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Search of human proteins with 4502753
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4502753 cyclin-dependent kinase inhibitor 2D [Homo sapiens]
(166 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4502753 cyclin-dependent kinase inhibitor 2D [Homo sapiens] 324 2e-89
gi|17981702 cyclin-dependent kinase inhibitor 2D [Homo sapiens] 324 2e-89
gi|17981699 cyclin-dependent kinase inhibitor 2C [Homo sapiens] 132 2e-31
gi|4502751 cyclin-dependent kinase inhibitor 2C [Homo sapiens] 132 2e-31
gi|17981694 cyclin-dependent kinase inhibitor 2B isoform 1 [Homo... 103 7e-23
gi|4502749 cyclin-dependent kinase inhibitor 2A isoform 1 [Homo ... 102 2e-22
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 89 2e-18
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 84 6e-17
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 84 6e-17
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 84 6e-17
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 79 1e-15
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 79 1e-15
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 79 1e-15
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 79 1e-15
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 79 1e-15
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 72 2e-13
gi|218505706 ankyrin repeat and SOCS box-containing 14 isoform 1... 72 2e-13
gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiqu... 72 3e-13
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 71 5e-13
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 70 6e-13
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 70 8e-13
gi|39812133 ankyrin repeat domain 2 isoform a [Homo sapiens] 70 1e-12
gi|18079216 CASK interacting protein 1 [Homo sapiens] 68 4e-12
gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens] 68 4e-12
gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens] 68 4e-12
gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens] 68 4e-12
gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens] 68 4e-12
gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens] 68 4e-12
gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens] 68 4e-12
gi|38327522 cardiac ankyrin repeat protein [Homo sapiens] 68 4e-12
>gi|4502753 cyclin-dependent kinase inhibitor 2D [Homo sapiens]
Length = 166
Score = 324 bits (830), Expect = 2e-89
Identities = 166/166 (100%), Positives = 166/166 (100%)
Query: 1 MLLEEVRAGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALEL 60
MLLEEVRAGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALEL
Sbjct: 1 MLLEEVRAGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALEL 60
Query: 61 LKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHT 120
LKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHT
Sbjct: 61 LKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHT 120
Query: 121 AVVSFLAAESDLHRRDARGLTPLELALQRGAQDLVDILQGHMVAPL 166
AVVSFLAAESDLHRRDARGLTPLELALQRGAQDLVDILQGHMVAPL
Sbjct: 121 AVVSFLAAESDLHRRDARGLTPLELALQRGAQDLVDILQGHMVAPL 166
>gi|17981702 cyclin-dependent kinase inhibitor 2D [Homo sapiens]
Length = 166
Score = 324 bits (830), Expect = 2e-89
Identities = 166/166 (100%), Positives = 166/166 (100%)
Query: 1 MLLEEVRAGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALEL 60
MLLEEVRAGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALEL
Sbjct: 1 MLLEEVRAGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALEL 60
Query: 61 LKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHT 120
LKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHT
Sbjct: 61 LKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHT 120
Query: 121 AVVSFLAAESDLHRRDARGLTPLELALQRGAQDLVDILQGHMVAPL 166
AVVSFLAAESDLHRRDARGLTPLELALQRGAQDLVDILQGHMVAPL
Sbjct: 121 AVVSFLAAESDLHRRDARGLTPLELALQRGAQDLVDILQGHMVAPL 166
>gi|17981699 cyclin-dependent kinase inhibitor 2C [Homo sapiens]
Length = 168
Score = 132 bits (331), Expect = 2e-31
Identities = 71/155 (45%), Positives = 104/155 (67%), Gaps = 3/155 (1%)
Query: 9 GDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALELLKQGASPN 68
G+ L+ AAARGD++++ LL V+ +A N FG+TALQVM G+ IA LL +GA+P+
Sbjct: 6 GNELASAAARGDLEQLTSLLQNN-VNVNAQNGFGRTALQVMKLGNPEIARRLLLRGANPD 64
Query: 69 VQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLA- 127
++D +G + +HDAAR GFLDTL+ L+E ADVN+ D G LP+HLA +EGH VV FL
Sbjct: 65 LKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVK 124
Query: 128 -AESDLHRRDARGLTPLELALQRGAQDLVDILQGH 161
S++ R+ +G T +LA G ++V ++Q +
Sbjct: 125 HTASNVGHRNHKGDTACDLARLYGRNEVVSLMQAN 159
>gi|4502751 cyclin-dependent kinase inhibitor 2C [Homo sapiens]
Length = 168
Score = 132 bits (331), Expect = 2e-31
Identities = 71/155 (45%), Positives = 104/155 (67%), Gaps = 3/155 (1%)
Query: 9 GDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALELLKQGASPN 68
G+ L+ AAARGD++++ LL V+ +A N FG+TALQVM G+ IA LL +GA+P+
Sbjct: 6 GNELASAAARGDLEQLTSLLQNN-VNVNAQNGFGRTALQVMKLGNPEIARRLLLRGANPD 64
Query: 69 VQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLA- 127
++D +G + +HDAAR GFLDTL+ L+E ADVN+ D G LP+HLA +EGH VV FL
Sbjct: 65 LKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVK 124
Query: 128 -AESDLHRRDARGLTPLELALQRGAQDLVDILQGH 161
S++ R+ +G T +LA G ++V ++Q +
Sbjct: 125 HTASNVGHRNHKGDTACDLARLYGRNEVVSLMQAN 159
>gi|17981694 cyclin-dependent kinase inhibitor 2B isoform 1 [Homo
sapiens]
Length = 138
Score = 103 bits (257), Expect = 7e-23
Identities = 60/116 (51%), Positives = 75/116 (64%), Gaps = 2/116 (1%)
Query: 12 LSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALELLKQGASPNVQD 71
L+ AAARG V++VR+LL P+ +NRFG+ A+QVMM GS +A LL GA PN D
Sbjct: 18 LASAAARGLVEKVRQLLEAG-ADPNGVNRFGRRAIQVMMMGSARVAELLLLHGAEPNCAD 76
Query: 72 TSG-TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFL 126
+ T PVHDAAR GFLDTL VL GA ++V D G LP+ LA + GH V +L
Sbjct: 77 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYL 132
>gi|4502749 cyclin-dependent kinase inhibitor 2A isoform 1 [Homo
sapiens]
Length = 156
Score = 102 bits (253), Expect = 2e-22
Identities = 66/150 (44%), Positives = 84/150 (56%), Gaps = 6/150 (4%)
Query: 8 AGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALELLKQGASP 67
+ D L+ AAARG V+EVR LL + P+A N +G+ +QVMM GS +A LL GA P
Sbjct: 12 SADWLATAAARGRVEEVRALLEAGAL-PNAPNSYGRRPIQVMMMGSARVAELLLLHGAEP 70
Query: 68 NVQDTSG-TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFL 126
N D + T PVHDAAR GFLDTL VL GA ++V D G LP+ LA + GH V +L
Sbjct: 71 NCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL 130
Query: 127 AAESDLHRRDARGLTPLELALQRGAQDLVD 156
A + RG + G D+ D
Sbjct: 131 RAAAG----GTRGSNHARIDAAEGPSDIPD 156
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 88.6 bits (218), Expect = 2e-18
Identities = 54/145 (37%), Positives = 80/145 (55%), Gaps = 2/145 (1%)
Query: 16 AARGDVQEVRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQGASPNVQDTSG 74
AA+ EV LL ++ PDA + G T L V + + +AL LL QGASP+ +G
Sbjct: 572 AAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNG 631
Query: 75 TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVS-FLAAESDLH 133
+P+H AA+ +D L+E+GAD N G +HLA QEGH +VS L ++++
Sbjct: 632 YTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVN 691
Query: 134 RRDARGLTPLELALQRGAQDLVDIL 158
+ GLTPL LA Q ++ ++L
Sbjct: 692 LSNKSGLTPLHLAAQEDRVNVAEVL 716
Score = 73.9 bits (180), Expect = 6e-14
Identities = 51/159 (32%), Positives = 77/159 (48%), Gaps = 2/159 (1%)
Query: 9 GDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQGASP 67
G+ AAR EV R L ++ +A + +T L + G I +LL+QGASP
Sbjct: 466 GETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASP 525
Query: 68 NVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLA 127
N TSG +P+H +AR G D L++HGA +++ G P+H+A + G V + L
Sbjct: 526 NAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLL 585
Query: 128 AES-DLHRRDARGLTPLELALQRGAQDLVDILQGHMVAP 165
+S GLTPL +A Q + +L +P
Sbjct: 586 QKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASP 624
Score = 67.4 bits (163), Expect = 5e-12
Identities = 40/110 (36%), Positives = 59/110 (53%), Gaps = 5/110 (4%)
Query: 52 GSTAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPI 111
G + ELL++ A+ + G + +H A+ G + +KVLV +GA+VN G P+
Sbjct: 85 GHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPL 144
Query: 112 HLAVQEGHTAVVSFL---AAESDLHRRDARGLTPLELALQRGAQDLVDIL 158
++A QE H VV FL A L D G TPL +ALQ+G +V +L
Sbjct: 145 YMAAQENHLEVVKFLLDNGASQSLATED--GFTPLAVALQQGHDQVVSLL 192
Score = 62.4 bits (150), Expect = 2e-10
Identities = 44/145 (30%), Positives = 73/145 (50%), Gaps = 2/145 (1%)
Query: 16 AARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMF-GSTAIALELLKQGASPNVQDTSG 74
A +GD +LL + V D + TAL V G +A LL + A+PN + +G
Sbjct: 341 ATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNG 400
Query: 75 TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAE-SDLH 133
+P+H A + + +++L++HGA + +G PIH+A GH +VS L + +
Sbjct: 401 FTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPN 460
Query: 134 RRDARGLTPLELALQRGAQDLVDIL 158
+ RG T L +A + G ++V L
Sbjct: 461 TTNVRGETALHMAARSGQAEVVRYL 485
Score = 60.5 bits (145), Expect = 7e-10
Identities = 41/150 (27%), Positives = 74/150 (49%), Gaps = 2/150 (1%)
Query: 16 AARGDVQEVRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQGASPNVQDTSG 74
AAR D + LL + + D ++ G T L + +G+ +A LL + A+ + +
Sbjct: 209 AARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARND 268
Query: 75 TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLA-AESDLH 133
+P+H A++ G + +K+L++ GA ++ G P+H + GH VV L + +
Sbjct: 269 ITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPIL 328
Query: 134 RRDARGLTPLELALQRGAQDLVDILQGHMV 163
+ GL+PL +A Q + V +L H V
Sbjct: 329 SKTKNGLSPLHMATQGDHLNCVQLLLQHNV 358
Score = 59.3 bits (142), Expect = 1e-09
Identities = 41/145 (28%), Positives = 70/145 (48%), Gaps = 2/145 (1%)
Query: 23 EVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALELL-KQGASPNVQDTSGTSPVHDA 81
+V ++L + +P+A G T L + + +ELL K GAS SG +P+H A
Sbjct: 381 KVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVA 440
Query: 82 ARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAE-SDLHRRDARGL 140
A G ++ + L+ HGA N + G +H+A + G VV +L + + + +
Sbjct: 441 AFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQ 500
Query: 141 TPLELALQRGAQDLVDILQGHMVAP 165
TPL ++ + G D+V L +P
Sbjct: 501 TPLHISARLGKADIVQQLLQQGASP 525
Score = 58.9 bits (141), Expect = 2e-09
Identities = 44/147 (29%), Positives = 68/147 (46%), Gaps = 3/147 (2%)
Query: 15 AAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTA-IALELLKQGASPNVQDTS 73
AA G V V LL R + + N+ G T L + +A L+ QGA + Q
Sbjct: 671 AAQEGHVDMVSLLLGRN-ANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKM 729
Query: 74 GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVS-FLAAESDL 132
G +P+H G + + L++H A VN G P+H A Q+GHT +++ L +
Sbjct: 730 GYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASP 789
Query: 133 HRRDARGLTPLELALQRGAQDLVDILQ 159
+ G T L +A + G +VD L+
Sbjct: 790 NELTVNGNTALGIARRLGYISVVDTLK 816
Score = 50.8 bits (120), Expect = 5e-07
Identities = 40/149 (26%), Positives = 71/149 (47%), Gaps = 3/149 (2%)
Query: 15 AAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALELLKQGASPNVQDT-S 73
A+ RG+ V+ LL R DA R G T L +E+L A+P + T +
Sbjct: 275 ASKRGNANMVKLLLDRG-AKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKN 333
Query: 74 GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVS-FLAAESDL 132
G SP+H A + L+ +++L++H V+ +H+A GH V L +++
Sbjct: 334 GLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANP 393
Query: 133 HRRDARGLTPLELALQRGAQDLVDILQGH 161
+ + G TPL +A ++ ++++L H
Sbjct: 394 NAKALNGFTPLHIACKKNRIKVMELLLKH 422
Score = 48.1 bits (113), Expect = 3e-06
Identities = 27/79 (34%), Positives = 44/79 (55%), Gaps = 1/79 (1%)
Query: 81 AARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVS-FLAAESDLHRRDARG 139
AAR G L+ +++G D+N+ + G +HLA +EGH VVS L E+++ +G
Sbjct: 48 AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG 107
Query: 140 LTPLELALQRGAQDLVDIL 158
T L +A G ++V +L
Sbjct: 108 NTALHIASLAGQAEVVKVL 126
Score = 37.4 bits (85), Expect = 0.006
Identities = 25/84 (29%), Positives = 44/84 (52%), Gaps = 5/84 (5%)
Query: 78 VHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFL---AAESDLHR 134
+H AAR +L+++ + +V +G P+H+A G+ V + L AA D
Sbjct: 206 LHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTA 265
Query: 135 RDARGLTPLELALQRGAQDLVDIL 158
R+ +TPL +A +RG ++V +L
Sbjct: 266 RN--DITPLHVASKRGNANMVKLL 287
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 84.0 bits (206), Expect = 6e-17
Identities = 51/148 (34%), Positives = 81/148 (54%), Gaps = 2/148 (1%)
Query: 16 AARGDVQEVRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQGASPNVQDTSG 74
AA+ +V +LL + D+ + G T L V + + +AL LL++GASP+ +G
Sbjct: 549 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 608
Query: 75 TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAE-SDLH 133
+P+H AA+ + L+ +GA+ N+ G P+HLA QEGHT +V+ L + +++H
Sbjct: 609 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIH 668
Query: 134 RRDARGLTPLELALQRGAQDLVDILQGH 161
GLT L LA Q ++ DIL H
Sbjct: 669 MSTKSGLTSLHLAAQEDKVNVADILTKH 696
Score = 65.9 bits (159), Expect = 2e-11
Identities = 48/147 (32%), Positives = 77/147 (52%), Gaps = 5/147 (3%)
Query: 15 AAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMF-GSTAIALELLKQGASPNVQDTS 73
AA G++ +V L + + + N+ G AL + G + ELL +G+S +
Sbjct: 17 AARAGNLDKVVEYL-KGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK 75
Query: 74 GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAESDLH 133
G + +H A+ G + +KVLV+ GA++N G P+++A QE H VV +L E+ +
