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Search of human proteins with 4501891
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4501891 actinin, alpha 1 isoform b [Homo sapiens]
(892 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4501891 actinin, alpha 1 isoform b [Homo sapiens] 1806 0.0
gi|194097350 actinin, alpha 1 isoform a [Homo sapiens] 1793 0.0
gi|194097352 actinin, alpha 1 isoform c [Homo sapiens] 1764 0.0
gi|12025678 actinin, alpha 4 [Homo sapiens] 1570 0.0
gi|4501893 actinin, alpha 2 [Homo sapiens] 1455 0.0
gi|4557241 actinin, alpha 3 [Homo sapiens] 1440 0.0
gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo ... 446 e-125
gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo ... 445 e-125
gi|67782321 spectrin beta isoform a [Homo sapiens] 431 e-120
gi|67782319 spectrin beta isoform b [Homo sapiens] 431 e-120
gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens] 427 e-119
gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1 [... 405 e-113
gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens] 344 2e-94
gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ... 288 1e-77
gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ... 288 1e-77
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 242 1e-63
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 242 1e-63
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 242 1e-63
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 242 1e-63
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 242 1e-63
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 242 1e-63
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 242 1e-63
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 242 1e-63
gi|169218211 PREDICTED: similar to plectin 1, partial [Homo sapi... 238 2e-62
gi|221316624 dystonin isoform 4 [Homo sapiens] 236 5e-62
gi|221316622 dystonin isoform 3 [Homo sapiens] 236 5e-62
gi|221316618 dystonin isoform 2 [Homo sapiens] 236 5e-62
gi|34577047 dystonin isoform 1 [Homo sapiens] 236 5e-62
gi|33188445 microfilament and actin filament cross-linker protei... 226 6e-59
gi|115298659 spectrin, alpha, erythrocytic 1 [Homo sapiens] 219 9e-57
>gi|4501891 actinin, alpha 1 isoform b [Homo sapiens]
Length = 892
Score = 1806 bits (4677), Expect = 0.0
Identities = 892/892 (100%), Positives = 892/892 (100%)
Query: 1 MDHYDSQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFR 60
MDHYDSQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFR
Sbjct: 1 MDHYDSQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFR 60
Query: 61 DGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNV 120
DGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNV
Sbjct: 61 DGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNV 120
Query: 121 KMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFC 180
KMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFC
Sbjct: 121 KMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFC 180
Query: 181 ALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMT 240
ALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMT
Sbjct: 181 ALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMT 240
Query: 241 YVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENR 300
YVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENR
Sbjct: 241 YVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENR 300
Query: 301 VPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRM 360
VPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRM
Sbjct: 301 VPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRM 360
Query: 361 VSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQK 420
VSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQK
Sbjct: 361 VSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQK 420
Query: 421 DYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKIC 480
DYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKIC
Sbjct: 421 DYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKIC 480
Query: 481 DQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHT 540
DQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHT
Sbjct: 481 DQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHT 540
Query: 541 IEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEI 600
IEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEI
Sbjct: 541 IEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEI 600
Query: 601 NGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEM 660
NGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEM
Sbjct: 601 NGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEM 660
Query: 661 HGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQL 720
HGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQL
Sbjct: 661 HGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQL 720
Query: 721 LTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGY 780
LTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGY
Sbjct: 721 LTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGY 780
Query: 781 DIGNDPQGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDK 840
DIGNDPQGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDK
Sbjct: 781 DIGNDPQGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDK 840
Query: 841 NYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTALYGESDL 892
NYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTALYGESDL
Sbjct: 841 NYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTALYGESDL 892
>gi|194097350 actinin, alpha 1 isoform a [Homo sapiens]
Length = 914
Score = 1793 bits (4644), Expect = 0.0
Identities = 892/914 (97%), Positives = 892/914 (97%), Gaps = 22/914 (2%)
Query: 1 MDHYDSQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFR 60
MDHYDSQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFR
Sbjct: 1 MDHYDSQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFR 60
Query: 61 DGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNV 120
DGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNV
Sbjct: 61 DGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNV 120
Query: 121 KMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFC 180
KMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFC
Sbjct: 121 KMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFC 180
Query: 181 ALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMT 240
ALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMT
Sbjct: 181 ALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMT 240
Query: 241 YVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENR 300
YVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENR
Sbjct: 241 YVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENR 300
Query: 301 VPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRM 360
VPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRM
Sbjct: 301 VPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRM 360
Query: 361 VSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQK 420
VSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQK
Sbjct: 361 VSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQK 420
Query: 421 DYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKIC 480
DYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKIC
Sbjct: 421 DYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKIC 480
Query: 481 DQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHT 540
DQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHT
Sbjct: 481 DQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHT 540
Query: 541 IEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEI 600
IEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEI
Sbjct: 541 IEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEI 600
Query: 601 NGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEM 660
NGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEM
Sbjct: 601 NGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEM 660
Query: 661 HGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQL 720
HGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQL
Sbjct: 661 HGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQL 720
Query: 721 LTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGY 780
LTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGY
Sbjct: 721 LTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGY 780
Query: 781 DIGNDPQ----------------------GEAEFARIMSIVDPNRLGVVTFQAFIDFMSR 818
DIGNDPQ GEAEFARIMSIVDPNRLGVVTFQAFIDFMSR
Sbjct: 781 DIGNDPQKKTGMMDTDDFRACLISMGYNMGEAEFARIMSIVDPNRLGVVTFQAFIDFMSR 840
Query: 819 ETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALD 878
ETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALD
Sbjct: 841 ETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALD 900
Query: 879 YMSFSTALYGESDL 892
YMSFSTALYGESDL
Sbjct: 901 YMSFSTALYGESDL 914
>gi|194097352 actinin, alpha 1 isoform c [Homo sapiens]
Length = 887
Score = 1764 bits (4570), Expect = 0.0
Identities = 874/892 (97%), Positives = 882/892 (98%), Gaps = 5/892 (0%)
Query: 1 MDHYDSQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFR 60
MDHYDSQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFR
Sbjct: 1 MDHYDSQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFR 60
Query: 61 DGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNV 120
DGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNV
Sbjct: 61 DGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNV 120
Query: 121 KMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFC 180
KMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFC
Sbjct: 121 KMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFC 180
Query: 181 ALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMT 240
ALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMT
Sbjct: 181 ALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMT 240
Query: 241 YVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENR 300
YVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENR
Sbjct: 241 YVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENR 300
Query: 301 VPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRM 360
VPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRM
Sbjct: 301 VPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRM 360
Query: 361 VSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQK 420
VSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQK
Sbjct: 361 VSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQK 420
Query: 421 DYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKIC 480
DYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKIC
Sbjct: 421 DYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKIC 480
Query: 481 DQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHT 540
DQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHT
Sbjct: 481 DQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHT 540
Query: 541 IEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEI 600
IEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEI
Sbjct: 541 IEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEI 600
Query: 601 NGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEM 660
NGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEM
Sbjct: 601 NGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEM 660
Query: 661 HGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQL 720
HGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQL
Sbjct: 661 HGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQL 720
Query: 721 LTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGY 780
LTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDR +G + ++F+ACLIS+GY
Sbjct: 721 LTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRKKTGMMDTDDFRACLISMGY 780
Query: 781 DIGNDPQGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDK 840
++ GEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDK
Sbjct: 781 NM-----GEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDK 835
Query: 841 NYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTALYGESDL 892
NYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTALYGESDL
Sbjct: 836 NYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTALYGESDL 887
>gi|12025678 actinin, alpha 4 [Homo sapiens]
Length = 911
Score = 1570 bits (4065), Expect = 0.0
Identities = 765/882 (86%), Positives = 821/882 (93%)
Query: 11 DYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLE 70
DYM E+DWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENI+EDFRDGLKLMLLLE
Sbjct: 30 DYMAQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLE 89
Query: 71 VISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTI 130
VISGERL KPERGKMRVHKI+NVNKALDFIASKGVKLVSIGAEEIVDGN KMTLGMIWTI
Sbjct: 90 VISGERLPKPERGKMRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTI 149
Query: 131 ILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPEL 190
ILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVN+QNFHISWKDGL F ALIHRHRPEL
Sbjct: 150 ILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPEL 209
Query: 191 IDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFS 250
I+Y KLRKDDP+TNLN AF+VAEKYLDIPKMLDAEDIV TARPDEKAIMTYVSSFYHAFS
Sbjct: 210 IEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFS 269
Query: 251 GAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQ 310
GAQKAETAANRICKVLAVNQENE LMEDYEKLASDLLEWIRRTIPWLE+RVP+ T+ MQ
Sbjct: 270 GAQKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQ 329
Query: 311 QKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGC 370
QKLEDFRDYRR+HKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEG+MVSDINN W
Sbjct: 330 QKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQH 389
Query: 371 LEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEI 430
LEQ EKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAML+ +DYETATLS+I
Sbjct: 390 LEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDI 449
Query: 431 KALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALT 490
KAL++KHEAFESDLAAHQDRVEQIAAIAQELNELDYYDS +VN RCQKICDQWD LG+LT
Sbjct: 450 KALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLT 509
Query: 491 QKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTA 550
RREALE+TEK LE IDQL+LEYAKRAAPFNNWME AMEDLQD FIVHTIEEI+GL +A
Sbjct: 510 HSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISA 569
Query: 551 HEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQL 610
H+QFK+TLPDAD+ER AIL IH E +I ++ H+ ++G+NPYTT+TPQ IN KW+ V+QL
Sbjct: 570 HDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQL 629
Query: 611 VPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSH 670
VP+RD AL EE ++QQ NE LR+QF +QANV+GPWIQTKMEEIGRISIEM+GTLEDQLSH
Sbjct: 630 VPKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTKMEEIGRISIEMNGTLEDQLSH 689
Query: 671 LRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINE 730
L+QYE+SIV+YKP +D LE HQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINE
Sbjct: 690 LKQYERSIVDYKPNLDLLEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINE 749
Query: 731 VENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQGEA 790
VENQILTRDAKGISQEQM EFRASFNHFD+DH G LGPEEFKACLISLGYD+ ND QGEA
Sbjct: 750 VENQILTRDAKGISQEQMQEFRASFNHFDKDHGGALGPEEFKACLISLGYDVENDRQGEA 809
Query: 791 EFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELRR 850
EF RIMS+VDPN G+VTFQAFIDFMSRET DTDTADQV+ASFK+LAGDKN+IT +ELRR
Sbjct: 810 EFNRIMSLVDPNHSGLVTFQAFIDFMSRETTDTDTADQVIASFKVLAGDKNFITAEELRR 869
Query: 851 ELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTALYGESDL 892
ELPPDQAEYCIARMAPY GPD+VPGALDY SFSTALYGESDL
Sbjct: 870 ELPPDQAEYCIARMAPYQGPDAVPGALDYKSFSTALYGESDL 911
>gi|4501893 actinin, alpha 2 [Homo sapiens]
Length = 894
Score = 1455 bits (3766), Expect = 0.0
Identities = 709/883 (80%), Positives = 794/883 (89%), Gaps = 5/883 (0%)
Query: 10 NDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLL 69
++YM EE+WDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFR+GLKLMLLL
Sbjct: 17 DEYMIQEEEWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLL 76
Query: 70 EVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWT 129
EVISGERL KP+RGKMR HKI+NVNKALD+IASKGVKLVSIGAEEIVDGNVKMTLGMIWT
Sbjct: 77 EVISGERLPKPDRGKMRFHKIANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTLGMIWT 136
Query: 130 IILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPE 189
IILRFAIQDISVEETSAKEGLLLWCQRKTAPY+NVNIQNFH SWKDGLG CALIHRHRP+
Sbjct: 137 IILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPD 196
Query: 190 LIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAF 249
LIDY KL KDDP+ N+N A ++AEK+LDIPKMLDAEDIV T +PDE+AIMTYVS FYHAF
Sbjct: 197 LIDYSKLNKDDPIGNINLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAF 256
Query: 250 SGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAM 309
+GA++AETAANRICKVLAVNQENE+LME+YE+LAS+LLEWIRRTIPWLENR PE TM AM
Sbjct: 257 AGAEQAETAANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAM 316
Query: 310 QQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWG 369
Q+KLEDFRDYRR HKPPKVQEKCQLEINFNTLQTKLR+SNRPAFMPSEG+MVSDI AW
Sbjct: 317 QKKLEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQ 376
Query: 370 CLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSE 429
LEQ EKGYEEWLLNEIRRLERL+HLAEKFRQKAS HE W GKE +L QKDYE+A+L+E
Sbjct: 377 RLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTE 436
Query: 430 IKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGAL 489
++ALL+KHEAFESDLAAHQDRVEQIAAIAQELNELDY+D+ +VN RCQKICDQWD LG L
Sbjct: 437 VRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTL 496
Query: 490 TQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTT 549
TQKRREALER EKLLETIDQL+LE+AKRAAPFNNWMEGAMEDLQD FIVH+IEEIQ L T
Sbjct: 497 TQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLIT 556
Query: 550 AHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQ 609
AHEQFKATLP+AD ER +I+ I NEV K++Q+Y++ ++ +NPY+T+T E+ KWD V+Q
Sbjct: 557 AHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQ 616
Query: 610 LVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLS 669
LVP RDQ+L EE ARQ NERLR+QF AQAN IGPWIQ KMEEI R SI++ G LEDQ++
Sbjct: 617 LVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITGALEDQMN 676
Query: 670 HLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTIN 729
L+QYE +I+NYK ID+LEGDHQLIQEAL+FDNKHTNYTMEHIRVGWE LLTTIARTIN
Sbjct: 677 QLKQYEHNIINYKNNIDKLEGDHQLIQEALVFDNKHTNYTMEHIRVGWELLLTTIARTIN 736
Query: 730 EVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQGE 789
EVE QILTRDAKGI+QEQMNEFRASFNHFDR +G + E+F+ACLIS+GYD+ GE
Sbjct: 737 EVETQILTRDAKGITQEQMNEFRASFNHFDRRKNGLMDHEDFRACLISMGYDL-----GE 791
Query: 790 AEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELR 849
AEFARIM++VDPN G VTFQ+FIDFM+RETADTDTA+QV+ASF+ILA DK YI +ELR
Sbjct: 792 AEFARIMTLVDPNGQGTVTFQSFIDFMTRETADTDTAEQVIASFRILASDKPYILAEELR 851
Query: 850 RELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTALYGESDL 892
RELPPDQA+YCI RM Y+GP SVPGALDY +FS+ALYGESDL
Sbjct: 852 RELPPDQAQYCIKRMPAYSGPGSVPGALDYAAFSSALYGESDL 894
>gi|4557241 actinin, alpha 3 [Homo sapiens]
Length = 901
Score = 1440 bits (3727), Expect = 0.0
Identities = 693/882 (78%), Positives = 797/882 (90%), Gaps = 5/882 (0%)
Query: 11 DYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLE 70
+YM+ EEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFR+GLKLMLLLE
Sbjct: 25 EYMEQEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLE 84
Query: 71 VISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTI 130
VISGERL +P++GKMR HKI+NVNKALDFIASKGVKLVSIGAEEIVDGN+KMTLGMIWTI
Sbjct: 85 VISGERLPRPDKGKMRFHKIANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTI 144
Query: 131 ILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPEL 190
ILRFAIQDISVEETSAKEGLLLWCQRKTAPY+NVN+QNFH SWKDGL CALIHRHRP+L
Sbjct: 145 ILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPDL 204
Query: 191 IDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFS 250
IDY KLRKDDP+ NLNTAF+VAEKYLDIPKMLDAEDIV T +PDEKAIMTYVS FYHAF+
Sbjct: 205 IDYAKLRKDDPIGNLNTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFA 264
Query: 251 GAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQ 310
GA++AETAANRICKVLAVNQENE+LME+YEKLAS+LLEWIRRT+PWLENRV E +M AMQ
Sbjct: 265 GAEQAETAANRICKVLAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQ 324
Query: 311 QKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGC 370
+KLEDFRDYRRLHKPP++QEKCQLEINFNTLQTKLRLS+RPAFMPSEG++VSDI NAW
Sbjct: 325 RKLEDFRDYRRLHKPPRIQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRG 384
Query: 371 LEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEI 430
LEQVEKGYE+WLL+EIRRL+RL HLAEKFRQKAS+HEAWT GKE ML Q+DY++A L E+
Sbjct: 385 LEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEV 444
Query: 431 KALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALT 490
+ALL++HEAFESDLAAHQDRVE IAA+AQELNELDY+++ SVN+RCQ ICDQWDNLG LT
Sbjct: 445 RALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLT 504
Query: 491 QKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTA 550
QKRR+ALER EKLLETIDQL LE+A+RAAPFNNW++GA+EDLQD ++VH++EE Q L TA
Sbjct: 505 QKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTA 564
Query: 551 HEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQL 610
H+QFKATLP+AD+ER AI+GI E+ KI QTY + TNPY T++PQ+IN KWD VR+L
Sbjct: 565 HDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKL 624
Query: 611 VPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSH 670
VP RDQ L EE ARQQ NERLR+QF AQAN IGPWIQ K+EE+GR++ + G+LE+Q++
Sbjct: 625 VPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQAKVEEVGRLAAGLAGSLEEQMAG 684
Query: 671 LRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINE 730
LRQ E++I+NYK ID+LEGDHQL+QE+L+FDNKHT Y+MEHIRVGWEQLLT+IARTINE
Sbjct: 685 LRQQEQNIINYKTNIDRLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLLTSIARTINE 744
Query: 731 VENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQGEA 790
VENQ+LTRDAKG+SQEQ+NEFRASFNHFDR +G + P++F+ACLIS+GYD+ GE
Sbjct: 745 VENQVLTRDAKGLSQEQLNEFRASFNHFDRKRNGMMEPDDFRACLISMGYDL-----GEV 799
Query: 791 EFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELRR 850
EFARIM++VDPN GVVTFQAFIDFM+RETA+TDT +QV+ASFKILAGDKNYIT +ELRR
Sbjct: 800 EFARIMTMVDPNAAGVVTFQAFIDFMTRETAETDTTEQVVASFKILAGDKNYITPEELRR 859
Query: 851 ELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTALYGESDL 892
ELP QAEYCI RM PY G + GALDY++FS+ALYGESDL
Sbjct: 860 ELPAKQAEYCIRRMVPYKGSGAPAGALDYVAFSSALYGESDL 901
>gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo
sapiens]
Length = 2155
Score = 446 bits (1146), Expect = e-125
Identities = 279/722 (38%), Positives = 408/722 (56%), Gaps = 54/722 (7%)
Query: 4 YDSQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGL 63
Y Q +Y Q E + + L E Q+KTFT W NSHL + +I ++ D RDG
Sbjct: 17 YTGQVPYNYNQLEGRFKQ---LQDEREAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGR 73
Query: 64 KLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMT 123
L+ LLEV+SGERL KP +G+MR+H + NV+KAL F+ + V L ++G+ +IVDGN ++T
Sbjct: 74 MLIKLLEVLSGERLPKPTKGRMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLT 133
Query: 124 LGMIWTIILRFAIQDISVE------ETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGL 177
LG+IWTIILRF IQDISVE + SAK+ LLLWCQ KTA Y NVNI NF SW+DG+
Sbjct: 134 LGLIWTIILRFQIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGM 193
Query: 178 GFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKA 237
F ALIH+HRP+LID+ KL+K + NL AF++AE++L + K+LD EDI PDEK+
Sbjct: 194 AFNALIHKHRPDLIDFDKLKKSNAHYNLQNAFNLAEQHLGLTKLLDPEDI-SVDHPDEKS 252
Query: 238 IMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWL 297
I+TYV ++YH FS + RI KVL E E+++E YE LASDLLEWI +TI L
Sbjct: 253 IITYVVTYYHYFSKMKALAVEGKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIIL 312
Query: 298 ENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSE 357
NR N++ +QQ+L+ F YR + KPPK EK LE+ T+Q+K+R +N+ +MP E
Sbjct: 313 NNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPRE 372
Query: 358 GRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAML 417
G+++SDIN AW LE+ E E L NE+ R E+L+ LA +F +KA++ E W + ++
Sbjct: 373 GKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLV 432
Query: 418 RQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQ 477
Q ++ L ++A KKHEA E+D+AA+++RV+ + A+A+EL +Y+D + AR
Sbjct: 433 SQDNF-GFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKD 491
Query: 478 KICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWM-EGAMEDLQDTF 536
+ W+ L L + RR+ LE L + ++ +WM E + L +
Sbjct: 492 NVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLY--------IMDWMDEMKVLVLSQDY 543
Query: 537 IVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNE----VSKIVQTYHVNMAGTNPY 592
H + ++ L H TL +AD +GI E V+ Q + + G Y
Sbjct: 544 GKHLL-GVEDLLQKH-----TLVEAD------IGIQAERVRGVNASAQKFATDGEG---Y 588
Query: 593 TTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTK--- 649
PQ I + H+ Q E AR + + RL K F A G WI+ K
Sbjct: 589 KPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEG-WIREKEKI 647
Query: 650 ---------MEEIGRISIEMHGTLEDQLS-HLRQYEKSIVNYKPKIDQLEGDHQLIQEAL 699
+ + R+ + H ED++S +E++I + I + + I+E +
Sbjct: 648 LSSDDYGKDLTSVMRL-LSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERI 706
Query: 700 IF 701
I+
Sbjct: 707 IY 708
Score = 61.6 bits (148), Expect = 3e-09
Identities = 64/271 (23%), Positives = 108/271 (39%), Gaps = 26/271 (9%)
Query: 388 RLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAH 447
RLE L + F + A E W KE +L DY L+ + LL KH AFE +++
Sbjct: 620 RLEESRRLWKFFWEMAE-EEGWIREKEKILSSDDYGK-DLTSVMRLLSKHRAFEDEMSGR 677
Query: 448 QDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETI 507
EQ +++ +++ S + R I +QW NL L+ R++ LE
Sbjct: 678 SGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEA------- 730
Query: 508 DQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLA 567
L ++ A + WM ++ + + + H Q L H K + R
Sbjct: 731 -SLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKH---KDVAEEIANYRPT 786
Query: 568 ILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQH 627
+ +H + S + Q + +P I ++ V +L R QAL + A
Sbjct: 787 LDTLHEQASALPQEH-----AESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLA---- 837
Query: 628 NERLRKQFGAQANVIGPWIQTKMEEIGRISI 658
L K F ++A+ WI K + + + I
Sbjct: 838 ---LYKMF-SEADACELWIDEKEQWLNNMQI 864
Score = 57.4 bits (137), Expect = 6e-08
Identities = 83/424 (19%), Positives = 161/424 (37%), Gaps = 45/424 (10%)
Query: 210 DVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVN 269
DVAE+ + LD +A P E A V K R+ K
Sbjct: 775 DVAEEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRK----- 829
Query: 270 QENEQLMEDYEKLA-SDLLE-WIRRTIPWLEN-RVPENTMHAMQQKLEDFR--DYRRLHK 324
Q + + Y+ + +D E WI WL N ++PE KLED +R
Sbjct: 830 QALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPE--------KLEDLEVIQHRFESL 881
Query: 325 PPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLN 384
P++ + N + +L S P+ + + +N W ++ ++ LL+
Sbjct: 882 EPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQ-DKLNTRWSQFRELVDRKKDALLS 940
Query: 385 EIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDL 444
+ + + + + ++W K ++ L+ + AL +K E DL
Sbjct: 941 ALS--------IQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDL 992
Query: 445 AAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLL 504
A + ++ + A++L + ++ +R +I D W+ + + R +L KL
Sbjct: 993 VAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQ 1052
Query: 505 ETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLP--DAD 562
+ + L F +W+ + + +T+ E + L T HE K + + D
Sbjct: 1053 QFLRDL--------DDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEED 1104
Query: 563 KERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEH 622
+++ +G E+ QT M + Q ++ W+ + ++ R L++ H
Sbjct: 1105 YQKMRDMG---EMVTQGQTDAQYM-----FLRQRLQALDTGWNELHKMWENRQNLLSQSH 1156
Query: 623 ARQQ 626
A QQ
Sbjct: 1157 AYQQ 1160
Score = 55.5 bits (132), Expect = 2e-07
Identities = 76/366 (20%), Positives = 149/366 (40%), Gaps = 40/366 (10%)
Query: 361 VSDINNAWGCL-EQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQ 419
++D+ WG L E+ EK + RRLE H A+++ A+ EAW +E +
Sbjct: 1554 LADLKQLWGLLIEETEKRH--------RRLEEA-HRAQQYYFDAAEAEAWMSEQELYMMS 1604
Query: 420 KDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKI 479
++ S + ++LKKH+ E + + + V Q++ ++ L + +S ++ R K+
Sbjct: 1605 EEKAKDEQSAV-SMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKV 1663
