Search of human proteins with 4503299

Search of human proteins with 4503299

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4503299 basic helix-loop-helix family, member e40 [Homo
sapiens]
         (412 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4503299 basic helix-loop-helix family, member e40 [Homo sapiens]   841   0.0  
gi|13540521 basic helix-loop-helix domain containing, class B, 3...   236   2e-62
gi|5031763 hairy and enhancer of split 1 [Homo sapiens]                62   9e-10
gi|216548627 hairy and enhancer of split 4 isoform 1 [Homo sapiens]    61   2e-09
gi|10863967 hairy and enhancer of split 4 isoform 2 [Homo sapiens]     60   3e-09
gi|7657154 hairy/enhancer-of-split related with YRPW motif-like ...    53   4e-07
gi|63055047 hairy and enhancer of split homolog 2 [Homo sapiens]       53   4e-07
gi|105990528 hairy/enhancer-of-split related with YRPW motif 1 i...    51   2e-06
gi|6912414 hairy/enhancer-of-split related with YRPW motif 2 [Ho...    50   3e-06
gi|21361763 hairy and enhancer of split 6 isoform a [Homo sapiens]     48   2e-05
gi|105990526 hairy/enhancer-of-split related with YRPW motif 1 i...    47   2e-05
gi|218751874 hairy and enhancer of split 6 isoform b [Homo sapiens]    47   2e-05
gi|71274142 HES/HEY-like transcription factor [Homo sapiens]           46   7e-05
gi|145207994 hairy and enhancer of split 7 [Homo sapiens]              43   5e-04
gi|58219048 hairy and enhancer of split 5 [Homo sapiens]               43   6e-04
gi|66912172 hairy and enhancer of split 3 [Homo sapiens]               42   8e-04
gi|27477113 sterol regulatory element-binding transcription fact...    39   0.007
gi|71852582 aryl hydrocarbon receptor nuclear translocator-like ...    38   0.015
gi|71852580 aryl hydrocarbon receptor nuclear translocator-like ...    38   0.015
gi|42716311 aryl hydrocarbon receptor nuclear translocator-like ...    38   0.015
gi|239743232 PREDICTED: hypothetical protein XP_002342775 [Homo ...    37   0.025
gi|31745180 aryl hydrocarbon receptor nuclear translocator-like ...    37   0.033
gi|146219843 Snf2-related CBP activator protein [Homo sapiens]         37   0.033
gi|26051278 nuclear pore membrane protein 121 [Homo sapiens]           37   0.033
gi|94721344 zinc finger, CW type with PWWP domain 1 [Homo sapiens]     37   0.033
gi|52630419 sterol regulatory element binding transcription fact...    36   0.073
gi|22547195 sterol regulatory element binding transcription fact...    36   0.073
gi|4508017 zinc finger protein 207 isoform a [Homo sapiens]            36   0.073
gi|4505069 MAX dimerization protein 1 [Homo sapiens]                   35   0.095
gi|153791178 ets variant gene 2 [Homo sapiens]                         35   0.095

>gi|4503299 basic helix-loop-helix family, member e40 [Homo sapiens]
          Length = 412

 Score =  841 bits (2172), Expect = 0.0
 Identities = 412/412 (100%), Positives = 412/412 (100%)

Query: 1   MERIPSAQPPPACLPKAPGLEHGDLPGMYPAHMYQVYKSRRGIKRSEDSKETYKLPHRLI 60
           MERIPSAQPPPACLPKAPGLEHGDLPGMYPAHMYQVYKSRRGIKRSEDSKETYKLPHRLI
Sbjct: 1   MERIPSAQPPPACLPKAPGLEHGDLPGMYPAHMYQVYKSRRGIKRSEDSKETYKLPHRLI 60

Query: 61  EKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHVKALTNLIDQQQQKIIA 120
           EKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHVKALTNLIDQQQQKIIA
Sbjct: 61  EKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHVKALTNLIDQQQQKIIA 120

Query: 121 LQSGLQAGELSGRNVETGQEMFCSGFQTCAREVLQYLAKHENTRDLKSSQLVTHLHRVVS 180
           LQSGLQAGELSGRNVETGQEMFCSGFQTCAREVLQYLAKHENTRDLKSSQLVTHLHRVVS
Sbjct: 121 LQSGLQAGELSGRNVETGQEMFCSGFQTCAREVLQYLAKHENTRDLKSSQLVTHLHRVVS 180

Query: 181 ELLQGGTSRKPSDPAPKVMDFKEKPSSPAKGSEGPGKNCVPVIQRTFAHSSGEQSGSDTD 240
           ELLQGGTSRKPSDPAPKVMDFKEKPSSPAKGSEGPGKNCVPVIQRTFAHSSGEQSGSDTD
Sbjct: 181 ELLQGGTSRKPSDPAPKVMDFKEKPSSPAKGSEGPGKNCVPVIQRTFAHSSGEQSGSDTD 240

Query: 241 TDSGYGGESEKGDLRSEQPCFKSDHGRRFTMGERIGAIKQESEEPPTKKNRMQLSDDEGH 300
           TDSGYGGESEKGDLRSEQPCFKSDHGRRFTMGERIGAIKQESEEPPTKKNRMQLSDDEGH
Sbjct: 241 TDSGYGGESEKGDLRSEQPCFKSDHGRRFTMGERIGAIKQESEEPPTKKNRMQLSDDEGH 300

Query: 301 FTSSDLISSPFLGPHPHQPPFCLPFYLIPPSATAYLPMLEKCWYPTSVPVLYPGLNASAA 360
           FTSSDLISSPFLGPHPHQPPFCLPFYLIPPSATAYLPMLEKCWYPTSVPVLYPGLNASAA
Sbjct: 301 FTSSDLISSPFLGPHPHQPPFCLPFYLIPPSATAYLPMLEKCWYPTSVPVLYPGLNASAA 360

