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Search of human proteins with 4502749
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4502749 cyclin-dependent kinase inhibitor 2A isoform 1 [Homo
sapiens]
(156 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4502749 cyclin-dependent kinase inhibitor 2A isoform 1 [Homo ... 313 5e-86
gi|17981694 cyclin-dependent kinase inhibitor 2B isoform 1 [Homo... 209 8e-55
gi|98985804 cyclin-dependent kinase inhibitor 2A isoform 3 [Homo... 103 6e-23
gi|4502753 cyclin-dependent kinase inhibitor 2D [Homo sapiens] 102 2e-22
gi|17981702 cyclin-dependent kinase inhibitor 2D [Homo sapiens] 102 2e-22
gi|17981699 cyclin-dependent kinase inhibitor 2C [Homo sapiens] 93 8e-20
gi|4502751 cyclin-dependent kinase inhibitor 2C [Homo sapiens] 93 8e-20
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 67 6e-12
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 67 6e-12
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 67 6e-12
gi|92087060 ankyrin repeat and SOCS box-containing 15 [Homo sapi... 63 9e-11
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 63 1e-10
gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled... 62 2e-10
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 59 1e-09
gi|20270347 ankyrin repeat domain 54 [Homo sapiens] 59 1e-09
gi|223634006 hypothetical protein LOC441869 [Homo sapiens] 58 3e-09
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 57 6e-09
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 56 1e-08
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 54 4e-08
gi|14149716 protein phosphatase 1, regulatory subunit 12C [Homo ... 53 9e-08
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 52 2e-07
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 52 2e-07
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 52 2e-07
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 52 2e-07
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 52 2e-07
gi|215598824 ankyrin repeat and SOCS box-containing 10 isoform 2... 52 2e-07
gi|215598819 ankyrin repeat and SOCS box-containing 10 isoform 1... 52 2e-07
gi|215598806 ankyrin repeat and SOCS box-containing 10 isoform 3... 52 2e-07
gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens] 52 2e-07
gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens] 52 2e-07
>gi|4502749 cyclin-dependent kinase inhibitor 2A isoform 1 [Homo
sapiens]
Length = 156
Score = 313 bits (801), Expect = 5e-86
Identities = 156/156 (100%), Positives = 156/156 (100%)
Query: 1 MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMMGSARVA 60
MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMMGSARVA
Sbjct: 1 MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMMGSARVA 60
Query: 61 ELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEE 120
ELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEE
Sbjct: 61 ELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEE 120
Query: 121 LGHRDVARYLRAAAGGTRGSNHARIDAAEGPSDIPD 156
LGHRDVARYLRAAAGGTRGSNHARIDAAEGPSDIPD
Sbjct: 121 LGHRDVARYLRAAAGGTRGSNHARIDAAEGPSDIPD 156
>gi|17981694 cyclin-dependent kinase inhibitor 2B isoform 1 [Homo
sapiens]
Length = 138
Score = 209 bits (532), Expect = 8e-55
Identities = 110/133 (82%), Positives = 114/133 (85%), Gaps = 4/133 (3%)
Query: 3 PAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMMGSARVAEL 62
P+ G S E LA+AAARG VE+VR LLEAGA PN N +GRR IQVMMMGSARVAEL
Sbjct: 9 PSGGGSDEG----LASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMMGSARVAEL 64
Query: 63 LLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELG 122
LLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEE G
Sbjct: 65 LLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERG 124
Query: 123 HRDVARYLRAAAG 135
HRDVA YLR A G
Sbjct: 125 HRDVAGYLRTATG 137
>gi|98985804 cyclin-dependent kinase inhibitor 2A isoform 3 [Homo
sapiens]
Length = 116
Score = 103 bits (257), Expect = 6e-23
Identities = 51/51 (100%), Positives = 51/51 (100%)
Query: 1 MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQV 51
MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQV
Sbjct: 1 MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQV 51
>gi|4502753 cyclin-dependent kinase inhibitor 2D [Homo sapiens]
Length = 166
Score = 102 bits (253), Expect = 2e-22
Identities = 66/150 (44%), Positives = 84/150 (56%), Gaps = 6/150 (4%)
Query: 12 SADWLATAAARGRVEEVRALLEAGAL-PNAPNSYGRRPIQVMMMGSARVAELLLLHGAEP 70
+ D L+ AAARG V+EVR LL + P+A N +G+ +QVMM GS +A LL GA P
Sbjct: 8 AGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALELLKQGASP 67
Query: 71 NCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL 130
N D + T PVHDAAR GFLDTL VL GA ++V D G LP+ LA + GH V +L
Sbjct: 68 NVQDTSG-TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFL 126
Query: 131 RAAAG----GTRGSNHARIDAAEGPSDIPD 156
A + RG + G D+ D
Sbjct: 127 AAESDLHRRDARGLTPLELALQRGAQDLVD 156
>gi|17981702 cyclin-dependent kinase inhibitor 2D [Homo sapiens]
Length = 166
Score = 102 bits (253), Expect = 2e-22
Identities = 66/150 (44%), Positives = 84/150 (56%), Gaps = 6/150 (4%)
Query: 12 SADWLATAAARGRVEEVRALLEAGAL-PNAPNSYGRRPIQVMMMGSARVAELLLLHGAEP 70
+ D L+ AAARG V+EVR LL + P+A N +G+ +QVMM GS +A LL GA P
Sbjct: 8 AGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALELLKQGASP 67
Query: 71 NCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL 130
N D + T PVHDAAR GFLDTL VL GA ++V D G LP+ LA + GH V +L
Sbjct: 68 NVQDTSG-TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFL 126
Query: 131 RAAAG----GTRGSNHARIDAAEGPSDIPD 156
A + RG + G D+ D
Sbjct: 127 AAESDLHRRDARGLTPLELALQRGAQDLVD 156
>gi|17981699 cyclin-dependent kinase inhibitor 2C [Homo sapiens]
Length = 168
Score = 93.2 bits (230), Expect = 8e-20
Identities = 56/139 (40%), Positives = 78/139 (56%), Gaps = 1/139 (0%)
Query: 10 EPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMMGSARVAELLLLHGAE 69
EP + LA+AAARG +E++ +LL+ NA N +GR +QVM +G+ +A LLL GA
Sbjct: 3 EPWGNELASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLGNPEIARRLLLRGAN 62
Query: 70 PNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARY 129
P+ D T +HDAAR GFLDTL L A +++ D G LP+ LA + GH V +
Sbjct: 63 PDLKD-RTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEF 121
Query: 130 LRAAAGGTRGSNHARIDAA 148
L G + + D A
Sbjct: 122 LVKHTASNVGHRNHKGDTA 140
>gi|4502751 cyclin-dependent kinase inhibitor 2C [Homo sapiens]
Length = 168
Score = 93.2 bits (230), Expect = 8e-20
Identities = 56/139 (40%), Positives = 78/139 (56%), Gaps = 1/139 (0%)
Query: 10 EPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMMGSARVAELLLLHGAE 69
EP + LA+AAARG +E++ +LL+ NA N +GR +QVM +G+ +A LLL GA
Sbjct: 3 EPWGNELASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLGNPEIARRLLLRGAN 62
Query: 70 PNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARY 129
P+ D T +HDAAR GFLDTL L A +++ D G LP+ LA + GH V +
Sbjct: 63 PDLKD-RTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEF 121
Query: 130 LRAAAGGTRGSNHARIDAA 148
L G + + D A
Sbjct: 122 LVKHTASNVGHRNHKGDTA 140
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 67.0 bits (162), Expect = 6e-12
Identities = 49/129 (37%), Positives = 67/129 (51%), Gaps = 4/129 (3%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMM-MGSARVAELLLLHGAEPNCAD 74
L AA G+VE VR LL GAL +A + P+ + +G + +LLL H A P+ A
Sbjct: 447 LHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAAT 506
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL--RA 132
T P+H +AREG +D VL AGA + G P+ +A + G DVA+ L R
Sbjct: 507 TNGYT-PLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRR 565
Query: 133 AAGGTRGSN 141
AA + G N
Sbjct: 566 AAADSAGKN 574
Score = 43.9 bits (102), Expect = 6e-05
Identities = 34/116 (29%), Positives = 53/116 (45%), Gaps = 2/116 (1%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMM-MGSARVAELLLLHGAEPNCAD 74
L AA G ++ + LL+ A ++ G P+ V + +VA LLL GA P+
Sbjct: 546 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 605
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL 130
T P+H AA++ + L GA ++ G P+ LA + GH D+ L
Sbjct: 606 KNGYT-PLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLL 660
Score = 43.1 bits (100), Expect = 9e-05
Identities = 38/128 (29%), Positives = 58/128 (45%), Gaps = 2/128 (1%)
Query: 4 AAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMM-GSARVAEL 62
AA S+ + L AA + LLE GA P+A G P+ + ++A
Sbjct: 567 AADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIAST 626
Query: 63 LLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELG 122
LL +GAE N +T P+H A++EG D + +L GA + + G + LA +
Sbjct: 627 LLNYGAETNIVTKQGVT-PLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQED 685
Query: 123 HRDVARYL 130
+VA L
Sbjct: 686 KVNVADIL 693
Score = 41.2 bits (95), Expect = 4e-04
Identities = 34/117 (29%), Positives = 53/117 (45%), Gaps = 2/117 (1%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMM-MGSARVAELLLLHGAEPNCAD 74
L AA +V L + GA +A G P+ V G+ ++ LL GA N
Sbjct: 678 LHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKT 737
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYLR 131
T P+H AA++G + VL + GA+ + A G + +A+ LG+ V L+
Sbjct: 738 KNGYT-PLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLK 793
Score = 38.9 bits (89), Expect = 0.002
Identities = 35/116 (30%), Positives = 51/116 (43%), Gaps = 2/116 (1%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMM-GSARVAELLLLHGAEPNCAD 74
