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Search of human proteins with 4502399
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4502399 filensin isoform 1 [Homo sapiens]
(665 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4502399 filensin isoform 1 [Homo sapiens] 1296 0.0
gi|239787151 filensin isoform 2 [Homo sapiens] 1053 0.0
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 103 5e-22
gi|27894337 keratin 20 [Homo sapiens] 92 2e-18
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 83 7e-16
gi|105990539 neurofilament, light polypeptide 68kDa [Homo sapiens] 82 1e-15
gi|14917119 keratin 34 [Homo sapiens] 82 2e-15
gi|94538345 keratin 35 [Homo sapiens] 82 2e-15
gi|14917117 keratin 33A [Homo sapiens] 81 3e-15
gi|10337581 type I hair keratin 3B [Homo sapiens] 80 5e-15
gi|116488398 keratin 32 [Homo sapiens] 80 8e-15
gi|196115290 glial fibrillary acidic protein isoform 2 [Homo sap... 80 8e-15
gi|14917115 keratin 31 [Homo sapiens] 79 1e-14
gi|4503979 glial fibrillary acidic protein isoform 1 [Homo sapiens] 78 3e-14
gi|15431310 keratin 14 [Homo sapiens] 78 3e-14
gi|114431246 keratin 25D [Homo sapiens] 76 9e-14
gi|125490370 type I hair keratin KA36 [Homo sapiens] 75 1e-13
gi|195972866 keratin 10 [Homo sapiens] 75 1e-13
gi|4504919 keratin 8 [Homo sapiens] 75 2e-13
gi|4504927 keratin 36 [Homo sapiens] 75 2e-13
gi|4557701 keratin 17 [Homo sapiens] 74 4e-13
gi|131412228 keratin 13 isoform b [Homo sapiens] 74 4e-13
gi|131412225 keratin 13 isoform a [Homo sapiens] 74 4e-13
gi|55956899 keratin 9 [Homo sapiens] 74 6e-13
gi|194018511 keratin 77 [Homo sapiens] 74 6e-13
gi|148277620 type I hair keratin KA35 [Homo sapiens] 72 2e-12
gi|14249342 internexin neuronal intermediate filament protein, a... 72 2e-12
gi|62414289 vimentin [Homo sapiens] 71 4e-12
gi|55770882 keratin 37 [Homo sapiens] 70 5e-12
gi|5031839 keratin 6A [Homo sapiens] 70 5e-12
>gi|4502399 filensin isoform 1 [Homo sapiens]
Length = 665
Score = 1296 bits (3353), Expect = 0.0
Identities = 665/665 (100%), Positives = 665/665 (100%)
Query: 1 MYRRSYVFQTRKEQYEHADEASRAAEPERPADEGWAGATSLAALQGLGERVAAHVQRARA 60
MYRRSYVFQTRKEQYEHADEASRAAEPERPADEGWAGATSLAALQGLGERVAAHVQRARA
Sbjct: 1 MYRRSYVFQTRKEQYEHADEASRAAEPERPADEGWAGATSLAALQGLGERVAAHVQRARA 60
Query: 61 LEQRHAGLRRQLDAFQRLGELAGPEDALARQVESNRQRVRDLEAERARLERQGTEAQRAL 120
LEQRHAGLRRQLDAFQRLGELAGPEDALARQVESNRQRVRDLEAERARLERQGTEAQRAL
Sbjct: 61 LEQRHAGLRRQLDAFQRLGELAGPEDALARQVESNRQRVRDLEAERARLERQGTEAQRAL 120
Query: 121 DEFRSKYENECECQLLLKEMLERLNKEADEALLHNLRLQLEAQFLQDDISAAKDRHKKNL 180
DEFRSKYENECECQLLLKEMLERLNKEADEALLHNLRLQLEAQFLQDDISAAKDRHKKNL
Sbjct: 121 DEFRSKYENECECQLLLKEMLERLNKEADEALLHNLRLQLEAQFLQDDISAAKDRHKKNL 180
Query: 181 LEVQTYISILQQIIHTTPPASIVTSGMREEKLLTEREVAALRSQLEEGREVLSHLQAQRV 240
LEVQTYISILQQIIHTTPPASIVTSGMREEKLLTEREVAALRSQLEEGREVLSHLQAQRV
Sbjct: 181 LEVQTYISILQQIIHTTPPASIVTSGMREEKLLTEREVAALRSQLEEGREVLSHLQAQRV 240
Query: 241 ELQAQTTTLEQAIKSAHECYDDEIQLYNEQIETLRKEIEETERVLEKSSYDCRQLAVAQQ 300
ELQAQTTTLEQAIKSAHECYDDEIQLYNEQIETLRKEIEETERVLEKSSYDCRQLAVAQQ
Sbjct: 241 ELQAQTTTLEQAIKSAHECYDDEIQLYNEQIETLRKEIEETERVLEKSSYDCRQLAVAQQ 300
Query: 301 TLKNELDRYHRIIEIEGNRLTSAFIETPIPLFTQSHGVSLSTGSGGKDLTRALQDITAAK 360
TLKNELDRYHRIIEIEGNRLTSAFIETPIPLFTQSHGVSLSTGSGGKDLTRALQDITAAK
Sbjct: 301 TLKNELDRYHRIIEIEGNRLTSAFIETPIPLFTQSHGVSLSTGSGGKDLTRALQDITAAK 360
Query: 361 PRQKALPKNVPRRKEIITKDKTNGALEDAPLKGLEDTKLVQVVLKEESESKFESESKEVS 420
PRQKALPKNVPRRKEIITKDKTNGALEDAPLKGLEDTKLVQVVLKEESESKFESESKEVS
Sbjct: 361 PRQKALPKNVPRRKEIITKDKTNGALEDAPLKGLEDTKLVQVVLKEESESKFESESKEVS 420
Query: 421 PLTQEGAPEDVPDGGQISKGFGKLYRKVKEKVRSPKEPETPTELYTKERHVLVTGDANYV 480
PLTQEGAPEDVPDGGQISKGFGKLYRKVKEKVRSPKEPETPTELYTKERHVLVTGDANYV
Sbjct: 421 PLTQEGAPEDVPDGGQISKGFGKLYRKVKEKVRSPKEPETPTELYTKERHVLVTGDANYV 480
Query: 481 DPRFYVSSITAKGGVAVSVAEDSVLYDGQVEPSPESPKPPLENGQVGLQEKEDGQPIDQQ 540
DPRFYVSSITAKGGVAVSVAEDSVLYDGQVEPSPESPKPPLENGQVGLQEKEDGQPIDQQ
Sbjct: 481 DPRFYVSSITAKGGVAVSVAEDSVLYDGQVEPSPESPKPPLENGQVGLQEKEDGQPIDQQ 540
Query: 541 PIDKEIEPDGAELEGPEEKREGEERDEESRRPCAMVTPGAEEPSIPEPPKPAADQDGAEV 600
PIDKEIEPDGAELEGPEEKREGEERDEESRRPCAMVTPGAEEPSIPEPPKPAADQDGAEV
Sbjct: 541 PIDKEIEPDGAELEGPEEKREGEERDEESRRPCAMVTPGAEEPSIPEPPKPAADQDGAEV 600
Query: 601 LGTRSRSLPEKGPPKALAYKTVEVVESIEKISTESIQTYEETAVIVETMIGKTKSDKKKS 660
LGTRSRSLPEKGPPKALAYKTVEVVESIEKISTESIQTYEETAVIVETMIGKTKSDKKKS
Sbjct: 601 LGTRSRSLPEKGPPKALAYKTVEVVESIEKISTESIQTYEETAVIVETMIGKTKSDKKKS 660
Query: 661 GEKSS 665
GEKSS
Sbjct: 661 GEKSS 665
>gi|239787151 filensin isoform 2 [Homo sapiens]
Length = 540
Score = 1053 bits (2722), Expect = 0.0
Identities = 539/539 (100%), Positives = 539/539 (100%)
Query: 127 YENECECQLLLKEMLERLNKEADEALLHNLRLQLEAQFLQDDISAAKDRHKKNLLEVQTY 186
YENECECQLLLKEMLERLNKEADEALLHNLRLQLEAQFLQDDISAAKDRHKKNLLEVQTY
Sbjct: 2 YENECECQLLLKEMLERLNKEADEALLHNLRLQLEAQFLQDDISAAKDRHKKNLLEVQTY 61
Query: 187 ISILQQIIHTTPPASIVTSGMREEKLLTEREVAALRSQLEEGREVLSHLQAQRVELQAQT 246
ISILQQIIHTTPPASIVTSGMREEKLLTEREVAALRSQLEEGREVLSHLQAQRVELQAQT
Sbjct: 62 ISILQQIIHTTPPASIVTSGMREEKLLTEREVAALRSQLEEGREVLSHLQAQRVELQAQT 121
Query: 247 TTLEQAIKSAHECYDDEIQLYNEQIETLRKEIEETERVLEKSSYDCRQLAVAQQTLKNEL 306
TTLEQAIKSAHECYDDEIQLYNEQIETLRKEIEETERVLEKSSYDCRQLAVAQQTLKNEL
Sbjct: 122 TTLEQAIKSAHECYDDEIQLYNEQIETLRKEIEETERVLEKSSYDCRQLAVAQQTLKNEL 181
Query: 307 DRYHRIIEIEGNRLTSAFIETPIPLFTQSHGVSLSTGSGGKDLTRALQDITAAKPRQKAL 366
DRYHRIIEIEGNRLTSAFIETPIPLFTQSHGVSLSTGSGGKDLTRALQDITAAKPRQKAL
Sbjct: 182 DRYHRIIEIEGNRLTSAFIETPIPLFTQSHGVSLSTGSGGKDLTRALQDITAAKPRQKAL 241
Query: 367 PKNVPRRKEIITKDKTNGALEDAPLKGLEDTKLVQVVLKEESESKFESESKEVSPLTQEG 426
PKNVPRRKEIITKDKTNGALEDAPLKGLEDTKLVQVVLKEESESKFESESKEVSPLTQEG
Sbjct: 242 PKNVPRRKEIITKDKTNGALEDAPLKGLEDTKLVQVVLKEESESKFESESKEVSPLTQEG 301
Query: 427 APEDVPDGGQISKGFGKLYRKVKEKVRSPKEPETPTELYTKERHVLVTGDANYVDPRFYV 486
APEDVPDGGQISKGFGKLYRKVKEKVRSPKEPETPTELYTKERHVLVTGDANYVDPRFYV
Sbjct: 302 APEDVPDGGQISKGFGKLYRKVKEKVRSPKEPETPTELYTKERHVLVTGDANYVDPRFYV 361