Query: 361 ALSSFMNPDKISAPLLMPQRLPSPLPAHPSVDSSVLLQALKPIPPLNLETKD 412
           ALSSFMNPDKISAPLLMPQRLPSPLPAHPSVDSSVLLQALKPIPPLNLETKD
Sbjct: 361 ALSSFMNPDKISAPLLMPQRLPSPLPAHPSVDSSVLLQALKPIPPLNLETKD 412


>gi|13540521 basic helix-loop-helix domain containing, class B, 3
           [Homo sapiens]
          Length = 482

 Score =  236 bits (603), Expect = 2e-62
 Identities = 184/442 (41%), Positives = 236/442 (53%), Gaps = 78/442 (17%)

Query: 20  LEHGDLPGMYPAHMYQVYKSRRGIKRSEDSKETYKLPHRLIEKKRRDRINECIAQLKDLL 79
           LEH D  G+  + +Y   K +R +KR +D+K+TYKLPHRLIEKKRRDRINECIAQLKDLL
Sbjct: 14  LEHRDFIGLDYSSLYMC-KPKRSMKR-DDTKDTYKLPHRLIEKKRRDRINECIAQLKDLL 71

Query: 80  PEHLKLTTLGHLEKAVVLELTLKHVKALTNLIDQQQQKIIALQSGLQAGELSGRNVETGQ 139
           PEHLKLTTLGHLEKAVVLELTLKH+KALT L +QQ QKIIALQ+G ++ +     +++  
Sbjct: 72  PEHLKLTTLGHLEKAVVLELTLKHLKALTALTEQQHQKIIALQNGERSLK---SPIQSDL 128

Query: 140 EMFCSGFQTCAREVLQYLAKHEN--TRDLKSSQLVTHLHRVVSELL---QGGTSRKP--- 191
           + F SGFQTCA+EVLQYL++ E+   R+ +  QL+ HLH V ++ L   Q  T + P   
Sbjct: 129 DAFHSGFQTCAKEVLQYLSRFESWTPREPRCVQLINHLHAVATQFLPTPQLLTQQVPLSK 188

Query: 192 SDPAPKVMDFKEKPSSPAKGSE-GPGKNCVPVIQRTFAHSSGEQSGSDTDTDSGYGGES- 249
              AP        P     G +  P   CVPVIQRT   S+   + +DTDTDSGYGGE+ 
Sbjct: 189 GTGAPSAAGSAAAPCLERAGQKLEPLAYCVPVIQRT-QPSAELAAENDTDTDSGYGGEAE 247

Query: 250 -----EKG--------DLRSEQPCFKSDHGRRFTMGERIG----------AIKQESEEPP 286
                EKG         ++ E P   S   +R  +  R G          A    +   P
Sbjct: 248 ARPDREKGKGAGASRVTIKQEPPGEDSPAPKRMKLDSRGGGSGGGPGGGAAAAAAALLGP 307

Query: 287 TKKNRMQLSDDEGHFTSSDLI-----SSPFLGPHPHQPPFCLPF-YLIPPSATAYLPM-- 338
                  L   +    SS +       +PF  P     PFCLPF +L P +A AY+    
Sbjct: 308 DPAAAAALLRPDAALLSSLVAFGGGGGAPFPQPAAAAAPFCLPFCFLSPSAAAAYVQPFL 367

Query: 339 ----LEKCWYPTSV----PVLYPGLNASAAA----------------LSSFMNPDK---- 370
               LEK  YP +     P+LYPG+ A AAA                LSS ++P      
Sbjct: 368 DKSGLEKYLYPAAAAAPFPLLYPGIPAPAAAAAAAAAAAAAAAAFPCLSSVLSPPPEKAG 427

Query: 371 ISAPLLMPQR---LPSPLPAHP 389
            +A  L+P     L +P P HP
Sbjct: 428 AAAATLLPHEVAPLGAPHPQHP 449


>gi|5031763 hairy and enhancer of split 1 [Homo sapiens]
          Length = 280

 Score = 62.0 bits (149), Expect = 9e-10
 Identities = 50/173 (28%), Positives = 84/173 (48%), Gaps = 25/173 (14%)

Query: 45  RSEDSKETYKLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGH--LEKAVVLELTLK 102
           + + + E  K    ++EK+RR RINE ++QLK L+ + LK  +  H  LEKA +LE+T+K
Sbjct: 27  KPKTASEHRKSSKPIMEKRRRARINESLSQLKTLILDALKKDSSRHSKLEKADILEMTVK 86

Query: 103 HVKALTNLIDQQQQKIIALQSGLQAGELSGRNVETGQEMFCSGFQTCAREVLQYLAKHEN 162
           H++ L     Q+ Q   AL +      + G+        + +GF  C  EV ++L+  E 
Sbjct: 87  HLRNL-----QRAQMTAALSTD---PSVLGK--------YRAGFSECMNEVTRFLSTCEG 130

Query: 163 TRDLKSSQLVTHLHRVVSELLQGGTSRKPSDPAPKVMDFKEKPSSPAKGSEGP 215
                 ++L+ HL   ++++        P  P P +    + P  P  G  GP
Sbjct: 131 VNTEVRTRLLGHLANCMTQI---NAMTYPGQPHPAL----QAPPPPPPGPGGP 176


>gi|216548627 hairy and enhancer of split 4 isoform 1 [Homo sapiens]
          Length = 247

 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 69/233 (29%), Positives = 111/233 (47%), Gaps = 50/233 (21%)

