Guide to the Human Genome
Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Search of human proteins with 4501891

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4501891 actinin, alpha 1 isoform b [Homo sapiens]
         (892 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4501891 actinin, alpha 1 isoform b [Homo sapiens]                 1806   0.0  
gi|194097350 actinin, alpha 1 isoform a [Homo sapiens]               1793   0.0  
gi|194097352 actinin, alpha 1 isoform c [Homo sapiens]               1764   0.0  
gi|12025678 actinin, alpha 4 [Homo sapiens]                          1570   0.0  
gi|4501893 actinin, alpha 2 [Homo sapiens]                           1455   0.0  
gi|4557241 actinin, alpha 3 [Homo sapiens]                           1440   0.0  
gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo ...   446   e-125
gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo ...   445   e-125
gi|67782321 spectrin beta isoform a [Homo sapiens]                    431   e-120
gi|67782319 spectrin beta isoform b [Homo sapiens]                    431   e-120
gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens]          427   e-119
gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1 [...   405   e-113
gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens]        344   2e-94
gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ...   288   1e-77
gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ...   288   1e-77
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                       242   1e-63
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                       242   1e-63
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                        242   1e-63
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                        242   1e-63
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                        242   1e-63
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                        242   1e-63
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                        242   1e-63
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                        242   1e-63
gi|169218211 PREDICTED: similar to plectin 1, partial [Homo sapi...   238   2e-62
gi|221316624 dystonin isoform 4 [Homo sapiens]                        236   5e-62
gi|221316622 dystonin isoform 3 [Homo sapiens]                        236   5e-62
gi|221316618 dystonin isoform 2 [Homo sapiens]                        236   5e-62
gi|34577047 dystonin isoform 1 [Homo sapiens]                         236   5e-62
gi|33188445 microfilament and actin filament cross-linker protei...   226   6e-59
gi|115298659 spectrin, alpha, erythrocytic 1 [Homo sapiens]           219   9e-57

>gi|4501891 actinin, alpha 1 isoform b [Homo sapiens]
          Length = 892

 Score = 1806 bits (4677), Expect = 0.0
 Identities = 892/892 (100%), Positives = 892/892 (100%)

Query: 1   MDHYDSQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFR 60
           MDHYDSQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFR
Sbjct: 1   MDHYDSQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFR 60

Query: 61  DGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNV 120
           DGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNV
Sbjct: 61  DGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNV 120

Query: 121 KMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFC 180
           KMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFC
Sbjct: 121 KMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFC 180

Query: 181 ALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMT 240
           ALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMT
Sbjct: 181 ALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMT 240

Query: 241 YVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENR 300
           YVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENR
Sbjct: 241 YVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENR 300

Query: 301 VPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRM 360
           VPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRM
Sbjct: 301 VPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRM 360

Query: 361 VSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQK 420
           VSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQK
Sbjct: 361 VSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQK 420

Query: 421 DYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKIC 480
           DYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKIC
Sbjct: 421 DYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKIC 480

Query: 481 DQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHT 540
           DQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHT
Sbjct: 481 DQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHT 540

Query: 541 IEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEI 600
           IEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEI
Sbjct: 541 IEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEI 600

Query: 601 NGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEM 660
           NGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEM
Sbjct: 601 NGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEM 660

Query: 661 HGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQL 720
           HGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQL
Sbjct: 661 HGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQL 720

Query: 721 LTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGY 780
           LTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGY
Sbjct: 721 LTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGY 780

Query: 781 DIGNDPQGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDK 840
           DIGNDPQGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDK
Sbjct: 781 DIGNDPQGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDK 840

Query: 841 NYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTALYGESDL 892
           NYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTALYGESDL
Sbjct: 841 NYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTALYGESDL 892


>gi|194097350 actinin, alpha 1 isoform a [Homo sapiens]
          Length = 914

 Score = 1793 bits (4644), Expect = 0.0
 Identities = 892/914 (97%), Positives = 892/914 (97%), Gaps = 22/914 (2%)

Query: 1   MDHYDSQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFR 60
           MDHYDSQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFR
Sbjct: 1   MDHYDSQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFR 60

Query: 61  DGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNV 120
           DGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNV
Sbjct: 61  DGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNV 120

Query: 121 KMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFC 180
           KMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFC
Sbjct: 121 KMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFC 180

Query: 181 ALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMT 240
           ALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMT
Sbjct: 181 ALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMT 240

Query: 241 YVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENR 300
           YVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENR
Sbjct: 241 YVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENR 300

Query: 301 VPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRM 360
           VPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRM
Sbjct: 301 VPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRM 360

Query: 361 VSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQK 420
           VSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQK
Sbjct: 361 VSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQK 420

Query: 421 DYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKIC 480
           DYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKIC
Sbjct: 421 DYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKIC 480

Query: 481 DQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHT 540
           DQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHT
Sbjct: 481 DQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHT 540

Query: 541 IEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEI 600
           IEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEI
Sbjct: 541 IEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEI 600

Query: 601 NGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEM 660
           NGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEM
Sbjct: 601 NGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEM 660

Query: 661 HGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQL 720
           HGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQL
Sbjct: 661 HGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQL 720

Query: 721 LTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGY 780
           LTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGY
Sbjct: 721 LTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGY 780

Query: 781 DIGNDPQ----------------------GEAEFARIMSIVDPNRLGVVTFQAFIDFMSR 818
           DIGNDPQ                      GEAEFARIMSIVDPNRLGVVTFQAFIDFMSR
Sbjct: 781 DIGNDPQKKTGMMDTDDFRACLISMGYNMGEAEFARIMSIVDPNRLGVVTFQAFIDFMSR 840

Query: 819 ETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALD 878
           ETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALD
Sbjct: 841 ETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALD 900

Query: 879 YMSFSTALYGESDL 892
           YMSFSTALYGESDL
Sbjct: 901 YMSFSTALYGESDL 914


>gi|194097352 actinin, alpha 1 isoform c [Homo sapiens]
          Length = 887

 Score = 1764 bits (4570), Expect = 0.0
 Identities = 874/892 (97%), Positives = 882/892 (98%), Gaps = 5/892 (0%)

Query: 1   MDHYDSQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFR 60
           MDHYDSQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFR
Sbjct: 1   MDHYDSQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFR 60

Query: 61  DGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNV 120
           DGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNV
Sbjct: 61  DGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNV 120

Query: 121 KMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFC 180
           KMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFC
Sbjct: 121 KMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFC 180

Query: 181 ALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMT 240
           ALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMT
Sbjct: 181 ALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMT 240

Query: 241 YVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENR 300
           YVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENR
Sbjct: 241 YVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENR 300

Query: 301 VPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRM 360
           VPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRM
Sbjct: 301 VPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRM 360

Query: 361 VSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQK 420
           VSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQK
Sbjct: 361 VSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQK 420

Query: 421 DYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKIC 480
           DYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKIC
Sbjct: 421 DYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKIC 480

Query: 481 DQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHT 540
           DQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHT
Sbjct: 481 DQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHT 540

Query: 541 IEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEI 600
           IEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEI
Sbjct: 541 IEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEI 600

Query: 601 NGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEM 660
           NGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEM
Sbjct: 601 NGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEM 660

Query: 661 HGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQL 720
           HGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQL
Sbjct: 661 HGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQL 720

Query: 721 LTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGY 780
           LTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDR  +G +  ++F+ACLIS+GY
Sbjct: 721 LTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRKKTGMMDTDDFRACLISMGY 780

Query: 781 DIGNDPQGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDK 840
           ++     GEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDK
Sbjct: 781 NM-----GEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDK 835

Query: 841 NYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTALYGESDL 892
           NYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTALYGESDL
Sbjct: 836 NYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTALYGESDL 887


>gi|12025678 actinin, alpha 4 [Homo sapiens]
          Length = 911

 Score = 1570 bits (4065), Expect = 0.0
 Identities = 765/882 (86%), Positives = 821/882 (93%)

Query: 11  DYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLE 70
           DYM  E+DWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENI+EDFRDGLKLMLLLE
Sbjct: 30  DYMAQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLE 89

Query: 71  VISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTI 130
           VISGERL KPERGKMRVHKI+NVNKALDFIASKGVKLVSIGAEEIVDGN KMTLGMIWTI
Sbjct: 90  VISGERLPKPERGKMRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTI 149

Query: 131 ILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPEL 190
           ILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVN+QNFHISWKDGL F ALIHRHRPEL
Sbjct: 150 ILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPEL 209

Query: 191 IDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFS 250
           I+Y KLRKDDP+TNLN AF+VAEKYLDIPKMLDAEDIV TARPDEKAIMTYVSSFYHAFS
Sbjct: 210 IEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFS 269

Query: 251 GAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQ 310
           GAQKAETAANRICKVLAVNQENE LMEDYEKLASDLLEWIRRTIPWLE+RVP+ T+  MQ
Sbjct: 270 GAQKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQ 329

Query: 311 QKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGC 370
           QKLEDFRDYRR+HKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEG+MVSDINN W  
Sbjct: 330 QKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQH 389

Query: 371 LEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEI 430
           LEQ EKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAML+ +DYETATLS+I
Sbjct: 390 LEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDI 449

Query: 431 KALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALT 490
           KAL++KHEAFESDLAAHQDRVEQIAAIAQELNELDYYDS +VN RCQKICDQWD LG+LT
Sbjct: 450 KALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLT 509

Query: 491 QKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTA 550
             RREALE+TEK LE IDQL+LEYAKRAAPFNNWME AMEDLQD FIVHTIEEI+GL +A
Sbjct: 510 HSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISA 569

Query: 551 HEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQL 610
           H+QFK+TLPDAD+ER AIL IH E  +I ++ H+ ++G+NPYTT+TPQ IN KW+ V+QL
Sbjct: 570 HDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQL 629

Query: 611 VPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSH 670
           VP+RD AL EE ++QQ NE LR+QF +QANV+GPWIQTKMEEIGRISIEM+GTLEDQLSH
Sbjct: 630 VPKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTKMEEIGRISIEMNGTLEDQLSH 689

Query: 671 LRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINE 730
           L+QYE+SIV+YKP +D LE  HQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINE
Sbjct: 690 LKQYERSIVDYKPNLDLLEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINE 749

Query: 731 VENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQGEA 790
           VENQILTRDAKGISQEQM EFRASFNHFD+DH G LGPEEFKACLISLGYD+ ND QGEA
Sbjct: 750 VENQILTRDAKGISQEQMQEFRASFNHFDKDHGGALGPEEFKACLISLGYDVENDRQGEA 809

Query: 791 EFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELRR 850
           EF RIMS+VDPN  G+VTFQAFIDFMSRET DTDTADQV+ASFK+LAGDKN+IT +ELRR
Sbjct: 810 EFNRIMSLVDPNHSGLVTFQAFIDFMSRETTDTDTADQVIASFKVLAGDKNFITAEELRR 869

Query: 851 ELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTALYGESDL 892
           ELPPDQAEYCIARMAPY GPD+VPGALDY SFSTALYGESDL
Sbjct: 870 ELPPDQAEYCIARMAPYQGPDAVPGALDYKSFSTALYGESDL 911


>gi|4501893 actinin, alpha 2 [Homo sapiens]
          Length = 894

 Score = 1455 bits (3766), Expect = 0.0
 Identities = 709/883 (80%), Positives = 794/883 (89%), Gaps = 5/883 (0%)

Query: 10  NDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLL 69
           ++YM  EE+WDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFR+GLKLMLLL
Sbjct: 17  DEYMIQEEEWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLL 76

Query: 70  EVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWT 129
           EVISGERL KP+RGKMR HKI+NVNKALD+IASKGVKLVSIGAEEIVDGNVKMTLGMIWT
Sbjct: 77  EVISGERLPKPDRGKMRFHKIANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTLGMIWT 136

Query: 130 IILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPE 189
           IILRFAIQDISVEETSAKEGLLLWCQRKTAPY+NVNIQNFH SWKDGLG CALIHRHRP+
Sbjct: 137 IILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPD 196

Query: 190 LIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAF 249
           LIDY KL KDDP+ N+N A ++AEK+LDIPKMLDAEDIV T +PDE+AIMTYVS FYHAF
Sbjct: 197 LIDYSKLNKDDPIGNINLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAF 256

Query: 250 SGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAM 309
           +GA++AETAANRICKVLAVNQENE+LME+YE+LAS+LLEWIRRTIPWLENR PE TM AM
Sbjct: 257 AGAEQAETAANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAM 316

Query: 310 QQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWG 369
           Q+KLEDFRDYRR HKPPKVQEKCQLEINFNTLQTKLR+SNRPAFMPSEG+MVSDI  AW 
Sbjct: 317 QKKLEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQ 376

Query: 370 CLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSE 429
            LEQ EKGYEEWLLNEIRRLERL+HLAEKFRQKAS HE W  GKE +L QKDYE+A+L+E
Sbjct: 377 RLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTE 436

Query: 430 IKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGAL 489
           ++ALL+KHEAFESDLAAHQDRVEQIAAIAQELNELDY+D+ +VN RCQKICDQWD LG L
Sbjct: 437 VRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTL 496

Query: 490 TQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTT 549
           TQKRREALER EKLLETIDQL+LE+AKRAAPFNNWMEGAMEDLQD FIVH+IEEIQ L T
Sbjct: 497 TQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLIT 556

Query: 550 AHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQ 609
           AHEQFKATLP+AD ER +I+ I NEV K++Q+Y++ ++ +NPY+T+T  E+  KWD V+Q
Sbjct: 557 AHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQ 616

Query: 610 LVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLS 669
           LVP RDQ+L EE ARQ  NERLR+QF AQAN IGPWIQ KMEEI R SI++ G LEDQ++
Sbjct: 617 LVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITGALEDQMN 676

Query: 670 HLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTIN 729
            L+QYE +I+NYK  ID+LEGDHQLIQEAL+FDNKHTNYTMEHIRVGWE LLTTIARTIN
Sbjct: 677 QLKQYEHNIINYKNNIDKLEGDHQLIQEALVFDNKHTNYTMEHIRVGWELLLTTIARTIN 736

Query: 730 EVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQGE 789
           EVE QILTRDAKGI+QEQMNEFRASFNHFDR  +G +  E+F+ACLIS+GYD+     GE
Sbjct: 737 EVETQILTRDAKGITQEQMNEFRASFNHFDRRKNGLMDHEDFRACLISMGYDL-----GE 791

Query: 790 AEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELR 849
           AEFARIM++VDPN  G VTFQ+FIDFM+RETADTDTA+QV+ASF+ILA DK YI  +ELR
Sbjct: 792 AEFARIMTLVDPNGQGTVTFQSFIDFMTRETADTDTAEQVIASFRILASDKPYILAEELR 851

Query: 850 RELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTALYGESDL 892
           RELPPDQA+YCI RM  Y+GP SVPGALDY +FS+ALYGESDL
Sbjct: 852 RELPPDQAQYCIKRMPAYSGPGSVPGALDYAAFSSALYGESDL 894


>gi|4557241 actinin, alpha 3 [Homo sapiens]
          Length = 901

 Score = 1440 bits (3727), Expect = 0.0
 Identities = 693/882 (78%), Positives = 797/882 (90%), Gaps = 5/882 (0%)

Query: 11  DYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLE 70
           +YM+ EEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFR+GLKLMLLLE
Sbjct: 25  EYMEQEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLE 84

Query: 71  VISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTI 130
           VISGERL +P++GKMR HKI+NVNKALDFIASKGVKLVSIGAEEIVDGN+KMTLGMIWTI
Sbjct: 85  VISGERLPRPDKGKMRFHKIANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTI 144

Query: 131 ILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPEL 190
           ILRFAIQDISVEETSAKEGLLLWCQRKTAPY+NVN+QNFH SWKDGL  CALIHRHRP+L
Sbjct: 145 ILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPDL 204

Query: 191 IDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFS 250
           IDY KLRKDDP+ NLNTAF+VAEKYLDIPKMLDAEDIV T +PDEKAIMTYVS FYHAF+
Sbjct: 205 IDYAKLRKDDPIGNLNTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFA 264

Query: 251 GAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQ 310
           GA++AETAANRICKVLAVNQENE+LME+YEKLAS+LLEWIRRT+PWLENRV E +M AMQ
Sbjct: 265 GAEQAETAANRICKVLAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQ 324

Query: 311 QKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGC 370
           +KLEDFRDYRRLHKPP++QEKCQLEINFNTLQTKLRLS+RPAFMPSEG++VSDI NAW  
Sbjct: 325 RKLEDFRDYRRLHKPPRIQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRG 384

Query: 371 LEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEI 430
           LEQVEKGYE+WLL+EIRRL+RL HLAEKFRQKAS+HEAWT GKE ML Q+DY++A L E+
Sbjct: 385 LEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEV 444

Query: 431 KALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALT 490
           +ALL++HEAFESDLAAHQDRVE IAA+AQELNELDY+++ SVN+RCQ ICDQWDNLG LT
Sbjct: 445 RALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLT 504

Query: 491 QKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTA 550
           QKRR+ALER EKLLETIDQL LE+A+RAAPFNNW++GA+EDLQD ++VH++EE Q L TA
Sbjct: 505 QKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTA 564

Query: 551 HEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQL 610
           H+QFKATLP+AD+ER AI+GI  E+ KI QTY +    TNPY T++PQ+IN KWD VR+L
Sbjct: 565 HDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKL 624

Query: 611 VPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSH 670
           VP RDQ L EE ARQQ NERLR+QF AQAN IGPWIQ K+EE+GR++  + G+LE+Q++ 
Sbjct: 625 VPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQAKVEEVGRLAAGLAGSLEEQMAG 684

Query: 671 LRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINE 730
           LRQ E++I+NYK  ID+LEGDHQL+QE+L+FDNKHT Y+MEHIRVGWEQLLT+IARTINE
Sbjct: 685 LRQQEQNIINYKTNIDRLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLLTSIARTINE 744

Query: 731 VENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQGEA 790
           VENQ+LTRDAKG+SQEQ+NEFRASFNHFDR  +G + P++F+ACLIS+GYD+     GE 
Sbjct: 745 VENQVLTRDAKGLSQEQLNEFRASFNHFDRKRNGMMEPDDFRACLISMGYDL-----GEV 799

Query: 791 EFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELRR 850
           EFARIM++VDPN  GVVTFQAFIDFM+RETA+TDT +QV+ASFKILAGDKNYIT +ELRR
Sbjct: 800 EFARIMTMVDPNAAGVVTFQAFIDFMTRETAETDTTEQVVASFKILAGDKNYITPEELRR 859

Query: 851 ELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTALYGESDL 892
           ELP  QAEYCI RM PY G  +  GALDY++FS+ALYGESDL
Sbjct: 860 ELPAKQAEYCIRRMVPYKGSGAPAGALDYVAFSSALYGESDL 901


>gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo
           sapiens]
          Length = 2155

 Score =  446 bits (1146), Expect = e-125
 Identities = 279/722 (38%), Positives = 408/722 (56%), Gaps = 54/722 (7%)

Query: 4   YDSQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGL 63
           Y  Q   +Y Q E  + +   L    E  Q+KTFT W NSHL +   +I ++  D RDG 
Sbjct: 17  YTGQVPYNYNQLEGRFKQ---LQDEREAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGR 73

Query: 64  KLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMT 123
            L+ LLEV+SGERL KP +G+MR+H + NV+KAL F+  + V L ++G+ +IVDGN ++T
Sbjct: 74  MLIKLLEVLSGERLPKPTKGRMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLT 133

Query: 124 LGMIWTIILRFAIQDISVE------ETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGL 177
           LG+IWTIILRF IQDISVE      + SAK+ LLLWCQ KTA Y NVNI NF  SW+DG+
Sbjct: 134 LGLIWTIILRFQIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGM 193

Query: 178 GFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKA 237
            F ALIH+HRP+LID+ KL+K +   NL  AF++AE++L + K+LD EDI     PDEK+
Sbjct: 194 AFNALIHKHRPDLIDFDKLKKSNAHYNLQNAFNLAEQHLGLTKLLDPEDI-SVDHPDEKS 252

Query: 238 IMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWL 297
           I+TYV ++YH FS  +       RI KVL    E E+++E YE LASDLLEWI +TI  L
Sbjct: 253 IITYVVTYYHYFSKMKALAVEGKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIIL 312

Query: 298 ENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSE 357
            NR   N++  +QQ+L+ F  YR + KPPK  EK  LE+   T+Q+K+R +N+  +MP E
Sbjct: 313 NNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPRE 372

Query: 358 GRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAML 417
           G+++SDIN AW  LE+ E   E  L NE+ R E+L+ LA +F +KA++ E W    + ++
Sbjct: 373 GKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLV 432

Query: 418 RQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQ 477
            Q ++    L  ++A  KKHEA E+D+AA+++RV+ + A+A+EL   +Y+D   + AR  
Sbjct: 433 SQDNF-GFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKD 491

Query: 478 KICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWM-EGAMEDLQDTF 536
            +   W+ L  L + RR+ LE    L +   ++            +WM E  +  L   +
Sbjct: 492 NVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLY--------IMDWMDEMKVLVLSQDY 543

Query: 537 IVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNE----VSKIVQTYHVNMAGTNPY 592
             H +  ++ L   H     TL +AD      +GI  E    V+   Q +  +  G   Y
Sbjct: 544 GKHLL-GVEDLLQKH-----TLVEAD------IGIQAERVRGVNASAQKFATDGEG---Y 588

Query: 593 TTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTK--- 649
               PQ I  +  H+        Q   E  AR + + RL K F   A   G WI+ K   
Sbjct: 589 KPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEG-WIREKEKI 647

Query: 650 ---------MEEIGRISIEMHGTLEDQLS-HLRQYEKSIVNYKPKIDQLEGDHQLIQEAL 699
                    +  + R+ +  H   ED++S     +E++I   +  I +     + I+E +
Sbjct: 648 LSSDDYGKDLTSVMRL-LSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERI 706

Query: 700 IF 701
           I+
Sbjct: 707 IY 708



 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 64/271 (23%), Positives = 108/271 (39%), Gaps = 26/271 (9%)

Query: 388 RLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAH 447
           RLE    L + F + A   E W   KE +L   DY    L+ +  LL KH AFE +++  
Sbjct: 620 RLEESRRLWKFFWEMAE-EEGWIREKEKILSSDDYGK-DLTSVMRLLSKHRAFEDEMSGR 677

Query: 448 QDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETI 507
               EQ     +++   +++ S  +  R   I +QW NL  L+  R++ LE         
Sbjct: 678 SGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEA------- 730

Query: 508 DQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLA 567
             L  ++   A   + WM   ++ +  + + H     Q L   H   K    +    R  
Sbjct: 731 -SLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKH---KDVAEEIANYRPT 786

Query: 568 ILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQH 627
           +  +H + S + Q +       +P        I  ++  V +L   R QAL +  A    
Sbjct: 787 LDTLHEQASALPQEH-----AESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLA---- 837

Query: 628 NERLRKQFGAQANVIGPWIQTKMEEIGRISI 658
              L K F ++A+    WI  K + +  + I
Sbjct: 838 ---LYKMF-SEADACELWIDEKEQWLNNMQI 864



 Score = 57.4 bits (137), Expect = 6e-08
 Identities = 83/424 (19%), Positives = 161/424 (37%), Gaps = 45/424 (10%)

Query: 210  DVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVN 269
            DVAE+  +    LD      +A P E A    V           K      R+ K     
Sbjct: 775  DVAEEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRK----- 829

Query: 270  QENEQLMEDYEKLA-SDLLE-WIRRTIPWLEN-RVPENTMHAMQQKLEDFR--DYRRLHK 324
            Q  +  +  Y+  + +D  E WI     WL N ++PE        KLED     +R    
Sbjct: 830  QALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPE--------KLEDLEVIQHRFESL 881

Query: 325  PPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLN 384
             P++  +       N +  +L  S  P+    + +    +N  W    ++    ++ LL+
Sbjct: 882  EPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQ-DKLNTRWSQFRELVDRKKDALLS 940

Query: 385  EIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDL 444
             +          + +  + +  ++W   K  ++         L+ + AL +K    E DL
Sbjct: 941  ALS--------IQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDL 992

Query: 445  AAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLL 504
             A + ++  +   A++L       + ++ +R  +I D W+ +    + R  +L    KL 
Sbjct: 993  VAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQ 1052

Query: 505  ETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLP--DAD 562
            + +  L          F +W+      +    + +T+ E + L T HE  K  +   + D
Sbjct: 1053 QFLRDL--------DDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEED 1104

Query: 563  KERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEH 622
             +++  +G   E+    QT    M     +     Q ++  W+ + ++   R   L++ H
Sbjct: 1105 YQKMRDMG---EMVTQGQTDAQYM-----FLRQRLQALDTGWNELHKMWENRQNLLSQSH 1156

Query: 623  ARQQ 626
            A QQ
Sbjct: 1157 AYQQ 1160



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 76/366 (20%), Positives = 149/366 (40%), Gaps = 40/366 (10%)

Query: 361  VSDINNAWGCL-EQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQ 419
            ++D+   WG L E+ EK +        RRLE   H A+++   A+  EAW   +E  +  
Sbjct: 1554 LADLKQLWGLLIEETEKRH--------RRLEEA-HRAQQYYFDAAEAEAWMSEQELYMMS 1604

Query: 420  KDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKI 479
            ++      S + ++LKKH+  E  +  + + V Q++  ++ L    + +S  ++ R  K+
Sbjct: 1605 EEKAKDEQSAV-SMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKV 1663

Query: 480  CDQWDNLGALTQKRREALERTEKLLE---TIDQLYLEYAKRAAPFNNWMEGAMEDLQDTF 536
               +  L  L ++RR  L+   +L +    +D L    A+R       + G+ E  QD  
Sbjct: 1664 DKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREV-----VAGSHELGQD-- 1716

Query: 537  IVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTIT 596
                 E +  L     +F     +  +ER+    +++   +++ + H + A    +    
Sbjct: 1717 ----YEHVTMLQERFREFARDTGNIGQERVDT--VNHLADELINSGHSDAATIAEW---- 1766

Query: 597  PQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRI 656
               +N  W  + +L+  R Q L   +   +     ++ FG         IQ K +++   
Sbjct: 1767 KDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGR--------IQDKHKKLPEE 1818

Query: 657  SIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEH-IRV 715
                  T+E        +E  I     ++ QL+ D   +Q A   D        E+ +  
Sbjct: 1819 LGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLE 1878

Query: 716  GWEQLL 721
             W+ LL
Sbjct: 1879 AWKSLL 1884



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 70/366 (19%), Positives = 156/366 (42%), Gaps = 41/366 (11%)

Query: 364  INNAWGCLEQVEKGYEEWLLNEIRRLERLDH--LAEKFRQKASIHEAWTDGKEAMLRQKD 421
            I   W  LEQ         L+ IR+ +RL+   L  +F+  A   +AW      ++   D
Sbjct: 709  IREQWANLEQ---------LSAIRK-KRLEEASLLHQFQADADDIDAWMLDILKIVSSSD 758

Query: 422  YETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICD 481
                  S  ++L+KKH+    ++A ++  ++ +   A  L + ++ +SP V  R   I +
Sbjct: 759  VGHDEYST-QSLVKKHKDVAEEIANYRPTLDTLHEQASALPQ-EHAESPDVRGRLSGIEE 816

Query: 482  QWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTI 541
            ++  +  LT+ R++AL+ T  L +   +        A     W++   + L +  I   +
Sbjct: 817  RYKEVAELTRLRKQALQDTLALYKMFSE--------ADACELWIDEKEQWLNNMQIPEKL 868

Query: 542  EEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEIN 601
            E+++ +     +F++  P+ + +   +  ++    +++ + H +             ++N
Sbjct: 869  EDLEVI---QHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPS----EKEIKAQQDKLN 921

Query: 602  GKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTK---MEEIGRISI 658
             +W   R+LV R+  AL    + Q ++         + N    WI+ K   +E    +  
Sbjct: 922  TRWSQFRELVDRKKDALLSALSIQNYH--------LECNETKSWIREKTKVIESTQDLGN 973

Query: 659  EMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWE 718
            ++ G +  Q   L   E+ +V  + K+  L+ + + ++       +     +  I   WE
Sbjct: 974  DLAGVMALQ-RKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWE 1032

Query: 719  QLLTTI 724
            ++ TT+
Sbjct: 1033 EMKTTL 1038



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 41/189 (21%), Positives = 86/189 (45%), Gaps = 18/189 (9%)

Query: 385  EIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETAT--LSEIKALLKKHEAFES 442
            E RR+  +D   +KFR  + + +      E ++RQ + +     +S ++ L+  H+  ++
Sbjct: 1888 ESRRVRLVD-TGDKFRFFSMVRDLML-WMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKA 1945

Query: 443  DLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEK 502
            ++ A  D       + + L    +Y S  +           + L  LT+KR+E +++ E 
Sbjct: 1946 EIDARNDSFTTCIELGKSLLARKHYASEEIK----------EKLLQLTEKRKEMIDKWED 1995

Query: 503  LLETIDQLYLE---YAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLP 559
              E + +L LE   +++ A+    W+ G    L    I  +++E++ L   HE F+ +  
Sbjct: 1996 RWEWL-RLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAA 2054

Query: 560  DADKERLAI 568
              D+   A+
Sbjct: 2055 TWDERFSAL 2063



 Score = 40.0 bits (92), Expect = 0.010
 Identities = 24/79 (30%), Positives = 40/79 (50%), Gaps = 7/79 (8%)

Query: 372  EQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIK 431
            E ++K  + W         RL     +F + AS+ EAW  G+E  L  ++   + + E++
Sbjct: 1988 EMIDKWEDRW------EWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQS-VDEVE 2040

Query: 432  ALLKKHEAFESDLAAHQDR 450
             L+K+HEAFE   A   +R
Sbjct: 2041 KLIKRHEAFEKSAATWDER 2059



 Score = 38.5 bits (88), Expect = 0.028
 Identities = 19/68 (27%), Positives = 36/68 (52%), Gaps = 1/68 (1%)

Query: 396  AEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIA 455
            AE F Q  +  + W  G E+ ++  DY    L+ +  LLKK +  E+ +   +  +E++ 
Sbjct: 1369 AELFTQSCADLDKWLHGLESQIQSDDYGK-DLTSVNILLKKQQMLENQMEVRKKEIEELQ 1427

Query: 456  AIAQELNE 463
            + AQ L++
Sbjct: 1428 SQAQALSQ 1435



 Score = 36.6 bits (83), Expect = 0.11
 Identities = 33/157 (21%), Positives = 65/157 (41%), Gaps = 9/157 (5%)

Query: 427  LSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQEL-NELDYYDSPSVNARCQKICDQWDN 485
            L  ++ L+KK++  + ++  HQ R++ I   +Q +  +     + ++  R   +   W  
Sbjct: 1504 LQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGL 1563

Query: 486  LGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNN---WMEGAMEDLQDTFIVHTIE 542
            L   T+KR   LE   +      Q Y + A+  A  +    +M    +   +   V  ++
Sbjct: 1564 LIEETEKRHRRLEEAHR----AQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLK 1619

Query: 543  EIQGLTTAHEQFKATLPDADK-ERLAILGIHNEVSKI 578
            + Q L  A E +  T+    K  R  +   H E  +I
Sbjct: 1620 KHQILEQAVEDYAETVHQLSKTSRALVADSHPESERI 1656



 Score = 33.1 bits (74), Expect = 1.2
 Identities = 29/137 (21%), Positives = 56/137 (40%), Gaps = 10/137 (7%)

Query: 397  EKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAA 456
            +KF Q       W + K    +   Y+ A     K L  KH+AF ++LA++++ +++I  
Sbjct: 1265 QKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWL--KHQAFMAELASNKEWLDKIEK 1322

Query: 457  IAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAK 516
               +L          V  +   +   W+ L + TQ + + L    K      +L   + +
Sbjct: 1323 EGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKA-----EL---FTQ 1374

Query: 517  RAAPFNNWMEGAMEDLQ 533
              A  + W+ G    +Q
Sbjct: 1375 SCADLDKWLHGLESQIQ 1391


>gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo
           sapiens]
          Length = 2364

 Score =  445 bits (1145), Expect = e-125
 Identities = 273/696 (39%), Positives = 399/696 (57%), Gaps = 51/696 (7%)

Query: 30  EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHK 89
           E  Q+KTFT W NSHL +   +I ++  D RDG  L+ LLEV+SGERL KP +G+MR+H 
Sbjct: 53  EAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKPTKGRMRIHC 112

Query: 90  ISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVE------E 143
           + NV+KAL F+  + V L ++G+ +IVDGN ++TLG+IWTIILRF IQDISVE      +
Sbjct: 113 LENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDNKEK 172

Query: 144 TSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLT 203
            SAK+ LLLWCQ KTA Y NVNI NF  SW+DG+ F ALIH+HRP+LID+ KL+K +   
Sbjct: 173 KSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSNAHY 232

Query: 204 NLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRIC 263
           NL  AF++AE++L + K+LD EDI     PDEK+I+TYV ++YH FS  +       RI 
Sbjct: 233 NLQNAFNLAEQHLGLTKLLDPEDI-SVDHPDEKSIITYVVTYYHYFSKMKALAVEGKRIG 291