Query: 487 SSITAKGGVAVSVAEDSVLYDGQVEPSPESPKPPLENGQVGLQEKEDGQPIDQQPIDKEI 546
SSITAKGGVAVSVAEDSVLYDGQVEPSPESPKPPLENGQVGLQEKEDGQPIDQQPIDKEI
Sbjct: 362 SSITAKGGVAVSVAEDSVLYDGQVEPSPESPKPPLENGQVGLQEKEDGQPIDQQPIDKEI 421
Query: 547 EPDGAELEGPEEKREGEERDEESRRPCAMVTPGAEEPSIPEPPKPAADQDGAEVLGTRSR 606
EPDGAELEGPEEKREGEERDEESRRPCAMVTPGAEEPSIPEPPKPAADQDGAEVLGTRSR
Sbjct: 422 EPDGAELEGPEEKREGEERDEESRRPCAMVTPGAEEPSIPEPPKPAADQDGAEVLGTRSR 481
Query: 607 SLPEKGPPKALAYKTVEVVESIEKISTESIQTYEETAVIVETMIGKTKSDKKKSGEKSS 665
SLPEKGPPKALAYKTVEVVESIEKISTESIQTYEETAVIVETMIGKTKSDKKKSGEKSS
Sbjct: 482 SLPEKGPPKALAYKTVEVVESIEKISTESIQTYEETAVIVETMIGKTKSDKKKSGEKSS 540
Score = 38.1 bits (87), Expect = 0.026
Identities = 21/64 (32%), Positives = 35/64 (54%), Gaps = 3/64 (4%)
Query: 87 ALARQVESNRQRVRDLEAERARLERQGTEAQRALDEFRSKYENECECQLLLKEMLERLNK 146
AL Q+E R+ + L+A+R L+ Q T ++A+ Y++E + L E +E L K
Sbjct: 95 ALRSQLEEGREVLSHLQAQRVELQAQTTTLEQAIKSAHECYDDEIQ---LYNEQIETLRK 151
Query: 147 EADE 150
E +E
Sbjct: 152 EIEE 155
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 103 bits (257), Expect = 5e-22
Identities = 132/680 (19%), Positives = 272/680 (40%), Gaps = 68/680 (10%)
Query: 44 LQGLGERVAAHVQRARALEQRHAGLRRQLDAF-QRLGELAGPEDALARQVESNRQRVRDL 102
LQGL +R A ++++ LEQ++ + ++ A Q+ A DA +++ R + +
Sbjct: 105 LQGLNDRFAGYIEKVHYLEQQNKEIEAEIQALRQKQASHAQLGDAYDQEIRELRATLEMV 164
Query: 103 EAERARLERQGTEAQRALDEFRSKYENECECQLLLKEMLERLNKEADEALLHNLRLQLEA 162
E+A+++ + + + ++E E + + + L K+ +EA L + L +
Sbjct: 165 NHEKAQVQLDSDHLEEDIHRLKERFEEEARLRDDTEAAIRALRKDIEEASLVKVELDKKV 224
Query: 163 QFLQDDISAAKDRHKKNLLEVQTYI------------------SILQQIIHTTPPASIVT 204
Q LQD+++ + H++ + ++ I + L++I S
Sbjct: 225 QSLQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYLKTDISTALKEIRSQLESHSDQN 284
Query: 205 SGMREE-------KL--LTEREVAALRSQLEEGREVLSHLQAQRVELQAQTTT---LEQA 252
EE KL E+ A+RS EE E LQ++ +EL++ T LE+
Sbjct: 285 MHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVRGTKESLERQ 344
Query: 253 IKSAHECYDDEIQLYNEQIETLRKEIEETERVLEKSSYDCRQLAVAQQTLKNELDRYHRI 312
+ E ++ ++ Y + I+ L E+ T+ + + + + L + L E+ Y ++
Sbjct: 345 LSDIEERHNHDLSSYQDTIQQLENELRGTKWEMARHLREYQDLLNVKMALDIEIAAYRKL 404
Query: 313 IEIEGNRLTSAFIETPIPLFTQSHGVSLST------------------------GSGGKD 348
+E E R ++ PL+T +++S+ + +D
Sbjct: 405 LEGEETRFSTFAGSITGPLYTHRPPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVED 464
Query: 349 LTRALQDITAAKPRQKALPKNVPRRKEIITKDKTNGALEDAPLKGLEDTKLVQVVLKEES 408
+++ A + A+ +++ K++ A E+ K +KEE
Sbjct: 465 EKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEE 524
Query: 409 ESKFESESKEVSPLTQEGAPED-VPDGGQISKGFGKLYRKVKEKVRSPKEPETPTELYTK 467
K E E +E EGA D +GG +G + +E+ + E E +
Sbjct: 525 GEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKE 584
Query: 468 ERHVLVTGDANYVDPRFYVSSITAKGGVAVSVAEDSVLYDGQVEPSPESP-----KPPLE 522
E+ V + + K A S S + + P P+SP K P+
Sbjct: 585 EKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVP 644
Query: 523 NGQVGLQEKEDGQPIDQQPIDKEIEPDGAELEGPEEKREGEERDE-ESRRPCAMVTPGAE 581
V E++ P+ + P++++ + ++ E+ + + E + A V G +
Sbjct: 645 KSPV---EEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQ 701
Query: 582 EPSIPEPPKPAADQDGAEVLGTRSRSLPEKGPPKALAYKTVEVVESIEKISTESIQTYEE 641
+ + K A ++ E + + +PEK KA + E V + I T+S++ + E
Sbjct: 702 KEEEEKEVKEAPKEEKVEKKEEKPKDVPEK--KKAESPVKEEAVAEVVTI-TKSVKVHLE 758
Query: 642 TAVIVETMIGKTKSDKKKSG 661
E + + +K+K+G
Sbjct: 759 KETKEEGKPLQQEKEKEKAG 778
>gi|27894337 keratin 20 [Homo sapiens]
Length = 424
Score = 92.0 bits (227), Expect = 2e-18
Identities = 71/316 (22%), Positives = 140/316 (44%), Gaps = 31/316 (9%)
Query: 43 ALQGLGERVAAHVQRARALEQRHAGLRRQLDAFQRLGELAGPED--ALARQVESNRQRVR 100
A+Q L +R+A+++++ R LEQ ++ L Q+ + D A RQ+E R +++
Sbjct: 73 AMQNLNDRLASYLEKVRTLEQSNSKLEVQIKQWYETNAPRAGRDYSAYYRQIEELRSQIK 132
Query: 101 DLEAERARLERQGTEAQRALDEFRSKYENECECQLLLKEMLERLNKEADEALLHNLRLQL 160
D + + AR Q A+ A ++FR KYE E +L ++ L+ LNK D+ LH L++
Sbjct: 133 DAQLQNARCVLQIDNAKLAAEDFRLKYETERGIRLTVEADLQGLNKVFDDLTLHKTDLEI 192
Query: 161 EAQFLQDDISAAKDRHKKNLLEVQTYISILQQIIHTTPPA---SIVTSGMR--------- 208
+ + L D++ K H++ + + ++ + P ++ + MR
Sbjct: 193 QIEELNKDLALLKKEHQEEVDGLHKHLGNTVNVEVDAAPGLNLGVIMNEMRQKYEVMAQK 252
Query: 209 ---EEKLLTEREVAALRSQLEEGREVLSHLQAQRVELQ--------------AQTTTLEQ 251
E K ER+ A L+ Q+ E L + Q EL+ + +LE
Sbjct: 253 NLQEAKEQFERQTAVLQQQVTVNTEELKGTEVQLTELRRTSQSLEIELQSHLSMKESLEH 312
Query: 252 AIKSAHECYDDEIQLYNEQIETLRKEIEETERVLEKSSYDCRQLAVAQQTLKNELDRYHR 311
++ Y ++ + +L ++ + +E+ + + L + L+ E+ Y R
Sbjct: 313 TLEETKARYSSQLANLQSLLSSLEAQLMQIRSNMERQNNEYHILLDIKTRLEQEIATYRR 372
Query: 312 IIEIEGNRLTSAFIET 327
++E E + T + T
Sbjct: 373 LLEGEDVKTTEYQLST 388
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 83.2 bits (204), Expect = 7e-16
Identities = 144/648 (22%), Positives = 242/648 (37%), Gaps = 102/648 (15%)
Query: 44 LQGLGERVAAHVQRARALEQRH-------AGLRRQLDAFQRLGELAGPEDALARQVESNR 96
LQ L +R A ++ + R LE + A LR+Q +GEL R+V R
Sbjct: 101 LQALNDRFAGYIDKVRQLEAHNRSLEGEAAALRQQQAGRSAMGEL------YEREVREMR 154
Query: 97 QRVRDLEAERARLERQGTEAQRALDEFRSKYENECECQLLLKEMLERLNKEADEALLHNL 156
V L A R +L + + R + ++E + + L + A EA +
Sbjct: 155 GAVLRLGAARGQLRLEQEHLLEDIAHVRQRLDDEARQREEAEAAARALARFAQEAEAARV 214
Query: 157 RLQLEAQFLQDDISAAKDRHKKNLLEVQTYI----SILQQIIHTTPPA--SIVTSGMREE 210
LQ +AQ LQ++ + H++ + E+ I + Q+ T A VTS +RE
Sbjct: 215 DLQKKAQALQEECGYLRRHHQEEVGELLGQIQGSGAAQAQMQAETRDALKCDVTSALREI 274
Query: 211 KLLTEREVA--------------------------ALRSQLEEGREVLSHLQAQRVELQA 244
+ E A+RS EE E LQA+ EL+A
Sbjct: 275 RAQLEGHAVQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEITEYRRQLQARTTELEA 334
Query: 245 QTTT---LEQAIKSAHECYDDEIQLYNEQIETLRKEIEETERVLEKSSYDCRQLAVAQQT 301
+T LE+ + + +I Y E I+ L E+ T+ + + + L +
Sbjct: 335 LKSTKDSLERQRSELEDRHQADIASYQEAIQQLDAELRNTKWEMAAQLREYQDLLNVKMA 394
Query: 302 LKNELDRYHRIIEIEGNRLTSAFIETPIPLFTQSHGVSLSTGSGGKDLTRALQDITAAKP 361
L E+ Y +++E E R+ PIP L L I +
Sbjct: 395 LDIEIAAYRKLLEGEECRIGFG----PIPF----------------SLPEGLPKIPSVST 434
Query: 362 RQKALPKNVPRRKEIITKDKTNGALEDAPLKGLEDTKLVQVVLKEESESKFESESKEVSP 421
