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Search of human proteins with 4502193
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4502193 v-raf murine sarcoma 3611 viral oncogene homolog
[Homo sapiens]
(606 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4502193 v-raf murine sarcoma 3611 viral oncogene homolog [Hom... 1237 0.0
gi|4506401 v-raf-1 murine leukemia viral oncogene homolog 1 [Hom... 724 0.0
gi|33188459 B-Raf [Homo sapiens] 679 0.0
gi|75677325 kinase suppressor of ras [Homo sapiens] 181 1e-45
gi|167621456 kinase suppressor of ras 2 [Homo sapiens] 178 1e-44
gi|21735552 mitogen-activated protein kinase kinase kinase 12 [H... 145 1e-34
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens] 145 1e-34
gi|4503787 fyn-related kinase [Homo sapiens] 143 5e-34
gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens] 137 2e-32
gi|4758280 ephrin receptor EphA4 [Homo sapiens] 137 2e-32
gi|4758696 mitogen-activated protein kinase kinase kinase 13 [Ho... 137 2e-32
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap... 136 5e-32
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi... 136 5e-32
gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 133 4e-31
gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 133 4e-31
gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo sapi... 133 4e-31
gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens] 132 9e-31
gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog ... 132 9e-31
gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog is... 132 9e-31
gi|21361241 ephrin receptor EphA3 isoform a precursor [Homo sapi... 131 2e-30
gi|112789548 lymphocyte-specific protein tyrosine kinase precurs... 131 2e-30
gi|112789546 lymphocyte-specific protein tyrosine kinase precurs... 131 2e-30
gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Ho... 130 3e-30
gi|17975768 ephrin receptor EphB3 precursor [Homo sapiens] 130 5e-30
gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens] 129 8e-30
gi|21735550 mitogen-activated protein kinase kinase kinase 10 [H... 128 1e-29
gi|33469982 B lymphoid tyrosine kinase [Homo sapiens] 127 2e-29
gi|10140845 ephrin receptor EphA8 isoform 1 precursor [Homo sapi... 127 2e-29
gi|32528301 EPH receptor B4 precursor [Homo sapiens] 127 4e-29
gi|4758284 ephrin receptor EphB1 precursor [Homo sapiens] 125 9e-29
>gi|4502193 v-raf murine sarcoma 3611 viral oncogene homolog [Homo
sapiens]
Length = 606
Score = 1237 bits (3201), Expect = 0.0
Identities = 606/606 (100%), Positives = 606/606 (100%)
Query: 1 MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV 60
MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
Sbjct: 1 MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV 60
Query: 61 VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF 120
VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
Sbjct: 61 VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF 120
Query: 121 HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRQQFYHSVQDLSGGSRQHEAPSNRPLNELL 180
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRQQFYHSVQDLSGGSRQHEAPSNRPLNELL
Sbjct: 121 HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRQQFYHSVQDLSGGSRQHEAPSNRPLNELL 180
Query: 181 TPQGPSPRTQHCDPEHFPFPAPANAPLQRIRSTSTPNVHMVSTTAPMDSNLIQLTGQSFS 240
TPQGPSPRTQHCDPEHFPFPAPANAPLQRIRSTSTPNVHMVSTTAPMDSNLIQLTGQSFS
Sbjct: 181 TPQGPSPRTQHCDPEHFPFPAPANAPLQRIRSTSTPNVHMVSTTAPMDSNLIQLTGQSFS 240
Query: 241 TDAAGSRGGSDGTPRGSPSPASVSSGRKSPHSKSPAEQRERKSLADDKKKVKNLGYRDSG 300
TDAAGSRGGSDGTPRGSPSPASVSSGRKSPHSKSPAEQRERKSLADDKKKVKNLGYRDSG
Sbjct: 241 TDAAGSRGGSDGTPRGSPSPASVSSGRKSPHSKSPAEQRERKSLADDKKKVKNLGYRDSG 300
Query: 301 YYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRK 360
YYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRK
Sbjct: 301 YYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRK 360
Query: 361 TRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL 420
TRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL
Sbjct: 361 TRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL 420
Query: 421 HAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRM 480
HAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRM
Sbjct: 421 HAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRM 480
Query: 481 QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPK 540
QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPK
Sbjct: 481 QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPK 540
Query: 541 AMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLS 600
AMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLS
Sbjct: 541 AMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLS 600
Query: 601 AARLVP 606
AARLVP
Sbjct: 601 AARLVP 606
>gi|4506401 v-raf-1 murine leukemia viral oncogene homolog 1 [Homo
sapiens]
Length = 648
Score = 724 bits (1869), Expect = 0.0
Identities = 376/607 (61%), Positives = 452/607 (74%), Gaps = 23/607 (3%)
Query: 13 EPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCVVYRLI---KGRK 69
+PS+ T++V+LPNKQRTVV VR+GMS++D L KALKVRGL +CC V+RL+ KG+K
Sbjct: 50 DPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKK 109
Query: 70 TVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLFHGFRCQTCG 129
W+T A L GEEL V+ L+ VPLT HNF RKTF LAFCD C KFL +GFRCQTCG
Sbjct: 110 ARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCG 169
Query: 130 YKFHQHCSSKVPTVCVDMSTNRQQFYHSVQDLSGGSRQHEAPS--NRPLNELLTPQGPSP 187
YKFH+HCS+KVPT+CVD S RQ + G S PS R + E ++ S
Sbjct: 170 YKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTI-GDSGVPALPSLTMRRMRESVSRMPVSS 228
