Search of human proteins with 4501893

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4501893 actinin, alpha 2 [Homo sapiens]
         (894 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4501893 actinin, alpha 2 [Homo sapiens]                           1795   0.0  
gi|4557241 actinin, alpha 3 [Homo sapiens]                           1481   0.0  
gi|194097352 actinin, alpha 1 isoform c [Homo sapiens]               1470   0.0  
gi|194097350 actinin, alpha 1 isoform a [Homo sapiens]               1456   0.0  
gi|4501891 actinin, alpha 1 isoform b [Homo sapiens]                 1455   0.0  
gi|12025678 actinin, alpha 4 [Homo sapiens]                          1422   0.0  
gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo ...   432   e-121
gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo ...   431   e-120
gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens]          431   e-120
gi|67782321 spectrin beta isoform a [Homo sapiens]                    416   e-116
gi|67782319 spectrin beta isoform b [Homo sapiens]                    416   e-116
gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1 [...   398   e-110
gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens]        346   6e-95
gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ...   280   3e-75
gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ...   280   3e-75
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                        241   3e-63
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                        240   4e-63
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                       239   6e-63
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                       239   6e-63
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                        239   6e-63
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                        239   6e-63
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                        239   6e-63
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                        239   6e-63
gi|34577047 dystonin isoform 1 [Homo sapiens]                         237   3e-62
gi|169218211 PREDICTED: similar to plectin 1, partial [Homo sapi...   237   4e-62
gi|221316624 dystonin isoform 4 [Homo sapiens]                        234   2e-61
gi|221316622 dystonin isoform 3 [Homo sapiens]                        234   2e-61
gi|221316618 dystonin isoform 2 [Homo sapiens]                        234   2e-61
gi|33188445 microfilament and actin filament cross-linker protei...   229   9e-60
gi|115298659 spectrin, alpha, erythrocytic 1 [Homo sapiens]           206   6e-53

>gi|4501893 actinin, alpha 2 [Homo sapiens]
          Length = 894

 Score = 1795 bits (4650), Expect = 0.0
 Identities = 894/894 (100%), Positives = 894/894 (100%)

Query: 1   MNQIEPGVQYNYVYDEDEYMIQEEEWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIE 60
           MNQIEPGVQYNYVYDEDEYMIQEEEWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIE
Sbjct: 1   MNQIEPGVQYNYVYDEDEYMIQEEEWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIE 60

Query: 61  NIEEDFRNGLKLMLLLEVISGERLPKPDRGKMRFHKIANVNKALDYIASKGVKLVSIGAE 120
           NIEEDFRNGLKLMLLLEVISGERLPKPDRGKMRFHKIANVNKALDYIASKGVKLVSIGAE
Sbjct: 61  NIEEDFRNGLKLMLLLEVISGERLPKPDRGKMRFHKIANVNKALDYIASKGVKLVSIGAE 120

Query: 121 EIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNIQNFHTSW 180
           EIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNIQNFHTSW
Sbjct: 121 EIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNIQNFHTSW 180

Query: 181 KDGLGLCALIHRHRPDLIDYSKLNKDDPIGNINLAMEIAEKHLDIPKMLDAEDIVNTPKP 240
           KDGLGLCALIHRHRPDLIDYSKLNKDDPIGNINLAMEIAEKHLDIPKMLDAEDIVNTPKP
Sbjct: 181 KDGLGLCALIHRHRPDLIDYSKLNKDDPIGNINLAMEIAEKHLDIPKMLDAEDIVNTPKP 240

Query: 241 DERAIMTYVSCFYHAFAGAEQAETAANRICKVLAVNQENERLMEEYERLASELLEWIRRT 300
           DERAIMTYVSCFYHAFAGAEQAETAANRICKVLAVNQENERLMEEYERLASELLEWIRRT
Sbjct: 241 DERAIMTYVSCFYHAFAGAEQAETAANRICKVLAVNQENERLMEEYERLASELLEWIRRT 300

Query: 301 IPWLENRTPEKTMQAMQKKLEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAF 360
           IPWLENRTPEKTMQAMQKKLEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAF
Sbjct: 301 IPWLENRTPEKTMQAMQKKLEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAF 360

Query: 361 MPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGK 420
           MPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGK
Sbjct: 361 MPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGK 420

Query: 421 EQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVN 480
           EQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVN
Sbjct: 421 EQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVN 480

Query: 481 DRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQ 540
           DRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQ
Sbjct: 481 DRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQ 540

Query: 541 DMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYS 600
           DMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYS
Sbjct: 541 DMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYS 600

Query: 601 TVTMDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEI 660
           TVTMDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEI
Sbjct: 601 TVTMDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEI 660

Query: 661 ARSSIQITGALEDQMNQLKQYEHNIINYKNNIDKLEGDHQLIQEALVFDNKHTNYTMEHI 720
           ARSSIQITGALEDQMNQLKQYEHNIINYKNNIDKLEGDHQLIQEALVFDNKHTNYTMEHI
Sbjct: 661 ARSSIQITGALEDQMNQLKQYEHNIINYKNNIDKLEGDHQLIQEALVFDNKHTNYTMEHI 720

Query: 721 RVGWELLLTTIARTINEVETQILTRDAKGITQEQMNEFRASFNHFDRRKNGLMDHEDFRA 780
           RVGWELLLTTIARTINEVETQILTRDAKGITQEQMNEFRASFNHFDRRKNGLMDHEDFRA
Sbjct: 721 RVGWELLLTTIARTINEVETQILTRDAKGITQEQMNEFRASFNHFDRRKNGLMDHEDFRA 780

Query: 781 CLISMGYDLGEAEFARIMTLVDPNGQGTVTFQSFIDFMTRETADTDTAEQVIASFRILAS 840
           CLISMGYDLGEAEFARIMTLVDPNGQGTVTFQSFIDFMTRETADTDTAEQVIASFRILAS
Sbjct: 781 CLISMGYDLGEAEFARIMTLVDPNGQGTVTFQSFIDFMTRETADTDTAEQVIASFRILAS 840

Query: 841 DKPYILAEELRRELPPDQAQYCIKRMPAYSGPGSVPGALDYAAFSSALYGESDL 894
           DKPYILAEELRRELPPDQAQYCIKRMPAYSGPGSVPGALDYAAFSSALYGESDL
Sbjct: 841 DKPYILAEELRRELPPDQAQYCIKRMPAYSGPGSVPGALDYAAFSSALYGESDL 894


>gi|4557241 actinin, alpha 3 [Homo sapiens]
          Length = 901

 Score = 1481 bits (3833), Expect = 0.0
 Identities = 713/877 (81%), Positives = 801/877 (91%)

Query: 18  EYMIQEEEWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLE 77
           EYM QEE+WDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLE
Sbjct: 25  EYMEQEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLE 84

Query: 78  VISGERLPKPDRGKMRFHKIANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTLGMIWTI 137
           VISGERLP+PD+GKMRFHKIANVNKALD+IASKGVKLVSIGAEEIVDGN+KMTLGMIWTI
Sbjct: 85  VISGERLPRPDKGKMRFHKIANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTI 144

Query: 138 ILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPDL 197
           ILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVN+QNFHTSWKDGL LCALIHRHRPDL
Sbjct: 145 ILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPDL 204

Query: 198 IDYSKLNKDDPIGNINLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFA 257
           IDY+KL KDDPIGN+N A E+AEK+LDIPKMLDAEDIVNTPKPDE+AIMTYVSCFYHAFA
Sbjct: 205 IDYAKLRKDDPIGNLNTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFA 264

Query: 258 GAEQAETAANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQ 317
           GAEQAETAANRICKVLAVNQENE+LMEEYE+LASELLEWIRRT+PWLENR  E +M AMQ
Sbjct: 265 GAEQAETAANRICKVLAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQ 324

Query: 318 KKLEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQR 377
           +KLEDFRDYRR HKPP++QEKCQLEINFNTLQTKLR+S+RPAFMPSEGK+VSDIA AW+ 
Sbjct: 325 RKLEDFRDYRRLHKPPRIQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRG 384

Query: 378 LEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEV 437
           LEQ EKGYE+WLL+EIRRL+RL+HLAEKFRQKAS HE W  GKE++L Q+DY+SA L EV
Sbjct: 385 LEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEV 444

Query: 438 RALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLT 497
           RALLR+HEAFESDLAAHQDRVE IAA+AQELNELDYH+A +VN RCQ ICDQWD LGTLT
Sbjct: 445 RALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLT 504

Query: 498 QKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITA 557
           QKRR+ALERMEKLLETIDQL LEFA+RAAPFNNW++GA+EDLQD+++VHS+EE QSL+TA
Sbjct: 505 QKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTA 564

Query: 558 HEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQL 617
           H+QFKATLPEAD ER +IM IQ E++K+ Q+Y +R  S+NPY T++  ++ TKWD V++L
Sbjct: 565 HDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKL 624

Query: 618 VPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITGALEDQMNQ 677
           VP RDQ+LQEELARQ  NERLRRQFAAQANAIGPWIQ K+EE+ R +  + G+LE+QM  
Sbjct: 625 VPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQAKVEEVGRLAAGLAGSLEEQMAG 684

Query: 678 LKQYEHNIINYKNNIDKLEGDHQLIQEALVFDNKHTNYTMEHIRVGWELLLTTIARTINE 737
           L+Q E NIINYK NID+LEGDHQL+QE+LVFDNKHT Y+MEHIRVGWE LLT+IARTINE
Sbjct: 685 LRQQEQNIINYKTNIDRLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLLTSIARTINE 744

Query: 738 VETQILTRDAKGITQEQMNEFRASFNHFDRRKNGLMDHEDFRACLISMGYDLGEAEFARI 797
           VE Q+LTRDAKG++QEQ+NEFRASFNHFDR++NG+M+ +DFRACLISMGYDLGE EFARI
Sbjct: 745 VENQVLTRDAKGLSQEQLNEFRASFNHFDRKRNGMMEPDDFRACLISMGYDLGEVEFARI 804

Query: 798 MTLVDPNGQGTVTFQSFIDFMTRETADTDTAEQVIASFRILASDKPYILAEELRRELPPD 857
           MT+VDPN  G VTFQ+FIDFMTRETA+TDT EQV+ASF+ILA DK YI  EELRRELP  
Sbjct: 805 MTMVDPNAAGVVTFQAFIDFMTRETAETDTTEQVVASFKILAGDKNYITPEELRRELPAK 864

Query: 858 QAQYCIKRMPAYSGPGSVPGALDYAAFSSALYGESDL 894
           QA+YCI+RM  Y G G+  GALDY AFSSALYGESDL
Sbjct: 865 QAEYCIRRMVPYKGSGAPAGALDYVAFSSALYGESDL 901


>gi|194097352 actinin, alpha 1 isoform c [Homo sapiens]
          Length = 887

 Score = 1470 bits (3806), Expect = 0.0
 Identities = 713/878 (81%), Positives = 797/878 (90%)

Query: 17  DEYMIQEEEWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLL 76
           ++YM  EE+WDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFR+GLKLMLLL
Sbjct: 10  NDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLL 69

Query: 77  EVISGERLPKPDRGKMRFHKIANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTLGMIWT 136
           EVISGERL KP+RGKMR HKI+NVNKALD+IASKGVKLVSIGAEEIVDGNVKMTLGMIWT
Sbjct: 70  EVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWT 129

Query: 137 IILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPD 196
           IILRFAIQDISVEETSAKEGLLLWCQRKTAPY+NVNIQNFH SWKDGLG CALIHRHRP+
Sbjct: 130 IILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPE 189

Query: 197 LIDYSKLNKDDPIGNINLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAF 256
           LIDY KL KDDP+ N+N A ++AEK+LDIPKMLDAEDIV T +PDE+AIMTYVS FYHAF
Sbjct: 190 LIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAF 249

Query: 257 AGAEQAETAANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAM 316
           +GA++AETAANRICKVLAVNQENE+LME+YE+LAS+LLEWIRRTIPWLENR PE TM AM
Sbjct: 250 SGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAM 309

Query: 317 QKKLEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQ 376
           Q+KLEDFRDYRR HKPPKVQEKCQLEINFNTLQTKLR+SNRPAFMPSEG+MVSDI  AW 
Sbjct: 310 QQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWG 369

Query: 377 RLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTE 436
            LEQ EKGYEEWLLNEIRRLERL+HLAEKFRQKAS HE W  GKE +L QKDYE+A+L+E
Sbjct: 370 CLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSE 429

Query: 437 VRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTL 496
           ++ALL+KHEAFESDLAAHQDRVEQIAAIAQELNELDY+D+ +VN RCQKICDQWD LG L
Sbjct: 430 IKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGAL 489

Query: 497 TQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLIT 556
           TQKRREALER EKLLETIDQL+LE+AKRAAPFNNWMEGAMEDLQD FIVH+IEEIQ L T
Sbjct: 490 TQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTT 549

Query: 557 AHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQ 616
           AHEQFKATLP+AD ER +I+ I NEV K++Q+Y++ ++ +NPY+T+T  E+  KWD V+Q
Sbjct: 550 AHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQ 609

Query: 617 LVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITGALEDQMN 676
           LVP RDQ+L EE ARQ  NERLR+QF AQAN IGPWIQ KMEEI R SI++ G LEDQ++
Sbjct: 610 LVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLS 669

Query: 677 QLKQYEHNIINYKNNIDKLEGDHQLIQEALVFDNKHTNYTMEHIRVGWELLLTTIARTIN 736
            L+QYE +I+NYK  ID+LEGDHQLIQEAL+FDNKHTNYTMEHIRVGWE LLTTIARTIN
Sbjct: 670 HLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTIN 729

Query: 737 EVETQILTRDAKGITQEQMNEFRASFNHFDRRKNGLMDHEDFRACLISMGYDLGEAEFAR 796
           EVE QILTRDAKGI+QEQMNEFRASFNHFDR+K G+MD +DFRACLISMGY++GEAEFAR
Sbjct: 730 EVENQILTRDAKGISQEQMNEFRASFNHFDRKKTGMMDTDDFRACLISMGYNMGEAEFAR 789

Query: 797 IMTLVDPNGQGTVTFQSFIDFMTRETADTDTAEQVIASFRILASDKPYILAEELRRELPP 856
           IM++VDPN  G VTFQ+FIDFM+RETADTDTA+QV+ASF+ILA DK YI  +ELRRELPP
Sbjct: 790 IMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELRRELPP 849

Query: 857 DQAQYCIKRMPAYSGPGSVPGALDYAAFSSALYGESDL 894
           DQA+YCI RM  Y+GP SVPGALDY +FS+ALYGESDL
Sbjct: 850 DQAEYCIARMAPYTGPDSVPGALDYMSFSTALYGESDL 887


>gi|194097350 actinin, alpha 1 isoform a [Homo sapiens]
          Length = 914

 Score = 1456 bits (3768), Expect = 0.0
 Identities = 713/905 (78%), Positives = 797/905 (88%), Gaps = 27/905 (2%)

Query: 17  DEYMIQEEEWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLL 76
           ++YM  EE+WDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFR+GLKLMLLL
Sbjct: 10  NDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLL 69

Query: 77  EVISGERLPKPDRGKMRFHKIANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTLGMIWT 136
           EVISGERL KP+RGKMR HKI+NVNKALD+IASKGVKLVSIGAEEIVDGNVKMTLGMIWT
Sbjct: 70  EVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWT 129

Query: 137 IILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPD 196
           IILRFAIQDISVEETSAKEGLLLWCQRKTAPY+NVNIQNFH SWKDGLG CALIHRHRP+
Sbjct: 130 IILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPE 189

Query: 197 LIDYSKLNKDDPIGNINLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAF 256
           LIDY KL KDDP+ N+N A ++AEK+LDIPKMLDAEDIV T +PDE+AIMTYVS FYHAF
Sbjct: 190 LIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAF 249

Query: 257 AGAEQAETAANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAM 316
           +GA++AETAANRICKVLAVNQENE+LME+YE+LAS+LLEWIRRTIPWLENR PE TM AM
Sbjct: 250 SGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAM 309

Query: 317 QKKLEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQ 376
           Q+KLEDFRDYRR HKPPKVQEKCQLEINFNTLQTKLR+SNRPAFMPSEG+MVSDI  AW 
Sbjct: 310 QQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWG 369

Query: 377 RLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTE 436
            LEQ EKGYEEWLLNEIRRLERL+HLAEKFRQKAS HE W  GKE +L QKDYE+A+L+E
Sbjct: 370 CLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSE 429

Query: 437 VRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTL 496
           ++ALL+KHEAFESDLAAHQDRVEQIAAIAQELNELDY+D+ +VN RCQKICDQWD LG L
Sbjct: 430 IKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGAL 489

Query: 497 TQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLIT 556
           TQKRREALER EKLLETIDQL+LE+AKRAAPFNNWMEGAMEDLQD FIVH+IEEIQ L T
Sbjct: 490 TQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTT 549

Query: 557 AHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQ 616
           AHEQFKATLP+AD ER +I+ I NEV K++Q+Y++ ++ +NPY+T+T  E+  KWD V+Q
Sbjct: 550 AHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQ 609

Query: 617 LVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITGALEDQMN 676
           LVP RDQ+L EE ARQ  NERLR+QF AQAN IGPWIQ KMEEI R SI++ G LEDQ++
Sbjct: 610 LVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLS 669

Query: 677 QLKQYEHNIINYKNNIDKLEGDHQLIQEALVFDNKHTNYTMEHIRVGWELLLTTIARTIN 736
            L+QYE +I+NYK  ID+LEGDHQLIQEAL+FDNKHTNYTMEHIRVGWE LLTTIARTIN
Sbjct: 670 HLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTIN 729

Query: 737 EVETQILTRDAKGITQEQMNEFRASFNHFDR---------------------------RK 769
           EVE QILTRDAKGI+QEQMNEFRASFNHFDR                           +K
Sbjct: 730 EVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQKK 789

Query: 770 NGLMDHEDFRACLISMGYDLGEAEFARIMTLVDPNGQGTVTFQSFIDFMTRETADTDTAE 829
            G+MD +DFRACLISMGY++GEAEFARIM++VDPN  G VTFQ+FIDFM+RETADTDTA+
Sbjct: 790 TGMMDTDDFRACLISMGYNMGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTAD 849

Query: 830 QVIASFRILASDKPYILAEELRRELPPDQAQYCIKRMPAYSGPGSVPGALDYAAFSSALY 889
           QV+ASF+ILA DK YI  +ELRRELPPDQA+YCI RM  Y+GP SVPGALDY +FS+ALY
Sbjct: 850 QVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTALY 909

Query: 890 GESDL 894
           GESDL
Sbjct: 910 GESDL 914


>gi|4501891 actinin, alpha 1 isoform b [Homo sapiens]
          Length = 892

 Score = 1455 bits (3766), Expect = 0.0
 Identities = 709/883 (80%), Positives = 794/883 (89%), Gaps = 5/883 (0%)

Query: 17  DEYMIQEEEWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLL 76
           ++YM  EE+WDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFR+GLKLMLLL
Sbjct: 10  NDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLL 69

Query: 77  EVISGERLPKPDRGKMRFHKIANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTLGMIWT 136
           EVISGERL KP+RGKMR HKI+NVNKALD+IASKGVKLVSIGAEEIVDGNVKMTLGMIWT
Sbjct: 70  EVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWT 129

Query: 137 IILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPD 196
           IILRFAIQDISVEETSAKEGLLLWCQRKTAPY+NVNIQNFH SWKDGLG CALIHRHRP+
Sbjct: 130 IILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPE 189

Query: 197 LIDYSKLNKDDPIGNINLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAF 256
           LIDY KL KDDP+ N+N A ++AEK+LDIPKMLDAEDIV T +PDE+AIMTYVS FYHAF
Sbjct: 190 LIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAF 249

Query: 257 AGAEQAETAANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAM 316
           +GA++AETAANRICKVLAVNQENE+LME+YE+LAS+LLEWIRRTIPWLENR PE TM AM
Sbjct: 250 SGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAM 309

Query: 317 QKKLEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQ 376
           Q+KLEDFRDYRR HKPPKVQEKCQLEINFNTLQTKLR+SNRPAFMPSEG+MVSDI  AW 
Sbjct: 310 QQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWG 369

Query: 377 RLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTE 436
            LEQ EKGYEEWLLNEIRRLERL+HLAEKFRQKAS HE W  GKE +L QKDYE+A+L+E
Sbjct: 370 CLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSE 429

Query: 437 VRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTL 496
           ++ALL+KHEAFESDLAAHQDRVEQIAAIAQELNELDY+D+ +VN RCQKICDQWD LG L
Sbjct: 430 IKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGAL 489

Query: 497 TQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLIT 556
           TQKRREALER EKLLETIDQL+LE+AKRAAPFNNWMEGAMEDLQD FIVH+IEEIQ L T
Sbjct: 490 TQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTT 549

Query: 557 AHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQ 616
           AHEQFKATLP+AD ER +I+ I NEV K++Q+Y++ ++ +NPY+T+T  E+  KWD V+Q
Sbjct: 550 AHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQ 609

Query: 617 LVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITGALEDQMN 676
           LVP RDQ+L EE ARQ  NERLR+QF AQAN IGPWIQ KMEEI R SI++ G LEDQ++
Sbjct: 610 LVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLS 669

Query: 677 QLKQYEHNIINYKNNIDKLEGDHQLIQEALVFDNKHTNYTMEHIRVGWELLLTTIARTIN 736
            L+QYE +I+NYK  ID+LEGDHQLIQEAL+FDNKHTNYTMEHIRVGWE LLTTIARTIN
Sbjct: 670 HLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTIN 729

Query: 737 EVETQILTRDAKGITQEQMNEFRASFNHFDRRKNGLMDHEDFRACLISMGYDL-----GE 791
           EVE QILTRDAKGI+QEQMNEFRASFNHFDR  +G +  E+F+ACLIS+GYD+     GE
Sbjct: 730 EVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQGE 789

Query: 792 AEFARIMTLVDPNGQGTVTFQSFIDFMTRETADTDTAEQVIASFRILASDKPYILAEELR 851
           AEFARIM++VDPN  G VTFQ+FIDFM+RETADTDTA+QV+ASF+ILA DK YI  +ELR
Sbjct: 790 AEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELR 849

Query: 852 RELPPDQAQYCIKRMPAYSGPGSVPGALDYAAFSSALYGESDL 894
           RELPPDQA+YCI RM  Y+GP SVPGALDY +FS+ALYGESDL
Sbjct: 850 RELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTALYGESDL 892


>gi|12025678 actinin, alpha 4 [Homo sapiens]
          Length = 911

 Score = 1422 bits (3680), Expect = 0.0
 Identities = 688/882 (78%), Positives = 785/882 (89%), Gaps = 5/882 (0%)

Query: 18  EYMIQEEEWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLE 77
           +YM QE++WDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENI+EDFR+GLKLMLLLE
Sbjct: 30  DYMAQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLE 89

Query: 78  VISGERLPKPDRGKMRFHKIANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTLGMIWTI 137
           VISGERLPKP+RGKMR HKI NVNKALD+IASKGVKLVSIGAEEIVDGN KMTLGMIWTI
Sbjct: 90  VISGERLPKPERGKMRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTI 149

Query: 138 ILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPDL 197
           ILRFAIQDISVEETSAKEGLLLWCQRKTAPY+NVN+QNFH SWKDGL   ALIHRHRP+L
Sbjct: 150 ILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPEL 209

Query: 198 IDYSKLNKDDPIGNINLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFA 257
           I+Y KL KDDP+ N+N A E+AEK+LDIPKMLDAEDIVNT +PDE+AIMTYVS FYHAF+
Sbjct: 210 IEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFS 269

Query: 258 GAEQAETAANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQ 317
           GA++AETAANRICKVLAVNQENE LME+YE+LAS+LLEWIRRTIPWLE+R P+KT+Q MQ
Sbjct: 270 GAQKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQ 329

Query: 318 KKLEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQR 377
           +KLEDFRDYRR HKPPKVQEKCQLEINFNTLQTKLR+SNRPAFMPSEGKMVSDI   WQ 
Sbjct: 330 QKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQH 389

Query: 378 LEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEV 437
           LEQAEKGYEEWLLNEIRRLERL+HLAEKFRQKAS HE W  GKE +L  +DYE+A+L+++
Sbjct: 390 LEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDI 449

Query: 438 RALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLT 497
           +AL+RKHEAFESDLAAHQDRVEQIAAIAQELNELDY+D+ NVN RCQKICDQWD LG+LT
Sbjct: 450 KALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLT 509

Query: 498 QKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITA 557
             RREALE+ EK LE IDQLHLE+AKRAAPFNNWME AMEDLQDMFIVH+IEEI+ LI+A
Sbjct: 510 HSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISA 569

Query: 558 HEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQL 617
           H+QFK+TLP+AD ER++I+AI  E +++ +S +I++S SNPY+TVT   + +KW+KV+QL
Sbjct: 570 HDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQL 629

Query: 618 VPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITGALEDQMNQ 677
           VP RD +L EE ++Q +NE LRRQFA+QAN +GPWIQ KMEEI R SI++ G LEDQ++ 
Sbjct: 630 VPKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTKMEEIGRISIEMNGTLEDQLSH 689

Query: 678 LKQYEHNIINYKNNIDKLEGDHQLIQEALVFDNKHTNYTMEHIRVGWELLLTTIARTINE 737
           LKQYE +I++YK N+D LE  HQLIQEAL+FDNKHTNYTMEHIRVGWE LLTTIARTINE
Sbjct: 690 LKQYERSIVDYKPNLDLLEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINE 749

Query: 738 VETQILTRDAKGITQEQMNEFRASFNHFDRRKNGLMDHEDFRACLISMGYDL-----GEA 792
           VE QILTRDAKGI+QEQM EFRASFNHFD+   G +  E+F+ACLIS+GYD+     GEA
Sbjct: 750 VENQILTRDAKGISQEQMQEFRASFNHFDKDHGGALGPEEFKACLISLGYDVENDRQGEA 809

Query: 793 EFARIMTLVDPNGQGTVTFQSFIDFMTRETADTDTAEQVIASFRILASDKPYILAEELRR 852
           EF RIM+LVDPN  G VTFQ+FIDFM+RET DTDTA+QVIASF++LA DK +I AEELRR
Sbjct: 810 EFNRIMSLVDPNHSGLVTFQAFIDFMSRETTDTDTADQVIASFKVLAGDKNFITAEELRR 869

Query: 853 ELPPDQAQYCIKRMPAYSGPGSVPGALDYAAFSSALYGESDL 894
           ELPPDQA+YCI RM  Y GP +VPGALDY +FS+ALYGESDL
Sbjct: 870 ELPPDQAEYCIARMAPYQGPDAVPGALDYKSFSTALYGESDL 911


>gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo
           sapiens]
          Length = 2155

 Score =  432 bits (1110), Expect = e-121
 Identities = 233/505 (46%), Positives = 324/505 (64%), Gaps = 20/505 (3%)

Query: 8   VQYNYVYDEDEY-MIQEEEWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDF 66
           V YNY   E  +  +Q+E            E  Q+KTFT W NSHL +   +I ++  D 
Sbjct: 21  VPYNYNQLEGRFKQLQDER-----------EAVQKKTFTKWVNSHLARVSCRITDLYTDL 69

Query: 67  RNGLKLMLLLEVISGERLPKPDRGKMRFHKIANVNKALDYIASKGVKLVSIGAEEIVDGN 126
           R+G  L+ LLEV+SGERLPKP +G+MR H + NV+KAL ++  + V L ++G+ +IVDGN
Sbjct: 70  RDGRMLIKLLEVLSGERLPKPTKGRMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGN 129

Query: 127 VKMTLGMIWTIILRFAIQDISVE------ETSAKEGLLLWCQRKTAPYRNVNIQNFHTSW 180
            ++TLG+IWTIILRF IQDISVE      + SAK+ LLLWCQ KTA Y NVNI NF TSW
Sbjct: 130 HRLTLGLIWTIILRFQIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSW 189

Query: 181 KDGLGLCALIHRHRPDLIDYSKLNKDDPIGNINLAMEIAEKHLDIPKMLDAEDIVNTPKP 240
           +DG+   ALIH+HRPDLID+ KL K +   N+  A  +AE+HL + K+LD EDI +   P
Sbjct: 190 RDGMAFNALIHKHRPDLIDFDKLKKSNAHYNLQNAFNLAEQHLGLTKLLDPEDI-SVDHP 248

Query: 241 DERAIMTYVSCFYHAFAGAEQAETAANRICKVLAVNQENERLMEEYERLASELLEWIRRT 300
           DE++I+TYV  +YH F+  +       RI KVL    E E+++E+YE LAS+LLEWI +T
Sbjct: 249 DEKSIITYVVTYYHYFSKMKALAVEGKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQT 308

Query: 301 IPWLENRTPEKTMQAMQKKLEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAF 360
           I  L NR    ++  +Q++L+ F  YR   KPPK  EK  LE+   T+Q+K+R +N+  +
Sbjct: 309 IIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVY 368

Query: 361 MPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGK 420
           MP EGK++SDI  AW+RLE+AE   E  L NE+ R E+LE LA +F +KA+  ETW   +
Sbjct: 369 MPREGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETW-LSE 427

Query: 421 EQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVN 480
            Q L+ +D     L  V A  +KHEA E+D+AA+++RV+ + A+A+EL   +YHD   + 
Sbjct: 428 NQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRIT 487

Query: 481 DRCQKICDQWDRLGTLTQKRREALE 505
            R   +   W+ L  L + RR+ LE
Sbjct: 488 ARKDNVIRLWEYLLELLRARRQRLE 512



 Score = 76.6 bits (187), Expect = 9e-14
 Identities = 78/316 (24%), Positives = 135/316 (42%), Gaps = 35/316 (11%)

Query: 360 FMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAE--KFRQKASTHETWA 417
           + P + +++ D      R+   E  Y+E       R  RLE      KF  + +  E W 
Sbjct: 588 YKPCDPQVIRD------RVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWI 641

Query: 418 YGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAV 477
             KE+IL   DY    LT V  LL KH AFE +++      EQ     +++   ++  + 
Sbjct: 642 REKEKILSSDDY-GKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSE 700

Query: 478 NVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAME 537
            + +R   I +QW  L  L+  R+       K LE    LH +F   A   + WM   ++
Sbjct: 701 KIRERIIYIREQWANLEQLSAIRK-------KRLEEASLLH-QFQADADDIDAWMLDILK 752

Query: 538 DLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSN 597
            +    + H     QSL+  H   K    E    R ++  +  +   + Q +     + +
Sbjct: 753 IVSSSDVGHDEYSTQSLVKKH---KDVAEEIANYRPTLDTLHEQASALPQEH-----AES 804

Query: 598 PYSTVTMDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKM 657
           P     +  +  ++ +V +L  +R Q+LQ+ LA       L + F ++A+A   WI  K 
Sbjct: 805 PDVRGRLSGIEERYKEVAELTRLRKQALQDTLA-------LYKMF-SEADACELWIDEKE 856

Query: 658 EEIARSSIQITGALED 673
           + +  +++QI   LED
Sbjct: 857 QWL--NNMQIPEKLED 870



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 104/552 (18%), Positives = 209/552 (37%), Gaps = 82/552 (14%)

Query: 172  NIQNFHTSWKDGLGLCALIHRHRPD-------LIDYSKLNKDDPIGNINLAME-IAEKHL 223
            N++      K  L   +L+H+ + D       ++D  K+     +G+   + + + +KH 
Sbjct: 715  NLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHK 774

Query: 224  DIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQAETAANRICKVLAVNQENERLM 283
            D+     AE+I N  +P    +    S      A +       + I       +E  + +
Sbjct: 775  DV-----AEEIANY-RPTLDTLHEQASALPQEHAESPDVRGRLSGI-------EERYKEV 821

Query: 284  EEYERLASELLE-----------------WIRRTIPWLENRTPEKTMQAMQKKLEDFR-- 324
             E  RL  + L+                 WI     WL N         + +KLED    
Sbjct: 822  AELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNN-------MQIPEKLEDLEVI 874

Query: 325  DYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSD-IAGAWQRLEQAEK 383
             +R +   P++  +       N +  +L  S  P+    E K   D +   W +  +   
Sbjct: 875  QHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPS--EKEIKAQQDKLNTRWSQFRELVD 932

Query: 384  GYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRK 443
              ++ LL+ +          + +  + +  ++W   K +++         L  V AL RK
Sbjct: 933  RKKDALLSALS--------IQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRK 984

Query: 444  HEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREA 503
                E DL A + ++  +   A++L       A  +  R  +I D W+ + T  + R  +
Sbjct: 985  LTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREAS 1044

Query: 504  LERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKA 563
            L    KL +        F +    F +W+      +    + +++ E + L+T HE  K 
Sbjct: 1045 LGEASKLQQ--------FLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIK- 1095

Query: 564  TLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQ 623
               E D   +    +++  E V Q    +  +   +    +  L T W+++ ++     +
Sbjct: 1096 --NEIDNYEEDYQKMRDMGEMVTQG---QTDAQYMFLRQRLQALDTGWNELHKMW----E 1146

Query: 624  SLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITGALEDQMNQLKQYEH 683
            + Q  L++ HA ++  R    QA A   ++ N+   +A + +  T  LE     +K+ E 
Sbjct: 1147 NRQNLLSQSHAYQQFLRD-TKQAEA---FLNNQEYVLAHTEMPTT--LEGAEAAIKKQED 1200

Query: 684  NIINYKNNIDKL 695
             +     N +K+
Sbjct: 1201 FMTTMDANEEKI 1212



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 89/435 (20%), Positives = 169/435 (38%), Gaps = 60/435 (13%)

Query: 278  ENERLMEEYERLASELLEW---IRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHKPPK 334
            E   L+ +++  A ++  W   I + +   +    E + Q++ KK +D  +    ++P  
Sbjct: 728  EEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRP-- 785

Query: 335  VQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIR 394
                        TL T   +  + + +P E     D+ G    +E+  K   E  L  +R
Sbjct: 786  ------------TLDT---LHEQASALPQEHAESPDVRGRLSGIEERYKEVAE--LTRLR 828

Query: 395  RLERLEHLA-EKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAA 453
            +    + LA  K   +A   E W   KEQ L         L ++  +  + E+ E ++  
Sbjct: 829  KQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPE-KLEDLEVIQHRFESLEPEMNN 887

Query: 454  HQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLET 513
               RV  +  IA++L    +     +  +  K+  +W +   L  ++++AL  +  L  +
Sbjct: 888  QASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDAL--LSAL--S 943

Query: 514  IDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQ 573
            I   HLE  +      +W+    +          IE  Q L        A   +  G  +
Sbjct: 944  IQNYHLECNET----KSWIREKTK---------VIESTQDLGNDLAGVMALQRKLTGMER 990

Query: 574  SIMAIQNEVEKVIQSYNIRISSSNPYSTVT----MDELRTKWDKVKQLVPIRDQSLQEEL 629
             ++AI+ ++   +Q    ++ S +P         + E+   W+++K  +  R+ SL E  
Sbjct: 991  DLVAIEAKLSD-LQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEAS 1049

Query: 630  ARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITGALEDQMNQLKQYEHNIINYK 689
              Q        QF    +    W+      IA   +  T  L +    L Q+E    N K
Sbjct: 1050 KLQ--------QFLRDLDDFQSWLSRTQTAIASEDMPNT--LTEAEKLLTQHE----NIK 1095

Query: 690  NNIDKLEGDHQLIQE 704
            N ID  E D+Q +++
Sbjct: 1096 NEIDNYEEDYQKMRD 1110



 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 63/329 (19%), Positives = 135/329 (41%), Gaps = 63/329 (19%)

Query: 366  KMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQIL- 424
            K  +++  AW+ L  A          E RR+ RL    +KFR  +   +   + ++ I  
Sbjct: 1871 KRENEVLEAWKSLLDA---------CESRRV-RLVDTGDKFRFFSMVRDLMLWMEDVIRQ 1920

Query: 425  LQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQ 484
            ++   +   ++ V  L+  H+  ++++ A  D       + + L    ++ +  + ++  
Sbjct: 1921 IEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEK-- 1978

Query: 485  KICDQWDRLGTLTQKRREALERME---KLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQD 541
                    L  LT+KR+E +++ E   + L  I ++H +F++ A+    W+ G    L  
Sbjct: 1979 --------LLQLTEKRKEMIDKWEDRWEWLRLILEVH-QFSRDASVAEAWLLGQEPYLSS 2029

Query: 542  MFIVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYST 601
              I  S++E++ LI  HE F                     EK   +++ R S+    +T
Sbjct: 2030 REIGQSVDEVEKLIKRHEAF---------------------EKSAATWDERFSALERLTT 2068

Query: 602  VTMDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIA 661
            +             +L+ +R Q  +EE  R+  +     + + +A +   W  +K E+++
Sbjct: 2069 L-------------ELLEVRRQQEEEERKRRPPSPEPSTKVSEEAESQQQWDTSKGEQVS 2115

Query: 662  RSSIQITGALEDQMNQLKQYEHNIINYKN 690
            ++ +      E    ++        NYKN
Sbjct: 2116 QNGL----PAEQGSPRVSYRSQTYQNYKN 2140



 Score = 50.8 bits (120), Expect = 5e-06
 Identities = 71/319 (22%), Positives = 128/319 (40%), Gaps = 36/319 (11%)

Query: 387 EWLLNEIR-RLERLEHLA--EKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRK 443
           E+LL  +R R +RLE     +K  Q+      W    + ++L +DY    L  V  LL+K
Sbjct: 498 EYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDY-GKHLLGVEDLLQK 556

Query: 444 HEAFESDLAAHQDRVEQIAAIAQEL----NELDYHDAVNVNDRCQKICDQWDRLGTLTQK 499
           H   E+D+    +RV  + A AQ+           D   + DR   +   +  L  L  +
Sbjct: 557 HTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAE 616

Query: 500 RREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHE 559
           RR  LE   +L         +F    A    W+    + L        +  +  L++ H 
Sbjct: 617 RRARLEESRRL--------WKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHR 668

Query: 560 QFKATLPEADGERQSIMAIQNEVEKVIQSY--NIRISSSNPYSTVTMDELRTKWDKVKQL 617
            F+  +    G  +   AI+   + + + +  + +I     Y       +R +W  ++QL
Sbjct: 669 AFEDEMSGRSGHFE--QAIKEGEDMIAEEHFGSEKIRERIIY-------IREQWANLEQL 719

Query: 618 VPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSI-QITGALEDQMN 676
             IR + L+E          L  QF A A+ I  W+ + ++ ++ S +     + +  + 
Sbjct: 720 SAIRKKRLEE--------ASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVK 771

Query: 677 QLKQYEHNIINYKNNIDKL 695
           + K     I NY+  +D L
Sbjct: 772 KHKDVAEEIANYRPTLDTL 790



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 40/237 (16%), Positives = 99/237 (41%), Gaps = 11/237 (4%)

Query: 508 EKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKAT-LP 566
           EK++E  + L       A+    W+E  +  L +    +S+  +Q  + A   ++    P
Sbjct: 288 EKMIEKYESL-------ASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKP 340

Query: 567 EADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQ 626
               E+ ++  +   ++  +++ N ++    P     + ++   W+++++    R+ +L+
Sbjct: 341 PKFTEKGNLEVLLFTIQSKMRANNQKVYM--PREGKLISDINKAWERLEKAEHERELALR 398

Query: 627 EELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQI-TGALEDQMNQLKQYEHNI 685
            EL RQ   E+L R+F  +A     W+      +++ +      A+E    + +  E +I
Sbjct: 399 NELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDI 458

Query: 686 INYKNNIDKLEGDHQLIQEALVFDNKHTNYTMEHIRVGWELLLTTIARTINEVETQI 742
             Y+  +  +    + ++     D K      +++   WE LL  +      +E  +
Sbjct: 459 AAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNL 515



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 71/322 (22%), Positives = 132/322 (40%), Gaps = 55/322 (17%)

Query: 403  AEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIA 462
            AE F Q  +  + W +G E  +   DY    LT V  LL+K +  E+ +   +  +E++ 
Sbjct: 1369 AELFTQSCADLDKWLHGLESQIQSDDY-GKDLTSVNILLKKQQMLENQMEVRKKEIEELQ 1427

Query: 463  AIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQL--HLE 520
            + AQ L++              K  D+ D       KR     +  +LLE +++   +L 
Sbjct: 1428 SQAQALSQEG------------KSTDEVD------SKRLTVQTKFMELLEPLNERKHNLL 1469

Query: 521  FAKRAAPFNN-------WMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQ 573
             +K    FN        W+   M         H+++ +Q LI  ++            ++
Sbjct: 1470 ASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTL----------QK 1519

Query: 574  SIMAIQNEVEKVIQ-SYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQEELARQ 632
             I   Q  ++ + + S NI   S    S+++ + +R +   +KQL  +  +  ++   R 
Sbjct: 1520 EIQGHQPRIDDIFERSQNIVTDS----SSLSAEAIRQRLADLKQLWGLLIEETEKRHRRL 1575

Query: 633  HANERLRRQF--AAQANAIGPWIQNKMEEIARSSIQITGALEDQMNQLKQYEHNIINYKN 690
                R ++ +  AA+A A   W+    +E+   S +     +  ++ LK  +H I+    
Sbjct: 1576 EEAHRAQQYYFDAAEAEA---WMSE--QELYMMSEEKAKDEQSAVSMLK--KHQILEQAV 1628

Query: 691  NIDKLEGDHQL--IQEALVFDN 710
              D  E  HQL     ALV D+
Sbjct: 1629 E-DYAETVHQLSKTSRALVADS 1649



 Score = 37.7 bits (86), Expect = 0.048
 Identities = 63/332 (18%), Positives = 123/332 (37%), Gaps = 48/332 (14%)

Query: 404  EKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAA 463
            +KF Q       W    E++L  +D        + +   KH+AF ++LA++++ +++I  
Sbjct: 1265 QKFLQDCQELSLWI--NEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEK 1322

Query: 464  IAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAK 523
               +L          V ++   +   W+ L + TQ + + L    K      +L   F +
Sbjct: 1323 EGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKA-----EL---FTQ 1374

Query: 524  RAAPFNNWMEGAMEDLQ------DMFIVH------------------SIEEIQSLITAHE 559
              A  + W+ G    +Q      D+  V+                   IEE+QS   A  
Sbjct: 1375 SCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALS 1434

Query: 560  QFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMD-ELRTKWDKVKQLV 618
            Q   +  E D +R ++     E+ + +      + +S        D E    W  V + +
Sbjct: 1435 QEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILW--VGERM 1492

Query: 619  PI-----RDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITGALED 673
            P+        +LQ        N+ L+++       I    +     +  SS     A+  
Sbjct: 1493 PLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQ 1552

Query: 674  QMNQLKQYEHNIINYKNNIDKLEGDHQLIQEA 705
            ++  LKQ       +   I++ E  H+ ++EA
Sbjct: 1553 RLADLKQL------WGLLIEETEKRHRRLEEA 1578



 Score = 36.2 bits (82), Expect = 0.14
 Identities = 30/143 (20%), Positives = 56/143 (39%), Gaps = 7/143 (4%)

Query: 490 WDRLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIE 549
           W+RL     +R  AL       E ++QL   F ++AA    W+      +        + 
Sbjct: 383 WERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLP 442

Query: 550 EIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRT 609
            +++    HE  +  +   +   Q+++A+  E+E        RI       T   D +  
Sbjct: 443 AVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRI-------TARKDNVIR 495

Query: 610 KWDKVKQLVPIRDQSLQEELARQ 632
            W+ + +L+  R Q L+  L  Q
Sbjct: 496 LWEYLLELLRARRQRLEMNLGLQ 518



 Score = 36.2 bits (82), Expect = 0.14
 Identities = 39/203 (19%), Positives = 83/203 (40%), Gaps = 23/203 (11%)

Query: 437  VRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHD-AVNVNDRCQKICDQWDRLGT 495
            V  L R H  FE D+ A   +V Q+   A  L      D A ++  R  ++ + W  L  
Sbjct: 1826 VETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLD 1885

Query: 496  LTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLI 555
              + RR       +L++T D+    F         WME  +  ++       +  ++ L+
Sbjct: 1886 ACESRR------VRLVDTGDK--FRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLM 1937

Query: 556  TAHEQFKATLPEADGE-------RQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELR 608
              H+  KA +   +          +S++A ++   + I+   ++++         +D+  
Sbjct: 1938 NNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKR---KEMIDKWE 1994

Query: 609  TKWDKVKQLVPI----RDQSLQE 627
             +W+ ++ ++ +    RD S+ E
Sbjct: 1995 DRWEWLRLILEVHQFSRDASVAE 2017


>gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo
           sapiens]
          Length = 2364

 Score =  431 bits (1108), Expect = e-120
 Identities = 226/475 (47%), Positives = 314/475 (66%), Gaps = 8/475 (1%)

Query: 37  EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPKPDRGKMRFHK 96
           E  Q+KTFT W NSHL +   +I ++  D R+G  L+ LLEV+SGERLPKP +G+MR H 
Sbjct: 53  EAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKPTKGRMRIHC 112

Query: 97  IANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVE------E 150
           + NV+KAL ++  + V L ++G+ +IVDGN ++TLG+IWTIILRF IQDISVE      +
Sbjct: 113 LENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDNKEK 172

Query: 151 TSAKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPDLIDYSKLNKDDPIG 210
            SAK+ LLLWCQ KTA Y NVNI NF TSW+DG+   ALIH+HRPDLID+ KL K +   
Sbjct: 173 KSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSNAHY 232

Query: 211 NINLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQAETAANRIC 270
           N+  A  +AE+HL + K+LD EDI +   PDE++I+TYV  +YH F+  +       RI 
Sbjct: 233 NLQNAFNLAEQHLGLTKLLDPEDI-SVDHPDEKSIITYVVTYYHYFSKMKALAVEGKRIG 291

Query: 271 KVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKH 330
           KVL    E E+++E+YE LAS+LLEWI +TI  L NR    ++  +Q++L+ F  YR   
Sbjct: 292 KVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVE 351