K K+ + K + +K +E+ E+T++ + V +EE + E E KE
Sbjct: 435 HIKV--KSEEKIKVVEKSEKETVIVEEQ----TEETQVTEEVTEEEEKEAKEEEGKE--- 485
Query: 422 LTQEGAPEDVPDGG----------QISKGFGKLYRKVKEKVRSP--------KEPETPTE 463
+EG E+ +GG + + + VKE+ +SP +E ++P E
Sbjct: 486 --EEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAE 543
Query: 464 LYTKERHVLVTGDANYVDPRF-YVSSITAKGGVAVSVAEDSVLYDGQVEPSPESPKPPLE 522
+ + E+ + P AK V E + + SP K P E
Sbjct: 544 VKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSP-E 602
Query: 523 NGQVGLQEKEDGQPIDQQPIDKEIEPDGAELEGPEEKREGEERDEESRRPCAMVTPGAEE 582
+ ++E+ + P+ KE AE++ PE+ + + EE++ P +P EE
Sbjct: 603 KAKSPVKEEAKSPAEAKSPV-KEEAKSPAEVKSPEKAKSPTK--EEAKSPEKAKSPEKEE 659
Query: 583 PSIPEPPKPAADQDGAEVLGTRSRSLPEKGPPKALAYKTVEVVESIEK 630
PE K + +S E P+ E +S EK
Sbjct: 660 AKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEK 707
Score = 41.2 bits (95), Expect = 0.003
Identities = 69/322 (21%), Positives = 123/322 (38%), Gaps = 32/322 (9%)
Query: 359 AKPRQKALPKNVPRRKEIITKDKTNGALEDAPLKGLEDT-KLVQVVLKEESESKFESESK 417
AK K K+ + K + ++ + +P+K T + + +KEE++S +++S
Sbjct: 694 AKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSP 753
Query: 418 EVSPLTQEGAPE-DVPDGGQISKGFGKLYRK----VKEKVRSPKEPETPTELYTKERHVL 472
E + +PE P + K K VKE+V+SP++ ++P +
Sbjct: 754 EKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLK--------- 804
Query: 473 VTGDANYVDPRFYVSSITAKGGVAVSVAEDSVLYDGQVEPSPESPKPPLENGQVGLQEKE 532
D + I K V V E+ + +V+ P+ + +EK+
Sbjct: 805 -------EDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKK 857
Query: 533 DGQ----PIDQQPIDKEIEPDGAELEGPEEKREGEERDEESRRPCAMVTPGAEEPSIPEP 588
D + P + P K E +E P+E + E + EE+ + TP E P+ E
Sbjct: 858 DSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKV-EAKKEEAEDKKKVPTPEKEAPAKVEV 916
Query: 589 PKPAADQDGAEVLGTRSRSLPEKGPPKALAYKTV-----EVVESIEKISTESIQTYEETA 643
+ A ++ EV K P K K + E K E +T +
Sbjct: 917 KEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAK 976
Query: 644 VIVETMIGKTKSDKKKSGEKSS 665
+T+ + K + EKSS
Sbjct: 977 EDDKTLSKEPSKPKAEKAEKSS 998
Score = 40.8 bits (94), Expect = 0.004
Identities = 69/314 (21%), Positives = 127/314 (40%), Gaps = 31/314 (9%)
Query: 359 AKPRQKALPKNVPRRKEIITKDKTNGALEDAPLKG-LEDTKLVQVVLKEESESKFESESK 417
AK +K K+ + K + + + +P+K + + + +KEE++S K
Sbjct: 652 AKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSP----EK 707
Query: 418 EVSPLTQEG-APEDVPDG-GQISKGFGKLYRKVKEKVRSPKEPETPTELYTKERHVLVTG 475
SP+ +E +PE + +K K VKE+ +SP++ ++P + T +
Sbjct: 708 AKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAK 767
Query: 476 DANYVDPRFYVSSITAKGGVAVSVAEDSVLYDGQVEPSPESPKPPLENGQVGLQEKEDGQ 535
+ R K A S ++ V SPE K PL KED +
Sbjct: 768 TPAKEEARSPADKFPEK---AKSPVKEEV-------KSPEKAKSPL---------KEDAK 808
Query: 536 -PIDQQPIDKEIEPDGAELEGPEE--KREGEERDEESRRPCAMVTPGAEEPSIPEPPKPA 592
P + P +E++ E E P+E +E ++ EE + P T ++ E PK
Sbjct: 809 APEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKE 868
Query: 593 ADQDGAEVLGTRSRSLPEKGPPKALAYKTVE--VVESIEKISTESIQTYEETAVIVETMI 650
A + E + P++ +A + + V + EK + ++ E+ +T +
Sbjct: 869 APKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEV 928
Query: 651 GKTKSDKKKSGEKS 664
K + D K+ E S
Sbjct: 929 AKKEPDDAKAKEPS 942
>gi|105990539 neurofilament, light polypeptide 68kDa [Homo sapiens]
Length = 543
Score = 82.4 bits (202), Expect = 1e-15
Identities = 99/431 (22%), Positives = 180/431 (41%), Gaps = 37/431 (8%)
Query: 42 AALQGLGERVAAHVQRARALEQRHAGLRRQLDAF-QRLGELAGPEDALARQVESNRQRVR 100
A LQ L +R A+ ++R LEQ++ L +L Q+ E + +++ R
Sbjct: 92 AQLQDLNDRFASFIERVHELEQQNKVLEAELLVLRQKHSEPSRFRALYEQEIRDLRLAAE 151
Query: 101 DLEAERARLERQGTEAQRALDEFRSKYENECECQLLLKEMLERLNKEADEALLHNLRLQL 160
D E+ L+ + + L +++YE E + + L K ADEA L L+
Sbjct: 152 DATNEKQALQGEREGLEETLRNLQARYEEEVLSREDAEGRLMEARKGADEAALARAELEK 211
Query: 161 EAQFLQDDISAAKDRHKKNLLEVQTYISILQQIIH---TTPPASIVTSGMRE--EKL--- 212
L D+IS K H++ + E+Q I Q + T P S +R EKL
Sbjct: 212 RIDSLMDEISFLKKVHEEEIAELQAQIQYAQISVEMDVTKPDLSAALKDIRAQYEKLAAK 271
Query: 213 ---------------LTE---REVAALRSQLEEGREVLSHLQAQRVELQA---QTTTLEQ 251
LTE + A+R+ +E E L+A+ +E++A LE+
Sbjct: 272 NMQNAEEWFKSRFTVLTESAAKNTDAVRAAKDEVSESRRLLKAKTLEIEACRGMNEALEK 331
Query: 252 AIKSAHECYDDEIQLYNEQIETLRKEIEETERVLEKSSYDCRQLAVAQQTLKNELDRYHR 311
++ + + +I + I L E+ T+ + + + + L + L E+ Y +
Sbjct: 332 QLQELEDKQNADISAMQDTINKLENELRTTKSEMARYLKEYQDLLNVKMALDIEIAAYRK 391
Query: 312 IIEIEGNRLTSAFIETPIPLFTQSHGVSLSTGSGGKDLTRALQDITAAKPR--QKALPKN 369
++E E RL+ + + ++QS V + GG + L T + P + +
Sbjct: 392 LLEGEETRLSFTSVGSITSGYSQSSQVFGRSAYGGLQTSSYLMS-TRSFPSYYTSHVQEE 450
Query: 370 VPRRKEIITKDKTNGALEDAPLKGLEDTKLVQVVLKEESESKFESESKEVSPLTQEGAPE 429
+E I K A ++ P +G + + KEE+E + +E +E + E A E
Sbjct: 451 QIEVEETIEAAKAEEAKDEPPSEGEAEEEEKD---KEEAEEEEAAEEEEAAKEESEEAKE 507
Query: 430 DVPDGGQISKG 440
+ +GG+ +G
Sbjct: 508 E-EEGGEGEEG 517
>gi|14917119 keratin 34 [Homo sapiens]
Length = 436
Score = 82.0 bits (201), Expect = 2e-15
Identities = 70/319 (21%), Positives = 143/319 (44%), Gaps = 31/319 (9%)
Query: 33 EGWAGATSLAALQGLGERVAAHVQRARALEQRHAGLRRQLDAFQRLGE--LAGPEDALAR 90
EG + +Q L +R+A+++++ R LE+ +A L + + + E L + +
Sbjct: 91 EGSFNGSEKETMQFLNDRLASYLEKVRQLERDNAELEKLIQERSQQQEPLLCPSYQSYFK 150
Query: 91 QVESNRQRVRDLEAERARLERQGTEAQRALDEFRSKYENECECQLLLKEMLERLNKEADE 150
+E +Q++ +AE ARL A+ A D+FRSKY+ E +LL++ + + + DE
Sbjct: 151 TIEELQQKILCAKAENARLVVNIDNAKLASDDFRSKYQTEQSLRLLVESDINSIRRILDE 210
Query: 151 ALLHNLRLQLEAQFLQDDISAAKDRHKKNL------------LEVQTYISI-LQQIIHTT 197
L L+ + + L++++ K H++ + +EV T ++ L Q+++ T
Sbjct: 211 LTLCKSDLESQVESLREELICLKKNHEEEVNTLRSQLGDRLNVEVDTAPTVDLNQVLNET 270
Query: 198 PP--ASIVTSGMREEKLLTEREVAALRSQLEEGREVLSHLQAQRVELQAQTTTLEQAIKS 255
++V RE + + L Q+ E L QA+ +EL+ LE +++
Sbjct: 271 RSQYEALVEINRREVEQWFATQTEELNKQVVSSSEQLQSCQAEIIELRRTVNALEIELQA 330
Query: 256 AHEC--------------YDDEIQLYNEQIETLRKEIEETERVLEKSSYDCRQLAVAQQT 301
H Y ++ I + ++ E LE+ + + + L +
Sbjct: 331 QHNLRDSLENTLTESEAHYSSQLSQVQSLITNVESQLAEIRCDLERQNQEYQVLLDVRAR 390