Query: 188 RTQHCDPEHFPF----PAPANAPLQRIRSTSTPNVHMVSTTAPMDSNLIQLTGQSFSTDA 243
+ ++ P F F P+ + QR RSTSTPNVHMVSTT P+DS +I+ DA
Sbjct: 229 QHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIE--------DA 280
Query: 244 AGSRGGSDGTPRGSPSPASVS-SGRKSPHSKSPAEQRERKSLA--DDKKKVKNLGYRDSG 300
S S S SP ++S +G P + PA QRER ++ +K K++ G RDS
Sbjct: 281 IRSHSESASPSALSSSPNNLSPTGWSQPKTPVPA-QRERAPVSGTQEKNKIRPRGQRDSS 339
Query: 301 YYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRK 360
YYWE+ SEV L RIG+GSFGTV++G+WHGDVAVK+LKV PT EQ QAF+NE+ VLRK
Sbjct: 340 YYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRK 399
Query: 361 TRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL 420
TRHVNILLFMG+MT+ AI+TQWCEGSSLY HLHV +T+F M QLID+ARQTAQGMDYL
Sbjct: 400 TRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYL 459
Query: 421 HAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRM 480
HAKNIIHRD+KSNNIFLHEGLTVKIGDFGLATVK+RWSG+Q +EQP+GSVLWMA EVIRM
Sbjct: 460 HAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRM 519
Query: 481 QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPK 540
QD NP+SFQSDVY+YG+VLYELMTG LPYSHI RDQIIFMVGRGY SPDLSK+ NCPK
Sbjct: 520 QDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPK 579
Query: 541 AMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHR-TQADELPACLL 599
AM+RL++DC+K +EERPLFPQIL++IELLQ SLPKI RSASEPSLHR +++ AC L
Sbjct: 580 AMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTL 639
Query: 600 SAARLVP 606
+ + +P
Sbjct: 640 TTSPRLP 646
>gi|33188459 B-Raf [Homo sapiens]
Length = 766
Score = 679 bits (1752), Expect = 0.0
Identities = 359/616 (58%), Positives = 442/616 (71%), Gaps = 41/616 (6%)
Query: 9 ANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCVVYRLIKGR 68
+N P + + V+V+LPNKQRTVV R G++V DSL KAL +RGL +CC VYR+ G
Sbjct: 147 SNPKSPQKPI--VRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGE 204
Query: 69 KTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLFHGFRCQTC 128
K WDT I+ L GEEL VEVLE+VPLT HNFVRKTFF+LAFCDFC K LF GFRCQTC
Sbjct: 205 KKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTC 264
Query: 129 GYKFHQHCSSKVPTVCVDMSTNRQQF------YHSVQD---------LSGGSRQHEAPSN 173
GYKFHQ CS++VP +CV+ F +H + L+ GS S+
Sbjct: 265 GYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASD 324
Query: 174 RPLNELLTPQGPSPRTQHCDPEHFPFPAP--------ANAPLQRIRSTSTPNVHMVSTTA 225
++LT PS + P P P N QR RS+S PNVH ++T
Sbjct: 325 SIGPQILTSPSPS--------KSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVH-INTIE 375
Query: 226 PMDSNLIQLTGQSFSTDAAGSRGGSDGTPRGSPSPASVSSGRKSPHSKSPAEQRERKSLA 285
P++ + + + Q F D GS G TP S P S+++ + S P +R+ S +
Sbjct: 376 PVNIDDL-IRDQGFRGDG-GSTTGLSATPPAS-LPGSLTNVKALQKSPGPQRERKSSSSS 432
Query: 286 DDKKKVKNLGYRDSGYYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTA 345
+D+ ++K LG RDS WE+P ++ + +RIG+GSFGTV++G+WHGDVAVK+L V+ PT
Sbjct: 433 EDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTP 492
Query: 346 EQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQ 405
+Q QAFKNE+ VLRKTRHVNILLFMG+ T+P AI+TQWCEGSSLYHHLH+ +T+F+M++
Sbjct: 493 QQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIK 552
Query: 406 LIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQ 465
LID+ARQTAQGMDYLHAK+IIHRDLKSNNIFLHE LTVKIGDFGLATVK+RWSG+ EQ
Sbjct: 553 LIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQ 612
Query: 466 PSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRG 525
SGS+LWMA EVIRMQD NPYSFQSDVYA+G+VLYELMTG LPYS+I RDQIIFMVGRG
Sbjct: 613 LSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRG 672
Query: 526 YLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPS 585
YLSPDLSK+ SNCPKAM+RL+++CLK +R+ERPLFPQILA+IELL RSLPKI RSASEPS
Sbjct: 673 YLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPS 732
Query: 586 LHR----TQADELPAC 597
L+R T+ L AC
Sbjct: 733 LNRAGFQTEDFSLYAC 748
>gi|75677325 kinase suppressor of ras [Homo sapiens]
Length = 762
Score = 181 bits (460), Expect = 1e-45
Identities = 151/563 (26%), Positives = 245/563 (43%), Gaps = 78/563 (13%)
Query: 90 VLEDVPLTM-HNFVRKTFFSLAFCDFCLKFLFHGFRCQTCGYKFHQHCSSKVPTVCVD-M 147
V D+ L++ H F K++ S C C K + G +C+ C K H C+ + P + +
Sbjct: 201 VRRDIGLSVTHRFSTKSWLSQV-CHVCQKSMIFGVKCKHCRLKCHNKCTKEAPACRISFL 259
Query: 148 STNRQQFYHSV-QDLSGGSRQHEAPSNRPLNELLTPQGPSPRTQHCDPEH---------- 196
R + SV D++ + P L + LT + P H D
Sbjct: 260 PLTRLRRTESVPSDINNPVDRAAEPHFGTLPKALTKKEHPPAMNHLDSSSNPSSTTSSTP 319
Query: 197 ---FPFPAPAN----------APLQRIRSTSTPNVHMVS--------------------T 223
PFP +N +P QR + P + +
Sbjct: 320 SSPAPFPTSSNPSSATTPPNPSPGQRDSRFNFPAAYFIHHRQQFIFPVPSAGHCWKCLLI 379
Query: 224 TAPMDSNLIQLTGQSFSTDAAGSRGGS--DGTPRGSPSPASVSSGRKSPHSKSPAEQRER 281
+ N ++ + + + G+ D P+ A + + KS AE E
Sbjct: 380 AESLKENAFNISAFAHAAPLPEAADGTRLDDQPKADVLEAHEAEAEEPEAGKSEAEDDED 439
Query: 282 KSLADD--------KKKVKNLGYRDSGYY--WEVPPSEVQLLKRIGTGSFGTVFRGRWHG 331
+ DD + + + S Y W++P +V+L + IG G +G V RGRWHG
Sbjct: 440 E--VDDLPSSRRPWRGPISRKASQTSVYLQEWDIPFEQVELGEPIGQGRWGRVHRGRWHG 497
Query: 332 DVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMG-FMTRPGFAIITQWCEGSSL 390
+VA+++L++ + + FK E+ R+TRH N++LFMG M P AIIT +C+G +L
Sbjct: 498 EVAIRLLEMDGHNQDHLKLFKKEVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKGRTL 557
Query: 391 YHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTV--KIGDF 448
+ + T D+ + +A++ +GM YLHAK I+H+DLKS N+F G V G F
Sbjct: 558 HSFVRDPKTSLDINKTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVFYDNGKVVITDFGLF 617
Query: 449 GLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPN------PYSFQSDVYAYGVVLYEL 502