Sbjct: 76 GNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLL-ENGAN 134
Query: 134 RRDAR--GLTPLELALQRGAQDLVDIL 158
+ A G TPL +ALQ+G V IL
Sbjct: 135 QSTATEDGFTPLAVALQQGHNQAVAIL 161
Score = 62.8 bits (151), Expect = 1e-10
Identities = 54/160 (33%), Positives = 75/160 (46%), Gaps = 13/160 (8%)
Query: 6 VRAGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQG 64
+R L AA G V+ VR LL + DA R +T L + G T I LL+
Sbjct: 441 IRGETALHMAARAGQVEVVRCLLRNGAL-VDARAREEQTPLHIASRLGKTEIVQLLLQHM 499
Query: 65 ASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVS 124
A P+ T+G +P+H +AR G +D VL+E GA ++ G P+H+A + G V
Sbjct: 500 AHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAK 559
Query: 125 FLAAESDLHRRDA------RGLTPLELALQRGAQDLVDIL 158
L L RR A GLTPL +A Q + +L
Sbjct: 560 LL-----LQRRAAADSAGKNGLTPLHVAAHYDNQKVALLL 594
Score = 62.4 bits (150), Expect = 2e-10
Identities = 47/144 (32%), Positives = 72/144 (50%), Gaps = 2/144 (1%)
Query: 24 VRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALELL-KQGASPNVQDTSGTSPVHDAA 82
V +LL + +P+A G T L + + +ELL K GAS SG +P+H AA
Sbjct: 359 VTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAA 418
Query: 83 RTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAESDLHRRDARG-LT 141
G L+ + +L+++GA +V + G +H+A + G VV L L AR T
Sbjct: 419 FMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQT 478
Query: 142 PLELALQRGAQDLVDILQGHMVAP 165
PL +A + G ++V +L HM P
Sbjct: 479 PLHIASRLGKTEIVQLLLQHMAHP 502
Score = 61.6 bits (148), Expect = 3e-10
Identities = 42/138 (30%), Positives = 68/138 (49%), Gaps = 2/138 (1%)
Query: 23 EVRRLLHRELVHPDALNRFGKTALQVMMF-GSTAIALELLKQGASPNVQDTSGTSPVHDA 81
+V LL + A+ G T + V F G I L LL+ GASP+V + G + +H A
Sbjct: 391 KVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMA 450
Query: 82 ARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAE-SDLHRRDARGL 140
AR G ++ ++ L+ +GA V+ P+H+A + G T +V L + G
Sbjct: 451 ARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGY 510
Query: 141 TPLELALQRGAQDLVDIL 158
TPL ++ + G D+ +L
Sbjct: 511 TPLHISAREGQVDVASVL 528
Score = 60.1 bits (144), Expect = 9e-10
Identities = 34/112 (30%), Positives = 58/112 (51%), Gaps = 1/112 (0%)
Query: 51 FGSTAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALP 110
+G+ +A LL +GA+ + +G +P+H A++ G + +K+L++ G ++ G P
Sbjct: 222 YGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTP 281
Query: 111 IHLAVQEGHTAVVSFLAAE-SDLHRRDARGLTPLELALQRGAQDLVDILQGH 161
+H A + GH VV L + L R GL+PL +A Q + V L H
Sbjct: 282 LHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH 333
Score = 58.5 bits (140), Expect = 2e-09
Identities = 37/112 (33%), Positives = 58/112 (51%), Gaps = 1/112 (0%)
Query: 16 AARGDVQEVRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQGASPNVQDTSG 74
AA+ D V +L + DA + G T L V +G+ + LLKQGA+ N + +G
Sbjct: 681 AAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNG 740
Query: 75 TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFL 126
+P+H AA+ G + VL++HGA N G + +A + G+ +VV L
Sbjct: 741 YTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 792
Score = 57.8 bits (138), Expect = 4e-09
Identities = 33/115 (28%), Positives = 62/115 (53%), Gaps = 1/115 (0%)
Query: 52 GSTAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPI 111
G T + LL +GA+ ++ SG + +H AA+ ++ +L +HGAD + G P+
Sbjct: 652 GHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPL 711
Query: 112 HLAVQEGHTAVVSFLAAE-SDLHRRDARGLTPLELALQRGAQDLVDILQGHMVAP 165
+A G+ +V+FL + ++++ + G TPL A Q+G ++++L H P
Sbjct: 712 IVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKP 766
Score = 56.2 bits (134), Expect = 1e-08
Identities = 46/148 (31%), Positives = 75/148 (50%), Gaps = 8/148 (5%)
Query: 16 AARGD-VQEVRRLLHRELVHPDALNRFGKTALQVMMF-GSTAIALELLKQGASPNVQDTS 73
AA+GD V+ V+ LL + D + TAL V G + LL + A+PN + +
Sbjct: 318 AAQGDHVECVKHLLQHKAPVDDVTLDY-LTALHVAAHCGHYRVTKLLLDKRANPNARALN 376
Query: 74 GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFL---AAES 130
G +P+H A + + +++LV++GA + +G PIH+A GH +V L A
Sbjct: 377 GFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP 436
Query: 131 DLHRRDARGLTPLELALQRGAQDLVDIL 158
D+ + RG T L +A + G ++V L
Sbjct: 437 DV--TNIRGETALHMAARAGQVEVVRCL 462
Score = 50.8 bits (120), Expect = 5e-07
Identities = 31/89 (34%), Positives = 48/89 (53%), Gaps = 5/89 (5%)
Query: 73 SGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFL---AAE 129
SG +P+H AA G ++ +L+ GA V+ G P+H+A + G+T +V L +
Sbjct: 211 SGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQ 270
Query: 130 SDLHRRDARGLTPLELALQRGAQDLVDIL 158
D RD GLTPL A + G +V++L
Sbjct: 271 IDAKTRD--GLTPLHCAARSGHDQVVELL 297
Score = 49.7 bits (117), Expect = 1e-06
Identities = 42/146 (28%), Positives = 70/146 (47%), Gaps = 3/146 (2%)
Query: 15 AAARGDVQEVRRLLHRELVHPDALNRFGKTALQ-VMMFGSTAIALELLKQGASPNVQDTS 73
A+ RG+ V+ LL R DA R G T L G + LL++GA + +
Sbjct: 252 ASKRGNTNMVKLLLDRG-GQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKN 310
Query: 74 GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLA-AESDL 132
G SP+H AA+ ++ +K L++H A V+ +H+A GH V L ++
Sbjct: 311 GLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP 370
Query: 133 HRRDARGLTPLELALQRGAQDLVDIL 158
+ R G TPL +A ++ ++++L
Sbjct: 371 NARALNGFTPLHIACKKNRIKVMELL 396
Score = 36.6 bits (83), Expect = 0.010
Identities = 38/117 (32%), Positives = 54/117 (46%), Gaps = 8/117 (6%)
Query: 19 GDVQEVRRLLHRELVHPDALNRFGKTAL-QVMMFGSTAIALELLKQGASPNVQDTSGTSP 77
G+V+ V LL ++ + +A + G T L Q G T I LL+ GA PN +G +
Sbjct: 718 GNVKMVNFLL-KQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTA 776
Query: 78 VHDAARTGFL---DTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAESD 131
+ A R G++ DTLKV+ E +V T L V E T V+ E D
Sbjct: 777 LAIAKRLGYISVVDTLKVVTE---EVTTTTTTITEKHKLNVPETMTEVLDVSDEEGD 830
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 84.0 bits (206), Expect = 6e-17
Identities = 51/148 (34%), Positives = 81/148 (54%), Gaps = 2/148 (1%)
Query: 16 AARGDVQEVRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQGASPNVQDTSG 74
AA+ +V +LL + D+ + G T L V + + +AL LL++GASP+ +G
Sbjct: 570 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 629
Query: 75 TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAE-SDLH 133
+P+H AA+ + L+ +GA+ N+ G P+HLA QEGHT +V+ L + +++H
Sbjct: 630 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIH 689
Query: 134 RRDARGLTPLELALQRGAQDLVDILQGH 161
GLT L LA Q ++ DIL H
Sbjct: 690 MSTKSGLTSLHLAAQEDKVNVADILTKH 717
Score = 65.9 bits (159), Expect = 2e-11
Identities = 48/147 (32%), Positives = 77/147 (52%), Gaps = 5/147 (3%)
Query: 15 AAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMF-GSTAIALELLKQGASPNVQDTS 73
AA G++ +V L + + + N+ G AL + G + ELL +G+S +
Sbjct: 38 AARAGNLDKVVEYL-KGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK 96
Query: 74 GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAESDLH 133
G + +H A+ G + +KVLV+ GA++N G P+++A QE H VV +L E+ +
Sbjct: 97 GNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLL-ENGAN 155
Query: 134 RRDAR--GLTPLELALQRGAQDLVDIL 158
+ A G TPL +ALQ+G V IL
Sbjct: 156 QSTATEDGFTPLAVALQQGHNQAVAIL 182
Score = 62.8 bits (151), Expect = 1e-10
Identities = 54/160 (33%), Positives = 75/160 (46%), Gaps = 13/160 (8%)
Query: 6 VRAGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQG 64
+R L AA G V+ VR LL + DA R +T L + G T I LL+
Sbjct: 462 IRGETALHMAARAGQVEVVRCLLRNGAL-VDARAREEQTPLHIASRLGKTEIVQLLLQHM 520
Query: 65 ASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVS 124
A P+ T+G +P+H +AR G +D VL+E GA ++ G P+H+A + G V
Sbjct: 521 AHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAK 580
Query: 125 FLAAESDLHRRDA------RGLTPLELALQRGAQDLVDIL 158
L L RR A GLTPL +A Q + +L
Sbjct: 581 LL-----LQRRAAADSAGKNGLTPLHVAAHYDNQKVALLL 615
Score = 62.4 bits (150), Expect = 2e-10
Identities = 47/144 (32%), Positives = 72/144 (50%), Gaps = 2/144 (1%)
Query: 24 VRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALELL-KQGASPNVQDTSGTSPVHDAA 82
V +LL + +P+A G T L + + +ELL K GAS SG +P+H AA
Sbjct: 380 VTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAA 439
Query: 83 RTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAESDLHRRDARG-LT 141
G L+ + +L+++GA +V + G +H+A + G VV L L AR T
Sbjct: 440 FMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQT 499
Query: 142 PLELALQRGAQDLVDILQGHMVAP 165
PL +A + G ++V +L HM P
Sbjct: 500 PLHIASRLGKTEIVQLLLQHMAHP 523
Score = 61.6 bits (148), Expect = 3e-10
Identities = 42/138 (30%), Positives = 68/138 (49%), Gaps = 2/138 (1%)
Query: 23 EVRRLLHRELVHPDALNRFGKTALQVMMF-GSTAIALELLKQGASPNVQDTSGTSPVHDA 81
+V LL + A+ G T + V F G I L LL+ GASP+V + G + +H A
Sbjct: 412 KVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMA 471
Query: 82 ARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAE-SDLHRRDARGL 140
AR G ++ ++ L+ +GA V+ P+H+A + G T +V L + G
Sbjct: 472 ARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGY 531
Query: 141 TPLELALQRGAQDLVDIL 158
TPL ++ + G D+ +L
Sbjct: 532 TPLHISAREGQVDVASVL 549
Score = 60.1 bits (144), Expect = 9e-10
Identities = 34/112 (30%), Positives = 58/112 (51%), Gaps = 1/112 (0%)
Query: 51 FGSTAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALP 110
+G+ +A LL +GA+ + +G +P+H A++ G + +K+L++ G ++ G P
Sbjct: 243 YGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTP 302
Query: 111 IHLAVQEGHTAVVSFLAAE-SDLHRRDARGLTPLELALQRGAQDLVDILQGH 161
+H A + GH VV L + L R GL+PL +A Q + V L H
Sbjct: 303 LHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH 354
Score = 58.5 bits (140), Expect = 2e-09
Identities = 37/112 (33%), Positives = 58/112 (51%), Gaps = 1/112 (0%)
Query: 16 AARGDVQEVRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQGASPNVQDTSG 74
AA+ D V +L + DA + G T L V +G+ + LLKQGA+ N + +G
Sbjct: 702 AAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNG 761
Query: 75 TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFL 126
+P+H AA+ G + VL++HGA N G + +A + G+ +VV L
Sbjct: 762 YTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813
Score = 57.8 bits (138), Expect = 4e-09
Identities = 33/115 (28%), Positives = 62/115 (53%), Gaps = 1/115 (0%)
Query: 52 GSTAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPI 111
G T + LL +GA+ ++ SG + +H AA+ ++ +L +HGAD + G P+
Sbjct: 673 GHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPL 732
Query: 112 HLAVQEGHTAVVSFLAAE-SDLHRRDARGLTPLELALQRGAQDLVDILQGHMVAP 165
+A G+ +V+FL + ++++ + G TPL A Q+G ++++L H P
Sbjct: 733 IVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKP 787
Score = 56.2 bits (134), Expect = 1e-08
Identities = 46/148 (31%), Positives = 75/148 (50%), Gaps = 8/148 (5%)
Query: 16 AARGD-VQEVRRLLHRELVHPDALNRFGKTALQVMMF-GSTAIALELLKQGASPNVQDTS 73
AA+GD V+ V+ LL + D + TAL V G + LL + A+PN + +
Sbjct: 339 AAQGDHVECVKHLLQHKAPVDDVTLDY-LTALHVAAHCGHYRVTKLLLDKRANPNARALN 397
Query: 74 GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFL---AAES 130
G +P+H A + + +++LV++GA + +G PIH+A GH +V L A
Sbjct: 398 GFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP 457
Query: 131 DLHRRDARGLTPLELALQRGAQDLVDIL 158
D+ + RG T L +A + G ++V L
Sbjct: 458 DV--TNIRGETALHMAARAGQVEVVRCL 483
Score = 50.8 bits (120), Expect = 5e-07
Identities = 31/89 (34%), Positives = 48/89 (53%), Gaps = 5/89 (5%)
Query: 73 SGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFL---AAE 129
SG +P+H AA G ++ +L+ GA V+ G P+H+A + G+T +V L +
Sbjct: 232 SGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQ 291
Query: 130 SDLHRRDARGLTPLELALQRGAQDLVDIL 158
D RD GLTPL A + G +V++L
Sbjct: 292 IDAKTRD--GLTPLHCAARSGHDQVVELL 318
Score = 49.7 bits (117), Expect = 1e-06
Identities = 42/146 (28%), Positives = 70/146 (47%), Gaps = 3/146 (2%)
Query: 15 AAARGDVQEVRRLLHRELVHPDALNRFGKTALQ-VMMFGSTAIALELLKQGASPNVQDTS 73
A+ RG+ V+ LL R DA R G T L G + LL++GA + +
Sbjct: 273 ASKRGNTNMVKLLLDRG-GQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKN 331
Query: 74 GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLA-AESDL 132
G SP+H AA+ ++ +K L++H A V+ +H+A GH V L ++
Sbjct: 332 GLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP 391
Query: 133 HRRDARGLTPLELALQRGAQDLVDIL 158
+ R G TPL +A ++ ++++L
Sbjct: 392 NARALNGFTPLHIACKKNRIKVMELL 417
Score = 36.6 bits (83), Expect = 0.010
Identities = 38/117 (32%), Positives = 54/117 (46%), Gaps = 8/117 (6%)
Query: 19 GDVQEVRRLLHRELVHPDALNRFGKTAL-QVMMFGSTAIALELLKQGASPNVQDTSGTSP 77
G+V+ V LL ++ + +A + G T L Q G T I LL+ GA PN +G +
Sbjct: 739 GNVKMVNFLL-KQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTA 797
Query: 78 VHDAARTGFL---DTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAESD 131
+ A R G++ DTLKV+ E +V T L V E T V+ E D
Sbjct: 798 LAIAKRLGYISVVDTLKVVTE---EVTTTTTTITEKHKLNVPETMTEVLDVSDEEGD 851
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 84.0 bits (206), Expect = 6e-17
Identities = 51/148 (34%), Positives = 81/148 (54%), Gaps = 2/148 (1%)
Query: 16 AARGDVQEVRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQGASPNVQDTSG 74
AA+ +V +LL + D+ + G T L V + + +AL LL++GASP+ +G
Sbjct: 570 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 629
Query: 75 TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAE-SDLH 133
+P+H AA+ + L+ +GA+ N+ G P+HLA QEGHT +V+ L + +++H
Sbjct: 630 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIH 689
Query: 134 RRDARGLTPLELALQRGAQDLVDILQGH 161
GLT L LA Q ++ DIL H
Sbjct: 690 MSTKSGLTSLHLAAQEDKVNVADILTKH 717
Score = 65.9 bits (159), Expect = 2e-11
Identities = 48/147 (32%), Positives = 77/147 (52%), Gaps = 5/147 (3%)
Query: 15 AAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMF-GSTAIALELLKQGASPNVQDTS 73
AA G++ +V L + + + N+ G AL + G + ELL +G+S +
Sbjct: 38 AARAGNLDKVVEYL-KGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK 96
Query: 74 GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAESDLH 133
