z isoform 2 precursor [Homo sapiens]      63   7e-10
gi|206597445 alpha 1 type XVIII collagen isoform 3 precursor [Ho...    48   2e-05
gi|239751080 PREDICTED: hypothetical protein XP_002347700 [Homo ...    43   8e-04
gi|239745567 PREDICTED: hypothetical protein XP_002344149 [Homo ...    43   8e-04
gi|122937267 lemur tyrosine kinase 3 [Homo sapiens]                    37   0.043
gi|59806361 hypothetical protein LOC387104 [Homo sapiens]              37   0.074
gi|66882532 farnesyltransferase, CAAX box, alpha isoform c [Homo...    37   0.074
gi|4503771 farnesyltransferase, CAAX box, alpha isoform a [Homo ...    37   0.074
gi|208022661 hypothetical protein LOC57701 [Homo sapiens]              37   0.074
gi|110832843 TBP-associated factor 4 [Homo sapiens]                    35   0.16 
gi|192807323 SWI/SNF-related matrix-associated actin-dependent r...    35   0.22 

>gi|4503825 frizzled 1 [Homo sapiens]
          Length = 647

 Score = 1352 bits (3500), Expect = 0.0
 Identities = 647/647 (100%), Positives = 647/647 (100%)

Query: 1   MAEEEAPKKSRAAGGGASWELCAGALSARLAEEGSGDAGGRRRPPVDPRRLARQLLLLLW 60
           MAEEEAPKKSRAAGGGASWELCAGALSARLAEEGSGDAGGRRRPPVDPRRLARQLLLLLW
Sbjct: 1   MAEEEAPKKSRAAGGGASWELCAGALSARLAEEGSGDAGGRRRPPVDPRRLARQLLLLLW 60

Query: 61  LLEAPLLLGVRAQAAGQGPGQGPGPGQQPPPPPQQQQSGQQYNGERGISVPDHGYCQPIS 120
           LLEAPLLLGVRAQAAGQGPGQGPGPGQQPPPPPQQQQSGQQYNGERGISVPDHGYCQPIS
Sbjct: 61  LLEAPLLLGVRAQAAGQGPGQGPGPGQQPPPPPQQQQSGQQYNGERGISVPDHGYCQPIS 120

Query: 121 IPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAPVCTVL 180
           IPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAPVCTVL
Sbjct: 121 IPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAPVCTVL 180

Query: 181 EQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFPVHGAGELCVGQNTSDKGTPTP 240
           EQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFPVHGAGELCVGQNTSDKGTPTP
Sbjct: 181 EQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFPVHGAGELCVGQNTSDKGTPTP 240

Query: 241 SLLPEFWTSNPQHGGGGHRGGFPGGAGASERGKFSCPRALKVPSYLNYHFLGEKDCGAPC 300
           SLLPEFWTSNPQHGGGGHRGGFPGGAGASERGKFSCPRALKVPSYLNYHFLGEKDCGAPC
Sbjct: 241 SLLPEFWTSNPQHGGGGHRGGFPGGAGASERGKFSCPRALKVPSYLNYHFLGEKDCGAPC 300

Query: 301 EPTKVYGLMYFGPEELRFSRTWIGIWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSG 360
           EPTKVYGLMYFGPEELRFSRTWIGIWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSG
Sbjct: 301 EPTKVYGLMYFGPEELRFSRTWIGIWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSG 360

Query: 361 CYTAVAVAYIAGFLLEDRVVCNDKFAEDGARTVAQGTKKEGCTILFMMLYFFSMASSIWW 420
           CYTAVAVAYIAGFLLEDRVVCNDKFAEDGARTVAQGTKKEGCTILFMMLYFFSMASSIWW
Sbjct: 361 CYTAVAVAYIAGFLLEDRVVCNDKFAEDGARTVAQGTKKEGCTILFMMLYFFSMASSIWW 420

Query: 421 VILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILALGQVDGDVLSGVCFVG 480
           VILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILALGQVDGDVLSGVCFVG
Sbjct: 421 VILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILALGQVDGDVLSGVCFVG 480

Query: 481 LNNVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVF 540
           LNNVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVF
Sbjct: 481 LNNVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVF 540

Query: 541 SVLYTVPATIVIACYFYEQAFRDQWERSWVAQSCKSYAIPCPHLQAGGGAPPHPPMSPDF 600
           SVLYTVPATIVIACYFYEQAFRDQWERSWVAQSCKSYAIPCPHLQAGGGAPPHPPMSPDF
Sbjct: 541 SVLYTVPATIVIACYFYEQAFRDQWERSWVAQSCKSYAIPCPHLQAGGGAPPHPPMSPDF 600

Query: 601 TVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRLTNSKQGETTV 647
           TVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRLTNSKQGETTV
Sbjct: 601 TVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRLTNSKQGETTV 647


>gi|4503833 frizzled 7 [Homo sapiens]
          Length = 574

 Score =  919 bits (2375), Expect = 0.0
 Identities = 443/560 (79%), Positives = 484/560 (86%), Gaps = 30/560 (5%)

Query: 100 QQYNGERGISVPDHGYCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKV 159
           Q Y+GE+GISVPDHG+CQPISIPLCTDIAYNQTI+PNLLGHTNQEDAGLEVHQFYPLVKV
Sbjct: 33  QPYHGEKGISVPDHGFCQPISIPLCTDIAYNQTILPNLLGHTNQEDAGLEVHQFYPLVKV 92

Query: 160 QCSAELKFFLCSMYAPVCTVLEQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFP 219
           QCS EL+FFLCSMYAPVCTVL+QA+PPCRSLCERARQGCEALMNKFGFQWP+ L+CE FP
Sbjct: 93  QCSPELRFFLCSMYAPVCTVLDQAIPPCRSLCERARQGCEALMNKFGFQWPERLRCENFP 152

Query: 220 VHGAGELCVGQNTSD---------KGTPTPSLLPE--FWTSNPQHGGGGHRGGFPGGAGA 268
           VHGAGE+CVGQNTSD            PT   LP+  F    P    G  R  FP     
Sbjct: 153 VHGAGEICVGQNTSDGSGGPGGGPTAYPTAPYLPDLPFTALPPGASDGRGRPAFP----- 207

Query: 269 SERGKFSCPRALKVPSYLNYHFLGEKDCGAPCEPTKVYGLMYFGPEELRFSRTWIGIWSV 328
                FSCPR LKVP YL Y FLGE+DCGAPCEP +  GLMYF  EE RF+R W+G+WSV
Sbjct: 208 -----FSCPRQLKVPPYLGYRFLGERDCGAPCEPGRANGLMYFKEEERRFARLWVGVWSV 262

Query: 329 LCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYTAVAVAYIAGFLLEDRVVCNDKFAED 388
           LCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCY  VAVA++AGFLLEDR VC ++F++D
Sbjct: 263 LCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVAVAHVAGFLLEDRAVCVERFSDD 322

Query: 389 GARTVAQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFH 448
           G RTVAQGTKKEGCTILFM+LYFF MASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFH
Sbjct: 323 GYRTVAQGTKKEGCTILFMVLYFFGMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFH 382