Query: 302 LKNELDRYHRIIEIEGNRL 320
L+ E++ Y ++E E +L
Sbjct: 391 LECEINTYRSLLESEDCKL 409
>gi|94538345 keratin 35 [Homo sapiens]
Length = 455
Score = 81.6 bits (200), Expect = 2e-15
Identities = 67/323 (20%), Positives = 142/323 (43%), Gaps = 36/323 (11%)
Query: 34 GWAGATSLAA-----LQGLGERVAAHVQRARALEQRHAGLRRQLDAF--QRLGELAGPED 86
GW G L +Q L +R+A ++++ R LEQ +A L ++ + Q++ +
Sbjct: 86 GWFGEGILTGNEKETMQSLNDRLAGYLEKVRQLEQENASLESRIREWCEQQVPYMCPDYQ 145
Query: 87 ALARQVESNRQRVRDLEAERARLERQGTEAQRALDEFRSKYENECECQLLLKEMLERLNK 146
+ R +E +++ +AE ARL + A+ A D+FR+KYE E + L++ + L +
Sbjct: 146 SYFRTIEELQKKTLCSKAENARLVVEIDNAKLAADDFRTKYETEVSLRQLVESDINGLRR 205
Query: 147 EADEALLHNLRLQLEAQFLQDDISAAKDRHKKNLLEVQTYI-SILQQIIHTTPPA----- 200
D+ L L+ + + L++++ K H++ + ++ + L + PP
Sbjct: 206 ILDDLTLCKSDLEAQVESLKEELLCLKKNHEEEVNSLRCQLGDRLNVEVDAAPPVDLNRV 265
Query: 201 ---------SIVTSGMREEKLLTEREVAALRSQLEEGREVLSHLQAQRVELQAQTTTLEQ 251
++V + R+ + + + L Q+ E L QA+ +EL+ LE
Sbjct: 266 LEEMRCQYETLVENNRRDAEDWLDTQSEELNQQVVSSSEQLQSCQAEIIELRRTVNALEI 325
Query: 252 AIKSAHEC--------------YDDEIQLYNEQIETLRKEIEETERVLEKSSYDCRQLAV 297
+++ H Y ++ I + ++ E LE+ + + + L
Sbjct: 326 ELQAQHSMRDALESTLAETEARYSSQLAQMQCMITNVEAQLAEIRADLERQNQEYQVLLD 385
Query: 298 AQQTLKNELDRYHRIIEIEGNRL 320
+ L+ E++ Y ++E E ++L
Sbjct: 386 VRARLECEINTYRGLLESEDSKL 408
>gi|14917117 keratin 33A [Homo sapiens]
Length = 404
Score = 81.3 bits (199), Expect = 3e-15
Identities = 69/321 (21%), Positives = 143/321 (44%), Gaps = 31/321 (9%)
Query: 33 EGWAGATSLAALQGLGERVAAHVQRARALEQRHAGLRRQLDAFQRLGE--LAGPEDALAR 90
EG + +Q L +R+A+++++ R LE+ +A L + + E + + +
Sbjct: 49 EGSFNGSEKETMQFLNDRLASYLEKVRQLERDNAELENLIRERSQQQEPLVCASYQSYFK 108
Query: 91 QVESNRQRVRDLEAERARLERQGTEAQRALDEFRSKYENECECQLLLKEMLERLNKEADE 150
+E +Q++ ++E ARL Q A+ A D+FR+KYE E + L++ + L + DE
Sbjct: 109 TIEELQQKILCSKSENARLVVQIDNAKLASDDFRTKYETELSLRQLVESDINGLRRILDE 168
Query: 151 ALLHNLRLQLEAQFLQDDISAAKDRHKKNL------------LEVQTYISI-LQQIIHTT 197
L L+ + + L++++ K H++ + +EV ++ L Q+++ T
Sbjct: 169 LTLCRSDLEAQVESLKEELLCLKQNHEQEVNTLRCQLGDRLNVEVDAAPTVDLNQVLNET 228
Query: 198 PP--ASIVTSGMREEKLLTEREVAALRSQLEEGREVLSHLQAQRVELQAQTTTLEQAIKS 255
++V + RE + + L Q+ E L QA+ +EL+ LE +++
Sbjct: 229 RSQYEALVETNRREVEQWFATQTEELNKQVVSSSEQLQSYQAEIIELRRTVNALEIELQA 288
Query: 256 AHEC--------------YDDEIQLYNEQIETLRKEIEETERVLEKSSYDCRQLAVAQQT 301
H Y ++ I + ++ E LE+ + + + L +
Sbjct: 289 QHNLRDSLENTLTESEARYSSQLSQVQRLITNVESQLAEIRSDLERQNQEYQVLLDVRAR 348
Query: 302 LKNELDRYHRIIEIEGNRLTS 322
L+ E++ Y ++E E +L S
Sbjct: 349 LECEINTYRSLLESEDCKLPS 369
>gi|10337581 type I hair keratin 3B [Homo sapiens]
Length = 404
Score = 80.5 bits (197), Expect = 5e-15
Identities = 70/321 (21%), Positives = 146/321 (45%), Gaps = 31/321 (9%)
Query: 33 EGWAGATSLAALQGLGERVAAHVQRARALEQRHAGLRRQL-DAFQRLGELAGPE-DALAR 90
EG + +Q L +R+A+++++ R LE+ +A L + + Q+ L P + +
Sbjct: 49 EGSFNGSEKETMQFLNDRLASYLEKVRQLERDNAELENLIRERSQQQEPLLCPSYQSYFK 108
Query: 91 QVESNRQRVRDLEAERARLERQGTEAQRALDEFRSKYENECECQLLLKEMLERLNKEADE 150
+E +Q++ ++E ARL Q A+ A D+FR+KY+ E + L++ + L + DE
Sbjct: 109 TIEELQQKILCSKSENARLVVQIDNAKLAADDFRTKYQTEQSLRQLVESDINSLRRILDE 168
Query: 151 ALLHNLRLQLEAQFLQDDISAAKDRHKKNL------------LEVQTYISI-LQQIIHTT 197
L L+ + + L++++ + K H++ + +EV ++ L Q+++ T
Sbjct: 169 LTLCRSDLEAQMESLKEELLSLKQNHEQEVNTLRCQLGDRLNVEVDAAPAVDLNQVLNET 228
Query: 198 --PPASIVTSGMREEKLLTEREVAALRSQLEEGREVLSHLQAQRVELQAQTTTLEQAIKS 255
++V + RE + + L Q+ E L QA+ +EL+ LE +++
Sbjct: 229 RNQYEALVETNRREVEQWFATQTEELNKQVVSSSEQLQSYQAEIIELRRTVNALEIELQA 288
Query: 256 AHEC--------------YDDEIQLYNEQIETLRKEIEETERVLEKSSYDCRQLAVAQQT 301
H Y ++ I + ++ E LE+ + + + L +
Sbjct: 289 QHNLRYSLENTLTESEARYSSQLSQVQSLITNVESQLAEIRSDLERQNQEYQVLLDVRAR 348
Query: 302 LKNELDRYHRIIEIEGNRLTS 322
L+ E++ Y ++E E +L S
Sbjct: 349 LECEINTYRSLLESEDCKLPS 369
>gi|116488398 keratin 32 [Homo sapiens]
Length = 448
Score = 79.7 bits (195), Expect = 8e-15
Identities = 71/327 (21%), Positives = 137/327 (41%), Gaps = 31/327 (9%)
Query: 33 EGWAGATSLAALQGLGERVAAHVQRARALEQRHAGLRRQLDAFQRLGELAGPEDALA--R 90
EG +Q L +R+A+++ R R LEQ +A L ++ L D + R
Sbjct: 89 EGAFNGNEKETMQFLNDRLASYLTRVRQLEQENAELESRIQEASHSQVLTMTPDYQSHFR 148
Query: 91 QVESNRQRVRDLEAERARLERQGTEAQRALDEFRSKYENECECQLLLKEMLERLNKEADE 150
+E +Q++ +AE AR+ A+ A D+FR+KYE E + L++ + L + D+
Sbjct: 149 TIEELQQKILCTKAENARMVVNIDNAKLAADDFRAKYEAELAMRQLVEADINGLRRILDD 208
Query: 151 ALLHNLRLQLEAQFLQDDISAAKDRHKKNLLEVQTYISILQQIIHTTPPASIVTSGMREE 210
L L+ + + L++++ K H++ + ++ + I P +T + E
Sbjct: 209 LTLCKADLEAQVESLKEELMCLKKNHEEEVGSLRCQLGDRLNIEVDAAPPVDLTRVLEEM 268
Query: 211 KLLTEREVAALRSQLEE---------------GREVLSHLQAQRVELQAQTTTLEQAIKS 255
+ E V A R +EE E L + Q+ ++L+ TLE +++
Sbjct: 269 RCQYEAMVEANRRDVEEWFNMQMEELNQQVATSSEQLQNYQSDIIDLRRTVNTLEIELQA 328
Query: 256 AHEC--------------YDDEIQLYNEQIETLRKEIEETERVLEKSSYDCRQLAVAQQT 301
H Y ++ I + ++ E LE+ + + + L +
Sbjct: 329 QHSLRDSLENTLTESEARYSSQLAQMQCMITNVEAQLAEIRADLERQNQEYQVLLDVRAR 388
Query: 302 LKNELDRYHRIIEIEGNRLTSAFIETP 328
L+ E++ Y ++E E +L TP
Sbjct: 389 LEGEINTYRSLLENEDCKLPCNPCSTP 415
>gi|196115290 glial fibrillary acidic protein isoform 2 [Homo
sapiens]
Length = 431
Score = 79.7 bits (195), Expect = 8e-15
Identities = 82/354 (23%), Positives = 151/354 (42%), Gaps = 43/354 (12%)
Query: 38 ATSLAALQGLGERVAAHVQRARALEQRHAGLRRQLDAFQRLGELAGPEDALARQVESNRQ 97
A+ A + L +R A+++++ R LEQ++ L +L+ R E D ++ R
Sbjct: 67 ASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQL-RAKEPTKLADVYQAELRELRL 125
Query: 98 RVRDLEAERARLERQGTEAQRALDEFRSKYENECECQLLLKEMLERLNKEADEALLHNLR 157
R+ L A ARLE + + L R K ++E +L + L +EADEA L L
Sbjct: 126 RLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEATLARLD 185
Query: 158 LQLEAQFLQDDISAAKDRHKKNLLEVQTYISILQQIIHTTPPASIVTSGMREEKLLTE-- 215
L+ + + L+++I + H++ + E+Q ++ Q + +T+ ++E + E
Sbjct: 186 LERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKPDLTAALKEIRTQYEAM 245
Query: 216 ------------------------REVAALRSQLEEGREVLSHLQAQRVELQAQTTT--- 248
R LR E + LQ+ +L++ T