Query: 264 KVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLH 323
           KVL    E E+++E YE LASDLLEWI +TI  L NR   N++  +QQ+L+ F  YR + 
Sbjct: 292 KVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVE 351

Query: 324 KPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLL 383
           KPPK  EK  LE+   T+Q+K+R +N+  +MP EG+++SDIN AW  LE+ E   E  L 
Sbjct: 352 KPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALR 411

Query: 384 NEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESD 443
           NE+ R E+L+ LA +F +KA++ E W    + ++ Q ++    L  ++A  KKHEA E+D
Sbjct: 412 NELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNF-GFDLPAVEAATKKHEAIETD 470

Query: 444 LAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKL 503
           +AA+++RV+ + A+A+EL   +Y+D   + AR   +   W+ L  L + RR+ LE    L
Sbjct: 471 IAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGL 530

Query: 504 LETIDQLYLEYAKRAAPFNNWM-EGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDAD 562
            +   ++            +WM E  +  L   +  H +  ++ L   H     TL +AD
Sbjct: 531 QKIFQEMLY--------IMDWMDEMKVLVLSQDYGKHLL-GVEDLLQKH-----TLVEAD 576

Query: 563 KERLAILGIHNE----VSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQAL 618
                 +GI  E    V+   Q +  +  G   Y    PQ I  +  H+        Q  
Sbjct: 577 ------IGIQAERVRGVNASAQKFATDGEG---YKPCDPQVIRDRVAHMEFCYQELCQLA 627

Query: 619 TEEHARQQHNERLRKQFGAQANVIGPWIQTK------------MEEIGRISIEMHGTLED 666
            E  AR + + RL K F   A   G WI+ K            +  + R+ +  H   ED
Sbjct: 628 AERRARLEESRRLWKFFWEMAEEEG-WIREKEKILSSDDYGKDLTSVMRL-LSKHRAFED 685

Query: 667 QLS-HLRQYEKSIVNYKPKIDQLEGDHQLIQEALIF 701
           ++S     +E++I   +  I +     + I+E +I+
Sbjct: 686 EMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIY 721



 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 64/271 (23%), Positives = 108/271 (39%), Gaps = 26/271 (9%)

Query: 388 RLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAH 447
           RLE    L + F + A   E W   KE +L   DY    L+ +  LL KH AFE +++  
Sbjct: 633 RLEESRRLWKFFWEMAE-EEGWIREKEKILSSDDYGK-DLTSVMRLLSKHRAFEDEMSGR 690

Query: 448 QDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETI 507
               EQ     +++   +++ S  +  R   I +QW NL  L+  R++ LE         
Sbjct: 691 SGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEA------- 743

Query: 508 DQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLA 567
             L  ++   A   + WM   ++ +  + + H     Q L   H   K    +    R  
Sbjct: 744 -SLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKH---KDVAEEIANYRPT 799

Query: 568 ILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQH 627
           +  +H + S + Q +       +P        I  ++  V +L   R QAL +  A    
Sbjct: 800 LDTLHEQASALPQEH-----AESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLA---- 850

Query: 628 NERLRKQFGAQANVIGPWIQTKMEEIGRISI 658
              L K F ++A+    WI  K + +  + I
Sbjct: 851 ---LYKMF-SEADACELWIDEKEQWLNNMQI 877



 Score = 57.4 bits (137), Expect = 6e-08
 Identities = 83/424 (19%), Positives = 161/424 (37%), Gaps = 45/424 (10%)

Query: 210  DVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVN 269
            DVAE+  +    LD      +A P E A    V           K      R+ K     
Sbjct: 788  DVAEEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRK----- 842

Query: 270  QENEQLMEDYEKLA-SDLLE-WIRRTIPWLEN-RVPENTMHAMQQKLEDFR--DYRRLHK 324
            Q  +  +  Y+  + +D  E WI     WL N ++PE        KLED     +R    
Sbjct: 843  QALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPE--------KLEDLEVIQHRFESL 894

Query: 325  PPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLN 384
             P++  +       N +  +L  S  P+    + +    +N  W    ++    ++ LL+
Sbjct: 895  EPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQ-DKLNTRWSQFRELVDRKKDALLS 953

Query: 385  EIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDL 444
             +          + +  + +  ++W   K  ++         L+ + AL +K    E DL
Sbjct: 954  ALS--------IQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDL 1005

Query: 445  AAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLL 504
             A + ++  +   A++L       + ++ +R  +I D W+ +    + R  +L    KL 
Sbjct: 1006 VAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQ 1065

Query: 505  ETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLP--DAD 562
            + +  L          F +W+      +    + +T+ E + L T HE  K  +   + D
Sbjct: 1066 QFLRDL--------DDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEED 1117

Query: 563  KERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEH 622
             +++  +G   E+    QT    M     +     Q ++  W+ + ++   R   L++ H
Sbjct: 1118 YQKMRDMG---EMVTQGQTDAQYM-----FLRQRLQALDTGWNELHKMWENRQNLLSQSH 1169

Query: 623  ARQQ 626
            A QQ
Sbjct: 1170 AYQQ 1173



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 76/366 (20%), Positives = 149/366 (40%), Gaps = 40/366 (10%)

Query: 361  VSDINNAWGCL-EQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQ 419
            ++D+   WG L E+ EK +        RRLE   H A+++   A+  EAW   +E  +  
Sbjct: 1567 LADLKQLWGLLIEETEKRH--------RRLEEA-HRAQQYYFDAAEAEAWMSEQELYMMS 1617

Query: 420  KDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKI 479
            ++      S + ++LKKH+  E  +  + + V Q++  ++ L    + +S  ++ R  K+
Sbjct: 1618 EEKAKDEQSAV-SMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKV 1676

Query: 480  CDQWDNLGALTQKRREALERTEKLLE---TIDQLYLEYAKRAAPFNNWMEGAMEDLQDTF 536
               +  L  L ++RR  L+   +L +    +D L    A+R       + G+ E  QD  
Sbjct: 1677 DKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREV-----VAGSHELGQD-- 1729

Query: 537  IVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTIT 596
                 E +  L     +F     +  +ER+    +++   +++ + H + A    +    
Sbjct: 1730 ----YEHVTMLQERFREFARDTGNIGQERVDT--VNHLADELINSGHSDAATIAEW---- 1779

Query: 597  PQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRI 656
               +N  W  + +L+  R Q L   +   +     ++ FG         IQ K +++   
Sbjct: 1780 KDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGR--------IQDKHKKLPEE 1831

Query: 657  SIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEH-IRV 715
                  T+E        +E  I     ++ QL+ D   +Q A   D        E+ +  
Sbjct: 1832 LGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLE 1891

Query: 716  GWEQLL 721
             W+ LL
Sbjct: 1892 AWKSLL 1897



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 70/366 (19%), Positives = 156/366 (42%), Gaps = 41/366 (11%)

Query: 364  INNAWGCLEQVEKGYEEWLLNEIRRLERLDH--LAEKFRQKASIHEAWTDGKEAMLRQKD 421
            I   W  LEQ         L+ IR+ +RL+   L  +F+  A   +AW      ++   D
Sbjct: 722  IREQWANLEQ---------LSAIRK-KRLEEASLLHQFQADADDIDAWMLDILKIVSSSD 771

Query: 422  YETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICD 481
                  S  ++L+KKH+    ++A ++  ++ +   A  L + ++ +SP V  R   I +
Sbjct: 772  VGHDEYST-QSLVKKHKDVAEEIANYRPTLDTLHEQASALPQ-EHAESPDVRGRLSGIEE 829

Query: 482  QWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTI 541
            ++  +  LT+ R++AL+ T  L +   +        A     W++   + L +  I   +
Sbjct: 830  RYKEVAELTRLRKQALQDTLALYKMFSE--------ADACELWIDEKEQWLNNMQIPEKL 881

Query: 542  EEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEIN 601
            E+++ +     +F++  P+ + +   +  ++    +++ + H +             ++N
Sbjct: 882  EDLEVI---QHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPS----EKEIKAQQDKLN 934

Query: 602  GKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTK---MEEIGRISI 658
             +W   R+LV R+  AL    + Q ++         + N    WI+ K   +E    +  
Sbjct: 935  TRWSQFRELVDRKKDALLSALSIQNYH--------LECNETKSWIREKTKVIESTQDLGN 986

Query: 659  EMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWE 718
            ++ G +  Q   L   E+ +V  + K+  L+ + + ++       +     +  I   WE
Sbjct: 987  DLAGVMALQ-RKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWE 1045

Query: 719  QLLTTI 724
            ++ TT+
Sbjct: 1046 EMKTTL 1051



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 41/189 (21%), Positives = 86/189 (45%), Gaps = 18/189 (9%)

Query: 385  EIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETAT--LSEIKALLKKHEAFES 442
            E RR+  +D   +KFR  + + +      E ++RQ + +     +S ++ L+  H+  ++
Sbjct: 1901 ESRRVRLVD-TGDKFRFFSMVRDLML-WMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKA 1958

Query: 443  DLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEK 502
            ++ A  D       + + L    +Y S  +           + L  LT+KR+E +++ E 
Sbjct: 1959 EIDARNDSFTTCIELGKSLLARKHYASEEIK----------EKLLQLTEKRKEMIDKWED 2008

Query: 503  LLETIDQLYLE---YAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLP 559
              E + +L LE   +++ A+    W+ G    L    I  +++E++ L   HE F+ +  
Sbjct: 2009 RWEWL-RLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAA 2067

Query: 560  DADKERLAI 568
              D+   A+
Sbjct: 2068 TWDERFSAL 2076



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 35/153 (22%), Positives = 66/153 (43%), Gaps = 23/153 (15%)

Query: 372  EQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIK 431
            E ++K  + W         RL     +F + AS+ EAW  G+E  L  ++   + + E++
Sbjct: 2001 EMIDKWEDRW------EWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQS-VDEVE 2053

Query: 432  ALLKKHEAFESDLAAHQDRVE--------QIAAIAQELNELDYYDSPSVNARCQKICD-- 481
             L+K+HEAFE   A   +R          ++  + ++  E +    P       K+ +  
Sbjct: 2054 KLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRPPSPEPSTKVSEEA 2113

Query: 482  ----QWDNLGA--LTQKRREALERTEKLLETID 508
                QWD      ++Q    A + + ++ ET+D
Sbjct: 2114 ESQQQWDTSKGEQVSQNGLPAEQGSPRMAETVD 2146



 Score = 38.5 bits (88), Expect = 0.028
 Identities = 19/68 (27%), Positives = 36/68 (52%), Gaps = 1/68 (1%)

Query: 396  AEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIA 455
            AE F Q  +  + W  G E+ ++  DY    L+ +  LLKK +  E+ +   +  +E++ 
Sbjct: 1382 AELFTQSCADLDKWLHGLESQIQSDDYGK-DLTSVNILLKKQQMLENQMEVRKKEIEELQ 1440

Query: 456  AIAQELNE 463
            + AQ L++
Sbjct: 1441 SQAQALSQ 1448



 Score = 36.6 bits (83), Expect = 0.11
 Identities = 33/157 (21%), Positives = 65/157 (41%), Gaps = 9/157 (5%)

Query: 427  LSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQEL-NELDYYDSPSVNARCQKICDQWDN 485
            L  ++ L+KK++  + ++  HQ R++ I   +Q +  +     + ++  R   +   W  
Sbjct: 1517 LQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGL 1576

Query: 486  LGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNN---WMEGAMEDLQDTFIVHTIE 542
            L   T+KR   LE   +      Q Y + A+  A  +    +M    +   +   V  ++
Sbjct: 1577 LIEETEKRHRRLEEAHR----AQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLK 1632

Query: 543  EIQGLTTAHEQFKATLPDADK-ERLAILGIHNEVSKI 578
            + Q L  A E +  T+    K  R  +   H E  +I
Sbjct: 1633 KHQILEQAVEDYAETVHQLSKTSRALVADSHPESERI 1669



 Score = 33.1 bits (74), Expect = 1.2
 Identities = 29/137 (21%), Positives = 56/137 (40%), Gaps = 10/137 (7%)

Query: 397  EKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAA 456
            +KF Q       W + K    +   Y+ A     K L  KH+AF ++LA++++ +++I  
Sbjct: 1278 QKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWL--KHQAFMAELASNKEWLDKIEK 1335

Query: 457  IAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAK 516
               +L          V  +   +   W+ L + TQ + + L    K      +L   + +
Sbjct: 1336 EGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKA-----EL---FTQ 1387

Query: 517  RAAPFNNWMEGAMEDLQ 533
              A  + W+ G    +Q
Sbjct: 1388 SCADLDKWLHGLESQIQ 1404


>gi|67782321 spectrin beta isoform a [Homo sapiens]
          Length = 2328

 Score =  431 bits (1107), Expect = e-120
 Identities = 260/715 (36%), Positives = 390/715 (54%), Gaps = 34/715 (4%)

Query: 30  EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHK 89
           E  Q+KTFT W NSHL +   +I ++ +D RDG  L+ LLEV+SGE L KP +GKMR+H 
Sbjct: 53  EVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMRIHC 112

Query: 90  ISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISV------EE 143
           + NV+KAL F+  + V L ++G+ +IVDGN ++ LG+IWTIILRF IQDI V      E 
Sbjct: 113 LENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEGRET 172

Query: 144 TSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLT 203
            SAK+ LLLWCQ KTA Y +VN+ NF  SWKDGL F ALIH+HRP+LID+ KL+  +   
Sbjct: 173 RSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSNARH 232

Query: 204 NLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRIC 263
           NL  AF+VAE+ L I  +LD ED+  T  PDEK+I+TYV +FYH FS  +       R+ 
Sbjct: 233 NLEHAFNVAERQLGIIPLLDPEDVF-TENPDEKSIITYVVAFYHYFSKMKVLAVEGKRVG 291

Query: 264 KVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLH 323
           KV+    E E+++E Y  LASDLL WI +TI  L +R   N++  +QQ+L+ F  YR + 
Sbjct: 292 KVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVE 351

Query: 324 KPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLL 383
           KPPK QEK  LE+   T+Q+++R +N+  + P +G++VSDIN AW  LE+ E   E  L 
Sbjct: 352 KPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALR 411

Query: 384 NEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESD 443
           NE+ R E+L+ LA +F +KA++ E W    + ++ Q ++    L+ ++A  KKHEA E+D
Sbjct: 412 NELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNF-GYDLAAVEAAKKKHEAIETD 470

Query: 444 LAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKL 503
            AA+++RV  +  +AQEL + +Y+D   + AR   I   W  L  L Q RR+ LE T  L
Sbjct: 471 TAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLAL 530

Query: 504 LETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADK 563
            +    +            +WM+     L        + E++ L   H+     L +AD 
Sbjct: 531 QKLFQDMLHSI--------DWMDEIKAHLLSAEFGKHLLEVEDLLQKHK-----LMEAD- 576

Query: 564 ERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHA 623
                + I  +  K +    +       Y    PQ I  +  H+ Q             A
Sbjct: 577 -----IAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKA 631

Query: 624 RQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISI--EMHGTLEDQLSHLRQYEKSIVNY 681
           + + ++RL K F  + +    WI+ K +    +    ++   L  Q  H + +E  +   
Sbjct: 632 QLEQSKRLWKFFW-EMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKH-KAFEDELRGL 689

Query: 682 KPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIA---RTINEVEN 733
              ++Q+  +   +     F +      ++ +   W+QL    A   + + + EN
Sbjct: 690 DAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAEN 744



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 90/467 (19%), Positives = 177/467 (37%), Gaps = 54/467 (11%)

Query: 280 EKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFN 339
           +KL  D+L     +I W++            + L +  D  + HK  +     Q +    
Sbjct: 531 QKLFQDMLH----SIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKA 586

Query: 340 TLQTKLRLSNRPAFMPSEGRMVSD-INNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEK 398
                L+ +    + P + +++ D I++   C E++             +LE+   L  K
Sbjct: 587 ITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSN----MAAGRKAQLEQSKRLW-K 641

Query: 399 FRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIA 458
           F  +    E+W   KE +    DY    L+ +  L +KH+AFE +L      +EQI   A
Sbjct: 642 FFWEMDEAESWIKEKEQIYSSLDYGK-DLTSVLILQRKHKAFEDELRGLDAHLEQIFQEA 700

Query: 459 QELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRA 518
             +     +  P + AR +++  QWD L  L    ++ L+  E         + ++   A
Sbjct: 701 HGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAEN--------FFQFQGDA 752

Query: 519 APFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKI 578
                W++ A   L    +       + L   H+ F   L + ++ R    G+   + + 
Sbjct: 753 DDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDF---LEELEESR----GVMEHLEQQ 805

Query: 579 VQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRD---QALTEEHARQQHNER---LR 632
            Q +              P+E     D   +L   R+   Q + +   RQQ  +    L 
Sbjct: 806 AQGF--------------PEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLY 851

Query: 633 KQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDH 692
             FG + +    W+  K + +    +EM  TLED      +++      K  + Q++G +
Sbjct: 852 TVFG-ETDACELWMGEKEKWLA--EMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVN 908

Query: 693 QLIQEALIFD----NKHTNYTMEHIRVGWEQLLTTIARTINEVENQI 735
            L   +L+      ++      +H+   W+   T ++     V++ +
Sbjct: 909 -LAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSAL 954



 Score = 50.8 bits (120), Expect = 5e-06
 Identities = 71/331 (21%), Positives = 138/331 (41%), Gaps = 39/331 (11%)

Query: 398  KFRQKASIHEAWTDGKEAMLRQKDY---ETATLSEIKALLKKHEAFESDLAAHQDRVEQI 454
            +F+  A   +AW      +L  +D    E AT    +AL KKH+ F  +L   +  +E +
Sbjct: 747  QFQGDADDLKAWLQDAHRLLSGEDVGQDEGAT----RALGKKHKDFLEELEESRGVMEHL 802

Query: 455  AAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEY 514
               AQ   E ++ DSP V  R Q + + +  + A    R++ L+      E +D LY  +
Sbjct: 803  EQQAQGFPE-EFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQ------EALD-LYTVF 854

Query: 515  AKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLA--ILGIH 572
             +  A    WM    + L +  +  T+E+++ +     Q +  + D + + L   I G++
Sbjct: 855  GETDA-CELWMGEKEKWLAEMEMPDTLEDLEVV-----QHRFDILDQEMKTLMTQIDGVN 908

Query: 573  NEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLR 632
               + +V++ H        Y       +N +W   + LV  R +A+  + A + HN    
Sbjct: 909  LAANSLVESGHPRSREVKQYQ----DHLNTRWQAFQTLVSERREAV--DSALRVHN---- 958

Query: 633  KQFGAQANVIGPWIQTK---MEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLE 689
              +         WI  K   +E    +  ++ G +  Q   L   E+ +   + ++D LE
Sbjct: 959  --YCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRK-LSGLERDVAAIQARVDALE 1015

Query: 690  GDHQLIQEALIFDNKHTNYTMEHIRVGWEQL 720
             + Q + ++     +      +H+   W+ L
Sbjct: 1016 RESQQLMDSHPEQKEDIGQRQKHLEELWQGL 1046



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 58/272 (21%), Positives = 105/272 (38%), Gaps = 45/272 (16%)

Query: 268  VNQENEQLMED---YEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHK 324
            ++ E +QLM++   +  L S  LE + R    L+    E T H    +  D R       
Sbjct: 1332 IDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLR------- 1384

Query: 325  PPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLE-----------Q 373
               +Q    L    + ++ +LR  +    + S  RM++ +      +            Q
Sbjct: 1385 ---LQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQ 1441

Query: 374  V----EKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEA------------WTDGKEAML 417
            V    E+G +  L  E R L+ L+ L  + +Q  S                W + +  + 
Sbjct: 1442 VPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLA 1501

Query: 418  RQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQ 477
            +  DY T  L  ++  +KK++  ++++  H  RVE +    Q+L E    D   +  R  
Sbjct: 1502 QSADYGT-NLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLG 1560

Query: 478  KICDQWDNL----GALTQKRREALERTEKLLE 505
             +   WD L        Q+ R+A E  +  L+
Sbjct: 1561 HLQSSWDRLREAAAGRLQRLRDANEAQQYYLD 1592



 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 66/269 (24%), Positives = 107/269 (39%), Gaps = 36/269 (13%)

Query: 248  AFSGAQKAETAANRICKVLAVNQ--------ENEQLMEDYEK-----LASDLLEWIRRTI 294
            A++G +KAE   N+  +V A  Q           QL++  +K     +A DLL W+   I
Sbjct: 1865 AYAG-EKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESII 1923

Query: 295  PWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFM 354
              +E +             E  RD   +    K  +    EI   +      L    + +
Sbjct: 1924 RQIETQ-------------ERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLL 1970

Query: 355  PSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAE--KFRQKASIHEAWTDG 412
              + +   +I      L+QV    +E       R ERL  L E  +F + AS+ EAW   
Sbjct: 1971 QRQHQASEEIREK---LQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIA 2027

Query: 413  KEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQI-AAIAQELNELDYYDSPS 471
            +E  L   D+   T+  ++ L+K+HEAFE   A+  +R   +      EL E    + P+
Sbjct: 2028 QEPYLASGDFGH-TVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELKERQIAERPA 2086

Query: 472  VNARCQKICDQWDNLGALTQKRREALERT 500
                 Q+  ++ +  G        A ERT
Sbjct: 2087 EETGPQE--EEGETAGEAPVSHHAATERT 2113



 Score = 38.5 bits (88), Expect = 0.028
 Identities = 35/135 (25%), Positives = 59/135 (43%), Gaps = 11/135 (8%)

Query: 397  EKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAA 456
            + F Q       W + K    +   Y+ A     K L  KH+AF ++LA+H+  +E I A
Sbjct: 1277 QNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWL--KHQAFVAELASHEGWLENIDA 1334

Query: 457  IAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAK 516
              ++L +     +  V+ + + +   WD L A T+++ + L            L L+   
Sbjct: 1335 EGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARS-----SDLRLQ--- 1386

Query: 517  RAAPFNNWMEGAMED 531
              A  N W+  AMED
Sbjct: 1387 THADLNKWI-SAMED 1400



 Score = 37.4 bits (85), Expect = 0.063
 Identities = 59/311 (18%), Positives = 120/311 (38%), Gaps = 50/311 (16%)

Query: 409  WTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYD 468
            W   K  ++         L+ I A+ +K    E D+AA Q RV+ +   +Q+L +     
Sbjct: 969  WITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQ 1028

Query: 469  SPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGA 528
               +  R + + + W  L       +++L+  E LL  + QL               +  
Sbjct: 1029 KEDIGQRQKHLEELWQGL-------QQSLQGQEDLLGEVSQL---------------QAF 1066

Query: 529  MEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYH----- 583
            ++DL D         I     A E    +LP+A++      GI +E+     +Y      
Sbjct: 1067 LQDLDD---FQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKES 1123

Query: 584  ---VNMAGTNPYTTITPQEING---KWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGA 637
               V    T+P   +  Q + G    W+ + ++   R   L +    Q+  +  ++    
Sbjct: 1124 GEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAI 1183

Query: 638  QANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEK---SIVNYKPKI-DQLEGDHQ 693
             +N          +E     +E   +LE   + +R++E    S+ N + K+   ++  ++
Sbjct: 1184 LSN----------QEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNK 1233

Query: 694  LIQEALIFDNK 704
            L+ E  ++ +K
Sbjct: 1234 LVAEGNLYSDK 1244



 Score = 36.2 bits (82), Expect = 0.14
 Identities = 33/173 (19%), Positives = 74/173 (42%), Gaps = 16/173 (9%)

Query: 387  RRLERLDHLAEKFRQKASIHE--AWTDGKEAMLRQKDYETAT--LSEIKALLKKHEAFES 442
            RR + +D  A+KFR  +   +  +W    E+++RQ + +     +S ++ L+K H+   +
Sbjct: 1895 RRTQLVD-TADKFRFFSMARDLLSWM---ESIIRQIETQERPRDVSSVELLMKYHQGINA 1950

Query: 443  DLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEK 502
            ++            + + L +  +  S  +  + Q++  +   +    +K     ER   
Sbjct: 1951 EIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMN---EKWEARWERLRM 2007

Query: 503  LLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFK 555
            LLE       ++++ A+    W+      L      HT++ ++ L   HE F+
Sbjct: 2008 LLEVC-----QFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFE 2055


>gi|67782319 spectrin beta isoform b [Homo sapiens]
          Length = 2137

 Score =  431 bits (1107), Expect = e-120
 Identities = 260/715 (36%), Positives = 390/715 (54%), Gaps = 34/715 (4%)

Query: 30  EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHK 89
           E  Q+KTFT W NSHL +   +I ++ +D RDG  L+ LLEV+SGE L KP +GKMR+H 
Sbjct: 53  EVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMRIHC 112

Query: 90  ISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISV------EE 143
           + NV+KAL F+  + V L ++G+ +IVDGN ++ LG+IWTIILRF IQDI V      E 
Sbjct: 113 LENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEGRET 172

Query: 144 TSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLT 203
            SAK+ LLLWCQ KTA Y +VN+ NF  SWKDGL F ALIH+HRP+LID+ KL+  +   
Sbjct: 173 RSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSNARH 232

Query: 204 NLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRIC 263
           NL  AF+VAE+ L I  +LD ED+  T  PDEK+I+TYV +FYH FS  +       R+ 
Sbjct: 233 NLEHAFNVAERQLGIIPLLDPEDVF-TENPDEKSIITYVVAFYHYFSKMKVLAVEGKRVG 291

Query: 264 KVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLH 323
           KV+    E E+++E Y  LASDLL WI +TI  L +R   N++  +QQ+L+ F  YR + 
Sbjct: 292 KVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVE 351

Query: 324 KPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLL 383
           KPPK QEK  LE+   T+Q+++R +N+  + P +G++VSDIN AW  LE+ E   E  L 
Sbjct: 352 KPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALR 411

Query: 384 NEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESD 443
           NE+ R E+L+ LA +F +KA++ E W    + ++ Q ++    L+ ++A  KKHEA E+D
Sbjct: 412 NELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNF-GYDLAAVEAAKKKHEAIETD 470

Query: 444 LAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKL 503
            AA+++RV  +  +AQEL + +Y+D   + AR   I   W  L  L Q RR+ LE T  L
Sbjct: 471 TAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLAL 530

Query: 504 LETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADK 563
            +    +            +WM+     L        + E++ L   H+     L +AD 
Sbjct: 531 QKLFQDMLHSI--------DWMDEIKAHLLSAEFGKHLLEVEDLLQKHK-----LMEAD- 576

Query: 564 ERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHA 623
                + I  +  K +    +       Y    PQ I  +  H+ Q             A
Sbjct: 577 -----IAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKA 631

Query: 624 RQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISI--EMHGTLEDQLSHLRQYEKSIVNY 681
           + + ++RL K F  + +    WI+ K +    +    ++   L  Q  H + +E  +   
Sbjct: 632 QLEQSKRLWKFFW-EMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKH-KAFEDELRGL 689

Query: 682 KPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIA---RTINEVEN 733
              ++Q+  +   +     F +      ++ +   W+QL    A   + + + EN
Sbjct: 690 DAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAEN 744



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 90/467 (19%), Positives = 177/467 (37%), Gaps = 54/467 (11%)

Query: 280 EKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFN 339
           +KL  D+L     +I W++            + L +  D  + HK  +     Q +    
Sbjct: 531 QKLFQDMLH----SIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKA 586

Query: 340 TLQTKLRLSNRPAFMPSEGRMVSD-INNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEK 398
                L+ +    + P + +++ D I++   C E++             +LE+   L  K
Sbjct: 587 ITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSN----MAAGRKAQLEQSKRLW-K 641

Query: 399 FRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIA 458
           F  +    E+W   KE +    DY    L+ +  L +KH+AFE +L      +EQI   A
Sbjct: 642 FFWEMDEAESWIKEKEQIYSSLDYGK-DLTSVLILQRKHKAFEDELRGLDAHLEQIFQEA 700

Query: 459 QELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRA 518
             +     +  P + AR +++  QWD L  L    ++ L+  E         + ++   A
Sbjct: 701 HGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAEN--------FFQFQGDA 752

Query: 519 APFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKI 578
                W++ A   L    +       + L   H+ F   L + ++ R    G+   + + 
Sbjct: 753 DDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDF---LEELEESR----GVMEHLEQQ 805

Query: 579 VQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRD---QALTEEHARQQHNER---LR 632
            Q +              P+E     D   +L   R+   Q + +   RQQ  +    L 
Sbjct: 806 AQGF--------------PEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLY 851

Query: 633 KQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDH 692
             FG + +    W+  K + +    +EM  TLED      +++      K  + Q++G +
Sbjct: 852 TVFG-ETDACELWMGEKEKWLA--EMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVN 908

Query: 693 QLIQEALIFD----NKHTNYTMEHIRVGWEQLLTTIARTINEVENQI 735
            L   +L+      ++      +H+   W+   T ++     V++ +
Sbjct: 909 -LAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSAL 954



 Score = 50.8 bits (120), Expect = 5e-06
 Identities = 71/331 (21%), Positives = 138/331 (41%), Gaps = 39/331 (11%)

Query: 398  KFRQKASIHEAWTDGKEAMLRQKDY---ETATLSEIKALLKKHEAFESDLAAHQDRVEQI 454
            +F+  A   +AW      +L  +D    E AT    +AL KKH+ F  +L   +  +E +
Sbjct: 747  QFQGDADDLKAWLQDAHRLLSGEDVGQDEGAT----RALGKKHKDFLEELEESRGVMEHL 802

Query: 455  AAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEY 514
               AQ   E ++ DSP V  R Q + + +  + A    R++ L+      E +D LY  +
Sbjct: 803  EQQAQGFPE-EFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQ------EALD-LYTVF 854

Query: 515  AKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLA--ILGIH 572
             +  A    WM    + L +  +  T+E+++ +     Q +  + D + + L   I G++
Sbjct: 855  GETDA-CELWMGEKEKWLAEMEMPDTLEDLEVV-----QHRFDILDQEMKTLMTQIDGVN 908

Query: 573  NEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLR 632
               + +V++ H        Y       +N +W   + LV  R +A+  + A + HN    
Sbjct: 909  LAANSLVESGHPRSREVKQYQ----DHLNTRWQAFQTLVSERREAV--DSALRVHN---- 958

Query: 633  KQFGAQANVIGPWIQTK---MEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLE 689
              +         WI  K   +E    +  ++ G +  Q   L   E+ +   + ++D LE
Sbjct: 959  --YCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRK-LSGLERDVAAIQARVDALE 1015

Query: 690  GDHQLIQEALIFDNKHTNYTMEHIRVGWEQL 720
             + Q + ++     +      +H+   W+ L
Sbjct: 1016 RESQQLMDSHPEQKEDIGQRQKHLEELWQGL 1046



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 58/272 (21%), Positives = 105/272 (38%), Gaps = 45/272 (16%)

Query: 268  VNQENEQLMED---YEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHK 324
            ++ E +QLM++   +  L S  LE + R    L+    E T H    +  D R       
Sbjct: 1332 IDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLR------- 1384

Query: 325  PPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLE-----------Q 373
               +Q    L    + ++ +LR  +    + S  RM++ +      +            Q
Sbjct: 1385 ---LQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQ 1441

Query: 374  V----EKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEA------------WTDGKEAML 417
            V    E+G +  L  E R L+ L+ L  + +Q  S                W + +  + 
Sbjct: 1442 VPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLA 1501

Query: 418  RQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQ 477
            +  DY T  L  ++  +KK++  ++++  H  RVE +    Q+L E    D   +  R  
Sbjct: 1502 QSADYGT-NLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLG 1560

Query: 478  KICDQWDNL----GALTQKRREALERTEKLLE 505
             +   WD L        Q+ R+A E  +  L+
Sbjct: 1561 HLQSSWDRLREAAAGRLQRLRDANEAQQYYLD 1592



 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 66/269 (24%), Positives = 107/269 (39%), Gaps = 36/269 (13%)

Query: 248  AFSGAQKAETAANRICKVLAVNQ--------ENEQLMEDYEK-----LASDLLEWIRRTI 294
            A++G +KAE   N+  +V A  Q           QL++  +K     +A DLL W+   I
Sbjct: 1865 AYAG-EKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESII 1923

Query: 295  PWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFM 354
              +E +             E  RD   +    K  +    EI   +      L    + +
Sbjct: 1924 RQIETQ-------------ERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLL 1970

Query: 355  PSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAE--KFRQKASIHEAWTDG 412
              + +   +I      L+QV    +E       R ERL  L E  +F + AS+ EAW   
Sbjct: 1971 QRQHQASEEIREK---LQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIA 2027

Query: 413  KEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQI-AAIAQELNELDYYDSPS 471
            +E  L   D+   T+  ++ L+K+HEAFE   A+  +R   +      EL E    + P+
Sbjct: 2028 QEPYLASGDFGH-TVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELKERQIAERPA 2086