Query: 449 LAAWAVPAIKTITILALGQVDGDVLSGVCFVGLNNVDALRGFVLAPLFVYLFIGTSFLLA 508
           LAAWAVPA+KTITILA+GQVDGD+LSGVC+VGL++VDALRGFVLAPLFVYLFIGTSFLLA
Sbjct: 383 LAAWAVPAVKTITILAMGQVDGDLLSGVCYVGLSSVDALRGFVLAPLFVYLFIGTSFLLA 442

Query: 509 GFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFRDQWERS 568
           GFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIV+ACYFYEQAFR+ WER+
Sbjct: 443 GFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVLACYFYEQAFREHWERT 502

Query: 569 WVAQSCKSYAIPCPHLQAGGGAPPH-PPMSPDFTVFMIKYLMTLIVGITSGFWIWSGKTL 627
           W+ Q+CKSYA+PCP        P H PPMSPDFTVFMIKYLMT+IVGIT+GFWIWSGKTL
Sbjct: 503 WLLQTCKSYAVPCP--------PGHFPPMSPDFTVFMIKYLMTMIVGITTGFWIWSGKTL 554

Query: 628 NSWRKFYTRLTNSKQGETTV 647
            SWR+FY RL++S +GET V
Sbjct: 555 QSWRRFYHRLSHSSKGETAV 574


>gi|4503827 frizzled 2 [Homo sapiens]
          Length = 565

 Score =  919 bits (2374), Expect = 0.0
 Identities = 444/552 (80%), Positives = 483/552 (87%), Gaps = 15/552 (2%)

Query: 101 QYNGERGISVPDHGYCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQ 160
           Q++GE+GIS+PDHG+CQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQ
Sbjct: 24  QFHGEKGISIPDHGFCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQ 83

Query: 161 CSAELKFFLCSMYAPVCTVLEQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFPV 220
           CS EL+FFLCSMYAPVCTVLEQA+PPCRS+CERARQGCEALMNKFGFQWP+ L+CE FP 
Sbjct: 84  CSPELRFFLCSMYAPVCTVLEQAIPPCRSICERARQGCEALMNKFGFQWPERLRCEHFPR 143

Query: 221 HGAGELCVGQNTSDKGTPTPSLLPEFWTSNPQHGGGGHRGGFPGGAGASER-----GKFS 275
           HGA ++CVGQN S+ G P  +LL        Q G GG  GG PGG GA  R       F 
Sbjct: 144 HGAEQICVGQNHSEDGAP--ALLTTAPPPGLQPGAGGTPGG-PGGGGAPPRYATLEHPFH 200

Query: 276 CPRALKVPSYLNYHFLGEKDCGAPCEPTKVYGLMYFGPEELRFSRTWIGIWSVLCCASTL 335
           CPR LKVPSYL+Y FLGE+DC APCEP +  G M+F  EE RF+R WI  WSVLCCAST 
Sbjct: 201 CPRVLKVPSYLSYKFLGERDCAAPCEPARPDGSMFFSQEETRFARLWILTWSVLCCASTF 260

Query: 336 FTVLTYLVDMRRFSYPERPIIFLSGCYTAVAVAYIAGFLLEDRVVCNDKFAEDGARTVAQ 395
           FTV TYLVDM+RF YPERPIIFLSGCYT V+VAYIAGF+L++RVVCN++F+EDG RTV Q
Sbjct: 261 FTVTTYLVDMQRFRYPERPIIFLSGCYTMVSVAYIAGFVLQERVVCNERFSEDGYRTVVQ 320

Query: 396 GTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVP 455
           GTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVP
Sbjct: 321 GTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVP 380

Query: 456 AIKTITILALGQVDGDVLSGVCFVGLNNVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFR 515
           A+KTITILA+GQ+DGD+LSGVCFVGLN++D LRGFVLAPLFVYLFIGTSFLLAGFVSLFR
Sbjct: 381 AVKTITILAMGQIDGDLLSGVCFVGLNSLDPLRGFVLAPLFVYLFIGTSFLLAGFVSLFR 440

Query: 516 IRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFRDQWERSWVAQSCK 575
           IRTIMKHDGTKTEKLE+LMVRIGVFSVLYTVPATIVIACYFYEQAFR+ WERSWV+Q CK
Sbjct: 441 IRTIMKHDGTKTEKLERLMVRIGVFSVLYTVPATIVIACYFYEQAFREHWERSWVSQHCK 500

Query: 576 SYAIPCPHLQAGGGAPPHPPMSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYT 635
           S AIPCP       A   P MSPDFTV+MIKYLMTLIVGITSGFWIWSGKTL+SWRKFYT
Sbjct: 501 SLAIPCP-------AHYTPRMSPDFTVYMIKYLMTLIVGITSGFWIWSGKTLHSWRKFYT 553

Query: 636 RLTNSKQGETTV 647
           RLTNS+ GETTV
Sbjct: 554 RLTNSRHGETTV 565


>gi|27894385 frizzled 5 precursor [Homo sapiens]
          Length = 585

 Score =  520 bits (1339), Expect = e-147
 Identities = 268/534 (50%), Positives = 345/534 (64%), Gaps = 43/534 (8%)

Query: 116 CQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAP 175
           CQ I++P+C  I YN T MPN   H  Q++AGLEVHQF+PLV++QCS +L+FFLCSMY P
Sbjct: 33  CQEITVPMCRGIGYNLTHMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLRFFLCSMYTP 92

Query: 176 VCTV-LEQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFPVHG--AGELCVGQNT 232
           +C     + LPPCRS+CERA+ GC  LM ++GF WP+ + C++ PV G  A  LC+  N 
Sbjct: 93  ICLPDYHKPLPPCRSVCERAKAGCSPLMRQYGFAWPERMSCDRLPVLGRDAEVLCMDYNR 152

Query: 233 SDKGTPTPSLLPEFWTSNPQHGGGGHRGGFPGGAGASERGKFSCP-RALKVPSYLNYHFL 291
           S+  T  P   P   T     G     G  P G      G F C  R   VP     H L
Sbjct: 153 SEATTAPPRPFPAKPTLPGPPGAPASGGECPAG------GPFVCKCREPFVPILKESHPL 206

Query: 292 GEK-------DCGAPC-EPTKVYGLMYFGPEELRFSRTWIGIWSVLCCASTLFTVLTYLV 343
             K       +C  PC +P+       F  +E  F+  WIG+WSVLC  ST  TV T+L+
Sbjct: 207 YNKVRTGQVPNCAVPCYQPS-------FSADERTFATFWIGLWSVLCFISTSTTVATFLI 259

Query: 344 DMRRFSYPERPIIFLSGCYTAVAVAYIAGFLL-EDRVVCNDKFAEDGARTVAQGTKKEGC 402
           DM RF YPERPIIFLS CY  V++ ++   ++    V C+ +       T         C
Sbjct: 260 DMERFRYPERPIIFLSACYLCVSLGFLVRLVVGHASVACSREHNHIHYETTGPAL----C 315

Query: 403 TILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITI 462
           TI+F+++YFF MASSIWWVILSLTWFLAAGMKWG+EAI   +QYFHLAAW +P++K+IT 
Sbjct: 316 TIVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYAQYFHLAAWLIPSVKSITA 375

Query: 463 LALGQVDGDVLSGVCFVGLNNVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKH 522
           LAL  VDGD ++G+C+VG  N+++LRGFVL PL +YL +GT FLLAGFVSLFRIR+++K 
Sbjct: 376 LALSSVDGDPVAGICYVGNQNLNSLRGFVLGPLVLYLLVGTLFLLAGFVSLFRIRSVIKQ 435