Sbjct: 246 ASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTNES 305
Query: 249 LEQAIKSAHECYDDEIQLYNEQIETLRKEIEETERVLEKSSYDCRQLAVAQQTLKNELDR 308
LE+ ++ E + E Y E + L +E + + + + + + L + L E+
Sbjct: 306 LERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALDIEIAT 365
Query: 309 YHRIIEIEGNRLTSAFIETPIPLFTQSH-----GVSLSTGSGGKDLTRALQDIT 357
Y +++E E NR+T IP+ T S+ G S G K +TR L+ +T
Sbjct: 366 YRKLLEGEENRIT-------IPVQTFSNLQIRGGKSTKDGENHK-VTRYLKSLT 411
>gi|14917115 keratin 31 [Homo sapiens]
Length = 416
Score = 79.3 bits (194), Expect = 1e-14
Identities = 69/321 (21%), Positives = 144/321 (44%), Gaps = 31/321 (9%)
Query: 33 EGWAGATSLAALQGLGERVAAHVQRARALEQRHAGLRRQL-DAFQRLGELAGPE-DALAR 90
EG + +Q L +R+A+++++ R LE+ +A L + + Q+ L P + +
Sbjct: 49 EGSFNGSEKETMQFLNDRLASYLEKVRQLERDNAELENLIRERSQQQEPLLCPSYQSYFK 108
Query: 91 QVESNRQRVRDLEAERARLERQGTEAQRALDEFRSKYENECECQLLLKEMLERLNKEADE 150
+E +Q++ ++E ARL Q A+ A D+FR+KY+ E + L++ + L + DE
Sbjct: 109 TIEELQQKILCTKSENARLVVQIDNAKLAADDFRTKYQTELSLRQLVESDINGLRRILDE 168
Query: 151 ALLHNLRLQLEAQFLQDDISAAKDRHKKNL------------LEVQTYISI-LQQIIHTT 197
L L+ + + L++++ K H++ + +EV ++ L ++++ T
Sbjct: 169 LTLCKSDLEAQVESLKEELLCLKSNHEQEVNTLRCQLGDRLNVEVDAAPTVDLNRVLNET 228
Query: 198 PP--ASIVTSGMREEKLLTEREVAALRSQLEEGREVLSHLQAQRVELQAQTTTLEQAIKS 255
++V + RE + + L Q+ E L QA+ +EL+ LE +++
Sbjct: 229 RSQYEALVETNRREVEQWFTTQTEELNKQVVSSSEQLQSYQAEIIELRRTVNALEIELQA 288
Query: 256 AHEC--------------YDDEIQLYNEQIETLRKEIEETERVLEKSSYDCRQLAVAQQT 301
H Y ++ I + ++ E LE+ + + + L +
Sbjct: 289 QHNLRDSLENTLTESEARYSSQLSQVQSLITNVESQLAEIRSDLERQNQEYQVLLDVRAR 348
Query: 302 LKNELDRYHRIIEIEGNRLTS 322
L+ E++ Y ++E E L S
Sbjct: 349 LECEINTYRSLLESEDCNLPS 369
>gi|4503979 glial fibrillary acidic protein isoform 1 [Homo sapiens]
Length = 432
Score = 77.8 bits (190), Expect = 3e-14
Identities = 77/338 (22%), Positives = 143/338 (42%), Gaps = 37/338 (10%)
Query: 38 ATSLAALQGLGERVAAHVQRARALEQRHAGLRRQLDAFQRLGELAGPEDALARQVESNRQ 97
A+ A + L +R A+++++ R LEQ++ L +L+ R E D ++ R
Sbjct: 67 ASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQL-RAKEPTKLADVYQAELRELRL 125
Query: 98 RVRDLEAERARLERQGTEAQRALDEFRSKYENECECQLLLKEMLERLNKEADEALLHNLR 157
R+ L A ARLE + + L R K ++E +L + L +EADEA L L
Sbjct: 126 RLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEATLARLD 185
Query: 158 LQLEAQFLQDDISAAKDRHKKNLLEVQTYISILQQIIHTTPPASIVTSGMREEKLLTE-- 215
L+ + + L+++I + H++ + E+Q ++ Q + +T+ ++E + E
Sbjct: 186 LERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKPDLTAALKEIRTQYEAM 245
Query: 216 ------------------------REVAALRSQLEEGREVLSHLQAQRVELQAQTTT--- 248
R LR E + LQ+ +L++ T
Sbjct: 246 ASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTNES 305
Query: 249 LEQAIKSAHECYDDEIQLYNEQIETLRKEIEETERVLEKSSYDCRQLAVAQQTLKNELDR 308
LE+ ++ E + E Y E + L +E + + + + + + L + L E+
Sbjct: 306 LERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALDIEIAT 365
Query: 309 YHRIIEIEGNRLTSAFIETPIPLFT--QSHGVSLSTGS 344
Y +++E E NR+T P+ F+ Q SL T S
Sbjct: 366 YRKLLEGEENRIT-----IPVQTFSNLQIRETSLDTKS 398
>gi|15431310 keratin 14 [Homo sapiens]
Length = 472
Score = 77.8 bits (190), Expect = 3e-14
Identities = 70/327 (21%), Positives = 152/327 (46%), Gaps = 37/327 (11%)
Query: 34 GWAGATSL------AALQGLGERVAAHVQRARALEQRHAGLRRQLDAFQRLGELAGPED- 86
G+AG L +Q L +R+A+++ + RALE+ +A L ++ + + A +D
Sbjct: 103 GFAGGDGLLVGSEKVTMQNLNDRLASYLDKVRALEEANADLEVKIRDWYQRQRPAEIKDY 162
Query: 87 -ALARQVESNRQRVRDLEAERARLERQGTEAQRALDEFRSKYENECECQLLLKEMLERLN 145
+ +E R ++ + A + Q A+ A D+FR+KYE E ++ ++ + L
Sbjct: 163 SPYFKTIEDLRNKILTATVDNANVLLQIDNARLAADDFRTKYETELNLRMSVEADINGLR 222
Query: 146 KEADEALLHNLRLQLEAQFLQDDISAAKDRHKKNLLEVQTYISILQQIIHTTPPA---SI 202
+ DE L L+++ + L+++++ K H++ + ++ + + P S
Sbjct: 223 RVLDELTLARADLEMQIESLKEELAYLKKNHEEEMNALRGQVGGDVNVEMDAAPGVDLSR 282
Query: 203 VTSGMRE--EKLLTE-----------------REVAALRSQLEEGREVLSHL----QAQR 239
+ + MR+ EK+ + REVA ++ G+ +S L Q
Sbjct: 283 ILNEMRDQYEKMAEKNRKDAEEWFFTKTEELNREVATNSELVQSGKSEISELRRTMQNLE 342
Query: 240 VELQAQTT---TLEQAIKSAHECYDDEIQLYNEQIETLRKEIEETERVLEKSSYDCRQLA 296
+ELQ+Q + +LE +++ Y ++ E I ++ +++ + +E+ + + + L
Sbjct: 343 IELQSQLSMKASLENSLEETKGRYCMQLAQIQEMIGSVEEQLAQLRCEMEQQNQEYKILL 402
Query: 297 VAQQTLKNELDRYHRIIEIEGNRLTSA 323
+ L+ E+ Y R++E E L+S+
Sbjct: 403 DVKTRLEQEIATYRRLLEGEDAHLSSS 429
>gi|114431246 keratin 25D [Homo sapiens]
Length = 464
Score = 76.3 bits (186), Expect = 9e-14
Identities = 86/395 (21%), Positives = 158/395 (40%), Gaps = 50/395 (12%)
Query: 31 ADEGWAGATSLAALQGLGERVAAHVQRARALEQRHAGLRRQLDAFQRL---GELAGPEDA 87
++ G +Q L +R+A+++ RALE+ +A L R++ + G G +
Sbjct: 77 SEGGLLSGNEKVTMQNLNDRLASYLDNVRALEEANAELERKIKGWYEKYGPGSCRGLDHD 136
Query: 88 LARQ---VESNRQRVRDLEAERARLERQGTEAQRALDEFRSKYENECECQLLLKEMLERL 144
+R +E + ++ A + Q A+ A D+FR KYENE ++ + L
Sbjct: 137 YSRYHLTIEDLKNKIISSTTTNANVILQIDNARLAADDFRLKYENELTLHQNVEADINGL 196
Query: 145 NKEADEALLHNLRLQLEAQFLQDDISAAKDRHKKNLLEVQTYISILQQIIHTTPPA---S 201
+ DE L +L+ + L ++++ K H++ + +Q + P +
Sbjct: 197 RRVLDELTLCRTDQELQYESLSEEMTYLKKNHEEEMKALQCAAGGNVNVEMNAAPGVDLA 256
Query: 202 IVTSGMREE-KLLTERE-------------------------VAALRSQLEEGREVLSHL 235
++ + MR E + L E+ RSQL E R L L
Sbjct: 257 VLLNNMRAEYEALAEQNRKDAEAWFNEKSASLQQQISHDSGAATFARSQLTEMRRTLQTL 316
Query: 236 QAQRVELQAQTTTLEQAIKSAHECYDDEIQLYNEQIETLRKEIEETERVLEKSSYDCRQL 295
+ Q L A +LE ++ Y ++ QI L +++ + E + L
Sbjct: 317 EIQLQSLMATKHSLECSLTETESNYCTQLAQIQAQIGALEEQLHQVRTETEGQKLEYEHL 376
Query: 296 AVAQQTLKNELDRYHRIIEIEGNRLTSAFIETPIPLFTQSHGVSLSTGSGGKDLTRALQD 355
+ L+ E++ Y R+I+ +GN + ++ G S S G+ KDL++
Sbjct: 377 LDVKVHLEKEIETYCRLIDGDGNSCSK----------SKGFG-SGSPGNSSKDLSKTTLV 425
Query: 356 ITAAK---PRQKALPKNVPRRKEIITKDKTNGALE 387
T + R K L + +E +K TNG E
Sbjct: 426 KTVVEELDQRGKVLSSRIHSIEEKTSK-MTNGKTE 459
>gi|125490370 type I hair keratin KA36 [Homo sapiens]
Length = 431
Score = 75.5 bits (184), Expect = 1e-13
Identities = 70/321 (21%), Positives = 142/321 (44%), Gaps = 31/321 (9%)
Query: 32 DEGWAGATSLAALQGLGERVAAHVQRARALEQRHAGL--RRQLDAFQRLGELAGPEDALA 89