Query: 480 CDQWDNLGALTQKRREALERTEKLLE---TIDQLYLEYAKRAAPFNNWMEGAMEDLQDTF 536
+ L L ++RR L+ +L + +D L A+R + G+ E QD
Sbjct: 1664 DKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREV-----VAGSHELGQD-- 1716
Query: 537 IVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTIT 596
E + L +F + +ER+ +++ +++ + H + A +
Sbjct: 1717 ----YEHVTMLQERFREFARDTGNIGQERVDT--VNHLADELINSGHSDAATIAEW---- 1766
Query: 597 PQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRI 656
+N W + +L+ R Q L + + ++ FG IQ K +++
Sbjct: 1767 KDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGR--------IQDKHKKLPEE 1818
Query: 657 SIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEH-IRV 715
T+E +E I ++ QL+ D +Q A D E+ +
Sbjct: 1819 LGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLE 1878
Query: 716 GWEQLL 721
W+ LL
Sbjct: 1879 AWKSLL 1884
Score = 55.1 bits (131), Expect = 3e-07
Identities = 70/366 (19%), Positives = 156/366 (42%), Gaps = 41/366 (11%)
Query: 364 INNAWGCLEQVEKGYEEWLLNEIRRLERLDH--LAEKFRQKASIHEAWTDGKEAMLRQKD 421
I W LEQ L+ IR+ +RL+ L +F+ A +AW ++ D
Sbjct: 709 IREQWANLEQ---------LSAIRK-KRLEEASLLHQFQADADDIDAWMLDILKIVSSSD 758
Query: 422 YETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICD 481
S ++L+KKH+ ++A ++ ++ + A L + ++ +SP V R I +
Sbjct: 759 VGHDEYST-QSLVKKHKDVAEEIANYRPTLDTLHEQASALPQ-EHAESPDVRGRLSGIEE 816
Query: 482 QWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTI 541
++ + LT+ R++AL+ T L + + A W++ + L + I +
Sbjct: 817 RYKEVAELTRLRKQALQDTLALYKMFSE--------ADACELWIDEKEQWLNNMQIPEKL 868
Query: 542 EEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEIN 601
E+++ + +F++ P+ + + + ++ +++ + H + ++N
Sbjct: 869 EDLEVI---QHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPS----EKEIKAQQDKLN 921
Query: 602 GKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTK---MEEIGRISI 658
+W R+LV R+ AL + Q ++ + N WI+ K +E +
Sbjct: 922 TRWSQFRELVDRKKDALLSALSIQNYH--------LECNETKSWIREKTKVIESTQDLGN 973
Query: 659 EMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWE 718
++ G + Q L E+ +V + K+ L+ + + ++ + + I WE
Sbjct: 974 DLAGVMALQ-RKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWE 1032
Query: 719 QLLTTI 724
++ TT+
Sbjct: 1033 EMKTTL 1038
Score = 43.1 bits (100), Expect = 0.001
Identities = 41/189 (21%), Positives = 86/189 (45%), Gaps = 18/189 (9%)
Query: 385 EIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETAT--LSEIKALLKKHEAFES 442
E RR+ +D +KFR + + + E ++RQ + + +S ++ L+ H+ ++
Sbjct: 1888 ESRRVRLVD-TGDKFRFFSMVRDLML-WMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKA 1945
Query: 443 DLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEK 502
++ A D + + L +Y S + + L LT+KR+E +++ E
Sbjct: 1946 EIDARNDSFTTCIELGKSLLARKHYASEEIK----------EKLLQLTEKRKEMIDKWED 1995
Query: 503 LLETIDQLYLE---YAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLP 559
E + +L LE +++ A+ W+ G L I +++E++ L HE F+ +
Sbjct: 1996 RWEWL-RLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAA 2054
Query: 560 DADKERLAI 568
D+ A+
Sbjct: 2055 TWDERFSAL 2063
Score = 40.0 bits (92), Expect = 0.010
Identities = 24/79 (30%), Positives = 40/79 (50%), Gaps = 7/79 (8%)
Query: 372 EQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIK 431
E ++K + W RL +F + AS+ EAW G+E L ++ + + E++
Sbjct: 1988 EMIDKWEDRW------EWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQS-VDEVE 2040
Query: 432 ALLKKHEAFESDLAAHQDR 450
L+K+HEAFE A +R
Sbjct: 2041 KLIKRHEAFEKSAATWDER 2059
Score = 38.5 bits (88), Expect = 0.028
Identities = 19/68 (27%), Positives = 36/68 (52%), Gaps = 1/68 (1%)
Query: 396 AEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIA 455
AE F Q + + W G E+ ++ DY L+ + LLKK + E+ + + +E++
Sbjct: 1369 AELFTQSCADLDKWLHGLESQIQSDDYGK-DLTSVNILLKKQQMLENQMEVRKKEIEELQ 1427
Query: 456 AIAQELNE 463
+ AQ L++
Sbjct: 1428 SQAQALSQ 1435
Score = 36.6 bits (83), Expect = 0.11
Identities = 33/157 (21%), Positives = 65/157 (41%), Gaps = 9/157 (5%)
Query: 427 LSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQEL-NELDYYDSPSVNARCQKICDQWDN 485
L ++ L+KK++ + ++ HQ R++ I +Q + + + ++ R + W
Sbjct: 1504 LQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGL 1563
Query: 486 LGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNN---WMEGAMEDLQDTFIVHTIE 542
L T+KR LE + Q Y + A+ A + +M + + V ++
Sbjct: 1564 LIEETEKRHRRLEEAHR----AQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLK 1619
Query: 543 EIQGLTTAHEQFKATLPDADK-ERLAILGIHNEVSKI 578
+ Q L A E + T+ K R + H E +I
Sbjct: 1620 KHQILEQAVEDYAETVHQLSKTSRALVADSHPESERI 1656
Score = 33.1 bits (74), Expect = 1.2
Identities = 29/137 (21%), Positives = 56/137 (40%), Gaps = 10/137 (7%)
Query: 397 EKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAA 456
+KF Q W + K + Y+ A K L KH+AF ++LA++++ +++I
Sbjct: 1265 QKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWL--KHQAFMAELASNKEWLDKIEK 1322
Query: 457 IAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAK 516
+L V + + W+ L + TQ + + L K +L + +
Sbjct: 1323 EGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKA-----EL---FTQ 1374
Query: 517 RAAPFNNWMEGAMEDLQ 533
A + W+ G +Q
Sbjct: 1375 SCADLDKWLHGLESQIQ 1391
>gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo
sapiens]
Length = 2364
Score = 445 bits (1145), Expect = e-125
Identities = 273/696 (39%), Positives = 399/696 (57%), Gaps = 51/696 (7%)
Query: 30 EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHK 89
E Q+KTFT W NSHL + +I ++ D RDG L+ LLEV+SGERL KP +G+MR+H
Sbjct: 53 EAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKPTKGRMRIHC 112
Query: 90 ISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVE------E 143
+ NV+KAL F+ + V L ++G+ +IVDGN ++TLG+IWTIILRF IQDISVE +
Sbjct: 113 LENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDNKEK 172
Query: 144 TSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLT 203
SAK+ LLLWCQ KTA Y NVNI NF SW+DG+ F ALIH+HRP+LID+ KL+K +
Sbjct: 173 KSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSNAHY 232
Query: 204 NLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRIC 263
NL AF++AE++L + K+LD EDI PDEK+I+TYV ++YH FS + RI
Sbjct: 233 NLQNAFNLAEQHLGLTKLLDPEDI-SVDHPDEKSIITYVVTYYHYFSKMKALAVEGKRIG 291
Query: 264 KVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLH 323
KVL E E+++E YE LASDLLEWI +TI L NR N++ +QQ+L+ F YR +
Sbjct: 292 KVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVE 351
Query: 324 KPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLL 383
KPPK EK LE+ T+Q+K+R +N+ +MP EG+++SDIN AW LE+ E E L
Sbjct: 352 KPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALR 411
Query: 384 NEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESD 443
NE+ R E+L+ LA +F +KA++ E W + ++ Q ++ L ++A KKHEA E+D
Sbjct: 412 NELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNF-GFDLPAVEAATKKHEAIETD 470
Query: 444 LAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKL 503
+AA+++RV+ + A+A+EL +Y+D + AR + W+ L L + RR+ LE L
Sbjct: 471 IAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGL 530
Query: 504 LETIDQLYLEYAKRAAPFNNWM-EGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDAD 562
+ ++ +WM E + L + H + ++ L H TL +AD
Sbjct: 531 QKIFQEMLY--------IMDWMDEMKVLVLSQDYGKHLL-GVEDLLQKH-----TLVEAD 576
Query: 563 KERLAILGIHNE----VSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQAL 618
+GI E V+ Q + + G Y PQ I + H+ Q
Sbjct: 577 ------IGIQAERVRGVNASAQKFATDGEG---YKPCDPQVIRDRVAHMEFCYQELCQLA 627
Query: 619 TEEHARQQHNERLRKQFGAQANVIGPWIQTK------------MEEIGRISIEMHGTLED 666
E AR + + RL K F A G WI+ K + + R+ + H ED
Sbjct: 628 AERRARLEESRRLWKFFWEMAEEEG-WIREKEKILSSDDYGKDLTSVMRL-LSKHRAFED 685
Query: 667 QLS-HLRQYEKSIVNYKPKIDQLEGDHQLIQEALIF 701
++S +E++I + I + + I+E +I+
Sbjct: 686 EMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIY 721
Score = 61.6 bits (148), Expect = 3e-09
Identities = 64/271 (23%), Positives = 108/271 (39%), Gaps = 26/271 (9%)
Query: 388 RLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAH 447
RLE L + F + A E W KE +L DY L+ + LL KH AFE +++
Sbjct: 633 RLEESRRLWKFFWEMAE-EEGWIREKEKILSSDDYGK-DLTSVMRLLSKHRAFEDEMSGR 690
Query: 448 QDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETI 507
EQ +++ +++ S + R I +QW NL L+ R++ LE
Sbjct: 691 SGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEA------- 743
Query: 508 DQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLA 567
L ++ A + WM ++ + + + H Q L H K + R
Sbjct: 744 -SLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKH---KDVAEEIANYRPT 799
Query: 568 ILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQH 627
+ +H + S + Q + +P I ++ V +L R QAL + A
Sbjct: 800 LDTLHEQASALPQEH-----AESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLA---- 850
Query: 628 NERLRKQFGAQANVIGPWIQTKMEEIGRISI 658
L K F ++A+ WI K + + + I
Sbjct: 851 ---LYKMF-SEADACELWIDEKEQWLNNMQI 877
Score = 57.4 bits (137), Expect = 6e-08
Identities = 83/424 (19%), Positives = 161/424 (37%), Gaps = 45/424 (10%)
Query: 210 DVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVN 269
DVAE+ + LD +A P E A V K R+ K
Sbjct: 788 DVAEEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRK----- 842
Query: 270 QENEQLMEDYEKLA-SDLLE-WIRRTIPWLEN-RVPENTMHAMQQKLEDFR--DYRRLHK 324
Q + + Y+ + +D E WI WL N ++PE KLED +R
Sbjct: 843 QALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPE--------KLEDLEVIQHRFESL 894
Query: 325 PPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLN 384
P++ + N + +L S P+ + + +N W ++ ++ LL+
Sbjct: 895 EPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQ-DKLNTRWSQFRELVDRKKDALLS 953
Query: 385 EIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDL 444
+ + + + + ++W K ++ L+ + AL +K E DL
Sbjct: 954 ALS--------IQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDL 1005
Query: 445 AAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLL 504
A + ++ + A++L + ++ +R +I D W+ + + R +L KL
Sbjct: 1006 VAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQ 1065
Query: 505 ETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLP--DAD 562
+ + L F +W+ + + +T+ E + L T HE K + + D
Sbjct: 1066 QFLRDL--------DDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEED 1117
Query: 563 KERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEH 622
+++ +G E+ QT M + Q ++ W+ + ++ R L++ H
Sbjct: 1118 YQKMRDMG---EMVTQGQTDAQYM-----FLRQRLQALDTGWNELHKMWENRQNLLSQSH 1169
Query: 623 ARQQ 626
A QQ
Sbjct: 1170 AYQQ 1173
Score = 55.5 bits (132), Expect = 2e-07
Identities = 76/366 (20%), Positives = 149/366 (40%), Gaps = 40/366 (10%)
Query: 361 VSDINNAWGCL-EQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQ 419
++D+ WG L E+ EK + RRLE H A+++ A+ EAW +E +
Sbjct: 1567 LADLKQLWGLLIEETEKRH--------RRLEEA-HRAQQYYFDAAEAEAWMSEQELYMMS 1617
Query: 420 KDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKI 479
++ S + ++LKKH+ E + + + V Q++ ++ L + +S ++ R K+
Sbjct: 1618 EEKAKDEQSAV-SMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKV 1676
Query: 480 CDQWDNLGALTQKRREALERTEKLLE---TIDQLYLEYAKRAAPFNNWMEGAMEDLQDTF 536
+ L L ++RR L+ +L + +D L A+R + G+ E QD
Sbjct: 1677 DKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREV-----VAGSHELGQD-- 1729
Query: 537 IVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTIT 596
E + L +F + +ER+ +++ +++ + H + A +
Sbjct: 1730 ----YEHVTMLQERFREFARDTGNIGQERVDT--VNHLADELINSGHSDAATIAEW---- 1779
Query: 597 PQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRI 656
+N W + +L+ R Q L + + ++ FG IQ K +++
Sbjct: 1780 KDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGR--------IQDKHKKLPEE 1831
Query: 657 SIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEH-IRV 715
T+E +E I ++ QL+ D +Q A D E+ +
Sbjct: 1832 LGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLE 1891
Query: 716 GWEQLL 721
W+ LL
Sbjct: 1892 AWKSLL 1897
Score = 55.1 bits (131), Expect = 3e-07
Identities = 70/366 (19%), Positives = 156/366 (42%), Gaps = 41/366 (11%)
Query: 364 INNAWGCLEQVEKGYEEWLLNEIRRLERLDH--LAEKFRQKASIHEAWTDGKEAMLRQKD 421
I W LEQ L+ IR+ +RL+ L +F+ A +AW ++ D
Sbjct: 722 IREQWANLEQ---------LSAIRK-KRLEEASLLHQFQADADDIDAWMLDILKIVSSSD 771
Query: 422 YETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICD 481
S ++L+KKH+ ++A ++ ++ + A L + ++ +SP V R I +
Sbjct: 772 VGHDEYST-QSLVKKHKDVAEEIANYRPTLDTLHEQASALPQ-EHAESPDVRGRLSGIEE 829
Query: 482 QWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTI 541
++ + LT+ R++AL+ T L + + A W++ + L + I +
Sbjct: 830 RYKEVAELTRLRKQALQDTLALYKMFSE--------ADACELWIDEKEQWLNNMQIPEKL 881
Query: 542 EEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEIN 601
E+++ + +F++ P+ + + + ++ +++ + H + ++N
Sbjct: 882 EDLEVI---QHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPS----EKEIKAQQDKLN 934
Query: 602 GKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTK---MEEIGRISI 658
+W R+LV R+ AL + Q ++ + N WI+ K +E +
Sbjct: 935 TRWSQFRELVDRKKDALLSALSIQNYH--------LECNETKSWIREKTKVIESTQDLGN 986
Query: 659 EMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWE 718
++ G + Q L E+ +V + K+ L+ + + ++ + + I WE
Sbjct: 987 DLAGVMALQ-RKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWE 1045
Query: 719 QLLTTI 724
++ TT+
Sbjct: 1046 EMKTTL 1051
Score = 43.1 bits (100), Expect = 0.001
Identities = 41/189 (21%), Positives = 86/189 (45%), Gaps = 18/189 (9%)
Query: 385 EIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETAT--LSEIKALLKKHEAFES 442
E RR+ +D +KFR + + + E ++RQ + + +S ++ L+ H+ ++
Sbjct: 1901 ESRRVRLVD-TGDKFRFFSMVRDLML-WMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKA 1958
Query: 443 DLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEK 502
++ A D + + L +Y S + + L LT+KR+E +++ E
Sbjct: 1959 EIDARNDSFTTCIELGKSLLARKHYASEEIK----------EKLLQLTEKRKEMIDKWED 2008
Query: 503 LLETIDQLYLE---YAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLP 559
E + +L LE +++ A+ W+ G L I +++E++ L HE F+ +
Sbjct: 2009 RWEWL-RLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAA 2067
Query: 560 DADKERLAI 568
D+ A+
Sbjct: 2068 TWDERFSAL 2076
Score = 40.4 bits (93), Expect = 0.007
Identities = 35/153 (22%), Positives = 66/153 (43%), Gaps = 23/153 (15%)
Query: 372 EQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIK 431
E ++K + W RL +F + AS+ EAW G+E L ++ + + E++
Sbjct: 2001 EMIDKWEDRW------EWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQS-VDEVE 2053
Query: 432 ALLKKHEAFESDLAAHQDRVE--------QIAAIAQELNELDYYDSPSVNARCQKICD-- 481
L+K+HEAFE A +R ++ + ++ E + P K+ +
Sbjct: 2054 KLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRPPSPEPSTKVSEEA 2113
Query: 482 ----QWDNLGA--LTQKRREALERTEKLLETID 508
QWD ++Q A + + ++ ET+D
Sbjct: 2114 ESQQQWDTSKGEQVSQNGLPAEQGSPRMAETVD 2146
Score = 38.5 bits (88), Expect = 0.028
Identities = 19/68 (27%), Positives = 36/68 (52%), Gaps = 1/68 (1%)
Query: 396 AEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIA 455
AE F Q + + W G E+ ++ DY L+ + LLKK + E+ + + +E++
Sbjct: 1382 AELFTQSCADLDKWLHGLESQIQSDDYGK-DLTSVNILLKKQQMLENQMEVRKKEIEELQ 1440
Query: 456 AIAQELNE 463
+ AQ L++
Sbjct: 1441 SQAQALSQ 1448
Score = 36.6 bits (83), Expect = 0.11
Identities = 33/157 (21%), Positives = 65/157 (41%), Gaps = 9/157 (5%)
Query: 427 LSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQEL-NELDYYDSPSVNARCQKICDQWDN 485
L ++ L+KK++ + ++ HQ R++ I +Q + + + ++ R + W
Sbjct: 1517 LQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGL 1576
Query: 486 LGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNN---WMEGAMEDLQDTFIVHTIE 542
L T+KR LE + Q Y + A+ A + +M + + V ++
Sbjct: 1577 LIEETEKRHRRLEEAHR----AQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLK 1632
Query: 543 EIQGLTTAHEQFKATLPDADK-ERLAILGIHNEVSKI 578
+ Q L A E + T+ K R + H E +I
Sbjct: 1633 KHQILEQAVEDYAETVHQLSKTSRALVADSHPESERI 1669
Score = 33.1 bits (74), Expect = 1.2
Identities = 29/137 (21%), Positives = 56/137 (40%), Gaps = 10/137 (7%)
Query: 397 EKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAA 456
+KF Q W + K + Y+ A K L KH+AF ++LA++++ +++I
Sbjct: 1278 QKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWL--KHQAFMAELASNKEWLDKIEK 1335
Query: 457 IAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAK 516
+L V + + W+ L + TQ + + L K +L + +
Sbjct: 1336 EGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKA-----EL---FTQ 1387
Query: 517 RAAPFNNWMEGAMEDLQ 533
A + W+ G +Q
Sbjct: 1388 SCADLDKWLHGLESQIQ 1404
>gi|67782321 spectrin beta isoform a [Homo sapiens]
Length = 2328
Score = 431 bits (1107), Expect = e-120
Identities = 260/715 (36%), Positives = 390/715 (54%), Gaps = 34/715 (4%)
Query: 30 EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHK 89
E Q+KTFT W NSHL + +I ++ +D RDG L+ LLEV+SGE L KP +GKMR+H
Sbjct: 53 EVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMRIHC 112
Query: 90 ISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISV------EE 143
+ NV+KAL F+ + V L ++G+ +IVDGN ++ LG+IWTIILRF IQDI V E
Sbjct: 113 LENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEGRET 172
Query: 144 TSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLT 203
SAK+ LLLWCQ KTA Y +VN+ NF SWKDGL F ALIH+HRP+LID+ KL+ +
Sbjct: 173 RSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSNARH 232
Query: 204 NLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRIC 263
NL AF+VAE+ L I +LD ED+ T PDEK+I+TYV +FYH FS + R+
Sbjct: 233 NLEHAFNVAERQLGIIPLLDPEDVF-TENPDEKSIITYVVAFYHYFSKMKVLAVEGKRVG 291
Query: 264 KVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLH 323
KV+ E E+++E Y LASDLL WI +TI L +R N++ +QQ+L+ F YR +
Sbjct: 292 KVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVE 351
Query: 324 KPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLL 383
KPPK QEK LE+ T+Q+++R +N+ + P +G++VSDIN AW LE+ E E L
Sbjct: 352 KPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALR 411
Query: 384 NEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESD 443
NE+ R E+L+ LA +F +KA++ E W + ++ Q ++ L+ ++A KKHEA E+D
Sbjct: 412 NELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNF-GYDLAAVEAAKKKHEAIETD 470
Query: 444 LAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKL 503
AA+++RV + +AQEL + +Y+D + AR I W L L Q RR+ LE T L
Sbjct: 471 TAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLAL 530
Query: 504 LETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADK 563
+ + +WM+ L + E++ L H+ L +AD
Sbjct: 531 QKLFQDMLHSI--------DWMDEIKAHLLSAEFGKHLLEVEDLLQKHK-----LMEAD- 576
Query: 564 ERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHA 623
+ I + K + + Y PQ I + H+ Q A
Sbjct: 577 -----IAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKA 631
Query: 624 RQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISI--EMHGTLEDQLSHLRQYEKSIVNY 681
+ + ++RL K F + + WI+ K + + ++ L Q H + +E +
Sbjct: 632 QLEQSKRLWKFFW-EMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKH-KAFEDELRGL 689
Query: 682 KPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIA---RTINEVEN 733
++Q+ + + F + ++ + W+QL A + + + EN
Sbjct: 690 DAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAEN 744
Score = 55.8 bits (133), Expect = 2e-07
Identities = 90/467 (19%), Positives = 177/467 (37%), Gaps = 54/467 (11%)
Query: 280 EKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFN 339
+KL D+L +I W++ + L + D + HK + Q +
Sbjct: 531 QKLFQDMLH----SIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKA 586
Query: 340 TLQTKLRLSNRPAFMPSEGRMVSD-INNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEK 398
L+ + + P + +++ D I++ C E++ +LE+ L K
Sbjct: 587 ITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSN----MAAGRKAQLEQSKRLW-K 641
Query: 399 FRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIA 458
F + E+W KE + DY L+ + L +KH+AFE +L +EQI A
Sbjct: 642 FFWEMDEAESWIKEKEQIYSSLDYGK-DLTSVLILQRKHKAFEDELRGLDAHLEQIFQEA 700
Query: 459 QELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRA 518
+ + P + AR +++ QWD L L ++ L+ E + ++ A
Sbjct: 701 HGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAEN--------FFQFQGDA 752
Query: 519 APFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKI 578
W++ A L + + L H+ F L + ++ R G+ + +
Sbjct: 753 DDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDF---LEELEESR----GVMEHLEQQ 805
Query: 579 VQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRD---QALTEEHARQQHNER---LR 632
Q + P+E D +L R+ Q + + RQQ + L
Sbjct: 806 AQGF--------------PEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLY 851
Query: 633 KQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDH 692
FG + + W+ K + + +EM TLED +++ K + Q++G +
Sbjct: 852 TVFG-ETDACELWMGEKEKWLA--EMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVN 908
Query: 693 QLIQEALIFD----NKHTNYTMEHIRVGWEQLLTTIARTINEVENQI 735
L +L+ ++ +H+ W+ T ++ V++ +
Sbjct: 909 -LAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSAL 954
Score = 50.8 bits (120), Expect = 5e-06
Identities = 71/331 (21%), Positives = 138/331 (41%), Gaps = 39/331 (11%)
Query: 398 KFRQKASIHEAWTDGKEAMLRQKDY---ETATLSEIKALLKKHEAFESDLAAHQDRVEQI 454
+F+ A +AW +L +D E AT +AL KKH+ F +L + +E +
Sbjct: 747 QFQGDADDLKAWLQDAHRLLSGEDVGQDEGAT----RALGKKHKDFLEELEESRGVMEHL 802
Query: 455 AAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEY 514
AQ E ++ DSP V R Q + + + + A R++ L+ E +D LY +
Sbjct: 803 EQQAQGFPE-EFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQ------EALD-LYTVF 854
Query: 515 AKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLA--ILGIH 572
+ A WM + L + + T+E+++ + Q + + D + + L I G++
Sbjct: 855 GETDA-CELWMGEKEKWLAEMEMPDTLEDLEVV-----QHRFDILDQEMKTLMTQIDGVN 908
Query: 573 NEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLR 632
+ +V++ H Y +N +W + LV R +A+ + A + HN
Sbjct: 909 LAANSLVESGHPRSREVKQYQ----DHLNTRWQAFQTLVSERREAV--DSALRVHN---- 958
Query: 633 KQFGAQANVIGPWIQTK---MEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLE 689
+ WI K +E + ++ G + Q L E+ + + ++D LE
Sbjct: 959 --YCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRK-LSGLERDVAAIQARVDALE 1015
Query: 690 GDHQLIQEALIFDNKHTNYTMEHIRVGWEQL 720
+ Q + ++ + +H+ W+ L
Sbjct: 1016 RESQQLMDSHPEQKEDIGQRQKHLEELWQGL 1046
Score = 48.5 bits (114), Expect = 3e-05
Identities = 58/272 (21%), Positives = 105/272 (38%), Gaps = 45/272 (16%)
Query: 268 VNQENEQLMED---YEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHK 324
++ E +QLM++ + L S LE + R L+ E T H + D R
Sbjct: 1332 IDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLR------- 1384
Query: 325 PPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLE-----------Q 373
+Q L + ++ +LR + + S RM++ + + Q
Sbjct: 1385 ---LQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQ 1441
Query: 374 V----EKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEA------------WTDGKEAML 417
V E+G + L E R L+ L+ L + +Q S W + + +
Sbjct: 1442 VPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLA 1501
Query: 418 RQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQ 477
+ DY T L ++ +KK++ ++++ H RVE + Q+L E D + R
Sbjct: 1502 QSADYGT-NLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLG 1560
Query: 478 KICDQWDNL----GALTQKRREALERTEKLLE 505
+ WD L Q+ R+A E + L+
Sbjct: 1561 HLQSSWDRLREAAAGRLQRLRDANEAQQYYLD 1592
Score = 48.1 bits (113), Expect = 4e-05
Identities = 66/269 (24%), Positives = 107/269 (39%), Gaps = 36/269 (13%)
Query: 248 AFSGAQKAETAANRICKVLAVNQ--------ENEQLMEDYEK-----LASDLLEWIRRTI 294
A++G +KAE N+ +V A Q QL++ +K +A DLL W+ I
Sbjct: 1865 AYAG-EKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESII 1923
Query: 295 PWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFM 354
+E + E RD + K + EI + L + +
Sbjct: 1924 RQIETQ-------------ERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLL 1970
Query: 355 PSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAE--KFRQKASIHEAWTDG 412
+ + +I L+QV +E R ERL L E +F + AS+ EAW
Sbjct: 1971 QRQHQASEEIREK---LQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIA 2027
Query: 413 KEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQI-AAIAQELNELDYYDSPS 471
+E L D+ T+ ++ L+K+HEAFE A+ +R + EL E + P+
Sbjct: 2028 QEPYLASGDFGH-TVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELKERQIAERPA 2086
Query: 472 VNARCQKICDQWDNLGALTQKRREALERT 500
Q+ ++ + G A ERT
Sbjct: 2087 EETGPQE--EEGETAGEAPVSHHAATERT 2113
Score = 38.5 bits (88), Expect = 0.028
Identities = 35/135 (25%), Positives = 59/135 (43%), Gaps = 11/135 (8%)
Query: 397 EKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAA 456
+ F Q W + K + Y+ A K L KH+AF ++LA+H+ +E I A
Sbjct: 1277 QNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWL--KHQAFVAELASHEGWLENIDA 1334
Query: 457 IAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAK 516
++L + + V+ + + + WD L A T+++ + L L L+
Sbjct: 1335 EGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARS-----SDLRLQ--- 1386
Query: 517 RAAPFNNWMEGAMED 531
A N W+ AMED
Sbjct: 1387 THADLNKWI-SAMED 1400
Score = 37.4 bits (85), Expect = 0.063
Identities = 59/311 (18%), Positives = 120/311 (38%), Gaps = 50/311 (16%)
Query: 409 WTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYD 468
W K ++ L+ I A+ +K E D+AA Q RV+ + +Q+L +
Sbjct: 969 WITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQ 1028
Query: 469 SPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGA 528
+ R + + + W L +++L+ E LL + QL +
Sbjct: 1029 KEDIGQRQKHLEELWQGL-------QQSLQGQEDLLGEVSQL---------------QAF 1066
Query: 529 MEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYH----- 583
++DL D I A E +LP+A++ GI +E+ +Y
Sbjct: 1067 LQDLDD---FQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKES 1123
Query: 584 ---VNMAGTNPYTTITPQEING---KWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGA 637
V T+P + Q + G W+ + ++ R L + Q+ + ++
Sbjct: 1124 GEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAI 1183
Query: 638 QANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEK---SIVNYKPKI-DQLEGDHQ 693
+N +E +E +LE + +R++E S+ N + K+ ++ ++
Sbjct: 1184 LSN----------QEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNK 1233
Query: 694 LIQEALIFDNK 704
L+ E ++ +K
Sbjct: 1234 LVAEGNLYSDK 1244
Score = 36.2 bits (82), Expect = 0.14
Identities = 33/173 (19%), Positives = 74/173 (42%), Gaps = 16/173 (9%)
Query: 387 RRLERLDHLAEKFRQKASIHE--AWTDGKEAMLRQKDYETAT--LSEIKALLKKHEAFES 442
RR + +D A+KFR + + +W E+++RQ + + +S ++ L+K H+ +
Sbjct: 1895 RRTQLVD-TADKFRFFSMARDLLSWM---ESIIRQIETQERPRDVSSVELLMKYHQGINA 1950
Query: 443 DLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEK 502
++ + + L + + S + + Q++ + + +K ER
Sbjct: 1951 EIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMN---EKWEARWERLRM 2007
Query: 503 LLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFK 555
LLE ++++ A+ W+ L HT++ ++ L HE F+
Sbjct: 2008 LLEVC-----QFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFE 2055
>gi|67782319 spectrin beta isoform b [Homo sapiens]
Length = 2137
Score = 431 bits (1107), Expect = e-120
Identities = 260/715 (36%), Positives = 390/715 (54%), Gaps = 34/715 (4%)
Query: 30 EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHK 89
E Q+KTFT W NSHL + +I ++ +D RDG L+ LLEV+SGE L KP +GKMR+H
Sbjct: 53 EVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMRIHC 112
Query: 90 ISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISV------EE 143
+ NV+KAL F+ + V L ++G+ +IVDGN ++ LG+IWTIILRF IQDI V E
Sbjct: 113 LENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEGRET 172
Query: 144 TSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLT 203
SAK+ LLLWCQ KTA Y +VN+ NF SWKDGL F ALIH+HRP+LID+ KL+ +
Sbjct: 173 RSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSNARH 232
Query: 204 NLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRIC 263
NL AF+VAE+ L I +LD ED+ T PDEK+I+TYV +FYH FS + R+
Sbjct: 233 NLEHAFNVAERQLGIIPLLDPEDVF-TENPDEKSIITYVVAFYHYFSKMKVLAVEGKRVG 291
Query: 264 KVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLH 323
KV+ E E+++E Y LASDLL WI +TI L +R N++ +QQ+L+ F YR +
Sbjct: 292 KVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVE 351
Query: 324 KPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLL 383
KPPK QEK LE+ T+Q+++R +N+ + P +G++VSDIN AW LE+ E E L
Sbjct: 352 KPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALR 411
Query: 384 NEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESD 443
NE+ R E+L+ LA +F +KA++ E W + ++ Q ++ L+ ++A KKHEA E+D
Sbjct: 412 NELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNF-GYDLAAVEAAKKKHEAIETD 470
Query: 444 LAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKL 503
AA+++RV + +AQEL + +Y+D + AR I W L L Q RR+ LE T L
Sbjct: 471 TAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLAL 530
Query: 504 LETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADK 563
+ + +WM+ L + E++ L H+ L +AD