Query: 472  VNARCQKICDQWDNLGALTQKRREALERT 500
                 Q+  ++ +  G        A ERT
Sbjct: 2087 EETGPQE--EEGETAGEAPVSHHAATERT 2113



 Score = 38.5 bits (88), Expect = 0.028
 Identities = 35/135 (25%), Positives = 59/135 (43%), Gaps = 11/135 (8%)

Query: 397  EKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAA 456
            + F Q       W + K    +   Y+ A     K L  KH+AF ++LA+H+  +E I A
Sbjct: 1277 QNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWL--KHQAFVAELASHEGWLENIDA 1334

Query: 457  IAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAK 516
              ++L +     +  V+ + + +   WD L A T+++ + L            L L+   
Sbjct: 1335 EGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARS-----SDLRLQ--- 1386

Query: 517  RAAPFNNWMEGAMED 531
              A  N W+  AMED
Sbjct: 1387 THADLNKWI-SAMED 1400



 Score = 37.4 bits (85), Expect = 0.063
 Identities = 59/311 (18%), Positives = 120/311 (38%), Gaps = 50/311 (16%)

Query: 409  WTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYD 468
            W   K  ++         L+ I A+ +K    E D+AA Q RV+ +   +Q+L +     
Sbjct: 969  WITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQ 1028

Query: 469  SPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGA 528
               +  R + + + W  L       +++L+  E LL  + QL               +  
Sbjct: 1029 KEDIGQRQKHLEELWQGL-------QQSLQGQEDLLGEVSQL---------------QAF 1066

Query: 529  MEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYH----- 583
            ++DL D         I     A E    +LP+A++      GI +E+     +Y      
Sbjct: 1067 LQDLDD---FQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKES 1123

Query: 584  ---VNMAGTNPYTTITPQEING---KWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGA 637
               V    T+P   +  Q + G    W+ + ++   R   L +    Q+  +  ++    
Sbjct: 1124 GEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAI 1183

Query: 638  QANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEK---SIVNYKPKI-DQLEGDHQ 693
             +N          +E     +E   +LE   + +R++E    S+ N + K+   ++  ++
Sbjct: 1184 LSN----------QEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNK 1233

Query: 694  LIQEALIFDNK 704
            L+ E  ++ +K
Sbjct: 1234 LVAEGNLYSDK 1244



 Score = 36.2 bits (82), Expect = 0.14
 Identities = 33/173 (19%), Positives = 74/173 (42%), Gaps = 16/173 (9%)

Query: 387  RRLERLDHLAEKFRQKASIHE--AWTDGKEAMLRQKDYETAT--LSEIKALLKKHEAFES 442
            RR + +D  A+KFR  +   +  +W    E+++RQ + +     +S ++ L+K H+   +
Sbjct: 1895 RRTQLVD-TADKFRFFSMARDLLSWM---ESIIRQIETQERPRDVSSVELLMKYHQGINA 1950

Query: 443  DLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEK 502
            ++            + + L +  +  S  +  + Q++  +   +    +K     ER   
Sbjct: 1951 EIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMN---EKWEARWERLRM 2007

Query: 503  LLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFK 555
            LLE       ++++ A+    W+      L      HT++ ++ L   HE F+
Sbjct: 2008 LLEVC-----QFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFE 2055


>gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens]
          Length = 2390

 Score =  427 bits (1098), Expect = e-119
 Identities = 236/572 (41%), Positives = 343/572 (59%), Gaps = 30/572 (5%)

Query: 6   SQQTNDYMQPEEDWDRDLLLDPAWEKQ------------QRKTFTAWCNSHLRKAGTQIE 53
           S   N +  P+ DWD D      +E+             Q+KTFT W NSHL +   ++ 
Sbjct: 20  SDINNRWDLPDSDWDNDSSSARLFERSRIKALADEREAVQKKTFTKWVNSHLARVTCRVG 79

Query: 54  NIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAE 113
           ++  D RDG  L+ LLEV+SGE L KP +G+MR+H + NV+KAL F+  + V L ++G+ 
Sbjct: 80  DLYSDLRDGRNLLRLLEVLSGEILPKPTKGRMRIHCLENVDKALQFLKEQKVHLENMGSH 139

Query: 114 EIVDGNVKMTLGMIWTIILRFAIQDISVE------ETSAKEGLLLWCQRKTAPYKNVNIQ 167
           +IVDGN ++TLG++WTIILRF IQDISVE      + SAK+ LLLWCQ KTA Y NVN+ 
Sbjct: 140 DIVDGNHRLTLGLVWTIILRFQIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNVH 199

Query: 168 NFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDI 227
           NF  SW+DGL F A++H+HRP+L+D+  L+K +   NL  AF++AEK L + K+LD ED 
Sbjct: 200 NFTTSWRDGLAFNAIVHKHRPDLLDFESLKKCNAHYNLQNAFNLAEKELGLTKLLDPED- 258

Query: 228 VGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLL 287
           V   +PDEK+I+TYV+++YH FS  +       RI KVL    E E+L+E YE LAS+LL
Sbjct: 259 VNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDHAMEAERLVEKYESLASELL 318

Query: 288 EWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRL 347
           +WI +TI  L +R   N++  +Q +L+ F  YR + KPPK  EK  LE+   T+Q+KLR 
Sbjct: 319 QWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRA 378

Query: 348 SNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHE 407
           +N+  + P EGR++SDIN AW  LE+ E   E  L  E+ R E+L+ LA +F +KA++ E
Sbjct: 379 NNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRE 438

Query: 408 AWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYY 467
            W    + ++ Q ++    L+ ++A ++KHEA E+D+ A+  RV+ + A+A EL    Y+
Sbjct: 439 TWLSENQRLVSQDNF-GLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYH 497

Query: 468 DSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETI-DQLYLEYAKRAAPFNNWME 526
           D   + AR   +   WD L  +   RRE L    +L +   D LYL          +WME
Sbjct: 498 DIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYL---------MDWME 548

Query: 527 GAMEDLQDTFIVHTIEEIQGLTTAHEQFKATL 558
                LQ   +   +  ++ L   HE  +A +
Sbjct: 549 EMKGRLQSQDLGRHLAGVEDLLQLHELVEADI 580



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 96/465 (20%), Positives = 180/465 (38%), Gaps = 60/465 (12%)

Query: 263  CKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRL 322
            C+ L  ++E  Q   D E             I W+  R+P      M   +E  +D   +
Sbjct: 1481 CRRLQASREQHQFHRDVED-----------EILWVTERLP------MASSMEHGKDLPSV 1523

Query: 323  HKPPKVQEKCQLEINFNTLQ-TKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEW 381
                K  +  Q EI  +  +   LR   R     + G  ++++   W  L     G+E  
Sbjct: 1524 QLLMKKNQTLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKRL-----GHELE 1578

Query: 382  LLNEIRRLERLDHL-AEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAF 440
            L    +RLE  D L A++F + A+  EAW   +E  +  ++     LS  +A +KKH+  
Sbjct: 1579 LRG--KRLE--DALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSA-QAEVKKHQVL 1633

Query: 441  ESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERT 500
            E  LA +   + Q+AA +Q++ + ++ +S  ++ R  ++   +  L  L  +RRE L+  
Sbjct: 1634 EQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEH 1693

Query: 501  EKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPD 560
             +L +   +L             W++          +    E +  L     +F      
Sbjct: 1694 LRLCQLRREL--------DDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTST 1745

Query: 561  ADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTE 620
              +ER+     +   + ++   H   A    +       +N  W  + +L+  R Q L  
Sbjct: 1746 IGQERVD--SANALANGLIAGGHAARATVAEWK----DSLNEAWADLLELLDTRGQVLAA 1799

Query: 621  EHARQQHNERLRKQFGAQANVIGPWIQTKMEEI----GRISIEMHGTLEDQLSHLRQYEK 676
             +  Q+     R+            +Q K +++    GR   +++     Q  H   YE 
Sbjct: 1800 AYELQRFLHGARQALAR--------VQHKQQQLPDGTGR---DLNAAEALQRRHCA-YEH 1847

Query: 677  SIVNYKPKIDQLEGDHQLIQEALIFDN-KHTNYTMEHIRVGWEQL 720
             I    P++ Q++ D   +Q+A   D  +     M+ +   W QL
Sbjct: 1848 DIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQL 1892



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 80/426 (18%), Positives = 158/426 (37%), Gaps = 61/426 (14%)

Query: 296  WLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQ-LEINFNTLQTKLRLSNRPAFM 354
            W+E +       A+ ++LED            VQ++ + LE   NTL  ++   N  A  
Sbjct: 867  WVEEKEQWLNGLALPERLEDLE---------VVQQRFETLEPEMNTLAAQITAVNDIAEQ 917

Query: 355  ------PSEGRMVS---DINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASI 405
                  P + R+V+    +N+ W    ++  G +  L + +          + +  + + 
Sbjct: 918  LLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALS--------IQNYHLECTE 969

Query: 406  HEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELD 465
             +AW   K  ++         L+ + AL +K    E DL A   RV ++   A  L    
Sbjct: 970  TQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGH 1029

Query: 466  YYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWM 525
               + ++NAR +++   W++L A  ++R E+L    +L         ++ +    F  W+
Sbjct: 1030 PAQAVAINARLREVQTGWEDLRATMRRREESLGEARRL--------QDFLRSLDDFQAWL 1081

Query: 526  EGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVN 585
                  +       T+ E + L   H   +  +  A  E   +  +  EV++        
Sbjct: 1082 GRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTR-------- 1133

Query: 586  MAGTNPYTTITPQEING---KWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVI 642
                +P      Q +      W+ + ++   R   L + H  Q      R+  G  ++  
Sbjct: 1134 -DQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSS-- 1190

Query: 643  GPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQ----LEGDHQLIQEA 698
                    +E      EM GTL+   + +++ E  +       ++    LE   QL+ E 
Sbjct: 1191 --------QEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEG 1242

Query: 699  LIFDNK 704
             I  +K
Sbjct: 1243 NIHADK 1248



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 82/436 (18%), Positives = 158/436 (36%), Gaps = 60/436 (13%)

Query: 264 KVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLH 323
           +++A  +E   L  + +K+  DLL      + W+E          + + L    D  +LH
Sbjct: 518 QMVAARRERLLLNLELQKVFQDLLY----LMDWMEEMKGRLQSQDLGRHLAGVEDLLQLH 573

Query: 324 KPPKVQEKCQLEINFNTLQTKLRLSNR-PAFMPSEGRMVSDINNAWGCLEQVEKGYEEWL 382
           +  +     Q E       + LR  N    + P + ++VS+       + ++E+ YE   
Sbjct: 574 ELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSER------VAKLEQSYEALC 627

Query: 383 LNEIRRLERLDHLAE--KFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAF 440
                R  RL+      +F  +    EAW   ++ +L   D        ++ LL KH A 
Sbjct: 628 ELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALR-LLNKHTAL 686

Query: 441 ESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERT 500
             +++     ++      Q+L    +  +   +AR  ++  QW+ L AL ++R + L + 
Sbjct: 687 RGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQA 746

Query: 501 EKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAH----EQFKA 556
             L         ++   A     W+  A+  +    + H     Q L   H    E+ ++
Sbjct: 747 ASL--------YQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRS 798

Query: 557 TLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWD----HVRQLVP 612
             P  D  R                     A   P T     E+ G+      H  +L  
Sbjct: 799 HRPTLDALR-------------------EQAAALPPTLSRTPEVQGRVPTLERHYEEL-- 837

Query: 613 RRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLR 672
              QA   E AR            ++A   G W++ K + +  ++      L ++L  L 
Sbjct: 838 ---QARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLA------LPERLEDLE 888

Query: 673 QYEKSIVNYKPKIDQL 688
             ++     +P+++ L
Sbjct: 889 VVQQRFETLEPEMNTL 904



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 95/442 (21%), Positives = 162/442 (36%), Gaps = 61/442 (13%)

Query: 350  RPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAW 409
            +P         + D++  W  LE   +     L +  R        AE F Q     E+W
Sbjct: 1347 KPELKALVSEKLRDLHRRWDELETTTQAKARSLFDANR--------AELFAQSCCALESW 1398

Query: 410  TDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDS 469
             +  +A L   DY    L+ +  LLKK +  E ++A  +  VE I A A+ L + D    
Sbjct: 1399 LESLQAQLHSDDY-GKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQED--QG 1455

Query: 470  PSVNARCQKICDQWDNLGALTQKRREALERTEKLLE------TIDQLYLEYAKRAAPFNN 523
                 R  +  +  +   AL Q  RE   R +   E       ++   L   +R  P  +
Sbjct: 1456 AGEVERTSRAVE--EKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTER-LPMAS 1512

Query: 524  WMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYH 583
             ME   +      ++   + +Q     HE   A L    +ER   LG      ++ +   
Sbjct: 1513 SMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADL----RERQRALGAAAAGPELAELQE 1568

Query: 584  V-NMAGTNPYTTITPQEINGK--WDHVRQLVPRRDQA-----LTEEHARQQHNERLRKQF 635
            +    G          E+ GK   D +R     RD A     + E+       E+ + + 
Sbjct: 1569 MWKRLGHE-------LELRGKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDEL 1621

Query: 636  GAQANVIGPWI-QTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQL-EGDHQ 693
             AQA V    + +  + +  +   ++  + +D + H       I   + ++D+L  G  +
Sbjct: 1622 SAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKE 1681

Query: 694  LIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEF-- 751
            L  E             EH+R      L  + R ++++E  I  R+    S E   ++  
Sbjct: 1682 LAGE-------RRERLQEHLR------LCQLRRELDDLEQWIQEREVVAASHELGQDYEH 1728

Query: 752  ----RASFNHFDRDHSGTLGPE 769
                R  F  F RD S T+G E
Sbjct: 1729 VTMLRDKFREFSRDTS-TIGQE 1749



 Score = 39.3 bits (90), Expect = 0.016
 Identities = 20/68 (29%), Positives = 40/68 (58%), Gaps = 4/68 (5%)

Query: 399  FRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDR---VEQIA 455
            F + A + EAW   +E ++R  +    T+ E+++L+K+HEAF+    A ++R   +E++ 
Sbjct: 2018 FGRDAGMAEAWLCSQEPLVRSAELG-CTVDEVESLIKRHEAFQKSAVAWEERFCALEKLT 2076

Query: 456  AIAQELNE 463
            A+ +   E
Sbjct: 2077 ALEEREKE 2084



 Score = 37.7 bits (86), Expect = 0.048
 Identities = 35/143 (24%), Positives = 65/143 (45%), Gaps = 4/143 (2%)

Query: 356  SEGRMVSD-INNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKE 414
            SEG + +D I      +E+  K  ++     + RL R +   + F Q     + W D  E
Sbjct: 1240 SEGNIHADKIREKADSIERRHKKNQDAAQQFLGRL-RDNREQQHFLQDCHELKLWID--E 1296

Query: 415  AMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNA 474
             ML  +D        +    +KH+AF ++LAA++D ++++    +EL          V+ 
Sbjct: 1297 KMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSE 1356

Query: 475  RCQKICDQWDNLGALTQKRREAL 497
            + + +  +WD L   TQ +  +L
Sbjct: 1357 KLRDLHRRWDELETTTQAKARSL 1379



 Score = 35.0 bits (79), Expect = 0.31
 Identities = 41/228 (17%), Positives = 85/228 (37%), Gaps = 20/228 (8%)

Query: 508 DQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPD---ADKE 564
           ++L  +Y   A+    W+E  +  L D  + +++  +Q    +   ++         +K 
Sbjct: 304 ERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKG 363

Query: 565 RLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQE------INGKWDHVRQLVPRRDQAL 618
            L +L +    SK+           N     TP+E      IN  W+ + +    R+ AL
Sbjct: 364 NLEVL-LFTIQSKL---------RANNQKVYTPREGRLISDINKAWERLEKAEHERELAL 413

Query: 619 TEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMH-GTLEDQLSHLRQYEKS 677
             E  RQ+  E+L  +F  +A +   W+      + + +  +    +E  +      E  
Sbjct: 414 RTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETD 473

Query: 678 IVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIA 725
           IV Y  ++  ++     +      D K       ++   W+ L   +A
Sbjct: 474 IVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVA 521



 Score = 31.6 bits (70), Expect = 3.4
 Identities = 20/78 (25%), Positives = 39/78 (50%), Gaps = 2/78 (2%)

Query: 427  LSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYD-SPSVNARCQKICDQWDN 485
            L+  +AL ++H A+E D+ A   +V+Q+      L +    D +  +    Q + + W  
Sbjct: 1832 LNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQ 1891

Query: 486  L-GALTQKRREALERTEK 502
            L G+   +R+  L+ T+K
Sbjct: 1892 LQGSSAARRQLLLDTTDK 1909


>gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1
           [Homo sapiens]
          Length = 2564

 Score =  405 bits (1042), Expect = e-113
 Identities = 221/487 (45%), Positives = 310/487 (63%), Gaps = 8/487 (1%)

Query: 30  EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHK 89
           E  Q+KTFT W NSHL + G  I ++  D RDG  L  LLEV+SGE+L +P RG+MR+H 
Sbjct: 60  EAVQKKTFTKWVNSHLARVGCHIGDLYVDLRDGFVLTRLLEVLSGEQLPRPTRGRMRIHS 119

Query: 90  ISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVE-----ET 144
           + NV+KAL F+  + V L ++G+ +IVDGN ++TLG++WTIILRF IQ I +E     ET
Sbjct: 120 LENVDKALQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWTIILRFQIQVIKIETEDNRET 179

Query: 145 -SAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLT 203
            SAK+ LLLWCQ KTA Y  VNIQNF  SW+DGL F ALIHRHRP+L+D+ KL K +   
Sbjct: 180 RSAKDALLLWCQMKTAGYPEVNIQNFTTSWRDGLAFNALIHRHRPDLVDFSKLTKSNANY 239

Query: 204 NLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRIC 263
           NL  AF  AE++L + ++LD ED V    PDEK+I+TYV SFYH FS  +       RI 
Sbjct: 240 NLQRAFRTAEQHLGLARLLDPED-VNMEAPDEKSIITYVVSFYHYFSKMKALAVEGKRIG 298

Query: 264 KVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLH 323
           KVL    E  +++E YE+LA++LL WI RT+  + N+   N++  +QQ+L+ F  Y  L 
Sbjct: 299 KVLDQVLEVGKIIERYEELAAELLAWIHRTVGLISNQKFANSLSGVQQQLQAFTAYCTLE 358

Query: 324 KPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLL 383
           KP K QEK  LE+   ++Q+KLR  NR  F+P EG  + DI+ AWG LE+ E   E  L 
Sbjct: 359 KPVKFQEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHEREAALR 418

Query: 384 NEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESD 443
            E+ R E+L+ LA++F  K ++ E+W +  + ++ Q ++    L  ++A +KKHEA E+D
Sbjct: 419 AELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNF-GYELPAVEAAMKKHEAIEAD 477

Query: 444 LAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKL 503
           +AA+++RV+ +A +AQ L    YYD   V A+   +  QW  L  L   RR  LE+   L
Sbjct: 478 IAAYEERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQWALLTGLVGARRTRLEQNLAL 537

Query: 504 LETIDQL 510
            +   ++
Sbjct: 538 QKVFQEM 544



 Score = 64.3 bits (155), Expect = 5e-10
 Identities = 96/486 (19%), Positives = 202/486 (41%), Gaps = 60/486 (12%)

Query: 253  QKAETAANRICKVLAVNQENEQLM---EDYEKLASDL---LEWIRRTIPWLENRVPENTM 306
            ++      R+ ++L   QE  +L+   ++  ++A DL   L W++  +P        N +
Sbjct: 1488 ERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGL 1547

Query: 307  HAMQQKLEDFRDYRRLHKP--PKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDI 364
             A+QQ ++  +  RR  +   P+++E  +      +L++    + R        R +  +
Sbjct: 1548 QAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVR--------RGLEQL 1599

Query: 365  NNAWGCLEQVEKGYEEWLLNEIRRLERLDHL--AEKFRQKASIHEAWTDGKEAMLRQKDY 422
             +AW  L +  +          RR + LD     E++    +  EAW   +E ++  +D 
Sbjct: 1600 QSAWAGLREAAE----------RRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDK 1649

Query: 423  ETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQ 482
                 S ++ LLKKH   E  +  +++ + Q++   + L E+ + DS  ++ R  ++   
Sbjct: 1650 GKDEQSTLQ-LLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRL 1708

Query: 483  WDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIE 542
            +  L  L ++RR ALE+   L         + +++ +   +W+           +    E
Sbjct: 1709 YVALKELGEERRVALEQQYWL--------YQLSRQVSELEHWIAEKEVVAGSPELGQDFE 1760

Query: 543  EIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEING 602
             +  L     +F +    A +ERLA   ++  V ++++  H   A    +       +N 
Sbjct: 1761 HVSVLQEKFSEFASETGMAGRERLA--AVNQMVDELIECGHTAAATMAEW----KDGLNE 1814

Query: 603  KWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISI--EM 660
             W  + +L+  R Q L    +R+ H      +F + A  +   I+ K   + R++   E 
Sbjct: 1815 AWAELLELMGTRAQLLAA--SRELH------KFFSDARELQGQIEEKRRRLPRLTTPPEP 1866

Query: 661  HGTLEDQLSHLRQYEKSIVNYKPKIDQL-EGDHQLIQEALIFDNKHTNYTM---EHIRVG 716
              +       LR +E  +     ++ QL EG  QL     ++  +H        + +  G
Sbjct: 1867 RPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQL---RTVYAGEHAEAIASREQEVLQG 1923

Query: 717  WEQLLT 722
            W++LL+
Sbjct: 1924 WKELLS 1929



 Score = 43.5 bits (101), Expect = 9e-04
 Identities = 69/318 (21%), Positives = 135/318 (42%), Gaps = 32/318 (10%)

Query: 264  KVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLH 323
            ++LA ++E  +   D  +L   + E  RR         P  +  +MQ+ L  F    +L 
Sbjct: 1828 QLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQL- 1886

Query: 324  KPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLL 383
                V +  QL+     L+T     +  A    E              ++V +G++E L 
Sbjct: 1887 ---LVSQVRQLQEGAAQLRTVYAGEHAEAIASRE--------------QEVLQGWKELLS 1929

Query: 384  N-EIRRLERLDHLAEKFRQKASIHE--AWTDGKEAMLRQKDYETATLSEIKALLKKHEAF 440
              E  RL  +   A+  R  + + +  +W DG  + +   D +   +S ++ L+  H+  
Sbjct: 1930 ACEDARLH-VSSTADALRFHSQVRDLLSWMDGIASQIGAAD-KPRDVSSVEVLMNYHQGL 1987

Query: 441  ESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERT 500
            +++L A   RV ++    QEL      +    +A   +I  Q D LG   ++  E  +R 
Sbjct: 1988 KTELEA---RVPELTT-CQELGRSLLLNK---SAMADEIQAQLDKLGTRKEEVSEKWDRH 2040

Query: 501  EKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPD 560
             + L+ + +++ ++A+ A   + W+      LQ   +  +++E++ L   HE F+     
Sbjct: 2041 WEWLQQMLEVH-QFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRKAAA- 2098

Query: 561  ADKERLAILGIHNEVSKI 578
            A +ER + L     + KI
Sbjct: 2099 AWEERFSSLRRLTTIEKI 2116



 Score = 40.0 bits (92), Expect = 0.010
 Identities = 34/126 (26%), Positives = 57/126 (45%), Gaps = 5/126 (3%)

Query: 388 RLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAH 447
           RLE+   L + F++   + + W +  +A L  ++     L E   LL+KH   E D+AA 
Sbjct: 530 RLEQNLALQKVFQEMVYMVD-WMEEMQAQLLSRECGQH-LVEADDLLQKHGLLEGDIAAQ 587

Query: 448 QDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQ---KRREALERTEKLL 504
            +RVE + A A   ++L  Y        C ++      L  L +   +RR  LE +  L 
Sbjct: 588 SERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAELQEQAARRRAELEASRSLW 647

Query: 505 ETIDQL 510
             + +L
Sbjct: 648 ALLQEL 653



 Score = 32.7 bits (73), Expect = 1.5
 Identities = 26/103 (25%), Positives = 47/103 (45%), Gaps = 4/103 (3%)

Query: 414  EAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVN 473
            E ML  +D       ++     +H+AF ++LA +++ +E+I    Q+L +     + SV 
Sbjct: 1323 EKMLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVR 1382

Query: 474  ARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAK 516
             +  +I   W  L + TQ +   L    K     DQL   +A+
Sbjct: 1383 KKLGEIRQCWAELESTTQAKARQLFEASK----ADQLVQSFAE 1421



 Score = 32.0 bits (71), Expect = 2.6
 Identities = 43/199 (21%), Positives = 77/199 (38%), Gaps = 18/199 (9%)

Query: 363  DINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDY 422
            ++   WG L    +   E  +    RL+R  H  + F       +    G E  L     
Sbjct: 1065 ELGAEWGALASAAQACGE-AVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPN--- 1120

Query: 423  ETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYD---SPSVNARCQKI 479
               +L E  ALL +H A + ++   ++   +I A ++ L   D  +     +++     +
Sbjct: 1121 ---SLEEADALLARHAALKEEVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPHL 1177

Query: 480  CDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVH 539
               W  L  L + RREAL +       I QL+L   ++A       E A+   +   +  
Sbjct: 1178 ELGWHKLLGLWEARREALVQAH-----IYQLFLRDLRQALVVLRNQEMALSGAE---LPG 1229

Query: 540  TIEEIQGLTTAHEQFKATL 558
            T+E ++     H  F  T+
Sbjct: 1230 TVESVEEALKQHRDFLTTM 1248



 Score = 31.2 bits (69), Expect = 4.5
 Identities = 26/114 (22%), Positives = 51/114 (44%), Gaps = 4/114 (3%)

Query: 386 IRRLERLDHLAEKFRQKASIH--EAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESD 443
           +RR    D LA  +R    +H  E W   KE  L       + L +++ +  + E+ + +
Sbjct: 872 LRRQWLRDALAV-YRMFGEVHACELWIGEKEQWLLSMRVPDS-LDDVEVVQHRFESLDQE 929

Query: 444 LAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREAL 497
           + +   RV  +    QEL E  +  S  V +    +  +W+ +  L ++R+E +
Sbjct: 930 MNSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEM 983


>gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens]
          Length = 3639

 Score =  344 bits (882), Expect = 2e-94
 Identities = 204/537 (37%), Positives = 307/537 (57%), Gaps = 21/537 (3%)

Query: 31  KQQRKTFTAWCNSHLR--KAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVH 88
           + Q KTFT W N+  +  +AG +I N+  +  DG+ L+ LLE+ISGE L  P RG++RVH
Sbjct: 19  QMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISGEALPPPSRGRLRVH 78

Query: 89  KISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEET---- 144
            + N ++AL F+ +K V +  IG E IVDG+  + LG+IW IILRF I  IS+++     
Sbjct: 79  FLENSSRALAFLRAK-VPVPLIGPENIVDGDQTLILGLIWVIILRFQISHISLDKEEFGA 137

Query: 145 -----SAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKD 199
                S KE LL+WCQRKTA Y NVNI +F  SW DGLGF ALIH HRP+L+DYG LR D
Sbjct: 138 SAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHAHRPDLLDYGSLRPD 197

Query: 200 DPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAA 259
            PL NL  AF VAE+ L I ++LD ED V  A+PDE++IMTYVS +YH  S   + +T  
Sbjct: 198 RPLHNLAFAFLVAEQELGIAQLLDPED-VAAAQPDERSIMTYVSLYYHYCSRLHQGQTVQ 256

Query: 260 NRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDY 319
            R+ K+L   QE E L   YE+L +DLL WI      LE R   +++ AM+Q L  F  +
Sbjct: 257 RRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIF 316

Query: 320 RRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYE 379
           R   KPP++Q++   E     LQT L+  NR  F+P EG  +++++  W  LE  E    
Sbjct: 317 RTQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCWAGLEWAEAARS 376

Query: 380 EWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEA 439
           + L   + +L+RL+ LA +F+ KA++ E++    E +L Q     A+L+ ++A +++   
Sbjct: 377 QALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGM 436

Query: 440 FESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALER 499
            E+ +   + R + +A IA  L +  Y+    V  R +++  +W  L    Q +R+ +  
Sbjct: 437 LEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVAD 496

Query: 500 TEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKA 556
            + +L  + ++       AA  ++ +E   E  + T     + E+  L   H+  +A
Sbjct: 497 MQAVLSLLQEV------EAA--SHQLEELQEPARSTACGQQLAEVVELLQRHDLLEA 545



 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 59/246 (23%), Positives = 109/246 (44%), Gaps = 39/246 (15%)

Query: 285  DLLEWIRRTI---PWLENRVPENTMHAMQQKLED-------FRDYRRLHKPPKVQEKCQL 334
            + LE+++R      W++ +  +  +  + Q LE         R++R       V + C  
Sbjct: 2221 NFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIR 2280

Query: 335  EINFNTLQTKLRLSNRPAFMPSEGRMV----SDINNAWGCLEQVEKGYEEWLLN--EIRR 388
             I+  +LQ K R        P E +++    S +NN W         Y++ L    EI  
Sbjct: 2281 SISDLSLQLKNR-------DPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHV 2333

Query: 389  LER-LDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAH 447
            L R LD++ ++ ++K ++ +A   GK+            L  ++ LL+KHE  E ++   
Sbjct: 2334 LSRELDNVTKRIQEKEALIQALDCGKD------------LESVQRLLRKHEELEREVHPI 2381

Query: 448  QDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALE---RTEKLL 504
            Q +VE +      L +     +  +  R Q++ + W  L +  QKRREAL+   + +KL 
Sbjct: 2382 QAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQ 2441

Query: 505  ETIDQL 510
              + +L
Sbjct: 2442 AMLQEL 2447



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 49/230 (21%), Positives = 92/230 (40%), Gaps = 10/230 (4%)

Query: 329  QEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRR 388
            Q + +  ++    Q +  L    AF+     +  D+      L Q  K   E L      
Sbjct: 2794 QRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTA 2853

Query: 389  LERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQ 448
            LE    L + FR  A    AW   K  +   +DY  + LS ++ L ++H+  ES++++H+
Sbjct: 2854 LEARSLLLKFFRD-ADEEMAWVQEKLPLAAAQDYGQS-LSAVRHLQEQHQNLESEMSSHE 2911

Query: 449  DRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETID 508
                 +     +L +  ++ +  V AR Q++     +L A   +RR  L++ ++  + + 
Sbjct: 2912 ALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLT 2971

Query: 509  QLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATL 558
            +L            +W+      L    + H+ E  Q L    E  K  L
Sbjct: 2972 EL--------LEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDL 3013



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 57/253 (22%), Positives = 107/253 (42%), Gaps = 24/253 (9%)

Query: 334  LEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLD 393
            LE   + LQ+ +     P +  S+  +   +    G L+QV+    E +    RR +   
Sbjct: 1013 LERRVHFLQSVVVKVEEPGYAESQP-LQGQVETLQGLLKQVQ----EQVAQRARR-QAET 1066

Query: 394  HLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQ 453
               + F Q++     W +  +A LR K+  +  ++  + LL++H+    ++   Q+R++Q
Sbjct: 1067 QARQSFLQESQQLLLWAESVQAQLRSKEV-SVDVASAQRLLREHQDLLEEIHLWQERLQQ 1125

Query: 454  IAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALE---RTEKLLETIDQL 510
            + A +Q +  LD  DS  V    + +  Q   L  L ++R++ L+     +K    +D  
Sbjct: 1126 LDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGF 1185

Query: 511  YLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILG 570
                A   A    W+   +++L +      + E   L   H +F   L      R   L 
Sbjct: 1186 TATCANHQA----WLH--LDNLGE-----DVREALSLLQQHREFGRLLSTLG-PRAEALR 1233

Query: 571  IHNEVSKIVQTYH 583
             H E  K+VQ+ H
Sbjct: 1234 AHGE--KLVQSQH 1244



 Score = 43.5 bits (101), Expect = 9e-04
 Identities = 31/121 (25%), Positives = 55/121 (45%), Gaps = 1/121 (0%)

Query: 395  LAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQI 454
            L   F Q A+  E W       L++         ++K LLK H+AFE+++ AH++ +  +
Sbjct: 2115 LMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLK-HQAFEAEVQAHEEVMTSV 2173

Query: 455  AAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEY 514
            A   + L    +  +  V+ R Q +   W++L      R + LE     LE + ++ L  
Sbjct: 2174 AKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAE 2233

Query: 515  A 515
            A
Sbjct: 2234 A 2234



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 41/175 (23%), Positives = 73/175 (41%), Gaps = 4/175 (2%)

Query: 330  EKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYE-EWLLNEIRR 388
            ++C+ E++  T    L  S     + +     SDI      LEQ     E  W  ++++ 
Sbjct: 2478 QECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQL 2537

Query: 389  LERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQ 448
             + L+   + F       E W   KE  L  +      L+ ++ LL KH+  E DL    
Sbjct: 2538 QQALE--LQLFLSSVEKMERWLCSKEDSLASEGLWDP-LAPMEPLLWKHKMLEWDLEVQA 2594

