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Search of human proteins with 44680105
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
(793 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 1535 0.0
gi|15149467 caldesmon 1 isoform 3 [Homo sapiens] 742 0.0
gi|15149463 caldesmon 1 isoform 4 [Homo sapiens] 738 0.0
gi|4826657 caldesmon 1 isoform 2 [Homo sapiens] 697 0.0
gi|15149465 caldesmon 1 isoform 5 [Homo sapiens] 692 0.0
gi|148746195 trichohyalin [Homo sapiens] 189 7e-48
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 183 6e-46
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 174 4e-43
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 167 4e-41
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 147 3e-35
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 146 8e-35
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 144 3e-34
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 144 3e-34
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 144 3e-34
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 144 3e-34
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 144 3e-34
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 144 3e-34
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 144 3e-34
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 144 3e-34
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 142 9e-34
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 141 3e-33
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 137 3e-32
gi|221219020 NYD-SP11 protein [Homo sapiens] 133 7e-31
gi|148839339 nexilin (F actin binding protein) [Homo sapiens] 132 1e-30
gi|55741709 RNA binding motif protein 25 [Homo sapiens] 131 2e-30
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 129 1e-29
gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens] 126 7e-29
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 124 3e-28
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 118 2e-26
gi|239745299 PREDICTED: hypothetical protein [Homo sapiens] 117 3e-26
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 1535 bits (3973), Expect = 0.0
Identities = 793/793 (100%), Positives = 793/793 (100%)
Query: 1 MDDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLG 60
MDDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLG
Sbjct: 1 MDDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLG 60
Query: 61 QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE 120
QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE
Sbjct: 61 QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE 120
Query: 121 FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA 180
FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA
Sbjct: 121 FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA 180
Query: 181 EENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQ 240
EENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQ
Sbjct: 181 EENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQ 240
Query: 241 EEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEK 300
EEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEK
Sbjct: 241 EEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEK 300
Query: 301 AAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIK 360
AAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIK
Sbjct: 301 AAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIK 360
Query: 361 EEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNE 420
EEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNE
Sbjct: 361 EEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNE 420
Query: 421 KKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKS 480
KKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKS
Sbjct: 421 KKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKS 480
Query: 481 FMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELR 540
FMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELR
Sbjct: 481 FMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELR 540
Query: 541 RRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEE 600
RRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEE
Sbjct: 541 RRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEE 600
Query: 601 KRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKS 660
KRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKS
Sbjct: 601 KRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKS 660
Query: 661 SGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEKGN 720
SGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEKGN
Sbjct: 661 SGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEKGN 720
Query: 721 VFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSKRNLWE 780
VFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSKRNLWE
Sbjct: 721 VFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSKRNLWE 780
Query: 781 KQSVDKVTSPTKV 793
KQSVDKVTSPTKV
Sbjct: 781 KQSVDKVTSPTKV 793
>gi|15149467 caldesmon 1 isoform 3 [Homo sapiens]
Length = 564
Score = 742 bits (1915), Expect = 0.0
Identities = 407/572 (71%), Positives = 440/572 (76%), Gaps = 37/572 (6%)
Query: 236 EEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEER------ERIKAEQDKKIA 289
EE + E ER E+ E + RA ER R + EE ++++ +
Sbjct: 16 EEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVP 75
Query: 290 DERAR-------IEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEER 342
DE A+ +E +++AA ER R E R+ KR E +R KE + +
Sbjct: 76 DEEAKTTTTNTQVEGDDEAAFLERLARREERRQ------KRLQEALERQKEFDPTITDAS 129
Query: 343 QRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRN-KQLEEKKHAMQE 401
+ + E+E+++ ++R EE E QK + + EE K +E
Sbjct: 130 LSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENK---KE 186
Query: 402 TKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKE 461
K K E+ E+K + + E QGEEKGTKVQAKREKLQEDKPTFKKE
Sbjct: 187 DKEKEEEEEEKPKRGSIGEN--------------QGEEKGTKVQAKREKLQEDKPTFKKE 232
Query: 462 EIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDT 521
EIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDT
Sbjct: 233 EIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDT 292
Query: 522 KEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEE 581
KEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEE
Sbjct: 293 KEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEE 352
Query: 582 EEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKG 641
EEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKG
Sbjct: 353 EEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKG 412
Query: 642 SSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASD 701
SSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASD
Sbjct: 413 SSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASD 472
Query: 702 LPVPAEGVRNIKSMWEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKSPA 761
LPVPAEGVRNIKSMWEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKSPA
Sbjct: 473 LPVPAEGVRNIKSMWEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKSPA 532
Query: 762 PKPSDLRPGDVSSKRNLWEKQSVDKVTSPTKV 793
PKPSDLRPGDVSSKRNLWEKQSVDKVTSPTKV
Sbjct: 533 PKPSDLRPGDVSSKRNLWEKQSVDKVTSPTKV 564
Score = 464 bits (1195), Expect = e-130
Identities = 293/555 (52%), Positives = 357/555 (64%), Gaps = 28/555 (5%)
Query: 1 MDDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLG 60
MDDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLG
Sbjct: 1 MDDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLG 60
Query: 61 QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE 120
QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE
Sbjct: 61 QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE 120
Query: 121 FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA 180
FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA
Sbjct: 121 FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA 180
Query: 181 EENKKEDKEKEEEEEEKPKRGSIGENQVE---VMVEEKTTESQEETVVMSLKNGQISSEE 237
EENKKEDKEKEEEEEEKPKRGSIGENQ E V+ K + QE+ + K +I E+
Sbjct: 181 EENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDK--PTFKKEEIKDEK 238
Query: 238 PKQEEE-REQGSDEISHHEKMEEEDKERAEAERARLEAEE----RERIKAEQDKKIADER 292
K+++E +E+ + + E + E +L+ E R +A D K A+
Sbjct: 239 IKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGA 298
Query: 293 ARIEAEEKAAAQERER--REAEERERMREEEKRAAEERQRIKE--EEKRAA--EERQRIK 346
++EA ++ R R E+EE E+++++++ AA E + +K+ EE+R EE QR K
Sbjct: 299 PQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRK 358
Query: 347 EEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKG 406
+EE A+ + R +EE++R EE +R RAE EK ++ L + K + KG
Sbjct: 359 QEE---ADRKLREEEEKRRLKEEIERRRAEAAEK---RQKMPEDGLSDDKKPFKCFTPKG 412
Query: 407 E--KVEQKIE--GKWVNEKKAQEDKLQTAVLKKQGE--EKGTKVQAKREKLQEDKPTFKK 460
K+E++ E K V + + Q A++ K E+ T + + KP
Sbjct: 413 SSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASD 472
Query: 461 EEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVD 520
+ E ++ K E+ F T K G + + E P G S
Sbjct: 473 LPVPAEGVRNIKSMWEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKSPA 532
Query: 521 TKEAEGAPQVEAGKR 535
K ++ P + KR
Sbjct: 533 PKPSDLRPGDVSSKR 547
Score = 33.5 bits (75), Expect = 0.79
Identities = 36/177 (20%), Positives = 77/177 (43%), Gaps = 39/177 (22%)
Query: 536 LEELRRRRGETESEEFEKLKQKQQEAALELEELKKKR-EERRKVLEEEEQRRKQEEADRK 594
+++ RRR E +QK++E LE E + +R ++ + E +RR ++E R+
Sbjct: 1 MDDFERRR--------ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQ 52
Query: 595 LREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLN 654
+EEE ++ +++E + +P++ T + ++ ++ A FL
Sbjct: 53 KQEEESLGQVTDQVE------VNAQNSVPDEEAKT--------TTTNTQVEGDDEAAFLE 98
Query: 655 KSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRN 711
+ ++ + R ++ A+E K PT AS L +P+ ++N
Sbjct: 99 RLARRE---------------ERRQKRLQEALERQKEFDPTITDAS-LSLPSRRMQN 139
Score = 30.8 bits (68), Expect = 5.1
Identities = 39/166 (23%), Positives = 67/166 (40%), Gaps = 27/166 (16%)
Query: 534 KRLEELRRRRGETESEEFEKL---KQKQQEAALELEELKKKREERRKVLEEEEQ-----R 585
+R ELRR++ E E E++ + E E ++ R+ER + +EEE
Sbjct: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTD 64
Query: 586 RKQEEADRKLREEEEK-RRLKEEIE--------RRRAEAAEKRQKMPEDGLSDDKKPFKC 636
+ + A + +EE K ++E R A E+RQK ++ L K+
Sbjct: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPT 124
Query: 637 FTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQY 682
T SL ++ +Q + T + K +SR E+Y
Sbjct: 125 ITDASLSLP--------SRRMQNDTAENETTEKE--EKSESRQERY 160
>gi|15149463 caldesmon 1 isoform 4 [Homo sapiens]
Length = 558
Score = 738 bits (1906), Expect = 0.0
Identities = 402/553 (72%), Positives = 434/553 (78%), Gaps = 37/553 (6%)
Query: 255 EKMEEEDKERAEAERARLEAEER------ERIKAEQDKKIADERAR-------IEAEEKA 301
E+ E + RA ER R + EE ++++ + DE A+ +E +++A
Sbjct: 29 EEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEA 88
Query: 302 AAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKE 361
A ER R E R+ KR E +R KE + + + + E
Sbjct: 89 AFLERLARREERRQ------KRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTE 142
Query: 362 EEKRAAEERQRARAEEEEKAKVEEQKRN-KQLEEKKHAMQETKIKGEKVEQKIEGKWVNE 420
+E+++ ++R EE E QK + + EE K +E K K E+ E+K + + E
Sbjct: 143 KEEKSESRQERYEIEETETVTKSYQKNDWRDAEENK---KEDKEKEEEEEEKPKRGSIGE 199
Query: 421 KKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKS 480
QGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKS
Sbjct: 200 N--------------QGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKS 245
Query: 481 FMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELR 540
FMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELR
Sbjct: 246 FMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELR 305
Query: 541 RRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEE 600
RRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEE
Sbjct: 306 RRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEE 365
Query: 601 KRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKS 660
KRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKS
Sbjct: 366 KRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKS 425
Query: 661 SGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEKGN 720
SGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEKGN
Sbjct: 426 SGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEKGN 485
Query: 721 VFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSKRNLWE 780
VFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSKRNLWE
Sbjct: 486 VFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSKRNLWE 545
Query: 781 KQSVDKVTSPTKV 793
KQSVDKVTSPTKV
Sbjct: 546 KQSVDKVTSPTKV 558
Score = 419 bits (1076), Expect = e-117
Identities = 269/532 (50%), Positives = 334/532 (62%), Gaps = 28/532 (5%)
Query: 24 RIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTT 83
+IAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTT
Sbjct: 18 QIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTT 77
Query: 84 TNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAE 143
TNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAE
Sbjct: 78 TNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAE 137
Query: 144 NETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSI 203
NETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSI
Sbjct: 138 NETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSI 197
Query: 204 GENQVE---VMVEEKTTESQEETVVMSLKNGQISSEEPKQEEE-REQGSDEISHHEKMEE 259
GENQ E V+ K + QE+ + K +I E+ K+++E +E+ + + E
Sbjct: 198 GENQGEEKGTKVQAKREKLQEDK--PTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTE 255
Query: 260 EDKERAEAERARLEAEE----RERIKAEQDKKIADERARIEAEEKAAAQERER--REAEE 313
+ E +L+ E R +A D K A+ ++EA ++ R R E+EE
Sbjct: 256 VKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEE 315
Query: 314 RERMREEEKRAAEERQRIKE--EEKRAA--EERQRIKEEEKRAAEERQRIKEEEKRAAEE 369
E+++++++ AA E + +K+ EE+R EE QR K+EE A+ + R +EE++R EE
Sbjct: 316 FEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEE---ADRKLREEEEKRRLKEE 372
Query: 370 RQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGE--KVEQKIE--GKWVNEKKAQE 425
+R RAE EK ++ L + K + KG K+E++ E K V + +
Sbjct: 373 IERRRAEAAEK---RQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVK 429
Query: 426 DKLQTAVLKKQGE--EKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMD 483
Q A++ K E+ T + + KP + E ++ K E+ F
Sbjct: 430 STHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEKGNVFSS 489
Query: 484 RKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKR 535
T K G + + E P G S K ++ P + KR
Sbjct: 490 PTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSKR 541
Score = 81.6 bits (200), Expect = 3e-15
Identities = 96/390 (24%), Positives = 176/390 (45%), Gaps = 63/390 (16%)
Query: 7 RRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQV 66
RRE RRQKR + LE ++ D R + E ++EE+S
Sbjct: 96 RREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKS-------- 147
Query: 67 EVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTIT 126
+ Q EE +T T + Q +A E +++ + +E E +K
Sbjct: 148 -ESRQERYEIEETETVTKSYQKNDWRDA--------EENKKEDKEKEEEEEEK------- 191
Query: 127 DASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKE 186
P R EN+ EK K ++++E+ + ++ +++K + +D E K+
Sbjct: 192 ------PKR---GSIGENQGEEKGTKVQAKREKLQEDK-----PTFKKEEIKD--EKIKK 235
Query: 187 DKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQ 246
DKE +EE + R G +V+ E T + T + G +S + K+ E
Sbjct: 236 DKEPKEEVKSFMDRKK-GFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAE---- 290
Query: 247 GSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQER 306
G+ ++ +++EE + R E E+EE E++K +Q + A +E EE +E
Sbjct: 291 GAPQVEAGKRLEELRRRRGET-----ESEEFEKLKQKQ------QEAALELEELKKKREE 339
Query: 307 ERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRA 366
R+ EE E+ R++E+ A+ + R +EE++R EE +R + E AAE+RQ++ E+
Sbjct: 340 RRKVLEEEEQRRKQEE--ADRKLREEEEKRRLKEEIERRRAE---AAEKRQKMPEDGLSD 394
Query: 367 AEERQRARAEEEEKAKVEEQKR--NKQLEE 394
++ + + K+EE+ NK +++
Sbjct: 395 DKKPFKCFTPKGSSLKIEERAEFLNKSVQK 424
Score = 55.5 bits (132), Expect = 2e-07
Identities = 74/366 (20%), Positives = 151/366 (41%), Gaps = 44/366 (12%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRND-DDEEEAARERRRRARQERLRQKQEEESLGQVT 63
E + E R+++ E E +YQ+ND D EE +E + + +E +K + S+G
Sbjct: 144 EEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEE--EEKPKRGSIG--- 198
Query: 64 DQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDP 123
+N ++ K +++ +D+ F ++EE + +++++ E ++E
Sbjct: 199 -------ENQGEEKGTKVQAKREKLQ-EDKPTF-----KKEEIKDEKIKKDKEPKEEV-K 244
Query: 124 TITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEEN 183
+ D + QN + E + SR +T+ + Q + EE
Sbjct: 245 SFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEEL 304
Query: 184 KKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEE 243
++ E E EE EK K+ + + + +EE + +E V+ EEE
Sbjct: 305 RRRRGETESEEFEKLKQ---KQQEAALELEELKKKREERRKVL--------------EEE 347
Query: 244 REQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAA 303
++ E + + EEE+K R + E R AE E+ + + ++D++ K
Sbjct: 348 EQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPF----KCFT 403
Query: 304 QERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEE 363
+ + EER E ++ ++ +K + A + + E+ +A E + +
Sbjct: 404 PKGSSLKIEER---AEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPT 460
Query: 364 KRAAEE 369
K AA +
Sbjct: 461 KPAASD 466
Score = 33.5 bits (75), Expect = 0.79
Identities = 36/177 (20%), Positives = 77/177 (43%), Gaps = 39/177 (22%)
Query: 1 MDDFERRR--------ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQ 52
+++ RRR E +QK++E LE E + +R ++ + E +RR ++E R+
Sbjct: 301 LEELRRRRGETESEEFEKLKQKQQEAALELEELKKKR-EERRKVLEEEEQRRKQEEADRK 359
Query: 53 KQEEESLGQVTDQVE------VNAQNSVPDEEAKT--------TTTNTQVEGDDEAAFLE 98
+EEE ++ +++E + +P++ T + ++ ++ A FL
Sbjct: 360 LREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLN 419
Query: 99 RLARRE---------------ERRQKRLQEALERQKEFDPTITDAS-LSLPSRRMQN 139
+ ++ + R ++ A+E K PT AS L +P+ ++N
Sbjct: 420 KSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRN 476
>gi|4826657 caldesmon 1 isoform 2 [Homo sapiens]
Length = 538
Score = 697 bits (1799), Expect = 0.0
Identities = 379/543 (69%), Positives = 426/543 (78%), Gaps = 29/543 (5%)
Query: 269 RARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEER 328
R L ++RE ++ E ++ IA +R + +E+ AA+ER RR +ER R ++EE+ +
Sbjct: 7 RRELRRQKREEMRLEAER-IAYQRN--DDDEEEAARERRRRARQERLRQKQEEESLGQVT 63
Query: 329 QRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKR 388
+++ + + + +EE + +++ +++ A ER R E +K E +R
Sbjct: 64 DQVEVNAQNS------VPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALER 117
Query: 389 NKQLE---------------EKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVL 433
K+ + + A ET K EK E + E + E + Q
Sbjct: 118 QKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDW 177
Query: 434 KKQGEEKGTKVQAKREKLQEDKP---TFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTE 490
+ E K K ++E+ +E+KP + + +IKDEKIKKDKEPKEEVKSFMDRKKGFTE
Sbjct: 178 RDAEENK--KEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTE 235
Query: 491 VKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEE 550
VKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEE
Sbjct: 236 VKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEE 295
Query: 551 FEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIER 610
FEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIER
Sbjct: 296 FEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIER 355
Query: 611 RRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAA 670
RRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAA
Sbjct: 356 RRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAA 415
Query: 671 IVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGT 730
IVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGT
Sbjct: 416 IVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGT 475
Query: 731 PNKETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSKRNLWEKQSVDKVTSP 790
PNKETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSKRNLWEKQSVDKVTSP
Sbjct: 476 PNKETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSKRNLWEKQSVDKVTSP 535
Query: 791 TKV 793
TKV
Sbjct: 536 TKV 538
Score = 459 bits (1182), Expect = e-129
Identities = 286/541 (52%), Positives = 343/541 (63%), Gaps = 26/541 (4%)
Query: 1 MDDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLG 60
MDDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLG
Sbjct: 1 MDDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLG 60
Query: 61 QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE 120
QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE
Sbjct: 61 QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE 120
Query: 121 FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA 180
FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA
Sbjct: 121 FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA 180
Query: 181 EENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQ 240
EENKKEDKEKEEEEEEKPKRGSIGENQ++ +K E +EE V S + + E K
Sbjct: 181 EENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEE--VKSFMDRKKGFTEVKS 238
Query: 241 EEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEK 300
+ + E H+ E+ RA ++ +E E + K +E R E +
Sbjct: 239 Q------NGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETE 292
Query: 301 AAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIK 360
+ E+ +++ +E EE K+ EER+++ EEE+ QR K+EE A+ + R +
Sbjct: 293 SEEFEKLKQKQQEAALELEELKKKREERRKVLEEEE------QRRKQEE---ADRKLREE 343
Query: 361 EEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGE--KVEQKIE--GK 416
EE++R EE +R RAE EK ++ L + K + KG K+E++ E K
Sbjct: 344 EEKRRLKEEIERRRAEAAEK---RQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNK 400
Query: 417 WVNEKKAQEDKLQTAVLKKQGE--EKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEP 474
V + + Q A++ K E+ T + + KP + E ++ K
Sbjct: 401 SVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSM 460
Query: 475 KEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGK 534
E+ F T K G + + E P G S K ++ P + K
Sbjct: 461 WEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSK 520
Query: 535 R 535
R
Sbjct: 521 R 521
Score = 37.4 bits (85), Expect = 0.055
Identities = 33/147 (22%), Positives = 66/147 (44%), Gaps = 8/147 (5%)
Query: 565 LEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPE 624
+++ +++RE RR+ + EE R + E + +++E+ +E RRRA RQK E
Sbjct: 1 MDDFERRRELRRQ--KREEMRLEAERIAYQRNDDDEEEAARE--RRRRARQERLRQKQEE 56
Query: 625 DGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTS 684
+ L + + +E A+ + Q ++ + + + R ++
Sbjct: 57 ESLGQVTDQVEV---NAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQE 113
Query: 685 AIEGTKSAKPTKPAASDLPVPAEGVRN 711
A+E K PT AS L +P+ ++N
Sbjct: 114 ALERQKEFDPTITDAS-LSLPSRRMQN 139
>gi|15149465 caldesmon 1 isoform 5 [Homo sapiens]
Length = 532
Score = 692 bits (1786), Expect = 0.0
Identities = 372/518 (71%), Positives = 412/518 (79%), Gaps = 26/518 (5%)
Query: 294 RIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAA 353
R + +E+ AA+ER RR +ER R ++EE+ + +++ + + + +EE +
Sbjct: 23 RNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNS------VPDEEAKTT 76
Query: 354 EERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLE---------------EKKHA 398