G + +H A+ G + +KVLV+ GA++N G P+++A QE H VV +L E+ +
Sbjct: 97 GNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLL-ENGAN 155
Query: 134 RRDAR--GLTPLELALQRGAQDLVDIL 158
+ A G TPL +ALQ+G V IL
Sbjct: 156 QSTATEDGFTPLAVALQQGHNQAVAIL 182
Score = 62.8 bits (151), Expect = 1e-10
Identities = 54/160 (33%), Positives = 75/160 (46%), Gaps = 13/160 (8%)
Query: 6 VRAGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQG 64
+R L AA G V+ VR LL + DA R +T L + G T I LL+
Sbjct: 462 IRGETALHMAARAGQVEVVRCLLRNGAL-VDARAREEQTPLHIASRLGKTEIVQLLLQHM 520
Query: 65 ASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVS 124
A P+ T+G +P+H +AR G +D VL+E GA ++ G P+H+A + G V
Sbjct: 521 AHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAK 580
Query: 125 FLAAESDLHRRDA------RGLTPLELALQRGAQDLVDIL 158
L L RR A GLTPL +A Q + +L
Sbjct: 581 LL-----LQRRAAADSAGKNGLTPLHVAAHYDNQKVALLL 615
Score = 62.4 bits (150), Expect = 2e-10
Identities = 47/144 (32%), Positives = 72/144 (50%), Gaps = 2/144 (1%)
Query: 24 VRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALELL-KQGASPNVQDTSGTSPVHDAA 82
V +LL + +P+A G T L + + +ELL K GAS SG +P+H AA
Sbjct: 380 VTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAA 439
Query: 83 RTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAESDLHRRDARG-LT 141
G L+ + +L+++GA +V + G +H+A + G VV L L AR T
Sbjct: 440 FMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQT 499
Query: 142 PLELALQRGAQDLVDILQGHMVAP 165
PL +A + G ++V +L HM P
Sbjct: 500 PLHIASRLGKTEIVQLLLQHMAHP 523
Score = 61.6 bits (148), Expect = 3e-10
Identities = 42/138 (30%), Positives = 68/138 (49%), Gaps = 2/138 (1%)
Query: 23 EVRRLLHRELVHPDALNRFGKTALQVMMF-GSTAIALELLKQGASPNVQDTSGTSPVHDA 81
+V LL + A+ G T + V F G I L LL+ GASP+V + G + +H A
Sbjct: 412 KVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMA 471
Query: 82 ARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAE-SDLHRRDARGL 140
AR G ++ ++ L+ +GA V+ P+H+A + G T +V L + G
Sbjct: 472 ARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGY 531
Query: 141 TPLELALQRGAQDLVDIL 158
TPL ++ + G D+ +L
Sbjct: 532 TPLHISAREGQVDVASVL 549
Score = 60.1 bits (144), Expect = 9e-10
Identities = 34/112 (30%), Positives = 58/112 (51%), Gaps = 1/112 (0%)
Query: 51 FGSTAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALP 110
+G+ +A LL +GA+ + +G +P+H A++ G + +K+L++ G ++ G P
Sbjct: 243 YGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTP 302
Query: 111 IHLAVQEGHTAVVSFLAAE-SDLHRRDARGLTPLELALQRGAQDLVDILQGH 161
+H A + GH VV L + L R GL+PL +A Q + V L H
Sbjct: 303 LHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH 354
Score = 58.5 bits (140), Expect = 2e-09
Identities = 37/112 (33%), Positives = 58/112 (51%), Gaps = 1/112 (0%)
Query: 16 AARGDVQEVRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQGASPNVQDTSG 74
AA+ D V +L + DA + G T L V +G+ + LLKQGA+ N + +G
Sbjct: 702 AAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNG 761
Query: 75 TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFL 126
+P+H AA+ G + VL++HGA N G + +A + G+ +VV L
Sbjct: 762 YTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813
Score = 57.8 bits (138), Expect = 4e-09
Identities = 33/115 (28%), Positives = 62/115 (53%), Gaps = 1/115 (0%)
Query: 52 GSTAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPI 111
G T + LL +GA+ ++ SG + +H AA+ ++ +L +HGAD + G P+
Sbjct: 673 GHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPL 732
Query: 112 HLAVQEGHTAVVSFLAAE-SDLHRRDARGLTPLELALQRGAQDLVDILQGHMVAP 165
+A G+ +V+FL + ++++ + G TPL A Q+G ++++L H P
Sbjct: 733 IVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKP 787
Score = 56.2 bits (134), Expect = 1e-08
Identities = 46/148 (31%), Positives = 75/148 (50%), Gaps = 8/148 (5%)
Query: 16 AARGD-VQEVRRLLHRELVHPDALNRFGKTALQVMMF-GSTAIALELLKQGASPNVQDTS 73
AA+GD V+ V+ LL + D + TAL V G + LL + A+PN + +
Sbjct: 339 AAQGDHVECVKHLLQHKAPVDDVTLDY-LTALHVAAHCGHYRVTKLLLDKRANPNARALN 397
Query: 74 GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFL---AAES 130
G +P+H A + + +++LV++GA + +G PIH+A GH +V L A
Sbjct: 398 GFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP 457
Query: 131 DLHRRDARGLTPLELALQRGAQDLVDIL 158
D+ + RG T L +A + G ++V L
Sbjct: 458 DV--TNIRGETALHMAARAGQVEVVRCL 483
Score = 50.8 bits (120), Expect = 5e-07
Identities = 31/89 (34%), Positives = 48/89 (53%), Gaps = 5/89 (5%)
Query: 73 SGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFL---AAE 129
SG +P+H AA G ++ +L+ GA V+ G P+H+A + G+T +V L +
Sbjct: 232 SGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQ 291
Query: 130 SDLHRRDARGLTPLELALQRGAQDLVDIL 158
D RD GLTPL A + G +V++L
Sbjct: 292 IDAKTRD--GLTPLHCAARSGHDQVVELL 318
Score = 49.7 bits (117), Expect = 1e-06
Identities = 42/146 (28%), Positives = 70/146 (47%), Gaps = 3/146 (2%)
Query: 15 AAARGDVQEVRRLLHRELVHPDALNRFGKTALQ-VMMFGSTAIALELLKQGASPNVQDTS 73
A+ RG+ V+ LL R DA R G T L G + LL++GA + +
Sbjct: 273 ASKRGNTNMVKLLLDRG-GQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKN 331
Query: 74 GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLA-AESDL 132
G SP+H AA+ ++ +K L++H A V+ +H+A GH V L ++
Sbjct: 332 GLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP 391
Query: 133 HRRDARGLTPLELALQRGAQDLVDIL 158
+ R G TPL +A ++ ++++L
Sbjct: 392 NARALNGFTPLHIACKKNRIKVMELL 417
Score = 36.6 bits (83), Expect = 0.010
Identities = 38/117 (32%), Positives = 54/117 (46%), Gaps = 8/117 (6%)
Query: 19 GDVQEVRRLLHRELVHPDALNRFGKTAL-QVMMFGSTAIALELLKQGASPNVQDTSGTSP 77
G+V+ V LL ++ + +A + G T L Q G T I LL+ GA PN +G +
Sbjct: 739 GNVKMVNFLL-KQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTA 797
Query: 78 VHDAARTGFL---DTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAESD 131
+ A R G++ DTLKV+ E +V T L V E T V+ E D
Sbjct: 798 LAIAKRLGYISVVDTLKVVTE---EVTTTTTTITEKHKLNVPETMTEVLDVSDEEGD 851
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 79.3 bits (194), Expect = 1e-15
Identities = 51/151 (33%), Positives = 80/151 (52%), Gaps = 3/151 (1%)
Query: 15 AAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTA-IALELLKQGASPNVQDTS 73
AA G V+ LL R+ HP+A + G T L V + + I LL +G SP+ +
Sbjct: 576 AAKYGKVRVAELLLERD-AHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWN 634
Query: 74 GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVS-FLAAESDL 132
G +P+H AA+ ++ + L+++G N G P+HLA QEGH +V+ L+ +++
Sbjct: 635 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 694
Query: 133 HRRDARGLTPLELALQRGAQDLVDILQGHMV 163
+ + GLTPL L Q G + D+L H V
Sbjct: 695 NLGNKSGLTPLHLVAQEGHVPVADVLIKHGV 725
Score = 69.7 bits (169), Expect = 1e-12
Identities = 40/113 (35%), Positives = 66/113 (58%), Gaps = 2/113 (1%)
Query: 15 AAARGDVQEVRRLLHRELVHPDALNRFGKTALQVM-MFGSTAIALELLKQGASPNVQDTS 73
A+ G V+ V LLH+E++ + + G TAL + + G + EL+ GA+ N Q
Sbjct: 85 ASKEGHVKMVVELLHKEIIL-ETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK 143
Query: 74 GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFL 126
G +P++ AA+ L+ +K L+E+GA+ NV G P+ +A+Q+GH VV+ L
Sbjct: 144 GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHL 196
Score = 68.6 bits (166), Expect = 2e-12
Identities = 49/158 (31%), Positives = 78/158 (49%), Gaps = 3/158 (1%)
Query: 4 EEVRAGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQ-VMMFGSTAIALELLK 62
E V+ L AA G + V LL ++ + + N+ G T L V G +A L+K
Sbjct: 664 ESVQGVTPLHLAAQEGHAEMVALLLSKQ-ANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 722
Query: 63 QGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAV 122
G + G +P+H A+ G + +K L++H ADVN G P+H A Q+GHT +
Sbjct: 723 HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI 782
Query: 123 VSFLAAE-SDLHRRDARGLTPLELALQRGAQDLVDILQ 159
V+ L + + + G TPL +A + G + D+L+
Sbjct: 783 VTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK 820
Score = 67.8 bits (164), Expect = 4e-12
Identities = 46/134 (34%), Positives = 66/134 (49%), Gaps = 2/134 (1%)
Query: 24 VRRLLHRELVHPDALNRFGKTALQVMMF-GSTAIALELLKQGASPNVQDTSGTSPVHDAA 82
V LL + DA+ G T L V F G I LL++GASPNV + +P+H AA
Sbjct: 419 VMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAA 478
Query: 83 RTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAA-ESDLHRRDARGLT 141
R G + K L+++ A VN P+H A + GHT +V L ++ + G T
Sbjct: 479 RAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHT 538
Query: 142 PLELALQRGAQDLV 155
PL +A + G + V
Sbjct: 539 PLHIAAREGHVETV 552
Score = 65.5 bits (158), Expect = 2e-11
Identities = 41/145 (28%), Positives = 72/145 (49%), Gaps = 2/145 (1%)
Query: 16 AARGDVQEVRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQGASPNVQDTSG 74
AAR D +L + +PD L++ G T L + + + +A LL +GAS N +G
Sbjct: 213 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 272
Query: 75 TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAE-SDLH 133
+P+H A+R G + +++L++ GA + P+H A + GH + L + +
Sbjct: 273 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 332
Query: 134 RRDARGLTPLELALQRGAQDLVDIL 158
+ GL+P+ +A Q D V +L
Sbjct: 333 AKTKNGLSPIHMAAQGDHLDCVRLL 357
Score = 65.5 bits (158), Expect = 2e-11
Identities = 48/146 (32%), Positives = 71/146 (48%), Gaps = 4/146 (2%)
Query: 16 AARGDVQEVRRLLHRELVHPDALNRFGKTALQ-VMMFGSTAIALELLKQGASPNVQDTSG 74
AAR EV + L + +A + +T L G T + LL+ A+PN+ T+G
Sbjct: 477 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG 536
Query: 75 TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAESDLHR 134
+P+H AAR G ++T+ L+E A G P+H+A + G V L E D H
Sbjct: 537 HTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELL-LERDAHP 595
Query: 135 RDA--RGLTPLELALQRGAQDLVDIL 158
A GLTPL +A+ D+V +L
Sbjct: 596 NAAGKNGLTPLHVAVHHNNLDIVKLL 621
Score = 62.4 bits (150), Expect = 2e-10
Identities = 45/152 (29%), Positives = 78/152 (51%), Gaps = 2/152 (1%)
Query: 16 AARGDVQEVRRLLHRELVHPDALNRFGKTALQVM-MFGSTAIALELLKQGASPNVQDTSG 74
AA+ + EV R L + +A + G T L + G + LL + A+ N+ + SG
Sbjct: 642 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 701
Query: 75 TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAA-ESDLH 133
+P+H A+ G + VL++HG V+ G P+H+A G+ +V FL ++D++
Sbjct: 702 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 761
Query: 134 RRDARGLTPLELALQRGAQDLVDILQGHMVAP 165
+ G +PL A Q+G D+V +L + +P
Sbjct: 762 AKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP 793
Score = 54.7 bits (130), Expect = 4e-08
Identities = 40/145 (27%), Positives = 72/145 (49%), Gaps = 2/145 (1%)
Query: 16 AARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMF-GSTAIALELLKQGASPNVQDTSG 74
AA+GD + RLL + D + T L V G +A LL +GA PN + +G
Sbjct: 345 AAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG 404
Query: 75 TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVV-SFLAAESDLH 133
+P+H A + + +++L++ GA ++ +G P+H+A GH +V + L + +
Sbjct: 405 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 464
Query: 134 RRDARGLTPLELALQRGAQDLVDIL 158
+ + TPL +A + G ++ L
Sbjct: 465 VSNVKVETPLHMAARAGHTEVAKYL 489
Score = 52.8 bits (125), Expect = 1e-07
Identities = 34/109 (31%), Positives = 54/109 (49%), Gaps = 1/109 (0%)
Query: 24 VRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQGASPNVQDTSGTSPVHDAA 82
V +L + V DA R G T L V +G+ + LL+ A N + G SP+H AA
Sbjct: 716 VADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAA 775
Query: 83 RTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAESD 131
+ G D + +L+++GA N G P+ +A + G+ +V L +D
Sbjct: 776 QQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTD 824
Score = 41.2 bits (95), Expect = 4e-04
Identities = 27/76 (35%), Positives = 38/76 (50%), Gaps = 1/76 (1%)
Query: 81 AARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHT-AVVSFLAAESDLHRRDARG 139
AAR+G LD + +G D+N + G +HLA +EGH VV L E L +G
Sbjct: 52 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 111
Query: 140 LTPLELALQRGAQDLV 155
T L +A G ++V
Sbjct: 112 NTALHIAALAGQDEVV 127
Score = 38.5 bits (88), Expect = 0.003
Identities = 37/145 (25%), Positives = 63/145 (43%), Gaps = 6/145 (4%)
Query: 16 AARGDVQEVRRLLHRELVHPDALNRFGKTALQV-MMFGSTAIALELLKQGASPNVQDTSG 74
AA+ + EV + L + + G T L V + G + L+ G V+
Sbjct: 151 AAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR---- 206
Query: 75 TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAE-SDLH 133
+H AAR T VL+++ + +V TG P+H+A + V L + ++
Sbjct: 207 LPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN 266
Query: 134 RRDARGLTPLELALQRGAQDLVDIL 158
G+TPL +A +RG +V +L
Sbjct: 267 FTPQNGITPLHIASRRGNVIMVRLL 291
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 79.3 bits (194), Expect = 1e-15
Identities = 51/151 (33%), Positives = 80/151 (52%), Gaps = 3/151 (1%)
Query: 15 AAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTA-IALELLKQGASPNVQDTS 73
AA G V+ LL R+ HP+A + G T L V + + I LL +G SP+ +
Sbjct: 543 AAKYGKVRVAELLLERD-AHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWN 601
Query: 74 GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVS-FLAAESDL 132
G +P+H AA+ ++ + L+++G N G P+HLA QEGH +V+ L+ +++
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661
Query: 133 HRRDARGLTPLELALQRGAQDLVDILQGHMV 163
+ + GLTPL L Q G + D+L H V
Sbjct: 662 NLGNKSGLTPLHLVAQEGHVPVADVLIKHGV 692
Score = 69.7 bits (169), Expect = 1e-12
Identities = 40/113 (35%), Positives = 66/113 (58%), Gaps = 2/113 (1%)
Query: 15 AAARGDVQEVRRLLHRELVHPDALNRFGKTALQVM-MFGSTAIALELLKQGASPNVQDTS 73
A+ G V+ V LLH+E++ + + G TAL + + G + EL+ GA+ N Q
Sbjct: 52 ASKEGHVKMVVELLHKEIIL-ETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK 110
Query: 74 GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFL 126
G +P++ AA+ L+ +K L+E+GA+ NV G P+ +A+Q+GH VV+ L
Sbjct: 111 GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHL 163
Score = 68.6 bits (166), Expect = 2e-12
Identities = 49/158 (31%), Positives = 78/158 (49%), Gaps = 3/158 (1%)
