Guide to the Human Genome
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Search of human proteins with 4503559

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4503559 epithelial membrane protein 1 [Homo sapiens]
         (157 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4503559 epithelial membrane protein 1 [Homo sapiens]               319   7e-88
gi|4505907 peripheral myelin protein 22 [Homo sapiens]                127   3e-30
gi|24430165 peripheral myelin protein 22 [Homo sapiens]               127   3e-30
gi|24430163 peripheral myelin protein 22 [Homo sapiens]               127   3e-30
gi|4503561 epithelial membrane protein 2 [Homo sapiens]               121   3e-28
gi|4503563 epithelial membrane protein 3 [Homo sapiens]                94   6e-20
gi|239747698 PREDICTED: similar to hCG1784039 [Homo sapiens]           69   2e-12
gi|239916002 lens intrinsic membrane protein 2, 19kDa isoform 2 ...    56   1e-08
gi|50345279 claudin 18 isoform 2 [Homo sapiens]                        49   1e-06
gi|7705961 claudin 18 isoform 1 [Homo sapiens]                         47   9e-06
gi|21361300 lens intrinsic membrane protein 2, 19kDa isoform 1 [...    44   7e-05
gi|22748765 claudin domain containing 2 [Homo sapiens]                 43   1e-04
gi|169163665 PREDICTED: similar to hCG1784039 [Homo sapiens]           40   0.001
gi|169163222 PREDICTED: hypothetical protein LOC391359 [Homo sap...    40   0.001
gi|5921465 claudin 10 isoform b [Homo sapiens]                         36   0.015
gi|122937323 transmembrane protein 202 [Homo sapiens]                  36   0.015
gi|48255959 plasma membrane calcium ATPase 4 isoform 4a [Homo sa...    35   0.020
gi|48255957 plasma membrane calcium ATPase 4 isoform 4b [Homo sa...    35   0.020
gi|24586686 voltage-dependent calcium channel gamma-8 subunit [H...    35   0.026
gi|183979973 claudin 19 isoform a [Homo sapiens]                       33   0.076
gi|124107616 claudin 23 [Homo sapiens]                                 33   0.076
gi|10938016 claudin 11 [Homo sapiens]                                  33   0.076
gi|183979975 claudin 19 isoform b [Homo sapiens]                       33   0.076
gi|5174405 voltage-dependent calcium channel gamma-2 subunit [Ho...    33   0.100
gi|5729756 voltage-dependent calcium channel gamma-3 subunit [Ho...    33   0.100
gi|153792768 claudin 6 [Homo sapiens]                                  32   0.22 
gi|33598916 claudin 10 isoform a [Homo sapiens]                        32   0.22 
gi|231569235 claudin 10 isoform a_i1 [Homo sapiens]                    32   0.29 
gi|239756473 PREDICTED: transmembrane protein 114 [Homo sapiens]       31   0.38 
gi|239752599 PREDICTED: transmembrane protein 114, partial [Homo...    31   0.38 

>gi|4503559 epithelial membrane protein 1 [Homo sapiens]
          Length = 157

 Score =  319 bits (817), Expect = 7e-88
 Identities = 157/157 (100%), Positives = 157/157 (100%)

Query: 1   MLVLLAGIFVVHIATVIMLFVSTIANVWLVSNTVDASVGLWKNCTNISCSDSLSYASEDA 60
           MLVLLAGIFVVHIATVIMLFVSTIANVWLVSNTVDASVGLWKNCTNISCSDSLSYASEDA
Sbjct: 1   MLVLLAGIFVVHIATVIMLFVSTIANVWLVSNTVDASVGLWKNCTNISCSDSLSYASEDA 60

Query: 61  LKTVQAFMILSIIFCVIALLVFVFQLFTMEKGNRFFLSGATTLVCWLCILVGVSIYTSHY 120
           LKTVQAFMILSIIFCVIALLVFVFQLFTMEKGNRFFLSGATTLVCWLCILVGVSIYTSHY
Sbjct: 61  LKTVQAFMILSIIFCVIALLVFVFQLFTMEKGNRFFLSGATTLVCWLCILVGVSIYTSHY 120

Query: 121 ANRDGTQYHHGYSYILGWICFCFSFIIGVLYLVLRKK 157
           ANRDGTQYHHGYSYILGWICFCFSFIIGVLYLVLRKK
Sbjct: 121 ANRDGTQYHHGYSYILGWICFCFSFIIGVLYLVLRKK 157


>gi|4505907 peripheral myelin protein 22 [Homo sapiens]
          Length = 160

 Score =  127 bits (320), Expect = 3e-30
 Identities = 64/161 (39%), Positives = 104/161 (64%), Gaps = 6/161 (3%)

Query: 1   MLVLLAGIFVVHIATVIMLFVSTIANVWLVSNTVDASVGLWKNCTNISCSD---SLSYAS 57
           ML+LL  I V+H+A +++LFVSTI + W+V N    +  LW+NC+  S  +     S + 
Sbjct: 1   MLLLLLSIIVLHVAVLVLLFVSTIVSQWIVGN--GHATDLWQNCSTSSSGNVHHCFSSSP 58