Sbjct: 531 QKLFQDMLHSI--------DWMDEIKAHLLSAEFGKHLLEVEDLLQKHK-----LMEAD- 576
Query: 564 ERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHA 623
+ I + K + + Y PQ I + H+ Q A
Sbjct: 577 -----IAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKA 631
Query: 624 RQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISI--EMHGTLEDQLSHLRQYEKSIVNY 681
+ + ++RL K F + + WI+ K + + ++ L Q H + +E +
Sbjct: 632 QLEQSKRLWKFFW-EMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKH-KAFEDELRGL 689
Query: 682 KPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIA---RTINEVEN 733
++Q+ + + F + ++ + W+QL A + + + EN
Sbjct: 690 DAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAEN 744
Score = 55.8 bits (133), Expect = 2e-07
Identities = 90/467 (19%), Positives = 177/467 (37%), Gaps = 54/467 (11%)
Query: 280 EKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFN 339
+KL D+L +I W++ + L + D + HK + Q +
Sbjct: 531 QKLFQDMLH----SIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKA 586
Query: 340 TLQTKLRLSNRPAFMPSEGRMVSD-INNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEK 398
L+ + + P + +++ D I++ C E++ +LE+ L K
Sbjct: 587 ITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSN----MAAGRKAQLEQSKRLW-K 641
Query: 399 FRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIA 458
F + E+W KE + DY L+ + L +KH+AFE +L +EQI A
Sbjct: 642 FFWEMDEAESWIKEKEQIYSSLDYGK-DLTSVLILQRKHKAFEDELRGLDAHLEQIFQEA 700
Query: 459 QELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRA 518
+ + P + AR +++ QWD L L ++ L+ E + ++ A
Sbjct: 701 HGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAEN--------FFQFQGDA 752
Query: 519 APFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKI 578
W++ A L + + L H+ F L + ++ R G+ + +
Sbjct: 753 DDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDF---LEELEESR----GVMEHLEQQ 805
Query: 579 VQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRD---QALTEEHARQQHNER---LR 632
Q + P+E D +L R+ Q + + RQQ + L
Sbjct: 806 AQGF--------------PEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLY 851
Query: 633 KQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDH 692
FG + + W+ K + + +EM TLED +++ K + Q++G +
Sbjct: 852 TVFG-ETDACELWMGEKEKWLA--EMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVN 908
Query: 693 QLIQEALIFD----NKHTNYTMEHIRVGWEQLLTTIARTINEVENQI 735
L +L+ ++ +H+ W+ T ++ V++ +
Sbjct: 909 -LAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSAL 954
Score = 50.8 bits (120), Expect = 5e-06
Identities = 71/331 (21%), Positives = 138/331 (41%), Gaps = 39/331 (11%)
Query: 398 KFRQKASIHEAWTDGKEAMLRQKDY---ETATLSEIKALLKKHEAFESDLAAHQDRVEQI 454
+F+ A +AW +L +D E AT +AL KKH+ F +L + +E +
Sbjct: 747 QFQGDADDLKAWLQDAHRLLSGEDVGQDEGAT----RALGKKHKDFLEELEESRGVMEHL 802
Query: 455 AAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEY 514
AQ E ++ DSP V R Q + + + + A R++ L+ E +D LY +
Sbjct: 803 EQQAQGFPE-EFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQ------EALD-LYTVF 854
Query: 515 AKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLA--ILGIH 572
+ A WM + L + + T+E+++ + Q + + D + + L I G++
Sbjct: 855 GETDA-CELWMGEKEKWLAEMEMPDTLEDLEVV-----QHRFDILDQEMKTLMTQIDGVN 908
Query: 573 NEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLR 632
+ +V++ H Y +N +W + LV R +A+ + A + HN
Sbjct: 909 LAANSLVESGHPRSREVKQYQ----DHLNTRWQAFQTLVSERREAV--DSALRVHN---- 958
Query: 633 KQFGAQANVIGPWIQTK---MEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLE 689
+ WI K +E + ++ G + Q L E+ + + ++D LE
Sbjct: 959 --YCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRK-LSGLERDVAAIQARVDALE 1015
Query: 690 GDHQLIQEALIFDNKHTNYTMEHIRVGWEQL 720
+ Q + ++ + +H+ W+ L
Sbjct: 1016 RESQQLMDSHPEQKEDIGQRQKHLEELWQGL 1046
Score = 48.5 bits (114), Expect = 3e-05
Identities = 58/272 (21%), Positives = 105/272 (38%), Gaps = 45/272 (16%)
Query: 268 VNQENEQLMED---YEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHK 324
++ E +QLM++ + L S LE + R L+ E T H + D R
Sbjct: 1332 IDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLR------- 1384
Query: 325 PPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLE-----------Q 373
+Q L + ++ +LR + + S RM++ + + Q
Sbjct: 1385 ---LQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQ 1441
Query: 374 V----EKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEA------------WTDGKEAML 417
V E+G + L E R L+ L+ L + +Q S W + + +
Sbjct: 1442 VPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLA 1501
Query: 418 RQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQ 477
+ DY T L ++ +KK++ ++++ H RVE + Q+L E D + R
Sbjct: 1502 QSADYGT-NLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLG 1560
Query: 478 KICDQWDNL----GALTQKRREALERTEKLLE 505
+ WD L Q+ R+A E + L+
Sbjct: 1561 HLQSSWDRLREAAAGRLQRLRDANEAQQYYLD 1592
Score = 48.1 bits (113), Expect = 4e-05
Identities = 66/269 (24%), Positives = 107/269 (39%), Gaps = 36/269 (13%)
Query: 248 AFSGAQKAETAANRICKVLAVNQ--------ENEQLMEDYEK-----LASDLLEWIRRTI 294
A++G +KAE N+ +V A Q QL++ +K +A DLL W+ I
Sbjct: 1865 AYAG-EKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESII 1923
Query: 295 PWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFM 354
+E + E RD + K + EI + L + +
Sbjct: 1924 RQIETQ-------------ERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLL 1970
Query: 355 PSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAE--KFRQKASIHEAWTDG 412
+ + +I L+QV +E R ERL L E +F + AS+ EAW
Sbjct: 1971 QRQHQASEEIREK---LQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIA 2027
Query: 413 KEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQI-AAIAQELNELDYYDSPS 471
+E L D+ T+ ++ L+K+HEAFE A+ +R + EL E + P+
Sbjct: 2028 QEPYLASGDFGH-TVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELKERQIAERPA 2086
Query: 472 VNARCQKICDQWDNLGALTQKRREALERT 500
Q+ ++ + G A ERT
Sbjct: 2087 EETGPQE--EEGETAGEAPVSHHAATERT 2113
Score = 38.5 bits (88), Expect = 0.028
Identities = 35/135 (25%), Positives = 59/135 (43%), Gaps = 11/135 (8%)
Query: 397 EKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAA 456
+ F Q W + K + Y+ A K L KH+AF ++LA+H+ +E I A
Sbjct: 1277 QNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWL--KHQAFVAELASHEGWLENIDA 1334
Query: 457 IAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAK 516
++L + + V+ + + + WD L A T+++ + L L L+
Sbjct: 1335 EGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARS-----SDLRLQ--- 1386
Query: 517 RAAPFNNWMEGAMED 531
A N W+ AMED
Sbjct: 1387 THADLNKWI-SAMED 1400
Score = 37.4 bits (85), Expect = 0.063
Identities = 59/311 (18%), Positives = 120/311 (38%), Gaps = 50/311 (16%)
Query: 409 WTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYD 468
W K ++ L+ I A+ +K E D+AA Q RV+ + +Q+L +
Sbjct: 969 WITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQ 1028
Query: 469 SPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGA 528
+ R + + + W L +++L+ E LL + QL +
Sbjct: 1029 KEDIGQRQKHLEELWQGL-------QQSLQGQEDLLGEVSQL---------------QAF 1066
Query: 529 MEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYH----- 583
++DL D I A E +LP+A++ GI +E+ +Y
Sbjct: 1067 LQDLDD---FQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKES 1123
Query: 584 ---VNMAGTNPYTTITPQEING---KWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGA 637
V T+P + Q + G W+ + ++ R L + Q+ + ++
Sbjct: 1124 GEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAI 1183
Query: 638 QANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEK---SIVNYKPKI-DQLEGDHQ 693
+N +E +E +LE + +R++E S+ N + K+ ++ ++
Sbjct: 1184 LSN----------QEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNK 1233
Query: 694 LIQEALIFDNK 704
L+ E ++ +K
Sbjct: 1234 LVAEGNLYSDK 1244
Score = 36.2 bits (82), Expect = 0.14
Identities = 33/173 (19%), Positives = 74/173 (42%), Gaps = 16/173 (9%)
Query: 387 RRLERLDHLAEKFRQKASIHE--AWTDGKEAMLRQKDYETAT--LSEIKALLKKHEAFES 442
RR + +D A+KFR + + +W E+++RQ + + +S ++ L+K H+ +
Sbjct: 1895 RRTQLVD-TADKFRFFSMARDLLSWM---ESIIRQIETQERPRDVSSVELLMKYHQGINA 1950
Query: 443 DLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEK 502
++ + + L + + S + + Q++ + + +K ER
Sbjct: 1951 EIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMN---EKWEARWERLRM 2007
Query: 503 LLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFK 555
LLE ++++ A+ W+ L HT++ ++ L HE F+
Sbjct: 2008 LLEVC-----QFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFE 2055
>gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens]
Length = 2390
Score = 427 bits (1098), Expect = e-119
Identities = 236/572 (41%), Positives = 343/572 (59%), Gaps = 30/572 (5%)
Query: 6 SQQTNDYMQPEEDWDRDLLLDPAWEKQ------------QRKTFTAWCNSHLRKAGTQIE 53
S N + P+ DWD D +E+ Q+KTFT W NSHL + ++
Sbjct: 20 SDINNRWDLPDSDWDNDSSSARLFERSRIKALADEREAVQKKTFTKWVNSHLARVTCRVG 79
Query: 54 NIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAE 113
++ D RDG L+ LLEV+SGE L KP +G+MR+H + NV+KAL F+ + V L ++G+
Sbjct: 80 DLYSDLRDGRNLLRLLEVLSGEILPKPTKGRMRIHCLENVDKALQFLKEQKVHLENMGSH 139
Query: 114 EIVDGNVKMTLGMIWTIILRFAIQDISVE------ETSAKEGLLLWCQRKTAPYKNVNIQ 167
+IVDGN ++TLG++WTIILRF IQDISVE + SAK+ LLLWCQ KTA Y NVN+
Sbjct: 140 DIVDGNHRLTLGLVWTIILRFQIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNVH 199
Query: 168 NFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDI 227
NF SW+DGL F A++H+HRP+L+D+ L+K + NL AF++AEK L + K+LD ED
Sbjct: 200 NFTTSWRDGLAFNAIVHKHRPDLLDFESLKKCNAHYNLQNAFNLAEKELGLTKLLDPED- 258
Query: 228 VGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLL 287
V +PDEK+I+TYV+++YH FS + RI KVL E E+L+E YE LAS+LL
Sbjct: 259 VNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDHAMEAERLVEKYESLASELL 318
Query: 288 EWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRL 347
+WI +TI L +R N++ +Q +L+ F YR + KPPK EK LE+ T+Q+KLR
Sbjct: 319 QWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRA 378
Query: 348 SNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHE 407
+N+ + P EGR++SDIN AW LE+ E E L E+ R E+L+ LA +F +KA++ E
Sbjct: 379 NNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRE 438
Query: 408 AWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYY 467
W + ++ Q ++ L+ ++A ++KHEA E+D+ A+ RV+ + A+A EL Y+
Sbjct: 439 TWLSENQRLVSQDNF-GLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYH 497
Query: 468 DSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETI-DQLYLEYAKRAAPFNNWME 526
D + AR + WD L + RRE L +L + D LYL +WME
Sbjct: 498 DIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYL---------MDWME 548
Query: 527 GAMEDLQDTFIVHTIEEIQGLTTAHEQFKATL 558
LQ + + ++ L HE +A +
Sbjct: 549 EMKGRLQSQDLGRHLAGVEDLLQLHELVEADI 580
Score = 56.2 bits (134), Expect = 1e-07
Identities = 96/465 (20%), Positives = 180/465 (38%), Gaps = 60/465 (12%)
Query: 263 CKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRL 322
C+ L ++E Q D E I W+ R+P M +E +D +
Sbjct: 1481 CRRLQASREQHQFHRDVED-----------EILWVTERLP------MASSMEHGKDLPSV 1523
Query: 323 HKPPKVQEKCQLEINFNTLQ-TKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEW 381
K + Q EI + + LR R + G ++++ W L G+E
Sbjct: 1524 QLLMKKNQTLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKRL-----GHELE 1578
Query: 382 LLNEIRRLERLDHL-AEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAF 440
L +RLE D L A++F + A+ EAW +E + ++ LS +A +KKH+
Sbjct: 1579 LRG--KRLE--DALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSA-QAEVKKHQVL 1633
Query: 441 ESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERT 500
E LA + + Q+AA +Q++ + ++ +S ++ R ++ + L L +RRE L+
Sbjct: 1634 EQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEH 1693
Query: 501 EKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPD 560
+L + +L W++ + E + L +F
Sbjct: 1694 LRLCQLRREL--------DDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTST 1745
Query: 561 ADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTE 620
+ER+ + + ++ H A + +N W + +L+ R Q L
Sbjct: 1746 IGQERVD--SANALANGLIAGGHAARATVAEWK----DSLNEAWADLLELLDTRGQVLAA 1799
Query: 621 EHARQQHNERLRKQFGAQANVIGPWIQTKMEEI----GRISIEMHGTLEDQLSHLRQYEK 676
+ Q+ R+ +Q K +++ GR +++ Q H YE
Sbjct: 1800 AYELQRFLHGARQALAR--------VQHKQQQLPDGTGR---DLNAAEALQRRHCA-YEH 1847
Query: 677 SIVNYKPKIDQLEGDHQLIQEALIFDN-KHTNYTMEHIRVGWEQL 720
I P++ Q++ D +Q+A D + M+ + W QL
Sbjct: 1848 DIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQL 1892
Score = 48.9 bits (115), Expect = 2e-05
Identities = 80/426 (18%), Positives = 158/426 (37%), Gaps = 61/426 (14%)
Query: 296 WLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQ-LEINFNTLQTKLRLSNRPAFM 354
W+E + A+ ++LED VQ++ + LE NTL ++ N A
Sbjct: 867 WVEEKEQWLNGLALPERLEDLE---------VVQQRFETLEPEMNTLAAQITAVNDIAEQ 917
Query: 355 ------PSEGRMVS---DINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASI 405
P + R+V+ +N+ W ++ G + L + + + + + +
Sbjct: 918 LLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALS--------IQNYHLECTE 969
Query: 406 HEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELD 465
+AW K ++ L+ + AL +K E DL A RV ++ A L
Sbjct: 970 TQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGH 1029
Query: 466 YYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWM 525
+ ++NAR +++ W++L A ++R E+L +L ++ + F W+
Sbjct: 1030 PAQAVAINARLREVQTGWEDLRATMRRREESLGEARRL--------QDFLRSLDDFQAWL 1081
Query: 526 EGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVN 585
+ T+ E + L H + + A E + + EV++
Sbjct: 1082 GRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTR-------- 1133
Query: 586 MAGTNPYTTITPQEING---KWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVI 642
+P Q + W+ + ++ R L + H Q R+ G ++
Sbjct: 1134 -DQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSS-- 1190
Query: 643 GPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQ----LEGDHQLIQEA 698
+E EM GTL+ + +++ E + ++ LE QL+ E
Sbjct: 1191 --------QEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEG 1242
Query: 699 LIFDNK 704
I +K
Sbjct: 1243 NIHADK 1248
Score = 47.4 bits (111), Expect = 6e-05
Identities = 82/436 (18%), Positives = 158/436 (36%), Gaps = 60/436 (13%)
Query: 264 KVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLH 323
+++A +E L + +K+ DLL + W+E + + L D +LH
Sbjct: 518 QMVAARRERLLLNLELQKVFQDLLY----LMDWMEEMKGRLQSQDLGRHLAGVEDLLQLH 573
Query: 324 KPPKVQEKCQLEINFNTLQTKLRLSNR-PAFMPSEGRMVSDINNAWGCLEQVEKGYEEWL 382
+ + Q E + LR N + P + ++VS+ + ++E+ YE
Sbjct: 574 ELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSER------VAKLEQSYEALC 627
Query: 383 LNEIRRLERLDHLAE--KFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAF 440
R RL+ +F + EAW ++ +L D ++ LL KH A
Sbjct: 628 ELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALR-LLNKHTAL 686
Query: 441 ESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERT 500
+++ ++ Q+L + + +AR ++ QW+ L AL ++R + L +
Sbjct: 687 RGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQA 746
Query: 501 EKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAH----EQFKA 556
L ++ A W+ A+ + + H Q L H E+ ++
Sbjct: 747 ASL--------YQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRS 798
Query: 557 TLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWD----HVRQLVP 612
P D R A P T E+ G+ H +L
Sbjct: 799 HRPTLDALR-------------------EQAAALPPTLSRTPEVQGRVPTLERHYEEL-- 837
Query: 613 RRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLR 672
QA E AR ++A G W++ K + + ++ L ++L L
Sbjct: 838 ---QARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLA------LPERLEDLE 888
Query: 673 QYEKSIVNYKPKIDQL 688
++ +P+++ L
Sbjct: 889 VVQQRFETLEPEMNTL 904
Score = 45.1 bits (105), Expect = 3e-04
Identities = 95/442 (21%), Positives = 162/442 (36%), Gaps = 61/442 (13%)
Query: 350 RPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAW 409
+P + D++ W LE + L + R AE F Q E+W
Sbjct: 1347 KPELKALVSEKLRDLHRRWDELETTTQAKARSLFDANR--------AELFAQSCCALESW 1398
Query: 410 TDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDS 469
+ +A L DY L+ + LLKK + E ++A + VE I A A+ L + D
Sbjct: 1399 LESLQAQLHSDDY-GKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQED--QG 1455
Query: 470 PSVNARCQKICDQWDNLGALTQKRREALERTEKLLE------TIDQLYLEYAKRAAPFNN 523
R + + + AL Q RE R + E ++ L +R P +
Sbjct: 1456 AGEVERTSRAVE--EKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTER-LPMAS 1512
Query: 524 WMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYH 583
ME + ++ + +Q HE A L +ER LG ++ +
Sbjct: 1513 SMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADL----RERQRALGAAAAGPELAELQE 1568
Query: 584 V-NMAGTNPYTTITPQEINGK--WDHVRQLVPRRDQA-----LTEEHARQQHNERLRKQF 635
+ G E+ GK D +R RD A + E+ E+ + +
Sbjct: 1569 MWKRLGHE-------LELRGKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDEL 1621
Query: 636 GAQANVIGPWI-QTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQL-EGDHQ 693
AQA V + + + + + ++ + +D + H I + ++D+L G +
Sbjct: 1622 SAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKE 1681
Query: 694 LIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEF-- 751
L E EH+R L + R ++++E I R+ S E ++
Sbjct: 1682 LAGE-------RRERLQEHLR------LCQLRRELDDLEQWIQEREVVAASHELGQDYEH 1728
Query: 752 ----RASFNHFDRDHSGTLGPE 769
R F F RD S T+G E
Sbjct: 1729 VTMLRDKFREFSRDTS-TIGQE 1749
Score = 39.3 bits (90), Expect = 0.016
Identities = 20/68 (29%), Positives = 40/68 (58%), Gaps = 4/68 (5%)
Query: 399 FRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDR---VEQIA 455
F + A + EAW +E ++R + T+ E+++L+K+HEAF+ A ++R +E++
Sbjct: 2018 FGRDAGMAEAWLCSQEPLVRSAELG-CTVDEVESLIKRHEAFQKSAVAWEERFCALEKLT 2076
Query: 456 AIAQELNE 463
A+ + E
Sbjct: 2077 ALEEREKE 2084
Score = 37.7 bits (86), Expect = 0.048
Identities = 35/143 (24%), Positives = 65/143 (45%), Gaps = 4/143 (2%)
Query: 356 SEGRMVSD-INNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKE 414
SEG + +D I +E+ K ++ + RL R + + F Q + W D E
Sbjct: 1240 SEGNIHADKIREKADSIERRHKKNQDAAQQFLGRL-RDNREQQHFLQDCHELKLWID--E 1296
Query: 415 AMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNA 474
ML +D + +KH+AF ++LAA++D ++++ +EL V+
Sbjct: 1297 KMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSE 1356
Query: 475 RCQKICDQWDNLGALTQKRREAL 497
+ + + +WD L TQ + +L
Sbjct: 1357 KLRDLHRRWDELETTTQAKARSL 1379
Score = 35.0 bits (79), Expect = 0.31
Identities = 41/228 (17%), Positives = 85/228 (37%), Gaps = 20/228 (8%)
Query: 508 DQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPD---ADKE 564
++L +Y A+ W+E + L D + +++ +Q + ++ +K
Sbjct: 304 ERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKG 363
Query: 565 RLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQE------INGKWDHVRQLVPRRDQAL 618
L +L + SK+ N TP+E IN W+ + + R+ AL
Sbjct: 364 NLEVL-LFTIQSKL---------RANNQKVYTPREGRLISDINKAWERLEKAEHERELAL 413
Query: 619 TEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMH-GTLEDQLSHLRQYEKS 677
E RQ+ E+L +F +A + W+ + + + + +E + E
Sbjct: 414 RTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETD 473
Query: 678 IVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIA 725
IV Y ++ ++ + D K ++ W+ L +A
Sbjct: 474 IVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVA 521
Score = 31.6 bits (70), Expect = 3.4
Identities = 20/78 (25%), Positives = 39/78 (50%), Gaps = 2/78 (2%)
Query: 427 LSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYD-SPSVNARCQKICDQWDN 485
L+ +AL ++H A+E D+ A +V+Q+ L + D + + Q + + W
Sbjct: 1832 LNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQ 1891
Query: 486 L-GALTQKRREALERTEK 502
L G+ +R+ L+ T+K
Sbjct: 1892 LQGSSAARRQLLLDTTDK 1909
>gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1
[Homo sapiens]
Length = 2564
Score = 405 bits (1042), Expect = e-113
Identities = 221/487 (45%), Positives = 310/487 (63%), Gaps = 8/487 (1%)
Query: 30 EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHK 89
E Q+KTFT W NSHL + G I ++ D RDG L LLEV+SGE+L +P RG+MR+H
Sbjct: 60 EAVQKKTFTKWVNSHLARVGCHIGDLYVDLRDGFVLTRLLEVLSGEQLPRPTRGRMRIHS 119
Query: 90 ISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVE-----ET 144
+ NV+KAL F+ + V L ++G+ +IVDGN ++TLG++WTIILRF IQ I +E ET
Sbjct: 120 LENVDKALQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWTIILRFQIQVIKIETEDNRET 179
Query: 145 -SAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLT 203
SAK+ LLLWCQ KTA Y VNIQNF SW+DGL F ALIHRHRP+L+D+ KL K +
Sbjct: 180 RSAKDALLLWCQMKTAGYPEVNIQNFTTSWRDGLAFNALIHRHRPDLVDFSKLTKSNANY 239
Query: 204 NLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRIC 263
NL AF AE++L + ++LD ED V PDEK+I+TYV SFYH FS + RI
Sbjct: 240 NLQRAFRTAEQHLGLARLLDPED-VNMEAPDEKSIITYVVSFYHYFSKMKALAVEGKRIG 298
Query: 264 KVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLH 323
KVL E +++E YE+LA++LL WI RT+ + N+ N++ +QQ+L+ F Y L
Sbjct: 299 KVLDQVLEVGKIIERYEELAAELLAWIHRTVGLISNQKFANSLSGVQQQLQAFTAYCTLE 358
Query: 324 KPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLL 383
KP K QEK LE+ ++Q+KLR NR F+P EG + DI+ AWG LE+ E E L
Sbjct: 359 KPVKFQEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHEREAALR 418
Query: 384 NEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESD 443
E+ R E+L+ LA++F K ++ E+W + + ++ Q ++ L ++A +KKHEA E+D
Sbjct: 419 AELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNF-GYELPAVEAAMKKHEAIEAD 477
Query: 444 LAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKL 503
+AA+++RV+ +A +AQ L YYD V A+ + QW L L RR LE+ L
Sbjct: 478 IAAYEERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQWALLTGLVGARRTRLEQNLAL 537
Query: 504 LETIDQL 510
+ ++
Sbjct: 538 QKVFQEM 544
Score = 64.3 bits (155), Expect = 5e-10
Identities = 96/486 (19%), Positives = 202/486 (41%), Gaps = 60/486 (12%)
Query: 253 QKAETAANRICKVLAVNQENEQLM---EDYEKLASDL---LEWIRRTIPWLENRVPENTM 306
++ R+ ++L QE +L+ ++ ++A DL L W++ +P N +
Sbjct: 1488 ERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGL 1547
Query: 307 HAMQQKLEDFRDYRRLHKP--PKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDI 364
A+QQ ++ + RR + P+++E + +L++ + R R + +
Sbjct: 1548 QAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVR--------RGLEQL 1599
Query: 365 NNAWGCLEQVEKGYEEWLLNEIRRLERLDHL--AEKFRQKASIHEAWTDGKEAMLRQKDY 422
+AW L + + RR + LD E++ + EAW +E ++ +D
Sbjct: 1600 QSAWAGLREAAE----------RRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDK 1649
Query: 423 ETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQ 482
S ++ LLKKH E + +++ + Q++ + L E+ + DS ++ R ++
Sbjct: 1650 GKDEQSTLQ-LLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRL 1708
Query: 483 WDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIE 542
+ L L ++RR ALE+ L + +++ + +W+ + E
Sbjct: 1709 YVALKELGEERRVALEQQYWL--------YQLSRQVSELEHWIAEKEVVAGSPELGQDFE 1760
Query: 543 EIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEING 602
+ L +F + A +ERLA ++ V ++++ H A + +N
Sbjct: 1761 HVSVLQEKFSEFASETGMAGRERLA--AVNQMVDELIECGHTAAATMAEW----KDGLNE 1814
Query: 603 KWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISI--EM 660
W + +L+ R Q L +R+ H +F + A + I+ K + R++ E
Sbjct: 1815 AWAELLELMGTRAQLLAA--SRELH------KFFSDARELQGQIEEKRRRLPRLTTPPEP 1866
Query: 661 HGTLEDQLSHLRQYEKSIVNYKPKIDQL-EGDHQLIQEALIFDNKHTNYTM---EHIRVG 716
+ LR +E + ++ QL EG QL ++ +H + + G
Sbjct: 1867 RPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQL---RTVYAGEHAEAIASREQEVLQG 1923
Query: 717 WEQLLT 722
W++LL+
Sbjct: 1924 WKELLS 1929
Score = 43.5 bits (101), Expect = 9e-04
Identities = 69/318 (21%), Positives = 135/318 (42%), Gaps = 32/318 (10%)
Query: 264 KVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLH 323
++LA ++E + D +L + E RR P + +MQ+ L F +L
Sbjct: 1828 QLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQL- 1886
Query: 324 KPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLL 383
V + QL+ L+T + A E ++V +G++E L
Sbjct: 1887 ---LVSQVRQLQEGAAQLRTVYAGEHAEAIASRE--------------QEVLQGWKELLS 1929
Query: 384 N-EIRRLERLDHLAEKFRQKASIHE--AWTDGKEAMLRQKDYETATLSEIKALLKKHEAF 440
E RL + A+ R + + + +W DG + + D + +S ++ L+ H+
Sbjct: 1930 ACEDARLH-VSSTADALRFHSQVRDLLSWMDGIASQIGAAD-KPRDVSSVEVLMNYHQGL 1987
Query: 441 ESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERT 500
+++L A RV ++ QEL + +A +I Q D LG ++ E +R
Sbjct: 1988 KTELEA---RVPELTT-CQELGRSLLLNK---SAMADEIQAQLDKLGTRKEEVSEKWDRH 2040
Query: 501 EKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPD 560
+ L+ + +++ ++A+ A + W+ LQ + +++E++ L HE F+
Sbjct: 2041 WEWLQQMLEVH-QFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRKAAA- 2098
Query: 561 ADKERLAILGIHNEVSKI 578
A +ER + L + KI
Sbjct: 2099 AWEERFSSLRRLTTIEKI 2116
Score = 40.0 bits (92), Expect = 0.010
Identities = 34/126 (26%), Positives = 57/126 (45%), Gaps = 5/126 (3%)
Query: 388 RLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAH 447
RLE+ L + F++ + + W + +A L ++ L E LL+KH E D+AA
Sbjct: 530 RLEQNLALQKVFQEMVYMVD-WMEEMQAQLLSRECGQH-LVEADDLLQKHGLLEGDIAAQ 587
Query: 448 QDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQ---KRREALERTEKLL 504
+RVE + A A ++L Y C ++ L L + +RR LE + L
Sbjct: 588 SERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAELQEQAARRRAELEASRSLW 647
Query: 505 ETIDQL 510
+ +L
Sbjct: 648 ALLQEL 653
Score = 32.7 bits (73), Expect = 1.5
Identities = 26/103 (25%), Positives = 47/103 (45%), Gaps = 4/103 (3%)
Query: 414 EAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVN 473
E ML +D ++ +H+AF ++LA +++ +E+I Q+L + + SV
Sbjct: 1323 EKMLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVR 1382
Query: 474 ARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAK 516
+ +I W L + TQ + L K DQL +A+
Sbjct: 1383 KKLGEIRQCWAELESTTQAKARQLFEASK----ADQLVQSFAE 1421
Score = 32.0 bits (71), Expect = 2.6
Identities = 43/199 (21%), Positives = 77/199 (38%), Gaps = 18/199 (9%)
Query: 363 DINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDY 422
++ WG L + E + RL+R H + F + G E L
Sbjct: 1065 ELGAEWGALASAAQACGE-AVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPN--- 1120
Query: 423 ETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYD---SPSVNARCQKI 479
+L E ALL +H A + ++ ++ +I A ++ L D + +++ +
Sbjct: 1121 ---SLEEADALLARHAALKEEVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPHL 1177
Query: 480 CDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVH 539
W L L + RREAL + I QL+L ++A E A+ + +
Sbjct: 1178 ELGWHKLLGLWEARREALVQAH-----IYQLFLRDLRQALVVLRNQEMALSGAE---LPG 1229
Query: 540 TIEEIQGLTTAHEQFKATL 558
T+E ++ H F T+
Sbjct: 1230 TVESVEEALKQHRDFLTTM 1248
Score = 31.2 bits (69), Expect = 4.5
Identities = 26/114 (22%), Positives = 51/114 (44%), Gaps = 4/114 (3%)
Query: 386 IRRLERLDHLAEKFRQKASIH--EAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESD 443
+RR D LA +R +H E W KE L + L +++ + + E+ + +
Sbjct: 872 LRRQWLRDALAV-YRMFGEVHACELWIGEKEQWLLSMRVPDS-LDDVEVVQHRFESLDQE 929
Query: 444 LAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREAL 497
+ + RV + QEL E + S V + + +W+ + L ++R+E +
Sbjct: 930 MNSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEM 983
>gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens]
Length = 3639
Score = 344 bits (882), Expect = 2e-94
Identities = 204/537 (37%), Positives = 307/537 (57%), Gaps = 21/537 (3%)
Query: 31 KQQRKTFTAWCNSHLR--KAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVH 88
+ Q KTFT W N+ + +AG +I N+ + DG+ L+ LLE+ISGE L P RG++RVH
Sbjct: 19 QMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISGEALPPPSRGRLRVH 78
Query: 89 KISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEET---- 144
+ N ++AL F+ +K V + IG E IVDG+ + LG+IW IILRF I IS+++
Sbjct: 79 FLENSSRALAFLRAK-VPVPLIGPENIVDGDQTLILGLIWVIILRFQISHISLDKEEFGA 137
Query: 145 -----SAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKD 199
S KE LL+WCQRKTA Y NVNI +F SW DGLGF ALIH HRP+L+DYG LR D
Sbjct: 138 SAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHAHRPDLLDYGSLRPD 197
Query: 200 DPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAA 259
PL NL AF VAE+ L I ++LD ED V A+PDE++IMTYVS +YH S + +T
Sbjct: 198 RPLHNLAFAFLVAEQELGIAQLLDPED-VAAAQPDERSIMTYVSLYYHYCSRLHQGQTVQ 256
Query: 260 NRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDY 319
R+ K+L QE E L YE+L +DLL WI LE R +++ AM+Q L F +
Sbjct: 257 RRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIF 316
Query: 320 RRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYE 379
R KPP++Q++ E LQT L+ NR F+P EG +++++ W LE E
Sbjct: 317 RTQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCWAGLEWAEAARS 376
Query: 380 EWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEA 439
+ L + +L+RL+ LA +F+ KA++ E++ E +L Q A+L+ ++A +++
Sbjct: 377 QALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGM 436
Query: 440 FESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALER 499