Query: 4 EEVRAGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQ-VMMFGSTAIALELLK 62
E V+ L AA G + V LL ++ + + N+ G T L V G +A L+K
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQ-ANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689
Query: 63 QGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAV 122
G + G +P+H A+ G + +K L++H ADVN G P+H A Q+GHT +
Sbjct: 690 HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI 749
Query: 123 VSFLAAE-SDLHRRDARGLTPLELALQRGAQDLVDILQ 159
V+ L + + + G TPL +A + G + D+L+
Sbjct: 750 VTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK 787
Score = 67.8 bits (164), Expect = 4e-12
Identities = 46/134 (34%), Positives = 66/134 (49%), Gaps = 2/134 (1%)
Query: 24 VRRLLHRELVHPDALNRFGKTALQVMMF-GSTAIALELLKQGASPNVQDTSGTSPVHDAA 82
V LL + DA+ G T L V F G I LL++GASPNV + +P+H AA
Sbjct: 386 VMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAA 445
Query: 83 RTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAA-ESDLHRRDARGLT 141
R G + K L+++ A VN P+H A + GHT +V L ++ + G T
Sbjct: 446 RAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHT 505
Query: 142 PLELALQRGAQDLV 155
PL +A + G + V
Sbjct: 506 PLHIAAREGHVETV 519
Score = 65.5 bits (158), Expect = 2e-11
Identities = 41/145 (28%), Positives = 72/145 (49%), Gaps = 2/145 (1%)
Query: 16 AARGDVQEVRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQGASPNVQDTSG 74
AAR D +L + +PD L++ G T L + + + +A LL +GAS N +G
Sbjct: 180 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239
Query: 75 TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAE-SDLH 133
+P+H A+R G + +++L++ GA + P+H A + GH + L + +
Sbjct: 240 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 299
Query: 134 RRDARGLTPLELALQRGAQDLVDIL 158
+ GL+P+ +A Q D V +L
Sbjct: 300 AKTKNGLSPIHMAAQGDHLDCVRLL 324
Score = 65.5 bits (158), Expect = 2e-11
Identities = 48/146 (32%), Positives = 71/146 (48%), Gaps = 4/146 (2%)
Query: 16 AARGDVQEVRRLLHRELVHPDALNRFGKTALQ-VMMFGSTAIALELLKQGASPNVQDTSG 74
AAR EV + L + +A + +T L G T + LL+ A+PN+ T+G
Sbjct: 444 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG 503
Query: 75 TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAESDLHR 134
+P+H AAR G ++T+ L+E A G P+H+A + G V L E D H
Sbjct: 504 HTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELL-LERDAHP 562
Query: 135 RDA--RGLTPLELALQRGAQDLVDIL 158
A GLTPL +A+ D+V +L
Sbjct: 563 NAAGKNGLTPLHVAVHHNNLDIVKLL 588
Score = 62.4 bits (150), Expect = 2e-10
Identities = 45/152 (29%), Positives = 78/152 (51%), Gaps = 2/152 (1%)
Query: 16 AARGDVQEVRRLLHRELVHPDALNRFGKTALQVM-MFGSTAIALELLKQGASPNVQDTSG 74
AA+ + EV R L + +A + G T L + G + LL + A+ N+ + SG
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 668
Query: 75 TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAA-ESDLH 133
+P+H A+ G + VL++HG V+ G P+H+A G+ +V FL ++D++
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 728
Query: 134 RRDARGLTPLELALQRGAQDLVDILQGHMVAP 165
+ G +PL A Q+G D+V +L + +P
Sbjct: 729 AKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP 760
Score = 54.7 bits (130), Expect = 4e-08
Identities = 40/145 (27%), Positives = 72/145 (49%), Gaps = 2/145 (1%)
Query: 16 AARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMF-GSTAIALELLKQGASPNVQDTSG 74
AA+GD + RLL + D + T L V G +A LL +GA PN + +G
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG 371
Query: 75 TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVV-SFLAAESDLH 133
+P+H A + + +++L++ GA ++ +G P+H+A GH +V + L + +
Sbjct: 372 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431
Query: 134 RRDARGLTPLELALQRGAQDLVDIL 158
+ + TPL +A + G ++ L
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYL 456
Score = 52.8 bits (125), Expect = 1e-07
Identities = 34/109 (31%), Positives = 54/109 (49%), Gaps = 1/109 (0%)
Query: 24 VRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQGASPNVQDTSGTSPVHDAA 82
V +L + V DA R G T L V +G+ + LL+ A N + G SP+H AA
Sbjct: 683 VADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAA 742
Query: 83 RTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAESD 131
+ G D + +L+++GA N G P+ +A + G+ +V L +D
Sbjct: 743 QQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTD 791
Score = 41.2 bits (95), Expect = 4e-04
Identities = 27/76 (35%), Positives = 38/76 (50%), Gaps = 1/76 (1%)
Query: 81 AARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHT-AVVSFLAAESDLHRRDARG 139
AAR+G LD + +G D+N + G +HLA +EGH VV L E L +G
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78
Query: 140 LTPLELALQRGAQDLV 155
T L +A G ++V
Sbjct: 79 NTALHIAALAGQDEVV 94
Score = 38.5 bits (88), Expect = 0.003
Identities = 37/145 (25%), Positives = 63/145 (43%), Gaps = 6/145 (4%)
Query: 16 AARGDVQEVRRLLHRELVHPDALNRFGKTALQV-MMFGSTAIALELLKQGASPNVQDTSG 74
AA+ + EV + L + + G T L V + G + L+ G V+
Sbjct: 118 AAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR---- 173
Query: 75 TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAE-SDLH 133
+H AAR T VL+++ + +V TG P+H+A + V L + ++
Sbjct: 174 LPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN 233
Query: 134 RRDARGLTPLELALQRGAQDLVDIL 158
G+TPL +A +RG +V +L
Sbjct: 234 FTPQNGITPLHIASRRGNVIMVRLL 258
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 79.3 bits (194), Expect = 1e-15
Identities = 51/151 (33%), Positives = 80/151 (52%), Gaps = 3/151 (1%)
Query: 15 AAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTA-IALELLKQGASPNVQDTS 73
AA G V+ LL R+ HP+A + G T L V + + I LL +G SP+ +
Sbjct: 543 AAKYGKVRVAELLLERD-AHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWN 601
Query: 74 GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVS-FLAAESDL 132
G +P+H AA+ ++ + L+++G N G P+HLA QEGH +V+ L+ +++
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661
Query: 133 HRRDARGLTPLELALQRGAQDLVDILQGHMV 163
+ + GLTPL L Q G + D+L H V
Sbjct: 662 NLGNKSGLTPLHLVAQEGHVPVADVLIKHGV 692
Score = 69.7 bits (169), Expect = 1e-12
Identities = 40/113 (35%), Positives = 66/113 (58%), Gaps = 2/113 (1%)
Query: 15 AAARGDVQEVRRLLHRELVHPDALNRFGKTALQVM-MFGSTAIALELLKQGASPNVQDTS 73
A+ G V+ V LLH+E++ + + G TAL + + G + EL+ GA+ N Q
Sbjct: 52 ASKEGHVKMVVELLHKEIIL-ETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK 110
Query: 74 GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFL 126
G +P++ AA+ L+ +K L+E+GA+ NV G P+ +A+Q+GH VV+ L
Sbjct: 111 GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHL 163
Score = 68.6 bits (166), Expect = 2e-12
Identities = 49/158 (31%), Positives = 78/158 (49%), Gaps = 3/158 (1%)
Query: 4 EEVRAGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQ-VMMFGSTAIALELLK 62
E V+ L AA G + V LL ++ + + N+ G T L V G +A L+K
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQ-ANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689
Query: 63 QGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAV 122
G + G +P+H A+ G + +K L++H ADVN G P+H A Q+GHT +
Sbjct: 690 HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI 749
Query: 123 VSFLAAE-SDLHRRDARGLTPLELALQRGAQDLVDILQ 159
V+ L + + + G TPL +A + G + D+L+
Sbjct: 750 VTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK 787
Score = 67.8 bits (164), Expect = 4e-12
Identities = 46/134 (34%), Positives = 66/134 (49%), Gaps = 2/134 (1%)
Query: 24 VRRLLHRELVHPDALNRFGKTALQVMMF-GSTAIALELLKQGASPNVQDTSGTSPVHDAA 82
V LL + DA+ G T L V F G I LL++GASPNV + +P+H AA
Sbjct: 386 VMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAA 445
Query: 83 RTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAA-ESDLHRRDARGLT 141
R G + K L+++ A VN P+H A + GHT +V L ++ + G T
Sbjct: 446 RAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHT 505
Query: 142 PLELALQRGAQDLV 155
PL +A + G + V
Sbjct: 506 PLHIAAREGHVETV 519
Score = 65.5 bits (158), Expect = 2e-11
Identities = 41/145 (28%), Positives = 72/145 (49%), Gaps = 2/145 (1%)
Query: 16 AARGDVQEVRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQGASPNVQDTSG 74
AAR D +L + +PD L++ G T L + + + +A LL +GAS N +G
Sbjct: 180 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239
Query: 75 TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAE-SDLH 133
+P+H A+R G + +++L++ GA + P+H A + GH + L + +
Sbjct: 240 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 299
Query: 134 RRDARGLTPLELALQRGAQDLVDIL 158
+ GL+P+ +A Q D V +L
Sbjct: 300 AKTKNGLSPIHMAAQGDHLDCVRLL 324
Score = 65.5 bits (158), Expect = 2e-11
Identities = 48/146 (32%), Positives = 71/146 (48%), Gaps = 4/146 (2%)
Query: 16 AARGDVQEVRRLLHRELVHPDALNRFGKTALQ-VMMFGSTAIALELLKQGASPNVQDTSG 74
AAR EV + L + +A + +T L G T + LL+ A+PN+ T+G
Sbjct: 444 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG 503
Query: 75 TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAESDLHR 134
+P+H AAR G ++T+ L+E A G P+H+A + G V L E D H
Sbjct: 504 HTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELL-LERDAHP 562
Query: 135 RDA--RGLTPLELALQRGAQDLVDIL 158
A GLTPL +A+ D+V +L
Sbjct: 563 NAAGKNGLTPLHVAVHHNNLDIVKLL 588
Score = 62.4 bits (150), Expect = 2e-10
Identities = 45/152 (29%), Positives = 78/152 (51%), Gaps = 2/152 (1%)
Query: 16 AARGDVQEVRRLLHRELVHPDALNRFGKTALQVM-MFGSTAIALELLKQGASPNVQDTSG 74
AA+ + EV R L + +A + G T L + G + LL + A+ N+ + SG
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 668
Query: 75 TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAA-ESDLH 133
+P+H A+ G + VL++HG V+ G P+H+A G+ +V FL ++D++
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 728
Query: 134 RRDARGLTPLELALQRGAQDLVDILQGHMVAP 165
+ G +PL A Q+G D+V +L + +P
Sbjct: 729 AKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP 760
Score = 54.7 bits (130), Expect = 4e-08
Identities = 40/145 (27%), Positives = 72/145 (49%), Gaps = 2/145 (1%)
Query: 16 AARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMF-GSTAIALELLKQGASPNVQDTSG 74
AA+GD + RLL + D + T L V G +A LL +GA PN + +G
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG 371
Query: 75 TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVV-SFLAAESDLH 133
+P+H A + + +++L++ GA ++ +G P+H+A GH +V + L + +
Sbjct: 372 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431
Query: 134 RRDARGLTPLELALQRGAQDLVDIL 158
+ + TPL +A + G ++ L
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYL 456
Score = 52.8 bits (125), Expect = 1e-07
Identities = 34/109 (31%), Positives = 54/109 (49%), Gaps = 1/109 (0%)
Query: 24 VRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQGASPNVQDTSGTSPVHDAA 82
V +L + V DA R G T L V +G+ + LL+ A N + G SP+H AA
Sbjct: 683 VADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAA 742
Query: 83 RTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAESD 131
+ G D + +L+++GA N G P+ +A + G+ +V L +D
Sbjct: 743 QQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTD 791
Score = 41.2 bits (95), Expect = 4e-04
Identities = 27/76 (35%), Positives = 38/76 (50%), Gaps = 1/76 (1%)
Query: 81 AARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHT-AVVSFLAAESDLHRRDARG 139
AAR+G LD + +G D+N + G +HLA +EGH VV L E L +G
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78
Query: 140 LTPLELALQRGAQDLV 155
T L +A G ++V
Sbjct: 79 NTALHIAALAGQDEVV 94
Score = 38.5 bits (88), Expect = 0.003
Identities = 37/145 (25%), Positives = 63/145 (43%), Gaps = 6/145 (4%)
Query: 16 AARGDVQEVRRLLHRELVHPDALNRFGKTALQV-MMFGSTAIALELLKQGASPNVQDTSG 74
AA+ + EV + L + + G T L V + G + L+ G V+
Sbjct: 118 AAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR---- 173
Query: 75 TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAE-SDLH 133
+H AAR T VL+++ + +V TG P+H+A + V L + ++
Sbjct: 174 LPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN 233
Query: 134 RRDARGLTPLELALQRGAQDLVDIL 158
G+TPL +A +RG +V +L
Sbjct: 234 FTPQNGITPLHIASRRGNVIMVRLL 258
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 79.3 bits (194), Expect = 1e-15
Identities = 51/151 (33%), Positives = 80/151 (52%), Gaps = 3/151 (1%)
Query: 15 AAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTA-IALELLKQGASPNVQDTS 73
AA G V+ LL R+ HP+A + G T L V + + I LL +G SP+ +
Sbjct: 543 AAKYGKVRVAELLLERD-AHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWN 601
Query: 74 GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVS-FLAAESDL 132
G +P+H AA+ ++ + L+++G N G P+HLA QEGH +V+ L+ +++
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661
Query: 133 HRRDARGLTPLELALQRGAQDLVDILQGHMV 163
+ + GLTPL L Q G + D+L H V
Sbjct: 662 NLGNKSGLTPLHLVAQEGHVPVADVLIKHGV 692
Score = 69.7 bits (169), Expect = 1e-12
Identities = 40/113 (35%), Positives = 66/113 (58%), Gaps = 2/113 (1%)
Query: 15 AAARGDVQEVRRLLHRELVHPDALNRFGKTALQVM-MFGSTAIALELLKQGASPNVQDTS 73
A+ G V+ V LLH+E++ + + G TAL + + G + EL+ GA+ N Q
Sbjct: 52 ASKEGHVKMVVELLHKEIIL-ETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK 110
Query: 74 GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFL 126
G +P++ AA+ L+ +K L+E+GA+ NV G P+ +A+Q+GH VV+ L
Sbjct: 111 GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHL 163
Score = 68.6 bits (166), Expect = 2e-12
Identities = 49/158 (31%), Positives = 78/158 (49%), Gaps = 3/158 (1%)
Query: 4 EEVRAGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQ-VMMFGSTAIALELLK 62
E V+ L AA G + V LL ++ + + N+ G T L V G +A L+K
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQ-ANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689
Query: 63 QGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAV 122
G + G +P+H A+ G + +K L++H ADVN G P+H A Q+GHT +
Sbjct: 690 HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI 749
Query: 123 VSFLAAE-SDLHRRDARGLTPLELALQRGAQDLVDILQ 159
V+ L + + + G TPL +A + G + D+L+
Sbjct: 750 VTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK 787
Score = 67.8 bits (164), Expect = 4e-12
Identities = 46/134 (34%), Positives = 66/134 (49%), Gaps = 2/134 (1%)