Query: 449  DRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKL 503
             ++  + A A+ L++  + ++ S   RCQ +  + + L      RR  LE   +L
Sbjct: 2595 GKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQL 2649



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 79/380 (20%), Positives = 139/380 (36%), Gaps = 37/380 (9%)

Query: 252  AQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIR---RTIPWLENRVPENTMHA 308
            AQ  E  A R+ +     +E  Q      +  S LL++ R     + W++ ++P      
Sbjct: 2826 AQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQD 2885

Query: 309  MQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAW 368
              Q L   R  +  H+  + +      +    L T  +L     F   E           
Sbjct: 2886 YGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHE---------VA 2936

Query: 369  GCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEA--WTDGKEAMLRQKDYETAT 426
              ++Q+EK          RR   L    E  +    + EA  W   +  +L  +D   + 
Sbjct: 2937 ARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSA 2996

Query: 427  LSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNL 486
                +ALL++ EA + DL A   R+E++   A  L      +SP V A+ Q + +     
Sbjct: 2997 -EATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVRE----- 3050

Query: 487  GALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWM--EGAMEDLQDTFIVHTIEEI 544
             A  +  R A  R   L E +    LE  +     + W+  + A  + QD       +++
Sbjct: 3051 -AHAELLRRAEARGHGLQEQLQLHQLE--RETLLLDAWLTTKAATAESQDYG-----QDL 3102

Query: 545  QGLTTAHEQFKATLPDADKERLAILGIHN--EVSKIVQTYHVNMAGTNPYTTITPQEING 602
            +G+    E+F     DA ++ +  LG      + K+  T         P+       I  
Sbjct: 3103 EGVKVLEEKF-----DAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEA 3157

Query: 603  KWDHVRQLVPRRDQALTEEH 622
             W+ + Q +  R + L   H
Sbjct: 3158 AWERLDQAIKARTENLAAAH 3177



 Score = 40.8 bits (94), Expect = 0.006
 Identities = 44/190 (23%), Positives = 81/190 (42%), Gaps = 15/190 (7%)

Query: 372  EQVEKGYEEWLL----NEIRRLERLDHLA-EKFRQKASIHEAWTDGKEAMLRQKDYETAT 426
            EQ++    +W      +E RR + L  L  ++++Q  +    W + K  M   +   +  
Sbjct: 1252 EQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEP--SGA 1309

Query: 427  LSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNL 486
               I   LK+HEA ES+L A +  VE +  + +EL          +  R Q +  +W+ L
Sbjct: 1310 RRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEAL 1369

Query: 487  GALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQG 546
                 +R + L++  +  + + QL     + A      +EGA   LQ +     +   Q 
Sbjct: 1370 NRKMTERGDELQQAGQQEQLLRQL-----QDAKEQLEQLEGA---LQSSETGQDLRSSQR 1421

Query: 547  LTTAHEQFKA 556
            L   H+Q ++
Sbjct: 1422 LQKRHQQLES 1431



 Score = 39.3 bits (90), Expect = 0.016
 Identities = 29/130 (22%), Positives = 58/130 (44%), Gaps = 8/130 (6%)

Query: 427 LSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNL 486
           L+E+  LL++H+  E+ ++AH   V  +A    EL+         + A+ + +     +L
Sbjct: 530 LAEVVELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSL 589

Query: 487 GALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQG 546
            AL + RR  LE+T +  E +     E A        W++   + + +  +   + +I G
Sbjct: 590 VALVRARRALLEQTLQRAEFLRNCEEEEA--------WLKECGQRVGNAALGRDLSQIAG 641

Query: 547 LTTAHEQFKA 556
               H+  +A
Sbjct: 642 ALQKHKALEA 651



 Score = 38.5 bits (88), Expect = 0.028
 Identities = 28/95 (29%), Positives = 47/95 (49%), Gaps = 7/95 (7%)

Query: 370  CLEQVEKGYEE----WLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETA 425
            CL+++E   +E    W L   R  E      +K RQ+    EAW    E +L + DY  +
Sbjct: 3359 CLQELEGRLQELEEAWALRWQRCAESWG--LQKLRQRLEQAEAWLACWEGLLLKPDYGHS 3416

Query: 426  TLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQE 460
             +S+++ LL +H+  E  LAA +++  Q+     E
Sbjct: 3417 -VSDVELLLHRHQDLEKLLAAQEEKFAQMQKTEME 3450



 Score = 38.1 bits (87), Expect = 0.037
 Identities = 41/182 (22%), Positives = 71/182 (39%), Gaps = 28/182 (15%)

Query: 379  EEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHE 438
            ++WL  E   L++     + F    + H+AW           D     + E  +LL++H 
Sbjct: 1166 QQWL-QEGLELQKFGREVDGFTATCANHQAWL--------HLDNLGEDVREALSLLQQHR 1216

Query: 439  AFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALE 498
             F   L+    R E + A  ++L +  +  + +V  + Q I  QW  L   +++RR  L 
Sbjct: 1217 EFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLL 1276

Query: 499  RTEKLLETIDQLYLEYAKRAAPFNNWME-----------GAMEDLQDTFIVHTIEEIQGL 547
             + +L         E+ +  A    WME           GA  ++  T   H   E + L
Sbjct: 1277 ASLQL--------QEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELL 1328

Query: 548  TT 549
             T
Sbjct: 1329 AT 1330



 Score = 38.1 bits (87), Expect = 0.037
 Identities = 48/226 (21%), Positives = 91/226 (40%), Gaps = 44/226 (19%)

Query: 314  EDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQ 373
            +D R  +RL K  +     QLE    TL  K         M +   M   +  +   LE+
Sbjct: 1414 QDLRSSQRLQKRHQ-----QLESESRTLAAK---------MAALASMAHGMAASPAILEE 1459

Query: 374  VEKGYEEWLLNEIRRLERLD-HLA------------EKFRQKASIHEAWTDGKEAMLRQK 420
             +K         +RRLE L  HLA             +F   +++  +W           
Sbjct: 1460 TQK--------HLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPT 1511

Query: 421  DYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKIC 480
             Y T  L+  ++L +KH+  + ++ AHQ +V+++ +  + L    +  +  +  +CQ++ 
Sbjct: 1512 SY-TECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELE 1570

Query: 481  DQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWME 526
              W  L    + R + L++      T  Q +L+ ++       W+E
Sbjct: 1571 GHWAELERACEARAQCLQQA----VTFQQYFLDVSE----LEGWVE 1608



 Score = 37.0 bits (84), Expect = 0.082
 Identities = 53/248 (21%), Positives = 91/248 (36%), Gaps = 24/248 (9%)

Query: 261  RICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYR 320
            R C+  A   +     + Y    S+L  W+    P + +R             ++    R
Sbjct: 1578 RACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSR---------DYGRDEAATLR 1628

Query: 321  RLHKPPKVQEKCQLEINFNTL----QTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEK 376
             ++K   +QE  +L I ++++    QT   L+     +P + R+V +       L +  +
Sbjct: 1629 LINKHQALQE--ELAIYWSSMEELDQTAQTLTGPE--VPEQQRVVQER------LREQLR 1678

Query: 377  GYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKK 436
              +E      R LE    L E  R+   + + W   ++   +  +           L  K
Sbjct: 1679 ALQELAATRDRELEGTLRLHEFLREAEDL-QGWLASQKQAAKGGESLGEDPEHALHLCTK 1737

Query: 437  HEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREA 496
               F+  +     RV     +A+ L E  +   P V  R Q +   W  L  LTQ R  A
Sbjct: 1738 FAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHA 1797

Query: 497  LERTEKLL 504
            L  TE  L
Sbjct: 1798 LRDTETTL 1805



 Score = 34.3 bits (77), Expect = 0.53
 Identities = 81/433 (18%), Positives = 165/433 (38%), Gaps = 60/433 (13%)

Query: 273  EQLMEDYEKLASDLLEWIR-RTIPWLENRVPENTMHAMQ-QKLEDFRDY--RRLHKPPKV 328
            +  ++D +++A+    W+R + +  LE  + +  M   Q QK ++F+      +H+  ++
Sbjct: 2650 QAFLQDSQEVAA----WLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQEL 2705

Query: 329  QEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRR 388
            Q + Q          +L     PA    + R+  ++   WG L+           N  ++
Sbjct: 2706 QREGQ----------RLLQGGHPASEAIQERL-EELGALWGELQD----------NSQKK 2744

Query: 389  LERLDHLAEKFRQKASIHEA--WTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAA 446
            + +L    E  R + S+ E   W +  E  LR      A L  +  LL      E+ +  
Sbjct: 2745 VAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQA-LPGVGELLGTQRELEAAVDK 2803

Query: 447  HQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLET 506
               + E +   AQ      +  +  V  + +++  ++ +L    Q+RR ALE    LL+ 
Sbjct: 2804 KARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKF 2863

Query: 507  IDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERL 566
                  E A        W++  +          ++  ++ L   H+  ++ +   +    
Sbjct: 2864 FRDADEEMA--------WVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTR 2915

Query: 567  AILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQ 626
             +LG      K+VQ  H              Q++     H+R    RR   L +    Q 
Sbjct: 2916 VVLGTG---YKLVQAGHF----AAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQ- 2967

Query: 627  HNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYE---KSIVNYKP 683
                   QF  +    G W+  +   +   S +M  + E   + LR+ E   + +  + P
Sbjct: 2968 -------QFLTELLEAGSWLAERGHVLD--SEDMGHSAEATQALLRRLEATKRDLEAFSP 3018

Query: 684  KIDQLEGDHQLIQ 696
            +I++L+    L++
Sbjct: 3019 RIERLQQTAALLE 3031



 Score = 33.9 bits (76), Expect = 0.69
 Identities = 42/183 (22%), Positives = 69/183 (37%), Gaps = 23/183 (12%)

Query: 356  SEGRMV----SDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTD 411
            S G MV     D+  AW          E W L + R    L       R    + E  T 
Sbjct: 1768 SAGPMVRQRQQDLQTAWS---------ELWELTQARG-HALRDTETTLRVHRDLLEVLTQ 1817

Query: 412  GKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNEL-DYYDSP 470
             +E      +     L  ++A L+ H+  E +L   + +++++   A  + +L     + 
Sbjct: 1818 VQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAH 1877

Query: 471  SVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAME 530
            +V  R Q +   W  L    ++RR  LER  +LL        +YA       +W     +
Sbjct: 1878 AVQQRQQAVTQAWAVLQRRMEQRRAQLERA-RLLARFRTAVRDYA-------SWAARVRQ 1929

Query: 531  DLQ 533
            DLQ
Sbjct: 1930 DLQ 1932



 Score = 32.3 bits (72), Expect = 2.0
 Identities = 38/181 (20%), Positives = 73/181 (40%), Gaps = 10/181 (5%)

Query: 388  RLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAH 447
            +LER   LA +FR     + +W       L Q +  +   S     L  H+   ++L A 
Sbjct: 1903 QLERARLLA-RFRTAVRDYASWAARVRQDL-QVEESSQEPSSGPLKLSAHQWLRAELEAR 1960

Query: 448  QDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETI 507
            +   +Q   + Q+        +  V    + + DQ D +     +++E L+  ++     
Sbjct: 1961 EKLWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQ----- 2015

Query: 508  DQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLA 567
            +QL+L    R       +      L+ + +  ++EE++ L   HE F   L   DK+  A
Sbjct: 2016 EQLFLRECGRLEEI---LAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAA 2072

Query: 568  I 568
            +
Sbjct: 2073 L 2073



 Score = 30.0 bits (66), Expect = 10.0
 Identities = 24/107 (22%), Positives = 41/107 (38%), Gaps = 8/107 (7%)

Query: 427 LSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNL 486
           LS+I   L+KH+A E+++  HQ     +    ++L+       P    R + +   W  L
Sbjct: 636 LSQIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLL 695

Query: 487 GALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQ 533
                 R   L+           L L+Y   AA   +W+      L+
Sbjct: 696 QTRVVGRGARLQTA--------LLVLQYFADAAEAASWLRERRSSLE 734


>gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
            isoform 2 [Homo sapiens]
          Length = 2472

 Score =  288 bits (738), Expect = 1e-77
 Identities = 167/501 (33%), Positives = 282/501 (56%), Gaps = 21/501 (4%)

Query: 398  KFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAA-HQDRVEQIAA 456
            +F  KA + E+W   KE  L+  DY    LS ++ LL K E F++ L A  Q+ +  I A
Sbjct: 1980 QFNWKADVVESWIGEKENSLKTDDYGR-DLSSVQTLLTKQETFDAGLQAFQQEGIANITA 2038

Query: 457  IAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAK 516
            +  +L    +  S ++ AR   +  +W  L A +  R++ L   +     ++ L+L +AK
Sbjct: 2039 LKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAK 2098

Query: 517  RAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDA--DKERLAILGIHNE 574
            +A+ FN+W E A EDL D    +++EEI+ L  AH+ F+++L  A  D  +LA      E
Sbjct: 2099 KASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLA------E 2152

Query: 575  VSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQ 634
            + + ++++ V    +NPYT  T + +   W ++++++  R+  L +E  RQ+ N++LR++
Sbjct: 2153 LDRQIKSFRV---ASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQE 2209

Query: 635  FGAQANVIGPWIQTKMEEI--GRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDH 692
            F   AN    WIQ     +  G   +E  GTLE QL   ++  + I   + ++ ++E   
Sbjct: 2210 FAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLG 2269

Query: 693  QLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFR 752
              ++EALI DNK+T ++   +   W+QL     R  + +E QI  R+  G+++E + EF 
Sbjct: 2270 AAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFS 2329

Query: 753  ASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQGE--AEFARIMSIVDPNRLGVVTFQ 810
              F HFD+D SG L  +EFK+CL SLGYD+    +GE   EF  I+  VDPNR G V+ Q
Sbjct: 2330 MMFKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDGHVSLQ 2389

Query: 811  AFIDFM-SRETADTDTADQVMASFKILAGD-KNYITMDELRRELPPDQAEYCIARMAPYT 868
             ++ FM SRET +  +++++ ++F+ L+ + K Y+T +EL + L  +QA+YC++ M PY 
Sbjct: 2390 EYMAFMISRETENVKSSEEIESAFRALSSEGKPYVTKEELYQNLTREQADYCVSHMKPYV 2449

Query: 869  GPD--SVPGALDYMSFSTALY 887
                  +P A DY+ F+ +L+
Sbjct: 2450 DGKGRELPTAFDYVEFTRSLF 2470



 Score = 83.6 bits (205), Expect = 8e-16
 Identities = 83/382 (21%), Positives = 162/382 (42%), Gaps = 47/382 (12%)

Query: 388  RLERLDHLAE--KFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLA 445
            R +RL+   E  +F       EAW + K  ++  +DY   TL+ I+ LLKKHEAFE+D  
Sbjct: 1862 RGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGD-TLAAIQGLLKKHEAFETDFT 1920

Query: 446  AHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLE 505
             H+DRV  +    Q+L + + +   +++++ + +       G ++   + A +R  KL E
Sbjct: 1921 VHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGL------NGKVSDLEKAAAQRKAKLDE 1974

Query: 506  TIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKER 565
              +  +L++  +A    +W+      L+       +  +Q L T  E F A L    +E 
Sbjct: 1975 --NSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEG 2032

Query: 566  LA--------ILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQA 617
            +A        +L   +  SK ++  H ++                +W  +      R + 
Sbjct: 2033 IANITALKDQLLAAKHVQSKAIEARHASLM--------------KRWSQLLANSAARKKK 2078

Query: 618  LTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQ---- 673
            L E  +  +  E L   F  +A+    W +   E+   ++  +     +++  LR+    
Sbjct: 2079 LLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEED---LTDPVRCNSLEEIKALREAHDA 2135

Query: 674  YEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVEN 733
            +  S+ + +   +QL    + I+   +  N +T +TME +   W  L     + I E E 
Sbjct: 2136 FRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNL----QKIIKEREL 2191

Query: 734  QILTRDAKGISQEQMNEFRASF 755
            ++     +   QE+ ++ R  F
Sbjct: 2192 ELQKEQRR---QEENDKLRQEF 2210



 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 82/385 (21%), Positives = 153/385 (39%), Gaps = 41/385 (10%)

Query: 274  QLMEDYEKLA-SDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKC 332
            Q++E   KL  S  L+   R +  +E  + E    A  +  +D  + +  H+  +  E  
Sbjct: 1539 QMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQSKHQKHQAFE-A 1597

Query: 333  QLEINFNTLQTKLRLSN----RPAFMPSEGRM---VSDINNAWGCLEQVEKGYEEWLLNE 385
            +L  N + ++  + + N    R A   SE  +   ++ + + W  L Q +   +   L E
Sbjct: 1598 ELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQ-KSAEKSQKLKE 1656

Query: 386  IRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLA 445
              + +  +   + F       + W    EA+L  +DY    L+ +  LLKKH+  E+D++
Sbjct: 1657 ANKQQNFNTGIKDF-------DFWLSEVEALLASEDYGK-DLASVNNLLKKHQLLEADIS 1708

Query: 446  AHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLE 505
            AH+DR++ + + A  L     +D+  V  +   I  ++  + ++   RR  L  + +L +
Sbjct: 1709 AHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQ 1768

Query: 506  TIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKER 565
                +  E         +W++     +        +  +Q L   H++ +A L   +   
Sbjct: 1769 FFRDMDDE--------ESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEP-- 1818

Query: 566  LAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQ 625
             AI G+ +   K+      N  G         Q +   W  ++QL   R Q L E    Q
Sbjct: 1819 -AIQGVLDTGKKLSDD---NTIGKEEIQQRLAQFVE-HWKELKQLAAARGQRLEESLEYQ 1873

Query: 626  QHNERLRKQFGAQANVIGPWIQTKM 650
                    QF A       WI  KM
Sbjct: 1874 --------QFVANVEEEEAWINEKM 1890



 Score = 60.1 bits (144), Expect = 9e-09
 Identities = 54/250 (21%), Positives = 109/250 (43%), Gaps = 19/250 (7%)

Query: 386  IRRLERLDHLAEK--FRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESD 443
            ++R   LD   E   F +     E W   +EA L  +D +  +L  ++AL+KKHE F+  
Sbjct: 1435 VQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTED-KGDSLDSVEALIKKHEDFDKA 1493

Query: 444  LAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKL 503
            +   ++++  + A A +L    +Y    +++R  ++ D+W  L A      + +E+  KL
Sbjct: 1494 INVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKA------QMIEKRSKL 1547

Query: 504  LETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATL-PDAD 562
             E+  Q   ++++       W+   ++   D         IQ     H+ F+A L  +AD
Sbjct: 1548 GES--QTLQQFSRDVDEIEAWISEKLQTASDESYKDP-TNIQSKHQKHQAFEAELHANAD 1604

Query: 563  KERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEH 622
            +    I G+ +  + +++      AG+          +  +W  + Q    + Q L E +
Sbjct: 1605 R----IRGVIDMGNSLIE--RGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEAN 1658

Query: 623  ARQQHNERLR 632
             +Q  N  ++
Sbjct: 1659 KQQNFNTGIK 1668



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 72/348 (20%), Positives = 142/348 (40%), Gaps = 49/348 (14%)

Query: 383 LNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFES 442
           LN+  RL+R   LA+ FR   S    W    +A++   D   + ++  +ALL +H+  + 
Sbjct: 357 LNDSYRLQRF--LAD-FRDLTS----WVTEMKALINA-DELASDVAGAEALLDRHQEHKG 408

Query: 443 DLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEK 502
           ++ AH+D  +      Q L    +Y S  V  +   + ++   L  L + RR+  E+   
Sbjct: 409 EIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMD 468

Query: 503 LLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDAD 562
           L     QL+    ++    +NWM      L +  +  +++ ++ L   HE F+ +L  A 
Sbjct: 469 L-----QLFYRDTEQV---DNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSL-SAQ 519

Query: 563 KERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEH 622
           +E+  I  +    +K++Q  H  M                       +  RRD  L+  +
Sbjct: 520 EEK--ITALDEFATKLIQNNHYAM---------------------EDVATRRDALLSRRN 556

Query: 623 ARQQHNERLR---------KQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQ 673
           A  +   R R         +QF   ++ +  W+  KM+     + +    L+ ++   + 
Sbjct: 557 ALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQA 616

Query: 674 YEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLL 721
           +E  +   + +ID LE   Q + +   +        M  +   W++LL
Sbjct: 617 FEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLL 664



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 36/137 (26%), Positives = 63/137 (45%), Gaps = 9/137 (6%)

Query: 361  VSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQK 420
            + ++N  W  L+Q        L  E  +L    H  ++F + A   + W + K   L   
Sbjct: 1208 IKELNERWRSLQQ--------LAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTD 1259

Query: 421  DYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKIC 480
            +Y    L+ ++AL +KHE FE DLAA  D+V  +   A+ L +     +  +  +C ++ 
Sbjct: 1260 NYGH-DLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELN 1318

Query: 481  DQWDNLGALTQKRREAL 497
              W +LG    +R+  L
Sbjct: 1319 QAWSSLGKRADQRKAKL 1335



 Score = 57.0 bits (136), Expect = 8e-08
 Identities = 68/347 (19%), Positives = 143/347 (41%), Gaps = 31/347 (8%)

Query: 383 LNEIRRLERLDHLAEKFRQK-ASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFE 441
           L+ +RR +  D    +F Q+ A   E W   K  +   ++Y+  T   ++  L+KH+AFE
Sbjct: 32  LSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENYKDPT--NLQGKLQKHQAFE 89

Query: 442 SDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTE 501
           +++ A+   + ++      +    ++ S ++  R  ++  QW+    L +K R   E+  
Sbjct: 90  AEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWE---LLLEKMR---EKGI 143

Query: 502 KLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDA 561
           KLL+   Q  ++Y +      +W+      +    +   +E ++ L    E+F+  +  A
Sbjct: 144 KLLQA--QKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMA-A 200

Query: 562 DKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEE 621
            +ER  +  ++   +K++Q  H               E+N  W  ++ L  +R   L   
Sbjct: 201 HEER--VNEVNQFAAKLIQEQHPE----EELIKTKQDEVNAAWQRLKGLALQRQGKLFGA 254

Query: 622 HARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQY---EKSI 678
              Q+ N  + +           WI+ K + +   S +    L    + LR++   E+ +
Sbjct: 255 AEVQRFNRDVDETIS--------WIKEKEQLMA--SDDFGRDLASVQALLRKHEGLERDL 304

Query: 679 VNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIA 725
              + K+  L  +   +Q++            E +   WEQ+ T  A
Sbjct: 305 AALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAA 351



 Score = 57.0 bits (136), Expect = 8e-08
 Identities = 53/235 (22%), Positives = 102/235 (43%), Gaps = 25/235 (10%)

Query: 274 QLMEDYEKLASDLLEWIR-RTIPWLENRVPENTMHA--MQQKLEDFRDYRRLHKPPKVQE 330
           Q +  Y +   D+++WI  +        + ++  H   +Q+K E+F+     H+  +V E
Sbjct: 149 QKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEE-RVNE 207

Query: 331 KCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLE 390
                   N    KL     P     + +   ++N AW  L+ +           ++R  
Sbjct: 208 -------VNQFAAKLIQEQHPEEELIKTKQ-DEVNAAWQRLKGLA----------LQRQG 249

Query: 391 RLDHLAEKFRQKASIHE--AWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQ 448
           +L   AE  R    + E  +W   KE ++   D+    L+ ++ALL+KHE  E DLAA +
Sbjct: 250 KLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGR-DLASVQALLRKHEGLERDLAALE 308

Query: 449 DRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKL 503
           D+V+ + A A  L +     +  +  + +++   W+ +  L  +R   L  + +L
Sbjct: 309 DKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRL 363



 Score = 57.0 bits (136), Expect = 8e-08
 Identities = 57/286 (19%), Positives = 118/286 (41%), Gaps = 31/286 (10%)

Query: 397 EKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAA 456
           ++F +     E W    E  L   DY    L+ ++ L KKH   E+D+AAHQDR++ I  
Sbjct: 681 QQFNRNVEDIELWLYEVEGHLASDDYGK-DLTNVQNLQKKHALLEADVAAHQDRIDGITI 739

Query: 457 IAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLET--IDQLYLEY 514
            A++  +  ++D+ ++  + + +  +++ L      +   + R +KL ++  + QL+ + 
Sbjct: 740 QARQFQDAGHFDAENIKKKQEALVARYEAL------KEPMVARKQKLADSLRLQQLFRDV 793

Query: 515 AKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNE 574
                    W+         T     +  +Q L   H+  +A +   +     I  +  +
Sbjct: 794 EDE----ETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPR---IKAVTQK 846

Query: 575 VSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQ 634
            + +V+  H               E+N KW+ ++    +R Q L +    Q        Q
Sbjct: 847 GNAMVEEGHFAAEDVKAKL----HELNQKWEALKAKASQRRQDLEDSLQAQ--------Q 894

Query: 635 FGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVN 680
           + A AN    W++ K   +G      +G  ED    L +  +++++
Sbjct: 895 YFADANEAESWMREKEPIVGSTD---YGKDEDSAEALLKKHEALMS 937



 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 65/317 (20%), Positives = 127/317 (40%), Gaps = 34/317 (10%)

Query: 409 WTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYD 468
           W   +EA L  +D   + L  ++ALLKKHE FE  L+A ++++  +   A +L + ++Y 
Sbjct: 482 WMSKQEAFLLNEDLGDS-LDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYA 540

Query: 469 SPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYL-EYAKRAAPFNNWMEG 527
              V  R   +  + + L     +RR  L          D  +L ++ + +    +W+  
Sbjct: 541 MEDVATRRDALLSRRNALHERAMRRRAQL---------ADSFHLQQFFRDSDELKSWVNE 591

Query: 528 AMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMA 587
            M+   D         +QG    H+ F+A L  A++ R+  L       K++   H    
Sbjct: 592 KMKTATDE-AYKDPSNLQGKVQKHQAFEAEL-SANQSRIDAL--EKAGQKLIDVNHY--- 644

Query: 588 GTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQ 647
                      E+   W  + +    +   L E + +QQ N  +          I  W+ 
Sbjct: 645 -AKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVED--------IELWL- 694

Query: 648 TKMEEIGRISIEMHGTLEDQLSHLRQ----YEKSIVNYKPKIDQLEGDHQLIQEALIFDN 703
              E  G ++ + +G     + +L++     E  +  ++ +ID +    +  Q+A  FD 
Sbjct: 695 --YEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDA 752

Query: 704 KHTNYTMEHIRVGWEQL 720
           ++     E +   +E L
Sbjct: 753 ENIKKKQEALVARYEAL 769



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 33/121 (27%), Positives = 64/121 (52%), Gaps = 9/121 (7%)

Query: 387 RRLERLD--HLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDL 444
           RR +  D  HL + FR    + ++W + K      + Y+    S ++  ++KH+AFE++L
Sbjct: 565 RRAQLADSFHLQQFFRDSDEL-KSWVNEKMKTATDEAYKDP--SNLQGKVQKHQAFEAEL 621

Query: 445 AAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQ----KRREALERT 500
           +A+Q R++ +    Q+L ++++Y    V AR  ++   W  L   T+    K REA ++ 
Sbjct: 622 SANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQ 681

Query: 501 E 501
           +
Sbjct: 682 Q 682



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 65/326 (19%), Positives = 136/326 (41%), Gaps = 54/326 (16%)

Query: 339  NTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEK 398
            N L+ +  ++ R   + ++ R+  +  +    ++QVE+ Y   L    +R   L+   +K
Sbjct: 1034 NLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKK 1093

Query: 399  FR--QKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAA 456
            F   ++A+  + W + KEA L  ++   A L +++ L KK + F+ DL A++ R++ I  
Sbjct: 1094 FMLFREANELQQWINEKEAALTSEEVG-ADLEQVEVLQKKFDDFQKDLKANESRLKDINK 1152

Query: 457  IAQELN-------------ELDYYD------------SPSVNARC-----------QKIC 480
            +A++L              + + Y             SP  +AR            +++ 
Sbjct: 1153 VAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELN 1212

Query: 481  DQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHT 540
            ++W +L  L ++R + L    ++          + + A     W+E   + L      H 
Sbjct: 1213 ERWRSLQQLAEERSQLLGSAHEVQR--------FHRDADETKEWIEEKNQALNTDNYGHD 1264

Query: 541  IEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEI 600
            +  +Q L   HE F+  L  A  +++  LG      +++Q++  +        T    E+
Sbjct: 1265 LASVQALQRKHEGFERDLA-ALGDKVNSLG--ETAERLIQSHPESAEDLQEKCT----EL 1317

Query: 601  NGKWDHVRQLVPRRDQALTEEHARQQ 626
            N  W  + +   +R   L + H  Q+
Sbjct: 1318 NQAWSSLGKRADQRKAKLGDSHDLQR 1343



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 27/114 (23%), Positives = 59/114 (51%), Gaps = 8/114 (7%)

Query: 391 RLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSE------IKALLKKHEAFESDL 444
           R   LA+  R +    +   + +E  +R+K+   A+ +       ++ LLKKH+A ++++
Sbjct: 776 RKQKLADSLRLQQLFRDV--EDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEI 833

Query: 445 AAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALE 498
           A H+ R++ +      + E  ++ +  V A+  ++  +W+ L A   +RR+ LE
Sbjct: 834 AGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLE 887



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 55/290 (18%), Positives = 115/290 (39%), Gaps = 32/290 (11%)

Query: 362  SDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKD 421
            +++N AW  L +      +  L +   L+R       FR   S    W +G   ++   D
Sbjct: 1315 TELNQAWSSLGK-RADQRKAKLGDSHDLQRF---LSDFRDLMS----WINGIRGLV-SSD 1365

Query: 422  YETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICD 481
                 ++  +ALL++H+   +++ A     +      Q+L    +Y SP +  +   +  
Sbjct: 1366 ELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQ 1425

Query: 482  QWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTI 541
            +  +L     +RR  L++  +L     QL+    ++A    NWM      L       ++
Sbjct: 1426 ERADLEKAWVQRRMMLDQCLEL-----QLFHRDCEQA---ENWMAAREAFLNTEDKGDSL 1477

Query: 542  EEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEIN 601
            + ++ L   HE F   + +  +E++A L          Q +   +     Y      +I+
Sbjct: 1478 DSVEALIKKHEDFDKAI-NVQEEKIAAL----------QAFADQLIAAGHY---AKGDIS 1523

Query: 602  GKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKME 651
             + + V     R    + E+ ++   ++ L +QF    + I  WI  K++
Sbjct: 1524 SRRNEVLDRWRRLKAQMIEKRSKLGESQTL-QQFSRDVDEIEAWISEKLQ 1572



 Score = 38.5 bits (88), Expect = 0.028
 Identities = 27/78 (34%), Positives = 42/78 (53%), Gaps = 2/78 (2%)

Query: 387 RRLERLDHL-AEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLA 445
           RR +  D L A+++   A+  E+W   KE ++   DY     S  +ALLKKHEA  SDL+
Sbjct: 882 RRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSA-EALLKKHEALMSDLS 940

Query: 446 AHQDRVEQIAAIAQELNE 463
           A+   ++ +   AQ   +
Sbjct: 941 AYGSSIQALREQAQSCRQ 958



 Score = 31.6 bits (70), Expect = 3.4
 Identities = 52/256 (20%), Positives = 103/256 (40%), Gaps = 52/256 (20%)

Query: 432  ALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYY-----DSPSVNARCQKICDQWDNL 486
            A +KK +  +S  A+ ++ +E+  +IA    ++D       ++ SV+ R +++ + + +L
Sbjct: 1019 AYVKKLDPAQS--ASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSL 1076

Query: 487  GALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQG 546
              L +KR+  LE++ K             + A     W+      L    +   +E+++ 
Sbjct: 1077 LELGEKRKGMLEKSCKKFMLF--------REANELQQWINEKEAALTSEEVGADLEQVEV 1128

Query: 547  LTTAHEQFK-------ATLPDADK--ERLAILGIHNEVSKIVQTYHV---------NMAG 588
            L    + F+       + L D +K  E L   G+  E  + VQ   V         +   
Sbjct: 1129 LQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKT 1188

Query: 589  TNPY-----------TTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGA 637
             +P+           T  + +E+N +W  ++QL   R Q L   H  Q        +F  
Sbjct: 1189 ASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQ--------RFHR 1240

Query: 638  QANVIGPWIQTKMEEI 653
             A+    WI+ K + +
Sbjct: 1241 DADETKEWIEEKNQAL 1256


>gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
            isoform 1 [Homo sapiens]
          Length = 2477

 Score =  288 bits (738), Expect = 1e-77
 Identities = 167/501 (33%), Positives = 282/501 (56%), Gaps = 21/501 (4%)

Query: 398  KFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAA-HQDRVEQIAA 456
            +F  KA + E+W   KE  L+  DY    LS ++ LL K E F++ L A  Q+ +  I A
Sbjct: 1985 QFNWKADVVESWIGEKENSLKTDDYGR-DLSSVQTLLTKQETFDAGLQAFQQEGIANITA 2043