Query: 58  EDALKTVQAFMILSIIFCVIALLVFVFQLFTMEKGNRFFLSGATTLVCWLCILVGVSIYT 117
            + L++VQA MILSIIF +++L +F  QLFT+ KG RF+++G   ++  LC++   +IYT
Sbjct: 59  NEWLQSVQATMILSIIFSILSLFLFFCQLFTLTKGGRFYITGIFQILAGLCVMSAAAIYT 118

Query: 118 -SHYANRDGTQYHHGYSYILGWICFCFSFIIGVLYLVLRKK 157
             H      + Y +G++YIL W+ F  + + GV+Y++LRK+
Sbjct: 119 VRHPEWHLNSDYSYGFAYILAWVAFPLALLSGVIYVILRKR 159


>gi|24430165 peripheral myelin protein 22 [Homo sapiens]
          Length = 160

 Score =  127 bits (320), Expect = 3e-30
 Identities = 64/161 (39%), Positives = 104/161 (64%), Gaps = 6/161 (3%)

Query: 1   MLVLLAGIFVVHIATVIMLFVSTIANVWLVSNTVDASVGLWKNCTNISCSD---SLSYAS 57
           ML+LL  I V+H+A +++LFVSTI + W+V N    +  LW+NC+  S  +     S + 
Sbjct: 1   MLLLLLSIIVLHVAVLVLLFVSTIVSQWIVGN--GHATDLWQNCSTSSSGNVHHCFSSSP 58

Query: 58  EDALKTVQAFMILSIIFCVIALLVFVFQLFTMEKGNRFFLSGATTLVCWLCILVGVSIYT 117
            + L++VQA MILSIIF +++L +F  QLFT+ KG RF+++G   ++  LC++   +IYT
Sbjct: 59  NEWLQSVQATMILSIIFSILSLFLFFCQLFTLTKGGRFYITGIFQILAGLCVMSAAAIYT 118

Query: 118 -SHYANRDGTQYHHGYSYILGWICFCFSFIIGVLYLVLRKK 157
             H      + Y +G++YIL W+ F  + + GV+Y++LRK+
Sbjct: 119 VRHPEWHLNSDYSYGFAYILAWVAFPLALLSGVIYVILRKR 159


>gi|24430163 peripheral myelin protein 22 [Homo sapiens]
          Length = 160

 Score =  127 bits (320), Expect = 3e-30
 Identities = 64/161 (39%), Positives = 104/161 (64%), Gaps = 6/161 (3%)

Query: 1   MLVLLAGIFVVHIATVIMLFVSTIANVWLVSNTVDASVGLWKNCTNISCSD---SLSYAS 57
           ML+LL  I V+H+A +++LFVSTI + W+V N    +  LW+NC+  S  +     S + 
Sbjct: 1   MLLLLLSIIVLHVAVLVLLFVSTIVSQWIVGN--GHATDLWQNCSTSSSGNVHHCFSSSP 58

Query: 58  EDALKTVQAFMILSIIFCVIALLVFVFQLFTMEKGNRFFLSGATTLVCWLCILVGVSIYT 117
            + L++VQA MILSIIF +++L +F  QLFT+ KG RF+++G   ++  LC++   +IYT
Sbjct: 59  NEWLQSVQATMILSIIFSILSLFLFFCQLFTLTKGGRFYITGIFQILAGLCVMSAAAIYT 118

Query: 118 -SHYANRDGTQYHHGYSYILGWICFCFSFIIGVLYLVLRKK 157
             H      + Y +G++YIL W+ F  + + GV+Y++LRK+
Sbjct: 119 VRHPEWHLNSDYSYGFAYILAWVAFPLALLSGVIYVILRKR 159


>gi|4503561 epithelial membrane protein 2 [Homo sapiens]
          Length = 167

 Score =  121 bits (303), Expect = 3e-28
 Identities = 68/171 (39%), Positives = 98/171 (57%), Gaps = 19/171 (11%)

Query: 1   MLVLLAGIFVVHIATVIMLFVSTIANVWLVSNTVDASVGLWKNCTNISCSDSL--SYASE 58
           MLVLLA I   HI +  +LF++T+ N W V +   A V  W+ CTN +    +  S+   
Sbjct: 1   MLVLLAFIIAFHITSAALLFIATVDNAWWVGDEFFADV--WRICTNNTNCTVINDSFQEY 58

Query: 59  DALKTVQAFMILSIIFCVIALLVFVFQLFTMEKGNRFFLSGATTLVCWLCILVGVSIYTS 118
             L+ VQA MILS I C IA  +FV QLF +++G RF L+    L+  LC+++  SIYT 
Sbjct: 59  STLQAVQATMILSTILCCIAFFIFVLQLFRLKQGERFVLTSIIQLMSCLCVMIAASIYTD 118

Query: 119 ------------HYANRDGTQYHHGYSYILGWICFCFSFIIGVLYLVLRKK 157
                       +   R+G+   +GYSYIL W+ F  +FI G++YL+LRK+
Sbjct: 119 RREDIHDKNAKFYPVTREGS---YGYSYILAWVAFACTFISGMMYLILRKR 166