E+ + + R + +A IA L + Y+ V R +++ +W L Q +R+ +
Sbjct: 437 LEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVAD 496
Query: 500 TEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKA 556
+ +L + ++ AA ++ +E E + T + E+ L H+ +A
Sbjct: 497 MQAVLSLLQEV------EAA--SHQLEELQEPARSTACGQQLAEVVELLQRHDLLEA 545
Score = 54.3 bits (129), Expect = 5e-07
Identities = 59/246 (23%), Positives = 109/246 (44%), Gaps = 39/246 (15%)
Query: 285 DLLEWIRRTI---PWLENRVPENTMHAMQQKLED-------FRDYRRLHKPPKVQEKCQL 334
+ LE+++R W++ + + + + Q LE R++R V + C
Sbjct: 2221 NFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIR 2280
Query: 335 EINFNTLQTKLRLSNRPAFMPSEGRMV----SDINNAWGCLEQVEKGYEEWLLN--EIRR 388
I+ +LQ K R P E +++ S +NN W Y++ L EI
Sbjct: 2281 SISDLSLQLKNR-------DPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHV 2333
Query: 389 LER-LDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAH 447
L R LD++ ++ ++K ++ +A GK+ L ++ LL+KHE E ++
Sbjct: 2334 LSRELDNVTKRIQEKEALIQALDCGKD------------LESVQRLLRKHEELEREVHPI 2381
Query: 448 QDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALE---RTEKLL 504
Q +VE + L + + + R Q++ + W L + QKRREAL+ + +KL
Sbjct: 2382 QAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQ 2441
Query: 505 ETIDQL 510
+ +L
Sbjct: 2442 AMLQEL 2447
Score = 47.4 bits (111), Expect = 6e-05
Identities = 49/230 (21%), Positives = 92/230 (40%), Gaps = 10/230 (4%)
Query: 329 QEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRR 388
Q + + ++ Q + L AF+ + D+ L Q K E L
Sbjct: 2794 QRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTA 2853
Query: 389 LERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQ 448
LE L + FR A AW K + +DY + LS ++ L ++H+ ES++++H+
Sbjct: 2854 LEARSLLLKFFRD-ADEEMAWVQEKLPLAAAQDYGQS-LSAVRHLQEQHQNLESEMSSHE 2911
Query: 449 DRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETID 508
+ +L + ++ + V AR Q++ +L A +RR L++ ++ + +
Sbjct: 2912 ALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLT 2971
Query: 509 QLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATL 558
+L +W+ L + H+ E Q L E K L
Sbjct: 2972 EL--------LEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDL 3013
Score = 45.4 bits (106), Expect = 2e-04
Identities = 57/253 (22%), Positives = 107/253 (42%), Gaps = 24/253 (9%)
Query: 334 LEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLD 393
LE + LQ+ + P + S+ + + G L+QV+ E + RR +
Sbjct: 1013 LERRVHFLQSVVVKVEEPGYAESQP-LQGQVETLQGLLKQVQ----EQVAQRARR-QAET 1066
Query: 394 HLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQ 453
+ F Q++ W + +A LR K+ + ++ + LL++H+ ++ Q+R++Q
Sbjct: 1067 QARQSFLQESQQLLLWAESVQAQLRSKEV-SVDVASAQRLLREHQDLLEEIHLWQERLQQ 1125
Query: 454 IAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALE---RTEKLLETIDQL 510
+ A +Q + LD DS V + + Q L L ++R++ L+ +K +D
Sbjct: 1126 LDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGF 1185
Query: 511 YLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILG 570
A A W+ +++L + + E L H +F L R L
Sbjct: 1186 TATCANHQA----WLH--LDNLGE-----DVREALSLLQQHREFGRLLSTLG-PRAEALR 1233
Query: 571 IHNEVSKIVQTYH 583
H E K+VQ+ H
Sbjct: 1234 AHGE--KLVQSQH 1244
Score = 43.5 bits (101), Expect = 9e-04
Identities = 31/121 (25%), Positives = 55/121 (45%), Gaps = 1/121 (0%)
Query: 395 LAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQI 454
L F Q A+ E W L++ ++K LLK H+AFE+++ AH++ + +
Sbjct: 2115 LMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLK-HQAFEAEVQAHEEVMTSV 2173
Query: 455 AAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEY 514
A + L + + V+ R Q + W++L R + LE LE + ++ L
Sbjct: 2174 AKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAE 2233
Query: 515 A 515
A
Sbjct: 2234 A 2234
Score = 42.0 bits (97), Expect = 0.003
Identities = 41/175 (23%), Positives = 73/175 (41%), Gaps = 4/175 (2%)
Query: 330 EKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYE-EWLLNEIRR 388
++C+ E++ T L S + + SDI LEQ E W ++++
Sbjct: 2478 QECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQL 2537
Query: 389 LERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQ 448
+ L+ + F E W KE L + L+ ++ LL KH+ E DL
Sbjct: 2538 QQALE--LQLFLSSVEKMERWLCSKEDSLASEGLWDP-LAPMEPLLWKHKMLEWDLEVQA 2594
Query: 449 DRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKL 503
++ + A A+ L++ + ++ S RCQ + + + L RR LE +L
Sbjct: 2595 GKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQL 2649
Score = 41.6 bits (96), Expect = 0.003
Identities = 79/380 (20%), Positives = 139/380 (36%), Gaps = 37/380 (9%)
Query: 252 AQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIR---RTIPWLENRVPENTMHA 308
AQ E A R+ + +E Q + S LL++ R + W++ ++P
Sbjct: 2826 AQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQD 2885
Query: 309 MQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAW 368
Q L R + H+ + + + L T +L F E
Sbjct: 2886 YGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHE---------VA 2936
Query: 369 GCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEA--WTDGKEAMLRQKDYETAT 426
++Q+EK RR L E + + EA W + +L +D +
Sbjct: 2937 ARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSA 2996
Query: 427 LSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNL 486
+ALL++ EA + DL A R+E++ A L +SP V A+ Q + +
Sbjct: 2997 -EATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVRE----- 3050
Query: 487 GALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWM--EGAMEDLQDTFIVHTIEEI 544
A + R A R L E + LE + + W+ + A + QD +++
Sbjct: 3051 -AHAELLRRAEARGHGLQEQLQLHQLE--RETLLLDAWLTTKAATAESQDYG-----QDL 3102
Query: 545 QGLTTAHEQFKATLPDADKERLAILGIHN--EVSKIVQTYHVNMAGTNPYTTITPQEING 602
+G+ E+F DA ++ + LG + K+ T P+ I
Sbjct: 3103 EGVKVLEEKF-----DAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEA 3157
Query: 603 KWDHVRQLVPRRDQALTEEH 622
W+ + Q + R + L H
Sbjct: 3158 AWERLDQAIKARTENLAAAH 3177
Score = 40.8 bits (94), Expect = 0.006
Identities = 44/190 (23%), Positives = 81/190 (42%), Gaps = 15/190 (7%)
Query: 372 EQVEKGYEEWLL----NEIRRLERLDHLA-EKFRQKASIHEAWTDGKEAMLRQKDYETAT 426
EQ++ +W +E RR + L L ++++Q + W + K M + +
Sbjct: 1252 EQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEP--SGA 1309
Query: 427 LSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNL 486
I LK+HEA ES+L A + VE + + +EL + R Q + +W+ L
Sbjct: 1310 RRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEAL 1369
Query: 487 GALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQG 546
+R + L++ + + + QL + A +EGA LQ + + Q
Sbjct: 1370 NRKMTERGDELQQAGQQEQLLRQL-----QDAKEQLEQLEGA---LQSSETGQDLRSSQR 1421
Query: 547 LTTAHEQFKA 556
L H+Q ++
Sbjct: 1422 LQKRHQQLES 1431
Score = 39.3 bits (90), Expect = 0.016
Identities = 29/130 (22%), Positives = 58/130 (44%), Gaps = 8/130 (6%)
Query: 427 LSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNL 486
L+E+ LL++H+ E+ ++AH V +A EL+ + A+ + + +L
Sbjct: 530 LAEVVELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSL 589
Query: 487 GALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQG 546
AL + RR LE+T + E + E A W++ + + + + + +I G
Sbjct: 590 VALVRARRALLEQTLQRAEFLRNCEEEEA--------WLKECGQRVGNAALGRDLSQIAG 641
Query: 547 LTTAHEQFKA 556
H+ +A
Sbjct: 642 ALQKHKALEA 651
Score = 38.5 bits (88), Expect = 0.028
Identities = 28/95 (29%), Positives = 47/95 (49%), Gaps = 7/95 (7%)
Query: 370 CLEQVEKGYEE----WLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETA 425
CL+++E +E W L R E +K RQ+ EAW E +L + DY +
Sbjct: 3359 CLQELEGRLQELEEAWALRWQRCAESWG--LQKLRQRLEQAEAWLACWEGLLLKPDYGHS 3416
Query: 426 TLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQE 460
+S+++ LL +H+ E LAA +++ Q+ E
Sbjct: 3417 -VSDVELLLHRHQDLEKLLAAQEEKFAQMQKTEME 3450
Score = 38.1 bits (87), Expect = 0.037
Identities = 41/182 (22%), Positives = 71/182 (39%), Gaps = 28/182 (15%)
Query: 379 EEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHE 438
++WL E L++ + F + H+AW D + E +LL++H
Sbjct: 1166 QQWL-QEGLELQKFGREVDGFTATCANHQAWL--------HLDNLGEDVREALSLLQQHR 1216
Query: 439 AFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALE 498
F L+ R E + A ++L + + + +V + Q I QW L +++RR L
Sbjct: 1217 EFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLL 1276
Query: 499 RTEKLLETIDQLYLEYAKRAAPFNNWME-----------GAMEDLQDTFIVHTIEEIQGL 547
+ +L E+ + A WME GA ++ T H E + L
Sbjct: 1277 ASLQL--------QEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELL 1328
Query: 548 TT 549
T
Sbjct: 1329 AT 1330
Score = 38.1 bits (87), Expect = 0.037
Identities = 48/226 (21%), Positives = 91/226 (40%), Gaps = 44/226 (19%)
Query: 314 EDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQ 373
+D R +RL K + QLE TL K M + M + + LE+
Sbjct: 1414 QDLRSSQRLQKRHQ-----QLESESRTLAAK---------MAALASMAHGMAASPAILEE 1459
Query: 374 VEKGYEEWLLNEIRRLERLD-HLA------------EKFRQKASIHEAWTDGKEAMLRQK 420
+K +RRLE L HLA +F +++ +W
Sbjct: 1460 TQK--------HLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPT 1511
Query: 421 DYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKIC 480
Y T L+ ++L +KH+ + ++ AHQ +V+++ + + L + + + +CQ++
Sbjct: 1512 SY-TECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELE 1570
Query: 481 DQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWME 526
W L + R + L++ T Q +L+ ++ W+E
Sbjct: 1571 GHWAELERACEARAQCLQQA----VTFQQYFLDVSE----LEGWVE 1608
Score = 37.0 bits (84), Expect = 0.082
Identities = 53/248 (21%), Positives = 91/248 (36%), Gaps = 24/248 (9%)
Query: 261 RICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYR 320
R C+ A + + Y S+L W+ P + +R ++ R
Sbjct: 1578 RACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSR---------DYGRDEAATLR 1628
Query: 321 RLHKPPKVQEKCQLEINFNTL----QTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEK 376
++K +QE +L I ++++ QT L+ +P + R+V + L + +
Sbjct: 1629 LINKHQALQE--ELAIYWSSMEELDQTAQTLTGPE--VPEQQRVVQER------LREQLR 1678
Query: 377 GYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKK 436
+E R LE L E R+ + + W ++ + + L K
Sbjct: 1679 ALQELAATRDRELEGTLRLHEFLREAEDL-QGWLASQKQAAKGGESLGEDPEHALHLCTK 1737
Query: 437 HEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREA 496
F+ + RV +A+ L E + P V R Q + W L LTQ R A
Sbjct: 1738 FAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHA 1797
Query: 497 LERTEKLL 504
L TE L
Sbjct: 1798 LRDTETTL 1805
Score = 34.3 bits (77), Expect = 0.53
Identities = 81/433 (18%), Positives = 165/433 (38%), Gaps = 60/433 (13%)
Query: 273 EQLMEDYEKLASDLLEWIR-RTIPWLENRVPENTMHAMQ-QKLEDFRDY--RRLHKPPKV 328
+ ++D +++A+ W+R + + LE + + M Q QK ++F+ +H+ ++
Sbjct: 2650 QAFLQDSQEVAA----WLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQEL 2705
Query: 329 QEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRR 388
Q + Q +L PA + R+ ++ WG L+ N ++
Sbjct: 2706 QREGQ----------RLLQGGHPASEAIQERL-EELGALWGELQD----------NSQKK 2744
Query: 389 LERLDHLAEKFRQKASIHEA--WTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAA 446
+ +L E R + S+ E W + E LR A L + LL E+ +
Sbjct: 2745 VAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQA-LPGVGELLGTQRELEAAVDK 2803
Query: 447 HQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLET 506
+ E + AQ + + V + +++ ++ +L Q+RR ALE LL+
Sbjct: 2804 KARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKF 2863
Query: 507 IDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERL 566
E A W++ + ++ ++ L H+ ++ + +
Sbjct: 2864 FRDADEEMA--------WVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTR 2915
Query: 567 AILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQ 626
+LG K+VQ H Q++ H+R RR L + Q
Sbjct: 2916 VVLGTG---YKLVQAGHF----AAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQ- 2967
Query: 627 HNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYE---KSIVNYKP 683
QF + G W+ + + S +M + E + LR+ E + + + P
Sbjct: 2968 -------QFLTELLEAGSWLAERGHVLD--SEDMGHSAEATQALLRRLEATKRDLEAFSP 3018
Query: 684 KIDQLEGDHQLIQ 696
+I++L+ L++
Sbjct: 3019 RIERLQQTAALLE 3031
Score = 33.9 bits (76), Expect = 0.69
Identities = 42/183 (22%), Positives = 69/183 (37%), Gaps = 23/183 (12%)
Query: 356 SEGRMV----SDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTD 411
S G MV D+ AW E W L + R L R + E T
Sbjct: 1768 SAGPMVRQRQQDLQTAWS---------ELWELTQARG-HALRDTETTLRVHRDLLEVLTQ 1817
Query: 412 GKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNEL-DYYDSP 470
+E + L ++A L+ H+ E +L + +++++ A + +L +
Sbjct: 1818 VQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAH 1877
Query: 471 SVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAME 530
+V R Q + W L ++RR LER +LL +YA +W +
Sbjct: 1878 AVQQRQQAVTQAWAVLQRRMEQRRAQLERA-RLLARFRTAVRDYA-------SWAARVRQ 1929
Query: 531 DLQ 533
DLQ
Sbjct: 1930 DLQ 1932
Score = 32.3 bits (72), Expect = 2.0
Identities = 38/181 (20%), Positives = 73/181 (40%), Gaps = 10/181 (5%)
Query: 388 RLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAH 447
+LER LA +FR + +W L Q + + S L H+ ++L A
Sbjct: 1903 QLERARLLA-RFRTAVRDYASWAARVRQDL-QVEESSQEPSSGPLKLSAHQWLRAELEAR 1960
Query: 448 QDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETI 507
+ +Q + Q+ + V + + DQ D + +++E L+ ++
Sbjct: 1961 EKLWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQ----- 2015
Query: 508 DQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLA 567
+QL+L R + L+ + + ++EE++ L HE F L DK+ A
Sbjct: 2016 EQLFLRECGRLEEI---LAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAA 2072
Query: 568 I 568
+
Sbjct: 2073 L 2073
Score = 30.0 bits (66), Expect = 10.0
Identities = 24/107 (22%), Positives = 41/107 (38%), Gaps = 8/107 (7%)
Query: 427 LSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNL 486
LS+I L+KH+A E+++ HQ + ++L+ P R + + W L
Sbjct: 636 LSQIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLL 695
Query: 487 GALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQ 533
R L+ L L+Y AA +W+ L+
Sbjct: 696 QTRVVGRGARLQTA--------LLVLQYFADAAEAASWLRERRSSLE 734
>gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
isoform 2 [Homo sapiens]
Length = 2472
Score = 288 bits (738), Expect = 1e-77
Identities = 167/501 (33%), Positives = 282/501 (56%), Gaps = 21/501 (4%)
Query: 398 KFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAA-HQDRVEQIAA 456
+F KA + E+W KE L+ DY LS ++ LL K E F++ L A Q+ + I A
Sbjct: 1980 QFNWKADVVESWIGEKENSLKTDDYGR-DLSSVQTLLTKQETFDAGLQAFQQEGIANITA 2038
Query: 457 IAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAK 516
+ +L + S ++ AR + +W L A + R++ L + ++ L+L +AK
Sbjct: 2039 LKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAK 2098
Query: 517 RAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDA--DKERLAILGIHNE 574
+A+ FN+W E A EDL D +++EEI+ L AH+ F+++L A D +LA E
Sbjct: 2099 KASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLA------E 2152
Query: 575 VSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQ 634
+ + ++++ V +NPYT T + + W ++++++ R+ L +E RQ+ N++LR++
Sbjct: 2153 LDRQIKSFRV---ASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQE 2209
Query: 635 FGAQANVIGPWIQTKMEEI--GRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDH 692
F AN WIQ + G +E GTLE QL ++ + I + ++ ++E
Sbjct: 2210 FAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLG 2269
Query: 693 QLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFR 752
++EALI DNK+T ++ + W+QL R + +E QI R+ G+++E + EF
Sbjct: 2270 AAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFS 2329
Query: 753 ASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQGE--AEFARIMSIVDPNRLGVVTFQ 810
F HFD+D SG L +EFK+CL SLGYD+ +GE EF I+ VDPNR G V+ Q
Sbjct: 2330 MMFKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDGHVSLQ 2389
Query: 811 AFIDFM-SRETADTDTADQVMASFKILAGD-KNYITMDELRRELPPDQAEYCIARMAPYT 868
++ FM SRET + +++++ ++F+ L+ + K Y+T +EL + L +QA+YC++ M PY
Sbjct: 2390 EYMAFMISRETENVKSSEEIESAFRALSSEGKPYVTKEELYQNLTREQADYCVSHMKPYV 2449
Query: 869 GPD--SVPGALDYMSFSTALY 887
+P A DY+ F+ +L+
Sbjct: 2450 DGKGRELPTAFDYVEFTRSLF 2470
Score = 83.6 bits (205), Expect = 8e-16
Identities = 83/382 (21%), Positives = 162/382 (42%), Gaps = 47/382 (12%)
Query: 388 RLERLDHLAE--KFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLA 445
R +RL+ E +F EAW + K ++ +DY TL+ I+ LLKKHEAFE+D
Sbjct: 1862 RGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGD-TLAAIQGLLKKHEAFETDFT 1920
Query: 446 AHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLE 505
H+DRV + Q+L + + + +++++ + + G ++ + A +R KL E
Sbjct: 1921 VHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGL------NGKVSDLEKAAAQRKAKLDE 1974
Query: 506 TIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKER 565
+ +L++ +A +W+ L+ + +Q L T E F A L +E
Sbjct: 1975 --NSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEG 2032
Query: 566 LA--------ILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQA 617
+A +L + SK ++ H ++ +W + R +
Sbjct: 2033 IANITALKDQLLAAKHVQSKAIEARHASLM--------------KRWSQLLANSAARKKK 2078
Query: 618 LTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQ---- 673
L E + + E L F +A+ W + E+ ++ + +++ LR+
Sbjct: 2079 LLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEED---LTDPVRCNSLEEIKALREAHDA 2135
Query: 674 YEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVEN 733
+ S+ + + +QL + I+ + N +T +TME + W L + I E E
Sbjct: 2136 FRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNL----QKIIKEREL 2191
Query: 734 QILTRDAKGISQEQMNEFRASF 755
++ + QE+ ++ R F
Sbjct: 2192 ELQKEQRR---QEENDKLRQEF 2210
Score = 60.8 bits (146), Expect = 5e-09
Identities = 82/385 (21%), Positives = 153/385 (39%), Gaps = 41/385 (10%)
Query: 274 QLMEDYEKLA-SDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKC 332
Q++E KL S L+ R + +E + E A + +D + + H+ + E
Sbjct: 1539 QMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQSKHQKHQAFE-A 1597
Query: 333 QLEINFNTLQTKLRLSN----RPAFMPSEGRM---VSDINNAWGCLEQVEKGYEEWLLNE 385
+L N + ++ + + N R A SE + ++ + + W L Q + + L E
Sbjct: 1598 ELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQ-KSAEKSQKLKE 1656
Query: 386 IRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLA 445
+ + + + F + W EA+L +DY L+ + LLKKH+ E+D++
Sbjct: 1657 ANKQQNFNTGIKDF-------DFWLSEVEALLASEDYGK-DLASVNNLLKKHQLLEADIS 1708
Query: 446 AHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLE 505
AH+DR++ + + A L +D+ V + I ++ + ++ RR L + +L +
Sbjct: 1709 AHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQ 1768
Query: 506 TIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKER 565
+ E +W++ + + +Q L H++ +A L +
Sbjct: 1769 FFRDMDDE--------ESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEP-- 1818
Query: 566 LAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQ 625
AI G+ + K+ N G Q + W ++QL R Q L E Q
Sbjct: 1819 -AIQGVLDTGKKLSDD---NTIGKEEIQQRLAQFVE-HWKELKQLAAARGQRLEESLEYQ 1873
Query: 626 QHNERLRKQFGAQANVIGPWIQTKM 650
QF A WI KM
Sbjct: 1874 --------QFVANVEEEEAWINEKM 1890
Score = 60.1 bits (144), Expect = 9e-09
Identities = 54/250 (21%), Positives = 109/250 (43%), Gaps = 19/250 (7%)
Query: 386 IRRLERLDHLAEK--FRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESD 443
++R LD E F + E W +EA L +D + +L ++AL+KKHE F+
Sbjct: 1435 VQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTED-KGDSLDSVEALIKKHEDFDKA 1493
Query: 444 LAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKL 503
+ ++++ + A A +L +Y +++R ++ D+W L A + +E+ KL
Sbjct: 1494 INVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKA------QMIEKRSKL 1547
Query: 504 LETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATL-PDAD 562
E+ Q ++++ W+ ++ D IQ H+ F+A L +AD
Sbjct: 1548 GES--QTLQQFSRDVDEIEAWISEKLQTASDESYKDP-TNIQSKHQKHQAFEAELHANAD 1604
Query: 563 KERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEH 622
+ I G+ + + +++ AG+ + +W + Q + Q L E +
Sbjct: 1605 R----IRGVIDMGNSLIE--RGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEAN 1658
Query: 623 ARQQHNERLR 632
+Q N ++
Sbjct: 1659 KQQNFNTGIK 1668
Score = 58.9 bits (141), Expect = 2e-08
Identities = 72/348 (20%), Positives = 142/348 (40%), Gaps = 49/348 (14%)
Query: 383 LNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFES 442
LN+ RL+R LA+ FR S W +A++ D + ++ +ALL +H+ +
Sbjct: 357 LNDSYRLQRF--LAD-FRDLTS----WVTEMKALINA-DELASDVAGAEALLDRHQEHKG 408
Query: 443 DLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEK 502
++ AH+D + Q L +Y S V + + ++ L L + RR+ E+
Sbjct: 409 EIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMD 468
Query: 503 LLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDAD 562
L QL+ ++ +NWM L + + +++ ++ L HE F+ +L A
Sbjct: 469 L-----QLFYRDTEQV---DNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSL-SAQ 519
Query: 563 KERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEH 622
+E+ I + +K++Q H M + RRD L+ +
Sbjct: 520 EEK--ITALDEFATKLIQNNHYAM---------------------EDVATRRDALLSRRN 556
Query: 623 ARQQHNERLR---------KQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQ 673
A + R R +QF ++ + W+ KM+ + + L+ ++ +
Sbjct: 557 ALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQA 616
Query: 674 YEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLL 721
+E + + +ID LE Q + + + M + W++LL
Sbjct: 617 FEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLL 664
Score = 58.9 bits (141), Expect = 2e-08
Identities = 36/137 (26%), Positives = 63/137 (45%), Gaps = 9/137 (6%)
Query: 361 VSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQK 420
+ ++N W L+Q L E +L H ++F + A + W + K L
Sbjct: 1208 IKELNERWRSLQQ--------LAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTD 1259
Query: 421 DYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKIC 480
+Y L+ ++AL +KHE FE DLAA D+V + A+ L + + + +C ++
Sbjct: 1260 NYGH-DLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELN 1318
Query: 481 DQWDNLGALTQKRREAL 497
W +LG +R+ L
Sbjct: 1319 QAWSSLGKRADQRKAKL 1335
Score = 57.0 bits (136), Expect = 8e-08
Identities = 68/347 (19%), Positives = 143/347 (41%), Gaps = 31/347 (8%)
Query: 383 LNEIRRLERLDHLAEKFRQK-ASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFE 441
L+ +RR + D +F Q+ A E W K + ++Y+ T ++ L+KH+AFE
Sbjct: 32 LSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENYKDPT--NLQGKLQKHQAFE 89
Query: 442 SDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTE 501
+++ A+ + ++ + ++ S ++ R ++ QW+ L +K R E+
Sbjct: 90 AEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWE---LLLEKMR---EKGI 143
Query: 502 KLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDA 561
KLL+ Q ++Y + +W+ + + +E ++ L E+F+ + A
Sbjct: 144 KLLQA--QKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMA-A 200
Query: 562 DKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEE 621
+ER + ++ +K++Q H E+N W ++ L +R L
Sbjct: 201 HEER--VNEVNQFAAKLIQEQHPE----EELIKTKQDEVNAAWQRLKGLALQRQGKLFGA 254
Query: 622 HARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQY---EKSI 678
Q+ N + + WI+ K + + S + L + LR++ E+ +
Sbjct: 255 AEVQRFNRDVDETIS--------WIKEKEQLMA--SDDFGRDLASVQALLRKHEGLERDL 304
Query: 679 VNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIA 725
+ K+ L + +Q++ E + WEQ+ T A
Sbjct: 305 AALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAA 351
Score = 57.0 bits (136), Expect = 8e-08
Identities = 53/235 (22%), Positives = 102/235 (43%), Gaps = 25/235 (10%)
Query: 274 QLMEDYEKLASDLLEWIR-RTIPWLENRVPENTMHA--MQQKLEDFRDYRRLHKPPKVQE 330
Q + Y + D+++WI + + ++ H +Q+K E+F+ H+ +V E
Sbjct: 149 QKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEE-RVNE 207
Query: 331 KCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLE 390
N KL P + + ++N AW L+ + ++R
Sbjct: 208 -------VNQFAAKLIQEQHPEEELIKTKQ-DEVNAAWQRLKGLA----------LQRQG 249
Query: 391 RLDHLAEKFRQKASIHE--AWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQ 448
+L AE R + E +W KE ++ D+ L+ ++ALL+KHE E DLAA +
Sbjct: 250 KLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGR-DLASVQALLRKHEGLERDLAALE 308
Query: 449 DRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKL 503
D+V+ + A A L + + + + +++ W+ + L +R L + +L
Sbjct: 309 DKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRL 363
Score = 57.0 bits (136), Expect = 8e-08
Identities = 57/286 (19%), Positives = 118/286 (41%), Gaps = 31/286 (10%)
Query: 397 EKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAA 456
++F + E W E L DY L+ ++ L KKH E+D+AAHQDR++ I
Sbjct: 681 QQFNRNVEDIELWLYEVEGHLASDDYGK-DLTNVQNLQKKHALLEADVAAHQDRIDGITI 739
Query: 457 IAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLET--IDQLYLEY 514
A++ + ++D+ ++ + + + +++ L + + R +KL ++ + QL+ +
Sbjct: 740 QARQFQDAGHFDAENIKKKQEALVARYEAL------KEPMVARKQKLADSLRLQQLFRDV 793
Query: 515 AKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNE 574
W+ T + +Q L H+ +A + + I + +
Sbjct: 794 EDE----ETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPR---IKAVTQK 846
Query: 575 VSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQ 634
+ +V+ H E+N KW+ ++ +R Q L + Q Q
Sbjct: 847 GNAMVEEGHFAAEDVKAKL----HELNQKWEALKAKASQRRQDLEDSLQAQ--------Q 894
Query: 635 FGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVN 680
+ A AN W++ K +G +G ED L + +++++
Sbjct: 895 YFADANEAESWMREKEPIVGSTD---YGKDEDSAEALLKKHEALMS 937
Score = 54.3 bits (129), Expect = 5e-07
Identities = 65/317 (20%), Positives = 127/317 (40%), Gaps = 34/317 (10%)
Query: 409 WTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYD 468
W +EA L +D + L ++ALLKKHE FE L+A ++++ + A +L + ++Y
Sbjct: 482 WMSKQEAFLLNEDLGDS-LDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYA 540
Query: 469 SPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYL-EYAKRAAPFNNWMEG 527
V R + + + L +RR L D +L ++ + + +W+
Sbjct: 541 MEDVATRRDALLSRRNALHERAMRRRAQL---------ADSFHLQQFFRDSDELKSWVNE 591
Query: 528 AMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMA 587
M+ D +QG H+ F+A L A++ R+ L K++ H
Sbjct: 592 KMKTATDE-AYKDPSNLQGKVQKHQAFEAEL-SANQSRIDAL--EKAGQKLIDVNHY--- 644
Query: 588 GTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQ 647
E+ W + + + L E + +QQ N + I W+
Sbjct: 645 -AKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVED--------IELWL- 694
Query: 648 TKMEEIGRISIEMHGTLEDQLSHLRQ----YEKSIVNYKPKIDQLEGDHQLIQEALIFDN 703
E G ++ + +G + +L++ E + ++ +ID + + Q+A FD
Sbjct: 695 --YEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDA 752
Query: 704 KHTNYTMEHIRVGWEQL 720
++ E + +E L
Sbjct: 753 ENIKKKQEALVARYEAL 769
Score = 51.6 bits (122), Expect = 3e-06
Identities = 33/121 (27%), Positives = 64/121 (52%), Gaps = 9/121 (7%)
Query: 387 RRLERLD--HLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDL 444
RR + D HL + FR + ++W + K + Y+ S ++ ++KH+AFE++L
Sbjct: 565 RRAQLADSFHLQQFFRDSDEL-KSWVNEKMKTATDEAYKDP--SNLQGKVQKHQAFEAEL 621
Query: 445 AAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQ----KRREALERT 500
+A+Q R++ + Q+L ++++Y V AR ++ W L T+ K REA ++
Sbjct: 622 SANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQ 681
Query: 501 E 501
+
Sbjct: 682 Q 682
Score = 51.6 bits (122), Expect = 3e-06
Identities = 65/326 (19%), Positives = 136/326 (41%), Gaps = 54/326 (16%)
Query: 339 NTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEK 398
N L+ + ++ R + ++ R+ + + ++QVE+ Y L +R L+ +K
Sbjct: 1034 NLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKK 1093
Query: 399 FR--QKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAA 456
F ++A+ + W + KEA L ++ A L +++ L KK + F+ DL A++ R++ I
Sbjct: 1094 FMLFREANELQQWINEKEAALTSEEVG-ADLEQVEVLQKKFDDFQKDLKANESRLKDINK 1152
Query: 457 IAQELN-------------ELDYYD------------SPSVNARC-----------QKIC 480
+A++L + + Y SP +AR +++
Sbjct: 1153 VAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELN 1212
Query: 481 DQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHT 540
++W +L L ++R + L ++ + + A W+E + L H
Sbjct: 1213 ERWRSLQQLAEERSQLLGSAHEVQR--------FHRDADETKEWIEEKNQALNTDNYGHD 1264
Query: 541 IEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEI 600
+ +Q L HE F+ L A +++ LG +++Q++ + T E+
Sbjct: 1265 LASVQALQRKHEGFERDLA-ALGDKVNSLG--ETAERLIQSHPESAEDLQEKCT----EL 1317
Query: 601 NGKWDHVRQLVPRRDQALTEEHARQQ 626
N W + + +R L + H Q+
Sbjct: 1318 NQAWSSLGKRADQRKAKLGDSHDLQR 1343
Score = 48.5 bits (114), Expect = 3e-05
Identities = 27/114 (23%), Positives = 59/114 (51%), Gaps = 8/114 (7%)
Query: 391 RLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSE------IKALLKKHEAFESDL 444
R LA+ R + + + +E +R+K+ A+ + ++ LLKKH+A ++++
Sbjct: 776 RKQKLADSLRLQQLFRDV--EDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEI 833
Query: 445 AAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALE 498
A H+ R++ + + E ++ + V A+ ++ +W+ L A +RR+ LE
Sbjct: 834 AGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLE 887
Score = 40.4 bits (93), Expect = 0.007
Identities = 55/290 (18%), Positives = 115/290 (39%), Gaps = 32/290 (11%)