+++ +++ A ER R E +K E +R K+ + + A
Sbjct: 77 TTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTA 136
Query: 399 MQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKP-- 456
ET K EK E + E + E + Q + E K K ++E+ +E+KP
Sbjct: 137 ENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENK--KEDKEKEEEEEEKPKR 194
Query: 457 -TFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGG 515
+ + +IKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGG
Sbjct: 195 GSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGG 254
Query: 516 RASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREER 575
RASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREER
Sbjct: 255 RASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREER 314
Query: 576 RKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFK 635
RKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFK
Sbjct: 315 RKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFK 374
Query: 636 CFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPT 695
CFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPT
Sbjct: 375 CFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPT 434
Query: 696 KPAASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPD 755
KPAASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPD
Sbjct: 435 KPAASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPD 494
Query: 756 GNKSPAPKPSDLRPGDVSSKRNLWEKQSVDKVTSPTKV 793
GNKSPAPKPSDLRPGDVSSKRNLWEKQSVDKVTSPTKV
Sbjct: 495 GNKSPAPKPSDLRPGDVSSKRNLWEKQSVDKVTSPTKV 532
Score = 414 bits (1063), Expect = e-115
Identities = 262/518 (50%), Positives = 320/518 (61%), Gaps = 26/518 (5%)
Query: 24 RIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTT 83
+IAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTT
Sbjct: 18 QIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTT 77
Query: 84 TNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAE 143
TNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAE
Sbjct: 78 TNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAE 137
Query: 144 NETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSI 203
NETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSI
Sbjct: 138 NETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSI 197
Query: 204 GENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKE 263
GENQ++ +K E +EE V S + + E K + + E H+ E+
Sbjct: 198 GENQIKDEKIKKDKEPKEE--VKSFMDRKKGFTEVKSQ------NGEFMTHKLKHTENTF 249
Query: 264 RAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKR 323
RA ++ +E E + K +E R E ++ E+ +++ +E EE K+
Sbjct: 250 SRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKK 309
Query: 324 AAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKV 383
EER+++ EEE+ QR K+EE A+ + R +EE++R EE +R RAE EK
Sbjct: 310 KREERRKVLEEEE------QRRKQEE---ADRKLREEEEKRRLKEEIERRRAEAAEK--- 357
Query: 384 EEQKRNKQLEEKKHAMQETKIKGE--KVEQKIE--GKWVNEKKAQEDKLQTAVLKKQGE- 438
++ L + K + KG K+E++ E K V + + Q A++ K
Sbjct: 358 RQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSR 417
Query: 439 -EKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGE 497
E+ T + + KP + E ++ K E+ F T K G
Sbjct: 418 LEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGTPNKETAGL 477
Query: 498 FMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKR 535
+ + E P G S K ++ P + KR
Sbjct: 478 KVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSKR 515
Score = 53.5 bits (127), Expect = 7e-07
Identities = 81/359 (22%), Positives = 151/359 (42%), Gaps = 70/359 (19%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRND-DDEEEAARERRRRARQERLRQKQEEESLGQVT 63
E + E R+++ E E +YQ+ND D EE +E + + +E +K + S+G+
Sbjct: 144 EEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEE--EEKPKRGSIGENQ 201
Query: 64 DQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDP 123
+ E ++ P EE K+ D + F E ++ E +L+
Sbjct: 202 IKDEKIKKDKEPKEEVKSFM-------DRKKGFTEVKSQNGEFMTHKLKH---------- 244
Query: 124 TITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEEN 183
T+ + S P R DT E E + E + R E ET ++ ++K
Sbjct: 245 --TENTFSRPGGRASVDTKEAEGAPQVEAGK-RLEELRRRRGETESEEFEK-------LK 294
Query: 184 KKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEE 243
+K+ + E EE K KR E + +V+ EE+ QEE + + ++EEE
Sbjct: 295 QKQQEAALELEELKKKR----EERRKVLEEEEQRRKQEE-----------ADRKLREEEE 339
Query: 244 REQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAE---QDKK----IADERARIE 296
+ + +EI ++ RAEA AE+R+++ + DKK + + ++
Sbjct: 340 KRRLKEEI---------ERRRAEA------AEKRQKMPEDGLSDDKKPFKCFTPKGSSLK 384
Query: 297 AEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEE 355
EE+A E + ++ ++ + A + + E+ +A E + + K AA +
Sbjct: 385 IEERA---EFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASD 440
Score = 33.5 bits (75), Expect = 0.79
Identities = 36/177 (20%), Positives = 77/177 (43%), Gaps = 39/177 (22%)
Query: 1 MDDFERRR--------ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQ 52
+++ RRR E +QK++E LE E + +R ++ + E +RR ++E R+
Sbjct: 275 LEELRRRRGETESEEFEKLKQKQQEAALELEELKKKR-EERRKVLEEEEQRRKQEEADRK 333
Query: 53 KQEEESLGQVTDQVE------VNAQNSVPDEEAKT--------TTTNTQVEGDDEAAFLE 98
+EEE ++ +++E + +P++ T + ++ ++ A FL
Sbjct: 334 LREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLN 393
Query: 99 RLARRE---------------ERRQKRLQEALERQKEFDPTITDAS-LSLPSRRMQN 139
+ ++ + R ++ A+E K PT AS L +P+ ++N
Sbjct: 394 KSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRN 450
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 189 bits (481), Expect = 7e-48
Identities = 175/720 (24%), Positives = 343/720 (47%), Gaps = 112/720 (15%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQ-----EEESLG 60
RR+EL RQ REE L+ E R + ++ RER+ R +E RQK+ +E+
Sbjct: 1162 RRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRS 1221
Query: 61 QVTDQVEVNAQNSVPD----------------EEAKTTTTNTQVE-----GDDEAAFLER 99
+ Q E +N+V D E+++ +Q + G+ + E+
Sbjct: 1222 DLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQ 1281
Query: 100 LARREERRQKRL--QEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQ 157
RR ++R + +E LER+++ + D S +++ + E + +E + R+
Sbjct: 1282 ERRRWQQRDRHFPEEEQLEREEQKEAKRRDRK-SQEEKQLLREEREEKRRRQETDRKFRE 1340
Query: 158 ERYEIEETETVTKSYQKND--WRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEK 215
E ++E E Q+ D +R+ E +E K EEE++ +R E + + + EE+
Sbjct: 1341 EEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRR---QERERKFLKEEQ 1397
Query: 216 TTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAE 275
QE + Q+ + ++ E EQ K EE+++ ER R E
Sbjct: 1398 QLRCQE-------REQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLE 1450
Query: 276 ERERIKAEQDKKIADE------------------RARIEAEEKAAAQERERREAEERERM 317
E ++++ E+ +K +E R +E E++ QER+R+ E+ R
Sbjct: 1451 EEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRS 1510
Query: 318 REEEKRAAEERQRI--KEEEKRAAEERQRIKEEEK---RAAEERQRIKEEE--KRAAEER 370
+E E++ EE Q++ ++ +++ +E Q+++ +E+ R + ++ +EEE ++ EE+
Sbjct: 1511 QEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQ 1570
Query: 371 QRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQT 430
Q +R E + K ++EEQK +Q +E+K E +++ ++ +Q++ + ++K +ED+
Sbjct: 1571 QLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQE--RDRKFREDE--- 1625
Query: 431 AVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTE 490
L ++ EE+ Q + K E++P +++E ++++++ D+ DRK E
Sbjct: 1626 -QLLQEREEQQLHRQERDRKFLEEEPQLRRQE-REQQLRHDR----------DRKFREEE 1673
Query: 491 VKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEE 550
Q GE +L+ E D K E Q+ +R + + + +E
Sbjct: 1674 QLLQEGE--EQQLRRQER-----------DRKFREEEQQLRRQERERKFLQEEQQLRRQE 1720
Query: 551 FEKLKQKQQEAALELEELKKKREER-RKVLEE-------EEQRRKQEEADRKLREEEEKR 602
E+ +++++ E E+ + +R+ER RK+LEE EEQ+ +++E DRK REEE+ R
Sbjct: 1721 LERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLR 1780
Query: 603 RLKEEIERRRAEAAEK-------RQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNK 655
+ +EE + R E+ K RQ+ E L ++ K + + L++EE+ + L +
Sbjct: 1781 QEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGK-YRWEEEQLQLEEQEQRLRQ 1839
Score = 187 bits (475), Expect = 3e-47
Identities = 164/648 (25%), Positives = 327/648 (50%), Gaps = 71/648 (10%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTD 64
+R+REL+ ++ + +LE + + +R ++++++ +R R+++LR+KQEEE Q +
Sbjct: 266 QRQRELQEEEEQLRKLERQELRRERQEEEQQQ-----QRLRREQQLRRKQEEERREQQEE 320
Query: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPT 124
+ E + +E + Q E ++ R + EERR+++L+ E ++
Sbjct: 321 RREQQERREQQEERREQQLRREQEERREQQL---RREQEEERREQQLRREQEEERREQQL 377
Query: 125 ITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENK 184
+ L RR Q E + +++ +Q R E + ++ R+ EE +
Sbjct: 378 RREQQL----RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEER 433
Query: 185 KEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEER 244
E K ++E E++ KR E + + + E+ TE E+ E KQ+ +R
Sbjct: 434 HEQKHEQERREQRLKREQ--EERRDWLKREEETERHEQ-------------ERRKQQLKR 478
Query: 245 EQGSDEISHHEKMEEEDK-ERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAA 303
+Q + K+EEE++ E+ E +L E+ ER EQ K +E R++ ++ +
Sbjct: 479 DQEEERRERWLKLEEEERREQQERREQQLRREQEER--REQRLKRQEEEERLQ--QRLRS 534
Query: 304 QERERREAEERERM---REEEKRAAEER--QRIKEEE--------KRAAEER-QRIKEEE 349
+++ RRE EER REEEKR +ER QR+K E+ KR E R QR+K E+
Sbjct: 535 EQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQ 594
Query: 350 KRAAEERQRIKEEEKRAAEERQRARAEEEE----------KAKVEEQKRNKQLEEKKHAM 399
+ E+R + +E E+ EER+ R + EE K++ +E++R +QL ++
Sbjct: 595 EERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQER 654
Query: 400 QETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQ---EDKP 456
+E ++K E+ E+++E + +++ +E++ + + +++ E+ +++++ K Q E +
Sbjct: 655 REQRLKREEEEERLEQRL--KREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEA 712
Query: 457 TFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGR 516
++ ++ K++ + + + + R++ +E++ Q E H+ + E +
Sbjct: 713 DARQSKVYSRPRKQEGQRRRQEQE-EKRRRRESELQWQEEE-RAHRQQQEEEQRRDFTWQ 770
Query: 517 ASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERR 576
+ K G ++ A L E R R + +EE ++ +Q+ E E+ +++R ER
Sbjct: 771 WQAEEKSERGRQRLSARPPLREQRER--QLRAEERQQREQRFLPEEEEKEQRRRQRRERE 828
Query: 577 K---VLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQK 621
K LEEEEQ +++E A ++L+EEE+ L+E+ ERRR++ + QK
Sbjct: 829 KELQFLEEEEQLQRRERA-QQLQEEED--GLQEDQERRRSQEQRRDQK 873
Score = 182 bits (463), Expect = 8e-46
Identities = 176/688 (25%), Positives = 328/688 (47%), Gaps = 89/688 (12%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRNDD---DEEEAARERR-RRARQERLRQKQEEESLG 60
E EL+R++RE+ R + + Y+ + +EE+ RE R +R RQER RQ ++++ L
Sbjct: 908 EEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQ 967
Query: 61 QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE 120
Q +Q+ E+ + + ++E E REER ++R QE + ++
Sbjct: 968 QKEEQLL-----GEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRK 1022
Query: 121 FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEI-EETET-----VTKSYQK 174
D + L R + E E +EE+ ++E + EE ET + + Y+K
Sbjct: 1023 KDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRK 1082
Query: 175 NDWRDAEENK--KEDKEK----------EEEEEEKPKRGSIGENQVEVMVEEKTTESQEE 222
+ EE + +E+ EK EEEE + + + + E ++ E
Sbjct: 1083 EEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYRE 1142
Query: 223 TVVMSLKNGQISSEEP----KQEEEREQGSDEISHHEK----MEEEDKERAEAERARLEA 274
+ + Q+ EEP +QE ER+ +E E+ EE++K R E ER E
Sbjct: 1143 EEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREE 1202
Query: 275 EERERIKAEQDKKIADERARI----EAEEKAAAQE-------------RERREAEERERM 317
EE +R K +Q + D+R+ + E E++ A ++ R+ +++ R+R
Sbjct: 1203 EELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQ 1262
Query: 318 REEEKR--AAEERQRIKEEEKRAAEERQR-IKEEEKRAAEERQRIKEEEKRAAEERQRAR 374
+++ + E+++R +E+E+R ++R R EEE+ EE++ K ++++ EE+Q R
Sbjct: 1263 SQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLR 1322
Query: 375 AEEEEKAKVEEQKRNKQLEEK----------KHAMQETKIKGEKVEQKIEGKWVNEKKAQ 424
E EEK + +E R + EE+ + ++ K + E++ + +G+ E++ Q
Sbjct: 1323 EEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEE-Q 1381
Query: 425 EDKLQTAVLKKQGEEKGTKVQAKREKLQEDKP-TFKKEE---IKDEKIKKDKEPKEEVKS 480
+ Q K EE+ + Q + ++L++D+ F++EE + E+ +K +E +++V+
Sbjct: 1382 RLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRR 1441
Query: 481 FMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEE-- 538
+R++ F E + Q + K + E + +E + Q K LEE
Sbjct: 1442 -QERERKFLEEEQQLRQERHRKFREEEQLLQ--------EREEQQLHRQERDRKFLEEEQ 1492
Query: 539 -LRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQE-------E 590
LRR+ + + E E Q+ + LE E+ +++ +RK L+EE+Q R+QE +
Sbjct: 1493 QLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQD 1552
Query: 591 ADRKLREEEEKRRLKEEIERRRAEAAEK 618
DRK REEE+ R+ +EE + R E K
Sbjct: 1553 RDRKFREEEQLRQEREEQQLSRQERDRK 1580
Score = 181 bits (458), Expect = 3e-45
Identities = 180/713 (25%), Positives = 335/713 (46%), Gaps = 113/713 (15%)
Query: 7 RRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQV 66
R+ Q+REE R E E++ + + EE E+ RR LR+K EE Q ++
Sbjct: 175 RQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQ 234
Query: 67 EVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTIT 126
+ Q E K T + E E+L E +RQ+ LQE E+ ++ +
Sbjct: 235 DRVFQEEEEKEWRKRETVLRKEE--------EKLQEEEPQRQRELQEEEEQLRKLERQEL 286
Query: 127 DASLSLPSRRMQNDTAENETTEK--EEKSESRQERYEIEETETVTKSYQKNDWRDAEENK 184
++ Q E + K EE+ E ++ER E +E + ++ R +E +
Sbjct: 287 RRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEER 346
Query: 185 KEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEER 244
+E + + E+EEE+ E Q+ EE+ E Q + Q+ E+ + E++
Sbjct: 347 REQQLRREQEEERR------EQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQ 400
Query: 245 EQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIA-------DERARIEA 297
+ ++ +++ E + R E + R + EER K EQ+++ + R ++
Sbjct: 401 LRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKR 460
Query: 298 EEKAAAQERERR--------EAEERER---MREEEKRAAEER--QRIKEEEKRAAEERQR 344
EE+ E+ERR E E RER + EEE+R +ER Q+++ E++ E+R +
Sbjct: 461 EEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLK 520
Query: 345 IKEEEKRAA--------------EERQRI--KEEEKRAAEER--QRARAEEEEKA----K 382
+EEE+R E R+++ +EEEKR +ER QR + E+EE+ K
Sbjct: 521 RQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLK 580
Query: 383 VEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQ----EDKLQTAVLKKQGE 438
EE++R ++L+ ++ E ++K E+VE ++E + E++ + E++ + +LK + +
Sbjct: 581 REEERRQQRLKREQEERLEQRLKREEVE-RLEQEERREQRLKREEPEEERRQQLLKSEEQ 639
Query: 439 EKGTKVQAKREKLQEDKPTFKKEEIKDE-----KIKKDKEPKEEVKSFMDRKKGFTEVKS 493
E+ + Q +RE+ + + K+EE ++ K + ++E +E+ + ++++ +KS
Sbjct: 640 EERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKS 699
Query: 494 QNGEFMTHKLKHTE----NTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESE 549
+ ++ + +SRP ++ EG Q ++ E+ RRR E + +
Sbjct: 700 RIPKWQWQLESEADARQSKVYSRP--------RKQEG--QRRRQEQEEKRRRRESELQWQ 749
Query: 550 EFEKLKQKQQEA-----------ALELEELKKKREERRKVLEEEEQRR-----KQEEADR 593
E E+ ++QQE A E E ++R R L E+ +R+ +Q+ R
Sbjct: 750 EEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQR 809
Query: 594 KLREEEEK--------------RRLKEEIERRRAEAAEKRQKMPEDGLSDDKK 632
L EEEEK + L+EE + +R E A++ Q+ EDGL +D++
Sbjct: 810 FLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQE-EEDGLQEDQE 861
Score = 181 bits (458), Expect = 3e-45
Identities = 174/689 (25%), Positives = 339/689 (49%), Gaps = 102/689 (14%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQ 65
RR+E RQ REE L+ E +E+ ER +R RQE RQ +EEE + Q +Q
Sbjct: 1102 RRQERERQCREEEELQQE---------EEQLLREEREKRRRQELERQYREEEEVQQEEEQ 1152
Query: 66 VEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFL--ERLARREER-RQKRLQEALERQK--- 119
+ +E + + +E L E+ RR+ER RQ R +E L+RQK
Sbjct: 1153 LLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQ 1212
Query: 120 -------------EFDPTITDASLSLPSRRMQNDTAENETTEKEEKSE--SRQERYEIE- 163
+++P +A + ++ ENE + E S+ RQ + +++
Sbjct: 1213 RYRDEDQRSDLKWQWEPEKENA---VRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQH 1269
Query: 164 ---ETETVTKSYQKNDW--RDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTE 218
E + + ++ W RD ++E E+EE++E K +R + + +++ EE+ +
Sbjct: 1270 LLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAK-RRDRKSQEEKQLLREEREEK 1328
Query: 219 SQEETVVMSLKNG----QISSEEP--KQEEEREQGSDEISHHEK----MEEEDK-ERAEA 267
+ + + Q E+P +QE +R+ +E+ H E+ +EEE + R E
Sbjct: 1329 RRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQER 1388
Query: 268 ERARLEAEERERIKAEQDKKIADERAR--IEAEEKAAAQERER--REAEERERMREEEKR 323
ER L+ E++ R + E+++++ +R R E E++ + QER+R RE E++ R +E E++
Sbjct: 1389 ERKFLKEEQQLRCQ-EREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERK 1447
Query: 324 AAEERQRIKEEEKRAAEERQRI-----------KEEEKRAAEERQRIKEEEKRAAEERQR 372
EE Q++++E R E +++ +E +++ EE Q+++ +E+ Q
Sbjct: 1448 FLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQE 1507
Query: 373 ARAEE-EEKAKVEEQKRNKQLEEKKHAMQETKI----KGEKVEQKIEGKWVNEKKAQEDK 427
R++E E K EEQ+ ++Q ++K +E ++ +G++ Q + K+ E++ ++++
Sbjct: 1508 LRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQER 1567
Query: 428 LQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKG 487
+ L +Q ++ +++ ++ + QE + F ++DE+ + +E +++++ DRK
Sbjct: 1568 -EEQQLSRQERDRKFRLEEQKVRRQEQERKF----MEDEQQLRRQEGQQQLRQERDRK-- 1620
Query: 488 FTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETE 547
F E + E +L E D K E PQ+ +R ++LR R
Sbjct: 1621 FREDEQLLQEREEQQLHRQER-----------DRKFLEEEPQLRRQEREQQLRHDRDRKF 1669
Query: 548 SE--------EFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEE 599
E E ++L++++++ EE + +R+ER + +EEQ+ +++E +RK REEE
Sbjct: 1670 REEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEE 1729
Query: 600 EKRRLKEEIERRRAE----AAEKRQKMPE 624
+ R+ E+ + RR E E+ Q PE
Sbjct: 1730 QLRQETEQEQLRRQERYRKILEEEQLRPE 1758
Score = 180 bits (457), Expect = 4e-45
Identities = 172/699 (24%), Positives = 330/699 (47%), Gaps = 89/699 (12%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQ--RNDDDEEEAARERRRRARQERLRQKQEEESLGQV 62
E RRE ++ EE RLE ER + R ++ + +R RQ+RL+++QEE L Q
Sbjct: 543 EERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEER-LEQR 601
Query: 63 TDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRL--------QEA 114
+ EV + EE + + ++ L + +EERRQ++L ++
Sbjct: 602 LKREEVER---LEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQR 658
Query: 115 LERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESR----QERYEIEETETVTK 170
L+R++E + R + + AE E + E+ +SR Q + E E +K
Sbjct: 659 LKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSK 718
Query: 171 SYQKNDWRDAEENKKEDKEKE-----------------EEEEEKPKRGSIGENQVEVMVE 213
Y + ++ + ++E +EK +++EE+ +R + Q E E
Sbjct: 719 VYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSE 778
Query: 214 EKTTESQEETVVMSLKNGQISSEEPKQ--------EEEREQGSDEISHHEK---MEEEDK 262
+ + Q+ +EE +Q EEE+EQ + EK EE++
Sbjct: 779 RGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEE 838
Query: 263 ERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERR------------- 309
+ ERA+ EE + ++ +Q+++ + E+ R + +ER+RR
Sbjct: 839 QLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQ 898
Query: 310 ----------EAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEE-EKRAAEERQR 358
E EE +R E++R E+ ++ +EEE+ EE Q ++EE EKR +ER+R
Sbjct: 899 LRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERER 958
Query: 359 IKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWV 418
++K+ ++ ++ EE EK + +E+++ K EE++ +E ++ E+ E++ +W
Sbjct: 959 QYRKDKKLQQKEEQLLGEEPEKRRRQEREK-KYREEEELQQEEEQLLREEREKRRRQEWE 1017
Query: 419 NEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEV 478
+ + ++D+LQ Q EE+ + + ++ +LQE + +++EE ++ ++ + E
Sbjct: 1018 RQYR-KKDELQ------QEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERET 1070
Query: 479 KSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEE 538
+ + ++ + + + E +L E R R +E E + E R E
Sbjct: 1071 RRRQELERQYRKEEELQQE--EEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREER 1128
Query: 539 LRRRRGETESE--EFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLR 596
+RRR E E + E E+++Q++++ E E ++++E R+ EEEE Q+E ++ LR
Sbjct: 1129 EKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEEL---QQEEEQLLR 1185
Query: 597 EEEEKRRLKEEIERRRAEAAEKRQK----MPEDGLSDDK 631
EE+EKRR + E + R E +++++ ED SD K
Sbjct: 1186 EEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLK 1224
Score = 180 bits (456), Expect = 5e-45
Identities = 173/687 (25%), Positives = 324/687 (47%), Gaps = 62/687 (9%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTD 64
E R + RRQ+RE + +++ + +E+ E +R RQER ++ +EEE L Q +
Sbjct: 946 EEREKRRRQERERQYRKDKKLQQK----EEQLLGEEPEKRRRQEREKKYREEEELQQEEE 1001
Query: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPT 124
Q+ + E+ + Q DE E REER ++RLQE + +E +
Sbjct: 1002 QLLREER-----EKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEEL 1056
Query: 125 ITDASLSLPSRRMQNDTAENETT-EKEEKSESRQERYEIEETETVTKSYQKNDWRDAEEN 183
+ L R E E KEE+ + +E+ EE E + ++ R+ EE
Sbjct: 1057 QQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEEL 1116
Query: 184 KKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEP----K 239
++E+++ EE EK +R + E Q EE+ + +EE Q+ EEP +
Sbjct: 1117 QQEEEQLLREEREKRRRQEL-ERQYR---EEEEVQQEEE---------QLLREEPEKRRR 1163
Query: 240 QEEEREQGSDEISHHEK----MEEEDKERAEAERARLEAEERERIKAEQDKKIADERARI 295
QE ER+ +E E+ EE++K R E ER E EE +R K +Q + D+R+ +
Sbjct: 1164 QELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDL 1223
Query: 296 E-----AEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEK 350
+ +E A + + E E+ R+ E +RQ ++ + E+++R +E+E+
Sbjct: 1224 KWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQER 1283
Query: 351 RAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVE 410
R ++R R EE++ E Q+ + K++ E+Q ++ EEK+ QET K + E
Sbjct: 1284 RRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRR-QETDRKFREEE 1342
Query: 411 QKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKL--QEDKPTFKKEEI----- 463
Q ++ + + QE + + + +E+G K + ++L QE + F KEE
Sbjct: 1343 QLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQ 1402
Query: 464 -KDEKIKKDKEPK----EEVKSFMDRKKGFTEVKSQ-NGEFMTHKLKHTENTFSRPGGRA 517
+++++++D++ K E+ S +R + F E + Q + K E + R
Sbjct: 1403 EREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRK 1462
Query: 518 SVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRK 577
+E E Q ++L R+ R EE ++L++++++ +EL+ + ER K
Sbjct: 1463 F---REEEQLLQEREEQQLH--RQERDRKFLEEEQQLRRQERDRKFREQELRSQEPER-K 1516
Query: 578 VLEEEEQRRKQE------EADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDK 631
LEEE+Q +Q+ + +++LR +E ++ +++ +R+ E + RQ+ E LS +
Sbjct: 1517 FLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQE 1576
Query: 632 KPFKCFTPKGSSLKIEERAEFLNKSVQ 658
+ K + + E+ +F+ Q
Sbjct: 1577 RDRKFRLEEQKVRRQEQERKFMEDEQQ 1603
Score = 179 bits (455), Expect = 7e-45
Identities = 170/675 (25%), Positives = 322/675 (47%), Gaps = 104/675 (15%)
Query: 2 DDFERRR--ELRRQKREEMRLEAERIAYQRN-------------------DDDEEEAARE 40
+D ERRR E RR ++ +LE ER + +++EE E
Sbjct: 858 EDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREE 917
Query: 41 RRRRARQERLRQKQEEESLGQVTDQV--EVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLE 98
R +R RQE+ RQ +EEE L Q +Q+ E + + E + + +++ E
Sbjct: 918 REKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEE 977
Query: 99 RLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQE 158