Query: 523 DGTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFRDQWERSWVAQSCKSYAIPCP 582
            GTKT+KLEKLM+RIG+F++LYTVPA+IV+ACY YEQ +R+ WE    A +C      CP
Sbjct: 436 GGTKTDKLEKLMIRIGIFTLLYTVPASIVVACYLYEQHYRESWE---AALTC-----ACP 487

Query: 583 HLQAGGGAPPHPPMSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTR 636
               G      P   P++ V M+KY M L+VGITSG WIWSGKT+ SWR+F +R
Sbjct: 488 GHDTG-----QPRAKPEYWVLMLKYFMCLVVGITSGVWIWSGKTVESWRRFTSR 536


>gi|13994190 frizzled 8 [Homo sapiens]
          Length = 694

 Score =  508 bits (1308), Expect = e-144
 Identities = 284/611 (46%), Positives = 355/611 (58%), Gaps = 102/611 (16%)

Query: 116 CQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAP 175
           CQ I++PLC  I YN T MPN   H  Q++AGLEVHQF+PLV++QCS +LKFFLCSMY P
Sbjct: 35  CQEITVPLCKGIGYNYTYMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLKFFLCSMYTP 94

Query: 176 VCTV-LEQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFPVHGAGE-LCVGQNTS 233
           +C    ++ LPPCRS+CERA+ GC  LM ++GF WPD ++C++ P  G  + LC+  N +
Sbjct: 95  ICLEDYKKPLPPCRSVCERAKAGCAPLMRQYGFAWPDRMRCDRLPEQGNPDTLCMDYNRT 154

Query: 234 DKGTPTPS----LLPEFWTSNPQHGGGG---------HRGGFPGGAGASER--------- 271
           D  T  PS    L P      P  G G          HRGG  GG G             
Sbjct: 155 DLTTAAPSPPRRLPPPPPGEQPPSGSGHGRPPGARPPHRGGGRGGGGGDAAAPPARGGGG 214

Query: 272 -GKFSCP-------------RALKVPSYLNYHFLGEK-------DCGAPCEPTKVYGLMY 310
            GK   P             RA  V      H L  +       +C  PC         +
Sbjct: 215 GGKARPPGGGAAPCEPGCQCRAPMVSVSSERHPLYNRVKTGQIANCALPCHNP------F 268

Query: 311 FGPEELRFSRTWIGIWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYTAVAVAYI 370
           F  +E  F+  WIG+WSVLC  ST  TV T+L+DM RF YPERPIIFLS CY  V+V Y+
Sbjct: 269 FSQDERAFTVFWIGLWSVLCFVSTFATVSTFLIDMERFKYPERPIIFLSACYLFVSVGYL 328

Query: 371 AGFLL-EDRVVCNDKF-----------AEDGARTVAQGTKKEG----------------- 401
              +   ++V C+              A  GA     G    G                 
Sbjct: 329 VRLVAGHEKVACSGGAPGAGGAGGAGGAAAGAGAAGAGAGGPGGRGEYEELGAVEQHVRY 388

Query: 402 -------CTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAV 454
                  CT++F+++YFF MASSIWWVILSLTWFLAAGMKWG+EAI   SQYFHLAAW V
Sbjct: 389 ETTGPALCTVVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYSQYFHLAAWLV 448

Query: 455 PAIKTITILALGQVDGDVLSGVCFVGLNNVDALRGFVLAPLFVYLFIGTSFLLAGFVSLF 514
           P++K+I +LAL  VDGD ++G+C+VG  ++D LRGFVLAPL +YLFIGT FLLAGFVSLF
Sbjct: 449 PSVKSIAVLALSSVDGDPVAGICYVGNQSLDNLRGFVLAPLVIYLFIGTMFLLAGFVSLF 508

Query: 515 RIRTIMK-HDG-TKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFRDQWERSWVAQ 572
           RIR+++K  DG TKT KLEKLM+R+G+F+VLYTVPA +V+AC FYEQ  R +WE +    
Sbjct: 509 RIRSVIKQQDGPTKTHKLEKLMIRLGLFTVLYTVPAAVVVACLFYEQHNRPRWEATH--- 565

Query: 573 SCKSYAIPCPHLQAGGGAPPHPPMSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRK 632
                   CP L+      P     PD+ VFM+KY M L+VGITSG W+WSGKTL SWR 
Sbjct: 566 -------NCPCLR---DLQPDQARRPDYAVFMLKYFMCLVVGITSGVWVWSGKTLESWRS 615

Query: 633 FYTRLTNSKQG 643
             TR   + +G
Sbjct: 616 LCTRCCWASKG 626


>gi|6005762 frizzled 10 [Homo sapiens]
          Length = 581

 Score =  498 bits (1282), Expect = e-141
 Identities = 262/543 (48%), Positives = 336/543 (61%), Gaps = 41/543 (7%)

Query: 111 PDHGYCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLC 170
           P  G CQPI IP+C DI YN T MPNL+GH NQ +A +++H+F PLV+  C   L+FFLC
Sbjct: 29  PGDGKCQPIEIPMCKDIGYNMTRMPNLMGHENQREAAIQLHEFAPLVEYGCHGHLRFFLC 88

Query: 171 SMYAPVCTV-LEQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFP-VHGAGELCV 228
           S+YAP+CT  +   +P CR +CE+AR  C  +M +F F+WPD+L C K P  +    LC+
Sbjct: 89  SLYAPMCTEQVSTPIPACRVMCEQARLKCSPIMEQFNFKWPDSLDCRKLPNKNDPNYLCM 148

Query: 229 G--QNTSDKGTPTPSLLPEFWTSNPQHGGGGH--RGGFPGGAGASERGKFSCPRALKVPS 284
               N SD+ T    L P  +     H    H  + G PG  G    GKF          
Sbjct: 149 EAPNNGSDEPTRGSGLFPPLFRPQRPHSAQEHPLKDGGPGRGGCDNPGKF---------- 198

Query: 285 YLNYHFLGEKDCGAPCEPTKVYGL-MYFGPEELRFSRTWIGIWSVLCCASTLFTVLTYLV 343
              +H      C   C P    G+ +Y+  E+ RF+  W+ IW+VLC  S+ FTVLT+L+
Sbjct: 199 ---HHVEKSASCAPLCTP----GVDVYWSREDKRFAVVWLAIWAVLCFFSSAFTVLTFLI 251

Query: 344 DMRRFSYPERPIIFLSGCYTAVAVAYIAGFLLEDRVVCNDKFAEDGARTVAQ-GTKKEGC 402
           D  RF YPERPIIFLS CY   +V Y+         +  D+  + G   V Q G +  GC
Sbjct: 252 DPARFRYPERPIIFLSMCYCVYSVGYLIRLFAGAESIACDR--DSGQLYVIQEGLESTGC 309

Query: 403 TILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITI 462
           T++F++LY+F MASS+WWV+L+LTWFLAAG KWGHEAIEANS YFHLAAWA+PA+KTI I
Sbjct: 310 TLVFLVLYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEANSSYFHLAAWAIPAVKTILI 369

Query: 463 LALGQVDGDVLSGVCFVGLNNVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKH 522
           L + +V GD L+GVC+VG  +V+AL GFVL PL  YL IGTSF+L+GFV+LF IR +MK 
Sbjct: 370 LVMRRVAGDELTGVCYVGSMDVNALTGFVLIPLACYLVIGTSFILSGFVALFHIRRVMKT 429