G++ V L+ + ++A E++R P P+S +DVYA+G V YEL
Sbjct: 618 GISGVVREGRRENQLKLSHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVYAFGTVWYEL 677
Query: 503 MTGSLPYSHIGCRDQIIFMVGRGY-LSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFP 561
P + + I+ +G G + L+ +S K + +LS C F +ERP F
Sbjct: 678 QARDWPLKN-QAAEASIWQIGSGEGMKRVLTSVSLG--KEVSEILSACWAFDLQERPSFS 734
Query: 562 QILATIELLQRSLPKIERSASEP 584
++ +E LPK+ R S P
Sbjct: 735 LLMDMLE----KLPKLNRRLSHP 753
>gi|167621456 kinase suppressor of ras 2 [Homo sapiens]
Length = 921
Score = 178 bits (452), Expect = 1e-44
Identities = 106/292 (36%), Positives = 166/292 (56%), Gaps = 19/292 (6%)
Query: 303 WEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTR 362
W++P ++++ + IG G FG V+ GRWHG+VA++++ + + +Q +AFK E+ R+TR
Sbjct: 630 WDIPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTR 689
Query: 363 HVNILLFMG-FMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLH 421
H N++LFMG M+ P AIIT C+G +LY + A D+ + +A++ +GM YLH
Sbjct: 690 HENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLH 749
Query: 422 AKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQ---PLEQPSGSVLWMAAEVI 478
AK I+H+DLKS N+F G V I DFGL ++ + L +G + +A E+I
Sbjct: 750 AKGILHKDLKSKNVFYDNGKVV-ITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEII 808
Query: 479 RMQDPN------PYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLS 532
R P+ P+S SDV+A G + YEL P+ + II+ +G G + P+LS
Sbjct: 809 RQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFK-TQPAEAIIWQMGTG-MKPNLS 866
Query: 533 KISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEP 584
+I K + +L C F++EERP F +++ +E LPK R S P
Sbjct: 867 QIGMG--KEISDILLFCWAFEQEERPTFTKLMDMLE----KLPKRNRRLSHP 912
Score = 35.0 bits (79), Expect = 0.20
Identities = 30/126 (23%), Positives = 54/126 (42%), Gaps = 15/126 (11%)
Query: 99 HNFVRKTFFSLAFCDFCLKFLFHGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRQQFYHSV 158
H F K + S C C K + G +C+ C K H C+ + P C + +R V
Sbjct: 384 HRFSTKYWMSQT-CTVCGKGMLFGLKCKNCKLKCHNKCTKEAPP-CHLLIIHRGDPARLV 441
Query: 159 Q------DLSGGSRQHEAPSNRPLNELLTPQGPSPRTQHCDPEHFPFP-APANAPLQRIR 211
+ D++ R+ S+ +++ L P+T + +H P P P ++
Sbjct: 442 RTESVPCDINNPLRKPPRYSDLHISQTL------PKTNKINKDHIPVPYQPDSSSNPSST 495
Query: 212 STSTPN 217
++STP+
Sbjct: 496 TSSTPS 501
>gi|21735552 mitogen-activated protein kinase kinase kinase 12 [Homo
sapiens]
Length = 859
Score = 145 bits (365), Expect = 1e-34
Identities = 102/273 (37%), Positives = 148/273 (54%), Gaps = 30/273 (10%)
Query: 303 WEVPPSEVQLLKRIGTGSFGTVFRGRWHGD-VAVKVLKVSQPTAEQAQAFKNEMQVLRKT 361
WEVP E+ L+ +G+G+ G VF GR+HG+ VAVK ++ + T +++ LRK
Sbjct: 118 WEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKET---------DIKHLRKL 168
Query: 362 RHVNILLFMGFMTR-PGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL 420
+H NI+ F G T+ P + I+ ++C LY L A L+D + A GM+YL
Sbjct: 169 KHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLR-AGRPVTPSLLVDWSMGIAGGMNYL 227
Query: 421 HAKNIIHRDLKSNNIFLHEGLTVKIGDFG----LATVKTRWSGAQPLEQPSGSVLWMAAE 476
H IIHRDLKS N+ + VKI DFG L+ T+ S A G+V WMA E
Sbjct: 228 HLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFA-------GTVAWMAPE 280
Query: 477 VIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISS 536
VIR + P S + D++++GVVL+EL+TG +PY + II+ VG L + S
Sbjct: 281 VIRNE---PVSEKVDIWSFGVVLWELLTGEIPYKDVD-SSAIIWGVGSNSLH---LPVPS 333
Query: 537 NCPKAMRRLLSDCLKFQREERPLFPQILATIEL 569
+CP + LL C + RP F QIL +++
Sbjct: 334 SCPDGFKILLRQCWNSKPRNRPSFRQILLHLDI 366
>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
Length = 537
Score = 145 bits (365), Expect = 1e-34
Identities = 91/272 (33%), Positives = 145/272 (53%), Gaps = 20/272 (7%)
Query: 303 WEVPPSEVQLLKRIGTGSFGTVFRGRWHGD--VAVKVLKVSQPTAEQAQAFKNEMQVLRK 360
WE+P +QL+KR+G G FG V+ G W+G+ VA+K LK P ++F E Q+++K
Sbjct: 264 WEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLK---PGTMSPESFLEEAQIMKK 320
Query: 361 TRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTR-FDMVQLIDVARQTAQGMDY 419
+H ++ ++ I+T++ SL L + R + L+D+A Q A GM Y
Sbjct: 321 LKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAY 380
Query: 420 LHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATV--KTRWSGAQPLEQPSGSVLWMAAEV 477
+ N IHRDL+S NI + GL KI DFGLA + ++ Q + P + W A E
Sbjct: 381 IERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFP---IKWTAPEA 437
Query: 478 IRMQDPNPYSFQSDVYAYGVVLYELMT-GSLPYSHIGCRDQIIFMVGRGYLSPDLSKISS 536
++ +SDV+++G++L EL+T G +PY + R +++ V RGY P
Sbjct: 438 ALY---GRFTIKSDVWSFGILLTELVTKGRVPYPGMNNR-EVLEQVERGYRMP----CPQ 489
Query: 537 NCPKAMRRLLSDCLKFQREERPLFPQILATIE 568
+CP ++ L+ C K EERP F + + +E
Sbjct: 490 DCPISLHELMIHCWKKDPEERPTFEYLQSFLE 521
>gi|4503787 fyn-related kinase [Homo sapiens]
Length = 505
Score = 143 bits (360), Expect = 5e-34
Identities = 93/276 (33%), Positives = 146/276 (52%), Gaps = 24/276 (8%)
Query: 303 WEVPPSEVQLLKRIGTGSFGTVFRGRWHGD--VAVKVLKVSQPTAEQAQAFKNEMQVLRK 360
WE+ + +QLLKR+G+G FG V+ G W+ VAVK LK P + F E Q+++
Sbjct: 227 WEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLK---PGSMDPNDFLREAQIMKN 283
Query: 361 TRHVNILLFMGFMT-RPGFAIITQWCEGSSLYHHL-HVADTRFDMVQLIDVARQTAQGMD 418
RH ++ T IIT+ SL +L + ++ + Q +D+A Q A GM
Sbjct: 284 LRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMA 343
Query: 419 YLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATV-----KTRWSGAQPLEQPSGSVLWM 473
YL ++N IHRDL + N+ + E K+ DFGLA V + + ++ P V W
Sbjct: 344 YLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLP---VKWT 400
Query: 474 AAEVIRMQDPNPYSFQSDVYAYGVVLYELMT-GSLPYSHIGCRDQIIFMVGRGYLSPDLS 532
A E IR N +S +SDV+++G++LYE++T G +PYS + Q+I M+ + Y P