>gi|4503563 epithelial membrane protein 3 [Homo sapiens]
          Length = 163

 Score = 93.6 bits (231), Expect = 6e-20
 Identities = 55/166 (33%), Positives = 91/166 (54%), Gaps = 13/166 (7%)

Query: 1   MLVLLAGIFVVHIATVIMLFVSTIANVWLVSNTVDASVGLWKNCT--NISCSDSLSYASE 58
           M +LL  +  +HI  +I+LFV+T+   W      + S+ LW +CT  N + + + S  SE
Sbjct: 1   MSLLLLVVSALHILILILLFVATLDKSWWTLPGKE-SLNLWYDCTWNNDTKTWACSNVSE 59

Query: 59  DA-LKTVQAFMILSIIFCVIALLVFVFQLFTMEKGNRFFLSGATTLVCWLCILVGVSIYT 117
           +  LK VQ  M+LS+I C ++ ++F+FQL+TM +G  F+ +G   L   + +  G  IY 
Sbjct: 60  NGWLKAVQVLMVLSLILCCLSFILFMFQLYTMRRGGLFYATGLCQLCTSVAVFTGALIYA 119

Query: 118 SHYAN------RDGTQYHHGYSYILGWICFCFSFIIGVLYLVLRKK 157
            H         R G+    GY + L W+ F  + + G++Y+ LRK+
Sbjct: 120 IHAEEILEKHPRGGS---FGYCFALAWVAFPLALVSGIIYIHLRKR 162


>gi|239747698 PREDICTED: similar to hCG1784039 [Homo sapiens]
          Length = 161

 Score = 68.6 bits (166), Expect = 2e-12
 Identities = 51/165 (30%), Positives = 81/165 (49%), Gaps = 21/165 (12%)

Query: 1   MLVLLAGIFVVHIATVIMLFVSTIANVWLVSNTVDASVGLWKNCT-NISCS---DSLSYA 56
           MLVLL      HI +  +LF++TI N W V N   A V  W+ CT N  C+   DS    
Sbjct: 1   MLVLLTFTVAFHITSAALLFIATIDNAWWVGNEFFADV--WRICTKNTKCTVINDSFKEY 58

Query: 57  SEDALKTVQAFMILSIIFCVIALLVFVFQLFTMEKGNRFFLSGATTLVCWLCILVGVSIY 116
           S    + +    ++  ++   A  +   ++ T        L  AT  + +LC+++  SIY
Sbjct: 59  SMGRARWLTP--VIPALWEAEACGLXGQEIETSLANIMKLLHHAT--MSYLCLMIAASIY 114

Query: 117 TS--------HYANRDGTQYHHGYSYILGWICFCFSFIIGVLYLV 153
           T         +Y  ++G+   +GYSYIL W+ F F+FI  ++YL+
Sbjct: 115 TDRRDETTDFYYLTKEGS---YGYSYILAWVAFAFTFISSMMYLI 156


>gi|239916002 lens intrinsic membrane protein 2, 19kDa isoform 2
           [Homo sapiens]
          Length = 173

 Score = 56.2 bits (134), Expect = 1e-08
 Identities = 43/158 (27%), Positives = 74/158 (46%), Gaps = 19/158 (12%)

Query: 7   GIFVVHIATVIMLFVSTIANVWLVSNTVD--ASVGLWKNCTNISC---SDSLSYASEDAL 61
           G+F   + T I+L V+   + W+        A  GLW+ C    C   +DS++Y +    
Sbjct: 8   GLFCAWVGT-ILLVVAMATDHWMQYRLSGSFAHQGLWRYCLGNKCYLQTDSIAYWN---- 62

Query: 62  KTVQAFMILSIIFCVIALLVFVFQLF----TMEKGNRFFLSGATTLVCWLCILVGVSIYT 117
              +AFMILS + C I+ ++     F    T  + +R F +G       L +++ ++IYT
Sbjct: 63  -ATRAFMILSAL-CAISGIIMGIMAFAHQPTFSRISRPFSAGIMFFSSTLFVVLALAIYT 120

Query: 118 S---HYANRDGTQYHHGYSYILGWICFCFSFIIGVLYL 152
                +  R    +   +SYILGW+    +F  G+ Y+
Sbjct: 121 GVTVSFLGRRFGDWRFSWSYILGWVAVLMTFFAGIFYM 158


>gi|50345279 claudin 18 isoform 2 [Homo sapiens]
          Length = 261

 Score = 49.3 bits (116), Expect = 1e-06
 Identities = 48/184 (26%), Positives = 75/184 (40%), Gaps = 39/184 (21%)

Query: 9   FVVHIATVIMLFVSTIANVW----LVSNTVDASV---GLWKNCTNIS-----CSDSLSYA 56
           FVV +  +  +  +T  + W    L +N V A     GLW++C   S     C    +  
Sbjct: 11  FVVSLIGIAGIIAATCMDQWSTQDLYNNPVTAVFNYQGLWRSCVRESSGFTECRGYFTLL 70