Query: 331 KPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLL 390
           KPPK  EK  LE+   T+Q+K+R +N+  +MP EGK++SDI  AW+RLE+AE   E  L 
Sbjct: 352 KPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALR 411

Query: 391 NEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESD 450
           NE+ R E+LE LA +F +KA+  ETW   + Q L+ +D     L  V A  +KHEA E+D
Sbjct: 412 NELIRQEKLEQLARRFDRKAAMRETW-LSENQRLVSQDNFGFDLPAVEAATKKHEAIETD 470

Query: 451 LAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALE 505
           +AA+++RV+ + A+A+EL   +YHD   +  R   +   W+ L  L + RR+ LE
Sbjct: 471 IAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLE 525



 Score = 76.6 bits (187), Expect = 9e-14
 Identities = 78/316 (24%), Positives = 135/316 (42%), Gaps = 35/316 (11%)

Query: 360 FMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAE--KFRQKASTHETWA 417
           + P + +++ D      R+   E  Y+E       R  RLE      KF  + +  E W 
Sbjct: 601 YKPCDPQVIRD------RVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWI 654

Query: 418 YGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAV 477
             KE+IL   DY    LT V  LL KH AFE +++      EQ     +++   ++  + 
Sbjct: 655 REKEKILSSDDY-GKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSE 713

Query: 478 NVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAME 537
            + +R   I +QW  L  L+  R+       K LE    LH +F   A   + WM   ++
Sbjct: 714 KIRERIIYIREQWANLEQLSAIRK-------KRLEEASLLH-QFQADADDIDAWMLDILK 765

Query: 538 DLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSN 597
            +    + H     QSL+  H   K    E    R ++  +  +   + Q +     + +
Sbjct: 766 IVSSSDVGHDEYSTQSLVKKH---KDVAEEIANYRPTLDTLHEQASALPQEH-----AES 817

Query: 598 PYSTVTMDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKM 657
           P     +  +  ++ +V +L  +R Q+LQ+ LA       L + F ++A+A   WI  K 
Sbjct: 818 PDVRGRLSGIEERYKEVAELTRLRKQALQDTLA-------LYKMF-SEADACELWIDEKE 869

Query: 658 EEIARSSIQITGALED 673
           + +  +++QI   LED
Sbjct: 870 QWL--NNMQIPEKLED 883



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 104/552 (18%), Positives = 209/552 (37%), Gaps = 82/552 (14%)

Query: 172  NIQNFHTSWKDGLGLCALIHRHRPD-------LIDYSKLNKDDPIGNINLAME-IAEKHL 223
            N++      K  L   +L+H+ + D       ++D  K+     +G+   + + + +KH 
Sbjct: 728  NLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHK 787

Query: 224  DIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQAETAANRICKVLAVNQENERLM 283
            D+     AE+I N  +P    +    S      A +       + I       +E  + +
Sbjct: 788  DV-----AEEIANY-RPTLDTLHEQASALPQEHAESPDVRGRLSGI-------EERYKEV 834

Query: 284  EEYERLASELLE-----------------WIRRTIPWLENRTPEKTMQAMQKKLEDFR-- 324
             E  RL  + L+                 WI     WL N         + +KLED    
Sbjct: 835  AELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNN-------MQIPEKLEDLEVI 887

Query: 325  DYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSD-IAGAWQRLEQAEK 383
             +R +   P++  +       N +  +L  S  P+    E K   D +   W +  +   
Sbjct: 888  QHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPS--EKEIKAQQDKLNTRWSQFRELVD 945

Query: 384  GYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRK 443
              ++ LL+ +          + +  + +  ++W   K +++         L  V AL RK
Sbjct: 946  RKKDALLSALS--------IQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRK 997

Query: 444  HEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREA 503
                E DL A + ++  +   A++L       A  +  R  +I D W+ + T  + R  +
Sbjct: 998  LTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREAS 1057

Query: 504  LERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKA 563
            L    KL +        F +    F +W+      +    + +++ E + L+T HE  K 
Sbjct: 1058 LGEASKLQQ--------FLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIK- 1108

Query: 564  TLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQ 623
               E D   +    +++  E V Q    +  +   +    +  L T W+++ ++     +
Sbjct: 1109 --NEIDNYEEDYQKMRDMGEMVTQG---QTDAQYMFLRQRLQALDTGWNELHKMW----E 1159

Query: 624  SLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITGALEDQMNQLKQYEH 683
            + Q  L++ HA ++  R    QA A   ++ N+   +A + +  T  LE     +K+ E 
Sbjct: 1160 NRQNLLSQSHAYQQFLRD-TKQAEA---FLNNQEYVLAHTEMPTT--LEGAEAAIKKQED 1213

Query: 684  NIINYKNNIDKL 695
             +     N +K+
Sbjct: 1214 FMTTMDANEEKI 1225



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 89/435 (20%), Positives = 169/435 (38%), Gaps = 60/435 (13%)

Query: 278  ENERLMEEYERLASELLEW---IRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHKPPK 334
            E   L+ +++  A ++  W   I + +   +    E + Q++ KK +D  +    ++P  
Sbjct: 741  EEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRP-- 798

Query: 335  VQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIR 394
                        TL T   +  + + +P E     D+ G    +E+  K   E  L  +R
Sbjct: 799  ------------TLDT---LHEQASALPQEHAESPDVRGRLSGIEERYKEVAE--LTRLR 841

Query: 395  RLERLEHLA-EKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAA 453
            +    + LA  K   +A   E W   KEQ L         L ++  +  + E+ E ++  
Sbjct: 842  KQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPE-KLEDLEVIQHRFESLEPEMNN 900

Query: 454  HQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLET 513
               RV  +  IA++L    +     +  +  K+  +W +   L  ++++AL  +  L  +
Sbjct: 901  QASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDAL--LSAL--S 956

Query: 514  IDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQ 573
            I   HLE  +      +W+    +          IE  Q L        A   +  G  +
Sbjct: 957  IQNYHLECNET----KSWIREKTK---------VIESTQDLGNDLAGVMALQRKLTGMER 1003

Query: 574  SIMAIQNEVEKVIQSYNIRISSSNPYSTVT----MDELRTKWDKVKQLVPIRDQSLQEEL 629
             ++AI+ ++   +Q    ++ S +P         + E+   W+++K  +  R+ SL E  
Sbjct: 1004 DLVAIEAKLSD-LQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEAS 1062

Query: 630  ARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITGALEDQMNQLKQYEHNIINYK 689
              Q        QF    +    W+      IA   +  T  L +    L Q+E    N K
Sbjct: 1063 KLQ--------QFLRDLDDFQSWLSRTQTAIASEDMPNT--LTEAEKLLTQHE----NIK 1108

Query: 690  NNIDKLEGDHQLIQE 704
            N ID  E D+Q +++
Sbjct: 1109 NEIDNYEEDYQKMRD 1123



 Score = 50.8 bits (120), Expect = 5e-06
 Identities = 71/319 (22%), Positives = 128/319 (40%), Gaps = 36/319 (11%)

Query: 387 EWLLNEIR-RLERLEHLA--EKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRK 443
           E+LL  +R R +RLE     +K  Q+      W    + ++L +DY    L  V  LL+K
Sbjct: 511 EYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDY-GKHLLGVEDLLQK 569

Query: 444 HEAFESDLAAHQDRVEQIAAIAQEL----NELDYHDAVNVNDRCQKICDQWDRLGTLTQK 499
           H   E+D+    +RV  + A AQ+           D   + DR   +   +  L  L  +
Sbjct: 570 HTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAE 629

Query: 500 RREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHE 559
           RR  LE   +L         +F    A    W+    + L        +  +  L++ H 
Sbjct: 630 RRARLEESRRL--------WKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHR 681

Query: 560 QFKATLPEADGERQSIMAIQNEVEKVIQSY--NIRISSSNPYSTVTMDELRTKWDKVKQL 617
            F+  +    G  +   AI+   + + + +  + +I     Y       +R +W  ++QL
Sbjct: 682 AFEDEMSGRSGHFE--QAIKEGEDMIAEEHFGSEKIRERIIY-------IREQWANLEQL 732

Query: 618 VPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSI-QITGALEDQMN 676
             IR + L+E          L  QF A A+ I  W+ + ++ ++ S +     + +  + 
Sbjct: 733 SAIRKKRLEE--------ASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVK 784

Query: 677 QLKQYEHNIINYKNNIDKL 695
           + K     I NY+  +D L
Sbjct: 785 KHKDVAEEIANYRPTLDTL 803



 Score = 50.4 bits (119), Expect = 7e-06
 Identities = 58/304 (19%), Positives = 128/304 (42%), Gaps = 59/304 (19%)

Query: 366  KMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQIL- 424
            K  +++  AW+ L  A          E RR+ RL    +KFR  +   +   + ++ I  
Sbjct: 1884 KRENEVLEAWKSLLDA---------CESRRV-RLVDTGDKFRFFSMVRDLMLWMEDVIRQ 1933

Query: 425  LQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQ 484
            ++   +   ++ V  L+  H+  ++++ A  D       + + L    ++ +  + ++  
Sbjct: 1934 IEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEK-- 1991

Query: 485  KICDQWDRLGTLTQKRREALERME---KLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQD 541
                    L  LT+KR+E +++ E   + L  I ++H +F++ A+    W+ G    L  
Sbjct: 1992 --------LLQLTEKRKEMIDKWEDRWEWLRLILEVH-QFSRDASVAEAWLLGQEPYLSS 2042

Query: 542  MFIVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYST 601
              I  S++E++ LI  HE F                     EK   +++ R S+    +T
Sbjct: 2043 REIGQSVDEVEKLIKRHEAF---------------------EKSAATWDERFSALERLTT 2081

Query: 602  VTMDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIA 661
            +             +L+ +R Q  +EE  R+  +     + + +A +   W  +K E+++
Sbjct: 2082 L-------------ELLEVRRQQEEEERKRRPPSPEPSTKVSEEAESQQQWDTSKGEQVS 2128

Query: 662  RSSI 665
            ++ +
Sbjct: 2129 QNGL 2132



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 40/237 (16%), Positives = 99/237 (41%), Gaps = 11/237 (4%)

Query: 508 EKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKAT-LP 566
           EK++E  + L       A+    W+E  +  L +    +S+  +Q  + A   ++    P
Sbjct: 301 EKMIEKYESL-------ASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKP 353

Query: 567 EADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQ 626
               E+ ++  +   ++  +++ N ++    P     + ++   W+++++    R+ +L+
Sbjct: 354 PKFTEKGNLEVLLFTIQSKMRANNQKVYM--PREGKLISDINKAWERLEKAEHERELALR 411

Query: 627 EELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQI-TGALEDQMNQLKQYEHNI 685
            EL RQ   E+L R+F  +A     W+      +++ +      A+E    + +  E +I
Sbjct: 412 NELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDI 471

Query: 686 INYKNNIDKLEGDHQLIQEALVFDNKHTNYTMEHIRVGWELLLTTIARTINEVETQI 742
             Y+  +  +    + ++     D K      +++   WE LL  +      +E  +
Sbjct: 472 AAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNL 528



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 71/322 (22%), Positives = 132/322 (40%), Gaps = 55/322 (17%)

Query: 403  AEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIA 462
            AE F Q  +  + W +G E  +   DY    LT V  LL+K +  E+ +   +  +E++ 
Sbjct: 1382 AELFTQSCADLDKWLHGLESQIQSDDY-GKDLTSVNILLKKQQMLENQMEVRKKEIEELQ 1440

Query: 463  AIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQL--HLE 520
            + AQ L++              K  D+ D       KR     +  +LLE +++   +L 
Sbjct: 1441 SQAQALSQEG------------KSTDEVD------SKRLTVQTKFMELLEPLNERKHNLL 1482

Query: 521  FAKRAAPFNN-------WMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQ 573
             +K    FN        W+   M         H+++ +Q LI  ++            ++
Sbjct: 1483 ASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTL----------QK 1532

Query: 574  SIMAIQNEVEKVIQ-SYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQEELARQ 632
             I   Q  ++ + + S NI   S    S+++ + +R +   +KQL  +  +  ++   R 
Sbjct: 1533 EIQGHQPRIDDIFERSQNIVTDS----SSLSAEAIRQRLADLKQLWGLLIEETEKRHRRL 1588

Query: 633  HANERLRRQF--AAQANAIGPWIQNKMEEIARSSIQITGALEDQMNQLKQYEHNIINYKN 690
                R ++ +  AA+A A   W+    +E+   S +     +  ++ LK  +H I+    
Sbjct: 1589 EEAHRAQQYYFDAAEAEA---WMSE--QELYMMSEEKAKDEQSAVSMLK--KHQILEQAV 1641

Query: 691  NIDKLEGDHQL--IQEALVFDN 710
              D  E  HQL     ALV D+
Sbjct: 1642 E-DYAETVHQLSKTSRALVADS 1662



 Score = 37.7 bits (86), Expect = 0.048
 Identities = 63/332 (18%), Positives = 123/332 (37%), Gaps = 48/332 (14%)

Query: 404  EKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAA 463
            +KF Q       W    E++L  +D        + +   KH+AF ++LA++++ +++I  
Sbjct: 1278 QKFLQDCQELSLWI--NEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEK 1335

Query: 464  IAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAK 523
               +L          V ++   +   W+ L + TQ + + L    K      +L   F +
Sbjct: 1336 EGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKA-----EL---FTQ 1387

Query: 524  RAAPFNNWMEGAMEDLQ------DMFIVH------------------SIEEIQSLITAHE 559
              A  + W+ G    +Q      D+  V+                   IEE+QS   A  
Sbjct: 1388 SCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALS 1447

Query: 560  QFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMD-ELRTKWDKVKQLV 618
            Q   +  E D +R ++     E+ + +      + +S        D E    W  V + +
Sbjct: 1448 QEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILW--VGERM 1505

Query: 619  PI-----RDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITGALED 673
            P+        +LQ        N+ L+++       I    +     +  SS     A+  
Sbjct: 1506 PLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQ 1565

Query: 674  QMNQLKQYEHNIINYKNNIDKLEGDHQLIQEA 705
            ++  LKQ       +   I++ E  H+ ++EA
Sbjct: 1566 RLADLKQL------WGLLIEETEKRHRRLEEA 1591



 Score = 36.2 bits (82), Expect = 0.14
 Identities = 30/143 (20%), Positives = 56/143 (39%), Gaps = 7/143 (4%)

Query: 490 WDRLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIE 549
           W+RL     +R  AL       E ++QL   F ++AA    W+      +        + 
Sbjct: 396 WERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLP 455

Query: 550 EIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRT 609
            +++    HE  +  +   +   Q+++A+  E+E        RI       T   D +  
Sbjct: 456 AVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRI-------TARKDNVIR 508

Query: 610 KWDKVKQLVPIRDQSLQEELARQ 632
            W+ + +L+  R Q L+  L  Q
Sbjct: 509 LWEYLLELLRARRQRLEMNLGLQ 531



 Score = 36.2 bits (82), Expect = 0.14
 Identities = 39/203 (19%), Positives = 83/203 (40%), Gaps = 23/203 (11%)

Query: 437  VRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHD-AVNVNDRCQKICDQWDRLGT 495
            V  L R H  FE D+ A   +V Q+   A  L      D A ++  R  ++ + W  L  
Sbjct: 1839 VETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLD 1898

Query: 496  LTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLI 555
              + RR       +L++T D+    F         WME  +  ++       +  ++ L+
Sbjct: 1899 ACESRR------VRLVDTGDK--FRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLM 1950

Query: 556  TAHEQFKATLPEADGE-------RQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELR 608
              H+  KA +   +          +S++A ++   + I+   ++++         +D+  
Sbjct: 1951 NNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKR---KEMIDKWE 2007

Query: 609  TKWDKVKQLVPI----RDQSLQE 627
             +W+ ++ ++ +    RD S+ E
Sbjct: 2008 DRWEWLRLILEVHQFSRDASVAE 2030


>gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens]
          Length = 2390

 Score =  431 bits (1107), Expect = e-120
 Identities = 260/689 (37%), Positives = 386/689 (56%), Gaps = 51/689 (7%)

Query: 8   VQYNYVYDEDEYMIQEEEWDRDLLLDPAWEKQ------------QRKTFTAWCNSHLRKA 55
           +Q  Y    + + + + +WD D      +E+             Q+KTFT W NSHL + 
Sbjct: 15  IQGQYSDINNRWDLPDSDWDNDSSSARLFERSRIKALADEREAVQKKTFTKWVNSHLARV 74

Query: 56  GTQIENIEEDFRNGLKLMLLLEVISGERLPKPDRGKMRFHKIANVNKALDYIASKGVKLV 115
             ++ ++  D R+G  L+ LLEV+SGE LPKP +G+MR H + NV+KAL ++  + V L 
Sbjct: 75  TCRVGDLYSDLRDGRNLLRLLEVLSGEILPKPTKGRMRIHCLENVDKALQFLKEQKVHLE 134

Query: 116 SIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVE------ETSAKEGLLLWCQRKTAPYR 169
           ++G+ +IVDGN ++TLG++WTIILRF IQDISVE      + SAK+ LLLWCQ KTA Y 
Sbjct: 135 NMGSHDIVDGNHRLTLGLVWTIILRFQIQDISVETEDNKEKKSAKDALLLWCQMKTAGYP 194

Query: 170 NVNIQNFHTSWKDGLGLCALIHRHRPDLIDYSKLNKDDPIGNINLAMEIAEKHLDIPKML 229
           NVN+ NF TSW+DGL   A++H+HRPDL+D+  L K +   N+  A  +AEK L + K+L
Sbjct: 195 NVNVHNFTTSWRDGLAFNAIVHKHRPDLLDFESLKKCNAHYNLQNAFNLAEKELGLTKLL 254

Query: 230 DAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQAETAANRICKVLAVNQENERLMEEYERL 289
           D ED VN  +PDE++I+TYV+ +YH F+  +       RI KVL    E ERL+E+YE L
Sbjct: 255 DPED-VNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDHAMEAERLVEKYESL 313

Query: 290 ASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHKPPKVQEKCQLEINFNTLQ 349
           ASELL+WI +TI  L +R    ++  +Q +L+ F  YR   KPPK  EK  LE+   T+Q
Sbjct: 314 ASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQ 373

Query: 350 TKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQK 409
           +KLR +N+  + P EG+++SDI  AW+RLE+AE   E  L  E+ R E+LE LA +F +K
Sbjct: 374 SKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQLAARFDRK 433

Query: 410 ASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELN 469
           A+  ETW   + Q L+ +D     L  V A +RKHEA E+D+ A+  RV+ + A+A EL 
Sbjct: 434 AAMRETW-LSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELA 492

Query: 470 ELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREAL---ERMEKLLETIDQLHLEFAKRAA 526
              YHD   +  R   +   WD L  +   RRE L     ++K+ +  D L+L       
Sbjct: 493 AERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQ--DLLYL------- 543

Query: 527 PFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVI 586
              +WME     LQ   +   +  ++ L+  HE     L EAD      +A+Q E  + +
Sbjct: 544 --MDWMEEMKGRLQSQDLGRHLAGVEDLLQLHE-----LVEAD------IAVQAERVRAV 590

Query: 587 QSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRR--QFAA 644
            +  +R    NP       + +   ++V +L    +   +   AR+   E  RR  +F  
Sbjct: 591 SASALRF--CNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLW 648

Query: 645 QANAIGPWIQNKMEEIARSSI--QITGAL 671
           +      W++ +   +A +     +TGAL
Sbjct: 649 EVGEAEAWVREQQHLLASADTGRDLTGAL 677



 Score = 57.4 bits (137), Expect = 6e-08
 Identities = 105/549 (19%), Positives = 211/549 (38%), Gaps = 75/549 (13%)

Query: 270  CKVLAVNQENERLMEEYERLASELLEWIRRTIPW---LENRTPEKTMQAMQKKLEDFRDY 326
            C+ L  ++E  +   + E    E+L W+   +P    +E+     ++Q + KK +  +  
Sbjct: 1481 CRRLQASREQHQFHRDVE---DEIL-WVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKE 1536

Query: 327  RRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYE 386
             + H+P                   LR   R     + G  ++++   W+RL     G+E
Sbjct: 1537 IQGHEPRIAD---------------LRERQRALGAAAAGPELAELQEMWKRL-----GHE 1576

Query: 387  EWLLNEIRRLERLEHL--AEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKH 444
              L     R +RLE    A++F + A+  E W  G++++ +    ++      +A ++KH
Sbjct: 1577 LEL-----RGKRLEDALRAQQFYRDAAEAEAWM-GEQELHMMGQEKAKDELSAQAEVKKH 1630

Query: 445  EAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREAL 504
            +  E  LA +   + Q+AA +Q++ + ++ ++  ++ R  ++   +  L  L  +RRE L
Sbjct: 1631 QVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERL 1690

Query: 505  ERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKAT 564
            +   +L +   +L             W++          +    E +  L     +F   
Sbjct: 1691 QEHLRLCQLRRELD--------DLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRD 1742

Query: 565  LPEADGER-QSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQ 623
                  ER  S  A+ N +  +   +  R + +        D L   W  + +L+  R Q
Sbjct: 1743 TSTIGQERVDSANALANGL--IAGGHAARATVAE-----WKDSLNEAWADLLELLDTRGQ 1795

Query: 624  SLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITGALEDQMNQLKQYEH 683
             L      Q      R+  A         +Q+K +++   + +   A E    +   YEH
Sbjct: 1796 VLAAAYELQRFLHGARQALAR--------VQHKQQQLPDGTGRDLNAAEALQRRHCAYEH 1847

Query: 684  NIINYKNNIDKLEGDHQLIQEALVFDN-KHTNYTMEHIRVGW-----------ELLLTTI 731
            +I      + +++ D   +Q+A   D  +     M+ +   W           +LLL T 
Sbjct: 1848 DIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTT 1907

Query: 732  --ARTINEVETQILTRDAKGITQEQMNEFR--ASFNHFDRRKNGLMDHEDFRACLISMGY 787
               R    V   +L  D   +  +     R  +S +   + + G+    + RA   S   
Sbjct: 1908 DKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCI 1967

Query: 788  DLGEAEFAR 796
            D+G+   AR
Sbjct: 1968 DMGKELLAR 1976



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 85/418 (20%), Positives = 155/418 (37%), Gaps = 64/418 (15%)

Query: 271 KVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKH 330
           +++A  +E   L  E +++  +LL      + W+E        Q + + L    D  + H
Sbjct: 518 QMVAARRERLLLNLELQKVFQDLLY----LMDWMEEMKGRLQSQDLGRHLAGVEDLLQLH 573

Query: 331 KPPKVQEKCQLEINFNTLQTKLRISNR-PAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWL 389
           +  +     Q E       + LR  N    + P + ++VS+      R+ + E+ YE   
Sbjct: 574 ELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSE------RVAKLEQSYEALC 627

Query: 390 LNEIRRLERLEHLAE--KFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAF 447
                R  RLE      +F  +    E W   ++ +L   D     LT    LL KH A 
Sbjct: 628 ELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASAD-TGRDLTGALRLLNKHTAL 686

Query: 448 ESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERM 507
             +++     ++      Q+L    +  A   + R  ++  QW+RL  L ++R + L + 
Sbjct: 687 RGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQA 746

Query: 508 EKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAH----EQFKA 563
             L         +F   A     W+  A+  +    + H     Q+L   H    E+ ++
Sbjct: 747 ASL--------YQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRS 798

Query: 564 TLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQ 623
             P  D  R+   A+   + +                            +V+  VP  ++
Sbjct: 799 HRPTLDALREQAAALPPTLSRT--------------------------PEVQGRVPTLER 832

Query: 624 SLQEELARQHANERLRRQFAA--------QANAIGPWIQNKMEEIARSSIQITGALED 673
             +E  AR  A ER R   AA        +A A G W++ K + +  + + +   LED
Sbjct: 833 HYEELQAR--AGERARALEAALALYTMLSEAGACGLWVEEKEQWL--NGLALPERLED 886



 Score = 53.5 bits (127), Expect = 8e-07
 Identities = 68/329 (20%), Positives = 136/329 (41%), Gaps = 39/329 (11%)

Query: 377  RLEQAEKGYEEWLLNEIRRLERLEHLA--EKFRQKASTHETWAYGKEQILLQKDYESASL 434
            RL + + G+E+      RR E L      + F +     + W  G+ Q  +  +   A+L
Sbjct: 1039 RLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWL-GRTQTAVASEEGPATL 1097

Query: 435  TEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHD--AVNVNDRCQKICDQWDR 492
             E  ALL +H A   ++   Q    ++ A+ +E+   D  D   + +  R + +   W+ 
Sbjct: 1098 PEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTR-DQADPQCLFLRQRLEALGTGWEE 1156

Query: 493  LGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVH-----S 547
            LG + + R+  L +         Q  L  A++A       EG +   Q+  + H     +
Sbjct: 1157 LGRMWESRQGRLAQAHGF-----QGFLRDARQA-------EGVLSS-QEYVLSHTEMPGT 1203

Query: 548  IEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDEL 607
            ++   + I   E F +T+ +A+GER         +  ++++    +S  N    +  D++
Sbjct: 1204 LQAADAAIKKLEDFMSTM-DANGER---------IHGLLEAGRQLVSEGN----IHADKI 1249

Query: 608  RTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQI 667
            R K D +++       + Q+ L R   N R ++ F    + +  WI  KM      S   
Sbjct: 1250 REKADSIERRHKKNQDAAQQFLGRLRDN-REQQHFLQDCHELKLWIDEKMLTAQDVSYDE 1308

Query: 668  TGALEDQMNQLKQYEHNIINYKNNIDKLE 696
               L  +  + + +   +   K+ +DK++
Sbjct: 1309 ARNLHTKWQKHQAFMAELAANKDWLDKVD 1337



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 38/183 (20%), Positives = 75/183 (40%), Gaps = 10/183 (5%)

Query: 396  LERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQ 455
            L RL    E+       HE   +  E++L  +D        +    +KH+AF ++LAA++
Sbjct: 1271 LGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARNLHTKWQKHQAFMAELAANK 1330

Query: 456  DRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETID 515
            D ++++    +EL          V+++ + +  +WD L T TQ +  +L          D
Sbjct: 1331 DWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSL---------FD 1381

Query: 516  QLHLE-FAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQS 574
                E FA+      +W+E     L        +  +  L+   +  +  +   + E ++
Sbjct: 1382 ANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEA 1441

Query: 575  IMA 577
            I A
Sbjct: 1442 IQA 1444



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 39/203 (19%), Positives = 91/203 (44%), Gaps = 27/203 (13%)

Query: 365  GKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQIL 424
            G+ +  +A AW +L+ +     + LL+            +KFR   +  E   +  +++ 
Sbjct: 1879 GRHMQAVAEAWAQLQGSSAARRQLLLDT----------TDKFRFFKAVRELMLW-MDEVN 1927

Query: 425  LQKDYESA--SLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDR 482
            LQ D +     ++    +++  +  ++++ A  DR      + +EL    ++ A  ++++
Sbjct: 1928 LQMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEK 1987

Query: 483  CQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHLE---FAKRAAPFNNWMEGAMEDL 539
                      L  L  +R+E  E+ ++ ++ + QL LE   F + A     W+      +
Sbjct: 1988 ----------LSQLQARRQETAEKWQEKMDWL-QLVLEVLVFGRDAGMAEAWLCSQEPLV 2036

Query: 540  QDMFIVHSIEEIQSLITAHEQFK 562
            +   +  +++E++SLI  HE F+
Sbjct: 2037 RSAELGCTVDEVESLIKRHEAFQ 2059



 Score = 33.5 bits (75), Expect = 0.91
 Identities = 26/100 (26%), Positives = 48/100 (48%), Gaps = 14/100 (14%)

Query: 376  QRLEQAEKGYE--EWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESAS 433
            +R E AEK  E  +WL   +  L         F + A   E W   +E ++   +    +
Sbjct: 1994 RRQETAEKWQEKMDWLQLVLEVLV--------FGRDAGMAEAWLCSQEPLVRSAEL-GCT 2044

Query: 434  LTEVRALLRKHEAFESDLAAHQDR---VEQIAAIAQELNE 470
            + EV +L+++HEAF+    A ++R   +E++ A+ +   E
Sbjct: 2045 VDEVESLIKRHEAFQKSAVAWEERFCALEKLTALEEREKE 2084


>gi|67782321 spectrin beta isoform a [Homo sapiens]
          Length = 2328

 Score =  416 bits (1070), Expect = e-116
 Identities = 252/653 (38%), Positives = 367/653 (56%), Gaps = 38/653 (5%)

Query: 15  DEDEYMIQEEEWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLML 74
           D D    +  E  R   L    E  Q+KTFT W NSHL +   +I ++ +D R+G  L+ 
Sbjct: 31  DNDNSSARLFERSRIKALADEREVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIK 90

Query: 75  LLEVISGERLPKPDRGKMRFHKIANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTLGMI 134
           LLEV+SGE LPKP +GKMR H + NV+KAL ++  + V L ++G+ +IVDGN ++ LG+I
Sbjct: 91  LLEVLSGEMLPKPTKGKMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLI 150

Query: 135 WTIILRFAIQDISV------EETSAKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCA 188
           WTIILRF IQDI V      E  SAK+ LLLWCQ KTA Y +VN+ NF +SWKDGL   A
Sbjct: 151 WTIILRFQIQDIVVQTQEGRETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNA 210

Query: 189 LIHRHRPDLIDYSKLNKDDPIGNINLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTY 248
           LIH+HRPDLID+ KL   +   N+  A  +AE+ L I  +LD ED+  T  PDE++I+TY
Sbjct: 211 LIHKHRPDLIDFDKLKDSNARHNLEHAFNVAERQLGIIPLLDPEDVF-TENPDEKSIITY 269

Query: 249 VSCFYHAFAGAEQAETAANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRT 308
           V  FYH F+  +       R+ KV+    E E+++E+Y  LAS+LL WI +TI  L +R 
Sbjct: 270 VVAFYHYFSKMKVLAVEGKRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRK 329

Query: 309 PEKTMQAMQKKLEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMV 368
              ++  +Q++L+ F  YR   KPPK QEK  LE+   T+Q+++R +N+  + P +GK+V
Sbjct: 330 FANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLV 389

Query: 369 SDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKD 428
           SDI  AW+ LE+AE   E  L NE+ R E+LE LA +F +KA+  ETW   + Q L+ +D
Sbjct: 390 SDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETW-LSENQRLVAQD 448

Query: 429 YESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICD 488
                L  V A  +KHEA E+D AA+++RV  +  +AQEL + +YHD   +  R   I  
Sbjct: 449 NFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILR 508

Query: 489 QWDRLGTLTQKRREALE---RMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIV 545
            W  L  L Q RR+ LE    ++KL +  D LH           +WM+     L      
Sbjct: 509 LWSYLQELLQSRRQRLETTLALQKLFQ--DMLH---------SIDWMDEIKAHLLSAEFG 557

Query: 546 HSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMD 605
             + E++ L+  H+     L EAD      +AIQ +  K I +  ++ +    Y      
Sbjct: 558 KHLLEVEDLLQKHK-----LMEAD------IAIQGDKVKAITAATLKFTEGKGYQPCDPQ 606

Query: 606 ELRTKWDKVKQLVPIRDQSLQEELARQHANERLRR--QFAAQANAIGPWIQNK 656
            ++   D++  L    ++       R+   E+ +R  +F  + +    WI+ K
Sbjct: 607 VIQ---DRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEK 656



 Score = 71.6 bits (174), Expect = 3e-12
 Identities = 98/459 (21%), Positives = 179/459 (38%), Gaps = 44/459 (9%)

Query: 292 ELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHKPPKVQEKCQLEINFNTLQTK 351
           +L + +  +I W++            K L +  D  +KHK  +     Q +         
Sbjct: 532 KLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAAT 591

Query: 352 LRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAE--KFRQK 409
           L+ +    + P + +++ D      R+   E+ +EE       R  +LE      KF  +
Sbjct: 592 LKFTEGKGYQPCDPQVIQD------RISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWE 645

Query: 410 ASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELN 469
               E+W   KEQI    DY    LT V  L RKH+AFE +L      +EQI   A  + 
Sbjct: 646 MDEAESWIKEKEQIYSSLDY-GKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMV 704

Query: 470 ELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFN 529
                    +  R +++  QWD+L  L    ++ L+  E           +F   A    
Sbjct: 705 ARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENF--------FQFQGDADDLK 756

Query: 530 NWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSY 589
            W++ A   L    +       ++L   H+ F   L E+ G       +   +E+  Q +
Sbjct: 757 AWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRG-------VMEHLEQQAQGF 809

Query: 590 NIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAI 649
                 S P  T  +  LR  + +V     +R Q LQE L        L   F  + +A 
Sbjct: 810 PEEFRDS-PDVTHRLQALRELYQQVVAQADLRQQRLQEAL-------DLYTVF-GETDAC 860

Query: 650 GPWIQNKMEEIARSSIQITGALEDQMNQLKQYEHNIIN--YKNNIDKLEGDHQLIQEALV 707
             W+  K + +A   +++   LED   ++ Q+  +I++   K  + +++G + L   +LV
Sbjct: 861 ELWMGEKEKWLA--EMEMPDTLEDL--EVVQHRFDILDQEMKTLMTQIDGVN-LAANSLV 915

Query: 708 FD----NKHTNYTMEHIRVGWELLLTTIARTINEVETQI 742
                 ++      +H+   W+   T ++     V++ +
Sbjct: 916 ESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSAL 954



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 62/303 (20%), Positives = 129/303 (42%), Gaps = 34/303 (11%)

Query: 416  WAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHD 475
            W   K +++         L  + A+ RK    E D+AA Q RV+ +   +Q+L +     
Sbjct: 969  WITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQ 1028

Query: 476  AVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGA 535
              ++  R + + + W  L       +++L+  E LL  + QL   F +    F  W+   
Sbjct: 1029 KEDIGQRQKHLEELWQGL-------QQSLQGQEDLLGEVSQLQ-AFLQDLDDFQAWLSIT 1080

Query: 536  MEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISS 595
             + +    +  S+ E + L+  H   K    E DG + S   ++   EKVIQ        
Sbjct: 1081 QKAVASEDMPESLPEAEQLLQQHAGIK---DEIDGHQDSYQRVKESGEKVIQ------GQ 1131

Query: 596  SNPYSTV---TMDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPW 652
            ++P   +    ++ L T W+ + ++   R  +L + L  Q   +  ++  A  +N     
Sbjct: 1132 TDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSN----- 1186

Query: 653  IQNKMEEIARSSIQITGALEDQMNQLKQYEHNIINYKNNIDK----LEGDHQLIQEALVF 708
                 +E   + ++   +LE     ++++E  + + +NN DK    ++  ++L+ E  ++
Sbjct: 1187 -----QEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLY 1241

Query: 709  DNK 711
             +K
Sbjct: 1242 SDK 1244



 Score = 50.8 bits (120), Expect = 5e-06
 Identities = 58/266 (21%), Positives = 108/266 (40%), Gaps = 47/266 (17%)

Query: 275  VNQENERLMEE---YERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHK 331
            ++ E ++LM+E   +  L S+ LE + R    L+  T EKT      +  D R       
Sbjct: 1332 IDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLR------- 1384

Query: 332  PPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLE------------ 379
               +Q    L    + ++ +LR  +    + S  +M++ +     ++             
Sbjct: 1385 ---LQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQ 1441

Query: 380  ---QAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTH-----------ET-WAYGKEQIL 424
                 E+G +  L  E R L+ LE L  + +Q  S+            ET W   +  + 
Sbjct: 1442 VPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLA 1501

Query: 425  LQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQ 484
               DY   +L  V+  ++K++  ++++  H  RVE +    Q+L E    D  ++ +R  
Sbjct: 1502 QSADY-GTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLG 1560

Query: 485  KICDQWDRLGTLTQKRREALERMEKL 510
             +   WDRL      R  A  R+++L
Sbjct: 1561 HLQSSWDRL------REAAAGRLQRL 1580



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 42/237 (17%), Positives = 100/237 (42%), Gaps = 11/237 (4%)

Query: 508 EKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKAT-LP 566
           EK++E       +++  A+    W+E  +  L      +S+  +Q  + A   ++    P
Sbjct: 301 EKMIE-------KYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKP 353

Query: 567 EADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQ 626
               E+ ++  +   ++  +++ N ++ +  P+    + ++   W+ +++    R+ +L+
Sbjct: 354 PKFQEKGNLEVLLFTIQSRMRANNQKVYT--PHDGKLVSDINRAWESLEEAEYRRELALR 411

Query: 627 EELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQI-TGALEDQMNQLKQYEHNI 685
            EL RQ   E+L R+F  +A     W+      +A+ +      A+E    + +  E + 
Sbjct: 412 NELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDT 471

Query: 686 INYKNNIDKLEGDHQLIQEALVFDNKHTNYTMEHIRVGWELLLTTIARTINEVETQI 742
             Y+  +  LE   Q +++    D K      ++I   W  L   +      +ET +
Sbjct: 472 AAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTL 528



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 37/195 (18%), Positives = 81/195 (41%), Gaps = 21/195 (10%)

Query: 370  DIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDY 429
            +++ AWQ L  A  G          R  +L   A+KFR  +   +  ++  E I+ Q + 
Sbjct: 1880 EVSAAWQALLDACAG----------RRTQLVDTADKFRFFSMARDLLSW-MESIIRQIET 1928

Query: 430  ESA--SLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKIC 487
            +     ++ V  L++ H+   +++            + + L +  +  +  + ++ Q++ 
Sbjct: 1929 QERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVM 1988

Query: 488  DQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHS 547
                R   + +K     ER+  LLE       +F++ A+    W+      L      H+
Sbjct: 1989 S---RRKEMNEKWEARWERLRMLLEVC-----QFSRDASVAEAWLIAQEPYLASGDFGHT 2040

Query: 548  IEEIQSLITAHEQFK 562
            ++ ++ LI  HE F+
Sbjct: 2041 VDSVEKLIKRHEAFE 2055



 Score = 40.0 bits (92), Expect = 0.010
 Identities = 50/218 (22%), Positives = 93/218 (42%), Gaps = 33/218 (15%)

Query: 255  AFAGAEQAETAANRICKVLAVNQ--------ENERLMEEYER-----LASELLEWIRRTI 301
            A+AG E+AE   N+  +V A  Q           +L++  ++     +A +LL W+   I
Sbjct: 1865 AYAG-EKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESII 1923

Query: 302  PWLENRTPEKTMQAMQKKLEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFM 361
              +E +   + + +++  ++  +    + +         LE+  + LQ + + S      
Sbjct: 1924 RQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEE---- 1979

Query: 362  PSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAE--KFRQKASTHETWAYG 419
                K+   ++   +R E  EK    W        ERL  L E  +F + AS  E W   
Sbjct: 1980 -IREKLQQVMS---RRKEMNEKWEARW--------ERLRMLLEVCQFSRDASVAEAWLIA 2027

Query: 420  KEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDR 457
            +E  L   D+   ++  V  L+++HEAFE   A+  +R
Sbjct: 2028 QEPYLASGDF-GHTVDSVEKLIKRHEAFEKSTASWAER 2064



 Score = 36.6 bits (83), Expect = 0.11
 Identities = 31/135 (22%), Positives = 56/135 (41%), Gaps = 11/135 (8%)

Query: 404  EKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAA 463
            + F Q       W    +++L  +D        +     KH+AF ++LA+H+  +E I A
Sbjct: 1277 QNFLQNCQELTLWI--NDKLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDA 1334

Query: 464  IAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAK 523
              ++L +        V+ + + +   WD L   T+++ + L            L L+   
Sbjct: 1335 EGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARS-----SDLRLQ--- 1386

Query: 524  RAAPFNNWMEGAMED 538
              A  N W+  AMED
Sbjct: 1387 THADLNKWI-SAMED 1400


>gi|67782319 spectrin beta isoform b [Homo sapiens]
          Length = 2137

 Score =  416 bits (1070), Expect = e-116
 Identities = 252/653 (38%), Positives = 367/653 (56%), Gaps = 38/653 (5%)

Query: 15  DEDEYMIQEEEWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLML 74
           D D    +  E  R   L    E  Q+KTFT W NSHL +   +I ++ +D R+G  L+ 
Sbjct: 31  DNDNSSARLFERSRIKALADEREVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIK 90

Query: 75  LLEVISGERLPKPDRGKMRFHKIANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTLGMI 134
           LLEV+SGE LPKP +GKMR H + NV+KAL ++  + V L ++G+ +IVDGN ++ LG+I
Sbjct: 91  LLEVLSGEMLPKPTKGKMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLI 150

Query: 135 WTIILRFAIQDISV------EETSAKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCA 188
           WTIILRF IQDI V      E  SAK+ LLLWCQ KTA Y +VN+ NF +SWKDGL   A
Sbjct: 151 WTIILRFQIQDIVVQTQEGRETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNA 210

Query: 189 LIHRHRPDLIDYSKLNKDDPIGNINLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTY 248
           LIH+HRPDLID+ KL   +   N+  A  +AE+ L I  +LD ED+  T  PDE++I+TY
Sbjct: 211 LIHKHRPDLIDFDKLKDSNARHNLEHAFNVAERQLGIIPLLDPEDVF-TENPDEKSIITY 269

Query: 249 VSCFYHAFAGAEQAETAANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRT 308
           V  FYH F+  +       R+ KV+    E E+++E+Y  LAS+LL WI +TI  L +R 
Sbjct: 270 VVAFYHYFSKMKVLAVEGKRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRK 329

Query: 309 PEKTMQAMQKKLEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMV 368
              ++  +Q++L+ F  YR   KPPK QEK  LE+   T+Q+++R +N+  + P +GK+V
Sbjct: 330 FANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLV 389

Query: 369 SDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKD 428
           SDI  AW+ LE+AE   E  L NE+ R E+LE LA +F +KA+  ETW   + Q L+ +D
Sbjct: 390 SDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETW-LSENQRLVAQD 448

Query: 429 YESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICD 488
                L  V A  +KHEA E+D AA+++RV  +  +AQEL + +YHD   +  R   I  
Sbjct: 449 NFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILR 508

Query: 489 QWDRLGTLTQKRREALE---RMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIV 545
            W  L  L Q RR+ LE    ++KL +  D LH           +WM+     L      
Sbjct: 509 LWSYLQELLQSRRQRLETTLALQKLFQ--DMLH---------SIDWMDEIKAHLLSAEFG 557

Query: 546 HSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMD 605
             + E++ L+  H+     L EAD      +AIQ +  K I +  ++ +    Y      
Sbjct: 558 KHLLEVEDLLQKHK-----LMEAD------IAIQGDKVKAITAATLKFTEGKGYQPCDPQ 606

Query: 606 ELRTKWDKVKQLVPIRDQSLQEELARQHANERLRR--QFAAQANAIGPWIQNK 656
            ++   D++  L    ++       R+   E+ +R  +F  + +    WI+ K
Sbjct: 607 VIQ---DRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEK 656



 Score = 71.6 bits (174), Expect = 3e-12
 Identities = 98/459 (21%), Positives = 179/459 (38%), Gaps = 44/459 (9%)

Query: 292 ELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHKPPKVQEKCQLEINFNTLQTK 351
           +L + +  +I W++            K L +  D  +KHK  +     Q +         
Sbjct: 532 KLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAAT 591

Query: 352 LRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAE--KFRQK 409
           L+ +    + P + +++ D      R+   E+ +EE       R  +LE      KF  +
Sbjct: 592 LKFTEGKGYQPCDPQVIQD------RISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWE 645

Query: 410 ASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELN 469
               E+W   KEQI    DY    LT V  L RKH+AFE +L      +EQI   A  + 
Sbjct: 646 MDEAESWIKEKEQIYSSLDY-GKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMV 704

Query: 470 ELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFN 529
                    +  R +++  QWD+L  L    ++ L+  E           +F   A    
Sbjct: 705 ARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENF--------FQFQGDADDLK 756

Query: 530 NWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSY 589
            W++ A   L    +       ++L   H+ F   L E+ G       +   +E+  Q +
Sbjct: 757 AWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRG-------VMEHLEQQAQGF 809

Query: 590 NIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAI 649
                 S P  T  +  LR  + +V     +R Q LQE L        L   F  + +A 
Sbjct: 810 PEEFRDS-PDVTHRLQALRELYQQVVAQADLRQQRLQEAL-------DLYTVF-GETDAC 860

Query: 650 GPWIQNKMEEIARSSIQITGALEDQMNQLKQYEHNIIN--YKNNIDKLEGDHQLIQEALV 707
             W+  K + +A   +++   LED   ++ Q+  +I++   K  + +++G + L   +LV
Sbjct: 861 ELWMGEKEKWLA--EMEMPDTLEDL--EVVQHRFDILDQEMKTLMTQIDGVN-LAANSLV 915

Query: 708 FD----NKHTNYTMEHIRVGWELLLTTIARTINEVETQI 742
                 ++      +H+   W+   T ++     V++ +
Sbjct: 916 ESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSAL 954



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 62/303 (20%), Positives = 129/303 (42%), Gaps = 34/303 (11%)

Query: 416  WAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHD 475
            W   K +++         L  + A+ RK    E D+AA Q RV+ +   +Q+L +     
Sbjct: 969  WITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQ 1028

Query: 476  AVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGA 535
              ++  R + + + W  L       +++L+  E LL  + QL   F +    F  W+   
Sbjct: 1029 KEDIGQRQKHLEELWQGL-------QQSLQGQEDLLGEVSQLQ-AFLQDLDDFQAWLSIT 1080

Query: 536  MEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISS 595
             + +    +  S+ E + L+  H   K    E DG + S   ++   EKVIQ        
Sbjct: 1081 QKAVASEDMPESLPEAEQLLQQHAGIK---DEIDGHQDSYQRVKESGEKVIQ------GQ 1131

Query: 596  SNPYSTV---TMDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPW 652
            ++P   +    ++ L T W+ + ++   R  +L + L  Q   +  ++  A  +N     
Sbjct: 1132 TDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSN----- 1186