RR + R+K+ +E E Q+E ++ + E ++ E+ +++
Sbjct: 978 PEKRRRQEREKKYREEEELQQE-------------EEQLLREEREKRRRQEWERQYRKKD 1024
Query: 159 RYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTE 218
+ EE + + + +K ++ E +E++E ++EEE +++ EE+ T
Sbjct: 1025 ELQQEEEQLLREEREKRRLQERERQYREEEELQQEEE-------------QLLGEERETR 1071
Query: 219 SQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERE 278
++E Q EE Q+EE + +E EK +++ER E L+ EE +
Sbjct: 1072 RRQEL------ERQYRKEEELQQEEEQLLREE---PEKRRRQERERQCREEEELQQEEEQ 1122
Query: 279 RIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRA 338
++ E++K+ E R EE+ QE E+ EE E+ R +E ERQ +EEE +
Sbjct: 1123 LLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQEL----ERQYREEEELQQ 1178
Query: 339 AEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHA 398
EE+ +E+EKR E ++ +EEE+ ++R++ +E++++ ++ Q EK++A
Sbjct: 1179 EEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWE----PEKENA 1234
Query: 399 MQETKI--KGEKVEQ--KIEGKWVNEKKAQEDKLQTAVLKKQGE---------------- 438
+++ K+ KG + EQ ++E + ++++Q+D LQ + ++Q
Sbjct: 1235 VRDNKVYCKGRENEQFRQLEDSQLRDRQSQQD-LQHLLGEQQERDREQERRRWQQRDRHF 1293
Query: 439 ------EKGTKVQAKR--EKLQEDKPTFKKE-EIKDEKIKKDKEPKEEVKSFMDRKKGFT 489
E+ + +AKR K QE+K ++E E K + + D++ +EE + +R++
Sbjct: 1294 PEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPL 1353
Query: 490 EVKSQNGEFMTHKLKHTEN-----TFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRG 544
+ ++ +F +L+H E + R + K + Q+ +R ++LR+ R
Sbjct: 1354 RRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRD 1413
Query: 545 ETESEEFEKLKQKQQEAALELEELKKKREER-RKVLEEEEQRRKQEEADRKLREEEEKRR 603
EE ++L +++++ EE + +R+ER RK LEEE+Q R +E RK REEE+ +
Sbjct: 1414 RKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLR--QERHRKFREEEQLLQ 1471
Query: 604 LKEEIERRRAEAAEK 618
+EE + R E K
Sbjct: 1472 EREEQQLHRQERDRK 1486
Score = 179 bits (454), Expect = 9e-45
Identities = 174/707 (24%), Positives = 332/707 (46%), Gaps = 80/707 (11%)
Query: 4 FERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQER-------------- 49
+ R R+ Q+R + + E R EEE A +++ Q R
Sbjct: 720 YSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSER 779
Query: 50 ----------LRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFL-- 97
LR+++E + + Q E Q +P+EE K + E + E FL
Sbjct: 780 GRQRLSARPPLREQRERQLRAEERQQRE---QRFLPEEEEKEQRRRQRREREKELQFLEE 836
Query: 98 -ERLARREERRQKR-----LQEALERQKEFDPTITDA---SLSLPSRRMQN-----DTAE 143
E+L RRE +Q + LQE ER++ + L +R ++ +
Sbjct: 837 EEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQ 896
Query: 144 NETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSI 203
+ ++++ + +E + EE E + Q+ +R+ E+ ++E+++ EE EK +R
Sbjct: 897 EQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRR--- 953
Query: 204 GENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPK--QEEEREQGSDEI--SHHEKMEE 259
E + + ++K + +E+ + + + E K +EEE +Q +++ EK
Sbjct: 954 QERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRR 1013
Query: 260 EDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMRE 319
++ ER ++ L+ EE + ++ E++K+ ER R EE+ QE E+ EERE R
Sbjct: 1014 QEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRR 1073
Query: 320 EEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEE 379
+E ERQ KEEE + EE+ +E EKR +ER+R EE+ +E ++ EE E
Sbjct: 1074 QEL----ERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREERE 1129
Query: 380 KAKVEEQKRNKQLEEKKHAMQETKIKGE---KVEQKIEGKWVNEKKAQEDKLQTAVLKKQ 436
K + +E +R + EE+ +E ++ E + Q++E ++ E++ Q+++ Q +L+++
Sbjct: 1130 KRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQ--LLREE 1187
Query: 437 GEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDK----EPKEEVKSFMDRKKGFTEVK 492
E++ + + + + +E + +K+ +DE + D EP++E + D K K
Sbjct: 1188 QEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKE-NAVRDNK---VYCK 1243
Query: 493 SQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFE 552
+ E + + E++ R ++ D + G Q +R E RRR + F
Sbjct: 1244 GRENE----QFRQLEDSQLR-DRQSQQDLQHLLGEQQ----ERDREQERRRWQQRDRHFP 1294
Query: 553 KLKQKQQEAALELEELKKKREERRKVL-EEEEQRRKQEEADRKLREEEEKRRLKEEIERR 611
+ +Q ++E E + +K +E +++L EE E++R+++E DRK REEE+ + +EE R
Sbjct: 1295 EEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLR 1354
Query: 612 RAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQ 658
R E+ +K E+ L ++ K + + E +FL + Q
Sbjct: 1355 R---QERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQ 1398
Score = 171 bits (433), Expect = 2e-42
Identities = 155/665 (23%), Positives = 315/665 (47%), Gaps = 87/665 (13%)
Query: 102 RREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYE 161
RR+E Q+R E +RQ E +P RR + E E E EE+SE +QER E
Sbjct: 113 RRQEEDQRRF-EPRDRQLEEEPG--------QRRRQKRQEQERELAEGEEQSE-KQERLE 162
Query: 162 IEETETVTKSY--QKNDWRDAEENKKEDKE----KEEEEEEKP----------------- 198
+ + + Q+ +W++ EE + E+++ K E EE P
Sbjct: 163 QRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKG 222
Query: 199 ---KRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHE 255
K+ E Q V EE+ E ++ V+ EE QEEE ++ + E
Sbjct: 223 REEKQQQRRERQDRVFQEEEEKEWRKRETVLR------KEEEKLQEEEPQRQRELQEEEE 276
Query: 256 KMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEER- 314
++ + +++ ER E ++++R++ EQ + E R E +E+ Q+ R + EER
Sbjct: 277 QLRKLERQELRRERQE-EEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERR 335
Query: 315 -ERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRA 373
+++R E++ E++ R ++EE+R ++ +R +EEE+R E++ R +++ +R + R+
Sbjct: 336 EQQLRREQEERREQQLRREQEEERREQQLRREQEEERR--EQQLRREQQLRREQQLRREQ 393
Query: 374 RAEEEEKAKVEEQ-KRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQ----EDKL 428
+ E++ + E+Q +R +QL ++ +E +++ E+ E++ E K E++ Q E +
Sbjct: 394 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEE 453
Query: 429 QTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKE---EIKDEKIKKDKEPKEEVKSFMDRK 485
+ LK++ E + + + ++++L+ D+ ++E ++++E+ ++ +E +E+ +
Sbjct: 454 RRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEE 513
Query: 486 KGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGE 545
+ +K Q E + +E R + E ++E +R + L+R + E
Sbjct: 514 RREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEE 573
Query: 546 -------TESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRK---- 594
E E ++ +++QE LE + LK++ ER + E EQR K+EE + +
Sbjct: 574 RRDQLLKREEERRQQRLKREQEERLE-QRLKREEVERLEQEERREQRLKREEPEEERRQQ 632
Query: 595 -LREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFL 653
L+ EE++ R ++++ R + E E+R K E+ ++E+R +
Sbjct: 633 LLKSEEQEERRQQQLRREQQERREQRLKREEE-----------------EERLEQRLKRE 675
Query: 654 NKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIK 713
++ ++ + Q +I SR+ ++ +E A+ +K P EG R +
Sbjct: 676 HEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSK--VYSRPRKQEGQRRRQ 733
Query: 714 SMWEK 718
EK
Sbjct: 734 EQEEK 738
Score = 170 bits (431), Expect = 4e-42
Identities = 151/648 (23%), Positives = 317/648 (48%), Gaps = 63/648 (9%)
Query: 1 MDDFERRR-ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESL 59
+D+ +R R + + ++ R E ++ ++ D EE +RRR+ RQE+ R+ E E
Sbjct: 95 LDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQ 154
Query: 60 GQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQK 119
+ +++E + DEE Q ER RR E Q + + E ++
Sbjct: 155 SEKQERLEQRDRQR-RDEELWRQRQEWQ----------EREERRAEEEQLQSCKGHETEE 203
Query: 120 EFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRD 179
D L RR + + + E++++ +E E + ETV + K + +
Sbjct: 204 FPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLR---KEEEKL 260
Query: 180 AEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETV--VMSLKNGQISSEE 237
EE + +E +EEEE+ K + E+ E + E Q++ + L+ Q
Sbjct: 261 QEEEPQRQRELQEEEEQLRKL-----ERQELRRERQEEEQQQQRLRREQQLRRKQEEERR 315
Query: 238 PKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEA 297
+QEE REQ E+ E++++ R + R E ++++ EQ+++ +++ R E
Sbjct: 316 EQQEERREQ-------QERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQ 368
Query: 298 EEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQ 357
EE+ Q+ R + RE+ E++ E+Q +E++ R Q+++ E++ E++
Sbjct: 369 EEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR---REQQLRREQQLRREQQL 425
Query: 358 RIKEEEKRAAEERQRARAEEEEKAKVEEQ----KRNKQLEEKKHAMQETKIKGEKVEQKI 413
R ++EE+R ++ ++ R E+ K + EE+ KR ++ E + ++ ++K ++ E++
Sbjct: 426 RREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERR 485
Query: 414 EGKWV----NEKKAQEDKLQTAVLKKQGE--EKGTKVQAKREKLQ-----EDKPTFKKEE 462
E +W+ E++ Q+++ + + ++Q E E+ K Q + E+LQ E + ++EE
Sbjct: 486 E-RWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEE 544
Query: 463 IKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTK 522
+++ +K+++E + E + R K E + + + + + + + R
Sbjct: 545 RREQLLKREEEKRLEQERREQRLK--REQEERRDQLLKREEERRQQRLKREQEERLEQRL 602
Query: 523 EAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEE 582
+ E ++E +R E+ R +R E E E ++L + +++ ++L+++++ERR
Sbjct: 603 KREEVERLEQEERREQ-RLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERR------ 655
Query: 583 EQRRKQEEADRKL-----REEEEKRRLKEEIERRRAEAAEK-RQKMPE 624
EQR K+EE + +L RE EE+RR +E E + +A E+ + ++P+
Sbjct: 656 EQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPK 703
Score = 169 bits (428), Expect = 9e-42
Identities = 160/678 (23%), Positives = 322/678 (47%), Gaps = 84/678 (12%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTD 64
ERR + R+++EE R E + Q + E++ RE++ R R+++LR++Q+ Q+
Sbjct: 345 ERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLR-REQQLRREQQLRREQQLRR 403
Query: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPT 124
+ ++ + + E+ + E ++E +ERR++RL+ E ++++
Sbjct: 404 EQQLRREQQLRREQQLRREQQLRREQEEER---HEQKHEQERREQRLKREQEERRDWLKR 460
Query: 125 ITDASLSLPSRRMQNDTAENETTEKEEKSESRQERY-EIEETETVTKSYQKNDW-RDAEE 182
+ RR Q K ++ E R+ER+ ++EE E + ++ R +E
Sbjct: 461 EEETERHEQERRKQQ--------LKRDQEEERRERWLKLEEEERREQQERREQQLRREQE 512
Query: 183 NKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTE----SQEETVVMSLKNGQISSEEP 238
++E + K +EEEE+ ++ E Q+ EE+ + +E+ + + ++ E+
Sbjct: 513 ERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQE 572
Query: 239 -------KQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADE 291
K+EEER Q + E++E+ K R E ER E +R+K E+ ++ +
Sbjct: 573 ERRDQLLKREEERRQQRLKREQEERLEQRLK-REEVERLEQEERREQRLKREEPEEERRQ 631
Query: 292 RARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQR---IKEE 348
+ E++ Q++ RRE +ER RE+ + EE +R+++ KR EE +R + EE
Sbjct: 632 QLLKSEEQEERRQQQLRREQQER---REQRLKREEEEERLEQRLKREHEEERREQELAEE 688
Query: 349 EKRAAEER------------------QRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNK 390
E+ A ER ++ K + +E QR R E+EEK + E +
Sbjct: 689 EQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQW 748
Query: 391 QLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREK 450
Q EE+ H Q+ E+ + +W E+K++ + + + E++ +++A+ E+
Sbjct: 749 QEEERAHRQQQE----EEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAE-ER 803
Query: 451 LQEDKPTFKKEEIKDEKIKKDKEPK------EEVKSFMDRKKGFTEVKSQNGEFMTHKLK 504
Q ++ +EE K+++ ++ +E + EE + R++ + ++G + +
Sbjct: 804 QQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERR 863
Query: 505 HTENTFSRPGGRASVD--------TKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQ 556
++ R ++ T A+ A Q + K + L+ E + EE EK ++
Sbjct: 864 RSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRR 923
Query: 557 KQQEAALELEE---------LKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEE 607
++QE EE L+++RE+RR+ ++R +Q D+KL+++EE + L EE
Sbjct: 924 QEQERQYREEEQLQQEEEQLLREEREKRRR-----QERERQYRKDKKLQQKEE-QLLGEE 977
Query: 608 IERRRAEAAEKRQKMPED 625
E+RR + EK+ + E+
Sbjct: 978 PEKRRRQEREKKYREEEE 995
Score = 165 bits (418), Expect = 1e-40
Identities = 150/622 (24%), Positives = 308/622 (49%), Gaps = 62/622 (9%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTD 64
ER + RRQ+ + E E++ +R +++ +ER R+ R+E LR +++ +
Sbjct: 1324 EREEKRRRQETDRKFREEEQLLQER--EEQPLRRQERDRKFREEELRHQEQGRKFLEEEQ 1381
Query: 65 QV---EVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLE---RLARREERRQKRLQEALERQ 118
++ E + +++ + Q+ D + F E +L+R+E R+ R +E R+
Sbjct: 1382 RLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRR 1441
Query: 119 KEFDPTITDASLSLPSRRMQNDTAENETT-EKEEKSESRQERYE--IEETETVTKSYQKN 175
+E + + L R + E + E+EE+ RQER +EE + + + +
Sbjct: 1442 QERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDR 1501
Query: 176 DWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISS 235
+R+ E +E + K EEE++ R + Q + + EE+ QE +
Sbjct: 1502 KFREQELRSQEPERKFLEEEQQLHRQ---QRQRKFLQEEQQLRRQERGQQRRQDRDRKFR 1558
Query: 236 EEPKQEEEREQGSDEISHHEK-----MEEEDKERAEAERARLEAEERERIKAEQDKKIAD 290
EE + +ERE+ ++S E+ +EE+ R E ER +E E++ R + E +++
Sbjct: 1559 EEEQLRQEREE--QQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLR-RQEGQQQLRQ 1615
Query: 291 ERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEK 350
ER R E++ QERE ++ +ER +++ EE +++ +E+ E+Q + ++
Sbjct: 1616 ERDRKFREDEQLLQEREEQQLHRQER----DRKFLEEEPQLRRQER----EQQLRHDRDR 1667
Query: 351 RAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVE 410
+ EE Q ++E EE+Q R E + K + EEQ+ +Q E+K +E +++ +++E
Sbjct: 1668 KFREEEQLLQE-----GEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELE 1722
Query: 411 QKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKK 470
+K +E++L+ ++ +E+ + + R+ L+E++ ++EE + + ++
Sbjct: 1723 RKFR---------EEEQLR----QETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQER 1769
Query: 471 DKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQV 530
D++ +EE + +R++ +++SQ + K + E + + +E + PQ
Sbjct: 1770 DRKFREEEQLRQEREE--QQLRSQESD---RKFREEE--------QLRQEREEQQLRPQQ 1816
Query: 531 EAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEE 590
GK E + + E + + + + +Q A + +K R E +++ +EEEQ+R+QE
Sbjct: 1817 RDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQER 1876
Query: 591 ADRKLREEEEKRRLKEEIERRR 612
+RKLREE +R+ KEE R+
Sbjct: 1877 -ERKLREEHIRRQQKEEQRHRQ 1897
Score = 152 bits (384), Expect = 1e-36
Identities = 153/605 (25%), Positives = 284/605 (46%), Gaps = 88/605 (14%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTD 64
E + LRRQ+RE L+ ++++ +ER ++ RQ+R R+ +EEE Q++
Sbjct: 1378 EEEQRLRRQERERKFLK----------EEQQLRCQEREQQLRQDRDRKFREEEQ--QLSR 1425
Query: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPT 124
Q E D + E+ RR+ER +K L+E + ++E
Sbjct: 1426 Q-----------------------ERDRKFREEEQQVRRQERERKFLEEEQQLRQE---- 1458
Query: 125 ITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYE--IEETETVTKSYQKNDWRDAEE 182
R + E E+EE+ RQER +EE + + + + +R+ E
Sbjct: 1459 ----------RHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQEL 1508
Query: 183 NKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEE 242
+E + K EEE++ R + Q + + EE+ QE + EE + +
Sbjct: 1509 RSQEPERKFLEEEQQLHR---QQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQ 1565
Query: 243 EREQGSDEISHHE-----KMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEA 297
ERE+ ++S E ++EE+ R E ER +E E++ R + E +++ ER R
Sbjct: 1566 EREE--QQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLR-RQEGQQQLRQERDRKFR 1622
Query: 298 EEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQ 357
E++ QERE ++ +ER +++ EE +++ +E+ E+Q + +++ EE Q
Sbjct: 1623 EDEQLLQEREEQQLHRQER----DRKFLEEEPQLRRQER----EQQLRHDRDRKFREEEQ 1674
Query: 358 RIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKI-EGK 416
++E EE+Q R E + K + EEQ+ +Q E+K +E +++ +++E+K E +
Sbjct: 1675 LLQE-----GEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEE 1729
Query: 417 WVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKE 476
+ ++ QE + +K EE+ + + + ++L+ + K E +E++++++E ++
Sbjct: 1730 QLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFRE--EEQLRQEREEQQ 1787
Query: 477 EVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRL 536
DRK F E + E +L RP R E E E +RL
Sbjct: 1788 LRSQESDRK--FREEEQLRQEREEQQL--------RPQQRDGKYRWEEEQLQLEEQEQRL 1837
Query: 537 EELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLR 596
+ R R+ E + + K +++E L EE +K+R+ER + L EE RR+Q+E R +
Sbjct: 1838 RQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQ 1897
Query: 597 EEEEK 601
E K
Sbjct: 1898 VGEIK 1902
Score = 122 bits (307), Expect = 1e-27
Identities = 111/429 (25%), Positives = 219/429 (51%), Gaps = 32/429 (7%)
Query: 6 RRRELRRQKREEMRLEAERIAY----QRNDDDEEEAAR--ERRRRARQERLRQKQEEESL 59
R +ELR Q+ E LE E+ + QR EE+ R ER ++ RQ+R R+ +EEE L
Sbjct: 1504 REQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQL 1563
Query: 60 GQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQK 119
Q ++ +++ Q + + K +V ++ ER +E++ +R + + ++
Sbjct: 1564 RQEREEQQLSRQ----ERDRKFRLEEQKVRRQEQ----ERKFMEDEQQLRRQEGQQQLRQ 1615
Query: 120 EFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRD 179
E D + L R Q + E++ K + + +E E + + +R+
Sbjct: 1616 ERDRKFREDEQLLQEREEQ----QLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFRE 1671
Query: 180 AEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEE-KTTESQEETVVMSLKNGQISSEEP 238
E+ +E +E++ +E+ ++ E Q+ E K + +++ L+ E+
Sbjct: 1672 EEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQL 1731
Query: 239 KQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAE 298
+QE E+EQ + + K+ EE++ R E E +L +ER+R K +++++ ER E
Sbjct: 1732 RQETEQEQLRRQ-ERYRKILEEEQLRPEREEQQLRRQERDR-KFREEEQLRQER----EE 1785
Query: 299 EKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQR 358
++ +QE +R+ EE + +E E++ +QR + + R EE+ +++E+E+R +ER R
Sbjct: 1786 QQLRSQESDRKFREEEQLRQEREEQQLRPQQR--DGKYRWEEEQLQLEEQEQRLRQERDR 1843
Query: 359 IKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWV 418
E++ A + +++R EE+E + EEQKR ++ E K ++E I+ ++ E++ + V
Sbjct: 1844 QYRAEEQFATQ-EKSRREEQELWQEEEQKRRQERERK---LREEHIRRQQKEEQ-RHRQV 1898
Query: 419 NEKKAQEDK 427
E K+QE K
Sbjct: 1899 GEIKSQEGK 1907
Score = 94.7 bits (234), Expect = 3e-19
Identities = 76/346 (21%), Positives = 176/346 (50%), Gaps = 46/346 (13%)
Query: 300 KAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEE-----RQRIKEEEKRAAE 354
+A + E+R + + +++R E+++R + +++ EE RQ+ +E+E+ AE
Sbjct: 91 QATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAE 150
Query: 355 ERQRIKEEEKRAAEERQRARAE-----------EEEKAKVEEQKRNKQLEEKKHAMQETK 403
++ +++E+ +RQR E EE +A+ E+ + K E ++ +E
Sbjct: 151 GEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQL 210
Query: 404 IKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGE----EKGTKVQAKREKLQEDKPTFK 459
+ E +E + +G+ EK+ Q + Q V +++ E ++ T ++ + EKLQE++P +
Sbjct: 211 RRRELLELRRKGR--EEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQ-R 267
Query: 460 KEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASV 519
+ E+++E+ + K ++E++ + Q E +L+ + +
Sbjct: 268 QRELQEEEEQLRKLERQELRR-----------ERQEEEQQQQRLRREQQLRRK------- 309
Query: 520 DTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVL 579
+E E Q E + +E R ++ E ++ + +++++E L E+ +++RE++ +
Sbjct: 310 --QEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRRE 367
Query: 580 EEEEQRRKQEEADRKLREEEEKRR---LKEEIERRRAEAAEKRQKM 622
+EEE+R +Q +++LR E++ RR L+ E + RR + + Q++
Sbjct: 368 QEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 413
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 183 bits (464), Expect = 6e-46
Identities = 158/635 (24%), Positives = 319/635 (50%), Gaps = 60/635 (9%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRND--DDEEEAARERRRRARQERLRQKQEEESLGQV 62
E+ +++R+Q+ E+M + ER+ Q + EE+ R+ +R QE+ ++QE+E +
Sbjct: 283 EQEKKIRKQE-EKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKE----L 337
Query: 63 TDQVEVNAQ-NSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEF 121
+Q E+ Q + ++E K ++ +E + + E+ +Q R QE R +E
Sbjct: 338 REQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEE 397
Query: 122 DPTITDASLSLPSRRMQNDTAENETTEK--------EEKSESRQERYEIEETETVTKSYQ 173
D L RM+ E EK E++ ++R + +++E E + + +
Sbjct: 398 RMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREK 457
Query: 174 KNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQI 233
K R+ EE +E +EK +++EE E Q + + E+K E E M + +I
Sbjct: 458 K--MREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQK--EKLWEQEKMQEQEEKI 513
Query: 234 SSEEPKQEEEREQGSDE--ISHHEKM--------EEEDKERAEAERARLEAEERERIKAE 283
+E K ++ E E + EKM E+E+K R + ++ + E E+ E
Sbjct: 514 WEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQE 573
Query: 284 QDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQ 343
Q+KK D+ ++ EE+ +ERE++ EE E MRE+E++ E+ ++++E+E++ E+ +
Sbjct: 574 QEKKTWDQEEKMREEER--MREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEE 631
Query: 344 RIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEE--EKAKVEEQKRNKQLEEKKHAMQE 401
+++E+E++ E+ +++ E+E++ E+++ +E+ E K++EQ++ ++ EEK ++
Sbjct: 632 KMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEK 691
Query: 402 TKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKE 461
+ K ++ E+K W EK +E+ ++ K + EE+ + Q ++ + QE+K ++E
Sbjct: 692 MEKKTQEQEKK---TWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEE 748
Query: 462 EI--KDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASV 519
E+ ++EK+ + +E E + ++K+ E K++ E +
Sbjct: 749 EMWEQEEKMWEQEEKMWEQQRLPEQKEKLWE---------HEKMQEQEKIWE-------- 791
Query: 520 DTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVL 579
+E + Q E + EE + RG+ E ++ K QE + +E K +E +
Sbjct: 792 --QEEKMRDQEEKMRGQEE--KMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWG 847
Query: 580 EEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAE 614
+EE+ K + + K+RE+EEK R +EE R + E
Sbjct: 848 QEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEE 882
Score = 172 bits (437), Expect = 8e-43
Identities = 150/630 (23%), Positives = 309/630 (49%), Gaps = 44/630 (6%)
Query: 38 ARERRRRARQERLRQKQEEESLGQVTDQVEVNA----QNSVPDEEAKTTTTNTQVEGDDE 93
A E +R R K+ + + ++T + + + +N++ +EE K Q ++
Sbjct: 178 AGELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQ----EK 233
Query: 94 AAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKS 153
E + K L+ LER K P + +L R + + E E ++++
Sbjct: 234 LPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEE 293
Query: 154 ESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVE 213
+ ++ + E E + ++ WR + ++++KE E+E+E ++ + E + ++ +
Sbjct: 294 KMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQ 353
Query: 214 EKTTESQEETVVMSLKNGQISSEEPKQEEER--EQGSDEISHHEKMEEEDKERAEAERAR 271
E+ QEE + + E+ ++EER EQ +KM ++++ E +
Sbjct: 354 EEKMWEQEEKM-------REQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERL 406
Query: 272 LEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEER----ERMREEEKRAAEE 327
E EER R + +K+ ++ ++ E+K QE++ R+ EE+ ER+RE EK+ EE
Sbjct: 407 REKEERMR----EQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREE 462
Query: 328 RQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQK 387
+ ++E+E++ ++ + + E+E++ ++++ +++EK +E+ + E+EEK +E+K
Sbjct: 463 EETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQ---EQEEKIWEQEEK 519
Query: 388 RNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAK 447
Q E+ ++ + EK+ ++ + W E+K + D+ Q +++ EK T+ Q K
Sbjct: 520 IRDQ--EEMWGQEKKMWRQEKMREQEDQMWEQEEKMR-DQEQKMWDQEERMEKKTQEQEK 576
Query: 448 REKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTE 507
+ QE+K ++EE E+ KK +E +EE+ + K E K Q E K+ E
Sbjct: 577 KTWDQEEK--MREEERMREREKKMRE-EEEMMREQEEKMQEQEEKMQEQE---EKMWEQE 630
Query: 508 NTFSRPGGRA-SVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELE 566
+ + K E ++ +RL E + + E E + ++ Q+Q+E E E
Sbjct: 631 EKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQE 690