Query: 5   PSAQP---PPACLPKAPGLEHGDLPGMYPAHMYQVYKSRRGIKRSEDSKE---TYKLPHR 58
           PSA P    PA   + P     D P     H  +   SR G++ +   +E   T  +P  
Sbjct: 9   PSASPMAGAPASASRTP-----DKPRSAAEH--RKVGSRPGVRGATGGREGRGTQPVPDP 61

Query: 59  -----LIEKKRRDRINECIAQLKDLLPEHLKLTTLGH--LEKAVVLELTLKHVKALTNLI 111
                ++EK+RR RINE +AQLK L+ + L+  +  H  LEKA +LE+T++H+++L    
Sbjct: 62  QSSKPVMEKRRRARINESLAQLKTLILDALRKESSRHSKLEKADILEMTVRHLRSL---- 117

Query: 112 DQQQQKIIALQSGLQAGELSGRNVETGQEMFCSGFQTCAREVLQYLAKHENTRDLKSSQL 171
             ++ ++ A  S   A  + G+        + +GF  C  EV ++LA  E       S+L
Sbjct: 118 --RRVQVTAALSADPA--VLGK--------YRAGFHECLAEVNRFLAGCEGVPADVRSRL 165

Query: 172 VTHLHRVVSELLQGGTSRKPSD---------PAPKVMDFKEKPSSPAKGSEGP 215
           + HL   + +L   G SR+P+          PAP+V  +  +P  P+ G   P
Sbjct: 166 LGHLAACLRQL---GPSRRPASLSPAAPAEAPAPEV--YAGRPLLPSLGGPFP 213


>gi|10863967 hairy and enhancer of split 4 isoform 2 [Homo sapiens]
          Length = 221

 Score = 60.5 bits (145), Expect = 3e-09
 Identities = 55/182 (30%), Positives = 92/182 (50%), Gaps = 32/182 (17%)

Query: 45  RSEDSKETYKLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGH--LEKAVVLELTLK 102
           +   + E  K    ++EK+RR RINE +AQLK L+ + L+  +  H  LEKA +LE+T++
Sbjct: 27  KPRSAAEHRKSSKPVMEKRRRARINESLAQLKTLILDALRKESSRHSKLEKADILEMTVR 86

Query: 103 HVKALTNLIDQQQQKIIALQSGLQAGELSGRNVETGQEMFCSGFQTCAREVLQYLAKHEN 162
           H+++L      ++ ++ A  S   A  + G+        + +GF  C  EV ++LA  E 
Sbjct: 87  HLRSL------RRVQVTAALSADPA--VLGK--------YRAGFHECLAEVNRFLAGCEG 130

Query: 163 TRDLKSSQLVTHLHRVVSELLQGGTSRKPSD---------PAPKVMDFKEKPSSPAKGSE 213
                 S+L+ HL   + +L   G SR+P+          PAP+V  +  +P  P+ G  
Sbjct: 131 VPADVRSRLLGHLAACLRQL---GPSRRPASLSPAAPAEAPAPEV--YAGRPLLPSLGGP 185

Query: 214 GP 215
            P
Sbjct: 186 FP 187


>gi|7657154 hairy/enhancer-of-split related with YRPW motif-like
           [Homo sapiens]
          Length = 328

 Score = 53.1 bits (126), Expect = 4e-07
 Identities = 47/177 (26%), Positives = 76/177 (42%), Gaps = 30/177 (16%)

Query: 46  SEDSKETYKLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHVK 105
           S    +  K    +IEK+RRDRIN  +++L+ L+P   +      LEKA VL++T+ H+K
Sbjct: 37  SSSQMQARKKRRGIIEKRRRDRINSSLSELRRLVPTAFEKQGSSKLEKAEVLQMTVDHLK 96

Query: 106 AL-----TNLIDQQQQKIIALQSGLQAGELSGRNVETGQEMFCSGFQTCAREVLQYLAKH 160
            L     T   D +   +                     +    GF+ C  EV++YL   
Sbjct: 97  MLHATGGTGFFDARALAV---------------------DFRSIGFRECLTEVIRYLGVL 135

Query: 161 E---NTRDLKSSQLVTHLHRVVSELLQGGTSRKP-SDPAPKVMDFKEKPSSPAKGSE 213
           E   +  D    +L++HL+   +E+    T   P + PA     F   P  PA  ++
Sbjct: 136 EGPSSRADPVRIRLLSHLNSYAAEMEPSPTPTGPLAFPAWPWSFFHSCPGLPALSNQ 192


>gi|63055047 hairy and enhancer of split homolog 2 [Homo sapiens]
          Length = 173

 Score = 53.1 bits (126), Expect = 4e-07
 Identities = 51/182 (28%), Positives = 76/182 (41%), Gaps = 33/182 (18%)

Query: 44  KRSEDSKETYKLPHRLIEKKRRDRINECIAQLKDLLPEHL--KLTTLGHLEKAVVLELTL 101
           +R+ D+ E  K    L+EK+RR RIN+ ++QLK L+   L  + +    LEKA VLE+T+
Sbjct: 5   RRAGDAAELRKSLKPLLEKRRRARINQSLSQLKGLILPLLGRENSNCSKLEKADVLEMTV 64

Query: 102 KHVKALTNLIDQQQQKIIALQSGLQAGELSGRNVETGQEMFC----SGFQTCAREVLQYL 157
           + ++                       EL   +  T   + C     G+  C   + + L
Sbjct: 65  RFLQ-----------------------ELPASSWPTAAPLPCDSYREGYSACVARLARVL 101