Sbjct: 401 APEAIR---SNKFSIKSDVWSFGILLYEIITYGKMPYSGM-TGAQVIQMLAQNYRLPQ-- 454
Query: 533 KISSNCPKAMRRLLSDCLKFQREERPLFPQILATIE 568
SNCP+ ++ +C + +ERP F + +E
Sbjct: 455 --PSNCPQQFYNIMLECWNAEPKERPTFETLRWKLE 488
>gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]
Length = 543
Score = 137 bits (346), Expect = 2e-32
Identities = 89/272 (32%), Positives = 144/272 (52%), Gaps = 20/272 (7%)
Query: 303 WEVPPSEVQLLKRIGTGSFGTVFRGRWHGD--VAVKVLKVSQPTAEQAQAFKNEMQVLRK 360
WE+P ++L ++G G FG V+ G W+G VA+K LK P +AF E Q+++K
Sbjct: 270 WEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLK---PGTMMPEAFLQEAQIMKK 326
Query: 361 TRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRF-DMVQLIDVARQTAQGMDY 419
RH ++ ++ I+T++ SL L D ++ + QL+D+A Q A GM Y
Sbjct: 327 LRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAY 386
Query: 420 LHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATV--KTRWSGAQPLEQPSGSVLWMAAEV 477
+ N IHRDL++ NI + E L KI DFGLA + ++ Q + P + W A E
Sbjct: 387 IERMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFP---IKWTAPEA 443
Query: 478 IRMQDPNPYSFQSDVYAYGVVLYELMT-GSLPYSHIGCRDQIIFMVGRGYLSPDLSKISS 536
++ +SDV+++G++ EL+T G +PY + R +++ V RGY P
Sbjct: 444 ALY---GRFTIKSDVWSFGILQTELVTKGRVPYPGMVNR-EVLEQVERGYRMP----CPQ 495
Query: 537 NCPKAMRRLLSDCLKFQREERPLFPQILATIE 568
CP+++ L++ C K +ERP F I + +E
Sbjct: 496 GCPESLHELMNLCWKKDPDERPTFEYIQSFLE 527
>gi|4758280 ephrin receptor EphA4 [Homo sapiens]
Length = 986
Score = 137 bits (346), Expect = 2e-32
Identities = 107/344 (31%), Positives = 171/344 (49%), Gaps = 24/344 (6%)
Query: 261 ASVSSGRKSPHSKSPAEQRERKSLADDKKK-VKNLGYRDSG-----YYWEVPPSEVQLLK 314
A V S R+S +SK+ E E K L + V Y D + E+ S +++ K
Sbjct: 566 AFVISRRRSKYSKAKQEADEEKHLNQGVRTYVDPFTYEDPNQAVREFAKEIDASCIKIEK 625
Query: 315 RIGTGSFGTVFRGRWHGD------VAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILL 368
IG G FG V GR VA+K LK T +Q + F +E ++ + H NI+
Sbjct: 626 VIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGY-TDKQRRDFLSEASIMGQFDHPNIIH 684
Query: 369 FMGFMTR-PGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIH 427
G +T+ IIT++ E SL L D RF ++QL+ + R GM YL + +H
Sbjct: 685 LEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSDMSYVH 744
Query: 428 RDLKSNNIFLHEGLTVKIGDFGLATV-KTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPY 486
RDL + NI ++ L K+ DFG++ V + A + W A E I + +
Sbjct: 745 RDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYR---KF 801
Query: 487 SFQSDVYAYGVVLYELMT-GSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRL 545
+ SDV++YG+V++E+M+ G PY + +D +I + GY P +CP A+ +L
Sbjct: 802 TSASDVWSYGIVMWEVMSYGERPYWDMSNQD-VIKAIEEGYRLPP----PMDCPIALHQL 856
Query: 546 LSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRT 589
+ DC + +R +RP F QI+ ++ L R+ ++R+ +E S T
Sbjct: 857 MLDCWQKERSDRPKFGQIVNMLDKLIRNPNSLKRTGTESSRPNT 900
>gi|4758696 mitogen-activated protein kinase kinase kinase 13 [Homo
sapiens]
Length = 966
Score = 137 bits (346), Expect = 2e-32
Identities = 96/273 (35%), Positives = 144/273 (52%), Gaps = 30/273 (10%)
Query: 303 WEVPPSEVQLLKRIGTGSFGTVFRGRWHGD-VAVKVLKVSQPTAEQAQAFKNEMQVLRKT 361
WEVP E+ L+ +G+G+ G VF G++ + VA+K ++ T +++ LRK
Sbjct: 161 WEVPFEEISELQWLGSGAQGAVFLGKFRAEEVAIKKVREQNET---------DIKHLRKL 211
Query: 362 RHVNILLFMGFMTR-PGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL 420
+H NI+ F G T+ P + II ++C LY L A + L+D + A GM+YL
Sbjct: 212 KHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLR-AGRKITPRLLVDWSTGIASGMNYL 270
Query: 421 HAKNIIHRDLKSNNIFLHEGLTVKIGDFG----LATVKTRWSGAQPLEQPSGSVLWMAAE 476
H IIHRDLKS N+ + VKI DFG L+ T+ S A G+V WMA E
Sbjct: 271 HLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFA-------GTVAWMAPE 323
Query: 477 VIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISS 536
VIR + P S + D++++GVVL+EL+TG +PY + II+ VG L + S
Sbjct: 324 VIRNE---PVSEKVDIWSFGVVLWELLTGEIPYKDVD-SSAIIWGVGSNSLH---LPVPS 376
Query: 537 NCPKAMRRLLSDCLKFQREERPLFPQILATIEL 569
CP + L+ + + RP F Q L +++
Sbjct: 377 TCPDGFKILMKQTWQSKPRNRPSFRQTLMHLDI 409
>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 136 bits (343), Expect = 5e-32
Identities = 88/272 (32%), Positives = 143/272 (52%), Gaps = 20/272 (7%)
Query: 303 WEVPPSEVQLLKRIGTGSFGTVFRGRWHGD--VAVKVLKVSQPTAEQAQAFKNEMQVLRK 360
WE+P ++L ++G G FG V+ G W+G VA+K LK P +AF E QV++K
Sbjct: 263 WEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLK---PGTMSPEAFLQEAQVMKK 319
Query: 361 TRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRF-DMVQLIDVARQTAQGMDY 419
RH ++ ++ I+T++ SL L ++ + QL+D+A Q A GM Y
Sbjct: 320 LRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAY 379
Query: 420 LHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATV--KTRWSGAQPLEQPSGSVLWMAAEV 477
+ N +HRDL++ NI + E L K+ DFGLA + ++ Q + P + W A E
Sbjct: 380 VERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFP---IKWTAPEA 436
Query: 478 IRMQDPNPYSFQSDVYAYGVVLYELMT-GSLPYSHIGCRDQIIFMVGRGYLSPDLSKISS 536
++ +SDV+++G++L EL T G +PY + R +++ V RGY P
Sbjct: 437 ALY---GRFTIKSDVWSFGILLTELTTKGRVPYPGMVNR-EVLDQVERGYRMP----CPP 488
Query: 537 NCPKAMRRLLSDCLKFQREERPLFPQILATIE 568
CP+++ L+ C + + EERP F + A +E
Sbjct: 489 ECPESLHDLMCQCWRKEPEERPTFEYLQAFLE 520
>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 136 bits (343), Expect = 5e-32
Identities = 88/272 (32%), Positives = 143/272 (52%), Gaps = 20/272 (7%)
Query: 303 WEVPPSEVQLLKRIGTGSFGTVFRGRWHGD--VAVKVLKVSQPTAEQAQAFKNEMQVLRK 360
WE+P ++L ++G G FG V+ G W+G VA+K LK P +AF E QV++K
Sbjct: 263 WEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLK---PGTMSPEAFLQEAQVMKK 319