Query: 567 ELKKKREERRKVLEEEEQRRKQE---EADRKLREEEEKRRLKEEIERRRAEAAEKRQKMP 623
+++KK +E+ K ++E+ R++E E ++K+REEEE R +EE + E EK Q+
Sbjct: 691 KMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEE---KMQEQEEKMQEQE 747
Query: 624 EDGLSDDKKPFKCFTPKGSSLKIEERAEFL 653
E+ ++K ++ ++ E+ E L
Sbjct: 748 EEMWEQEEKMWEQEEKMWEQQRLPEQKEKL 777
Score = 172 bits (436), Expect = 1e-42
Identities = 149/634 (23%), Positives = 317/634 (50%), Gaps = 38/634 (5%)
Query: 7 RRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQV 66
+ E+ RQ+ EE+R + ++I Q EE + R R++ + +++EE + + ++
Sbjct: 271 QEEMWRQE-EELREQEKKIRKQ------EEKMWRQEERLREQEGKMREQEEKMWRQEKRL 323
Query: 67 EVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTIT 126
+ + ++E + E +++ E +E + + +E + RQ+E +
Sbjct: 324 R-EQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEE---RLW 379
Query: 127 DASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEET--ETVTKSYQKNDWRDAEENK 184
+ + + + E E++E+ ++ER +E E V K ++ ++ E+
Sbjct: 380 EQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKT 439
Query: 185 KEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEER 244
++ +EK +EEE I E + ++ EE+T QEE + +N E+ Q++
Sbjct: 440 RDQEEKMQEEER------IREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRL 493
Query: 245 EQGSDEISHHEKMEEEDKERAEAERARLEAEE---RERIKAEQDKKIADERARIEAEEKA 301
+ +++ EKM+E++++ E E + EE +E+ Q+K E E EEK
Sbjct: 494 PEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKM 553
Query: 302 AAQERERREAEER--ERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRI 359
QE++ + EER ++ +E+EK+ ++ ++++EEE R E ++++EEE+ E+ +++
Sbjct: 554 RDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEE-RMREREKKMREEEEMMREQEEKM 612
Query: 360 KEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVN 419
+E+E++ E+ ++ E+EEK + +E+K +Q EEK +E + +++ ++ E W +
Sbjct: 613 QEQEEKMQEQEEK-MWEQEEKMQEQEEKMWEQ-EEKMWEQEEKMWEQQRLPEQKEKLWEH 670
Query: 420 EKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVK 479
EK +++K+Q K +EK K ++EK D+ ++EE E+ KK +E +E ++
Sbjct: 671 EKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMR 730
Query: 480 SFMDRKKGFTE-VKSQNGEFMTHKLKHTENTFSRPGGRASVDTKE-----AEGAPQVEAG 533
++ + E ++ Q E + K E + + KE + Q +
Sbjct: 731 EQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIW 790
Query: 534 KRLEELR----RRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQE 589
++ E++R + RG+ E ++ K + QE + +E K +E + +EE+ ++E
Sbjct: 791 EQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEE 850
Query: 590 EADRKLREEEEKRRLKEEIERRRAE-AAEKRQKM 622
+ + K++ +EEK R +EE R + E E+ +KM
Sbjct: 851 KMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKM 884
Score = 166 bits (420), Expect = 8e-41
Identities = 163/626 (26%), Positives = 301/626 (48%), Gaps = 79/626 (12%)
Query: 16 EEMRLEAERIAY-----QRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNA 70
+E++ + ER + Q N EE +E R +++++R KQEE+ Q
Sbjct: 249 KELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIR-KQEEKMWRQ--------- 298
Query: 71 QNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASL 130
+ + ++E K E +++ E+ R +E+ + ++ L QKE + +
Sbjct: 299 EERLREQEGKMR------EQEEKMWRQEKRLREQEKELREQEKELREQKE----LREQEE 348
Query: 131 SLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEK 190
+ + + E + E+EEK ++ER +E + Q+ RD EE E E+
Sbjct: 349 QMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQM---REQEQKMRDQEERMWEQDER 405
Query: 191 EEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEER--EQGS 248
E+EE+ + QVE M EEK + QE+ EE QEEER E+
Sbjct: 406 LREKEERMREQEKMWEQVEKMREEKKMQEQEKKTR--------DQEEKMQEEERIREREK 457
Query: 249 DEISHHEKMEEEDKERAEAERARLEAEERE---RIKAEQDKKIADERARIEAEEKAAAQE 305
E M E++++ + E E EE+E + EQ +K+ ++ E EEK QE
Sbjct: 458 KMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQE 517
Query: 306 RERREAEE----------RERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEE 355
+ R+ EE +E+MRE+E + E+ ++++++E++ ++ +R+ E+K +E
Sbjct: 518 EKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERM--EKKTQEQE 575
Query: 356 RQRIKEEEKRAAEERQRARAEEEEKAKVEEQ---KRNKQLEEKKHAMQETKIK----GEK 408
++ +EEK EER R E E+K + EE+ ++ ++++E++ MQE + K EK
Sbjct: 576 KKTWDQEEKMREEERMR---EREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEK 632
Query: 409 VEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKI 468
++++ E W E+K E + + ++ E+K + + EK+QE + ++EE E+
Sbjct: 633 MQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQK--EKLWEHEKMQEQEKMQEQEEKIWEQE 690
Query: 469 KKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAP 528
K +K+ +E+ K D++K E + E K++ E R + + +
Sbjct: 691 KMEKKTQEQEKKTWDQEKMREEESMRERE---KKMREEEEMM-----REQEEKMQEQEEK 742
Query: 529 QVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQ 588
E + + E + E E + +E+ + +Q+ L E K +E+ K+ E+EE+ R Q
Sbjct: 743 MQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHE---KMQEQEKIWEQEEKMRDQ 799
Query: 589 EEADRKLREEEEKRRLKEEIERRRAE 614
EE K+R +EEK R +EE R + E
Sbjct: 800 EE---KMRGQEEKMRGQEEKMRGQEE 822
Score = 159 bits (401), Expect = 1e-38
Identities = 153/646 (23%), Positives = 311/646 (48%), Gaps = 77/646 (11%)
Query: 16 EEMRLEAERIAYQ--RNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNS 73
EE+ E + ++ + RN EE +++ QE+L + E+S ++++N +
Sbjct: 200 EELTKERDALSLELYRNTITNEEL--KKKNAELQEKLPLAESEKS------EIQLNVKEL 251
Query: 74 VPD-EEAK----TTTTNTQVEG----DDEAAFLERLARREERRQKRLQEALERQKEFDPT 124
E AK TNT E ++E E+ R++E + R +E L Q+
Sbjct: 252 KRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEG---- 307
Query: 125 ITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENK 184
R + E +E++ E R++ E+ E + + + Q+ ++ EE
Sbjct: 308 --------KMREQEEKMWRQEKRLREQEKELREQEKELREQKELRE--QEEQMQEQEEKM 357
Query: 185 KEDKEKEEEEEEKPKRGS--IGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEE 242
E +EK E+EEK R + E + ++ +E+ QEE + + + E +++E
Sbjct: 358 WEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQE 417
Query: 243 EREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAA 302
+ + +++ +KM+E++K+ + E + +E ERI+ + K +E E EEK
Sbjct: 418 KMWEQVEKMREEKKMQEQEKKTRDQEE---KMQEEERIREREKKMREEEETMREQEEKMQ 474
Query: 303 AQERERREAEERE-----------------RMREEEKRAAEERQRIKEEEKRAAEERQRI 345
QE E EE+E +M+E+E++ E+ ++I+++E+ +E++
Sbjct: 475 KQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMW 534
Query: 346 KEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIK 405
++E+ R E++ +EE+ R E++ + E EK E++K+ EEK + + +
Sbjct: 535 RQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMRER 594
Query: 406 GEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKL--QEDKPTFKKEEI 463
+K+ ++ E E+K QE + + +++ E+ K+Q + EK+ QE+K ++E++
Sbjct: 595 EKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKM 654
Query: 464 -KDEKIKKDKEPKEEVKSFMDRKK-GFTEVKSQNGEFMTHKLKHTE-NTFSRPGGRASVD 520
+ +++ + KE E + +++K E K E M K + E T+ + R
Sbjct: 655 WEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEES 714
Query: 521 TKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKRE------- 573
+E E + E EE+ R + E E+ EK++++++E + E++ ++ E
Sbjct: 715 MREREKKMREE-----EEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQR 769
Query: 574 --ERRKVLEEEEQRRKQE---EADRKLREEEEKRRLKEEIERRRAE 614
E+++ L E E+ ++QE E + K+R++EEK R +EE R + E
Sbjct: 770 LPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEE 815
Score = 152 bits (384), Expect = 1e-36
Identities = 119/486 (24%), Positives = 253/486 (52%), Gaps = 44/486 (9%)
Query: 1 MDDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLG 60
M + E++ + +K +E ER R +++ E+ ++ + Q+++E
Sbjct: 432 MQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQ 491
Query: 61 QVTDQVE-VNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREER---RQKRLQEALE 116
++ +Q E + Q + ++E K ++ +E E+ R+E+ ++ ++ E E
Sbjct: 492 RLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEE 551
Query: 117 RQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKND 176
+ ++ + + D Q + E +T E+E+K+ ++E+ EE ++
Sbjct: 552 KMRDQEQKMWD----------QEERMEKKTQEQEKKTWDQEEKMREEE----RMREREKK 597
Query: 177 WRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSE 236
R+ EE +E +EK +E+EEK + Q E M E++ ++E + + E
Sbjct: 598 MREEEEMMREQEEKMQEQEEKM------QEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQE 651
Query: 237 EPKQEEER-EQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARI 295
E E++R + +++ HEKM+E++K + + E+ E E+ E+ EQ+KK D+
Sbjct: 652 EKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKI-WEQEKMEKKTQEQEKKTWDQE--- 707
Query: 296 EAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEE 355
+ E+ + +ERE++ EE E MRE+E++ E+ ++++E+E+ E+ +++ E+E++ E+
Sbjct: 708 KMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQ 767
Query: 356 RQRIKEEEKRAAEERQRARA---EEEEKAKVEEQKRNKQLE-----EKKHAMQETKIKG- 406
++ +++EK E+ + + E+EEK + +E+K Q E E+K QE K+ G
Sbjct: 768 QRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQ 827
Query: 407 -EKVEQKIEGKWVNEKK--AQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEI 463
EK+ + E W E+K QE+K++ K QG+E+ + Q ++ + QE+K ++E++
Sbjct: 828 EEKMWGQEEKMWGQEEKMWGQEEKMEE---KMQGQEEKMREQEEKMRGQEEKMREQEEKM 884
Query: 464 KDEKIK 469
+ ++ K
Sbjct: 885 RGQEEK 890
Score = 143 bits (361), Expect = 5e-34
Identities = 149/629 (23%), Positives = 292/629 (46%), Gaps = 90/629 (14%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTD 64
E+ +ELR Q++E +R + E + ++EE E+ + R++ + ++EE L +
Sbjct: 325 EQEKELREQEKE-LREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEK 383
Query: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREE--RRQKRLQEALERQKEFD 122
Q+ Q EE E ++ E++ + E R +K++QE ++ ++ +
Sbjct: 384 QMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQE 443
Query: 123 PTITDASLSLPSRRMQNDTAENETTEKEEKSESRQER-YEIEETETVTKSYQKND---WR 178
+ + + R + E E+EEK + ++E +E EE E + + W
Sbjct: 444 EKMQEEE-RIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWE 502
Query: 179 DAEENKKEDKEKEEEEEEKPKRGSIGENQV----EVMVEEKTTESQEETVVMSLKNGQIS 234
+ ++E+K E+EE+ + + G+ + E M E++ ++E + +
Sbjct: 503 QEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWD 562
Query: 235 SEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAE---ERERIKAEQDKKIADE 291
EE +++ +EQ EKM EE++ R ++ R E E E+E EQ++K+ ++
Sbjct: 563 QEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQ 622
Query: 292 RARI-EAEEKAAAQERERREAEER----ERMREEEKRAAEERQRIKEEEK-----RAAEE 341
++ E EEK QE + E EE+ E E++R E+++++ E EK + E+
Sbjct: 623 EEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQ 682
Query: 342 RQRIKEE---EKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHA 398
++I E+ EK+ E+ ++ ++EK EE R E EK EE++ ++ EEK
Sbjct: 683 EEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMR----EREKKMREEEEMMREQEEK--- 735
Query: 399 MQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTF 458
MQE + EK++++ E W E+K E + + ++ E+K + + EK+QE + +
Sbjct: 736 MQEQE---EKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQK--EKLWEHEKMQEQEKIW 790
Query: 459 KKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRAS 518
++EE ++ +K + +E+++ ++ +G E
Sbjct: 791 EQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEE---------------------------- 822
Query: 519 VDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKV 578
K + + G+ E ++ K QE +E E+++ + E+ R
Sbjct: 823 ---------------KMWGQEEKMWGQEEKMWGQEEKMWGQEEKME-EKMQGQEEKMR-- 864
Query: 579 LEEEEQRRKQEEADRKLREEEEKRRLKEE 607
E+EE+ R QEE K+RE+EEK R +EE
Sbjct: 865 -EQEEKMRGQEE---KMREQEEKMRGQEE 889
Score = 124 bits (310), Expect = 4e-28
Identities = 141/582 (24%), Positives = 275/582 (47%), Gaps = 109/582 (18%)
Query: 140 DTAENETTEKEEKSESRQE----RYEIEETETVTK--SYQKNDWRDAEENKKEDKEKEEE 193
DT +N KEEK S Q R EIE + + + QK + A ++ K E+
Sbjct: 71 DTQQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFED 130
Query: 194 -------------------------------EEEKPKRGSI-------GENQ-------- 207
E K G + GE Q
Sbjct: 131 GNLGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGELQRALSAVST 190
Query: 208 ----VEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEE--- 260
+ +EE T E + + + L I++EE K++ Q ++ EK E +
Sbjct: 191 RHKKADRYIEELTKE--RDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNV 248
Query: 261 DKERAEAERARL------------EAEERERIKAEQDKKIADERARI-EAEEKAAAQERE 307
+ + + ERA+ E +E EQ+KKI + ++ EE+ QE +
Sbjct: 249 KELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGK 308
Query: 308 RREAEER-----ERMREEEKRAAE------ERQRIKEEEKRAAEERQRIKEEEKRAAEER 356
RE EE+ +R+RE+EK E E++ ++E+E++ E+ +++ E+E++ E+
Sbjct: 309 MREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQE 368
Query: 357 QRIKEEEKRAAEERQRARAEEEEKAKVEEQ--KRNKQLEEKKHAMQETKIKGEKVEQKIE 414
+++ +E+R E+ ++ R +E++ EE+ +++++L EK+ M+E + E+VE+ E
Sbjct: 369 EKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMRE 428
Query: 415 GKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEP 474
EKK QE + +T +++ +E+ +++ + +K++E++ T +++E EK++K +E
Sbjct: 429 -----EKKMQEQEKKTRDQEEKMQEE-ERIREREKKMREEEETMREQE---EKMQKQEEN 479
Query: 475 KEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGK 534
E + +++ E K + E K++ E + D +E G Q +
Sbjct: 480 MWEQEEKEWQQQRLPEQKEKLWE--QEKMQEQEEKIWEQEEKIR-DQEEMWG--QEKKMW 534
Query: 535 RLEELRRRRGETESEEFEKLKQKQQEAALELEELKKK-REERRKVLEEEEQRRKQE---E 590
R E++R + + +E EK++ ++Q+ + E ++KK +E+ +K ++EE+ R++E E
Sbjct: 535 RQEKMREQEDQMWEQE-EKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMRE 593
Query: 591 ADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKK 632
++K+REEEE R +EE + E EK Q+ E ++K
Sbjct: 594 REKKMREEEEMMREQEE---KMQEQEEKMQEQEEKMWEQEEK 632
Score = 119 bits (298), Expect = 1e-26
Identities = 108/422 (25%), Positives = 206/422 (48%), Gaps = 54/422 (12%)
Query: 14 KREEMRLEAERIAYQRND-DDEEEAARERRRRARQERLRQKQEE--ESLGQVTDQV---- 66
++E+M+ + E+I Q D+EE + ++ RQE++R+++++ E ++ DQ
Sbjct: 502 EQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMW 561
Query: 67 --EVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPT 124
E + ++E KT ++ ++ E+ R EE + +E ++ Q+E
Sbjct: 562 DQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEE---- 617
Query: 125 ITDASLSLPSRRMQNDTAENETTEKEEKSESRQER-YEIEETETVTKSYQKNDWRDAEEN 183
+MQ E + E+EEK + ++E+ +E EE K +++ + ++
Sbjct: 618 -----------KMQEQ--EEKMWEQEEKMQEQEEKMWEQEE-----KMWEQEEKMWEQQR 659
Query: 184 KKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEE 243
E KEK E E+ ++ + E + ++ +EK + +E + ++ EE +E E
Sbjct: 660 LPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMRERE 719
Query: 244 ----------REQGSDEISHHEKMEEEDKERAEAERARLEAEER--ERIKAEQDKKIADE 291
REQ EKM+E+++E E E E EE+ E+ + + K+ E
Sbjct: 720 KKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWE 779
Query: 292 RARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKR 351
+++ +EK QE + R+ EE+ R +EE+ R +E + +EEK +E + +EEK
Sbjct: 780 HEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMR-GQEEKMRGQEEKMWGQEEKMWGQEEKM 838
Query: 352 AAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQ 411
+E + +EEK EE+ + +EEK + +E+K Q E+K QE K++G+ E+
Sbjct: 839 WGQEEKMWGQEEK--MEEKMQG---QEEKMREQEEKMRGQ--EEKMREQEEKMRGQ--EE 889
Query: 412 KI 413
KI
Sbjct: 890 KI 891
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 174 bits (440), Expect = 4e-43
Identities = 138/544 (25%), Positives = 277/544 (50%), Gaps = 25/544 (4%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRND--DDEEEAARERRRRARQERLRQKQEEESLGQV 62
E+ +++R+Q+ E+M + ER+ Q + EE+ R+ +R QE+ ++QE+E +
Sbjct: 245 EQEKKIRKQE-EKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKE----L 299
Query: 63 TDQVEVNAQNS-VPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEF 121
+Q ++ Q + ++E K ++ +E + + E+ +Q R QE R +E
Sbjct: 300 REQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEE 359
Query: 122 DPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAE 181
D L RM+ E EK ++ E +ER + E T Q+ + E
Sbjct: 360 RMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQE 419
Query: 182 ENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQE 241
EN E +EKE +++ P++ Q ++ +E+ QEE + + + +QE
Sbjct: 420 ENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQE 479
Query: 242 EEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAE---QDKKIADERARIEAE 298
+ REQ EKM +++++ + E E +ER R K E + KK+ + ++ E
Sbjct: 480 KMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREE 539
Query: 299 EKAAAQERERREAEER----ERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAE 354
+K QE++ + EE+ ERMRE EK+ EE + ++E+E++ E+ ++++E+E++ E
Sbjct: 540 KKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWE 599
Query: 355 ERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKI--KGEKVEQK 412
+ ++++E+E++ E+ ++ E+EE+ K++EQ+ +E+K QE K+ + EK+ ++
Sbjct: 600 QEEKMQEQEEKMWEQEEK-MWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQ 658
Query: 413 IEGKWVNEKK--AQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEI--KDEKI 468
E E+K QE+K++ K QG+E+ + Q ++ + QE+K ++E++ ++EK+
Sbjct: 659 EEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKM 718
Query: 469 KKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDT---KEAE 525
+E +E+ + D+K+ E ++ E + SV+ + E
Sbjct: 719 WGQEEMREKEERIRDQKEKMQERLPEHEERCSEPCLPPSKVLCNMSHTGSVEPAGGEAGE 778
Query: 526 GAPQ 529
G+PQ
Sbjct: 779 GSPQ 782
Score = 167 bits (423), Expect = 4e-41
Identities = 151/585 (25%), Positives = 292/585 (49%), Gaps = 66/585 (11%)
Query: 104 EERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDT--AENETTE-----KEEKSESR 156
EE ++R +LE + TIT+ L + +Q AE+E +E KE K +
Sbjct: 162 EELTKERDALSLELYRN---TITNEELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLE 218
Query: 157 QERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGS-IGENQVEVMVEEK 215
+ ++ + + +T T Q+ WR EE ++++K+ ++EE+ ++ + E + ++ +E+
Sbjct: 219 RAKFLLPQVQTNT--LQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEE 276
Query: 216 TTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAE 275
QE+ + +QE+E + E+ +K+ E++++ E E E E
Sbjct: 277 KMRRQEKRL-------------REQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQE 323
Query: 276 ERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEE 335
E+ R EQ++K+ + EE+ QE++ RE E++ MR++E+R E+ +R++E+E
Sbjct: 324 EKMR---EQEEKMWRQ------EERLWEQEKQMREQEQK--MRDQEERMWEQDERLREKE 372
Query: 336 KRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEE---QKRNKQL 392
+R E+ + ++EEK +E +RI+E EK+ EE + R +EE+ K EE ++ K+
Sbjct: 373 ERMREQEKMWEQEEKM--QEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEW 430
Query: 393 EEKKHAMQETKI-KGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKL 451
++++ Q+ K+ + EK++++ E W E+K ++ + KK ++ + Q +
Sbjct: 431 QQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWE 490
Query: 452 QEDKPTFKKEEI---------KDEKIK-KDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTH 501
QE+K +++++ +DE+++ K++ +E+ K + +K E K+Q E T
Sbjct: 491 QEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTW 550
Query: 502 KLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEA 561
+ R R +E E + E + +E + R E + E E+ Q+Q+E
Sbjct: 551 DQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEK 610
Query: 562 ALELEELKKKREERRKVLEEE----EQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAE 617
E EE ++EE K+ E+E EQ K +E + K+ E+EEK R +EE + E E
Sbjct: 611 MWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEE---KMREQEE 667
Query: 618 KRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSG 662
K Q E ++K +G K+ E+ E + +K G
Sbjct: 668 KMQGQEEKMREQEEK------MQGQEEKMREQEEKMRGQEEKMWG 706
Score = 163 bits (413), Expect = 5e-40
Identities = 153/629 (24%), Positives = 307/629 (48%), Gaps = 70/629 (11%)
Query: 16 EEMRLEAERIAYQ--RNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNS 73
EE+ E + ++ + RN EE +++ QE+LR + E+S ++++N +
Sbjct: 162 EELTKERDALSLELYRNTITNEEL--KKKNAELQEKLRLAESEKS------EIQLNVKEL 213
Query: 74 VPD-EEAKTTTTNTQVEGDDEAAFL-ERLARREERRQKRLQEALERQKEFDPTITDASLS 131
E AK Q E + E R +E++ ++ +E + RQ+E
Sbjct: 214 KRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEE----------- 262
Query: 132 LPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEK- 190
R + + E EK + E R E E E + ++ R+ EE +E +EK
Sbjct: 263 ---RLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKM 319
Query: 191 -EEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSD 249
E+EE+ + + + + + +EK QE+ + + E +++EER + +
Sbjct: 320 WEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQE 379
Query: 250 EI-SHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERER 308
++ EKM+EE++ R ER + EE E ++ +++K E E EEK Q+R
Sbjct: 380 KMWEQEEKMQEEERIR---EREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLP 436
Query: 309 REAE---ERERMREEEKRAAEERQRIKEEEKRAAEER-----QRIKEEEKRAAEERQRIK 360
+ E E+E+M+E+E++ E+ ++I+++E+ +E+ ++++E+E + E+ ++++
Sbjct: 437 EQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMR 496
Query: 361 EEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGK-WVN 419
++E++ ++ +R ++E + EE+ R E+KK QE K++ EK Q+ E K W
Sbjct: 497 DQEQKMWDQEERMWEQDERLREKEERMR----EQKKMWQQEEKMREEKKTQEQEKKTWDQ 552
Query: 420 EKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIK----DEKIKKDKEPK 475
E+K +E++ KK EE+ ++ + EK+QE + +++E K +EK+++ +E
Sbjct: 553 EEKMREEERMREREKKMREEE-EMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKM 611
Query: 476 EEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKR 535
E + M ++ E K Q E M + + +E E + K
Sbjct: 612 WEQEEKMWEQE--EEDKMQEQEEMMWEQEEK--------------MQEQEEKMWEQEEKM 655
Query: 536 LEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKL 595
E+ + R + E + ++ K ++QE ++ +E +K RE+ K+ +EE+ QEE K+
Sbjct: 656 REQEEKMREQEEKMQGQEEKMREQEEKMQGQE-EKMREQEEKMRGQEEKMWGQEE---KM 711
Query: 596 REEEEKRRLKEEIERRRAEAAEKRQKMPE 624
+EEK +EE+ + ++++KM E
Sbjct: 712 WGQEEKMWGQEEMREKEERIRDQKEKMQE 740
Score = 160 bits (406), Expect = 3e-39
Identities = 132/509 (25%), Positives = 265/509 (52%), Gaps = 42/509 (8%)
Query: 156 RQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEE- 214
+ +RY IEE + +R+ N+ E K+K E +EK + ++++++ V+E
Sbjct: 156 KADRY-IEELTKERDALSLELYRNTITNE-ELKKKNAELQEKLRLAESEKSEIQLNVKEL 213
Query: 215 KTTESQEETVVMSLKNGQISSEEPKQEEE-REQGSDEISHHEKMEEEDKERAEAERARLE 273
K + + ++ ++ + E +QEEE REQ EKM +++ E E E
Sbjct: 214 KRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMRE 273
Query: 274 AEER----ERIKAEQDKKIADERARIEAEEKAAAQERERREAEER-----ERMREEEKRA 324
EE+ E+ EQ+K++ ++ + ++K QE + +E EE+ E+MRE+E++
Sbjct: 274 QEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKM 333
Query: 325 AEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVE 384
+ +R+ E+EK+ E+ Q+++++E+R E+ +R++E+E+R E Q E+EEK + E
Sbjct: 334 WRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMRE--QEKMWEQEEKMQEE 391
Query: 385 E--QKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKK--------AQEDKLQTAVLK 434
E ++R K++ E++ M+E + EK++++ E W E+K Q++KL
Sbjct: 392 ERIREREKKMREEEETMREQE---EKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKM 448
Query: 435 KQGEEK----GTKVQAKREKLQEDKPTFKKEEIK---DEKIKKDKEPKEEVKSFMDRKKG 487
++ EEK K++ + E ++K +++E+++ D+ +++++ +++ + D+++
Sbjct: 449 QEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEER 508
Query: 488 FTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETE 547
E + E + + R T+E E + K EE R R E +
Sbjct: 509 MWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKK 568
Query: 548 SEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQE----EADRKLREEEEKRR 603
E E++ ++Q+E E EE K RE+ K+ E+EE+ ++QE E + K+ E+EE+ +
Sbjct: 569 MREEEEMMREQEEKMQEQEE--KMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDK 626