Query: 523 DGTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFRDQWERSWVAQSCK----SYA 578
            G  T+KLEKLMVRIG+FSVLYTVPAT VIACYFYE+   D W+       CK    +  
Sbjct: 430 GGENTDKLEKLMVRIGLFSVLYTVPATCVIACYFYERLNMDYWKILAAQHKCKMNNQTKT 489

Query: 579 IPCPHLQAGGGAPPHPPMSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRLT 638
           + C  L A           P   +FM+K  M L+VGITSG WIW+ KTL SW++  +R  
Sbjct: 490 LDC--LMAAS--------IPAVEIFMVKIFMLLVVGITSGMWIWTSKTLQSWQQVCSRRL 539

Query: 639 NSK 641
             K
Sbjct: 540 KKK 542


>gi|8393378 frizzled 3 [Homo sapiens]
          Length = 666

 Score =  482 bits (1240), Expect = e-136
 Identities = 239/520 (45%), Positives = 319/520 (61%), Gaps = 37/520 (7%)

Query: 116 CQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAP 175
           C+PI++ +C D+ YN T MPNLL H +Q+ A L +  F+P+V + CS + + FLC++YAP
Sbjct: 28  CEPITLRMCQDLPYNTTFMPNLLNHYDQQTAALAMEPFHPMVNLDCSRDFRPFLCALYAP 87

Query: 176 VCTVLEQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFPVHGAGELCVGQNTSDK 235
           +C    +   PCR LC+RA   C  LM  FG  WP+ ++C +FP              D 
Sbjct: 88  ICMEYGRVTLPCRRLCQRAYSECSKLMEMFGVPWPEDMECSRFP--------------DC 133

Query: 236 GTPTPSLLPEFWTSNPQHGGGGHRGGFPGGAGASERGKFSCPRALKVPSYLNYHFLGEKD 295
             P P L+       P  G                   F CPR LK+   L Y FL  +D
Sbjct: 134 DEPYPRLVDLNLAGEPTEGAP---------VAVQRDYGFWCPRELKIDPDLGYSFLHVRD 184

Query: 296 CGAPCEPTKVYGLMYFGPEELRFSRTWIGIWSVLCCASTLFTVLTYLVDMRRFSYPERPI 355
           C  PC        MYF  EEL F+R +IG+ S++C ++TLFT LT+L+D+ RF YPERPI
Sbjct: 185 CSPPCPN------MYFRREELSFARYFIGLISIICLSATLFTFLTFLIDVTRFRYPERPI 238

Query: 356 IFLSGCYTAVAVAYIAGFLLEDRVVCNDKF-AEDGARTVAQGTKKEGCTILFMMLYFFSM 414
           IF + CY  V++ +  GFLLEDRV CN    A+  A TV QG+  + CT+LFM+LYFF+M
Sbjct: 239 IFYAVCYMMVSLIFFIGFLLEDRVACNASIPAQYKASTVTQGSHNKACTMLFMILYFFTM 298

Query: 415 ASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILALGQVDGDVLS 474
           A S+WWVIL++TWFLAA  KWG EAIE  +  FH +AW +P   TI +LA+ +++GD +S
Sbjct: 299 AGSVWWVILTITWFLAAVPKWGSEAIEKKALLFHASAWGIPGTLTIILLAMNKIEGDNIS 358

Query: 475 GVCFVGLNNVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLM 534
           GVCFVGL +VDALR FVLAPL +Y+ +G S LLAG +SL R+R  +  +    +KL K M
Sbjct: 359 GVCFVGLYDVDALRYFVLAPLCLYVVVGVSLLLAGIISLNRVRIEIPLEKENQDKLVKFM 418

Query: 535 VRIGVFSVLYTVPATIVIACYFYEQAFRDQWERSWVAQSCKSYAIPCPHLQAGGGAPPHP 594
           +RIGVFS+LY VP  +VI CYFYEQA+R  WE +W+ + C+ Y IPCP+           
Sbjct: 419 IRIGVFSILYLVPLLVVIGCYFYEQAYRGIWETTWIQERCREYHIPCPYQVT-------Q 471

Query: 595 PMSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFY 634
              PD  +F++KYLM LIVGI S FW+ S KT   W  F+
Sbjct: 472 MSRPDLILFLMKYLMALIVGIPSVFWVGSKKTCFEWASFF 511


>gi|34734079 frizzled 6 [Homo sapiens]
          Length = 706

 Score =  461 bits (1186), Expect = e-130
 Identities = 233/523 (44%), Positives = 315/523 (60%), Gaps = 39/523 (7%)

Query: 116 CQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAP 175
           C+PI++P C  +AYN T  PNL+GH +Q  A +E+  F PL  ++CS  ++ FLC  + P
Sbjct: 24  CEPITVPRCMKMAYNMTFFPNLMGHYDQSIAAVEMEHFLPLANLECSPNIETFLCKAFVP 83

Query: 176 VCTVLEQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFPVHGAGELCVGQNTSDK 235
            C      +PPCR LCE+    C+ L++ FG +WP+ L+C++       + C        
Sbjct: 84  TCIEQIHVVPPCRKLCEKVYSDCKKLIDTFGIRWPEELECDRL------QYCDETVPVTF 137

Query: 236 GTPTPSLLPEFWTSNPQHGGGGHRGGFPGGAGASERGKFSCPRALKVPSYLNYHFLGEKD 295
              T  L P+  T   Q   G                 F CPR LK      Y FLG   
Sbjct: 138 DPHTEFLGPQKKTEQVQRDIG-----------------FWCPRHLKTSGGQGYKFLGIDQ 180

Query: 296 CGAPCEPTKVYGLMYFGPEELRFSRTWIGIWSVLCCASTLFTVLTYLVDMRRFSYPERPI 355
           C  PC        MYF  +EL F++++IG  S+ C  +TLFT LT+L+D+RRF YPERPI
Sbjct: 181 CAPPCPN------MYFKSDELEFAKSFIGTVSIFCLCATLFTFLTFLIDVRRFRYPERPI 234

Query: 356 IFLSGCYTAVAVAYIAGFLLEDRVVCN--DKFAEDGARTVAQGTKKEGCTILFMMLYFFS 413
           I+ S CY+ V++ Y  GFLL D   CN  D+  E G  TV  G++ + CT+LFM+LYFF+
Sbjct: 235 IYYSVCYSIVSLMYFIGFLLGDSTACNKADEKLELGD-TVVLGSQNKACTVLFMLLYFFT 293

Query: 414 MASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILALGQVDGDVL 473
           MA ++WWVIL++TWFLAAG KW  EAIE  + +FH  AW  P   T+ +LA+ +V+GD +
Sbjct: 294 MAGTVWWVILTITWFLAAGRKWSCEAIEQKAVWFHAVAWGTPGFLTVMLLAMNKVEGDNI 353

Query: 474 SGVCFVGLNNVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKL 533
           SGVCFVGL ++DA R FVL PL + +F+G S LLAG +SL  +R +++HDG   EKL+K 
Sbjct: 354 SGVCFVGLYDLDASRYFVLLPLCLCVFVGLSLLLAGIISLNHVRQVIQHDGRNQEKLKKF 413