Query: 57  SEDA-LKTVQAFMILSIIFCVIALLVFVFQLFTME--------KGNRFFLSGATTLVCWL 107
              A L+ V+A MI+ I+   I LLV +F L  +         K N    SG   +V  L
Sbjct: 71  GLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLTSGIMFIVSGL 130

Query: 108 CILVGVSIY------------TSHYANRDG------TQYHHGYSYILGWICFCFSFIIGV 149
           C + GVS++             + Y    G      T+Y  G +  +GW+    + I GV
Sbjct: 131 CAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWVAGGLTLIGGV 190

Query: 150 LYLV 153
           +  +
Sbjct: 191 MMCI 194


>gi|7705961 claudin 18 isoform 1 [Homo sapiens]
          Length = 261

 Score = 46.6 bits (109), Expect = 9e-06
 Identities = 45/184 (24%), Positives = 73/184 (39%), Gaps = 39/184 (21%)

Query: 9   FVVHIATVIMLFVSTIANVWLVSNTVDASV-------GLWKNCTNIS-----CSDSLSYA 56
           F++ I  +     +T  ++W   +  D  V       GLW++C   S     C    +  
Sbjct: 11  FLLSILGLAGCIAATGMDMWSTQDLYDNPVTSVFQYEGLWRSCVRQSSGFTECRPYFTIL 70

Query: 57  SEDA-LKTVQAFMILSIIFCVIALLVFVFQLFTME--------KGNRFFLSGATTLVCWL 107
              A L+ V+A MI+ I+   I LLV +F L  +         K N    SG   +V  L
Sbjct: 71  GLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLTSGIMFIVSGL 130

Query: 108 CILVGVSIY------------TSHYANRDG------TQYHHGYSYILGWICFCFSFIIGV 149
           C + GVS++             + Y    G      T+Y  G +  +GW+    + I GV
Sbjct: 131 CAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWVAGGLTLIGGV 190

Query: 150 LYLV 153
           +  +
Sbjct: 191 MMCI 194


>gi|21361300 lens intrinsic membrane protein 2, 19kDa isoform 1
           [Homo sapiens]
          Length = 215

 Score = 43.5 bits (101), Expect = 7e-05
 Identities = 28/104 (26%), Positives = 50/104 (48%), Gaps = 8/104 (7%)

Query: 56  ASEDALKTVQAFMILSIIFCVIALLVFVFQLF----TMEKGNRFFLSGATTLVCWLCILV 111
           A++      +AFMILS + C I+ ++     F    T  + +R F +G       L +++
Sbjct: 98  ATQAYWNATRAFMILSAL-CAISGIIMGIMAFAHQPTFSRISRPFSAGIMFFSSTLFVVL 156

Query: 112 GVSIYTS---HYANRDGTQYHHGYSYILGWICFCFSFIIGVLYL 152
            ++IYT     +  R    +   +SYILGW+    +F  G+ Y+
Sbjct: 157 ALAIYTGVTVSFLGRRFGDWRFSWSYILGWVAVLMTFFAGIFYM 200


>gi|22748765 claudin domain containing 2 [Homo sapiens]
          Length = 167

 Score = 42.7 bits (99), Expect = 1e-04
 Identities = 36/147 (24%), Positives = 67/147 (45%), Gaps = 8/147 (5%)

Query: 7   GIFVVHIATVIMLFVSTIANVWLVSNTVDASVGLWKNCTNISCSDSLSYASEDALKTVQA 66
           GI +  +A V+M+ +ST  N W  +   +   GLW+ C +  CS   S   +  L    A
Sbjct: 11  GILLSLVANVLMV-LSTATNYW--TRQQEGHSGLWQECNHGICS---SIPCQTTLAVTVA 64

Query: 67  FMILSIIFCVIALLVFVFQLFTMEKGNRFFLSGATTLVCWLCILVGVSIYTSHYANRDGT 126
            M+L++   V+ +++ +       +  R   + A   +  L +L  +  YT   A ++  
Sbjct: 65  CMVLAVGVGVVGMVMGLRIRCDEGESLRGQTTSAFLFLGGLLLLTALIGYTVKNAWKNNV 124

Query: 127 QYHHGYSYILGWICFCFSFIIGVLYLV 153
            +   +SY  GW+   FS + G  +L+
Sbjct: 125 FF--SWSYFSGWLALPFSILAGFCFLL 149


>gi|169163665 PREDICTED: similar to hCG1784039 [Homo sapiens]
          Length = 93

 Score = 39.7 bits (91), Expect = 0.001
 Identities = 15/35 (42%), Positives = 25/35 (71%), Gaps = 3/35 (8%)

Query: 119 HYANRDGTQYHHGYSYILGWICFCFSFIIGVLYLV 153
           +Y  ++G+   +GYSYIL W+ F F+FI  ++YL+
Sbjct: 57  YYLTKEGS---YGYSYILAWVAFAFTFISSMMYLI 88



 Score = 38.9 bits (89), Expect = 0.002
 Identities = 20/45 (44%), Positives = 25/45 (55%), Gaps = 2/45 (4%)