Query: 362 SDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKD 421
+++N AW L + + L + L+R FR S W +G ++ D
Sbjct: 1315 TELNQAWSSLGK-RADQRKAKLGDSHDLQRF---LSDFRDLMS----WINGIRGLV-SSD 1365
Query: 422 YETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICD 481
++ +ALL++H+ +++ A + Q+L +Y SP + + +
Sbjct: 1366 ELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQ 1425
Query: 482 QWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTI 541
+ +L +RR L++ +L QL+ ++A NWM L ++
Sbjct: 1426 ERADLEKAWVQRRMMLDQCLEL-----QLFHRDCEQA---ENWMAAREAFLNTEDKGDSL 1477
Query: 542 EEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEIN 601
+ ++ L HE F + + +E++A L Q + + Y +I+
Sbjct: 1478 DSVEALIKKHEDFDKAI-NVQEEKIAAL----------QAFADQLIAAGHY---AKGDIS 1523
Query: 602 GKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKME 651
+ + V R + E+ ++ ++ L +QF + I WI K++
Sbjct: 1524 SRRNEVLDRWRRLKAQMIEKRSKLGESQTL-QQFSRDVDEIEAWISEKLQ 1572
Score = 38.5 bits (88), Expect = 0.028
Identities = 27/78 (34%), Positives = 42/78 (53%), Gaps = 2/78 (2%)
Query: 387 RRLERLDHL-AEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLA 445
RR + D L A+++ A+ E+W KE ++ DY S +ALLKKHEA SDL+
Sbjct: 882 RRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSA-EALLKKHEALMSDLS 940
Query: 446 AHQDRVEQIAAIAQELNE 463
A+ ++ + AQ +
Sbjct: 941 AYGSSIQALREQAQSCRQ 958
Score = 31.6 bits (70), Expect = 3.4
Identities = 52/256 (20%), Positives = 103/256 (40%), Gaps = 52/256 (20%)
Query: 432 ALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYY-----DSPSVNARCQKICDQWDNL 486
A +KK + +S A+ ++ +E+ +IA ++D ++ SV+ R +++ + + +L
Sbjct: 1019 AYVKKLDPAQS--ASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSL 1076
Query: 487 GALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQG 546
L +KR+ LE++ K + A W+ L + +E+++
Sbjct: 1077 LELGEKRKGMLEKSCKKFMLF--------REANELQQWINEKEAALTSEEVGADLEQVEV 1128
Query: 547 LTTAHEQFK-------ATLPDADK--ERLAILGIHNEVSKIVQTYHV---------NMAG 588
L + F+ + L D +K E L G+ E + VQ V +
Sbjct: 1129 LQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKT 1188
Query: 589 TNPY-----------TTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGA 637
+P+ T + +E+N +W ++QL R Q L H Q +F
Sbjct: 1189 ASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQ--------RFHR 1240
Query: 638 QANVIGPWIQTKMEEI 653
A+ WI+ K + +
Sbjct: 1241 DADETKEWIEEKNQAL 1256
>gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
isoform 1 [Homo sapiens]
Length = 2477
Score = 288 bits (738), Expect = 1e-77
Identities = 167/501 (33%), Positives = 282/501 (56%), Gaps = 21/501 (4%)
Query: 398 KFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAA-HQDRVEQIAA 456
+F KA + E+W KE L+ DY LS ++ LL K E F++ L A Q+ + I A
Sbjct: 1985 QFNWKADVVESWIGEKENSLKTDDYGR-DLSSVQTLLTKQETFDAGLQAFQQEGIANITA 2043
Query: 457 IAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAK 516
+ +L + S ++ AR + +W L A + R++ L + ++ L+L +AK
Sbjct: 2044 LKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAK 2103
Query: 517 RAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDA--DKERLAILGIHNE 574
+A+ FN+W E A EDL D +++EEI+ L AH+ F+++L A D +LA E
Sbjct: 2104 KASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLA------E 2157
Query: 575 VSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQ 634
+ + ++++ V +NPYT T + + W ++++++ R+ L +E RQ+ N++LR++
Sbjct: 2158 LDRQIKSFRV---ASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQE 2214
Query: 635 FGAQANVIGPWIQTKMEEI--GRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDH 692
F AN WIQ + G +E GTLE QL ++ + I + ++ ++E
Sbjct: 2215 FAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLG 2274
Query: 693 QLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFR 752
++EALI DNK+T ++ + W+QL R + +E QI R+ G+++E + EF
Sbjct: 2275 AAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFS 2334
Query: 753 ASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQGE--AEFARIMSIVDPNRLGVVTFQ 810
F HFD+D SG L +EFK+CL SLGYD+ +GE EF I+ VDPNR G V+ Q
Sbjct: 2335 MMFKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDGHVSLQ 2394
Query: 811 AFIDFM-SRETADTDTADQVMASFKILAGD-KNYITMDELRRELPPDQAEYCIARMAPYT 868
++ FM SRET + +++++ ++F+ L+ + K Y+T +EL + L +QA+YC++ M PY
Sbjct: 2395 EYMAFMISRETENVKSSEEIESAFRALSSEGKPYVTKEELYQNLTREQADYCVSHMKPYV 2454
Query: 869 GPD--SVPGALDYMSFSTALY 887
+P A DY+ F+ +L+
Sbjct: 2455 DGKGRELPTAFDYVEFTRSLF 2475
Score = 83.6 bits (205), Expect = 8e-16
Identities = 83/382 (21%), Positives = 162/382 (42%), Gaps = 47/382 (12%)
Query: 388 RLERLDHLAE--KFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLA 445
R +RL+ E +F EAW + K ++ +DY TL+ I+ LLKKHEAFE+D
Sbjct: 1867 RGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGD-TLAAIQGLLKKHEAFETDFT 1925
Query: 446 AHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLE 505
H+DRV + Q+L + + + +++++ + + G ++ + A +R KL E
Sbjct: 1926 VHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGL------NGKVSDLEKAAAQRKAKLDE 1979
Query: 506 TIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKER 565
+ +L++ +A +W+ L+ + +Q L T E F A L +E
Sbjct: 1980 --NSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEG 2037
Query: 566 LA--------ILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQA 617
+A +L + SK ++ H ++ +W + R +
Sbjct: 2038 IANITALKDQLLAAKHVQSKAIEARHASLM--------------KRWSQLLANSAARKKK 2083
Query: 618 LTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQ---- 673
L E + + E L F +A+ W + E+ ++ + +++ LR+
Sbjct: 2084 LLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEED---LTDPVRCNSLEEIKALREAHDA 2140
Query: 674 YEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVEN 733
+ S+ + + +QL + I+ + N +T +TME + W L + I E E
Sbjct: 2141 FRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNL----QKIIKEREL 2196
Query: 734 QILTRDAKGISQEQMNEFRASF 755
++ + QE+ ++ R F
Sbjct: 2197 ELQKEQRR---QEENDKLRQEF 2215
Score = 60.1 bits (144), Expect = 9e-09
Identities = 50/250 (20%), Positives = 110/250 (44%), Gaps = 14/250 (5%)
Query: 386 IRRLERLDHLAEK--FRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESD 443
++R LD E F + E W +EA L +D + +L ++AL+KKHE F+
Sbjct: 1435 VQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTED-KGDSLDSVEALIKKHEDFDKA 1493
Query: 444 LAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKL 503
+ ++++ + A A +L +Y +++R ++ D+W L A + +E+ KL
Sbjct: 1494 INVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKA------QMIEKRSKL 1547
Query: 504 LETIDQLYLEYAKRAAPFNNWMEGAMEDLQD-TFIVHTIEEIQGLTTAHEQFKATLPDAD 562
E+ Q ++++ W+ ++ D ++ T ++ L + H++ +A +
Sbjct: 1548 GES--QTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELH 1605
Query: 563 KERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEH 622
I G+ + + +++ AG+ + +W + Q + Q L E +
Sbjct: 1606 ANADRIRGVIDMGNSLIE--RGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEAN 1663
Query: 623 ARQQHNERLR 632
+Q N ++
Sbjct: 1664 KQQNFNTGIK 1673
Score = 58.9 bits (141), Expect = 2e-08
Identities = 72/348 (20%), Positives = 142/348 (40%), Gaps = 49/348 (14%)
Query: 383 LNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFES 442
LN+ RL+R LA+ FR S W +A++ D + ++ +ALL +H+ +
Sbjct: 357 LNDSYRLQRF--LAD-FRDLTS----WVTEMKALINA-DELASDVAGAEALLDRHQEHKG 408
Query: 443 DLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEK 502
++ AH+D + Q L +Y S V + + ++ L L + RR+ E+
Sbjct: 409 EIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMD 468
Query: 503 LLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDAD 562
L QL+ ++ +NWM L + + +++ ++ L HE F+ +L A
Sbjct: 469 L-----QLFYRDTEQV---DNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSL-SAQ 519
Query: 563 KERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEH 622
+E+ I + +K++Q H M + RRD L+ +
Sbjct: 520 EEK--ITALDEFATKLIQNNHYAM---------------------EDVATRRDALLSRRN 556
Query: 623 ARQQHNERLR---------KQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQ 673
A + R R +QF ++ + W+ KM+ + + L+ ++ +
Sbjct: 557 ALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQA 616
Query: 674 YEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLL 721
+E + + +ID LE Q + + + M + W++LL
Sbjct: 617 FEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLL 664
Score = 58.9 bits (141), Expect = 2e-08
Identities = 36/137 (26%), Positives = 63/137 (45%), Gaps = 9/137 (6%)
Query: 361 VSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQK 420
+ ++N W L+Q L E +L H ++F + A + W + K L
Sbjct: 1208 IKELNERWRSLQQ--------LAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTD 1259
Query: 421 DYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKIC 480
+Y L+ ++AL +KHE FE DLAA D+V + A+ L + + + +C ++
Sbjct: 1260 NYGH-DLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELN 1318
Query: 481 DQWDNLGALTQKRREAL 497
W +LG +R+ L
Sbjct: 1319 QAWSSLGKRADQRKAKL 1335
Score = 57.4 bits (137), Expect = 6e-08
Identities = 84/389 (21%), Positives = 154/389 (39%), Gaps = 44/389 (11%)
Query: 274 QLMEDYEKLA-SDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDY---RRLHKPPKVQ 329
Q++E KL S L+ R + +E + E A + +D + + L K K Q
Sbjct: 1539 QMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQ 1598
Query: 330 E-KCQLEINFNTLQTKLRLSN----RPAFMPSEGRM---VSDINNAWGCLEQVEKGYEEW 381
+ +L N + ++ + + N R A SE + ++ + + W L Q + +
Sbjct: 1599 AFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQ-KSAEKSQ 1657
Query: 382 LLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFE 441
L E + + + + F + W EA+L +DY L+ + LLKKH+ E
Sbjct: 1658 KLKEANKQQNFNTGIKDF-------DFWLSEVEALLASEDYGK-DLASVNNLLKKHQLLE 1709
Query: 442 SDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTE 501
+D++AH+DR++ + + A L +D+ V + I ++ + ++ RR L +
Sbjct: 1710 ADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESH 1769
Query: 502 KLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDA 561
+L + + E +W++ + + +Q L H++ +A L
Sbjct: 1770 RLHQFFRDMDDE--------ESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAH 1821
Query: 562 DKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEE 621
+ AI G+ + K+ N G Q + W ++QL R Q L E
Sbjct: 1822 EP---AIQGVLDTGKKLSDD---NTIGKEEIQQRLAQFVE-HWKELKQLAAARGQRLEES 1874
Query: 622 HARQQHNERLRKQFGAQANVIGPWIQTKM 650
Q QF A WI KM
Sbjct: 1875 LEYQ--------QFVANVEEEEAWINEKM 1895
Score = 57.0 bits (136), Expect = 8e-08
Identities = 68/347 (19%), Positives = 143/347 (41%), Gaps = 31/347 (8%)
Query: 383 LNEIRRLERLDHLAEKFRQK-ASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFE 441
L+ +RR + D +F Q+ A E W K + ++Y+ T ++ L+KH+AFE
Sbjct: 32 LSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENYKDPT--NLQGKLQKHQAFE 89
Query: 442 SDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTE 501
+++ A+ + ++ + ++ S ++ R ++ QW+ L +K R E+
Sbjct: 90 AEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWE---LLLEKMR---EKGI 143
Query: 502 KLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDA 561
KLL+ Q ++Y + +W+ + + +E ++ L E+F+ + A
Sbjct: 144 KLLQA--QKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMA-A 200
Query: 562 DKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEE 621
+ER + ++ +K++Q H E+N W ++ L +R L
Sbjct: 201 HEER--VNEVNQFAAKLIQEQHPE----EELIKTKQDEVNAAWQRLKGLALQRQGKLFGA 254
Query: 622 HARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQY---EKSI 678
Q+ N + + WI+ K + + S + L + LR++ E+ +
Sbjct: 255 AEVQRFNRDVDETIS--------WIKEKEQLMA--SDDFGRDLASVQALLRKHEGLERDL 304
Query: 679 VNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIA 725
+ K+ L + +Q++ E + WEQ+ T A
Sbjct: 305 AALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAA 351
Score = 57.0 bits (136), Expect = 8e-08
Identities = 53/235 (22%), Positives = 102/235 (43%), Gaps = 25/235 (10%)
Query: 274 QLMEDYEKLASDLLEWIR-RTIPWLENRVPENTMHA--MQQKLEDFRDYRRLHKPPKVQE 330
Q + Y + D+++WI + + ++ H +Q+K E+F+ H+ +V E
Sbjct: 149 QKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEE-RVNE 207
Query: 331 KCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLE 390
N KL P + + ++N AW L+ + ++R
Sbjct: 208 -------VNQFAAKLIQEQHPEEELIKTKQ-DEVNAAWQRLKGLA----------LQRQG 249
Query: 391 RLDHLAEKFRQKASIHE--AWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQ 448
+L AE R + E +W KE ++ D+ L+ ++ALL+KHE E DLAA +
Sbjct: 250 KLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGR-DLASVQALLRKHEGLERDLAALE 308
Query: 449 DRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKL 503
D+V+ + A A L + + + + +++ W+ + L +R L + +L
Sbjct: 309 DKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRL 363
Score = 57.0 bits (136), Expect = 8e-08
Identities = 57/286 (19%), Positives = 118/286 (41%), Gaps = 31/286 (10%)
Query: 397 EKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAA 456
++F + E W E L DY L+ ++ L KKH E+D+AAHQDR++ I
Sbjct: 681 QQFNRNVEDIELWLYEVEGHLASDDYGK-DLTNVQNLQKKHALLEADVAAHQDRIDGITI 739
Query: 457 IAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLET--IDQLYLEY 514
A++ + ++D+ ++ + + + +++ L + + R +KL ++ + QL+ +
Sbjct: 740 QARQFQDAGHFDAENIKKKQEALVARYEAL------KEPMVARKQKLADSLRLQQLFRDV 793
Query: 515 AKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNE 574
W+ T + +Q L H+ +A + + I + +
Sbjct: 794 EDE----ETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPR---IKAVTQK 846
Query: 575 VSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQ 634
+ +V+ H E+N KW+ ++ +R Q L + Q Q
Sbjct: 847 GNAMVEEGHFAAEDVKAKL----HELNQKWEALKAKASQRRQDLEDSLQAQ--------Q 894
Query: 635 FGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVN 680
+ A AN W++ K +G +G ED L + +++++
Sbjct: 895 YFADANEAESWMREKEPIVGSTD---YGKDEDSAEALLKKHEALMS 937
Score = 54.3 bits (129), Expect = 5e-07
Identities = 65/317 (20%), Positives = 127/317 (40%), Gaps = 34/317 (10%)
Query: 409 WTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYD 468
W +EA L +D + L ++ALLKKHE FE L+A ++++ + A +L + ++Y
Sbjct: 482 WMSKQEAFLLNEDLGDS-LDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYA 540
Query: 469 SPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYL-EYAKRAAPFNNWMEG 527
V R + + + L +RR L D +L ++ + + +W+
Sbjct: 541 MEDVATRRDALLSRRNALHERAMRRRAQL---------ADSFHLQQFFRDSDELKSWVNE 591
Query: 528 AMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMA 587
M+ D +QG H+ F+A L A++ R+ L K++ H
Sbjct: 592 KMKTATDE-AYKDPSNLQGKVQKHQAFEAEL-SANQSRIDAL--EKAGQKLIDVNHY--- 644
Query: 588 GTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQ 647
E+ W + + + L E + +QQ N + I W+
Sbjct: 645 -AKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVED--------IELWL- 694
Query: 648 TKMEEIGRISIEMHGTLEDQLSHLRQ----YEKSIVNYKPKIDQLEGDHQLIQEALIFDN 703
E G ++ + +G + +L++ E + ++ +ID + + Q+A FD
Sbjct: 695 --YEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDA 752
Query: 704 KHTNYTMEHIRVGWEQL 720
++ E + +E L
Sbjct: 753 ENIKKKQEALVARYEAL 769
Score = 51.6 bits (122), Expect = 3e-06
Identities = 33/121 (27%), Positives = 64/121 (52%), Gaps = 9/121 (7%)
Query: 387 RRLERLD--HLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDL 444
RR + D HL + FR + ++W + K + Y+ S ++ ++KH+AFE++L
Sbjct: 565 RRAQLADSFHLQQFFRDSDEL-KSWVNEKMKTATDEAYKDP--SNLQGKVQKHQAFEAEL 621
Query: 445 AAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQ----KRREALERT 500
+A+Q R++ + Q+L ++++Y V AR ++ W L T+ K REA ++
Sbjct: 622 SANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQ 681
Query: 501 E 501
+
Sbjct: 682 Q 682
Score = 51.6 bits (122), Expect = 3e-06
Identities = 65/326 (19%), Positives = 136/326 (41%), Gaps = 54/326 (16%)
Query: 339 NTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEK 398
N L+ + ++ R + ++ R+ + + ++QVE+ Y L +R L+ +K
Sbjct: 1034 NLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKK 1093
Query: 399 FR--QKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAA 456
F ++A+ + W + KEA L ++ A L +++ L KK + F+ DL A++ R++ I
Sbjct: 1094 FMLFREANELQQWINEKEAALTSEEVG-ADLEQVEVLQKKFDDFQKDLKANESRLKDINK 1152
Query: 457 IAQELN-------------ELDYYD------------SPSVNARC-----------QKIC 480
+A++L + + Y SP +AR +++
Sbjct: 1153 VAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELN 1212
Query: 481 DQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHT 540
++W +L L ++R + L ++ + + A W+E + L H
Sbjct: 1213 ERWRSLQQLAEERSQLLGSAHEVQR--------FHRDADETKEWIEEKNQALNTDNYGHD 1264
Query: 541 IEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEI 600
+ +Q L HE F+ L A +++ LG +++Q++ + T E+
Sbjct: 1265 LASVQALQRKHEGFERDLA-ALGDKVNSLG--ETAERLIQSHPESAEDLQEKCT----EL 1317
Query: 601 NGKWDHVRQLVPRRDQALTEEHARQQ 626
N W + + +R L + H Q+
Sbjct: 1318 NQAWSSLGKRADQRKAKLGDSHDLQR 1343
Score = 48.5 bits (114), Expect = 3e-05
Identities = 27/114 (23%), Positives = 59/114 (51%), Gaps = 8/114 (7%)
Query: 391 RLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSE------IKALLKKHEAFESDL 444
R LA+ R + + + +E +R+K+ A+ + ++ LLKKH+A ++++
Sbjct: 776 RKQKLADSLRLQQLFRDV--EDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEI 833
Query: 445 AAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALE 498
A H+ R++ + + E ++ + V A+ ++ +W+ L A +RR+ LE
Sbjct: 834 AGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLE 887
Score = 40.4 bits (93), Expect = 0.007
Identities = 55/290 (18%), Positives = 115/290 (39%), Gaps = 32/290 (11%)
Query: 362 SDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKD 421
+++N AW L + + L + L+R FR S W +G ++ D
Sbjct: 1315 TELNQAWSSLGK-RADQRKAKLGDSHDLQRF---LSDFRDLMS----WINGIRGLV-SSD 1365
Query: 422 YETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICD 481
++ +ALL++H+ +++ A + Q+L +Y SP + + +
Sbjct: 1366 ELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQ 1425
Query: 482 QWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTI 541
+ +L +RR L++ +L QL+ ++A NWM L ++
Sbjct: 1426 ERADLEKAWVQRRMMLDQCLEL-----QLFHRDCEQA---ENWMAAREAFLNTEDKGDSL 1477
Query: 542 EEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEIN 601
+ ++ L HE F + + +E++A L Q + + Y +I+
Sbjct: 1478 DSVEALIKKHEDFDKAI-NVQEEKIAAL----------QAFADQLIAAGHY---AKGDIS 1523
Query: 602 GKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKME 651
+ + V R + E+ ++ ++ L +QF + I WI K++
Sbjct: 1524 SRRNEVLDRWRRLKAQMIEKRSKLGESQTL-QQFSRDVDEIEAWISEKLQ 1572
Score = 38.5 bits (88), Expect = 0.028
Identities = 27/78 (34%), Positives = 42/78 (53%), Gaps = 2/78 (2%)
Query: 387 RRLERLDHL-AEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLA 445
RR + D L A+++ A+ E+W KE ++ DY S +ALLKKHEA SDL+
Sbjct: 882 RRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSA-EALLKKHEALMSDLS 940
Query: 446 AHQDRVEQIAAIAQELNE 463
A+ ++ + AQ +
Sbjct: 941 AYGSSIQALREQAQSCRQ 958
Score = 31.6 bits (70), Expect = 3.4
Identities = 52/256 (20%), Positives = 103/256 (40%), Gaps = 52/256 (20%)
Query: 432 ALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYY-----DSPSVNARCQKICDQWDNL 486
A +KK + +S A+ ++ +E+ +IA ++D ++ SV+ R +++ + + +L
Sbjct: 1019 AYVKKLDPAQS--ASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSL 1076
Query: 487 GALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQG 546
L +KR+ LE++ K + A W+ L + +E+++
Sbjct: 1077 LELGEKRKGMLEKSCKKFMLF--------REANELQQWINEKEAALTSEEVGADLEQVEV 1128
Query: 547 LTTAHEQFK-------ATLPDADK--ERLAILGIHNEVSKIVQTYHV---------NMAG 588
L + F+ + L D +K E L G+ E + VQ V +
Sbjct: 1129 LQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKT 1188
Query: 589 TNPY-----------TTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGA 637
+P+ T + +E+N +W ++QL R Q L H Q +F
Sbjct: 1189 ASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQ--------RFHR 1240
Query: 638 QANVIGPWIQTKMEEI 653
A+ WI+ K + +
Sbjct: 1241 DADETKEWIEEKNQAL 1256
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 242 bits (617), Expect = 1e-63
Identities = 147/396 (37%), Positives = 218/396 (55%), Gaps = 23/396 (5%)
Query: 30 EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHK 89
++ Q+KTFT W N HL KA I ++ ED RDG L+ LLEV+SG+ L + E+G+MR HK
Sbjct: 41 DRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFHK 99
Query: 90 ISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISV----EETS 145
+ NV ALD++ + VKLV+I ++I DGN K+TLG+IWTIIL F I DI V E+ +
Sbjct: 100 LQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMT 159
Query: 146 AKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNL 205
AKE LLLW QR Y+ + NF SW+DG F A+IHRH+P LID K+ + L NL
Sbjct: 160 AKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENL 219
Query: 206 NTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKV 265
+ AF VAE+ L + ++LD ED V +PDEK+I+TYVSS Y A +
Sbjct: 220 DQAFSVAERDLGVTRLLDPED-VDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRA---- 274
Query: 266 LAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKP 325
E + ++Y +L LL+W+R E R ++ ++ F ++ + P
Sbjct: 275 ----NELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELP 330
Query: 326 PKVQEKCQLEINFNTLQTKL---RLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWL 382
K +K + + + +L+ + +L P + P D+ WG L E+ L
Sbjct: 331 AKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHP------LDVEKEWGKLHVAILEREKQL 384
Query: 383 LNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLR 418
+E RLE L + K + +A + E + +A+L+
Sbjct: 385 RSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQ 420
Score = 34.3 bits (77), Expect = 0.53
Identities = 60/293 (20%), Positives = 117/293 (39%), Gaps = 27/293 (9%)
Query: 254 KAETAANRICKVLAVNQENEQLMEDYEKLASDLLE---WIRRTIPWLENRVPENTMHAMQ 310
KAE + K LA Q +L ED E++A L E +RT+ R E + A +
Sbjct: 2326 KAEAELLQQQKELAQEQAR-RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2384
Query: 311 QKL---EDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNA 367
KL E R R + + K EI +T+L + + +
Sbjct: 2385 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE--------- 2435
Query: 368 WGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASI-----HEAWTDGKEAMLRQKD- 421
+++ + ++ L E + L+ EK +Q+A + E T +E +L++
Sbjct: 2436 ---IQRQQSDHDAERLREA--IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2490
Query: 422 YETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICD 481
+ + LSE +LL++ E + A + + A AQ+L E + Q++
Sbjct: 2491 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2550
Query: 482 QWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQD 534
+ + E + R ++ L+ ++Q + + A N + ++ L++
Sbjct: 2551 SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE 2603
Score = 30.4 bits (67), Expect = 7.7
Identities = 56/302 (18%), Positives = 118/302 (39%), Gaps = 47/302 (15%)
Query: 210 DVAEKYLDIPKMLDAE---------DIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAAN 260
D+ E+ + K D+E D + R E+ I+ +SF A +G + E
Sbjct: 1890 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1949
Query: 261 RICK----VLAVNQENE-------QLMEDYEKLASDLLEWIRRTIPWLEN--RVPENTMH 307
RI L ++ E QL + E+ + E +++++ E R + +
Sbjct: 1950 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2009
Query: 308 AMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRP---AFMPSEGRMVSDI 364
+++ + RRL + + + QL++ Q +L+ + A E + +
Sbjct: 2010 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2069
Query: 365 NNAWGCLEQV-----------EKGYEEWLLNE------IRRLERLDHLAEKFRQKASIHE 407
L+Q+ E+ E + E R++E + L + ++A
Sbjct: 2070 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2129
Query: 408 AWTDGKEAMLRQKDYETATLSEI-KALLKKHEAFESDLAAHQDRVEQI----AAIAQELN 462
E + ++ + E A ++ +A L++ +A ++++ H+ EQ A + QEL
Sbjct: 2130 QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2189
Query: 463 EL 464
L
Sbjct: 2190 TL 2191
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 242 bits (617), Expect = 1e-63
Identities = 147/396 (37%), Positives = 218/396 (55%), Gaps = 23/396 (5%)
Query: 30 EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHK 89
++ Q+KTFT W N HL KA I ++ ED RDG L+ LLEV+SG+ L + E+G+MR HK
Sbjct: 45 DRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFHK 103
Query: 90 ISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISV----EETS 145
+ NV ALD++ + VKLV+I ++I DGN K+TLG+IWTIIL F I DI V E+ +
Sbjct: 104 LQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMT 163
Query: 146 AKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNL 205
AKE LLLW QR Y+ + NF SW+DG F A+IHRH+P LID K+ + L NL
Sbjct: 164 AKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENL 223
Query: 206 NTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKV 265
+ AF VAE+ L + ++LD ED V +PDEK+I+TYVSS Y A +
Sbjct: 224 DQAFSVAERDLGVTRLLDPED-VDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRA---- 278
Query: 266 LAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKP 325
E + ++Y +L LL+W+R E R ++ ++ F ++ + P
Sbjct: 279 ----NELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELP 334
Query: 326 PKVQEKCQLEINFNTLQTKL---RLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWL 382
K +K + + + +L+ + +L P + P D+ WG L E+ L
Sbjct: 335 AKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHP------LDVEKEWGKLHVAILEREKQL 388
Query: 383 LNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLR 418
+E RLE L + K + +A + E + +A+L+
Sbjct: 389 RSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQ 424
Score = 34.3 bits (77), Expect = 0.53
Identities = 60/293 (20%), Positives = 117/293 (39%), Gaps = 27/293 (9%)
Query: 254 KAETAANRICKVLAVNQENEQLMEDYEKLASDLLE---WIRRTIPWLENRVPENTMHAMQ 310
KAE + K LA Q +L ED E++A L E +RT+ R E + A +
Sbjct: 2330 KAEAELLQQQKELAQEQAR-RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2388
Query: 311 QKL---EDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNA 367
KL E R R + + K EI +T+L + + +
Sbjct: 2389 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE--------- 2439
Query: 368 WGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASI-----HEAWTDGKEAMLRQKD- 421
+++ + ++ L E + L+ EK +Q+A + E T +E +L++
Sbjct: 2440 ---IQRQQSDHDAERLREA--IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2494
Query: 422 YETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICD 481
+ + LSE +LL++ E + A + + A AQ+L E + Q++
Sbjct: 2495 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2554
Query: 482 QWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQD 534
+ + E + R ++ L+ ++Q + + A N + ++ L++
Sbjct: 2555 SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE 2607
Score = 30.4 bits (67), Expect = 7.7
Identities = 56/302 (18%), Positives = 118/302 (39%), Gaps = 47/302 (15%)
Query: 210 DVAEKYLDIPKMLDAE---------DIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAAN 260
D+ E+ + K D+E D + R E+ I+ +SF A +G + E
Sbjct: 1894 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1953
Query: 261 RICK----VLAVNQENE-------QLMEDYEKLASDLLEWIRRTIPWLEN--RVPENTMH 307
RI L ++ E QL + E+ + E +++++ E R + +
Sbjct: 1954 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2013
Query: 308 AMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRP---AFMPSEGRMVSDI 364
+++ + RRL + + + QL++ Q +L+ + A E + +
Sbjct: 2014 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2073
Query: 365 NNAWGCLEQV-----------EKGYEEWLLNE------IRRLERLDHLAEKFRQKASIHE 407
L+Q+ E+ E + E R++E + L + ++A
Sbjct: 2074 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2133
Query: 408 AWTDGKEAMLRQKDYETATLSEI-KALLKKHEAFESDLAAHQDRVEQI----AAIAQELN 462
E + ++ + E A ++ +A L++ +A ++++ H+ EQ A + QEL
Sbjct: 2134 QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2193
Query: 463 EL 464
L
Sbjct: 2194 TL 2195
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 242 bits (617), Expect = 1e-63
Identities = 147/396 (37%), Positives = 218/396 (55%), Gaps = 23/396 (5%)
Query: 30 EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHK 89
++ Q+KTFT W N HL KA I ++ ED RDG L+ LLEV+SG+ L + E+G+MR HK
Sbjct: 41 DRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFHK 99
Query: 90 ISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISV----EETS 145
+ NV ALD++ + VKLV+I ++I DGN K+TLG+IWTIIL F I DI V E+ +
Sbjct: 100 LQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMT 159
Query: 146 AKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNL 205
AKE LLLW QR Y+ + NF SW+DG F A+IHRH+P LID K+ + L NL
Sbjct: 160 AKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENL 219
Query: 206 NTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKV 265
+ AF VAE+ L + ++LD ED V +PDEK+I+TYVSS Y A +
Sbjct: 220 DQAFSVAERDLGVTRLLDPED-VDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRA---- 274
Query: 266 LAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKP 325
E + ++Y +L LL+W+R E R ++ ++ F ++ + P
Sbjct: 275 ----NELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELP 330
Query: 326 PKVQEKCQLEINFNTLQTKL---RLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWL 382
K +K + + + +L+ + +L P + P D+ WG L E+ L