Query: 534 MVRIGVFSVLYTVPATIVIACYFYEQAFRDQWERSWVAQSCKSYAIPCPHLQAGGGAPPH 593
           M+RIGVFS LY VP   ++ CY YEQ  R  WE +WV+  C+ Y IPCP+ QA   A   
Sbjct: 414 MIRIGVFSGLYLVPLVTLLGCYVYEQVNRITWEITWVSDHCRQYHIPCPY-QAKAKA--- 469

Query: 594 PPMSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTR 636
               P+  +FMIKYLMTLIVGI++ FW+ S KT   W  F+ R
Sbjct: 470 ---RPELALFMIKYLMTLIVGISAVFWVGSKKTCTEWAGFFKR 509


>gi|4503835 frizzled 9 [Homo sapiens]
          Length = 591

 Score =  447 bits (1149), Expect = e-125
 Identities = 244/534 (45%), Positives = 316/534 (59%), Gaps = 42/534 (7%)

Query: 116 CQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAP 175
           CQ + IP+C  I YN T MPNLLGHT+Q +A  E+ +F PLV+  C + L+FFLCS+YAP
Sbjct: 39  CQAVEIPMCRGIGYNLTRMPNLLGHTSQGEAAAELAEFAPLVQYGCHSHLRFFLCSLYAP 98

Query: 176 VCT-VLEQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFPVHGAGE-LCVGQNTS 233
           +CT  +   +P CR +CE+AR  C  +M +F F WPD+L C + P       LC+     
Sbjct: 99  MCTDQVSTPIPACRPMCEQARLRCAPIMEQFNFGWPDSLDCARLPTRNDPHALCMEA--- 155

Query: 234 DKGTPTPSLLPEFWTSNPQ--HGGGG------HRGGFPGGAGASERGKFSCPRALKVPSY 285
                     PE  T+ P   H G G           PG  G    G  +C    K    
Sbjct: 156 ----------PENATAGPAEPHKGLGMLPVAPRPARPPGDLGPGAGGSGTCENPEKFQ-- 203

Query: 286 LNYHFLGEKDCGAPCEPTKVYGLMYFGPEELRFSRTWIGIWSVLCCASTLFTVLTYLVDM 345
              +    + C   C P      +++   +  F+  W+ +WS LC  ST FTVLT+L++ 
Sbjct: 204 ---YVEKSRSCAPRCGPGVE---VFWSRRDKDFALVWMAVWSALCFFSTAFTVLTFLLEP 257

Query: 346 RRFSYPERPIIFLSGCYTAVAVAYIAGFLLEDRVVCNDKFAEDGARTVAQ-GTKKEGCTI 404
            RF YPERPIIFLS CY   ++A++   +   + V  D+  E GA  V Q G +  GCT+
Sbjct: 258 HRFQYPERPIIFLSMCYNVYSLAFLIRAVAGAQSVACDQ--EAGALYVIQEGLENTGCTL 315

Query: 405 LFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILA 464
           +F++LY+F MASS+WWV+L+LTWFLAAG KWGHEAIEA+  YFH+AAW +PA+KTI IL 
Sbjct: 316 VFLLLYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEAHGSYFHMAAWGLPALKTIVILT 375

Query: 465 LGQVDGDVLSGVCFVGLNNVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDG 524
           L +V GD L+G+C+V   +  AL GFVL PL  YL +G+SFLL GFV+LF IR IMK  G
Sbjct: 376 LRKVAGDELTGLCYVASTDAAALTGFVLVPLSGYLVLGSSFLLTGFVALFHIRKIMKTGG 435

Query: 525 TKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFRDQWERSWVAQSCKSYAIPCPHL 584
           T TEKLEKLMV+IGVFS+LYTVPAT VI CY YE+   D W      Q C + A P    
Sbjct: 436 TNTEKLEKLMVKIGVFSILYTVPATCVIVCYVYERLNMDFWRLRATEQPCAAAAGP---- 491

Query: 585 QAGGGAPPHPP--MSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTR 636
             GG      P    P   VFM+K  M+L+VGITSG W+WS KT  +W+    R
Sbjct: 492 --GGRRDCSLPGGSVPTVAVFMLKIFMSLVVGITSGVWVWSSKTFQTWQSLCYR 543


>gi|22547161 frizzled 4 [Homo sapiens]
          Length = 537

 Score =  446 bits (1147), Expect = e-125
 Identities = 238/537 (44%), Positives = 318/537 (59%), Gaps = 59/537 (10%)

Query: 106 RGISVPDHGYCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAEL 165
           RG    +   C PI I +C ++ YN T MPNL+GH  Q DA L++  F PL++  CS++L
Sbjct: 35  RGFGDEEERRCDPIRISMCQNLGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQL 94

Query: 166 KFFLCSMYAPVCTV-LEQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFPVHGAG 224
           +FFLCS+Y P+CT  +   + PC  +C   ++ CE ++ +FGF WP++L C KFP     
Sbjct: 95  QFFLCSVYVPMCTEKINIPIGPCGGMCLSVKRRCEPVLKEFGFAWPESLNCSKFPPQNDH 154

Query: 225 ELCVGQNTSDKGTPTPSLLPEFWTSNPQHGGGGHRGGFPGGAGASERGKFSCPRALKVPS 284
                +   D+  P P   P       Q G   H  G         +   +C   LK   
Sbjct: 155 NHMCMEGPGDEEVPLPHKTPI------QPGEECHSVGTNSDQYIWVKRSLNC--VLK--- 203

Query: 285 YLNYHFLGEKDCGAPCEPTKVYGLMYFGPEELRFSRTWIGIWSVLCCASTLFTVLTYLVD 344
                      CG        Y    +      F+  W+ +W+ LC  ST FTVLT+L+D
Sbjct: 204 -----------CG--------YDAGLYSRSAKEFTDIWMAVWASLCFISTAFTVLTFLID 244

Query: 345 MRRFSYPERPIIFLSGCYTAVAVAYIAGFLL-EDRVVCNDKFAEDGARTVAQGTKKEGCT 403
             RFSYPERPIIFLS CY   ++AYI    +  +R+ C+ + A +    + +G K  GC 
Sbjct: 245 SSRFSYPERPIIFLSMCYNIYSIAYIVRLTVGRERISCDFEEAAEPV-LIQEGLKNTGCA 303

Query: 404 ILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITIL 463
           I+F+++YFF MASSIWWVIL+LTWFLAAG+KWGHEAIE +S YFH+AAWA+PA+KTI IL
Sbjct: 304 IIFLLMYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTIVIL 363

Query: 464 ALGQVDGDVLSGVCFVGLNNVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHD 523
            +  VD D L+G+C+VG  N+DAL GFV+APLF YL IGT F+ AG V+LF+IR+ ++ D
Sbjct: 364 IMRLVDADELTGLCYVGNQNLDALTGFVVAPLFTYLVIGTLFIAAGLVALFKIRSNLQKD 423

Query: 524 GTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFRDQWERSWVAQSCKSYAIPCPH 583
           GTKT+KLE+LMV+IGVFSVLYTVPAT VIACYFYE +       +W              
Sbjct: 424 GTKTDKLERLMVKIGVFSVLYTVPATCVIACYFYEIS-------NWALFR---------- 466

Query: 584 LQAGGGAPPHPPMSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRLTNS 640
                    +     +  V M+K  M+L+VGITSG WIWS KTL++W+K   RL NS
Sbjct: 467 ---------YSADDSNMAVEMLKIFMSLLVGITSGMWIWSAKTLHTWQKCSNRLVNS 514