Query: 604 LKEEIERRRAEAAEKRQKMPEDGLSDDKK 632
++E+ E E EK Q+ E ++K
Sbjct: 627 MQEQ-EEMMWEQEEKMQEQEEKMWEQEEK 654
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 167 bits (423), Expect = 4e-41
Identities = 150/575 (26%), Positives = 287/575 (49%), Gaps = 57/575 (9%)
Query: 71 QNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASL 130
+N++ DEE K Q ++ +E + K L+ LER K L
Sbjct: 211 RNTITDEELKEKNAKLQ----EKLQLVESEKSEIQLNVKELKRKLERAK----------L 256
Query: 131 SLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKND---WRDAEENKKED 187
LP +++Q AE + KE +S S + + ++EE E + Q+ + WR EE +E
Sbjct: 257 LLPQQQLQ---AEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQ-EEKIQEW 312
Query: 188 KEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQG 247
+EK +E+EEK I E + ++ +E+ QEE + + + E ++EE+ +
Sbjct: 313 EEKIQEQEEK-----IREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRR 367
Query: 248 SDEI--SHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQE 305
+E+ EKM +++ E E E EE K + +KI ++ + + EEK +E
Sbjct: 368 QEEMMWEKEEKMRRQEEMMWEKEEKIRELEE----KMHEQEKIREQEEKRQEEEKI--RE 421
Query: 306 RERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKR 365
+E+R+ +E + R+EEK E+ ++I+E+EK+ + ++I E+EK EE+++ +EE R
Sbjct: 422 QEKRQEQEAKMWRQEEK-IREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWR 480
Query: 366 AAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKG--EKVEQKIEGKWVNEKKA 423
E+ +K K+ EQ+ + +E+K QE KI+ EK+ ++ E W E+K
Sbjct: 481 QEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKI 540
Query: 424 QEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKD---------EKIKKDKEP 474
+E + +K E++ + KR++ QEDK ++E+I++ EKI++ +E
Sbjct: 541 REQEEMWREEEKMHEQEKIWEEEKRQE-QEDKMWRQEEKIREQEEKVWRQEEKIREQEEK 599
Query: 475 KEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGK 534
++E + M +++ + + + K++ E +E + Q E
Sbjct: 600 RQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQ--EEMTQEQEEKMGEQEEKMC 657
Query: 535 RLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQE----E 590
EE + + ET + EK+++++++ E+ +K RE+ + E+EE+ +QE E
Sbjct: 658 EQEEKMQEQEETMWRQEEKIREQEKKIR---EQEEKIREQEEMMQEQEEKMWEQEEKMCE 714
Query: 591 ADRKLREEEEK-RRLKEEIERRRAEAAEKRQKMPE 624
+ K++E+EEK RR +E++ + ++ +KM E
Sbjct: 715 QEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 749
Score = 158 bits (399), Expect = 2e-38
Identities = 106/479 (22%), Positives = 244/479 (50%), Gaps = 32/479 (6%)
Query: 1 MDDFERRRELRRQKREEMRLEAERIA-YQRNDDDEEEAARERRRRARQERLRQKQEEESL 59
+++ E L +Q+ E+M + E+I ++ ++EE RE+ + R++ + +++EE +
Sbjct: 285 VEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMM 344
Query: 60 GQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQK 119
+ +++ + EE E +++ E + +E + + L+E + Q+
Sbjct: 345 WEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQE 404
Query: 120 EFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRD 179
+ +R + + + +E++++ ++ +I E E + +K WR
Sbjct: 405 KI--------REQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQ 456
Query: 180 AEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPK 239
E+ +++K +EEE+ ++ Q E+ +E+ QEE K + + K
Sbjct: 457 EEKIHEQEKIREEEKRQE---------QEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRK 507
Query: 240 QEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEE---RERIKAEQDKKIADERARIE 296
QEE+ + ++I E+ E +E+ + ++ +E RE K + +KI +E R E
Sbjct: 508 QEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQE 567
Query: 297 AEEKAAAQERERREAEER-----ERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKR 351
E+K QE + RE EE+ E++RE+E++ E+ +++ ++E++ E+ ++I+E+E++
Sbjct: 568 QEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEK 627
Query: 352 AAEERQRIKEEEKRAAEERQRARAEE----EEKAKVEEQKRNKQLEEKKHAMQETKIK-- 405
E+ ++I+E+E+ E+ ++ +E E++ K++EQ+ +E+K QE KI+
Sbjct: 628 IREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQ 687
Query: 406 GEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIK 464
EK+ ++ E E+K E + + +++ +E+ K++ + EK+ E + +++E K
Sbjct: 688 EEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEK 746
Score = 133 bits (335), Expect = 6e-31
Identities = 152/608 (25%), Positives = 285/608 (46%), Gaps = 55/608 (9%)
Query: 51 RQKQEEESLGQVTD---QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERR 107
RQ + E+ Q+TD Q + + D + K T E E++
Sbjct: 56 RQSKLAEAKEQLTDHHPQTNPSVGTAASDTKKKKINNGTNPETTTSGGC--HSPEDEQKA 113
Query: 108 QKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETET 167
+ QEAL R+ E T L+ +Q ++ K+ + E+R + ++
Sbjct: 114 SHQHQEALRRELEAQ-VHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDSWK 172
Query: 168 VTKSYQKNDWRDAEENKKEDKEKEEEEEEKPK------RGSIGENQVEVMVEEKTTESQE 221
++ A + KK D+ EE +E+ R +I + +++ EK + QE
Sbjct: 173 FAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELK----EKNAKLQE 228
Query: 222 ETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDK--ERAEAERARLEAEERE- 278
+ ++ + +I + + + E+ + + E D + ++ A+L+A+ E
Sbjct: 229 KLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEEN 288
Query: 279 ----RIKAEQDKKIADERARI-EAEEKAAAQERERREAEERERMREEEKRAAEERQRIKE 333
R+ +Q++K+ + +I E EEK QE + RE EE+ R +EE+ R EE KE
Sbjct: 289 ELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKE 348
Query: 334 EEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEE--EEKAKVEEQKRNKQ 391
E+ R EE KEE+ R EE KEE+ R EE + E+ E + K+ EQ++ ++
Sbjct: 349 EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIRE 408
Query: 392 LEEKKHAMQETKIKGEKVEQKIEGK-WVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREK 450
EEK+ +E KI+ ++ Q+ E K W E+K +E + + +K+ + K+ ++EK
Sbjct: 409 QEEKRQ--EEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIH-EQEK 465
Query: 451 LQEDKPTFKKEEI--KDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTEN 508
++E++ ++EE+ ++EKI + +E + + ++++ +++ Q + + K E
Sbjct: 466 IREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEE---KIRKQEEKVWRQEEKIREQ 522
Query: 509 TFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEEL 568
+ +E + Q E + EE+ R + +E ++K+QE +E
Sbjct: 523 -------EEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQE-----QED 570
Query: 569 KKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEE----IERRRAEAAEKRQKMPE 624
K R+E K+ E+EE+ +QEE K+RE+EEKR+ +EE E + E EK Q+ E
Sbjct: 571 KMWRQEE-KIREQEEKVWRQEE---KIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEE 626
Query: 625 DGLSDDKK 632
++K
Sbjct: 627 KIREQEEK 634
Score = 130 bits (327), Expect = 5e-30
Identities = 100/403 (24%), Positives = 203/403 (50%), Gaps = 31/403 (7%)
Query: 4 FERRRELRRQK-----REEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEES 58
+E+ ++RRQ+ +EE E E +++ E+E R+ + R++ RQ+QE +
Sbjct: 373 WEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKM 432
Query: 59 LGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQ 118
Q + + ++E K ++ +E + R EE+RQ+ QE + RQ
Sbjct: 433 WRQ---------EEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQE--QEEMWRQ 481
Query: 119 KEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWR 178
+E + R+ + + E K+E+ RQE +I E E + ++ WR
Sbjct: 482 EEKIHEQEEIW-----RQKEKMHEQEEKIRKQEEKVWRQEE-KIREQEEKIREQEEKMWR 535
Query: 179 DAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEP 238
EE +E +E EEE+ ++ I E + E+K +E+ K + +
Sbjct: 536 Q-EEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIR 594
Query: 239 KQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAE 298
+QEE+R++ +++ E+ E +E+ + + ++ E+ E+I+ +++ E E E
Sbjct: 595 EQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIR-EQEEKIREQEEMTQEQEEKMGEQE 653
Query: 299 EKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQR 358
EK QE + +E EE M +E++ E+ ++I+E+E++ E+ + ++E+E++ E+ ++
Sbjct: 654 EKMCEQEEKMQEQEET--MWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEK 711
Query: 359 IKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQE 401
+ E+E++ E+ ++ R +EE+ E++ R +Q EEK MQE
Sbjct: 712 MCEQEEKMQEQEEKMRRQEEK--MWEQEVRLRQQEEK---MQE 749
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 147 bits (372), Expect = 3e-35
Identities = 147/537 (27%), Positives = 264/537 (49%), Gaps = 92/537 (17%)
Query: 71 QNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASL 130
+N++ DEE K Q ++ +E + K L+ LER K L
Sbjct: 211 RNTITDEELKEKNAKLQ----EKLQLVESEKSEIQLNVKELKRKLERAK----------L 256
Query: 131 SLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKND---WRDAEENKKED 187
LP +++Q AE + KE +S S + + ++EE E + Q+ + WR EE +E
Sbjct: 257 LLPQQQLQ---AEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQ-EEKIQEW 312
Query: 188 KEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQG 247
+EK +E+EEK I E + ++ +E+ QEE + + + E ++EE+ +
Sbjct: 313 EEKIQEQEEK-----IREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRR 367
Query: 248 SDEI--SHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQE 305
+E+ EK+ E +++ E E+ R + E+R+ +++KI ++ R E E K QE
Sbjct: 368 LEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQ-----EEEKIREQEKRQEQEAKMWRQE 422
Query: 306 RERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKR 365
+ RE EE+ +RE+EK+ + ++I E+EK I+EEEKR +E +EE+ R
Sbjct: 423 EKIREQEEK--IREQEKKMWRQEEKIHEQEK--------IREEEKRQEQEEMWRQEEKIR 472
Query: 366 AAEE--RQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKA 423
EE RQ+ + E+EK + +E+K +Q EEK H +E K+ ++ E W E+K
Sbjct: 473 EQEEIWRQKEKMHEQEKIRKQEEKVWRQ-EEKMHDQEE------KIREQEEKMWRQEEKI 525
Query: 424 QEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMD 483
+E + K++ + EK++E +EE+ E+ +K E +E+++
Sbjct: 526 REQE--------------EKIREQEEKIRE------QEEMMQEQEEKMGEQEEKMQEQEK 565
Query: 484 RKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRR 543
++ +++ Q + K K E +E + Q E + EE+ + +
Sbjct: 566 MRRQEEKIREQEEKIREQKEKIRE--------------QEEKIWEQEEKIREQEEMMQEQ 611
Query: 544 GETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEE 600
E E+ EK+ + Q+E E EE +++EE K+ E+E + R+QEE K++E +E
Sbjct: 612 EEKMWEQEEKMCE-QEEKMQEQEEKMRRQEE--KMWEQEVRLRQQEE---KMQEHQE 662
Score = 142 bits (359), Expect = 9e-34
Identities = 156/615 (25%), Positives = 279/615 (45%), Gaps = 52/615 (8%)
Query: 51 RQKQEEESLGQVTD---QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERR 107
RQ + E+ Q+TD Q + + D + K T E E++
Sbjct: 56 RQSKLAEAKEQLTDHHPQTNPSVGTAASDTKKKKINNGTNPETTTSGGC--HSPEDEQKA 113
Query: 108 QKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETET 167
+ QEAL R+ E T L+ +Q ++ K+ + E+R + ++
Sbjct: 114 SHQHQEALRRELEAQ-VHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDSWK 172
Query: 168 VTKSYQKNDWRDAEENKKEDKEKEEEEEEKPK------RGSIGENQVEVMVEEKTTESQE 221
++ A + KK D+ EE +E+ R +I + +++ EK + QE
Sbjct: 173 FAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELK----EKNAKLQE 228
Query: 222 ETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDK--ERAEAERARLEAEERE- 278
+ ++ + +I + + + E+ + + E D + ++ A+L+A+ E
Sbjct: 229 KLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEEN 288
Query: 279 ----RIKAEQDKKIADERARI-EAEEKAAAQERERREAEERERMREEEKRAAEERQRIKE 333
R+ +Q++K+ + +I E EEK QE + RE EE+ R +EE+ R EE KE
Sbjct: 289 ELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKE 348
Query: 334 EEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEER---QRARAEEEEKAKVEEQKRN- 389
E+ R EE KEE+ R EE KEE+ R EE+ Q E+EEK + EE+ R
Sbjct: 349 EKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQ 408
Query: 390 --KQLEEKKHAMQETKIKG--EKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQ 445
+Q +E K QE KI+ EK+ ++ + W E+K E + K+Q +E+ + +
Sbjct: 409 EKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQE 468
Query: 446 AK----------REKLQEDKPTFKKEE---IKDEKIKKDKEPKEEVKSFMDRKKGFTEVK 492
K +EK+ E + K+EE ++EK+ +E E + M R++ +
Sbjct: 469 EKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQ 528
Query: 493 SQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFE 552
+ K++ E + ++ E + E +R EE R + E E+ E
Sbjct: 529 EEKIREQEEKIREQEEMMQEQEEKMG---EQEEKMQEQEKMRRQEEKIREQEEKIREQKE 585
Query: 553 KLKQKQQEAALELEELKKKREERRKVLEEE--EQRRKQEEADRKLREEEEK-RRLKEEIE 609
K+++ Q+E E EE +++EE + EE+ EQ K E + K++E+EEK RR +E++
Sbjct: 586 KIRE-QEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMW 644
Query: 610 RRRAEAAEKRQKMPE 624
+ ++ +KM E
Sbjct: 645 EQEVRLRQQEEKMQE 659
Score = 140 bits (354), Expect = 4e-33
Identities = 109/431 (25%), Positives = 227/431 (52%), Gaps = 24/431 (5%)
Query: 48 ERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREE-- 105
+ L++K E L Q++ A + + ++ + QVE E RL +++E
Sbjct: 245 KELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVE---ENELWNRLNQQQEEK 301
Query: 106 --RRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIE 163
R+++++QE E+ +E + I + + + + E EKEEK ++E +
Sbjct: 302 MWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEM--MW 359
Query: 164 ETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEET 223
E E + ++ W + EE +E +EK E+E+ ++ + + ++ +EK QE+
Sbjct: 360 EKEEKMRRLEEMMW-EKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKR---QEQE 415
Query: 224 VVMSLKNGQISSEEPK---QEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERI 280
M + +I +E K QE++ + ++I EK+ EE+K + + E R E + RE+
Sbjct: 416 AKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQE 475
Query: 281 KAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAE 340
+ + K+ E+ +I +E+ ++ E+ +E E++RE+E++ + ++I+E+E++ E
Sbjct: 476 EIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQE-EKIREQEEKMWRQEEKIREQEEKIRE 534
Query: 341 ERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEE---EEKAKVEEQKRNKQLEEKKH 397
+ ++I+E+E+ E+ +++ E+E++ E+ + R EE E++ K+ EQK + +E+K
Sbjct: 535 QEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKI 594
Query: 398 AMQETKIK--GEKVEQKIEGKWVNEKK--AQEDKLQTAVLKKQGEEKGTKVQAKREKLQE 453
QE KI+ E ++++ E W E+K QE+K+Q K + +E+ Q R + QE
Sbjct: 595 WEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQE 654
Query: 454 DKPTFKKEEIK 464
+K +E ++
Sbjct: 655 EKMQEHQEHLE 665
Score = 136 bits (343), Expect = 7e-32
Identities = 131/571 (22%), Positives = 280/571 (49%), Gaps = 62/571 (10%)
Query: 104 EERRQKRLQEALER----QKEFDPTITDASLSLPSRRMQNDTAENETT--------EKEE 151
+E RQ +L EA E+ + +P++ A+ +++ N T TT ++++
Sbjct: 53 KETRQSKLAEAKEQLTDHHPQTNPSVGTAASDTKKKKINNGTNPETTTSGGCHSPEDEQK 112
Query: 152 KSESRQE--RYEIE------------ETETVTKSYQ--------KNDWRDAEENKKEDKE 189
S QE R E+E +TE Y + + RD + +
Sbjct: 113 ASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDSWK 172
Query: 190 KEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSD 249
E E+ + + + + +EE T E + + + L I+ EE K++ + Q
Sbjct: 173 FAGELEQALSAVATQKKKADRYIEELTKE--RDALSLELYRNTITDEELKEKNAKLQEKL 230
Query: 250 EISHHEKMEEE---DKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQER 306
++ EK E + + + + ERA+L +++ ++AE D + E + A+ +A +E
Sbjct: 231 QLVESEKSEIQLNVKELKRKLERAKLLLPQQQ-LQAEADH-LGKELQSVSAKLQAQVEEN 288
Query: 307 E---RREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEE 363
E R ++ E+M +E++ E ++I+E+E++ E+ ++I+E+E++ + + + E+E
Sbjct: 289 ELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKE 348
Query: 364 KRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKA 423
++ + + +EE+ ++EE K EEK ++E + EK+ ++ E + EK
Sbjct: 349 EKMRRQEEMMWEKEEKMRRLEEMMWEK--EEKIRELEEKMHEQEKIREQEEKRQEEEKIR 406
Query: 424 QEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKD-EKIKKDKEPKEEVKSFM 482
+++K Q K +E+ + Q ++ + QE K ++E+I + EKI+++++ +E+ + +
Sbjct: 407 EQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWR 466
Query: 483 DRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRR 542
+K ++ Q + + H + + V +E + Q E + EE R
Sbjct: 467 QEEK----IREQEEIWRQKEKMHEQEKIRKQ--EEKVWRQEEKMHDQEEKIREQEEKMWR 520
Query: 543 RGETESEEFEKLKQKQQEAALELEELKKKREER-----RKVLEEEEQRRKQE---EADRK 594
+ E E+ EK+++ Q+E E EE+ +++EE+ K+ E+E+ RR++E E + K
Sbjct: 521 QEEKIREQEEKIRE-QEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEK 579
Query: 595 LREEEEKRRLKEEIERRRAEAAEKRQKMPED 625
+RE++EK R +EE + E ++++M ++
Sbjct: 580 IREQKEKIREQEEKIWEQEEKIREQEEMMQE 610
Score = 136 bits (342), Expect = 9e-32
Identities = 95/415 (22%), Positives = 210/415 (50%), Gaps = 51/415 (12%)
Query: 1 MDDFERRRELRRQKREEMRLEAERIA-YQRNDDDEEEAARERRRRARQERLRQKQEEESL 59
+++ E L +Q+ E+M + E+I ++ ++EE RE+ + R++ + +++EE +
Sbjct: 285 VEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMM 344
Query: 60 GQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQK 119
+ EE E +++ LE + +E + + L+E + Q+
Sbjct: 345 WE--------------KEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQE 390
Query: 120 EFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRD 179
+ +R + + + +E++++ ++ +I E E + +K WR
Sbjct: 391 KIREQ--------EEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQ 442
Query: 180 AEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPK 239
E+ +++K +EEE+ ++ Q E+ +E+ QEE + K E+ +
Sbjct: 443 EEKIHEQEKIREEEKRQE---------QEEMWRQEEKIREQEE--IWRQKEKMHEQEKIR 491
Query: 240 QEEEREQGSDEISHHEK---MEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIE 296
++EE+ +E H ++ E+E+K + E+ R E+ E+I+ +++K E E
Sbjct: 492 KQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIR---EQEEKIREQEEKIREQEEMMQE 548
Query: 297 AEEKAAAQERERREAE----ERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRA 352
EEK QE + +E E + E++RE+E++ E++++I+E+E++ E+ ++I+E+E+
Sbjct: 549 QEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMM 608
Query: 353 AEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQK------RNKQLEEKKHAMQE 401
E+ +++ E+E++ E+ ++ + E+EEK + +E+K R +Q EEK QE
Sbjct: 609 QEQEEKMWEQEEKMCEQEEKMQ-EQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQE 662
Score = 133 bits (334), Expect = 7e-31
Identities = 117/461 (25%), Positives = 235/461 (50%), Gaps = 55/461 (11%)
Query: 5 ERRRELRRQKREEMRL-EAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVT 63
E +E + +E+++L E+E+ Q N + + + Q++L+ E + LG+
Sbjct: 217 EELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQA--EADHLGKEL 274
Query: 64 DQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQK---RLQEALERQKE 120
V Q V + E N Q E E++ R+EE+ Q+ ++QE E+ +E
Sbjct: 275 QSVSAKLQAQVEENEL-WNRLNQQQE--------EKMWRQEEKIQEWEEKIQEQEEKIRE 325
Query: 121 FDPTITDASLSLPSRRMQNDTAENETT---------EKEEKSESRQER-YEIEET--ETV 168
+ I + + RR + E E EKEEK +E +E EE E
Sbjct: 326 QEEKIREQEEKM--RRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELE 383
Query: 169 TKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSL 228
K +++ R+ EE ++E+++ E+E+ + + + + ++ +E+ QE+ M
Sbjct: 384 EKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKK--MWR 441
Query: 229 KNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKI 288
+ +I +E +EEE+ Q +E+ + EE+ +E+ E R + + E+E+I+ +++K
Sbjct: 442 QEEKIHEQEKIREEEKRQEQEEMW---RQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVW 498
Query: 289 ADERARIEAEEKAAAQE-----RERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQ 343
E + EEK QE +E + E+ E++RE+E++ E+ + ++E+E++ E+ +
Sbjct: 499 RQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEE 558
Query: 344 RIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEE------EKAKVEEQKRNKQLE---- 393
+++E+EK +E ++I+E+E++ E++++ R +EE EK + +E+ +Q E
Sbjct: 559 KMQEQEKMRRQE-EKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWE 617
Query: 394 -EKKHAMQETKI--KGEKVEQKIEGKWVNE--KKAQEDKLQ 429
E+K QE K+ + EK+ ++ E W E + QE+K+Q
Sbjct: 618 QEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQ 658
Score = 81.3 bits (199), Expect = 3e-15
Identities = 92/406 (22%), Positives = 191/406 (47%), Gaps = 39/406 (9%)
Query: 271 RLEAEERERIKAEQDK-KIADERARIEAEEKAAAQERERREAEERERMREEEKRAAE-ER 328
+LE E R+ I D K A E +E A A ++++ + E +E + + E R
Sbjct: 155 QLEGEARDLISRLHDSWKFAGE---LEQALSAVATQKKKADRYIEELTKERDALSLELYR 211
Query: 329 QRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAE-EEEKAKVEEQK 387
I +EE + E+ +++E+ + E+ I+ K + +RA+ +++ + E
Sbjct: 212 NTITDEELK--EKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADH 269
Query: 388 RNKQLEEKKHAMQ----ETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTK 443
K+L+ +Q E ++ +Q+ E W E+K QE +++ +E+ K
Sbjct: 270 LGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQE-------WEEKIQEQEEK 322
Query: 444 VQAKREKLQEDKPTFKKEEI----KDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFM 499
++ + EK++E + +++E K+EK+++ +E E + M R + K + +
Sbjct: 323 IREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIREL 382
Query: 500 THKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQ 559
K+ E R + ++ E + + ++ +E + R E + E E+ K ++Q
Sbjct: 383 EEKMHEQEKI------REQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEE-KIREQ 435
Query: 560 EAALELEELKKKREERRKVLEEEEQRRKQEE---ADRKLREEEEKRRLKEEI-ERRRAEA 615
E + +E K +E+ + EEE+R++QEE + K+RE+EE R KE++ E+ +
Sbjct: 436 EKKMWRQEEKIHEQEK---IREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRK 492
Query: 616 AEKRQKMPEDGLSDDKKPFKCFTPK--GSSLKIEERAEFLNKSVQK 659
E++ E+ + D ++ + K KI E+ E + + +K
Sbjct: 493 QEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEK 538
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 146 bits (368), Expect = 8e-35
Identities = 158/614 (25%), Positives = 284/614 (46%), Gaps = 55/614 (8%)
Query: 51 RQKQEEESLGQVTD---QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERR 107
RQ + E+ Q+TD Q + + D + K T E E++
Sbjct: 117 RQSKLAEAKEQLTDHHPQTNPSVGTAASDTKKKKINNGTNPETTTSGGC--HSPEDEQKA 174
Query: 108 QKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETET 167
+ QEAL R+ E T L+ +Q ++ K+ + E+R + ++
Sbjct: 175 SHQHQEALRRELEAQ-VHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDSWK 233
Query: 168 VTKSYQKNDWRDAEENKKEDKEKEEEEEEKPK------RGSIGENQVEVMVEEKTTESQE 221
++ A + KK D+ EE +E+ R +I + +++ EK + QE
Sbjct: 234 FAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELK----EKNAKLQE 289
Query: 222 ETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDK--ERAEAERARLEAEERE- 278
+ ++ + +I + + + E+ + + E D + ++ A+L+A+ E
Sbjct: 290 KLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEEN 349
Query: 279 ----RIKAEQDKKIADERARI-EAEEKAAAQERERREAEERERMREEEKRAAEERQRIKE 333
R+ +Q++K+ + +I E EEK QE + RE EE+ R +EE+ R EE KE
Sbjct: 350 ELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKE 409
Query: 334 EEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEER---QRARAEEEEKAKVEEQKRN- 389
E+ R EE KEE+ R EE KEE+ R EE+ Q E+EEK + EE+ R
Sbjct: 410 EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQ 469
Query: 390 --KQLEEKKHAMQETKIKG--EKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQ 445
+Q +E K QE KI+ EK+ ++ E W E+K E + K+Q +E+ + +
Sbjct: 470 EKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQE 529
Query: 446 AK----------REKLQEDKPTFKKEEIK----DEKIKKDKEPKEEVKSFMDRKKGFTEV 491
K +EK+ E + +K+E K +EK+ +E E + + R++ ++
Sbjct: 530 EKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQE--EKI 587
Query: 492 KSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEF 551
+ Q + + K E + +E + Q E + EE RR+ E E+
Sbjct: 588 REQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQE 647
Query: 552 EKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEK-RRLKEEIER 610
+K+++ Q+E E EE+ +++EE K+ E+EE+ +QEE K++E+EEK RR +E++
Sbjct: 648 KKIRE-QEEKIREQEEMMQEQEE--KMWEQEEKMCEQEE---KMQEQEEKMRRQEEKMWE 701
Query: 611 RRAEAAEKRQKMPE 624
+ ++ +KM E
Sbjct: 702 QEVRLRQQEEKMQE 715
Score = 145 bits (367), Expect = 1e-34
Identities = 146/547 (26%), Positives = 258/547 (47%), Gaps = 110/547 (20%)
Query: 71 QNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASL 130
+N++ DEE K Q ++ +E + K L+ LER K L
Sbjct: 272 RNTITDEELKEKNAKLQ----EKLQLVESEKSEIQLNVKELKRKLERAK----------L 317