Query: 24 VRRLLHRELVHPDALNRFGKTALQVMMF-GSTAIALELLKQGASPNVQDTSGTSPVHDAA 82
V LL + DA+ G T L V F G I LL++GASPNV + +P+H AA
Sbjct: 386 VMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAA 445
Query: 83 RTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAA-ESDLHRRDARGLT 141
R G + K L+++ A VN P+H A + GHT +V L ++ + G T
Sbjct: 446 RAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHT 505
Query: 142 PLELALQRGAQDLV 155
PL +A + G + V
Sbjct: 506 PLHIAAREGHVETV 519
Score = 65.5 bits (158), Expect = 2e-11
Identities = 41/145 (28%), Positives = 72/145 (49%), Gaps = 2/145 (1%)
Query: 16 AARGDVQEVRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQGASPNVQDTSG 74
AAR D +L + +PD L++ G T L + + + +A LL +GAS N +G
Sbjct: 180 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239
Query: 75 TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAE-SDLH 133
+P+H A+R G + +++L++ GA + P+H A + GH + L + +
Sbjct: 240 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 299
Query: 134 RRDARGLTPLELALQRGAQDLVDIL 158
+ GL+P+ +A Q D V +L
Sbjct: 300 AKTKNGLSPIHMAAQGDHLDCVRLL 324
Score = 65.5 bits (158), Expect = 2e-11
Identities = 48/146 (32%), Positives = 71/146 (48%), Gaps = 4/146 (2%)
Query: 16 AARGDVQEVRRLLHRELVHPDALNRFGKTALQ-VMMFGSTAIALELLKQGASPNVQDTSG 74
AAR EV + L + +A + +T L G T + LL+ A+PN+ T+G
Sbjct: 444 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG 503
Query: 75 TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAESDLHR 134
+P+H AAR G ++T+ L+E A G P+H+A + G V L E D H
Sbjct: 504 HTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELL-LERDAHP 562
Query: 135 RDA--RGLTPLELALQRGAQDLVDIL 158
A GLTPL +A+ D+V +L
Sbjct: 563 NAAGKNGLTPLHVAVHHNNLDIVKLL 588
Score = 62.4 bits (150), Expect = 2e-10
Identities = 45/152 (29%), Positives = 78/152 (51%), Gaps = 2/152 (1%)
Query: 16 AARGDVQEVRRLLHRELVHPDALNRFGKTALQVM-MFGSTAIALELLKQGASPNVQDTSG 74
AA+ + EV R L + +A + G T L + G + LL + A+ N+ + SG
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 668
Query: 75 TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAA-ESDLH 133
+P+H A+ G + VL++HG V+ G P+H+A G+ +V FL ++D++
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 728
Query: 134 RRDARGLTPLELALQRGAQDLVDILQGHMVAP 165
+ G +PL A Q+G D+V +L + +P
Sbjct: 729 AKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP 760
Score = 54.7 bits (130), Expect = 4e-08
Identities = 40/145 (27%), Positives = 72/145 (49%), Gaps = 2/145 (1%)
Query: 16 AARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMF-GSTAIALELLKQGASPNVQDTSG 74
AA+GD + RLL + D + T L V G +A LL +GA PN + +G
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG 371
Query: 75 TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVV-SFLAAESDLH 133
+P+H A + + +++L++ GA ++ +G P+H+A GH +V + L + +
Sbjct: 372 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431
Query: 134 RRDARGLTPLELALQRGAQDLVDIL 158
+ + TPL +A + G ++ L
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYL 456
Score = 52.8 bits (125), Expect = 1e-07
Identities = 34/109 (31%), Positives = 54/109 (49%), Gaps = 1/109 (0%)
Query: 24 VRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQGASPNVQDTSGTSPVHDAA 82
V +L + V DA R G T L V +G+ + LL+ A N + G SP+H AA
Sbjct: 683 VADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAA 742
Query: 83 RTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAESD 131
+ G D + +L+++GA N G P+ +A + G+ +V L +D
Sbjct: 743 QQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTD 791
Score = 41.2 bits (95), Expect = 4e-04
Identities = 27/76 (35%), Positives = 38/76 (50%), Gaps = 1/76 (1%)
Query: 81 AARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHT-AVVSFLAAESDLHRRDARG 139
AAR+G LD + +G D+N + G +HLA +EGH VV L E L +G
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78
Query: 140 LTPLELALQRGAQDLV 155
T L +A G ++V
Sbjct: 79 NTALHIAALAGQDEVV 94
Score = 38.5 bits (88), Expect = 0.003
Identities = 37/145 (25%), Positives = 63/145 (43%), Gaps = 6/145 (4%)
Query: 16 AARGDVQEVRRLLHRELVHPDALNRFGKTALQV-MMFGSTAIALELLKQGASPNVQDTSG 74
AA+ + EV + L + + G T L V + G + L+ G V+
Sbjct: 118 AAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR---- 173
Query: 75 TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAE-SDLH 133
+H AAR T VL+++ + +V TG P+H+A + V L + ++
Sbjct: 174 LPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN 233
Query: 134 RRDARGLTPLELALQRGAQDLVDIL 158
G+TPL +A +RG +V +L
Sbjct: 234 FTPQNGITPLHIASRRGNVIMVRLL 258
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 79.3 bits (194), Expect = 1e-15
Identities = 51/151 (33%), Positives = 80/151 (52%), Gaps = 3/151 (1%)
Query: 15 AAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTA-IALELLKQGASPNVQDTS 73
AA G V+ LL R+ HP+A + G T L V + + I LL +G SP+ +
Sbjct: 543 AAKYGKVRVAELLLERD-AHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWN 601
Query: 74 GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVS-FLAAESDL 132
G +P+H AA+ ++ + L+++G N G P+HLA QEGH +V+ L+ +++
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661
Query: 133 HRRDARGLTPLELALQRGAQDLVDILQGHMV 163
+ + GLTPL L Q G + D+L H V
Sbjct: 662 NLGNKSGLTPLHLVAQEGHVPVADVLIKHGV 692
Score = 69.7 bits (169), Expect = 1e-12
Identities = 40/113 (35%), Positives = 66/113 (58%), Gaps = 2/113 (1%)
Query: 15 AAARGDVQEVRRLLHRELVHPDALNRFGKTALQVM-MFGSTAIALELLKQGASPNVQDTS 73
A+ G V+ V LLH+E++ + + G TAL + + G + EL+ GA+ N Q
Sbjct: 52 ASKEGHVKMVVELLHKEIIL-ETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK 110
Query: 74 GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFL 126
G +P++ AA+ L+ +K L+E+GA+ NV G P+ +A+Q+GH VV+ L
Sbjct: 111 GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHL 163
Score = 68.6 bits (166), Expect = 2e-12
Identities = 49/158 (31%), Positives = 78/158 (49%), Gaps = 3/158 (1%)
Query: 4 EEVRAGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQ-VMMFGSTAIALELLK 62
E V+ L AA G + V LL ++ + + N+ G T L V G +A L+K
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQ-ANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689
Query: 63 QGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAV 122
G + G +P+H A+ G + +K L++H ADVN G P+H A Q+GHT +
Sbjct: 690 HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI 749
Query: 123 VSFLAAE-SDLHRRDARGLTPLELALQRGAQDLVDILQ 159
V+ L + + + G TPL +A + G + D+L+
Sbjct: 750 VTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK 787
Score = 67.8 bits (164), Expect = 4e-12
Identities = 46/134 (34%), Positives = 66/134 (49%), Gaps = 2/134 (1%)
Query: 24 VRRLLHRELVHPDALNRFGKTALQVMMF-GSTAIALELLKQGASPNVQDTSGTSPVHDAA 82
V LL + DA+ G T L V F G I LL++GASPNV + +P+H AA
Sbjct: 386 VMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAA 445
Query: 83 RTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAA-ESDLHRRDARGLT 141
R G + K L+++ A VN P+H A + GHT +V L ++ + G T
Sbjct: 446 RAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHT 505
Query: 142 PLELALQRGAQDLV 155
PL +A + G + V
Sbjct: 506 PLHIAAREGHVETV 519
Score = 65.5 bits (158), Expect = 2e-11
Identities = 41/145 (28%), Positives = 72/145 (49%), Gaps = 2/145 (1%)
Query: 16 AARGDVQEVRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQGASPNVQDTSG 74
AAR D +L + +PD L++ G T L + + + +A LL +GAS N +G
Sbjct: 180 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239
Query: 75 TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAE-SDLH 133
+P+H A+R G + +++L++ GA + P+H A + GH + L + +
Sbjct: 240 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 299
Query: 134 RRDARGLTPLELALQRGAQDLVDIL 158
+ GL+P+ +A Q D V +L
Sbjct: 300 AKTKNGLSPIHMAAQGDHLDCVRLL 324
Score = 65.5 bits (158), Expect = 2e-11
Identities = 48/146 (32%), Positives = 71/146 (48%), Gaps = 4/146 (2%)
Query: 16 AARGDVQEVRRLLHRELVHPDALNRFGKTALQ-VMMFGSTAIALELLKQGASPNVQDTSG 74
AAR EV + L + +A + +T L G T + LL+ A+PN+ T+G
Sbjct: 444 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG 503
Query: 75 TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAESDLHR 134
+P+H AAR G ++T+ L+E A G P+H+A + G V L E D H
Sbjct: 504 HTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELL-LERDAHP 562
Query: 135 RDA--RGLTPLELALQRGAQDLVDIL 158
A GLTPL +A+ D+V +L
Sbjct: 563 NAAGKNGLTPLHVAVHHNNLDIVKLL 588
Score = 62.4 bits (150), Expect = 2e-10
Identities = 45/152 (29%), Positives = 78/152 (51%), Gaps = 2/152 (1%)
Query: 16 AARGDVQEVRRLLHRELVHPDALNRFGKTALQVM-MFGSTAIALELLKQGASPNVQDTSG 74
AA+ + EV R L + +A + G T L + G + LL + A+ N+ + SG
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 668
Query: 75 TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAA-ESDLH 133
+P+H A+ G + VL++HG V+ G P+H+A G+ +V FL ++D++
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 728
Query: 134 RRDARGLTPLELALQRGAQDLVDILQGHMVAP 165
+ G +PL A Q+G D+V +L + +P
Sbjct: 729 AKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP 760
Score = 54.7 bits (130), Expect = 4e-08
Identities = 40/145 (27%), Positives = 72/145 (49%), Gaps = 2/145 (1%)
Query: 16 AARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMF-GSTAIALELLKQGASPNVQDTSG 74
AA+GD + RLL + D + T L V G +A LL +GA PN + +G
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG 371
Query: 75 TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVV-SFLAAESDLH 133
+P+H A + + +++L++ GA ++ +G P+H+A GH +V + L + +
Sbjct: 372 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431
Query: 134 RRDARGLTPLELALQRGAQDLVDIL 158
+ + TPL +A + G ++ L
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYL 456
Score = 52.8 bits (125), Expect = 1e-07
Identities = 34/109 (31%), Positives = 54/109 (49%), Gaps = 1/109 (0%)
Query: 24 VRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQGASPNVQDTSGTSPVHDAA 82
V +L + V DA R G T L V +G+ + LL+ A N + G SP+H AA
Sbjct: 683 VADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAA 742
Query: 83 RTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAESD 131
+ G D + +L+++GA N G P+ +A + G+ +V L +D
Sbjct: 743 QQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTD 791
Score = 41.2 bits (95), Expect = 4e-04
Identities = 27/76 (35%), Positives = 38/76 (50%), Gaps = 1/76 (1%)
Query: 81 AARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHT-AVVSFLAAESDLHRRDARG 139
AAR+G LD + +G D+N + G +HLA +EGH VV L E L +G
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78
Query: 140 LTPLELALQRGAQDLV 155
T L +A G ++V
Sbjct: 79 NTALHIAALAGQDEVV 94
Score = 38.5 bits (88), Expect = 0.003
Identities = 37/145 (25%), Positives = 63/145 (43%), Gaps = 6/145 (4%)
Query: 16 AARGDVQEVRRLLHRELVHPDALNRFGKTALQV-MMFGSTAIALELLKQGASPNVQDTSG 74
AA+ + EV + L + + G T L V + G + L+ G V+
Sbjct: 118 AAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR---- 173
Query: 75 TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAE-SDLH 133
+H AAR T VL+++ + +V TG P+H+A + V L + ++
Sbjct: 174 LPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN 233
Query: 134 RRDARGLTPLELALQRGAQDLVDIL 158
G+TPL +A +RG +V +L
Sbjct: 234 FTPQNGITPLHIASRRGNVIMVRLL 258
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 72.4 bits (176), Expect = 2e-13
Identities = 54/150 (36%), Positives = 78/150 (52%), Gaps = 4/150 (2%)
Query: 12 LSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMF-GSTAIALELLKQGASPNVQ 70
L AAA G ++ V+ LL R D N FG TAL + + G A+A+EL+ GA+ N
Sbjct: 210 LHTAAASGQIEVVKYLL-RMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQP 268
Query: 71 DTSGTSPVHDAA-RTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGH-TAVVSFLAA 128
+ G +P+H AA T L++LV +GADVN G P+H+A G T +
Sbjct: 269 NDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQN 328
Query: 129 ESDLHRRDARGLTPLELALQRGAQDLVDIL 158
S++ D G TPL +A + G + L+ L
Sbjct: 329 GSEIDCADKFGNTPLHVAARYGHELLISTL 358
Score = 63.5 bits (153), Expect = 8e-11
Identities = 52/169 (30%), Positives = 79/169 (46%), Gaps = 8/169 (4%)
Query: 1 MLLEEVRAGDRLSGAAARGDVQEVRRLLH--RELVHPDALNRFGKTALQV-MMFGSTAIA 57
++ E R L AAA G + L+ D ++ +G+T L + +M G
Sbjct: 645 LIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCV 704
Query: 58 LELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQE 117
LL++G++ + D G + +H A TG D L L++H A V D G PIHLA
Sbjct: 705 HLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASAC 764
Query: 118 GHTAVV-SFLAAESDLHRRDA----RGLTPLELALQRGAQDLVDILQGH 161
GHTAV+ + L A DA G +P+ A G +D +++L H
Sbjct: 765 GHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEH 813
Score = 58.5 bits (140), Expect = 2e-09
Identities = 47/145 (32%), Positives = 69/145 (47%), Gaps = 2/145 (1%)
Query: 16 AARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFG-STAIALELLKQGASPNVQDTSG 74
AA ++V LL +A ++ +T L V +T A L +S NV D SG
Sbjct: 81 AAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSG 140
Query: 75 TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAE-SDLH 133
S +H A +G L+T+ +L+ GA +NV D P+H A GH V+ L A +DL
Sbjct: 141 RSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLG 200
Query: 134 RRDARGLTPLELALQRGAQDLVDIL 158
+D +G L A G ++V L
Sbjct: 201 CKDRKGYGLLHTAAASGQIEVVKYL 225
Score = 58.2 bits (139), Expect = 3e-09
Identities = 46/141 (32%), Positives = 70/141 (49%), Gaps = 3/141 (2%)
Query: 20 DVQEVRRLLHRELVHPDALNRFGKTALQVMMF-GSTAIALELLKQGASPNVQDTSGTSPV 78
DV+EVR LL ++ + + L++ +T L + G I LL GA+ N +DT +P+
Sbjct: 20 DVEEVRSLLSQK-ENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPL 78
Query: 79 HDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLA-AESDLHRRDA 137
H AA + L +L+ H ADVN D P+H+A T LA S L+ D
Sbjct: 79 HRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADR 138
Query: 138 RGLTPLELALQRGAQDLVDIL 158
G + L A+ G + V++L
Sbjct: 139 SGRSALHHAVHSGHLETVNLL 159
Score = 57.4 bits (137), Expect = 6e-09