Query: 361 TRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRF-DMVQLIDVARQTAQGMDY 419
RH ++ ++ I+T++ SL L ++ + QL+D+A Q A GM Y
Sbjct: 320 LRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAY 379
Query: 420 LHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATV--KTRWSGAQPLEQPSGSVLWMAAEV 477
+ N +HRDL++ NI + E L K+ DFGLA + ++ Q + P + W A E
Sbjct: 380 VERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFP---IKWTAPEA 436
Query: 478 IRMQDPNPYSFQSDVYAYGVVLYELMT-GSLPYSHIGCRDQIIFMVGRGYLSPDLSKISS 536
++ +SDV+++G++L EL T G +PY + R +++ V RGY P
Sbjct: 437 ALY---GRFTIKSDVWSFGILLTELTTKGRVPYPGMVNR-EVLDQVERGYRMP----CPP 488
Query: 537 NCPKAMRRLLSDCLKFQREERPLFPQILATIE 568
CP+++ L+ C + + EERP F + A +E
Sbjct: 489 ECPESLHDLMCQCWRKEPEERPTFEYLQAFLE 520
>gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 133 bits (335), Expect = 4e-31
Identities = 88/270 (32%), Positives = 139/270 (51%), Gaps = 16/270 (5%)
Query: 303 WEVPPSEVQLLKRIGTGSFGTVFRGRWHGD--VAVKVLKVSQPTAEQAQAFKNEMQVLRK 360
WE+ S + L +R+GTG FG V+ G W+G VAVK LK P +AF E QV++
Sbjct: 256 WEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLK---PGTMSPKAFLEEAQVMKL 312
Query: 361 TRHVNILLFMGFMTRPGFAIITQW-CEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDY 419
RH ++ ++ I+T++ C GS L + + QL+D+A Q A+GM Y
Sbjct: 313 LRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAY 372
Query: 420 LHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIR 479
+ N IHRDL++ NI + E L KI DFGLA + + P + + W A E
Sbjct: 373 MERMNYIHRDLRAANILVGERLACKIADFGLARL-IKDDEYNPCQGSKFPIKWTAPEAAL 431
Query: 480 MQDPNPYSFQSDVYAYGVVLYELMT-GSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNC 538
++ +SDV+++G++L EL+T G +PY + R +++ V +GY P C
Sbjct: 432 F---GRFTIKSDVWSFGILLTELITKGRIPYPGMNKR-EVLEQVEQGYHMP----CPPGC 483
Query: 539 PKAMRRLLSDCLKFQREERPLFPQILATIE 568
P ++ + + EERP F + + +E
Sbjct: 484 PASLYEAMEQTWRLDPEERPTFEYLQSFLE 513
>gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 133 bits (335), Expect = 4e-31
Identities = 88/270 (32%), Positives = 139/270 (51%), Gaps = 16/270 (5%)
Query: 303 WEVPPSEVQLLKRIGTGSFGTVFRGRWHGD--VAVKVLKVSQPTAEQAQAFKNEMQVLRK 360
WE+ S + L +R+GTG FG V+ G W+G VAVK LK P +AF E QV++
Sbjct: 256 WEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLK---PGTMSPKAFLEEAQVMKL 312
Query: 361 TRHVNILLFMGFMTRPGFAIITQW-CEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDY 419
RH ++ ++ I+T++ C GS L + + QL+D+A Q A+GM Y
Sbjct: 313 LRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAY 372
Query: 420 LHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIR 479
+ N IHRDL++ NI + E L KI DFGLA + + P + + W A E
Sbjct: 373 MERMNYIHRDLRAANILVGERLACKIADFGLARL-IKDDEYNPCQGSKFPIKWTAPEAAL 431
Query: 480 MQDPNPYSFQSDVYAYGVVLYELMT-GSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNC 538
++ +SDV+++G++L EL+T G +PY + R +++ V +GY P C
Sbjct: 432 F---GRFTIKSDVWSFGILLTELITKGRIPYPGMNKR-EVLEQVEQGYHMP----CPPGC 483
Query: 539 PKAMRRLLSDCLKFQREERPLFPQILATIE 568
P ++ + + EERP F + + +E
Sbjct: 484 PASLYEAMEQTWRLDPEERPTFEYLQSFLE 513
>gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 133 bits (335), Expect = 4e-31
Identities = 88/270 (32%), Positives = 139/270 (51%), Gaps = 16/270 (5%)
Query: 303 WEVPPSEVQLLKRIGTGSFGTVFRGRWHGD--VAVKVLKVSQPTAEQAQAFKNEMQVLRK 360
WE+ S + L +R+GTG FG V+ G W+G VAVK LK P +AF E QV++
Sbjct: 256 WEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLK---PGTMSPKAFLEEAQVMKL 312
Query: 361 TRHVNILLFMGFMTRPGFAIITQW-CEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDY 419
RH ++ ++ I+T++ C GS L + + QL+D+A Q A+GM Y
Sbjct: 313 LRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAY 372
Query: 420 LHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIR 479
+ N IHRDL++ NI + E L KI DFGLA + + P + + W A E
Sbjct: 373 MERMNYIHRDLRAANILVGERLACKIADFGLARL-IKDDEYNPCQGSKFPIKWTAPEAAL 431
Query: 480 MQDPNPYSFQSDVYAYGVVLYELMT-GSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNC 538
++ +SDV+++G++L EL+T G +PY + R +++ V +GY P C
Sbjct: 432 F---GRFTIKSDVWSFGILLTELITKGRIPYPGMNKR-EVLEQVEQGYHMP----CPPGC 483
Query: 539 PKAMRRLLSDCLKFQREERPLFPQILATIE 568
P ++ + + EERP F + + +E
Sbjct: 484 PASLYEAMEQTWRLDPEERPTFEYLQSFLE 513
>gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]
Length = 534
Score = 132 bits (332), Expect = 9e-31
Identities = 88/272 (32%), Positives = 141/272 (51%), Gaps = 20/272 (7%)
Query: 303 WEVPPSEVQLLKRIGTGSFGTVFRGRWHGD--VAVKVLKVSQPTAEQAQAFKNEMQVLRK 360
WEV + L K++G G F V+ G W+G+ VA+K LK P ++F E Q+++K
Sbjct: 261 WEVARRSLCLEKKLGQGCFAEVWLGTWNGNTKVAIKTLK---PGTMSPESFLEEAQIMKK 317
Query: 361 TRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTR-FDMVQLIDVARQTAQGMDY 419
+H ++ ++ I+T++ SL L + R + L+D+A Q A GM Y
Sbjct: 318 LKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAY 377
Query: 420 LHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATV--KTRWSGAQPLEQPSGSVLWMAAEV 477
+ N IHRDL+S NI + GL KI DFGLA + ++ Q + P + W A E
Sbjct: 378 IERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFP---IKWTAPEA 434
Query: 478 IRMQDPNPYSFQSDVYAYGVVLYELMT-GSLPYSHIGCRDQIIFMVGRGYLSPDLSKISS 536
++ +SDV+++G++L EL+T G +PY + R +++ V RGY P
Sbjct: 435 ALY---GRFTIKSDVWSFGILLTELVTKGRVPYPGMNNR-EVLEQVERGYRMP----CPQ 486
Query: 537 NCPKAMRRLLSDCLKFQREERPLFPQILATIE 568
+CP ++ L+ C K EERP F + + +E
Sbjct: 487 DCPISLHELMIHCWKKDPEERPTFEYLQSFLE 518
>gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform B [Homo sapiens]
Length = 491
Score = 132 bits (332), Expect = 9e-31
Identities = 88/273 (32%), Positives = 145/273 (53%), Gaps = 21/273 (7%)
Query: 303 WEVPPSEVQLLKRIGTGSFGTVFRGRWHGD--VAVKVLKVSQPTAEQAQAFKNEMQVLRK 360