Query: 653  IQNKMEEIARSSIQITGALEDQMNQLKQYEHNIINYKNNIDK----LEGDHQLIQEALVF 708
                 +E   + ++   +LE     ++++E  + + +NN DK    ++  ++L+ E  ++
Sbjct: 1187 -----QEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLY 1241

Query: 709  DNK 711
             +K
Sbjct: 1242 SDK 1244



 Score = 50.8 bits (120), Expect = 5e-06
 Identities = 58/266 (21%), Positives = 108/266 (40%), Gaps = 47/266 (17%)

Query: 275  VNQENERLMEE---YERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHK 331
            ++ E ++LM+E   +  L S+ LE + R    L+  T EKT      +  D R       
Sbjct: 1332 IDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLR------- 1384

Query: 332  PPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLE------------ 379
               +Q    L    + ++ +LR  +    + S  +M++ +     ++             
Sbjct: 1385 ---LQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQ 1441

Query: 380  ---QAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTH-----------ET-WAYGKEQIL 424
                 E+G +  L  E R L+ LE L  + +Q  S+            ET W   +  + 
Sbjct: 1442 VPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLA 1501

Query: 425  LQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQ 484
               DY   +L  V+  ++K++  ++++  H  RVE +    Q+L E    D  ++ +R  
Sbjct: 1502 QSADY-GTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLG 1560

Query: 485  KICDQWDRLGTLTQKRREALERMEKL 510
             +   WDRL      R  A  R+++L
Sbjct: 1561 HLQSSWDRL------REAAAGRLQRL 1580



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 42/237 (17%), Positives = 100/237 (42%), Gaps = 11/237 (4%)

Query: 508 EKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKAT-LP 566
           EK++E       +++  A+    W+E  +  L      +S+  +Q  + A   ++    P
Sbjct: 301 EKMIE-------KYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKP 353

Query: 567 EADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQ 626
               E+ ++  +   ++  +++ N ++ +  P+    + ++   W+ +++    R+ +L+
Sbjct: 354 PKFQEKGNLEVLLFTIQSRMRANNQKVYT--PHDGKLVSDINRAWESLEEAEYRRELALR 411

Query: 627 EELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQI-TGALEDQMNQLKQYEHNI 685
            EL RQ   E+L R+F  +A     W+      +A+ +      A+E    + +  E + 
Sbjct: 412 NELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDT 471

Query: 686 INYKNNIDKLEGDHQLIQEALVFDNKHTNYTMEHIRVGWELLLTTIARTINEVETQI 742
             Y+  +  LE   Q +++    D K      ++I   W  L   +      +ET +
Sbjct: 472 AAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTL 528



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 37/195 (18%), Positives = 81/195 (41%), Gaps = 21/195 (10%)

Query: 370  DIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDY 429
            +++ AWQ L  A  G          R  +L   A+KFR  +   +  ++  E I+ Q + 
Sbjct: 1880 EVSAAWQALLDACAG----------RRTQLVDTADKFRFFSMARDLLSW-MESIIRQIET 1928

Query: 430  ESA--SLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKIC 487
            +     ++ V  L++ H+   +++            + + L +  +  +  + ++ Q++ 
Sbjct: 1929 QERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVM 1988

Query: 488  DQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHS 547
                R   + +K     ER+  LLE       +F++ A+    W+      L      H+
Sbjct: 1989 S---RRKEMNEKWEARWERLRMLLEVC-----QFSRDASVAEAWLIAQEPYLASGDFGHT 2040

Query: 548  IEEIQSLITAHEQFK 562
            ++ ++ LI  HE F+
Sbjct: 2041 VDSVEKLIKRHEAFE 2055



 Score = 40.0 bits (92), Expect = 0.010
 Identities = 50/218 (22%), Positives = 93/218 (42%), Gaps = 33/218 (15%)

Query: 255  AFAGAEQAETAANRICKVLAVNQ--------ENERLMEEYER-----LASELLEWIRRTI 301
            A+AG E+AE   N+  +V A  Q           +L++  ++     +A +LL W+   I
Sbjct: 1865 AYAG-EKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESII 1923

Query: 302  PWLENRTPEKTMQAMQKKLEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFM 361
              +E +   + + +++  ++  +    + +         LE+  + LQ + + S      
Sbjct: 1924 RQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEE---- 1979

Query: 362  PSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAE--KFRQKASTHETWAYG 419
                K+   ++   +R E  EK    W        ERL  L E  +F + AS  E W   
Sbjct: 1980 -IREKLQQVMS---RRKEMNEKWEARW--------ERLRMLLEVCQFSRDASVAEAWLIA 2027

Query: 420  KEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDR 457
            +E  L   D+   ++  V  L+++HEAFE   A+  +R
Sbjct: 2028 QEPYLASGDF-GHTVDSVEKLIKRHEAFEKSTASWAER 2064



 Score = 36.6 bits (83), Expect = 0.11
 Identities = 31/135 (22%), Positives = 56/135 (41%), Gaps = 11/135 (8%)

Query: 404  EKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAA 463
            + F Q       W    +++L  +D        +     KH+AF ++LA+H+  +E I A
Sbjct: 1277 QNFLQNCQELTLWI--NDKLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDA 1334

Query: 464  IAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAK 523
              ++L +        V+ + + +   WD L   T+++ + L            L L+   
Sbjct: 1335 EGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARS-----SDLRLQ--- 1386

Query: 524  RAAPFNNWMEGAMED 538
              A  N W+  AMED
Sbjct: 1387 THADLNKWI-SAMED 1400


>gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1
           [Homo sapiens]
          Length = 2564

 Score =  398 bits (1022), Expect = e-110
 Identities = 241/614 (39%), Positives = 341/614 (55%), Gaps = 31/614 (5%)

Query: 37  EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPKPDRGKMRFHK 96
           E  Q+KTFT W NSHL + G  I ++  D R+G  L  LLEV+SGE+LP+P RG+MR H 
Sbjct: 60  EAVQKKTFTKWVNSHLARVGCHIGDLYVDLRDGFVLTRLLEVLSGEQLPRPTRGRMRIHS 119

Query: 97  IANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVE-----ET 151
           + NV+KAL ++  + V L ++G+ +IVDGN ++TLG++WTIILRF IQ I +E     ET
Sbjct: 120 LENVDKALQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWTIILRFQIQVIKIETEDNRET 179

Query: 152 -SAKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPDLIDYSKLNKDDPIG 210
            SAK+ LLLWCQ KTA Y  VNIQNF TSW+DGL   ALIHRHRPDL+D+SKL K +   
Sbjct: 180 RSAKDALLLWCQMKTAGYPEVNIQNFTTSWRDGLAFNALIHRHRPDLVDFSKLTKSNANY 239

Query: 211 NINLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQAETAANRIC 270
           N+  A   AE+HL + ++LD ED VN   PDE++I+TYV  FYH F+  +       RI 
Sbjct: 240 NLQRAFRTAEQHLGLARLLDPED-VNMEAPDEKSIITYVVSFYHYFSKMKALAVEGKRIG 298

Query: 271 KVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKH 330
           KVL    E  +++E YE LA+ELL WI RT+  + N+    ++  +Q++L+ F  Y    
Sbjct: 299 KVLDQVLEVGKIIERYEELAAELLAWIHRTVGLISNQKFANSLSGVQQQLQAFTAYCTLE 358

Query: 331 KPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLL 390
           KP K QEK  LE+   ++Q+KLR  NR  F+P EG  + DI  AW  LE+AE   E  L 
Sbjct: 359 KPVKFQEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHEREAALR 418

Query: 391 NEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESD 450
            E+ R E+LE LA++F  K +  E+W   + Q L+ +D     L  V A ++KHEA E+D
Sbjct: 419 AELIRQEKLELLAQRFDHKVAMRESW-LNENQRLVSQDNFGYELPAVEAAMKKHEAIEAD 477

Query: 451 LAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKL 510
           +AA+++RV+ +A +AQ L    Y+D   V  +   +  QW  L  L   RR  LE+   L
Sbjct: 478 IAAYEERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQWALLTGLVGARRTRLEQNLAL 537

Query: 511 LETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADG 570
            +   ++            +WME     L        + E   L+  H           G
Sbjct: 538 QKVFQEM--------VYMVDWMEEMQAQLLSRECGQHLVEADDLLQKH-----------G 578

Query: 571 ERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQEELA 630
             +  +A Q+E  + + +  +R S    Y       +  + + V   +      LQE+ A
Sbjct: 579 LLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCL----AELQEQAA 634

Query: 631 RQHANERLRRQFAA 644
           R+ A     R   A
Sbjct: 635 RRRAELEASRSLWA 648



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 88/484 (18%), Positives = 200/484 (41%), Gaps = 56/484 (11%)

Query: 260  EQAETAANRICKVLAVNQENERLM---EEYERLASEL---LEWIRRTIPWLENRTPEKTM 313
            E+      R+ ++L   QE  RL+   +E  ++A +L   L W++  +P          +
Sbjct: 1488 ERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGL 1547

Query: 314  QAMQKKLEDFRDYRRKHKP--PKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDI 371
            QA+Q+ ++  +  RR+ +   P+++E  +      +L++    + R        + +  +
Sbjct: 1548 QAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVR--------RGLEQL 1599

Query: 372  AGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYES 431
              AW  L +A +  ++ L    +         E++    +  E W  G++++L+  + + 
Sbjct: 1600 QSAWAGLREAAERRQQVLDAAFQ--------VEQYYFDVAEVEAWL-GEQELLMMSEDKG 1650

Query: 432  ASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWD 491
                    LL+KH   E  +  +++ + Q++   + L E+ + D+  ++ R  ++   + 
Sbjct: 1651 KDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYV 1710

Query: 492  RLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEI 551
             L  L ++RR ALE+   L         + +++ +   +W+           +    E +
Sbjct: 1711 ALKELGEERRVALEQQYWL--------YQLSRQVSELEHWIAEKEVVAGSPELGQDFEHV 1762

Query: 552  QSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKW 611
              L     +F +    A  ER  + A+   V+++I+  +   ++   +     D L   W
Sbjct: 1763 SVLQEKFSEFASETGMAGRER--LAAVNQMVDELIECGHTAAATMAEWK----DGLNEAW 1816

Query: 612  DKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSI--QITG 669
             ++ +L+  R Q L        A  R   +F + A  +   I+ K   + R +   +   
Sbjct: 1817 AELLELMGTRAQLL--------AASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRP 1868

Query: 670  ALEDQMNQLKQYEHNIINYKNNIDKL-EGDHQLIQEALVFDNKHTNYTM---EHIRVGWE 725
            +       L+ +EH++    + + +L EG  QL     V+  +H        + +  GW+
Sbjct: 1869 SASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQL---RTVYAGEHAEAIASREQEVLQGWK 1925

Query: 726  LLLT 729
             LL+
Sbjct: 1926 ELLS 1929



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 73/329 (22%), Positives = 134/329 (40%), Gaps = 27/329 (8%)

Query: 257  AGAEQAETAANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAM 316
            A AE  E    R  ++LA ++E  +   +   L  ++ E  RR         P  +  +M
Sbjct: 1815 AWAELLELMGTR-AQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSM 1873

Query: 317  QKKLEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQ 376
            Q+ L  F    +      V +  QL+     L+T     +  A    E     ++   W+
Sbjct: 1874 QRTLRAFEHDLQL----LVSQVRQLQEGAAQLRTVYAGEHAEAIASRE----QEVLQGWK 1925

Query: 377  RLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTE 436
             L  A    E+  L+     + L     +F  +     +W  G    +   D +   ++ 
Sbjct: 1926 ELLSA---CEDARLHVSSTADAL-----RFHSQVRDLLSWMDGIASQIGAAD-KPRDVSS 1976

Query: 437  VRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTL 496
            V  L+  H+  +++L A   RV ++        EL     +N +    +I  Q D+LGT 
Sbjct: 1977 VEVLMNYHQGLKTELEA---RVPELTTC----QELGRSLLLNKSAMADEIQAQLDKLGTR 2029

Query: 497  TQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLIT 556
             ++  E  +R  + L+ + ++H +FA+ A   + W+      LQ   +  S++E++ LI 
Sbjct: 2030 KEEVSEKWDRHWEWLQQMLEVH-QFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIR 2088

Query: 557  AHEQFKATLPEADGERQSIMAIQNEVEKV 585
             HE F+     A  ER S +     +EK+
Sbjct: 2089 RHEAFRKA-AAAWEERFSSLRRLTTIEKI 2116



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 74/354 (20%), Positives = 149/354 (42%), Gaps = 41/354 (11%)

Query: 335  VQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIR 394
            V+E  +   +F T     +   + A   +EG +        Q  E   +  E+   N++R
Sbjct: 1234 VEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLR 1293

Query: 395  RLERLEHLAEKFRQK---ASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDL 451
              + ++ L ++   +      HE   +  E++L+ +D       ++     +H+AF ++L
Sbjct: 1294 AQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTREDNHKLHKRWLRHQAFMAEL 1353

Query: 452  AAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLL 511
            A +++ +E+I    Q+L +     A +V  +  +I   W  L + TQ +   L    K  
Sbjct: 1354 AQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASK-- 1411

Query: 512  ETIDQLHLEFAKRAAPFNNWMEGAMEDLQ---DMFIVHS-IEEIQSLITAHEQF------ 561
               DQL   FA+      + ME  ++D+    D+  V+S ++++QS+ +  E++      
Sbjct: 1412 --ADQLVQSFAELDKKLLH-MESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGE 1468

Query: 562  ----KATLP------EADGERQSIMA--IQNEVEKVIQSYNIRISSSNPYSTVTMDELRT 609
                 A LP      E  GERQ+ +   +   +E + +   + ++S   +      +   
Sbjct: 1469 LQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDEL 1528

Query: 610  KWDKVKQLVPI-----RDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKME 658
             W  V++ +P+     R   LQ        N+ LRR+  A     GP ++  +E
Sbjct: 1529 AW--VQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAH----GPRLEEVLE 1576



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 68/339 (20%), Positives = 134/339 (39%), Gaps = 34/339 (10%)

Query: 370  DIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDY 429
            ++   W  L  A +   E  +    RL+R  H  + F       +  A G E  L     
Sbjct: 1065 ELGAEWGALASAAQACGE-AVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPN--- 1120

Query: 430  ESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHD---AVNVNDRCQKI 486
               SL E  ALL +H A + ++   ++   +I A ++ L   D  +    + +++    +
Sbjct: 1121 ---SLEEADALLARHAALKEEVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPHL 1177

Query: 487  CDQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVH 546
               W +L  L + RREAL +       I QL L   ++A       E A+   +   +  
Sbjct: 1178 ELGWHKLLGLWEARREALVQAH-----IYQLFLRDLRQALVVLRNQEMALSGAE---LPG 1229

Query: 547  SIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDE 606
            ++E ++  +  H  F  T+   +  +Q +       E +++  NI    +    T  +++
Sbjct: 1230 TVESVEEALKQHRDFLTTM---ELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLLEK 1286

Query: 607  LRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQ 666
             +    + +Q +    Q L ++L  QH        F    + +  WI  KM      + +
Sbjct: 1287 NQENQLRAQQWM----QKLHDQLELQH--------FLRDCHELDGWIHEKMLMARDGTRE 1334

Query: 667  ITGALEDQMNQLKQYEHNIINYKNNIDKLEGD-HQLIQE 704
                L  +  + + +   +   K  ++K+E +  QL+QE
Sbjct: 1335 DNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQE 1373



 Score = 37.0 bits (84), Expect = 0.082
 Identities = 33/132 (25%), Positives = 59/132 (44%), Gaps = 7/132 (5%)

Query: 377 RLEQAEKGYEEWLLNEIRRLER--LEHLAEKFRQKASTH--ETWAYGKEQILLQKDYESA 432
           R+ +AE+ + E  + E+  L R  L      +R     H  E W   KEQ LL       
Sbjct: 855 RVVEAEQLFAE--VTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLSMRVPD- 911

Query: 433 SLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDR 492
           SL +V  +  + E+ + ++ +   RV  +    QEL E  +  +  V      +  +W+R
Sbjct: 912 SLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLNSRWNR 971

Query: 493 LGTLTQKRREAL 504
           +  L ++R+E +
Sbjct: 972 IVELVEQRKEEM 983


>gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens]
          Length = 3639

 Score =  346 bits (887), Expect = 6e-95
 Identities = 203/553 (36%), Positives = 310/553 (56%), Gaps = 22/553 (3%)

Query: 38  KQQRKTFTAWCNSHLR--KAGTQIENIEEDFRNGLKLMLLLEVISGERLPKPDRGKMRFH 95
           + Q KTFT W N+  +  +AG +I N+  +  +G+ L+ LLE+ISGE LP P RG++R H
Sbjct: 19  QMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISGEALPPPSRGRLRVH 78

Query: 96  KIANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEET---- 151
            + N ++AL ++ +K V +  IG E IVDG+  + LG+IW IILRF I  IS+++     
Sbjct: 79  FLENSSRALAFLRAK-VPVPLIGPENIVDGDQTLILGLIWVIILRFQISHISLDKEEFGA 137

Query: 152 -----SAKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPDLIDYSKLNKD 206
                S KE LL+WCQRKTA Y NVNI +F  SW DGLG  ALIH HRPDL+DY  L  D
Sbjct: 138 SAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHAHRPDLLDYGSLRPD 197

Query: 207 DPIGNINLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQAETAA 266
            P+ N+  A  +AE+ L I ++LD ED+    +PDER+IMTYVS +YH  +   Q +T  
Sbjct: 198 RPLHNLAFAFLVAEQELGIAQLLDPEDVA-AAQPDERSIMTYVSLYYHYCSRLHQGQTVQ 256

Query: 267 NRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDY 326
            R+ K+L   QE E L  +YE+L ++LL WI      LE R    ++ AM++ L  F  +
Sbjct: 257 RRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIF 316

Query: 327 RRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYE 386
           R + KPP++Q++   E     LQT L+  NR  F+P EG  +++++  W  LE AE    
Sbjct: 317 RTQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCWAGLEWAEAARS 376

Query: 387 EWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEA 446
           + L   + +L+RLE LA +F+ KA+  E++    EQ+L Q     ASL  V A +++   
Sbjct: 377 QALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGM 436

Query: 447 FESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALER 506
            E+ +   + R + +A IA  L +  YH   +V  R +++  +W RL    Q +R+ +  
Sbjct: 437 LEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVAD 496

Query: 507 MEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLP 566
           M+ +L  + ++           ++ +E   E  +       + E+  L+  H+  +A + 
Sbjct: 497 MQAVLSLLQEVEAA--------SHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQV- 547

Query: 567 EADGERQSIMAIQ 579
            A G   S +A Q
Sbjct: 548 SAHGAHVSHLAQQ 560



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 70/305 (22%), Positives = 125/305 (40%), Gaps = 24/305 (7%)

Query: 336  QEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRR 395
            Q + +  ++    Q +  +    AF+     +  D+    +RL Q  K   E  L E R 
Sbjct: 2794 QRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLRE-PLQERRT 2852

Query: 396  LERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQ 455
                  L  KF + A     W   K  +   +DY   SL+ VR L  +H+  ES++++H+
Sbjct: 2853 ALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDY-GQSLSAVRHLQEQHQNLESEMSSHE 2911

Query: 456  DRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETID 515
                 +     +L +  +  A  V  R Q++      L     +RR  L++ ++  + + 
Sbjct: 2912 ALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLT 2971

Query: 516  QLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSI 575
            +L LE     A       G + D +DM   HS E  Q+L          L   +  ++ +
Sbjct: 2972 EL-LEAGSWLAE-----RGHVLDSEDM--GHSAEATQAL----------LRRLEATKRDL 3013

Query: 576  MAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLV---PIRDQSLQEELARQ 632
             A    +E++ Q+  +  S  NP S   + +L+   +   +L+     R   LQE+L + 
Sbjct: 3014 EAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQL-QL 3072

Query: 633  HANER 637
            H  ER
Sbjct: 3073 HQLER 3077



 Score = 53.9 bits (128), Expect = 6e-07
 Identities = 65/280 (23%), Positives = 120/280 (42%), Gaps = 36/280 (12%)

Query: 379  EQAEKGYEEWLLNEIRRLERL--EHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTE 436
            +Q ++ Y+ W     R+ ERL  E   + F ++    E      +++ L+     +S+ E
Sbjct: 1994 DQRDQVYQTWA----RKQERLQAEQQEQLFLRECGRLEE-ILAAQEVSLKTSALGSSVEE 2048

Query: 437  VRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTL 496
            V  L+RKHE F   L A QD+ E  AA+ + L  L       V DR   +  +  R+  L
Sbjct: 2049 VEQLIRKHEVFLKVLTA-QDKKE--AALRERLKTL---RRPRVRDRLPILLQRRMRVKEL 2102

Query: 497  TQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLIT 556
             + R  AL            L   F + A    +W++   + L++      + +    + 
Sbjct: 2103 AESRGHALH--------ASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLL 2154

Query: 557  AHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQ 616
             H+ F+A   E     + + ++  + E ++   + R    +      +  LR  W+ ++Q
Sbjct: 2155 KHQAFEA---EVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQ----RLQGLRKHWEDLRQ 2207

Query: 617  LVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNK 656
             + +R Q L++   R++  E L+R   A+A     WIQ K
Sbjct: 2208 AMALRGQELED---RRNFLEFLQRVDLAEA-----WIQEK 2239



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 69/294 (23%), Positives = 116/294 (39%), Gaps = 55/294 (18%)

Query: 376  QRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLT 435
            Q L+   +  ++WL  E   L++     + F    + H+ W        L  D     + 
Sbjct: 1156 QELKVLWEQRQQWL-QEGLELQKFGREVDGFTATCANHQAW--------LHLDNLGEDVR 1206

Query: 436  EVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRL-G 494
            E  +LL++H  F   L+    R E + A  ++L +  +  A  V ++ Q I  QW RL G
Sbjct: 1207 EALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQG 1266

Query: 495  TLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSL 554
               Q+RR+ L  ++                      W +   E +Q M       E + L
Sbjct: 1267 RSEQRRRQLLASLQ-------------------LQEWKQDVAELMQWM-------EEKGL 1300

Query: 555  ITAHEQFKA------TLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYS----TVTM 604
            + AHE   A      TL   +     ++A +  VE  +Q     + S  P         +
Sbjct: 1301 MAAHEPSGARRNILQTLKRHEAAESELLATRRHVE-ALQQVGRELLSRRPCGQEDIQTRL 1359

Query: 605  DELRTKWDKVKQLVPIRDQSL-----QEELAR--QHANERLRR-QFAAQANAIG 650
              LR+KW+ + + +  R   L     QE+L R  Q A E+L + + A Q++  G
Sbjct: 1360 QGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETG 1413



 Score = 50.4 bits (119), Expect = 7e-06
 Identities = 54/232 (23%), Positives = 98/232 (42%), Gaps = 33/232 (14%)

Query: 292  ELLEWIRRTIPWLENRTPEKTMQAMQKKLED-------FRDYRRKHKPPKVQEKCQLEIN 344
            E L+ +     W++ +  +  +  + + LE         R++R       V + C   I+
Sbjct: 2224 EFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSIS 2283

Query: 345  FNTLQTKLRISNRPAFMPSEGKMV----SDIAGAWQRLEQAEKGYEEWLLN--EIRRLER 398
              +LQ K R        P E K++    S +   W         Y++ L    EI  L R
Sbjct: 2284 DLSLQLKNRD-------PEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSR 2336

Query: 399  -LEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDR 457
             L+++ ++ ++K +  +    GK+            L  V+ LLRKHE  E ++   Q +
Sbjct: 2337 ELDNVTKRIQEKEALIQALDCGKD------------LESVQRLLRKHEELEREVHPIQAQ 2384

Query: 458  VEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEK 509
            VE +      L +     A  +  R Q++ + W +L +  QKRREAL+ + +
Sbjct: 2385 VESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQ 2436



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 78/400 (19%), Positives = 163/400 (40%), Gaps = 56/400 (14%)

Query: 341  LEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLE 400
            LE   + LQ+ +     P +  S+      + G  + L+   K  +E +    RR    +
Sbjct: 1013 LERRVHFLQSVVVKVEEPGYAESQ-----PLQGQVETLQGLLKQVQEQVAQRARRQAETQ 1067

Query: 401  HLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQ 460
               + F Q++     WA   +  L  K+  S  +   + LLR+H+    ++   Q+R++Q
Sbjct: 1068 -ARQSFLQESQQLLLWAESVQAQLRSKEV-SVDVASAQRLLREHQDLLEEIHLWQERLQQ 1125

Query: 461  IAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALE---RMEKLLETIDQL 517
            + A +Q +  LD  D+  V +  + +  Q   L  L ++R++ L+    ++K    +D  
Sbjct: 1126 LDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVD-- 1183

Query: 518  HLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIMA 577
               F    A    W+   +++L +      + E  SL+  H +F   L       +++ A
Sbjct: 1184 --GFTATCANHQAWLH--LDNLGE-----DVREALSLLQQHREFGRLLSTLGPRAEALRA 1234

Query: 578  IQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQEELAR-QHANE 636
                 EK++Q       S +P +    ++L               QS+Q +  R Q  +E
Sbjct: 1235 ---HGEKLVQ-------SQHPAAHTVREQL---------------QSIQAQWTRLQGRSE 1269

Query: 637  RLRRQFAAQANA------IGPWIQNKMEEIARSSIQITGALEDQMNQLKQY---EHNIIN 687
            + RRQ  A          +   +Q   E+   ++ + +GA  + +  LK++   E  ++ 
Sbjct: 1270 QRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELLA 1329

Query: 688  YKNNIDKLEGDHQLIQEALVFDNKHTNYTMEHIRVGWELL 727
             + +++ L+   + +        +     ++ +R  WE L
Sbjct: 1330 TRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEAL 1369



 Score = 47.8 bits (112), Expect = 5e-05
 Identities = 72/398 (18%), Positives = 146/398 (36%), Gaps = 38/398 (9%)

Query: 301  IPWLENRTPEKTMQAMQKKLEDFRDYRRKHKPPKVQEKCQLEINFNTLQT--KLRISNRP 358
            + W+    P  +  +  + L   +   RKHK  +V+ K         L +   L  S  P
Sbjct: 1498 LSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHP 1557

Query: 359  AFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAY 418
                   +   ++ G W  LE+A +   + L   +          +++    S  E W  
Sbjct: 1558 QAQHIV-EQCQELEGHWAELERACEARAQCLQQAV--------TFQQYFLDVSELEGWVE 1608

Query: 419  GKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVN 478
             K  ++  +DY       +R L+ KH+A + +LA +   +E++   AQ L   +  +   
Sbjct: 1609 EKRPLVSSRDYGRDEAATLR-LINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQR 1667

Query: 479  VNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMED 538
            V           +RL    +  +E     ++ LE   +LH EF + A     W+    + 
Sbjct: 1668 VVQ---------ERLREQLRALQELAATRDRELEGTLRLH-EFLREAEDLQGWLASQKQA 1717

Query: 539  LQ-DMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSN 597
             +    +    E    L T   +F+    + +   Q + A +   E +++    R  S+ 
Sbjct: 1718 AKGGESLGEDPEHALHLCTKFAKFQ---HQVEMGSQRVAACRLLAESLLE----RGHSAG 1770

Query: 598  PYSTVTMDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKM 657
            P       +L+T W ++ +L   R  +L++       +  L              +Q K 
Sbjct: 1771 PMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQ--------VQEKA 1822

Query: 658  EEIARSSIQITGALEDQMNQLKQYEHNIINYKNNIDKL 695
              +  +  +    LE Q+   +  E  ++  +  + +L
Sbjct: 1823 TSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQEL 1860



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 71/322 (22%), Positives = 130/322 (40%), Gaps = 36/322 (11%)

Query: 337  EKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYE-EWLLNEIRR 395
            ++C+ E++  T    L  S     + +     SDI      LEQ     E  W  ++++ 
Sbjct: 2478 QECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQL 2537

Query: 396  LERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQ 455
             + LE   + F       E W   KE  L  +      L  +  LL KH+  E DL    
Sbjct: 2538 QQALE--LQLFLSSVEKMERWLCSKEDSLASEGLWDP-LAPMEPLLWKHKMLEWDLEVQA 2594

Query: 456  DRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETID 515
             ++  + A A+ L++  + +A +   RCQ +  + + L      RR  LE + +L     
Sbjct: 2595 GKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQL----- 2649

Query: 516  QLHLEFAKRAAPFNNWM-EGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQS 574
            Q  L+ ++  A    W+ E  +  L++  +  ++  + + +   + F+A   E D     
Sbjct: 2650 QAFLQDSQEVAA---WLREKNLVALEEGLLDTAM--LPAQLQKQQNFQA---ELDASMHQ 2701

Query: 575  IMAIQNEVEKVIQSYNIRISSSNPYSTV---TMDELRTKWDKVKQLVPIRDQSLQEELAR 631
               +Q E ++++Q         +P S      ++EL   W +      ++D S ++    
Sbjct: 2702 QQELQREGQRLLQ-------GGHPASEAIQERLEELGALWGE------LQDNSQKKVAKL 2748

Query: 632  QHANE--RLRRQFAAQANAIGP 651
            Q A E  RLRR      N + P
Sbjct: 2749 QKACEALRLRRSMEELENWLEP 2770



 Score = 43.9 bits (102), Expect = 7e-04
 Identities = 61/273 (22%), Positives = 106/273 (38%), Gaps = 30/273 (10%)

Query: 369  SDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKD 428
            S I  AW+RL+QA K   E L           H    F+Q A+  E     +E+  L K 
Sbjct: 3153 SRIEAAWERLDQAIKARTENL--------AAAHEVHSFQQAAA--ELQGRMQEKTALMKG 3202

Query: 429  YESA-SLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKIC 487
             +   SL+ VR L ++H   E +L A +  V ++   A  L +L  H A        K+ 
Sbjct: 3203 EDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRLGQL--HPA--APGGLAKVQ 3258

Query: 488  DQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHS 547
            + W  L    Q+R + L +         Q H  F  R      W +   E      +   
Sbjct: 3259 EAWATLQAKAQERGQWLAQAA-------QGH-AFLGRCQELLAWAQERQELASSEELAED 3310

Query: 548  IEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDEL 607
            +   + L+  HE+    + E    R     ++ E ++++ + +   +      T  + EL
Sbjct: 3311 VAGAEQLLGQHEELGQEIREC---RLQAQDLRQEGQQLVDNSHFMSAE----VTECLQEL 3363

Query: 608  RTKWDKVKQLVPIRDQSLQEELARQHANERLRR 640
              +  ++++   +R Q   E    Q   +RL +
Sbjct: 3364 EGRLQELEEAWALRWQRCAESWGLQKLRQRLEQ 3396



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 36/131 (27%), Positives = 62/131 (47%), Gaps = 11/131 (8%)

Query: 338  KCQLEINFNTLQTKLRISNRPAFMPSE-GKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRL 396
            +C+L+   +  Q   ++ +   FM +E  + + ++ G  Q LE+A      W L   R  
Sbjct: 3330 ECRLQAQ-DLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEA------WALRWQRCA 3382

Query: 397  ERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQD 456
            E      +K RQ+    E W    E +LL+ DY   S+++V  LL +H+  E  LAA ++
Sbjct: 3383 ESWG--LQKLRQRLEQAEAWLACWEGLLLKPDY-GHSVSDVELLLHRHQDLEKLLAAQEE 3439

Query: 457  RVEQIAAIAQE 467
            +  Q+     E
Sbjct: 3440 KFAQMQKTEME 3450



 Score = 40.8 bits (94), Expect = 0.006
 Identities = 68/353 (19%), Positives = 148/353 (41%), Gaps = 65/353 (18%)

Query: 321  EDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQ 380
            +D R  +R  K  +     QLE    TL  K         M +   M   +A +   LE+
Sbjct: 1414 QDLRSSQRLQKRHQ-----QLESESRTLAAK---------MAALASMAHGMAASPAILEE 1459

Query: 381  AEKGYEEWLLNEIRRLERLE-HLAEKFRQKAST---HETWAYGKEQILLQKDY----ESA 432
             +K         +RRLE L+ HLA +  Q  ++   H+       ++    ++       
Sbjct: 1460 TQK--------HLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPT 1511

Query: 433  SLTE----VRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICD 488
            S TE     ++L RKH+  + ++ AHQ +V+++ +  + L    +  A ++ ++CQ++  
Sbjct: 1512 SYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEG 1571

Query: 489  QWDRLGTLTQKRREALERMEKLLE-TIDQLHLE-FAKRAAPFNNWMEGAMEDLQDMFIVH 546
             W  L    + R + L++     +  +D   LE + +   P  +  +   ++   + +++
Sbjct: 1572 HWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLIN 1631

Query: 547  SIEEIQSLITAHEQFKATLPEADGERQSIMAIQ-NEVEKVIQSYNIRISSSNPYSTVTMD 605
              + +Q  +     + +++ E D   Q++   +  E ++V+Q                 +
Sbjct: 1632 KHQALQEELAI---YWSSMEELDQTAQTLTGPEVPEQQRVVQ-----------------E 1671

Query: 606  ELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKME 658
             LR +   +++L   RD+ L+  L R H       +F  +A  +  W+ ++ +
Sbjct: 1672 RLREQLRALQELAATRDRELEGTL-RLH-------EFLREAEDLQGWLASQKQ 1716



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 62/334 (18%), Positives = 131/334 (39%), Gaps = 45/334 (13%)

Query: 370 DIAGAWQRLEQAEKGYEEWL------LNEIRRLERLEHLAEKFRQKASTHETWAYGKEQI 423
           ++   WQRL Q  +G  + +      L+ ++ +E   H  E+ ++ A    + A G++  
Sbjct: 475 EVTVRWQRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPA---RSTACGQQ-- 529

Query: 424 LLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRC 483
                     L EV  LL++H+  E+ ++AH   V  +A    EL+         +  + 
Sbjct: 530 ----------LAEVVELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKA 579

Query: 484 QKICDQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMF 543
           + +      L  L + RR  LE      +T+ +   EF +       W++   + + +  
Sbjct: 580 RTLAQLQQSLVALVRARRALLE------QTLQR--AEFLRNCEEEEAWLKECGQRVGNAA 631

Query: 544 IVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVT 603
           +   + +I   +  H+       EA+  R   + +  ++ +  +  + R   + P     
Sbjct: 632 LGRDLSQIAGALQKHKAL-----EAEVHRHQAVCV--DLVRRGRDLSARRPPTQPDPGER 684

Query: 604 MDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARS 663
            + ++  W  ++  V  R   LQ  L        L  Q+ A A     W++ +   + R+
Sbjct: 685 AEAVQGGWQLLQTRVVGRGARLQTAL--------LVLQYFADAAEAASWLRERRSSLERA 736

Query: 664 SI-QITGALEDQMNQLKQYEHNIINYKNNIDKLE 696
           S  Q   A E  + +  + E  +  +   + +LE
Sbjct: 737 SCGQDQAAAETLLRRHVRLERVLRAFAAELRRLE 770



 Score = 37.0 bits (84), Expect = 0.082
 Identities = 80/432 (18%), Positives = 159/432 (36%), Gaps = 56/432 (12%)

Query: 268  RICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYR 327
            R C+  A   +     ++Y    SEL  W+    P + +R   +   A  + +       
Sbjct: 1578 RACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLIN------ 1631

Query: 328  RKHKPPKVQEKCQLEINFNTL----QTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEK 383
             KH+   +QE  +L I ++++    QT   ++     +P + ++V +      RL +  +
Sbjct: 1632 -KHQA--LQE--ELAIYWSSMEELDQTAQTLTGPE--VPEQQRVVQE------RLREQLR 1678

Query: 384  GYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRK 443
              +E      R LE    L E F ++A   + W   ++Q     +           L  K
Sbjct: 1679 ALQELAATRDRELEGTLRLHE-FLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTK 1737

Query: 444  HEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREA 503
               F+  +     RV     +A+ L E  +     V  R Q +   W  L  LTQ R  A
Sbjct: 1738 FAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHA 1797

Query: 504  LERME-------KLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLIT 556
            L   E        LLE + Q+     K  +  NN             +   +  +++ + 
Sbjct: 1798 LRDTETTLRVHRDLLEVLTQVQ---EKATSLPNN-------------VARDLCGLEAQLR 1841

Query: 557  AHEQFKATLPEADGERQSIMAIQNEVEKV--------IQSYNIRISSSNPYSTVTMDELR 608
            +H+  +  L   + + Q ++     V+K+        +Q     ++ +       M++ R
Sbjct: 1842 SHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRR 1901

Query: 609  TKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQIT 668
             + ++ + L   R              + L+ + ++Q  + GP ++    +  R+ ++  
Sbjct: 1902 AQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGP-LKLSAHQWLRAELEAR 1960

Query: 669  GALEDQMNQLKQ 680
              L  Q  QL Q
Sbjct: 1961 EKLWQQATQLGQ 1972



 Score = 36.6 bits (83), Expect = 0.11
 Identities = 45/238 (18%), Positives = 95/238 (39%), Gaps = 8/238 (3%)

Query: 494 GTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQS 553
           G   Q+R   L ++   L+  + L  ++ +  A    W+      L+      S+  ++ 
Sbjct: 252 GQTVQRR---LTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQ 308

Query: 554 LITAHEQFKAT-LPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWD 612
           L+ A   F+    P    +R +  A+   ++  +Q+ N R     P+  + + EL   W 
Sbjct: 309 LLAAFTIFRTQEKPPRLQQRGAAEALLFRLQTALQAQNRR--PFLPHEGLGLAELSQCWA 366

Query: 613 KVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEI--ARSSIQITGA 670
            ++     R Q+LQ+ L +    E L R+F  +A     ++++  + +  AR+       
Sbjct: 367 GLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLAT 426

Query: 671 LEDQMNQLKQYEHNIINYKNNIDKLEGDHQLIQEALVFDNKHTNYTMEHIRVGWELLL 728
           +E  + +L   E  I+  +     L     ++++             E + V W+ LL
Sbjct: 427 VEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLL 484



 Score = 33.1 bits (74), Expect = 1.2
 Identities = 61/336 (18%), Positives = 134/336 (39%), Gaps = 37/336 (11%)

Query: 376  QRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHE--TWAYGKEQILLQKDYESAS 433
            +RLE+    + E   N  +++ +L+   E  R + S  E   W    E + L+      +
Sbjct: 2725 ERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIE-VELRAPTVGQA 2783

Query: 434  LTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRL 493
            L  V  LL      E+ +     + E +   AQ      +  A +V ++ +++  ++  L
Sbjct: 2784 LPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSL 2843

Query: 494  GTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQS 553
                Q+RR ALE    LL+       E A        W++  +          S+  ++ 
Sbjct: 2844 REPLQERRTALEARSLLLKFFRDADEEMA--------WVQEKLPLAAAQDYGQSLSAVRH 2895

Query: 554  LITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDK 613
            L   H+             +S M+    + +V+     ++  +  ++     E+  +  +
Sbjct: 2896 LQEQHQNL-----------ESEMSSHEALTRVVLGTGYKLVQAGHFAA---HEVAARVQQ 2941

Query: 614  V-KQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNK-----MEEIARSSIQI 667
            + K +  +R ++ +  L  Q A E   +QF  +    G W+  +      E++  S+ + 
Sbjct: 2942 LEKAMAHLRAEAARRRLLLQQAQE--AQQFLTELLEAGSWLAERGHVLDSEDMGHSA-EA 2998

Query: 668  TGALEDQMNQLKQYEHNIINYKNNIDKLEGDHQLIQ 703
            T AL   + +L+  + ++  +   I++L+    L++
Sbjct: 2999 TQAL---LRRLEATKRDLEAFSPRIERLQQTAALLE 3031



 Score = 31.2 bits (69), Expect = 4.5
 Identities = 42/197 (21%), Positives = 73/197 (37%), Gaps = 17/197 (8%)

Query: 261 QAETAANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKL 320
           +A T A     ++A+ +    L+E+  + A E L        WL+         A+ + L
Sbjct: 578 KARTLAQLQQSLVALVRARRALLEQTLQRA-EFLRNCEEEEAWLKECGQRVGNAALGRDL 636

Query: 321 EDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRIS-NRPAFMPSEGKMVSDIAGAWQRLE 379
                  +KHK  + +      +  + ++    +S  RP   P  G+    + G WQ L+
Sbjct: 637 SQIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQ 696

Query: 380 QAEKGYEEWLLNEIRRLERLEHLAEK---FRQKASTHETWAYGKEQILLQKDYESASLTE 436
               G    L   +  L+     AE     R++ S+ E  + G++Q              
Sbjct: 697 TRVVGRGARLQTALLVLQYFADAAEAASWLRERRSSLERASCGQDQ------------AA 744

Query: 437 VRALLRKHEAFESDLAA 453
              LLR+H   E  L A
Sbjct: 745 AETLLRRHVRLERVLRA 761


>gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
            isoform 2 [Homo sapiens]
          Length = 2472

 Score =  280 bits (717), Expect = 3e-75
 Identities = 165/499 (33%), Positives = 275/499 (55%), Gaps = 22/499 (4%)

Query: 405  KFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAA-HQDRVEQIAA 463
            +F  KA   E+W   KE  L   DY    L+ V+ LL K E F++ L A  Q+ +  I A
Sbjct: 1980 QFNWKADVVESWIGEKENSLKTDDY-GRDLSSVQTLLTKQETFDAGLQAFQQEGIANITA 2038

Query: 464  IAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAK 523
            +  +L    +  +  +  R   +  +W +L   +  R++ L   +     ++ L L FAK
Sbjct: 2039 LKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAK 2098

Query: 524  RAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVE 583
            +A+ FN+W E A EDL D    +S+EEI++L  AH+ F+++L  A  +   +     E++
Sbjct: 2099 KASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLA----ELD 2154

Query: 584  KVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFA 643
            + I+S+ +   +SNPY+  TM+ L   W  +++++  R+  LQ+E  RQ  N++LR++FA
Sbjct: 2155 RQIKSFRV---ASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFA 2211

Query: 644  AQANAIGPWIQNKMEEIARSSIQI--TGALEDQMNQLKQYEHNIINYKNNIDKLEGDHQL 701
              ANA   WIQ     +   S  +  +G LE Q+   K+    I   ++ + K+E     
Sbjct: 2212 QHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAA 2271

Query: 702  IQEALVFDNKHTNYTMEHIRVGWELLLTTIARTINEVETQILTRDAKGITQEQMNEFRAS 761
            ++EAL+ DNK+T ++   +   W+ L     R  + +E QI  R+  G+T+E + EF   
Sbjct: 2272 MEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFSMM 2331

Query: 762  FNHFDRRKNGLMDHEDFRACLISMGYDL-------GEAEFARIMTLVDPNGQGTVTFQSF 814
            F HFD+ K+G ++H++F++CL S+GYDL        + EF  I+  VDPN  G V+ Q +
Sbjct: 2332 FKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDGHVSLQEY 2391

Query: 815  IDFM-TRETADTDTAEQVIASFRILASD-KPYILAEELRRELPPDQAQYCIKRMPAY-SG 871
            + FM +RET +  ++E++ ++FR L+S+ KPY+  EEL + L  +QA YC+  M  Y  G
Sbjct: 2392 MAFMISRETENVKSSEEIESAFRALSSEGKPYVTKEELYQNLTREQADYCVSHMKPYVDG 2451

Query: 872  PG-SVPGALDYAAFSSALY 889
             G  +P A DY  F+ +L+
Sbjct: 2452 KGRELPTAFDYVEFTRSLF 2470



 Score = 90.9 bits (224), Expect = 5e-18
 Identities = 108/512 (21%), Positives = 213/512 (41%), Gaps = 47/512 (9%)

Query: 260  EQAETAANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKK 319
            ++ +T   R  K+ ++       + E  RL  +    +     W++ +      +   + 
Sbjct: 1737 DKRDTINGRFQKIKSMAASRRAKLNESHRL-HQFFRDMDDEESWIKEKKLLVGSEDYGRD 1795

Query: 320  LEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLE 379
            L   ++ R+KHK  + +           L T  ++S+       E +         QRL 
Sbjct: 1796 LTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQ---------QRLA 1846

Query: 380  QAEKGYEEWLLNEIRRLERLEHLAE--KFRQKASTHETWAYGKEQILLQKDYESASLTEV 437
            Q  + ++E       R +RLE   E  +F       E W   K  ++  +DY   +L  +
Sbjct: 1847 QFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGD-TLAAI 1905

Query: 438  RALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLT 497
            + LL+KHEAFE+D   H+DRV  +    Q+L + + H   N++ + + +       G ++
Sbjct: 1906 QGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGL------NGKVS 1959

Query: 498  QKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITA 557
               + A +R  KL E  +   L+F  +A    +W+      L+       +  +Q+L+T 
Sbjct: 1960 DLEKAAAQRKAKLDE--NSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTK 2017

Query: 558  HEQFKATLPEADGER-QSIMAIQNEV--EKVIQSYNIRISSSNPYSTVTMDELRTKWDKV 614
             E F A L     E   +I A+++++   K +QS  I    ++         L  +W ++
Sbjct: 2018 QETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHAS---------LMKRWSQL 2068

Query: 615  KQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIAR----SSIQITGA 670
                  R + L E  +     E L   FA +A+A   W +N  E++      +S++   A
Sbjct: 2069 LANSAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKA 2128

Query: 671  LEDQMNQLKQYEHNIINYKNNIDKLEGDHQLIQEALVFDNKHTNYTMEHIRVGWELLLTT 730
            L +  +    +  ++ + + + ++L    + I+   V  N +T +TME +   W      
Sbjct: 2129 LREAHD---AFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWR----N 2181

Query: 731  IARTINEVETQILTRDAKGITQEQMNEFRASF 762
            + + I E E ++     +   QE+ ++ R  F
Sbjct: 2182 LQKIIKERELELQKEQRR---QEENDKLRQEF 2210



 Score = 77.4 bits (189), Expect = 5e-14
 Identities = 112/553 (20%), Positives = 218/553 (39%), Gaps = 78/553 (14%)