Identities = 38/110 (34%), Positives = 57/110 (51%), Gaps = 3/110 (2%)
Query: 60 LLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADV--NVPDGTGALPIHLAVQE 117
LL GA P+++D G + VH AA G L++L+E + +V P+HLA
Sbjct: 536 LLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYN 595
Query: 118 GHTAVVSFLAAE-SDLHRRDARGLTPLELALQRGAQDLVDILQGHMVAPL 166
GH + LA +L RD +G T L LA +RG+ + V++L H + L
Sbjct: 596 GHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASAL 645
Score = 55.5 bits (132), Expect = 2e-08
Identities = 44/121 (36%), Positives = 60/121 (49%), Gaps = 3/121 (2%)
Query: 39 NRFGKTALQ-VMMFGSTAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHG 97
+R G++AL + G LL +GAS NV D P+H AA G L+ LK+LV G
Sbjct: 137 DRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARG 196
Query: 98 ADVNVPDGTGALPIHLAVQEGHTAVVSF-LAAESDLHRRDARGLTPLELALQRGAQDLVD 156
AD+ D G +H A G VV + L +++ +A G T L +A G QD V
Sbjct: 197 ADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLG-QDAVA 255
Query: 157 I 157
I
Sbjct: 256 I 256
Score = 53.1 bits (126), Expect = 1e-07
Identities = 31/85 (36%), Positives = 45/85 (52%), Gaps = 2/85 (2%)
Query: 68 NVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFL- 126
N +D G +P+H AA + L++L++H A+VN D TG + A + G TA V FL
Sbjct: 852 NSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLL 911
Query: 127 -AAESDLHRRDARGLTPLELALQRG 150
++DL D T L LA +G
Sbjct: 912 YRGKADLTVLDENKNTALHLACSKG 936
Score = 47.8 bits (112), Expect = 4e-06
Identities = 27/88 (30%), Positives = 44/88 (50%), Gaps = 1/88 (1%)
Query: 60 LLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEG- 118
+L G N D G + +H AA G ++ L +L+ GAD+ D G P+H A G
Sbjct: 409 VLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGS 468
Query: 119 HTAVVSFLAAESDLHRRDARGLTPLELA 146
+ V+ + A + ++ D +G +PL A
Sbjct: 469 YQCAVTLVTAGAGVNEADCKGCSPLHYA 496
Score = 47.8 bits (112), Expect = 4e-06
Identities = 35/102 (34%), Positives = 53/102 (51%), Gaps = 8/102 (7%)
Query: 52 GSTAIALELLKQGASPNVQDT----SGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTG 107
G TA+ LL+ S + D SG SP+H A+ TG D L++L+EH + + +G
Sbjct: 765 GHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEH-SPFSYLEGNP 823
Query: 108 ALPIHLAV---QEGHTAVVSFLAAESDLHRRDARGLTPLELA 146
P+H AV Q+ T ++ ++ RDA+G TPL A
Sbjct: 824 FTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAA 865
Score = 43.9 bits (102), Expect = 6e-05
Identities = 42/134 (31%), Positives = 53/134 (39%), Gaps = 13/134 (9%)
Query: 39 NRFGKTALQVMMFGSTAIALELL-KQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHG 97
+ G+T L G L LL GA +D G +P+H AA G LV G
Sbjct: 420 DNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAG 479
Query: 98 ADVNVPDGTGALPIHLAV-------QEGHTAVVSFLAAESDLHRRDAR---GLTPLELAL 147
A VN D G P+H A E HT S AE D +++R LE L
Sbjct: 480 AGVNEADCKGCSPLHYAAASDTYRRAEPHTP--SSHDAEEDEPLKESRRKEAFFCLEFLL 537
Query: 148 QRGAQDLVDILQGH 161
GA + QG+
Sbjct: 538 DNGADPSLRDRQGY 551
Score = 43.5 bits (101), Expect = 8e-05
Identities = 34/126 (26%), Positives = 54/126 (42%), Gaps = 6/126 (4%)
Query: 42 GKTALQVMMFGSTAIALELLKQG-ASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHG-AD 99
G+T L F L +L Q A N D +G + + AA G ++ L+ G AD
Sbjct: 858 GRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKAD 917
Query: 100 VNVPDGTGALPIHLAVQEGHTAVVSFLAAESD----LHRRDARGLTPLELALQRGAQDLV 155
+ V D +HLA +GH + AE+ ++ ++ PL +A + G +V
Sbjct: 918 LTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVV 977
Query: 156 DILQGH 161
L H
Sbjct: 978 QALLSH 983
Score = 43.1 bits (100), Expect = 1e-04
Identities = 41/151 (27%), Positives = 64/151 (42%), Gaps = 7/151 (4%)
Query: 15 AAARGDVQEVRRLLHREL-VHPDALNRFGKTALQVMMFGSTAIALELLKQG-ASPNVQDT 72
AAA G+ Q + LL D + + L + + AL+ L + + +V+D
Sbjct: 557 AAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDH 616
Query: 73 SGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGA-LPIHLAVQEGHTAVVSFLAAESD 131
G + + A G + ++VL HGA + + P+H A GHT + L +
Sbjct: 617 KGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGE 676
Query: 132 ----LHRRDARGLTPLELALQRGAQDLVDIL 158
DA G TPL LA+ G D V +L
Sbjct: 677 RADITDVMDAYGQTPLMLAIMNGHVDCVHLL 707
Score = 36.6 bits (83), Expect = 0.010
Identities = 37/122 (30%), Positives = 52/122 (42%), Gaps = 12/122 (9%)
Query: 1 MLLE---EVRAGDR-----LSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMF- 51
MLL+ EV A D L AA G V LL+R L+ TAL +
Sbjct: 876 MLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSK 935
Query: 52 GSTAIALELLKQGASPNVQDTSGTS---PVHDAARTGFLDTLKVLVEHGADVNVPDGTGA 108
G AL +L + + + + ++ P+H AAR G ++ L+ HGA V D G
Sbjct: 936 GHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGH 995
Query: 109 LP 110
P
Sbjct: 996 TP 997
Score = 34.7 bits (78), Expect = 0.038
Identities = 34/137 (24%), Positives = 61/137 (44%), Gaps = 7/137 (5%)
Query: 12 LSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALELL--KQGASPNV 69
L AA +V +R LL + +A + G+TAL A+E L + A V
Sbjct: 862 LHAAAFADNVSGLRMLLQHQ-AEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTV 920
Query: 70 QDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGA---LPIHLAVQEGHTAVV-SF 125
D + + +H A G +++ D+ + + T + +P+H+A + G +VV +
Sbjct: 921 LDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQAL 980
Query: 126 LAAESDLHRRDARGLTP 142
L+ + + D G TP
Sbjct: 981 LSHGATVLAVDEEGHTP 997
Score = 30.4 bits (67), Expect = 0.73
Identities = 19/86 (22%), Positives = 41/86 (47%), Gaps = 1/86 (1%)
Query: 77 PVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVS-FLAAESDLHRR 135
P+ A + ++ ++ L+ ++NV D P+H A G ++ L + ++++ +
Sbjct: 11 PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAK 70
Query: 136 DARGLTPLELALQRGAQDLVDILQGH 161
D LTPL A + ++ +L H
Sbjct: 71 DTLWLTPLHRAAASRNEKVLGLLLAH 96
>gi|218505706 ankyrin repeat and SOCS box-containing 14 isoform 1
[Homo sapiens]
Length = 423
Score = 72.0 bits (175), Expect = 2e-13
Identities = 44/144 (30%), Positives = 76/144 (52%), Gaps = 1/144 (0%)
Query: 16 AARGDVQEVRRLLHRELVHPDALNRFGKTALQVM-MFGSTAIALELLKQGASPNVQDTSG 74
AA+ +++ +L+ HPD + +G T L + G T I LL++GA+ + Q +
Sbjct: 26 AAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEIMEMLLRKGANAHGQASDS 85
Query: 75 TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAESDLHR 134
+S + +AA G D + +L+E+GAD N+P +G LPIH+A GH + L +DL
Sbjct: 86 SSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHLLALKILIPVTDLAA 145
Query: 135 RDARGLTPLELALQRGAQDLVDIL 158
G++P+ A +++L
Sbjct: 146 IKQSGISPVHCAAAGAHPQCLELL 169
Score = 43.9 bits (102), Expect = 6e-05
Identities = 29/104 (27%), Positives = 53/104 (50%), Gaps = 1/104 (0%)
Query: 56 IALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAV 115
+A L+ GA N++ + + +H+AA+ G D +K+++ GA + G P+ LA
Sbjct: 1 MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAA 60
Query: 116 QEGHTAVVSFLAAE-SDLHRRDARGLTPLELALQRGAQDLVDIL 158
Q GHT ++ L + ++ H + + + L A G D V +L
Sbjct: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALL 104
Score = 35.8 bits (81), Expect = 0.017
Identities = 28/98 (28%), Positives = 44/98 (44%), Gaps = 11/98 (11%)
Query: 73 SGTSPVHDAARTGFLDTLKVLVEHGADVNVP---------DGTGALPIHLAVQEGHTAVV 123
SG SPVH AA L++L++ G DVN D ++ AV + V
Sbjct: 149 SGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSV 208
Query: 124 SFLAAESDLHRRDARGLTPLELALQRGAQDLVDILQGH 161
L + L +D + L++AL+ G +L+ +L H
Sbjct: 209 KLLLSAGALPNQDP--VNCLQIALRMGNYELISLLLRH 244
Score = 26.9 bits (58), Expect = 8.0
Identities = 21/60 (35%), Positives = 32/60 (53%), Gaps = 4/60 (6%)
Query: 43 KTALQVMMFGSTAIALELL-KQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVN 101
K+AL + S +++LL GA PN QD + A R G + + +L+ HGA+VN
Sbjct: 193 KSALYFAVSNSDLSSVKLLLSAGALPN-QDPVNCLQI--ALRMGNYELISLLLRHGANVN 249
>gi|116875852 HECT domain and ankyrin repeat containing, E3
ubiquitin protein ligase 1 [Homo sapiens]
Length = 909
Score = 71.6 bits (174), Expect = 3e-13
Identities = 43/108 (39%), Positives = 58/108 (53%), Gaps = 1/108 (0%)
Query: 52 GSTAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPI 111
GS + LLK+GA+PN QD SG +P+H AAR G + L+E+ ADVN+ + G I
Sbjct: 76 GSVECLVLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEYSADVNICNNEGLTAI 135
Query: 112 HLAVQEGHTAVVSFLAAE-SDLHRRDARGLTPLELALQRGAQDLVDIL 158
H G T ++ L SD+ DA G T L +A Q G + V L
Sbjct: 136 HWLAVNGRTELLHDLVQHVSDVDVEDAMGQTALHVACQNGHKTTVQCL 183
Score = 64.7 bits (156), Expect = 3e-11
Identities = 35/121 (28%), Positives = 64/121 (52%), Gaps = 1/121 (0%)
Query: 39 NRFGKTALQ-VMMFGSTAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHG 97
N G TA+ + + G T + +L++ + +V+D G + +H A + G T++ L++ G
Sbjct: 128 NNEGLTAIHWLAVNGRTELLHDLVQHVSDVDVEDAMGQTALHVACQNGHKTTVQCLLDSG 187
Query: 98 ADVNVPDGTGALPIHLAVQEGHTAVVSFLAAESDLHRRDARGLTPLELALQRGAQDLVDI 157
AD+N P+ +GA P++ A G L + D G+TPL+L +Q G + ++
Sbjct: 188 ADINRPNVSGATPLYFACSHGQRDTAQILLLRGAKYLPDKNGVTPLDLCVQGGYGETCEV 247
Query: 158 L 158
L
Sbjct: 248 L 248
Score = 43.1 bits (100), Expect = 1e-04
Identities = 27/88 (30%), Positives = 46/88 (52%), Gaps = 1/88 (1%)
Query: 76 SPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVS-FLAAESDLHR 134
S +H AA G ++ L +L++ GA+ N D +G P+HLA + G +S L +D++
Sbjct: 67 SLLHIAANCGSVECLVLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEYSADVNI 126
Query: 135 RDARGLTPLELALQRGAQDLVDILQGHM 162
+ GLT + G +L+ L H+
Sbjct: 127 CNNEGLTAIHWLAVNGRTELLHDLVQHV 154
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 70.9 bits (172), Expect = 5e-13
Identities = 57/177 (32%), Positives = 80/177 (45%), Gaps = 24/177 (13%)
Query: 12 LSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGST---------AIALELLK 62
L AAA+G E+ +LL + P NR G T L ++ G T A L+ K
Sbjct: 754 LHEAAAKGKY-EICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAK 812
Query: 63 QGASPNVQ-----------DTSG--TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGAL 109
+G VQ DT G ++P+H AA L+ + L+EHGADVN D G +
Sbjct: 813 KGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLI 872
Query: 110 PIHLAVQEGHTAVVSFLAAESD-LHRRDARGLTPLELALQRGAQDLVDILQGHMVAP 165
P+H A GH + + L + ++ D TPL A Q+G L +L H P
Sbjct: 873 PLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADP 929
Score = 66.6 bits (161), Expect = 9e-12
Identities = 46/152 (30%), Positives = 76/152 (50%), Gaps = 3/152 (1%)
Query: 11 RLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQGASPNV 69
RL A+ GD++ V++L + V+ L T L + ++ LL GA +
Sbjct: 653 RLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHA 712
Query: 70 QDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAE 129
+D G P+H+A G + ++LV HGA VNV D P+H A +G + L
Sbjct: 713 KDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKH 772
Query: 130 -SDLHRRDARGLTPLELALQRGAQDLVDILQG 160
+D +++ G TPL+L ++ G D+ D+L+G
Sbjct: 773 GADPTKKNRDGNTPLDL-VKEGDTDIQDLLRG 803
Score = 66.2 bits (160), Expect = 1e-11
Identities = 45/147 (30%), Positives = 75/147 (51%), Gaps = 3/147 (2%)
Query: 3 LEEVRAGDR-LSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALEL 60
++++ GD L AA +G + V++L E ++ T L + + + +A L
Sbjct: 797 IQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYL 856
Query: 61 LKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHT 120
L+ GA N QD G P+H+AA G +D +L+++ VN D P+H A Q+G T
Sbjct: 857 LEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRT 916
Query: 121 AVVSFLAAE-SDLHRRDARGLTPLELA 146
+ + L A +D ++ G TPL+LA
Sbjct: 917 QLCALLLAHGADPTMKNQEGQTPLDLA 943
Score = 55.1 bits (131), Expect = 3e-08
Identities = 40/134 (29%), Positives = 62/134 (46%), Gaps = 2/134 (1%)
Query: 15 AAARGDVQEVRRLLHRELVHP-DALNRFGKTALQVMMFGSTAIALELLKQGASPNVQDTS 73
A GDV V+RL+ V+ D R FG + LL+ GA+ + +D
Sbjct: 189 ACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDG 248
Query: 74 GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAV-VSFLAAESDL 132
G P+H+A G + + +L+ GAD N D P+H A +G V + L +D
Sbjct: 249 GLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADP 308
Query: 133 HRRDARGLTPLELA 146
+ R+ G + L+LA
Sbjct: 309 NIRNTDGKSALDLA 322
Score = 55.1 bits (131), Expect = 3e-08
Identities = 44/166 (26%), Positives = 62/166 (37%), Gaps = 55/166 (33%)
Query: 51 FGSTAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNV--PDGTGA 108
FG + LL QGA PN +D +P+H+AA G +D VL++HGAD N+ DG A
Sbjct: 259 FGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSA 318
Query: 109 L----------------------------------------------------PIHLAVQ 116
L P+HLA
Sbjct: 319 LDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAG 378
Query: 117 EGHTAVVSFLAAE-SDLHRRDARGLTPLELALQRGAQDLVDILQGH 161
+V L +D+H +D GL PL A G ++ ++L H
Sbjct: 379 YNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKH 424
Score = 50.1 bits (118), Expect = 9e-07
Identities = 48/175 (27%), Positives = 77/175 (44%), Gaps = 34/175 (19%)
Query: 17 ARGDVQEVRRLLHRELVHPDALNRFGKTAL-QVMMFGSTAIALELLKQGASPNV------ 69
A DV EV LH+ +AL+ G+TAL + + G LL G+ P++
Sbjct: 569 AHNDVMEV---LHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGF 625
Query: 70 -----------QDTSGTSPVH---------DAARTGFLDTLKVLVEHGADVNVPD--GTG 107
Q S ++P+ +A++ G L+T+K L +VN D G
Sbjct: 626 TAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCS-SQNVNCRDLEGRH 684
Query: 108 ALPIHLAVQEGHTAVVSFLAAE-SDLHRRDARGLTPLELALQRGAQDLVDILQGH 161
+ P+H A +VV +L +D+H +D GL PL A G ++ ++L H
Sbjct: 685 STPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRH 739
Score = 48.5 bits (114), Expect = 3e-06
Identities = 35/118 (29%), Positives = 55/118 (46%), Gaps = 1/118 (0%)
Query: 10 DRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQGASPN 68
D L AA G+ +++ LL V+ A + T L + + I LL+ GA +
Sbjct: 337 DELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVH 396
Query: 69 VQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFL 126
+D G P+H+A G + ++L++HGA VN D P+H A + V S L