WE+P ++L+KR+G G FG V+ G ++ VAVK LK P QAF E +++
Sbjct: 219 WEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLK---PGTMSVQAFLEEANLMKT 275
Query: 361 TRHVNILLFMGFMTRPG-FAIITQWCEGSSLYHHLHVADT-RFDMVQLIDVARQTAQGMD 418
+H ++ +TR IIT++ SL L + + + +LID + Q A+GM
Sbjct: 276 LQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMA 335
Query: 419 YLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATV--KTRWSGAQPLEQPSGSVLWMAAE 476
Y+ KN IHRDL++ N+ + E L KI DFGLA V ++ + + P + W A E
Sbjct: 336 YIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFP---IKWTAPE 392
Query: 477 VIRMQDPNPYSFQSDVYAYGVVLYELMT-GSLPYSHIGCRDQIIFMVGRGYLSPDLSKIS 535
I ++ +SDV+++G++LYE++T G +PY D ++ + +GY P +
Sbjct: 393 AINF---GCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNAD-VMTALSQGYRMPRV---- 444
Query: 536 SNCPKAMRRLLSDCLKFQREERPLFPQILATIE 568
NCP + ++ C K + EERP F + + ++
Sbjct: 445 ENCPDELYDIMKMCWKEKAEERPTFDYLQSVLD 477
>gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform A [Homo sapiens]
Length = 512
Score = 132 bits (332), Expect = 9e-31
Identities = 88/273 (32%), Positives = 145/273 (53%), Gaps = 21/273 (7%)
Query: 303 WEVPPSEVQLLKRIGTGSFGTVFRGRWHGD--VAVKVLKVSQPTAEQAQAFKNEMQVLRK 360
WE+P ++L+KR+G G FG V+ G ++ VAVK LK P QAF E +++
Sbjct: 240 WEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLK---PGTMSVQAFLEEANLMKT 296
Query: 361 TRHVNILLFMGFMTRPG-FAIITQWCEGSSLYHHLHVADT-RFDMVQLIDVARQTAQGMD 418
+H ++ +TR IIT++ SL L + + + +LID + Q A+GM
Sbjct: 297 LQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMA 356
Query: 419 YLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATV--KTRWSGAQPLEQPSGSVLWMAAE 476
Y+ KN IHRDL++ N+ + E L KI DFGLA V ++ + + P + W A E
Sbjct: 357 YIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFP---IKWTAPE 413
Query: 477 VIRMQDPNPYSFQSDVYAYGVVLYELMT-GSLPYSHIGCRDQIIFMVGRGYLSPDLSKIS 535
I ++ +SDV+++G++LYE++T G +PY D ++ + +GY P +
Sbjct: 414 AINF---GCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNAD-VMTALSQGYRMPRV---- 465
Query: 536 SNCPKAMRRLLSDCLKFQREERPLFPQILATIE 568
NCP + ++ C K + EERP F + + ++
Sbjct: 466 ENCPDELYDIMKMCWKEKAEERPTFDYLQSVLD 498
>gi|21361241 ephrin receptor EphA3 isoform a precursor [Homo
sapiens]
Length = 983
Score = 131 bits (330), Expect = 2e-30
Identities = 95/294 (32%), Positives = 149/294 (50%), Gaps = 21/294 (7%)
Query: 304 EVPPSEVQLLKRIGTGSFGTVFRGRW------HGDVAVKVLKVSQPTAEQAQAFKNEMQV 357
E+ + + + K +G G FG V GR VA+K LKV T +Q + F E +
Sbjct: 615 ELDATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGY-TEKQRRDFLGEASI 673
Query: 358 LRKTRHVNILLFMGFMTRPG-FAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQG 416
+ + H NI+ G +T+ I+T++ E SL L D +F ++QL+ + R A G
Sbjct: 674 MGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASG 733
Query: 417 MDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATV-KTRWSGAQPLEQPSGSVLWMAA 475
M YL +HRDL + NI ++ L K+ DFGL+ V + A + W +
Sbjct: 734 MKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSP 793
Query: 476 EVIRMQDPNPYSFQSDVYAYGVVLYELMT-GSLPYSHIGCRDQIIFMVGRGYLSPDLSKI 534
E I + ++ SDV++YG+VL+E+M+ G PY + +D +I V GY P
Sbjct: 794 EAIAYR---KFTSASDVWSYGIVLWEVMSYGERPYWEMSNQD-VIKAVDEGYRLPP---- 845
Query: 535 SSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQR---SLPKIERSASEPS 585
+CP A+ +L+ DC + R RP F QI++ ++ L R SL I +A+ PS
Sbjct: 846 PMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILDKLIRNPGSLKIITSAAARPS 899
>gi|112789548 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 131 bits (329), Expect = 2e-30
Identities = 83/272 (30%), Positives = 150/272 (55%), Gaps = 20/272 (7%)
Query: 303 WEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTR 362
WEVP ++L++R+G G FG V+ G ++G V V + Q + AF E ++++ +
Sbjct: 238 WEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSP-DAFLAEANLMKQLQ 296
Query: 363 HVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHV-ADTRFDMVQLIDVARQTAQGMDYLH 421
H ++ +T+ IIT++ E SL L + + + +L+D+A Q A+GM ++
Sbjct: 297 HQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIE 356
Query: 422 AKNIIHRDLKSNNIFLHEGLTVKIGDFGLATV--KTRWSGAQPLEQPSGSVLWMAAEVIR 479
+N IHRDL++ NI + + L+ KI DFGLA + ++ + + P + W A E I
Sbjct: 357 ERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFP---IKWTAPEAIN 413
Query: 480 MQDPNPYSFQSDVYAYGVVLYELMT-GSLPYSHIGCRDQIIFMVGRGY--LSPDLSKISS 536
++ +SDV+++G++L E++T G +PY + ++I + RGY + PD
Sbjct: 414 Y---GTFTIKSDVWSFGILLTEIVTHGRIPYPGM-TNPEVIQNLERGYRMVRPD------ 463
Query: 537 NCPKAMRRLLSDCLKFQREERPLFPQILATIE 568
NCP+ + +L+ C K + E+RP F + + +E
Sbjct: 464 NCPEELYQLMRLCWKERPEDRPTFDYLRSVLE 495
>gi|112789546 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 131 bits (329), Expect = 2e-30
Identities = 83/272 (30%), Positives = 150/272 (55%), Gaps = 20/272 (7%)
Query: 303 WEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTR 362
WEVP ++L++R+G G FG V+ G ++G V V + Q + AF E ++++ +
Sbjct: 238 WEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSP-DAFLAEANLMKQLQ 296
Query: 363 HVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHV-ADTRFDMVQLIDVARQTAQGMDYLH 421
H ++ +T+ IIT++ E SL L + + + +L+D+A Q A+GM ++
Sbjct: 297 HQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIE 356
Query: 422 AKNIIHRDLKSNNIFLHEGLTVKIGDFGLATV--KTRWSGAQPLEQPSGSVLWMAAEVIR 479
+N IHRDL++ NI + + L+ KI DFGLA + ++ + + P + W A E I
Sbjct: 357 ERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFP---IKWTAPEAIN 413
Query: 480 MQDPNPYSFQSDVYAYGVVLYELMT-GSLPYSHIGCRDQIIFMVGRGY--LSPDLSKISS 536
++ +SDV+++G++L E++T G +PY + ++I + RGY + PD
Sbjct: 414 Y---GTFTIKSDVWSFGILLTEIVTHGRIPYPGM-TNPEVIQNLERGYRMVRPD------ 463