Sbjct: 331 AKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHP------LDVEKEWGKLHVAILEREKQL 384
Query: 383 LNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLR 418
+E RLE L + K + +A + E + +A+L+
Sbjct: 385 RSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQ 420
Score = 34.3 bits (77), Expect = 0.53
Identities = 60/293 (20%), Positives = 117/293 (39%), Gaps = 27/293 (9%)
Query: 254 KAETAANRICKVLAVNQENEQLMEDYEKLASDLLE---WIRRTIPWLENRVPENTMHAMQ 310
KAE + K LA Q +L ED E++A L E +RT+ R E + A +
Sbjct: 2326 KAEAELLQQQKELAQEQAR-RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2384
Query: 311 QKL---EDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNA 367
KL E R R + + K EI +T+L + + +
Sbjct: 2385 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE--------- 2435
Query: 368 WGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASI-----HEAWTDGKEAMLRQKD- 421
+++ + ++ L E + L+ EK +Q+A + E T +E +L++
Sbjct: 2436 ---IQRQQSDHDAERLREA--IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2490
Query: 422 YETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICD 481
+ + LSE +LL++ E + A + + A AQ+L E + Q++
Sbjct: 2491 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2550
Query: 482 QWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQD 534
+ + E + R ++ L+ ++Q + + A N + ++ L++
Sbjct: 2551 SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE 2603
Score = 30.4 bits (67), Expect = 7.7
Identities = 56/302 (18%), Positives = 118/302 (39%), Gaps = 47/302 (15%)
Query: 210 DVAEKYLDIPKMLDAE---------DIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAAN 260
D+ E+ + K D+E D + R E+ I+ +SF A +G + E
Sbjct: 1890 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1949
Query: 261 RICK----VLAVNQENE-------QLMEDYEKLASDLLEWIRRTIPWLEN--RVPENTMH 307
RI L ++ E QL + E+ + E +++++ E R + +
Sbjct: 1950 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2009
Query: 308 AMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRP---AFMPSEGRMVSDI 364
+++ + RRL + + + QL++ Q +L+ + A E + +
Sbjct: 2010 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2069
Query: 365 NNAWGCLEQV-----------EKGYEEWLLNE------IRRLERLDHLAEKFRQKASIHE 407
L+Q+ E+ E + E R++E + L + ++A
Sbjct: 2070 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2129
Query: 408 AWTDGKEAMLRQKDYETATLSEI-KALLKKHEAFESDLAAHQDRVEQI----AAIAQELN 462
E + ++ + E A ++ +A L++ +A ++++ H+ EQ A + QEL
Sbjct: 2130 QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2189
Query: 463 EL 464
L
Sbjct: 2190 TL 2191
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 242 bits (617), Expect = 1e-63
Identities = 147/396 (37%), Positives = 218/396 (55%), Gaps = 23/396 (5%)
Query: 30 EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHK 89
++ Q+KTFT W N HL KA I ++ ED RDG L+ LLEV+SG+ L + E+G+MR HK
Sbjct: 9 DRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFHK 67
Query: 90 ISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISV----EETS 145
+ NV ALD++ + VKLV+I ++I DGN K+TLG+IWTIIL F I DI V E+ +
Sbjct: 68 LQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMT 127
Query: 146 AKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNL 205
AKE LLLW QR Y+ + NF SW+DG F A+IHRH+P LID K+ + L NL
Sbjct: 128 AKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENL 187
Query: 206 NTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKV 265
+ AF VAE+ L + ++LD ED V +PDEK+I+TYVSS Y A +
Sbjct: 188 DQAFSVAERDLGVTRLLDPED-VDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRA---- 242
Query: 266 LAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKP 325
E + ++Y +L LL+W+R E R ++ ++ F ++ + P
Sbjct: 243 ----NELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELP 298
Query: 326 PKVQEKCQLEINFNTLQTKL---RLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWL 382
K +K + + + +L+ + +L P + P D+ WG L E+ L
Sbjct: 299 AKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHP------LDVEKEWGKLHVAILEREKQL 352
Query: 383 LNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLR 418
+E RLE L + K + +A + E + +A+L+
Sbjct: 353 RSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQ 388
Score = 34.3 bits (77), Expect = 0.53
Identities = 60/293 (20%), Positives = 117/293 (39%), Gaps = 27/293 (9%)
Query: 254 KAETAANRICKVLAVNQENEQLMEDYEKLASDLLE---WIRRTIPWLENRVPENTMHAMQ 310
KAE + K LA Q +L ED E++A L E +RT+ R E + A +
Sbjct: 2294 KAEAELLQQQKELAQEQAR-RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2352
Query: 311 QKL---EDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNA 367
KL E R R + + K EI +T+L + + +
Sbjct: 2353 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE--------- 2403
Query: 368 WGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASI-----HEAWTDGKEAMLRQKD- 421
+++ + ++ L E + L+ EK +Q+A + E T +E +L++
Sbjct: 2404 ---IQRQQSDHDAERLREA--IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2458
Query: 422 YETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICD 481
+ + LSE +LL++ E + A + + A AQ+L E + Q++
Sbjct: 2459 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2518
Query: 482 QWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQD 534
+ + E + R ++ L+ ++Q + + A N + ++ L++
Sbjct: 2519 SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE 2571
Score = 30.4 bits (67), Expect = 7.7
Identities = 56/302 (18%), Positives = 118/302 (39%), Gaps = 47/302 (15%)
Query: 210 DVAEKYLDIPKMLDAE---------DIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAAN 260
D+ E+ + K D+E D + R E+ I+ +SF A +G + E
Sbjct: 1858 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1917
Query: 261 RICK----VLAVNQENE-------QLMEDYEKLASDLLEWIRRTIPWLEN--RVPENTMH 307
RI L ++ E QL + E+ + E +++++ E R + +
Sbjct: 1918 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 1977
Query: 308 AMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRP---AFMPSEGRMVSDI 364
+++ + RRL + + + QL++ Q +L+ + A E + +
Sbjct: 1978 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2037
Query: 365 NNAWGCLEQV-----------EKGYEEWLLNE------IRRLERLDHLAEKFRQKASIHE 407
L+Q+ E+ E + E R++E + L + ++A
Sbjct: 2038 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2097
Query: 408 AWTDGKEAMLRQKDYETATLSEI-KALLKKHEAFESDLAAHQDRVEQI----AAIAQELN 462
E + ++ + E A ++ +A L++ +A ++++ H+ EQ A + QEL
Sbjct: 2098 QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2157
Query: 463 EL 464
L
Sbjct: 2158 TL 2159
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 242 bits (617), Expect = 1e-63
Identities = 147/396 (37%), Positives = 218/396 (55%), Gaps = 23/396 (5%)
Query: 30 EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHK 89
++ Q+KTFT W N HL KA I ++ ED RDG L+ LLEV+SG+ L + E+G+MR HK
Sbjct: 178 DRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFHK 236
Query: 90 ISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISV----EETS 145
+ NV ALD++ + VKLV+I ++I DGN K+TLG+IWTIIL F I DI V E+ +
Sbjct: 237 LQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMT 296
Query: 146 AKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNL 205
AKE LLLW QR Y+ + NF SW+DG F A+IHRH+P LID K+ + L NL
Sbjct: 297 AKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENL 356
Query: 206 NTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKV 265
+ AF VAE+ L + ++LD ED V +PDEK+I+TYVSS Y A +
Sbjct: 357 DQAFSVAERDLGVTRLLDPED-VDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRA---- 411
Query: 266 LAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKP 325
E + ++Y +L LL+W+R E R ++ ++ F ++ + P
Sbjct: 412 ----NELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELP 467
Query: 326 PKVQEKCQLEINFNTLQTKL---RLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWL 382
K +K + + + +L+ + +L P + P D+ WG L E+ L
Sbjct: 468 AKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHP------LDVEKEWGKLHVAILEREKQL 521
Query: 383 LNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLR 418
+E RLE L + K + +A + E + +A+L+
Sbjct: 522 RSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQ 557
Score = 34.3 bits (77), Expect = 0.53
Identities = 60/293 (20%), Positives = 117/293 (39%), Gaps = 27/293 (9%)
Query: 254 KAETAANRICKVLAVNQENEQLMEDYEKLASDLLE---WIRRTIPWLENRVPENTMHAMQ 310
KAE + K LA Q +L ED E++A L E +RT+ R E + A +
Sbjct: 2463 KAEAELLQQQKELAQEQAR-RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2521
Query: 311 QKL---EDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNA 367
KL E R R + + K EI +T+L + + +
Sbjct: 2522 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE--------- 2572
Query: 368 WGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASI-----HEAWTDGKEAMLRQKD- 421
+++ + ++ L E + L+ EK +Q+A + E T +E +L++
Sbjct: 2573 ---IQRQQSDHDAERLREA--IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2627
Query: 422 YETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICD 481
+ + LSE +LL++ E + A + + A AQ+L E + Q++
Sbjct: 2628 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2687
Query: 482 QWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQD 534
+ + E + R ++ L+ ++Q + + A N + ++ L++
Sbjct: 2688 SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE 2740
Score = 30.4 bits (67), Expect = 7.7
Identities = 56/302 (18%), Positives = 118/302 (39%), Gaps = 47/302 (15%)
Query: 210 DVAEKYLDIPKMLDAE---------DIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAAN 260
D+ E+ + K D+E D + R E+ I+ +SF A +G + E
Sbjct: 2027 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 2086
Query: 261 RICK----VLAVNQENE-------QLMEDYEKLASDLLEWIRRTIPWLEN--RVPENTMH 307
RI L ++ E QL + E+ + E +++++ E R + +
Sbjct: 2087 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2146
Query: 308 AMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRP---AFMPSEGRMVSDI 364
+++ + RRL + + + QL++ Q +L+ + A E + +
Sbjct: 2147 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2206
Query: 365 NNAWGCLEQV-----------EKGYEEWLLNE------IRRLERLDHLAEKFRQKASIHE 407
L+Q+ E+ E + E R++E + L + ++A
Sbjct: 2207 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2266
Query: 408 AWTDGKEAMLRQKDYETATLSEI-KALLKKHEAFESDLAAHQDRVEQI----AAIAQELN 462
E + ++ + E A ++ +A L++ +A ++++ H+ EQ A + QEL
Sbjct: 2267 QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2326
Query: 463 EL 464
L
Sbjct: 2327 TL 2328
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 242 bits (617), Expect = 1e-63
Identities = 147/396 (37%), Positives = 218/396 (55%), Gaps = 23/396 (5%)
Query: 30 EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHK 89
++ Q+KTFT W N HL KA I ++ ED RDG L+ LLEV+SG+ L + E+G+MR HK
Sbjct: 19 DRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFHK 77
Query: 90 ISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISV----EETS 145
+ NV ALD++ + VKLV+I ++I DGN K+TLG+IWTIIL F I DI V E+ +
Sbjct: 78 LQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMT 137
Query: 146 AKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNL 205
AKE LLLW QR Y+ + NF SW+DG F A+IHRH+P LID K+ + L NL
Sbjct: 138 AKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENL 197
Query: 206 NTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKV 265
+ AF VAE+ L + ++LD ED V +PDEK+I+TYVSS Y A +
Sbjct: 198 DQAFSVAERDLGVTRLLDPED-VDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRA---- 252
Query: 266 LAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKP 325
E + ++Y +L LL+W+R E R ++ ++ F ++ + P
Sbjct: 253 ----NELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELP 308
Query: 326 PKVQEKCQLEINFNTLQTKL---RLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWL 382
K +K + + + +L+ + +L P + P D+ WG L E+ L
Sbjct: 309 AKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHP------LDVEKEWGKLHVAILEREKQL 362
Query: 383 LNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLR 418
+E RLE L + K + +A + E + +A+L+
Sbjct: 363 RSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQ 398
Score = 34.3 bits (77), Expect = 0.53
Identities = 60/293 (20%), Positives = 117/293 (39%), Gaps = 27/293 (9%)
Query: 254 KAETAANRICKVLAVNQENEQLMEDYEKLASDLLE---WIRRTIPWLENRVPENTMHAMQ 310
KAE + K LA Q +L ED E++A L E +RT+ R E + A +
Sbjct: 2304 KAEAELLQQQKELAQEQAR-RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2362
Query: 311 QKL---EDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNA 367
KL E R R + + K EI +T+L + + +
Sbjct: 2363 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE--------- 2413
Query: 368 WGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASI-----HEAWTDGKEAMLRQKD- 421
+++ + ++ L E + L+ EK +Q+A + E T +E +L++
Sbjct: 2414 ---IQRQQSDHDAERLREA--IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2468
Query: 422 YETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICD 481
+ + LSE +LL++ E + A + + A AQ+L E + Q++
Sbjct: 2469 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2528
Query: 482 QWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQD 534
+ + E + R ++ L+ ++Q + + A N + ++ L++
Sbjct: 2529 SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE 2581
Score = 30.4 bits (67), Expect = 7.7
Identities = 56/302 (18%), Positives = 118/302 (39%), Gaps = 47/302 (15%)
Query: 210 DVAEKYLDIPKMLDAE---------DIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAAN 260
D+ E+ + K D+E D + R E+ I+ +SF A +G + E
Sbjct: 1868 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1927
Query: 261 RICK----VLAVNQENE-------QLMEDYEKLASDLLEWIRRTIPWLEN--RVPENTMH 307
RI L ++ E QL + E+ + E +++++ E R + +
Sbjct: 1928 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 1987
Query: 308 AMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRP---AFMPSEGRMVSDI 364
+++ + RRL + + + QL++ Q +L+ + A E + +
Sbjct: 1988 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2047
Query: 365 NNAWGCLEQV-----------EKGYEEWLLNE------IRRLERLDHLAEKFRQKASIHE 407
L+Q+ E+ E + E R++E + L + ++A
Sbjct: 2048 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2107
Query: 408 AWTDGKEAMLRQKDYETATLSEI-KALLKKHEAFESDLAAHQDRVEQI----AAIAQELN 462
E + ++ + E A ++ +A L++ +A ++++ H+ EQ A + QEL
Sbjct: 2108 QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2167
Query: 463 EL 464
L
Sbjct: 2168 TL 2169
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 242 bits (617), Expect = 1e-63
Identities = 147/396 (37%), Positives = 218/396 (55%), Gaps = 23/396 (5%)
Query: 30 EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHK 89
++ Q+KTFT W N HL KA I ++ ED RDG L+ LLEV+SG+ L + E+G+MR HK
Sbjct: 27 DRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFHK 85
Query: 90 ISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISV----EETS 145
+ NV ALD++ + VKLV+I ++I DGN K+TLG+IWTIIL F I DI V E+ +
Sbjct: 86 LQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMT 145
Query: 146 AKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNL 205
AKE LLLW QR Y+ + NF SW+DG F A+IHRH+P LID K+ + L NL
Sbjct: 146 AKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENL 205
Query: 206 NTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKV 265
+ AF VAE+ L + ++LD ED V +PDEK+I+TYVSS Y A +
Sbjct: 206 DQAFSVAERDLGVTRLLDPED-VDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRA---- 260
Query: 266 LAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKP 325
E + ++Y +L LL+W+R E R ++ ++ F ++ + P
Sbjct: 261 ----NELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELP 316
Query: 326 PKVQEKCQLEINFNTLQTKL---RLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWL 382
K +K + + + +L+ + +L P + P D+ WG L E+ L
Sbjct: 317 AKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHP------LDVEKEWGKLHVAILEREKQL 370
Query: 383 LNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLR 418
+E RLE L + K + +A + E + +A+L+
Sbjct: 371 RSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQ 406
Score = 34.3 bits (77), Expect = 0.53
Identities = 60/293 (20%), Positives = 117/293 (39%), Gaps = 27/293 (9%)
Query: 254 KAETAANRICKVLAVNQENEQLMEDYEKLASDLLE---WIRRTIPWLENRVPENTMHAMQ 310
KAE + K LA Q +L ED E++A L E +RT+ R E + A +
Sbjct: 2312 KAEAELLQQQKELAQEQAR-RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2370
Query: 311 QKL---EDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNA 367
KL E R R + + K EI +T+L + + +
Sbjct: 2371 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE--------- 2421
Query: 368 WGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASI-----HEAWTDGKEAMLRQKD- 421
+++ + ++ L E + L+ EK +Q+A + E T +E +L++
Sbjct: 2422 ---IQRQQSDHDAERLREA--IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2476
Query: 422 YETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICD 481
+ + LSE +LL++ E + A + + A AQ+L E + Q++
Sbjct: 2477 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2536
Query: 482 QWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQD 534
+ + E + R ++ L+ ++Q + + A N + ++ L++
Sbjct: 2537 SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE 2589
Score = 30.4 bits (67), Expect = 7.7
Identities = 56/302 (18%), Positives = 118/302 (39%), Gaps = 47/302 (15%)
Query: 210 DVAEKYLDIPKMLDAE---------DIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAAN 260
D+ E+ + K D+E D + R E+ I+ +SF A +G + E
Sbjct: 1876 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1935
Query: 261 RICK----VLAVNQENE-------QLMEDYEKLASDLLEWIRRTIPWLEN--RVPENTMH 307
RI L ++ E QL + E+ + E +++++ E R + +
Sbjct: 1936 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 1995
Query: 308 AMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRP---AFMPSEGRMVSDI 364
+++ + RRL + + + QL++ Q +L+ + A E + +
Sbjct: 1996 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2055
Query: 365 NNAWGCLEQV-----------EKGYEEWLLNE------IRRLERLDHLAEKFRQKASIHE 407
L+Q+ E+ E + E R++E + L + ++A
Sbjct: 2056 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2115
Query: 408 AWTDGKEAMLRQKDYETATLSEI-KALLKKHEAFESDLAAHQDRVEQI----AAIAQELN 462
E + ++ + E A ++ +A L++ +A ++++ H+ EQ A + QEL
Sbjct: 2116 QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2175
Query: 463 EL 464
L
Sbjct: 2176 TL 2177
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 242 bits (617), Expect = 1e-63
Identities = 147/396 (37%), Positives = 218/396 (55%), Gaps = 23/396 (5%)
Query: 30 EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHK 89
++ Q+KTFT W N HL KA I ++ ED RDG L+ LLEV+SG+ L + E+G+MR HK
Sbjct: 68 DRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFHK 126
Query: 90 ISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISV----EETS 145
+ NV ALD++ + VKLV+I ++I DGN K+TLG+IWTIIL F I DI V E+ +
Sbjct: 127 LQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMT 186
Query: 146 AKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNL 205
AKE LLLW QR Y+ + NF SW+DG F A+IHRH+P LID K+ + L NL
Sbjct: 187 AKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENL 246
Query: 206 NTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKV 265
+ AF VAE+ L + ++LD ED V +PDEK+I+TYVSS Y A +
Sbjct: 247 DQAFSVAERDLGVTRLLDPED-VDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRA---- 301
Query: 266 LAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKP 325
E + ++Y +L LL+W+R E R ++ ++ F ++ + P
Sbjct: 302 ----NELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELP 357
Query: 326 PKVQEKCQLEINFNTLQTKL---RLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWL 382
K +K + + + +L+ + +L P + P D+ WG L E+ L
Sbjct: 358 AKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHP------LDVEKEWGKLHVAILEREKQL 411
Query: 383 LNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLR 418
+E RLE L + K + +A + E + +A+L+
Sbjct: 412 RSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQ 447
Score = 34.3 bits (77), Expect = 0.53
Identities = 60/293 (20%), Positives = 117/293 (39%), Gaps = 27/293 (9%)
Query: 254 KAETAANRICKVLAVNQENEQLMEDYEKLASDLLE---WIRRTIPWLENRVPENTMHAMQ 310
KAE + K LA Q +L ED E++A L E +RT+ R E + A +
Sbjct: 2353 KAEAELLQQQKELAQEQAR-RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2411
Query: 311 QKL---EDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNA 367
KL E R R + + K EI +T+L + + +
Sbjct: 2412 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE--------- 2462
Query: 368 WGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASI-----HEAWTDGKEAMLRQKD- 421
+++ + ++ L E + L+ EK +Q+A + E T +E +L++
Sbjct: 2463 ---IQRQQSDHDAERLREA--IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2517
Query: 422 YETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICD 481
+ + LSE +LL++ E + A + + A AQ+L E + Q++
Sbjct: 2518 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2577
Query: 482 QWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQD 534
+ + E + R ++ L+ ++Q + + A N + ++ L++
Sbjct: 2578 SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE 2630
Score = 30.4 bits (67), Expect = 7.7
Identities = 56/302 (18%), Positives = 118/302 (39%), Gaps = 47/302 (15%)
Query: 210 DVAEKYLDIPKMLDAE---------DIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAAN 260
D+ E+ + K D+E D + R E+ I+ +SF A +G + E
Sbjct: 1917 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1976
Query: 261 RICK----VLAVNQENE-------QLMEDYEKLASDLLEWIRRTIPWLEN--RVPENTMH 307
RI L ++ E QL + E+ + E +++++ E R + +
Sbjct: 1977 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2036
Query: 308 AMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRP---AFMPSEGRMVSDI 364
+++ + RRL + + + QL++ Q +L+ + A E + +
Sbjct: 2037 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2096
Query: 365 NNAWGCLEQV-----------EKGYEEWLLNE------IRRLERLDHLAEKFRQKASIHE 407
L+Q+ E+ E + E R++E + L + ++A
Sbjct: 2097 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2156
Query: 408 AWTDGKEAMLRQKDYETATLSEI-KALLKKHEAFESDLAAHQDRVEQI----AAIAQELN 462
E + ++ + E A ++ +A L++ +A ++++ H+ EQ A + QEL
Sbjct: 2157 QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2216
Query: 463 EL 464
L
Sbjct: 2217 TL 2218
>gi|169218211 PREDICTED: similar to plectin 1, partial [Homo
sapiens]
Length = 1369
Score = 238 bits (607), Expect = 2e-62
Identities = 146/396 (36%), Positives = 216/396 (54%), Gaps = 23/396 (5%)
Query: 30 EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHK 89
++ Q+KT T W N HL KA I ++ ED RDG L+ LLEV+SG+ L + E+G+MR HK
Sbjct: 174 DRVQKKTSTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFHK 232
Query: 90 ISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISV----EETS 145
+ NV ALD++ + VKLV+I ++I DGN K+TLG+IWTIIL F I DI V E+ +
Sbjct: 233 LQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMT 292
Query: 146 AKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNL 205
AKE LLLW QR Y+ + NF SW+DG F A+IHRH+P LID K+ + L NL
Sbjct: 293 AKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENL 352
Query: 206 NTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKV 265
+ AF VAE+ L + ++LD ED V +PDEK+I+TYVSS Y A +
Sbjct: 353 DQAFSVAERDLGVTRLLDPED-VDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRA---- 407
Query: 266 LAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKP 325
E + ++Y +L LL+W+R E R ++ ++ F ++ + P
Sbjct: 408 ----NELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELP 463
Query: 326 PKVQEKCQLEINFNTLQTKL---RLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWL 382
K +K + + + +L+ + +L P + P D+ WG L E+ L
Sbjct: 464 AKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHP------LDVEKEWGKLHVAILEREKQL 517
Query: 383 LNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLR 418
+E RLE L + K + +A + E +A+L+
Sbjct: 518 RSEFERLECLQRIVTKLQMEAGLCEEQLHQADALLQ 553
>gi|221316624 dystonin isoform 4 [Homo sapiens]
Length = 5526
Score = 236 bits (603), Expect = 5e-62
Identities = 141/382 (36%), Positives = 211/382 (55%), Gaps = 18/382 (4%)
Query: 30 EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHK 89
+K Q+KTFT W N HL K + ++ ED RDG L+ LLEV+SG+ L + E+G+MR H+
Sbjct: 63 DKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPR-EKGRMRFHR 121
Query: 90 ISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISV----EETS 145
+ NV ALD++ + VKLV+I ++I DGN K+TLG+IWTIIL F I DI V E+ S
Sbjct: 122 LQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESEDMS 181
Query: 146 AKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNL 205
AKE LLLW Q+ T Y + +NF W+DG F A+IH++RP+LID + L NL
Sbjct: 182 AKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANL 241
Query: 206 NTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKV 265
AF VAEK + + ++LD ED V + PDEK+++TYVSS Y AF +
Sbjct: 242 EHAFYVAEK-IGVIRLLDPED-VDVSSPDEKSVITYVSSLYDAFPKVPEGGEG------- 292
Query: 266 LAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKP 325
+ N + +E Y+ + + L++WIR + + R N ++ + ++ P
Sbjct: 293 IGANDVEVKWIE-YQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIP 351
Query: 326 PKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNE 385
PK EK +++ + L+ + +G +DI WG L E+ L E
Sbjct: 352 PKETEKSKIKRLYKLLEIWIEFGRIKLL---QGYHPNDIEKEWGKLIIAMLEREKALRPE 408
Query: 386 IRRLERLDHLAEKFRQKASIHE 407
+ RLE L +A + ++ + I E
Sbjct: 409 VERLEMLQQIANRVQRDSVICE 430
Score = 62.8 bits (151), Expect = 1e-09
Identities = 102/488 (20%), Positives = 191/488 (39%), Gaps = 71/488 (14%)
Query: 197 RKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAE 256
++ + + D ++ LDI L +E I PD+ + + A+ KA
Sbjct: 4139 QQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAW 4198
Query: 257 TAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENT-MHAMQQKLED 315
+RI K+ +E Q Y+ + +W+ L + P T + ++Q++E+
Sbjct: 4199 K--DRIDKL----EEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEE 4252
Query: 316 FRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVE 375
+ ++ E Q +I L + L + S+ V D L+ +
Sbjct: 4253 LKQFK--------SEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLME---LKLIW 4301
Query: 376 KGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLK 435
EE ++N +LE +F+ AW E +L ++ I+ L
Sbjct: 4302 DSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELA 4361
Query: 436 KHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRRE 495
KH ++D+ AHQ VE + +L E ++ ++ + + L L Q+ +
Sbjct: 4362 KHHVLQNDVLAHQSTVEAVNKAGNDLIE---------SSAGEEASNLQNKLEVLNQRWQN 4412
Query: 496 ALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFK 555
LE+TE+ + +D L AK G +EDLQ Q LT
Sbjct: 4413 VLEKTEQRKQQLDGA-LRQAK-------GFHGEIEDLQ-----------QWLTDTERHLL 4453
Query: 556 AT-----LPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQL 610
A+ LP+ KE+ L +H EV + A Y ++ + +Q+
Sbjct: 4454 ASKPLGGLPETAKEQ---LNVHMEVCAAFE------AKEETYKSLMQKG--------QQM 4496
Query: 611 VPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSH 670
+ R ++ E + Q N K + + +TK+EE +++E H +L+D ++
Sbjct: 4497 LARCPKS-AETNIDQDINNLKEKWESVETKLNER--KTKLEEALNLAMEFHNSLQDFINW 4553
Query: 671 LRQYEKSI 678
L Q E+++
Sbjct: 4554 LTQAEQTL 4561
Score = 48.9 bits (115), Expect = 2e-05
Identities = 77/405 (19%), Positives = 170/405 (41%), Gaps = 45/405 (11%)
Query: 376 KGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLK 435
K E+ N ++ L+ + +F+Q + +AW D K+ + +A L +++L+K
Sbjct: 2771 KDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIK 2830
Query: 436 KHEAFESDLAAHQDRVEQIAAIAQE-LNELDYYDSPSVNARCQKICDQWDNLGALTQKRR 494
H+ F L A E+ A + L + + ++ + I WD +
Sbjct: 2831 DHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTF------NK 2884
Query: 495 EALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQF 554
+ ER KL E++++ L+Y ++ W++ +L++ I ++ +G E
Sbjct: 2885 QVKERENKLKESLEKA-LKYKEQVETLWPWIDKCQNNLEE--IKFCLDPAEG-----ENS 2936
Query: 555 KATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGK--WDHVRQLVP 612
A L KE G+ V + + ++ EI+ + D + L+
Sbjct: 2937 IAKLKSLQKEMDQHFGM------------VELLNNTANSLLSVCEIDKEVVTDENKSLIQ 2984
Query: 613 RRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQ----- 667
+ D + H+++ E + ++F V + + + +++H +L Q
Sbjct: 2985 KVDMVTEQLHSKKFCLENMTQKFKEFQEVSKE--SKRQLQCAKEQLDIHDSLGSQAYSNK 3042
Query: 668 -LSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALI--FDNKHTNYTMEHIRVGWEQLLTTI 724
L+ L+ +KS+ K ++D + +L Q+ ++ D+K T+ + + Q +T+
Sbjct: 3043 YLTMLQTQQKSLQALKHQVDLAK---RLAQDLVVEASDSKGTSDVLLQVET-IAQEHSTL 3098
Query: 725 ARTINEVENQILTR-DAKGISQEQMNEFRASFNHFDRDHSGTLGP 768
++ ++E + + T+ G Q + E + F FD D ++ P
Sbjct: 3099 SQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFD-DELDSMAP 3142
Score = 33.9 bits (76), Expect = 0.69
Identities = 70/328 (21%), Positives = 123/328 (37%), Gaps = 33/328 (10%)
Query: 371 LEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHE---AWTDGKEAMLRQKDYETATL 427
LE ++ Y++ + L+ + R+ S HE W D E L YET
Sbjct: 3636 LEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLS--YETQ-- 3691