Sbjct: 397 AKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLL 454
Score = 47.4 bits (111), Expect = 6e-06
Identities = 32/114 (28%), Positives = 55/114 (48%), Gaps = 3/114 (2%)
Query: 9 GDRLSGAAARGDVQEVRRLLHRELVH---PDALNRFGKTALQVMMFGSTAIALELLKQGA 65
G L AA D+ +V++ L E+++ P + A+ + + LL++GA
Sbjct: 490 GHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGA 549
Query: 66 SPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGH 119
+ N ++ +P+H AA D ++VL +HGA +N D G +H A GH
Sbjct: 550 NVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGH 603
Score = 43.9 bits (102), Expect = 6e-05
Identities = 34/116 (29%), Positives = 56/116 (48%), Gaps = 5/116 (4%)
Query: 22 QEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALELL-KQGASPNVQDTSGTSPVHD 80
++V LL R+ + + N+ T L V + +E+L K GA N DT G + +H
Sbjct: 538 KQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHR 597
Query: 81 AARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAESDLHRRD 136
AA G L T ++L+ +G+D ++ G A Q G+ AV L+ + + D
Sbjct: 598 AALAGHLQTCRLLLSYGSDPSIISLQG----FTAAQMGNEAVQQILSESTPIRTSD 649
Score = 41.2 bits (95), Expect = 4e-04
Identities = 22/73 (30%), Positives = 36/73 (49%)
Query: 51 FGSTAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALP 110
+G IA L+K N D +P+H+AA+ G +L+ HGAD + + G P
Sbjct: 880 YGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTP 939
Query: 111 IHLAVQEGHTAVV 123
+ LA + A++
Sbjct: 940 LDLATADDIRALL 952
Score = 38.9 bits (89), Expect = 0.002
Identities = 29/82 (35%), Positives = 42/82 (51%), Gaps = 4/82 (4%)
Query: 80 DAARTGFLDTLKVLVEHGADVNVPDGTG--ALPIHLAVQEGHTAVVS-FLAAESDLHRRD 136
+A R G + +K LV+ A+VN D G + P+H A G VV L +++H RD
Sbjct: 188 EACRNGDVSRVKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARD 246
Query: 137 ARGLTPLELALQRGAQDLVDIL 158
GL PL A G ++V +L
Sbjct: 247 DGGLIPLHNACSFGHAEVVSLL 268
Score = 36.6 bits (83), Expect = 0.010
Identities = 19/64 (29%), Positives = 32/64 (50%)
Query: 51 FGSTAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALP 110
+G + LLK GA N D +P+H+AA ++ +L+ HGAD + + G
Sbjct: 412 YGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSA 471
Query: 111 IHLA 114
+ +A
Sbjct: 472 VDMA 475
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 70.5 bits (171), Expect = 6e-13
Identities = 53/158 (33%), Positives = 78/158 (49%), Gaps = 3/158 (1%)
Query: 3 LEEVRAGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALE-LL 61
L E L AA G V V+ LL + DA R +T L + + A++ LL
Sbjct: 489 LHEAEGKTPLHVAAYFGHVSLVK-LLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLL 547
Query: 62 KQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTA 121
K GA P+ D SG P+H AA G K+L+ +GA + +P G P+HLA +GH
Sbjct: 548 KSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLE 607
Query: 122 VVSFLA-AESDLHRRDARGLTPLELALQRGAQDLVDIL 158
++ LA + +++ A TPL LA + G + +V L
Sbjct: 608 IIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSAL 645
Score = 69.7 bits (169), Expect = 1e-12
Identities = 52/149 (34%), Positives = 79/149 (53%), Gaps = 5/149 (3%)
Query: 15 AAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQGASPNVQDTS 73
AA +G + E+ LL + AL T L + G A+ LL+ GA PN + S
Sbjct: 600 AAYKGHL-EIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQS 658
Query: 74 GTSPVHDAA-RTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLA-AESD 131
G +P+H A R+ FL + +L EH A+V+ + G P HLA +G+TA++ L A +
Sbjct: 659 GWTPLHLAVQRSTFLSVINLL-EHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQ 717
Query: 132 LHRRDARGLTPLELALQRGAQDLVDILQG 160
L +D TPL+LAL+ Q ++ L+G
Sbjct: 718 LDVQDGVSCTPLQLALRSRKQGIMSFLEG 746
Score = 68.9 bits (167), Expect = 2e-12
Identities = 50/144 (34%), Positives = 72/144 (50%), Gaps = 3/144 (2%)
Query: 17 ARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTA-IALELLKQGASPNVQDTSGT 75
A+G V++VR LL E V D G T L + + LL GA N D G
Sbjct: 371 AQGSVEQVRLLLAHE-VDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGW 429
Query: 76 SPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAA-ESDLHR 134
+P+H AA+ G T ++L++HGA V+ + G P+HLA Q V L + ++D +
Sbjct: 430 APLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNL 489
Query: 135 RDARGLTPLELALQRGAQDLVDIL 158
+A G TPL +A G LV +L
Sbjct: 490 HEAEGKTPLHVAAYFGHVSLVKLL 513
Score = 64.7 bits (156), Expect = 3e-11
Identities = 38/102 (37%), Positives = 56/102 (54%), Gaps = 5/102 (4%)
Query: 52 GSTAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPI 111
G A LL GA + Q+ G +P+H AA+ F + ++LV AD N+ + G P+
Sbjct: 439 GDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPL 498
Query: 112 HLAVQEGHTAVVSFL---AAESDLHRRDARGLTPLELALQRG 150
H+A GH ++V L AE D +R+ R TPL LA++RG
Sbjct: 499 HVAAYFGHVSLVKLLTSQGAELDAQQRNLR--TPLHLAVERG 538
Score = 55.5 bits (132), Expect = 2e-08
Identities = 44/139 (31%), Positives = 63/139 (45%), Gaps = 5/139 (3%)
Query: 15 AAARGDVQEVRRLL-HRELVHPDALNRFGKTALQVMMFGSTA-IALELLKQGASPNVQDT 72
AA GD R LL H V DA R G T L + + +A L+ + A PN+ +
Sbjct: 435 AAQNGDDGTARLLLDHGACV--DAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEA 492
Query: 73 SGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAESDL 132
G +P+H AA G + +K+L GA+++ P+HLAV+ G + L +
Sbjct: 493 EGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAV 552
Query: 133 -HRRDARGLTPLELALQRG 150
D G PL A RG
Sbjct: 553 PDALDQSGYGPLHTAAARG 571
Score = 42.7 bits (99), Expect = 1e-04
Identities = 24/87 (27%), Positives = 42/87 (48%), Gaps = 1/87 (1%)
Query: 76 SPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAE-SDLHR 134
+P+H G ++ +++L+ H DV+ +G P+ +A Q+ + + L A +D +R
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423
Query: 135 RDARGLTPLELALQRGAQDLVDILQGH 161
D G PL A Q G +L H
Sbjct: 424 VDEDGWAPLHFAAQNGDDGTARLLLDH 450
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 70.1 bits (170), Expect = 8e-13
Identities = 58/177 (32%), Positives = 83/177 (46%), Gaps = 24/177 (13%)
Query: 12 LSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGST---------AIALELLK 62
L AAA+G E+ +LL + P NR G T L ++ G T A L+ K
Sbjct: 596 LHEAAAKGKY-EICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAK 654
Query: 63 QG--------ASP---NVQDTSG--TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGAL 109
+G +SP N +DT G ++P+H AA L+ + L++HGADVN D G +
Sbjct: 655 KGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLI 714
Query: 110 PIHLAVQEGHTAVVSFLAA-ESDLHRRDARGLTPLELALQRGAQDLVDILQGHMVAP 165
P+H A GH V + L + ++ D TPL A Q+G L +L H P
Sbjct: 715 PLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADP 771
Score = 66.2 bits (160), Expect = 1e-11
Identities = 49/163 (30%), Positives = 80/163 (49%), Gaps = 6/163 (3%)
Query: 3 LEEVRAGDR-LSGAAARGDVQEVRRLLHRELVH-PDALNRFGKTALQVMMFGSTAIALEL 60
++++ GD L AA +G + V++L + V+ D R + + +A L
Sbjct: 639 IQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYL 698
Query: 61 LKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHT 120
L+ GA N QD G P+H+AA G +D +L+++ A VN D P+H A Q+G T
Sbjct: 699 LQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRT 758
Query: 121 AVVSFLAAE-SDLHRRDARGLTPLELALQRGAQDLVDILQGHM 162
+ + L A +D ++ G TPL+L A D+ +L M
Sbjct: 759 QLCALLLAHGADPTLKNQEGQTPLDLV---SADDVSALLTAAM 798
Score = 65.9 bits (159), Expect = 2e-11
Identities = 47/155 (30%), Positives = 79/155 (50%), Gaps = 3/155 (1%)
Query: 8 AGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQGAS 66
A +L AA GDV+ V++L + V+ + T L + ++ LL+ GA
Sbjct: 492 ADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGAD 551
Query: 67 PNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFL 126
+ +D G P+H+A G + ++LV+HGA VNV D P+H A +G + L
Sbjct: 552 VHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLL 611
Query: 127 AAE-SDLHRRDARGLTPLELALQRGAQDLVDILQG 160
+D +++ G TPL+L ++ G D+ D+L+G
Sbjct: 612 LQHGADPTKKNRDGNTPLDL-VKDGDTDIQDLLRG 645
Score = 61.2 bits (147), Expect = 4e-10
Identities = 46/143 (32%), Positives = 64/143 (44%), Gaps = 6/143 (4%)
Query: 8 AGDRLSGAAARGDVQEVRRLLHRELVHP-DALNRFGKTALQVMMFGSTAIALELLKQGAS 66
A L A GDV+ V+RL+ E V+ D R FG + LL+ GA+
Sbjct: 24 AARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGAN 83
Query: 67 PNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFL 126
+D G P+H+A G + + +L+ HGAD N D P+H A +G V L
Sbjct: 84 VQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVL 143
Query: 127 ---AAESDLHRRDARGLTPLELA 146
AE + D R T L+LA
Sbjct: 144 LQHGAEPTIRNTDGR--TALDLA 164
Score = 48.9 bits (115), Expect = 2e-06
Identities = 44/155 (28%), Positives = 67/155 (43%), Gaps = 8/155 (5%)
Query: 9 GDRLSGAAARGDVQEVRRLLHRELV---HPDALNRFGKTALQVMMFGSTAIALELLKQGA 65
G L AA DV +++ L E+V HP A I LL++GA
Sbjct: 332 GHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGA 391
Query: 66 SPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSF 125
+ N + +P+H A+ D ++V+V+H A VN D G +H A GH
Sbjct: 392 NINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRL 451
Query: 126 LAAES-DLHRRDARGLTPLELALQRGAQDLVDILQ 159
L + D + +G T ALQ G +++ +LQ
Sbjct: 452 LLSYGCDPNIISLQGFT----ALQMGNENVQQLLQ 482
Score = 48.1 bits (113), Expect = 3e-06
Identities = 39/162 (24%), Positives = 70/162 (43%), Gaps = 23/162 (14%)
Query: 23 EVRRLLHRELVHPDALNRFGKTAL-QVMMFGSTAIALELLKQGASPNVQDTSGTSPVH-- 79
EV LL R P+A + + T L + + G + + LL+ GA P +++T G + +
Sbjct: 105 EVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLA 164
Query: 80 ------------------DAARTGFLDTLKVLVEH-GADVNVPDGTGALPIHLAVQEGHT 120
++AR+G + + L+ + + DG + P+HLA
Sbjct: 165 DPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRV 224
Query: 121 AVVSFLAAE-SDLHRRDARGLTPLELALQRGAQDLVDILQGH 161
+V L +D+H +D L PL A G ++ ++L H
Sbjct: 225 KIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKH 266
Score = 47.0 bits (110), Expect = 7e-06
Identities = 40/151 (26%), Positives = 65/151 (43%), Gaps = 7/151 (4%)
Query: 10 DRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQGASPN 68
D L +A G+ +++ LL V+ A + T L + + I LL+ GA +
Sbjct: 179 DELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVH 238
Query: 69 VQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAA 128
+D P+H+A G + ++LV+HGA VN D P+H A + V S L +
Sbjct: 239 AKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLS 298
Query: 129 ES------DLHRRDARGLTPLELALQRGAQD 153
+ H + A L P +R A +
Sbjct: 299 YGADPTLLNCHNKSAIDLAPTPQLKERLAYE 329
Score = 46.6 bits (109), Expect = 1e-05
Identities = 46/153 (30%), Positives = 77/153 (50%), Gaps = 11/153 (7%)
Query: 12 LSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALELLKQGASPNVQD 71
L AA G +Q R LL P+ ++ G TALQ+ G+ + +LL++G S + +
Sbjct: 437 LHRAAYCGHLQTCRLLLSYGC-DPNIISLQGFTALQM---GNENVQ-QLLQEGIS--LGN 489
Query: 72 TSGTSPVHDAARTGFLDTLKVLVEHGADVNVPD--GTGALPIHLAVQEGHTAVVSFLAAE 129
+ + +AA+ G ++T+K L + VN D G + P+H A +VV +L
Sbjct: 490 SEADRQLLEAAKAGDVETVKKLCTVQS-VNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQH 548
Query: 130 -SDLHRRDARGLTPLELALQRGAQDLVDILQGH 161
+D+H +D GL PL A G ++ ++L H
Sbjct: 549 GADVHAKDKGGLVPLHNACSYGHYEVAELLVKH 581
>gi|39812133 ankyrin repeat domain 2 isoform a [Homo sapiens]
Length = 360
Score = 69.7 bits (169), Expect = 1e-12
Identities = 47/149 (31%), Positives = 79/149 (53%), Gaps = 3/149 (2%)
Query: 15 AAARGDVQEVRRLLHRELVHPDALNRFGKTAL-QVMMFGSTAIALELLKQGASPNVQDTS 73
AA G ++ + + L + D ++F +TAL + + G I +LL GA+ + QD
Sbjct: 155 AAVEGKMKVIEKFL-ADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRL 213
Query: 74 GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVS-FLAAESDL 132
+ +H A R G L+ +K+L HGAD NV D + P+H+AV+ G +V FL+ ++
Sbjct: 214 DCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEI 273
Query: 133 HRRDARGLTPLELALQRGAQDLVDILQGH 161
+ RD G T L A++ ++ +L H
Sbjct: 274 NARDREGDTALHDAVRLNRYKIIKLLLLH 302
Score = 51.6 bits (122), Expect = 3e-07
Identities = 32/115 (27%), Positives = 59/115 (51%), Gaps = 1/115 (0%)
Query: 43 KTALQVMMFGSTAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNV 102
+T L+ + G + + L G S + D + +H A+ G ++ L+ L+++GA V+
Sbjct: 150 ETFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDF 209
Query: 103 PDGTGALPIHLAVQEGHTAVVSFLAAE-SDLHRRDARGLTPLELALQRGAQDLVD 156
D +H A + GH VV L + +D + RD TPL +A++ G ++V+
Sbjct: 210 QDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVE 264
Score = 43.1 bits (100), Expect = 1e-04
Identities = 30/99 (30%), Positives = 43/99 (43%), Gaps = 1/99 (1%)
Query: 16 AARGDVQEVRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQGASPNVQDTSG 74
A RG EV +LL + ++ T L V + G I L G N +D G
Sbjct: 221 ACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREG 280
Query: 75 TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHL 113
+ +HDA R +K+L+ HGAD+ + G P L
Sbjct: 281 DTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDL 319
>gi|18079216 CASK interacting protein 1 [Homo sapiens]
Length = 1431
Score = 67.8 bits (164), Expect = 4e-12
Identities = 42/125 (33%), Positives = 67/125 (53%), Gaps = 5/125 (4%)
Query: 35 PDALNRFGKTALQVMMFGSTAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLV 94
PD + AL G+T + LL+ A+ +++D G P+H AA G + +K+++
Sbjct: 47 PDGFSALHHAALN----GNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVL 102
Query: 95 EHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAA-ESDLHRRDARGLTPLELALQRGAQD 153
+ G+ VN+P G +P+HLA Q GH V L +S+ D G TPL+LA + G
Sbjct: 103 KAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVG 162
Query: 154 LVDIL 158
+V +L
Sbjct: 163 VVQLL 167
Score = 52.8 bits (125), Expect = 1e-07
Identities = 33/99 (33%), Positives = 48/99 (48%), Gaps = 1/99 (1%)
Query: 68 NVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSF-L 126
N QD G S +H AA G + + +L+E A V++ D G P+H A +G + L
Sbjct: 43 NFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVL 102
Query: 127 AAESDLHRRDARGLTPLELALQRGAQDLVDILQGHMVAP 165
A S ++ G PL LA Q G D+ ++L H P