Query: 160  WCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPDLIDYSKLNKDDPIGNINLAMEIA 219
            W QR+    + + +Q FH   +      A              LN +D   +++    + 
Sbjct: 1434 WVQRRMMLDQCLELQLFHRDCEQAENWMAAREAF---------LNTEDKGDSLDSVEALI 1484

Query: 220  EKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQAETAANRICKVL-AVNQE 278
            +KH D  K ++ ++        E+             AG       ++R  +VL    + 
Sbjct: 1485 KKHEDFDKAINVQE--------EKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRL 1536

Query: 279  NERLMEEYERLA-SELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHKPPKVQE 337
              +++E+  +L  S+ L+   R +  +E    EK   A  +  +D  + + KH+  +  E
Sbjct: 1537 KAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQSKHQKHQAFE 1596

Query: 338  KCQLEINFNTLQTKLRISN----RPAFMPSEGKM---VSDIAGAWQRLEQ--AEKGYEEW 388
              +L  N + ++  + + N    R A   SE  +   ++ +A  WQ L Q  AEK  +  
Sbjct: 1597 -AELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQK-- 1653

Query: 389  LLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFE 448
             L E  +        + F       + W    E +L  +DY    L  V  LL+KH+  E
Sbjct: 1654 -LKEANK-------QQNFNTGIKDFDFWLSEVEALLASEDY-GKDLASVNNLLKKHQLLE 1704

Query: 449  SDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERME 508
            +D++AH+DR++ + + A  L      D   V D+   I  ++ ++ ++   RR  L    
Sbjct: 1705 ADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESH 1764

Query: 509  KLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEA 568
            +L +    +  E         +W++     +        +  +Q+L   H++ +A L   
Sbjct: 1765 RLHQFFRDMDDE--------ESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAH 1816

Query: 569  DGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTK-------WDKVKQLVPIR 621
            +   Q ++               ++S  N   T+  +E++ +       W ++KQL   R
Sbjct: 1817 EPAIQGVL-----------DTGKKLSDDN---TIGKEEIQQRLAQFVEHWKELKQLAAAR 1862

Query: 622  DQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQIT-GALEDQMNQLKQ 680
             Q L+E L  Q        QF A       WI  KM  +A      T  A++  + + + 
Sbjct: 1863 GQRLEESLEYQ--------QFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEA 1914

Query: 681  YEHNIINYKNNID 693
            +E +   +K+ ++
Sbjct: 1915 FETDFTVHKDRVN 1927



 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 94/445 (21%), Positives = 174/445 (39%), Gaps = 46/445 (10%)

Query: 218 IAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQAETAANRICKVLAVNQ 277
           + +KH D  K L A++   T   DE A     +  Y         + A  R   +   N 
Sbjct: 505 LLKKHEDFEKSLSAQEEKITAL-DEFATKLIQNNHY------AMEDVATRRDALLSRRNA 557

Query: 278 ENERLMEEYERLASEL-LEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHKPPKVQ 336
            +ER M    +LA    L+   R    L++   EK   A  +  +D  + + K +  +  
Sbjct: 558 LHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQAF 617

Query: 337 EKCQLEINFNTLQTKLRISNRPAFMPSEGK-----MVSDIAGAWQRLEQAEKGYEEWLLN 391
           E  +L  N + +    +   +   +    K      ++++   W++L +A +      L 
Sbjct: 618 E-AELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATE------LK 670

Query: 392 EIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDL 451
            I+  E  +   ++F +     E W Y  E  L   DY    LT V+ L +KH   E+D+
Sbjct: 671 GIKLREANQQ--QQFNRNVEDIELWLYEVEGHLASDDY-GKDLTNVQNLQKKHALLEADV 727

Query: 452 AAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLL 511
           AAHQDR++ I   A++  +  + DA N+  + + +  +++ L      R++ L    +L 
Sbjct: 728 AAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQ 787

Query: 512 ETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGE 571
           +    +  E          W+               +  +Q+L+  H+  +A   E  G 
Sbjct: 788 QLFRDVEDE--------ETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQA---EIAGH 836

Query: 572 RQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQEELAR 631
              I A+  +   +++  +             + EL  KW+ +K     R Q L++ L  
Sbjct: 837 EPRIKAVTQKGNAMVEEGHFAAEDVK----AKLHELNQKWEALKAKASQRRQDLEDSLQA 892

Query: 632 QHANERLRRQFAAQANAIGPWIQNK 656
           Q        Q+ A AN    W++ K
Sbjct: 893 Q--------QYFADANEAESWMREK 909



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 78/301 (25%), Positives = 130/301 (43%), Gaps = 32/301 (10%)

Query: 285 EYERLASELLEWI--RRTIPWLENRTPE-KTMQAMQKKLEDFRDYRRKHKPPKVQEKCQL 341
           +Y R   ++++WI  +  I   E    + + ++ +QKK E+F+     H+  +V E    
Sbjct: 153 QYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEE-RVNE---- 207

Query: 342 EINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEH 401
               N    KL     P     + K   ++  AWQRL    KG        ++R  +L  
Sbjct: 208 ---VNQFAAKLIQEQHPEEELIKTKQ-DEVNAAWQRL----KGLA------LQRQGKLFG 253

Query: 402 LAEKFRQKASTHET--WAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVE 459
            AE  R      ET  W   KEQ++   D+    L  V+ALLRKHE  E DLAA +D+V+
Sbjct: 254 AAEVQRFNRDVDETISWIKEKEQLMASDDF-GRDLASVQALLRKHEGLERDLAALEDKVK 312

Query: 460 QIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALE---RMEKLLETIDQ 516
            + A A  L +     A  +  + +++   W+++ TL  +R   L    R+++ L     
Sbjct: 313 ALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRD 372

Query: 517 LHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIM 576
           L   +        N  E A +      ++   +E +  I AHE    +   AD   Q+++
Sbjct: 373 L-TSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHED---SFKSADESGQALL 428

Query: 577 A 577
           A
Sbjct: 429 A 429



 Score = 64.3 bits (155), Expect = 5e-10
 Identities = 83/384 (21%), Positives = 166/384 (43%), Gaps = 55/384 (14%)

Query: 278 ENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHKPPKVQE 337
           E+    + ++R A EL +WI+           EK   A  +  +D  + + K +  +  E
Sbjct: 41  EDSYRFQFFQRDAEELEKWIQ-----------EKLQIASDENYKDPTNLQGKLQKHQAFE 89

Query: 338 KCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIR--- 394
             +++ N   +   +++      M SEG   S+      RL +  + +E  LL ++R   
Sbjct: 90  -AEVQANSGAI---VKLDETGNLMISEGHFASETIRT--RLMELHRQWE-LLLEKMREKG 142

Query: 395 -RLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAA 453
            +L + + L +  R+     + W   KE I+  ++     L  V  L +K E F++D+AA
Sbjct: 143 IKLLQAQKLVQYLRECEDVMD-WINDKEAIVTSEEL-GQDLEHVEVLQKKFEEFQTDMAA 200

Query: 454 HQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLET 513
           H++RV ++   A +L +  + +   +  +  ++   W RL  L      AL+R  KL   
Sbjct: 201 HEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGL------ALQRQGKLFGA 254

Query: 514 IDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQ 573
            +     F +      +W++   + +        +  +Q+L+  HE          G  +
Sbjct: 255 AEVQR--FNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHE----------GLER 302

Query: 574 SIMAIQNEVEKVIQSYNIRISSSNPYST----VTMDELRTKWDKVKQLVPIRDQSLQEEL 629
            + A++++V+ +    + R+  S+P S     V  +EL T W++++ L         E  
Sbjct: 303 DLAALEDKVKALCAEAD-RLQQSHPLSATQIQVKREELITNWEQIRTLA-------AERH 354

Query: 630 ARQHANERLRRQFAAQANAIGPWI 653
           AR + + RL+R F A    +  W+
Sbjct: 355 ARLNDSYRLQR-FLADFRDLTSWV 377



 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 47/207 (22%), Positives = 84/207 (40%), Gaps = 17/207 (8%)

Query: 368  VSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQK 427
            + ++   W+ L+Q        L  E  +L    H  ++F + A   + W   K Q L   
Sbjct: 1208 IKELNERWRSLQQ--------LAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTD 1259

Query: 428  DYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKIC 487
            +Y    L  V+AL RKHE FE DLAA  D+V  +   A+ L +     A ++ ++C ++ 
Sbjct: 1260 NY-GHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELN 1318

Query: 488  DQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHS 547
              W  LG    +R+  L     L          F        +W+ G    +    +   
Sbjct: 1319 QAWSSLGKRADQRKAKLGDSHDL--------QRFLSDFRDLMSWINGIRGLVSSDELAKD 1370

Query: 548  IEEIQSLITAHEQFKATLPEADGERQS 574
            +   ++L+  H++ +  +    G  Q+
Sbjct: 1371 VTGAEALLERHQEHRTEIDARAGTFQA 1397



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 74/342 (21%), Positives = 148/342 (43%), Gaps = 37/342 (10%)

Query: 390 LNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFES 449
           LN+  RL+R   LA+ FR   S    W   + + L+  D  ++ +    ALL +H+  + 
Sbjct: 357 LNDSYRLQRF--LAD-FRDLTS----WVT-EMKALINADELASDVAGAEALLDRHQEHKG 408

Query: 450 DLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEK 509
           ++ AH+D  +      Q L    ++ +  V ++   + ++   L  L + RR+  E+   
Sbjct: 409 EIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMD 468

Query: 510 LLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEAD 569
           L     QL   F +     +NWM      L +  +  S++ +++L+  HE F+ +L    
Sbjct: 469 L-----QL---FYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSL---S 517

Query: 570 GERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQEEL 629
            + + I A+     K+IQ        +N Y+   M+++ T+ D +      R  +L E  
Sbjct: 518 AQEEKITALDEFATKLIQ--------NNHYA---MEDVATRRDALLS----RRNALHERA 562

Query: 630 AR---QHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITGALEDQMNQLKQYEHNII 686
            R   Q A+    +QF   ++ +  W+  KM+     + +    L+ ++ + + +E  + 
Sbjct: 563 MRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELS 622

Query: 687 NYKNNIDKLEGDHQLIQEALVFDNKHTNYTMEHIRVGWELLL 728
             ++ ID LE   Q + +   +        M  +   W+ LL
Sbjct: 623 ANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLL 664



 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 69/318 (21%), Positives = 134/318 (42%), Gaps = 32/318 (10%)

Query: 414 ETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDY 473
           + W   +E  LL +D    SL  V ALL+KHE FE  L+A ++++  +   A +L + ++
Sbjct: 480 DNWMSKQEAFLLNEDLGD-SLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNH 538

Query: 474 HDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHL-EFAKRAAPFNNWM 532
           +   +V  R   +  + + L     +RR  L          D  HL +F + +    +W+
Sbjct: 539 YAMEDVATRRDALLSRRNALHERAMRRRAQL---------ADSFHLQQFFRDSDELKSWV 589

Query: 533 EGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIR 592
              M+   D         +Q  +  H+ F+A   E    +  I A++   +K+I   +  
Sbjct: 590 NEKMKTATDE-AYKDPSNLQGKVQKHQAFEA---ELSANQSRIDALEKAGQKLIDVNHY- 644

Query: 593 ISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPW 652
              +       M+E+ + W K+ +   ++   L+E      AN+  ++QF      I  W
Sbjct: 645 ---AKDEVAARMNEVISLWKKLLEATELKGIKLRE------ANQ--QQQFNRNVEDIELW 693

Query: 653 IQNKMEEIARSSIQITGALEDQMNQLKQY---EHNIINYKNNIDKLEGDHQLIQEALVFD 709
           +      +A  S      L +  N  K++   E ++  +++ ID +    +  Q+A  FD
Sbjct: 694 LYEVEGHLA--SDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFD 751

Query: 710 NKHTNYTMEHIRVGWELL 727
            ++     E +   +E L
Sbjct: 752 AENIKKKQEALVARYEAL 769



 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 65/374 (17%), Positives = 145/374 (38%), Gaps = 28/374 (7%)

Query: 362 PSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLE--HLAEKFRQKASTHETWAYG 419
           PS  K++       +R +Q    Y  +      R ++LE  +  + F++ A   E W   
Sbjct: 3   PSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQE 62

Query: 420 KEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNV 479
           K QI   ++Y+    T ++  L+KH+AFE+++ A+   + ++      +    +  +  +
Sbjct: 63  KLQIASDENYKDP--TNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETI 120

Query: 480 NDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDL 539
             R  ++  QW+    L +K R   E+  KLL+   Q  +++ +      +W+      +
Sbjct: 121 RTRLMELHRQWE---LLLEKMR---EKGIKLLQA--QKLVQYLRECEDVMDWINDKEAIV 172

Query: 540 QDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPY 599
               +   +E ++ L    E+F+  +       + +  +     K+IQ  +         
Sbjct: 173 TSEELGQDLEHVEVLQKKFEEFQTDMA---AHEERVNEVNQFAAKLIQEQH----PEEEL 225

Query: 600 STVTMDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEE 659
                DE+   W ++K L   R   L      Q  N  +    +        WI+ K + 
Sbjct: 226 IKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETIS--------WIKEKEQL 277

Query: 660 IARSSI-QITGALEDQMNQLKQYEHNIINYKNNIDKLEGDHQLIQEALVFDNKHTNYTME 718
           +A     +   +++  + + +  E ++   ++ +  L  +   +Q++            E
Sbjct: 278 MASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKRE 337

Query: 719 HIRVGWELLLTTIA 732
            +   WE + T  A
Sbjct: 338 ELITNWEQIRTLAA 351



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 47/198 (23%), Positives = 86/198 (43%), Gaps = 17/198 (8%)

Query: 280 ERLMEEYERLASEL-LEWIRRTIP----WLENRTPEKTMQAMQKKLEDFRDYRRKHKPPK 334
           E ++   ++LA  L L+ + R +     W+  + P        K L   ++  +KH    
Sbjct: 771 EPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKH---- 826

Query: 335 VQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIR 394
             +  Q EI  +  + K  ++ +   M  EG   ++   A  +L +  + +E       +
Sbjct: 827 --QALQAEIAGHEPRIKA-VTQKGNAMVEEGHFAAEDVKA--KLHELNQKWEALKAKASQ 881

Query: 395 RLERLEHL--AEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLA 452
           R + LE    A+++   A+  E+W   KE I+   DY         ALL+KHEA  SDL+
Sbjct: 882 RRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDE-DSAEALLKKHEALMSDLS 940

Query: 453 AHQDRVEQIAAIAQELNE 470
           A+   ++ +   AQ   +
Sbjct: 941 AYGSSIQALREQAQSCRQ 958



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 80/426 (18%), Positives = 160/426 (37%), Gaps = 63/426 (14%)

Query: 283  MEEYERLASELLEWIRRTIPWLENRT---PEKTMQAMQKKLEDFRDYRRKHKPPKVQEKC 339
            ++ + R A E  EWI      L          ++QA+Q+K E F            ++  
Sbjct: 1235 VQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFE-----------RDLA 1283

Query: 340  QLEINFNTL-QTKLR-ISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLE 397
             L    N+L +T  R I + P       +  +++  AW  L +     +  L +      
Sbjct: 1284 ALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDS----H 1339

Query: 398  RLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDR 457
             L+     FR   S    W  G    L+  D  +  +T   ALL +H+   +++ A    
Sbjct: 1340 DLQRFLSDFRDLMS----WINGIRG-LVSSDELAKDVTGAEALLERHQEHRTEIDARAGT 1394

Query: 458  VEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQ- 516
             +      Q+L    ++ +  +            +L  L Q+R +  +   +    +DQ 
Sbjct: 1395 FQAFEQFGQQLLAHGHYASPEIK----------QKLDILDQERADLEKAWVQRRMMLDQC 1444

Query: 517  LHLE-FAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSI 575
            L L+ F +      NWM      L       S++ +++LI  HE F              
Sbjct: 1445 LELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDF-----------DKA 1493

Query: 576  MAIQNEVEKVIQSYNIRISSSNPYS----TVTMDELRTKWDKVKQLVPIRDQSLQEELAR 631
            + +Q E    +Q++  ++ ++  Y+    +   +E+  +W ++K  +  +   L E    
Sbjct: 1494 INVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTL 1553

Query: 632  QHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITGALEDQMNQLKQYEHNIINYKNN 691
            Q        QF+   + I  WI  K++  +  S +    ++ +  + + +E  +     N
Sbjct: 1554 Q--------QFSRDVDEIEAWISEKLQTASDESYKDPTNIQSKHQKHQAFEAEL---HAN 1602

Query: 692  IDKLEG 697
             D++ G
Sbjct: 1603 ADRIRG 1608



 Score = 31.2 bits (69), Expect = 4.5
 Identities = 17/63 (26%), Positives = 35/63 (55%), Gaps = 8/63 (12%)

Query: 277  QENERLMEEYERLASELLEWIRRTIPWL--------ENRTPEKTMQAMQKKLEDFRDYRR 328
            +EN++L +E+ + A+   +WI+ T  +L        E+ T E  ++A ++K ++ R  R 
Sbjct: 2201 EENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRS 2260

Query: 329  KHK 331
            + K
Sbjct: 2261 QLK 2263


>gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
            isoform 1 [Homo sapiens]
          Length = 2477

 Score =  280 bits (717), Expect = 3e-75
 Identities = 165/499 (33%), Positives = 275/499 (55%), Gaps = 22/499 (4%)

Query: 405  KFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAA-HQDRVEQIAA 463
            +F  KA   E+W   KE  L   DY    L+ V+ LL K E F++ L A  Q+ +  I A
Sbjct: 1985 QFNWKADVVESWIGEKENSLKTDDY-GRDLSSVQTLLTKQETFDAGLQAFQQEGIANITA 2043

Query: 464  IAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAK 523
            +  +L    +  +  +  R   +  +W +L   +  R++ L   +     ++ L L FAK
Sbjct: 2044 LKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAK 2103

Query: 524  RAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVE 583
            +A+ FN+W E A EDL D    +S+EEI++L  AH+ F+++L  A  +   +     E++
Sbjct: 2104 KASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLA----ELD 2159

Query: 584  KVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFA 643
            + I+S+ +   +SNPY+  TM+ L   W  +++++  R+  LQ+E  RQ  N++LR++FA
Sbjct: 2160 RQIKSFRV---ASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFA 2216

Query: 644  AQANAIGPWIQNKMEEIARSSIQI--TGALEDQMNQLKQYEHNIINYKNNIDKLEGDHQL 701
              ANA   WIQ     +   S  +  +G LE Q+   K+    I   ++ + K+E     
Sbjct: 2217 QHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAA 2276

Query: 702  IQEALVFDNKHTNYTMEHIRVGWELLLTTIARTINEVETQILTRDAKGITQEQMNEFRAS 761
            ++EAL+ DNK+T ++   +   W+ L     R  + +E QI  R+  G+T+E + EF   
Sbjct: 2277 MEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFSMM 2336

Query: 762  FNHFDRRKNGLMDHEDFRACLISMGYDL-------GEAEFARIMTLVDPNGQGTVTFQSF 814
            F HFD+ K+G ++H++F++CL S+GYDL        + EF  I+  VDPN  G V+ Q +
Sbjct: 2337 FKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDGHVSLQEY 2396

Query: 815  IDFM-TRETADTDTAEQVIASFRILASD-KPYILAEELRRELPPDQAQYCIKRMPAY-SG 871
            + FM +RET +  ++E++ ++FR L+S+ KPY+  EEL + L  +QA YC+  M  Y  G
Sbjct: 2397 MAFMISRETENVKSSEEIESAFRALSSEGKPYVTKEELYQNLTREQADYCVSHMKPYVDG 2456

Query: 872  PG-SVPGALDYAAFSSALY 889
             G  +P A DY  F+ +L+
Sbjct: 2457 KGRELPTAFDYVEFTRSLF 2475



 Score = 90.9 bits (224), Expect = 5e-18
 Identities = 108/512 (21%), Positives = 213/512 (41%), Gaps = 47/512 (9%)

Query: 260  EQAETAANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKK 319
            ++ +T   R  K+ ++       + E  RL  +    +     W++ +      +   + 
Sbjct: 1742 DKRDTINGRFQKIKSMAASRRAKLNESHRL-HQFFRDMDDEESWIKEKKLLVGSEDYGRD 1800

Query: 320  LEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLE 379
            L   ++ R+KHK  + +           L T  ++S+       E +         QRL 
Sbjct: 1801 LTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQ---------QRLA 1851

Query: 380  QAEKGYEEWLLNEIRRLERLEHLAE--KFRQKASTHETWAYGKEQILLQKDYESASLTEV 437
            Q  + ++E       R +RLE   E  +F       E W   K  ++  +DY   +L  +
Sbjct: 1852 QFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGD-TLAAI 1910

Query: 438  RALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLT 497
            + LL+KHEAFE+D   H+DRV  +    Q+L + + H   N++ + + +       G ++
Sbjct: 1911 QGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGL------NGKVS 1964

Query: 498  QKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITA 557
               + A +R  KL E  +   L+F  +A    +W+      L+       +  +Q+L+T 
Sbjct: 1965 DLEKAAAQRKAKLDE--NSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTK 2022

Query: 558  HEQFKATLPEADGER-QSIMAIQNEV--EKVIQSYNIRISSSNPYSTVTMDELRTKWDKV 614
             E F A L     E   +I A+++++   K +QS  I    ++         L  +W ++
Sbjct: 2023 QETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHAS---------LMKRWSQL 2073

Query: 615  KQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIAR----SSIQITGA 670
                  R + L E  +     E L   FA +A+A   W +N  E++      +S++   A
Sbjct: 2074 LANSAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKA 2133

Query: 671  LEDQMNQLKQYEHNIINYKNNIDKLEGDHQLIQEALVFDNKHTNYTMEHIRVGWELLLTT 730
            L +  +    +  ++ + + + ++L    + I+   V  N +T +TME +   W      
Sbjct: 2134 LREAHD---AFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWR----N 2186

Query: 731  IARTINEVETQILTRDAKGITQEQMNEFRASF 762
            + + I E E ++     +   QE+ ++ R  F
Sbjct: 2187 LQKIIKERELELQKEQRR---QEENDKLRQEF 2215



 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 94/445 (21%), Positives = 174/445 (39%), Gaps = 46/445 (10%)

Query: 218 IAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQAETAANRICKVLAVNQ 277
           + +KH D  K L A++   T   DE A     +  Y         + A  R   +   N 
Sbjct: 505 LLKKHEDFEKSLSAQEEKITAL-DEFATKLIQNNHY------AMEDVATRRDALLSRRNA 557

Query: 278 ENERLMEEYERLASEL-LEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHKPPKVQ 336
            +ER M    +LA    L+   R    L++   EK   A  +  +D  + + K +  +  
Sbjct: 558 LHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQAF 617

Query: 337 EKCQLEINFNTLQTKLRISNRPAFMPSEGK-----MVSDIAGAWQRLEQAEKGYEEWLLN 391
           E  +L  N + +    +   +   +    K      ++++   W++L +A +      L 
Sbjct: 618 E-AELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATE------LK 670

Query: 392 EIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDL 451
            I+  E  +   ++F +     E W Y  E  L   DY    LT V+ L +KH   E+D+
Sbjct: 671 GIKLREANQQ--QQFNRNVEDIELWLYEVEGHLASDDY-GKDLTNVQNLQKKHALLEADV 727

Query: 452 AAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLL 511
           AAHQDR++ I   A++  +  + DA N+  + + +  +++ L      R++ L    +L 
Sbjct: 728 AAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQ 787

Query: 512 ETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGE 571
           +    +  E          W+               +  +Q+L+  H+  +A   E  G 
Sbjct: 788 QLFRDVEDE--------ETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQA---EIAGH 836

Query: 572 RQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQEELAR 631
              I A+  +   +++  +             + EL  KW+ +K     R Q L++ L  
Sbjct: 837 EPRIKAVTQKGNAMVEEGHFAAEDVK----AKLHELNQKWEALKAKASQRRQDLEDSLQA 892

Query: 632 QHANERLRRQFAAQANAIGPWIQNK 656
           Q        Q+ A AN    W++ K
Sbjct: 893 Q--------QYFADANEAESWMREK 909



 Score = 71.2 bits (173), Expect = 4e-12
 Identities = 111/557 (19%), Positives = 217/557 (38%), Gaps = 81/557 (14%)

Query: 160  WCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPDLIDYSKLNKDDPIGNINLAMEIA 219
            W QR+    + + +Q FH   +      A              LN +D   +++    + 
Sbjct: 1434 WVQRRMMLDQCLELQLFHRDCEQAENWMAAREAF---------LNTEDKGDSLDSVEALI 1484

Query: 220  EKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQAETAANRICKVL-AVNQE 278
            +KH D  K ++ ++        E+             AG       ++R  +VL    + 
Sbjct: 1485 KKHEDFDKAINVQE--------EKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRL 1536

Query: 279  NERLMEEYERLA-SELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHKPPKVQE 337
              +++E+  +L  S+ L+   R +  +E    EK   A  +  +D  + +      K Q+
Sbjct: 1537 KAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQK 1596

Query: 338  ----KCQLEINFNTLQTKLRISN----RPAFMPSEGKM---VSDIAGAWQRLEQ--AEKG 384
                + +L  N + ++  + + N    R A   SE  +   ++ +A  WQ L Q  AEK 
Sbjct: 1597 HQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKS 1656

Query: 385  YEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKH 444
             +   L E  +        + F       + W    E +L  +DY    L  V  LL+KH
Sbjct: 1657 QK---LKEANK-------QQNFNTGIKDFDFWLSEVEALLASEDY-GKDLASVNNLLKKH 1705

Query: 445  EAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREAL 504
            +  E+D++AH+DR++ + + A  L      D   V D+   I  ++ ++ ++   RR  L
Sbjct: 1706 QLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKL 1765

Query: 505  ERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKAT 564
                +L +    +  E         +W++     +        +  +Q+L   H++ +A 
Sbjct: 1766 NESHRLHQFFRDMDDE--------ESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAE 1817

Query: 565  LPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTK-------WDKVKQL 617
            L   +   Q ++               ++S  N   T+  +E++ +       W ++KQL
Sbjct: 1818 LAAHEPAIQGVL-----------DTGKKLSDDN---TIGKEEIQQRLAQFVEHWKELKQL 1863

Query: 618  VPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQIT-GALEDQMN 676
               R Q L+E L  Q        QF A       WI  KM  +A      T  A++  + 
Sbjct: 1864 AAARGQRLEESLEYQ--------QFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLK 1915

Query: 677  QLKQYEHNIINYKNNID 693
            + + +E +   +K+ ++
Sbjct: 1916 KHEAFETDFTVHKDRVN 1932



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 78/301 (25%), Positives = 130/301 (43%), Gaps = 32/301 (10%)

Query: 285 EYERLASELLEWI--RRTIPWLENRTPE-KTMQAMQKKLEDFRDYRRKHKPPKVQEKCQL 341
           +Y R   ++++WI  +  I   E    + + ++ +QKK E+F+     H+  +V E    
Sbjct: 153 QYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEE-RVNE---- 207

Query: 342 EINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEH 401
               N    KL     P     + K   ++  AWQRL    KG        ++R  +L  
Sbjct: 208 ---VNQFAAKLIQEQHPEEELIKTKQ-DEVNAAWQRL----KGLA------LQRQGKLFG 253

Query: 402 LAEKFRQKASTHET--WAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVE 459
            AE  R      ET  W   KEQ++   D+    L  V+ALLRKHE  E DLAA +D+V+
Sbjct: 254 AAEVQRFNRDVDETISWIKEKEQLMASDDF-GRDLASVQALLRKHEGLERDLAALEDKVK 312

Query: 460 QIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALE---RMEKLLETIDQ 516
            + A A  L +     A  +  + +++   W+++ TL  +R   L    R+++ L     
Sbjct: 313 ALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRD 372

Query: 517 LHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIM 576
           L   +        N  E A +      ++   +E +  I AHE    +   AD   Q+++
Sbjct: 373 L-TSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHED---SFKSADESGQALL 428

Query: 577 A 577
           A
Sbjct: 429 A 429



 Score = 64.3 bits (155), Expect = 5e-10
 Identities = 83/384 (21%), Positives = 166/384 (43%), Gaps = 55/384 (14%)

Query: 278 ENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHKPPKVQE 337
           E+    + ++R A EL +WI+           EK   A  +  +D  + + K +  +  E
Sbjct: 41  EDSYRFQFFQRDAEELEKWIQ-----------EKLQIASDENYKDPTNLQGKLQKHQAFE 89

Query: 338 KCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIR--- 394
             +++ N   +   +++      M SEG   S+      RL +  + +E  LL ++R   
Sbjct: 90  -AEVQANSGAI---VKLDETGNLMISEGHFASETIRT--RLMELHRQWE-LLLEKMREKG 142

Query: 395 -RLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAA 453
            +L + + L +  R+     + W   KE I+  ++     L  V  L +K E F++D+AA
Sbjct: 143 IKLLQAQKLVQYLRECEDVMD-WINDKEAIVTSEEL-GQDLEHVEVLQKKFEEFQTDMAA 200

Query: 454 HQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLET 513
           H++RV ++   A +L +  + +   +  +  ++   W RL  L      AL+R  KL   
Sbjct: 201 HEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGL------ALQRQGKLFGA 254

Query: 514 IDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQ 573
            +     F +      +W++   + +        +  +Q+L+  HE          G  +
Sbjct: 255 AEVQR--FNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHE----------GLER 302

Query: 574 SIMAIQNEVEKVIQSYNIRISSSNPYST----VTMDELRTKWDKVKQLVPIRDQSLQEEL 629
            + A++++V+ +    + R+  S+P S     V  +EL T W++++ L         E  
Sbjct: 303 DLAALEDKVKALCAEAD-RLQQSHPLSATQIQVKREELITNWEQIRTLA-------AERH 354

Query: 630 ARQHANERLRRQFAAQANAIGPWI 653
           AR + + RL+R F A    +  W+
Sbjct: 355 ARLNDSYRLQR-FLADFRDLTSWV 377



 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 47/207 (22%), Positives = 84/207 (40%), Gaps = 17/207 (8%)

Query: 368  VSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQK 427
            + ++   W+ L+Q        L  E  +L    H  ++F + A   + W   K Q L   
Sbjct: 1208 IKELNERWRSLQQ--------LAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTD 1259

Query: 428  DYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKIC 487
            +Y    L  V+AL RKHE FE DLAA  D+V  +   A+ L +     A ++ ++C ++ 
Sbjct: 1260 NY-GHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELN 1318

Query: 488  DQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHS 547
              W  LG    +R+  L     L          F        +W+ G    +    +   
Sbjct: 1319 QAWSSLGKRADQRKAKLGDSHDL--------QRFLSDFRDLMSWINGIRGLVSSDELAKD 1370

Query: 548  IEEIQSLITAHEQFKATLPEADGERQS 574
            +   ++L+  H++ +  +    G  Q+
Sbjct: 1371 VTGAEALLERHQEHRTEIDARAGTFQA 1397



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 74/342 (21%), Positives = 148/342 (43%), Gaps = 37/342 (10%)

Query: 390 LNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFES 449
           LN+  RL+R   LA+ FR   S    W   + + L+  D  ++ +    ALL +H+  + 
Sbjct: 357 LNDSYRLQRF--LAD-FRDLTS----WVT-EMKALINADELASDVAGAEALLDRHQEHKG 408

Query: 450 DLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEK 509
           ++ AH+D  +      Q L    ++ +  V ++   + ++   L  L + RR+  E+   
Sbjct: 409 EIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMD 468

Query: 510 LLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEAD 569
           L     QL   F +     +NWM      L +  +  S++ +++L+  HE F+ +L    
Sbjct: 469 L-----QL---FYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSL---S 517

Query: 570 GERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQEEL 629
            + + I A+     K+IQ        +N Y+   M+++ T+ D +      R  +L E  
Sbjct: 518 AQEEKITALDEFATKLIQ--------NNHYA---MEDVATRRDALLS----RRNALHERA 562

Query: 630 AR---QHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITGALEDQMNQLKQYEHNII 686
            R   Q A+    +QF   ++ +  W+  KM+     + +    L+ ++ + + +E  + 
Sbjct: 563 MRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELS 622

Query: 687 NYKNNIDKLEGDHQLIQEALVFDNKHTNYTMEHIRVGWELLL 728
             ++ ID LE   Q + +   +        M  +   W+ LL
Sbjct: 623 ANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLL 664



 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 69/318 (21%), Positives = 134/318 (42%), Gaps = 32/318 (10%)

Query: 414 ETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDY 473
           + W   +E  LL +D    SL  V ALL+KHE FE  L+A ++++  +   A +L + ++
Sbjct: 480 DNWMSKQEAFLLNEDLGD-SLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNH 538

Query: 474 HDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHL-EFAKRAAPFNNWM 532
           +   +V  R   +  + + L     +RR  L          D  HL +F + +    +W+
Sbjct: 539 YAMEDVATRRDALLSRRNALHERAMRRRAQL---------ADSFHLQQFFRDSDELKSWV 589

Query: 533 EGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIR 592
              M+   D         +Q  +  H+ F+A   E    +  I A++   +K+I   +  
Sbjct: 590 NEKMKTATDE-AYKDPSNLQGKVQKHQAFEA---ELSANQSRIDALEKAGQKLIDVNHY- 644

Query: 593 ISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPW 652
              +       M+E+ + W K+ +   ++   L+E      AN+  ++QF      I  W
Sbjct: 645 ---AKDEVAARMNEVISLWKKLLEATELKGIKLRE------ANQ--QQQFNRNVEDIELW 693

Query: 653 IQNKMEEIARSSIQITGALEDQMNQLKQY---EHNIINYKNNIDKLEGDHQLIQEALVFD 709
           +      +A  S      L +  N  K++   E ++  +++ ID +    +  Q+A  FD
Sbjct: 694 LYEVEGHLA--SDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFD 751

Query: 710 NKHTNYTMEHIRVGWELL 727
            ++     E +   +E L
Sbjct: 752 AENIKKKQEALVARYEAL 769



 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 65/374 (17%), Positives = 145/374 (38%), Gaps = 28/374 (7%)

Query: 362 PSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLE--HLAEKFRQKASTHETWAYG 419
           PS  K++       +R +Q    Y  +      R ++LE  +  + F++ A   E W   
Sbjct: 3   PSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQE 62

Query: 420 KEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNV 479
           K QI   ++Y+    T ++  L+KH+AFE+++ A+   + ++      +    +  +  +
Sbjct: 63  KLQIASDENYKDP--TNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETI 120

Query: 480 NDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDL 539
             R  ++  QW+    L +K R   E+  KLL+   Q  +++ +      +W+      +
Sbjct: 121 RTRLMELHRQWE---LLLEKMR---EKGIKLLQA--QKLVQYLRECEDVMDWINDKEAIV 172

Query: 540 QDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPY 599
               +   +E ++ L    E+F+  +       + +  +     K+IQ  +         
Sbjct: 173 TSEELGQDLEHVEVLQKKFEEFQTDMA---AHEERVNEVNQFAAKLIQEQH----PEEEL 225

Query: 600 STVTMDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEE 659
                DE+   W ++K L   R   L      Q  N  +    +        WI+ K + 
Sbjct: 226 IKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETIS--------WIKEKEQL 277

Query: 660 IARSSI-QITGALEDQMNQLKQYEHNIINYKNNIDKLEGDHQLIQEALVFDNKHTNYTME 718
           +A     +   +++  + + +  E ++   ++ +  L  +   +Q++            E
Sbjct: 278 MASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKRE 337

Query: 719 HIRVGWELLLTTIA 732
            +   WE + T  A
Sbjct: 338 ELITNWEQIRTLAA 351



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 47/198 (23%), Positives = 86/198 (43%), Gaps = 17/198 (8%)

Query: 280 ERLMEEYERLASEL-LEWIRRTIP----WLENRTPEKTMQAMQKKLEDFRDYRRKHKPPK 334
           E ++   ++LA  L L+ + R +     W+  + P        K L   ++  +KH    
Sbjct: 771 EPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKH---- 826

Query: 335 VQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIR 394
             +  Q EI  +  + K  ++ +   M  EG   ++   A  +L +  + +E       +
Sbjct: 827 --QALQAEIAGHEPRIKA-VTQKGNAMVEEGHFAAEDVKA--KLHELNQKWEALKAKASQ 881

Query: 395 RLERLEHL--AEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLA 452
           R + LE    A+++   A+  E+W   KE I+   DY         ALL+KHEA  SDL+
Sbjct: 882 RRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDE-DSAEALLKKHEALMSDLS 940

Query: 453 AHQDRVEQIAAIAQELNE 470
           A+   ++ +   AQ   +
Sbjct: 941 AYGSSIQALREQAQSCRQ 958



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 81/428 (18%), Positives = 158/428 (36%), Gaps = 62/428 (14%)

Query: 283  MEEYERLASELLEWIRRTIPWLENRT---PEKTMQAMQKKLEDFRDYRRKHKPPKVQEKC 339
            ++ + R A E  EWI      L          ++QA+Q+K E F            ++  
Sbjct: 1235 VQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFE-----------RDLA 1283

Query: 340  QLEINFNTL-QTKLR-ISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLE 397
             L    N+L +T  R I + P       +  +++  AW  L +     +  L +      
Sbjct: 1284 ALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDS----H 1339

Query: 398  RLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDR 457
             L+     FR   S    W  G    L+  D  +  +T   ALL +H+   +++ A    
Sbjct: 1340 DLQRFLSDFRDLMS----WINGIRG-LVSSDELAKDVTGAEALLERHQEHRTEIDARAGT 1394

Query: 458  VEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQ- 516
             +      Q+L    ++ +  +            +L  L Q+R +  +   +    +DQ 
Sbjct: 1395 FQAFEQFGQQLLAHGHYASPEIK----------QKLDILDQERADLEKAWVQRRMMLDQC 1444

Query: 517  LHLE-FAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSI 575
            L L+ F +      NWM      L       S++ +++LI  HE F              
Sbjct: 1445 LELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDF-----------DKA 1493

Query: 576  MAIQNEVEKVIQSYNIRISSSNPYS----TVTMDELRTKWDKVKQLVPIRDQSLQEELAR 631
            + +Q E    +Q++  ++ ++  Y+    +   +E+  +W ++K  +  +   L E    
Sbjct: 1494 INVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTL 1553

Query: 632  QHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITGALEDQMNQLKQYEHNIINYK-- 689
            Q        QF+   + I  WI  K++  +  S +    ++      K  +H     +  
Sbjct: 1554 Q--------QFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELH 1605

Query: 690  NNIDKLEG 697
             N D++ G
Sbjct: 1606 ANADRIRG 1613



 Score = 31.2 bits (69), Expect = 4.5
 Identities = 17/63 (26%), Positives = 35/63 (55%), Gaps = 8/63 (12%)

Query: 277  QENERLMEEYERLASELLEWIRRTIPWL--------ENRTPEKTMQAMQKKLEDFRDYRR 328
            +EN++L +E+ + A+   +WI+ T  +L        E+ T E  ++A ++K ++ R  R 
Sbjct: 2206 EENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRS 2265

Query: 329  KHK 331
            + K
Sbjct: 2266 QLK 2268


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score =  241 bits (614), Expect = 3e-63
 Identities = 193/652 (29%), Positives = 308/652 (47%), Gaps = 41/652 (6%)

Query: 15  DEDEYMIQEEEWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLML 74
           DE ++ IQ  E  R+   D   ++ Q+KTFT W N HL KA   I ++ ED R+G  L+ 
Sbjct: 7   DEQDF-IQAYEEVREKYKDER-DRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLIS 64

Query: 75  LLEVISGERLPKPDRGKMRFHKIANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTLGMI 134
           LLEV+SG+ LP+ ++G+MRFHK+ NV  ALDY+  + VKLV+I  ++I DGN K+TLG+I
Sbjct: 65  LLEVLSGDSLPR-EKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLI 123

Query: 135 WTIILRFAIQDISV----EETSAKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALI 190
           WTIIL F I DI V    E+ +AKE LLLW QR    Y+ +   NF +SW+DG    A+I
Sbjct: 124 WTIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAII 183

Query: 191 HRHRPDLIDYSKLNKDDPIGNINLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVS 250
           HRH+P LID +K+ +   + N++ A  +AE+ L + ++LD ED V+ P+PDE++I+TYVS
Sbjct: 184 HRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPED-VDVPQPDEKSIITYVS 242

Query: 251 CFYHAFAGAEQAETAANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPE 310
             Y A       +              E +   +EY  L   LL+W+R      E R   
Sbjct: 243 SLYDAMPRVPDVQDGVRA--------NELQLRWQEYRELVLLLLQWMRHHTAAFEERRFP 294

Query: 311 KTMQAMQKKLEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKL---RISNRPAFMPSEGKM 367
            + + ++     F  ++    P K  +K + +  + +L+  +   ++   P + P     
Sbjct: 295 SSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHP----- 349

Query: 368 VSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQK 427
             D+   W +L  A    E+ L +E  RLE L+ +  K + +A   E     +   LLQ 
Sbjct: 350 -LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEE-QLNQADALLQS 407

Query: 428 DYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKIC 487
           D    +  +V    ++    E DL      +  +    Q L +  +     +  R  ++ 
Sbjct: 408 DVRLLAAGKVP---QRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLH 464

Query: 488 DQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHS 547
           ++   + T    R +A   +      + Q+ L+  +R        +  +  LQD  ++  
Sbjct: 465 ERLVAIRTEYNLRLKA--GVAAPATQVAQVTLQSVQRRPELE---DSTLRYLQD--LLAW 517

Query: 548 IEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDEL 607
           +EE Q  +   E +   LP  + +  S   +   +E+         S     S  T    
Sbjct: 518 VEENQHRVDGAE-WGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAY 576

Query: 608 RTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEE 659
           R   D + +L     + L    AR  + E L   F A A     W+  K EE
Sbjct: 577 R---DCLGRLDLQYAKLLNSSKARLRSLESL-HSFVAAATKELMWLNEKEEE 624



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 102/559 (18%), Positives = 213/559 (38%), Gaps = 61/559 (10%)

Query: 212  INLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQAETAANRI-- 269
            + LA E A+K L   +   A  +    +  ++ +    S        AE A  AA     
Sbjct: 2022 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2081

Query: 270  CKVLAVNQ--ENERLMEEYERL-------------ASELLEWIRRTIPWLENRTPEKTMQ 314
             +V A  +  ++ R +EE ERL             A    E +R+       R  +    
Sbjct: 2082 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA 2141

Query: 315  AMQKK--LEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIA 372
            A+++K   +   +  +K     +++K Q+E    TL+ +L  ++    +  E ++    A
Sbjct: 2142 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE-ELQRLKA 2200

Query: 373  GAWQRLEQAEKGYEEWL-----LNEIRRLER--------------------LEHLAEKFR 407
             A +   Q  +  EE       + E+ +L+                     L+  AEK +
Sbjct: 2201 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2260

Query: 408  QKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQE 467
            Q A      +   ++    +      L + RAL  K    +        R++  A + Q+
Sbjct: 2261 QVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2320

Query: 468  LNELDYHDAVNVNDRCQKICDQWDR-----LGTLTQKRREAL------ERMEKLLETIDQ 516
              EL    A  + +  +++  Q          TL  +R+  L      ER++  +  + +
Sbjct: 2321 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2380

Query: 517  LHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIM 576
                  + A  F    E   E L    +  + E++  + T   Q + +  +A+  R++I 
Sbjct: 2381 AQARAEEDAQRFRKQAEEIGEKLHRTELA-TQEKVTLVQTLEIQRQQSDHDAERLREAIA 2439

Query: 577  AIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQ-LVPIRDQSLQEELARQHAN 635
             ++ E EK+ Q   +    S    TV  ++L  +   ++Q  +  +D  LQ E   +   
Sbjct: 2440 ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK 2499

Query: 636  ERLRRQF---AAQANAIGPWIQNKMEEIARSSIQITGALEDQMNQLKQYEHNIINYKNNI 692
             +L + F    A+A  +    Q + +++ +   ++  ++E+   +  + E  +   +  +
Sbjct: 2500 AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL 2559

Query: 693  DKLEGDHQLIQEALVFDNK 711
             +LE   +  +E L  +N+
Sbjct: 2560 QQLEQQRRQQEELLAEENQ 2578



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 91/429 (21%), Positives = 173/429 (40%), Gaps = 33/429 (7%)

Query: 260  EQAETAANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKK 319
            E+AE  A +  +     +E ER +E ++  A+E L  +R     +  +      +A ++K
Sbjct: 1594 EEAERRAQQQAEAERAREEAERELERWQLKANEALR-LRLQAEEVAQQKSLAQAEAEKQK 1652

Query: 320  LEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLE 379
             E  R+ RR+ K  + Q   Q E+    L+ + +++   A      +   ++       E
Sbjct: 1653 EEAEREARRRGKAEE-QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ--ELIRLRAETE 1709

Query: 380  QAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILL----QKDYESASLT 435
            Q E+   + L  E+ RL+R    A + RQ+          + ++LL    + + ES S +
Sbjct: 1710 QGEQ-QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1768

Query: 436  EVRALLRKHEAFE-SDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKI-CDQWDRL 493
            E      + EA    +LA    R+  +A  A+   +L   DA       +++  ++   +
Sbjct: 1769 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1828

Query: 494  GTLTQKRREAL----------ERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMF 543
            G  T+ + EA           ER+ +L E          ++AA     +E  +  L+   
Sbjct: 1829 GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 1888

Query: 544  IVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVT 603
                +E  + L+      + TL +     + I+A++   EK                +  
Sbjct: 1889 D-SELERQKGLV------EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1941

Query: 604  MDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNK--MEEIA 661
             D LR+K     +    R  + +EE  R+ A ER+++  AA+  A     Q K  +EE+ 
Sbjct: 1942 EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR---QRKAALEEVE 1998

Query: 662  RSSIQITGA 670
            R   ++  A
Sbjct: 1999 RLKAKVEEA 2007



 Score = 37.0 bits (84), Expect = 0.082
 Identities = 79/379 (20%), Positives = 151/379 (39%), Gaps = 32/379 (8%)