>gi|5032099 smoothened [Homo sapiens]
          Length = 787

 Score =  193 bits (490), Expect = 5e-49
 Identities = 168/629 (26%), Positives = 266/629 (42%), Gaps = 101/629 (16%)

Query: 43  RPPVDPRRLARQLLLLLWLLEAPLLLGVRAQAAGQGPGQGPGPGQQP-----PPPPQQQQ 97
           RP   P      LLLLL L +          A G GP    G  ++      PPPP    
Sbjct: 5   RPARGPELPLLGLLLLLLLGDPGRGAASSGNATGPGPRSAGGSARRSAAVTGPPPPLSHC 64

Query: 98  SGQQYNGERGISVPDHGYCQPISIPLCTDIAYNQTIMPNLLG--HTNQEDAGLEVHQFYP 155
                    G + P    C+P+   +C            LL     +QE+A  ++  +  
Sbjct: 65  ---------GRAAP----CEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSG 111

Query: 156 LVKV-QCSAELKFFLCSMYAPVCTVLEQALPPCRSLCERARQGCEALMNKFGFQWPDTLK 214
           L    +C A ++  LC++Y P C      LP  R+LC+  R  C  +  + G  WPD L+
Sbjct: 112 LRNAPRCWAVIQPLLCAVYMPKCENDRVELPS-RTLCQATRGPCAIVERERG--WPDFLR 168

Query: 215 CEKFPVHGAGELCVGQNTSDKGTPTPSLLPEFWTSNPQHGGGGHRGGFPGGAGASERGKF 274
           C                       TP   PE  T+  Q+      G              
Sbjct: 169 C-----------------------TPDRFPEGCTNEVQNIKFNSSG-------------- 191

Query: 275 SCPRALKVPSYLNYHFLGEKDCGAPCEPTKVYGLMYFGPEELRFSRTWIGIWSVLCCAST 334
            C   L         +   + CG  C+         F   E +   ++I  +  +    T
Sbjct: 192 QCEVPLVRTDNPKSWYEDVEGCGIQCQNP------LFTEAEHQDMHSYIAAFGAVTGLCT 245

Query: 335 LFTVLTYLVDMRRFS-YPERPIIFLSGCYTAVAVAYIAGFLLEDR--VVCNDKFAEDGAR 391
           LFT+ T++ D R  + YP   + +++ C+   ++ ++A F+   R  +VC      DG  
Sbjct: 246 LFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCR----ADGTM 301

Query: 392 TVAQGTKKE--GCTILFMMLYFFSMASSIWWVILSLTW---FLAAGMKWGHEAIEANSQY 446
            + + T  E   C I+F+++Y+  MA  +W+V+L+  W   F A G  +  + +   + Y
Sbjct: 302 RLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTY--QPLSGKTSY 359

Query: 447 FHLAAWAVPAIKTITILALGQVDGDVLSGVCFVGLNNVDALRGFVLAPLFVYLFIGTSFL 506
           FHL  W++P + T+ ILA+ QVDGD +SG+CFVG  N     GFVLAP+ + L +G  FL
Sbjct: 360 FHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFL 419

Query: 507 LAGFVSLFRIRTIMKHDGTKTE----KLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFR 562
           + G ++LF I++   H G  +E    K+ + M+R+G+F  L      I  +C+FY+   +
Sbjct: 420 IRGVMTLFSIKS--NHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQ 477

Query: 563 DQWERSWVAQSCKSYAIPCPHLQAGGGAPPHPPM-------SPDFTVFMIKYLMTLIVGI 615
            +WERS+     + Y +   ++    G P   P+        P   V  I        GI
Sbjct: 478 AEWERSF-----RDYVLCQANVTI--GLPTKQPIPDCEIKNRPSLLVEKINLFAMFGTGI 530

Query: 616 TSGFWIWSGKTLNSWRKFYTRLTNSKQGE 644
               W+W+  TL  WR+ + RLT     E
Sbjct: 531 AMSTWVWTKATLLIWRRTWCRLTGQSDDE 559


>gi|38455388 frizzled-related protein [Homo sapiens]
          Length = 325

 Score =  124 bits (310), Expect = 4e-28
 Identities = 54/115 (46%), Positives = 78/115 (67%), Gaps = 3/115 (2%)

Query: 116 CQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAP 175
           C+P+ IPLC  + +N T MPN L H+ Q +A L + QF  L+   CS +L FFLC+MYAP
Sbjct: 35  CEPVRIPLCKSLPWNMTKMPNHLHHSTQANAILAIEQFEGLLGTHCSPDLLFFLCAMYAP 94

Query: 176 VCTV--LEQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFPVHGAGELCV 228
           +CT+    + + PC+S+CERARQGCE ++ K+   WP+ L CE+ PV+  G +C+
Sbjct: 95  ICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPENLACEELPVYDRG-VCI 148


>gi|170784838 secreted frizzled-related  protein 4 [Homo sapiens]
          Length = 346

 Score =  120 bits (301), Expect = 4e-27
 Identities = 53/115 (46%), Positives = 78/115 (67%), Gaps = 3/115 (2%)

Query: 116 CQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAP 175
           C+ + IP+C  + +N T MPN L H+ QE+A L + Q+  LV V CSA L+FFLC+MYAP
Sbjct: 24  CEAVRIPMCRHMPWNITRMPNHLHHSTQENAILAIEQYEELVDVNCSAVLRFFLCAMYAP 83

Query: 176 VCTV--LEQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFPVHGAGELCV 228
           +CT+  L   + PC+S+C+RAR  CE LM  +   WP++L C++ PV+  G +C+
Sbjct: 84  ICTLEFLHDPIKPCKSVCQRARDDCEPLMKMYNHSWPESLACDELPVYDRG-VCI 137


>gi|48475052 secreted frizzled-related protein 2 precursor [Homo
           sapiens]
          Length = 295

 Score =  104 bits (260), Expect = 2e-22
 Identities = 54/142 (38%), Positives = 79/142 (55%), Gaps = 9/142 (6%)

Query: 111 PDHGY----CQPI--SIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAE 164
           PD  Y    C+PI  ++ LC  I Y    +PNLLGH   ++   +   + PLV  QC  +
Sbjct: 31  PDFSYKRSNCKPIPANLQLCHGIEYQNMRLPNLLGHETMKEVLEQAGAWIPLVMKQCHPD 90

Query: 165 LKFFLCSMYAPVC-TVLEQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFPVHGA 223
            K FLCS++APVC   L++ + PC SLC + +  C  +M+ FGF WPD L+C++FP    
Sbjct: 91  TKKFLCSLFAPVCLDDLDETIQPCHSLCVQVKDRCAPVMSAFGFPWPDMLECDRFPQD-- 148

Query: 224 GELCVGQNTSDKGTPTPSLLPE 245
            +LC+   +SD   P     P+
Sbjct: 149 NDLCIPLASSDHLLPATEEAPK 170


>gi|188528609 secreted frizzled-related protein 5 [Homo sapiens]
          Length = 317

 Score =  103 bits (258), Expect = 4e-22
 Identities = 48/123 (39%), Positives = 71/123 (57%), Gaps = 4/123 (3%)