Query: 1  MLVLLAGIFVVHIATVIMLFVSTIANVWLVSNTVDASVGLWKNCT 45
          MLVLL      HI +  +LF++TI N W V N   A V  W+ CT
Sbjct: 1  MLVLLTFTVAFHITSAALLFIATIDNAWWVGNEFFADV--WRICT 43


>gi|169163222 PREDICTED: hypothetical protein LOC391359 [Homo
           sapiens]
          Length = 93

 Score = 39.7 bits (91), Expect = 0.001
 Identities = 15/35 (42%), Positives = 25/35 (71%), Gaps = 3/35 (8%)

Query: 119 HYANRDGTQYHHGYSYILGWICFCFSFIIGVLYLV 153
           +Y  ++G+   +GYSYIL W+ F F+FI  ++YL+
Sbjct: 57  YYLTKEGS---YGYSYILAWVAFAFTFISSMMYLI 88



 Score = 38.9 bits (89), Expect = 0.002
 Identities = 20/45 (44%), Positives = 25/45 (55%), Gaps = 2/45 (4%)

Query: 1  MLVLLAGIFVVHIATVIMLFVSTIANVWLVSNTVDASVGLWKNCT 45
          MLVLL      HI +  +LF++TI N W V N   A V  W+ CT
Sbjct: 1  MLVLLTFTVAFHITSAALLFIATIDNAWWVGNEFFADV--WRICT 43


>gi|5921465 claudin 10 isoform b [Homo sapiens]
          Length = 228

 Score = 35.8 bits (81), Expect = 0.015
 Identities = 44/176 (25%), Positives = 69/176 (39%), Gaps = 40/176 (22%)

Query: 9   FVVHIATVIMLFVSTIANVWLVSNTVDASV--------GLWKNCTNIS-----CSDSLSY 55
           F+V I+  +++  +   + W VS T+D +V         LWK C   S     C D  S 
Sbjct: 11  FMVSISGWVLVSSTLPTDYWKVS-TIDGTVITTATYWANLWKACVTDSTGVSNCKDFPSM 69

Query: 56  ASEDALKTVQAFMILSIIFCVIALLVFVFQLFTME----------KGNRFFLSGATTLVC 105
            + D    +QA   L I    +     +F LF M+          K     L+G   ++ 
Sbjct: 70  LALDGY--IQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKAKAKIACLAGIVFILS 127

Query: 106 WLCILVGVSIYTSHYANRDGTQ----------YHHGYSYILGWICFCFSFIIGVLY 151
            LC + G S+    YAN+  T+          Y  G +  +GW       I GV++
Sbjct: 128 GLCSMTGCSL----YANKITTEFFDPLFVEQKYELGAALFIGWAGASLCIIGGVIF 179


>gi|122937323 transmembrane protein 202 [Homo sapiens]
          Length = 273

 Score = 35.8 bits (81), Expect = 0.015
 Identities = 27/131 (20%), Positives = 61/131 (46%), Gaps = 8/131 (6%)

Query: 29  LVSNTVDASVGLWKNCTNISCSDSLSYASEDALKTVQAFMILSIIFCVIALLVFVFQLFT 88
           ++ N ++   GLW  C +  C  S +      L+  +AF ++S+ F ++  L ++F  + 
Sbjct: 84  VIKNGLELYAGLWTLCNHELCW-SHTPKPPYYLQYSRAFFLISV-FTILTGLGWLFSSWI 141

Query: 89  MEKG----NRFFLSGATTLVCWLCILVGVSIYTS--HYANRDGTQYHHGYSYILGWICFC 142
           + +G    N        + +   C+L+ ++++ +  H+  RD  +    ++Y L W    
Sbjct: 142 LNRGSMTTNLDLKVSMLSFISATCLLLCLNLFVAQVHWHTRDAMESDLLWTYYLNWCSDI 201

Query: 143 FSFIIGVLYLV 153
           F    G++ L+
Sbjct: 202 FYMFAGIISLL 212


>gi|48255959 plasma membrane calcium ATPase 4 isoform 4a [Homo
            sapiens]
          Length = 1170

 Score = 35.4 bits (80), Expect = 0.020
 Identities = 18/53 (33%), Positives = 31/53 (58%), Gaps = 1/53 (1%)

Query: 62   KTVQAFMILSIIFCVIALLVFVFQLFTMEKGNRFFLSGATTLVCWL-CILVGV 113
            K V + +  +IIFC + L  F+ Q+F +E G + F   + +L  WL C+ +G+
Sbjct: 985  KNVFSGIYRNIIFCSVVLGTFICQIFIVEFGGKPFSCTSLSLSQWLWCLFIGI 1037


>gi|48255957 plasma membrane calcium ATPase 4 isoform 4b [Homo
            sapiens]
          Length = 1205

 Score = 35.4 bits (80), Expect = 0.020
 Identities = 18/53 (33%), Positives = 31/53 (58%), Gaps = 1/53 (1%)