L AA G V LL GA + G P+ V G+ + +LLL G + +
Sbjct: 216 LHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKT 275
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL 130
LT P+H AAR G + +L GA L R G P+ +A + H + ++L
Sbjct: 276 RDGLT-PLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHL 330
Score = 35.8 bits (81), Expect = 0.015
Identities = 30/113 (26%), Positives = 52/113 (46%), Gaps = 2/113 (1%)
Query: 19 AAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMM-GSARVAELLLLHGAEPNCADPAT 77
AA G +++V L+ G N N G + + G + + LL G+ + A
Sbjct: 17 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 76
Query: 78 LTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL 130
T +H A+ G + + VL + GA ++ + G P+ +A + H DV +YL
Sbjct: 77 NTA-LHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 128
Score = 31.6 bits (70), Expect = 0.29
Identities = 33/116 (28%), Positives = 49/116 (42%), Gaps = 2/116 (1%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQ-VMMMGSARVAELLLLHGAEPNCAD 74
L A+ RG V+ LL+ G +A G P+ G +V ELLL GA P A
Sbjct: 249 LHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGA-PLLAR 307
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL 130
P+H AA+ ++ + L + A +D + +A GH V + L
Sbjct: 308 TKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLL 363
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 67.0 bits (162), Expect = 6e-12
Identities = 49/129 (37%), Positives = 67/129 (51%), Gaps = 4/129 (3%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMM-MGSARVAELLLLHGAEPNCAD 74
L AA G+VE VR LL GAL +A + P+ + +G + +LLL H A P+ A
Sbjct: 468 LHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAAT 527
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL--RA 132
T P+H +AREG +D VL AGA + G P+ +A + G DVA+ L R
Sbjct: 528 TNGYT-PLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRR 586
Query: 133 AAGGTRGSN 141
AA + G N
Sbjct: 587 AAADSAGKN 595
Score = 43.9 bits (102), Expect = 6e-05
Identities = 34/116 (29%), Positives = 53/116 (45%), Gaps = 2/116 (1%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMM-MGSARVAELLLLHGAEPNCAD 74
L AA G ++ + LL+ A ++ G P+ V + +VA LLL GA P+
Sbjct: 567 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 626
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL 130
T P+H AA++ + L GA ++ G P+ LA + GH D+ L
Sbjct: 627 KNGYT-PLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLL 681
Score = 43.1 bits (100), Expect = 9e-05
Identities = 38/128 (29%), Positives = 58/128 (45%), Gaps = 2/128 (1%)
Query: 4 AAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMM-GSARVAEL 62
AA S+ + L AA + LLE GA P+A G P+ + ++A
Sbjct: 588 AADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIAST 647
Query: 63 LLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELG 122
LL +GAE N +T P+H A++EG D + +L GA + + G + LA +
Sbjct: 648 LLNYGAETNIVTKQGVT-PLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQED 706
Query: 123 HRDVARYL 130
+VA L
Sbjct: 707 KVNVADIL 714
Score = 41.2 bits (95), Expect = 4e-04
Identities = 34/117 (29%), Positives = 53/117 (45%), Gaps = 2/117 (1%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMM-MGSARVAELLLLHGAEPNCAD 74
L AA +V L + GA +A G P+ V G+ ++ LL GA N
Sbjct: 699 LHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKT 758
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYLR 131
T P+H AA++G + VL + GA+ + A G + +A+ LG+ V L+
Sbjct: 759 KNGYT-PLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLK 814
Score = 38.9 bits (89), Expect = 0.002
Identities = 35/116 (30%), Positives = 51/116 (43%), Gaps = 2/116 (1%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMM-GSARVAELLLLHGAEPNCAD 74
L AA G V LL GA + G P+ V G+ + +LLL G + +
Sbjct: 237 LHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKT 296
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL 130
LT P+H AAR G + +L GA L R G P+ +A + H + ++L
Sbjct: 297 RDGLT-PLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHL 351
Score = 35.8 bits (81), Expect = 0.015
Identities = 30/113 (26%), Positives = 52/113 (46%), Gaps = 2/113 (1%)
Query: 19 AAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMM-GSARVAELLLLHGAEPNCADPAT 77
AA G +++V L+ G N N G + + G + + LL G+ + A
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
Query: 78 LTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL 130
T +H A+ G + + VL + GA ++ + G P+ +A + H DV +YL
Sbjct: 98 NTA-LHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 149
Score = 31.6 bits (70), Expect = 0.29
Identities = 33/116 (28%), Positives = 49/116 (42%), Gaps = 2/116 (1%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQ-VMMMGSARVAELLLLHGAEPNCAD 74
L A+ RG V+ LL+ G +A G P+ G +V ELLL GA P A
Sbjct: 270 LHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGA-PLLAR 328
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL 130
P+H AA+ ++ + L + A +D + +A GH V + L
Sbjct: 329 TKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLL 384
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 67.0 bits (162), Expect = 6e-12
Identities = 49/129 (37%), Positives = 67/129 (51%), Gaps = 4/129 (3%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMM-MGSARVAELLLLHGAEPNCAD 74
L AA G+VE VR LL GAL +A + P+ + +G + +LLL H A P+ A
Sbjct: 468 LHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAAT 527
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL--RA 132
T P+H +AREG +D VL AGA + G P+ +A + G DVA+ L R
Sbjct: 528 TNGYT-PLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRR 586
Query: 133 AAGGTRGSN 141
AA + G N
Sbjct: 587 AAADSAGKN 595
Score = 43.9 bits (102), Expect = 6e-05
Identities = 34/116 (29%), Positives = 53/116 (45%), Gaps = 2/116 (1%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMM-MGSARVAELLLLHGAEPNCAD 74
L AA G ++ + LL+ A ++ G P+ V + +VA LLL GA P+
Sbjct: 567 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 626
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL 130
T P+H AA++ + L GA ++ G P+ LA + GH D+ L
Sbjct: 627 KNGYT-PLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLL 681
Score = 43.1 bits (100), Expect = 9e-05
Identities = 38/128 (29%), Positives = 58/128 (45%), Gaps = 2/128 (1%)
Query: 4 AAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMM-GSARVAEL 62
AA S+ + L AA + LLE GA P+A G P+ + ++A
Sbjct: 588 AADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIAST 647
Query: 63 LLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELG 122
LL +GAE N +T P+H A++EG D + +L GA + + G + LA +
Sbjct: 648 LLNYGAETNIVTKQGVT-PLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQED 706
Query: 123 HRDVARYL 130
+VA L
Sbjct: 707 KVNVADIL 714
Score = 41.2 bits (95), Expect = 4e-04
Identities = 34/117 (29%), Positives = 53/117 (45%), Gaps = 2/117 (1%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMM-MGSARVAELLLLHGAEPNCAD 74
L AA +V L + GA +A G P+ V G+ ++ LL GA N
Sbjct: 699 LHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKT 758
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYLR 131
T P+H AA++G + VL + GA+ + A G + +A+ LG+ V L+
Sbjct: 759 KNGYT-PLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLK 814
Score = 38.9 bits (89), Expect = 0.002
Identities = 35/116 (30%), Positives = 51/116 (43%), Gaps = 2/116 (1%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMM-GSARVAELLLLHGAEPNCAD 74
L AA G V LL GA + G P+ V G+ + +LLL G + +
Sbjct: 237 LHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKT 296
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL 130
LT P+H AAR G + +L GA L R G P+ +A + H + ++L
Sbjct: 297 RDGLT-PLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHL 351
Score = 35.8 bits (81), Expect = 0.015
Identities = 30/113 (26%), Positives = 52/113 (46%), Gaps = 2/113 (1%)
Query: 19 AAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMM-GSARVAELLLLHGAEPNCADPAT 77
AA G +++V L+ G N N G + + G + + LL G+ + A
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
Query: 78 LTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL 130
T +H A+ G + + VL + GA ++ + G P+ +A + H DV +YL
Sbjct: 98 NTA-LHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 149
Score = 31.6 bits (70), Expect = 0.29
Identities = 33/116 (28%), Positives = 49/116 (42%), Gaps = 2/116 (1%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQ-VMMMGSARVAELLLLHGAEPNCAD 74
L A+ RG V+ LL+ G +A G P+ G +V ELLL GA P A
Sbjct: 270 LHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGA-PLLAR 328
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL 130
P+H AA+ ++ + L + A +D + +A GH V + L
Sbjct: 329 TKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLL 384
>gi|92087060 ankyrin repeat and SOCS box-containing 15 [Homo
sapiens]
Length = 588
Score = 63.2 bits (152), Expect = 9e-11
Identities = 40/118 (33%), Positives = 59/118 (50%), Gaps = 6/118 (5%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMM-GSARVAELLLLHGAEPNCAD 74
L A G VE VR LLE G PN N G P+ + + GS + L+ H D
Sbjct: 115 LTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTS---LD 171
Query: 75 PATLTR--PVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL 130
+ R +H+AA++G D + +L + G + +RD +G P+ +A E GH DV +L
Sbjct: 172 QPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHL 229
Score = 30.8 bits (68), Expect = 0.49
Identities = 33/115 (28%), Positives = 52/115 (45%), Gaps = 6/115 (5%)