Query: 131 SLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKND---WRDAEENKKED 187
LP +++Q AE + KE +S S + + ++EE E + Q+ + WR EE +E
Sbjct: 318 LLPQQQLQ---AEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQ-EEKIQEW 373
Query: 188 KEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQG 247
+EK +E+EEK + EEK E +E+ +QEE +
Sbjct: 374 EEKIQEQEEKIREQ-----------EEKIREQEEKM--------------RRQEEMMWEK 408
Query: 248 SDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERE 307
+++ E+M E +E+ + E + E+++KI + ++ +EK QE +
Sbjct: 409 EEKMRRQEEMMWEKEEKMRRQ---------EEMMWEKEEKIRELEEKMHEQEKIREQEEK 459
Query: 308 RREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEK-RA 366
R +E E++RE+EKR +E + ++EEK E+ ++I+E+E++ + ++I E+EK R
Sbjct: 460 R---QEEEKIREQEKRQEQEAKMWRQEEK-IREQEEKIREQEEKMWRQEEKIHEQEKIRE 515
Query: 367 AEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKA--Q 424
E+RQ ++ K+ EQ+ + +EK H +E K+ ++ E W E+K Q
Sbjct: 516 EEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEE------KIRKQEEKMWRQEEKMHDQ 569
Query: 425 EDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDR 484
E+K++ E+ KV + EK++E + +++E EKI++ +E +E +
Sbjct: 570 EEKIR---------EQEEKVWRQEEKIREQEEKIREQE---EKIREQEEMTQE----QEE 613
Query: 485 KKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRG 544
K G E K E K++ E R E R +E + R
Sbjct: 614 KMGEQEEKMCEQE---EKMQEQEEKMRRQ-----------------EEKIREQEKKIREQ 653
Query: 545 ETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQE----EADRKLREEEE 600
E + E E++ Q+Q+E E EE K E+ K+ E+EE+ R+QE E + +LR++EE
Sbjct: 654 EEKIREQEEMMQEQEEKMWEQEE--KMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEE 711
Query: 601 KRRLKEE 607
K + +E
Sbjct: 712 KMQEHQE 718
Score = 141 bits (356), Expect = 2e-33
Identities = 113/429 (26%), Positives = 229/429 (53%), Gaps = 25/429 (5%)
Query: 48 ERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREE-- 105
+ L++K E L Q++ A + + ++ + QVE E RL +++E
Sbjct: 306 KELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVE---ENELWNRLNQQQEEK 362
Query: 106 --RRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIE 163
R+++++QE E+ +E + I + + + + E EKEEK RQE E
Sbjct: 363 MWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMR-RQEEMMWE 421
Query: 164 ETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEET 223
+ E + + Q+ + EE +E +EK E+E+ ++ + + ++ +EK QE+
Sbjct: 422 KEEKMRR--QEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKR---QEQE 476
Query: 224 VVMSLKNGQISSEEPK---QEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERI 280
M + +I +E K QEE+ + ++I EK+ EE+K + + E R E + RE+
Sbjct: 477 AKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQE 536
Query: 281 KA-EQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAA 339
+ Q +KI ++ +I +E+ ++ E+ +E E++RE+E++ + ++I+E+E++
Sbjct: 537 EIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQE-EKIREQEEKVWRQEEKIREQEEKIR 595
Query: 340 EERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAM 399
E+ ++I+E+E+ E+ +++ E+E++ E+ ++ + E+EEK + +E+K +Q EKK
Sbjct: 596 EQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQ-EQEEKMRRQEEKIREQ--EKKIRE 652
Query: 400 QETKIK--GEKVEQKIEGKWVNEKK--AQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDK 455
QE KI+ E ++++ E W E+K QE+K+Q K + +E+ Q R + QE+K
Sbjct: 653 QEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEK 712
Query: 456 PTFKKEEIK 464
+E ++
Sbjct: 713 MQEHQEHLE 721
Score = 133 bits (335), Expect = 6e-31
Identities = 119/455 (26%), Positives = 232/455 (50%), Gaps = 48/455 (10%)
Query: 5 ERRRELRRQKREEMRL-EAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVT 63
E +E + +E+++L E+E+ Q N + + + Q++L+ E + LG+
Sbjct: 278 EELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQA--EADHLGKEL 335
Query: 64 DQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQK---RLQEALERQKE 120
V Q V + E N Q E E++ R+EE+ Q+ ++QE E+ +E
Sbjct: 336 QSVSAKLQAQVEENEL-WNRLNQQQE--------EKMWRQEEKIQEWEEKIQEQEEKIRE 386
Query: 121 FDPTITDASLSLPSRRMQNDTAENETT---------EKEEKSESRQER-YEIEET--ETV 168
+ I + + RR + E E EKEEK ++E +E EE E
Sbjct: 387 QEEKIREQEEKM--RRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELE 444
Query: 169 TKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSL 228
K +++ R+ EE ++E+++ E+E+ + + + + ++ +E+ QEE M
Sbjct: 445 EKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEK--MWR 502
Query: 229 KNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAE----Q 284
+ +I +E +EEE+ Q +E+ E+ E +E + E EE+ R + E Q
Sbjct: 503 QEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQ 562
Query: 285 DKKIADERARI-EAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQ 343
++K+ D+ +I E EEK QE + RE EE+ +RE+E++ E+ + +E+E++ E+ +
Sbjct: 563 EEKMHDQEEKIREQEEKVWRQEEKIREQEEK--IREQEEKIREQEEMTQEQEEKMGEQEE 620
Query: 344 RIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLE-----EKKHA 398
++ E+E++ E+ ++++ +E++ E+ ++ R E+EEK + +E+ +Q E E+K
Sbjct: 621 KMCEQEEKMQEQEEKMRRQEEKIREQEKKIR-EQEEKIREQEEMMQEQEEKMWEQEEKMC 679
Query: 399 MQETKI--KGEKVEQKIEGKWVNE--KKAQEDKLQ 429
QE K+ + EK+ ++ E W E + QE+K+Q
Sbjct: 680 EQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQ 714
Score = 132 bits (331), Expect = 2e-30
Identities = 96/408 (23%), Positives = 204/408 (50%), Gaps = 42/408 (10%)
Query: 1 MDDFERRRELRRQKREEMRLEAERIA-YQRNDDDEEEAARERRRRARQERLRQKQEEESL 59
+++ E L +Q+ E+M + E+I ++ ++EE RE+ + R++ + +++EE +
Sbjct: 346 VEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMM 405
Query: 60 GQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQK 119
+ +++ + EE E + E++ EE+ + QE + Q+
Sbjct: 406 WEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKE------EKIRELEEKMHE--QEKIREQE 457
Query: 120 EFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRD 179
E R+ + E E +++E RQE +I E E + ++ WR
Sbjct: 458 E-------------KRQEEEKIREQEKRQEQEAKMWRQEE-KIREQEEKIREQEEKMWRQ 503
Query: 180 AEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPK 239
E+ +++K +EEE+ ++ Q E+ +E+ QEE K + + K
Sbjct: 504 EEKIHEQEKIREEEKRQE---------QEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRK 554
Query: 240 QEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEE 299
QEE+ + +++ E+ E +E+ + ++ E+ E+I+ +++K E E EE
Sbjct: 555 QEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIR-EQEEKIREQEEKIREQEEMTQEQEE 613
Query: 300 KAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRI 359
K E+E + E+ E+M+E+E++ + ++I+E+EK+ E+ ++I+E+E+ E+ +++
Sbjct: 614 KMG--EQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKM 671
Query: 360 KEEEKRAAEERQRARAEEEEKAKVEEQK------RNKQLEEKKHAMQE 401
E+E++ E+ ++ + E+EEK + +E+K R +Q EEK QE
Sbjct: 672 WEQEEKMCEQEEKMQ-EQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQE 718
Score = 129 bits (323), Expect = 1e-29
Identities = 133/601 (22%), Positives = 285/601 (47%), Gaps = 89/601 (14%)
Query: 104 EERRQKRLQEALER----QKEFDPTITDASLSLPSRRMQNDTAENETT--------EKEE 151
+E RQ +L EA E+ + +P++ A+ +++ N T TT ++++
Sbjct: 114 KETRQSKLAEAKEQLTDHHPQTNPSVGTAASDTKKKKINNGTNPETTTSGGCHSPEDEQK 173
Query: 152 KSESRQE--RYEIE------------ETETVTKSYQ--------KNDWRDAEENKKEDKE 189
S QE R E+E +TE Y + + RD + +
Sbjct: 174 ASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDSWK 233
Query: 190 KEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSD 249
E E+ + + + + +EE T E + + + L I+ EE K++ + Q
Sbjct: 234 FAGELEQALSAVATQKKKADRYIEELTKE--RDALSLELYRNTITDEELKEKNAKLQEKL 291
Query: 250 EISHHEKMEEE---DKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQER 306
++ EK E + + + + ERA+L +++ ++AE D + E + A+ +A +E
Sbjct: 292 QLVESEKSEIQLNVKELKRKLERAKLLLPQQQ-LQAEADH-LGKELQSVSAKLQAQVEEN 349
Query: 307 E---RREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEE 363
E R ++ E+M +E++ E ++I+E+E++ E+ ++I+E+E++ + + + E+E
Sbjct: 350 ELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKE 409
Query: 364 KRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKA 423
++ + + +EE+ + EE K EEK ++E + EK+ ++ E + EK
Sbjct: 410 EKMRRQEEMMWEKEEKMRRQEEMMWEK--EEKIRELEEKMHEQEKIREQEEKRQEEEKIR 467
Query: 424 QEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKD-EKIKKDKEPKEEVKSFM 482
+++K Q K +E+ + Q ++ + QE+K ++E+I + EKI+++++ +E+ + +
Sbjct: 468 EQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWR 527
Query: 483 DRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRR 542
+K ++ Q E K K E Q E ++ EE R
Sbjct: 528 QEEK----IREQE-EIWRQKEKIHE---------------------QEEKIRKQEEKMWR 561
Query: 543 RGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQE----EADRKLREE 598
+ E ++ EK+++++++ + E++ RE+ K+ E+EE+ R+QE E + K+ E+
Sbjct: 562 QEEKMHDQEEKIREQEEKVWRQEEKI---REQEEKIREQEEKIREQEEMTQEQEEKMGEQ 618
Query: 599 EEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQ 658
EEK +EE + + E++ + E+ + + +K + KI E+ E + + +
Sbjct: 619 EEKMCEQEE----KMQEQEEKMRRQEEKIREQEKKI-----REQEEKIREQEEMMQEQEE 669
Query: 659 K 659
K
Sbjct: 670 K 670
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 144 bits (363), Expect = 3e-34
Identities = 154/665 (23%), Positives = 306/665 (46%), Gaps = 64/665 (9%)
Query: 15 REEMRLEAERIAYQRND------DDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEV 68
+ E+ LE RI D E EAAR+R+ A +ER R++ EE + + E
Sbjct: 1941 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA 2000
Query: 69 NAQNSVPDEEAKTTTTNTQV------EGDDEAAFLERLARREERRQKRLQE--------A 114
Q EE + + + E+A +LA +E QKRLQ
Sbjct: 2001 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA--QEAAQKRLQAEEKAHAFAV 2058
Query: 115 LERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEE-----KSESRQERYEIEETETVT 169
++++E T+ L R + + A E EE + E+ Q R ++EE E +
Sbjct: 2059 QQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK 2118
Query: 170 KSYQKNDWRDAEENKKEDKEKEEEEEEKPKRG-----SIGENQVEVMVEEKTTESQEETV 224
+S ++ A+ +K ++E E+E +R ++ + Q EK + E+T+
Sbjct: 2119 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2178
Query: 225 VMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQ 284
+ Q + Q EE + + + E+++ E EA R R + EE Q
Sbjct: 2179 RQKAQVEQELTTLRLQLEETDHQKNLLD--EELQRLKAEATEAARQRSQVEEELFSVRVQ 2236
Query: 285 DKKIADERARIEAEEKAA-------AQERERREAEERERMREEEKR---AAEERQRIKE- 333
++++ +ARIEAE +A Q + EAE+ +++ EE R AA+E R+++
Sbjct: 2237 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2296
Query: 334 EEKRAAEER---QRIKEEEKRAAEERQRIKEE------EKRAAEERQRARAEEEEKAKV- 383
E+ A++R +++ +E+ +A +E R+K E +K A+E+ R E++E+
Sbjct: 2297 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ 2356
Query: 384 ---EEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEK 440
E Q + LE ++ E + E+++ ++ + +A+ED + +KQ EE
Sbjct: 2357 LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR---FRKQAEEI 2413
Query: 441 GTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMT 500
G K+ QE + EI+ ++ D E E + ++R+K + +++ + +
Sbjct: 2414 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS 2473
Query: 501 HKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQE 560
+++ + +A + +E ++ + +E+ + + + +E K +Q ++E
Sbjct: 2474 EEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE 2533
Query: 561 AALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAE-AAEKR 619
+ ++++++R+ R V EE RR+Q EA+ +R ++E+ + E+ R++ E AE+
Sbjct: 2534 QQRQQQQMEQERQ--RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEEN 2591
Query: 620 QKMPE 624
Q++ E
Sbjct: 2592 QRLRE 2596
Score = 137 bits (346), Expect = 3e-32
Identities = 171/744 (22%), Positives = 340/744 (45%), Gaps = 106/744 (14%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDD--------------------EEEAARERRRRA 45
R+REL Q+ E+ R AE A QR + EEE AR +R A
Sbjct: 1685 RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA 1744
Query: 46 RQERLRQKQEEESLGQVTDQVEVN-AQNSVPDEEAKTTTTNTQV----------EGDDEA 94
+ RQ+ E E L +V ++EV A + +EE+++T+ ++ E +EA
Sbjct: 1745 AATQKRQELEAE-LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1803
Query: 95 AFLERLARREERRQKRLQEALERQK---------------EFDPTITDASLSLPSRRMQN 139
A L LA +R+++ +E RQ+ E T+A ++L + +N
Sbjct: 1804 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1863
Query: 140 DT----AENETTEKEEKSE-SRQERYEIEETETVTKSYQKNDWRD----AEENKKEDKEK 190
+ AE+E ++ E + Q + +IEE + ++ E+ ++ ++
Sbjct: 1864 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1923
Query: 191 EEEE---EEKPKRGSIGENQVEVMV------EEKTTESQEETVVMSLKNGQISSEEPKQE 241
EEE + ++ + G+ ++E+ + E T S+E+ + + + Q+++EE ++
Sbjct: 1924 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 1983
Query: 242 EEREQ-------GSDEISHHEK--MEEEDKERAEAERARLEAEERERIKAEQDKKIADER 292
E E+ +E + K +EE ++ +A+ E AR E E+ A Q ++A E
Sbjct: 1984 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ-LQLAQEA 2042
Query: 293 A--RIEAEEKAAAQERERREAEERERMREEE------KRAAEERQRIKEEEKRAAEERQR 344
A R++AEEKA A +++E E ++ +++E+ + AE +R EE + A + +R
Sbjct: 2043 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2102
Query: 345 IKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKI 404
+ +R EE +R+K+ + A+ R +A+A E+ K EQ+ ++ + ++ A+++ +
Sbjct: 2103 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2162
Query: 405 KGEKVE--QKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEE 462
++E +K + + +K E +L T L+ Q EE + E+LQ K
Sbjct: 2163 ADAEMEKHKKFAEQTLRQKAQVEQELTT--LRLQLEETDHQKNLLDEELQRLKAE----- 2215
Query: 463 IKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQ-NGEFMTHKLKHTENTFSRPGGRASVDT 521
E ++ + +EE+ S + + +++K++ E L+ +NT A
Sbjct: 2216 -ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2274
Query: 522 KEAEGAPQV----EAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKRE--ER 575
+ AE A ++ + RL +L + EK+ +++ +A E LK + E ++
Sbjct: 2275 QVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2334
Query: 576 RKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFK 635
+K L +E+ RR QE+ +E+ ++L EE + + +RQ+ E ++ +
Sbjct: 2335 QKELAQEQARRLQED------KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR 2388
Query: 636 CFTPKGSSLKIEERAEFLNKSVQK 659
+ + EE A+ K ++
Sbjct: 2389 VAEMSRAQARAEEDAQRFRKQAEE 2412
Score = 129 bits (323), Expect = 1e-29
Identities = 193/835 (23%), Positives = 344/835 (41%), Gaps = 151/835 (18%)
Query: 9 ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRR---------RARQER----LRQKQE 55
E R+ EE RL ++ A +R E EAA E++R +A+ ER L+Q+ +
Sbjct: 1339 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1398
Query: 56 EESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVE-----GDDEAAFLERLARREERRQKR 110
EE + + V+ Q EE + +++ E EAA RL EE R R
Sbjct: 1399 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1458
Query: 111 LQ-EALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIE-----E 164
LQ EA ERQ+ A L + R + + AE + + +E++E + + + E +
Sbjct: 1459 LQLEATERQRG------GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1512
Query: 165 TETVTKSYQKNDWRDAEENKK-----EDKEKEEEEEEKPKRGSIGEN--QVEVMVE---- 213
E S K + A E ++ E+ + EE E+ R + E QV+V +E
Sbjct: 1513 AEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1572
Query: 214 --------------EKTTE-----SQEETVVMSLKNG-------QISSEEPKQEEERE-- 245
EKT + +E V L+ Q +E ++E ERE
Sbjct: 1573 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1632
Query: 246 ---------------------QGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQ 284
Q S + EK +EE + A E R+R AEQ
Sbjct: 1633 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1692
Query: 285 DKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQR 344
+ + + A A+++ AA++ R E E+ ++ + EE R++ E A ++RQ
Sbjct: 1693 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1752
Query: 345 IKEEEKRAAEERQRI------KEEEKRAAEERQRARAEEEE-------------KAKVEE 385
++ E + E + + EEE R+ E+ + R E E +A EE
Sbjct: 1753 LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE 1812
Query: 386 QKRNKQLEEKKHAMQETKIK----------GEKVEQKIEGK-WVNEKKAQEDKLQTAVLK 434
KR +QL E+ A Q + + GE K E + + EK+A+ ++L+
Sbjct: 1813 AKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1872
Query: 435 KQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQ 494
+ + + + QA + K ++ + + D ++++ K E+ + R++ E+ +
Sbjct: 1873 EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED--TLRQRRQVEEEILAL 1930
Query: 495 NGEFMTHKLKHTENTFSRPGGRASV-DTKEAEGAPQVEAGKR----LEELRRRRGETE-- 547
F E R++ DT ++ ++EA ++ EE RRRR E
Sbjct: 1931 KASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV 1990
Query: 548 --SEEFEKLKQKQQEAAL-ELEELKKKREERRKVLEEEEQ------RRKQEEADRKLREE 598
S E+ +Q++AAL E+E LK K EE R++ E EQ + QE A ++L+ E
Sbjct: 1991 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2050
Query: 599 EEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIE----------- 647
E+ + + + + ++++ D L + + + + +++
Sbjct: 2051 EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2110
Query: 648 -ERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASD 701
E AE L +S ++ + ++ QAA K+ EQ + + A + A+D
Sbjct: 2111 VEEAERLKQSAEEQAQARAQAQAA-AEKLRKEAEQEAARRAQAEQAALRQKQAAD 2164
Score = 127 bits (320), Expect = 3e-29
Identities = 187/796 (23%), Positives = 348/796 (43%), Gaps = 194/796 (24%)
Query: 14 KREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNS 73
++ + RLEAE ++ + EEAAR R +R RQ EE++ Q + V A+
Sbjct: 1783 EKSKQRLEAEAGRFR---ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1839
Query: 74 VPDEEAKTTTTNTQV---EGDDEAAFLERLARREERRQKRLQE-ALERQKEFDPTI---- 125
EA T ++ E + E L RLA E +++RL+E A + + + + +
Sbjct: 1840 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1899
Query: 126 --TDASLSLPSRRMQNDTAENETTEKE--------EKSESRQERYEIE------ETETVT 169
+D+ L +++ + E+E EK+ + + E+E E
Sbjct: 1900 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1959
Query: 170 KSYQKNDWRDA--------EENKKEDKEKE-------EEEEEKPKRGSIGE-NQVEVMVE 213
+S ++ + A EE ++ + E+ EEE + ++ ++ E +++ VE
Sbjct: 1960 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 2019
Query: 214 E--KTTESQEETVVMSLKNGQISSEEPKQEEER------EQGSDEISHHEKMEEE--DKE 263
E + E E+ L+ Q ++++ Q EE+ +Q E+ + E+ D+
Sbjct: 2020 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2079
Query: 264 RAEAERARLEAEERERIKAEQDKKIADERARIE--------AEEKA-------AAQERER 308
R EAE AR AEE E + + +++ A R ++E AEE+A AA E+ R
Sbjct: 2080 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2139
Query: 309 REAEERERMREEEKRAAEERQRIKEEE----KRAAEE--RQRIKEEEKRAA--------- 353
+EAE+ R + ++AA +++ + E K+ AE+ RQ+ + E++
Sbjct: 2140 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2199
Query: 354 -------EERQRIKEEEKRAAEERQRARAEEEE-------------KAKVEEQKRNKQLE 393
EE QR+K E AA RQR++ EEE KA++E + R L
Sbjct: 2200 HQKNLLDEELQRLKAEATEAA--RQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2257
Query: 394 EKKHAMQETKIKGEKVEQKIEG---------------KWVNEKKAQEDKLQTAVLKK--Q 436
+K + + + + EK++Q E + E AQ+ L +LK+ Q
Sbjct: 2258 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2317
Query: 437 GEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEV-KSFMDRKKGFT---EVK 492
++ T+++A+ E LQ+ K E+ E+ ++ +E KE++ + + +GF E +
Sbjct: 2318 AVQEATRLKAEAELLQQQK------ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2371
Query: 493 SQNGEFMT---HKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLE------------ 537
Q M+ +LK SR RA D + + E G++L
Sbjct: 2372 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLHRTELATQEKVTL 2430
Query: 538 ----ELRRRRGETESE-----------EFEKLKQKQQEAALELEELKKKREE-------- 574
E++R++ + ++E E EKL+Q+ + L+ EE++ ++E
Sbjct: 2431 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2490
Query: 575 --------------RRKVLEEEEQRRKQEEAD-----RKLREEEEKRRLKEEIERRR--- 612
R + +E+E+ + +Q D ++LREE+++++ + E ER+R
Sbjct: 2491 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2550
Query: 613 -AEAAEKRQKMPEDGL 627
E A +RQ E+G+
Sbjct: 2551 SMEEARRRQHEAEEGV 2566
Score = 119 bits (297), Expect = 1e-26
Identities = 177/746 (23%), Positives = 308/746 (41%), Gaps = 111/746 (14%)
Query: 9 ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQ--ERLRQKQEE---------E 57
EL K +L A+ A Q D A R+ R A++ ERL+Q+ E E
Sbjct: 1124 ELEATKASLKKLRAQAEAQQPTFD----ALRDELRGAQEVGERLQQRHGERDVEVERWRE 1179
Query: 58 SLGQVTDQVE-VNAQNSVPDEEAKTTTTNTQV---EGDDEAAFLERLARREE-------- 105
+ Q+ ++ + V AQ V E + + D A+L+ RR+E
Sbjct: 1180 RVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLA 1239
Query: 106 ---------RRQKRLQEALERQ-----------KEFDPTITDASLSLPSRRMQNDTAENE 145
R+++ L E +ER K++ I D L L + + Q + +
Sbjct: 1240 DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP 1299
Query: 146 TTEKEEKSESR---QE----RYEIEETETVTKSYQK----------NDWRDAEENKKEDK 188
+ + +S S QE R E T+T Y K + R AE+ + E++
Sbjct: 1300 AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1359
Query: 189 EKEEEEE---EKPKRGSIGENQVEVMVEEKTTESQE--ETVVMSLKNGQISSEEPKQEEE 243
E+ E E EK ++ + Q + E + E Q+ + V+ + + +++ K+ +
Sbjct: 1360 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1419
Query: 244 REQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAA 303
E S +++ + ++ AER+RL EE R+ Q + +R E E +A
Sbjct: 1420 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1479
Query: 304 QERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIK--E 361
E EA++R+ E E+ + + + + + E R+K E + A E+++ ++ E
Sbjct: 1480 ARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALE 1539
Query: 362 EEKRAAEERQR--ARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVN 419
E + AEE +R +AE E +V+ Q + + EK Q
Sbjct: 1540 ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL------- 1592
Query: 420 EKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQED-KPTFKKEEIKDEKIKKDKEPKEEV 478
E+ QE+ + A L+++ E + + QA+ E+ +E+ + ++ ++K + + + EEV
Sbjct: 1593 ERSLQEEHVAVAQLREEAERRAQQ-QAEAERAREEAERELERWQLKANEALRLRLQAEEV 1651
Query: 479 KSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRL-- 536
+ E + + E + E R A + ++ + A +RL
Sbjct: 1652 AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA 1711
Query: 537 -EELRRRRGETESEE------FEKLKQKQQEAAL------ELE-ELKKKREERR-----K 577
+EL R R ETE E E+L + Q+EAA ELE EL K R E K
Sbjct: 1712 EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1771
Query: 578 VLEEEEQRRKQEEADRKLREEEEK-RRLKEEIERRRA---EAAEKRQKMPEDGLSDDKKP 633
EEE R E++ ++L E + R L EE R RA EA +RQ ED +
Sbjct: 1772 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1831
Query: 634 FKCFTPK----GSSLKIEERAEFLNK 655
+ K G + +++ AE K
Sbjct: 1832 ERVLAEKLAAIGEATRLKTEAEIALK 1857
Score = 85.9 bits (211), Expect = 1e-16
Identities = 107/442 (24%), Positives = 204/442 (46%), Gaps = 84/442 (19%)
Query: 1 MDDFERRRELRRQKREEMRLEAERIAYQRNDDDE---------EEAARERRRRARQER-- 49
+++ + ++ L ++ + ++ EA A QR+ +E EE ++ + R + R
Sbjct: 2195 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2254
Query: 50 -LRQK--------QEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERL 100
LR K +E E + QV ++ A+ SV +EA + + + A E++
Sbjct: 2255 ILRDKDNTQRFLQEEAEKMKQVAEEA---ARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2311
Query: 101 ------ARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSE 154
A +E R K E L++QKE +RR+Q D E + E+++
Sbjct: 2312 LKEKMQAVQEATRLKAEAELLQQQKEL--------AQEQARRLQED-KEQMAQQLAEETQ 2362
Query: 155 SRQERYEIEETETVTKS--YQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGE--NQVEV 210
Q E E + S ++ R AE ++ + + +E+ + + + IGE ++ E+
Sbjct: 2363 GFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL 2422
Query: 211 MVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERA 270
+EK T Q + + + + + E+ + I+ E+ E++K + EA+
Sbjct: 2423 ATQEKVTLVQ-----------TLEIQRQQSDHDAERLREAIAELER--EKEKLQQEAKLL 2469
Query: 271 RLEAEERERIKAEQ--------------DKKIADERARIEAEEKAAAQERERREAEERER 316
+L++EE + ++ EQ +K +R R +EKA ++ + E + ++