Query: 62   KTVQAFMILSIIFCVIALLVFVFQLFTMEKGNRFFLSGATTLVCWL-CILVGV 113
            K V + +  +IIFC + L  F+ Q+F +E G + F   + +L  WL C+ +G+
Sbjct: 985  KNVFSGIYRNIIFCSVVLGTFICQIFIVEFGGKPFSCTSLSLSQWLWCLFIGI 1037


>gi|24586686 voltage-dependent calcium channel gamma-8 subunit [Homo
           sapiens]
          Length = 425

 Score = 35.0 bits (79), Expect = 0.026
 Identities = 30/106 (28%), Positives = 50/106 (47%), Gaps = 11/106 (10%)

Query: 56  ASEDALKTVQAFMILSIIFCVIALLVFVFQLFT-MEKGNRFFLSGATTL--VCWLCILVG 112
           ++E  L+ V+A  I  I+  ++ LL  V    + + K  R  + GA  L     L  ++G
Sbjct: 117 SAEYLLRVVRASSIFPILSAILLLLGGVCVAASRVYKSKRNIILGAGILFVAAGLSNIIG 176

Query: 113 VSIYTSHYANRDGTQ--------YHHGYSYILGWICFCFSFIIGVL 150
           V +Y S  A   G +        Y +G+S+  G + F  + +IGVL
Sbjct: 177 VIVYISANAGEPGPKRDEEKKNHYSYGWSFYFGGLSFILAEVIGVL 222


>gi|183979973 claudin 19 isoform a [Homo sapiens]
          Length = 224

 Score = 33.5 bits (75), Expect = 0.076
 Identities = 29/122 (23%), Positives = 54/122 (44%), Gaps = 23/122 (18%)

Query: 39  GLWKNCTN-----ISCS--DSLSYASEDALKTVQAFMILSIIFCVIALLVFVFQLFT--- 88
           GLW +C +     + C   DSL  A +  +++ +A M+++++   +A+++ V  +     
Sbjct: 49  GLWMSCASQSTGQVQCKLYDSL-LALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRV 107

Query: 89  -----MEKGNRFFLSGATTLVCWLCILVGVSIY----TSHYANRD---GTQYHHGYSYIL 136
                + KG      GA  ++  LC L  VS Y    T  + N       +Y  G +  +
Sbjct: 108 GDSNPIAKGRVAIAGGALFILAGLCTLTAVSWYATLVTQEFFNPSTPVNARYEFGPALFV 167

Query: 137 GW 138
           GW
Sbjct: 168 GW 169


>gi|124107616 claudin 23 [Homo sapiens]
          Length = 292

 Score = 33.5 bits (75), Expect = 0.076
 Identities = 35/157 (22%), Positives = 62/157 (39%), Gaps = 24/157 (15%)

Query: 16  VIMLFVSTIANVW-----LVSNTVDASV--GLWKNCTNISC-------SDSLSYASEDAL 61
           +++    T+A  W      ++  VD  +  GLW  C   S        +D   Y     +
Sbjct: 18  LLLNLTGTLAPGWRLVKGFLNQPVDVELYQGLWDMCREQSSRERECGQTDQWGYFEAQPV 77

Query: 62  KTVQAFMILSIIFCVIALLVFVFQLFTMEKGNRFFLSGATTLVCWLCILVG---VSIYTS 118
              +A M+ S+   V+ LL+    +   +    F L+G + +V ++  L+G   VS Y  
Sbjct: 78  LVARALMVTSLAATVLGLLLASLGVRCWQDEPNFVLAGLSGVVLFVAGLLGLIPVSWYNH 137

Query: 119 HYANRD-------GTQYHHGYSYILGWICFCFSFIIG 148
              +RD              YS +LG++  C   + G
Sbjct: 138 FLGDRDVLPAPASPVTVQVSYSLVLGYLGSCLLLLGG 174


>gi|10938016 claudin 11 [Homo sapiens]
          Length = 207

 Score = 33.5 bits (75), Expect = 0.076
 Identities = 41/167 (24%), Positives = 68/167 (40%), Gaps = 24/167 (14%)

Query: 9   FVVHIATVIMLFVSTIANVWLVS--------NTVD--ASVGLWKNCTNIS----CSDSLS 54
           FV      I + V+T  N W+V+          +D   S GLW +C   +    C   + 
Sbjct: 11  FVTSFVGWIGVIVTTSTNDWVVTCGYTIPTCRKLDELGSKGLWADCVMATGLYHCKPLVD 70

Query: 55  YASEDA-LKTVQAFMILSIIFCVIALLVFVFQLFTMEKGN--------RFFLSGATTLVC 105
                  ++  +A MI + +  + A+L+ +  L  +  G         R  L+G   ++ 
Sbjct: 71  ILILPGYVQACRALMIAASVLGLPAILLLLTVLPCIRMGQEPGVAKYRRAQLAGVLLILL 130

Query: 106 WLCILVGVSIYTSHYANRDGTQYHHGYSYILGWICFCFSFIIGVLYL 152
            LC LV  +I+    A+R+ T    GYS   GWI      + G + L
Sbjct: 131 ALCALVA-TIWFPVCAHRETTIVSFGYSLYAGWIGAVLCLVGGCVIL 176