Query: 19 AAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMM-MGSARVAELLLLHGAEPNCA--DP 75
AA +GR + V LL+ G + + +G P+ V G V E L+ G + D
Sbjct: 184 AAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDG 243
Query: 76 ATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL 130
A++ + +AA G D + +L G +V + G LP+ A GH +YL
Sbjct: 244 ASV---LFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYL 295
Score = 30.4 bits (67), Expect = 0.64
Identities = 24/77 (31%), Positives = 31/77 (40%), Gaps = 1/77 (1%)
Query: 10 EPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMMGSARVAELLLLHGAE 69
+ A L AA G + + LLE G N PN G PI +A L+
Sbjct: 241 DDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTS 300
Query: 70 PNCADPATLTRPVHDAA 86
N + LT P+H AA
Sbjct: 301 KNAIRKSGLT-PIHSAA 316
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 62.8 bits (151), Expect = 1e-10
Identities = 41/102 (40%), Positives = 56/102 (54%), Gaps = 2/102 (1%)
Query: 19 AAARGRVEEVRALLEAGALPNAPNSYGRRPIQ-VMMMGSARVAELLLLHGAEPNCADPAT 77
AA GR + V LL+ GA A + G P+ G A V LLL HGA+PN D
Sbjct: 65 AAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWN 124
Query: 78 LTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAE 119
T P+H+AA +G +D +VL + GA +R+ GR +DLA+
Sbjct: 125 YT-PLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLAD 165
Score = 52.0 bits (123), Expect = 2e-07
Identities = 42/117 (35%), Positives = 59/117 (50%), Gaps = 3/117 (2%)
Query: 19 AAARGRVEEVRALLEAGALPNAPNSYGRRPIQ-VMMMGSARVAELLLLHGAEPNCADPAT 77
AA RV V LL+ GA +A + G P+ G VAELL+ HGA N AD
Sbjct: 533 AAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWK 592
Query: 78 LTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYLRAAA 134
T P+H+AA +G + +L + GA ++ G P+DL ++ G D+ LR A
Sbjct: 593 FT-PLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKD-GDTDIQDLLRGDA 647
Score = 48.5 bits (114), Expect = 2e-06
Identities = 40/126 (31%), Positives = 59/126 (46%), Gaps = 5/126 (3%)
Query: 4 AAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMM---MGSARVA 60
AA ++EP+A L A G VE V+ L+ + N+ ++ GR+ + G V
Sbjct: 16 AAAEAVEPAARELFEACRNGDVERVKRLVTPEKV-NSRDTAGRKSTPLHFAAGFGRKDVV 74
Query: 61 ELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEE 120
E LL +GA D L P+H+A G + + +L R GA + RD W P+ A
Sbjct: 75 EYLLQNGANVQARDDGGLI-PLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAI 133
Query: 121 LGHRDV 126
G DV
Sbjct: 134 KGKIDV 139
Score = 48.5 bits (114), Expect = 2e-06
Identities = 40/136 (29%), Positives = 61/136 (44%), Gaps = 21/136 (15%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMMGSARVAELL-----LLHGAEP 70
L AAA+G+ E + LL+ GA P N G P+ ++ G + +LL LL A+
Sbjct: 596 LHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKK 655
Query: 71 NC-------ADPATL---------TRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLP 114
C + P + + P+H AA L+ L + GA ++ +D G +P
Sbjct: 656 GCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIP 715
Query: 115 VDLAEELGHRDVARYL 130
+ A GH DVA L
Sbjct: 716 LHNAASYGHVDVAALL 731
Score = 45.4 bits (106), Expect = 2e-05
Identities = 35/120 (29%), Positives = 55/120 (45%), Gaps = 5/120 (4%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMMG---SARVAELLLLHGAEPNC 72
L AA +G + V+ L + N ++ GR + + + VAE LL HGA+ N
Sbjct: 649 LLDAAKKGCLARVKKLSSPDNV-NCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNA 707
Query: 73 ADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYLRA 132
D L P+H+AA G +D +L + A ++ D W P+ A + G + L A
Sbjct: 708 QDKGGLI-PLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLA 766
Score = 43.1 bits (100), Expect = 9e-05
Identities = 38/119 (31%), Positives = 56/119 (47%), Gaps = 5/119 (4%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQ-VMMMGSARVAELLLLHGAEPNCAD 74
L AA +E LL+ GA NA + G P+ G VA LL+ + A N D
Sbjct: 683 LHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATD 742
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYLRAA 133
T P+H+AA++G +L GA +++ G+ P+DL + DV+ L AA
Sbjct: 743 KWAFT-PLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDL---VSADDVSALLTAA 797
Score = 42.0 bits (97), Expect = 2e-04
Identities = 34/118 (28%), Positives = 53/118 (44%), Gaps = 5/118 (4%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMMGS---ARVAELLLLHGAEPNC 72
L AA G VE V+ L ++ N + GR+ + V E LL HGA+ +
Sbjct: 496 LLEAAKAGDVETVKKLCTVQSV-NCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHA 554
Query: 73 ADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL 130
D L P+H+A G + +L + GA ++V D W P+ A G ++ + L
Sbjct: 555 KDKGGLV-PLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLL 611
Score = 40.4 bits (93), Expect = 6e-04
Identities = 34/124 (27%), Positives = 55/124 (44%), Gaps = 5/124 (4%)
Query: 10 EPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMMGS---ARVAELLLLH 66
E D L +A G E++ ALL + N S GR+ + + ++ +LLL H
Sbjct: 175 EYKKDELLESARSGNEEKMMALLTPLNV-NCHASDGRKSTPLHLAAGYNRVKIVQLLLQH 233
Query: 67 GAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDV 126
GA+ + D L P+H+A G + +L + GA ++ D W P+ A +V
Sbjct: 234 GADVHAKDKGDLV-PLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEV 292
Query: 127 ARYL 130
L
Sbjct: 293 CSLL 296
>gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 2 [Homo sapiens]
Length = 1990
Score = 62.4 bits (150), Expect = 2e-10
Identities = 45/116 (38%), Positives = 58/116 (50%), Gaps = 2/116 (1%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPI-QVMMMGSARVAELLLLHGAEPNCAD 74
L AA RG++E R LLE GA PN G P+ + G ++ +LLL HGA+ N AD
Sbjct: 1038 LTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMAD 1097
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL 130
T P+ AA EG L T+ L GA + + D G + A GH V R L
Sbjct: 1098 KQGRT-PLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSL 1152
Score = 35.4 bits (80), Expect = 0.020
Identities = 24/77 (31%), Positives = 41/77 (53%), Gaps = 1/77 (1%)
Query: 54 MGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRL 113
+G + LLL GA + + + LT P+ AA G+L +V+L + A++D D G+
Sbjct: 895 LGYTEMVALLLEFGANVDASSESGLT-PLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQC 953
Query: 114 PVDLAEELGHRDVARYL 130
+ A GH +V ++L
Sbjct: 954 ALVHAALRGHLEVVKFL 970
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 59.3 bits (142), Expect = 1e-09
Identities = 39/102 (38%), Positives = 57/102 (55%), Gaps = 2/102 (1%)
Query: 19 AAARGRVEEVRALLEAGALPNAPNSYGRRPIQ-VMMMGSARVAELLLLHGAEPNCADPAT 77
AA GR + V LL+ GA +A + G P+ G A V LLL GA+PN D
Sbjct: 223 AAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWN 282
Query: 78 LTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAE 119
T P+H+AA +G +D +VL + GA ++R+ G+ +DLA+
Sbjct: 283 YT-PLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLAD 323
Score = 53.5 bits (127), Expect = 7e-08
Identities = 43/117 (36%), Positives = 58/117 (49%), Gaps = 3/117 (2%)
Query: 19 AAARGRVEEVRALLEAGALPNAPNSYGRRPIQ-VMMMGSARVAELLLLHGAEPNCADPAT 77
AA RV V LL GA +A + G P+ G VAELL+ HGA N AD
Sbjct: 691 AAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWK 750
Query: 78 LTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYLRAAA 134
T P+H+AA +G + +L + GA ++ G P+DL +E G D+ LR A
Sbjct: 751 FT-PLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKE-GDTDIQDLLRGDA 805
Score = 48.1 bits (113), Expect = 3e-06
Identities = 42/150 (28%), Positives = 65/150 (43%), Gaps = 25/150 (16%)
Query: 6 GSSMEPSADWLAT----AAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMMGSARVAE 61
G+S+ + W T AAA+G+ E + LL+ GA P N G P+ ++ G + +
Sbjct: 740 GASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQD 799
Query: 62 LL-----LLHGAEPNC-------ADPATL---------TRPVHDAAREGFLDTLVVLHRA 100
LL LL A+ C P + + P+H AA L+ L
Sbjct: 800 LLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEH 859
Query: 101 GARLDVRDAWGRLPVDLAEELGHRDVARYL 130
GA ++ +D G +P+ A GH D+A L
Sbjct: 860 GADVNAQDKGGLIPLHNAASYGHVDIAALL 889
Score = 43.5 bits (101), Expect = 7e-05
Identities = 36/104 (34%), Positives = 51/104 (49%), Gaps = 2/104 (1%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQ-VMMMGSARVAELLLLHGAEPNCAD 74
L AA RV V+ LL+ GA +A + G P+ G V ELLL HGA N D
Sbjct: 373 LHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMD 432
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLA 118
T P+H+AA + ++ +L GA + + G+ VD+A
Sbjct: 433 LWQFT-PLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMA 475
Score = 42.7 bits (99), Expect = 1e-04
Identities = 34/120 (28%), Positives = 54/120 (45%), Gaps = 5/120 (4%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMMG---SARVAELLLLHGAEPNC 72
L AA +G + V+ L + N ++ GR + + + VAE LL HGA+ N
Sbjct: 807 LLDAAKKGCLARVQKLCTPENI-NCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNA 865
Query: 73 ADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYLRA 132
D L P+H+AA G +D +L + ++ D W P+ A + G + L A
Sbjct: 866 QDKGGLI-PLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLA 924
Score = 42.7 bits (99), Expect = 1e-04
Identities = 33/104 (31%), Positives = 49/104 (47%), Gaps = 2/104 (1%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQ-VMMMGSARVAELLLLHGAEPNCAD 74
L AA +E LLE GA NA + G P+ G +A LL+ + N D
Sbjct: 841 LHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATD 900
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLA 118
T P+H+AA++G +L GA +++ G+ P+DLA
Sbjct: 901 KWAFT-PLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLA 943