Query: 457  IAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAK 516
            +  +L    +  S ++ AR   +  +W  L A +  R++ L   +     ++ L+L +AK
Sbjct: 2044 LKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAK 2103

Query: 517  RAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDA--DKERLAILGIHNE 574
            +A+ FN+W E A EDL D    +++EEI+ L  AH+ F+++L  A  D  +LA      E
Sbjct: 2104 KASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLA------E 2157

Query: 575  VSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQ 634
            + + ++++ V    +NPYT  T + +   W ++++++  R+  L +E  RQ+ N++LR++
Sbjct: 2158 LDRQIKSFRV---ASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQE 2214

Query: 635  FGAQANVIGPWIQTKMEEI--GRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDH 692
            F   AN    WIQ     +  G   +E  GTLE QL   ++  + I   + ++ ++E   
Sbjct: 2215 FAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLG 2274

Query: 693  QLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFR 752
              ++EALI DNK+T ++   +   W+QL     R  + +E QI  R+  G+++E + EF 
Sbjct: 2275 AAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFS 2334

Query: 753  ASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQGE--AEFARIMSIVDPNRLGVVTFQ 810
              F HFD+D SG L  +EFK+CL SLGYD+    +GE   EF  I+  VDPNR G V+ Q
Sbjct: 2335 MMFKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDGHVSLQ 2394

Query: 811  AFIDFM-SRETADTDTADQVMASFKILAGD-KNYITMDELRRELPPDQAEYCIARMAPYT 868
             ++ FM SRET +  +++++ ++F+ L+ + K Y+T +EL + L  +QA+YC++ M PY 
Sbjct: 2395 EYMAFMISRETENVKSSEEIESAFRALSSEGKPYVTKEELYQNLTREQADYCVSHMKPYV 2454

Query: 869  GPD--SVPGALDYMSFSTALY 887
                  +P A DY+ F+ +L+
Sbjct: 2455 DGKGRELPTAFDYVEFTRSLF 2475



 Score = 83.6 bits (205), Expect = 8e-16
 Identities = 83/382 (21%), Positives = 162/382 (42%), Gaps = 47/382 (12%)

Query: 388  RLERLDHLAE--KFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLA 445
            R +RL+   E  +F       EAW + K  ++  +DY   TL+ I+ LLKKHEAFE+D  
Sbjct: 1867 RGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGD-TLAAIQGLLKKHEAFETDFT 1925

Query: 446  AHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLE 505
             H+DRV  +    Q+L + + +   +++++ + +       G ++   + A +R  KL E
Sbjct: 1926 VHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGL------NGKVSDLEKAAAQRKAKLDE 1979

Query: 506  TIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKER 565
              +  +L++  +A    +W+      L+       +  +Q L T  E F A L    +E 
Sbjct: 1980 --NSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEG 2037

Query: 566  LA--------ILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQA 617
            +A        +L   +  SK ++  H ++                +W  +      R + 
Sbjct: 2038 IANITALKDQLLAAKHVQSKAIEARHASLM--------------KRWSQLLANSAARKKK 2083

Query: 618  LTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQ---- 673
            L E  +  +  E L   F  +A+    W +   E+   ++  +     +++  LR+    
Sbjct: 2084 LLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEED---LTDPVRCNSLEEIKALREAHDA 2140

Query: 674  YEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVEN 733
            +  S+ + +   +QL    + I+   +  N +T +TME +   W  L     + I E E 
Sbjct: 2141 FRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNL----QKIIKEREL 2196

Query: 734  QILTRDAKGISQEQMNEFRASF 755
            ++     +   QE+ ++ R  F
Sbjct: 2197 ELQKEQRR---QEENDKLRQEF 2215



 Score = 60.1 bits (144), Expect = 9e-09
 Identities = 50/250 (20%), Positives = 110/250 (44%), Gaps = 14/250 (5%)

Query: 386  IRRLERLDHLAEK--FRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESD 443
            ++R   LD   E   F +     E W   +EA L  +D +  +L  ++AL+KKHE F+  
Sbjct: 1435 VQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTED-KGDSLDSVEALIKKHEDFDKA 1493

Query: 444  LAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKL 503
            +   ++++  + A A +L    +Y    +++R  ++ D+W  L A      + +E+  KL
Sbjct: 1494 INVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKA------QMIEKRSKL 1547

Query: 504  LETIDQLYLEYAKRAAPFNNWMEGAMEDLQD-TFIVHTIEEIQGLTTAHEQFKATLPDAD 562
             E+  Q   ++++       W+   ++   D ++   T  ++  L + H++ +A   +  
Sbjct: 1548 GES--QTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELH 1605

Query: 563  KERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEH 622
                 I G+ +  + +++      AG+          +  +W  + Q    + Q L E +
Sbjct: 1606 ANADRIRGVIDMGNSLIE--RGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEAN 1663

Query: 623  ARQQHNERLR 632
             +Q  N  ++
Sbjct: 1664 KQQNFNTGIK 1673



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 72/348 (20%), Positives = 142/348 (40%), Gaps = 49/348 (14%)

Query: 383 LNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFES 442
           LN+  RL+R   LA+ FR   S    W    +A++   D   + ++  +ALL +H+  + 
Sbjct: 357 LNDSYRLQRF--LAD-FRDLTS----WVTEMKALINA-DELASDVAGAEALLDRHQEHKG 408

Query: 443 DLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEK 502
           ++ AH+D  +      Q L    +Y S  V  +   + ++   L  L + RR+  E+   
Sbjct: 409 EIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMD 468

Query: 503 LLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDAD 562
           L     QL+    ++    +NWM      L +  +  +++ ++ L   HE F+ +L  A 
Sbjct: 469 L-----QLFYRDTEQV---DNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSL-SAQ 519

Query: 563 KERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEH 622
           +E+  I  +    +K++Q  H  M                       +  RRD  L+  +
Sbjct: 520 EEK--ITALDEFATKLIQNNHYAM---------------------EDVATRRDALLSRRN 556

Query: 623 ARQQHNERLR---------KQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQ 673
           A  +   R R         +QF   ++ +  W+  KM+     + +    L+ ++   + 
Sbjct: 557 ALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQA 616

Query: 674 YEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLL 721
           +E  +   + +ID LE   Q + +   +        M  +   W++LL
Sbjct: 617 FEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLL 664



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 36/137 (26%), Positives = 63/137 (45%), Gaps = 9/137 (6%)

Query: 361  VSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQK 420
            + ++N  W  L+Q        L  E  +L    H  ++F + A   + W + K   L   
Sbjct: 1208 IKELNERWRSLQQ--------LAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTD 1259

Query: 421  DYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKIC 480
            +Y    L+ ++AL +KHE FE DLAA  D+V  +   A+ L +     +  +  +C ++ 
Sbjct: 1260 NYGH-DLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELN 1318

Query: 481  DQWDNLGALTQKRREAL 497
              W +LG    +R+  L
Sbjct: 1319 QAWSSLGKRADQRKAKL 1335



 Score = 57.4 bits (137), Expect = 6e-08
 Identities = 84/389 (21%), Positives = 154/389 (39%), Gaps = 44/389 (11%)

Query: 274  QLMEDYEKLA-SDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDY---RRLHKPPKVQ 329
            Q++E   KL  S  L+   R +  +E  + E    A  +  +D  +    + L K  K Q
Sbjct: 1539 QMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQ 1598

Query: 330  E-KCQLEINFNTLQTKLRLSN----RPAFMPSEGRM---VSDINNAWGCLEQVEKGYEEW 381
              + +L  N + ++  + + N    R A   SE  +   ++ + + W  L Q +   +  
Sbjct: 1599 AFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQ-KSAEKSQ 1657

Query: 382  LLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFE 441
             L E  + +  +   + F       + W    EA+L  +DY    L+ +  LLKKH+  E
Sbjct: 1658 KLKEANKQQNFNTGIKDF-------DFWLSEVEALLASEDYGK-DLASVNNLLKKHQLLE 1709

Query: 442  SDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTE 501
            +D++AH+DR++ + + A  L     +D+  V  +   I  ++  + ++   RR  L  + 
Sbjct: 1710 ADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESH 1769

Query: 502  KLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDA 561
            +L +    +  E         +W++     +        +  +Q L   H++ +A L   
Sbjct: 1770 RLHQFFRDMDDE--------ESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAH 1821

Query: 562  DKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEE 621
            +    AI G+ +   K+      N  G         Q +   W  ++QL   R Q L E 
Sbjct: 1822 EP---AIQGVLDTGKKLSDD---NTIGKEEIQQRLAQFVE-HWKELKQLAAARGQRLEES 1874

Query: 622  HARQQHNERLRKQFGAQANVIGPWIQTKM 650
               Q        QF A       WI  KM
Sbjct: 1875 LEYQ--------QFVANVEEEEAWINEKM 1895



 Score = 57.0 bits (136), Expect = 8e-08
 Identities = 68/347 (19%), Positives = 143/347 (41%), Gaps = 31/347 (8%)

Query: 383 LNEIRRLERLDHLAEKFRQK-ASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFE 441
           L+ +RR +  D    +F Q+ A   E W   K  +   ++Y+  T   ++  L+KH+AFE
Sbjct: 32  LSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENYKDPT--NLQGKLQKHQAFE 89

Query: 442 SDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTE 501
           +++ A+   + ++      +    ++ S ++  R  ++  QW+    L +K R   E+  
Sbjct: 90  AEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWE---LLLEKMR---EKGI 143

Query: 502 KLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDA 561
           KLL+   Q  ++Y +      +W+      +    +   +E ++ L    E+F+  +  A
Sbjct: 144 KLLQA--QKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMA-A 200

Query: 562 DKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEE 621
            +ER  +  ++   +K++Q  H               E+N  W  ++ L  +R   L   
Sbjct: 201 HEER--VNEVNQFAAKLIQEQHPE----EELIKTKQDEVNAAWQRLKGLALQRQGKLFGA 254

Query: 622 HARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQY---EKSI 678
              Q+ N  + +           WI+ K + +   S +    L    + LR++   E+ +
Sbjct: 255 AEVQRFNRDVDETIS--------WIKEKEQLMA--SDDFGRDLASVQALLRKHEGLERDL 304

Query: 679 VNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIA 725
              + K+  L  +   +Q++            E +   WEQ+ T  A
Sbjct: 305 AALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAA 351



 Score = 57.0 bits (136), Expect = 8e-08
 Identities = 53/235 (22%), Positives = 102/235 (43%), Gaps = 25/235 (10%)

Query: 274 QLMEDYEKLASDLLEWIR-RTIPWLENRVPENTMHA--MQQKLEDFRDYRRLHKPPKVQE 330
           Q +  Y +   D+++WI  +        + ++  H   +Q+K E+F+     H+  +V E
Sbjct: 149 QKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEE-RVNE 207

Query: 331 KCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLE 390
                   N    KL     P     + +   ++N AW  L+ +           ++R  
Sbjct: 208 -------VNQFAAKLIQEQHPEEELIKTKQ-DEVNAAWQRLKGLA----------LQRQG 249

Query: 391 RLDHLAEKFRQKASIHE--AWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQ 448
           +L   AE  R    + E  +W   KE ++   D+    L+ ++ALL+KHE  E DLAA +
Sbjct: 250 KLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGR-DLASVQALLRKHEGLERDLAALE 308

Query: 449 DRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKL 503
           D+V+ + A A  L +     +  +  + +++   W+ +  L  +R   L  + +L
Sbjct: 309 DKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRL 363



 Score = 57.0 bits (136), Expect = 8e-08
 Identities = 57/286 (19%), Positives = 118/286 (41%), Gaps = 31/286 (10%)

Query: 397 EKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAA 456
           ++F +     E W    E  L   DY    L+ ++ L KKH   E+D+AAHQDR++ I  
Sbjct: 681 QQFNRNVEDIELWLYEVEGHLASDDYGK-DLTNVQNLQKKHALLEADVAAHQDRIDGITI 739

Query: 457 IAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLET--IDQLYLEY 514
            A++  +  ++D+ ++  + + +  +++ L      +   + R +KL ++  + QL+ + 
Sbjct: 740 QARQFQDAGHFDAENIKKKQEALVARYEAL------KEPMVARKQKLADSLRLQQLFRDV 793

Query: 515 AKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNE 574
                    W+         T     +  +Q L   H+  +A +   +     I  +  +
Sbjct: 794 EDE----ETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPR---IKAVTQK 846

Query: 575 VSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQ 634
            + +V+  H               E+N KW+ ++    +R Q L +    Q        Q
Sbjct: 847 GNAMVEEGHFAAEDVKAKL----HELNQKWEALKAKASQRRQDLEDSLQAQ--------Q 894

Query: 635 FGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVN 680
           + A AN    W++ K   +G      +G  ED    L +  +++++
Sbjct: 895 YFADANEAESWMREKEPIVGSTD---YGKDEDSAEALLKKHEALMS 937



 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 65/317 (20%), Positives = 127/317 (40%), Gaps = 34/317 (10%)

Query: 409 WTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYD 468
           W   +EA L  +D   + L  ++ALLKKHE FE  L+A ++++  +   A +L + ++Y 
Sbjct: 482 WMSKQEAFLLNEDLGDS-LDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYA 540

Query: 469 SPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYL-EYAKRAAPFNNWMEG 527
              V  R   +  + + L     +RR  L          D  +L ++ + +    +W+  
Sbjct: 541 MEDVATRRDALLSRRNALHERAMRRRAQL---------ADSFHLQQFFRDSDELKSWVNE 591

Query: 528 AMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMA 587
            M+   D         +QG    H+ F+A L  A++ R+  L       K++   H    
Sbjct: 592 KMKTATDE-AYKDPSNLQGKVQKHQAFEAEL-SANQSRIDAL--EKAGQKLIDVNHY--- 644

Query: 588 GTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQ 647
                      E+   W  + +    +   L E + +QQ N  +          I  W+ 
Sbjct: 645 -AKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVED--------IELWL- 694

Query: 648 TKMEEIGRISIEMHGTLEDQLSHLRQ----YEKSIVNYKPKIDQLEGDHQLIQEALIFDN 703
              E  G ++ + +G     + +L++     E  +  ++ +ID +    +  Q+A  FD 
Sbjct: 695 --YEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDA 752

Query: 704 KHTNYTMEHIRVGWEQL 720
           ++     E +   +E L
Sbjct: 753 ENIKKKQEALVARYEAL 769



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 33/121 (27%), Positives = 64/121 (52%), Gaps = 9/121 (7%)

Query: 387 RRLERLD--HLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDL 444
           RR +  D  HL + FR    + ++W + K      + Y+    S ++  ++KH+AFE++L
Sbjct: 565 RRAQLADSFHLQQFFRDSDEL-KSWVNEKMKTATDEAYKDP--SNLQGKVQKHQAFEAEL 621

Query: 445 AAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQ----KRREALERT 500
           +A+Q R++ +    Q+L ++++Y    V AR  ++   W  L   T+    K REA ++ 
Sbjct: 622 SANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQ 681

Query: 501 E 501
           +
Sbjct: 682 Q 682



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 65/326 (19%), Positives = 136/326 (41%), Gaps = 54/326 (16%)

Query: 339  NTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEK 398
            N L+ +  ++ R   + ++ R+  +  +    ++QVE+ Y   L    +R   L+   +K
Sbjct: 1034 NLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKK 1093

Query: 399  FR--QKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAA 456
            F   ++A+  + W + KEA L  ++   A L +++ L KK + F+ DL A++ R++ I  
Sbjct: 1094 FMLFREANELQQWINEKEAALTSEEVG-ADLEQVEVLQKKFDDFQKDLKANESRLKDINK 1152

Query: 457  IAQELN-------------ELDYYD------------SPSVNARC-----------QKIC 480
            +A++L              + + Y             SP  +AR            +++ 
Sbjct: 1153 VAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELN 1212

Query: 481  DQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHT 540
            ++W +L  L ++R + L    ++          + + A     W+E   + L      H 
Sbjct: 1213 ERWRSLQQLAEERSQLLGSAHEVQR--------FHRDADETKEWIEEKNQALNTDNYGHD 1264

Query: 541  IEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEI 600
            +  +Q L   HE F+  L  A  +++  LG      +++Q++  +        T    E+
Sbjct: 1265 LASVQALQRKHEGFERDLA-ALGDKVNSLG--ETAERLIQSHPESAEDLQEKCT----EL 1317

Query: 601  NGKWDHVRQLVPRRDQALTEEHARQQ 626
            N  W  + +   +R   L + H  Q+
Sbjct: 1318 NQAWSSLGKRADQRKAKLGDSHDLQR 1343



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 27/114 (23%), Positives = 59/114 (51%), Gaps = 8/114 (7%)

Query: 391 RLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSE------IKALLKKHEAFESDL 444
           R   LA+  R +    +   + +E  +R+K+   A+ +       ++ LLKKH+A ++++
Sbjct: 776 RKQKLADSLRLQQLFRDV--EDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEI 833

Query: 445 AAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALE 498
           A H+ R++ +      + E  ++ +  V A+  ++  +W+ L A   +RR+ LE
Sbjct: 834 AGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLE 887



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 55/290 (18%), Positives = 115/290 (39%), Gaps = 32/290 (11%)

Query: 362  SDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKD 421
            +++N AW  L +      +  L +   L+R       FR   S    W +G   ++   D
Sbjct: 1315 TELNQAWSSLGK-RADQRKAKLGDSHDLQRF---LSDFRDLMS----WINGIRGLV-SSD 1365

Query: 422  YETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICD 481
                 ++  +ALL++H+   +++ A     +      Q+L    +Y SP +  +   +  
Sbjct: 1366 ELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQ 1425

Query: 482  QWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTI 541
            +  +L     +RR  L++  +L     QL+    ++A    NWM      L       ++
Sbjct: 1426 ERADLEKAWVQRRMMLDQCLEL-----QLFHRDCEQA---ENWMAAREAFLNTEDKGDSL 1477

Query: 542  EEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEIN 601
            + ++ L   HE F   + +  +E++A L          Q +   +     Y      +I+
Sbjct: 1478 DSVEALIKKHEDFDKAI-NVQEEKIAAL----------QAFADQLIAAGHY---AKGDIS 1523

Query: 602  GKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKME 651
             + + V     R    + E+ ++   ++ L +QF    + I  WI  K++
Sbjct: 1524 SRRNEVLDRWRRLKAQMIEKRSKLGESQTL-QQFSRDVDEIEAWISEKLQ 1572



 Score = 38.5 bits (88), Expect = 0.028
 Identities = 27/78 (34%), Positives = 42/78 (53%), Gaps = 2/78 (2%)

Query: 387 RRLERLDHL-AEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLA 445
           RR +  D L A+++   A+  E+W   KE ++   DY     S  +ALLKKHEA  SDL+
Sbjct: 882 RRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSA-EALLKKHEALMSDLS 940

Query: 446 AHQDRVEQIAAIAQELNE 463
           A+   ++ +   AQ   +
Sbjct: 941 AYGSSIQALREQAQSCRQ 958



 Score = 31.6 bits (70), Expect = 3.4
 Identities = 52/256 (20%), Positives = 103/256 (40%), Gaps = 52/256 (20%)

Query: 432  ALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYY-----DSPSVNARCQKICDQWDNL 486
            A +KK +  +S  A+ ++ +E+  +IA    ++D       ++ SV+ R +++ + + +L
Sbjct: 1019 AYVKKLDPAQS--ASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSL 1076

Query: 487  GALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQG 546
              L +KR+  LE++ K             + A     W+      L    +   +E+++ 
Sbjct: 1077 LELGEKRKGMLEKSCKKFMLF--------REANELQQWINEKEAALTSEEVGADLEQVEV 1128

Query: 547  LTTAHEQFK-------ATLPDADK--ERLAILGIHNEVSKIVQTYHV---------NMAG 588
            L    + F+       + L D +K  E L   G+  E  + VQ   V         +   
Sbjct: 1129 LQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKT 1188

Query: 589  TNPY-----------TTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGA 637
             +P+           T  + +E+N +W  ++QL   R Q L   H  Q        +F  
Sbjct: 1189 ASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQ--------RFHR 1240

Query: 638  QANVIGPWIQTKMEEI 653
             A+    WI+ K + +
Sbjct: 1241 DADETKEWIEEKNQAL 1256


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score =  242 bits (617), Expect = 1e-63
 Identities = 147/396 (37%), Positives = 218/396 (55%), Gaps = 23/396 (5%)

Query: 30  EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHK 89
           ++ Q+KTFT W N HL KA   I ++ ED RDG  L+ LLEV+SG+ L + E+G+MR HK
Sbjct: 41  DRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFHK 99

Query: 90  ISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISV----EETS 145
           + NV  ALD++  + VKLV+I  ++I DGN K+TLG+IWTIIL F I DI V    E+ +
Sbjct: 100 LQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMT 159

Query: 146 AKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNL 205
           AKE LLLW QR    Y+ +   NF  SW+DG  F A+IHRH+P LID  K+ +   L NL
Sbjct: 160 AKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENL 219

Query: 206 NTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKV 265
           + AF VAE+ L + ++LD ED V   +PDEK+I+TYVSS Y A       +         
Sbjct: 220 DQAFSVAERDLGVTRLLDPED-VDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRA---- 274

Query: 266 LAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKP 325
                E +   ++Y +L   LL+W+R      E R   ++   ++     F  ++ +  P
Sbjct: 275 ----NELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELP 330

Query: 326 PKVQEKCQLEINFNTLQTKL---RLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWL 382
            K  +K + +  + +L+  +   +L   P + P       D+   WG L       E+ L
Sbjct: 331 AKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHP------LDVEKEWGKLHVAILEREKQL 384

Query: 383 LNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLR 418
            +E  RLE L  +  K + +A + E   +  +A+L+
Sbjct: 385 RSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQ 420



 Score = 34.3 bits (77), Expect = 0.53
 Identities = 60/293 (20%), Positives = 117/293 (39%), Gaps = 27/293 (9%)

Query: 254  KAETAANRICKVLAVNQENEQLMEDYEKLASDLLE---WIRRTIPWLENRVPENTMHAMQ 310
            KAE    +  K LA  Q   +L ED E++A  L E     +RT+     R  E +  A +
Sbjct: 2326 KAEAELLQQQKELAQEQAR-RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2384

Query: 311  QKL---EDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNA 367
             KL   E  R   R  +  +   K   EI     +T+L    +   + +           
Sbjct: 2385 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE--------- 2435

Query: 368  WGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASI-----HEAWTDGKEAMLRQKD- 421
               +++ +  ++   L E   +  L+   EK +Q+A +      E  T  +E +L++   
Sbjct: 2436 ---IQRQQSDHDAERLREA--IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2490

Query: 422  YETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICD 481
             + + LSE  +LL++    E + A  +   +   A AQ+L E        +    Q++  
Sbjct: 2491 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2550

Query: 482  QWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQD 534
              +       +  E + R ++ L+ ++Q   +  +  A  N  +   ++ L++
Sbjct: 2551 SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE 2603



 Score = 30.4 bits (67), Expect = 7.7
 Identities = 56/302 (18%), Positives = 118/302 (39%), Gaps = 47/302 (15%)

Query: 210  DVAEKYLDIPKMLDAE---------DIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAAN 260
            D+ E+   + K  D+E         D +   R  E+ I+   +SF  A +G  + E    
Sbjct: 1890 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1949

Query: 261  RICK----VLAVNQENE-------QLMEDYEKLASDLLEWIRRTIPWLEN--RVPENTMH 307
            RI       L   ++ E       QL  + E+   +  E +++++   E   R  +  + 
Sbjct: 1950 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2009

Query: 308  AMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRP---AFMPSEGRMVSDI 364
             +++      + RRL +  + +   QL++     Q +L+   +    A    E  +   +
Sbjct: 2010 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2069

Query: 365  NNAWGCLEQV-----------EKGYEEWLLNE------IRRLERLDHLAEKFRQKASIHE 407
                  L+Q+           E+  E  +  E       R++E  + L +   ++A    
Sbjct: 2070 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2129

Query: 408  AWTDGKEAMLRQKDYETATLSEI-KALLKKHEAFESDLAAHQDRVEQI----AAIAQELN 462
                  E + ++ + E A  ++  +A L++ +A ++++  H+   EQ     A + QEL 
Sbjct: 2130 QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2189

Query: 463  EL 464
             L
Sbjct: 2190 TL 2191


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score =  242 bits (617), Expect = 1e-63
 Identities = 147/396 (37%), Positives = 218/396 (55%), Gaps = 23/396 (5%)

Query: 30  EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHK 89
           ++ Q+KTFT W N HL KA   I ++ ED RDG  L+ LLEV+SG+ L + E+G+MR HK
Sbjct: 45  DRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFHK 103

Query: 90  ISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISV----EETS 145
           + NV  ALD++  + VKLV+I  ++I DGN K+TLG+IWTIIL F I DI V    E+ +
Sbjct: 104 LQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMT 163

Query: 146 AKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNL 205
           AKE LLLW QR    Y+ +   NF  SW+DG  F A+IHRH+P LID  K+ +   L NL
Sbjct: 164 AKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENL 223

Query: 206 NTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKV 265
           + AF VAE+ L + ++LD ED V   +PDEK+I+TYVSS Y A       +         
Sbjct: 224 DQAFSVAERDLGVTRLLDPED-VDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRA---- 278

Query: 266 LAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKP 325
                E +   ++Y +L   LL+W+R      E R   ++   ++     F  ++ +  P
Sbjct: 279 ----NELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELP 334

Query: 326 PKVQEKCQLEINFNTLQTKL---RLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWL 382
            K  +K + +  + +L+  +   +L   P + P       D+   WG L       E+ L
Sbjct: 335 AKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHP------LDVEKEWGKLHVAILEREKQL 388

Query: 383 LNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLR 418
            +E  RLE L  +  K + +A + E   +  +A+L+
Sbjct: 389 RSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQ 424



 Score = 34.3 bits (77), Expect = 0.53
 Identities = 60/293 (20%), Positives = 117/293 (39%), Gaps = 27/293 (9%)

Query: 254  KAETAANRICKVLAVNQENEQLMEDYEKLASDLLE---WIRRTIPWLENRVPENTMHAMQ 310
            KAE    +  K LA  Q   +L ED E++A  L E     +RT+     R  E +  A +
Sbjct: 2330 KAEAELLQQQKELAQEQAR-RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2388

Query: 311  QKL---EDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNA 367
             KL   E  R   R  +  +   K   EI     +T+L    +   + +           
Sbjct: 2389 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE--------- 2439

Query: 368  WGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASI-----HEAWTDGKEAMLRQKD- 421
               +++ +  ++   L E   +  L+   EK +Q+A +      E  T  +E +L++   
Sbjct: 2440 ---IQRQQSDHDAERLREA--IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2494

Query: 422  YETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICD 481
             + + LSE  +LL++    E + A  +   +   A AQ+L E        +    Q++  
Sbjct: 2495 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2554

Query: 482  QWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQD 534
              +       +  E + R ++ L+ ++Q   +  +  A  N  +   ++ L++
Sbjct: 2555 SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE 2607



 Score = 30.4 bits (67), Expect = 7.7
 Identities = 56/302 (18%), Positives = 118/302 (39%), Gaps = 47/302 (15%)

Query: 210  DVAEKYLDIPKMLDAE---------DIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAAN 260
            D+ E+   + K  D+E         D +   R  E+ I+   +SF  A +G  + E    
Sbjct: 1894 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1953

Query: 261  RICK----VLAVNQENE-------QLMEDYEKLASDLLEWIRRTIPWLEN--RVPENTMH 307
            RI       L   ++ E       QL  + E+   +  E +++++   E   R  +  + 
Sbjct: 1954 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2013

Query: 308  AMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRP---AFMPSEGRMVSDI 364
             +++      + RRL +  + +   QL++     Q +L+   +    A    E  +   +
Sbjct: 2014 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2073

Query: 365  NNAWGCLEQV-----------EKGYEEWLLNE------IRRLERLDHLAEKFRQKASIHE 407
                  L+Q+           E+  E  +  E       R++E  + L +   ++A    
Sbjct: 2074 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2133

Query: 408  AWTDGKEAMLRQKDYETATLSEI-KALLKKHEAFESDLAAHQDRVEQI----AAIAQELN 462
                  E + ++ + E A  ++  +A L++ +A ++++  H+   EQ     A + QEL 
Sbjct: 2134 QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2193

Query: 463  EL 464
             L
Sbjct: 2194 TL 2195


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score =  242 bits (617), Expect = 1e-63
 Identities = 147/396 (37%), Positives = 218/396 (55%), Gaps = 23/396 (5%)

Query: 30  EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHK 89
           ++ Q+KTFT W N HL KA   I ++ ED RDG  L+ LLEV+SG+ L + E+G+MR HK
Sbjct: 41  DRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFHK 99

Query: 90  ISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISV----EETS 145
           + NV  ALD++  + VKLV+I  ++I DGN K+TLG+IWTIIL F I DI V    E+ +
Sbjct: 100 LQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMT 159

Query: 146 AKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNL 205
           AKE LLLW QR    Y+ +   NF  SW+DG  F A+IHRH+P LID  K+ +   L NL
Sbjct: 160 AKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENL 219

Query: 206 NTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKV 265
           + AF VAE+ L + ++LD ED V   +PDEK+I+TYVSS Y A       +         
Sbjct: 220 DQAFSVAERDLGVTRLLDPED-VDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRA---- 274

Query: 266 LAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKP 325
                E +   ++Y +L   LL+W+R      E R   ++   ++     F  ++ +  P
Sbjct: 275 ----NELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELP 330

Query: 326 PKVQEKCQLEINFNTLQTKL---RLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWL 382
            K  +K + +  + +L+  +   +L   P + P       D+   WG L       E+ L
Sbjct: 331 AKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHP------LDVEKEWGKLHVAILEREKQL 384

Query: 383 LNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLR 418
            +E  RLE L  +  K + +A + E   +  +A+L+
Sbjct: 385 RSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQ 420



 Score = 34.3 bits (77), Expect = 0.53
 Identities = 60/293 (20%), Positives = 117/293 (39%), Gaps = 27/293 (9%)

Query: 254  KAETAANRICKVLAVNQENEQLMEDYEKLASDLLE---WIRRTIPWLENRVPENTMHAMQ 310
            KAE    +  K LA  Q   +L ED E++A  L E     +RT+     R  E +  A +
Sbjct: 2326 KAEAELLQQQKELAQEQAR-RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2384

Query: 311  QKL---EDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNA 367
             KL   E  R   R  +  +   K   EI     +T+L    +   + +           
Sbjct: 2385 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE--------- 2435

Query: 368  WGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASI-----HEAWTDGKEAMLRQKD- 421
               +++ +  ++   L E   +  L+   EK +Q+A +      E  T  +E +L++   
Sbjct: 2436 ---IQRQQSDHDAERLREA--IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2490

Query: 422  YETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICD 481
             + + LSE  +LL++    E + A  +   +   A AQ+L E        +    Q++  
Sbjct: 2491 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2550

Query: 482  QWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQD 534
              +       +  E + R ++ L+ ++Q   +  +  A  N  +   ++ L++
Sbjct: 2551 SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE 2603



 Score = 30.4 bits (67), Expect = 7.7
 Identities = 56/302 (18%), Positives = 118/302 (39%), Gaps = 47/302 (15%)

Query: 210  DVAEKYLDIPKMLDAE---------DIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAAN 260
            D+ E+   + K  D+E         D +   R  E+ I+   +SF  A +G  + E    
Sbjct: 1890 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1949

Query: 261  RICK----VLAVNQENE-------QLMEDYEKLASDLLEWIRRTIPWLEN--RVPENTMH 307
            RI       L   ++ E       QL  + E+   +  E +++++   E   R  +  + 
Sbjct: 1950 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2009

Query: 308  AMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRP---AFMPSEGRMVSDI 364
             +++      + RRL +  + +   QL++     Q +L+   +    A    E  +   +
Sbjct: 2010 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2069

Query: 365  NNAWGCLEQV-----------EKGYEEWLLNE------IRRLERLDHLAEKFRQKASIHE 407
                  L+Q+           E+  E  +  E       R++E  + L +   ++A    
Sbjct: 2070 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2129

Query: 408  AWTDGKEAMLRQKDYETATLSEI-KALLKKHEAFESDLAAHQDRVEQI----AAIAQELN 462
                  E + ++ + E A  ++  +A L++ +A ++++  H+   EQ     A + QEL 
Sbjct: 2130 QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2189

Query: 463  EL 464
             L
Sbjct: 2190 TL 2191


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score =  242 bits (617), Expect = 1e-63
 Identities = 147/396 (37%), Positives = 218/396 (55%), Gaps = 23/396 (5%)

Query: 30  EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHK 89
           ++ Q+KTFT W N HL KA   I ++ ED RDG  L+ LLEV+SG+ L + E+G+MR HK
Sbjct: 9   DRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFHK 67

Query: 90  ISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISV----EETS 145
           + NV  ALD++  + VKLV+I  ++I DGN K+TLG+IWTIIL F I DI V    E+ +
Sbjct: 68  LQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMT 127

Query: 146 AKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNL 205
           AKE LLLW QR    Y+ +   NF  SW+DG  F A+IHRH+P LID  K+ +   L NL
Sbjct: 128 AKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENL 187