Sbjct: 2470 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ 2529
Query: 317 MREEEKR----AAEERQRI---KEEEKR---AAEERQRIKEEEKRAAEERQRIKEEEKRA 366
+REE++R +ERQR+ EE +R AEE R K+EE + E+++R ++E+
Sbjct: 2530 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRR--QQEELL 2587
Query: 367 AEERQRARAEEEEKAKVEEQKR 388
AEE QR R E+ +EEQ R
Sbjct: 2588 AEENQRLR---EQLQLLEEQHR 2606
Score = 83.6 bits (205), Expect = 7e-16
Identities = 116/504 (23%), Positives = 218/504 (43%), Gaps = 99/504 (19%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEE---------EAARERRRRARQERLRQKQEE 56
R++ Q+ +RL+ E +Q+N DEE EAAR+R + +E + +
Sbjct: 2179 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ-VEEELFSVRVQM 2237
Query: 57 ESLGQVTDQVEV-----------NAQNSVPDEEAKTTTTNTQVE----GDDEAAFLERLA 101
E L ++ ++E N Q + +E K + EAA L +LA
Sbjct: 2238 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2297
Query: 102 RREERRQKRLQEALERQK-----EFDPTITDASLSLPSRRMQNDTAENETTEKE------ 150
+ +Q+ L E + ++K E +A L + + + A +KE
Sbjct: 2298 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2357
Query: 151 -EKSESRQERYEIEETETVTKSYQKN--DWRDAEENKKEDKEKEEEEEEKPKRGSIGE-- 205
E+++ Q E E + S + R AE ++ + + +E+ + + + IGE
Sbjct: 2358 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2417
Query: 206 NQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERA 265
++ E+ +EK T Q + + + + + E+ + I+ E+ E++K +
Sbjct: 2418 HRTELATQEKVTLVQT-----------LEIQRQQSDHDAERLREAIAELER--EKEKLQQ 2464
Query: 266 EAERARLEAEERERIKAEQ----------------------DKKIADERARIEA---EEK 300
EA+ +L++EE + ++ EQ ++ I E+A++E +E
Sbjct: 2465 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV 2524
Query: 301 AAAQ----ERERREAE-ERERMR-----EEEKRA---AEERQRIKEEEKRAAEERQRIKE 347
A AQ E++R++ + E+ER R EE +R AEE R K+EE + E+++R +
Sbjct: 2525 AKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRR--Q 2582
Query: 348 EEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGE 407
+E+ AEE QR++ E+ + EE+ RA E+ + K L + A+ + E
Sbjct: 2583 QEELLAEENQRLR-EQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAE 2641
Query: 408 KVEQKIEGKWVNEKKAQEDKLQTA 431
E +G +K +LQ A
Sbjct: 2642 P-EHSFDGL---RRKVSAQRLQEA 2661
Score = 75.9 bits (185), Expect = 1e-13
Identities = 104/460 (22%), Positives = 202/460 (43%), Gaps = 57/460 (12%)
Query: 246 QGSDEI--SHHEKMEEEDKERA-----EAERARLEAEERERIKAEQDKKIADERARIEAE 298
QG++E+ +H E+++E A EA +A L ++ R +AE + D + E
Sbjct: 1099 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASL---KKLRAQAEAQQPTFD---ALRDE 1152
Query: 299 EKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQR 358
+ A + ER + ER E E+ Q ++ + A+ R +E E+ + R
Sbjct: 1153 LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY 1212
Query: 359 IKEEEKRAAEERQRARAEEEEKAK--VEEQKRNKQLEEKKHAMQETKIKGEKVE--QKIE 414
+ + A + R +E+ +A + Q +QL +++ ++E + GEKVE Q+
Sbjct: 1213 RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1272
Query: 415 GKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEP 474
+++N K E LQ K Q E + AK+ K+Q
Sbjct: 1273 KQYINAIKDYE--LQLVTYKAQLEPVAS--PAKKPKVQSGS------------------- 1309
Query: 475 KEEVKSFMDRKKGFTE---VKSQNGEFMTHKLKHTENTFSRPGGRASVDTKE--AEGAPQ 529
+ ++ ++D + ++E + SQ +F++ L+ E R + + +E AE
Sbjct: 1310 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE-ERLAEQQRAEERERLAEVEAA 1368
Query: 530 VEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQE 589
+E ++L E + E ++L+Q+ QE + EE +++++ ++EE Q+ +Q
Sbjct: 1369 LEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS 1428
Query: 590 ---EADRKLRE----EEEKRRLKEEIE--RRRAEAAEKRQKMPEDGLSDDKKPFKCFTPK 640
E K R+ E + R++EEI R + EA E+++ E L + + +
Sbjct: 1429 SEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA--RAEEAE 1486
Query: 641 GSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLE 680
+ +E AE L + VQ S K + + S++ + E
Sbjct: 1487 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1526
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 144 bits (363), Expect = 3e-34
Identities = 154/665 (23%), Positives = 306/665 (46%), Gaps = 64/665 (9%)
Query: 15 REEMRLEAERIAYQRND------DDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEV 68
+ E+ LE RI D E EAAR+R+ A +ER R++ EE + + E
Sbjct: 1945 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA 2004
Query: 69 NAQNSVPDEEAKTTTTNTQV------EGDDEAAFLERLARREERRQKRLQE--------A 114
Q EE + + + E+A +LA +E QKRLQ
Sbjct: 2005 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA--QEAAQKRLQAEEKAHAFAV 2062
Query: 115 LERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEE-----KSESRQERYEIEETETVT 169
++++E T+ L R + + A E EE + E+ Q R ++EE E +
Sbjct: 2063 QQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK 2122
Query: 170 KSYQKNDWRDAEENKKEDKEKEEEEEEKPKRG-----SIGENQVEVMVEEKTTESQEETV 224
+S ++ A+ +K ++E E+E +R ++ + Q EK + E+T+
Sbjct: 2123 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2182
Query: 225 VMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQ 284
+ Q + Q EE + + + E+++ E EA R R + EE Q
Sbjct: 2183 RQKAQVEQELTTLRLQLEETDHQKNLLD--EELQRLKAEATEAARQRSQVEEELFSVRVQ 2240
Query: 285 DKKIADERARIEAEEKAA-------AQERERREAEERERMREEEKR---AAEERQRIKE- 333
++++ +ARIEAE +A Q + EAE+ +++ EE R AA+E R+++
Sbjct: 2241 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2300
Query: 334 EEKRAAEER---QRIKEEEKRAAEERQRIKEE------EKRAAEERQRARAEEEEKAKV- 383
E+ A++R +++ +E+ +A +E R+K E +K A+E+ R E++E+
Sbjct: 2301 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ 2360
Query: 384 ---EEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEK 440
E Q + LE ++ E + E+++ ++ + +A+ED + +KQ EE
Sbjct: 2361 LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR---FRKQAEEI 2417
Query: 441 GTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMT 500
G K+ QE + EI+ ++ D E E + ++R+K + +++ + +
Sbjct: 2418 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS 2477
Query: 501 HKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQE 560
+++ + +A + +E ++ + +E+ + + + +E K +Q ++E
Sbjct: 2478 EEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE 2537
Query: 561 AALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAE-AAEKR 619
+ ++++++R+ R V EE RR+Q EA+ +R ++E+ + E+ R++ E AE+
Sbjct: 2538 QQRQQQQMEQERQ--RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEEN 2595
Query: 620 QKMPE 624
Q++ E
Sbjct: 2596 QRLRE 2600
Score = 137 bits (346), Expect = 3e-32
Identities = 171/744 (22%), Positives = 340/744 (45%), Gaps = 106/744 (14%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDD--------------------EEEAARERRRRA 45
R+REL Q+ E+ R AE A QR + EEE AR +R A
Sbjct: 1689 RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA 1748
Query: 46 RQERLRQKQEEESLGQVTDQVEVN-AQNSVPDEEAKTTTTNTQV----------EGDDEA 94
+ RQ+ E E L +V ++EV A + +EE+++T+ ++ E +EA
Sbjct: 1749 AATQKRQELEAE-LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1807
Query: 95 AFLERLARREERRQKRLQEALERQK---------------EFDPTITDASLSLPSRRMQN 139
A L LA +R+++ +E RQ+ E T+A ++L + +N
Sbjct: 1808 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1867
Query: 140 DT----AENETTEKEEKSE-SRQERYEIEETETVTKSYQKNDWRD----AEENKKEDKEK 190
+ AE+E ++ E + Q + +IEE + ++ E+ ++ ++
Sbjct: 1868 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1927
Query: 191 EEEE---EEKPKRGSIGENQVEVMV------EEKTTESQEETVVMSLKNGQISSEEPKQE 241
EEE + ++ + G+ ++E+ + E T S+E+ + + + Q+++EE ++
Sbjct: 1928 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 1987
Query: 242 EEREQ-------GSDEISHHEK--MEEEDKERAEAERARLEAEERERIKAEQDKKIADER 292
E E+ +E + K +EE ++ +A+ E AR E E+ A Q ++A E
Sbjct: 1988 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ-LQLAQEA 2046
Query: 293 A--RIEAEEKAAAQERERREAEERERMREEE------KRAAEERQRIKEEEKRAAEERQR 344
A R++AEEKA A +++E E ++ +++E+ + AE +R EE + A + +R
Sbjct: 2047 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2106
Query: 345 IKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKI 404
+ +R EE +R+K+ + A+ R +A+A E+ K EQ+ ++ + ++ A+++ +
Sbjct: 2107 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2166
Query: 405 KGEKVE--QKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEE 462
++E +K + + +K E +L T L+ Q EE + E+LQ K
Sbjct: 2167 ADAEMEKHKKFAEQTLRQKAQVEQELTT--LRLQLEETDHQKNLLDEELQRLKAE----- 2219
Query: 463 IKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQ-NGEFMTHKLKHTENTFSRPGGRASVDT 521
E ++ + +EE+ S + + +++K++ E L+ +NT A
Sbjct: 2220 -ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2278
Query: 522 KEAEGAPQV----EAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKRE--ER 575
+ AE A ++ + RL +L + EK+ +++ +A E LK + E ++
Sbjct: 2279 QVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2338
Query: 576 RKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFK 635
+K L +E+ RR QE+ +E+ ++L EE + + +RQ+ E ++ +
Sbjct: 2339 QKELAQEQARRLQED------KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR 2392
Query: 636 CFTPKGSSLKIEERAEFLNKSVQK 659
+ + EE A+ K ++
Sbjct: 2393 VAEMSRAQARAEEDAQRFRKQAEE 2416
Score = 129 bits (323), Expect = 1e-29
Identities = 193/835 (23%), Positives = 344/835 (41%), Gaps = 151/835 (18%)
Query: 9 ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRR---------RARQER----LRQKQE 55
E R+ EE RL ++ A +R E EAA E++R +A+ ER L+Q+ +
Sbjct: 1343 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1402
Query: 56 EESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVE-----GDDEAAFLERLARREERRQKR 110
EE + + V+ Q EE + +++ E EAA RL EE R R
Sbjct: 1403 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1462
Query: 111 LQ-EALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIE-----E 164
LQ EA ERQ+ A L + R + + AE + + +E++E + + + E +
Sbjct: 1463 LQLEATERQRG------GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1516
Query: 165 TETVTKSYQKNDWRDAEENKK-----EDKEKEEEEEEKPKRGSIGEN--QVEVMVE---- 213
E S K + A E ++ E+ + EE E+ R + E QV+V +E
Sbjct: 1517 AEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1576
Query: 214 --------------EKTTE-----SQEETVVMSLKNG-------QISSEEPKQEEERE-- 245
EKT + +E V L+ Q +E ++E ERE
Sbjct: 1577 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1636
Query: 246 ---------------------QGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQ 284
Q S + EK +EE + A E R+R AEQ
Sbjct: 1637 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1696
Query: 285 DKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQR 344
+ + + A A+++ AA++ R E E+ ++ + EE R++ E A ++RQ
Sbjct: 1697 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1756
Query: 345 IKEEEKRAAEERQRI------KEEEKRAAEERQRARAEEEE-------------KAKVEE 385
++ E + E + + EEE R+ E+ + R E E +A EE
Sbjct: 1757 LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE 1816
Query: 386 QKRNKQLEEKKHAMQETKIK----------GEKVEQKIEGK-WVNEKKAQEDKLQTAVLK 434
KR +QL E+ A Q + + GE K E + + EK+A+ ++L+
Sbjct: 1817 AKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1876
Query: 435 KQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQ 494
+ + + + QA + K ++ + + D ++++ K E+ + R++ E+ +
Sbjct: 1877 EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED--TLRQRRQVEEEILAL 1934
Query: 495 NGEFMTHKLKHTENTFSRPGGRASV-DTKEAEGAPQVEAGKR----LEELRRRRGETE-- 547
F E R++ DT ++ ++EA ++ EE RRRR E
Sbjct: 1935 KASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV 1994
Query: 548 --SEEFEKLKQKQQEAAL-ELEELKKKREERRKVLEEEEQ------RRKQEEADRKLREE 598
S E+ +Q++AAL E+E LK K EE R++ E EQ + QE A ++L+ E
Sbjct: 1995 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2054
Query: 599 EEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIE----------- 647
E+ + + + + ++++ D L + + + + +++
Sbjct: 2055 EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2114
Query: 648 -ERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASD 701
E AE L +S ++ + ++ QAA K+ EQ + + A + A+D
Sbjct: 2115 VEEAERLKQSAEEQAQARAQAQAA-AEKLRKEAEQEAARRAQAEQAALRQKQAAD 2168
Score = 127 bits (320), Expect = 3e-29
Identities = 187/796 (23%), Positives = 348/796 (43%), Gaps = 194/796 (24%)
Query: 14 KREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNS 73
++ + RLEAE ++ + EEAAR R +R RQ EE++ Q + V A+
Sbjct: 1787 EKSKQRLEAEAGRFR---ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1843
Query: 74 VPDEEAKTTTTNTQV---EGDDEAAFLERLARREERRQKRLQE-ALERQKEFDPTI---- 125
EA T ++ E + E L RLA E +++RL+E A + + + + +
Sbjct: 1844 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1903
Query: 126 --TDASLSLPSRRMQNDTAENETTEKE--------EKSESRQERYEIE------ETETVT 169
+D+ L +++ + E+E EK+ + + E+E E
Sbjct: 1904 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1963
Query: 170 KSYQKNDWRDA--------EENKKEDKEKE-------EEEEEKPKRGSIGE-NQVEVMVE 213
+S ++ + A EE ++ + E+ EEE + ++ ++ E +++ VE
Sbjct: 1964 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 2023
Query: 214 E--KTTESQEETVVMSLKNGQISSEEPKQEEER------EQGSDEISHHEKMEEE--DKE 263
E + E E+ L+ Q ++++ Q EE+ +Q E+ + E+ D+
Sbjct: 2024 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2083
Query: 264 RAEAERARLEAEERERIKAEQDKKIADERARIE--------AEEKA-------AAQERER 308
R EAE AR AEE E + + +++ A R ++E AEE+A AA E+ R
Sbjct: 2084 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2143
Query: 309 REAEERERMREEEKRAAEERQRIKEEE----KRAAEE--RQRIKEEEKRAA--------- 353
+EAE+ R + ++AA +++ + E K+ AE+ RQ+ + E++
Sbjct: 2144 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2203
Query: 354 -------EERQRIKEEEKRAAEERQRARAEEEE-------------KAKVEEQKRNKQLE 393
EE QR+K E AA RQR++ EEE KA++E + R L
Sbjct: 2204 HQKNLLDEELQRLKAEATEAA--RQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2261
Query: 394 EKKHAMQETKIKGEKVEQKIEG---------------KWVNEKKAQEDKLQTAVLKK--Q 436
+K + + + + EK++Q E + E AQ+ L +LK+ Q
Sbjct: 2262 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2321
Query: 437 GEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEV-KSFMDRKKGFT---EVK 492
++ T+++A+ E LQ+ K E+ E+ ++ +E KE++ + + +GF E +
Sbjct: 2322 AVQEATRLKAEAELLQQQK------ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2375
Query: 493 SQNGEFMT---HKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLE------------ 537
Q M+ +LK SR RA D + + E G++L
Sbjct: 2376 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLHRTELATQEKVTL 2434
Query: 538 ----ELRRRRGETESE-----------EFEKLKQKQQEAALELEELKKKREE-------- 574
E++R++ + ++E E EKL+Q+ + L+ EE++ ++E
Sbjct: 2435 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2494
Query: 575 --------------RRKVLEEEEQRRKQEEAD-----RKLREEEEKRRLKEEIERRR--- 612
R + +E+E+ + +Q D ++LREE+++++ + E ER+R
Sbjct: 2495 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2554
Query: 613 -AEAAEKRQKMPEDGL 627
E A +RQ E+G+
Sbjct: 2555 SMEEARRRQHEAEEGV 2570
Score = 119 bits (297), Expect = 1e-26
Identities = 177/746 (23%), Positives = 308/746 (41%), Gaps = 111/746 (14%)
Query: 9 ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQ--ERLRQKQEE---------E 57
EL K +L A+ A Q D A R+ R A++ ERL+Q+ E E
Sbjct: 1128 ELEATKASLKKLRAQAEAQQPTFD----ALRDELRGAQEVGERLQQRHGERDVEVERWRE 1183
Query: 58 SLGQVTDQVE-VNAQNSVPDEEAKTTTTNTQV---EGDDEAAFLERLARREE-------- 105
+ Q+ ++ + V AQ V E + + D A+L+ RR+E
Sbjct: 1184 RVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLA 1243
Query: 106 ---------RRQKRLQEALERQ-----------KEFDPTITDASLSLPSRRMQNDTAENE 145
R+++ L E +ER K++ I D L L + + Q + +
Sbjct: 1244 DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP 1303
Query: 146 TTEKEEKSESR---QE----RYEIEETETVTKSYQK----------NDWRDAEENKKEDK 188
+ + +S S QE R E T+T Y K + R AE+ + E++
Sbjct: 1304 AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1363
Query: 189 EKEEEEE---EKPKRGSIGENQVEVMVEEKTTESQE--ETVVMSLKNGQISSEEPKQEEE 243
E+ E E EK ++ + Q + E + E Q+ + V+ + + +++ K+ +
Sbjct: 1364 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1423
Query: 244 REQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAA 303
E S +++ + ++ AER+RL EE R+ Q + +R E E +A
Sbjct: 1424 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1483
Query: 304 QERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIK--E 361
E EA++R+ E E+ + + + + + E R+K E + A E+++ ++ E
Sbjct: 1484 ARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALE 1543
Query: 362 EEKRAAEERQR--ARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVN 419
E + AEE +R +AE E +V+ Q + + EK Q
Sbjct: 1544 ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL------- 1596
Query: 420 EKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQED-KPTFKKEEIKDEKIKKDKEPKEEV 478
E+ QE+ + A L+++ E + + QA+ E+ +E+ + ++ ++K + + + EEV
Sbjct: 1597 ERSLQEEHVAVAQLREEAERRAQQ-QAEAERAREEAERELERWQLKANEALRLRLQAEEV 1655
Query: 479 KSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRL-- 536
+ E + + E + E R A + ++ + A +RL
Sbjct: 1656 AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA 1715
Query: 537 -EELRRRRGETESEE------FEKLKQKQQEAAL------ELE-ELKKKREERR-----K 577
+EL R R ETE E E+L + Q+EAA ELE EL K R E K
Sbjct: 1716 EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1775
Query: 578 VLEEEEQRRKQEEADRKLREEEEK-RRLKEEIERRRA---EAAEKRQKMPEDGLSDDKKP 633
EEE R E++ ++L E + R L EE R RA EA +RQ ED +
Sbjct: 1776 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1835
Query: 634 FKCFTPK----GSSLKIEERAEFLNK 655
+ K G + +++ AE K
Sbjct: 1836 ERVLAEKLAAIGEATRLKTEAEIALK 1861
Score = 85.9 bits (211), Expect = 1e-16
Identities = 107/442 (24%), Positives = 204/442 (46%), Gaps = 84/442 (19%)
Query: 1 MDDFERRRELRRQKREEMRLEAERIAYQRNDDDE---------EEAARERRRRARQER-- 49
+++ + ++ L ++ + ++ EA A QR+ +E EE ++ + R + R
Sbjct: 2199 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2258
Query: 50 -LRQK--------QEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERL 100
LR K +E E + QV ++ A+ SV +EA + + + A E++
Sbjct: 2259 ILRDKDNTQRFLQEEAEKMKQVAEEA---ARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2315
Query: 101 ------ARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSE 154
A +E R K E L++QKE +RR+Q D E + E+++
Sbjct: 2316 LKEKMQAVQEATRLKAEAELLQQQKEL--------AQEQARRLQED-KEQMAQQLAEETQ 2366
Query: 155 SRQERYEIEETETVTKS--YQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGE--NQVEV 210
Q E E + S ++ R AE ++ + + +E+ + + + IGE ++ E+
Sbjct: 2367 GFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL 2426
Query: 211 MVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERA 270
+EK T Q + + + + + E+ + I+ E+ E++K + EA+
Sbjct: 2427 ATQEKVTLVQ-----------TLEIQRQQSDHDAERLREAIAELER--EKEKLQQEAKLL 2473
Query: 271 RLEAEERERIKAEQ--------------DKKIADERARIEAEEKAAAQERERREAEERER 316
+L++EE + ++ EQ +K +R R +EKA ++ + E + ++
Sbjct: 2474 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ 2533
Query: 317 MREEEKR----AAEERQRI---KEEEKR---AAEERQRIKEEEKRAAEERQRIKEEEKRA 366
+REE++R +ERQR+ EE +R AEE R K+EE + E+++R ++E+
Sbjct: 2534 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRR--QQEELL 2591
Query: 367 AEERQRARAEEEEKAKVEEQKR 388
AEE QR R E+ +EEQ R
Sbjct: 2592 AEENQRLR---EQLQLLEEQHR 2610
Score = 83.6 bits (205), Expect = 7e-16
Identities = 116/504 (23%), Positives = 218/504 (43%), Gaps = 99/504 (19%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEE---------EAARERRRRARQERLRQKQEE 56
R++ Q+ +RL+ E +Q+N DEE EAAR+R + +E + +
Sbjct: 2183 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ-VEEELFSVRVQM 2241
Query: 57 ESLGQVTDQVEV-----------NAQNSVPDEEAKTTTTNTQVE----GDDEAAFLERLA 101
E L ++ ++E N Q + +E K + EAA L +LA
Sbjct: 2242 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2301
Query: 102 RREERRQKRLQEALERQK-----EFDPTITDASLSLPSRRMQNDTAENETTEKE------ 150
+ +Q+ L E + ++K E +A L + + + A +KE
Sbjct: 2302 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2361
Query: 151 -EKSESRQERYEIEETETVTKSYQKN--DWRDAEENKKEDKEKEEEEEEKPKRGSIGE-- 205
E+++ Q E E + S + R AE ++ + + +E+ + + + IGE
Sbjct: 2362 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2421
Query: 206 NQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERA 265
++ E+ +EK T Q + + + + + E+ + I+ E+ E++K +
Sbjct: 2422 HRTELATQEKVTLVQT-----------LEIQRQQSDHDAERLREAIAELER--EKEKLQQ 2468
Query: 266 EAERARLEAEERERIKAEQ----------------------DKKIADERARIEA---EEK 300
EA+ +L++EE + ++ EQ ++ I E+A++E +E
Sbjct: 2469 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV 2528
Query: 301 AAAQ----ERERREAE-ERERMR-----EEEKRA---AEERQRIKEEEKRAAEERQRIKE 347
A AQ E++R++ + E+ER R EE +R AEE R K+EE + E+++R +
Sbjct: 2529 AKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRR--Q 2586
Query: 348 EEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGE 407
+E+ AEE QR++ E+ + EE+ RA E+ + K L + A+ + E
Sbjct: 2587 QEELLAEENQRLR-EQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAE 2645
Query: 408 KVEQKIEGKWVNEKKAQEDKLQTA 431
E +G +K +LQ A
Sbjct: 2646 P-EHSFDGL---RRKVSAQRLQEA 2665
Score = 75.9 bits (185), Expect = 1e-13
Identities = 104/460 (22%), Positives = 202/460 (43%), Gaps = 57/460 (12%)
Query: 246 QGSDEI--SHHEKMEEEDKERA-----EAERARLEAEERERIKAEQDKKIADERARIEAE 298
QG++E+ +H E+++E A EA +A L ++ R +AE + D + E
Sbjct: 1103 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASL---KKLRAQAEAQQPTFD---ALRDE 1156
Query: 299 EKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQR 358
+ A + ER + ER E E+ Q ++ + A+ R +E E+ + R
Sbjct: 1157 LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY 1216
Query: 359 IKEEEKRAAEERQRARAEEEEKAK--VEEQKRNKQLEEKKHAMQETKIKGEKVE--QKIE 414
+ + A + R +E+ +A + Q +QL +++ ++E + GEKVE Q+
Sbjct: 1217 RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1276
Query: 415 GKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEP 474
+++N K E LQ K Q E + AK+ K+Q
Sbjct: 1277 KQYINAIKDYE--LQLVTYKAQLEPVAS--PAKKPKVQSGS------------------- 1313
Query: 475 KEEVKSFMDRKKGFTE---VKSQNGEFMTHKLKHTENTFSRPGGRASVDTKE--AEGAPQ 529
+ ++ ++D + ++E + SQ +F++ L+ E R + + +E AE
Sbjct: 1314 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE-ERLAEQQRAEERERLAEVEAA 1372
Query: 530 VEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQE 589
+E ++L E + E ++L+Q+ QE + EE +++++ ++EE Q+ +Q
Sbjct: 1373 LEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS 1432
Query: 590 ---EADRKLRE----EEEKRRLKEEIE--RRRAEAAEKRQKMPEDGLSDDKKPFKCFTPK 640
E K R+ E + R++EEI R + EA E+++ E L + + +
Sbjct: 1433 SEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA--RAEEAE 1490
Query: 641 GSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLE 680
+ +E AE L + VQ S K + + S++ + E
Sbjct: 1491 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1530
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 144 bits (363), Expect = 3e-34
Identities = 154/665 (23%), Positives = 306/665 (46%), Gaps = 64/665 (9%)
Query: 15 REEMRLEAERIAYQRND------DDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEV 68
+ E+ LE RI D E EAAR+R+ A +ER R++ EE + + E
Sbjct: 1941 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA 2000
Query: 69 NAQNSVPDEEAKTTTTNTQV------EGDDEAAFLERLARREERRQKRLQE--------A 114
Q EE + + + E+A +LA +E QKRLQ
Sbjct: 2001 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA--QEAAQKRLQAEEKAHAFAV 2058
Query: 115 LERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEE-----KSESRQERYEIEETETVT 169
++++E T+ L R + + A E EE + E+ Q R ++EE E +
Sbjct: 2059 QQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK 2118
Query: 170 KSYQKNDWRDAEENKKEDKEKEEEEEEKPKRG-----SIGENQVEVMVEEKTTESQEETV 224
+S ++ A+ +K ++E E+E +R ++ + Q EK + E+T+
Sbjct: 2119 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2178
Query: 225 VMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQ 284
+ Q + Q EE + + + E+++ E EA R R + EE Q
Sbjct: 2179 RQKAQVEQELTTLRLQLEETDHQKNLLD--EELQRLKAEATEAARQRSQVEEELFSVRVQ 2236