>gi|183979975 claudin 19 isoform b [Homo sapiens]
          Length = 211

 Score = 33.5 bits (75), Expect = 0.076
 Identities = 29/122 (23%), Positives = 54/122 (44%), Gaps = 23/122 (18%)

Query: 39  GLWKNCTN-----ISCS--DSLSYASEDALKTVQAFMILSIIFCVIALLVFVFQLFT--- 88
           GLW +C +     + C   DSL  A +  +++ +A M+++++   +A+++ V  +     
Sbjct: 49  GLWMSCASQSTGQVQCKLYDSL-LALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRV 107

Query: 89  -----MEKGNRFFLSGATTLVCWLCILVGVSIY----TSHYANRD---GTQYHHGYSYIL 136
                + KG      GA  ++  LC L  VS Y    T  + N       +Y  G +  +
Sbjct: 108 GDSNPIAKGRVAIAGGALFILAGLCTLTAVSWYATLVTQEFFNPSTPVNARYEFGPALFV 167

Query: 137 GW 138
           GW
Sbjct: 168 GW 169


>gi|5174405 voltage-dependent calcium channel gamma-2 subunit [Homo
           sapiens]
          Length = 323

 Score = 33.1 bits (74), Expect = 0.100
 Identities = 23/97 (23%), Positives = 42/97 (43%), Gaps = 6/97 (6%)

Query: 60  ALKTVQAFMILSIIFCVIALLVFVFQLFTMEKGNRFFLSGATTLVCWLCILVGVSIYTSH 119
           A++    F ILS+I   +  L      F   + N    +G   +   L  ++G+ +Y S 
Sbjct: 100 AVRASSIFPILSVILLFMGGLCIAASEFYKTRHNIILSAGIFFVSAGLSNIIGIIVYISA 159

Query: 120 YA------NRDGTQYHHGYSYILGWICFCFSFIIGVL 150
            A      +     Y +G+S+  G + F  + ++GVL
Sbjct: 160 NAGDPSKSDSKKNSYSYGWSFYFGALSFIIAEMVGVL 196


>gi|5729756 voltage-dependent calcium channel gamma-3 subunit [Homo
           sapiens]
          Length = 315

 Score = 33.1 bits (74), Expect = 0.100
 Identities = 23/96 (23%), Positives = 40/96 (41%), Gaps = 5/96 (5%)

Query: 60  ALKTVQAFMILSIIFCVIALLVFVFQLFTMEKGNRFFLSGATTLVCWLCILVGVSIYTSH 119
           A++    F ILS+       L      F   + N    +G   +   L  ++G+ +Y S 
Sbjct: 100 AVRASSVFPILSVTLLFFGGLCVAASEFHRSRHNVILSAGIFFVSAGLSNIIGIIVYISA 159

Query: 120 YANRDGTQ-----YHHGYSYILGWICFCFSFIIGVL 150
            A   G +     Y +G+S+  G   F  + I+GV+
Sbjct: 160 NAGDPGQRDSKKSYSYGWSFYFGAFSFIIAEIVGVV 195


>gi|153792768 claudin 6 [Homo sapiens]
          Length = 220

 Score = 32.0 bits (71), Expect = 0.22
 Identities = 37/168 (22%), Positives = 65/168 (38%), Gaps = 38/168 (22%)

Query: 6   AGIFVVHIATVIMLFVSTIAN----VWLVSNTVDASV--------GLWKNCTNISCSDSL 53
           AG+ ++ +   ++ +V+ + +    +W V+  +  S+        GLW +C  +  +  +
Sbjct: 4   AGMQILGVVLTLLGWVNGLVSCALPMWKVTAFIGNSIVVAQVVWEGLWMSCV-VQSTGQM 62

Query: 54  SYASEDALKTVQAFMILSIIFCVIALLVFVFQL---------------------FTMEKG 92
                D+L  +   +  +   CVIALLV +F L                       +  G
Sbjct: 63  QCKVYDSLLALPQDLQAARALCVIALLVALFGLLVYLAGAKCTTCVEEKDSKARLVLTSG 122

Query: 93  NRFFLSGATTL--VCWLCILVGVSIYTSHYANRDGTQYHHGYSYILGW 138
             F +SG  TL  VCW    +    Y    A  +  +   G S  LGW
Sbjct: 123 IVFVISGVLTLIPVCWTAHAIIRDFYNPLVA--EAQKRELGASLYLGW 168


>gi|33598916 claudin 10 isoform a [Homo sapiens]
          Length = 226

 Score = 32.0 bits (71), Expect = 0.22
 Identities = 37/163 (22%), Positives = 58/163 (35%), Gaps = 34/163 (20%)

Query: 19  LFVSTIANVWLVSNTVDASV-------GLWKNCTNISCSDSLSYASEDALKT---VQAFM 68
           L  +T +N W V+    + +       GLW NC   +             K    +QA  
Sbjct: 19  LVAATTSNEWKVTTRASSVITATWVYQGLWMNCAGNALGSFHCRPHFTIFKVAGYIQACR 78