Query: 158 AKHENTRDLKSSQLVTHL-HRVVSELLQG---GTSRKPSDPAPKVMDFKEKPSSPAKGSE 213
                     S++L+ HL  R  S  L G   G S  PS PAP      E  S+P     
Sbjct: 102 PACRVLEPAVSARLLEHLWRRAASATLDGGRAGDSSGPSAPAPAPASAPEPASAPVPSPP 161

Query: 214 GP 215
            P
Sbjct: 162 SP 163


>gi|105990528 hairy/enhancer-of-split related with YRPW motif 1
           isoform a [Homo sapiens]
          Length = 304

 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 37/125 (29%), Positives = 61/125 (48%), Gaps = 18/125 (14%)

Query: 59  LIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHVKALTNLIDQQQQKI 118
           +IEK+RRDRIN  +++L+ L+P   +      LEKA +L++T+ H+K L     +     
Sbjct: 56  IIEKRRRDRINNSLSELRRLVPSAFEKQGSAKLEKAEILQMTVDHLKMLHTAGGKGYFDA 115

Query: 119 IALQSGLQAGELSGRNVETGQEMFCSGFQTCAREVLQYLAKHE--NTRDLKSSQLVTHLH 176
            AL    ++                 GF+ C  EV +YL+  E  +  D    +LV+HL+
Sbjct: 116 HALAMDYRS----------------LGFRECLAEVARYLSIIEGLDASDPLRVRLVSHLN 159

Query: 177 RVVSE 181
              S+
Sbjct: 160 NYASQ 164


>gi|6912414 hairy/enhancer-of-split related with YRPW motif 2 [Homo
           sapiens]
          Length = 337

 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 36/119 (30%), Positives = 58/119 (48%), Gaps = 18/119 (15%)

Query: 59  LIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHVKALTNLIDQQQQKI 118
           +IEK+RRDRIN  +++L+ L+P   +      LEKA +L++T+ H+K L     +     
Sbjct: 55  IIEKRRRDRINNSLSELRRLVPTAFEKQGSAKLEKAEILQMTVDHLKMLQATGGKGYFDA 114

Query: 119 IALQSGLQAGELSGRNVETGQEMFCSGFQTCAREVLQYLAKHE--NTRDLKSSQLVTHL 175
            AL                  +    GF+ C  EV +YL+  E  ++ D    +LV+HL
Sbjct: 115 HAL----------------AMDFMSIGFRECLTEVARYLSSVEGLDSSDPLRVRLVSHL 157


>gi|21361763 hairy and enhancer of split 6 isoform a [Homo sapiens]
          Length = 224

 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 48/184 (26%), Positives = 76/184 (41%), Gaps = 30/184 (16%)

Query: 44  KRSEDSKETY---KLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELT 100
           +  ED  ET    K    L+EKKRR RINE + +L+ LL           LE A VLELT
Sbjct: 14  REDEDGWETRGDRKARKPLVEKKRRARINESLQELRLLL---AGAEVQAKLENAEVLELT 70

Query: 101 LKHVKALTNLIDQQQQKIIALQSGLQAGELSGRNVETGQEMFCSGFQTCAREVLQYLAKH 160
           ++ V+ +     ++++++ A  S                E F +G+  C  EV  +++  
Sbjct: 71  VRRVQGVLRGRAREREQLQAEAS----------------ERFAAGYIQCMHEVHTFVSTC 114

Query: 161 ENTRDLKSSQLVTHLHRVV--------SELLQGGTSRKPSDPAPKVMDFKEKPSSPAKGS 212
           +      +++L+ HL   +         +LL    +  P  P          P SP    
Sbjct: 115 QAIDATVAAELLNHLLESMPLREGSSFQDLLGDALAGPPRAPGRSGWPAGGAPGSPIPSP 174

Query: 213 EGPG 216
            GPG
Sbjct: 175 PGPG 178


>gi|105990526 hairy/enhancer-of-split related with YRPW motif 1
           isoform b [Homo sapiens]
          Length = 308

 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 37/129 (28%), Positives = 62/129 (48%), Gaps = 22/129 (17%)

Query: 59  LIEKKRRDRINECIAQLKDLLPEHLKLTTL----GHLEKAVVLELTLKHVKALTNLIDQQ 114
           +IEK+RRDRIN  +++L+ L+P   +   +      LEKA +L++T+ H+K L     + 
Sbjct: 56  IIEKRRRDRINNSLSELRRLVPSAFEKQVMEQGSAKLEKAEILQMTVDHLKMLHTAGGKG 115

Query: 115 QQKIIALQSGLQAGELSGRNVETGQEMFCSGFQTCAREVLQYLAKHE--NTRDLKSSQLV 172
                AL    ++                 GF+ C  EV +YL+  E  +  D    +LV
Sbjct: 116 YFDAHALAMDYRS----------------LGFRECLAEVARYLSIIEGLDASDPLRVRLV 159

Query: 173 THLHRVVSE 181
           +HL+   S+
Sbjct: 160 SHLNNYASQ 168


>gi|218751874 hairy and enhancer of split 6 isoform b [Homo sapiens]
          Length = 222

 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 48/184 (26%), Positives = 76/184 (41%), Gaps = 32/184 (17%)

Query: 44  KRSEDSKETY---KLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELT 100
           +  ED  ET    K    L+EKKRR RINE + +L+ LL           LE A VLELT
Sbjct: 14  REDEDGWETRGDRKARKPLVEKKRRARINESLQELRLLL-----AGAEAKLENAEVLELT 68

Query: 101 LKHVKALTNLIDQQQQKIIALQSGLQAGELSGRNVETGQEMFCSGFQTCAREVLQYLAKH 160
           ++ V+ +     ++++++ A  S                E F +G+  C  EV  +++  
Sbjct: 69  VRRVQGVLRGRAREREQLQAEAS----------------ERFAAGYIQCMHEVHTFVSTC 112