Score = 42.4 bits (98), Expect = 2e-04
Identities = 36/124 (29%), Positives = 55/124 (44%), Gaps = 5/124 (4%)
Query: 10 EPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMMGS---ARVAELLLLH 66
E D L AA G E++ ALL + N S GR+ + + R+ +LLL H
Sbjct: 333 EYKKDELLEAARSGNEEKLMALLTPLNV-NCHASDGRKSTPLHLAAGYNRVRIVQLLLQH 391
Query: 67 GAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDV 126
GA+ + D L P+H+A G + +L + GA ++ D W P+ A +V
Sbjct: 392 GADVHAKDKGGLV-PLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEV 450
Query: 127 ARYL 130
L
Sbjct: 451 CSLL 454
Score = 42.0 bits (97), Expect = 2e-04
Identities = 26/73 (35%), Positives = 37/73 (50%), Gaps = 1/73 (1%)
Query: 58 RVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDL 117
+V ELLL GA N + +T P+H AA D + VLH+ GA+++ D G+ +
Sbjct: 539 QVTELLLRKGANVNEKNKDFMT-PLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHR 597
Query: 118 AEELGHRDVARYL 130
A GH R L
Sbjct: 598 AALAGHLQTCRLL 610
Score = 41.6 bits (96), Expect = 3e-04
Identities = 33/102 (32%), Positives = 47/102 (46%), Gaps = 5/102 (4%)
Query: 59 VAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLA 118
V E LL HGA+ + D L P+H+A G + +L R GA ++V D W P+ A
Sbjct: 699 VVEYLLHHGADVHAKDKGGLV-PLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEA 757
Query: 119 EELGHRDVAR-YLRAAAGGT---RGSNHARIDAAEGPSDIPD 156
G ++ + L+ A T R N EG +DI D
Sbjct: 758 AAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQD 799
Score = 38.5 bits (88), Expect = 0.002
Identities = 35/114 (30%), Positives = 50/114 (43%), Gaps = 5/114 (4%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMM---MGSARVAELLLLHGAEPNC 72
L A G V V+ L++A + NA + GR+ + G V E LL GA +
Sbjct: 186 LLEACRNGDVSRVKRLVDAANV-NAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHA 244
Query: 73 ADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDV 126
D L P+H+A G + + +L GA + RD W P+ A G DV
Sbjct: 245 RDDGGLI-PLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDV 297
Score = 37.7 bits (86), Expect = 0.004
Identities = 36/136 (26%), Positives = 59/136 (43%), Gaps = 21/136 (15%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPI-------QVMMMGSARVAELL----- 63
L AA +G+++ LL+ GA PN N+ G+ + + ++ G + ELL
Sbjct: 286 LHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARS 345
Query: 64 --------LLHGAEPNC-ADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLP 114
LL NC A + P+H AA + + +L + GA + +D G +P
Sbjct: 346 GNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVP 405
Query: 115 VDLAEELGHRDVARYL 130
+ A GH +V L
Sbjct: 406 LHNACSYGHYEVTELL 421
Score = 32.3 bits (72), Expect = 0.17
Identities = 23/68 (33%), Positives = 32/68 (47%), Gaps = 1/68 (1%)
Query: 64 LLHGAEPNCADPA-TLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELG 122
L+ A N D A + P+H AA G D + L + GA + RD G +P+ A G
Sbjct: 201 LVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFG 260
Query: 123 HRDVARYL 130
H +V L
Sbjct: 261 HAEVVSLL 268
>gi|20270347 ankyrin repeat domain 54 [Homo sapiens]
Length = 300
Score = 59.3 bits (142), Expect = 1e-09
Identities = 41/105 (39%), Positives = 56/105 (53%), Gaps = 2/105 (1%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMM-GSARVAELLLLHGAEPNCAD 74
L +A VE V+ LLE GA P A + GR + G+ ++ +LLL HGA+PN D
Sbjct: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAE 119
T P+H AA + + L R GAR+D D GR P+ LA+
Sbjct: 174 GLGNT-PLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAK 217
>gi|223634006 hypothetical protein LOC441869 [Homo sapiens]
Length = 399
Score = 58.2 bits (139), Expect = 3e-09
Identities = 43/146 (29%), Positives = 69/146 (47%), Gaps = 6/146 (4%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPI-QVMMMGSARVAELLLLHGAEPNCAD 74
L AAA GR +++ LL GA P + +GR + + G +LL+ GAE + D
Sbjct: 240 LGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARD 299
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYLRAAA 134
LT P+H A+REG ++ L GA++D + P+ LA E GH L +
Sbjct: 300 TLGLT-PLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRG 358
Query: 135 GG----TRGSNHARIDAAEGPSDIPD 156
T+ + A++ + P +P+
Sbjct: 359 ASPTLRTQWAEVAQMPEGDLPQALPE 384
Score = 53.5 bits (127), Expect = 7e-08
Identities = 40/113 (35%), Positives = 57/113 (50%), Gaps = 2/113 (1%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMM-MGSARVAELLLLHGAEPNCAD 74
L AAA GR +R LL GA +A + G + + +G ++ E+LL HGA+P D
Sbjct: 207 LLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRD 266
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVA 127
+ +H AA G L + +L GA +D RD G P+ A GH +VA
Sbjct: 267 RHGRSA-LHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVA 318
Score = 46.6 bits (109), Expect = 9e-06
Identities = 42/131 (32%), Positives = 55/131 (41%), Gaps = 2/131 (1%)
Query: 6 GSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMM-GSARVAELLL 64
G S+ L A RG V LL GA + GR P+ + ++ G A + LLL
Sbjct: 35 GPSVVQGWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLL 94
Query: 65 LHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHR 124
GA D A T +H+AA G +L + GA R G P+ A LGH
Sbjct: 95 QRGAPVGAVDRAGRTA-LHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHT 153
Query: 125 DVARYLRAAAG 135
+A L A G
Sbjct: 154 LLAARLLEAPG 164
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 57.0 bits (136), Expect = 6e-09
Identities = 50/145 (34%), Positives = 64/145 (44%), Gaps = 7/145 (4%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMM-MGSARVAELLLLHGAEPNCAD 74
L AA+ G V LL GA ++ +S GR + + G+ V LL G + N D
Sbjct: 785 LLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRD 844
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL---- 130
A T P+H AA EG L GAR + D GR+P LA + GH D + L
Sbjct: 845 DAGWT-PLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENK 903
Query: 131 -RAAAGGTRGSNHARIDAAEGPSDI 154
G G N R+ A EG DI
Sbjct: 904 SNIDQRGYDGRNALRVAALEGHRDI 928
Score = 52.0 bits (123), Expect = 2e-07
Identities = 43/121 (35%), Positives = 57/121 (47%), Gaps = 7/121 (5%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMM------GSARVAELLLLHGAE 69
L AA G E V LL+ GA N + GR + V + G A V LL+ GAE
Sbjct: 681 LIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAE 740
Query: 70 PNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARY 129
+ D +T P+ AA EG +D + +L GA +D D GR P+ A +GH V
Sbjct: 741 VDHCDKDGMT-PLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNT 799
Query: 130 L 130
L
Sbjct: 800 L 800
Score = 46.6 bits (109), Expect = 9e-06
Identities = 37/116 (31%), Positives = 55/116 (47%), Gaps = 2/116 (1%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMM-GSARVAELLLLHGAEPNCAD 74
L+ A+A+G VE VR LL+ G N + G P+ + G + E L+ GA N D
Sbjct: 818 LSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEID 877
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL 130
P A++EG D + +L + +D R GR + +A GHRD+ L
Sbjct: 878 NDGRI-PFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELL 932
Score = 44.7 bits (104), Expect = 3e-05
Identities = 35/112 (31%), Positives = 57/112 (50%), Gaps = 6/112 (5%)
Query: 22 RGRVEEVRALLEAGALPNAPNSYGRRPIQ-VMMMGSARVAELLLLHGA--EPNCADPATL 78
+G +E V+ L+ A NA ++ R +Q G +V +LL+ HGA + C AT
Sbjct: 989 QGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATA 1048
Query: 79 TRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL 130
+ AA+EG +D + VL GA + D +GR + +A + GH + + L
Sbjct: 1049 ---LCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLL 1097
Score = 39.7 bits (91), Expect = 0.001
Identities = 37/132 (28%), Positives = 60/132 (45%), Gaps = 10/132 (7%)
Query: 19 AAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMM-GSARVAELLLLHGAEPNCADPAT 77
A+ G + V+ LLE + + GR ++V + G + ELL HGA+ NC D A
Sbjct: 887 ASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKD-AD 945
Query: 78 LTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYLRAAAGGT 137
++ A E L GA ++ DA GR + ++ GH ++ + L A
Sbjct: 946 GRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIA----- 1000
Query: 138 RGSNHARIDAAE 149
HA ++AA+
Sbjct: 1001 ---YHADVNAAD 1009
Score = 39.7 bits (91), Expect = 0.001
Identities = 29/88 (32%), Positives = 47/88 (53%), Gaps = 2/88 (2%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMM-GSARVAELLLLHGAEPNCAD 74
L +AA +G V+ V+ L+E GA+ + + G + + G V ++LL HGA+PN AD
Sbjct: 1016 LQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHAD 1075
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGA 102
T + AA+ G + +L + GA
Sbjct: 1076 QFGRT-AMRVAAKNGHSQIIKLLEKYGA 1102
Score = 36.2 bits (82), Expect = 0.012
Identities = 25/70 (35%), Positives = 38/70 (54%), Gaps = 6/70 (8%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMM-GSARVAELLLLHGAEP-NCA 73
L AA G ++ V+ LLE GA PN + +GR ++V G +++ +LL +GA N
Sbjct: 1049 LCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNGC 1108
Query: 74 DPATLTRPVH 83
P+ PVH
Sbjct: 1109 SPS----PVH 1114
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 56.2 bits (134), Expect = 1e-08
Identities = 40/116 (34%), Positives = 57/116 (49%), Gaps = 2/116 (1%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMM-MGSARVAELLLLHGAEPNCAD 74
L AA G+ E VR L++ GA A + P+ + +G A + + LL GA PN A
Sbjct: 470 LHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAAT 529
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL 130
+ T P+H +AREG D L GA L + G P+ +A + G +VA L
Sbjct: 530 TSGYT-PLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLL 584