Query: 265  AANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFR 324
            A NR   +   +     L EE E++     E  R ++   E     +  +    +     
Sbjct: 2235 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALA 2294

Query: 325  DYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKG 384
            +   K K   VQE  +L+     LQ +  ++   A    E K    +A   Q+L +  +G
Sbjct: 2295 EKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDK--EQMA---QQLAEETQG 2349

Query: 385  YEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYES--ASLTEVRALLR 442
            ++  L  E  R  +LE  AE  R K    E     + Q   ++D +       E+   L 
Sbjct: 2350 FQRTL--EAERQRQLEMSAEAERLKLRVAEM---SRAQARAEEDAQRFRKQAEEIGEKLH 2404

Query: 443  KHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRRE 502
            + E       A Q++V  +  +  +  + D HDA  + +   ++  + ++L    Q+  +
Sbjct: 2405 RTEL------ATQEKVTLVQTLEIQRQQSD-HDAERLREAIAELEREKEKL----QQEAK 2453

Query: 503  ALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFK 562
             L+   + ++T+ Q  L    +A   +   E      ++ FI     +++ L      F+
Sbjct: 2454 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL------FQ 2507

Query: 563  ATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRD 622
              + +A   R+     Q ++E+  Q     +  +        + +R K ++++QL   R 
Sbjct: 2508 DEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRR 2567

Query: 623  QSLQEELARQHANERLRRQ 641
            Q  QEEL  +  N+RLR Q
Sbjct: 2568 Q--QEELLAEE-NQRLREQ 2583



 Score = 34.3 bits (77), Expect = 0.53
 Identities = 56/264 (21%), Positives = 105/264 (39%), Gaps = 61/264 (23%)

Query: 434  LTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQ--WD 491
            L  +  ++R  +  E  L AH++++++  A+   L EL+   A     R Q    Q  +D
Sbjct: 1074 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1133

Query: 492  RLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEI 551
             L       R+ L   +++ E + Q H    +R      W E   + L            
Sbjct: 1134 AL-------RDELRGAQEVGERLQQRH---GERDVEVERWRERVAQLL------------ 1171

Query: 552  QSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKW 611
                   E+++A L + D         Q E+E++ +       S++P      D  R + 
Sbjct: 1172 -------ERWQAVLAQTD-------VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ- 1216

Query: 612  DKVKQLVPIRD-QSLQEELARQHA-NERLRRQFAAQANAIGPWIQNKMEEIARSSIQITG 669
             +  Q +P+ D Q+++E+L ++ A  E + R               K+EE  R + Q   
Sbjct: 1217 -EQIQAMPLADSQAVREQLRQEQALLEEIERH------------GEKVEECQRFAKQ--- 1260

Query: 670  ALEDQMNQLKQYEHNIINYKNNID 693
                 +N +K YE  ++ YK  ++
Sbjct: 1261 ----YINAIKDYELQLVTYKAQLE 1280



 Score = 32.7 bits (73), Expect = 1.5
 Identities = 78/425 (18%), Positives = 163/425 (38%), Gaps = 63/425 (14%)

Query: 281  RLMEEYERLASELLEWIR---------RTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHK 331
            R +  Y   A  L  W++         + +P  +++   + ++  Q  LE+   +  K  
Sbjct: 1193 RQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK-- 1250

Query: 332  PPKVQEKCQ------------LEINFNTLQTKLRISNRPAFMP-----SEGKMVS--DIA 372
                 E+CQ             E+   T + +L     PA  P     SE  +    D+ 
Sbjct: 1251 ----VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLR 1306

Query: 373  GAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESA 432
              +  L      Y +++   +RR+E  E LAE  +Q+A   E  A  +  +  Q+    A
Sbjct: 1307 THYSELTTLTSQYIKFISETLRRMEEEERLAE--QQRAEERERLAEVEAALEKQRQLAEA 1364

Query: 433  SLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDR 492
                     R+ +  +  +     R E+ A  AQ+          ++ +  Q++    + 
Sbjct: 1365 HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKR-------SIQEELQQLRQSSEA 1417

Query: 493  LGTLTQKRREALERMEKLLE---TIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIE 549
                  ++ EA ER    +E    + +L LE  +R        EG ++ L+        +
Sbjct: 1418 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ---RGGAEGELQALRARAEEAEAQ 1474

Query: 550  EIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRT 609
            + Q+   A    +    E+  +RQ+ + + + V+   ++     +     +   ++ELR 
Sbjct: 1475 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEA-----AREKQRALQALEELRL 1529

Query: 610  KWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITG 669
            + ++ ++    R +  + E ARQ        Q +A+A      +Q+K    A  + Q+  
Sbjct: 1530 QAEEAER----RLRQAEVERARQVQVALETAQRSAEAE-----LQSKRASFAEKTAQLER 1580

Query: 670  ALEDQ 674
            +L+++
Sbjct: 1581 SLQEE 1585


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score =  240 bits (613), Expect = 4e-63
 Identities = 190/645 (29%), Positives = 304/645 (47%), Gaps = 47/645 (7%)

Query: 22  QEEEWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISG 81
           Q+E+ +RD        + Q+KTFT W N HL KA   I ++ ED R+G  L+ LLEV+SG
Sbjct: 34  QDEQDERD--------RVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSG 85

Query: 82  ERLPKPDRGKMRFHKIANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRF 141
           + LP+ ++G+MRFHK+ NV  ALDY+  + VKLV+I  ++I DGN K+TLG+IWTIIL F
Sbjct: 86  DSLPR-EKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHF 144

Query: 142 AIQDISV----EETSAKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPDL 197
            I DI V    E+ +AKE LLLW QR    Y+ +   NF +SW+DG    A+IHRH+P L
Sbjct: 145 QISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLL 204

Query: 198 IDYSKLNKDDPIGNINLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFA 257
           ID +K+ +   + N++ A  +AE+ L + ++LD ED V+ P+PDE++I+TYVS  Y A  
Sbjct: 205 IDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPED-VDVPQPDEKSIITYVSSLYDAMP 263

Query: 258 GAEQAETAANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQ 317
                +              E +   +EY  L   LL+W+R      E R    + + ++
Sbjct: 264 RVPDVQDGVRA--------NELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIE 315

Query: 318 KKLEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKL---RISNRPAFMPSEGKMVSDIAGA 374
                F  ++    P K  +K + +  + +L+  +   ++   P + P       D+   
Sbjct: 316 ILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHP------LDVEKE 369

Query: 375 WQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASL 434
           W +L  A    E+ L +E  RLE L+ +  K + +A   E     +   LLQ D    + 
Sbjct: 370 WGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEE-QLNQADALLQSDVRLLAA 428

Query: 435 TEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLG 494
            +V    ++    E DL      +  +    Q L +  +     +  R  ++ ++   + 
Sbjct: 429 GKVP---QRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIR 485

Query: 495 TLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSL 554
           T    R +A   +      + Q+ L+  +R        +  +  LQD  ++  +EE Q  
Sbjct: 486 TEYNLRLKA--GVAAPATQVAQVTLQSVQRRPELE---DSTLRYLQD--LLAWVEENQHR 538

Query: 555 ITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKV 614
           +   E +   LP  + +  S   +   +E+         S     S  T    R   D +
Sbjct: 539 VDGAE-WGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYR---DCL 594

Query: 615 KQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEE 659
            +L     + L    AR  + E L   F A A     W+  K EE
Sbjct: 595 GRLDLQYAKLLNSSKARLRSLESL-HSFVAAATKELMWLNEKEEE 638



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 102/559 (18%), Positives = 213/559 (38%), Gaps = 61/559 (10%)

Query: 212  INLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQAETAANRI-- 269
            + LA E A+K L   +   A  +    +  ++ +    S        AE A  AA     
Sbjct: 2036 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2095

Query: 270  CKVLAVNQ--ENERLMEEYERL-------------ASELLEWIRRTIPWLENRTPEKTMQ 314
             +V A  +  ++ R +EE ERL             A    E +R+       R  +    
Sbjct: 2096 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA 2155

Query: 315  AMQKK--LEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIA 372
            A+++K   +   +  +K     +++K Q+E    TL+ +L  ++    +  E ++    A
Sbjct: 2156 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE-ELQRLKA 2214

Query: 373  GAWQRLEQAEKGYEEWL-----LNEIRRLER--------------------LEHLAEKFR 407
             A +   Q  +  EE       + E+ +L+                     L+  AEK +
Sbjct: 2215 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2274

Query: 408  QKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQE 467
            Q A      +   ++    +      L + RAL  K    +        R++  A + Q+
Sbjct: 2275 QVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2334

Query: 468  LNELDYHDAVNVNDRCQKICDQWDR-----LGTLTQKRREAL------ERMEKLLETIDQ 516
              EL    A  + +  +++  Q          TL  +R+  L      ER++  +  + +
Sbjct: 2335 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2394

Query: 517  LHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIM 576
                  + A  F    E   E L    +  + E++  + T   Q + +  +A+  R++I 
Sbjct: 2395 AQARAEEDAQRFRKQAEEIGEKLHRTELA-TQEKVTLVQTLEIQRQQSDHDAERLREAIA 2453

Query: 577  AIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQ-LVPIRDQSLQEELARQHAN 635
             ++ E EK+ Q   +    S    TV  ++L  +   ++Q  +  +D  LQ E   +   
Sbjct: 2454 ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK 2513

Query: 636  ERLRRQF---AAQANAIGPWIQNKMEEIARSSIQITGALEDQMNQLKQYEHNIINYKNNI 692
             +L + F    A+A  +    Q + +++ +   ++  ++E+   +  + E  +   +  +
Sbjct: 2514 AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL 2573

Query: 693  DKLEGDHQLIQEALVFDNK 711
             +LE   +  +E L  +N+
Sbjct: 2574 QQLEQQRRQQEELLAEENQ 2592



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 91/429 (21%), Positives = 173/429 (40%), Gaps = 33/429 (7%)

Query: 260  EQAETAANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKK 319
            E+AE  A +  +     +E ER +E ++  A+E L  +R     +  +      +A ++K
Sbjct: 1608 EEAERRAQQQAEAERAREEAERELERWQLKANEALR-LRLQAEEVAQQKSLAQAEAEKQK 1666

Query: 320  LEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLE 379
             E  R+ RR+ K  + Q   Q E+    L+ + +++   A      +   ++       E
Sbjct: 1667 EEAEREARRRGKAEE-QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ--ELIRLRAETE 1723

Query: 380  QAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILL----QKDYESASLT 435
            Q E+   + L  E+ RL+R    A + RQ+          + ++LL    + + ES S +
Sbjct: 1724 QGEQ-QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1782

Query: 436  EVRALLRKHEAFE-SDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKI-CDQWDRL 493
            E      + EA    +LA    R+  +A  A+   +L   DA       +++  ++   +
Sbjct: 1783 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1842

Query: 494  GTLTQKRREAL----------ERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMF 543
            G  T+ + EA           ER+ +L E          ++AA     +E  +  L+   
Sbjct: 1843 GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 1902

Query: 544  IVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVT 603
                +E  + L+      + TL +     + I+A++   EK                +  
Sbjct: 1903 D-SELERQKGLV------EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1955

Query: 604  MDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNK--MEEIA 661
             D LR+K     +    R  + +EE  R+ A ER+++  AA+  A     Q K  +EE+ 
Sbjct: 1956 EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR---QRKAALEEVE 2012

Query: 662  RSSIQITGA 670
            R   ++  A
Sbjct: 2013 RLKAKVEEA 2021



 Score = 37.0 bits (84), Expect = 0.082
 Identities = 79/379 (20%), Positives = 151/379 (39%), Gaps = 32/379 (8%)

Query: 265  AANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFR 324
            A NR   +   +     L EE E++     E  R ++   E     +  +    +     
Sbjct: 2249 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALA 2308

Query: 325  DYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKG 384
            +   K K   VQE  +L+     LQ +  ++   A    E K    +A   Q+L +  +G
Sbjct: 2309 EKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDK--EQMA---QQLAEETQG 2363

Query: 385  YEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYES--ASLTEVRALLR 442
            ++  L  E  R  +LE  AE  R K    E     + Q   ++D +       E+   L 
Sbjct: 2364 FQRTL--EAERQRQLEMSAEAERLKLRVAEM---SRAQARAEEDAQRFRKQAEEIGEKLH 2418

Query: 443  KHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRRE 502
            + E       A Q++V  +  +  +  + D HDA  + +   ++  + ++L    Q+  +
Sbjct: 2419 RTEL------ATQEKVTLVQTLEIQRQQSD-HDAERLREAIAELEREKEKL----QQEAK 2467

Query: 503  ALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFK 562
             L+   + ++T+ Q  L    +A   +   E      ++ FI     +++ L      F+
Sbjct: 2468 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL------FQ 2521

Query: 563  ATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRD 622
              + +A   R+     Q ++E+  Q     +  +        + +R K ++++QL   R 
Sbjct: 2522 DEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRR 2581

Query: 623  QSLQEELARQHANERLRRQ 641
            Q  QEEL  +  N+RLR Q
Sbjct: 2582 Q--QEELLAEE-NQRLREQ 2597



 Score = 34.3 bits (77), Expect = 0.53
 Identities = 56/264 (21%), Positives = 105/264 (39%), Gaps = 61/264 (23%)

Query: 434  LTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQ--WD 491
            L  +  ++R  +  E  L AH++++++  A+   L EL+   A     R Q    Q  +D
Sbjct: 1088 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1147

Query: 492  RLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEI 551
             L       R+ L   +++ E + Q H    +R      W E   + L            
Sbjct: 1148 AL-------RDELRGAQEVGERLQQRH---GERDVEVERWRERVAQLL------------ 1185

Query: 552  QSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKW 611
                   E+++A L + D         Q E+E++ +       S++P      D  R + 
Sbjct: 1186 -------ERWQAVLAQTD-------VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ- 1230

Query: 612  DKVKQLVPIRD-QSLQEELARQHA-NERLRRQFAAQANAIGPWIQNKMEEIARSSIQITG 669
             +  Q +P+ D Q+++E+L ++ A  E + R               K+EE  R + Q   
Sbjct: 1231 -EQIQAMPLADSQAVREQLRQEQALLEEIERH------------GEKVEECQRFAKQ--- 1274

Query: 670  ALEDQMNQLKQYEHNIINYKNNID 693
                 +N +K YE  ++ YK  ++
Sbjct: 1275 ----YINAIKDYELQLVTYKAQLE 1294



 Score = 32.7 bits (73), Expect = 1.5
 Identities = 78/425 (18%), Positives = 163/425 (38%), Gaps = 63/425 (14%)

Query: 281  RLMEEYERLASELLEWIR---------RTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHK 331
            R +  Y   A  L  W++         + +P  +++   + ++  Q  LE+   +  K  
Sbjct: 1207 RQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK-- 1264

Query: 332  PPKVQEKCQ------------LEINFNTLQTKLRISNRPAFMP-----SEGKMVS--DIA 372
                 E+CQ             E+   T + +L     PA  P     SE  +    D+ 
Sbjct: 1265 ----VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLR 1320

Query: 373  GAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESA 432
              +  L      Y +++   +RR+E  E LAE  +Q+A   E  A  +  +  Q+    A
Sbjct: 1321 THYSELTTLTSQYIKFISETLRRMEEEERLAE--QQRAEERERLAEVEAALEKQRQLAEA 1378

Query: 433  SLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDR 492
                     R+ +  +  +     R E+ A  AQ+          ++ +  Q++    + 
Sbjct: 1379 HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKR-------SIQEELQQLRQSSEA 1431

Query: 493  LGTLTQKRREALERMEKLLE---TIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIE 549
                  ++ EA ER    +E    + +L LE  +R        EG ++ L+        +
Sbjct: 1432 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ---RGGAEGELQALRARAEEAEAQ 1488

Query: 550  EIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRT 609
            + Q+   A    +    E+  +RQ+ + + + V+   ++     +     +   ++ELR 
Sbjct: 1489 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEA-----AREKQRALQALEELRL 1543

Query: 610  KWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITG 669
            + ++ ++    R +  + E ARQ        Q +A+A      +Q+K    A  + Q+  
Sbjct: 1544 QAEEAER----RLRQAEVERARQVQVALETAQRSAEAE-----LQSKRASFAEKTAQLER 1594

Query: 670  ALEDQ 674
            +L+++
Sbjct: 1595 SLQEE 1599


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score =  239 bits (611), Expect = 6e-63
 Identities = 186/630 (29%), Positives = 298/630 (47%), Gaps = 39/630 (6%)

Query: 37  EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPKPDRGKMRFHK 96
           ++ Q+KTFT W N HL KA   I ++ ED R+G  L+ LLEV+SG+ LP+ ++G+MRFHK
Sbjct: 41  DRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFHK 99

Query: 97  IANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISV----EETS 152
           + NV  ALDY+  + VKLV+I  ++I DGN K+TLG+IWTIIL F I DI V    E+ +
Sbjct: 100 LQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMT 159

Query: 153 AKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPDLIDYSKLNKDDPIGNI 212
           AKE LLLW QR    Y+ +   NF +SW+DG    A+IHRH+P LID +K+ +   + N+
Sbjct: 160 AKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENL 219

Query: 213 NLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQAETAANRICKV 272
           + A  +AE+ L + ++LD ED V+ P+PDE++I+TYVS  Y A       +         
Sbjct: 220 DQAFSVAERDLGVTRLLDPED-VDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRA---- 274

Query: 273 LAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHKP 332
                E +   +EY  L   LL+W+R      E R    + + ++     F  ++    P
Sbjct: 275 ----NELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELP 330

Query: 333 PKVQEKCQLEINFNTLQTKL---RISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWL 389
            K  +K + +  + +L+  +   ++   P + P       D+   W +L  A    E+ L
Sbjct: 331 AKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHP------LDVEKEWGKLHVAILEREKQL 384

Query: 390 LNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFES 449
            +E  RLE L+ +  K + +A   E     +   LLQ D    +  +V    ++    E 
Sbjct: 385 RSEFERLECLQRIVTKLQMEAGLCEE-QLNQADALLQSDVRLLAAGKVP---QRAGEVER 440

Query: 450 DLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEK 509
           DL      +  +    Q L +  +     +  R  ++ ++   + T    R +A   +  
Sbjct: 441 DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKA--GVAA 498

Query: 510 LLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEAD 569
               + Q+ L+  +R        +  +  LQD  ++  +EE Q  +   E +   LP  +
Sbjct: 499 PATQVAQVTLQSVQRRPELE---DSTLRYLQD--LLAWVEENQHRVDGAE-WGVDLPSVE 552

Query: 570 GERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQEEL 629
            +  S   +   +E+         S     S  T    R   D + +L     + L    
Sbjct: 553 AQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYR---DCLGRLDLQYAKLLNSSK 609

Query: 630 ARQHANERLRRQFAAQANAIGPWIQNKMEE 659
           AR  + E L   F A A     W+  K EE
Sbjct: 610 ARLRSLESL-HSFVAAATKELMWLNEKEEE 638



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 102/559 (18%), Positives = 213/559 (38%), Gaps = 61/559 (10%)

Query: 212  INLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQAETAANRI-- 269
            + LA E A+K L   +   A  +    +  ++ +    S        AE A  AA     
Sbjct: 2036 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2095

Query: 270  CKVLAVNQ--ENERLMEEYERL-------------ASELLEWIRRTIPWLENRTPEKTMQ 314
             +V A  +  ++ R +EE ERL             A    E +R+       R  +    
Sbjct: 2096 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA 2155

Query: 315  AMQKK--LEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIA 372
            A+++K   +   +  +K     +++K Q+E    TL+ +L  ++    +  E ++    A
Sbjct: 2156 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE-ELQRLKA 2214

Query: 373  GAWQRLEQAEKGYEEWL-----LNEIRRLER--------------------LEHLAEKFR 407
             A +   Q  +  EE       + E+ +L+                     L+  AEK +
Sbjct: 2215 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2274

Query: 408  QKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQE 467
            Q A      +   ++    +      L + RAL  K    +        R++  A + Q+
Sbjct: 2275 QVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2334

Query: 468  LNELDYHDAVNVNDRCQKICDQWDR-----LGTLTQKRREAL------ERMEKLLETIDQ 516
              EL    A  + +  +++  Q          TL  +R+  L      ER++  +  + +
Sbjct: 2335 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2394

Query: 517  LHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIM 576
                  + A  F    E   E L    +  + E++  + T   Q + +  +A+  R++I 
Sbjct: 2395 AQARAEEDAQRFRKQAEEIGEKLHRTELA-TQEKVTLVQTLEIQRQQSDHDAERLREAIA 2453

Query: 577  AIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQ-LVPIRDQSLQEELARQHAN 635
             ++ E EK+ Q   +    S    TV  ++L  +   ++Q  +  +D  LQ E   +   
Sbjct: 2454 ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK 2513

Query: 636  ERLRRQF---AAQANAIGPWIQNKMEEIARSSIQITGALEDQMNQLKQYEHNIINYKNNI 692
             +L + F    A+A  +    Q + +++ +   ++  ++E+   +  + E  +   +  +
Sbjct: 2514 AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL 2573

Query: 693  DKLEGDHQLIQEALVFDNK 711
             +LE   +  +E L  +N+
Sbjct: 2574 QQLEQQRRQQEELLAEENQ 2592



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 91/429 (21%), Positives = 173/429 (40%), Gaps = 33/429 (7%)

Query: 260  EQAETAANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKK 319
            E+AE  A +  +     +E ER +E ++  A+E L  +R     +  +      +A ++K
Sbjct: 1608 EEAERRAQQQAEAERAREEAERELERWQLKANEALR-LRLQAEEVAQQKSLAQAEAEKQK 1666

Query: 320  LEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLE 379
             E  R+ RR+ K  + Q   Q E+    L+ + +++   A      +   ++       E
Sbjct: 1667 EEAEREARRRGKAEE-QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ--ELIRLRAETE 1723

Query: 380  QAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILL----QKDYESASLT 435
            Q E+   + L  E+ RL+R    A + RQ+          + ++LL    + + ES S +
Sbjct: 1724 QGEQ-QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1782

Query: 436  EVRALLRKHEAFE-SDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKI-CDQWDRL 493
            E      + EA    +LA    R+  +A  A+   +L   DA       +++  ++   +
Sbjct: 1783 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1842

Query: 494  GTLTQKRREAL----------ERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMF 543
            G  T+ + EA           ER+ +L E          ++AA     +E  +  L+   
Sbjct: 1843 GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 1902

Query: 544  IVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVT 603
                +E  + L+      + TL +     + I+A++   EK                +  
Sbjct: 1903 D-SELERQKGLV------EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1955

Query: 604  MDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNK--MEEIA 661
             D LR+K     +    R  + +EE  R+ A ER+++  AA+  A     Q K  +EE+ 
Sbjct: 1956 EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR---QRKAALEEVE 2012

Query: 662  RSSIQITGA 670
            R   ++  A
Sbjct: 2013 RLKAKVEEA 2021



 Score = 37.0 bits (84), Expect = 0.082
 Identities = 79/379 (20%), Positives = 151/379 (39%), Gaps = 32/379 (8%)

Query: 265  AANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFR 324
            A NR   +   +     L EE E++     E  R ++   E     +  +    +     
Sbjct: 2249 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALA 2308

Query: 325  DYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKG 384
            +   K K   VQE  +L+     LQ +  ++   A    E K    +A   Q+L +  +G
Sbjct: 2309 EKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDK--EQMA---QQLAEETQG 2363

Query: 385  YEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYES--ASLTEVRALLR 442
            ++  L  E  R  +LE  AE  R K    E     + Q   ++D +       E+   L 
Sbjct: 2364 FQRTL--EAERQRQLEMSAEAERLKLRVAEM---SRAQARAEEDAQRFRKQAEEIGEKLH 2418

Query: 443  KHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRRE 502
            + E       A Q++V  +  +  +  + D HDA  + +   ++  + ++L    Q+  +
Sbjct: 2419 RTEL------ATQEKVTLVQTLEIQRQQSD-HDAERLREAIAELEREKEKL----QQEAK 2467

Query: 503  ALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFK 562
             L+   + ++T+ Q  L    +A   +   E      ++ FI     +++ L      F+
Sbjct: 2468 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL------FQ 2521

Query: 563  ATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRD 622
              + +A   R+     Q ++E+  Q     +  +        + +R K ++++QL   R 
Sbjct: 2522 DEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRR 2581

Query: 623  QSLQEELARQHANERLRRQ 641
            Q  QEEL  +  N+RLR Q
Sbjct: 2582 Q--QEELLAEE-NQRLREQ 2597



 Score = 34.3 bits (77), Expect = 0.53
 Identities = 56/264 (21%), Positives = 105/264 (39%), Gaps = 61/264 (23%)

Query: 434  LTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQ--WD 491
            L  +  ++R  +  E  L AH++++++  A+   L EL+   A     R Q    Q  +D
Sbjct: 1088 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1147

Query: 492  RLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEI 551
             L       R+ L   +++ E + Q H    +R      W E   + L            
Sbjct: 1148 AL-------RDELRGAQEVGERLQQRH---GERDVEVERWRERVAQLL------------ 1185

Query: 552  QSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKW 611
                   E+++A L + D         Q E+E++ +       S++P      D  R + 
Sbjct: 1186 -------ERWQAVLAQTD-------VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ- 1230

Query: 612  DKVKQLVPIRD-QSLQEELARQHA-NERLRRQFAAQANAIGPWIQNKMEEIARSSIQITG 669
             +  Q +P+ D Q+++E+L ++ A  E + R               K+EE  R + Q   
Sbjct: 1231 -EQIQAMPLADSQAVREQLRQEQALLEEIERH------------GEKVEECQRFAKQ--- 1274

Query: 670  ALEDQMNQLKQYEHNIINYKNNID 693
                 +N +K YE  ++ YK  ++
Sbjct: 1275 ----YINAIKDYELQLVTYKAQLE 1294



 Score = 32.7 bits (73), Expect = 1.5
 Identities = 78/425 (18%), Positives = 163/425 (38%), Gaps = 63/425 (14%)

Query: 281  RLMEEYERLASELLEWIR---------RTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHK 331
            R +  Y   A  L  W++         + +P  +++   + ++  Q  LE+   +  K  
Sbjct: 1207 RQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK-- 1264

Query: 332  PPKVQEKCQ------------LEINFNTLQTKLRISNRPAFMP-----SEGKMVS--DIA 372
                 E+CQ             E+   T + +L     PA  P     SE  +    D+ 
Sbjct: 1265 ----VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLR 1320

Query: 373  GAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESA 432
              +  L      Y +++   +RR+E  E LAE  +Q+A   E  A  +  +  Q+    A
Sbjct: 1321 THYSELTTLTSQYIKFISETLRRMEEEERLAE--QQRAEERERLAEVEAALEKQRQLAEA 1378

Query: 433  SLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDR 492
                     R+ +  +  +     R E+ A  AQ+          ++ +  Q++    + 
Sbjct: 1379 HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKR-------SIQEELQQLRQSSEA 1431

Query: 493  LGTLTQKRREALERMEKLLE---TIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIE 549
                  ++ EA ER    +E    + +L LE  +R        EG ++ L+        +
Sbjct: 1432 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ---RGGAEGELQALRARAEEAEAQ 1488

Query: 550  EIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRT 609
            + Q+   A    +    E+  +RQ+ + + + V+   ++     +     +   ++ELR 
Sbjct: 1489 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEA-----AREKQRALQALEELRL 1543

Query: 610  KWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITG 669
            + ++ ++    R +  + E ARQ        Q +A+A      +Q+K    A  + Q+  
Sbjct: 1544 QAEEAER----RLRQAEVERARQVQVALETAQRSAEAE-----LQSKRASFAEKTAQLER 1594

Query: 670  ALEDQ 674
            +L+++
Sbjct: 1595 SLQEE 1599


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score =  239 bits (611), Expect = 6e-63
 Identities = 186/630 (29%), Positives = 298/630 (47%), Gaps = 39/630 (6%)

Query: 37  EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPKPDRGKMRFHK 96
           ++ Q+KTFT W N HL KA   I ++ ED R+G  L+ LLEV+SG+ LP+ ++G+MRFHK
Sbjct: 45  DRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFHK 103

Query: 97  IANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISV----EETS 152
           + NV  ALDY+  + VKLV+I  ++I DGN K+TLG+IWTIIL F I DI V    E+ +
Sbjct: 104 LQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMT 163

Query: 153 AKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPDLIDYSKLNKDDPIGNI 212
           AKE LLLW QR    Y+ +   NF +SW+DG    A+IHRH+P LID +K+ +   + N+
Sbjct: 164 AKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENL 223

Query: 213 NLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQAETAANRICKV 272
           + A  +AE+ L + ++LD ED V+ P+PDE++I+TYVS  Y A       +         
Sbjct: 224 DQAFSVAERDLGVTRLLDPED-VDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRA---- 278

Query: 273 LAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHKP 332
                E +   +EY  L   LL+W+R      E R    + + ++     F  ++    P
Sbjct: 279 ----NELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELP 334

Query: 333 PKVQEKCQLEINFNTLQTKL---RISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWL 389
            K  +K + +  + +L+  +   ++   P + P       D+   W +L  A    E+ L
Sbjct: 335 AKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHP------LDVEKEWGKLHVAILEREKQL 388

Query: 390 LNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFES 449
            +E  RLE L+ +  K + +A   E     +   LLQ D    +  +V    ++    E 
Sbjct: 389 RSEFERLECLQRIVTKLQMEAGLCEE-QLNQADALLQSDVRLLAAGKVP---QRAGEVER 444

Query: 450 DLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEK 509
           DL      +  +    Q L +  +     +  R  ++ ++   + T    R +A   +  
Sbjct: 445 DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKA--GVAA 502

Query: 510 LLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEAD 569
               + Q+ L+  +R        +  +  LQD  ++  +EE Q  +   E +   LP  +
Sbjct: 503 PATQVAQVTLQSVQRRPELE---DSTLRYLQD--LLAWVEENQHRVDGAE-WGVDLPSVE 556

Query: 570 GERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQEEL 629
            +  S   +   +E+         S     S  T    R   D + +L     + L    
Sbjct: 557 AQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYR---DCLGRLDLQYAKLLNSSK 613

Query: 630 ARQHANERLRRQFAAQANAIGPWIQNKMEE 659
           AR  + E L   F A A     W+  K EE
Sbjct: 614 ARLRSLESL-HSFVAAATKELMWLNEKEEE 642



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 102/559 (18%), Positives = 213/559 (38%), Gaps = 61/559 (10%)

Query: 212  INLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQAETAANRI-- 269
            + LA E A+K L   +   A  +    +  ++ +    S        AE A  AA     
Sbjct: 2040 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2099

Query: 270  CKVLAVNQ--ENERLMEEYERL-------------ASELLEWIRRTIPWLENRTPEKTMQ 314
             +V A  +  ++ R +EE ERL             A    E +R+       R  +    
Sbjct: 2100 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA 2159

Query: 315  AMQKK--LEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIA 372
            A+++K   +   +  +K     +++K Q+E    TL+ +L  ++    +  E ++    A
Sbjct: 2160 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE-ELQRLKA 2218

Query: 373  GAWQRLEQAEKGYEEWL-----LNEIRRLER--------------------LEHLAEKFR 407
             A +   Q  +  EE       + E+ +L+                     L+  AEK +
Sbjct: 2219 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2278

Query: 408  QKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQE 467
            Q A      +   ++    +      L + RAL  K    +        R++  A + Q+
Sbjct: 2279 QVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2338

Query: 468  LNELDYHDAVNVNDRCQKICDQWDR-----LGTLTQKRREAL------ERMEKLLETIDQ 516
              EL    A  + +  +++  Q          TL  +R+  L      ER++  +  + +
Sbjct: 2339 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2398

Query: 517  LHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIM 576
                  + A  F    E   E L    +  + E++  + T   Q + +  +A+  R++I 
Sbjct: 2399 AQARAEEDAQRFRKQAEEIGEKLHRTELA-TQEKVTLVQTLEIQRQQSDHDAERLREAIA 2457

Query: 577  AIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQ-LVPIRDQSLQEELARQHAN 635
             ++ E EK+ Q   +    S    TV  ++L  +   ++Q  +  +D  LQ E   +   
Sbjct: 2458 ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK 2517

Query: 636  ERLRRQF---AAQANAIGPWIQNKMEEIARSSIQITGALEDQMNQLKQYEHNIINYKNNI 692
             +L + F    A+A  +    Q + +++ +   ++  ++E+   +  + E  +   +  +
Sbjct: 2518 AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL 2577

Query: 693  DKLEGDHQLIQEALVFDNK 711
             +LE   +  +E L  +N+
Sbjct: 2578 QQLEQQRRQQEELLAEENQ 2596



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 91/429 (21%), Positives = 173/429 (40%), Gaps = 33/429 (7%)

Query: 260  EQAETAANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKK 319
            E+AE  A +  +     +E ER +E ++  A+E L  +R     +  +      +A ++K
Sbjct: 1612 EEAERRAQQQAEAERAREEAERELERWQLKANEALR-LRLQAEEVAQQKSLAQAEAEKQK 1670

Query: 320  LEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLE 379
             E  R+ RR+ K  + Q   Q E+    L+ + +++   A      +   ++       E
Sbjct: 1671 EEAEREARRRGKAEE-QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ--ELIRLRAETE 1727

Query: 380  QAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILL----QKDYESASLT 435
            Q E+   + L  E+ RL+R    A + RQ+          + ++LL    + + ES S +
Sbjct: 1728 QGEQ-QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1786

Query: 436  EVRALLRKHEAFE-SDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKI-CDQWDRL 493
            E      + EA    +LA    R+  +A  A+   +L   DA       +++  ++   +
Sbjct: 1787 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1846

Query: 494  GTLTQKRREAL----------ERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMF 543
            G  T+ + EA           ER+ +L E          ++AA     +E  +  L+   
Sbjct: 1847 GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 1906

Query: 544  IVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVT 603
                +E  + L+      + TL +     + I+A++   EK                +  
Sbjct: 1907 D-SELERQKGLV------EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1959

Query: 604  MDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNK--MEEIA 661
             D LR+K     +    R  + +EE  R+ A ER+++  AA+  A     Q K  +EE+ 
Sbjct: 1960 EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR---QRKAALEEVE 2016

Query: 662  RSSIQITGA 670
            R   ++  A
Sbjct: 2017 RLKAKVEEA 2025



 Score = 37.0 bits (84), Expect = 0.082
 Identities = 79/379 (20%), Positives = 151/379 (39%), Gaps = 32/379 (8%)

Query: 265  AANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFR 324
            A NR   +   +     L EE E++     E  R ++   E     +  +    +     
Sbjct: 2253 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALA 2312

Query: 325  DYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKG 384
            +   K K   VQE  +L+     LQ +  ++   A    E K    +A   Q+L +  +G
Sbjct: 2313 EKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDK--EQMA---QQLAEETQG 2367

Query: 385  YEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYES--ASLTEVRALLR 442
            ++  L  E  R  +LE  AE  R K    E     + Q   ++D +       E+   L 
Sbjct: 2368 FQRTL--EAERQRQLEMSAEAERLKLRVAEM---SRAQARAEEDAQRFRKQAEEIGEKLH 2422

Query: 443  KHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRRE 502
            + E       A Q++V  +  +  +  + D HDA  + +   ++  + ++L    Q+  +
Sbjct: 2423 RTEL------ATQEKVTLVQTLEIQRQQSD-HDAERLREAIAELEREKEKL----QQEAK 2471

Query: 503  ALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFK 562
             L+   + ++T+ Q  L    +A   +   E      ++ FI     +++ L      F+
Sbjct: 2472 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL------FQ 2525

Query: 563  ATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRD 622
              + +A   R+     Q ++E+  Q     +  +        + +R K ++++QL   R 
Sbjct: 2526 DEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRR 2585

Query: 623  QSLQEELARQHANERLRRQ 641
            Q  QEEL  +  N+RLR Q
Sbjct: 2586 Q--QEELLAEE-NQRLREQ 2601



 Score = 34.3 bits (77), Expect = 0.53
 Identities = 56/264 (21%), Positives = 105/264 (39%), Gaps = 61/264 (23%)

Query: 434  LTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQ--WD 491
            L  +  ++R  +  E  L AH++++++  A+   L EL+   A     R Q    Q  +D
Sbjct: 1092 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1151

Query: 492  RLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEI 551
             L       R+ L   +++ E + Q H    +R      W E   + L            
Sbjct: 1152 AL-------RDELRGAQEVGERLQQRH---GERDVEVERWRERVAQLL------------ 1189

Query: 552  QSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKW 611
                   E+++A L + D         Q E+E++ +       S++P      D  R + 
Sbjct: 1190 -------ERWQAVLAQTD-------VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ- 1234

Query: 612  DKVKQLVPIRD-QSLQEELARQHA-NERLRRQFAAQANAIGPWIQNKMEEIARSSIQITG 669
             +  Q +P+ D Q+++E+L ++ A  E + R               K+EE  R + Q   
Sbjct: 1235 -EQIQAMPLADSQAVREQLRQEQALLEEIERH------------GEKVEECQRFAKQ--- 1278

Query: 670  ALEDQMNQLKQYEHNIINYKNNID 693
                 +N +K YE  ++ YK  ++
Sbjct: 1279 ----YINAIKDYELQLVTYKAQLE 1298



 Score = 32.7 bits (73), Expect = 1.5
 Identities = 78/425 (18%), Positives = 163/425 (38%), Gaps = 63/425 (14%)

Query: 281  RLMEEYERLASELLEWIR---------RTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHK 331
            R +  Y   A  L  W++         + +P  +++   + ++  Q  LE+   +  K  
Sbjct: 1211 RQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK-- 1268

Query: 332  PPKVQEKCQ------------LEINFNTLQTKLRISNRPAFMP-----SEGKMVS--DIA 372
                 E+CQ             E+   T + +L     PA  P     SE  +    D+ 
Sbjct: 1269 ----VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLR 1324

Query: 373  GAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESA 432
              +  L      Y +++   +RR+E  E LAE  +Q+A   E  A  +  +  Q+    A
Sbjct: 1325 THYSELTTLTSQYIKFISETLRRMEEEERLAE--QQRAEERERLAEVEAALEKQRQLAEA 1382

Query: 433  SLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDR 492
                     R+ +  +  +     R E+ A  AQ+          ++ +  Q++    + 
Sbjct: 1383 HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKR-------SIQEELQQLRQSSEA 1435

Query: 493  LGTLTQKRREALERMEKLLE---TIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIE 549
                  ++ EA ER    +E    + +L LE  +R        EG ++ L+        +
Sbjct: 1436 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ---RGGAEGELQALRARAEEAEAQ 1492

Query: 550  EIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRT 609
            + Q+   A    +    E+  +RQ+ + + + V+   ++     +     +   ++ELR 
Sbjct: 1493 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEA-----AREKQRALQALEELRL 1547

Query: 610  KWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITG 669
            + ++ ++    R +  + E ARQ        Q +A+A      +Q+K    A  + Q+  
Sbjct: 1548 QAEEAER----RLRQAEVERARQVQVALETAQRSAEAE-----LQSKRASFAEKTAQLER 1598

Query: 670  ALEDQ 674
            +L+++
Sbjct: 1599 SLQEE 1603


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score =  239 bits (611), Expect = 6e-63
 Identities = 186/630 (29%), Positives = 298/630 (47%), Gaps = 39/630 (6%)

Query: 37  EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPKPDRGKMRFHK 96
           ++ Q+KTFT W N HL KA   I ++ ED R+G  L+ LLEV+SG+ LP+ ++G+MRFHK
Sbjct: 9   DRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFHK 67

Query: 97  IANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISV----EETS 152
           + NV  ALDY+  + VKLV+I  ++I DGN K+TLG+IWTIIL F I DI V    E+ +
Sbjct: 68  LQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMT 127

Query: 153 AKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPDLIDYSKLNKDDPIGNI 212
           AKE LLLW QR    Y+ +   NF +SW+DG    A+IHRH+P LID +K+ +   + N+
Sbjct: 128 AKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENL 187

Query: 213 NLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQAETAANRICKV 272
           + A  +AE+ L + ++LD ED V+ P+PDE++I+TYVS  Y A       +         
Sbjct: 188 DQAFSVAERDLGVTRLLDPED-VDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRA---- 242

Query: 273 LAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHKP 332
                E +   +EY  L   LL+W+R      E R    + + ++     F  ++    P
Sbjct: 243 ----NELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELP 298

Query: 333 PKVQEKCQLEINFNTLQTKL---RISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWL 389
            K  +K + +  + +L+  +   ++   P + P       D+   W +L  A    E+ L
Sbjct: 299 AKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHP------LDVEKEWGKLHVAILEREKQL 352

Query: 390 LNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFES 449
            +E  RLE L+ +  K + +A   E     +   LLQ D    +  +V    ++    E 
Sbjct: 353 RSEFERLECLQRIVTKLQMEAGLCEE-QLNQADALLQSDVRLLAAGKVP---QRAGEVER 408

Query: 450 DLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEK 509
           DL      +  +    Q L +  +     +  R  ++ ++   + T    R +A   +  
Sbjct: 409 DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKA--GVAA 466

Query: 510 LLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEAD 569
               + Q+ L+  +R        +  +  LQD  ++  +EE Q  +   E +   LP  +
Sbjct: 467 PATQVAQVTLQSVQRRPELE---DSTLRYLQD--LLAWVEENQHRVDGAE-WGVDLPSVE 520

Query: 570 GERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQEEL 629
            +  S   +   +E+         S     S  T    R   D + +L     + L    
Sbjct: 521 AQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYR---DCLGRLDLQYAKLLNSSK 577

Query: 630 ARQHANERLRRQFAAQANAIGPWIQNKMEE 659
           AR  + E L   F A A     W+  K EE
Sbjct: 578 ARLRSLESL-HSFVAAATKELMWLNEKEEE 606



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 102/559 (18%), Positives = 213/559 (38%), Gaps = 61/559 (10%)

Query: 212  INLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQAETAANRI-- 269
            + LA E A+K L   +   A  +    +  ++ +    S        AE A  AA     
Sbjct: 2004 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2063

Query: 270  CKVLAVNQ--ENERLMEEYERL-------------ASELLEWIRRTIPWLENRTPEKTMQ 314
             +V A  +  ++ R +EE ERL             A    E +R+       R  +    
Sbjct: 2064 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA 2123

Query: 315  AMQKK--LEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIA 372
            A+++K   +   +  +K     +++K Q+E    TL+ +L  ++    +  E ++    A
Sbjct: 2124 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE-ELQRLKA 2182

Query: 373  GAWQRLEQAEKGYEEWL-----LNEIRRLER--------------------LEHLAEKFR 407
             A +   Q  +  EE       + E+ +L+                     L+  AEK +
Sbjct: 2183 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2242

Query: 408  QKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQE 467
            Q A      +   ++    +      L + RAL  K    +        R++  A + Q+
Sbjct: 2243 QVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2302

Query: 468  LNELDYHDAVNVNDRCQKICDQWDR-----LGTLTQKRREAL------ERMEKLLETIDQ 516
              EL    A  + +  +++  Q          TL  +R+  L      ER++  +  + +
Sbjct: 2303 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2362

Query: 517  LHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIM 576
                  + A  F    E   E L    +  + E++  + T   Q + +  +A+  R++I 
Sbjct: 2363 AQARAEEDAQRFRKQAEEIGEKLHRTELA-TQEKVTLVQTLEIQRQQSDHDAERLREAIA 2421

Query: 577  AIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQ-LVPIRDQSLQEELARQHAN 635
             ++ E EK+ Q   +    S    TV  ++L  +   ++Q  +  +D  LQ E   +   
Sbjct: 2422 ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK 2481

Query: 636  ERLRRQF---AAQANAIGPWIQNKMEEIARSSIQITGALEDQMNQLKQYEHNIINYKNNI 692
             +L + F    A+A  +    Q + +++ +   ++  ++E+   +  + E  +   +  +
Sbjct: 2482 AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL 2541

Query: 693  DKLEGDHQLIQEALVFDNK 711
             +LE   +  +E L  +N+
Sbjct: 2542 QQLEQQRRQQEELLAEENQ 2560



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 91/429 (21%), Positives = 173/429 (40%), Gaps = 33/429 (7%)

Query: 260  EQAETAANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKK 319
            E+AE  A +  +     +E ER +E ++  A+E L  +R     +  +      +A ++K
Sbjct: 1576 EEAERRAQQQAEAERAREEAERELERWQLKANEALR-LRLQAEEVAQQKSLAQAEAEKQK 1634

Query: 320  LEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLE 379
             E  R+ RR+ K  + Q   Q E+    L+ + +++   A      +   ++       E
Sbjct: 1635 EEAEREARRRGKAEE-QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ--ELIRLRAETE 1691

Query: 380  QAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILL----QKDYESASLT 435
            Q E+   + L  E+ RL+R    A + RQ+          + ++LL    + + ES S +
Sbjct: 1692 QGEQ-QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1750

Query: 436  EVRALLRKHEAFE-SDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKI-CDQWDRL 493
            E      + EA    +LA    R+  +A  A+   +L   DA       +++  ++   +
Sbjct: 1751 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1810

Query: 494  GTLTQKRREAL----------ERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMF 543
            G  T+ + EA           ER+ +L E          ++AA     +E  +  L+   
Sbjct: 1811 GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 1870

Query: 544  IVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVT 603
                +E  + L+      + TL +     + I+A++   EK                +  
Sbjct: 1871 D-SELERQKGLV------EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1923

Query: 604  MDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNK--MEEIA 661
             D LR+K     +    R  + +EE  R+ A ER+++  AA+  A     Q K  +EE+ 
Sbjct: 1924 EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR---QRKAALEEVE 1980

Query: 662  RSSIQITGA 670
            R   ++  A
Sbjct: 1981 RLKAKVEEA 1989



 Score = 37.0 bits (84), Expect = 0.082
 Identities = 79/379 (20%), Positives = 151/379 (39%), Gaps = 32/379 (8%)

Query: 265  AANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFR 324
            A NR   +   +     L EE E++     E  R ++   E     +  +    +     
Sbjct: 2217 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALA 2276