++G + +Q L +R+A+++++ R+LE+ +A L R Q Q + +
Sbjct: 81 EDGVFTSNEKETMQFLNDRLASYLEKVRSLEETNAELESRIQEQCEQDIPMVCPDYQRYF 140
Query: 90 RQVESNRQRVRDLEAERARLERQGTEAQRALDEFRSKYENECECQLLLKEMLERLNKEAD 149
+E +Q++ +AE +RL Q + A D+F+SKYE+E + LL+ + L+ +
Sbjct: 141 NTIEDLQQKILCTKAENSRLAVQLDNCKLATDDFKSKYESELSLRQLLEADISSLHGILE 200
Query: 150 EALLHNLRLQLEAQFLQDDISAAKDRHKKNLLEVQTYISILQQIIHTTPPASIVTSGMRE 209
E L L+ + L++D+ K H++ + ++ + + T P + + E
Sbjct: 201 ELTLCKSDLEAHVESLKEDLLCLKKNHEEEVNLLREQLGDRLSVELDTAPTLDLNRVLDE 260
Query: 210 EKLLTEREVAALRSQLEE---------GREVLSHLQ-----------------AQRVELQ 243
+ E +A R + EE ++ LS + A +ELQ
Sbjct: 261 MRCQCETVLANNRREAEEWLAVQTEELNQQQLSSAEQLQGCQMEILELKRTASALEIELQ 320
Query: 244 AQ---TTTLEQAIKSAHECYDDEIQLYNEQIETLRKEIEETERVLEKSSYDCRQLAVAQQ 300
AQ T +LE + Y ++ I+ L ++ E LE+ + + + L +
Sbjct: 321 AQQSLTESLECTVAETEAQYSSQLAQIQCLIDNLENQLAEIRCDLERQNQEYQVLLDVKA 380
Query: 301 TLKNELDRYHRIIEIEGNRLT 321
L+ E++ Y +++ E +RL+
Sbjct: 381 RLEGEINTYWGLLDSEDSRLS 401
>gi|195972866 keratin 10 [Homo sapiens]
Length = 584
Score = 75.5 bits (184), Expect = 1e-13
Identities = 67/321 (20%), Positives = 144/321 (44%), Gaps = 34/321 (10%)
Query: 32 DEGWAGATSLAALQGLGERVAAHVQRARALEQRHAGLRRQL-DAFQRLGEL--AGPED-- 86
D G +Q L +R+A+++ + RALE+ + L ++ + +++ G P D
Sbjct: 138 DGGLLSGNEKVTMQNLNDRLASYLDKVRALEESNYELEGKIKEWYEKHGNSHQGEPRDYS 197
Query: 87 ALARQVESNRQRVRDLEAERARLERQGTEAQRALDEFRSKYENECECQLLLKEMLERLNK 146
+ ++ + ++ +L + A + Q A+ A D+FR KYENE + ++ + L +
Sbjct: 198 KYYKTIDDLKNQILNLTTDNANILLQIDNARLAADDFRLKYENEVALRQSVEADINGLRR 257
Query: 147 EADEALLHNLRLQLEAQFLQDDISAAKDRHKKNLLEVQTYISILQQIIHTTPPASIVT-- 204
DE L L+++ + L ++++ K H++ + +++ + + P +T
Sbjct: 258 VLDELTLTKADLEMQIESLTEELAYLKKNHEEEMKDLRNVSTGDVNVEMNAAPGVDLTQL 317
Query: 205 -SGMREE---------------------KLLTE--REVAALRSQLEEGREVLSHLQAQRV 240
+ MR + +L TE + + S E E+ ++QA +
Sbjct: 318 LNNMRSQYEQLAEQNRKDAEAWFNEKSKELTTEIDNNIEQISSYKSEITELRRNVQALEI 377
Query: 241 ELQAQTT---TLEQAIKSAHECYDDEIQLYNEQIETLRKEIEETERVLEKSSYDCRQLAV 297
ELQ+Q +LE ++ Y ++ QI L +++++ E + + +QL
Sbjct: 378 ELQSQLALKQSLEASLAETEGRYCVQLSQIQAQISALEEQLQQIRAETECQNTEYQQLLD 437
Query: 298 AQQTLKNELDRYHRIIEIEGN 318
+ L+NE+ Y ++E EG+
Sbjct: 438 IKIRLENEIQTYRSLLEGEGS 458
>gi|4504919 keratin 8 [Homo sapiens]
Length = 483
Score = 75.1 bits (183), Expect = 2e-13
Identities = 67/335 (20%), Positives = 146/335 (43%), Gaps = 32/335 (9%)
Query: 44 LQGLGERVAAHVQRARALEQRHAGLRRQLDAFQRLGELAGPEDALARQVESN-RQRVRDL 102
++ L + A+ + + R LEQ++ L + Q+ D + +N R+++ L
Sbjct: 95 IKTLNNKFASFIDKVRFLEQQNKMLETKWSLLQQQKTARSNMDNMFESYINNLRRQLETL 154
Query: 103 EAERARLERQGTEAQRALDEFRSKYENECECQLLLKEMLERLNKEADEALLHNLRLQLEA 162
E+ +LE + Q +++F++KYE+E + ++ + K+ DEA ++ + L+
Sbjct: 155 GQEKLKLEAELGNMQGLVEDFKNKYEDEINKRTEMENEFVLIKKDVDEAYMNKVELESRL 214
Query: 163 QFLQDDISAAKDRHKKNLLEVQTYISILQQIIHTTPPASIVTSGMREEKLLTEREVA--- 219
+ L D+I+ + +++ + E+Q+ IS ++ S+ + E ++A
Sbjct: 215 EGLTDEINFLRQLYEEEIRELQSQISDTSVVLSMDNSRSLDMDSIIAEVKAQYEDIANRS 274
Query: 220 ---------------------------ALRSQLEEGREVLSHLQAQRVELQAQTTTLEQA 252
++++ E +S LQA+ L+ Q +LE A
Sbjct: 275 RAEAESMYQIKYEELQSLAGKHGDDLRRTKTEISEMNRNISRLQAEIEGLKGQRASLEAA 334
Query: 253 IKSAHECYDDEIQLYNEQIETLRKEIEETERVLEKSSYDCRQLAVAQQTLKNELDRYHRI 312
I A + + I+ N ++ L ++ ++ + + + ++L + L E+ Y ++
Sbjct: 335 IADAEQRGELAIKDANAKLSELEAALQRAKQDMARQLREYQELMNVKLALDIEIATYRKL 394
Query: 313 IEIEGNRLTSAFIETPIPLFTQS-HGVSLSTGSGG 346
+E E +RL S I T S + LS+ GG
Sbjct: 395 LEGEESRLESGMQNMSIHTKTTSGYAGGLSSAYGG 429
>gi|4504927 keratin 36 [Homo sapiens]
Length = 467
Score = 75.1 bits (183), Expect = 2e-13
Identities = 63/319 (19%), Positives = 137/319 (42%), Gaps = 31/319 (9%)
Query: 33 EGWAGATSLAALQGLGERVAAHVQRARALEQRHAGLRRQLDAFQ--RLGELAGPEDALAR 90
EG + +Q L +R+A ++++ R LE+ +A L ++ + ++ + + +
Sbjct: 86 EGSFNGSEKETMQFLNDRLANYLEKVRQLERENAELESRIQEWYEFQIPYICPDYQSYFK 145
Query: 91 QVESNRQRVRDLEAERARLERQGTEAQRALDEFRSKYENECECQLLLKEMLERLNKEADE 150
+E +Q++ ++E ARL Q A+ A D+FR+KYE E + L++ + L + DE
Sbjct: 146 TIEDFQQKILLTKSENARLVLQIDNAKLAADDFRTKYETELSLRQLVEADINGLRRILDE 205
Query: 151 ALLHNLRLQLEAQFLQDDISAAKDRHKKNLLEVQTYI-SILQQIIHTTPPA--------- 200
L L+ + + L++++ K H++ + ++ + L + PP
Sbjct: 206 LTLCKADLEAQVESLKEELMCLKKNHEEEVSVLRCQLGDRLNVEVDAAPPVDLNKILEDM 265
Query: 201 -----SIVTSGMREEKLLTEREVAALRSQLEEGREVLSHLQAQRVELQAQTTTLEQAIKS 255
++V + R+ + + L Q+ E L Q + +EL+ LE +++
Sbjct: 266 RCQYEALVENNRRDVEAWFNTQTEELNQQVVSSSEQLQCCQTEIIELRRTVNALEIELQA 325
Query: 256 AHEC--------------YDDEIQLYNEQIETLRKEIEETERVLEKSSYDCRQLAVAQQT 301
H Y ++ I + ++ E LE+ + + + L +
Sbjct: 326 QHSMRNSLESTLAETEARYSSQLAQMQCLISNVEAQLSEIRCDLERQNQEYQVLLDVKAR 385
Query: 302 LKNELDRYHRIIEIEGNRL 320
L+ E+ Y ++E E +L
Sbjct: 386 LEGEIATYRHLLEGEDCKL 404
>gi|4557701 keratin 17 [Homo sapiens]
Length = 432
Score = 73.9 bits (180), Expect = 4e-13
Identities = 70/322 (21%), Positives = 148/322 (45%), Gaps = 35/322 (10%)
Query: 33 EGWAGATSLAALQGLGERVAAHVQRARALEQRHAGLRRQL-DAFQRLGELAGPEDALA-- 89
+G A +Q L +R+A+++ + RALE+ + L ++ D +QR + GP +
Sbjct: 77 DGLLAGGEKATMQNLNDRLASYLDKVRALEEANTELEVKIRDWYQR--QAPGPARDYSQY 134
Query: 90 -RQVESNRQRVRDLEAERARLERQGTEAQRALDEFRSKYENECECQLLLKEMLERLNKEA 148
R +E + ++ + A + Q A+ A D+FR+K+E E +L ++ + L +
Sbjct: 135 YRTIEELQNKILTATVDNANILLQIDNARLAADDFRTKFETEQALRLSVEADINGLRRVL 194
Query: 149 DEALLHNLRLQLEAQFLQDDISAAKDRHKKNLLEVQTYISILQQIIHTTPPA---SIVTS 205
DE L L+++ + L+++++ K H++ + ++ + + P S + +
Sbjct: 195 DELTLARADLEMQIENLKEELAYLKKNHEEEMNALRGQVGGEINVEMDAAPGVDLSRILN 254
Query: 206 GMRE--EKLLTE-----------------REVAALRSQLEEGREVLSHL----QAQRVEL 242
MR+ EK+ + REVA ++ G+ +S L QA +EL
Sbjct: 255 EMRDQYEKMAEKNRKDAEDWFFSKTEELNREVATNSELVQSGKSEISELRRTMQALEIEL 314
Query: 243 QAQTT---TLEQAIKSAHECYDDEIQLYNEQIETLRKEIEETERVLEKSSYDCRQLAVAQ 299
Q+Q + +LE + Y ++ I ++ +++ + +E+ + + + L +
Sbjct: 315 QSQLSMKASLEGNLAETENRYCVQLSQIQGLIGSVEEQLAQLRCEMEQQNQEYKILLDVK 374
Query: 300 QTLKNELDRYHRIIEIEGNRLT 321
L+ E+ Y R++E E LT
Sbjct: 375 TRLEQEIATYRRLLEGEDAHLT 396