Query: 206 NTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKV 265
           + AF VAE+ L + ++LD ED V   +PDEK+I+TYVSS Y A       +         
Sbjct: 188 DQAFSVAERDLGVTRLLDPED-VDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRA---- 242

Query: 266 LAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKP 325
                E +   ++Y +L   LL+W+R      E R   ++   ++     F  ++ +  P
Sbjct: 243 ----NELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELP 298

Query: 326 PKVQEKCQLEINFNTLQTKL---RLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWL 382
            K  +K + +  + +L+  +   +L   P + P       D+   WG L       E+ L
Sbjct: 299 AKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHP------LDVEKEWGKLHVAILEREKQL 352

Query: 383 LNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLR 418
            +E  RLE L  +  K + +A + E   +  +A+L+
Sbjct: 353 RSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQ 388



 Score = 34.3 bits (77), Expect = 0.53
 Identities = 60/293 (20%), Positives = 117/293 (39%), Gaps = 27/293 (9%)

Query: 254  KAETAANRICKVLAVNQENEQLMEDYEKLASDLLE---WIRRTIPWLENRVPENTMHAMQ 310
            KAE    +  K LA  Q   +L ED E++A  L E     +RT+     R  E +  A +
Sbjct: 2294 KAEAELLQQQKELAQEQAR-RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2352

Query: 311  QKL---EDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNA 367
             KL   E  R   R  +  +   K   EI     +T+L    +   + +           
Sbjct: 2353 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE--------- 2403

Query: 368  WGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASI-----HEAWTDGKEAMLRQKD- 421
               +++ +  ++   L E   +  L+   EK +Q+A +      E  T  +E +L++   
Sbjct: 2404 ---IQRQQSDHDAERLREA--IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2458

Query: 422  YETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICD 481
             + + LSE  +LL++    E + A  +   +   A AQ+L E        +    Q++  
Sbjct: 2459 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2518

Query: 482  QWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQD 534
              +       +  E + R ++ L+ ++Q   +  +  A  N  +   ++ L++
Sbjct: 2519 SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE 2571



 Score = 30.4 bits (67), Expect = 7.7
 Identities = 56/302 (18%), Positives = 118/302 (39%), Gaps = 47/302 (15%)

Query: 210  DVAEKYLDIPKMLDAE---------DIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAAN 260
            D+ E+   + K  D+E         D +   R  E+ I+   +SF  A +G  + E    
Sbjct: 1858 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1917

Query: 261  RICK----VLAVNQENE-------QLMEDYEKLASDLLEWIRRTIPWLEN--RVPENTMH 307
            RI       L   ++ E       QL  + E+   +  E +++++   E   R  +  + 
Sbjct: 1918 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 1977

Query: 308  AMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRP---AFMPSEGRMVSDI 364
             +++      + RRL +  + +   QL++     Q +L+   +    A    E  +   +
Sbjct: 1978 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2037

Query: 365  NNAWGCLEQV-----------EKGYEEWLLNE------IRRLERLDHLAEKFRQKASIHE 407
                  L+Q+           E+  E  +  E       R++E  + L +   ++A    
Sbjct: 2038 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2097

Query: 408  AWTDGKEAMLRQKDYETATLSEI-KALLKKHEAFESDLAAHQDRVEQI----AAIAQELN 462
                  E + ++ + E A  ++  +A L++ +A ++++  H+   EQ     A + QEL 
Sbjct: 2098 QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2157

Query: 463  EL 464
             L
Sbjct: 2158 TL 2159


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score =  242 bits (617), Expect = 1e-63
 Identities = 147/396 (37%), Positives = 218/396 (55%), Gaps = 23/396 (5%)

Query: 30  EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHK 89
           ++ Q+KTFT W N HL KA   I ++ ED RDG  L+ LLEV+SG+ L + E+G+MR HK
Sbjct: 178 DRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFHK 236

Query: 90  ISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISV----EETS 145
           + NV  ALD++  + VKLV+I  ++I DGN K+TLG+IWTIIL F I DI V    E+ +
Sbjct: 237 LQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMT 296

Query: 146 AKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNL 205
           AKE LLLW QR    Y+ +   NF  SW+DG  F A+IHRH+P LID  K+ +   L NL
Sbjct: 297 AKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENL 356

Query: 206 NTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKV 265
           + AF VAE+ L + ++LD ED V   +PDEK+I+TYVSS Y A       +         
Sbjct: 357 DQAFSVAERDLGVTRLLDPED-VDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRA---- 411

Query: 266 LAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKP 325
                E +   ++Y +L   LL+W+R      E R   ++   ++     F  ++ +  P
Sbjct: 412 ----NELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELP 467

Query: 326 PKVQEKCQLEINFNTLQTKL---RLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWL 382
            K  +K + +  + +L+  +   +L   P + P       D+   WG L       E+ L
Sbjct: 468 AKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHP------LDVEKEWGKLHVAILEREKQL 521

Query: 383 LNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLR 418
            +E  RLE L  +  K + +A + E   +  +A+L+
Sbjct: 522 RSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQ 557



 Score = 34.3 bits (77), Expect = 0.53
 Identities = 60/293 (20%), Positives = 117/293 (39%), Gaps = 27/293 (9%)

Query: 254  KAETAANRICKVLAVNQENEQLMEDYEKLASDLLE---WIRRTIPWLENRVPENTMHAMQ 310
            KAE    +  K LA  Q   +L ED E++A  L E     +RT+     R  E +  A +
Sbjct: 2463 KAEAELLQQQKELAQEQAR-RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2521

Query: 311  QKL---EDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNA 367
             KL   E  R   R  +  +   K   EI     +T+L    +   + +           
Sbjct: 2522 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE--------- 2572

Query: 368  WGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASI-----HEAWTDGKEAMLRQKD- 421
               +++ +  ++   L E   +  L+   EK +Q+A +      E  T  +E +L++   
Sbjct: 2573 ---IQRQQSDHDAERLREA--IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2627

Query: 422  YETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICD 481
             + + LSE  +LL++    E + A  +   +   A AQ+L E        +    Q++  
Sbjct: 2628 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2687

Query: 482  QWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQD 534
              +       +  E + R ++ L+ ++Q   +  +  A  N  +   ++ L++
Sbjct: 2688 SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE 2740



 Score = 30.4 bits (67), Expect = 7.7
 Identities = 56/302 (18%), Positives = 118/302 (39%), Gaps = 47/302 (15%)

Query: 210  DVAEKYLDIPKMLDAE---------DIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAAN 260
            D+ E+   + K  D+E         D +   R  E+ I+   +SF  A +G  + E    
Sbjct: 2027 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 2086

Query: 261  RICK----VLAVNQENE-------QLMEDYEKLASDLLEWIRRTIPWLEN--RVPENTMH 307
            RI       L   ++ E       QL  + E+   +  E +++++   E   R  +  + 
Sbjct: 2087 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2146

Query: 308  AMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRP---AFMPSEGRMVSDI 364
             +++      + RRL +  + +   QL++     Q +L+   +    A    E  +   +
Sbjct: 2147 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2206

Query: 365  NNAWGCLEQV-----------EKGYEEWLLNE------IRRLERLDHLAEKFRQKASIHE 407
                  L+Q+           E+  E  +  E       R++E  + L +   ++A    
Sbjct: 2207 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2266

Query: 408  AWTDGKEAMLRQKDYETATLSEI-KALLKKHEAFESDLAAHQDRVEQI----AAIAQELN 462
                  E + ++ + E A  ++  +A L++ +A ++++  H+   EQ     A + QEL 
Sbjct: 2267 QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2326

Query: 463  EL 464
             L
Sbjct: 2327 TL 2328


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score =  242 bits (617), Expect = 1e-63
 Identities = 147/396 (37%), Positives = 218/396 (55%), Gaps = 23/396 (5%)

Query: 30  EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHK 89
           ++ Q+KTFT W N HL KA   I ++ ED RDG  L+ LLEV+SG+ L + E+G+MR HK
Sbjct: 19  DRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFHK 77

Query: 90  ISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISV----EETS 145
           + NV  ALD++  + VKLV+I  ++I DGN K+TLG+IWTIIL F I DI V    E+ +
Sbjct: 78  LQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMT 137

Query: 146 AKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNL 205
           AKE LLLW QR    Y+ +   NF  SW+DG  F A+IHRH+P LID  K+ +   L NL
Sbjct: 138 AKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENL 197

Query: 206 NTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKV 265
           + AF VAE+ L + ++LD ED V   +PDEK+I+TYVSS Y A       +         
Sbjct: 198 DQAFSVAERDLGVTRLLDPED-VDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRA---- 252

Query: 266 LAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKP 325
                E +   ++Y +L   LL+W+R      E R   ++   ++     F  ++ +  P
Sbjct: 253 ----NELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELP 308

Query: 326 PKVQEKCQLEINFNTLQTKL---RLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWL 382
            K  +K + +  + +L+  +   +L   P + P       D+   WG L       E+ L
Sbjct: 309 AKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHP------LDVEKEWGKLHVAILEREKQL 362

Query: 383 LNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLR 418
            +E  RLE L  +  K + +A + E   +  +A+L+
Sbjct: 363 RSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQ 398



 Score = 34.3 bits (77), Expect = 0.53
 Identities = 60/293 (20%), Positives = 117/293 (39%), Gaps = 27/293 (9%)

Query: 254  KAETAANRICKVLAVNQENEQLMEDYEKLASDLLE---WIRRTIPWLENRVPENTMHAMQ 310
            KAE    +  K LA  Q   +L ED E++A  L E     +RT+     R  E +  A +
Sbjct: 2304 KAEAELLQQQKELAQEQAR-RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2362

Query: 311  QKL---EDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNA 367
             KL   E  R   R  +  +   K   EI     +T+L    +   + +           
Sbjct: 2363 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE--------- 2413

Query: 368  WGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASI-----HEAWTDGKEAMLRQKD- 421
               +++ +  ++   L E   +  L+   EK +Q+A +      E  T  +E +L++   
Sbjct: 2414 ---IQRQQSDHDAERLREA--IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2468

Query: 422  YETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICD 481
             + + LSE  +LL++    E + A  +   +   A AQ+L E        +    Q++  
Sbjct: 2469 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2528

Query: 482  QWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQD 534
              +       +  E + R ++ L+ ++Q   +  +  A  N  +   ++ L++
Sbjct: 2529 SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE 2581



 Score = 30.4 bits (67), Expect = 7.7
 Identities = 56/302 (18%), Positives = 118/302 (39%), Gaps = 47/302 (15%)

Query: 210  DVAEKYLDIPKMLDAE---------DIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAAN 260
            D+ E+   + K  D+E         D +   R  E+ I+   +SF  A +G  + E    
Sbjct: 1868 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1927

Query: 261  RICK----VLAVNQENE-------QLMEDYEKLASDLLEWIRRTIPWLEN--RVPENTMH 307
            RI       L   ++ E       QL  + E+   +  E +++++   E   R  +  + 
Sbjct: 1928 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 1987

Query: 308  AMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRP---AFMPSEGRMVSDI 364
             +++      + RRL +  + +   QL++     Q +L+   +    A    E  +   +
Sbjct: 1988 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2047

Query: 365  NNAWGCLEQV-----------EKGYEEWLLNE------IRRLERLDHLAEKFRQKASIHE 407
                  L+Q+           E+  E  +  E       R++E  + L +   ++A    
Sbjct: 2048 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2107

Query: 408  AWTDGKEAMLRQKDYETATLSEI-KALLKKHEAFESDLAAHQDRVEQI----AAIAQELN 462
                  E + ++ + E A  ++  +A L++ +A ++++  H+   EQ     A + QEL 
Sbjct: 2108 QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2167

Query: 463  EL 464
             L
Sbjct: 2168 TL 2169


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score =  242 bits (617), Expect = 1e-63
 Identities = 147/396 (37%), Positives = 218/396 (55%), Gaps = 23/396 (5%)

Query: 30  EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHK 89
           ++ Q+KTFT W N HL KA   I ++ ED RDG  L+ LLEV+SG+ L + E+G+MR HK
Sbjct: 27  DRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFHK 85

Query: 90  ISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISV----EETS 145
           + NV  ALD++  + VKLV+I  ++I DGN K+TLG+IWTIIL F I DI V    E+ +
Sbjct: 86  LQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMT 145

Query: 146 AKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNL 205
           AKE LLLW QR    Y+ +   NF  SW+DG  F A+IHRH+P LID  K+ +   L NL
Sbjct: 146 AKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENL 205

Query: 206 NTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKV 265
           + AF VAE+ L + ++LD ED V   +PDEK+I+TYVSS Y A       +         
Sbjct: 206 DQAFSVAERDLGVTRLLDPED-VDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRA---- 260

Query: 266 LAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKP 325
                E +   ++Y +L   LL+W+R      E R   ++   ++     F  ++ +  P
Sbjct: 261 ----NELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELP 316

Query: 326 PKVQEKCQLEINFNTLQTKL---RLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWL 382
            K  +K + +  + +L+  +   +L   P + P       D+   WG L       E+ L
Sbjct: 317 AKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHP------LDVEKEWGKLHVAILEREKQL 370

Query: 383 LNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLR 418
            +E  RLE L  +  K + +A + E   +  +A+L+
Sbjct: 371 RSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQ 406



 Score = 34.3 bits (77), Expect = 0.53
 Identities = 60/293 (20%), Positives = 117/293 (39%), Gaps = 27/293 (9%)

Query: 254  KAETAANRICKVLAVNQENEQLMEDYEKLASDLLE---WIRRTIPWLENRVPENTMHAMQ 310
            KAE    +  K LA  Q   +L ED E++A  L E     +RT+     R  E +  A +
Sbjct: 2312 KAEAELLQQQKELAQEQAR-RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2370

Query: 311  QKL---EDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNA 367
             KL   E  R   R  +  +   K   EI     +T+L    +   + +           
Sbjct: 2371 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE--------- 2421

Query: 368  WGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASI-----HEAWTDGKEAMLRQKD- 421
               +++ +  ++   L E   +  L+   EK +Q+A +      E  T  +E +L++   
Sbjct: 2422 ---IQRQQSDHDAERLREA--IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2476

Query: 422  YETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICD 481
             + + LSE  +LL++    E + A  +   +   A AQ+L E        +    Q++  
Sbjct: 2477 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2536

Query: 482  QWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQD 534
              +       +  E + R ++ L+ ++Q   +  +  A  N  +   ++ L++
Sbjct: 2537 SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE 2589



 Score = 30.4 bits (67), Expect = 7.7
 Identities = 56/302 (18%), Positives = 118/302 (39%), Gaps = 47/302 (15%)

Query: 210  DVAEKYLDIPKMLDAE---------DIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAAN 260
            D+ E+   + K  D+E         D +   R  E+ I+   +SF  A +G  + E    
Sbjct: 1876 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1935

Query: 261  RICK----VLAVNQENE-------QLMEDYEKLASDLLEWIRRTIPWLEN--RVPENTMH 307
            RI       L   ++ E       QL  + E+   +  E +++++   E   R  +  + 
Sbjct: 1936 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 1995

Query: 308  AMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRP---AFMPSEGRMVSDI 364
             +++      + RRL +  + +   QL++     Q +L+   +    A    E  +   +
Sbjct: 1996 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2055

Query: 365  NNAWGCLEQV-----------EKGYEEWLLNE------IRRLERLDHLAEKFRQKASIHE 407
                  L+Q+           E+  E  +  E       R++E  + L +   ++A    
Sbjct: 2056 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2115

Query: 408  AWTDGKEAMLRQKDYETATLSEI-KALLKKHEAFESDLAAHQDRVEQI----AAIAQELN 462
                  E + ++ + E A  ++  +A L++ +A ++++  H+   EQ     A + QEL 
Sbjct: 2116 QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2175

Query: 463  EL 464
             L
Sbjct: 2176 TL 2177


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score =  242 bits (617), Expect = 1e-63
 Identities = 147/396 (37%), Positives = 218/396 (55%), Gaps = 23/396 (5%)

Query: 30  EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHK 89
           ++ Q+KTFT W N HL KA   I ++ ED RDG  L+ LLEV+SG+ L + E+G+MR HK
Sbjct: 68  DRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFHK 126

Query: 90  ISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISV----EETS 145
           + NV  ALD++  + VKLV+I  ++I DGN K+TLG+IWTIIL F I DI V    E+ +
Sbjct: 127 LQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMT 186

Query: 146 AKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNL 205
           AKE LLLW QR    Y+ +   NF  SW+DG  F A+IHRH+P LID  K+ +   L NL
Sbjct: 187 AKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENL 246

Query: 206 NTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKV 265
           + AF VAE+ L + ++LD ED V   +PDEK+I+TYVSS Y A       +         
Sbjct: 247 DQAFSVAERDLGVTRLLDPED-VDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRA---- 301

Query: 266 LAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKP 325
                E +   ++Y +L   LL+W+R      E R   ++   ++     F  ++ +  P
Sbjct: 302 ----NELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELP 357

Query: 326 PKVQEKCQLEINFNTLQTKL---RLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWL 382
            K  +K + +  + +L+  +   +L   P + P       D+   WG L       E+ L
Sbjct: 358 AKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHP------LDVEKEWGKLHVAILEREKQL 411

Query: 383 LNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLR 418
            +E  RLE L  +  K + +A + E   +  +A+L+
Sbjct: 412 RSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQ 447



 Score = 34.3 bits (77), Expect = 0.53
 Identities = 60/293 (20%), Positives = 117/293 (39%), Gaps = 27/293 (9%)

Query: 254  KAETAANRICKVLAVNQENEQLMEDYEKLASDLLE---WIRRTIPWLENRVPENTMHAMQ 310
            KAE    +  K LA  Q   +L ED E++A  L E     +RT+     R  E +  A +
Sbjct: 2353 KAEAELLQQQKELAQEQAR-RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2411

Query: 311  QKL---EDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNA 367
             KL   E  R   R  +  +   K   EI     +T+L    +   + +           
Sbjct: 2412 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE--------- 2462

Query: 368  WGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASI-----HEAWTDGKEAMLRQKD- 421
               +++ +  ++   L E   +  L+   EK +Q+A +      E  T  +E +L++   
Sbjct: 2463 ---IQRQQSDHDAERLREA--IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2517

Query: 422  YETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICD 481
             + + LSE  +LL++    E + A  +   +   A AQ+L E        +    Q++  
Sbjct: 2518 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2577

Query: 482  QWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQD 534
              +       +  E + R ++ L+ ++Q   +  +  A  N  +   ++ L++
Sbjct: 2578 SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE 2630



 Score = 30.4 bits (67), Expect = 7.7
 Identities = 56/302 (18%), Positives = 118/302 (39%), Gaps = 47/302 (15%)

Query: 210  DVAEKYLDIPKMLDAE---------DIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAAN 260
            D+ E+   + K  D+E         D +   R  E+ I+   +SF  A +G  + E    
Sbjct: 1917 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1976

Query: 261  RICK----VLAVNQENE-------QLMEDYEKLASDLLEWIRRTIPWLEN--RVPENTMH 307
            RI       L   ++ E       QL  + E+   +  E +++++   E   R  +  + 
Sbjct: 1977 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2036

Query: 308  AMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRP---AFMPSEGRMVSDI 364
             +++      + RRL +  + +   QL++     Q +L+   +    A    E  +   +
Sbjct: 2037 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2096

Query: 365  NNAWGCLEQV-----------EKGYEEWLLNE------IRRLERLDHLAEKFRQKASIHE 407
                  L+Q+           E+  E  +  E       R++E  + L +   ++A    
Sbjct: 2097 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2156

Query: 408  AWTDGKEAMLRQKDYETATLSEI-KALLKKHEAFESDLAAHQDRVEQI----AAIAQELN 462
                  E + ++ + E A  ++  +A L++ +A ++++  H+   EQ     A + QEL 
Sbjct: 2157 QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2216

Query: 463  EL 464
             L
Sbjct: 2217 TL 2218


>gi|169218211 PREDICTED: similar to plectin 1, partial [Homo
           sapiens]
          Length = 1369

 Score =  238 bits (607), Expect = 2e-62
 Identities = 146/396 (36%), Positives = 216/396 (54%), Gaps = 23/396 (5%)

Query: 30  EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHK 89
           ++ Q+KT T W N HL KA   I ++ ED RDG  L+ LLEV+SG+ L + E+G+MR HK
Sbjct: 174 DRVQKKTSTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFHK 232

Query: 90  ISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISV----EETS 145
           + NV  ALD++  + VKLV+I  ++I DGN K+TLG+IWTIIL F I DI V    E+ +
Sbjct: 233 LQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMT 292

Query: 146 AKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNL 205
           AKE LLLW QR    Y+ +   NF  SW+DG  F A+IHRH+P LID  K+ +   L NL
Sbjct: 293 AKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENL 352

Query: 206 NTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKV 265
           + AF VAE+ L + ++LD ED V   +PDEK+I+TYVSS Y A       +         
Sbjct: 353 DQAFSVAERDLGVTRLLDPED-VDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRA---- 407

Query: 266 LAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKP 325
                E +   ++Y +L   LL+W+R      E R   ++   ++     F  ++ +  P
Sbjct: 408 ----NELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELP 463

Query: 326 PKVQEKCQLEINFNTLQTKL---RLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWL 382
            K  +K + +  + +L+  +   +L   P + P       D+   WG L       E+ L
Sbjct: 464 AKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHP------LDVEKEWGKLHVAILEREKQL 517

Query: 383 LNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLR 418
            +E  RLE L  +  K + +A + E      +A+L+
Sbjct: 518 RSEFERLECLQRIVTKLQMEAGLCEEQLHQADALLQ 553


>gi|221316624 dystonin isoform 4 [Homo sapiens]
          Length = 5526

 Score =  236 bits (603), Expect = 5e-62
 Identities = 141/382 (36%), Positives = 211/382 (55%), Gaps = 18/382 (4%)

Query: 30  EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHK 89
           +K Q+KTFT W N HL K    + ++ ED RDG  L+ LLEV+SG+ L + E+G+MR H+
Sbjct: 63  DKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPR-EKGRMRFHR 121

Query: 90  ISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISV----EETS 145
           + NV  ALD++  + VKLV+I  ++I DGN K+TLG+IWTIIL F I DI V    E+ S
Sbjct: 122 LQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESEDMS 181

Query: 146 AKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNL 205
           AKE LLLW Q+ T  Y  +  +NF   W+DG  F A+IH++RP+LID   +     L NL
Sbjct: 182 AKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANL 241

Query: 206 NTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKV 265
             AF VAEK + + ++LD ED V  + PDEK+++TYVSS Y AF    +           
Sbjct: 242 EHAFYVAEK-IGVIRLLDPED-VDVSSPDEKSVITYVSSLYDAFPKVPEGGEG------- 292

Query: 266 LAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKP 325
           +  N    + +E Y+ + + L++WIR  +  +  R   N    ++     +  ++    P
Sbjct: 293 IGANDVEVKWIE-YQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIP 351

Query: 326 PKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNE 385
           PK  EK +++  +  L+  +           +G   +DI   WG L       E+ L  E
Sbjct: 352 PKETEKSKIKRLYKLLEIWIEFGRIKLL---QGYHPNDIEKEWGKLIIAMLEREKALRPE 408

Query: 386 IRRLERLDHLAEKFRQKASIHE 407
           + RLE L  +A + ++ + I E
Sbjct: 409 VERLEMLQQIANRVQRDSVICE 430



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 102/488 (20%), Positives = 191/488 (39%), Gaps = 71/488 (14%)

Query: 197  RKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAE 256
            ++ +    +    D  ++ LDI   L +E I     PD+  +   +     A+    KA 
Sbjct: 4139 QQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAW 4198

Query: 257  TAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENT-MHAMQQKLED 315
               +RI K+    +E  Q    Y+     + +W+      L +  P  T +  ++Q++E+
Sbjct: 4199 K--DRIDKL----EEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEE 4252

Query: 316  FRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVE 375
             + ++         E  Q +I    L  +  L  +     S+   V D       L+ + 
Sbjct: 4253 LKQFK--------SEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLME---LKLIW 4301

Query: 376  KGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLK 435
               EE ++N   +LE       +F+       AW    E +L ++         I+  L 
Sbjct: 4302 DSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELA 4361

Query: 436  KHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRRE 495
            KH   ++D+ AHQ  VE +     +L E         ++  ++  +  + L  L Q+ + 
Sbjct: 4362 KHHVLQNDVLAHQSTVEAVNKAGNDLIE---------SSAGEEASNLQNKLEVLNQRWQN 4412

Query: 496  ALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFK 555
             LE+TE+  + +D   L  AK          G +EDLQ           Q LT       
Sbjct: 4413 VLEKTEQRKQQLDGA-LRQAK-------GFHGEIEDLQ-----------QWLTDTERHLL 4453

Query: 556  AT-----LPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQL 610
            A+     LP+  KE+   L +H EV    +      A    Y ++  +         +Q+
Sbjct: 4454 ASKPLGGLPETAKEQ---LNVHMEVCAAFE------AKEETYKSLMQKG--------QQM 4496

Query: 611  VPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSH 670
            + R  ++  E +  Q  N    K    +  +     +TK+EE   +++E H +L+D ++ 
Sbjct: 4497 LARCPKS-AETNIDQDINNLKEKWESVETKLNER--KTKLEEALNLAMEFHNSLQDFINW 4553

Query: 671  LRQYEKSI 678
            L Q E+++
Sbjct: 4554 LTQAEQTL 4561



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 77/405 (19%), Positives = 170/405 (41%), Gaps = 45/405 (11%)

Query: 376  KGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLK 435
            K  E+   N ++ L+     + +F+Q +   +AW D K+    +    +A L  +++L+K
Sbjct: 2771 KDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIK 2830

Query: 436  KHEAFESDLAAHQDRVEQIAAIAQE-LNELDYYDSPSVNARCQKICDQWDNLGALTQKRR 494
             H+ F   L A     E+  A  +  L +    +  ++  +   I   WD         +
Sbjct: 2831 DHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTF------NK 2884

Query: 495  EALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQF 554
            +  ER  KL E++++  L+Y ++      W++    +L++  I   ++  +G     E  
Sbjct: 2885 QVKERENKLKESLEKA-LKYKEQVETLWPWIDKCQNNLEE--IKFCLDPAEG-----ENS 2936

Query: 555  KATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGK--WDHVRQLVP 612
             A L    KE     G+            V +      + ++  EI+ +   D  + L+ 
Sbjct: 2937 IAKLKSLQKEMDQHFGM------------VELLNNTANSLLSVCEIDKEVVTDENKSLIQ 2984

Query: 613  RRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQ----- 667
            + D    + H+++   E + ++F     V       +  +  +  +++H +L  Q     
Sbjct: 2985 KVDMVTEQLHSKKFCLENMTQKFKEFQEVSKE--SKRQLQCAKEQLDIHDSLGSQAYSNK 3042

Query: 668  -LSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALI--FDNKHTNYTMEHIRVGWEQLLTTI 724
             L+ L+  +KS+   K ++D  +   +L Q+ ++   D+K T+  +  +     Q  +T+
Sbjct: 3043 YLTMLQTQQKSLQALKHQVDLAK---RLAQDLVVEASDSKGTSDVLLQVET-IAQEHSTL 3098

Query: 725  ARTINEVENQILTR-DAKGISQEQMNEFRASFNHFDRDHSGTLGP 768
            ++ ++E  + + T+    G  Q  + E  + F  FD D   ++ P
Sbjct: 3099 SQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFD-DELDSMAP 3142



 Score = 33.9 bits (76), Expect = 0.69
 Identities = 70/328 (21%), Positives = 123/328 (37%), Gaps = 33/328 (10%)

Query: 371  LEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHE---AWTDGKEAMLRQKDYETATL 427
            LE ++  Y++         + L+   +  R+  S HE    W D  E  L    YET   
Sbjct: 3636 LEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLS--YETQ-- 3691

Query: 428  SEIKALLKKHEAFESDLAAHQDRVE--QIAAIAQELNELDYYDSPSVNARCQKICDQWDN 485
                 +LK  EA ++ +   + + E     A+   LNE+        +A  + +   W  
Sbjct: 3692 -----VLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVS-------SALLELV--PWRA 3737

Query: 486  LGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQ 545
               L +   E  ER   + +TI Q   E    AA   +       D + ++I  T +++ 
Sbjct: 3738 REGLEKMVAEDNERYRLVSDTITQKVEEID--AAILRSQQFDQAADAELSWITETEKKLM 3795

Query: 546  GL---TTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEING 602
             L       +Q  A L       + IL   + +  +V++ H  M   +       Q +  
Sbjct: 3796 SLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEK---QSMKK 3852

Query: 603  KWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEM-- 660
            K D V +      Q  +E + + +  + L  QF      + PW+      I ++      
Sbjct: 3853 KLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALE 3912

Query: 661  HGTLEDQLSHLRQYEKSIVNYKPKIDQL 688
            + TL  Q    RQ  + I  +KP ID++
Sbjct: 3913 YETLRQQQEEHRQLRELIAEHKPHIDKM 3940



 Score = 33.5 bits (75), Expect = 0.90
 Identities = 23/89 (25%), Positives = 40/89 (44%), Gaps = 4/89 (4%)

Query: 380  EWLLNEI----RRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLK 435
            E LLN+     R+LE +  +A++F +       W    E  L   +      S+++  + 
Sbjct: 3426 EALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIA 3485

Query: 436  KHEAFESDLAAHQDRVEQIAAIAQELNEL 464
            +H+A E D+  H   + Q  +I Q L  L
Sbjct: 3486 QHKALEDDIINHNKHLHQAVSIGQSLKVL 3514



 Score = 33.5 bits (75), Expect = 0.90
 Identities = 37/165 (22%), Positives = 64/165 (38%), Gaps = 39/165 (23%)

Query: 408  AWTDGKEAMLRQKDYETAT--LSEIKALLKKHEAFESDLAAHQDRVEQI----------- 454
            AW    E  L  KD E     + E+KAL+ +H+ F  ++   Q  V+++           
Sbjct: 4988 AWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADP 5047

Query: 455  AAIAQELNELD-------------YYDSPS------VNARCQKICDQWDNLGALTQKRR- 494
            +++   +  LD              Y S S       N R   +  +W  +  L  +RR 
Sbjct: 5048 SSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRR 5107

Query: 495  ---EALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTF 536
               +AL+R E+L E  +  +  + K+   +  WM      + D F
Sbjct: 5108 KLNDALDRLEELREFANFDFDIWRKK---YMRWMNHKKSRVMDFF 5149



 Score = 32.3 bits (72), Expect = 2.0
 Identities = 18/63 (28%), Positives = 33/63 (52%), Gaps = 6/63 (9%)

Query: 649  KMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKP------KIDQLEGDHQLIQEALIFD 702
            ++E I  ++ + H TLE     L   EK +VN +P      K+++    H+ +++ +I  
Sbjct: 3438 QLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINH 3497

Query: 703  NKH 705
            NKH
Sbjct: 3498 NKH 3500


>gi|221316622 dystonin isoform 3 [Homo sapiens]
          Length = 5537

 Score =  236 bits (603), Expect = 5e-62
 Identities = 141/382 (36%), Positives = 211/382 (55%), Gaps = 18/382 (4%)

Query: 30  EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHK 89
           +K Q+KTFT W N HL K    + ++ ED RDG  L+ LLEV+SG+ L + E+G+MR H+
Sbjct: 74  DKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPR-EKGRMRFHR 132

Query: 90  ISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISV----EETS 145
           + NV  ALD++  + VKLV+I  ++I DGN K+TLG+IWTIIL F I DI V    E+ S
Sbjct: 133 LQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESEDMS 192

Query: 146 AKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNL 205
           AKE LLLW Q+ T  Y  +  +NF   W+DG  F A+IH++RP+LID   +     L NL
Sbjct: 193 AKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANL 252

Query: 206 NTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKV 265
             AF VAEK + + ++LD ED V  + PDEK+++TYVSS Y AF    +           
Sbjct: 253 EHAFYVAEK-IGVIRLLDPED-VDVSSPDEKSVITYVSSLYDAFPKVPEGGEG------- 303

Query: 266 LAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKP 325
           +  N    + +E Y+ + + L++WIR  +  +  R   N    ++     +  ++    P
Sbjct: 304 IGANDVEVKWIE-YQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIP 362

Query: 326 PKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNE 385
           PK  EK +++  +  L+  +           +G   +DI   WG L       E+ L  E
Sbjct: 363 PKETEKSKIKRLYKLLEIWIEFGRIKLL---QGYHPNDIEKEWGKLIIAMLEREKALRPE 419

Query: 386 IRRLERLDHLAEKFRQKASIHE 407
           + RLE L  +A + ++ + I E
Sbjct: 420 VERLEMLQQIANRVQRDSVICE 441



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 102/488 (20%), Positives = 191/488 (39%), Gaps = 71/488 (14%)

Query: 197  RKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAE 256
            ++ +    +    D  ++ LDI   L +E I     PD+  +   +     A+    KA 
Sbjct: 4150 QQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAW 4209