Query: 325  DYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKG 384
            +   K K   VQE  +L+     LQ +  ++   A    E K    +A   Q+L +  +G
Sbjct: 2277 EKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDK--EQMA---QQLAEETQG 2331

Query: 385  YEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYES--ASLTEVRALLR 442
            ++  L  E  R  +LE  AE  R K    E     + Q   ++D +       E+   L 
Sbjct: 2332 FQRTL--EAERQRQLEMSAEAERLKLRVAEM---SRAQARAEEDAQRFRKQAEEIGEKLH 2386

Query: 443  KHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRRE 502
            + E       A Q++V  +  +  +  + D HDA  + +   ++  + ++L    Q+  +
Sbjct: 2387 RTEL------ATQEKVTLVQTLEIQRQQSD-HDAERLREAIAELEREKEKL----QQEAK 2435

Query: 503  ALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFK 562
             L+   + ++T+ Q  L    +A   +   E      ++ FI     +++ L      F+
Sbjct: 2436 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL------FQ 2489

Query: 563  ATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRD 622
              + +A   R+     Q ++E+  Q     +  +        + +R K ++++QL   R 
Sbjct: 2490 DEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRR 2549

Query: 623  QSLQEELARQHANERLRRQ 641
            Q  QEEL  +  N+RLR Q
Sbjct: 2550 Q--QEELLAEE-NQRLREQ 2565



 Score = 34.3 bits (77), Expect = 0.53
 Identities = 56/264 (21%), Positives = 105/264 (39%), Gaps = 61/264 (23%)

Query: 434  LTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQ--WD 491
            L  +  ++R  +  E  L AH++++++  A+   L EL+   A     R Q    Q  +D
Sbjct: 1056 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1115

Query: 492  RLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEI 551
             L       R+ L   +++ E + Q H    +R      W E   + L            
Sbjct: 1116 AL-------RDELRGAQEVGERLQQRH---GERDVEVERWRERVAQLL------------ 1153

Query: 552  QSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKW 611
                   E+++A L + D         Q E+E++ +       S++P      D  R + 
Sbjct: 1154 -------ERWQAVLAQTD-------VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ- 1198

Query: 612  DKVKQLVPIRD-QSLQEELARQHA-NERLRRQFAAQANAIGPWIQNKMEEIARSSIQITG 669
             +  Q +P+ D Q+++E+L ++ A  E + R               K+EE  R + Q   
Sbjct: 1199 -EQIQAMPLADSQAVREQLRQEQALLEEIERH------------GEKVEECQRFAKQ--- 1242

Query: 670  ALEDQMNQLKQYEHNIINYKNNID 693
                 +N +K YE  ++ YK  ++
Sbjct: 1243 ----YINAIKDYELQLVTYKAQLE 1262



 Score = 32.7 bits (73), Expect = 1.5
 Identities = 78/425 (18%), Positives = 163/425 (38%), Gaps = 63/425 (14%)

Query: 281  RLMEEYERLASELLEWIR---------RTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHK 331
            R +  Y   A  L  W++         + +P  +++   + ++  Q  LE+   +  K  
Sbjct: 1175 RQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK-- 1232

Query: 332  PPKVQEKCQ------------LEINFNTLQTKLRISNRPAFMP-----SEGKMVS--DIA 372
                 E+CQ             E+   T + +L     PA  P     SE  +    D+ 
Sbjct: 1233 ----VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLR 1288

Query: 373  GAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESA 432
              +  L      Y +++   +RR+E  E LAE  +Q+A   E  A  +  +  Q+    A
Sbjct: 1289 THYSELTTLTSQYIKFISETLRRMEEEERLAE--QQRAEERERLAEVEAALEKQRQLAEA 1346

Query: 433  SLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDR 492
                     R+ +  +  +     R E+ A  AQ+          ++ +  Q++    + 
Sbjct: 1347 HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKR-------SIQEELQQLRQSSEA 1399

Query: 493  LGTLTQKRREALERMEKLLE---TIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIE 549
                  ++ EA ER    +E    + +L LE  +R        EG ++ L+        +
Sbjct: 1400 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ---RGGAEGELQALRARAEEAEAQ 1456

Query: 550  EIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRT 609
            + Q+   A    +    E+  +RQ+ + + + V+   ++     +     +   ++ELR 
Sbjct: 1457 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEA-----AREKQRALQALEELRL 1511

Query: 610  KWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITG 669
            + ++ ++    R +  + E ARQ        Q +A+A      +Q+K    A  + Q+  
Sbjct: 1512 QAEEAER----RLRQAEVERARQVQVALETAQRSAEAE-----LQSKRASFAEKTAQLER 1562

Query: 670  ALEDQ 674
            +L+++
Sbjct: 1563 SLQEE 1567


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score =  239 bits (611), Expect = 6e-63
 Identities = 186/630 (29%), Positives = 298/630 (47%), Gaps = 39/630 (6%)

Query: 37  EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPKPDRGKMRFHK 96
           ++ Q+KTFT W N HL KA   I ++ ED R+G  L+ LLEV+SG+ LP+ ++G+MRFHK
Sbjct: 178 DRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFHK 236

Query: 97  IANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISV----EETS 152
           + NV  ALDY+  + VKLV+I  ++I DGN K+TLG+IWTIIL F I DI V    E+ +
Sbjct: 237 LQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMT 296

Query: 153 AKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPDLIDYSKLNKDDPIGNI 212
           AKE LLLW QR    Y+ +   NF +SW+DG    A+IHRH+P LID +K+ +   + N+
Sbjct: 297 AKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENL 356

Query: 213 NLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQAETAANRICKV 272
           + A  +AE+ L + ++LD ED V+ P+PDE++I+TYVS  Y A       +         
Sbjct: 357 DQAFSVAERDLGVTRLLDPED-VDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRA---- 411

Query: 273 LAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHKP 332
                E +   +EY  L   LL+W+R      E R    + + ++     F  ++    P
Sbjct: 412 ----NELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELP 467

Query: 333 PKVQEKCQLEINFNTLQTKL---RISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWL 389
            K  +K + +  + +L+  +   ++   P + P       D+   W +L  A    E+ L
Sbjct: 468 AKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHP------LDVEKEWGKLHVAILEREKQL 521

Query: 390 LNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFES 449
            +E  RLE L+ +  K + +A   E     +   LLQ D    +  +V    ++    E 
Sbjct: 522 RSEFERLECLQRIVTKLQMEAGLCEE-QLNQADALLQSDVRLLAAGKVP---QRAGEVER 577

Query: 450 DLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEK 509
           DL      +  +    Q L +  +     +  R  ++ ++   + T    R +A   +  
Sbjct: 578 DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKA--GVAA 635

Query: 510 LLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEAD 569
               + Q+ L+  +R        +  +  LQD  ++  +EE Q  +   E +   LP  +
Sbjct: 636 PATQVAQVTLQSVQRRPELE---DSTLRYLQD--LLAWVEENQHRVDGAE-WGVDLPSVE 689

Query: 570 GERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQEEL 629
            +  S   +   +E+         S     S  T    R   D + +L     + L    
Sbjct: 690 AQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYR---DCLGRLDLQYAKLLNSSK 746

Query: 630 ARQHANERLRRQFAAQANAIGPWIQNKMEE 659
           AR  + E L   F A A     W+  K EE
Sbjct: 747 ARLRSLESL-HSFVAAATKELMWLNEKEEE 775



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 102/559 (18%), Positives = 213/559 (38%), Gaps = 61/559 (10%)

Query: 212  INLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQAETAANRI-- 269
            + LA E A+K L   +   A  +    +  ++ +    S        AE A  AA     
Sbjct: 2173 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2232

Query: 270  CKVLAVNQ--ENERLMEEYERL-------------ASELLEWIRRTIPWLENRTPEKTMQ 314
             +V A  +  ++ R +EE ERL             A    E +R+       R  +    
Sbjct: 2233 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA 2292

Query: 315  AMQKK--LEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIA 372
            A+++K   +   +  +K     +++K Q+E    TL+ +L  ++    +  E ++    A
Sbjct: 2293 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE-ELQRLKA 2351

Query: 373  GAWQRLEQAEKGYEEWL-----LNEIRRLER--------------------LEHLAEKFR 407
             A +   Q  +  EE       + E+ +L+                     L+  AEK +
Sbjct: 2352 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2411

Query: 408  QKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQE 467
            Q A      +   ++    +      L + RAL  K    +        R++  A + Q+
Sbjct: 2412 QVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2471

Query: 468  LNELDYHDAVNVNDRCQKICDQWDR-----LGTLTQKRREAL------ERMEKLLETIDQ 516
              EL    A  + +  +++  Q          TL  +R+  L      ER++  +  + +
Sbjct: 2472 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2531

Query: 517  LHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIM 576
                  + A  F    E   E L    +  + E++  + T   Q + +  +A+  R++I 
Sbjct: 2532 AQARAEEDAQRFRKQAEEIGEKLHRTELA-TQEKVTLVQTLEIQRQQSDHDAERLREAIA 2590

Query: 577  AIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQ-LVPIRDQSLQEELARQHAN 635
             ++ E EK+ Q   +    S    TV  ++L  +   ++Q  +  +D  LQ E   +   
Sbjct: 2591 ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK 2650

Query: 636  ERLRRQF---AAQANAIGPWIQNKMEEIARSSIQITGALEDQMNQLKQYEHNIINYKNNI 692
             +L + F    A+A  +    Q + +++ +   ++  ++E+   +  + E  +   +  +
Sbjct: 2651 AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL 2710

Query: 693  DKLEGDHQLIQEALVFDNK 711
             +LE   +  +E L  +N+
Sbjct: 2711 QQLEQQRRQQEELLAEENQ 2729



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 91/429 (21%), Positives = 173/429 (40%), Gaps = 33/429 (7%)

Query: 260  EQAETAANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKK 319
            E+AE  A +  +     +E ER +E ++  A+E L  +R     +  +      +A ++K
Sbjct: 1745 EEAERRAQQQAEAERAREEAERELERWQLKANEALR-LRLQAEEVAQQKSLAQAEAEKQK 1803

Query: 320  LEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLE 379
             E  R+ RR+ K  + Q   Q E+    L+ + +++   A      +   ++       E
Sbjct: 1804 EEAEREARRRGKAEE-QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ--ELIRLRAETE 1860

Query: 380  QAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILL----QKDYESASLT 435
            Q E+   + L  E+ RL+R    A + RQ+          + ++LL    + + ES S +
Sbjct: 1861 QGEQ-QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1919

Query: 436  EVRALLRKHEAFE-SDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKI-CDQWDRL 493
            E      + EA    +LA    R+  +A  A+   +L   DA       +++  ++   +
Sbjct: 1920 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1979

Query: 494  GTLTQKRREAL----------ERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMF 543
            G  T+ + EA           ER+ +L E          ++AA     +E  +  L+   
Sbjct: 1980 GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 2039

Query: 544  IVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVT 603
                +E  + L+      + TL +     + I+A++   EK                +  
Sbjct: 2040 D-SELERQKGLV------EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 2092

Query: 604  MDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNK--MEEIA 661
             D LR+K     +    R  + +EE  R+ A ER+++  AA+  A     Q K  +EE+ 
Sbjct: 2093 EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR---QRKAALEEVE 2149

Query: 662  RSSIQITGA 670
            R   ++  A
Sbjct: 2150 RLKAKVEEA 2158



 Score = 37.0 bits (84), Expect = 0.082
 Identities = 79/379 (20%), Positives = 151/379 (39%), Gaps = 32/379 (8%)

Query: 265  AANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFR 324
            A NR   +   +     L EE E++     E  R ++   E     +  +    +     
Sbjct: 2386 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALA 2445

Query: 325  DYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKG 384
            +   K K   VQE  +L+     LQ +  ++   A    E K    +A   Q+L +  +G
Sbjct: 2446 EKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDK--EQMA---QQLAEETQG 2500

Query: 385  YEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYES--ASLTEVRALLR 442
            ++  L  E  R  +LE  AE  R K    E     + Q   ++D +       E+   L 
Sbjct: 2501 FQRTL--EAERQRQLEMSAEAERLKLRVAEM---SRAQARAEEDAQRFRKQAEEIGEKLH 2555

Query: 443  KHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRRE 502
            + E       A Q++V  +  +  +  + D HDA  + +   ++  + ++L    Q+  +
Sbjct: 2556 RTEL------ATQEKVTLVQTLEIQRQQSD-HDAERLREAIAELEREKEKL----QQEAK 2604

Query: 503  ALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFK 562
             L+   + ++T+ Q  L    +A   +   E      ++ FI     +++ L      F+
Sbjct: 2605 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL------FQ 2658

Query: 563  ATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRD 622
              + +A   R+     Q ++E+  Q     +  +        + +R K ++++QL   R 
Sbjct: 2659 DEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRR 2718

Query: 623  QSLQEELARQHANERLRRQ 641
            Q  QEEL  +  N+RLR Q
Sbjct: 2719 Q--QEELLAEE-NQRLREQ 2734



 Score = 34.3 bits (77), Expect = 0.53
 Identities = 56/264 (21%), Positives = 105/264 (39%), Gaps = 61/264 (23%)

Query: 434  LTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQ--WD 491
            L  +  ++R  +  E  L AH++++++  A+   L EL+   A     R Q    Q  +D
Sbjct: 1225 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1284

Query: 492  RLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEI 551
             L       R+ L   +++ E + Q H    +R      W E   + L            
Sbjct: 1285 AL-------RDELRGAQEVGERLQQRH---GERDVEVERWRERVAQLL------------ 1322

Query: 552  QSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKW 611
                   E+++A L + D         Q E+E++ +       S++P      D  R + 
Sbjct: 1323 -------ERWQAVLAQTD-------VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ- 1367

Query: 612  DKVKQLVPIRD-QSLQEELARQHA-NERLRRQFAAQANAIGPWIQNKMEEIARSSIQITG 669
             +  Q +P+ D Q+++E+L ++ A  E + R               K+EE  R + Q   
Sbjct: 1368 -EQIQAMPLADSQAVREQLRQEQALLEEIERH------------GEKVEECQRFAKQ--- 1411

Query: 670  ALEDQMNQLKQYEHNIINYKNNID 693
                 +N +K YE  ++ YK  ++
Sbjct: 1412 ----YINAIKDYELQLVTYKAQLE 1431



 Score = 32.7 bits (73), Expect = 1.5
 Identities = 78/425 (18%), Positives = 163/425 (38%), Gaps = 63/425 (14%)

Query: 281  RLMEEYERLASELLEWIR---------RTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHK 331
            R +  Y   A  L  W++         + +P  +++   + ++  Q  LE+   +  K  
Sbjct: 1344 RQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK-- 1401

Query: 332  PPKVQEKCQ------------LEINFNTLQTKLRISNRPAFMP-----SEGKMVS--DIA 372
                 E+CQ             E+   T + +L     PA  P     SE  +    D+ 
Sbjct: 1402 ----VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLR 1457

Query: 373  GAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESA 432
              +  L      Y +++   +RR+E  E LAE  +Q+A   E  A  +  +  Q+    A
Sbjct: 1458 THYSELTTLTSQYIKFISETLRRMEEEERLAE--QQRAEERERLAEVEAALEKQRQLAEA 1515

Query: 433  SLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDR 492
                     R+ +  +  +     R E+ A  AQ+          ++ +  Q++    + 
Sbjct: 1516 HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKR-------SIQEELQQLRQSSEA 1568

Query: 493  LGTLTQKRREALERMEKLLE---TIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIE 549
                  ++ EA ER    +E    + +L LE  +R        EG ++ L+        +
Sbjct: 1569 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ---RGGAEGELQALRARAEEAEAQ 1625

Query: 550  EIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRT 609
            + Q+   A    +    E+  +RQ+ + + + V+   ++     +     +   ++ELR 
Sbjct: 1626 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEA-----AREKQRALQALEELRL 1680

Query: 610  KWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITG 669
            + ++ ++    R +  + E ARQ        Q +A+A      +Q+K    A  + Q+  
Sbjct: 1681 QAEEAER----RLRQAEVERARQVQVALETAQRSAEAE-----LQSKRASFAEKTAQLER 1731

Query: 670  ALEDQ 674
            +L+++
Sbjct: 1732 SLQEE 1736


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score =  239 bits (611), Expect = 6e-63
 Identities = 186/630 (29%), Positives = 298/630 (47%), Gaps = 39/630 (6%)

Query: 37  EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPKPDRGKMRFHK 96
           ++ Q+KTFT W N HL KA   I ++ ED R+G  L+ LLEV+SG+ LP+ ++G+MRFHK
Sbjct: 19  DRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFHK 77

Query: 97  IANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISV----EETS 152
           + NV  ALDY+  + VKLV+I  ++I DGN K+TLG+IWTIIL F I DI V    E+ +
Sbjct: 78  LQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMT 137

Query: 153 AKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPDLIDYSKLNKDDPIGNI 212
           AKE LLLW QR    Y+ +   NF +SW+DG    A+IHRH+P LID +K+ +   + N+
Sbjct: 138 AKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENL 197

Query: 213 NLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQAETAANRICKV 272
           + A  +AE+ L + ++LD ED V+ P+PDE++I+TYVS  Y A       +         
Sbjct: 198 DQAFSVAERDLGVTRLLDPED-VDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRA---- 252

Query: 273 LAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHKP 332
                E +   +EY  L   LL+W+R      E R    + + ++     F  ++    P
Sbjct: 253 ----NELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELP 308

Query: 333 PKVQEKCQLEINFNTLQTKL---RISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWL 389
            K  +K + +  + +L+  +   ++   P + P       D+   W +L  A    E+ L
Sbjct: 309 AKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHP------LDVEKEWGKLHVAILEREKQL 362

Query: 390 LNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFES 449
            +E  RLE L+ +  K + +A   E     +   LLQ D    +  +V    ++    E 
Sbjct: 363 RSEFERLECLQRIVTKLQMEAGLCEE-QLNQADALLQSDVRLLAAGKVP---QRAGEVER 418

Query: 450 DLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEK 509
           DL      +  +    Q L +  +     +  R  ++ ++   + T    R +A   +  
Sbjct: 419 DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKA--GVAA 476

Query: 510 LLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEAD 569
               + Q+ L+  +R        +  +  LQD  ++  +EE Q  +   E +   LP  +
Sbjct: 477 PATQVAQVTLQSVQRRPELE---DSTLRYLQD--LLAWVEENQHRVDGAE-WGVDLPSVE 530

Query: 570 GERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQEEL 629
            +  S   +   +E+         S     S  T    R   D + +L     + L    
Sbjct: 531 AQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYR---DCLGRLDLQYAKLLNSSK 587

Query: 630 ARQHANERLRRQFAAQANAIGPWIQNKMEE 659
           AR  + E L   F A A     W+  K EE
Sbjct: 588 ARLRSLESL-HSFVAAATKELMWLNEKEEE 616



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 102/559 (18%), Positives = 213/559 (38%), Gaps = 61/559 (10%)

Query: 212  INLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQAETAANRI-- 269
            + LA E A+K L   +   A  +    +  ++ +    S        AE A  AA     
Sbjct: 2014 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2073

Query: 270  CKVLAVNQ--ENERLMEEYERL-------------ASELLEWIRRTIPWLENRTPEKTMQ 314
             +V A  +  ++ R +EE ERL             A    E +R+       R  +    
Sbjct: 2074 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA 2133

Query: 315  AMQKK--LEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIA 372
            A+++K   +   +  +K     +++K Q+E    TL+ +L  ++    +  E ++    A
Sbjct: 2134 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE-ELQRLKA 2192

Query: 373  GAWQRLEQAEKGYEEWL-----LNEIRRLER--------------------LEHLAEKFR 407
             A +   Q  +  EE       + E+ +L+                     L+  AEK +
Sbjct: 2193 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2252

Query: 408  QKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQE 467
            Q A      +   ++    +      L + RAL  K    +        R++  A + Q+
Sbjct: 2253 QVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2312

Query: 468  LNELDYHDAVNVNDRCQKICDQWDR-----LGTLTQKRREAL------ERMEKLLETIDQ 516
              EL    A  + +  +++  Q          TL  +R+  L      ER++  +  + +
Sbjct: 2313 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2372

Query: 517  LHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIM 576
                  + A  F    E   E L    +  + E++  + T   Q + +  +A+  R++I 
Sbjct: 2373 AQARAEEDAQRFRKQAEEIGEKLHRTELA-TQEKVTLVQTLEIQRQQSDHDAERLREAIA 2431

Query: 577  AIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQ-LVPIRDQSLQEELARQHAN 635
             ++ E EK+ Q   +    S    TV  ++L  +   ++Q  +  +D  LQ E   +   
Sbjct: 2432 ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK 2491

Query: 636  ERLRRQF---AAQANAIGPWIQNKMEEIARSSIQITGALEDQMNQLKQYEHNIINYKNNI 692
             +L + F    A+A  +    Q + +++ +   ++  ++E+   +  + E  +   +  +
Sbjct: 2492 AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL 2551

Query: 693  DKLEGDHQLIQEALVFDNK 711
             +LE   +  +E L  +N+
Sbjct: 2552 QQLEQQRRQQEELLAEENQ 2570



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 91/429 (21%), Positives = 173/429 (40%), Gaps = 33/429 (7%)

Query: 260  EQAETAANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKK 319
            E+AE  A +  +     +E ER +E ++  A+E L  +R     +  +      +A ++K
Sbjct: 1586 EEAERRAQQQAEAERAREEAERELERWQLKANEALR-LRLQAEEVAQQKSLAQAEAEKQK 1644

Query: 320  LEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLE 379
             E  R+ RR+ K  + Q   Q E+    L+ + +++   A      +   ++       E
Sbjct: 1645 EEAEREARRRGKAEE-QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ--ELIRLRAETE 1701

Query: 380  QAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILL----QKDYESASLT 435
            Q E+   + L  E+ RL+R    A + RQ+          + ++LL    + + ES S +
Sbjct: 1702 QGEQ-QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1760

Query: 436  EVRALLRKHEAFE-SDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKI-CDQWDRL 493
            E      + EA    +LA    R+  +A  A+   +L   DA       +++  ++   +
Sbjct: 1761 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1820

Query: 494  GTLTQKRREAL----------ERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMF 543
            G  T+ + EA           ER+ +L E          ++AA     +E  +  L+   
Sbjct: 1821 GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 1880

Query: 544  IVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVT 603
                +E  + L+      + TL +     + I+A++   EK                +  
Sbjct: 1881 D-SELERQKGLV------EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1933

Query: 604  MDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNK--MEEIA 661
             D LR+K     +    R  + +EE  R+ A ER+++  AA+  A     Q K  +EE+ 
Sbjct: 1934 EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR---QRKAALEEVE 1990

Query: 662  RSSIQITGA 670
            R   ++  A
Sbjct: 1991 RLKAKVEEA 1999



 Score = 37.0 bits (84), Expect = 0.082
 Identities = 79/379 (20%), Positives = 151/379 (39%), Gaps = 32/379 (8%)

Query: 265  AANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFR 324
            A NR   +   +     L EE E++     E  R ++   E     +  +    +     
Sbjct: 2227 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALA 2286

Query: 325  DYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKG 384
            +   K K   VQE  +L+     LQ +  ++   A    E K    +A   Q+L +  +G
Sbjct: 2287 EKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDK--EQMA---QQLAEETQG 2341

Query: 385  YEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYES--ASLTEVRALLR 442
            ++  L  E  R  +LE  AE  R K    E     + Q   ++D +       E+   L 
Sbjct: 2342 FQRTL--EAERQRQLEMSAEAERLKLRVAEM---SRAQARAEEDAQRFRKQAEEIGEKLH 2396

Query: 443  KHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRRE 502
            + E       A Q++V  +  +  +  + D HDA  + +   ++  + ++L    Q+  +
Sbjct: 2397 RTEL------ATQEKVTLVQTLEIQRQQSD-HDAERLREAIAELEREKEKL----QQEAK 2445

Query: 503  ALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFK 562
             L+   + ++T+ Q  L    +A   +   E      ++ FI     +++ L      F+
Sbjct: 2446 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL------FQ 2499

Query: 563  ATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRD 622
              + +A   R+     Q ++E+  Q     +  +        + +R K ++++QL   R 
Sbjct: 2500 DEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRR 2559

Query: 623  QSLQEELARQHANERLRRQ 641
            Q  QEEL  +  N+RLR Q
Sbjct: 2560 Q--QEELLAEE-NQRLREQ 2575



 Score = 34.3 bits (77), Expect = 0.53
 Identities = 56/264 (21%), Positives = 105/264 (39%), Gaps = 61/264 (23%)

Query: 434  LTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQ--WD 491
            L  +  ++R  +  E  L AH++++++  A+   L EL+   A     R Q    Q  +D
Sbjct: 1066 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1125

Query: 492  RLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEI 551
             L       R+ L   +++ E + Q H    +R      W E   + L            
Sbjct: 1126 AL-------RDELRGAQEVGERLQQRH---GERDVEVERWRERVAQLL------------ 1163

Query: 552  QSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKW 611
                   E+++A L + D         Q E+E++ +       S++P      D  R + 
Sbjct: 1164 -------ERWQAVLAQTD-------VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ- 1208

Query: 612  DKVKQLVPIRD-QSLQEELARQHA-NERLRRQFAAQANAIGPWIQNKMEEIARSSIQITG 669
             +  Q +P+ D Q+++E+L ++ A  E + R               K+EE  R + Q   
Sbjct: 1209 -EQIQAMPLADSQAVREQLRQEQALLEEIERH------------GEKVEECQRFAKQ--- 1252

Query: 670  ALEDQMNQLKQYEHNIINYKNNID 693
                 +N +K YE  ++ YK  ++
Sbjct: 1253 ----YINAIKDYELQLVTYKAQLE 1272



 Score = 32.7 bits (73), Expect = 1.5
 Identities = 78/425 (18%), Positives = 163/425 (38%), Gaps = 63/425 (14%)

Query: 281  RLMEEYERLASELLEWIR---------RTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHK 331
            R +  Y   A  L  W++         + +P  +++   + ++  Q  LE+   +  K  
Sbjct: 1185 RQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK-- 1242

Query: 332  PPKVQEKCQ------------LEINFNTLQTKLRISNRPAFMP-----SEGKMVS--DIA 372
                 E+CQ             E+   T + +L     PA  P     SE  +    D+ 
Sbjct: 1243 ----VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLR 1298

Query: 373  GAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESA 432
              +  L      Y +++   +RR+E  E LAE  +Q+A   E  A  +  +  Q+    A
Sbjct: 1299 THYSELTTLTSQYIKFISETLRRMEEEERLAE--QQRAEERERLAEVEAALEKQRQLAEA 1356

Query: 433  SLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDR 492
                     R+ +  +  +     R E+ A  AQ+          ++ +  Q++    + 
Sbjct: 1357 HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKR-------SIQEELQQLRQSSEA 1409

Query: 493  LGTLTQKRREALERMEKLLE---TIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIE 549
                  ++ EA ER    +E    + +L LE  +R        EG ++ L+        +
Sbjct: 1410 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ---RGGAEGELQALRARAEEAEAQ 1466

Query: 550  EIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRT 609
            + Q+   A    +    E+  +RQ+ + + + V+   ++     +     +   ++ELR 
Sbjct: 1467 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEA-----AREKQRALQALEELRL 1521

Query: 610  KWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITG 669
            + ++ ++    R +  + E ARQ        Q +A+A      +Q+K    A  + Q+  
Sbjct: 1522 QAEEAER----RLRQAEVERARQVQVALETAQRSAEAE-----LQSKRASFAEKTAQLER 1572

Query: 670  ALEDQ 674
            +L+++
Sbjct: 1573 SLQEE 1577


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score =  239 bits (611), Expect = 6e-63
 Identities = 186/630 (29%), Positives = 298/630 (47%), Gaps = 39/630 (6%)

Query: 37  EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPKPDRGKMRFHK 96
           ++ Q+KTFT W N HL KA   I ++ ED R+G  L+ LLEV+SG+ LP+ ++G+MRFHK
Sbjct: 68  DRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFHK 126

Query: 97  IANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISV----EETS 152
           + NV  ALDY+  + VKLV+I  ++I DGN K+TLG+IWTIIL F I DI V    E+ +
Sbjct: 127 LQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMT 186

Query: 153 AKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPDLIDYSKLNKDDPIGNI 212
           AKE LLLW QR    Y+ +   NF +SW+DG    A+IHRH+P LID +K+ +   + N+
Sbjct: 187 AKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENL 246

Query: 213 NLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQAETAANRICKV 272
           + A  +AE+ L + ++LD ED V+ P+PDE++I+TYVS  Y A       +         
Sbjct: 247 DQAFSVAERDLGVTRLLDPED-VDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRA---- 301

Query: 273 LAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHKP 332
                E +   +EY  L   LL+W+R      E R    + + ++     F  ++    P
Sbjct: 302 ----NELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELP 357

Query: 333 PKVQEKCQLEINFNTLQTKL---RISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWL 389
            K  +K + +  + +L+  +   ++   P + P       D+   W +L  A    E+ L
Sbjct: 358 AKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHP------LDVEKEWGKLHVAILEREKQL 411

Query: 390 LNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFES 449
            +E  RLE L+ +  K + +A   E     +   LLQ D    +  +V    ++    E 
Sbjct: 412 RSEFERLECLQRIVTKLQMEAGLCEE-QLNQADALLQSDVRLLAAGKVP---QRAGEVER 467

Query: 450 DLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEK 509
           DL      +  +    Q L +  +     +  R  ++ ++   + T    R +A   +  
Sbjct: 468 DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKA--GVAA 525

Query: 510 LLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEAD 569
               + Q+ L+  +R        +  +  LQD  ++  +EE Q  +   E +   LP  +
Sbjct: 526 PATQVAQVTLQSVQRRPELE---DSTLRYLQD--LLAWVEENQHRVDGAE-WGVDLPSVE 579

Query: 570 GERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQEEL 629
            +  S   +   +E+         S     S  T    R   D + +L     + L    
Sbjct: 580 AQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYR---DCLGRLDLQYAKLLNSSK 636

Query: 630 ARQHANERLRRQFAAQANAIGPWIQNKMEE 659
           AR  + E L   F A A     W+  K EE
Sbjct: 637 ARLRSLESL-HSFVAAATKELMWLNEKEEE 665



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 102/559 (18%), Positives = 213/559 (38%), Gaps = 61/559 (10%)

Query: 212  INLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQAETAANRI-- 269
            + LA E A+K L   +   A  +    +  ++ +    S        AE A  AA     
Sbjct: 2063 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2122

Query: 270  CKVLAVNQ--ENERLMEEYERL-------------ASELLEWIRRTIPWLENRTPEKTMQ 314
             +V A  +  ++ R +EE ERL             A    E +R+       R  +    
Sbjct: 2123 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA 2182

Query: 315  AMQKK--LEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIA 372
            A+++K   +   +  +K     +++K Q+E    TL+ +L  ++    +  E ++    A
Sbjct: 2183 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE-ELQRLKA 2241

Query: 373  GAWQRLEQAEKGYEEWL-----LNEIRRLER--------------------LEHLAEKFR 407
             A +   Q  +  EE       + E+ +L+                     L+  AEK +
Sbjct: 2242 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2301

Query: 408  QKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQE 467
            Q A      +   ++    +      L + RAL  K    +        R++  A + Q+
Sbjct: 2302 QVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2361

Query: 468  LNELDYHDAVNVNDRCQKICDQWDR-----LGTLTQKRREAL------ERMEKLLETIDQ 516
              EL    A  + +  +++  Q          TL  +R+  L      ER++  +  + +
Sbjct: 2362 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2421

Query: 517  LHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIM 576
                  + A  F    E   E L    +  + E++  + T   Q + +  +A+  R++I 
Sbjct: 2422 AQARAEEDAQRFRKQAEEIGEKLHRTELA-TQEKVTLVQTLEIQRQQSDHDAERLREAIA 2480

Query: 577  AIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQ-LVPIRDQSLQEELARQHAN 635
             ++ E EK+ Q   +    S    TV  ++L  +   ++Q  +  +D  LQ E   +   
Sbjct: 2481 ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK 2540

Query: 636  ERLRRQF---AAQANAIGPWIQNKMEEIARSSIQITGALEDQMNQLKQYEHNIINYKNNI 692
             +L + F    A+A  +    Q + +++ +   ++  ++E+   +  + E  +   +  +
Sbjct: 2541 AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL 2600

Query: 693  DKLEGDHQLIQEALVFDNK 711
             +LE   +  +E L  +N+
Sbjct: 2601 QQLEQQRRQQEELLAEENQ 2619



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 91/429 (21%), Positives = 173/429 (40%), Gaps = 33/429 (7%)

Query: 260  EQAETAANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKK 319
            E+AE  A +  +     +E ER +E ++  A+E L  +R     +  +      +A ++K
Sbjct: 1635 EEAERRAQQQAEAERAREEAERELERWQLKANEALR-LRLQAEEVAQQKSLAQAEAEKQK 1693

Query: 320  LEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLE 379
             E  R+ RR+ K  + Q   Q E+    L+ + +++   A      +   ++       E
Sbjct: 1694 EEAEREARRRGKAEE-QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ--ELIRLRAETE 1750

Query: 380  QAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILL----QKDYESASLT 435
            Q E+   + L  E+ RL+R    A + RQ+          + ++LL    + + ES S +
Sbjct: 1751 QGEQ-QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1809

Query: 436  EVRALLRKHEAFE-SDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKI-CDQWDRL 493
            E      + EA    +LA    R+  +A  A+   +L   DA       +++  ++   +
Sbjct: 1810 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1869

Query: 494  GTLTQKRREAL----------ERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMF 543
            G  T+ + EA           ER+ +L E          ++AA     +E  +  L+   
Sbjct: 1870 GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 1929

Query: 544  IVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVT 603
                +E  + L+      + TL +     + I+A++   EK                +  
Sbjct: 1930 D-SELERQKGLV------EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1982

Query: 604  MDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNK--MEEIA 661
             D LR+K     +    R  + +EE  R+ A ER+++  AA+  A     Q K  +EE+ 
Sbjct: 1983 EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR---QRKAALEEVE 2039

Query: 662  RSSIQITGA 670
            R   ++  A
Sbjct: 2040 RLKAKVEEA 2048



 Score = 37.0 bits (84), Expect = 0.082
 Identities = 79/379 (20%), Positives = 151/379 (39%), Gaps = 32/379 (8%)

Query: 265  AANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFR 324
            A NR   +   +     L EE E++     E  R ++   E     +  +    +     
Sbjct: 2276 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALA 2335

Query: 325  DYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKG 384
            +   K K   VQE  +L+     LQ +  ++   A    E K    +A   Q+L +  +G
Sbjct: 2336 EKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDK--EQMA---QQLAEETQG 2390

Query: 385  YEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYES--ASLTEVRALLR 442
            ++  L  E  R  +LE  AE  R K    E     + Q   ++D +       E+   L 
Sbjct: 2391 FQRTL--EAERQRQLEMSAEAERLKLRVAEM---SRAQARAEEDAQRFRKQAEEIGEKLH 2445

Query: 443  KHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRRE 502
            + E       A Q++V  +  +  +  + D HDA  + +   ++  + ++L    Q+  +
Sbjct: 2446 RTEL------ATQEKVTLVQTLEIQRQQSD-HDAERLREAIAELEREKEKL----QQEAK 2494

Query: 503  ALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFK 562
             L+   + ++T+ Q  L    +A   +   E      ++ FI     +++ L      F+
Sbjct: 2495 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL------FQ 2548

Query: 563  ATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRD 622
              + +A   R+     Q ++E+  Q     +  +        + +R K ++++QL   R 
Sbjct: 2549 DEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRR 2608

Query: 623  QSLQEELARQHANERLRRQ 641
            Q  QEEL  +  N+RLR Q
Sbjct: 2609 Q--QEELLAEE-NQRLREQ 2624



 Score = 34.3 bits (77), Expect = 0.53
 Identities = 56/264 (21%), Positives = 105/264 (39%), Gaps = 61/264 (23%)

Query: 434  LTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQ--WD 491
            L  +  ++R  +  E  L AH++++++  A+   L EL+   A     R Q    Q  +D
Sbjct: 1115 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1174

Query: 492  RLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEI 551
             L       R+ L   +++ E + Q H    +R      W E   + L            
Sbjct: 1175 AL-------RDELRGAQEVGERLQQRH---GERDVEVERWRERVAQLL------------ 1212

Query: 552  QSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKW 611
                   E+++A L + D         Q E+E++ +       S++P      D  R + 
Sbjct: 1213 -------ERWQAVLAQTD-------VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ- 1257

Query: 612  DKVKQLVPIRD-QSLQEELARQHA-NERLRRQFAAQANAIGPWIQNKMEEIARSSIQITG 669
             +  Q +P+ D Q+++E+L ++ A  E + R               K+EE  R + Q   
Sbjct: 1258 -EQIQAMPLADSQAVREQLRQEQALLEEIERH------------GEKVEECQRFAKQ--- 1301

Query: 670  ALEDQMNQLKQYEHNIINYKNNID 693
                 +N +K YE  ++ YK  ++
Sbjct: 1302 ----YINAIKDYELQLVTYKAQLE 1321



 Score = 32.7 bits (73), Expect = 1.5
 Identities = 78/425 (18%), Positives = 163/425 (38%), Gaps = 63/425 (14%)

Query: 281  RLMEEYERLASELLEWIR---------RTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHK 331
            R +  Y   A  L  W++         + +P  +++   + ++  Q  LE+   +  K  
Sbjct: 1234 RQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK-- 1291

Query: 332  PPKVQEKCQ------------LEINFNTLQTKLRISNRPAFMP-----SEGKMVS--DIA 372
                 E+CQ             E+   T + +L     PA  P     SE  +    D+ 
Sbjct: 1292 ----VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLR 1347

Query: 373  GAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESA 432
              +  L      Y +++   +RR+E  E LAE  +Q+A   E  A  +  +  Q+    A
Sbjct: 1348 THYSELTTLTSQYIKFISETLRRMEEEERLAE--QQRAEERERLAEVEAALEKQRQLAEA 1405

Query: 433  SLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDR 492
                     R+ +  +  +     R E+ A  AQ+          ++ +  Q++    + 
Sbjct: 1406 HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKR-------SIQEELQQLRQSSEA 1458

Query: 493  LGTLTQKRREALERMEKLLE---TIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIE 549
                  ++ EA ER    +E    + +L LE  +R        EG ++ L+        +
Sbjct: 1459 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ---RGGAEGELQALRARAEEAEAQ 1515

Query: 550  EIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRT 609
            + Q+   A    +    E+  +RQ+ + + + V+   ++     +     +   ++ELR 
Sbjct: 1516 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEA-----AREKQRALQALEELRL 1570

Query: 610  KWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITG 669
            + ++ ++    R +  + E ARQ        Q +A+A      +Q+K    A  + Q+  
Sbjct: 1571 QAEEAER----RLRQAEVERARQVQVALETAQRSAEAE-----LQSKRASFAEKTAQLER 1621

Query: 670  ALEDQ 674
            +L+++
Sbjct: 1622 SLQEE 1626


>gi|34577047 dystonin isoform 1 [Homo sapiens]
          Length = 5497

 Score =  237 bits (605), Expect = 3e-62
 Identities = 141/401 (35%), Positives = 222/401 (55%), Gaps = 19/401 (4%)

Query: 12  YVYDEDEYMIQEEEWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLK 71
           Y+Y E++  +Q  E   +   D   +K Q+KTFT W N HL K    + ++ ED R+G  
Sbjct: 10  YLYVEEQEYLQAYEDVLERYKDER-DKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHN 68

Query: 72  LMLLLEVISGERLPKPDRGKMRFHKIANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTL 131
           L+ LLEV+SG+ LP+ ++G+MRFH++ NV  ALDY+  + VKLV+I  ++I DGN K+TL
Sbjct: 69  LISLLEVLSGDTLPR-EKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTL 127

Query: 132 GMIWTIILRFAIQDISV----EETSAKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLC 187
           G+IWTIIL F I DI V    E+ SAKE LLLW Q+ T  Y  +  +NF T W+DG    
Sbjct: 128 GLIWTIILHFQISDIHVTGESEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFN 187

Query: 188 ALIHRHRPDLIDYSKLNKDDPIGNINLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMT 247
           A+IH++RPDLID + +     + N+  A  +AEK + + ++LD ED V+   PDE++++T
Sbjct: 188 AIIHKYRPDLIDMNTVAVQSNLANLEHAFYVAEK-IGVIRLLDPED-VDVSSPDEKSVIT 245

Query: 248 YVSCFYHAFAGAEQAETAANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENR 307
           YVS  Y AF    +           +  N    + + EY+ + + L++WIR  +  +  R
Sbjct: 246 YVSSLYDAFPKVPEGGEG-------IGANDVEVKWI-EYQNMVNYLIQWIRHHVTTMSER 297

Query: 308 TPEKTMQAMQKKLEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKM 367
           T       ++     +  ++    PPK  EK +++  +  L+  +           +G  
Sbjct: 298 TFPNNPVELKALYNQYLQFKETEIPPKETEKSKIKRLYKLLEIWIEFGRIKLL---QGYH 354

Query: 368 VSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQ 408
            +DI   W +L  A    E+ L  E+ RLE L+ +A + ++
Sbjct: 355 PNDIEKEWGKLIIAMLEREKALRPEVERLEMLQQIANRVQR 395



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 78/408 (19%), Positives = 156/408 (38%), Gaps = 29/408 (7%)

Query: 271  KVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLED---FRDYR 327
            KV+    E  R +++  + A +  E   + + WLE    EK++ +  +   D    +   
Sbjct: 4601 KVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEES--EKSLDSELEIANDPDKIKTQL 4658

Query: 328  RKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGK---MVSDIAGAWQRLEQAEKG 384
             +HK  +     +  +   T +T   +  + +      K   M+S++   W  +    K 
Sbjct: 4659 AQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTI--CGKS 4716

Query: 385  YEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKH 444
             E        +LE     + +F         W Y  E  L +       +  V  L+  H
Sbjct: 4717 VERQ-----NKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNH 4771

Query: 445  EAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREAL 504
            +AF+ +L      V+ +   A+EL E    D+  V  + Q++  +W+ +  L+  ++  L
Sbjct: 4772 KAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRL 4831

Query: 505  ERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEE-IQSLITAHEQFKA 563
            E   +  E       EF         W+  A + L+   ++   E+ +++LI  H++F  
Sbjct: 4832 EAALRQAE-------EFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMK 4884

Query: 564  TLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQ 623
             L E   E      + + V  +    +  I++   + T+    +R ++++V        Q
Sbjct: 4885 KLEEKRAELNKATTMGDTVLAICHPDS--ITTIKHWITI----IRARFEEVLAWAKQHQQ 4938

Query: 624  SLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITGAL 671
             L   LA   A + L     A        + +K +E+    I+   AL
Sbjct: 4939 RLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKAL 4986



 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 79/424 (18%), Positives = 167/424 (39%), Gaps = 55/424 (12%)

Query: 220  EKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQAETAANRICKVLAVNQEN 279
            ++ LDI   L +E I    +PD+  +   +     A+    +A    +RI K+    +E 
Sbjct: 4126 QEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWK--DRIDKL----EEA 4179

Query: 280  ERLMEEYERLASELLEWIRRTIPWLENRTPEKT-MQAMQKKLEDFRDYRRKHKPPKVQEK 338
             +   +Y+     + +W+      L + +P  T ++ +++++E+ + ++         E 
Sbjct: 4180 MQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFK--------SEA 4231

Query: 339  CQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLER 398
             Q +I    L  +  +  +     S+   V D       L+      EE ++N   +LE 
Sbjct: 4232 YQQQIEMERLNHQAELLLKKVTEESDKHTVQD---PLMELKLIWDSLEERIINRQHKLEG 4288

Query: 399  LEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRV 458
                  +F+        W    E +L ++         +   L KH   ++D+ AHQ  V
Sbjct: 4289 ALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTV 4348

Query: 459  EQIAAIAQELNELDY-HDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQL 517
            E +     +L E     +A N+ ++ + +  +W  +   T++R++ L+            
Sbjct: 4349 EAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGA---------- 4398

Query: 518  HLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSI-- 575
                 ++A  F+    G +EDLQ       + + +  + A +     LPE   E+ ++  
Sbjct: 4399 ----LRQAKGFH----GEIEDLQQW-----LTDTERHLLASKPL-GGLPETAKEQLNVHM 4444

Query: 576  -----MAIQNEVEKVIQSYNIRISSSNPYSTVT-----MDELRTKWDKVKQLVPIRDQSL 625
                    + E  K +     ++ +  P S  T     ++ L+ KW+ V+  +  R   L
Sbjct: 4445 EVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKL 4504

Query: 626  QEEL 629
            +E L
Sbjct: 4505 EEAL 4508



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 60/332 (18%), Positives = 136/332 (40%), Gaps = 42/332 (12%)

Query: 315  AMQKKLEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSE-GKMVSDIAG 373
            AM ++LE      +K K    QEK Q+++    L   L    +  ++ +E  + +  I  
Sbjct: 2685 AMNQQLET----AQKMKQEIQQEKKQIKVA-QALCEDLSALVKEEYLKAELSRQLEGILK 2739

Query: 374  AWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESAS 433
            +++ +EQ  +       N ++ L+     + +F+Q +   + W   K++   +    SA 
Sbjct: 2740 SFKDVEQKAE-------NHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAK 2792

Query: 434  LTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQE-LNELDYHDAVNVNDRCQKICDQWDR 492
            L  + +L++ H+ F   L A     E+  A  +  L +    +   +  +   I   WD 
Sbjct: 2793 LDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDT 2852

Query: 493  LGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQ 552
                    ++  ER  KL E++++  L++ ++      W++    +L             
Sbjct: 2853 F------NKQVKERENKLKESLEKA-LKYKEQVETLWPWIDKCQNNL------------- 2892

Query: 553  SLITAHEQFKATLPEADGERQ--SIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTK 610
                  E+ K  L  A+GE     + ++Q E+++      +  +++N   +V   +    
Sbjct: 2893 ------EEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVV 2946