Query: 161 ENTRDLKSSQLVTHLHRVV--------SELLQGGTSRKPSDPAPKVMDFKEKPSSPAKGS 212
           +      +++L+ HL   +         +LL    +  P  P          P SP    
Sbjct: 113 QAIDATVAAELLNHLLESMPLREGSSFQDLLGDALAGPPRAPGRSGWPAGGAPGSPIPSP 172

Query: 213 EGPG 216
            GPG
Sbjct: 173 PGPG 176


>gi|71274142 HES/HEY-like transcription factor [Homo sapiens]
          Length = 327

 Score = 45.8 bits (107), Expect = 7e-05
 Identities = 48/226 (21%), Positives = 82/226 (36%), Gaps = 57/226 (25%)

Query: 38  KSRRGIKRSEDSKETYKLPHRLIEKKRRDRINECIAQLKDLLP----------------- 80
           K   G    E+S+    + H++IEK+RRDRIN C+ +L   +P                 
Sbjct: 40  KCPHGTLSVEESRVRTPVSHKVIEKRRRDRINRCLNELGKTVPMALAKQGEPQEALAQIR 99

Query: 81  ------------------------EHLKLTTLGHLEKAVVLELTLKHVKALTNLIDQQQQ 116
                                     L L + G LEKA +LE+T+++++AL +       
Sbjct: 100 SRVRSLVLSSATVPDQQALGRCEGPFLLLQSSGKLEKAEILEMTVQYLRALHS------- 152

Query: 117 KIIALQSGLQAGELSGRNVETGQEMFCSGFQTCAREVLQYLAKHE--NTRDLKSSQLVTH 174
                 +    G      +      F  G+  C + ++ YL   E   T+D K ++++  
Sbjct: 153 ------ADFPRGREKAELLAEFANYFHYGYHECMKNLVHYLTTVERMETKDTKYARILAF 206

Query: 175 LHRVVSELLQGGTSRKPSDPAPKVMDFKEKPSSPAKGSEGPGKNCV 220
           L        +       S P P    ++  P+ P      PG+  V
Sbjct: 207 LQSKARLGAEPAFPPLGSLPEPD-FSYQLHPAGPEFAGHSPGEAAV 251


>gi|145207994 hairy and enhancer of split 7 [Homo sapiens]
          Length = 225

 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 43/166 (25%), Positives = 75/166 (45%), Gaps = 20/166 (12%)

Query: 48  DSKETYKLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGH--LEKAVVLELTLKHVK 105
           ++++  K+   L+EK+RRDRIN  + +L+ LL E  +   L +  LEKA +LE  + +++
Sbjct: 8   ENRDGPKMLKPLVEKRRRDRINRSLEELRLLLLERTRDQNLRNPKLEKAEILEFAVGYLR 67

Query: 106 ALTNLIDQQQQKIIALQSGLQAGELSGRNVETGQEMFCSGFQTCAREVLQYLAKHENTRD 165
                     ++      G+    +  ++ E     + SGF+ C   +L+  A   +   
Sbjct: 68  ----------ERSRVEPPGVPRSPV--QDAEALASCYLSGFREC---LLRLAAFAHDASP 112

Query: 166 LKSSQLVTHLHRVVSELLQGGTSRKPSDPAPKVMDFKEKPSSPAKG 211
              +QL + LH     L       KP DP P        P++PA G
Sbjct: 113 AARAQLFSALH---GYLRPKPPRPKPVDPRPPAPRPSLDPAAPALG 155


>gi|58219048 hairy and enhancer of split 5 [Homo sapiens]
          Length = 166

 Score = 42.7 bits (99), Expect = 6e-04
 Identities = 35/115 (30%), Positives = 51/115 (44%), Gaps = 26/115 (22%)

Query: 50  KETYKLPHRLIEKKRRDRINECIAQLKDLL-PEHLKLTTLGHLEKAVVLELT---LKHVK 105
           KE  +L   ++EK RRDRIN  I QLK LL  E  +      LEKA +LE+    LKH K
Sbjct: 14  KEKNRLRKPVVEKMRRDRINSSIEQLKLLLEQEFARHQPNSKLEKADILEMAVSYLKHSK 73

Query: 106 ALTNLIDQQQQKIIALQSGLQAGELSGRNVETGQEMFCSGFQTCAREVLQYLAKH 160
           A                       ++    ++  + +  G+  C +E +Q+L  H
Sbjct: 74  AF----------------------VAAAGPKSLHQDYSEGYSWCLQEAVQFLTLH 106


>gi|66912172 hairy and enhancer of split 3 [Homo sapiens]
          Length = 186

 Score = 42.4 bits (98), Expect = 8e-04
 Identities = 24/51 (47%), Positives = 34/51 (66%), Gaps = 1/51 (1%)

Query: 60  IEKKRRDRINECIAQLKDLLPEHLK-LTTLGHLEKAVVLELTLKHVKALTN 109
           +EKKRR RIN  + QLK LL +H         LEKA +LEL++K++++L N
Sbjct: 1   MEKKRRARINVSLEQLKSLLEKHYSHQIRKRKLEKADILELSVKYMRSLQN 51


>gi|27477113 sterol regulatory element-binding transcription factor
           2 [Homo sapiens]
          Length = 1141

 Score = 39.3 bits (90), Expect = 0.007
 Identities = 27/90 (30%), Positives = 48/90 (53%), Gaps = 6/90 (6%)

Query: 42  GIKRSEDSKE-TYKLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELT 100
           G+K+ E  KE   +  H +IEK+ R  IN+ I +LKDL+     + T   + K+ VL   
Sbjct: 319 GVKQLEPPKEGERRTTHNIIEKRYRSSINDKIIELKDLV-----MGTDAKMHKSGVLRKA 373