Score = 50.1 bits (118), Expect = 8e-07
Identities = 41/127 (32%), Positives = 56/127 (44%), Gaps = 2/127 (1%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMM-MGSARVAELLLLHGAEPNCAD 74
L AA G++E LL+ A P+A G P+ V + +VA LLL GA P+ A
Sbjct: 569 LHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAA 628
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYLRAAA 134
T P+H AA++ +D L GA + G V LA + GH D+ L
Sbjct: 629 KNGYT-PLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRN 687
Query: 135 GGTRGSN 141
SN
Sbjct: 688 ANVNLSN 694
Score = 48.5 bits (114), Expect = 2e-06
Identities = 37/116 (31%), Positives = 54/116 (46%), Gaps = 2/116 (1%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMMGSA-RVAELLLLHGAEPNCAD 74
L AA G + + LL+ A PNA G P+ + + +V ELLL HGA
Sbjct: 371 LHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVT 430
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL 130
+ LT P+H AA G ++ + L GA + + G + +A G +V RYL
Sbjct: 431 ESGLT-PIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYL 485
Score = 48.5 bits (114), Expect = 2e-06
Identities = 39/115 (33%), Positives = 51/115 (44%), Gaps = 6/115 (5%)
Query: 19 AAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMM-GSARVAELLLLHGA--EPNCADP 75
AA G V V L+ GA PN N G + + G A V L+ GA E D
Sbjct: 440 AAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDD 499
Query: 76 ATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL 130
T P+H +AR G D + L + GA + G P+ L+ GH DVA +L
Sbjct: 500 QT---PLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFL 551
Score = 34.3 bits (77), Expect = 0.044
Identities = 29/116 (25%), Positives = 49/116 (42%), Gaps = 2/116 (1%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMM-MGSARVAELLLLHGAEPNCAD 74
L AA + + LL+ + + G P+ + G+ VA LLL A +
Sbjct: 206 LHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTA 265
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL 130
+T P+H A++ G + + +L GA++D + G P+ GH V L
Sbjct: 266 RNDIT-PLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEML 320
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 54.3 bits (129), Expect = 4e-08
Identities = 37/101 (36%), Positives = 51/101 (50%), Gaps = 2/101 (1%)
Query: 19 AAARGRVEEVRALLEAGALPNAPNSYGRRPIQ-VMMMGSARVAELLLLHGAEPNCADPAT 77
AA G E V+ LL GA NA + RR I MG V +LL+ HGAE C D +
Sbjct: 147 AAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKS 206
Query: 78 LTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLA 118
T P+H AA G + + L G ++ +A+G P+ +A
Sbjct: 207 YT-PLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVA 246
Score = 42.4 bits (98), Expect = 2e-04
Identities = 32/110 (29%), Positives = 48/110 (43%), Gaps = 3/110 (2%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMMGS--ARVAELLLLHGAEPNCA 73
L A G+ V L++ GA+ N N G P+ + A ELL+ +GA+ N
Sbjct: 243 LHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMK 302
Query: 74 DPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGH 123
T P+H A G + ++GA +D D G P+ +A GH
Sbjct: 303 SKDGKT-PLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGH 351
Score = 36.2 bits (82), Expect = 0.012
Identities = 26/82 (31%), Positives = 40/82 (48%), Gaps = 1/82 (1%)
Query: 43 SYGRRPIQVMMMGSARVAELLLLHGAEP-NCADPATLTRPVHDAAREGFLDTLVVLHRAG 101
+YG R ++ + L+ G + + +D P+H AA G L VL ++
Sbjct: 514 AYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSL 573
Query: 102 ARLDVRDAWGRLPVDLAEELGH 123
LDVR++ GR P+DLA GH
Sbjct: 574 LDLDVRNSSGRTPLDLAAFKGH 595
Score = 35.8 bits (81), Expect = 0.015
Identities = 31/119 (26%), Positives = 52/119 (43%), Gaps = 8/119 (6%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMMGSARVAELLLLHGAEPNCADP 75
L A GR + ++++GA+ + + G P+ + +AR LL++ + AD
Sbjct: 310 LHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHI----AARYGHELLINTLITSGADT 365
Query: 76 ATL----TRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL 130
A P+H AA GF D L +G +D D +GR + A G+ + L
Sbjct: 366 AKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLL 424
Score = 35.8 bits (81), Expect = 0.015
Identities = 32/114 (28%), Positives = 44/114 (38%), Gaps = 4/114 (3%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRR-PIQVMMMGSARVAELLLLHGAEPNCA- 73
L AA +G VE V L+ GA + +R PI LL+ AEP A
Sbjct: 587 LDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAV 646
Query: 74 --DPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRD 125
P+ + G D + L GA +D +D WGR + GH +
Sbjct: 647 DIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEE 700
Score = 35.0 bits (79), Expect = 0.026
Identities = 33/116 (28%), Positives = 53/116 (45%), Gaps = 2/116 (1%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMMGSA-RVAELLLLHGAEPNCAD 74
L A A E V+ LL+ A NA + + P+ + A + AE L+ + N +D
Sbjct: 78 LHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSD 137
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL 130
A T +H AA G + + +L GA ++ D R + A +GH +V + L
Sbjct: 138 RAGRTA-LHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLL 192
Score = 33.9 bits (76), Expect = 0.057
Identities = 34/120 (28%), Positives = 53/120 (44%), Gaps = 5/120 (4%)
Query: 19 AAARGRVEEVRALLEAGALPNA---PNSYGRRPIQVMMM-GSARVAELLLLHGAEPNCAD 74
AA G E +R L+ NA + G+ P+ + ++ G LL GA + D
Sbjct: 624 AATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKD 683
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYLRAAA 134
T +H A G + + L + GA+ +RD+ GR P+ L+ GH V L +A
Sbjct: 684 KWGRTA-LHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSA 742
Score = 33.5 bits (75), Expect = 0.075
Identities = 37/114 (32%), Positives = 48/114 (42%), Gaps = 9/114 (7%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMMG-SARVAELLLLHGAEPNCAD 74
L AAA G +E + LL GA N + +GR P+ + + L+ GA N D
Sbjct: 409 LHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLD 468
Query: 75 PATLTRPVHDAAREGFLDT----LVVLHRAGARLDVRDAWGRLPVDLAEELGHR 124
T P+H AA DT L L R A +RD G V + GHR
Sbjct: 469 ERGCT-PLHYAATS---DTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHR 518
Score = 33.1 bits (74), Expect = 0.098
Identities = 30/101 (29%), Positives = 45/101 (44%), Gaps = 2/101 (1%)
Query: 31 LLEAGALPNAPNSYGRRPIQVMMM-GSARVAELLLLHGAEPNCADPATLTRPVHDAAREG 89
L+ GA N + G+ P+ + + G ++ ++ GA +C D T P+H AAR G
Sbjct: 292 LVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNT-PLHIAARYG 350
Query: 90 FLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL 130
+ L +GA R G P+ LA G D R L
Sbjct: 351 HELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKL 391
Score = 28.1 bits (61), Expect = 3.2
Identities = 26/76 (34%), Positives = 34/76 (44%), Gaps = 4/76 (5%)
Query: 6 GSSMEPSADWLATAAARGRV----EEVRALLEAGALPNAPNSYGRRPIQVMMMGSARVAE 61
G++++ W TA RG V E V ALL+ GA +S GR PI +
Sbjct: 676 GANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVL 735
Query: 62 LLLLHGAEPNCADPAT 77
LL A A+PAT
Sbjct: 736 GALLQSAASMDANPAT 751
>gi|14149716 protein phosphatase 1, regulatory subunit 12C [Homo
sapiens]
Length = 782
Score = 53.1 bits (126), Expect = 9e-08
Identities = 52/185 (28%), Positives = 74/185 (40%), Gaps = 33/185 (17%)
Query: 1 MEPAAGSSMEPSADW--LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQ-------- 50
+E A + + W L AA+ G ++ R LL GA A NS G P+
Sbjct: 121 VEQGATVNQADNEGWTPLHVAASCGYLDIARYLLSHGANIAAVNSDGDLPLDLAESDAME 180
Query: 51 -----------VMMMGSARVAELLLLH--------GAEPNCADPATLTRPVHDAAREGFL 91
V + + R E LLLH GA P P T +H AA +G++
Sbjct: 181 GLLKAEIARRGVDVEAAKRAEEELLLHDTRCWLNGGAMPEARHPRTGASALHVAAAKGYI 240
Query: 92 DTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYLRAAAGGTRGSNHARIDAAEGP 151
+ + +L +AG ++RD G P+ A G D R L GG H A + P
Sbjct: 241 EVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGMDSLTH----AGQRP 296
Query: 152 SDIPD 156
D+ D
Sbjct: 297 CDLAD 301
Score = 37.7 bits (86), Expect = 0.004
Identities = 31/98 (31%), Positives = 41/98 (41%), Gaps = 3/98 (3%)
Query: 25 VEEVRALLEAGALPNA--PNSYGRRPIQVMMMGSARVAELLLLHGAEPNCADPATLTRPV 82
+ + R L GA+P A P + G V LLL G +P D T P+
Sbjct: 206 LHDTRCWLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWT-PL 264
Query: 83 HDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEE 120
H AA G D +L G +D G+ P DLA+E
Sbjct: 265 HAAAHWGVEDACRLLAEHGGGMDSLTHAGQRPCDLADE 302
Score = 33.1 bits (74), Expect = 0.098
Identities = 40/147 (27%), Positives = 59/147 (40%), Gaps = 27/147 (18%)
Query: 10 EPSADWLATAAARGRVEEVRALLEAGAL-PNAPNSYGRRPIQVMMMGSARVAELLLLHGA 68
E +A++LA A A G ++E R +L A P A P ++ S + LH A
Sbjct: 50 ERAAEFLA-ACAGGDLDEARLMLRAADPGPGAELDPAAPPPARAVLDSTNADGISALHQA 108
Query: 69 EPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVAR 128
C D L+ + L GA ++ D G P+ +A G+ D+AR
Sbjct: 109 ---CIDEN--------------LEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIAR 151
Query: 129 YLRAAAGGTRGSNHARIDAAEGPSDIP 155
YL S+ A I A D+P
Sbjct: 152 YLL--------SHGANIAAVNSDGDLP 170
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 52.4 bits (124), Expect = 2e-07
Identities = 40/132 (30%), Positives = 63/132 (47%), Gaps = 5/132 (3%)
Query: 3 PAAGSSMEPSADW---LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMM-GSAR 58
P GS P+ + L AA + +VE R+LL+ G NA + G P+ + G A
Sbjct: 623 PRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAE 682
Query: 59 VAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLA 118
+ LLL A N + + LT P+H A+EG + VL + G +D G P+ +A
Sbjct: 683 MVALLLSKQANGNLGNKSGLT-PLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVA 741