Query: 257  TAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENT-MHAMQQKLED 315
               +RI K+    +E  Q    Y+     + +W+      L +  P  T +  ++Q++E+
Sbjct: 4210 K--DRIDKL----EEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEE 4263

Query: 316  FRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVE 375
             + ++         E  Q +I    L  +  L  +     S+   V D       L+ + 
Sbjct: 4264 LKQFK--------SEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLME---LKLIW 4312

Query: 376  KGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLK 435
               EE ++N   +LE       +F+       AW    E +L ++         I+  L 
Sbjct: 4313 DSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELA 4372

Query: 436  KHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRRE 495
            KH   ++D+ AHQ  VE +     +L E         ++  ++  +  + L  L Q+ + 
Sbjct: 4373 KHHVLQNDVLAHQSTVEAVNKAGNDLIE---------SSAGEEASNLQNKLEVLNQRWQN 4423

Query: 496  ALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFK 555
             LE+TE+  + +D   L  AK          G +EDLQ           Q LT       
Sbjct: 4424 VLEKTEQRKQQLDGA-LRQAK-------GFHGEIEDLQ-----------QWLTDTERHLL 4464

Query: 556  AT-----LPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQL 610
            A+     LP+  KE+   L +H EV    +      A    Y ++  +         +Q+
Sbjct: 4465 ASKPLGGLPETAKEQ---LNVHMEVCAAFE------AKEETYKSLMQKG--------QQM 4507

Query: 611  VPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSH 670
            + R  ++  E +  Q  N    K    +  +     +TK+EE   +++E H +L+D ++ 
Sbjct: 4508 LARCPKS-AETNIDQDINNLKEKWESVETKLNER--KTKLEEALNLAMEFHNSLQDFINW 4564

Query: 671  LRQYEKSI 678
            L Q E+++
Sbjct: 4565 LTQAEQTL 4572



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 77/405 (19%), Positives = 170/405 (41%), Gaps = 45/405 (11%)

Query: 376  KGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLK 435
            K  E+   N ++ L+     + +F+Q +   +AW D K+    +    +A L  +++L+K
Sbjct: 2782 KDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIK 2841

Query: 436  KHEAFESDLAAHQDRVEQIAAIAQE-LNELDYYDSPSVNARCQKICDQWDNLGALTQKRR 494
             H+ F   L A     E+  A  +  L +    +  ++  +   I   WD         +
Sbjct: 2842 DHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTF------NK 2895

Query: 495  EALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQF 554
            +  ER  KL E++++  L+Y ++      W++    +L++  I   ++  +G     E  
Sbjct: 2896 QVKERENKLKESLEKA-LKYKEQVETLWPWIDKCQNNLEE--IKFCLDPAEG-----ENS 2947

Query: 555  KATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGK--WDHVRQLVP 612
             A L    KE     G+            V +      + ++  EI+ +   D  + L+ 
Sbjct: 2948 IAKLKSLQKEMDQHFGM------------VELLNNTANSLLSVCEIDKEVVTDENKSLIQ 2995

Query: 613  RRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQ----- 667
            + D    + H+++   E + ++F     V       +  +  +  +++H +L  Q     
Sbjct: 2996 KVDMVTEQLHSKKFCLENMTQKFKEFQEVSKE--SKRQLQCAKEQLDIHDSLGSQAYSNK 3053

Query: 668  -LSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALI--FDNKHTNYTMEHIRVGWEQLLTTI 724
             L+ L+  +KS+   K ++D  +   +L Q+ ++   D+K T+  +  +     Q  +T+
Sbjct: 3054 YLTMLQTQQKSLQALKHQVDLAK---RLAQDLVVEASDSKGTSDVLLQVET-IAQEHSTL 3109

Query: 725  ARTINEVENQILTR-DAKGISQEQMNEFRASFNHFDRDHSGTLGP 768
            ++ ++E  + + T+    G  Q  + E  + F  FD D   ++ P
Sbjct: 3110 SQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFD-DELDSMAP 3153



 Score = 33.9 bits (76), Expect = 0.69
 Identities = 70/328 (21%), Positives = 123/328 (37%), Gaps = 33/328 (10%)

Query: 371  LEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHE---AWTDGKEAMLRQKDYETATL 427
            LE ++  Y++         + L+   +  R+  S HE    W D  E  L    YET   
Sbjct: 3647 LEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLS--YETQ-- 3702

Query: 428  SEIKALLKKHEAFESDLAAHQDRVE--QIAAIAQELNELDYYDSPSVNARCQKICDQWDN 485
                 +LK  EA ++ +   + + E     A+   LNE+        +A  + +   W  
Sbjct: 3703 -----VLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVS-------SALLELV--PWRA 3748

Query: 486  LGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQ 545
               L +   E  ER   + +TI Q   E    AA   +       D + ++I  T +++ 
Sbjct: 3749 REGLEKMVAEDNERYRLVSDTITQKVEEID--AAILRSQQFDQAADAELSWITETEKKLM 3806

Query: 546  GL---TTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEING 602
             L       +Q  A L       + IL   + +  +V++ H  M   +       Q +  
Sbjct: 3807 SLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEK---QSMKK 3863

Query: 603  KWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEM-- 660
            K D V +      Q  +E + + +  + L  QF      + PW+      I ++      
Sbjct: 3864 KLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALE 3923

Query: 661  HGTLEDQLSHLRQYEKSIVNYKPKIDQL 688
            + TL  Q    RQ  + I  +KP ID++
Sbjct: 3924 YETLRQQQEEHRQLRELIAEHKPHIDKM 3951



 Score = 33.5 bits (75), Expect = 0.90
 Identities = 23/89 (25%), Positives = 40/89 (44%), Gaps = 4/89 (4%)

Query: 380  EWLLNEI----RRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLK 435
            E LLN+     R+LE +  +A++F +       W    E  L   +      S+++  + 
Sbjct: 3437 EALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIA 3496

Query: 436  KHEAFESDLAAHQDRVEQIAAIAQELNEL 464
            +H+A E D+  H   + Q  +I Q L  L
Sbjct: 3497 QHKALEDDIINHNKHLHQAVSIGQSLKVL 3525



 Score = 33.5 bits (75), Expect = 0.90
 Identities = 37/165 (22%), Positives = 64/165 (38%), Gaps = 39/165 (23%)

Query: 408  AWTDGKEAMLRQKDYETAT--LSEIKALLKKHEAFESDLAAHQDRVEQI----------- 454
            AW    E  L  KD E     + E+KAL+ +H+ F  ++   Q  V+++           
Sbjct: 4999 AWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADP 5058

Query: 455  AAIAQELNELD-------------YYDSPS------VNARCQKICDQWDNLGALTQKRR- 494
            +++   +  LD              Y S S       N R   +  +W  +  L  +RR 
Sbjct: 5059 SSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRR 5118

Query: 495  ---EALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTF 536
               +AL+R E+L E  +  +  + K+   +  WM      + D F
Sbjct: 5119 KLNDALDRLEELREFANFDFDIWRKK---YMRWMNHKKSRVMDFF 5160



 Score = 32.3 bits (72), Expect = 2.0
 Identities = 18/63 (28%), Positives = 33/63 (52%), Gaps = 6/63 (9%)

Query: 649  KMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKP------KIDQLEGDHQLIQEALIFD 702
            ++E I  ++ + H TLE     L   EK +VN +P      K+++    H+ +++ +I  
Sbjct: 3449 QLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINH 3508

Query: 703  NKH 705
            NKH
Sbjct: 3509 NKH 3511


>gi|221316618 dystonin isoform 2 [Homo sapiens]
          Length = 5675

 Score =  236 bits (603), Expect = 5e-62
 Identities = 141/382 (36%), Positives = 211/382 (55%), Gaps = 18/382 (4%)

Query: 30  EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHK 89
           +K Q+KTFT W N HL K    + ++ ED RDG  L+ LLEV+SG+ L + E+G+MR H+
Sbjct: 212 DKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPR-EKGRMRFHR 270

Query: 90  ISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISV----EETS 145
           + NV  ALD++  + VKLV+I  ++I DGN K+TLG+IWTIIL F I DI V    E+ S
Sbjct: 271 LQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESEDMS 330

Query: 146 AKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNL 205
           AKE LLLW Q+ T  Y  +  +NF   W+DG  F A+IH++RP+LID   +     L NL
Sbjct: 331 AKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANL 390

Query: 206 NTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKV 265
             AF VAEK + + ++LD ED V  + PDEK+++TYVSS Y AF    +           
Sbjct: 391 EHAFYVAEK-IGVIRLLDPED-VDVSSPDEKSVITYVSSLYDAFPKVPEGGEG------- 441

Query: 266 LAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKP 325
           +  N    + +E Y+ + + L++WIR  +  +  R   N    ++     +  ++    P
Sbjct: 442 IGANDVEVKWIE-YQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIP 500

Query: 326 PKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNE 385
           PK  EK +++  +  L+  +           +G   +DI   WG L       E+ L  E
Sbjct: 501 PKETEKSKIKRLYKLLEIWIEFGRIKLL---QGYHPNDIEKEWGKLIIAMLEREKALRPE 557

Query: 386 IRRLERLDHLAEKFRQKASIHE 407
           + RLE L  +A + ++ + I E
Sbjct: 558 VERLEMLQQIANRVQRDSVICE 579



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 102/488 (20%), Positives = 191/488 (39%), Gaps = 71/488 (14%)

Query: 197  RKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAE 256
            ++ +    +    D  ++ LDI   L +E I     PD+  +   +     A+    KA 
Sbjct: 4288 QQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAW 4347

Query: 257  TAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENT-MHAMQQKLED 315
               +RI K+    +E  Q    Y+     + +W+      L +  P  T +  ++Q++E+
Sbjct: 4348 K--DRIDKL----EEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEE 4401

Query: 316  FRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVE 375
             + ++         E  Q +I    L  +  L  +     S+   V D       L+ + 
Sbjct: 4402 LKQFK--------SEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLME---LKLIW 4450

Query: 376  KGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLK 435
               EE ++N   +LE       +F+       AW    E +L ++         I+  L 
Sbjct: 4451 DSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELA 4510

Query: 436  KHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRRE 495
            KH   ++D+ AHQ  VE +     +L E         ++  ++  +  + L  L Q+ + 
Sbjct: 4511 KHHVLQNDVLAHQSTVEAVNKAGNDLIE---------SSAGEEASNLQNKLEVLNQRWQN 4561

Query: 496  ALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFK 555
             LE+TE+  + +D   L  AK          G +EDLQ           Q LT       
Sbjct: 4562 VLEKTEQRKQQLDGA-LRQAK-------GFHGEIEDLQ-----------QWLTDTERHLL 4602

Query: 556  AT-----LPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQL 610
            A+     LP+  KE+   L +H EV    +      A    Y ++  +         +Q+
Sbjct: 4603 ASKPLGGLPETAKEQ---LNVHMEVCAAFE------AKEETYKSLMQKG--------QQM 4645

Query: 611  VPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSH 670
            + R  ++  E +  Q  N    K    +  +     +TK+EE   +++E H +L+D ++ 
Sbjct: 4646 LARCPKS-AETNIDQDINNLKEKWESVETKLNER--KTKLEEALNLAMEFHNSLQDFINW 4702

Query: 671  LRQYEKSI 678
            L Q E+++
Sbjct: 4703 LTQAEQTL 4710



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 77/405 (19%), Positives = 170/405 (41%), Gaps = 45/405 (11%)

Query: 376  KGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLK 435
            K  E+   N ++ L+     + +F+Q +   +AW D K+    +    +A L  +++L+K
Sbjct: 2920 KDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIK 2979

Query: 436  KHEAFESDLAAHQDRVEQIAAIAQE-LNELDYYDSPSVNARCQKICDQWDNLGALTQKRR 494
             H+ F   L A     E+  A  +  L +    +  ++  +   I   WD         +
Sbjct: 2980 DHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTF------NK 3033

Query: 495  EALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQF 554
            +  ER  KL E++++  L+Y ++      W++    +L++  I   ++  +G     E  
Sbjct: 3034 QVKERENKLKESLEKA-LKYKEQVETLWPWIDKCQNNLEE--IKFCLDPAEG-----ENS 3085

Query: 555  KATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGK--WDHVRQLVP 612
             A L    KE     G+            V +      + ++  EI+ +   D  + L+ 
Sbjct: 3086 IAKLKSLQKEMDQHFGM------------VELLNNTANSLLSVCEIDKEVVTDENKSLIQ 3133

Query: 613  RRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQ----- 667
            + D    + H+++   E + ++F     V       +  +  +  +++H +L  Q     
Sbjct: 3134 KVDMVTEQLHSKKFCLENMTQKFKEFQEVSKE--SKRQLQCAKEQLDIHDSLGSQAYSNK 3191

Query: 668  -LSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALI--FDNKHTNYTMEHIRVGWEQLLTTI 724
             L+ L+  +KS+   K ++D  +   +L Q+ ++   D+K T+  +  +     Q  +T+
Sbjct: 3192 YLTMLQTQQKSLQALKHQVDLAK---RLAQDLVVEASDSKGTSDVLLQVET-IAQEHSTL 3247

Query: 725  ARTINEVENQILTR-DAKGISQEQMNEFRASFNHFDRDHSGTLGP 768
            ++ ++E  + + T+    G  Q  + E  + F  FD D   ++ P
Sbjct: 3248 SQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFD-DELDSMAP 3291



 Score = 33.9 bits (76), Expect = 0.69
 Identities = 70/328 (21%), Positives = 123/328 (37%), Gaps = 33/328 (10%)

Query: 371  LEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHE---AWTDGKEAMLRQKDYETATL 427
            LE ++  Y++         + L+   +  R+  S HE    W D  E  L    YET   
Sbjct: 3785 LEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLS--YETQ-- 3840

Query: 428  SEIKALLKKHEAFESDLAAHQDRVE--QIAAIAQELNELDYYDSPSVNARCQKICDQWDN 485
                 +LK  EA ++ +   + + E     A+   LNE+        +A  + +   W  
Sbjct: 3841 -----VLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVS-------SALLELV--PWRA 3886

Query: 486  LGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQ 545
               L +   E  ER   + +TI Q   E    AA   +       D + ++I  T +++ 
Sbjct: 3887 REGLEKMVAEDNERYRLVSDTITQKVEEID--AAILRSQQFDQAADAELSWITETEKKLM 3944

Query: 546  GL---TTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEING 602
             L       +Q  A L       + IL   + +  +V++ H  M   +       Q +  
Sbjct: 3945 SLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEK---QSMKK 4001

Query: 603  KWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEM-- 660
            K D V +      Q  +E + + +  + L  QF      + PW+      I ++      
Sbjct: 4002 KLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALE 4061

Query: 661  HGTLEDQLSHLRQYEKSIVNYKPKIDQL 688
            + TL  Q    RQ  + I  +KP ID++
Sbjct: 4062 YETLRQQQEEHRQLRELIAEHKPHIDKM 4089



 Score = 33.5 bits (75), Expect = 0.90
 Identities = 23/89 (25%), Positives = 40/89 (44%), Gaps = 4/89 (4%)

Query: 380  EWLLNEI----RRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLK 435
            E LLN+     R+LE +  +A++F +       W    E  L   +      S+++  + 
Sbjct: 3575 EALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIA 3634

Query: 436  KHEAFESDLAAHQDRVEQIAAIAQELNEL 464
            +H+A E D+  H   + Q  +I Q L  L
Sbjct: 3635 QHKALEDDIINHNKHLHQAVSIGQSLKVL 3663



 Score = 33.5 bits (75), Expect = 0.90
 Identities = 37/165 (22%), Positives = 64/165 (38%), Gaps = 39/165 (23%)

Query: 408  AWTDGKEAMLRQKDYETAT--LSEIKALLKKHEAFESDLAAHQDRVEQI----------- 454
            AW    E  L  KD E     + E+KAL+ +H+ F  ++   Q  V+++           
Sbjct: 5137 AWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADP 5196

Query: 455  AAIAQELNELD-------------YYDSPS------VNARCQKICDQWDNLGALTQKRR- 494
            +++   +  LD              Y S S       N R   +  +W  +  L  +RR 
Sbjct: 5197 SSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRR 5256

Query: 495  ---EALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTF 536
               +AL+R E+L E  +  +  + K+   +  WM      + D F
Sbjct: 5257 KLNDALDRLEELREFANFDFDIWRKK---YMRWMNHKKSRVMDFF 5298



 Score = 32.3 bits (72), Expect = 2.0
 Identities = 18/63 (28%), Positives = 33/63 (52%), Gaps = 6/63 (9%)

Query: 649  KMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKP------KIDQLEGDHQLIQEALIFD 702
            ++E I  ++ + H TLE     L   EK +VN +P      K+++    H+ +++ +I  
Sbjct: 3587 QLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINH 3646

Query: 703  NKH 705
            NKH
Sbjct: 3647 NKH 3649


>gi|34577047 dystonin isoform 1 [Homo sapiens]
          Length = 5497

 Score =  236 bits (603), Expect = 5e-62
 Identities = 141/382 (36%), Positives = 211/382 (55%), Gaps = 18/382 (4%)

Query: 30  EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHK 89
           +K Q+KTFT W N HL K    + ++ ED RDG  L+ LLEV+SG+ L + E+G+MR H+
Sbjct: 34  DKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPR-EKGRMRFHR 92

Query: 90  ISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISV----EETS 145
           + NV  ALD++  + VKLV+I  ++I DGN K+TLG+IWTIIL F I DI V    E+ S
Sbjct: 93  LQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESEDMS 152

Query: 146 AKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNL 205
           AKE LLLW Q+ T  Y  +  +NF   W+DG  F A+IH++RP+LID   +     L NL
Sbjct: 153 AKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANL 212

Query: 206 NTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKV 265
             AF VAEK + + ++LD ED V  + PDEK+++TYVSS Y AF    +           
Sbjct: 213 EHAFYVAEK-IGVIRLLDPED-VDVSSPDEKSVITYVSSLYDAFPKVPEGGEG------- 263

Query: 266 LAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKP 325
           +  N    + +E Y+ + + L++WIR  +  +  R   N    ++     +  ++    P
Sbjct: 264 IGANDVEVKWIE-YQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIP 322

Query: 326 PKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNE 385
           PK  EK +++  +  L+  +           +G   +DI   WG L       E+ L  E
Sbjct: 323 PKETEKSKIKRLYKLLEIWIEFGRIKLL---QGYHPNDIEKEWGKLIIAMLEREKALRPE 379

Query: 386 IRRLERLDHLAEKFRQKASIHE 407
           + RLE L  +A + ++ + I E
Sbjct: 380 VERLEMLQQIANRVQRDSVICE 401



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 102/488 (20%), Positives = 191/488 (39%), Gaps = 71/488 (14%)

Query: 197  RKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAE 256
            ++ +    +    D  ++ LDI   L +E I     PD+  +   +     A+    KA 
Sbjct: 4110 QQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAW 4169

Query: 257  TAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENT-MHAMQQKLED 315
               +RI K+    +E  Q    Y+     + +W+      L +  P  T +  ++Q++E+
Sbjct: 4170 K--DRIDKL----EEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEE 4223

Query: 316  FRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVE 375
             + ++         E  Q +I    L  +  L  +     S+   V D       L+ + 
Sbjct: 4224 LKQFK--------SEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLME---LKLIW 4272

Query: 376  KGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLK 435
               EE ++N   +LE       +F+       AW    E +L ++         I+  L 
Sbjct: 4273 DSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELA 4332

Query: 436  KHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRRE 495
            KH   ++D+ AHQ  VE +     +L E         ++  ++  +  + L  L Q+ + 
Sbjct: 4333 KHHVLQNDVLAHQSTVEAVNKAGNDLIE---------SSAGEEASNLQNKLEVLNQRWQN 4383

Query: 496  ALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFK 555
             LE+TE+  + +D   L  AK          G +EDLQ           Q LT       
Sbjct: 4384 VLEKTEQRKQQLDGA-LRQAK-------GFHGEIEDLQ-----------QWLTDTERHLL 4424

Query: 556  AT-----LPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQL 610
            A+     LP+  KE+   L +H EV    +      A    Y ++  +         +Q+
Sbjct: 4425 ASKPLGGLPETAKEQ---LNVHMEVCAAFE------AKEETYKSLMQKG--------QQM 4467

Query: 611  VPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSH 670
            + R  ++  E +  Q  N    K    +  +     +TK+EE   +++E H +L+D ++ 
Sbjct: 4468 LARCPKS-AETNIDQDINNLKEKWESVETKLNER--KTKLEEALNLAMEFHNSLQDFINW 4524

Query: 671  LRQYEKSI 678
            L Q E+++
Sbjct: 4525 LTQAEQTL 4532



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 77/405 (19%), Positives = 170/405 (41%), Gaps = 45/405 (11%)

Query: 376  KGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLK 435
            K  E+   N ++ L+     + +F+Q +   +AW D K+    +    +A L  +++L+K
Sbjct: 2742 KDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIK 2801

Query: 436  KHEAFESDLAAHQDRVEQIAAIAQE-LNELDYYDSPSVNARCQKICDQWDNLGALTQKRR 494
             H+ F   L A     E+  A  +  L +    +  ++  +   I   WD         +
Sbjct: 2802 DHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTF------NK 2855

Query: 495  EALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQF 554
            +  ER  KL E++++  L+Y ++      W++    +L++  I   ++  +G     E  
Sbjct: 2856 QVKERENKLKESLEKA-LKYKEQVETLWPWIDKCQNNLEE--IKFCLDPAEG-----ENS 2907

Query: 555  KATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGK--WDHVRQLVP 612
             A L    KE     G+            V +      + ++  EI+ +   D  + L+ 
Sbjct: 2908 IAKLKSLQKEMDQHFGM------------VELLNNTANSLLSVCEIDKEVVTDENKSLIQ 2955

Query: 613  RRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQ----- 667
            + D    + H+++   E + ++F     V       +  +  +  +++H +L  Q     
Sbjct: 2956 KVDMVTEQLHSKKFCLENMTQKFKEFQEVSKE--SKRQLQCAKEQLDIHDSLGSQAYSNK 3013

Query: 668  -LSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALI--FDNKHTNYTMEHIRVGWEQLLTTI 724
             L+ L+  +KS+   K ++D  +   +L Q+ ++   D+K T+  +  +     Q  +T+
Sbjct: 3014 YLTMLQTQQKSLQALKHQVDLAK---RLAQDLVVEASDSKGTSDVLLQVET-IAQEHSTL 3069

Query: 725  ARTINEVENQILTR-DAKGISQEQMNEFRASFNHFDRDHSGTLGP 768
            ++ ++E  + + T+    G  Q  + E  + F  FD D   ++ P
Sbjct: 3070 SQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFD-DELDSMAP 3113



 Score = 33.9 bits (76), Expect = 0.69
 Identities = 70/328 (21%), Positives = 123/328 (37%), Gaps = 33/328 (10%)

Query: 371  LEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHE---AWTDGKEAMLRQKDYETATL 427
            LE ++  Y++         + L+   +  R+  S HE    W D  E  L    YET   
Sbjct: 3607 LEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLS--YETQ-- 3662

Query: 428  SEIKALLKKHEAFESDLAAHQDRVE--QIAAIAQELNELDYYDSPSVNARCQKICDQWDN 485
                 +LK  EA ++ +   + + E     A+   LNE+        +A  + +   W  
Sbjct: 3663 -----VLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVS-------SALLELV--PWRA 3708

Query: 486  LGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQ 545
               L +   E  ER   + +TI Q   E    AA   +       D + ++I  T +++ 
Sbjct: 3709 REGLEKMVAEDNERYRLVSDTITQKVEEID--AAILRSQQFDQAADAELSWITETEKKLM 3766

Query: 546  GL---TTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEING 602
             L       +Q  A L       + IL   + +  +V++ H  M   +       Q +  
Sbjct: 3767 SLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEK---QSMKK 3823

Query: 603  KWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEM-- 660
            K D V +      Q  +E + + +  + L  QF      + PW+      I ++      
Sbjct: 3824 KLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALE 3883

Query: 661  HGTLEDQLSHLRQYEKSIVNYKPKIDQL 688
            + TL  Q    RQ  + I  +KP ID++
Sbjct: 3884 YETLRQQQEEHRQLRELIAEHKPHIDKM 3911



 Score = 33.5 bits (75), Expect = 0.90
 Identities = 23/89 (25%), Positives = 40/89 (44%), Gaps = 4/89 (4%)

Query: 380  EWLLNEI----RRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLK 435
            E LLN+     R+LE +  +A++F +       W    E  L   +      S+++  + 
Sbjct: 3397 EALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIA 3456

Query: 436  KHEAFESDLAAHQDRVEQIAAIAQELNEL 464
            +H+A E D+  H   + Q  +I Q L  L
Sbjct: 3457 QHKALEDDIINHNKHLHQAVSIGQSLKVL 3485



 Score = 33.5 bits (75), Expect = 0.90
 Identities = 37/165 (22%), Positives = 64/165 (38%), Gaps = 39/165 (23%)

Query: 408  AWTDGKEAMLRQKDYETAT--LSEIKALLKKHEAFESDLAAHQDRVEQI----------- 454
            AW    E  L  KD E     + E+KAL+ +H+ F  ++   Q  V+++           
Sbjct: 4959 AWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADP 5018

Query: 455  AAIAQELNELD-------------YYDSPS------VNARCQKICDQWDNLGALTQKRR- 494
            +++   +  LD              Y S S       N R   +  +W  +  L  +RR 
Sbjct: 5019 SSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRR 5078

Query: 495  ---EALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTF 536
               +AL+R E+L E  +  +  + K+   +  WM      + D F
Sbjct: 5079 KLNDALDRLEELREFANFDFDIWRKK---YMRWMNHKKSRVMDFF 5120



 Score = 32.3 bits (72), Expect = 2.0
 Identities = 18/63 (28%), Positives = 33/63 (52%), Gaps = 6/63 (9%)

Query: 649  KMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKP------KIDQLEGDHQLIQEALIFD 702
            ++E I  ++ + H TLE     L   EK +VN +P      K+++    H+ +++ +I  
Sbjct: 3409 QLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINH 3468

Query: 703  NKH 705
            NKH
Sbjct: 3469 NKH 3471


>gi|33188445 microfilament and actin filament cross-linker protein
           isoform a [Homo sapiens]
          Length = 5430

 Score =  226 bits (577), Expect = 6e-59
 Identities = 158/483 (32%), Positives = 251/483 (51%), Gaps = 46/483 (9%)

Query: 21  RDLLLDPAW----------EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLE 70
           +D +LDPA           ++ Q+KTFT W N HL K    I ++ ED RDG  L+ LLE
Sbjct: 58  QDSVLDPAERAVVRVADERDRVQKKTFTKWVNKHLMKVRKHINDLYEDLRDGHNLISLLE 117

Query: 71  VISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTI 130
           V+SG +L + E+G+MR H++ NV  ALDF+  + VKLV+I  ++I DGN K+TLG+IWTI
Sbjct: 118 VLSGIKLPR-EKGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTI 176

Query: 131 ILRFAIQDISVE----ETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRH 186
           IL F I DI +     + SAKE LLLW Q+ TA Y  +   NF   W DG  F ALIHR+
Sbjct: 177 ILHFQISDIYISGESGDMSAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIHRY 236

Query: 187 RPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFY 246
           RP+L+D  +++      NL  AF+VAE+ L + ++LDAED V    PDEK+++TYVSS Y
Sbjct: 237 RPDLVDMERVQIQSNRENLEQAFEVAER-LGVTRLLDAED-VDVPSPDEKSVITYVSSIY 294

Query: 247 HAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRR-TIPWLENRVPENT 305
            AF    +     +          E +   ++Y+     L+ WI++ TI   +   P+N 
Sbjct: 295 DAFPKVPEGGEGISA--------TEVDSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNP 346

Query: 306 MHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDIN 365
           +  ++     +  ++      K +EK ++E  +  L+  +           +G   +D+ 
Sbjct: 347 VE-LKALYNQYIHFKETEILAKEREKGRIEELYKLLEVWIEFGR---IKLPQGYHPNDVE 402

Query: 366 NAWG--CLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYE 423
             WG   +E +E+  E+ L   + RLE L  +A K +  A       + +E +   K+  
Sbjct: 403 EEWGKLIIEMLER--EKSLRPAVERLELLLQIANKIQNGA------LNCEEKLTLAKNTL 454

Query: 424 TATLSEIKALLKKHEAFESDLAAH----QDRVEQIAAIAQELNELDYYDSPSVNARCQKI 479
            A  + +++   +    ESD+  +    +  + Q+    Q L + +YY    +  R  ++
Sbjct: 455 QADAAHLES--GQPVQCESDVIMYIQECEGLIRQLQVDLQILRDENYYQLEELAFRVMRL 512

Query: 480 CDQ 482
            D+
Sbjct: 513 QDE 515



 Score = 50.1 bits (118), Expect = 9e-06
 Identities = 98/511 (19%), Positives = 202/511 (39%), Gaps = 64/511 (12%)

Query: 279  YEKLASDLLEWIRRTIPWLENRVPENTM-HAMQQKLEDFRDYRRLHKPPKVQEKCQLEIN 337
            Y++L  DL E +R     L  +   +T   A++Q+LE+  + R         +  QL+  
Sbjct: 2626 YQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIR--------SDLEQLDHE 2677

Query: 338  FNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAE 397
                QT   L +  + +  E  +  ++      +    +G E+   + I RL+      +
Sbjct: 2678 VKEAQT---LCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQ 2734

Query: 398  KFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAI 457
            +F+Q       W D K++   +    +A L  +++ L+++E F+  L  H    E I A 
Sbjct: 2735 QFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAE 2794

Query: 458  AQE--LNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYA 515
             +   L+     +  ++  +  ++ + W+ L   T  R+  L+   +      Q Y  + 
Sbjct: 2795 GESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKA----QKYQWHV 2850

Query: 516  KRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEV 575
            +   P   W+E     + +  +  T++ +Q L ++  + KA L + +K R ++L I N  
Sbjct: 2851 EDLVP---WIEDCKAKMSELRV--TLDPVQ-LESSLLRSKAMLNEVEKRR-SLLEILNSA 2903

Query: 576  SKIV--------QTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQ------ALTEE 621
            + I+               AG N       +E+  K   + ++  R  +       + ++
Sbjct: 2904 ADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKK 2963

Query: 622  HARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNY 681
                +H   +    G+QA         K  E  R   E+   LE Q+ +LR + + +V  
Sbjct: 2964 VEGAKHQLEIFDALGSQA------CSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVED 3017

Query: 682  KP---------------KIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIAR 726
             P               + + LE   ++    ++ +NK       H RV   ++ + +A 
Sbjct: 3018 APDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRV--REMFSQLAD 3075

Query: 727  TINEVENQ-ILTRDAKGISQEQMNEFRASFN 756
              +E++    + RD   + Q Q+ + R   N
Sbjct: 3076 LDDELDGMGAIGRDTDSL-QSQIEDVRLFLN 3105



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 54/298 (18%), Positives = 122/298 (40%), Gaps = 29/298 (9%)

Query: 210  DVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVN 269
            D   + L+  ++L A+ I      ++  +   +    +A+    K  T   R+ K+    
Sbjct: 4097 DGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNK--TWKERLEKL---- 4150

Query: 270  QENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENT-MHAMQQKLEDFRD-----YRRLH 323
            ++  Q    Y+     + +W+  T+  L    P  T ++ ++ +L + ++     Y++  
Sbjct: 4151 EDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQI 4210

Query: 324  KPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLL 383
            +  K+  + +L +   T +T   +   P         ++++ + W  L +     +  L 
Sbjct: 4211 EMEKLNHQGELMLKKATDETDRDIIREP---------LTELKHLWENLGEKIAHRQHKLE 4261

Query: 384  NEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESD 443
              +  L +  H  E+         +W    E +L  +   +     I+  L KH   ++D
Sbjct: 4262 GALLALGQFQHALEELM-------SWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKND 4314

Query: 444  LAAHQDRVEQIAAIAQELNELDY-YDSPSVNARCQKICDQWDNLGALTQKRREALERT 500
            + AHQ  VE +     EL E     D+ S+ +R + +   W+++   T++R + L+ T
Sbjct: 4315 VLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQST 4372



 Score = 43.9 bits (102), Expect = 7e-04
 Identities = 100/558 (17%), Positives = 214/558 (38%), Gaps = 79/558 (14%)

Query: 226  DIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASD 285
            +I GT   ++K ++             +K E+   +   +  +N E    +E  + L + 
Sbjct: 3779 EIFGTCGEEQKTVLQ------------EKTESLIQQYEAISLLNSERYARLERAQVLVNQ 3826

Query: 286  LLEWIRRTIPWLEN-----------RVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQL 334
              E      PW+E             +    +   Q+++   R+    HK P + +  ++
Sbjct: 3827 FWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHK-PHIDKLLKI 3885

Query: 335  EINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIR-RLERLD 393
                  L             P EG MV +        ++ E  Y + +  E+R R   LD
Sbjct: 3886 GPQLKELN------------PEEGEMVEE------KYQKAENMYAQ-IKEEVRQRALALD 3926