Query: 69  ILSIIFCVIALLVFVFQLFTME----------KGNRFFLSGATTLVCWLCILVGVSIYTS 118
            L I    +     +F LF M+          K     L+G   ++  LC + G S+   
Sbjct: 79  GLMIAAVSLGFFGSIFALFGMKCTKVGGSDKAKAKIACLAGIVFILSGLCSMTGCSL--- 135

Query: 119 HYANRDGTQ----------YHHGYSYILGWICFCFSFIIGVLY 151
            YAN+  T+          Y  G +  +GW       I GV++
Sbjct: 136 -YANKITTEFFDPLFVEQKYELGAALFIGWAGASLCIIGGVIF 177


>gi|231569235 claudin 10 isoform a_i1 [Homo sapiens]
          Length = 207

 Score = 31.6 bits (70), Expect = 0.29
 Identities = 36/160 (22%), Positives = 56/160 (35%), Gaps = 47/160 (29%)

Query: 19  LFVSTIANVWLVSNTVDASV-------GLWKNCTNISCSDSLSYASEDALKTVQAFMILS 71
           L  +T +N W V+    + +       GLW NC                   +QA   L 
Sbjct: 19  LVAATTSNEWKVTTRASSVITATWVYQGLWMNCAGY----------------IQACRGLM 62

Query: 72  IIFCVIALLVFVFQLFTME----------KGNRFFLSGATTLVCWLCILVGVSIYTSHYA 121
           I    +     +F LF M+          K     L+G   ++  LC + G S+    YA
Sbjct: 63  IAAVSLGFFGSIFALFGMKCTKVGGSDKAKAKIACLAGIVFILSGLCSMTGCSL----YA 118

Query: 122 NRDGTQ----------YHHGYSYILGWICFCFSFIIGVLY 151
           N+  T+          Y  G +  +GW       I GV++
Sbjct: 119 NKITTEFFDPLFVEQKYELGAALFIGWAGASLCIIGGVIF 158


>gi|239756473 PREDICTED: transmembrane protein 114 [Homo sapiens]
          Length = 223

 Score = 31.2 bits (69), Expect = 0.38
 Identities = 36/151 (23%), Positives = 57/151 (37%), Gaps = 37/151 (24%)

Query: 39  GLWKNCTNIS-CSD----------SLSYASEDALKTVQAFMIL---SIIFCVIA----LL 80
           GLW+ C   S C+           ++S +S   L     F+IL   S+I  V       L
Sbjct: 67  GLWRTCRVQSPCTPLMNPFRLENVTVSESSRQLLTMHGTFVILLPLSLILMVFGGMTGFL 126

Query: 81  VFVFQLFTMEKGNRFFLSGATTLVCWLCILVGVSIYTSHYANR--------------DGT 126
            F+ Q + +       L+G   L   +  L G+S+Y ++ A                D  
Sbjct: 127 SFLLQAYLL-----LLLTGILFLFGAMVTLAGISVYIAYSAAAFREALCLLEEKALLDQV 181

Query: 127 QYHHGYSYILGWICFCFSFIIGVLYLVLRKK 157
               G+S  LGWI F    + G  +L   ++
Sbjct: 182 DISFGWSLALGWISFIAELLTGAAFLAAARE 212


>gi|239752599 PREDICTED: transmembrane protein 114, partial [Homo
           sapiens]
          Length = 217

 Score = 31.2 bits (69), Expect = 0.38
 Identities = 36/151 (23%), Positives = 57/151 (37%), Gaps = 37/151 (24%)

Query: 39  GLWKNCTNIS-CSD----------SLSYASEDALKTVQAFMIL---SIIFCVIA----LL 80
           GLW+ C   S C+           ++S +S   L     F+IL   S+I  V       L
Sbjct: 61  GLWRTCRVQSPCTPLMNPFRLENVTVSESSRQLLTMHGTFVILLPLSLILMVFGGMTGFL 120

Query: 81  VFVFQLFTMEKGNRFFLSGATTLVCWLCILVGVSIYTSHYANR--------------DGT 126
            F+ Q + +       L+G   L   +  L G+S+Y ++ A                D  
Sbjct: 121 SFLLQAYLL-----LLLTGILFLFGAMVTLAGISVYIAYSAAAFREALCLLEEKALLDQV 175

Query: 127 QYHHGYSYILGWICFCFSFIIGVLYLVLRKK 157
               G+S  LGWI F    + G  +L   ++
Sbjct: 176 DISFGWSLALGWISFIAELLTGAAFLAAARE 206


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.334    0.142    0.458 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 4,944,827
Number of Sequences: 37866
Number of extensions: 178859
Number of successful extensions: 936
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 16
Number of HSP's successfully gapped in prelim test: 33
Number of HSP's that attempted gapping in prelim test: 897
Number of HSP's gapped (non-prelim): 55
length of query: 157
length of database: 18,247,518
effective HSP length: 94
effective length of query: 63
effective length of database: 14,688,114
effective search space: 925351182
effective search space used: 925351182
T: 11
A: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 39 (21.6 bits)
S2: 57 (26.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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