Query: 611  WDKVKQLVPIRDQSLQEELARQHANERLRRQF 642
             D+ K L+   D   ++  +++   E + ++F
Sbjct: 2947 TDENKSLIQKVDMVTEQLHSKKFCLENMTQKF 2978



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 94/516 (18%), Positives = 203/516 (39%), Gaps = 74/516 (14%)

Query: 266  ANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDF-- 323
            AN+ CK++   +E    +   +R    L +   + +   + R  E+ ++   K+LE+F  
Sbjct: 3145 ANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAR--EEQVEGTIKRLEEFYS 3202

Query: 324  --RDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFM-----PSEGKMVSDIAGAWQ 376
              +++    +  +  E+ Q  +   T     +++    F      P +GK   D+    Q
Sbjct: 3203 KLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQ-QDVNWLGQ 3261

Query: 377  RLEQAE------KGYEE--------WLLNEIRRLERLEHLAE------KFRQKASTHETW 416
             L Q+       +G E         W     +  +R   L E      +F+    +  +W
Sbjct: 3262 GLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSW 3321

Query: 417  AYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQEL-NELDYHD 475
                E+++  +   SA    V+A +++ +  +  L   +  VE I    +++    +  D
Sbjct: 3322 MVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3381

Query: 476  AVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGA 535
             V +  +   +  +W+ L    + R   LE +  + +       +F +   P N W+   
Sbjct: 3382 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQ-------QFHETLEPLNEWLTTI 3434

Query: 536  MEDLQDMF-IVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIR-- 592
             + L +   I     +++  I  H+  +  +   +      ++I   + KV+ S   +  
Sbjct: 3435 EKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSL-KVLSSREDKDM 3493

Query: 593  ISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPW 652
            + S   +S V   E++ K          R + LQ+ L          + F      +  W
Sbjct: 3494 VQSKLDFSQVWYIEIQEKSHS-------RSELLQQALCN-------AKIFGEDEVELMNW 3539

Query: 653  IQNKMEEIARSSIQ--ITGALEDQMNQLKQYEHNIINYKNNIDK--LEGDHQLIQ----E 704
            +    +++++ S+Q   T  L  Q ++L+  + +I+  K N+D+  L G   L Q    E
Sbjct: 3540 LNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDE 3599

Query: 705  ALVFDNKHTNYTMEHIRVGWE---LLLTTIARTINE 737
             L+  +K     +E I+  ++    L T +A+T+ +
Sbjct: 3600 VLIIQDK-----LEAIKARYKDITKLSTDVAKTLEQ 3630



 Score = 37.7 bits (86), Expect = 0.048
 Identities = 54/275 (19%), Positives = 106/275 (38%), Gaps = 32/275 (11%)

Query: 283  MEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKH--KPPKVQEKCQ 340
            ++ ++ L   L  WI+ T   +    P    + + K LED +  + K   K P++Q+   
Sbjct: 2288 LDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNN 2347

Query: 341  LEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQ----------------AEKG 384
              I+   L + +    +       G  V +  G     E+                   G
Sbjct: 2348 SGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHG 2407

Query: 385  YEE---WLLNEIRRLERLEHLAEKFRQKASTHETW--AYGKEQILLQKDYESASLTEVRA 439
            YE+    L ++I  L       +K ++++S    W     K     Q+         V+ 
Sbjct: 2408 YEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKT 2467

Query: 440  LLRKHEAFESDLAAHQDRVEQIAAIAQELNE--LDYHDAVNVNDRCQKICDQWDRLGTLT 497
             + ++++FE++L  + ++V+++     EL E   D  +A        +I  +W  L  LT
Sbjct: 2468 QVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLT 2527

Query: 498  QKRREALERMEKLLETIDQLHLEFAKRAAPFNNWM 532
                  ++R +KL E+ + L  +F    A    W+
Sbjct: 2528 ------IDRQQKLEESSNNL-TQFQTVEAQLKQWL 2555



 Score = 37.7 bits (86), Expect = 0.048
 Identities = 57/281 (20%), Positives = 119/281 (42%), Gaps = 41/281 (14%)

Query: 387  EWLLNEI----RRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLR 442
            E LLN+     R+LE +  +A++F +       W    E+ L+  +      +++   + 
Sbjct: 3397 EALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIA 3456

Query: 443  KHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQW-----DRLGTLT 497
            +H+A E D+  H   + Q  +I Q L  L   +  ++          W     ++  + +
Sbjct: 3457 QHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRS 3516

Query: 498  QKRREAL-------ERMEKLLETIDQLHLEFAKRAAPFNN----W-MEGAMEDLQDMFIV 545
            +  ++AL       E   +L+  ++++H + +K +    +    W  +  +  LQ+  ++
Sbjct: 3517 ELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILL 3576

Query: 546  HSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSY-NIRISSSNPYSTV-- 602
                  Q+L+   E  K T  +       ++ IQ+++E +   Y +I   S++   T+  
Sbjct: 3577 RKQNVDQALLNGLELLKQTTGD------EVLIIQDKLEAIKARYKDITKLSTDVAKTLEQ 3630

Query: 603  ----------TMDELRTKWDKVK-QLVPIRDQSLQEELARQ 632
                      T +EL T  DKV+ +L+    Q L+ E A Q
Sbjct: 3631 ALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQ 3671



 Score = 34.3 bits (77), Expect = 0.53
 Identities = 54/258 (20%), Positives = 90/258 (34%), Gaps = 30/258 (11%)

Query: 354  ISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEE---WLLNEIRRLE-RLEHLAEKFRQK 409
            I N  AF    GK  S +    +   +  +G  +   W+  +++ L  R E +      K
Sbjct: 4768 IDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISK 4827

Query: 410  ASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELN 469
             +  E      E+           L E    LR H     D  A +  ++Q     ++L 
Sbjct: 4828 QTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLE 4887

Query: 470  E--LDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAKRAA- 526
            E   + + A  + D    IC   D + T+         R E++L    Q     A   A 
Sbjct: 4888 EKRAELNKATTMGDTVLAICHP-DSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAG 4946

Query: 527  ------------PFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQS 574
                         +  W E  + D     I   IEE+++LI  H+ F           + 
Sbjct: 4947 LIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTF----------MEE 4996

Query: 575  IMAIQNEVEKVIQSYNIR 592
            +   Q +V+KV ++Y  R
Sbjct: 4997 MTRKQPDVDKVTKTYKRR 5014



 Score = 33.5 bits (75), Expect = 0.91
 Identities = 50/220 (22%), Positives = 89/220 (40%), Gaps = 39/220 (17%)

Query: 502 EALERME----KLLET-------IDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEE 550
           E L R+E    KLL T       +D LH  F  RA     W+    E+     + +   E
Sbjct: 675 EKLHRLESQYAKLLNTSRNQERHLDTLH-NFVSRATNELIWLNEKEEEE----VAYDWSE 729

Query: 551 IQSLITAHEQFKATLP-EADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRT 609
             + I   + + A L  E D + ++I ++Q   E+++   +    +   Y       ++T
Sbjct: 730 RNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAA----MQT 785

Query: 610 KWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIAR------- 662
           +W  + QL    +Q ++E  A          +F   A     +++N  + I R       
Sbjct: 786 QWSWILQLCQCVEQHIKENTAYF--------EFFNDAKEATDYLRNLKDAIQRKYSCDRS 837

Query: 663 SSIQITGALEDQMNQLKQYEHNIINYKNNIDKLEGDHQLI 702
           SSI     LED + +  + +  ++ YK+ I  L G  + I
Sbjct: 838 SSIH---KLEDLVQESMEEKEELLQYKSTIANLMGKAKTI 874


>gi|169218211 PREDICTED: similar to plectin 1, partial [Homo
           sapiens]
          Length = 1369

 Score =  237 bits (604), Expect = 4e-62
 Identities = 185/630 (29%), Positives = 298/630 (47%), Gaps = 39/630 (6%)

Query: 37  EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPKPDRGKMRFHK 96
           ++ Q+KT T W N HL KA   I ++ ED R+G  L+ LLEV+SG+ LP+ ++G+MRFHK
Sbjct: 174 DRVQKKTSTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFHK 232

Query: 97  IANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISV----EETS 152
           + NV  ALDY+  + VKLV+I  ++I DGN K+TLG+IWTIIL F I DI V    E+ +
Sbjct: 233 LQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMT 292

Query: 153 AKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPDLIDYSKLNKDDPIGNI 212
           AKE LLLW QR    Y+ +   NF +SW+DG    A+IHRH+P LID +K+ +   + N+
Sbjct: 293 AKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENL 352

Query: 213 NLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQAETAANRICKV 272
           + A  +AE+ L + ++LD ED V+ P+PDE++I+TYVS  Y A       +         
Sbjct: 353 DQAFSVAERDLGVTRLLDPED-VDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRA---- 407

Query: 273 LAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHKP 332
                E +   +EY  L   LL+W+R      E R    + + ++     F  ++    P
Sbjct: 408 ----NELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELP 463

Query: 333 PKVQEKCQLEINFNTLQTKL---RISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWL 389
            K  +K + +  + +L+  +   ++   P + P       D+   W +L  A    E+ L
Sbjct: 464 AKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHP------LDVEKEWGKLHVAILEREKQL 517

Query: 390 LNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFES 449
            +E  RLE L+ +  K + +A   E   + +   LLQ D    +  +V    ++    E 
Sbjct: 518 RSEFERLECLQRIVTKLQMEAGLCEEQLH-QADALLQSDIRLLAAGKVP---QRAGEVER 573

Query: 450 DLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEK 509
           DL      +  +    Q L +  +     +  R  ++ ++   + T    R +A   +  
Sbjct: 574 DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKA--GVAA 631

Query: 510 LLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEAD 569
               + Q+ L+  +R        +  +  LQD  ++  +EE Q  +   E +   LP  +
Sbjct: 632 PATQVAQVTLQSVQRRPELE---DSTLRYLQD--LLAWVEENQHRVDGAE-WGVDLPSVE 685

Query: 570 GERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQEEL 629
            +  S   +   +E+         S     S  T    R   D + +L     + L    
Sbjct: 686 AQLGSHRGLHQSIEEFQAKIERARSDEGQLSPATRGAYR---DCLGRLDLQYAKLLNSSK 742

Query: 630 ARQHANERLRRQFAAQANAIGPWIQNKMEE 659
           AR  + E L   F A A     W+  K EE
Sbjct: 743 ARLRSLESL-HSFVAAATKELMWLNEKEEE 771


>gi|221316624 dystonin isoform 4 [Homo sapiens]
          Length = 5526

 Score =  234 bits (598), Expect = 2e-61
 Identities = 135/376 (35%), Positives = 211/376 (56%), Gaps = 18/376 (4%)

Query: 37  EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPKPDRGKMRFHK 96
           +K Q+KTFT W N HL K    + ++ ED R+G  L+ LLEV+SG+ LP+ ++G+MRFH+
Sbjct: 63  DKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPR-EKGRMRFHR 121

Query: 97  IANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISV----EETS 152
           + NV  ALDY+  + VKLV+I  ++I DGN K+TLG+IWTIIL F I DI V    E+ S
Sbjct: 122 LQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESEDMS 181

Query: 153 AKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPDLIDYSKLNKDDPIGNI 212
           AKE LLLW Q+ T  Y  +  +NF T W+DG    A+IH++RPDLID + +     + N+
Sbjct: 182 AKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANL 241

Query: 213 NLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQAETAANRICKV 272
             A  +AEK + + ++LD ED V+   PDE++++TYVS  Y AF    +           
Sbjct: 242 EHAFYVAEK-IGVIRLLDPED-VDVSSPDEKSVITYVSSLYDAFPKVPEGGEG------- 292

Query: 273 LAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHKP 332
           +  N    + + EY+ + + L++WIR  +  +  RT       ++     +  ++    P
Sbjct: 293 IGANDVEVKWI-EYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIP 351

Query: 333 PKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNE 392
           PK  EK +++  +  L+  +           +G   +DI   W +L  A    E+ L  E
Sbjct: 352 PKETEKSKIKRLYKLLEIWIEFGRIKLL---QGYHPNDIEKEWGKLIIAMLEREKALRPE 408

Query: 393 IRRLERLEHLAEKFRQ 408
           + RLE L+ +A + ++
Sbjct: 409 VERLEMLQQIANRVQR 424



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 78/408 (19%), Positives = 156/408 (38%), Gaps = 29/408 (7%)

Query: 271  KVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLED---FRDYR 327
            KV+    E  R +++  + A +  E   + + WLE    EK++ +  +   D    +   
Sbjct: 4630 KVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEES--EKSLDSELEIANDPDKIKTQL 4687

Query: 328  RKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGK---MVSDIAGAWQRLEQAEKG 384
             +HK  +     +  +   T +T   +  + +      K   M+S++   W  +    K 
Sbjct: 4688 AQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTI--CGKS 4745

Query: 385  YEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKH 444
             E        +LE     + +F         W Y  E  L +       +  V  L+  H
Sbjct: 4746 VERQ-----NKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNH 4800

Query: 445  EAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREAL 504
            +AF+ +L      V+ +   A+EL E    D+  V  + Q++  +W+ +  L+  ++  L
Sbjct: 4801 KAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRL 4860

Query: 505  ERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEE-IQSLITAHEQFKA 563
            E   +  E       EF         W+  A + L+   ++   E+ +++LI  H++F  
Sbjct: 4861 EAALRQAE-------EFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMK 4913

Query: 564  TLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQ 623
             L E   E      + + V  +    +  I++   + T+    +R ++++V        Q
Sbjct: 4914 KLEEKRAELNKATTMGDTVLAICHPDS--ITTIKHWITI----IRARFEEVLAWAKQHQQ 4967

Query: 624  SLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITGAL 671
             L   LA   A + L     A        + +K +E+    I+   AL
Sbjct: 4968 RLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKAL 5015



 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 79/424 (18%), Positives = 167/424 (39%), Gaps = 55/424 (12%)

Query: 220  EKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQAETAANRICKVLAVNQEN 279
            ++ LDI   L +E I    +PD+  +   +     A+    +A    +RI K+    +E 
Sbjct: 4155 QEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWK--DRIDKL----EEA 4208

Query: 280  ERLMEEYERLASELLEWIRRTIPWLENRTPEKT-MQAMQKKLEDFRDYRRKHKPPKVQEK 338
             +   +Y+     + +W+      L + +P  T ++ +++++E+ + ++         E 
Sbjct: 4209 MQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFK--------SEA 4260

Query: 339  CQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLER 398
             Q +I    L  +  +  +     S+   V D       L+      EE ++N   +LE 
Sbjct: 4261 YQQQIEMERLNHQAELLLKKVTEESDKHTVQD---PLMELKLIWDSLEERIINRQHKLEG 4317

Query: 399  LEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRV 458
                  +F+        W    E +L ++         +   L KH   ++D+ AHQ  V
Sbjct: 4318 ALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTV 4377

Query: 459  EQIAAIAQELNELDY-HDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQL 517
            E +     +L E     +A N+ ++ + +  +W  +   T++R++ L+            
Sbjct: 4378 EAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGA---------- 4427

Query: 518  HLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSI-- 575
                 ++A  F+    G +EDLQ       + + +  + A +     LPE   E+ ++  
Sbjct: 4428 ----LRQAKGFH----GEIEDLQQW-----LTDTERHLLASKPL-GGLPETAKEQLNVHM 4473

Query: 576  -----MAIQNEVEKVIQSYNIRISSSNPYSTVT-----MDELRTKWDKVKQLVPIRDQSL 625
                    + E  K +     ++ +  P S  T     ++ L+ KW+ V+  +  R   L
Sbjct: 4474 EVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKL 4533

Query: 626  QEEL 629
            +E L
Sbjct: 4534 EEAL 4537



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 60/332 (18%), Positives = 136/332 (40%), Gaps = 42/332 (12%)

Query: 315  AMQKKLEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSE-GKMVSDIAG 373
            AM ++LE      +K K    QEK Q+++    L   L    +  ++ +E  + +  I  
Sbjct: 2714 AMNQQLET----AQKMKQEIQQEKKQIKVA-QALCEDLSALVKEEYLKAELSRQLEGILK 2768

Query: 374  AWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESAS 433
            +++ +EQ  +       N ++ L+     + +F+Q +   + W   K++   +    SA 
Sbjct: 2769 SFKDVEQKAE-------NHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAK 2821

Query: 434  LTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQE-LNELDYHDAVNVNDRCQKICDQWDR 492
            L  + +L++ H+ F   L A     E+  A  +  L +    +   +  +   I   WD 
Sbjct: 2822 LDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDT 2881

Query: 493  LGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQ 552
                    ++  ER  KL E++++  L++ ++      W++    +L             
Sbjct: 2882 F------NKQVKERENKLKESLEKA-LKYKEQVETLWPWIDKCQNNL------------- 2921

Query: 553  SLITAHEQFKATLPEADGERQ--SIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTK 610
                  E+ K  L  A+GE     + ++Q E+++      +  +++N   +V   +    
Sbjct: 2922 ------EEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVV 2975

Query: 611  WDKVKQLVPIRDQSLQEELARQHANERLRRQF 642
             D+ K L+   D   ++  +++   E + ++F
Sbjct: 2976 TDENKSLIQKVDMVTEQLHSKKFCLENMTQKF 3007



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 94/516 (18%), Positives = 203/516 (39%), Gaps = 74/516 (14%)

Query: 266  ANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDF-- 323
            AN+ CK++   +E    +   +R    L +   + +   + R  E+ ++   K+LE+F  
Sbjct: 3174 ANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAR--EEQVEGTIKRLEEFYS 3231

Query: 324  --RDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFM-----PSEGKMVSDIAGAWQ 376
              +++    +  +  E+ Q  +   T     +++    F      P +GK   D+    Q
Sbjct: 3232 KLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQ-QDVNWLGQ 3290

Query: 377  RLEQAE------KGYEE--------WLLNEIRRLERLEHLAE------KFRQKASTHETW 416
             L Q+       +G E         W     +  +R   L E      +F+    +  +W
Sbjct: 3291 GLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSW 3350

Query: 417  AYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQEL-NELDYHD 475
                E+++  +   SA    V+A +++ +  +  L   +  VE I    +++    +  D
Sbjct: 3351 MVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3410

Query: 476  AVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGA 535
             V +  +   +  +W+ L    + R   LE +  + +       +F +   P N W+   
Sbjct: 3411 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQ-------QFHETLEPLNEWLTTI 3463

Query: 536  MEDLQDMF-IVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIR-- 592
             + L +   I     +++  I  H+  +  +   +      ++I   + KV+ S   +  
Sbjct: 3464 EKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSL-KVLSSREDKDM 3522

Query: 593  ISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPW 652
            + S   +S V   E++ K          R + LQ+ L          + F      +  W
Sbjct: 3523 VQSKLDFSQVWYIEIQEKSHS-------RSELLQQALCN-------AKIFGEDEVELMNW 3568

Query: 653  IQNKMEEIARSSIQ--ITGALEDQMNQLKQYEHNIINYKNNIDK--LEGDHQLIQ----E 704
            +    +++++ S+Q   T  L  Q ++L+  + +I+  K N+D+  L G   L Q    E
Sbjct: 3569 LNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDE 3628

Query: 705  ALVFDNKHTNYTMEHIRVGWE---LLLTTIARTINE 737
             L+  +K     +E I+  ++    L T +A+T+ +
Sbjct: 3629 VLIIQDK-----LEAIKARYKDITKLSTDVAKTLEQ 3659



 Score = 37.7 bits (86), Expect = 0.048
 Identities = 54/275 (19%), Positives = 106/275 (38%), Gaps = 32/275 (11%)

Query: 283  MEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKH--KPPKVQEKCQ 340
            ++ ++ L   L  WI+ T   +    P    + + K LED +  + K   K P++Q+   
Sbjct: 2317 LDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNN 2376

Query: 341  LEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQ----------------AEKG 384
              I+   L + +    +       G  V +  G     E+                   G
Sbjct: 2377 SGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHG 2436

Query: 385  YEE---WLLNEIRRLERLEHLAEKFRQKASTHETW--AYGKEQILLQKDYESASLTEVRA 439
            YE+    L ++I  L       +K ++++S    W     K     Q+         V+ 
Sbjct: 2437 YEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKT 2496

Query: 440  LLRKHEAFESDLAAHQDRVEQIAAIAQELNE--LDYHDAVNVNDRCQKICDQWDRLGTLT 497
             + ++++FE++L  + ++V+++     EL E   D  +A        +I  +W  L  LT
Sbjct: 2497 QVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLT 2556

Query: 498  QKRREALERMEKLLETIDQLHLEFAKRAAPFNNWM 532
                  ++R +KL E+ + L  +F    A    W+
Sbjct: 2557 ------IDRQQKLEESSNNL-TQFQTVEAQLKQWL 2584



 Score = 37.7 bits (86), Expect = 0.048
 Identities = 57/281 (20%), Positives = 119/281 (42%), Gaps = 41/281 (14%)

Query: 387  EWLLNEI----RRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLR 442
            E LLN+     R+LE +  +A++F +       W    E+ L+  +      +++   + 
Sbjct: 3426 EALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIA 3485

Query: 443  KHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQW-----DRLGTLT 497
            +H+A E D+  H   + Q  +I Q L  L   +  ++          W     ++  + +
Sbjct: 3486 QHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRS 3545

Query: 498  QKRREAL-------ERMEKLLETIDQLHLEFAKRAAPFNN----W-MEGAMEDLQDMFIV 545
            +  ++AL       E   +L+  ++++H + +K +    +    W  +  +  LQ+  ++
Sbjct: 3546 ELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILL 3605

Query: 546  HSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSY-NIRISSSNPYSTV-- 602
                  Q+L+   E  K T  +       ++ IQ+++E +   Y +I   S++   T+  
Sbjct: 3606 RKQNVDQALLNGLELLKQTTGD------EVLIIQDKLEAIKARYKDITKLSTDVAKTLEQ 3659

Query: 603  ----------TMDELRTKWDKVK-QLVPIRDQSLQEELARQ 632
                      T +EL T  DKV+ +L+    Q L+ E A Q
Sbjct: 3660 ALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQ 3700



 Score = 34.3 bits (77), Expect = 0.53
 Identities = 54/258 (20%), Positives = 90/258 (34%), Gaps = 30/258 (11%)

Query: 354  ISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEE---WLLNEIRRLE-RLEHLAEKFRQK 409
            I N  AF    GK  S +    +   +  +G  +   W+  +++ L  R E +      K
Sbjct: 4797 IDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISK 4856

Query: 410  ASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELN 469
             +  E      E+           L E    LR H     D  A +  ++Q     ++L 
Sbjct: 4857 QTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLE 4916

Query: 470  E--LDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAKRAA- 526
            E   + + A  + D    IC   D + T+         R E++L    Q     A   A 
Sbjct: 4917 EKRAELNKATTMGDTVLAICHP-DSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAG 4975

Query: 527  ------------PFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQS 574
                         +  W E  + D     I   IEE+++LI  H+ F           + 
Sbjct: 4976 LIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTF----------MEE 5025

Query: 575  IMAIQNEVEKVIQSYNIR 592
            +   Q +V+KV ++Y  R
Sbjct: 5026 MTRKQPDVDKVTKTYKRR 5043



 Score = 33.5 bits (75), Expect = 0.91
 Identities = 50/220 (22%), Positives = 89/220 (40%), Gaps = 39/220 (17%)

Query: 502 EALERME----KLLET-------IDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEE 550
           E L R+E    KLL T       +D LH  F  RA     W+    E+     + +   E
Sbjct: 704 EKLHRLESQYAKLLNTSRNQERHLDTLH-NFVSRATNELIWLNEKEEEE----VAYDWSE 758

Query: 551 IQSLITAHEQFKATLP-EADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRT 609
             + I   + + A L  E D + ++I ++Q   E+++   +    +   Y       ++T
Sbjct: 759 RNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAA----MQT 814

Query: 610 KWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIAR------- 662
           +W  + QL    +Q ++E  A          +F   A     +++N  + I R       
Sbjct: 815 QWSWILQLCQCVEQHIKENTAYF--------EFFNDAKEATDYLRNLKDAIQRKYSCDRS 866

Query: 663 SSIQITGALEDQMNQLKQYEHNIINYKNNIDKLEGDHQLI 702
           SSI     LED + +  + +  ++ YK+ I  L G  + I
Sbjct: 867 SSIH---KLEDLVQESMEEKEELLQYKSTIANLMGKAKTI 903


>gi|221316622 dystonin isoform 3 [Homo sapiens]
          Length = 5537

 Score =  234 bits (598), Expect = 2e-61
 Identities = 135/376 (35%), Positives = 211/376 (56%), Gaps = 18/376 (4%)

Query: 37  EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPKPDRGKMRFHK 96
           +K Q+KTFT W N HL K    + ++ ED R+G  L+ LLEV+SG+ LP+ ++G+MRFH+
Sbjct: 74  DKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPR-EKGRMRFHR 132

Query: 97  IANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISV----EETS 152
           + NV  ALDY+  + VKLV+I  ++I DGN K+TLG+IWTIIL F I DI V    E+ S
Sbjct: 133 LQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESEDMS 192

Query: 153 AKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPDLIDYSKLNKDDPIGNI 212
           AKE LLLW Q+ T  Y  +  +NF T W+DG    A+IH++RPDLID + +     + N+
Sbjct: 193 AKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANL 252

Query: 213 NLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQAETAANRICKV 272
             A  +AEK + + ++LD ED V+   PDE++++TYVS  Y AF    +           
Sbjct: 253 EHAFYVAEK-IGVIRLLDPED-VDVSSPDEKSVITYVSSLYDAFPKVPEGGEG------- 303

Query: 273 LAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHKP 332
           +  N    + + EY+ + + L++WIR  +  +  RT       ++     +  ++    P
Sbjct: 304 IGANDVEVKWI-EYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIP 362

Query: 333 PKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNE 392
           PK  EK +++  +  L+  +           +G   +DI   W +L  A    E+ L  E
Sbjct: 363 PKETEKSKIKRLYKLLEIWIEFGRIKLL---QGYHPNDIEKEWGKLIIAMLEREKALRPE 419

Query: 393 IRRLERLEHLAEKFRQ 408
           + RLE L+ +A + ++
Sbjct: 420 VERLEMLQQIANRVQR 435



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 78/408 (19%), Positives = 156/408 (38%), Gaps = 29/408 (7%)

Query: 271  KVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLED---FRDYR 327
            KV+    E  R +++  + A +  E   + + WLE    EK++ +  +   D    +   
Sbjct: 4641 KVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEES--EKSLDSELEIANDPDKIKTQL 4698

Query: 328  RKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGK---MVSDIAGAWQRLEQAEKG 384
             +HK  +     +  +   T +T   +  + +      K   M+S++   W  +    K 
Sbjct: 4699 AQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTI--CGKS 4756

Query: 385  YEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKH 444
             E        +LE     + +F         W Y  E  L +       +  V  L+  H
Sbjct: 4757 VERQ-----NKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNH 4811

Query: 445  EAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREAL 504
            +AF+ +L      V+ +   A+EL E    D+  V  + Q++  +W+ +  L+  ++  L
Sbjct: 4812 KAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRL 4871

Query: 505  ERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEE-IQSLITAHEQFKA 563
            E   +  E       EF         W+  A + L+   ++   E+ +++LI  H++F  
Sbjct: 4872 EAALRQAE-------EFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMK 4924

Query: 564  TLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQ 623
             L E   E      + + V  +    +  I++   + T+    +R ++++V        Q
Sbjct: 4925 KLEEKRAELNKATTMGDTVLAICHPDS--ITTIKHWITI----IRARFEEVLAWAKQHQQ 4978

Query: 624  SLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITGAL 671
             L   LA   A + L     A        + +K +E+    I+   AL
Sbjct: 4979 RLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKAL 5026



 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 79/424 (18%), Positives = 167/424 (39%), Gaps = 55/424 (12%)

Query: 220  EKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQAETAANRICKVLAVNQEN 279
            ++ LDI   L +E I    +PD+  +   +     A+    +A    +RI K+    +E 
Sbjct: 4166 QEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWK--DRIDKL----EEA 4219

Query: 280  ERLMEEYERLASELLEWIRRTIPWLENRTPEKT-MQAMQKKLEDFRDYRRKHKPPKVQEK 338
             +   +Y+     + +W+      L + +P  T ++ +++++E+ + ++         E 
Sbjct: 4220 MQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFK--------SEA 4271

Query: 339  CQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLER 398
             Q +I    L  +  +  +     S+   V D       L+      EE ++N   +LE 
Sbjct: 4272 YQQQIEMERLNHQAELLLKKVTEESDKHTVQD---PLMELKLIWDSLEERIINRQHKLEG 4328

Query: 399  LEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRV 458
                  +F+        W    E +L ++         +   L KH   ++D+ AHQ  V
Sbjct: 4329 ALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTV 4388

Query: 459  EQIAAIAQELNELDY-HDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQL 517
            E +     +L E     +A N+ ++ + +  +W  +   T++R++ L+            
Sbjct: 4389 EAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGA---------- 4438

Query: 518  HLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSI-- 575
                 ++A  F+    G +EDLQ       + + +  + A +     LPE   E+ ++  
Sbjct: 4439 ----LRQAKGFH----GEIEDLQQW-----LTDTERHLLASKPL-GGLPETAKEQLNVHM 4484

Query: 576  -----MAIQNEVEKVIQSYNIRISSSNPYSTVT-----MDELRTKWDKVKQLVPIRDQSL 625
                    + E  K +     ++ +  P S  T     ++ L+ KW+ V+  +  R   L
Sbjct: 4485 EVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKL 4544

Query: 626  QEEL 629
            +E L
Sbjct: 4545 EEAL 4548



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 60/332 (18%), Positives = 136/332 (40%), Gaps = 42/332 (12%)

Query: 315  AMQKKLEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSE-GKMVSDIAG 373
            AM ++LE      +K K    QEK Q+++    L   L    +  ++ +E  + +  I  
Sbjct: 2725 AMNQQLET----AQKMKQEIQQEKKQIKVA-QALCEDLSALVKEEYLKAELSRQLEGILK 2779

Query: 374  AWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESAS 433
            +++ +EQ  +       N ++ L+     + +F+Q +   + W   K++   +    SA 
Sbjct: 2780 SFKDVEQKAE-------NHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAK 2832

Query: 434  LTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQE-LNELDYHDAVNVNDRCQKICDQWDR 492
            L  + +L++ H+ F   L A     E+  A  +  L +    +   +  +   I   WD 
Sbjct: 2833 LDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDT 2892

Query: 493  LGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQ 552
                    ++  ER  KL E++++  L++ ++      W++    +L             
Sbjct: 2893 F------NKQVKERENKLKESLEKA-LKYKEQVETLWPWIDKCQNNL------------- 2932

Query: 553  SLITAHEQFKATLPEADGERQ--SIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTK 610
                  E+ K  L  A+GE     + ++Q E+++      +  +++N   +V   +    
Sbjct: 2933 ------EEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVV 2986

Query: 611  WDKVKQLVPIRDQSLQEELARQHANERLRRQF 642
             D+ K L+   D   ++  +++   E + ++F
Sbjct: 2987 TDENKSLIQKVDMVTEQLHSKKFCLENMTQKF 3018



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 94/516 (18%), Positives = 203/516 (39%), Gaps = 74/516 (14%)

Query: 266  ANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDF-- 323
            AN+ CK++   +E    +   +R    L +   + +   + R  E+ ++   K+LE+F  
Sbjct: 3185 ANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAR--EEQVEGTIKRLEEFYS 3242

Query: 324  --RDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFM-----PSEGKMVSDIAGAWQ 376
              +++    +  +  E+ Q  +   T     +++    F      P +GK   D+    Q
Sbjct: 3243 KLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQ-QDVNWLGQ 3301

Query: 377  RLEQAE------KGYEE--------WLLNEIRRLERLEHLAE------KFRQKASTHETW 416
             L Q+       +G E         W     +  +R   L E      +F+    +  +W
Sbjct: 3302 GLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSW 3361

Query: 417  AYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQEL-NELDYHD 475
                E+++  +   SA    V+A +++ +  +  L   +  VE I    +++    +  D
Sbjct: 3362 MVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3421

Query: 476  AVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGA 535
             V +  +   +  +W+ L    + R   LE +  + +       +F +   P N W+   
Sbjct: 3422 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQ-------QFHETLEPLNEWLTTI 3474

Query: 536  MEDLQDMF-IVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIR-- 592
             + L +   I     +++  I  H+  +  +   +      ++I   + KV+ S   +  
Sbjct: 3475 EKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSL-KVLSSREDKDM 3533

Query: 593  ISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPW 652
            + S   +S V   E++ K          R + LQ+ L          + F      +  W
Sbjct: 3534 VQSKLDFSQVWYIEIQEKSHS-------RSELLQQALCN-------AKIFGEDEVELMNW 3579

Query: 653  IQNKMEEIARSSIQ--ITGALEDQMNQLKQYEHNIINYKNNIDK--LEGDHQLIQ----E 704
            +    +++++ S+Q   T  L  Q ++L+  + +I+  K N+D+  L G   L Q    E
Sbjct: 3580 LNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDE 3639

Query: 705  ALVFDNKHTNYTMEHIRVGWE---LLLTTIARTINE 737
             L+  +K     +E I+  ++    L T +A+T+ +
Sbjct: 3640 VLIIQDK-----LEAIKARYKDITKLSTDVAKTLEQ 3670



 Score = 37.7 bits (86), Expect = 0.048
 Identities = 54/275 (19%), Positives = 106/275 (38%), Gaps = 32/275 (11%)

Query: 283  MEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKH--KPPKVQEKCQ 340
            ++ ++ L   L  WI+ T   +    P    + + K LED +  + K   K P++Q+   
Sbjct: 2328 LDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNN 2387

Query: 341  LEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQ----------------AEKG 384
              I+   L + +    +       G  V +  G     E+                   G
Sbjct: 2388 SGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHG 2447

Query: 385  YEE---WLLNEIRRLERLEHLAEKFRQKASTHETW--AYGKEQILLQKDYESASLTEVRA 439
            YE+    L ++I  L       +K ++++S    W     K     Q+         V+ 
Sbjct: 2448 YEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKT 2507

Query: 440  LLRKHEAFESDLAAHQDRVEQIAAIAQELNE--LDYHDAVNVNDRCQKICDQWDRLGTLT 497
             + ++++FE++L  + ++V+++     EL E   D  +A        +I  +W  L  LT
Sbjct: 2508 QVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLT 2567

Query: 498  QKRREALERMEKLLETIDQLHLEFAKRAAPFNNWM 532
                  ++R +KL E+ + L  +F    A    W+
Sbjct: 2568 ------IDRQQKLEESSNNL-TQFQTVEAQLKQWL 2595



 Score = 37.7 bits (86), Expect = 0.048
 Identities = 57/281 (20%), Positives = 119/281 (42%), Gaps = 41/281 (14%)

Query: 387  EWLLNEI----RRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLR 442
            E LLN+     R+LE +  +A++F +       W    E+ L+  +      +++   + 
Sbjct: 3437 EALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIA 3496

Query: 443  KHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQW-----DRLGTLT 497
            +H+A E D+  H   + Q  +I Q L  L   +  ++          W     ++  + +
Sbjct: 3497 QHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRS 3556

Query: 498  QKRREAL-------ERMEKLLETIDQLHLEFAKRAAPFNN----W-MEGAMEDLQDMFIV 545
            +  ++AL       E   +L+  ++++H + +K +    +    W  +  +  LQ+  ++
Sbjct: 3557 ELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILL 3616

Query: 546  HSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSY-NIRISSSNPYSTV-- 602
                  Q+L+   E  K T  +       ++ IQ+++E +   Y +I   S++   T+  
Sbjct: 3617 RKQNVDQALLNGLELLKQTTGD------EVLIIQDKLEAIKARYKDITKLSTDVAKTLEQ 3670

Query: 603  ----------TMDELRTKWDKVK-QLVPIRDQSLQEELARQ 632
                      T +EL T  DKV+ +L+    Q L+ E A Q
Sbjct: 3671 ALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQ 3711



 Score = 34.3 bits (77), Expect = 0.53
 Identities = 54/258 (20%), Positives = 90/258 (34%), Gaps = 30/258 (11%)

Query: 354  ISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEE---WLLNEIRRLE-RLEHLAEKFRQK 409
            I N  AF    GK  S +    +   +  +G  +   W+  +++ L  R E +      K
Sbjct: 4808 IDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISK 4867

Query: 410  ASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELN 469
             +  E      E+           L E    LR H     D  A +  ++Q     ++L 
Sbjct: 4868 QTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLE 4927

Query: 470  E--LDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAKRAA- 526
            E   + + A  + D    IC   D + T+         R E++L    Q     A   A 
Sbjct: 4928 EKRAELNKATTMGDTVLAICHP-DSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAG 4986

Query: 527  ------------PFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQS 574
                         +  W E  + D     I   IEE+++LI  H+ F           + 
Sbjct: 4987 LIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTF----------MEE 5036

Query: 575  IMAIQNEVEKVIQSYNIR 592
            +   Q +V+KV ++Y  R
Sbjct: 5037 MTRKQPDVDKVTKTYKRR 5054



 Score = 33.5 bits (75), Expect = 0.91
 Identities = 50/220 (22%), Positives = 89/220 (40%), Gaps = 39/220 (17%)

Query: 502 EALERME----KLLET-------IDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEE 550
           E L R+E    KLL T       +D LH  F  RA     W+    E+     + +   E
Sbjct: 715 EKLHRLESQYAKLLNTSRNQERHLDTLH-NFVSRATNELIWLNEKEEEE----VAYDWSE 769

Query: 551 IQSLITAHEQFKATLP-EADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRT 609
             + I   + + A L  E D + ++I ++Q   E+++   +    +   Y       ++T
Sbjct: 770 RNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAA----MQT 825

Query: 610 KWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIAR------- 662
           +W  + QL    +Q ++E  A          +F   A     +++N  + I R       
Sbjct: 826 QWSWILQLCQCVEQHIKENTAYF--------EFFNDAKEATDYLRNLKDAIQRKYSCDRS 877

Query: 663 SSIQITGALEDQMNQLKQYEHNIINYKNNIDKLEGDHQLI 702
           SSI     LED + +  + +  ++ YK+ I  L G  + I
Sbjct: 878 SSIH---KLEDLVQESMEEKEELLQYKSTIANLMGKAKTI 914


>gi|221316618 dystonin isoform 2 [Homo sapiens]
          Length = 5675

 Score =  234 bits (598), Expect = 2e-61
 Identities = 135/376 (35%), Positives = 211/376 (56%), Gaps = 18/376 (4%)

Query: 37  EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPKPDRGKMRFHK 96
           +K Q+KTFT W N HL K    + ++ ED R+G  L+ LLEV+SG+ LP+ ++G+MRFH+
Sbjct: 212 DKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPR-EKGRMRFHR 270

Query: 97  IANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISV----EETS 152
           + NV  ALDY+  + VKLV+I  ++I DGN K+TLG+IWTIIL F I DI V    E+ S
Sbjct: 271 LQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESEDMS 330

Query: 153 AKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPDLIDYSKLNKDDPIGNI 212
           AKE LLLW Q+ T  Y  +  +NF T W+DG    A+IH++RPDLID + +     + N+
Sbjct: 331 AKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANL 390

Query: 213 NLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQAETAANRICKV 272
             A  +AEK + + ++LD ED V+   PDE++++TYVS  Y AF    +           
Sbjct: 391 EHAFYVAEK-IGVIRLLDPED-VDVSSPDEKSVITYVSSLYDAFPKVPEGGEG------- 441

Query: 273 LAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHKP 332
           +  N    + + EY+ + + L++WIR  +  +  RT       ++     +  ++    P
Sbjct: 442 IGANDVEVKWI-EYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIP 500

Query: 333 PKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNE 392
           PK  EK +++  +  L+  +           +G   +DI   W +L  A    E+ L  E
Sbjct: 501 PKETEKSKIKRLYKLLEIWIEFGRIKLL---QGYHPNDIEKEWGKLIIAMLEREKALRPE 557

Query: 393 IRRLERLEHLAEKFRQ 408
           + RLE L+ +A + ++
Sbjct: 558 VERLEMLQQIANRVQR 573



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 78/408 (19%), Positives = 156/408 (38%), Gaps = 29/408 (7%)

Query: 271  KVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLED---FRDYR 327
            KV+    E  R +++  + A +  E   + + WLE    EK++ +  +   D    +   
Sbjct: 4779 KVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEES--EKSLDSELEIANDPDKIKTQL 4836

Query: 328  RKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGK---MVSDIAGAWQRLEQAEKG 384
             +HK  +     +  +   T +T   +  + +      K   M+S++   W  +    K 
Sbjct: 4837 AQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTI--CGKS 4894

Query: 385  YEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKH 444
             E        +LE     + +F         W Y  E  L +       +  V  L+  H
Sbjct: 4895 VERQ-----NKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNH 4949

Query: 445  EAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREAL 504
            +AF+ +L      V+ +   A+EL E    D+  V  + Q++  +W+ +  L+  ++  L
Sbjct: 4950 KAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRL 5009

Query: 505  ERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEE-IQSLITAHEQFKA 563
            E   +  E       EF         W+  A + L+   ++   E+ +++LI  H++F  
Sbjct: 5010 EAALRQAE-------EFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMK 5062

Query: 564  TLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQ 623
             L E   E      + + V  +    +  I++   + T+    +R ++++V        Q
Sbjct: 5063 KLEEKRAELNKATTMGDTVLAICHPDS--ITTIKHWITI----IRARFEEVLAWAKQHQQ 5116

Query: 624  SLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITGAL 671
             L   LA   A + L     A        + +K +E+    I+   AL
Sbjct: 5117 RLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKAL 5164



 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 79/424 (18%), Positives = 167/424 (39%), Gaps = 55/424 (12%)

Query: 220  EKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQAETAANRICKVLAVNQEN 279
            ++ LDI   L +E I    +PD+  +   +     A+    +A    +RI K+    +E 
Sbjct: 4304 QEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWK--DRIDKL----EEA 4357

Query: 280  ERLMEEYERLASELLEWIRRTIPWLENRTPEKT-MQAMQKKLEDFRDYRRKHKPPKVQEK 338
             +   +Y+     + +W+      L + +P  T ++ +++++E+ + ++         E 
Sbjct: 4358 MQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFK--------SEA 4409

Query: 339  CQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLER 398
             Q +I    L  +  +  +     S+   V D       L+      EE ++N   +LE 
Sbjct: 4410 YQQQIEMERLNHQAELLLKKVTEESDKHTVQD---PLMELKLIWDSLEERIINRQHKLEG 4466

Query: 399  LEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRV 458
                  +F+        W    E +L ++         +   L KH   ++D+ AHQ  V
Sbjct: 4467 ALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTV 4526

Query: 459  EQIAAIAQELNELDY-HDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQL 517
            E +     +L E     +A N+ ++ + +  +W  +   T++R++ L+            
Sbjct: 4527 EAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGA---------- 4576

Query: 518  HLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSI-- 575
                 ++A  F+    G +EDLQ       + + +  + A +     LPE   E+ ++  
Sbjct: 4577 ----LRQAKGFH----GEIEDLQQW-----LTDTERHLLASKPL-GGLPETAKEQLNVHM 4622

Query: 576  -----MAIQNEVEKVIQSYNIRISSSNPYSTVT-----MDELRTKWDKVKQLVPIRDQSL 625
                    + E  K +     ++ +  P S  T     ++ L+ KW+ V+  +  R   L
Sbjct: 4623 EVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKL 4682

Query: 626  QEEL 629
            +E L
Sbjct: 4683 EEAL 4686



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 60/332 (18%), Positives = 136/332 (40%), Gaps = 42/332 (12%)

Query: 315  AMQKKLEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSE-GKMVSDIAG 373
            AM ++LE      +K K    QEK Q+++    L   L    +  ++ +E  + +  I  
Sbjct: 2863 AMNQQLET----AQKMKQEIQQEKKQIKVA-QALCEDLSALVKEEYLKAELSRQLEGILK 2917

Query: 374  AWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESAS 433
            +++ +EQ  +       N ++ L+     + +F+Q +   + W   K++   +    SA 
Sbjct: 2918 SFKDVEQKAE-------NHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAK 2970

Query: 434  LTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQE-LNELDYHDAVNVNDRCQKICDQWDR 492
            L  + +L++ H+ F   L A     E+  A  +  L +    +   +  +   I   WD 
Sbjct: 2971 LDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDT 3030

Query: 493  LGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQ 552
                    ++  ER  KL E++++  L++ ++      W++    +L             
Sbjct: 3031 F------NKQVKERENKLKESLEKA-LKYKEQVETLWPWIDKCQNNL------------- 3070

Query: 553  SLITAHEQFKATLPEADGERQ--SIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTK 610
                  E+ K  L  A+GE     + ++Q E+++      +  +++N   +V   +    
Sbjct: 3071 ------EEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVV 3124

Query: 611  WDKVKQLVPIRDQSLQEELARQHANERLRRQF 642
             D+ K L+   D   ++  +++   E + ++F
Sbjct: 3125 TDENKSLIQKVDMVTEQLHSKKFCLENMTQKF 3156



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 94/516 (18%), Positives = 203/516 (39%), Gaps = 74/516 (14%)

Query: 266  ANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDF-- 323
            AN+ CK++   +E    +   +R    L +   + +   + R  E+ ++   K+LE+F  
Sbjct: 3323 ANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAR--EEQVEGTIKRLEEFYS 3380

Query: 324  --RDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFM-----PSEGKMVSDIAGAWQ 376
              +++    +  +  E+ Q  +   T     +++    F      P +GK   D+    Q
Sbjct: 3381 KLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQ-QDVNWLGQ 3439

Query: 377  RLEQAE------KGYEE--------WLLNEIRRLERLEHLAE------KFRQKASTHETW 416
             L Q+       +G E         W     +  +R   L E      +F+    +  +W
Sbjct: 3440 GLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSW 3499

Query: 417  AYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQEL-NELDYHD 475
                E+++  +   SA    V+A +++ +  +  L   +  VE I    +++    +  D
Sbjct: 3500 MVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3559