Query: 106 RGISVPDHGYCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAEL 165
           R  S P      P  +PLC  + Y +  +PNLL H +  +   +   + PL+  +C ++ 
Sbjct: 45  RSYSKPPQCLDIPADLPLCHTVGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDT 104

Query: 166 KFFLCSMYAPVCTVLEQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFPVHGAGE 225
           + FLCS++APVC  L++ + PCRSLCE  R GC  LM  +GF WP+ L C KFP+    +
Sbjct: 105 QVFLCSLFAPVC--LDRPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPLD--ND 160

Query: 226 LCV 228
           LC+
Sbjct: 161 LCI 163


>gi|56117838 secreted frizzled-related protein 1 [Homo sapiens]
          Length = 314

 Score =  103 bits (257), Expect = 5e-22
 Identities = 48/127 (37%), Positives = 71/127 (55%), Gaps = 5/127 (3%)

Query: 102 YNGERGISVPDHGYCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQC 161
           Y   R  + P      P  + LC ++ Y + ++PNLL H    +   +   + PL+   C
Sbjct: 46  YQSGRFYTKPPQCVDIPADLRLCHNVGYKKMVLPNLLEHETMAEVKQQASSWVPLLNKNC 105

Query: 162 SAELKFFLCSMYAPVCTVLEQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFPVH 221
            A  + FLCS++APVC  L++ + PCR LCE  R  CE +M  FGF WP+ LKC+KFP  
Sbjct: 106 HAGTQVFLCSLFAPVC--LDRPIYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKFP-- 161

Query: 222 GAGELCV 228
             G++C+
Sbjct: 162 -EGDVCI 167


>gi|29244926 corin [Homo sapiens]
          Length = 1042

 Score = 95.5 bits (236), Expect = 1e-19
 Identities = 42/107 (39%), Positives = 64/107 (59%), Gaps = 3/107 (2%)

Query: 116 CQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGL--EVHQFYPLVKVQCSAELKFFLCSMY 173
           C+PI++ LC ++ YN T  PN  GH  Q++A +  E   F  LV+  C   L FF C++ 
Sbjct: 455 CEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFPALVQTNCYKYLMFFSCTIL 514

Query: 174 APVCTV-LEQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFP 219
            P C V   + +PPCR+LCE +++ CE+++   G QWP+   C +FP
Sbjct: 515 VPKCDVNTGEHIPPCRALCEHSKERCESVLGIVGLQWPEDTDCSQFP 561



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 33/106 (31%), Positives = 52/106 (49%), Gaps = 4/106 (3%)

Query: 116 CQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAP 175
           C  I+   C  + Y+ T+ P L    N E     +  F  L ++ C   +  F C++  P
Sbjct: 139 CMNITHSQCQMLPYHATLTPLLSVVRNMEMEKF-LKFFTYLHRLSCYQHIMLFGCTLAFP 197

Query: 176 VCTVL---EQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKF 218
            C +       L PCRS CE A++GCE+++    + WPD L+C +F
Sbjct: 198 ECIIDGDDSHGLLPCRSFCEAAKEGCESVLGMVNYSWPDFLRCSQF 243


>gi|13899255 membrane frizzled-related protein [Homo sapiens]
          Length = 579

 Score = 76.3 bits (186), Expect = 8e-14
 Identities = 35/113 (30%), Positives = 55/113 (48%), Gaps = 3/113 (2%)

Query: 116 CQPISIPLCTDIAYNQTIMPNL-LGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYA 174
           C+P+ + +C  ++YN T  PN+ +G   QE+    +  +  L  + C    +  LC +  
Sbjct: 466 CEPVQVEMCLGLSYNTTAFPNIWVGMITQEEVVEVLSGYKSLTSLPCYQHFRRLLCGLLV 525

Query: 175 PVCTVLEQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFPVHGAGELC 227
           P CT L   LPPCRS+C+ A   C++ +   G  WP    C + P     E C
Sbjct: 526 PRCTPLGSVLPPCRSVCQEAEHQCQSGLALLGTPWP--FNCNRLPEAADLEAC 576


>gi|62388877 carboxypeptidase Z isoform 1 [Homo sapiens]
          Length = 652

 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 35/112 (31%), Positives = 55/112 (49%), Gaps = 6/112 (5%)

Query: 112 DHGYCQPISIPLCTDIAYNQTIMPNLLGHTNQE--DAGLE---VHQFYPLVKVQCSAELK 166
           D   C  + +  C+D AYN T  PNLL H + E  +A  E   +   + L++ QC+ +L+
Sbjct: 39  DSATCVDLQLRTCSDAAYNHTTFPNLLQHRSWEVVEASSEYILLSVLHQLLEGQCNPDLR 98

Query: 167 FFLCSMYAPVCTVLEQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKF 218
              C++ AP C        PCR +CE  R+ C+   +     WP  L C ++
Sbjct: 99  LLGCAVLAPRCEG-GWVRRPCRHICEGLREVCQPAFDAIDMAWPYFLDCHRY 149


>gi|62388875 carboxypeptidase Z isoform 2 precursor [Homo sapiens]
          Length = 641

 Score = 63.2 bits (152), Expect = 7e-10
 Identities = 34/108 (31%), Positives = 54/108 (50%), Gaps = 6/108 (5%)

Query: 116 CQPISIPLCTDIAYNQTIMPNLLGHTNQE--DAGLE---VHQFYPLVKVQCSAELKFFLC 170
           C  + +  C+D AYN T  PNLL H + E  +A  E   +   + L++ QC+ +L+   C
Sbjct: 32  CVDLQLRTCSDAAYNHTTFPNLLQHRSWEVVEASSEYILLSVLHQLLEGQCNPDLRLLGC 91

Query: 171 SMYAPVCTVLEQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKF 218
           ++ AP C        PCR +CE  R+ C+   +     WP  L C ++
Sbjct: 92  AVLAPRCEG-GWVRRPCRHICEGLREVCQPAFDAIDMAWPYFLDCHRY 138


>gi|206597445 alpha 1 type XVIII collagen isoform 3 precursor [Homo
           sapiens]
          Length = 1751

 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 26/88 (29%), Positives = 41/88 (46%), Gaps = 3/88 (3%)

Query: 114 GYCQPI--SIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCS 171
           G C P+  S+P+C  +  ++  +PN L H + E        +  L++  C   L +F C 
Sbjct: 332 GRCLPLPPSLPVCGHLGISRFWLPNHLHHESGEQVRAGARAWGGLLQTHCHPFLAWFFCL 391

Query: 172 MYAPVC-TVLEQALPPCRSLCERARQGC 198
           +  P C +V   A PPC   CE  +  C
Sbjct: 392 LLVPPCGSVPPPAPPPCCQFCEALQDAC 419


>gi|239751080 PREDICTED: hypothetical protein XP_002347700 [Homo
           sapiens]
          Length = 330

 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 38/113 (33%), Positives = 48/113 (42%), Gaps = 22/113 (19%)

Query: 3   EEEAPKKSRAAGGGASWELCAGALSARLAEEGS----------GDAGGRRRPPVD----P 48
           E   P+  R+A   AS   CAG L   L  +G+          G  G RRRP       P
Sbjct: 162 ERTKPRSGRSADTEASAP-CAGLLVRVLTFDGNSAMAAPLASRGRYGRRRRPSSGGCRLP 220