Query: 428 SEIKALLKKHEAFESDLAAHQDRVE--QIAAIAQELNELDYYDSPSVNARCQKICDQWDN 485
+LK EA ++ + + + E A+ LNE+ +A + + W
Sbjct: 3692 -----VLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVS-------SALLELV--PWRA 3737
Query: 486 LGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQ 545
L + E ER + +TI Q E AA + D + ++I T +++
Sbjct: 3738 REGLEKMVAEDNERYRLVSDTITQKVEEID--AAILRSQQFDQAADAELSWITETEKKLM 3795
Query: 546 GL---TTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEING 602
L +Q A L + IL + + +V++ H M + Q +
Sbjct: 3796 SLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEK---QSMKK 3852
Query: 603 KWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEM-- 660
K D V + Q +E + + + + L QF + PW+ I ++
Sbjct: 3853 KLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALE 3912
Query: 661 HGTLEDQLSHLRQYEKSIVNYKPKIDQL 688
+ TL Q RQ + I +KP ID++
Sbjct: 3913 YETLRQQQEEHRQLRELIAEHKPHIDKM 3940
Score = 33.5 bits (75), Expect = 0.90
Identities = 23/89 (25%), Positives = 40/89 (44%), Gaps = 4/89 (4%)
Query: 380 EWLLNEI----RRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLK 435
E LLN+ R+LE + +A++F + W E L + S+++ +
Sbjct: 3426 EALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIA 3485
Query: 436 KHEAFESDLAAHQDRVEQIAAIAQELNEL 464
+H+A E D+ H + Q +I Q L L
Sbjct: 3486 QHKALEDDIINHNKHLHQAVSIGQSLKVL 3514
Score = 33.5 bits (75), Expect = 0.90
Identities = 37/165 (22%), Positives = 64/165 (38%), Gaps = 39/165 (23%)
Query: 408 AWTDGKEAMLRQKDYETAT--LSEIKALLKKHEAFESDLAAHQDRVEQI----------- 454
AW E L KD E + E+KAL+ +H+ F ++ Q V+++
Sbjct: 4988 AWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADP 5047
Query: 455 AAIAQELNELD-------------YYDSPS------VNARCQKICDQWDNLGALTQKRR- 494
+++ + LD Y S S N R + +W + L +RR
Sbjct: 5048 SSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRR 5107
Query: 495 ---EALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTF 536
+AL+R E+L E + + + K+ + WM + D F
Sbjct: 5108 KLNDALDRLEELREFANFDFDIWRKK---YMRWMNHKKSRVMDFF 5149
Score = 32.3 bits (72), Expect = 2.0
Identities = 18/63 (28%), Positives = 33/63 (52%), Gaps = 6/63 (9%)
Query: 649 KMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKP------KIDQLEGDHQLIQEALIFD 702
++E I ++ + H TLE L EK +VN +P K+++ H+ +++ +I
Sbjct: 3438 QLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINH 3497
Query: 703 NKH 705
NKH
Sbjct: 3498 NKH 3500
>gi|221316622 dystonin isoform 3 [Homo sapiens]
Length = 5537
Score = 236 bits (603), Expect = 5e-62
Identities = 141/382 (36%), Positives = 211/382 (55%), Gaps = 18/382 (4%)
Query: 30 EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHK 89
+K Q+KTFT W N HL K + ++ ED RDG L+ LLEV+SG+ L + E+G+MR H+
Sbjct: 74 DKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPR-EKGRMRFHR 132
Query: 90 ISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISV----EETS 145
+ NV ALD++ + VKLV+I ++I DGN K+TLG+IWTIIL F I DI V E+ S
Sbjct: 133 LQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESEDMS 192
Query: 146 AKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNL 205
AKE LLLW Q+ T Y + +NF W+DG F A+IH++RP+LID + L NL
Sbjct: 193 AKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANL 252
Query: 206 NTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKV 265
AF VAEK + + ++LD ED V + PDEK+++TYVSS Y AF +
Sbjct: 253 EHAFYVAEK-IGVIRLLDPED-VDVSSPDEKSVITYVSSLYDAFPKVPEGGEG------- 303
Query: 266 LAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKP 325
+ N + +E Y+ + + L++WIR + + R N ++ + ++ P
Sbjct: 304 IGANDVEVKWIE-YQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIP 362
Query: 326 PKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNE 385
PK EK +++ + L+ + +G +DI WG L E+ L E
Sbjct: 363 PKETEKSKIKRLYKLLEIWIEFGRIKLL---QGYHPNDIEKEWGKLIIAMLEREKALRPE 419
Query: 386 IRRLERLDHLAEKFRQKASIHE 407
+ RLE L +A + ++ + I E
Sbjct: 420 VERLEMLQQIANRVQRDSVICE 441
Score = 62.8 bits (151), Expect = 1e-09
Identities = 102/488 (20%), Positives = 191/488 (39%), Gaps = 71/488 (14%)
Query: 197 RKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAE 256
++ + + D ++ LDI L +E I PD+ + + A+ KA
Sbjct: 4150 QQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAW 4209
Query: 257 TAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENT-MHAMQQKLED 315
+RI K+ +E Q Y+ + +W+ L + P T + ++Q++E+
Sbjct: 4210 K--DRIDKL----EEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEE 4263
Query: 316 FRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVE 375
+ ++ E Q +I L + L + S+ V D L+ +
Sbjct: 4264 LKQFK--------SEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLME---LKLIW 4312
Query: 376 KGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLK 435
EE ++N +LE +F+ AW E +L ++ I+ L
Sbjct: 4313 DSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELA 4372
Query: 436 KHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRRE 495
KH ++D+ AHQ VE + +L E ++ ++ + + L L Q+ +
Sbjct: 4373 KHHVLQNDVLAHQSTVEAVNKAGNDLIE---------SSAGEEASNLQNKLEVLNQRWQN 4423
Query: 496 ALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFK 555
LE+TE+ + +D L AK G +EDLQ Q LT
Sbjct: 4424 VLEKTEQRKQQLDGA-LRQAK-------GFHGEIEDLQ-----------QWLTDTERHLL 4464
Query: 556 AT-----LPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQL 610
A+ LP+ KE+ L +H EV + A Y ++ + +Q+
Sbjct: 4465 ASKPLGGLPETAKEQ---LNVHMEVCAAFE------AKEETYKSLMQKG--------QQM 4507
Query: 611 VPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSH 670
+ R ++ E + Q N K + + +TK+EE +++E H +L+D ++
Sbjct: 4508 LARCPKS-AETNIDQDINNLKEKWESVETKLNER--KTKLEEALNLAMEFHNSLQDFINW 4564
Query: 671 LRQYEKSI 678
L Q E+++
Sbjct: 4565 LTQAEQTL 4572
Score = 48.9 bits (115), Expect = 2e-05
Identities = 77/405 (19%), Positives = 170/405 (41%), Gaps = 45/405 (11%)
Query: 376 KGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLK 435
K E+ N ++ L+ + +F+Q + +AW D K+ + +A L +++L+K
Sbjct: 2782 KDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIK 2841
Query: 436 KHEAFESDLAAHQDRVEQIAAIAQE-LNELDYYDSPSVNARCQKICDQWDNLGALTQKRR 494
H+ F L A E+ A + L + + ++ + I WD +
Sbjct: 2842 DHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTF------NK 2895
Query: 495 EALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQF 554
+ ER KL E++++ L+Y ++ W++ +L++ I ++ +G E
Sbjct: 2896 QVKERENKLKESLEKA-LKYKEQVETLWPWIDKCQNNLEE--IKFCLDPAEG-----ENS 2947
Query: 555 KATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGK--WDHVRQLVP 612
A L KE G+ V + + ++ EI+ + D + L+
Sbjct: 2948 IAKLKSLQKEMDQHFGM------------VELLNNTANSLLSVCEIDKEVVTDENKSLIQ 2995
Query: 613 RRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQ----- 667
+ D + H+++ E + ++F V + + + +++H +L Q
Sbjct: 2996 KVDMVTEQLHSKKFCLENMTQKFKEFQEVSKE--SKRQLQCAKEQLDIHDSLGSQAYSNK 3053
Query: 668 -LSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALI--FDNKHTNYTMEHIRVGWEQLLTTI 724
L+ L+ +KS+ K ++D + +L Q+ ++ D+K T+ + + Q +T+
Sbjct: 3054 YLTMLQTQQKSLQALKHQVDLAK---RLAQDLVVEASDSKGTSDVLLQVET-IAQEHSTL 3109
Query: 725 ARTINEVENQILTR-DAKGISQEQMNEFRASFNHFDRDHSGTLGP 768
++ ++E + + T+ G Q + E + F FD D ++ P
Sbjct: 3110 SQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFD-DELDSMAP 3153
Score = 33.9 bits (76), Expect = 0.69
Identities = 70/328 (21%), Positives = 123/328 (37%), Gaps = 33/328 (10%)
Query: 371 LEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHE---AWTDGKEAMLRQKDYETATL 427
LE ++ Y++ + L+ + R+ S HE W D E L YET
Sbjct: 3647 LEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLS--YETQ-- 3702
Query: 428 SEIKALLKKHEAFESDLAAHQDRVE--QIAAIAQELNELDYYDSPSVNARCQKICDQWDN 485
+LK EA ++ + + + E A+ LNE+ +A + + W
Sbjct: 3703 -----VLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVS-------SALLELV--PWRA 3748
Query: 486 LGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQ 545
L + E ER + +TI Q E AA + D + ++I T +++
Sbjct: 3749 REGLEKMVAEDNERYRLVSDTITQKVEEID--AAILRSQQFDQAADAELSWITETEKKLM 3806
Query: 546 GL---TTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEING 602
L +Q A L + IL + + +V++ H M + Q +
Sbjct: 3807 SLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEK---QSMKK 3863
Query: 603 KWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEM-- 660
K D V + Q +E + + + + L QF + PW+ I ++
Sbjct: 3864 KLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALE 3923
Query: 661 HGTLEDQLSHLRQYEKSIVNYKPKIDQL 688
+ TL Q RQ + I +KP ID++
Sbjct: 3924 YETLRQQQEEHRQLRELIAEHKPHIDKM 3951
Score = 33.5 bits (75), Expect = 0.90
Identities = 23/89 (25%), Positives = 40/89 (44%), Gaps = 4/89 (4%)
Query: 380 EWLLNEI----RRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLK 435
E LLN+ R+LE + +A++F + W E L + S+++ +
Sbjct: 3437 EALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIA 3496
Query: 436 KHEAFESDLAAHQDRVEQIAAIAQELNEL 464
+H+A E D+ H + Q +I Q L L
Sbjct: 3497 QHKALEDDIINHNKHLHQAVSIGQSLKVL 3525
Score = 33.5 bits (75), Expect = 0.90
Identities = 37/165 (22%), Positives = 64/165 (38%), Gaps = 39/165 (23%)
Query: 408 AWTDGKEAMLRQKDYETAT--LSEIKALLKKHEAFESDLAAHQDRVEQI----------- 454
AW E L KD E + E+KAL+ +H+ F ++ Q V+++
Sbjct: 4999 AWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADP 5058
Query: 455 AAIAQELNELD-------------YYDSPS------VNARCQKICDQWDNLGALTQKRR- 494
+++ + LD Y S S N R + +W + L +RR
Sbjct: 5059 SSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRR 5118
Query: 495 ---EALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTF 536
+AL+R E+L E + + + K+ + WM + D F
Sbjct: 5119 KLNDALDRLEELREFANFDFDIWRKK---YMRWMNHKKSRVMDFF 5160
Score = 32.3 bits (72), Expect = 2.0
Identities = 18/63 (28%), Positives = 33/63 (52%), Gaps = 6/63 (9%)
Query: 649 KMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKP------KIDQLEGDHQLIQEALIFD 702
++E I ++ + H TLE L EK +VN +P K+++ H+ +++ +I
Sbjct: 3449 QLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINH 3508
Query: 703 NKH 705
NKH
Sbjct: 3509 NKH 3511
>gi|221316618 dystonin isoform 2 [Homo sapiens]
Length = 5675
Score = 236 bits (603), Expect = 5e-62
Identities = 141/382 (36%), Positives = 211/382 (55%), Gaps = 18/382 (4%)
Query: 30 EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHK 89
+K Q+KTFT W N HL K + ++ ED RDG L+ LLEV+SG+ L + E+G+MR H+
Sbjct: 212 DKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPR-EKGRMRFHR 270
Query: 90 ISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISV----EETS 145
+ NV ALD++ + VKLV+I ++I DGN K+TLG+IWTIIL F I DI V E+ S
Sbjct: 271 LQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESEDMS 330
Query: 146 AKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNL 205
AKE LLLW Q+ T Y + +NF W+DG F A+IH++RP+LID + L NL
Sbjct: 331 AKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANL 390
Query: 206 NTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKV 265
AF VAEK + + ++LD ED V + PDEK+++TYVSS Y AF +
Sbjct: 391 EHAFYVAEK-IGVIRLLDPED-VDVSSPDEKSVITYVSSLYDAFPKVPEGGEG------- 441
Query: 266 LAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKP 325
+ N + +E Y+ + + L++WIR + + R N ++ + ++ P
Sbjct: 442 IGANDVEVKWIE-YQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIP 500
Query: 326 PKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNE 385
PK EK +++ + L+ + +G +DI WG L E+ L E
Sbjct: 501 PKETEKSKIKRLYKLLEIWIEFGRIKLL---QGYHPNDIEKEWGKLIIAMLEREKALRPE 557
Query: 386 IRRLERLDHLAEKFRQKASIHE 407
+ RLE L +A + ++ + I E
Sbjct: 558 VERLEMLQQIANRVQRDSVICE 579
Score = 62.8 bits (151), Expect = 1e-09
Identities = 102/488 (20%), Positives = 191/488 (39%), Gaps = 71/488 (14%)
Query: 197 RKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAE 256
++ + + D ++ LDI L +E I PD+ + + A+ KA
Sbjct: 4288 QQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAW 4347
Query: 257 TAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENT-MHAMQQKLED 315
+RI K+ +E Q Y+ + +W+ L + P T + ++Q++E+
Sbjct: 4348 K--DRIDKL----EEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEE 4401
Query: 316 FRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVE 375
+ ++ E Q +I L + L + S+ V D L+ +
Sbjct: 4402 LKQFK--------SEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLME---LKLIW 4450
Query: 376 KGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLK 435
EE ++N +LE +F+ AW E +L ++ I+ L
Sbjct: 4451 DSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELA 4510
Query: 436 KHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRRE 495
KH ++D+ AHQ VE + +L E ++ ++ + + L L Q+ +
Sbjct: 4511 KHHVLQNDVLAHQSTVEAVNKAGNDLIE---------SSAGEEASNLQNKLEVLNQRWQN 4561
Query: 496 ALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFK 555
LE+TE+ + +D L AK G +EDLQ Q LT
Sbjct: 4562 VLEKTEQRKQQLDGA-LRQAK-------GFHGEIEDLQ-----------QWLTDTERHLL 4602
Query: 556 AT-----LPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQL 610
A+ LP+ KE+ L +H EV + A Y ++ + +Q+
Sbjct: 4603 ASKPLGGLPETAKEQ---LNVHMEVCAAFE------AKEETYKSLMQKG--------QQM 4645
Query: 611 VPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSH 670
+ R ++ E + Q N K + + +TK+EE +++E H +L+D ++
Sbjct: 4646 LARCPKS-AETNIDQDINNLKEKWESVETKLNER--KTKLEEALNLAMEFHNSLQDFINW 4702
Query: 671 LRQYEKSI 678
L Q E+++
Sbjct: 4703 LTQAEQTL 4710
Score = 48.9 bits (115), Expect = 2e-05
Identities = 77/405 (19%), Positives = 170/405 (41%), Gaps = 45/405 (11%)
Query: 376 KGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLK 435
K E+ N ++ L+ + +F+Q + +AW D K+ + +A L +++L+K
Sbjct: 2920 KDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIK 2979
Query: 436 KHEAFESDLAAHQDRVEQIAAIAQE-LNELDYYDSPSVNARCQKICDQWDNLGALTQKRR 494
H+ F L A E+ A + L + + ++ + I WD +
Sbjct: 2980 DHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTF------NK 3033
Query: 495 EALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQF 554
+ ER KL E++++ L+Y ++ W++ +L++ I ++ +G E
Sbjct: 3034 QVKERENKLKESLEKA-LKYKEQVETLWPWIDKCQNNLEE--IKFCLDPAEG-----ENS 3085
Query: 555 KATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGK--WDHVRQLVP 612
A L KE G+ V + + ++ EI+ + D + L+
Sbjct: 3086 IAKLKSLQKEMDQHFGM------------VELLNNTANSLLSVCEIDKEVVTDENKSLIQ 3133
Query: 613 RRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQ----- 667
+ D + H+++ E + ++F V + + + +++H +L Q
Sbjct: 3134 KVDMVTEQLHSKKFCLENMTQKFKEFQEVSKE--SKRQLQCAKEQLDIHDSLGSQAYSNK 3191
Query: 668 -LSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALI--FDNKHTNYTMEHIRVGWEQLLTTI 724
L+ L+ +KS+ K ++D + +L Q+ ++ D+K T+ + + Q +T+
Sbjct: 3192 YLTMLQTQQKSLQALKHQVDLAK---RLAQDLVVEASDSKGTSDVLLQVET-IAQEHSTL 3247
Query: 725 ARTINEVENQILTR-DAKGISQEQMNEFRASFNHFDRDHSGTLGP 768
++ ++E + + T+ G Q + E + F FD D ++ P
Sbjct: 3248 SQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFD-DELDSMAP 3291
Score = 33.9 bits (76), Expect = 0.69
Identities = 70/328 (21%), Positives = 123/328 (37%), Gaps = 33/328 (10%)
Query: 371 LEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHE---AWTDGKEAMLRQKDYETATL 427
LE ++ Y++ + L+ + R+ S HE W D E L YET
Sbjct: 3785 LEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLS--YETQ-- 3840
Query: 428 SEIKALLKKHEAFESDLAAHQDRVE--QIAAIAQELNELDYYDSPSVNARCQKICDQWDN 485
+LK EA ++ + + + E A+ LNE+ +A + + W
Sbjct: 3841 -----VLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVS-------SALLELV--PWRA 3886
Query: 486 LGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQ 545
L + E ER + +TI Q E AA + D + ++I T +++
Sbjct: 3887 REGLEKMVAEDNERYRLVSDTITQKVEEID--AAILRSQQFDQAADAELSWITETEKKLM 3944
Query: 546 GL---TTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEING 602
L +Q A L + IL + + +V++ H M + Q +
Sbjct: 3945 SLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEK---QSMKK 4001
Query: 603 KWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEM-- 660
K D V + Q +E + + + + L QF + PW+ I ++
Sbjct: 4002 KLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALE 4061
Query: 661 HGTLEDQLSHLRQYEKSIVNYKPKIDQL 688
+ TL Q RQ + I +KP ID++
Sbjct: 4062 YETLRQQQEEHRQLRELIAEHKPHIDKM 4089
Score = 33.5 bits (75), Expect = 0.90
Identities = 23/89 (25%), Positives = 40/89 (44%), Gaps = 4/89 (4%)
Query: 380 EWLLNEI----RRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLK 435
E LLN+ R+LE + +A++F + W E L + S+++ +
Sbjct: 3575 EALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIA 3634
Query: 436 KHEAFESDLAAHQDRVEQIAAIAQELNEL 464
+H+A E D+ H + Q +I Q L L
Sbjct: 3635 QHKALEDDIINHNKHLHQAVSIGQSLKVL 3663
Score = 33.5 bits (75), Expect = 0.90
Identities = 37/165 (22%), Positives = 64/165 (38%), Gaps = 39/165 (23%)
Query: 408 AWTDGKEAMLRQKDYETAT--LSEIKALLKKHEAFESDLAAHQDRVEQI----------- 454
AW E L KD E + E+KAL+ +H+ F ++ Q V+++
Sbjct: 5137 AWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADP 5196
Query: 455 AAIAQELNELD-------------YYDSPS------VNARCQKICDQWDNLGALTQKRR- 494
+++ + LD Y S S N R + +W + L +RR
Sbjct: 5197 SSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRR 5256
Query: 495 ---EALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTF 536
+AL+R E+L E + + + K+ + WM + D F
Sbjct: 5257 KLNDALDRLEELREFANFDFDIWRKK---YMRWMNHKKSRVMDFF 5298
Score = 32.3 bits (72), Expect = 2.0
Identities = 18/63 (28%), Positives = 33/63 (52%), Gaps = 6/63 (9%)
Query: 649 KMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKP------KIDQLEGDHQLIQEALIFD 702
++E I ++ + H TLE L EK +VN +P K+++ H+ +++ +I
Sbjct: 3587 QLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINH 3646
Query: 703 NKH 705
NKH
Sbjct: 3647 NKH 3649
>gi|34577047 dystonin isoform 1 [Homo sapiens]
Length = 5497
Score = 236 bits (603), Expect = 5e-62
Identities = 141/382 (36%), Positives = 211/382 (55%), Gaps = 18/382 (4%)
Query: 30 EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHK 89
+K Q+KTFT W N HL K + ++ ED RDG L+ LLEV+SG+ L + E+G+MR H+
Sbjct: 34 DKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPR-EKGRMRFHR 92
Query: 90 ISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISV----EETS 145
+ NV ALD++ + VKLV+I ++I DGN K+TLG+IWTIIL F I DI V E+ S
Sbjct: 93 LQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESEDMS 152
Query: 146 AKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNL 205
AKE LLLW Q+ T Y + +NF W+DG F A+IH++RP+LID + L NL
Sbjct: 153 AKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANL 212
Query: 206 NTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKV 265
AF VAEK + + ++LD ED V + PDEK+++TYVSS Y AF +
Sbjct: 213 EHAFYVAEK-IGVIRLLDPED-VDVSSPDEKSVITYVSSLYDAFPKVPEGGEG------- 263
Query: 266 LAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKP 325
+ N + +E Y+ + + L++WIR + + R N ++ + ++ P
Sbjct: 264 IGANDVEVKWIE-YQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIP 322
Query: 326 PKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNE 385
PK EK +++ + L+ + +G +DI WG L E+ L E
Sbjct: 323 PKETEKSKIKRLYKLLEIWIEFGRIKLL---QGYHPNDIEKEWGKLIIAMLEREKALRPE 379
Query: 386 IRRLERLDHLAEKFRQKASIHE 407
+ RLE L +A + ++ + I E
Sbjct: 380 VERLEMLQQIANRVQRDSVICE 401
Score = 62.8 bits (151), Expect = 1e-09
Identities = 102/488 (20%), Positives = 191/488 (39%), Gaps = 71/488 (14%)
Query: 197 RKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAE 256
++ + + D ++ LDI L +E I PD+ + + A+ KA
Sbjct: 4110 QQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAW 4169
Query: 257 TAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENT-MHAMQQKLED 315
+RI K+ +E Q Y+ + +W+ L + P T + ++Q++E+
Sbjct: 4170 K--DRIDKL----EEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEE 4223
Query: 316 FRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVE 375
+ ++ E Q +I L + L + S+ V D L+ +
Sbjct: 4224 LKQFK--------SEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLME---LKLIW 4272
Query: 376 KGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLK 435
EE ++N +LE +F+ AW E +L ++ I+ L
Sbjct: 4273 DSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELA 4332
Query: 436 KHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRRE 495
KH ++D+ AHQ VE + +L E ++ ++ + + L L Q+ +
Sbjct: 4333 KHHVLQNDVLAHQSTVEAVNKAGNDLIE---------SSAGEEASNLQNKLEVLNQRWQN 4383
Query: 496 ALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFK 555
LE+TE+ + +D L AK G +EDLQ Q LT
Sbjct: 4384 VLEKTEQRKQQLDGA-LRQAK-------GFHGEIEDLQ-----------QWLTDTERHLL 4424
Query: 556 AT-----LPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQL 610
A+ LP+ KE+ L +H EV + A Y ++ + +Q+
Sbjct: 4425 ASKPLGGLPETAKEQ---LNVHMEVCAAFE------AKEETYKSLMQKG--------QQM 4467
Query: 611 VPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSH 670
+ R ++ E + Q N K + + +TK+EE +++E H +L+D ++
Sbjct: 4468 LARCPKS-AETNIDQDINNLKEKWESVETKLNER--KTKLEEALNLAMEFHNSLQDFINW 4524
Query: 671 LRQYEKSI 678
L Q E+++
Sbjct: 4525 LTQAEQTL 4532
Score = 48.9 bits (115), Expect = 2e-05
Identities = 77/405 (19%), Positives = 170/405 (41%), Gaps = 45/405 (11%)
Query: 376 KGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLK 435
K E+ N ++ L+ + +F+Q + +AW D K+ + +A L +++L+K
Sbjct: 2742 KDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIK 2801
Query: 436 KHEAFESDLAAHQDRVEQIAAIAQE-LNELDYYDSPSVNARCQKICDQWDNLGALTQKRR 494
H+ F L A E+ A + L + + ++ + I WD +
Sbjct: 2802 DHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTF------NK 2855
Query: 495 EALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQF 554
+ ER KL E++++ L+Y ++ W++ +L++ I ++ +G E
Sbjct: 2856 QVKERENKLKESLEKA-LKYKEQVETLWPWIDKCQNNLEE--IKFCLDPAEG-----ENS 2907
Query: 555 KATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGK--WDHVRQLVP 612
A L KE G+ V + + ++ EI+ + D + L+
Sbjct: 2908 IAKLKSLQKEMDQHFGM------------VELLNNTANSLLSVCEIDKEVVTDENKSLIQ 2955
Query: 613 RRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQ----- 667
+ D + H+++ E + ++F V + + + +++H +L Q
Sbjct: 2956 KVDMVTEQLHSKKFCLENMTQKFKEFQEVSKE--SKRQLQCAKEQLDIHDSLGSQAYSNK 3013
Query: 668 -LSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALI--FDNKHTNYTMEHIRVGWEQLLTTI 724
L+ L+ +KS+ K ++D + +L Q+ ++ D+K T+ + + Q +T+
Sbjct: 3014 YLTMLQTQQKSLQALKHQVDLAK---RLAQDLVVEASDSKGTSDVLLQVET-IAQEHSTL 3069
Query: 725 ARTINEVENQILTR-DAKGISQEQMNEFRASFNHFDRDHSGTLGP 768
++ ++E + + T+ G Q + E + F FD D ++ P
Sbjct: 3070 SQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFD-DELDSMAP 3113
Score = 33.9 bits (76), Expect = 0.69
Identities = 70/328 (21%), Positives = 123/328 (37%), Gaps = 33/328 (10%)
Query: 371 LEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHE---AWTDGKEAMLRQKDYETATL 427
LE ++ Y++ + L+ + R+ S HE W D E L YET
Sbjct: 3607 LEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLS--YETQ-- 3662
Query: 428 SEIKALLKKHEAFESDLAAHQDRVE--QIAAIAQELNELDYYDSPSVNARCQKICDQWDN 485
+LK EA ++ + + + E A+ LNE+ +A + + W
Sbjct: 3663 -----VLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVS-------SALLELV--PWRA 3708
Query: 486 LGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQ 545
L + E ER + +TI Q E AA + D + ++I T +++
Sbjct: 3709 REGLEKMVAEDNERYRLVSDTITQKVEEID--AAILRSQQFDQAADAELSWITETEKKLM 3766
Query: 546 GL---TTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEING 602
L +Q A L + IL + + +V++ H M + Q +
Sbjct: 3767 SLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEK---QSMKK 3823
Query: 603 KWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEM-- 660
K D V + Q +E + + + + L QF + PW+ I ++
Sbjct: 3824 KLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALE 3883
Query: 661 HGTLEDQLSHLRQYEKSIVNYKPKIDQL 688
+ TL Q RQ + I +KP ID++
Sbjct: 3884 YETLRQQQEEHRQLRELIAEHKPHIDKM 3911
Score = 33.5 bits (75), Expect = 0.90
Identities = 23/89 (25%), Positives = 40/89 (44%), Gaps = 4/89 (4%)
Query: 380 EWLLNEI----RRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLK 435
E LLN+ R+LE + +A++F + W E L + S+++ +
Sbjct: 3397 EALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIA 3456
Query: 436 KHEAFESDLAAHQDRVEQIAAIAQELNEL 464
+H+A E D+ H + Q +I Q L L
Sbjct: 3457 QHKALEDDIINHNKHLHQAVSIGQSLKVL 3485
Score = 33.5 bits (75), Expect = 0.90
Identities = 37/165 (22%), Positives = 64/165 (38%), Gaps = 39/165 (23%)
Query: 408 AWTDGKEAMLRQKDYETAT--LSEIKALLKKHEAFESDLAAHQDRVEQI----------- 454
AW E L KD E + E+KAL+ +H+ F ++ Q V+++
Sbjct: 4959 AWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADP 5018
Query: 455 AAIAQELNELD-------------YYDSPS------VNARCQKICDQWDNLGALTQKRR- 494
+++ + LD Y S S N R + +W + L +RR
Sbjct: 5019 SSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRR 5078
Query: 495 ---EALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTF 536
+AL+R E+L E + + + K+ + WM + D F
Sbjct: 5079 KLNDALDRLEELREFANFDFDIWRKK---YMRWMNHKKSRVMDFF 5120
Score = 32.3 bits (72), Expect = 2.0
Identities = 18/63 (28%), Positives = 33/63 (52%), Gaps = 6/63 (9%)
Query: 649 KMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKP------KIDQLEGDHQLIQEALIFD 702
++E I ++ + H TLE L EK +VN +P K+++ H+ +++ +I
Sbjct: 3409 QLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINH 3468
Query: 703 NKH 705
NKH
Sbjct: 3469 NKH 3471
>gi|33188445 microfilament and actin filament cross-linker protein
isoform a [Homo sapiens]
Length = 5430
Score = 226 bits (577), Expect = 6e-59
Identities = 158/483 (32%), Positives = 251/483 (51%), Gaps = 46/483 (9%)
Query: 21 RDLLLDPAW----------EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLE 70
+D +LDPA ++ Q+KTFT W N HL K I ++ ED RDG L+ LLE
Sbjct: 58 QDSVLDPAERAVVRVADERDRVQKKTFTKWVNKHLMKVRKHINDLYEDLRDGHNLISLLE 117
Query: 71 VISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTI 130
V+SG +L + E+G+MR H++ NV ALDF+ + VKLV+I ++I DGN K+TLG+IWTI
Sbjct: 118 VLSGIKLPR-EKGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTI 176
Query: 131 ILRFAIQDISVE----ETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRH 186
IL F I DI + + SAKE LLLW Q+ TA Y + NF W DG F ALIHR+
Sbjct: 177 ILHFQISDIYISGESGDMSAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIHRY 236
Query: 187 RPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFY 246
RP+L+D +++ NL AF+VAE+ L + ++LDAED V PDEK+++TYVSS Y
Sbjct: 237 RPDLVDMERVQIQSNRENLEQAFEVAER-LGVTRLLDAED-VDVPSPDEKSVITYVSSIY 294
Query: 247 HAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRR-TIPWLENRVPENT 305
AF + + E + ++Y+ L+ WI++ TI + P+N
Sbjct: 295 DAFPKVPEGGEGISA--------TEVDSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNP 346
Query: 306 MHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDIN 365
+ ++ + ++ K +EK ++E + L+ + +G +D+
Sbjct: 347 VE-LKALYNQYIHFKETEILAKEREKGRIEELYKLLEVWIEFGR---IKLPQGYHPNDVE 402
Query: 366 NAWG--CLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYE 423
WG +E +E+ E+ L + RLE L +A K + A + +E + K+
Sbjct: 403 EEWGKLIIEMLER--EKSLRPAVERLELLLQIANKIQNGA------LNCEEKLTLAKNTL 454
Query: 424 TATLSEIKALLKKHEAFESDLAAH----QDRVEQIAAIAQELNELDYYDSPSVNARCQKI 479
A + +++ + ESD+ + + + Q+ Q L + +YY + R ++
Sbjct: 455 QADAAHLES--GQPVQCESDVIMYIQECEGLIRQLQVDLQILRDENYYQLEELAFRVMRL 512
Query: 480 CDQ 482
D+
Sbjct: 513 QDE 515
Score = 50.1 bits (118), Expect = 9e-06
Identities = 98/511 (19%), Positives = 202/511 (39%), Gaps = 64/511 (12%)
Query: 279 YEKLASDLLEWIRRTIPWLENRVPENTM-HAMQQKLEDFRDYRRLHKPPKVQEKCQLEIN 337
Y++L DL E +R L + +T A++Q+LE+ + R + QL+
Sbjct: 2626 YQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIR--------SDLEQLDHE 2677
Query: 338 FNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAE 397
QT L + + + E + ++ + +G E+ + I RL+ +
Sbjct: 2678 VKEAQT---LCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQ 2734
Query: 398 KFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAI 457
+F+Q W D K++ + +A L +++ L+++E F+ L H E I A
Sbjct: 2735 QFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAE 2794
Query: 458 AQE--LNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYA 515
+ L+ + ++ + ++ + W+ L T R+ L+ + Q Y +
Sbjct: 2795 GESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKA----QKYQWHV 2850
Query: 516 KRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEV 575
+ P W+E + + + T++ +Q L ++ + KA L + +K R ++L I N
Sbjct: 2851 EDLVP---WIEDCKAKMSELRV--TLDPVQ-LESSLLRSKAMLNEVEKRR-SLLEILNSA 2903
Query: 576 SKIV--------QTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQ------ALTEE 621
+ I+ AG N +E+ K + ++ R + + ++
Sbjct: 2904 ADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKK 2963
Query: 622 HARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNY 681
+H + G+QA K E R E+ LE Q+ +LR + + +V
Sbjct: 2964 VEGAKHQLEIFDALGSQA------CSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVED 3017
Query: 682 KP---------------KIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIAR 726
P + + LE ++ ++ +NK H RV ++ + +A
Sbjct: 3018 APDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRV--REMFSQLAD 3075
Query: 727 TINEVENQ-ILTRDAKGISQEQMNEFRASFN 756
+E++ + RD + Q Q+ + R N