Query: 394  HLAEKFRQKASIHE------AWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAH 447
                +  Q    H+         +   + LR      A + +I+  +  +++   +L   
Sbjct: 3927 EAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKL 3986

Query: 448  QDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQK-RREALERTEKLLET 506
            Q   E +    +EL  +        +   ++I D+ D +    +  +  A ER  K L+ 
Sbjct: 3987 QPSFEALKRRGEEL--IGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDV 4044

Query: 507  IDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERL 566
            ++     +   AA     +   ++D QD  IVH +E   G+  +  + +    +  KE  
Sbjct: 4045 LELAEKFWYDMAA-----LLTTIKDTQD--IVHDLES-PGIDPSIIKQQVEAAETIKEET 4096

Query: 567  AILGIHNEVS--KIVQTYHVNMAG--TNPYTTITPQEINGKWDHVRQLVPRRDQALTEE- 621
               G+H E+   +I+    +   G    P    +  E+N  W+++ +    R + L +  
Sbjct: 4097 D--GLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAM 4154

Query: 622  HARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNY 681
             A  Q+ + L+  F    N +      K+  +  +  +++ T++DQL+ +++++  +   
Sbjct: 4155 QAAVQYQDTLQAMFDWLDNTV-----IKLCTMPPVGTDLN-TVKDQLNEMKEFKVEVYQQ 4208

Query: 682  KPKIDQL--EGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRD 739
            + ++++L  +G+  L +     D       +  ++  WE L   IA   +++E  +L   
Sbjct: 4209 QIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALL--- 4265

Query: 740  AKGISQEQMNEFRASFNH 757
            A G  Q  + E  +   H
Sbjct: 4266 ALGQFQHALEELMSWLTH 4283



 Score = 43.9 bits (102), Expect = 7e-04
 Identities = 78/405 (19%), Positives = 146/405 (36%), Gaps = 64/405 (15%)

Query: 264  KVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLH 323
            KV+  + E  + ++D  K A    E  ++ I WLE+         +  +LE   D  ++ 
Sbjct: 4576 KVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESH-----LDSELEISNDPDKIK 4630

Query: 324  KPPKVQEKCQLEIN-----FNTLQTKLRLSNRPAFMPSEGR----MVSDINNAWG--CLE 372
                  ++ Q  +      ++T     R       +P + +     + ++ + W   C +
Sbjct: 4631 LQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGK 4690

Query: 373  QVEKGY--EEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEI 430
             VE+ +  EE LL   + ++ L  L +           W    E  L +       L  +
Sbjct: 4691 SVERQHKLEEALLFSGQFMDALQALVD-----------WLYKVEPQLAEDQPVHGDLDLV 4739

Query: 431  KALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALT 490
              L+  H+ F+ +L      V+ +    +EL E    D+  V  + Q++  +WD +  L+
Sbjct: 4740 MNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLS 4799

Query: 491  QKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTA 550
              ++  LE+  K  E                           +DT  VH + E       
Sbjct: 4800 VSKQSRLEQALKQAEVF-------------------------RDT--VHMLLEWLSEAEQ 4832

Query: 551  HEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNM-----AGTNPYTTITPQEINGKWD 605
              +F+  LPD  +   +++  H E  K V+   V++      G        P  I     
Sbjct: 4833 TLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKH 4892

Query: 606  HVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIG---PWIQ 647
             +  +  R ++ LT     QQ  E    +  A A ++     WIQ
Sbjct: 4893 WITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQ 4937



 Score = 39.3 bits (90), Expect = 0.016
 Identities = 54/248 (21%), Positives = 99/248 (39%), Gaps = 20/248 (8%)

Query: 303  ENTMHAMQQKLEDFRDYRRLHKPPKVQEKC-QLEINFNTLQTKLRLSNRPA---FMPSEG 358
            ++ +  +   L D  +     KPP  + K  + +I    L  +L L +R A    + +EG
Sbjct: 3283 QDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRL-LDDRKATVDMLQAEG 3341

Query: 359  RMVS------DINNAWGCLEQVEKGYEEWLLNEIRRLERLDH---LAEKFRQKASIHEAW 409
              ++      D     G LE +E  + E L     R ++L+    LA++F + A     +
Sbjct: 3342 GRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDF 3401

Query: 410  TDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDS 469
                E  L   +      ++I+  + +H+A E D+  H   V Q   I Q L+ L    S
Sbjct: 3402 LSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSL---TS 3458

Query: 470  PSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAM 529
            P   A    + ++ D+L A   + ++   R   LL+        + +      NW+    
Sbjct: 3459 P---AEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVE 3515

Query: 530  EDLQDTFI 537
            + L   F+
Sbjct: 3516 DKLSSVFV 3523



 Score = 38.9 bits (89), Expect = 0.022
 Identities = 65/326 (19%), Positives = 130/326 (39%), Gaps = 61/326 (18%)

Query: 253  QKAETAANRICKVLAVNQEN-EQLMEDYEKLASD---LLEWIRRTIPWLENR--VPENTM 306
            Q+  T  + +CK+    Q   EQ ++  E        LLEW+      L  R  +P++T 
Sbjct: 4786 QELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDT- 4844

Query: 307  HAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINN 366
             A+Q  ++  +++ +     KV+EK ++++N      ++ L+            ++ I +
Sbjct: 4845 EALQSLIDTHKEFMK-----KVEEK-RVDVNSAVAMGEVILA------VCHPDCITTIKH 4892

Query: 367  AWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHE---AWTDGKEAMLRQKDYE 423
             W  +  +   +EE L    +  +RL+    +    A + E   AW    E  L Q+D E
Sbjct: 4893 -W--ITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQE 4949

Query: 424  TA--TLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYY-------------- 467
                 +  +KAL+ +H+ F  ++   Q  V+++    +  N    +              
Sbjct: 4950 PIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKS 5009

Query: 468  -------------DSPSVNARCQKICDQWDNLGALTQKRR----EALERTEKLLETIDQL 510
                          S + N R  ++  +W  +  L  +R+    +AL+R E+L E  +  
Sbjct: 5010 LSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELKEFANFD 5069

Query: 511  YLEYAKRAAPFNNWMEGAMEDLQDTF 536
            +  + K+   +  WM      + D F
Sbjct: 5070 FDVWRKK---YMRWMNHKKSRVMDFF 5092



 Score = 37.7 bits (86), Expect = 0.048
 Identities = 36/181 (19%), Positives = 75/181 (41%), Gaps = 19/181 (10%)

Query: 482  QWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTI 541
            +++ LG +  +R+E+L+     +E       E  K A     W+E   E L+    + + 
Sbjct: 2378 KYEKLGGVLHERQESLQAILNRME-------EVHKEANSVLQWLESKEEVLKSMDAMSSP 2430

Query: 542  EEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEIN 601
             + + +    E  KA L + ++    I  +   ++ ++ TY  +    N       +E+N
Sbjct: 2431 TKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAEN--WKKIQEELN 2488

Query: 602  GKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTK---MEEIGRISI 658
             +W+   ++   R + L E  +           F A  + + PW+  K   M  +G +SI
Sbjct: 2489 SRWERATEVTVARQRQLEESASH-------LACFQAAESQLRPWLMEKELMMGVLGPLSI 2541

Query: 659  E 659
            +
Sbjct: 2542 D 2542



 Score = 37.0 bits (84), Expect = 0.082
 Identities = 65/330 (19%), Positives = 127/330 (38%), Gaps = 38/330 (11%)

Query: 371  LEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWT------DGKEAMLRQKDYET 424
            L  V+  +E+ +   I R   LD   ++ +Q    HEAW       +  E+ L  +   +
Sbjct: 4567 LVSVQSRWEKVVQRSIERGRSLDDARKRAKQ---FHEAWKKLIDWLEDAESHLDSELEIS 4623

Query: 425  ATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNE--LDYYDSPSVNARCQKICDQ 482
                +IK  L KH+ F+  L   Q   +      + L E  L   DS  ++    ++ D+
Sbjct: 4624 NDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDK 4683

Query: 483  WDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVH-TI 541
            WD +   + +R+  LE  E LL        ++        +W+      L +   VH  +
Sbjct: 4684 WDTVCGKSVERQHKLE--EALL-----FSGQFMDALQALVDWLYKVEPQLAEDQPVHGDL 4736

Query: 542  EEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEIN 601
            + +  L  AH+ F+  L    K    +  +     ++++    N      +     QE++
Sbjct: 4737 DLVMNLMDAHKVFQKEL---GKRTGTVQVLKRSGRELIE----NSRDDTTWVKGQLQELS 4789

Query: 602  GKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMH 661
             +WD V +L   +   L  E A +Q      + F    +++  W+    +     ++   
Sbjct: 4790 TRWDTVCKLSVSKQSRL--EQALKQ-----AEVFRDTVHMLLEWLSEAEQ-----TLRFR 4837

Query: 662  GTLEDQLSHLRQYEKSIVNYKPKIDQLEGD 691
            G L D    L+    +   +  K+++   D
Sbjct: 4838 GALPDDTEALQSLIDTHKEFMKKVEEKRVD 4867



 Score = 35.4 bits (80), Expect = 0.24
 Identities = 43/253 (16%), Positives = 97/253 (38%), Gaps = 16/253 (6%)

Query: 264  KVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLH 323
            K L   ++  QL   ++    +L  W+R      E            +++  F+  ++  
Sbjct: 3594 KALRTLEQARQLATKFQSTYEELTGWLREVE---EELATSGGQSPTGEQIPQFQQRQKEL 3650

Query: 324  KPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEG--RMVSDINNAWGCLEQVEKGYEEW 381
            K   ++ +  L+      +  L L     +   EG  ++VSD N  +       K   + 
Sbjct: 3651 KKEVMEHRLVLDTVNEVSRALLELV---PWRAREGLDKLVSDANEQY-------KLVSDT 3700

Query: 382  LLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFE 441
            +   +  ++     ++++ Q A    AW    +  L           +  A L+  +AF 
Sbjct: 3701 IGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFS 3760

Query: 442  SDLAAHQDRVEQIAAIAQELNELDYYDSPSV-NARCQKICDQWDNLGALTQKRREALERT 500
             D+  H+D ++++ +   E+      +  +V   + + +  Q++ +  L  +R   LER 
Sbjct: 3761 IDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERA 3820

Query: 501  EKLLETIDQLYLE 513
            + L+    + Y E
Sbjct: 3821 QVLVNQFWETYEE 3833



 Score = 34.3 bits (77), Expect = 0.53
 Identities = 38/229 (16%), Positives = 91/229 (39%), Gaps = 13/229 (5%)

Query: 248  AFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMH 307
            A + A + ET  ++  K LA N++    + D+          +   +P +E     +   
Sbjct: 1660 AVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEK 1719

Query: 308  AMQQKLEDFRDYRRLHKPPKVQEKCQL------EINFNTLQTKLRLSNRPAFMPSEGRMV 361
                  + +    +   P K+ ++C++      E+        L   +  AF+   G  +
Sbjct: 1720 GALDTTDGYMGVNQA--PEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNL 1777

Query: 362  SDINNAW--GCLEQVEKGYEEWLLN---EIRRLERLDHLAEKFRQKASIHEAWTDGKEAM 416
            +          L ++++ Y   L     E+++++ L    +KF Q     E+W +  E  
Sbjct: 1778 TPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKE 1837

Query: 417  LRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELD 465
            L       ++   + +LLK+  +F  D+ +H+  +  +    Q++ +++
Sbjct: 1838 LENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDME 1886



 Score = 33.5 bits (75), Expect = 0.90
 Identities = 98/521 (18%), Positives = 200/521 (38%), Gaps = 70/521 (13%)

Query: 210  DVAEKYLDIPKML----DAEDIVGTARPDEKAIMTYVSSFYHAFSG-----AQKAETAAN 260
            ++AE  + + K+     D  +I G   PD + +     S    F       A+++     
Sbjct: 1983 ELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQK 2042

Query: 261  RICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYR 320
             I +  +V +  E L++   ++  +L     + +  L + V +  +    +  +D     
Sbjct: 2043 AIAQSQSVQESLESLLQSIGEVEQNLEG---KQVSSLSSGVIQEALATNMKLKQDI---- 2095

Query: 321  RLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWG--CLEQVEKGY 378
                    ++K  LE     +   +  ++       +G++ ++++  +   CL+Q EK  
Sbjct: 2096 -------ARQKSSLEATREMVTRFMETADSTTAAVLQGKL-AEVSQRFEQLCLQQQEK-- 2145

Query: 379  EEWLLNEIRRLERLDHLAEKFRQ---------------KASIHEAWTDGKEAMLRQKDYE 423
            E  L   + + E  +HL+ K +Q                  I   +   +E  L  +D +
Sbjct: 2146 ESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQ 2205

Query: 424  TATLSEIKALLKKHEA--FESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICD 481
               L  ++ L+ +  +  F  DL  HQDRV+ +     EL +    +     + CQ+  D
Sbjct: 2206 E-NLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQK-TVKEREKDASSCQEQLD 2263

Query: 482  QWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHT- 540
            ++  L    QK  +  E +    ET        +  A      +E     L D     T 
Sbjct: 2264 EFRKLVRTFQKWLKETEGSIPPTET--------SMSAKELEKQIEHLKSLLDDWASKGTL 2315

Query: 541  IEEIQGLTTAHEQ--FKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQ 598
            +EEI    T+ E    + T PD+  +  +IL         V  YH     T     ++  
Sbjct: 2316 VEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMS-- 2373

Query: 599  EINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISI 658
            ++N K++ +  ++  R ++L    A     E + K    +AN +  W+++K E +  +  
Sbjct: 2374 DVNLKYEKLGGVLHERQESL---QAILNRMEEVHK----EANSVLQWLESKEEVLKSMDA 2426

Query: 659  EMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEAL 699
                T  + +    +  K+   +  +++Q     Q ++EAL
Sbjct: 2427 MSSPTKTETVKAQAESNKA---FLAELEQNSPKIQKVKEAL 2464


>gi|115298659 spectrin, alpha, erythrocytic 1 [Homo sapiens]
          Length = 2419

 Score =  219 bits (558), Expect = 9e-57
 Identities = 136/503 (27%), Positives = 254/503 (50%), Gaps = 18/503 (3%)

Query: 393  DHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAA-HQDRV 451
            D+  ++F  KA + EAW   KE  L+      A L +   LL K +  ++ L +  Q+R+
Sbjct: 1927 DYAFQEFNWKADVVEAWIADKETSLKTNG-NGADLGDFLTLLAKQDTLDASLQSFQQERL 1985

Query: 452  EQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLY 511
             +I  +  +L    +  S ++  R   +  +W+ L   +   R+ L   +  L+  + L+
Sbjct: 1986 PEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLF 2045

Query: 512  LEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGI 571
            +E+A +A+  NNW E   E+L +     ++ EI+ L   HE F A+L  A  +   +L +
Sbjct: 2046 VEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLLEL 2105

Query: 572  HNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERL 631
              ++  +          ++PYT +T + +   W H+  ++  R+Q L +E ARQ  N  +
Sbjct: 2106 DQQIKAL-------GVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEM 2158

Query: 632  RKQFGAQANVIGPWI-QTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEG 690
             ++F   A+    WI +T+   +    ++  GTLE QL   ++ +K I   K ++ ++  
Sbjct: 2159 CQEFEQNASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVD 2218

Query: 691  DHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNE 750
                +++ALI D K   Y+   +   W+QL     R  + +E QI  +D KG+S+E + E
Sbjct: 2219 LGDNLEDALILDIK---YSTIGLAQQWDQLYQLGLRMQHNLEQQIQAKDIKGVSEETLKE 2275

Query: 751  FRASFNHFDRDHSGTLGPEEFKACLISLGY--DIGNDPQGEAEFARIMSIVDPNRLGVVT 808
            F   + HFD + +G L  +EF++CL  L Y   +  + + E +F + +  VDP R G V+
Sbjct: 2276 FSTIYKHFDENLTGRLTHKEFRSCLRGLNYYLPMVEEDEHEPKFEKFLDAVDPGRKGYVS 2335

Query: 809  FQAFIDFM-SRETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMAPY 867
             + +  F+  +E+ +  ++D++  +F+ LA  K+YIT +++++ L P+Q  +C   M  Y
Sbjct: 2336 LEDYTAFLIDKESENIKSSDEIENAFQALAEGKSYITKEDMKQALTPEQVSFCATHMQQY 2395

Query: 868  TGP--DSVPGALDYMSFSTALYG 888
              P   S     DY+ F+ + +G
Sbjct: 2396 MDPRGRSHLSGYDYVGFTNSYFG 2418



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 97/489 (19%), Positives = 193/489 (39%), Gaps = 84/489 (17%)

Query: 253  QKAETAANRICKVL-AVNQENEQLMEDYEKL-----ASDLLEWIRRTIPWLENRVPENT- 305
            Q+ E   N+   +L    +   +L++ Y +      A D+LEWI       + +  ENT 
Sbjct: 1055 QRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWI-------QEKKAENTG 1107

Query: 306  -----MHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPA-------- 352
                 +  +Q+K ++F+                   + NT + +LR  N+ A        
Sbjct: 1108 VELDDVWELQKKFDEFQK------------------DLNTNEPRLRDINKVADDLLFEGL 1149

Query: 353  FMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDG 412
              P   ++  ++N+ WG L++        L +E R+L    H  E F ++A   +   + 
Sbjct: 1150 LTPEGAQIRQELNSRWGSLQR--------LADEQRQLLGSAHAVEVFHREADDTKEQIEK 1201

Query: 413  KEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSV 472
            K   L   D   + L  ++AL ++HE FE DL    D+V  +   A+ L+E     +  +
Sbjct: 1202 KCQALSAAD-PGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDL 1260

Query: 473  NARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDL 532
              +  ++ + W++L   T+ R+E+L   +K        YL +  +A    NW+      +
Sbjct: 1261 QRQKMELNEAWEDLQGRTKDRKESLNEAQK-------FYL-FLSKARDLQNWISSIGGMV 1312

Query: 533  QDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPY 592
                +   +  I+ L   H++ +A   D + E      + +  ++++ + H      +P 
Sbjct: 1313 SSQELAEDLTGIEILLERHQEHRA---DMEAEAPTFQALEDFSAELIDSGH----HASPE 1365

Query: 593  TTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEE 652
                 Q +  + D + +   +R + L +    Q         F    + +  W+  +   
Sbjct: 1366 IEKKLQAVKLERDDLEKAWEKRKKILDQCLELQ--------MFQGNCDQVESWMVARENS 1417

Query: 653  IGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEH 712
            +         +LE  +      +K+I   + KI  LE       E+LI D    +Y  E 
Sbjct: 1418 LRSDDKSSLDSLEALMKKRDDLDKAITAQEGKITDLEH----FAESLIADE---HYAKEE 1470

Query: 713  IRVGWEQLL 721
            I    +++L
Sbjct: 1471 IATRLQRVL 1479



 Score = 57.0 bits (136), Expect = 8e-08
 Identities = 54/234 (23%), Positives = 95/234 (40%), Gaps = 35/234 (14%)

Query: 277 EDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLE- 335
           + Y +  +D+LEWI                 A+   +E   D+ R     K  E  Q+E 
Sbjct: 161 QQYVQECADILEWI-------------GDKEAIATSVELGEDWERTEVLHKKFEDFQVEL 207

Query: 336 -------INFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRR 388
                  +  N    +    N P  +P      +++N AW  L  +           ++R
Sbjct: 208 VAKEGRVVEVNQYANECAEENHPD-LPLIQSKQNEVNAAWERLRGLA----------LQR 256

Query: 389 LERLDHLAEKFRQKASIHEA--WTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAA 446
            + L + A   R K  + EA  W   KE +L  +DY    ++  + L   H+  E +LA 
Sbjct: 257 QKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVAS-EGLFHSHKGLERNLAV 315

Query: 447 HQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERT 500
             D+V+++ A A++L      D+P +    + +   W+++ AL   R E L+ T
Sbjct: 316 MSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQAT 369



 Score = 54.7 bits (130), Expect = 4e-07
 Identities = 32/140 (22%), Positives = 66/140 (47%), Gaps = 10/140 (7%)

Query: 387 RRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAA 446
           RRL +   L +K  + +   + W + K+ +   +DY+   +  +K+ ++K + FE +LA 
Sbjct: 575 RRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDYKD--IQNLKSRVQKQQVFEKELAV 632

Query: 447 HQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLET 506
           ++ ++E I    QE+ E  +Y S +V  R  ++   W+ L   T+++   L    +    
Sbjct: 633 NKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQ---- 688

Query: 507 IDQLYLEYAKRAAPFNNWME 526
                L++   A     W+E
Sbjct: 689 ----QLQFENNAEDLQRWLE 704



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 46/186 (24%), Positives = 85/186 (45%), Gaps = 6/186 (3%)

Query: 314 EDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQ 373
           ED++D + L    + Q+  + E+  N  Q +  +      M   G   SD  N    L +
Sbjct: 608 EDYKDIQNLKSRVQKQQVFEKELAVNKTQLE-NIQKTGQEMIEGGHYASD--NVTTRLSE 664

Query: 374 VEKGYEEWLLNEIRRLERLDHLAEK--FRQKASIHEAWTDGKEAMLRQKDYETATLSEIK 431
           V   +EE L    ++  +L    ++  F   A   + W +  E  +  +DY    L+E++
Sbjct: 665 VASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKG-LAEVQ 723

Query: 432 ALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQ 491
             L+KH   ES +AA QD+V+ +  +A    E+ + DS  + AR + +  +++ L     
Sbjct: 724 NRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLA 783

Query: 492 KRREAL 497
            R++ L
Sbjct: 784 TRKKKL 789



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 60/277 (21%), Positives = 112/277 (40%), Gaps = 42/277 (15%)

Query: 407 EAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDY 466
           ++W   +EA L  +D   + L   +ALL+KHE FE    A ++++  +   A +L   D+
Sbjct: 489 DSWMSRQEAFLENEDLGNS-LGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDH 547

Query: 467 YDSPSVNARCQKICDQWDNLGALTQKRREALERT---EKLLETIDQLYLEYAKRAAPFNN 523
           YDS ++ A    +  + D L      RR  L+ +   +KL E  D L            N
Sbjct: 548 YDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDL-----------KN 596

Query: 524 WMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYH 583
           W+    +   D       ++IQ L +  ++ +    +    +  +  I     ++++  H
Sbjct: 597 WINKKKKLADD----EDYKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGH 652

Query: 584 VNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIG 643
              A  N  T ++  E+   W+ + +         T++   Q H    + QF   A  + 
Sbjct: 653 --YASDNVTTRLS--EVASLWEELLE--------ATKQKGTQLHEANQQLQFENNAEDLQ 700

Query: 644 PWI-----QTKMEEIGRISIEM------HGTLEDQLS 669
            W+     Q   E+ G+   E+      HG LE  ++
Sbjct: 701 RWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVA 737



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 51/254 (20%), Positives = 104/254 (40%), Gaps = 25/254 (9%)

Query: 398  KFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAI 457
            +F Q     E+W + K   +  +DY    L  ++ LLKKH+  E +L AH+  ++ +  +
Sbjct: 1717 QFFQDLDDEESWIEEKLIRVSSQDYGR-DLQGVQNLLKKHKRLEGELVAHEPAIQNVLDM 1775

Query: 458  AQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKR 517
            A++L +        +  R  +  + W+ L  L + R   LE + +        YL++ + 
Sbjct: 1776 AEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLE--------YLQFMQN 1827

Query: 518  AAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFK--ATLPDADKERLAILGIHNEV 575
            A     W+              T+   Q L   HE  +    + +   + +   G  + +
Sbjct: 1828 AEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQG-EDIL 1886

Query: 576  SKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQF 635
            +K++Q    N            +EI+ K + + +  P   +A+      Q  ++   ++F
Sbjct: 1887 NKVLQEESQN------------KEISSKIEALNEKTPSLAKAIA-AWKLQLEDDYAFQEF 1933

Query: 636  GAQANVIGPWIQTK 649
              +A+V+  WI  K
Sbjct: 1934 NWKADVVEAWIADK 1947



 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 47/265 (17%), Positives = 109/265 (41%), Gaps = 29/265 (10%)

Query: 372  EQVEKGYEEWLLNEIRRLERLDHLAE--KFRQKASIHEAWTDGKEAMLRQKDYETATLSE 429
            + +EK +E       +R + LD   E   F+      E+W   +E  LR  D   ++L  
Sbjct: 1378 DDLEKAWE-------KRKKILDQCLELQMFQGNCDQVESWMVARENSLRSDD--KSSLDS 1428

Query: 430  IKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGAL 489
            ++AL+KK +  +  + A + ++  +   A+ L   ++Y    +  R Q++ D+W  L A 
Sbjct: 1429 LEALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKA- 1487

Query: 490  TQKRREALERTEKL--LETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGL 547
                 + ++   KL     + Q Y +  +        +E  + ++  T    + ++   +
Sbjct: 1488 -----QLIDERTKLGDYANLKQFYRDLEE--------LEEWISEMLPTACDESYKDATNI 1534

Query: 548  TTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHV 607
               + + +    + D     + G+ N  + +++    +  G         +++   WDH+
Sbjct: 1535 QRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACD--GNEEAMKEQLEQLKEHWDHL 1592

Query: 608  RQLVPRRDQALTEEHARQQHNERLR 632
             +    + + L E   +Q+ N  +R
Sbjct: 1593 LERTNDKGKKLNEASRQQRFNTSIR 1617



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 83/460 (18%), Positives = 173/460 (37%), Gaps = 56/460 (12%)

Query: 271 ENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQE 330
           E+   ++ +++ A DL +WI   +  L ++  E+  + +Q K +  +         +VQ 
Sbjct: 50  EDSYHLQVFKRDADDLGKWIMEKVNILTDKSYEDPTN-IQGKYQKHQSLEA-----EVQT 103

Query: 331 KCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLE 390
           K +L       + +       A   ++   + ++ + W  L ++     + LL  ++  +
Sbjct: 104 KSRLMSELEKTREERFTMGHSAHEETKAH-IEELRHLWDLLLELTLEKGDQLLRALKFQQ 162

Query: 391 RLDHLAEKFRQKASIHEAWTDGKEAMLRQ----KDYETATLSEIKALLKKHEAFESDLAA 446
            +   A+           W   KEA+       +D+E       + L KK E F+ +L A
Sbjct: 163 YVQECADILE--------WIGDKEAIATSVELGEDWERT-----EVLHKKFEDFQVELVA 209

Query: 447 HQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLET 506
            + RV ++   A E  E ++ D P + ++  ++   W+ L  L  +R++AL     L   
Sbjct: 210 KEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKALSNAANL--- 266

Query: 507 IDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAH---EQFKATLPDADK 563
                  + +       W++     L        +   +GL  +H   E+  A + D  K
Sbjct: 267 -----QRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVK 321

Query: 564 ERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHA 623
           E  A      +  K+  ++        P      +++   W+H+R L   R + L   + 
Sbjct: 322 ELCA------KAEKLTLSH----PSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATY- 370

Query: 624 RQQHNERLRKQFGAQANVIGPWIQTKMEEIG--RISIEMHGTLEDQLSHLRQYEKSIVNY 681
                     +F +  + +  W+  K   I    +  ++ G  E  L   +Q++  I +Y
Sbjct: 371 -------WYHRFSSDFDELSGWMNEKTAAINADELPTDVAGG-EVLLDRHQQHKHEIDSY 422

Query: 682 KPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLL 721
             +    +   Q +  A    +      ME +   W  LL
Sbjct: 423 DDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALL 462



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 38/190 (20%), Positives = 82/190 (43%), Gaps = 11/190 (5%)

Query: 371  LEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIH--EAWTDGKEAMLRQKDYETATLS 428
            LEQ+++ ++  L     + ++L+  + + R   SI   E W    E +L  KD +   L+
Sbjct: 1582 LEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKD-QARDLA 1640

Query: 429  EIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGA 488
                LLKKH+  E ++ A +D ++ +  +A++L     ++   +  +   +  ++ N+  
Sbjct: 1641 SAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNVQE 1700

Query: 489  LTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLT 548
            L     E L+    L +    L  E         +W+E  +  +        ++ +Q L 
Sbjct: 1701 LAAAHHEKLKEAYALFQFFQDLDDE--------ESWIEEKLIRVSSQDYGRDLQGVQNLL 1752

Query: 549  TAHEQFKATL 558
              H++ +  L
Sbjct: 1753 KKHKRLEGEL 1762



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 78/455 (17%), Positives = 178/455 (39%), Gaps = 48/455 (10%)

Query: 272 NEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRR--LHKPPKVQ 329
           N   ++ +++  ++ ++WI+   P L +      + A +      +   R       KV+
Sbjct: 262 NAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVK 321

Query: 330 EKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRL 389
           E C           KL LS+ P+  P    M  D+ ++W  +  +     E L       
Sbjct: 322 ELC-------AKAEKLTLSH-PSDAPQIQEMKEDLVSSWEHIRALATSRYEKL------- 366

Query: 390 ERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQD 449
            +  +   +F         W + K A +   +  T      + LL +H+  + ++ ++ D
Sbjct: 367 -QATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGG-EVLLDRHQQHKHEIDSYDD 424

Query: 450 RVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQ 509
           R +      Q+L   ++  S  V  + + + + W  L  L  +R    E      + +D 
Sbjct: 425 RFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYE------QCLD- 477

Query: 510 LYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAIL 569
            +L Y + +   ++WM      L++  + +++   + L   HE F+      +++   I+
Sbjct: 478 FHLFY-RDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEK---II 533

Query: 570 GIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQH-- 627
            +    +K++        G + Y +   + I         L+ RRD AL E+ A ++   
Sbjct: 534 TVDKTATKLI--------GDDHYDSENIKAIRD------GLLARRD-ALREKAATRRRLL 578

Query: 628 -NERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKID 686
               L ++    ++ +  WI  K +       +    L+ ++   + +EK +   K +++
Sbjct: 579 KESLLLQKLYEDSDDLKNWINKKKKLADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQLE 638

Query: 687 QLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLL 721
            ++   Q + E   + + +    +  +   WE+LL
Sbjct: 639 NIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELL 673



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 63/293 (21%), Positives = 118/293 (40%), Gaps = 30/293 (10%)

Query: 218  IPKMLDAED-IVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVN---QENE 273
            +P++ D +D ++       KAI    ++    +   Q  E +A    K+L      Q+ E
Sbjct: 1985 LPEITDLKDKLISAQHNQSKAIEERYAALLKRWE--QLLEASAVHRQKLLEKQLPLQKAE 2042

Query: 274  QLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQ 333
             L  ++   AS L  W  +    L   V   +++ ++Q  +D  D+       +   KC 
Sbjct: 2043 DLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCL 2102

Query: 334  LEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLD 393
            LE     L  +++    P+  P     V  +   W  L  + +  E+ L  E  R  +  
Sbjct: 2103 LE-----LDQQIKALGVPS-SPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNF 2156

Query: 394  HLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQ 453
             + ++F Q AS    W             ET       +LLK+    ES L A++ + ++
Sbjct: 2157 EMCQEFEQNASTFLQWI-----------LETRAYFLDGSLLKETGTLESQLEANKRKQKE 2205

Query: 454  IAAIAQELNEL-----DYYDSPSVNARCQKI--CDQWDNLGALTQKRREALER 499
            I A+ ++L ++     +  D+  ++ +   I    QWD L  L  + +  LE+
Sbjct: 2206 IQAMKRQLTKIVDLGDNLEDALILDIKYSTIGLAQQWDQLYQLGLRMQHNLEQ 2258



 Score = 33.5 bits (75), Expect = 0.90
 Identities = 52/240 (21%), Positives = 91/240 (37%), Gaps = 35/240 (14%)

Query: 231 ARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDL-LEW 289
           AR D+  I+T +++++         +  A +   V       E L    +KL   L L+ 
Sbjct: 738 ARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQL 797

Query: 290 IRRTIP----WLENRVPENTMHAMQQKLEDFRDYRRLHK---------PPKVQEKCQLEI 336
           I R       W++   P  T   + + L   +     H+          P++QE      
Sbjct: 798 ICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQE------ 851

Query: 337 NFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLA 396
                     ++ R   M  EG   ++  +    ++ + +  E       RR   L+   
Sbjct: 852 ----------ITERGNKMVEEGHFAAE--DVASRVKSLNQNMESLRARAARRQNDLEANV 899

Query: 397 EKFRQKASIHEA--WTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQI 454
           +  +  A +HEA  W   KE ++   +Y  A      ALLKKHEAF  DL +  D ++ +
Sbjct: 900 QFQQYLADLHEAETWIREKEPIVDNTNYG-ADEEAAGALLKKHEAFLLDLNSFGDSMKAL 958


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.133    0.393 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,249,541
Number of Sequences: 37866
Number of extensions: 1372970
Number of successful extensions: 5118
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 131
Number of HSP's successfully gapped in prelim test: 161
Number of HSP's that attempted gapping in prelim test: 4068
Number of HSP's gapped (non-prelim): 871
length of query: 892
length of database: 18,247,518
effective HSP length: 111
effective length of query: 781
effective length of database: 14,044,392
effective search space: 10968670152
effective search space used: 10968670152
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

CSHL Press