Query: 49  RRLARQLLLLLWL--LEAPLLLGVRAQAAGQGPGQGPGPGQQP-----PPPPQ 94
           RR + +L + +WL  L+    LG      G+ PG  P  G  P     PPPPQ
Sbjct: 221 RRFSPRLRIPVWLQALQEASGLGAWGARCGRDPGSAPAAGAAPLTLCSPPPPQ 273


>gi|239745567 PREDICTED: hypothetical protein XP_002344149 [Homo
           sapiens]
          Length = 330

 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 38/113 (33%), Positives = 48/113 (42%), Gaps = 22/113 (19%)

Query: 3   EEEAPKKSRAAGGGASWELCAGALSARLAEEGS----------GDAGGRRRPPVD----P 48
           E   P+  R+A   AS   CAG L   L  +G+          G  G RRRP       P
Sbjct: 162 ERTKPRSGRSADTEASAP-CAGLLVRVLTFDGNSAMAAPLASRGRYGRRRRPSSGGCRLP 220

Query: 49  RRLARQLLLLLWL--LEAPLLLGVRAQAAGQGPGQGPGPGQQP-----PPPPQ 94
           RR + +L + +WL  L+    LG      G+ PG  P  G  P     PPPPQ
Sbjct: 221 RRFSPRLRIPVWLQALQEASGLGAWGARCGRDPGSAPAAGAAPLTLCSPPPPQ 273


>gi|122937267 lemur tyrosine kinase 3 [Homo sapiens]
          Length = 1489

 Score = 37.4 bits (85), Expect = 0.043
 Identities = 37/106 (34%), Positives = 42/106 (39%), Gaps = 22/106 (20%)

Query: 10  SRAAGGGASWE------LCA--GALSARLAEEGSGDAG-------GRRRPPVDPRRLARQ 54
           S + GGG S        LC+  GA S    E G   AG       G   PP D   L  +
Sbjct: 683 SSSLGGGPSRRGPLPCPLCSREGACSCLPLERGDAVAGWGGHPALGCPHPPEDDSSLRAE 742

Query: 55  LLLLLWLLEAP-------LLLGVRAQAAGQGPGQGPGPGQQPPPPP 93
              L  L  AP        L  +   AA Q PG+GP P   PPPPP
Sbjct: 743 RGSLADLPMAPPASAPPEFLDPLMGAAAPQYPGRGPPPAPPPPPPP 788


>gi|59806361 hypothetical protein LOC387104 [Homo sapiens]
          Length = 947

 Score = 36.6 bits (83), Expect = 0.074
 Identities = 39/115 (33%), Positives = 49/115 (42%), Gaps = 14/115 (12%)

Query: 2   AEEEAPKKSRAAGGGASWELCAGALSARLAEEGSGDAGGRRRPPVDPRRLARQLLLLLWL 61
           AE+  P   + A  GA   + AGA +A  A   +   GGRR  P  P    R+L  +   
Sbjct: 102 AEKATPLAPKGAAPGAVQPV-AGAEAAPAATLAA--LGGRRPGP--PEEPPRELESVPSK 156

Query: 62  LEAPLLLGVRAQAAGQGPGQGPGPGQ------QPPPPPQQQQSG---QQYNGERG 107
           L  P  LG      G+G G G G G+      QPPPP   +  G   QQ  G  G
Sbjct: 157 LGEPPPLGEGGGGGGEGGGAGGGSGEREGGAPQPPPPRGWRGKGVRAQQRGGSGG 211


>gi|66882532 farnesyltransferase, CAAX box, alpha isoform c [Homo
           sapiens]
          Length = 312

 Score = 36.6 bits (83), Expect = 0.074
 Identities = 19/42 (45%), Positives = 22/42 (52%)

Query: 69  GVRAQAAGQGPGQGPGPGQQPPPPPQQQQSGQQYNGERGISV 110
           GV   A G  PGQ   P  QP PPP QQQ  ++   E G +V
Sbjct: 6   GVGEAAQGGEPGQPAQPPPQPHPPPPQQQHKEEMAAEAGEAV 47


>gi|4503771 farnesyltransferase, CAAX box, alpha isoform a [Homo
           sapiens]
          Length = 379

 Score = 36.6 bits (83), Expect = 0.074
 Identities = 19/42 (45%), Positives = 22/42 (52%)

Query: 69  GVRAQAAGQGPGQGPGPGQQPPPPPQQQQSGQQYNGERGISV 110
           GV   A G  PGQ   P  QP PPP QQQ  ++   E G +V
Sbjct: 6   GVGEAAQGGEPGQPAQPPPQPHPPPPQQQHKEEMAAEAGEAV 47


>gi|208022661 hypothetical protein LOC57701 [Homo sapiens]
          Length = 1334

 Score = 36.6 bits (83), Expect = 0.074
 Identities = 33/91 (36%), Positives = 40/91 (43%), Gaps = 5/91 (5%)

Query: 13  AGGGASWELCAGALSARLAEEGSGDAGGRRRPPVDPRRLARQLLLLLWLLE--APLLLGV 70
           A G +S   CA   S+  + + +GD      P      LAR+ L L  LLE     L   
Sbjct: 283 AQGTSSGPNCAPGSSSSSSSDEAGDPNEAPSPDTLLGALARRQLNLGQLLEDTESYLQAF 342

Query: 71  RAQAAGQGPGQGPGPGQQPPP---PPQQQQS 98
            A AAG   G  PGPGQ   P   PPQ  +S
Sbjct: 343 LAGAAGPLNGDHPGPGQSSSPDQAPPQLSKS 373


>gi|110832843 TBP-associated factor 4 [Homo sapiens]
          Length = 1085

 Score = 35.4 bits (80), Expect = 0.16
 Identities = 20/56 (35%), Positives = 25/56 (44%), Gaps = 3/56 (5%)

Query: 69  GVRAQAAGQGPGQGPGPGQQPPPPPQQQQ---SGQQYNGERGISVPDHGYCQPISI 121
           G  A AA  GPG GPGPG  P P P +     + Q  NG   +    H     +S+
Sbjct: 162 GPAALAARAGPGPGPGPGPGPGPGPGKPAGPGAAQTLNGSAALLNSHHAAAPAVSL 217


>gi|192807323 SWI/SNF-related matrix-associated actin-dependent
           regulator of chromatin a4 isoform A [Homo sapiens]
          Length = 1679

 Score = 35.0 bits (79), Expect = 0.22
 Identities = 20/60 (33%), Positives = 25/60 (41%), Gaps = 6/60 (10%)

Query: 63  EAPLLLGVRAQAAGQGPGQGPGPGQQPPPPPQQQQSGQQYNGERGISVPDHGYCQPISIP 122
           + P L      A G GPG GPGPG  P P P        Y+   G+  P+     P  +P
Sbjct: 216 QMPTLPPPSVSATGPGPGPGPGPGPGPGPAP------PNYSRPHGMGGPNMPPPGPSGVP 269


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.139    0.455 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,804,230
Number of Sequences: 37866
Number of extensions: 1638890
Number of successful extensions: 12848
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 90
Number of HSP's successfully gapped in prelim test: 123
Number of HSP's that attempted gapping in prelim test: 11696
Number of HSP's gapped (non-prelim): 1004
length of query: 647
length of database: 18,247,518
effective HSP length: 109
effective length of query: 538
effective length of database: 14,120,124
effective search space: 7596626712
effective search space used: 7596626712
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.