Query: 101 LKHVKALTNLIDQQQQKIIALQSGLQAGEL 130
           + ++K L  +  + +Q+ + L+   Q  +L
Sbjct: 374 IDYIKYLQQVNHKLRQENMVLKLANQKNKL 403


>gi|71852582 aryl hydrocarbon receptor nuclear translocator-like
           isoform b [Homo sapiens]
          Length = 582

 Score = 38.1 bits (87), Expect = 0.015
 Identities = 45/174 (25%), Positives = 71/174 (40%), Gaps = 29/174 (16%)

Query: 57  HRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHVKAL--------- 107
           H  IEK+RRD++N  I +L  L+P    ++    L+K  VL + ++H+K L         
Sbjct: 34  HSQIEKRRRDKMNSFIDELASLVPTCNAMSR--KLDKLTVLRMAVQHMKTLRGATNPYTE 91

Query: 108 -----TNLIDQQQQKIIALQSGLQAGELSGRNVETGQEMFCSGFQTCAREVLQYLAKHEN 162
                T L D + + +I   +    G L     + G+ +F S        V + L   +N
Sbjct: 92  ANYKPTFLSDDELKHLILRAAD---GFLFVVGCDRGKILFVS------ESVFKILNYSQN 142

Query: 163 TRDLKSSQLVTHLHRVVSELLQGGTSRKPSDPAPKVMDFKEKPSSPAKGSEGPG 216
             DL    L  +LH    ++ +       SD AP+      K   P K    PG
Sbjct: 143 --DLIGQSLFDYLH--PKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPG 192


>gi|71852580 aryl hydrocarbon receptor nuclear translocator-like
           isoform a [Homo sapiens]
          Length = 625

 Score = 38.1 bits (87), Expect = 0.015
 Identities = 45/174 (25%), Positives = 71/174 (40%), Gaps = 29/174 (16%)

Query: 57  HRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHVKAL--------- 107
           H  IEK+RRD++N  I +L  L+P    ++    L+K  VL + ++H+K L         
Sbjct: 77  HSQIEKRRRDKMNSFIDELASLVPTCNAMSR--KLDKLTVLRMAVQHMKTLRGATNPYTE 134

Query: 108 -----TNLIDQQQQKIIALQSGLQAGELSGRNVETGQEMFCSGFQTCAREVLQYLAKHEN 162
                T L D + + +I   +    G L     + G+ +F S        V + L   +N
Sbjct: 135 ANYKPTFLSDDELKHLILRAAD---GFLFVVGCDRGKILFVS------ESVFKILNYSQN 185

Query: 163 TRDLKSSQLVTHLHRVVSELLQGGTSRKPSDPAPKVMDFKEKPSSPAKGSEGPG 216
             DL    L  +LH    ++ +       SD AP+      K   P K    PG
Sbjct: 186 --DLIGQSLFDYLH--PKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPG 235


>gi|42716311 aryl hydrocarbon receptor nuclear translocator-like
           isoform a [Homo sapiens]
          Length = 625

 Score = 38.1 bits (87), Expect = 0.015
 Identities = 45/174 (25%), Positives = 71/174 (40%), Gaps = 29/174 (16%)

Query: 57  HRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHVKAL--------- 107
           H  IEK+RRD++N  I +L  L+P    ++    L+K  VL + ++H+K L         
Sbjct: 77  HSQIEKRRRDKMNSFIDELASLVPTCNAMSR--KLDKLTVLRMAVQHMKTLRGATNPYTE 134

Query: 108 -----TNLIDQQQQKIIALQSGLQAGELSGRNVETGQEMFCSGFQTCAREVLQYLAKHEN 162
                T L D + + +I   +    G L     + G+ +F S        V + L   +N
Sbjct: 135 ANYKPTFLSDDELKHLILRAAD---GFLFVVGCDRGKILFVS------ESVFKILNYSQN 185

Query: 163 TRDLKSSQLVTHLHRVVSELLQGGTSRKPSDPAPKVMDFKEKPSSPAKGSEGPG 216
             DL    L  +LH    ++ +       SD AP+      K   P K    PG
Sbjct: 186 --DLIGQSLFDYLH--PKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPG 235


>gi|239743232 PREDICTED: hypothetical protein XP_002342775 [Homo
           sapiens]
          Length = 834

 Score = 37.4 bits (85), Expect = 0.025
 Identities = 56/245 (22%), Positives = 89/245 (36%), Gaps = 25/245 (10%)

Query: 184 QGGTSRKP-SDPAPKVMDFKEKPSSPAKGSEGPGKNCVPVIQRTFAHSSGEQSGSDT--- 239
           + G S  P S PA       E+P+   +  E    +           S GE++   T   
Sbjct: 13  RNGPSSSPFSSPASSRSQTPERPAKKIREEEMCHHSSSSTPLAADKESQGEKAADTTPRK 72

Query: 240 -DTDSGYGGESEKGDLRSEQPCFKSDHGRRFTM------GERIGAIKQESEEPPTKKNRM 292
               +        G  + +     S  G + T+      G  I A   + E+  + +   
Sbjct: 73  KQNSNSQSTPGSSGQRKRKVQLLPSRRGEQLTLPPPPQLGYSITAEDLDLEKKASLQWFN 132

Query: 293 QLSDDEGHFTSSDLISSP------FLGPHPHQPPFCLPFYLIPPSATAYLPMLEKCWYPT 346
           Q  +D+    S+ +  +P      F    P   P   P  L+ PS    L  L+K   P 
Sbjct: 133 QALEDKSDAASNSVTETPPITQPSFTFTLPAAAPASPPTSLLAPSTNPLLESLKKMQTPP 192