Query: 119 EELGHRDVARYL 130
G+ + ++L
Sbjct: 742 SHYGNIKLVKFL 753
Score = 50.8 bits (120), Expect = 5e-07
Identities = 39/116 (33%), Positives = 57/116 (49%), Gaps = 2/116 (1%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMMGS-ARVAELLLLHGAEPNCAD 74
L AA G + LL+ GA PN+ G P+ + + RV ELLL GA +
Sbjct: 375 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 434
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL 130
+ LT P+H A+ G L + L + GA +V + P+ +A GH +VA+YL
Sbjct: 435 ESGLT-PLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 489
Score = 47.0 bits (110), Expect = 7e-06
Identities = 39/127 (30%), Positives = 57/127 (44%), Gaps = 3/127 (2%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMM-MGSARVAELLLLHGAEPNCAD 74
L AA G+V LLE A PNA G P+ V + + + +LLL G P+
Sbjct: 573 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 632
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRD-VARYLRAA 133
T P+H AA++ ++ L + G + G P+ LA + GH + VA L
Sbjct: 633 WNGYT-PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQ 691
Query: 134 AGGTRGS 140
A G G+
Sbjct: 692 ANGNLGN 698
Score = 46.6 bits (109), Expect = 9e-06
Identities = 33/116 (28%), Positives = 55/116 (47%), Gaps = 2/116 (1%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVM-MMGSARVAELLLLHGAEPNCAD 74
L A + V + LL+ GA +A G P+ V MG + + LL GA PN ++
Sbjct: 408 LHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN 467
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL 130
T P+H AAR G + L + A+++ + + P+ A +GH ++ + L
Sbjct: 468 VKVET-PLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLL 522
Score = 46.6 bits (109), Expect = 9e-06
Identities = 42/129 (32%), Positives = 58/129 (44%), Gaps = 4/129 (3%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQ-VMMMGSARVAELLLLHGAEPNCAD 74
L AA G E + LL+ A NA + P+ +G + +LLL + A PN A
Sbjct: 474 LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT 533
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL--RA 132
A T P+H AAREG ++T++ L A G P+ +A + G VA L R
Sbjct: 534 TAGHT-PLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERD 592
Query: 133 AAGGTRGSN 141
A G N
Sbjct: 593 AHPNAAGKN 601
Score = 38.5 bits (88), Expect = 0.002
Identities = 34/116 (29%), Positives = 49/116 (42%), Gaps = 2/116 (1%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMM-GSARVAELLLLHGAEPNCAD 74
L AA + + LL GA N G P+ + G+ + LLL GA+
Sbjct: 243 LHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKT 302
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL 130
LT P+H AAR G + +L GA + + G P+ +A + H D R L
Sbjct: 303 KDELT-PLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 357
Score = 37.7 bits (86), Expect = 0.004
Identities = 39/160 (24%), Positives = 57/160 (35%), Gaps = 35/160 (21%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMMGS------------------- 56
L AA G V LL+ GA A G PI + G
Sbjct: 309 LHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDIT 368
Query: 57 ---------------ARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAG 101
RVA++LL GA+PN T P+H A ++ + + +L + G
Sbjct: 369 LDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFT-PLHIACKKNHVRVMELLLKTG 427
Query: 102 ARLDVRDAWGRLPVDLAEELGHRDVARYLRAAAGGTRGSN 141
A +D G P+ +A +GH + + L SN
Sbjct: 428 ASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN 467
Score = 33.9 bits (76), Expect = 0.057
Identities = 27/83 (32%), Positives = 39/83 (46%), Gaps = 2/83 (2%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPI-QVMMMGSARVAELLLLHGAEPNCAD 74
L A+ G ++ V+ LL+ A NA G P+ Q G + LLL +GA PN
Sbjct: 738 LHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVS 797
Query: 75 PATLTRPVHDAAREGFLDTLVVL 97
+ T P+ A R G++ VL
Sbjct: 798 -SDGTTPLAIAKRLGYISVTDVL 819
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 52.4 bits (124), Expect = 2e-07
Identities = 40/132 (30%), Positives = 63/132 (47%), Gaps = 5/132 (3%)
Query: 3 PAAGSSMEPSADW---LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMM-GSAR 58
P GS P+ + L AA + +VE R+LL+ G NA + G P+ + G A
Sbjct: 590 PRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAE 649
Query: 59 VAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLA 118
+ LLL A N + + LT P+H A+EG + VL + G +D G P+ +A
Sbjct: 650 MVALLLSKQANGNLGNKSGLT-PLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVA 708
Query: 119 EELGHRDVARYL 130
G+ + ++L
Sbjct: 709 SHYGNIKLVKFL 720
Score = 50.8 bits (120), Expect = 5e-07
Identities = 39/116 (33%), Positives = 57/116 (49%), Gaps = 2/116 (1%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMMGS-ARVAELLLLHGAEPNCAD 74
L AA G + LL+ GA PN+ G P+ + + RV ELLL GA +
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL 130
+ LT P+H A+ G L + L + GA +V + P+ +A GH +VA+YL
Sbjct: 402 ESGLT-PLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Score = 47.0 bits (110), Expect = 7e-06
Identities = 39/127 (30%), Positives = 57/127 (44%), Gaps = 3/127 (2%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMM-MGSARVAELLLLHGAEPNCAD 74
L AA G+V LLE A PNA G P+ V + + + +LLL G P+
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 599
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRD-VARYLRAA 133
T P+H AA++ ++ L + G + G P+ LA + GH + VA L
Sbjct: 600 WNGYT-PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQ 658
Query: 134 AGGTRGS 140
A G G+
Sbjct: 659 ANGNLGN 665
Score = 46.6 bits (109), Expect = 9e-06
Identities = 33/116 (28%), Positives = 55/116 (47%), Gaps = 2/116 (1%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVM-MMGSARVAELLLLHGAEPNCAD 74
L A + V + LL+ GA +A G P+ V MG + + LL GA PN ++
Sbjct: 375 LHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN 434
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL 130
T P+H AAR G + L + A+++ + + P+ A +GH ++ + L
Sbjct: 435 VKVET-PLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLL 489
Score = 46.6 bits (109), Expect = 9e-06
Identities = 42/129 (32%), Positives = 58/129 (44%), Gaps = 4/129 (3%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQ-VMMMGSARVAELLLLHGAEPNCAD 74
L AA G E + LL+ A NA + P+ +G + +LLL + A PN A
Sbjct: 441 LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT 500
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL--RA 132
A T P+H AAREG ++T++ L A G P+ +A + G VA L R
Sbjct: 501 TAGHT-PLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERD 559
Query: 133 AAGGTRGSN 141
A G N
Sbjct: 560 AHPNAAGKN 568
Score = 38.5 bits (88), Expect = 0.002
Identities = 34/116 (29%), Positives = 49/116 (42%), Gaps = 2/116 (1%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMM-GSARVAELLLLHGAEPNCAD 74
L AA + + LL GA N G P+ + G+ + LLL GA+
Sbjct: 210 LHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKT 269
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL 130
LT P+H AAR G + +L GA + + G P+ +A + H D R L
Sbjct: 270 KDELT-PLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 324
Score = 37.7 bits (86), Expect = 0.004
Identities = 39/160 (24%), Positives = 57/160 (35%), Gaps = 35/160 (21%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMMGS------------------- 56
L AA G V LL+ GA A G PI + G
Sbjct: 276 LHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDIT 335
Query: 57 ---------------ARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAG 101
RVA++LL GA+PN T P+H A ++ + + +L + G
Sbjct: 336 LDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFT-PLHIACKKNHVRVMELLLKTG 394
Query: 102 ARLDVRDAWGRLPVDLAEELGHRDVARYLRAAAGGTRGSN 141
A +D G P+ +A +GH + + L SN
Sbjct: 395 ASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN 434
Score = 33.9 bits (76), Expect = 0.057
Identities = 27/83 (32%), Positives = 39/83 (46%), Gaps = 2/83 (2%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPI-QVMMMGSARVAELLLLHGAEPNCAD 74
L A+ G ++ V+ LL+ A NA G P+ Q G + LLL +GA PN
Sbjct: 705 LHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVS 764
Query: 75 PATLTRPVHDAAREGFLDTLVVL 97
+ T P+ A R G++ VL
Sbjct: 765 -SDGTTPLAIAKRLGYISVTDVL 786
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 52.4 bits (124), Expect = 2e-07
Identities = 40/132 (30%), Positives = 63/132 (47%), Gaps = 5/132 (3%)
Query: 3 PAAGSSMEPSADW---LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMM-GSAR 58
P GS P+ + L AA + +VE R+LL+ G NA + G P+ + G A
Sbjct: 590 PRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAE 649
Query: 59 VAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLA 118
+ LLL A N + + LT P+H A+EG + VL + G +D G P+ +A
Sbjct: 650 MVALLLSKQANGNLGNKSGLT-PLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVA 708
Query: 119 EELGHRDVARYL 130
G+ + ++L
Sbjct: 709 SHYGNIKLVKFL 720
Score = 50.8 bits (120), Expect = 5e-07
Identities = 39/116 (33%), Positives = 57/116 (49%), Gaps = 2/116 (1%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMMGS-ARVAELLLLHGAEPNCAD 74
L AA G + LL+ GA PN+ G P+ + + RV ELLL GA +
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL 130
+ LT P+H A+ G L + L + GA +V + P+ +A GH +VA+YL
Sbjct: 402 ESGLT-PLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Score = 47.0 bits (110), Expect = 7e-06
Identities = 39/127 (30%), Positives = 57/127 (44%), Gaps = 3/127 (2%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMM-MGSARVAELLLLHGAEPNCAD 74
L AA G+V LLE A PNA G P+ V + + + +LLL G P+
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 599