Sbjct: 103 KAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNP 141
Score = 52.8 bits (125), Expect = 1e-07
Identities = 31/108 (28%), Positives = 54/108 (50%), Gaps = 9/108 (8%)
Query: 60 LLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGH 119
+LK G++ N+ G P+H AA+ G D ++L++H ++ + D +G P+ LA + G
Sbjct: 101 VLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGR 160
Query: 120 TAVVSFLAAESDL---------HRRDARGLTPLELALQRGAQDLVDIL 158
VV L + + D G +PL LA + G D++ +L
Sbjct: 161 VGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLL 208
Score = 48.9 bits (115), Expect = 2e-06
Identities = 40/143 (27%), Positives = 66/143 (46%), Gaps = 11/143 (7%)
Query: 16 AARGDVQEVRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQGASP------- 67
AA+ +V +L + +P ++ GKT L + FG + LL
Sbjct: 122 AAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLEPRP 181
Query: 68 -NVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFL 126
+ D +GTSP+H AA+ G +D +++L++ G D+N +G +H A G T VV L
Sbjct: 182 GDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSGT-ALHEAALCGKTEVVRLL 240
Query: 127 AAES-DLHRRDARGLTPLELALQ 148
+ H R+ T L++ Q
Sbjct: 241 LDSGINAHVRNTYSQTALDIVHQ 263
Score = 38.5 bits (88), Expect = 0.003
Identities = 31/110 (28%), Positives = 53/110 (48%), Gaps = 14/110 (12%)
Query: 60 LLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHG----------ADVNVPDGTGAL 109
LL+ ++P + D SG +P+ A G + +++L+ D P+GT
Sbjct: 134 LLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTS-- 191
Query: 110 PIHLAVQEGHTAVVS-FLAAESDLHRRDARGLTPLELALQRGAQDLVDIL 158
P+HLA + GH ++ L A D++R+ G T L A G ++V +L
Sbjct: 192 PLHLAAKNGHIDIIRLLLQAGIDINRQTKSG-TALHEAALCGKTEVVRLL 240
Score = 31.2 bits (69), Expect = 0.43
Identities = 17/56 (30%), Positives = 31/56 (55%), Gaps = 1/56 (1%)
Query: 99 DVNVPDGTGALPIHLAVQEGHTAVVS-FLAAESDLHRRDARGLTPLELALQRGAQD 153
+VN D G +H A G+T ++S L A++ + +D +G+ PL A +G ++
Sbjct: 41 NVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKE 96
>gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens]
Length = 983
Score = 67.8 bits (164), Expect = 4e-12
Identities = 49/146 (33%), Positives = 77/146 (52%), Gaps = 3/146 (2%)
Query: 15 AAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALELLKQGASPNVQ-DTS 73
AAA+G V E R++ V A + G +AL + S + L Q P D+S
Sbjct: 63 AAAKGHV-ECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSS 121
Query: 74 GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAE-SDL 132
G + +H AA G L +++L EH + +N+ D G +P+ LAVQ GH+ + FL +D+
Sbjct: 122 GKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADV 181
Query: 133 HRRDARGLTPLELALQRGAQDLVDIL 158
+ R+ G T L LA + G+ + V+ L
Sbjct: 182 NSRNKSGRTALMLACEIGSSNAVEAL 207
Score = 60.5 bits (145), Expect = 7e-10
Identities = 40/125 (32%), Positives = 57/125 (45%), Gaps = 2/125 (1%)
Query: 39 NRFGKTALQVMMFGSTAIALELL-KQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHG 97
N+ LQ + G LL K+GAS D+ G + H AA G ++ L+V++ HG
Sbjct: 20 NKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHG 79
Query: 98 ADVNVPDGTGALPIHLAVQEG-HTAVVSFLAAESDLHRRDARGLTPLELALQRGAQDLVD 156
DV D TG +HLA + H + L ++ D+ G T L A +G V
Sbjct: 80 VDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQ 139
Query: 157 ILQGH 161
IL H
Sbjct: 140 ILCEH 144
Score = 29.3 bits (64), Expect = 1.6
Identities = 20/69 (28%), Positives = 33/69 (47%), Gaps = 4/69 (5%)
Query: 39 NRFGKTALQVMM-FGSTAIALELLKQGASPNVQDTSGTSPVHD---AARTGFLDTLKVLV 94
N+ G+TAL + GS+ L+K+GA N+ D+ G + +H + G L +
Sbjct: 185 NKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKI 244
Query: 95 EHGADVNVP 103
AD+ P
Sbjct: 245 SQDADLKTP 253
>gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens]
Length = 972
Score = 67.8 bits (164), Expect = 4e-12
Identities = 49/146 (33%), Positives = 77/146 (52%), Gaps = 3/146 (2%)
Query: 15 AAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALELLKQGASPNVQ-DTS 73
AAA+G V E R++ V A + G +AL + S + L Q P D+S
Sbjct: 52 AAAKGHV-ECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSS 110
Query: 74 GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAE-SDL 132
G + +H AA G L +++L EH + +N+ D G +P+ LAVQ GH+ + FL +D+
Sbjct: 111 GKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADV 170
Query: 133 HRRDARGLTPLELALQRGAQDLVDIL 158
+ R+ G T L LA + G+ + V+ L
Sbjct: 171 NSRNKSGRTALMLACEIGSSNAVEAL 196
Score = 60.5 bits (145), Expect = 7e-10
Identities = 40/125 (32%), Positives = 57/125 (45%), Gaps = 2/125 (1%)
Query: 39 NRFGKTALQVMMFGSTAIALELL-KQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHG 97
N+ LQ + G LL K+GAS D+ G + H AA G ++ L+V++ HG
Sbjct: 9 NKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHG 68
Query: 98 ADVNVPDGTGALPIHLAVQEG-HTAVVSFLAAESDLHRRDARGLTPLELALQRGAQDLVD 156
DV D TG +HLA + H + L ++ D+ G T L A +G V
Sbjct: 69 VDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQ 128
Query: 157 ILQGH 161
IL H
Sbjct: 129 ILCEH 133
Score = 29.3 bits (64), Expect = 1.6
Identities = 20/69 (28%), Positives = 33/69 (47%), Gaps = 4/69 (5%)
Query: 39 NRFGKTALQVMM-FGSTAIALELLKQGASPNVQDTSGTSPVHD---AARTGFLDTLKVLV 94
N+ G+TAL + GS+ L+K+GA N+ D+ G + +H + G L +
Sbjct: 174 NKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKI 233
Query: 95 EHGADVNVP 103
AD+ P
Sbjct: 234 SQDADLKTP 242
>gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens]
Length = 951
Score = 67.8 bits (164), Expect = 4e-12
Identities = 49/146 (33%), Positives = 77/146 (52%), Gaps = 3/146 (2%)
Query: 15 AAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALELLKQGASPNVQ-DTS 73
AAA+G V E R++ V A + G +AL + S + L Q P D+S
Sbjct: 60 AAAKGHV-ECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSS 118
Query: 74 GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAE-SDL 132
G + +H AA G L +++L EH + +N+ D G +P+ LAVQ GH+ + FL +D+
Sbjct: 119 GKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADV 178
Query: 133 HRRDARGLTPLELALQRGAQDLVDIL 158
+ R+ G T L LA + G+ + V+ L
Sbjct: 179 NSRNKSGRTALMLACEIGSSNAVEAL 204
Score = 60.5 bits (145), Expect = 7e-10
Identities = 40/125 (32%), Positives = 57/125 (45%), Gaps = 2/125 (1%)
Query: 39 NRFGKTALQVMMFGSTAIALELL-KQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHG 97
N+ LQ + G LL K+GAS D+ G + H AA G ++ L+V++ HG
Sbjct: 17 NKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHG 76
Query: 98 ADVNVPDGTGALPIHLAVQEG-HTAVVSFLAAESDLHRRDARGLTPLELALQRGAQDLVD 156
DV D TG +HLA + H + L ++ D+ G T L A +G V
Sbjct: 77 VDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQ 136
Query: 157 ILQGH 161
IL H
Sbjct: 137 ILCEH 141
Score = 29.3 bits (64), Expect = 1.6
Identities = 20/69 (28%), Positives = 33/69 (47%), Gaps = 4/69 (5%)
Query: 39 NRFGKTALQVMM-FGSTAIALELLKQGASPNVQDTSGTSPVHD---AARTGFLDTLKVLV 94
N+ G+TAL + GS+ L+K+GA N+ D+ G + +H + G L +
Sbjct: 182 NKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKI 241
Query: 95 EHGADVNVP 103
AD+ P
Sbjct: 242 SQDADLKTP 250
>gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 67.8 bits (164), Expect = 4e-12
Identities = 49/146 (33%), Positives = 77/146 (52%), Gaps = 3/146 (2%)
Query: 15 AAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALELLKQGASPNVQ-DTS 73
AAA+G V E R++ V A + G +AL + S + L Q P D+S
Sbjct: 60 AAAKGHV-ECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSS 118
Query: 74 GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAE-SDL 132
G + +H AA G L +++L EH + +N+ D G +P+ LAVQ GH+ + FL +D+
Sbjct: 119 GKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADV 178
Query: 133 HRRDARGLTPLELALQRGAQDLVDIL 158
+ R+ G T L LA + G+ + V+ L
Sbjct: 179 NSRNKSGRTALMLACEIGSSNAVEAL 204
Score = 60.5 bits (145), Expect = 7e-10
Identities = 40/125 (32%), Positives = 57/125 (45%), Gaps = 2/125 (1%)
Query: 39 NRFGKTALQVMMFGSTAIALELL-KQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHG 97
N+ LQ + G LL K+GAS D+ G + H AA G ++ L+V++ HG
Sbjct: 17 NKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHG 76
Query: 98 ADVNVPDGTGALPIHLAVQEG-HTAVVSFLAAESDLHRRDARGLTPLELALQRGAQDLVD 156
DV D TG +HLA + H + L ++ D+ G T L A +G V
Sbjct: 77 VDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQ 136
Query: 157 ILQGH 161
IL H
Sbjct: 137 ILCEH 141
Score = 29.3 bits (64), Expect = 1.6
Identities = 20/69 (28%), Positives = 33/69 (47%), Gaps = 4/69 (5%)
Query: 39 NRFGKTALQVMM-FGSTAIALELLKQGASPNVQDTSGTSPVHD---AARTGFLDTLKVLV 94
N+ G+TAL + GS+ L+K+GA N+ D+ G + +H + G L +
Sbjct: 182 NKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKI 241
Query: 95 EHGADVNVP 103
AD+ P
Sbjct: 242 SQDADLKTP 250
>gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 67.8 bits (164), Expect = 4e-12
Identities = 49/146 (33%), Positives = 77/146 (52%), Gaps = 3/146 (2%)
Query: 15 AAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALELLKQGASPNVQ-DTS 73
AAA+G V E R++ V A + G +AL + S + L Q P D+S
Sbjct: 60 AAAKGHV-ECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSS 118
Query: 74 GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAE-SDL 132
G + +H AA G L +++L EH + +N+ D G +P+ LAVQ GH+ + FL +D+
Sbjct: 119 GKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADV 178
Query: 133 HRRDARGLTPLELALQRGAQDLVDIL 158
+ R+ G T L LA + G+ + V+ L
Sbjct: 179 NSRNKSGRTALMLACEIGSSNAVEAL 204
Score = 60.5 bits (145), Expect = 7e-10
Identities = 40/125 (32%), Positives = 57/125 (45%), Gaps = 2/125 (1%)
Query: 39 NRFGKTALQVMMFGSTAIALELL-KQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHG 97
N+ LQ + G LL K+GAS D+ G + H AA G ++ L+V++ HG
Sbjct: 17 NKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHG 76
Query: 98 ADVNVPDGTGALPIHLAVQEG-HTAVVSFLAAESDLHRRDARGLTPLELALQRGAQDLVD 156
DV D TG +HLA + H + L ++ D+ G T L A +G V
Sbjct: 77 VDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQ 136
Query: 157 ILQGH 161
IL H
Sbjct: 137 ILCEH 141
Score = 29.3 bits (64), Expect = 1.6
Identities = 20/69 (28%), Positives = 33/69 (47%), Gaps = 4/69 (5%)
Query: 39 NRFGKTALQVMM-FGSTAIALELLKQGASPNVQDTSGTSPVHD---AARTGFLDTLKVLV 94
N+ G+TAL + GS+ L+K+GA N+ D+ G + +H + G L +
Sbjct: 182 NKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKI 241
Query: 95 EHGADVNVP 103
AD+ P
Sbjct: 242 SQDADLKTP 250
>gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 67.8 bits (164), Expect = 4e-12
Identities = 49/146 (33%), Positives = 77/146 (52%), Gaps = 3/146 (2%)
Query: 15 AAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALELLKQGASPNVQ-DTS 73
AAA+G V E R++ V A + G +AL + S + L Q P D+S
Sbjct: 60 AAAKGHV-ECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSS 118
Query: 74 GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAE-SDL 132
G + +H AA G L +++L EH + +N+ D G +P+ LAVQ GH+ + FL +D+
Sbjct: 119 GKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADV 178
Query: 133 HRRDARGLTPLELALQRGAQDLVDIL 158
+ R+ G T L LA + G+ + V+ L
Sbjct: 179 NSRNKSGRTALMLACEIGSSNAVEAL 204
Score = 60.5 bits (145), Expect = 7e-10
Identities = 40/125 (32%), Positives = 57/125 (45%), Gaps = 2/125 (1%)
Query: 39 NRFGKTALQVMMFGSTAIALELL-KQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHG 97
N+ LQ + G LL K+GAS D+ G + H AA G ++ L+V++ HG
Sbjct: 17 NKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHG 76
Query: 98 ADVNVPDGTGALPIHLAVQEG-HTAVVSFLAAESDLHRRDARGLTPLELALQRGAQDLVD 156
DV D TG +HLA + H + L ++ D+ G T L A +G V
Sbjct: 77 VDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQ 136
Query: 157 ILQGH 161
IL H
Sbjct: 137 ILCEH 141
Score = 29.3 bits (64), Expect = 1.6
Identities = 20/69 (28%), Positives = 33/69 (47%), Gaps = 4/69 (5%)
Query: 39 NRFGKTALQVMM-FGSTAIALELLKQGASPNVQDTSGTSPVHD---AARTGFLDTLKVLV 94
N+ G+TAL + GS+ L+K+GA N+ D+ G + +H + G L +
Sbjct: 182 NKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKI 241
Query: 95 EHGADVNVP 103
AD+ P
Sbjct: 242 SQDADLKTP 250
>gi|38327522 cardiac ankyrin repeat protein [Homo sapiens]
Length = 319
Score = 67.8 bits (164), Expect = 4e-12
Identities = 41/127 (32%), Positives = 71/127 (55%), Gaps = 2/127 (1%)
Query: 34 HPDALNRFGKTAL-QVMMFGSTAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKV 92
+PD + + +TAL + + G AI +L++ GA +D ++ +H A+R G LD LK+
Sbjct: 145 NPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKL 204
Query: 93 LVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFL-AAESDLHRRDARGLTPLELALQRGA 151
L+ GA ++ D + +H+AV+ GH L A E+DL+ +D G TPL A++
Sbjct: 205 LLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNR 264
Query: 152 QDLVDIL 158
++ +L
Sbjct: 265 YKMIRLL 271
Score = 50.4 bits (119), Expect = 7e-07
Identities = 36/118 (30%), Positives = 58/118 (49%), Gaps = 3/118 (2%)
Query: 16 AARGDVQEVRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQGASPNVQDTSG 74
A+RG +V +LL + A ++ TAL V + G A L+ A N +D G
Sbjct: 193 ASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREG 252
Query: 75 TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAV--QEGHTAVVSFLAAES 130
+P+HDA R +++L+ +GAD+N+ + G P+ L + Q G A+ L S
Sbjct: 253 DTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLHWQNGTKAIFDSLRENS 310
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.380
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 5,793,519
Number of Sequences: 37866
Number of extensions: 236364
Number of successful extensions: 2503
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 315
Number of HSP's successfully gapped in prelim test: 61
Number of HSP's that attempted gapping in prelim test: 572
Number of HSP's gapped (non-prelim): 1253
length of query: 166
length of database: 18,247,518
effective HSP length: 95
effective length of query: 71
effective length of database: 14,650,248
effective search space: 1040167608
effective search space used: 1040167608
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 58 (26.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.