>gi|131412228 keratin 13 isoform b [Homo sapiens]
Length = 420
Score = 73.9 bits (180), Expect = 4e-13
Identities = 67/315 (21%), Positives = 136/315 (43%), Gaps = 32/315 (10%)
Query: 32 DEGWAGATSLAALQGLGERVAAHVQRARALEQRHAGLRRQLDAFQRLGELAGPEDALA-- 89
D G +Q L +R+A+++++ RALE+ +A L ++ + A PE +
Sbjct: 96 DGGLLTGNEKITMQNLNDRLASYLEKVRALEEANADLEVKIRDWHLKQSPASPERDYSPY 155
Query: 90 -RQVESNRQRVRDLEAERARLERQGTEAQRALDEFRSKYENECECQLLLKEMLERLNKEA 148
+ +E R ++ E R+ + A+ A D+FR KYENE + ++ + L +
Sbjct: 156 YKTIEELRDKILTATIENNRVILEIDNARLAADDFRLKYENELALRQSVEADINGLRRVL 215
Query: 149 DEALLHNLRLQLEAQFLQDDISAAKDRHKKNLLEVQT-YISILQQIIHTTPPASI--VTS 205
DE L L+++ + L ++++ K H++ + E + + + TP + V +
Sbjct: 216 DELTLSKTDLEMQIESLNEELAYMKKNHEEEMKEFSNQVVGQVNVEMDATPGIDLTRVLA 275
Query: 206 GMREE-KLLTER----------------------EVAALRSQLEEGREVLSHLQAQRVEL 242
MRE+ + + ER A +++ E E+ LQ +EL
Sbjct: 276 EMREQYEAMAERNRRDAEEWFHAKSAELNKEVSTNTAMIQTSKTEITELRRTLQGLEIEL 335
Query: 243 QAQTTT---LEQAIKSAHECYDDEIQLYNEQIETLRKEIEETERVLEKSSYDCRQLAVAQ 299
Q+Q + LE + Y ++Q I ++ ++ E +E + + + L +
Sbjct: 336 QSQLSMKAGLENTVAETECRYALQLQQIQGLISSIEAQLSELRSEMECQNQEYKMLLDIK 395
Query: 300 QTLKNELDRYHRIIE 314
L+ E+ Y ++E
Sbjct: 396 TRLEQEIATYRSLLE 410
>gi|131412225 keratin 13 isoform a [Homo sapiens]
Length = 458
Score = 73.9 bits (180), Expect = 4e-13
Identities = 67/315 (21%), Positives = 136/315 (43%), Gaps = 32/315 (10%)
Query: 32 DEGWAGATSLAALQGLGERVAAHVQRARALEQRHAGLRRQLDAFQRLGELAGPEDALA-- 89
D G +Q L +R+A+++++ RALE+ +A L ++ + A PE +
Sbjct: 96 DGGLLTGNEKITMQNLNDRLASYLEKVRALEEANADLEVKIRDWHLKQSPASPERDYSPY 155
Query: 90 -RQVESNRQRVRDLEAERARLERQGTEAQRALDEFRSKYENECECQLLLKEMLERLNKEA 148
+ +E R ++ E R+ + A+ A D+FR KYENE + ++ + L +
Sbjct: 156 YKTIEELRDKILTATIENNRVILEIDNARLAADDFRLKYENELALRQSVEADINGLRRVL 215
Query: 149 DEALLHNLRLQLEAQFLQDDISAAKDRHKKNLLEVQT-YISILQQIIHTTPPASI--VTS 205
DE L L+++ + L ++++ K H++ + E + + + TP + V +
Sbjct: 216 DELTLSKTDLEMQIESLNEELAYMKKNHEEEMKEFSNQVVGQVNVEMDATPGIDLTRVLA 275
Query: 206 GMREE-KLLTER----------------------EVAALRSQLEEGREVLSHLQAQRVEL 242
MRE+ + + ER A +++ E E+ LQ +EL
Sbjct: 276 EMREQYEAMAERNRRDAEEWFHAKSAELNKEVSTNTAMIQTSKTEITELRRTLQGLEIEL 335
Query: 243 QAQTTT---LEQAIKSAHECYDDEIQLYNEQIETLRKEIEETERVLEKSSYDCRQLAVAQ 299
Q+Q + LE + Y ++Q I ++ ++ E +E + + + L +
Sbjct: 336 QSQLSMKAGLENTVAETECRYALQLQQIQGLISSIEAQLSELRSEMECQNQEYKMLLDIK 395
Query: 300 QTLKNELDRYHRIIE 314
L+ E+ Y ++E
Sbjct: 396 TRLEQEIATYRSLLE 410
>gi|55956899 keratin 9 [Homo sapiens]
Length = 623
Score = 73.6 bits (179), Expect = 6e-13
Identities = 64/315 (20%), Positives = 137/315 (43%), Gaps = 32/315 (10%)
Query: 32 DEGWAGATSLAALQGLGERVAAHVQRARALEQRHAGLRRQL-DAFQRLGELAGPED--AL 88
D G A + +Q L R+A+++ + +ALE+ + L ++ D + + G A ++
Sbjct: 145 DGGILTANEKSTMQELNSRLASYLDKVQALEEANNDLENKIQDWYDKKGPAAIQKNYSPY 204
Query: 89 ARQVESNRQRVRDLEAERARLERQGTEAQRALDEFRSKYENECECQLLLKEMLERLNKEA 148
++ + ++ DL + + LD+FR K+E E + + + L +
Sbjct: 205 YNTIDDLKDQIVDLTVGNNKTLLDIDNTRMTLDDFRIKFEMEQNLRQGVDADINGLRQVL 264
Query: 149 DEALLHNLRLQLEAQFLQDDISAAKDRHKKNLLEVQTYISILQQIIHTTPPASIVTSGMR 208
D + L+++ + LQ+++ A K HK+ + ++ S + P +T +
Sbjct: 265 DNLTMEKSDLEMQYETLQEELMALKKNHKEEMSQLTGQNSGDVNVEINVAPGKDLTKTLN 324
Query: 209 EEKLLTEREVAALRSQLEE----------------GREVLSH----------LQAQRVEL 242
+ + E+ +A R +E G+EV S +Q +EL
Sbjct: 325 DMRQEYEQLIAKNRKDIENQYETQITQIEHEVSSSGQEVQSSAKEVTQLRHGVQELEIEL 384
Query: 243 QAQTT---TLEQAIKSAHECYDDEIQLYNEQIETLRKEIEETERVLEKSSYDCRQLAVAQ 299
Q+Q + LE++++ Y ++Q+ EQI L +I + + +E + + L +
Sbjct: 385 QSQLSKKAALEKSLEDTKNRYCGQLQMIQEQISNLEAQITDVRQEIECQNQEYSLLLSIK 444
Query: 300 QTLKNELDRYHRIIE 314
L+ E++ YH ++E
Sbjct: 445 MRLEKEIETYHNLLE 459
>gi|194018511 keratin 77 [Homo sapiens]
Length = 578
Score = 73.6 bits (179), Expect = 6e-13
Identities = 69/333 (20%), Positives = 151/333 (45%), Gaps = 34/333 (10%)
Query: 47 LGERVAAHVQRARALEQRHAGLRRQLDAFQRLGELAGP---EDALARQVESNRQRVRDLE 103
L + A+ + + R LEQ++ L+ + + Q++ G E L + R++V L
Sbjct: 171 LNNKFASFIDKVRFLEQQNQVLQTKWELLQQVNTSTGTNNLEPLLENYIGDLRRQVDLLS 230
Query: 104 AERARLERQGTEAQRALDEFRSKYENECECQLLLKEMLERLNKEADEALLHNLRLQLEAQ 163
AE+ R + Q +++++SKYE+E + + L K+ D A + + L+
Sbjct: 231 AEQMRQNAEVRSMQDVVEDYKSKYEDEINKRTGSENDFVVLKKDVDAAYVSKVDLESRVD 290
Query: 164 FLQDDISAAKDRHKKNLLEVQTYISILQQII-----HTTPPASIVTSGMREEKLLTER-- 216
L +++ K L +VQT+IS I+ + SI+ + + +L+ +R
Sbjct: 291 TLTGEVNFLKYLFLTELSQVQTHISDTNVILSMDNNRSLDLDSIIDAVRTQYELIAQRSK 350
Query: 217 -EVAAL----------------------RSQLEEGREVLSHLQAQRVELQAQTTTLEQAI 253
E AL + ++ E + LQA+ ++ Q ++ I
Sbjct: 351 DEAEALYQTKYQELQITAGRHGDDLKNSKMEIAELNRTVQRLQAEISNVKKQIEQMQSLI 410
Query: 254 KSAHECYDDEIQLYNEQIETLRKEIEETERVLEKSSYDCRQLAVAQQTLKNELDRYHRII 313
A E + +Q ++++ L + +++++ L + D + + + +L E+ Y +++
Sbjct: 411 SDAEERGEQALQDAWQKLQDLEEALQQSKEELARLLRDYQAMLGVKLSLDVEIATYRQLL 470
Query: 314 EIEGNRLTSAFIETPIPLFTQSHGVSLSTGSGG 346
E E +R+ S +++ + + Q+ VS++ G+GG
Sbjct: 471 EGEESRM-SGELQSHVSISVQNSQVSVNGGAGG 502
>gi|148277620 type I hair keratin KA35 [Homo sapiens]
Length = 491
Score = 72.0 bits (175), Expect = 2e-12
Identities = 64/302 (21%), Positives = 134/302 (44%), Gaps = 31/302 (10%)
Query: 44 LQGLGERVAAHVQRARALEQRHAGLRRQL--DAFQRLGELAGPEDALARQVESNRQRVRD 101
+Q L ER+A ++Q+ R LE+ +A L ++ ++ + L L + +E +Q++
Sbjct: 100 MQILNERLANYLQKVRMLERENAELESKIQEESNKELPVLCPDYLSYYTTIEELQQKILC 159
Query: 102 LEAERARLERQGTEAQRALDEFRSKYENECECQLLLKEMLERLNKEADEALLHNLRLQLE 161
+AE +RL Q + D+ R+KYE E + L++ L + + L L+ +
Sbjct: 160 TKAENSRLVSQIDNTKLTADDLRAKYEAEVSLRQLVESDANGLKQILNVLTLGKADLEAQ 219
Query: 162 AQFLQDDISAAKDRHKKNLLEVQTYISILQQIIHTTPPASIVTSGMREEKLLTEREVAAL 221
Q L++++ K+ HK+ + +Q + I T P++ + ++E + E +
Sbjct: 220 VQSLKEELLCLKNNHKEEINSLQCQLGERLDIEVTAAPSADLNQVLQEMRCQYEPIMETN 279
Query: 222 RSQLEE---------GREVLSHLQAQR------VELQAQTTTLEQAIKSAHECYDDEIQL 266
R +E+ ++V++ Q Q+ +EL+ TLE +++ H D + +
Sbjct: 280 RKDVEQWFNTQIEELNQQVVTSSQQQQCCQKEIIELRRSVNTLEVELQAQHRMRDSQECI 339
Query: 267 YNEQ--------------IETLRKEIEETERVLEKSSYDCRQLAVAQQTLKNELDRYHRI 312