Query: 476  AVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGA 535
             V +  +   +  +W+ L    + R   LE +  + +       +F +   P N W+   
Sbjct: 3560 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQ-------QFHETLEPLNEWLTTI 3612

Query: 536  MEDLQDMF-IVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIR-- 592
             + L +   I     +++  I  H+  +  +   +      ++I   + KV+ S   +  
Sbjct: 3613 EKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSL-KVLSSREDKDM 3671

Query: 593  ISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPW 652
            + S   +S V   E++ K          R + LQ+ L          + F      +  W
Sbjct: 3672 VQSKLDFSQVWYIEIQEKSHS-------RSELLQQALCN-------AKIFGEDEVELMNW 3717

Query: 653  IQNKMEEIARSSIQ--ITGALEDQMNQLKQYEHNIINYKNNIDK--LEGDHQLIQ----E 704
            +    +++++ S+Q   T  L  Q ++L+  + +I+  K N+D+  L G   L Q    E
Sbjct: 3718 LNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDE 3777

Query: 705  ALVFDNKHTNYTMEHIRVGWE---LLLTTIARTINE 737
             L+  +K     +E I+  ++    L T +A+T+ +
Sbjct: 3778 VLIIQDK-----LEAIKARYKDITKLSTDVAKTLEQ 3808



 Score = 37.7 bits (86), Expect = 0.048
 Identities = 54/275 (19%), Positives = 106/275 (38%), Gaps = 32/275 (11%)

Query: 283  MEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKH--KPPKVQEKCQ 340
            ++ ++ L   L  WI+ T   +    P    + + K LED +  + K   K P++Q+   
Sbjct: 2466 LDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNN 2525

Query: 341  LEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQ----------------AEKG 384
              I+   L + +    +       G  V +  G     E+                   G
Sbjct: 2526 SGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHG 2585

Query: 385  YEE---WLLNEIRRLERLEHLAEKFRQKASTHETW--AYGKEQILLQKDYESASLTEVRA 439
            YE+    L ++I  L       +K ++++S    W     K     Q+         V+ 
Sbjct: 2586 YEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKT 2645

Query: 440  LLRKHEAFESDLAAHQDRVEQIAAIAQELNE--LDYHDAVNVNDRCQKICDQWDRLGTLT 497
             + ++++FE++L  + ++V+++     EL E   D  +A        +I  +W  L  LT
Sbjct: 2646 QVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLT 2705

Query: 498  QKRREALERMEKLLETIDQLHLEFAKRAAPFNNWM 532
                  ++R +KL E+ + L  +F    A    W+
Sbjct: 2706 ------IDRQQKLEESSNNL-TQFQTVEAQLKQWL 2733



 Score = 37.7 bits (86), Expect = 0.048
 Identities = 57/281 (20%), Positives = 119/281 (42%), Gaps = 41/281 (14%)

Query: 387  EWLLNEI----RRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLR 442
            E LLN+     R+LE +  +A++F +       W    E+ L+  +      +++   + 
Sbjct: 3575 EALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIA 3634

Query: 443  KHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQW-----DRLGTLT 497
            +H+A E D+  H   + Q  +I Q L  L   +  ++          W     ++  + +
Sbjct: 3635 QHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRS 3694

Query: 498  QKRREAL-------ERMEKLLETIDQLHLEFAKRAAPFNN----W-MEGAMEDLQDMFIV 545
            +  ++AL       E   +L+  ++++H + +K +    +    W  +  +  LQ+  ++
Sbjct: 3695 ELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILL 3754

Query: 546  HSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSY-NIRISSSNPYSTV-- 602
                  Q+L+   E  K T  +       ++ IQ+++E +   Y +I   S++   T+  
Sbjct: 3755 RKQNVDQALLNGLELLKQTTGD------EVLIIQDKLEAIKARYKDITKLSTDVAKTLEQ 3808

Query: 603  ----------TMDELRTKWDKVK-QLVPIRDQSLQEELARQ 632
                      T +EL T  DKV+ +L+    Q L+ E A Q
Sbjct: 3809 ALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQ 3849



 Score = 34.3 bits (77), Expect = 0.53
 Identities = 54/258 (20%), Positives = 90/258 (34%), Gaps = 30/258 (11%)

Query: 354  ISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEE---WLLNEIRRLE-RLEHLAEKFRQK 409
            I N  AF    GK  S +    +   +  +G  +   W+  +++ L  R E +      K
Sbjct: 4946 IDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISK 5005

Query: 410  ASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELN 469
             +  E      E+           L E    LR H     D  A +  ++Q     ++L 
Sbjct: 5006 QTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLE 5065

Query: 470  E--LDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAKRAA- 526
            E   + + A  + D    IC   D + T+         R E++L    Q     A   A 
Sbjct: 5066 EKRAELNKATTMGDTVLAICHP-DSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAG 5124

Query: 527  ------------PFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQS 574
                         +  W E  + D     I   IEE+++LI  H+ F           + 
Sbjct: 5125 LIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTF----------MEE 5174

Query: 575  IMAIQNEVEKVIQSYNIR 592
            +   Q +V+KV ++Y  R
Sbjct: 5175 MTRKQPDVDKVTKTYKRR 5192



 Score = 33.5 bits (75), Expect = 0.91
 Identities = 50/220 (22%), Positives = 89/220 (40%), Gaps = 39/220 (17%)

Query: 502  EALERME----KLLET-------IDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEE 550
            E L R+E    KLL T       +D LH  F  RA     W+    E+     + +   E
Sbjct: 853  EKLHRLESQYAKLLNTSRNQERHLDTLH-NFVSRATNELIWLNEKEEEE----VAYDWSE 907

Query: 551  IQSLITAHEQFKATLP-EADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRT 609
              + I   + + A L  E D + ++I ++Q   E+++   +    +   Y       ++T
Sbjct: 908  RNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAA----MQT 963

Query: 610  KWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIAR------- 662
            +W  + QL    +Q ++E  A          +F   A     +++N  + I R       
Sbjct: 964  QWSWILQLCQCVEQHIKENTAYF--------EFFNDAKEATDYLRNLKDAIQRKYSCDRS 1015

Query: 663  SSIQITGALEDQMNQLKQYEHNIINYKNNIDKLEGDHQLI 702
            SSI     LED + +  + +  ++ YK+ I  L G  + I
Sbjct: 1016 SSIH---KLEDLVQESMEEKEELLQYKSTIANLMGKAKTI 1052


>gi|33188445 microfilament and actin filament cross-linker protein
           isoform a [Homo sapiens]
          Length = 5430

 Score =  229 bits (584), Expect = 9e-60
 Identities = 194/685 (28%), Positives = 323/685 (47%), Gaps = 81/685 (11%)

Query: 22  QEEEWDRDLLLDPAW----------EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLK 71
           Q++   +D +LDPA           ++ Q+KTFT W N HL K    I ++ ED R+G  
Sbjct: 52  QKKRKSQDSVLDPAERAVVRVADERDRVQKKTFTKWVNKHLMKVRKHINDLYEDLRDGHN 111

Query: 72  LMLLLEVISGERLPKPDRGKMRFHKIANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTL 131
           L+ LLEV+SG +LP+ ++G+MRFH++ NV  ALD++  + VKLV+I  ++I DGN K+TL
Sbjct: 112 LISLLEVLSGIKLPR-EKGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTL 170

Query: 132 GMIWTIILRFAIQDISVE----ETSAKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLC 187
           G+IWTIIL F I DI +     + SAKE LLLW Q+ TA Y  +   NF + W DG    
Sbjct: 171 GLIWTIILHFQISDIYISGESGDMSAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFN 230

Query: 188 ALIHRHRPDLIDYSKLNKDDPIGNINLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMT 247
           ALIHR+RPDL+D  ++       N+  A E+AE+ L + ++LDAED V+ P PDE++++T
Sbjct: 231 ALIHRYRPDLVDMERVQIQSNRENLEQAFEVAER-LGVTRLLDAED-VDVPSPDEKSVIT 288

Query: 248 YVSCFYHAFAGAEQAETAANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENR 307
           YVS  Y AF    +     +          E +   +EY+     L+ WI++    + ++
Sbjct: 289 YVSSIYDAFPKVPEGGEGISA--------TEVDSRWQEYQSRVDSLIPWIKQHTILMSDK 340

Query: 308 TPEKTMQAMQKKLEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKM 367
           T  +    ++     +  ++      K +EK ++E  +  L+  +           +G  
Sbjct: 341 TFPQNPVELKALYNQYIHFKETEILAKEREKGRIEELYKLLEVWIEFGR---IKLPQGYH 397

Query: 368 VSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQK 427
            +D+   W +L       E+ L   + RLE L  +A K +  A   E      E++ L K
Sbjct: 398 PNDVEEEWGKLIIEMLEREKSLRPAVERLELLLQIANKIQNGALNCE------EKLTLAK 451

Query: 428 DYESASLTEVRALLRKHEAFESDLAAH----QDRVEQIAAIAQELNELDYHDAVNVNDRC 483
           +   A    + +   +    ESD+  +    +  + Q+    Q L + +Y+    +  R 
Sbjct: 452 NTLQADAAHLES--GQPVQCESDVIMYIQECEGLIRQLQVDLQILRDENYYQLEELAFRV 509

Query: 484 QKICDQWD--RLGTLTQKRR---EALERMEKLLETIDQLHLEFAKRA--APFNNWMEGAM 536
            ++ D+    RL      R+    +LE +     T   L  E   +A  +   +W    M
Sbjct: 510 MRLQDELVTLRLECTNLYRKGHFTSLELVPPSTLTTTHLKAEPLTKATHSSSTSWFRKPM 569

Query: 537 -----------EDLQDMFIVHS----IEEIQSLITAHEQFKATLPEADGERQSIMAIQNE 581
                      ED  ++  V+     +EE+Q  +   E +   LP  + + ++   I   
Sbjct: 570 TRAELVAISSSEDEGNLRFVYELLSWVEEMQMKLERAE-WGNDLPSVELQLETQQHIHTS 628

Query: 582 VEKVIQS------YNIRISSSNPYS-TVTMDELRTKWDKVKQLVPIRDQSLQEELARQHA 634
           VE++  S      Y  ++S +   S   T+ +L T++ K+K+    R + LQ        
Sbjct: 629 VEELGSSVKEARLYEGKMSQNFHTSYAETLGKLETQYCKLKETSSFRMRHLQS------- 681

Query: 635 NERLRRQFAAQANAIGPWIQNKMEE 659
                 +F ++A A   W+  K EE
Sbjct: 682 ----LHKFVSRATAELIWLNEKEEE 702



 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 75/390 (19%), Positives = 152/390 (38%), Gaps = 34/390 (8%)

Query: 271  KVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQA-MQKKLEDFRDYRRK 329
            KV+  + E  R +++  + A +  E  ++ I WLE+       +  +    +  +    K
Sbjct: 4576 KVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSK 4635

Query: 330  HKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWL 389
            HK  +     +  +   T++T   +  +   +P + + + +  G      +    ++   
Sbjct: 4636 HKEFQKTLGGKQPVYDTTIRTGRALKEK-TLLPEDSQKLDNFLG------EVRDKWDTVC 4688

Query: 390  LNEIRRLERLEH---LAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEA 446
               + R  +LE     + +F         W Y  E  L +       L  V  L+  H+ 
Sbjct: 4689 GKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKV 4748

Query: 447  FESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALER 506
            F+ +L      V+ +    +EL E    D   V  + Q++  +WD +  L+  ++  LE+
Sbjct: 4749 FQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQ 4808

Query: 507  MEKLLETI-DQLHLEFAKRAAPFNNWMEGAMEDLQDM-FIVHSIEEIQSLITAHEQFKAT 564
              K  E   D +H+           W+  A + L+    +    E +QSLI  H++F   
Sbjct: 4809 ALKQAEVFRDTVHM--------LLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKK 4860

Query: 565  LPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQS 624
            + E   +  S +A+   +  V   +   I++   + T+    +R ++++V        Q 
Sbjct: 4861 VEEKRVDVNSAVAMGEVILAV--CHPDCITTIKHWITI----IRARFEEVLTWAKQHQQR 4914

Query: 625  LQEELARQHANERLRRQFAAQANAIGPWIQ 654
            L+  L+   AN  L  +  A       WIQ
Sbjct: 4915 LETALSELVANAELLEELLA-------WIQ 4937



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 82/420 (19%), Positives = 176/420 (41%), Gaps = 47/420 (11%)

Query: 285  EYERLASELLEWIRRTIPWLENRTPEKTM-QAMQKKLEDFRDYRRKHKPPKVQEKCQLEI 343
            +Y+ L  +L E +R     L  ++   T  +A++++LE+  + R   +        QL+ 
Sbjct: 2625 QYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLE--------QLDH 2676

Query: 344  NFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLA 403
                 QT   + +  + +  E  +  ++    + +    +G E+   + I RL+      
Sbjct: 2677 EVKEAQT---LCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALAST 2733

Query: 404  EKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAA 463
            ++F+Q      TW   K+    +    SA L  +++ L+++E F+  L  H    E I A
Sbjct: 2734 QQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVA 2793

Query: 464  IAQE--LNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREAL-ERMEKLLETIDQLHLE 520
              +   L+     +   + ++  ++ + W+ L   T  R+  L + M+K  +   Q H+E
Sbjct: 2794 EGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKY--QWHVE 2851

Query: 521  FAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQN 580
                      W+E     + ++ +     +++S +    + KA L E + +R+S++ I N
Sbjct: 2852 ------DLVPWIEDCKAKMSELRVTLDPVQLESSLL---RSKAMLNEVE-KRRSLLEILN 2901

Query: 581  EVEKVIQSYNIRISSSNPYSTVTMDE---LRTKWDKVKQLVPIRDQSLQEELAR----QH 633
                ++      I+SS        DE   +    D V + +  +  SL+E   R    Q 
Sbjct: 2902 SAADIL------INSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQE 2955

Query: 634  ANERLRRQFAAQA------NAIGPW-IQNKMEEIARSSIQITGALEDQMNQLKQYEHNII 686
            + + + ++           +A+G     NK  E  R+  ++  ALE Q++ L+ +   ++
Sbjct: 2956 SFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLV 3015



 Score = 47.8 bits (112), Expect = 5e-05
 Identities = 97/486 (19%), Positives = 195/486 (40%), Gaps = 78/486 (16%)

Query: 214  LAMEIAEKHLDIPKML----DAEDIVNTPKPDERAIM-TYVSCFYHAFAGAEQAETAANR 268
            L  E+AE  + + K+     D  +I   P PD R +  T  S   H  + +      ++ 
Sbjct: 1980 LQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSL 2039

Query: 269  ICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKK-LEDFRDYR 327
            + K +A +Q              E LE + ++I  +E     K + ++    +++     
Sbjct: 2040 LQKAIAQSQS-----------VQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATN 2088

Query: 328  RKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEE 387
             K K    ++K  LE     +   +  ++       +GK+ ++++  +++L   ++  E 
Sbjct: 2089 MKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKL-AEVSQRFEQLCLQQQEKES 2147

Query: 388  WLLNEIRRLERLEHLAEKFRQ-KASTHETWAYGKE-------------QILLQKDYESAS 433
             L   + + E  EHL+ K +Q   +     A G +             ++ L+ + +  +
Sbjct: 2148 SLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQEN 2207

Query: 434  LTEVRALLRKHEA--FESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWD 491
            L  +  L+ +  +  F  DL  HQDRV+ +     EL +       + +  CQ+  D++ 
Sbjct: 2208 LDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASS-CQEQLDEFR 2266

Query: 492  RLGTLTQKRREALERMEKLLET---IDQLHLEFAKRAAPFNNW-MEGAMEDLQDMFIVHS 547
            +L    QK  +  E      ET     +L  +     +  ++W  +G +           
Sbjct: 2267 KLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTL----------- 2315

Query: 548  IEEIQSLITAHEQ--FKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYST---- 601
            +EEI    T+ E    + T P++ G+  SI          + S    + S N Y T    
Sbjct: 2316 VEEINCKGTSLENLIMEITAPDSQGKTGSI----------LPSVGSSVGSVNGYHTCKDL 2365

Query: 602  ----VTMDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKM 657
                  M ++  K++K+  ++  R +SLQ  L R         +   +AN++  W+++K 
Sbjct: 2366 TEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRM-------EEVHKEANSVLQWLESK- 2417

Query: 658  EEIARS 663
            EE+ +S
Sbjct: 2418 EEVLKS 2423



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 41/217 (18%), Positives = 90/217 (41%), Gaps = 21/217 (9%)

Query: 489  QWDRLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSI 548
            ++++LG +  +R+E+L+    +L  ++++H    K A     W+E   E L+ M  + S 
Sbjct: 2378 KYEKLGGVLHERQESLQA---ILNRMEEVH----KEANSVLQWLESKEEVLKSMDAMSSP 2430

Query: 549  EEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELR 608
             + +++    E  KA L E +     I  ++  +  ++ +Y     + N       +EL 
Sbjct: 2431 TKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKI--QEELN 2488

Query: 609  TKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQIT 668
            ++W++  ++   R + L+E  +           F A  + + PW+  K        + + 
Sbjct: 2489 SRWERATEVTVARQRQLEESASHLAC-------FQAAESQLRPWLMEK-----ELMMGVL 2536

Query: 669  GALEDQMNQLKQYEHNIINYKNNIDKLEGDHQLIQEA 705
            G L    N L   +  +       +     H+ + EA
Sbjct: 2537 GPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEA 2573



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 88/471 (18%), Positives = 184/471 (39%), Gaps = 55/471 (11%)

Query: 265  AANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTP-EKTMQAMQKKLEDF 323
            +A + C V  +  + E +   +  L  ++ + I +    L +    +  ++ +   L D 
Sbjct: 3237 SAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADT 3296

Query: 324  RDYRRKHKPPKVQEKC-QLEINFNTLQTKLRISNRPA---FMPSEGKMVSDIAGAWQR-- 377
             +     KPP  + K  + +I    L  +L + +R A    + +EG  ++  A    R  
Sbjct: 3297 EELIANQKPPSAEYKVVKAQIQEQKLLQRL-LDDRKATVDMLQAEGGRIAQSAELADREK 3355

Query: 378  ----LEQAEKGYEEWLLNEIRRLERLEH---LAEKFRQKASTHETWAYGKEQILLQKDYE 430
                LE  E  + E L     R ++LE    LA++F + A     +    E+ L   +  
Sbjct: 3356 ITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPV 3415

Query: 431  SASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQW 490
                 +++  + +H+A E D+  H   V Q   I Q L+ L       V      + ++ 
Sbjct: 3416 GTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGV------LSEKI 3469

Query: 491  DRLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEE 550
            D L     + ++   R   LL+        F +      NW+    + L  +F+    ++
Sbjct: 3470 DSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQD 3529

Query: 551  I-------------------QSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSY-N 590
            +                   +++  A +  +A L +  GE   ++ IQ +++ +   Y +
Sbjct: 3530 VLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGE--EVLLIQEKLDGIKTRYAD 3587

Query: 591  IRISSSNPYSTVTM-DELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAI 649
            I ++SS    T+    +L TK+    + +    + ++EELA          Q        
Sbjct: 3588 ITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQI------- 3640

Query: 650  GPWIQNKMEEIARSSIQITGALEDQMNQLKQYEHNIINY--KNNIDKLEGD 698
             P  Q + +E+ +  ++    L D +N++ +    ++ +  +  +DKL  D
Sbjct: 3641 -PQFQQRQKELKKEVMEHRLVL-DTVNEVSRALLELVPWRAREGLDKLVSD 3689



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 46/243 (18%), Positives = 100/243 (41%), Gaps = 26/243 (10%)

Query: 285  EYERLASELLEWIRRTIPWLENRTPEKT-MQAMQKKLEDFRD-----YRRKHKPPKVQEK 338
            +Y+     + +W+  T+  L    P  T +  ++ +L + ++     Y+++ +  K+  +
Sbjct: 4159 QYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQ 4218

Query: 339  CQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLER 398
             +L +   T +T   I   P         ++++   W+ L +     +  L   +  L +
Sbjct: 4219 GELMLKKATDETDRDIIREP---------LTELKHLWENLGEKIAHRQHKLEGALLALGQ 4269

Query: 399  LEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRV 458
             +H  E+         +W    E++L  +   S     +   L KH   ++D+ AHQ  V
Sbjct: 4270 FQHALEELM-------SWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATV 4322

Query: 459  EQIAAIAQELNELDY-HDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQL 517
            E +     EL E     DA ++  R + +   W+   ++ QK  E  ++++  L+     
Sbjct: 4323 ETVNKAGNELLESSAGDDASSLRSRLEAMNQCWE---SVLQKTEEREQQLQSTLQQAQGF 4379

Query: 518  HLE 520
            H E
Sbjct: 4380 HSE 4382



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 101/539 (18%), Positives = 214/539 (39%), Gaps = 83/539 (15%)

Query: 260  EQAETAANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTP---------- 309
            E+ E+   +   +  +N E    +E  + L ++  E      PW+E              
Sbjct: 3794 EKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAI 3853

Query: 310  -EKTMQAMQKKLEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMV 368
              + ++  Q+++   R+   +HKP  + +  ++      L             P EG+MV
Sbjct: 3854 DHEQLRQQQEEMRQLRESIAEHKP-HIDKLLKIGPQLKELN------------PEEGEMV 3900

Query: 369  SDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQ-- 426
             +      + ++AE  Y + +  E+R  +R   L E   Q  ST  T  + K + +L+  
Sbjct: 3901 EE------KYQKAENMYAQ-IKEEVR--QRALALDEAVSQ--STQITEFHDKIEPMLETL 3949

Query: 427  KDYES---------ASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAV 477
            ++  S         A + ++R  +  +++   +L   Q   E +    +EL  +      
Sbjct: 3950 ENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEEL--IGRSQGA 4007

Query: 478  NVNDRCQKICDQWDRLGTLTQK-RREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAM 536
            + +   ++I D+ D++    +  +  A ER  K L+ ++     +   AA         +
Sbjct: 4008 DKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTT-----I 4062

Query: 537  EDLQDMFIVHSIEE-------IQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSY 589
            +D QD  IVH +E        I+  + A E  K    E DG  + +  I+     +I + 
Sbjct: 4063 KDTQD--IVHDLESPGIDPSIIKQQVEAAETIKE---ETDGLHEELEFIRILGADLIFAC 4117

Query: 590  NIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAI 649
                 +  P    ++DE+   W+ + +    R + L++ +       +   Q+     A+
Sbjct: 4118 G---ETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAM-------QAAVQYQDTLQAM 4167

Query: 650  GPWIQNKMEEIARSSIQIT--GALEDQMNQLKQYEHNIINYKNNIDKL--EGDHQLIQEA 705
              W+ N + ++       T    ++DQ+N++K+++  +   +  ++KL  +G+  L +  
Sbjct: 4168 FDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKAT 4227

Query: 706  LVFDNKHTNYTMEHIRVGWELLLTTIARTINEVETQILTRDAKGITQEQMNEFRASFNH 764
               D       +  ++  WE L   IA   +++E  +L   A G  Q  + E  +   H
Sbjct: 4228 DETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALL---ALGQFQHALEELMSWLTH 4283



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 85/509 (16%), Positives = 196/509 (38%), Gaps = 71/509 (13%)

Query: 232  EDIVNTPKPDERAIMTYVSCFYHAFAGA-----EQAETAANRICKVLAVNQENERLMEEY 286
            E+IVN  K  ++AI    +              E+ +    R   +   + +  R +E+ 
Sbjct: 3543 EEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQA 3602

Query: 287  ERLASELLEWIRRTIPWLENRTPEKTMQAMQ----KKLEDFRDYRRKHKPPKVQEKCQLE 342
             +LA++          WL     E      Q    +++  F+  +++ K   ++ +  L+
Sbjct: 3603 RQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLD 3662

Query: 343  INFNTLQTKLRISNRPAFMPSEG--KMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLE 400
                  +  L +     +   EG  K+VSD         +  K   + +   +  ++   
Sbjct: 3663 TVNEVSRALLELV---PWRAREGLDKLVSDA-------NEQYKLVSDTIGQRVDEIDAAI 3712

Query: 401  HLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQ 460
              ++++ Q A     W    ++ L+          +  A L+  +AF  D+  H+D +++
Sbjct: 3713 QRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDE 3772

Query: 461  IAAIAQEL-NELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHL 519
            + +   E+           + ++ + +  Q++ +  L  +R   LER + L+        
Sbjct: 3773 LFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVN------- 3825

Query: 520  EFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQ 579
            +F +     + W                IEE ++LI       A LP    + + +   Q
Sbjct: 3826 QFWETYEELSPW----------------IEETRALI-------AQLPSPAIDHEQLRQQQ 3862

Query: 580  NEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQEELAR-QHANERL 638
             E+ ++ +S    I+   P+    +D+L     ++K+L P   + ++E+  + ++   ++
Sbjct: 3863 EEMRQLRES----IAEHKPH----IDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQI 3914

Query: 639  RRQFAAQANAIGPWIQNKMEEIARSSIQITGALEDQMNQLKQYEHNIINYKNNIDKLEGD 698
            + +   +A A        ++E    S QIT    D++  + +   N+ +       +  +
Sbjct: 3915 KEEVRQRALA--------LDEAVSQSTQIT-EFHDKIEPMLETLENLSSRLRMPPLIPAE 3965

Query: 699  HQLIQEALVFDNKHTNYTMEHIRVGWELL 727
               I+E  + DNK     +E ++  +E L
Sbjct: 3966 VDKIREC-ISDNKSATVELEKLQPSFEAL 3993



 Score = 39.3 bits (90), Expect = 0.017
 Identities = 72/457 (15%), Positives = 183/457 (40%), Gaps = 31/457 (6%)

Query: 255  AFAGAEQAETAANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQ 314
            A   A Q ET  ++  K LA N++    + ++          +   +P +E  +     +
Sbjct: 1660 AVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEK 1719

Query: 315  AMQKKLEDFRDYRRKHKPPKVQEKCQL------EINFNTLQTKLRISNRPAFMPSEGKMV 368
                  + +    +   P K+ ++C++      E+        L   +  AF+   G  +
Sbjct: 1720 GALDTTDGYMGVNQA--PEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNL 1777

Query: 369  S--DIAGAWQRLEQAEKGYEEWLLN---EIRRLERLEHLAEKFRQKASTHETWAYGKEQI 423
            +  +     Q+L + ++ Y   L     E+++++ L+   +KF Q     E+W    E+ 
Sbjct: 1778 TPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKE 1837

Query: 424  LLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRC 483
            L       +S   + +LL++  +F  D+ +H+  +  +    Q++  LD  ++       
Sbjct: 1838 LENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKV--LDMENSFKEGKEP 1895

Query: 484  QKICD-QWDRLGTLTQKRREALERMEKLLETIDQL---HLEFAKRAAPFNNWM---EGAM 536
             +I +   D+L   T++      +  +L   ++ L   + +F   A     WM   E  +
Sbjct: 1896 SEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANV 1955

Query: 537  EDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSS 596
            E L    +      +Q  +   +Q +  L E     + +  +  ++ ++        +  
Sbjct: 1956 EKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEI----EGEPAPD 2011

Query: 597  NPYSTVTMDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNK 656
            + +   T D + + +  +   +  R   LQ+ +A+   ++ ++    +   +IG  ++  
Sbjct: 2012 HRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQ---SQSVQESLESLLQSIGE-VEQN 2067

Query: 657  MEEIARSSIQITGALEDQMNQLKQYEHNIINYKNNID 693
            +E    SS+  +G +++ +    + + +I   K++++
Sbjct: 2068 LEGKQVSSLS-SGVIQEALATNMKLKQDIARQKSSLE 2103


>gi|115298659 spectrin, alpha, erythrocytic 1 [Homo sapiens]
          Length = 2419

 Score =  206 bits (525), Expect = 6e-53
 Identities = 132/503 (26%), Positives = 252/503 (50%), Gaps = 23/503 (4%)

Query: 400  EHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAA-HQDRV 458
            ++  ++F  KA   E W   KE  L + +   A L +   LL K +  ++ L +  Q+R+
Sbjct: 1927 DYAFQEFNWKADVVEAWIADKETSL-KTNGNGADLGDFLTLLAKQDTLDASLQSFQQERL 1985

Query: 459  EQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLH 518
             +I  +  +L    ++ +  + +R   +  +W++L   +   R+ L   +  L+  + L 
Sbjct: 1986 PEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLF 2045

Query: 519  LEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIMAI 578
            +EFA +A+  NNW E   E+L +     S+ EI+ L   HE F A+L  A  + + ++  
Sbjct: 2046 VEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLL-- 2103

Query: 579  QNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQEELARQHANERL 638
              E+++ I++  +    S+PY+ +T++ L   W  +  ++  R+Q LQ+E ARQ  N  +
Sbjct: 2104 --ELDQQIKALGV---PSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEM 2158

Query: 639  RRQFAAQANAIGPWI-QNKMEEIARSSIQITGALEDQMNQLKQYEHNIINYKNNIDKLEG 697
             ++F   A+    WI + +   +  S ++ TG LE Q+   K+ +  I   K  + K+  
Sbjct: 2159 CQEFEQNASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVD 2218

Query: 698  DHQLIQEALVFDNKHTNYTMEHIRVGWELLLTTIARTINEVETQILTRDAKGITQEQMNE 757
                +++AL+ D K   Y+   +   W+ L     R  + +E QI  +D KG+++E + E
Sbjct: 2219 LGDNLEDALILDIK---YSTIGLAQQWDQLYQLGLRMQHNLEQQIQAKDIKGVSEETLKE 2275

Query: 758  FRASFNHFDRRKNGLMDHEDFRACLISMGY-------DLGEAEFARIMTLVDPNGQGTVT 810
            F   + HFD    G + H++FR+CL  + Y       D  E +F + +  VDP  +G V+
Sbjct: 2276 FSTIYKHFDENLTGRLTHKEFRSCLRGLNYYLPMVEEDEHEPKFEKFLDAVDPGRKGYVS 2335

Query: 811  FQSFIDFM-TRETADTDTAEQVIASFRILASDKPYILAEELRRELPPDQAQYCIKRMPAY 869
             + +  F+  +E+ +  +++++  +F+ LA  K YI  E++++ L P+Q  +C   M  Y
Sbjct: 2336 LEDYTAFLIDKESENIKSSDEIENAFQALAEGKSYITKEDMKQALTPEQVSFCATHMQQY 2395

Query: 870  SGP--GSVPGALDYAAFSSALYG 890
              P   S     DY  F+++ +G
Sbjct: 2396 MDPRGRSHLSGYDYVGFTNSYFG 2418



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 94/446 (21%), Positives = 183/446 (41%), Gaps = 63/446 (14%)

Query: 277  QENERLMEEYERL-----ASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHK 331
            +   RL++ Y        A ++LEWI+           EK  +    +L+D  + ++K  
Sbjct: 1073 ERRRRLLQRYNEFLLAYEAGDMLEWIQ-----------EKKAENTGVELDDVWELQKKFD 1121

Query: 332  PPKVQEKCQLEINFNTLQTKLRISNRPAF-MPSEGKMVSDIAGAWQRLEQAEKGYEEWLL 390
                    + + + NT + +LR  N+ A  +  EG +  + A   Q L  +  G  + L 
Sbjct: 1122 --------EFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQELN-SRWGSLQRLA 1172

Query: 391  NEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESD 450
            +E R+L    H  E F ++A   +     K Q L   D   + L  V+AL R+HE FE D
Sbjct: 1173 DEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAAD-PGSDLFSVQALQRRHEGFERD 1231

Query: 451  LAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKL 510
            L    D+V  +   A+ L+E       ++  +  ++ + W+ L   T+ R+E+L   +K 
Sbjct: 1232 LVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKF 1291

Query: 511  LETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADG 570
                      F  +A    NW+      +    +   +  I+ L+  H++ +A   + + 
Sbjct: 1292 --------YLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRA---DMEA 1340

Query: 571  ERQSIMAIQNEVEKVIQS---YNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQE 627
            E  +  A+++   ++I S    +  I        +  D+L   W+K K+++   DQ L+ 
Sbjct: 1341 EAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKIL---DQCLEL 1397

Query: 628  ELARQHANERLRRQFAAQANAIGPWI---QNKMEEIARSSIQITGAL----EDQMNQLKQ 680
            ++            F    + +  W+   +N +    +SS+    AL    +D    +  
Sbjct: 1398 QM------------FQGNCDQVESWMVARENSLRSDDKSSLDSLEALMKKRDDLDKAITA 1445

Query: 681  YEHNIINYKNNIDKLEGDHQLIQEAL 706
             E  I + ++  + L  D    +E +
Sbjct: 1446 QEGKITDLEHFAESLIADEHYAKEEI 1471



 Score = 60.1 bits (144), Expect = 9e-09
 Identities = 53/258 (20%), Positives = 114/258 (44%), Gaps = 17/258 (6%)

Query: 375  WQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASL 434
            W++L +A   + + LL +   L++ E L  +F  KAS    W    E+  L +     SL
Sbjct: 2017 WEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEE-NLSEPVHCVSL 2075

Query: 435  TEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLG 494
             E+R L + HE F + LA  Q   + +  + Q++  L    +       + +   W  L 
Sbjct: 2076 NEIRQLQKDHEDFLASLARAQADFKCLLELDQQIKALGVPSSPYTWLTVEVLERTWKHLS 2135

Query: 495  TLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSL 554
             + ++R + L++ E       ++  EF + A+ F  W+        D  ++     ++S 
Sbjct: 2136 DIIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQWILETRAYFLDGSLLKETGTLESQ 2195

Query: 555  ITAHEQFKATLPEADGERQSIMAIQNEVEKVI---QSYNIRISSSNPYSTVTMDELRTKW 611
            + A+++          +++ I A++ ++ K++    +    +     YST+    L  +W
Sbjct: 2196 LEANKR----------KQKEIQAMKRQLTKIVDLGDNLEDALILDIKYSTI---GLAQQW 2242

Query: 612  DKVKQLVPIRDQSLQEEL 629
            D++ QL      +L++++
Sbjct: 2243 DQLYQLGLRMQHNLEQQI 2260



 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 60/294 (20%), Positives = 113/294 (38%), Gaps = 29/294 (9%)

Query: 284 EEYERLASELLEWI---RRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHKPPKVQEKCQ 340
           ++Y +  +++LEWI         +E     +  + + KK EDF+         ++  K  
Sbjct: 161 QQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKKFEDFQ--------VELVAKEG 212

Query: 341 LEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLE 400
             +  N    +    N P     + K  +++  AW+RL       ++ L N         
Sbjct: 213 RVVEVNQYANECAEENHPDLPLIQSKQ-NEVNAAWERLRGLALQRQKALSNAAN------ 265

Query: 401 HLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQ 460
              ++F++  +    W   KE +L  +DY    L     L   H+  E +LA   D+V++
Sbjct: 266 --LQRFKRDVTEAIQWIKEKEPVLTSEDY-GKDLVASEGLFHSHKGLERNLAVMSDKVKE 322

Query: 461 IAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHLE 520
           + A A++L      DA  + +  + +   W+ +  L      A  R EKL  T    +  
Sbjct: 323 LCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRAL------ATSRYEKLQAT--YWYHR 374

Query: 521 FAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQS 574
           F+      + WM      +    +   +   + L+  H+Q K  +   D   QS
Sbjct: 375 FSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQS 428



 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 81/458 (17%), Positives = 176/458 (38%), Gaps = 54/458 (11%)

Query: 279 NERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHK--PPKVQ 336
           N   ++ ++R  +E ++WI+   P L +    K + A +      +   R       KV+
Sbjct: 262 NAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVK 321

Query: 337 EKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRL 396
           E C           KL +S+ P+  P   +M  D+  +W+ +                R 
Sbjct: 322 ELC-------AKAEKLTLSH-PSDAPQIQEMKEDLVSSWEHIRALATS----------RY 363

Query: 397 ERLEHLAEKFRQKASTHETWAYGKEQIL-LQKDYESASLTEVRALLRKHEAFESDLAAHQ 455
           E+L+      R  +   E   +  E+   +  D     +     LL +H+  + ++ ++ 
Sbjct: 364 EKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYD 423

Query: 456 DRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETID 515
           DR +      Q+L   ++  +  V ++ + + + W  L  L  +R    E      + +D
Sbjct: 424 DRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYE------QCLD 477

Query: 516 QLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSI 575
             HL F + +   ++WM      L++  + +S+   ++L+  HE F+        + + I
Sbjct: 478 -FHL-FYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAF---TAQEEKI 532

Query: 576 MAIQNEVEKVI-----QSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQEELA 630
           + +     K+I      S NI+            D L  + D +++    R + L+E L 
Sbjct: 533 ITVDKTATKLIGDDHYDSENIK---------AIRDGLLARRDALREKAATRRRLLKESLL 583

Query: 631 RQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITGALEDQMNQLKQYEHNIINYKN 690
            Q   E         ++ +  WI  K +       +    L+ ++ + + +E  +   K 
Sbjct: 584 LQKLYE--------DSDDLKNWINKKKKLADDEDYKDIQNLKSRVQKQQVFEKELAVNKT 635

Query: 691 NIDKLEGDHQLIQEALVFDNKHTNYTMEHIRVGWELLL 728
            ++ ++   Q + E   + + +    +  +   WE LL
Sbjct: 636 QLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELL 673



 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 34/165 (20%), Positives = 74/165 (44%), Gaps = 10/165 (6%)

Query: 394 RRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAA 453
           RRL +   L +K  + +   + W   K+++   +DY+   +  +++ ++K + FE +LA 
Sbjct: 575 RRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDYKD--IQNLKSRVQKQQVFEKELAV 632

Query: 454 HQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLET 513
           ++ ++E I    QE+ E  ++ + NV  R  ++   W+ L   T+++   L    +    
Sbjct: 633 NKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQ---- 688

Query: 514 IDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAH 558
                L+F   A     W+E     +        + E+Q+ +  H
Sbjct: 689 ----QLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKH 729



 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 55/218 (25%), Positives = 96/218 (44%), Gaps = 28/218 (12%)

Query: 317 QKKLEDFRDYRR-KHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEG---------K 366
           +KKL D  DY+  ++   +VQ++   E      +T+L    +      EG          
Sbjct: 601 KKKLADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTT 660

Query: 367 MVSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQ 426
            +S++A  W+ L +A K     L    ++L+        F   A   + W    E  +  
Sbjct: 661 RLSEVASLWEELLEATKQKGTQLHEANQQLQ--------FENNAEDLQRWLEDVEWQVTS 712

Query: 427 KDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKI 486
           +DY    L EV+  LRKH   ES +AA QD+V+ +  +A    E+ + D+ ++  R + +
Sbjct: 713 EDY-GKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESL 771

Query: 487 CDQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAKR 524
             +++ L       +E L   +K L  +D LHL+   R
Sbjct: 772 VCRFEAL-------KEPLATRKKKL--LDLLHLQLICR 800



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 53/253 (20%), Positives = 106/253 (41%), Gaps = 23/253 (9%)

Query: 405  KFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAI 464
            +F Q     E+W   K   +  +DY    L  V+ LL+KH+  E +L AH+  ++ +  +
Sbjct: 1717 QFFQDLDDEESWIEEKLIRVSSQDY-GRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDM 1775

Query: 465  AQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAKR 524
            A++L +        +  R  +  + W++L  L + R   LE      E+++  +L+F + 
Sbjct: 1776 AEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLE------ESLE--YLQFMQN 1827

Query: 525  AAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEV-E 583
            A     W+              ++   QSL+  HE  +      +   Q++ A   ++  
Sbjct: 1828 AEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILN 1887

Query: 584  KVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFA 643
            KV+Q       S N   +  ++ L  K   + + +      L+++ A Q        +F 
Sbjct: 1888 KVLQE-----ESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQ--------EFN 1934

Query: 644  AQANAIGPWIQNK 656
             +A+ +  WI +K
Sbjct: 1935 WKADVVEAWIADK 1947



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 73/353 (20%), Positives = 150/353 (42%), Gaps = 40/353 (11%)

Query: 406 FRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIA 465
           F + +   ++W   +E  L  +D  + SL    ALL+KHE FE    A ++++  +   A
Sbjct: 481 FYRDSEQVDSWMSRQEAFLENEDLGN-SLGSAEALLQKHEDFEEAFTAQEEKIITVDKTA 539

Query: 466 QELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALER---MEKLLETIDQLHLEFA 522
            +L   D++D+ N+      +  + D L      RR  L+    ++KL E  D L     
Sbjct: 540 TKLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDL----- 594

Query: 523 KRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEV 582
                  NW+    + L D      I+ ++S +   + F+  L      +  +  IQ   
Sbjct: 595 ------KNWI-NKKKKLADDEDYKDIQNLKSRVQKQQVFEKELAV---NKTQLENIQKTG 644

Query: 583 EKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQF 642
           +++I+  +   +S N   T  + E+ + W+++ +    +   L E      AN++L  QF
Sbjct: 645 QEMIEGGH--YASDN--VTTRLSEVASLWEELLEATKQKGTQLHE------ANQQL--QF 692

Query: 643 AAQANAIGPWIQNKMEEIARSSIQITGALEDQMNQLKQY---EHNIINYKNNIDKLEGDH 699
              A  +  W+++   ++  +S      L +  N+L+++   E  +   ++ +D L    
Sbjct: 693 ENNAEDLQRWLEDVEWQV--TSEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLA 750

Query: 700 QLIQEALVFDNKHTNYTMEHIRVGWELLLTTIA----RTINEVETQILTRDAK 748
              +E    D+K      E +   +E L   +A    + ++ +  Q++ RD +
Sbjct: 751 AYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTE 803



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 64/334 (19%), Positives = 133/334 (39%), Gaps = 30/334 (8%)

Query: 277  QENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHKPPKVQ 336
            Q+ E L  E+   AS L  W  +    L       ++  +++  +D  D+       +  
Sbjct: 2039 QKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQAD 2098

Query: 337  EKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRL 396
             KC LE     L  +++    P+  P     V  +   W+ L    +  E+ L  E  R 
Sbjct: 2099 FKCLLE-----LDQQIKALGVPS-SPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQ 2152

Query: 397  ERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQD 456
             +   + ++F Q AST   W        L             +LL++    ES L A++ 
Sbjct: 2153 VKNFEMCQEFEQNASTFLQWILETRAYFLD-----------GSLLKETGTLESQLEANKR 2201

Query: 457  RVEQIAAIAQELNEL-----DYHDAVNVNDRCQKI--CDQWDRLGTLTQKRREALERM-- 507
            + ++I A+ ++L ++     +  DA+ ++ +   I    QWD+L  L  + +  LE+   
Sbjct: 2202 KQKEIQAMKRQLTKIVDLGDNLEDALILDIKYSTIGLAQQWDQLYQLGLRMQHNLEQQIQ 2261

Query: 508  -EKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHE---QFKA 563
             + +    ++   EF+     F+  + G +   +    +  +     ++   E   +F+ 
Sbjct: 2262 AKDIKGVSEETLKEFSTIYKHFDENLTGRLTHKEFRSCLRGLNYYLPMVEEDEHEPKFEK 2321

Query: 564  TLPEADGERQSIMAIQNEVEKVIQSYNIRISSSN 597
             L   D  R+  +++++    +I   +  I SS+
Sbjct: 2322 FLDAVDPGRKGYVSLEDYTAFLIDKESENIKSSD 2355



 Score = 38.1 bits (87), Expect = 0.037
 Identities = 53/239 (22%), Positives = 90/239 (37%), Gaps = 35/239 (14%)

Query: 239 KPDERAIMTYVSCFYHAFAGAEQAETAANRICKVLAVNQENERLMEEYERLASEL-LEWI 297
           + D+  I+T ++ ++      +  +  A +   V       E L    ++L   L L+ I
Sbjct: 739 RQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLI 798

Query: 298 RRTIP----WLENRTPEKTMQAMQKKLEDFRDYRRKHK---------PPKVQEKCQLEIN 344
            R       W++   P  T   + K L   +    +H+          P++QE       
Sbjct: 799 CRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQE------- 851

Query: 345 FNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAE 404
                    I+ R   M  EG   ++   +  R++   +  E       RR   LE   +
Sbjct: 852 ---------ITERGNKMVEEGHFAAEDVAS--RVKSLNQNMESLRARAARRQNDLEANVQ 900

Query: 405 KFRQKASTHE--TWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQI 461
             +  A  HE  TW   KE I+   +Y  A      ALL+KHEAF  DL +  D ++ +
Sbjct: 901 FQQYLADLHEAETWIREKEPIVDNTNY-GADEEAAGALLKKHEAFLLDLNSFGDSMKAL 958



 Score = 32.3 bits (72), Expect = 2.0
 Identities = 42/177 (23%), Positives = 69/177 (38%), Gaps = 26/177 (14%)

Query: 496 LTQKRREALERMEKLLETI--------DQLHLEFAKRAAP-FNNWMEGAMEDLQDMFIVH 546
           + ++R+E L R +   E +        D  HL+  KR A     W+   +  L D     
Sbjct: 24  IQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTDKSY-E 82

Query: 547 SIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDE 606
               IQ     H+  +A       E Q+   + +E+EK  +       S++  +   ++E
Sbjct: 83  DPTNIQGKYQKHQSLEA-------EVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEE 135

Query: 607 LRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARS 663
           LR  WD + +L   +   L   L  Q        Q+  +   I  WI +K E IA S
Sbjct: 136 LRHLWDLLLELTLEKGDQLLRALKFQ--------QYVQECADILEWIGDK-EAIATS 183


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.133    0.387 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,905,812
Number of Sequences: 37866
Number of extensions: 1359015
Number of successful extensions: 6088
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 145
Number of HSP's successfully gapped in prelim test: 276
Number of HSP's that attempted gapping in prelim test: 4688
Number of HSP's gapped (non-prelim): 1268
length of query: 894
length of database: 18,247,518
effective HSP length: 111
effective length of query: 783
effective length of database: 14,044,392
effective search space: 10996758936
effective search space used: 10996758936
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.