Sbjct: 3076 LDDELDGMGAIGRDTDSL-QSQIEDVRLFLN 3105
Score = 45.1 bits (105), Expect = 3e-04
Identities = 54/298 (18%), Positives = 122/298 (40%), Gaps = 29/298 (9%)
Query: 210 DVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVN 269
D + L+ ++L A+ I ++ + + +A+ K T R+ K+
Sbjct: 4097 DGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNK--TWKERLEKL---- 4150
Query: 270 QENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENT-MHAMQQKLEDFRD-----YRRLH 323
++ Q Y+ + +W+ T+ L P T ++ ++ +L + ++ Y++
Sbjct: 4151 EDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQI 4210
Query: 324 KPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLL 383
+ K+ + +L + T +T + P ++++ + W L + + L
Sbjct: 4211 EMEKLNHQGELMLKKATDETDRDIIREP---------LTELKHLWENLGEKIAHRQHKLE 4261
Query: 384 NEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESD 443
+ L + H E+ +W E +L + + I+ L KH ++D
Sbjct: 4262 GALLALGQFQHALEELM-------SWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKND 4314
Query: 444 LAAHQDRVEQIAAIAQELNELDY-YDSPSVNARCQKICDQWDNLGALTQKRREALERT 500
+ AHQ VE + EL E D+ S+ +R + + W+++ T++R + L+ T
Sbjct: 4315 VLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQST 4372
Score = 43.9 bits (102), Expect = 7e-04
Identities = 100/558 (17%), Positives = 214/558 (38%), Gaps = 79/558 (14%)
Query: 226 DIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASD 285
+I GT ++K ++ +K E+ + + +N E +E + L +
Sbjct: 3779 EIFGTCGEEQKTVLQ------------EKTESLIQQYEAISLLNSERYARLERAQVLVNQ 3826
Query: 286 LLEWIRRTIPWLEN-----------RVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQL 334
E PW+E + + Q+++ R+ HK P + + ++
Sbjct: 3827 FWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHK-PHIDKLLKI 3885
Query: 335 EINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIR-RLERLD 393
L P EG MV + ++ E Y + + E+R R LD
Sbjct: 3886 GPQLKELN------------PEEGEMVEE------KYQKAENMYAQ-IKEEVRQRALALD 3926
Query: 394 HLAEKFRQKASIHE------AWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAH 447
+ Q H+ + + LR A + +I+ + +++ +L
Sbjct: 3927 EAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKL 3986
Query: 448 QDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQK-RREALERTEKLLET 506
Q E + +EL + + ++I D+ D + + + A ER K L+
Sbjct: 3987 QPSFEALKRRGEEL--IGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDV 4044
Query: 507 IDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERL 566
++ + AA + ++D QD IVH +E G+ + + + + KE
Sbjct: 4045 LELAEKFWYDMAA-----LLTTIKDTQD--IVHDLES-PGIDPSIIKQQVEAAETIKEET 4096
Query: 567 AILGIHNEVS--KIVQTYHVNMAG--TNPYTTITPQEINGKWDHVRQLVPRRDQALTEE- 621
G+H E+ +I+ + G P + E+N W+++ + R + L +
Sbjct: 4097 D--GLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAM 4154
Query: 622 HARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNY 681
A Q+ + L+ F N + K+ + + +++ T++DQL+ +++++ +
Sbjct: 4155 QAAVQYQDTLQAMFDWLDNTV-----IKLCTMPPVGTDLN-TVKDQLNEMKEFKVEVYQQ 4208
Query: 682 KPKIDQL--EGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRD 739
+ ++++L +G+ L + D + ++ WE L IA +++E +L
Sbjct: 4209 QIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALL--- 4265
Query: 740 AKGISQEQMNEFRASFNH 757
A G Q + E + H
Sbjct: 4266 ALGQFQHALEELMSWLTH 4283
Score = 43.9 bits (102), Expect = 7e-04
Identities = 78/405 (19%), Positives = 146/405 (36%), Gaps = 64/405 (15%)
Query: 264 KVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLH 323
KV+ + E + ++D K A E ++ I WLE+ + +LE D ++
Sbjct: 4576 KVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESH-----LDSELEISNDPDKIK 4630
Query: 324 KPPKVQEKCQLEIN-----FNTLQTKLRLSNRPAFMPSEGR----MVSDINNAWG--CLE 372
++ Q + ++T R +P + + + ++ + W C +
Sbjct: 4631 LQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGK 4690
Query: 373 QVEKGY--EEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEI 430
VE+ + EE LL + ++ L L + W E L + L +
Sbjct: 4691 SVERQHKLEEALLFSGQFMDALQALVD-----------WLYKVEPQLAEDQPVHGDLDLV 4739
Query: 431 KALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALT 490
L+ H+ F+ +L V+ + +EL E D+ V + Q++ +WD + L+
Sbjct: 4740 MNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLS 4799
Query: 491 QKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTA 550
++ LE+ K E +DT VH + E
Sbjct: 4800 VSKQSRLEQALKQAEVF-------------------------RDT--VHMLLEWLSEAEQ 4832
Query: 551 HEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNM-----AGTNPYTTITPQEINGKWD 605
+F+ LPD + +++ H E K V+ V++ G P I
Sbjct: 4833 TLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKH 4892
Query: 606 HVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIG---PWIQ 647
+ + R ++ LT QQ E + A A ++ WIQ
Sbjct: 4893 WITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQ 4937
Score = 39.3 bits (90), Expect = 0.016
Identities = 54/248 (21%), Positives = 99/248 (39%), Gaps = 20/248 (8%)
Query: 303 ENTMHAMQQKLEDFRDYRRLHKPPKVQEKC-QLEINFNTLQTKLRLSNRPA---FMPSEG 358
++ + + L D + KPP + K + +I L +L L +R A + +EG
Sbjct: 3283 QDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRL-LDDRKATVDMLQAEG 3341
Query: 359 RMVS------DINNAWGCLEQVEKGYEEWLLNEIRRLERLDH---LAEKFRQKASIHEAW 409
++ D G LE +E + E L R ++L+ LA++F + A +
Sbjct: 3342 GRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDF 3401
Query: 410 TDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDS 469
E L + ++I+ + +H+A E D+ H V Q I Q L+ L S
Sbjct: 3402 LSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSL---TS 3458
Query: 470 PSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAM 529
P A + ++ D+L A + ++ R LL+ + + NW+
Sbjct: 3459 P---AEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVE 3515
Query: 530 EDLQDTFI 537
+ L F+
Sbjct: 3516 DKLSSVFV 3523
Score = 38.9 bits (89), Expect = 0.022
Identities = 65/326 (19%), Positives = 130/326 (39%), Gaps = 61/326 (18%)
Query: 253 QKAETAANRICKVLAVNQEN-EQLMEDYEKLASD---LLEWIRRTIPWLENR--VPENTM 306
Q+ T + +CK+ Q EQ ++ E LLEW+ L R +P++T
Sbjct: 4786 QELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDT- 4844
Query: 307 HAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINN 366
A+Q ++ +++ + KV+EK ++++N ++ L+ ++ I +
Sbjct: 4845 EALQSLIDTHKEFMK-----KVEEK-RVDVNSAVAMGEVILA------VCHPDCITTIKH 4892
Query: 367 AWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHE---AWTDGKEAMLRQKDYE 423
W + + +EE L + +RL+ + A + E AW E L Q+D E
Sbjct: 4893 -W--ITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQE 4949
Query: 424 TA--TLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYY-------------- 467
+ +KAL+ +H+ F ++ Q V+++ + N +
Sbjct: 4950 PIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKS 5009
Query: 468 -------------DSPSVNARCQKICDQWDNLGALTQKRR----EALERTEKLLETIDQL 510
S + N R ++ +W + L +R+ +AL+R E+L E +
Sbjct: 5010 LSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELKEFANFD 5069
Query: 511 YLEYAKRAAPFNNWMEGAMEDLQDTF 536
+ + K+ + WM + D F
Sbjct: 5070 FDVWRKK---YMRWMNHKKSRVMDFF 5092
Score = 37.7 bits (86), Expect = 0.048
Identities = 36/181 (19%), Positives = 75/181 (41%), Gaps = 19/181 (10%)
Query: 482 QWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTI 541
+++ LG + +R+E+L+ +E E K A W+E E L+ + +
Sbjct: 2378 KYEKLGGVLHERQESLQAILNRME-------EVHKEANSVLQWLESKEEVLKSMDAMSSP 2430
Query: 542 EEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEIN 601
+ + + E KA L + ++ I + ++ ++ TY + N +E+N
Sbjct: 2431 TKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAEN--WKKIQEELN 2488
Query: 602 GKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTK---MEEIGRISI 658
+W+ ++ R + L E + F A + + PW+ K M +G +SI
Sbjct: 2489 SRWERATEVTVARQRQLEESASH-------LACFQAAESQLRPWLMEKELMMGVLGPLSI 2541
Query: 659 E 659
+
Sbjct: 2542 D 2542
Score = 37.0 bits (84), Expect = 0.082
Identities = 65/330 (19%), Positives = 127/330 (38%), Gaps = 38/330 (11%)
Query: 371 LEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWT------DGKEAMLRQKDYET 424
L V+ +E+ + I R LD ++ +Q HEAW + E+ L + +
Sbjct: 4567 LVSVQSRWEKVVQRSIERGRSLDDARKRAKQ---FHEAWKKLIDWLEDAESHLDSELEIS 4623
Query: 425 ATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNE--LDYYDSPSVNARCQKICDQ 482
+IK L KH+ F+ L Q + + L E L DS ++ ++ D+
Sbjct: 4624 NDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDK 4683
Query: 483 WDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVH-TI 541
WD + + +R+ LE E LL ++ +W+ L + VH +
Sbjct: 4684 WDTVCGKSVERQHKLE--EALL-----FSGQFMDALQALVDWLYKVEPQLAEDQPVHGDL 4736
Query: 542 EEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEIN 601
+ + L AH+ F+ L K + + ++++ N + QE++
Sbjct: 4737 DLVMNLMDAHKVFQKEL---GKRTGTVQVLKRSGRELIE----NSRDDTTWVKGQLQELS 4789
Query: 602 GKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMH 661
+WD V +L + L E A +Q + F +++ W+ + ++
Sbjct: 4790 TRWDTVCKLSVSKQSRL--EQALKQ-----AEVFRDTVHMLLEWLSEAEQ-----TLRFR 4837
Query: 662 GTLEDQLSHLRQYEKSIVNYKPKIDQLEGD 691
G L D L+ + + K+++ D
Sbjct: 4838 GALPDDTEALQSLIDTHKEFMKKVEEKRVD 4867
Score = 35.4 bits (80), Expect = 0.24
Identities = 43/253 (16%), Positives = 97/253 (38%), Gaps = 16/253 (6%)
Query: 264 KVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLH 323
K L ++ QL ++ +L W+R E +++ F+ ++
Sbjct: 3594 KALRTLEQARQLATKFQSTYEELTGWLREVE---EELATSGGQSPTGEQIPQFQQRQKEL 3650
Query: 324 KPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEG--RMVSDINNAWGCLEQVEKGYEEW 381
K ++ + L+ + L L + EG ++VSD N + K +
Sbjct: 3651 KKEVMEHRLVLDTVNEVSRALLELV---PWRAREGLDKLVSDANEQY-------KLVSDT 3700
Query: 382 LLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFE 441
+ + ++ ++++ Q A AW + L + A L+ +AF
Sbjct: 3701 IGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFS 3760
Query: 442 SDLAAHQDRVEQIAAIAQELNELDYYDSPSV-NARCQKICDQWDNLGALTQKRREALERT 500
D+ H+D ++++ + E+ + +V + + + Q++ + L +R LER
Sbjct: 3761 IDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERA 3820
Query: 501 EKLLETIDQLYLE 513
+ L+ + Y E
Sbjct: 3821 QVLVNQFWETYEE 3833
Score = 34.3 bits (77), Expect = 0.53
Identities = 38/229 (16%), Positives = 91/229 (39%), Gaps = 13/229 (5%)
Query: 248 AFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMH 307
A + A + ET ++ K LA N++ + D+ + +P +E +
Sbjct: 1660 AVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEK 1719
Query: 308 AMQQKLEDFRDYRRLHKPPKVQEKCQL------EINFNTLQTKLRLSNRPAFMPSEGRMV 361
+ + + P K+ ++C++ E+ L + AF+ G +
Sbjct: 1720 GALDTTDGYMGVNQA--PEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNL 1777
Query: 362 SDINNAW--GCLEQVEKGYEEWLLN---EIRRLERLDHLAEKFRQKASIHEAWTDGKEAM 416
+ L ++++ Y L E+++++ L +KF Q E+W + E
Sbjct: 1778 TPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKE 1837
Query: 417 LRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELD 465
L ++ + +LLK+ +F D+ +H+ + + Q++ +++
Sbjct: 1838 LENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDME 1886
Score = 33.5 bits (75), Expect = 0.90
Identities = 98/521 (18%), Positives = 200/521 (38%), Gaps = 70/521 (13%)
Query: 210 DVAEKYLDIPKML----DAEDIVGTARPDEKAIMTYVSSFYHAFSG-----AQKAETAAN 260
++AE + + K+ D +I G PD + + S F A+++
Sbjct: 1983 ELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQK 2042
Query: 261 RICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYR 320
I + +V + E L++ ++ +L + + L + V + + + +D
Sbjct: 2043 AIAQSQSVQESLESLLQSIGEVEQNLEG---KQVSSLSSGVIQEALATNMKLKQDI---- 2095
Query: 321 RLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWG--CLEQVEKGY 378
++K LE + + ++ +G++ ++++ + CL+Q EK
Sbjct: 2096 -------ARQKSSLEATREMVTRFMETADSTTAAVLQGKL-AEVSQRFEQLCLQQQEK-- 2145
Query: 379 EEWLLNEIRRLERLDHLAEKFRQ---------------KASIHEAWTDGKEAMLRQKDYE 423
E L + + E +HL+ K +Q I + +E L +D +
Sbjct: 2146 ESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQ 2205
Query: 424 TATLSEIKALLKKHEA--FESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICD 481
L ++ L+ + + F DL HQDRV+ + EL + + + CQ+ D
Sbjct: 2206 E-NLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQK-TVKEREKDASSCQEQLD 2263
Query: 482 QWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHT- 540
++ L QK + E + ET + A +E L D T
Sbjct: 2264 EFRKLVRTFQKWLKETEGSIPPTET--------SMSAKELEKQIEHLKSLLDDWASKGTL 2315
Query: 541 IEEIQGLTTAHEQ--FKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQ 598
+EEI T+ E + T PD+ + +IL V YH T ++
Sbjct: 2316 VEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMS-- 2373
Query: 599 EINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISI 658
++N K++ + ++ R ++L A E + K +AN + W+++K E + +
Sbjct: 2374 DVNLKYEKLGGVLHERQESL---QAILNRMEEVHK----EANSVLQWLESKEEVLKSMDA 2426
Query: 659 EMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEAL 699
T + + + K+ + +++Q Q ++EAL
Sbjct: 2427 MSSPTKTETVKAQAESNKA---FLAELEQNSPKIQKVKEAL 2464
>gi|115298659 spectrin, alpha, erythrocytic 1 [Homo sapiens]
Length = 2419
Score = 219 bits (558), Expect = 9e-57
Identities = 136/503 (27%), Positives = 254/503 (50%), Gaps = 18/503 (3%)
Query: 393 DHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAA-HQDRV 451
D+ ++F KA + EAW KE L+ A L + LL K + ++ L + Q+R+
Sbjct: 1927 DYAFQEFNWKADVVEAWIADKETSLKTNG-NGADLGDFLTLLAKQDTLDASLQSFQQERL 1985
Query: 452 EQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLY 511
+I + +L + S ++ R + +W+ L + R+ L + L+ + L+
Sbjct: 1986 PEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLF 2045
Query: 512 LEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGI 571
+E+A +A+ NNW E E+L + ++ EI+ L HE F A+L A + +L +
Sbjct: 2046 VEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLLEL 2105
Query: 572 HNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERL 631
++ + ++PYT +T + + W H+ ++ R+Q L +E ARQ N +
Sbjct: 2106 DQQIKAL-------GVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEM 2158
Query: 632 RKQFGAQANVIGPWI-QTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEG 690
++F A+ WI +T+ + ++ GTLE QL ++ +K I K ++ ++
Sbjct: 2159 CQEFEQNASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVD 2218
Query: 691 DHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNE 750
+++ALI D K Y+ + W+QL R + +E QI +D KG+S+E + E
Sbjct: 2219 LGDNLEDALILDIK---YSTIGLAQQWDQLYQLGLRMQHNLEQQIQAKDIKGVSEETLKE 2275
Query: 751 FRASFNHFDRDHSGTLGPEEFKACLISLGY--DIGNDPQGEAEFARIMSIVDPNRLGVVT 808
F + HFD + +G L +EF++CL L Y + + + E +F + + VDP R G V+
Sbjct: 2276 FSTIYKHFDENLTGRLTHKEFRSCLRGLNYYLPMVEEDEHEPKFEKFLDAVDPGRKGYVS 2335
Query: 809 FQAFIDFM-SRETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMAPY 867
+ + F+ +E+ + ++D++ +F+ LA K+YIT +++++ L P+Q +C M Y
Sbjct: 2336 LEDYTAFLIDKESENIKSSDEIENAFQALAEGKSYITKEDMKQALTPEQVSFCATHMQQY 2395
Query: 868 TGP--DSVPGALDYMSFSTALYG 888
P S DY+ F+ + +G
Sbjct: 2396 MDPRGRSHLSGYDYVGFTNSYFG 2418
Score = 68.2 bits (165), Expect = 3e-11
Identities = 97/489 (19%), Positives = 193/489 (39%), Gaps = 84/489 (17%)
Query: 253 QKAETAANRICKVL-AVNQENEQLMEDYEKL-----ASDLLEWIRRTIPWLENRVPENT- 305
Q+ E N+ +L + +L++ Y + A D+LEWI + + ENT
Sbjct: 1055 QRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWI-------QEKKAENTG 1107
Query: 306 -----MHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPA-------- 352
+ +Q+K ++F+ + NT + +LR N+ A
Sbjct: 1108 VELDDVWELQKKFDEFQK------------------DLNTNEPRLRDINKVADDLLFEGL 1149
Query: 353 FMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDG 412
P ++ ++N+ WG L++ L +E R+L H E F ++A + +
Sbjct: 1150 LTPEGAQIRQELNSRWGSLQR--------LADEQRQLLGSAHAVEVFHREADDTKEQIEK 1201
Query: 413 KEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSV 472
K L D + L ++AL ++HE FE DL D+V + A+ L+E + +
Sbjct: 1202 KCQALSAAD-PGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDL 1260
Query: 473 NARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDL 532
+ ++ + W++L T+ R+E+L +K YL + +A NW+ +
Sbjct: 1261 QRQKMELNEAWEDLQGRTKDRKESLNEAQK-------FYL-FLSKARDLQNWISSIGGMV 1312
Query: 533 QDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPY 592
+ + I+ L H++ +A D + E + + ++++ + H +P
Sbjct: 1313 SSQELAEDLTGIEILLERHQEHRA---DMEAEAPTFQALEDFSAELIDSGH----HASPE 1365
Query: 593 TTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEE 652
Q + + D + + +R + L + Q F + + W+ +
Sbjct: 1366 IEKKLQAVKLERDDLEKAWEKRKKILDQCLELQ--------MFQGNCDQVESWMVARENS 1417
Query: 653 IGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEH 712
+ +LE + +K+I + KI LE E+LI D +Y E
Sbjct: 1418 LRSDDKSSLDSLEALMKKRDDLDKAITAQEGKITDLEH----FAESLIADE---HYAKEE 1470
Query: 713 IRVGWEQLL 721
I +++L
Sbjct: 1471 IATRLQRVL 1479
Score = 57.0 bits (136), Expect = 8e-08
Identities = 54/234 (23%), Positives = 95/234 (40%), Gaps = 35/234 (14%)
Query: 277 EDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLE- 335
+ Y + +D+LEWI A+ +E D+ R K E Q+E
Sbjct: 161 QQYVQECADILEWI-------------GDKEAIATSVELGEDWERTEVLHKKFEDFQVEL 207
Query: 336 -------INFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRR 388
+ N + N P +P +++N AW L + ++R
Sbjct: 208 VAKEGRVVEVNQYANECAEENHPD-LPLIQSKQNEVNAAWERLRGLA----------LQR 256
Query: 389 LERLDHLAEKFRQKASIHEA--WTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAA 446
+ L + A R K + EA W KE +L +DY ++ + L H+ E +LA
Sbjct: 257 QKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVAS-EGLFHSHKGLERNLAV 315
Query: 447 HQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERT 500
D+V+++ A A++L D+P + + + W+++ AL R E L+ T
Sbjct: 316 MSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQAT 369
Score = 54.7 bits (130), Expect = 4e-07
Identities = 32/140 (22%), Positives = 66/140 (47%), Gaps = 10/140 (7%)
Query: 387 RRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAA 446
RRL + L +K + + + W + K+ + +DY+ + +K+ ++K + FE +LA
Sbjct: 575 RRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDYKD--IQNLKSRVQKQQVFEKELAV 632
Query: 447 HQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLET 506
++ ++E I QE+ E +Y S +V R ++ W+ L T+++ L +
Sbjct: 633 NKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQ---- 688
Query: 507 IDQLYLEYAKRAAPFNNWME 526
L++ A W+E
Sbjct: 689 ----QLQFENNAEDLQRWLE 704
Score = 52.8 bits (125), Expect = 1e-06
Identities = 46/186 (24%), Positives = 85/186 (45%), Gaps = 6/186 (3%)
Query: 314 EDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQ 373
ED++D + L + Q+ + E+ N Q + + M G SD N L +
Sbjct: 608 EDYKDIQNLKSRVQKQQVFEKELAVNKTQLE-NIQKTGQEMIEGGHYASD--NVTTRLSE 664
Query: 374 VEKGYEEWLLNEIRRLERLDHLAEK--FRQKASIHEAWTDGKEAMLRQKDYETATLSEIK 431
V +EE L ++ +L ++ F A + W + E + +DY L+E++
Sbjct: 665 VASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKG-LAEVQ 723
Query: 432 ALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQ 491
L+KH ES +AA QD+V+ + +A E+ + DS + AR + + +++ L
Sbjct: 724 NRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLA 783
Query: 492 KRREAL 497
R++ L
Sbjct: 784 TRKKKL 789
Score = 52.0 bits (123), Expect = 2e-06
Identities = 60/277 (21%), Positives = 112/277 (40%), Gaps = 42/277 (15%)
Query: 407 EAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDY 466
++W +EA L +D + L +ALL+KHE FE A ++++ + A +L D+
Sbjct: 489 DSWMSRQEAFLENEDLGNS-LGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDH 547
Query: 467 YDSPSVNARCQKICDQWDNLGALTQKRREALERT---EKLLETIDQLYLEYAKRAAPFNN 523
YDS ++ A + + D L RR L+ + +KL E D L N
Sbjct: 548 YDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDL-----------KN 596
Query: 524 WMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYH 583
W+ + D ++IQ L + ++ + + + + I ++++ H
Sbjct: 597 WINKKKKLADD----EDYKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGH 652
Query: 584 VNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIG 643
A N T ++ E+ W+ + + T++ Q H + QF A +
Sbjct: 653 --YASDNVTTRLS--EVASLWEELLE--------ATKQKGTQLHEANQQLQFENNAEDLQ 700
Query: 644 PWI-----QTKMEEIGRISIEM------HGTLEDQLS 669
W+ Q E+ G+ E+ HG LE ++
Sbjct: 701 RWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVA 737
Score = 52.0 bits (123), Expect = 2e-06
Identities = 51/254 (20%), Positives = 104/254 (40%), Gaps = 25/254 (9%)
Query: 398 KFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAI 457
+F Q E+W + K + +DY L ++ LLKKH+ E +L AH+ ++ + +
Sbjct: 1717 QFFQDLDDEESWIEEKLIRVSSQDYGR-DLQGVQNLLKKHKRLEGELVAHEPAIQNVLDM 1775
Query: 458 AQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKR 517
A++L + + R + + W+ L L + R LE + + YL++ +
Sbjct: 1776 AEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLE--------YLQFMQN 1827
Query: 518 AAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFK--ATLPDADKERLAILGIHNEV 575
A W+ T+ Q L HE + + + + + G + +
Sbjct: 1828 AEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQG-EDIL 1886
Query: 576 SKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQF 635
+K++Q N +EI+ K + + + P +A+ Q ++ ++F
Sbjct: 1887 NKVLQEESQN------------KEISSKIEALNEKTPSLAKAIA-AWKLQLEDDYAFQEF 1933
Query: 636 GAQANVIGPWIQTK 649
+A+V+ WI K
Sbjct: 1934 NWKADVVEAWIADK 1947
Score = 48.1 bits (113), Expect = 4e-05
Identities = 47/265 (17%), Positives = 109/265 (41%), Gaps = 29/265 (10%)
Query: 372 EQVEKGYEEWLLNEIRRLERLDHLAE--KFRQKASIHEAWTDGKEAMLRQKDYETATLSE 429
+ +EK +E +R + LD E F+ E+W +E LR D ++L
Sbjct: 1378 DDLEKAWE-------KRKKILDQCLELQMFQGNCDQVESWMVARENSLRSDD--KSSLDS 1428
Query: 430 IKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGAL 489
++AL+KK + + + A + ++ + A+ L ++Y + R Q++ D+W L A
Sbjct: 1429 LEALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKA- 1487
Query: 490 TQKRREALERTEKL--LETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGL 547
+ ++ KL + Q Y + + +E + ++ T + ++ +
Sbjct: 1488 -----QLIDERTKLGDYANLKQFYRDLEE--------LEEWISEMLPTACDESYKDATNI 1534
Query: 548 TTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHV 607
+ + + + D + G+ N + +++ + G +++ WDH+
Sbjct: 1535 QRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACD--GNEEAMKEQLEQLKEHWDHL 1592
Query: 608 RQLVPRRDQALTEEHARQQHNERLR 632
+ + + L E +Q+ N +R
Sbjct: 1593 LERTNDKGKKLNEASRQQRFNTSIR 1617
Score = 46.6 bits (109), Expect = 1e-04
Identities = 83/460 (18%), Positives = 173/460 (37%), Gaps = 56/460 (12%)
Query: 271 ENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQE 330
E+ ++ +++ A DL +WI + L ++ E+ + +Q K + + +VQ
Sbjct: 50 EDSYHLQVFKRDADDLGKWIMEKVNILTDKSYEDPTN-IQGKYQKHQSLEA-----EVQT 103
Query: 331 KCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLE 390
K +L + + A ++ + ++ + W L ++ + LL ++ +
Sbjct: 104 KSRLMSELEKTREERFTMGHSAHEETKAH-IEELRHLWDLLLELTLEKGDQLLRALKFQQ 162
Query: 391 RLDHLAEKFRQKASIHEAWTDGKEAMLRQ----KDYETATLSEIKALLKKHEAFESDLAA 446
+ A+ W KEA+ +D+E + L KK E F+ +L A
Sbjct: 163 YVQECADILE--------WIGDKEAIATSVELGEDWERT-----EVLHKKFEDFQVELVA 209
Query: 447 HQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLET 506
+ RV ++ A E E ++ D P + ++ ++ W+ L L +R++AL L
Sbjct: 210 KEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKALSNAANL--- 266
Query: 507 IDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAH---EQFKATLPDADK 563
+ + W++ L + +GL +H E+ A + D K
Sbjct: 267 -----QRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVK 321
Query: 564 ERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHA 623
E A + K+ ++ P +++ W+H+R L R + L +
Sbjct: 322 ELCA------KAEKLTLSH----PSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATY- 370
Query: 624 RQQHNERLRKQFGAQANVIGPWIQTKMEEIG--RISIEMHGTLEDQLSHLRQYEKSIVNY 681
+F + + + W+ K I + ++ G E L +Q++ I +Y
Sbjct: 371 -------WYHRFSSDFDELSGWMNEKTAAINADELPTDVAGG-EVLLDRHQQHKHEIDSY 422
Query: 682 KPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLL 721
+ + Q + A + ME + W LL
Sbjct: 423 DDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALL 462
Score = 46.6 bits (109), Expect = 1e-04
Identities = 38/190 (20%), Positives = 82/190 (43%), Gaps = 11/190 (5%)
Query: 371 LEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIH--EAWTDGKEAMLRQKDYETATLS 428
LEQ+++ ++ L + ++L+ + + R SI E W E +L KD + L+
Sbjct: 1582 LEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKD-QARDLA 1640
Query: 429 EIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGA 488
LLKKH+ E ++ A +D ++ + +A++L ++ + + + ++ N+
Sbjct: 1641 SAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNVQE 1700
Query: 489 LTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLT 548
L E L+ L + L E +W+E + + ++ +Q L
Sbjct: 1701 LAAAHHEKLKEAYALFQFFQDLDDE--------ESWIEEKLIRVSSQDYGRDLQGVQNLL 1752
Query: 549 TAHEQFKATL 558
H++ + L
Sbjct: 1753 KKHKRLEGEL 1762
Score = 45.4 bits (106), Expect = 2e-04
Identities = 78/455 (17%), Positives = 178/455 (39%), Gaps = 48/455 (10%)
Query: 272 NEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRR--LHKPPKVQ 329
N ++ +++ ++ ++WI+ P L + + A + + R KV+
Sbjct: 262 NAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVK 321
Query: 330 EKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRL 389
E C KL LS+ P+ P M D+ ++W + + E L
Sbjct: 322 ELC-------AKAEKLTLSH-PSDAPQIQEMKEDLVSSWEHIRALATSRYEKL------- 366
Query: 390 ERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQD 449
+ + +F W + K A + + T + LL +H+ + ++ ++ D
Sbjct: 367 -QATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGG-EVLLDRHQQHKHEIDSYDD 424
Query: 450 RVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQ 509
R + Q+L ++ S V + + + + W L L +R E + +D
Sbjct: 425 RFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYE------QCLD- 477
Query: 510 LYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAIL 569
+L Y + + ++WM L++ + +++ + L HE F+ +++ I+
Sbjct: 478 FHLFY-RDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEK---II 533
Query: 570 GIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQH-- 627
+ +K++ G + Y + + I L+ RRD AL E+ A ++
Sbjct: 534 TVDKTATKLI--------GDDHYDSENIKAIRD------GLLARRD-ALREKAATRRRLL 578
Query: 628 -NERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKID 686
L ++ ++ + WI K + + L+ ++ + +EK + K +++
Sbjct: 579 KESLLLQKLYEDSDDLKNWINKKKKLADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQLE 638
Query: 687 QLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLL 721
++ Q + E + + + + + WE+LL
Sbjct: 639 NIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELL 673
Score = 43.1 bits (100), Expect = 0.001
Identities = 63/293 (21%), Positives = 118/293 (40%), Gaps = 30/293 (10%)
Query: 218 IPKMLDAED-IVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVN---QENE 273
+P++ D +D ++ KAI ++ + Q E +A K+L Q+ E
Sbjct: 1985 LPEITDLKDKLISAQHNQSKAIEERYAALLKRWE--QLLEASAVHRQKLLEKQLPLQKAE 2042
Query: 274 QLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQ 333
L ++ AS L W + L V +++ ++Q +D D+ + KC
Sbjct: 2043 DLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCL 2102
Query: 334 LEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLD 393
LE L +++ P+ P V + W L + + E+ L E R +
Sbjct: 2103 LE-----LDQQIKALGVPS-SPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNF 2156
Query: 394 HLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQ 453
+ ++F Q AS W ET +LLK+ ES L A++ + ++
Sbjct: 2157 EMCQEFEQNASTFLQWI-----------LETRAYFLDGSLLKETGTLESQLEANKRKQKE 2205
Query: 454 IAAIAQELNEL-----DYYDSPSVNARCQKI--CDQWDNLGALTQKRREALER 499
I A+ ++L ++ + D+ ++ + I QWD L L + + LE+
Sbjct: 2206 IQAMKRQLTKIVDLGDNLEDALILDIKYSTIGLAQQWDQLYQLGLRMQHNLEQ 2258
Score = 33.5 bits (75), Expect = 0.90
Identities = 52/240 (21%), Positives = 91/240 (37%), Gaps = 35/240 (14%)
Query: 231 ARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDL-LEW 289
AR D+ I+T +++++ + A + V E L +KL L L+
Sbjct: 738 ARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQL 797
Query: 290 IRRTIP----WLENRVPENTMHAMQQKLEDFRDYRRLHK---------PPKVQEKCQLEI 336
I R W++ P T + + L + H+ P++QE
Sbjct: 798 ICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQE------ 851
Query: 337 NFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLA 396
++ R M EG ++ + ++ + + E RR L+
Sbjct: 852 ----------ITERGNKMVEEGHFAAE--DVASRVKSLNQNMESLRARAARRQNDLEANV 899
Query: 397 EKFRQKASIHEA--WTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQI 454
+ + A +HEA W KE ++ +Y A ALLKKHEAF DL + D ++ +
Sbjct: 900 QFQQYLADLHEAETWIREKEPIVDNTNYG-ADEEAAGALLKKHEAFLLDLNSFGDSMKAL 958
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.133 0.393
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,249,541
Number of Sequences: 37866
Number of extensions: 1372970
Number of successful extensions: 5118
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 131
Number of HSP's successfully gapped in prelim test: 161
Number of HSP's that attempted gapping in prelim test: 4068
Number of HSP's gapped (non-prelim): 871
length of query: 892
length of database: 18,247,518
effective HSP length: 111
effective length of query: 781
effective length of database: 14,044,392
effective search space: 10968670152
effective search space used: 10968670152
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.