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRD-VARYLRAA 133
T P+H AA++ ++ L + G + G P+ LA + GH + VA L
Sbjct: 600 WNGYT-PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQ 658
Query: 134 AGGTRGS 140
A G G+
Sbjct: 659 ANGNLGN 665
Score = 46.6 bits (109), Expect = 9e-06
Identities = 33/116 (28%), Positives = 55/116 (47%), Gaps = 2/116 (1%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVM-MMGSARVAELLLLHGAEPNCAD 74
L A + V + LL+ GA +A G P+ V MG + + LL GA PN ++
Sbjct: 375 LHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN 434
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL 130
T P+H AAR G + L + A+++ + + P+ A +GH ++ + L
Sbjct: 435 VKVET-PLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLL 489
Score = 46.6 bits (109), Expect = 9e-06
Identities = 42/129 (32%), Positives = 58/129 (44%), Gaps = 4/129 (3%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQ-VMMMGSARVAELLLLHGAEPNCAD 74
L AA G E + LL+ A NA + P+ +G + +LLL + A PN A
Sbjct: 441 LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT 500
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL--RA 132
A T P+H AAREG ++T++ L A G P+ +A + G VA L R
Sbjct: 501 TAGHT-PLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERD 559
Query: 133 AAGGTRGSN 141
A G N
Sbjct: 560 AHPNAAGKN 568
Score = 38.5 bits (88), Expect = 0.002
Identities = 34/116 (29%), Positives = 49/116 (42%), Gaps = 2/116 (1%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMM-GSARVAELLLLHGAEPNCAD 74
L AA + + LL GA N G P+ + G+ + LLL GA+
Sbjct: 210 LHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKT 269
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL 130
LT P+H AAR G + +L GA + + G P+ +A + H D R L
Sbjct: 270 KDELT-PLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 324
Score = 37.7 bits (86), Expect = 0.004
Identities = 39/160 (24%), Positives = 57/160 (35%), Gaps = 35/160 (21%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMMGS------------------- 56
L AA G V LL+ GA A G PI + G
Sbjct: 276 LHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDIT 335
Query: 57 ---------------ARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAG 101
RVA++LL GA+PN T P+H A ++ + + +L + G
Sbjct: 336 LDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFT-PLHIACKKNHVRVMELLLKTG 394
Query: 102 ARLDVRDAWGRLPVDLAEELGHRDVARYLRAAAGGTRGSN 141
A +D G P+ +A +GH + + L SN
Sbjct: 395 ASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN 434
Score = 33.9 bits (76), Expect = 0.057
Identities = 27/83 (32%), Positives = 39/83 (46%), Gaps = 2/83 (2%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPI-QVMMMGSARVAELLLLHGAEPNCAD 74
L A+ G ++ V+ LL+ A NA G P+ Q G + LLL +GA PN
Sbjct: 705 LHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVS 764
Query: 75 PATLTRPVHDAAREGFLDTLVVL 97
+ T P+ A R G++ VL
Sbjct: 765 -SDGTTPLAIAKRLGYISVTDVL 786
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 52.4 bits (124), Expect = 2e-07
Identities = 40/132 (30%), Positives = 63/132 (47%), Gaps = 5/132 (3%)
Query: 3 PAAGSSMEPSADW---LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMM-GSAR 58
P GS P+ + L AA + +VE R+LL+ G NA + G P+ + G A
Sbjct: 590 PRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAE 649
Query: 59 VAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLA 118
+ LLL A N + + LT P+H A+EG + VL + G +D G P+ +A
Sbjct: 650 MVALLLSKQANGNLGNKSGLT-PLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVA 708
Query: 119 EELGHRDVARYL 130
G+ + ++L
Sbjct: 709 SHYGNIKLVKFL 720
Score = 50.8 bits (120), Expect = 5e-07
Identities = 39/116 (33%), Positives = 57/116 (49%), Gaps = 2/116 (1%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMMGS-ARVAELLLLHGAEPNCAD 74
L AA G + LL+ GA PN+ G P+ + + RV ELLL GA +
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL 130
+ LT P+H A+ G L + L + GA +V + P+ +A GH +VA+YL
Sbjct: 402 ESGLT-PLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Score = 47.0 bits (110), Expect = 7e-06
Identities = 39/127 (30%), Positives = 57/127 (44%), Gaps = 3/127 (2%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMM-MGSARVAELLLLHGAEPNCAD 74
L AA G+V LLE A PNA G P+ V + + + +LLL G P+
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 599
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRD-VARYLRAA 133
T P+H AA++ ++ L + G + G P+ LA + GH + VA L
Sbjct: 600 WNGYT-PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQ 658
Query: 134 AGGTRGS 140
A G G+
Sbjct: 659 ANGNLGN 665
Score = 46.6 bits (109), Expect = 9e-06
Identities = 33/116 (28%), Positives = 55/116 (47%), Gaps = 2/116 (1%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVM-MMGSARVAELLLLHGAEPNCAD 74
L A + V + LL+ GA +A G P+ V MG + + LL GA PN ++
Sbjct: 375 LHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN 434
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL 130
T P+H AAR G + L + A+++ + + P+ A +GH ++ + L
Sbjct: 435 VKVET-PLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLL 489
Score = 46.6 bits (109), Expect = 9e-06
Identities = 42/129 (32%), Positives = 58/129 (44%), Gaps = 4/129 (3%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQ-VMMMGSARVAELLLLHGAEPNCAD 74
L AA G E + LL+ A NA + P+ +G + +LLL + A PN A
Sbjct: 441 LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT 500
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL--RA 132
A T P+H AAREG ++T++ L A G P+ +A + G VA L R
Sbjct: 501 TAGHT-PLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERD 559
Query: 133 AAGGTRGSN 141
A G N
Sbjct: 560 AHPNAAGKN 568
Score = 38.5 bits (88), Expect = 0.002
Identities = 34/116 (29%), Positives = 49/116 (42%), Gaps = 2/116 (1%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMM-GSARVAELLLLHGAEPNCAD 74
L AA + + LL GA N G P+ + G+ + LLL GA+
Sbjct: 210 LHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKT 269
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL 130
LT P+H AAR G + +L GA + + G P+ +A + H D R L
Sbjct: 270 KDELT-PLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 324
Score = 37.7 bits (86), Expect = 0.004
Identities = 39/160 (24%), Positives = 57/160 (35%), Gaps = 35/160 (21%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMMGS------------------- 56
L AA G V LL+ GA A G PI + G
Sbjct: 276 LHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDIT 335
Query: 57 ---------------ARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAG 101
RVA++LL GA+PN T P+H A ++ + + +L + G
Sbjct: 336 LDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFT-PLHIACKKNHVRVMELLLKTG 394
Query: 102 ARLDVRDAWGRLPVDLAEELGHRDVARYLRAAAGGTRGSN 141
A +D G P+ +A +GH + + L SN
Sbjct: 395 ASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN 434
Score = 33.9 bits (76), Expect = 0.057
Identities = 27/83 (32%), Positives = 39/83 (46%), Gaps = 2/83 (2%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPI-QVMMMGSARVAELLLLHGAEPNCAD 74
L A+ G ++ V+ LL+ A NA G P+ Q G + LLL +GA PN
Sbjct: 705 LHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVS 764
Query: 75 PATLTRPVHDAAREGFLDTLVVL 97
+ T P+ A R G++ VL
Sbjct: 765 -SDGTTPLAIAKRLGYISVTDVL 786
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 52.4 bits (124), Expect = 2e-07
Identities = 40/132 (30%), Positives = 63/132 (47%), Gaps = 5/132 (3%)
Query: 3 PAAGSSMEPSADW---LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMM-GSAR 58
P GS P+ + L AA + +VE R+LL+ G NA + G P+ + G A
Sbjct: 590 PRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAE 649
Query: 59 VAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLA 118
+ LLL A N + + LT P+H A+EG + VL + G +D G P+ +A
Sbjct: 650 MVALLLSKQANGNLGNKSGLT-PLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVA 708
Query: 119 EELGHRDVARYL 130
G+ + ++L
Sbjct: 709 SHYGNIKLVKFL 720
Score = 50.8 bits (120), Expect = 5e-07
Identities = 39/116 (33%), Positives = 57/116 (49%), Gaps = 2/116 (1%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMMGS-ARVAELLLLHGAEPNCAD 74
L AA G + LL+ GA PN+ G P+ + + RV ELLL GA +
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL 130
+ LT P+H A+ G L + L + GA +V + P+ +A GH +VA+YL
Sbjct: 402 ESGLT-PLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Score = 47.0 bits (110), Expect = 7e-06
Identities = 39/127 (30%), Positives = 57/127 (44%), Gaps = 3/127 (2%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMM-MGSARVAELLLLHGAEPNCAD 74
L AA G+V LLE A PNA G P+ V + + + +LLL G P+
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 599
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRD-VARYLRAA 133
T P+H AA++ ++ L + G + G P+ LA + GH + VA L
Sbjct: 600 WNGYT-PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQ 658
Query: 134 AGGTRGS 140
A G G+
Sbjct: 659 ANGNLGN 665
Score = 46.6 bits (109), Expect = 9e-06
Identities = 33/116 (28%), Positives = 55/116 (47%), Gaps = 2/116 (1%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVM-MMGSARVAELLLLHGAEPNCAD 74
L A + V + LL+ GA +A G P+ V MG + + LL GA PN ++
Sbjct: 375 LHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN 434
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL 130
T P+H AAR G + L + A+++ + + P+ A +GH ++ + L
Sbjct: 435 VKVET-PLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLL 489
Score = 46.6 bits (109), Expect = 9e-06
Identities = 42/129 (32%), Positives = 58/129 (44%), Gaps = 4/129 (3%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQ-VMMMGSARVAELLLLHGAEPNCAD 74