Query: 537 NCPKAMRRLLSDCLKFQREERPLFPQILATIE 568
NCP+ + +L+ C K + E+RP F + + +E
Sbjct: 464 NCPEELYQLMRLCWKERPEDRPTFDYLRSVLE 495
>gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Homo
sapiens]
Length = 847
Score = 130 bits (327), Expect = 3e-30
Identities = 119/393 (30%), Positives = 176/393 (44%), Gaps = 62/393 (15%)
Query: 243 AAGSRGGSDGTPRGSPSPASVSSGRKSP-HSKSPAEQRERKSLADDKKKVKNLGYRDSGY 301
+ G GG G P GSP A ++ + P+ Q E D+ +V + SG
Sbjct: 21 SGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGD 80
Query: 302 --YWE--------------------VPPSEV------QLLKRIGTGSFGTVFRGRWHGD- 332
+W PP EV +L + IG G FG V+RG W G+
Sbjct: 81 EGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGEL 140
Query: 333 VAVKVLKVS--QPTAEQAQAFKNEMQVLRKTRHVNILLFMGF-MTRPGFAIITQWCEGSS 389
VAVK + + + A++ + E ++ H NI+ + P ++ ++ G
Sbjct: 141 VAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGP 200
Query: 390 LYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKN---IIHRDLKSNNIFLHEGL----- 441
L L A R L++ A Q A+GM YLH + +IHRDLKSNNI L + +
Sbjct: 201 LSRAL--AGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDM 258
Query: 442 ---TVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVV 498
T+KI DFGLA W + +G+ WMA EVI+ + +S SDV+++GV+
Sbjct: 259 EHKTLKITDFGLAR---EWHKTTQMSA-AGTYAWMAPEVIKA---STFSKGSDVWSFGVL 311
Query: 499 LYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLS-KISSNCPKAMRRLLSDCLKFQREER 557
L+EL+TG +PY I C V G L+ I S CP+ +L++DC R
Sbjct: 312 LWELLTGEVPYRGIDC-----LAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRR 366
Query: 558 PLFPQILATIELLQRSLPKIERSASEPSLHRTQ 590
P F IL +E L+ ++ R S H Q
Sbjct: 367 PDFASILQQLEALE---AQVLREMPRDSFHSMQ 396
>gi|17975768 ephrin receptor EphB3 precursor [Homo sapiens]
Length = 998
Score = 130 bits (326), Expect = 5e-30
Identities = 100/310 (32%), Positives = 156/310 (50%), Gaps = 34/310 (10%)
Query: 304 EVPPSEVQLLKRIGTGSFGTVFRGRWHGD------VAVKVLKVSQPTAEQAQAFKNEMQV 357
E+ S V++ + IG G FG V RGR VA+K LKV T Q + F +E +
Sbjct: 627 EIDVSCVKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGY-TERQRRDFLSEASI 685
Query: 358 LRKTRHVNILLFMGFMTRPG-FAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQG 416
+ + H NI+ G +T+ I+T++ E +L L + D +F ++QL+ + R A G
Sbjct: 686 MGQFDHPNIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAG 745
Query: 417 MDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVL----- 471
M YL N +HRDL + NI ++ L K+ DFGL +R+ P + S L
Sbjct: 746 MKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGL----SRFLEDDPSDPTYTSSLGGKIP 801
Query: 472 --WMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMT-GSLPYSHIGCRDQIIFMVGRGYLS 528
W A E I + ++ SDV++YG+V++E+M+ G PY + +D +I V + Y
Sbjct: 802 IRWTAPEAIAYR---KFTSASDVWSYGIVMWEVMSYGERPYWDMSNQD-VINAVEQDYRL 857
Query: 529 PDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRS------LPKIERSAS 582
P +CP A+ +L+ DC R RP F QI+ T++ L R+ + + S
Sbjct: 858 PP----PMDCPTALHQLMLDCWVRDRNLRPKFSQIVNTLDKLIRNAASLKVIASAQSGMS 913
Query: 583 EPSLHRTQAD 592
+P L RT D
Sbjct: 914 QPLLDRTVPD 923
>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
Length = 526
Score = 129 bits (324), Expect = 8e-30
Identities = 84/272 (30%), Positives = 144/272 (52%), Gaps = 20/272 (7%)
Query: 303 WEVPPSEVQLLKRIGTGSFGTVFRGRW--HGDVAVKVLKVSQPTAEQAQAFKNEMQVLRK 360
WE+P ++L K++G G FG V+ + H VAVK +K P + +AF E V++
Sbjct: 255 WEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMK---PGSMSVEAFLAEANVMKT 311
Query: 361 TRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVAD-TRFDMVQLIDVARQTAQGMDY 419
+H ++ +T+ IIT++ SL L + ++ + +LID + Q A+GM +
Sbjct: 312 LQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAF 371
Query: 420 LHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATV--KTRWSGAQPLEQPSGSVLWMAAEV 477
+ +N IHRDL++ NI + L KI DFGLA V ++ + + P + W A E
Sbjct: 372 IEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFP---IKWTAPEA 428
Query: 478 IRMQDPNPYSFQSDVYAYGVVLYELMT-GSLPYSHIGCRDQIIFMVGRGYLSPDLSKISS 536
I ++ +SDV+++G++L E++T G +PY + ++I + RGY P
Sbjct: 429 INF---GSFTIKSDVWSFGILLMEIVTYGRIPYPGMS-NPEVIRALERGYRMPR----PE 480
Query: 537 NCPKAMRRLLSDCLKFQREERPLFPQILATIE 568
NCP+ + ++ C K + EERP F I + ++
Sbjct: 481 NCPEELYNIMMRCWKNRPEERPTFEYIQSVLD 512
>gi|21735550 mitogen-activated protein kinase kinase kinase 10 [Homo
sapiens]
Length = 954
Score = 128 bits (322), Expect = 1e-29
Identities = 99/286 (34%), Positives = 146/286 (51%), Gaps = 30/286 (10%)
Query: 304 EVPPSEVQLLKRIGTGSFGTVFRGRWHGD-VAVKVLKVS--QPTAEQAQAFKNEMQVLRK 360
E+P E+QL + IG G FG V+R W G+ VAVK ++ + A A+ E ++
Sbjct: 92 EIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGA 151
Query: 361 TRHVNILLFMGF-MTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDY 419
+H NI+ G + P ++ ++ G +L L A R L++ A Q A+GM+Y
Sbjct: 152 LQHPNIIALRGACLNPPHLCLVMEYARGGALSRVL--AGRRVPPHVLVNWAVQVARGMNY 209
Query: 420 LHAKN---IIHRDLKSNNIFLHEGL--------TVKIGDFGLATVKTRWSGAQPLEQPSG 468
LH IIHRDLKS NI + E + +KI DFGLA W + +G
Sbjct: 210 LHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAR---EWHKTTKMSA-AG 265
Query: 469 SVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLS 528
+ WMA EVIR+ + +S SDV+++GV+L+EL+TG +PY I V G
Sbjct: 266 TYAWMAPEVIRL---SLFSKSSDVWSFGVLLWELLTGEVPYREIDA-----LAVAYGVAM 317
Query: 529 PDLS-KISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRS 573
L+ I S CP+ RLL +C RP F IL +E++++S
Sbjct: 318 NKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLEVIEQS 363
>gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]
Length = 505
Score = 127 bits (320), Expect = 2e-29