Query: 347 SVPVLYPGLNASAAALSSFMNPDK---ISAPLLMPQRLPSPLPAHPSVDSS--VLLQALK 401
           S+P   P   ++ AA +  ++P K   +  PL + Q  P  L   PS DS+    L  L 
Sbjct: 193 SLP---PCPESAGAATTEALSPPKTPNLLPPLGLSQSGPPGLLPSPSFDSNPPTTLLGLI 249

Query: 402 PIPPL 406
           P P +
Sbjct: 250 PAPSM 254


>gi|31745180 aryl hydrocarbon receptor nuclear translocator-like 2
           [Homo sapiens]
          Length = 636

 Score = 37.0 bits (84), Expect = 0.033
 Identities = 21/71 (29%), Positives = 38/71 (53%), Gaps = 7/71 (9%)

Query: 45  RSEDSKETYKLP-----HRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLEL 99
           R ED +   K+      H   EK+RRD++N  I +L  ++P+   +     L+K  VL +
Sbjct: 95  RVEDGEHQVKMKAFREAHSQTEKRRRDKMNNLIEELSAMIPQCNPMAR--KLDKLTVLRM 152

Query: 100 TLKHVKALTNL 110
            ++H+++L  L
Sbjct: 153 AVQHLRSLKGL 163


>gi|146219843 Snf2-related CBP activator protein [Homo sapiens]
          Length = 3230

 Score = 37.0 bits (84), Expect = 0.033
 Identities = 31/97 (31%), Positives = 40/97 (41%), Gaps = 11/97 (11%)

Query: 312  LGPHPHQPPFCLPFYLIPPSATAYLPMLEKCWYPTSVPVLYPGLN--ASAAALSSFMNPD 369
            L P P  P   LP     P A   L   +     T VPV+ P      S A+ S    P 
Sbjct: 1598 LAPSPAPPLAPLPVLAPSPGAAPVLASSQ-----TPVPVMAPSSTPGTSLASASPVPAPT 1652

Query: 370  KISAP----LLMPQRLPSPLPAHPSVDSSVLLQALKP 402
             + AP     ++P  +PSPLP+  S  +  L  AL P
Sbjct: 1653 PVLAPSSTQTMLPAPVPSPLPSPASTQTLALAPALAP 1689


>gi|26051278 nuclear pore membrane protein 121 [Homo sapiens]
          Length = 984

 Score = 37.0 bits (84), Expect = 0.033
 Identities = 59/253 (23%), Positives = 93/253 (36%), Gaps = 26/253 (10%)

Query: 177 RVVSELLQ-GGTSRKP-SDPAPKVMDFKEKPSSPAKGSEGPGKNCVPVIQRTFAHSSGEQ 234
           R +S+L +  G S  P S PA       E+P+   +  E    +           S GE+
Sbjct: 156 RGISQLWKRNGPSSSPFSSPASSRSQTPERPAKKIREEELCHHSSSSTPLAADRESQGEK 215

Query: 235 SGSDT----DTDSGYGGESEKGDLRSEQPCFKSDHGRRFTM------GERIGAIKQESEE 284
           +   T       +        G  + +     S  G + T+      G  I A   + E+
Sbjct: 216 AADTTPRKKQNSNSQSTPGSSGQRKRKVQLLPSRRGEQLTLPPPPQLGYSITAEDLDLEK 275

Query: 285 PPTKKNRMQLSDDEGHFTSSDLISSP------FLGPHPHQPPFCLPFYLIPPSATAYLPM 338
             + +   Q  +D+    S+ +  +P      F    P   P   P  L+ PS    L  
Sbjct: 276 KASLQWFNQALEDKSDAASNSVTETPPITQPSFTFTLPAAAPASPPTSLLAPSTNPLLES 335

Query: 339 LEKCWYPTSVPVLYPGLNASAAALSSFMNPDK---ISAPLLMPQRLPSPLPAHPSVDSS- 394
           L+K   P S+P   P   ++ AA +  ++P K   +  PL + Q  P  L   PS DS  
Sbjct: 336 LKKMQTPPSLP---PCPESAGAATTEALSPPKTPSLLPPLGLSQSGPPGLLPSPSFDSKP 392

Query: 395 -VLLQALKPIPPL 406
              L  L P P +
Sbjct: 393 PTTLLGLIPAPSM 405


>gi|94721344 zinc finger, CW type with PWWP domain 1 [Homo sapiens]
          Length = 648

 Score = 37.0 bits (84), Expect = 0.033
 Identities = 56/245 (22%), Positives = 95/245 (38%), Gaps = 26/245 (10%)

Query: 5   PSAQPPPACLPKAPGLEHGDLPGMY-PAHMYQVYKSRRGIKRSEDSKETYKLPHRLIEKK 63
           P AQ   + LP +P     + PG+  P    ++   +  +K+ E+      +P R  EKK
Sbjct: 21  PPAQKSYSLLPCSPNSPKEETPGISSPETEARISLPKASLKKKEEKATMKNVPSREQEKK 80

Query: 64  RRDRINECIAQLKDLLPEHLKLTTLGHLE-KAVVLELTLKHVKALTNLIDQQQ----QKI 118
           R+ +IN+   Q +    E   LT     E   +VL+ +L+    + + +D  +    Q +
Sbjct: 81  RKAQINK---QAEKKEKEKSSLTNAEFEEIVQIVLQKSLQECLGMGSGLDFAETSCAQPV 137

Query: 119 IALQSGLQAG---------ELSGRNVETGQEMFCSGFQTCAREV-LQYLAKHENTRDLKS 168
           ++ QS  + G           +G  V   QE+  S     A E+    L + +     K 
Sbjct: 138 VSTQSDKEPGITASATDTDNANGEEVPHTQEISVSWEGEAAPEIRTSKLGQPDPAPSKKK 197