L AA G E + LL+ A NA + P+ +G + +LLL + A PN A
Sbjct: 441 LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT 500
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL--RA 132
A T P+H AAREG ++T++ L A G P+ +A + G VA L R
Sbjct: 501 TAGHT-PLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERD 559
Query: 133 AAGGTRGSN 141
A G N
Sbjct: 560 AHPNAAGKN 568
Score = 38.5 bits (88), Expect = 0.002
Identities = 34/116 (29%), Positives = 49/116 (42%), Gaps = 2/116 (1%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMM-GSARVAELLLLHGAEPNCAD 74
L AA + + LL GA N G P+ + G+ + LLL GA+
Sbjct: 210 LHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKT 269
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL 130
LT P+H AAR G + +L GA + + G P+ +A + H D R L
Sbjct: 270 KDELT-PLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 324
Score = 37.7 bits (86), Expect = 0.004
Identities = 39/160 (24%), Positives = 57/160 (35%), Gaps = 35/160 (21%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMMGS------------------- 56
L AA G V LL+ GA A G PI + G
Sbjct: 276 LHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDIT 335
Query: 57 ---------------ARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAG 101
RVA++LL GA+PN T P+H A ++ + + +L + G
Sbjct: 336 LDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFT-PLHIACKKNHVRVMELLLKTG 394
Query: 102 ARLDVRDAWGRLPVDLAEELGHRDVARYLRAAAGGTRGSN 141
A +D G P+ +A +GH + + L SN
Sbjct: 395 ASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN 434
Score = 33.9 bits (76), Expect = 0.057
Identities = 27/83 (32%), Positives = 39/83 (46%), Gaps = 2/83 (2%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPI-QVMMMGSARVAELLLLHGAEPNCAD 74
L A+ G ++ V+ LL+ A NA G P+ Q G + LLL +GA PN
Sbjct: 705 LHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVS 764
Query: 75 PATLTRPVHDAAREGFLDTLVVL 97
+ T P+ A R G++ VL
Sbjct: 765 -SDGTTPLAIAKRLGYISVTDVL 786
>gi|215598824 ankyrin repeat and SOCS box-containing 10 isoform 2
[Homo sapiens]
Length = 474
Score = 52.4 bits (124), Expect = 2e-07
Identities = 38/101 (37%), Positives = 50/101 (49%), Gaps = 1/101 (0%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMM-MGSARVAELLLLHGAEPNCAD 74
L A A G V LL AGA PN + G+RP+ + G+ AELLL GA +
Sbjct: 197 LHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRS 256
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPV 115
P+H AAR G ++ +L R GA D R+A G P+
Sbjct: 257 EEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPL 297
Score = 42.0 bits (97), Expect = 2e-04
Identities = 37/127 (29%), Positives = 50/127 (39%), Gaps = 15/127 (11%)
Query: 6 GSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPI--------------QV 51
G S E L AA G VE LL GA P+A N+ G P+ +
Sbjct: 254 GRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEA 313
Query: 52 MMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWG 111
++ LLL GA+ + AD RP+H A R G + +L G + D G
Sbjct: 314 TTARCLQLCSLLLSAGADADAADQDK-QRPLHLACRRGHAAVVELLLSCGVSANTMDYGG 372
Query: 112 RLPVDLA 118
P+ A
Sbjct: 373 HTPLHCA 379
Score = 28.9 bits (63), Expect = 1.8
Identities = 25/76 (32%), Positives = 34/76 (44%), Gaps = 2/76 (2%)
Query: 55 GSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLP 114
G V LLL A P+ A P T +H+A G + VL AGA ++ D G+ P
Sbjct: 172 GHTEVLRLLLRRRARPDSA-PGGRTA-LHEACAAGHTACVHVLLVAGADPNIADQDGKRP 229
Query: 115 VDLAEELGHRDVARYL 130
+ L G + A L
Sbjct: 230 LHLCRGPGTLECAELL 245
>gi|215598819 ankyrin repeat and SOCS box-containing 10 isoform 1
[Homo sapiens]
Length = 512
Score = 52.4 bits (124), Expect = 2e-07
Identities = 38/101 (37%), Positives = 50/101 (49%), Gaps = 1/101 (0%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMM-MGSARVAELLLLHGAEPNCAD 74
L A A G V LL AGA PN + G+RP+ + G+ AELLL GA +
Sbjct: 197 LHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRS 256
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPV 115
P+H AAR G ++ +L R GA D R+A G P+
Sbjct: 257 EEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPL 297
Score = 42.0 bits (97), Expect = 2e-04
Identities = 37/127 (29%), Positives = 50/127 (39%), Gaps = 15/127 (11%)
Query: 6 GSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPI--------------QV 51
G S E L AA G VE LL GA P+A N+ G P+ +
Sbjct: 254 GRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEA 313
Query: 52 MMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWG 111
++ LLL GA+ + AD RP+H A R G + +L G + D G
Sbjct: 314 TTARCLQLCSLLLSAGADADAADQDK-QRPLHLACRRGHAAVVELLLSCGVSANTMDYGG 372
Query: 112 RLPVDLA 118
P+ A
Sbjct: 373 HTPLHCA 379
Score = 28.9 bits (63), Expect = 1.8
Identities = 25/76 (32%), Positives = 34/76 (44%), Gaps = 2/76 (2%)
Query: 55 GSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLP 114
G V LLL A P+ A P T +H+A G + VL AGA ++ D G+ P
Sbjct: 172 GHTEVLRLLLRRRARPDSA-PGGRTA-LHEACAAGHTACVHVLLVAGADPNIADQDGKRP 229
Query: 115 VDLAEELGHRDVARYL 130
+ L G + A L
Sbjct: 230 LHLCRGPGTLECAELL 245
>gi|215598806 ankyrin repeat and SOCS box-containing 10 isoform 3
[Homo sapiens]
Length = 452
Score = 52.4 bits (124), Expect = 2e-07
Identities = 38/101 (37%), Positives = 50/101 (49%), Gaps = 1/101 (0%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMM-MGSARVAELLLLHGAEPNCAD 74
L A A G V LL AGA PN + G+RP+ + G+ AELLL GA +
Sbjct: 137 LHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRS 196
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPV 115
P+H AAR G ++ +L R GA D R+A G P+
Sbjct: 197 EEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPL 237
Score = 42.0 bits (97), Expect = 2e-04
Identities = 37/127 (29%), Positives = 50/127 (39%), Gaps = 15/127 (11%)
Query: 6 GSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPI--------------QV 51
G S E L AA G VE LL GA P+A N+ G P+ +
Sbjct: 194 GRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEA 253
Query: 52 MMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWG 111
++ LLL GA+ + AD RP+H A R G + +L G + D G
Sbjct: 254 TTARCLQLCSLLLSAGADADAADQDK-QRPLHLACRRGHAAVVELLLSCGVSANTMDYGG 312
Query: 112 RLPVDLA 118
P+ A
Sbjct: 313 HTPLHCA 319
Score = 28.9 bits (63), Expect = 1.8
Identities = 25/76 (32%), Positives = 34/76 (44%), Gaps = 2/76 (2%)
Query: 55 GSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLP 114
G V LLL A P+ A P T +H+A G + VL AGA ++ D G+ P
Sbjct: 112 GHTEVLRLLLRRRARPDSA-PGGRTA-LHEACAAGHTACVHVLLVAGADPNIADQDGKRP 169
Query: 115 VDLAEELGHRDVARYL 130
+ L G + A L
Sbjct: 170 LHLCRGPGTLECAELL 185
>gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]
Length = 835
Score = 52.4 bits (124), Expect = 2e-07
Identities = 36/118 (30%), Positives = 57/118 (48%), Gaps = 4/118 (3%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMM-GSARVAELLLLHGAEPNCAD 74
L A G +E LL+ GA N ++ P+ + G +V LLL GA+ N +
Sbjct: 138 LHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSG 197
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDV--RDAWGRLPVDLAEELGHRDVARYL 130
RP+H A+ +GFL+ +L G++ DV +D +P+ GH D+ +YL
Sbjct: 198 EVG-DRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYL 254
Score = 35.4 bits (80), Expect = 0.020
Identities = 30/109 (27%), Positives = 49/109 (44%), Gaps = 2/109 (1%)
Query: 23 GRVEEVRALLEAGALPNAPNSYGRRPIQVMMM-GSARVAELLLLHGAEPNCADPATLTRP 81
G+ +R L+ G P+ G + + + +A + LL GA+ LT
Sbjct: 79 GKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTA- 137
Query: 82 VHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL 130
+H A G L+ VL + GA ++++DA P+ +A GH V R L
Sbjct: 138 LHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLL 186
>gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]
Length = 936
Score = 52.4 bits (124), Expect = 2e-07
Identities = 36/118 (30%), Positives = 57/118 (48%), Gaps = 4/118 (3%)
Query: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMM-GSARVAELLLLHGAEPNCAD 74
L A G +E LL+ GA N ++ P+ + G +V LLL GA+ N +
Sbjct: 239 LHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSG 298
Query: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDV--RDAWGRLPVDLAEELGHRDVARYL 130
RP+H A+ +GFL+ +L G++ DV +D +P+ GH D+ +YL
Sbjct: 299 EVG-DRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYL 355
Score = 35.4 bits (80), Expect = 0.020
Identities = 30/109 (27%), Positives = 49/109 (44%), Gaps = 2/109 (1%)
Query: 23 GRVEEVRALLEAGALPNAPNSYGRRPIQVMMM-GSARVAELLLLHGAEPNCADPATLTRP 81
G+ +R L+ G P+ G + + + +A + LL GA+ LT
Sbjct: 180 GKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTA- 238
Query: 82 VHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL 130
+H A G L+ VL + GA ++++DA P+ +A GH V R L
Sbjct: 239 LHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLL 287
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.395
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 5,873,048
Number of Sequences: 37866
Number of extensions: 234812
Number of successful extensions: 1584
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 181
Number of HSP's successfully gapped in prelim test: 102
Number of HSP's that attempted gapping in prelim test: 723
Number of HSP's gapped (non-prelim): 728
length of query: 156
length of database: 18,247,518
effective HSP length: 94
effective length of query: 62
effective length of database: 14,688,114
effective search space: 910663068
effective search space used: 910663068
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 57 (26.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.