E I+ L ++ E LE+ + + L + L+ E+ Y +
Sbjct: 340 LTETEARYTALLTQIQSLIDNLEAQLAEIRCALERQNQEYEILLDVKSRLECEITTYRSL 399
Query: 313 IE 314
+E
Sbjct: 400 LE 401
>gi|14249342 internexin neuronal intermediate filament protein,
alpha [Homo sapiens]
Length = 499
Score = 72.0 bits (175), Expect = 2e-12
Identities = 68/315 (21%), Positives = 134/315 (42%), Gaps = 37/315 (11%)
Query: 44 LQGLGERVAAHVQRARALEQRHAGLRRQLDAF-QRLGELAGPEDALARQVESNRQRVRDL 102
LQGL +R A +++ LE ++ L +L A QR E + + R++ R ++ +
Sbjct: 98 LQGLNDRFAVFIEKVHQLETQNRALEAELAALRQRHAEPSRVGELFQRELRDLRAQLEEA 157
Query: 103 EAERAR--LERQGTEAQRALDEFRSKYENECECQLLLKEMLERLNKEADEALLHNLRLQL 160
+ R++ LER G + + R++ E E + + L+ ++ D A L L L+
Sbjct: 158 SSARSQALLERDGLAEE--VQRLRARCEEESRGREGAERALKAQQRDVDGATLARLDLEK 215
Query: 161 EAQFLQDDISAAKDRHKKNLLEVQTYISILQQI---IHTTPPASIVTSGMREEKLLTE-- 215
+ + L D+++ + H + + E+ + Q + T +TS +RE + E
Sbjct: 216 KVESLLDELAFVRQVHDEEVAELLATLQASSQAAAEVDVTVAKPDLTSALREIRAQYESL 275
Query: 216 ------------------------REVAALRSQLEEGREVLSHLQAQRVE---LQAQTTT 248
R A+R+ EE E LQA+ +E L+ +
Sbjct: 276 AAKNLQSAEEWYKSKFANLNEQAARSTEAIRASREEIHEYRRQLQARTIEIEGLRGANES 335
Query: 249 LEQAIKSAHECYDDEIQLYNEQIETLRKEIEETERVLEKSSYDCRQLAVAQQTLKNELDR 308
LE+ I E + E+ Y + I L ++ T+ + + + + L + L E+
Sbjct: 336 LERQILELEERHSAEVAGYQDSIGQLENDLRNTKSEMARHLREYQDLLNVKMALDIEIAA 395
Query: 309 YHRIIEIEGNRLTSA 323
Y +++E E R +++
Sbjct: 396 YRKLLEGEETRFSTS 410
>gi|62414289 vimentin [Homo sapiens]
Length = 466
Score = 70.9 bits (172), Expect = 4e-12
Identities = 70/319 (21%), Positives = 135/319 (42%), Gaps = 35/319 (10%)
Query: 44 LQGLGERVAAHVQRARALEQRHAGLRRQLDAFQRLGELAGPEDALARQVESNRQRVRDLE 103
LQ L +R A ++ + R LEQ++ L +L+ + G+ + D ++ R++V L
Sbjct: 107 LQELNDRFANYIDKVRFLEQQNKILLAELEQLKGQGK-SRLGDLYEEEMRELRRQVDQLT 165
Query: 104 AERARLERQGTEAQRALDEFRSKYENECECQLLLKEMLERLNKEADEALLHNLRLQLEAQ 163
++AR+E + + R K + E + + L+ ++ D A L L L+ + +
Sbjct: 166 NDKARVEVERDNLAEDIMRLREKLQEEMLQREEAENTLQSFRQDVDNASLARLDLERKVE 225
Query: 164 FLQDDISAAKDRHKKNLLEVQTYISILQQIIHTTPPASIVTSGMREEKLLTEREVA---- 219
LQ++I+ K H++ + E+Q I I +T+ +R+ + E A
Sbjct: 226 SLQEEIAFLKKLHEEEIQELQAQIQEQHVQIDVDVSKPDLTAALRDVRQQYESVAAKNLQ 285
Query: 220 ----------------------ALRSQLEEGREVLSHLQAQRVELQAQTTT---LEQAIK 254
ALR +E E +Q+ E+ A T LE+ ++
Sbjct: 286 EAEEWYKSKFADLSEAANRNNDALRQAKQESTEYRRQVQSLTCEVDALKGTNESLERQMR 345
Query: 255 SAHECYDDEIQLYNEQIETLRKEIEETERVLEKSSYDCRQLAVAQQTLKNELDRYHRIIE 314
E + E Y + I L+ EI+ + + + + + L + L E+ Y +++E
Sbjct: 346 EMEENFAVEAANYQDTIGRLQDEIQNMKEEMARHLREYQDLLNVKMALDIEIATYRKLLE 405
Query: 315 IEGNRLTSAFIETPIPLFT 333
E +R I P+P F+
Sbjct: 406 GEESR-----ISLPLPNFS 419
>gi|55770882 keratin 37 [Homo sapiens]
Length = 449
Score = 70.5 bits (171), Expect = 5e-12
Identities = 74/338 (21%), Positives = 143/338 (42%), Gaps = 39/338 (11%)
Query: 30 PADEGWAGATSLAALQG--------LGERVAAHVQRARALEQRHAGLRRQLDAFQRLGEL 81
P + G GA L G L +R+A ++++ R LEQ +A L L + E
Sbjct: 86 PGNIGICGAYGKNTLNGHEKETMKFLNDRLANYLEKVRQLEQENAELETTLLERSKCHES 145
Query: 82 AGPED--ALARQVESNRQRVRDLEAERARLERQGTEAQRALDEFRSKYENECECQLLLKE 139
D + R +E +Q++ +AE ARL Q A+ A D+FR K E+E L++
Sbjct: 146 TVCPDYQSYFRTIEELQQKILCSKAENARLIVQIDNAKLAADDFRIKLESERSLHQLVEA 205
Query: 140 MLERLNKEADEALLHNLRLQLEAQFLQDDISAAKDRHKKNL--------------LEVQT 185
K D+A L L+ + + L+++ + K H++ + L+++
Sbjct: 206 DKCGTQKLLDDATLAKADLEAQQESLKEEQLSLKSNHEQEVKILRSQLGEKFRIELDIEP 265
Query: 186 YISILQQI--IHTTPPASIVTS-------------GMREEKLLTEREVAALRSQLEEGRE 230
I + + + + A + T+ G+ + + E+ +S++ E R
Sbjct: 266 TIDLNRVLGEMRAQYEAMVETNHQDVEQWFQAQSEGISLQAMSCSEELQCCQSEILELRC 325
Query: 231 VLSHLQAQRVELQAQTTTLEQAIKSAHECYDDEIQLYNEQIETLRKEIEETERVLEKSSY 290
++ L+ +R L+ ++ A + Y E+ I L +++ E LE+ +
Sbjct: 326 TVNALEVERQAQHTLKDCLQNSLCEAEDRYGTELAQMQSLISNLEEQLSEIRADLERQNQ 385
Query: 291 DCRQLAVAQQTLKNELDRYHRIIEIEGNRLTSAFIETP 328
+ + L + L+NE+ Y ++E E +L TP
Sbjct: 386 EYQVLLDVKARLENEIATYRNLLESEDCKLPCNPCSTP 423
>gi|5031839 keratin 6A [Homo sapiens]
Length = 564
Score = 70.5 bits (171), Expect = 5e-12
Identities = 73/350 (20%), Positives = 143/350 (40%), Gaps = 64/350 (18%)
Query: 44 LQGLGERVAAHVQRARALEQRHAGLRRQLDAFQRLGELA---GPEDALARQVESNRQRVR 100
++ L + A+ + + R LEQ++ L + Q G E + + + R+++
Sbjct: 167 IKTLNNKFASFIDKVRFLEQQNKVLETKWTLLQEQGTKTVRQNLEPLFEQYINNLRRQLD 226
Query: 101 DLEAERARLERQGTEAQRALDEFRSKYENECECQLLLKEMLERLNKEADEALLHNLRLQL 160
+ ER RL+ + Q +++F++KYE+E + + L K+ D A ++ + LQ
Sbjct: 227 SIVGERGRLDSELRGMQDLVEDFKNKYEDEINKRTAAENEFVTLKKDVDAAYMNKVELQA 286
Query: 161 EAQFLQDDISAAKDRHKKNLLEVQTYISILQQIIHTTPPASI------------------ 202
+A L D+I+ + + L ++QT+IS ++ ++
Sbjct: 287 KADTLTDEINFLRALYDAELSQMQTHISDTSVVLSMDNNRNLDLDSIIAEVKAQYEEIAQ 346
Query: 203 ------------------VTSGMREEKLL-TEREVAALRSQLEEGREVLSHLQAQRVELQ 243
VT+G + L T++E+A + ++ R + H++ Q LQ
Sbjct: 347 RSRAEAESWYQTKYEELQVTAGRHGDDLRNTKQEIAEINRMIQRLRSEIDHVKKQCANLQ 406
Query: 244 AQTTTLEQAIKSAHECYDDEIQLYNEQIETLRKEIEETERVLEKSSYDCRQLAVAQQTLK 303
A EQ + A ++ + ++E E L+K+ D +L Q L
Sbjct: 407 AAIADAEQRGEMA--------------LKDAKNKLEGLEDALQKAKQDLARLLKEYQELM 452
Query: 304 N-------ELDRYHRIIEIEGNRLTSAFIETPIPLFTQSHGVSLSTGSGG 346
N E+ Y +++E E RL + QS ++S+G GG
Sbjct: 453 NVKLALDVEIATYRKLLEGEECRLNGEGVGQVNISVVQS---TVSSGYGG 499
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.128 0.345
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,197,414
Number of Sequences: 37866
Number of extensions: 1357971
Number of successful extensions: 11260
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 237
Number of HSP's successfully gapped in prelim test: 940
Number of HSP's that attempted gapping in prelim test: 7653
Number of HSP's gapped (non-prelim): 3442
length of query: 665
length of database: 18,247,518
effective HSP length: 109
effective length of query: 556
effective length of database: 14,120,124
effective search space: 7850788944
effective search space used: 7850788944
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.