Identities = 83/270 (30%), Positives = 146/270 (54%), Gaps = 16/270 (5%)
Query: 303 WEVPPSEVQLLKRIGTGSFGTVFRGRWHGD--VAVKVLKVSQPTAEQAQAFKNEMQVLRK 360
WE+P ++L++++G+G FG V+ G + + VA+K LK + E AF E V++
Sbjct: 234 WEIPRQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPE---AFLGEANVMKA 290
Query: 361 TRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVAD-TRFDMVQLIDVARQTAQGMDY 419
+H ++ +T+ I+T++ L L + +R + +LID++ Q A+GM Y
Sbjct: 291 LQHERLVRLYAVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAY 350
Query: 420 LHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIR 479
+ N IHRDL++ NI + E L KI DFGLA + AQ E + W A E I
Sbjct: 351 IERMNSIHRDLRAANILVSEALCCKIADFGLARIIDSEYTAQ--EGAKFPIKWTAPEAIH 408
Query: 480 MQDPNPYSFQSDVYAYGVVLYELMT-GSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNC 538
++ ++DV+++GV+L E++T G +PY + ++I + RGY P + +
Sbjct: 409 F---GVFTIKADVWSFGVLLMEVVTYGRVPYPGMS-NPEVIRNLERGYRMP---RPDTCP 461
Query: 539 PKAMRRLLSDCLKFQREERPLFPQILATIE 568
P+ R ++++C + + EERP F + + +E
Sbjct: 462 PELYRGVIAECWRSRPEERPTFEFLQSVLE 491
>gi|10140845 ephrin receptor EphA8 isoform 1 precursor [Homo
sapiens]
Length = 1005
Score = 127 bits (320), Expect = 2e-29
Identities = 92/288 (31%), Positives = 143/288 (49%), Gaps = 18/288 (6%)
Query: 304 EVPPSEVQLLKRIGTGSFGTVFRGRWHGD------VAVKVLKVSQPTAEQAQAFKNEMQV 357
E+ S + + K IG+G G V GR VA+K LK T Q + F +E +
Sbjct: 629 EIEASRIHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGY-TERQRRDFLSEASI 687
Query: 358 LRKTRHVNILLFMGFMTRPGFA-IITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQG 416
+ + H NI+ G +TR A I+T++ E SL L D +F ++QL+ + R G
Sbjct: 688 MGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDTFLRTHDGQFTIMQLVGMLRGVGAG 747
Query: 417 MDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATV-KTRWSGAQPLEQPSGSVLWMAA 475
M YL +HRDL + N+ + L K+ DFGL+ V + A + W A
Sbjct: 748 MRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAP 807
Query: 476 EVIRMQDPNPYSFQSDVYAYGVVLYELMT-GSLPYSHIGCRDQIIFMVGRGYLSPDLSKI 534
E I + +S SDV+++GVV++E++ G PY ++ RD +I V GY P
Sbjct: 808 EAIAFR---TFSSASDVWSFGVVMWEVLAYGERPYWNMTNRD-VISSVEEGYRLP----A 859
Query: 535 SSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSAS 582
CP A+ +L+ DC R +RP F QI++ ++ L RS + +A+
Sbjct: 860 PMGCPHALHQLMLDCWHKDRAQRPRFSQIVSVLDALIRSPESLRATAT 907
>gi|32528301 EPH receptor B4 precursor [Homo sapiens]
Length = 987
Score = 127 bits (318), Expect = 4e-29
Identities = 93/304 (30%), Positives = 152/304 (50%), Gaps = 26/304 (8%)
Query: 304 EVPPSEVQLLKRIGTGSFGTVFRGRWHGD------VAVKVLKVSQPTAEQAQAFKNEMQV 357
E+ S V++ + IG G FG V RGR VA+K LK T Q + F +E +
Sbjct: 609 EIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGY-TERQRREFLSEASI 667
Query: 358 LRKTRHVNILLFMGFMTRP-GFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQG 416
+ + H NI+ G +T I+T++ E +L L + D +F ++QL+ + R A G
Sbjct: 668 MGQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASG 727
Query: 417 MDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGS---VLWM 473
M YL + +HRDL + NI ++ L K+ DFGL+ S G + W
Sbjct: 728 MRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTYTSSLGGKIPIRWT 787
Query: 474 AAEVIRMQDPNPYSFQSDVYAYGVVLYELMT-GSLPYSHIGCRDQIIFMVGRGYLSPDLS 532
A E I + ++ SD ++YG+V++E+M+ G PY + +D +I + + Y P
Sbjct: 788 APEAIAFR---KFTSASDAWSYGIVMWEVMSFGERPYWDMSNQD-VINAIEQDYRLPP-- 841
Query: 533 KISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQR---SLPKIER---SASEPSL 586
+CP ++ +L+ DC + R RP FPQ+++ ++ + R SL + R AS P L
Sbjct: 842 --PPDCPTSLHQLMLDCWQKDRNARPRFPQVVSALDKMIRNPASLKIVARENGGASHPLL 899
Query: 587 HRTQ 590
+ Q
Sbjct: 900 DQRQ 903
>gi|4758284 ephrin receptor EphB1 precursor [Homo sapiens]
Length = 984
Score = 125 bits (315), Expect = 9e-29
Identities = 93/306 (30%), Positives = 155/306 (50%), Gaps = 26/306 (8%)
Query: 304 EVPPSEVQLLKRIGTGSFGTVFRGRWHGD------VAVKVLKVSQPTAEQAQAFKNEMQV 357
E+ S V++ + IG G FG V++GR VA+K LK + +Q + F +E +
Sbjct: 613 EIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGY-SEKQRRDFLSEASI 671
Query: 358 LRKTRHVNILLFMGFMTRPG-FAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQG 416
+ + H NI+ G +T+ IIT++ E +L L D +F ++QL+ + R A G
Sbjct: 672 MGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAG 731
Query: 417 MDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGS---VLWM 473
M YL N +HRDL + NI ++ L K+ DFGL+ + G V W
Sbjct: 732 MKYLAEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWT 791
Query: 474 AAEVIRMQDPNPYSFQSDVYAYGVVLYELMT-GSLPYSHIGCRDQIIFMVGRGYLSPDLS 532
A E I + ++ SDV++YG+V++E+M+ G PY + +D +I + + Y P
Sbjct: 792 APEAIAYR---KFTSASDVWSYGIVMWEVMSFGERPYWDMSNQD-VINAIEQDYRLPP-- 845
Query: 533 KISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSA------SEPSL 586
+CP A+ +L+ DC + R RP F +I+ T++ + R+ ++ A S+P L
Sbjct: 846 --PMDCPAALHQLMLDCWQKDRNSRPRFAEIVNTLDKMIRNPASLKTVATITAVPSQPLL 903
Query: 587 HRTQAD 592
R+ D
Sbjct: 904 DRSIPD 909
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.134 0.411
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,021,023
Number of Sequences: 37866
Number of extensions: 1230375
Number of successful extensions: 7986
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 696
Number of HSP's successfully gapped in prelim test: 238
Number of HSP's that attempted gapping in prelim test: 5585
Number of HSP's gapped (non-prelim): 1352
length of query: 606
length of database: 18,247,518
effective HSP length: 108
effective length of query: 498
effective length of database: 14,157,990
effective search space: 7050679020
effective search space used: 7050679020
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.