Query: 169 SQLVT------HLHRVVSELLQGGTSRKPSDPAPKVMDFKEKPSSPAKGSEGPGKNCVPV 222
           S  +T        H  V E  QGG   +  D   K +    +     KG       C+  
Sbjct: 198 SNRLTLSKRKKEAHEKV-EKTQGGHEHRQEDRLKKTVQDHSQIRDQQKGEISGFGQCLVW 256

Query: 223 IQRTF 227
           +Q +F
Sbjct: 257 VQCSF 261


>gi|52630419 sterol regulatory element binding transcription factor
           1 isoform a [Homo sapiens]
          Length = 1177

 Score = 35.8 bits (81), Expect = 0.073
 Identities = 22/80 (27%), Positives = 43/80 (53%), Gaps = 5/80 (6%)

Query: 46  SEDSKETYKLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHVK 105
           S  S+   +  H  IEK+ R  IN+ I +LKDL+     + T   L K+ VL   + +++
Sbjct: 347 SAQSRGEKRTAHNAIEKRYRSSINDKIIELKDLV-----VGTEAKLNKSAVLRKAIDYIR 401

Query: 106 ALTNLIDQQQQKIIALQSGL 125
            L +   + +Q+ ++L++ +
Sbjct: 402 FLQHSNQKLKQENLSLRTAV 421


>gi|22547195 sterol regulatory element binding transcription factor
           1 isoform b [Homo sapiens]
          Length = 1147

 Score = 35.8 bits (81), Expect = 0.073
 Identities = 22/80 (27%), Positives = 43/80 (53%), Gaps = 5/80 (6%)

Query: 46  SEDSKETYKLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHVK 105
           S  S+   +  H  IEK+ R  IN+ I +LKDL+     + T   L K+ VL   + +++
Sbjct: 317 SAQSRGEKRTAHNAIEKRYRSSINDKIIELKDLV-----VGTEAKLNKSAVLRKAIDYIR 371

Query: 106 ALTNLIDQQQQKIIALQSGL 125
            L +   + +Q+ ++L++ +
Sbjct: 372 FLQHSNQKLKQENLSLRTAV 391


>gi|4508017 zinc finger protein 207 isoform a [Homo sapiens]
          Length = 478

 Score = 35.8 bits (81), Expect = 0.073
 Identities = 37/150 (24%), Positives = 55/150 (36%), Gaps = 18/150 (12%)

Query: 271 MGERIGAIKQESEEPPTKKNRMQLSDDEGHFTSSDLISSPFLGPHPHQ------PPFCLP 324
           M ER   ++Q+++E   KK +    DD   +   D  +S    P P Q      PP   P
Sbjct: 90  MDERRRLLEQKTQESQKKKQQ----DDSDEYDDDDSAASTSFQPQPVQPQQGYIPPMAQP 145

Query: 325 FYLIPPSATAYLPMLEKCW-----YPTSVPVLYPGLNASAAALSSFMNPDKISAPLL--M 377
                P A    P +             +P + PG+      +   M P     PL+  M
Sbjct: 146 GLPPVPGAPGMPPGIPPLMPGVPPLMPGMPPVMPGMPPGMMPMGGMMPPGPGIPPLMPGM 205

Query: 378 PQRLPSPLPAHPSVDSSVLLQALKPIPPLN 407
           P  +P P+P  P +      QA+     LN
Sbjct: 206 PPGMPPPVP-RPGIPPMTQAQAVSAPGILN 234


>gi|4505069 MAX dimerization protein 1 [Homo sapiens]
          Length = 221

 Score = 35.4 bits (80), Expect = 0.095
 Identities = 33/108 (30%), Positives = 50/108 (46%), Gaps = 17/108 (15%)

Query: 21  EHGDLPGMYPAHMYQVYKSRRGIKRSEDSKE---TYKLPHRLIEKKRRDRINECIAQLKD 77
           EHG     Y + +    K R  +KR   SK+   + +  H  +EK RR  +  C+ +LK 
Sbjct: 27  EHG-----YASMLPYNNKDRDALKRRNKSKKNNSSSRSTHNEMEKNRRAHLRLCLEKLKG 81

Query: 78  LL---PEHLKLTTLGHLEKAVVLELTLKHVKALTNLIDQQQQKIIALQ 122
           L+   PE  + TTL  L KA +      H+K L +   +   +I  LQ
Sbjct: 82  LVPLGPESSRHTTLSLLTKAKL------HIKKLEDCDRKAVHQIDQLQ 123


>gi|153791178 ets variant gene 2 [Homo sapiens]
          Length = 342

 Score = 35.4 bits (80), Expect = 0.095
 Identities = 18/44 (40%), Positives = 25/44 (56%), Gaps = 1/44 (2%)

Query: 208 PAKGSEGP-GKNCVPVIQRTFAHSSGEQSGSDTDTDSGYGGESE 250
           PA GSEG  G+NCVPV     + S  + +GS+T  D   G + +
Sbjct: 120 PAAGSEGAAGQNCVPVAGEATSWSRAQAAGSNTSWDCSVGPDGD 163


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.133    0.394 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,904,171
Number of Sequences: 37866
Number of extensions: 1005899
Number of successful extensions: 3588
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 41
Number of HSP's successfully gapped in prelim test: 120
Number of HSP's that attempted gapping in prelim test: 3463
Number of HSP's gapped (non-prelim): 240
length of query: 412
length of database: 18,247,518
effective HSP length: 105
effective length of query: 307
effective length of database: 14,271,588
effective search space: 4381377516
effective search space used: 4381377516
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.