Query: 285 DKKIADERARIEAEEKAA-------AQERERREAEERERMREEEKR---AAEERQRIKE- 333
++++ +ARIEAE +A Q + EAE+ +++ EE R AA+E R+++
Sbjct: 2237 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2296
Query: 334 EEKRAAEER---QRIKEEEKRAAEERQRIKEE------EKRAAEERQRARAEEEEKAKV- 383
E+ A++R +++ +E+ +A +E R+K E +K A+E+ R E++E+
Sbjct: 2297 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ 2356
Query: 384 ---EEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEK 440
E Q + LE ++ E + E+++ ++ + +A+ED + +KQ EE
Sbjct: 2357 LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR---FRKQAEEI 2413
Query: 441 GTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMT 500
G K+ QE + EI+ ++ D E E + ++R+K + +++ + +
Sbjct: 2414 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS 2473
Query: 501 HKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQE 560
+++ + +A + +E ++ + +E+ + + + +E K +Q ++E
Sbjct: 2474 EEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE 2533
Query: 561 AALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAE-AAEKR 619
+ ++++++R+ R V EE RR+Q EA+ +R ++E+ + E+ R++ E AE+
Sbjct: 2534 QQRQQQQMEQERQ--RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEEN 2591
Query: 620 QKMPE 624
Q++ E
Sbjct: 2592 QRLRE 2596
Score = 137 bits (346), Expect = 3e-32
Identities = 171/744 (22%), Positives = 340/744 (45%), Gaps = 106/744 (14%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDD--------------------EEEAARERRRRA 45
R+REL Q+ E+ R AE A QR + EEE AR +R A
Sbjct: 1685 RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA 1744
Query: 46 RQERLRQKQEEESLGQVTDQVEVN-AQNSVPDEEAKTTTTNTQV----------EGDDEA 94
+ RQ+ E E L +V ++EV A + +EE+++T+ ++ E +EA
Sbjct: 1745 AATQKRQELEAE-LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1803
Query: 95 AFLERLARREERRQKRLQEALERQK---------------EFDPTITDASLSLPSRRMQN 139
A L LA +R+++ +E RQ+ E T+A ++L + +N
Sbjct: 1804 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1863
Query: 140 DT----AENETTEKEEKSE-SRQERYEIEETETVTKSYQKNDWRD----AEENKKEDKEK 190
+ AE+E ++ E + Q + +IEE + ++ E+ ++ ++
Sbjct: 1864 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1923
Query: 191 EEEE---EEKPKRGSIGENQVEVMV------EEKTTESQEETVVMSLKNGQISSEEPKQE 241
EEE + ++ + G+ ++E+ + E T S+E+ + + + Q+++EE ++
Sbjct: 1924 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 1983
Query: 242 EEREQ-------GSDEISHHEK--MEEEDKERAEAERARLEAEERERIKAEQDKKIADER 292
E E+ +E + K +EE ++ +A+ E AR E E+ A Q ++A E
Sbjct: 1984 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ-LQLAQEA 2042
Query: 293 A--RIEAEEKAAAQERERREAEERERMREEE------KRAAEERQRIKEEEKRAAEERQR 344
A R++AEEKA A +++E E ++ +++E+ + AE +R EE + A + +R
Sbjct: 2043 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2102
Query: 345 IKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKI 404
+ +R EE +R+K+ + A+ R +A+A E+ K EQ+ ++ + ++ A+++ +
Sbjct: 2103 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2162
Query: 405 KGEKVE--QKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEE 462
++E +K + + +K E +L T L+ Q EE + E+LQ K
Sbjct: 2163 ADAEMEKHKKFAEQTLRQKAQVEQELTT--LRLQLEETDHQKNLLDEELQRLKAE----- 2215
Query: 463 IKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQ-NGEFMTHKLKHTENTFSRPGGRASVDT 521
E ++ + +EE+ S + + +++K++ E L+ +NT A
Sbjct: 2216 -ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2274
Query: 522 KEAEGAPQV----EAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKRE--ER 575
+ AE A ++ + RL +L + EK+ +++ +A E LK + E ++
Sbjct: 2275 QVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2334
Query: 576 RKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFK 635
+K L +E+ RR QE+ +E+ ++L EE + + +RQ+ E ++ +
Sbjct: 2335 QKELAQEQARRLQED------KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR 2388
Query: 636 CFTPKGSSLKIEERAEFLNKSVQK 659
+ + EE A+ K ++
Sbjct: 2389 VAEMSRAQARAEEDAQRFRKQAEE 2412
Score = 129 bits (323), Expect = 1e-29
Identities = 193/835 (23%), Positives = 344/835 (41%), Gaps = 151/835 (18%)
Query: 9 ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRR---------RARQER----LRQKQE 55
E R+ EE RL ++ A +R E EAA E++R +A+ ER L+Q+ +
Sbjct: 1339 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1398
Query: 56 EESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVE-----GDDEAAFLERLARREERRQKR 110
EE + + V+ Q EE + +++ E EAA RL EE R R
Sbjct: 1399 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1458
Query: 111 LQ-EALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIE-----E 164
LQ EA ERQ+ A L + R + + AE + + +E++E + + + E +
Sbjct: 1459 LQLEATERQRG------GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1512
Query: 165 TETVTKSYQKNDWRDAEENKK-----EDKEKEEEEEEKPKRGSIGEN--QVEVMVE---- 213
E S K + A E ++ E+ + EE E+ R + E QV+V +E
Sbjct: 1513 AEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1572
Query: 214 --------------EKTTE-----SQEETVVMSLKNG-------QISSEEPKQEEERE-- 245
EKT + +E V L+ Q +E ++E ERE
Sbjct: 1573 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1632
Query: 246 ---------------------QGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQ 284
Q S + EK +EE + A E R+R AEQ
Sbjct: 1633 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1692
Query: 285 DKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQR 344
+ + + A A+++ AA++ R E E+ ++ + EE R++ E A ++RQ
Sbjct: 1693 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1752
Query: 345 IKEEEKRAAEERQRI------KEEEKRAAEERQRARAEEEE-------------KAKVEE 385
++ E + E + + EEE R+ E+ + R E E +A EE
Sbjct: 1753 LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE 1812
Query: 386 QKRNKQLEEKKHAMQETKIK----------GEKVEQKIEGK-WVNEKKAQEDKLQTAVLK 434
KR +QL E+ A Q + + GE K E + + EK+A+ ++L+
Sbjct: 1813 AKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1872
Query: 435 KQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQ 494
+ + + + QA + K ++ + + D ++++ K E+ + R++ E+ +
Sbjct: 1873 EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED--TLRQRRQVEEEILAL 1930
Query: 495 NGEFMTHKLKHTENTFSRPGGRASV-DTKEAEGAPQVEAGKR----LEELRRRRGETE-- 547
F E R++ DT ++ ++EA ++ EE RRRR E
Sbjct: 1931 KASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV 1990
Query: 548 --SEEFEKLKQKQQEAAL-ELEELKKKREERRKVLEEEEQ------RRKQEEADRKLREE 598
S E+ +Q++AAL E+E LK K EE R++ E EQ + QE A ++L+ E
Sbjct: 1991 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2050
Query: 599 EEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIE----------- 647
E+ + + + + ++++ D L + + + + +++
Sbjct: 2051 EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2110
Query: 648 -ERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASD 701
E AE L +S ++ + ++ QAA K+ EQ + + A + A+D
Sbjct: 2111 VEEAERLKQSAEEQAQARAQAQAA-AEKLRKEAEQEAARRAQAEQAALRQKQAAD 2164
Score = 127 bits (320), Expect = 3e-29
Identities = 187/796 (23%), Positives = 348/796 (43%), Gaps = 194/796 (24%)
Query: 14 KREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNS 73
++ + RLEAE ++ + EEAAR R +R RQ EE++ Q + V A+
Sbjct: 1783 EKSKQRLEAEAGRFR---ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1839
Query: 74 VPDEEAKTTTTNTQV---EGDDEAAFLERLARREERRQKRLQE-ALERQKEFDPTI---- 125
EA T ++ E + E L RLA E +++RL+E A + + + + +
Sbjct: 1840 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1899
Query: 126 --TDASLSLPSRRMQNDTAENETTEKE--------EKSESRQERYEIE------ETETVT 169
+D+ L +++ + E+E EK+ + + E+E E
Sbjct: 1900 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1959
Query: 170 KSYQKNDWRDA--------EENKKEDKEKE-------EEEEEKPKRGSIGE-NQVEVMVE 213
+S ++ + A EE ++ + E+ EEE + ++ ++ E +++ VE
Sbjct: 1960 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 2019
Query: 214 E--KTTESQEETVVMSLKNGQISSEEPKQEEER------EQGSDEISHHEKMEEE--DKE 263
E + E E+ L+ Q ++++ Q EE+ +Q E+ + E+ D+
Sbjct: 2020 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2079
Query: 264 RAEAERARLEAEERERIKAEQDKKIADERARIE--------AEEKA-------AAQERER 308
R EAE AR AEE E + + +++ A R ++E AEE+A AA E+ R
Sbjct: 2080 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2139
Query: 309 REAEERERMREEEKRAAEERQRIKEEE----KRAAEE--RQRIKEEEKRAA--------- 353
+EAE+ R + ++AA +++ + E K+ AE+ RQ+ + E++
Sbjct: 2140 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2199
Query: 354 -------EERQRIKEEEKRAAEERQRARAEEEE-------------KAKVEEQKRNKQLE 393
EE QR+K E AA RQR++ EEE KA++E + R L
Sbjct: 2200 HQKNLLDEELQRLKAEATEAA--RQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2257
Query: 394 EKKHAMQETKIKGEKVEQKIEG---------------KWVNEKKAQEDKLQTAVLKK--Q 436
+K + + + + EK++Q E + E AQ+ L +LK+ Q
Sbjct: 2258 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2317
Query: 437 GEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEV-KSFMDRKKGFT---EVK 492
++ T+++A+ E LQ+ K E+ E+ ++ +E KE++ + + +GF E +
Sbjct: 2318 AVQEATRLKAEAELLQQQK------ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2371
Query: 493 SQNGEFMT---HKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLE------------ 537
Q M+ +LK SR RA D + + E G++L
Sbjct: 2372 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLHRTELATQEKVTL 2430
Query: 538 ----ELRRRRGETESE-----------EFEKLKQKQQEAALELEELKKKREE-------- 574
E++R++ + ++E E EKL+Q+ + L+ EE++ ++E
Sbjct: 2431 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2490
Query: 575 --------------RRKVLEEEEQRRKQEEAD-----RKLREEEEKRRLKEEIERRR--- 612
R + +E+E+ + +Q D ++LREE+++++ + E ER+R
Sbjct: 2491 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2550
Query: 613 -AEAAEKRQKMPEDGL 627
E A +RQ E+G+
Sbjct: 2551 SMEEARRRQHEAEEGV 2566
Score = 119 bits (297), Expect = 1e-26
Identities = 177/746 (23%), Positives = 308/746 (41%), Gaps = 111/746 (14%)
Query: 9 ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQ--ERLRQKQEE---------E 57
EL K +L A+ A Q D A R+ R A++ ERL+Q+ E E
Sbjct: 1124 ELEATKASLKKLRAQAEAQQPTFD----ALRDELRGAQEVGERLQQRHGERDVEVERWRE 1179
Query: 58 SLGQVTDQVE-VNAQNSVPDEEAKTTTTNTQV---EGDDEAAFLERLARREE-------- 105
+ Q+ ++ + V AQ V E + + D A+L+ RR+E
Sbjct: 1180 RVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLA 1239
Query: 106 ---------RRQKRLQEALERQ-----------KEFDPTITDASLSLPSRRMQNDTAENE 145
R+++ L E +ER K++ I D L L + + Q + +
Sbjct: 1240 DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP 1299
Query: 146 TTEKEEKSESR---QE----RYEIEETETVTKSYQK----------NDWRDAEENKKEDK 188
+ + +S S QE R E T+T Y K + R AE+ + E++
Sbjct: 1300 AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1359
Query: 189 EKEEEEE---EKPKRGSIGENQVEVMVEEKTTESQE--ETVVMSLKNGQISSEEPKQEEE 243
E+ E E EK ++ + Q + E + E Q+ + V+ + + +++ K+ +
Sbjct: 1360 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1419
Query: 244 REQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAA 303
E S +++ + ++ AER+RL EE R+ Q + +R E E +A
Sbjct: 1420 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1479
Query: 304 QERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIK--E 361
E EA++R+ E E+ + + + + + E R+K E + A E+++ ++ E
Sbjct: 1480 ARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALE 1539
Query: 362 EEKRAAEERQR--ARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVN 419
E + AEE +R +AE E +V+ Q + + EK Q
Sbjct: 1540 ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL------- 1592
Query: 420 EKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQED-KPTFKKEEIKDEKIKKDKEPKEEV 478
E+ QE+ + A L+++ E + + QA+ E+ +E+ + ++ ++K + + + EEV
Sbjct: 1593 ERSLQEEHVAVAQLREEAERRAQQ-QAEAERAREEAERELERWQLKANEALRLRLQAEEV 1651
Query: 479 KSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRL-- 536
+ E + + E + E R A + ++ + A +RL
Sbjct: 1652 AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA 1711
Query: 537 -EELRRRRGETESEE------FEKLKQKQQEAAL------ELE-ELKKKREERR-----K 577
+EL R R ETE E E+L + Q+EAA ELE EL K R E K
Sbjct: 1712 EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1771
Query: 578 VLEEEEQRRKQEEADRKLREEEEK-RRLKEEIERRRA---EAAEKRQKMPEDGLSDDKKP 633
EEE R E++ ++L E + R L EE R RA EA +RQ ED +
Sbjct: 1772 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1831
Query: 634 FKCFTPK----GSSLKIEERAEFLNK 655
+ K G + +++ AE K
Sbjct: 1832 ERVLAEKLAAIGEATRLKTEAEIALK 1857
Score = 85.9 bits (211), Expect = 1e-16
Identities = 107/442 (24%), Positives = 204/442 (46%), Gaps = 84/442 (19%)
Query: 1 MDDFERRRELRRQKREEMRLEAERIAYQRNDDDE---------EEAARERRRRARQER-- 49
+++ + ++ L ++ + ++ EA A QR+ +E EE ++ + R + R
Sbjct: 2195 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2254
Query: 50 -LRQK--------QEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERL 100
LR K +E E + QV ++ A+ SV +EA + + + A E++
Sbjct: 2255 ILRDKDNTQRFLQEEAEKMKQVAEEA---ARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2311
Query: 101 ------ARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSE 154
A +E R K E L++QKE +RR+Q D E + E+++
Sbjct: 2312 LKEKMQAVQEATRLKAEAELLQQQKEL--------AQEQARRLQED-KEQMAQQLAEETQ 2362
Query: 155 SRQERYEIEETETVTKS--YQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGE--NQVEV 210
Q E E + S ++ R AE ++ + + +E+ + + + IGE ++ E+
Sbjct: 2363 GFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL 2422
Query: 211 MVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERA 270
+EK T Q + + + + + E+ + I+ E+ E++K + EA+
Sbjct: 2423 ATQEKVTLVQ-----------TLEIQRQQSDHDAERLREAIAELER--EKEKLQQEAKLL 2469
Query: 271 RLEAEERERIKAEQ--------------DKKIADERARIEAEEKAAAQERERREAEERER 316
+L++EE + ++ EQ +K +R R +EKA ++ + E + ++
Sbjct: 2470 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ 2529
Query: 317 MREEEKR----AAEERQRI---KEEEKR---AAEERQRIKEEEKRAAEERQRIKEEEKRA 366
+REE++R +ERQR+ EE +R AEE R K+EE + E+++R ++E+
Sbjct: 2530 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRR--QQEELL 2587
Query: 367 AEERQRARAEEEEKAKVEEQKR 388
AEE QR R E+ +EEQ R
Sbjct: 2588 AEENQRLR---EQLQLLEEQHR 2606
Score = 83.6 bits (205), Expect = 7e-16
Identities = 116/504 (23%), Positives = 218/504 (43%), Gaps = 99/504 (19%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEE---------EAARERRRRARQERLRQKQEE 56
R++ Q+ +RL+ E +Q+N DEE EAAR+R + +E + +
Sbjct: 2179 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ-VEEELFSVRVQM 2237
Query: 57 ESLGQVTDQVEV-----------NAQNSVPDEEAKTTTTNTQVE----GDDEAAFLERLA 101
E L ++ ++E N Q + +E K + EAA L +LA
Sbjct: 2238 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2297
Query: 102 RREERRQKRLQEALERQK-----EFDPTITDASLSLPSRRMQNDTAENETTEKE------ 150
+ +Q+ L E + ++K E +A L + + + A +KE
Sbjct: 2298 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2357
Query: 151 -EKSESRQERYEIEETETVTKSYQKN--DWRDAEENKKEDKEKEEEEEEKPKRGSIGE-- 205
E+++ Q E E + S + R AE ++ + + +E+ + + + IGE
Sbjct: 2358 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2417
Query: 206 NQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERA 265
++ E+ +EK T Q + + + + + E+ + I+ E+ E++K +
Sbjct: 2418 HRTELATQEKVTLVQT-----------LEIQRQQSDHDAERLREAIAELER--EKEKLQQ 2464
Query: 266 EAERARLEAEERERIKAEQ----------------------DKKIADERARIEA---EEK 300
EA+ +L++EE + ++ EQ ++ I E+A++E +E
Sbjct: 2465 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV 2524
Query: 301 AAAQ----ERERREAE-ERERMR-----EEEKRA---AEERQRIKEEEKRAAEERQRIKE 347
A AQ E++R++ + E+ER R EE +R AEE R K+EE + E+++R +
Sbjct: 2525 AKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRR--Q 2582
Query: 348 EEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGE 407
+E+ AEE QR++ E+ + EE+ RA E+ + K L + A+ + E
Sbjct: 2583 QEELLAEENQRLR-EQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAE 2641
Query: 408 KVEQKIEGKWVNEKKAQEDKLQTA 431
E +G +K +LQ A
Sbjct: 2642 P-EHSFDGL---RRKVSAQRLQEA 2661
Score = 75.9 bits (185), Expect = 1e-13
Identities = 104/460 (22%), Positives = 202/460 (43%), Gaps = 57/460 (12%)
Query: 246 QGSDEI--SHHEKMEEEDKERA-----EAERARLEAEERERIKAEQDKKIADERARIEAE 298
QG++E+ +H E+++E A EA +A L ++ R +AE + D + E
Sbjct: 1099 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASL---KKLRAQAEAQQPTFD---ALRDE 1152
Query: 299 EKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQR 358
+ A + ER + ER E E+ Q ++ + A+ R +E E+ + R
Sbjct: 1153 LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY 1212
Query: 359 IKEEEKRAAEERQRARAEEEEKAK--VEEQKRNKQLEEKKHAMQETKIKGEKVE--QKIE 414
+ + A + R +E+ +A + Q +QL +++ ++E + GEKVE Q+
Sbjct: 1213 RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1272
Query: 415 GKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEP 474
+++N K E LQ K Q E + AK+ K+Q
Sbjct: 1273 KQYINAIKDYE--LQLVTYKAQLEPVAS--PAKKPKVQSGS------------------- 1309
Query: 475 KEEVKSFMDRKKGFTE---VKSQNGEFMTHKLKHTENTFSRPGGRASVDTKE--AEGAPQ 529
+ ++ ++D + ++E + SQ +F++ L+ E R + + +E AE
Sbjct: 1310 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE-ERLAEQQRAEERERLAEVEAA 1368
Query: 530 VEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQE 589
+E ++L E + E ++L+Q+ QE + EE +++++ ++EE Q+ +Q
Sbjct: 1369 LEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS 1428
Query: 590 ---EADRKLRE----EEEKRRLKEEIE--RRRAEAAEKRQKMPEDGLSDDKKPFKCFTPK 640
E K R+ E + R++EEI R + EA E+++ E L + + +
Sbjct: 1429 SEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA--RAEEAE 1486
Query: 641 GSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLE 680
+ +E AE L + VQ S K + + S++ + E
Sbjct: 1487 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1526
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 144 bits (363), Expect = 3e-34
Identities = 154/665 (23%), Positives = 306/665 (46%), Gaps = 64/665 (9%)
Query: 15 REEMRLEAERIAYQRND------DDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEV 68
+ E+ LE RI D E EAAR+R+ A +ER R++ EE + + E
Sbjct: 1909 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA 1968
Query: 69 NAQNSVPDEEAKTTTTNTQV------EGDDEAAFLERLARREERRQKRLQE--------A 114
Q EE + + + E+A +LA +E QKRLQ
Sbjct: 1969 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA--QEAAQKRLQAEEKAHAFAV 2026
Query: 115 LERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEE-----KSESRQERYEIEETETVT 169
++++E T+ L R + + A E EE + E+ Q R ++EE E +
Sbjct: 2027 QQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK 2086
Query: 170 KSYQKNDWRDAEENKKEDKEKEEEEEEKPKRG-----SIGENQVEVMVEEKTTESQEETV 224
+S ++ A+ +K ++E E+E +R ++ + Q EK + E+T+
Sbjct: 2087 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2146
Query: 225 VMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQ 284
+ Q + Q EE + + + E+++ E EA R R + EE Q
Sbjct: 2147 RQKAQVEQELTTLRLQLEETDHQKNLLD--EELQRLKAEATEAARQRSQVEEELFSVRVQ 2204
Query: 285 DKKIADERARIEAEEKAA-------AQERERREAEERERMREEEKR---AAEERQRIKE- 333
++++ +ARIEAE +A Q + EAE+ +++ EE R AA+E R+++
Sbjct: 2205 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2264
Query: 334 EEKRAAEER---QRIKEEEKRAAEERQRIKEE------EKRAAEERQRARAEEEEKAKV- 383
E+ A++R +++ +E+ +A +E R+K E +K A+E+ R E++E+
Sbjct: 2265 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ 2324
Query: 384 ---EEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEK 440
E Q + LE ++ E + E+++ ++ + +A+ED + +KQ EE
Sbjct: 2325 LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR---FRKQAEEI 2381
Query: 441 GTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMT 500
G K+ QE + EI+ ++ D E E + ++R+K + +++ + +
Sbjct: 2382 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS 2441
Query: 501 HKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQE 560
+++ + +A + +E ++ + +E+ + + + +E K +Q ++E
Sbjct: 2442 EEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE 2501
Query: 561 AALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAE-AAEKR 619
+ ++++++R+ R V EE RR+Q EA+ +R ++E+ + E+ R++ E AE+
Sbjct: 2502 QQRQQQQMEQERQ--RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEEN 2559
Query: 620 QKMPE 624
Q++ E
Sbjct: 2560 QRLRE 2564
Score = 137 bits (346), Expect = 3e-32
Identities = 171/744 (22%), Positives = 340/744 (45%), Gaps = 106/744 (14%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDD--------------------EEEAARERRRRA 45
R+REL Q+ E+ R AE A QR + EEE AR +R A
Sbjct: 1653 RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA 1712
Query: 46 RQERLRQKQEEESLGQVTDQVEVN-AQNSVPDEEAKTTTTNTQV----------EGDDEA 94
+ RQ+ E E L +V ++EV A + +EE+++T+ ++ E +EA
Sbjct: 1713 AATQKRQELEAE-LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1771
Query: 95 AFLERLARREERRQKRLQEALERQK---------------EFDPTITDASLSLPSRRMQN 139
A L LA +R+++ +E RQ+ E T+A ++L + +N
Sbjct: 1772 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1831
Query: 140 DT----AENETTEKEEKSE-SRQERYEIEETETVTKSYQKNDWRD----AEENKKEDKEK 190
+ AE+E ++ E + Q + +IEE + ++ E+ ++ ++
Sbjct: 1832 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1891
Query: 191 EEEE---EEKPKRGSIGENQVEVMV------EEKTTESQEETVVMSLKNGQISSEEPKQE 241
EEE + ++ + G+ ++E+ + E T S+E+ + + + Q+++EE ++
Sbjct: 1892 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 1951
Query: 242 EEREQ-------GSDEISHHEK--MEEEDKERAEAERARLEAEERERIKAEQDKKIADER 292
E E+ +E + K +EE ++ +A+ E AR E E+ A Q ++A E
Sbjct: 1952 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ-LQLAQEA 2010
Query: 293 A--RIEAEEKAAAQERERREAEERERMREEE------KRAAEERQRIKEEEKRAAEERQR 344
A R++AEEKA A +++E E ++ +++E+ + AE +R EE + A + +R
Sbjct: 2011 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2070
Query: 345 IKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKI 404
+ +R EE +R+K+ + A+ R +A+A E+ K EQ+ ++ + ++ A+++ +
Sbjct: 2071 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2130
Query: 405 KGEKVE--QKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEE 462
++E +K + + +K E +L T L+ Q EE + E+LQ K
Sbjct: 2131 ADAEMEKHKKFAEQTLRQKAQVEQELTT--LRLQLEETDHQKNLLDEELQRLKAE----- 2183
Query: 463 IKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQ-NGEFMTHKLKHTENTFSRPGGRASVDT 521
E ++ + +EE+ S + + +++K++ E L+ +NT A
Sbjct: 2184 -ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2242
Query: 522 KEAEGAPQV----EAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKRE--ER 575
+ AE A ++ + RL +L + EK+ +++ +A E LK + E ++
Sbjct: 2243 QVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2302
Query: 576 RKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFK 635
+K L +E+ RR QE+ +E+ ++L EE + + +RQ+ E ++ +
Sbjct: 2303 QKELAQEQARRLQED------KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR 2356
Query: 636 CFTPKGSSLKIEERAEFLNKSVQK 659
+ + EE A+ K ++
Sbjct: 2357 VAEMSRAQARAEEDAQRFRKQAEE 2380
Score = 129 bits (323), Expect = 1e-29
Identities = 193/835 (23%), Positives = 344/835 (41%), Gaps = 151/835 (18%)
Query: 9 ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRR---------RARQER----LRQKQE 55
E R+ EE RL ++ A +R E EAA E++R +A+ ER L+Q+ +
Sbjct: 1307 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1366
Query: 56 EESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVE-----GDDEAAFLERLARREERRQKR 110
EE + + V+ Q EE + +++ E EAA RL EE R R
Sbjct: 1367 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1426
Query: 111 LQ-EALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIE-----E 164
LQ EA ERQ+ A L + R + + AE + + +E++E + + + E +
Sbjct: 1427 LQLEATERQRG------GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1480
Query: 165 TETVTKSYQKNDWRDAEENKK-----EDKEKEEEEEEKPKRGSIGEN--QVEVMVE---- 213
E S K + A E ++ E+ + EE E+ R + E QV+V +E
Sbjct: 1481 AEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1540
Query: 214 --------------EKTTE-----SQEETVVMSLKNG-------QISSEEPKQEEERE-- 245
EKT + +E V L+ Q +E ++E ERE
Sbjct: 1541 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1600
Query: 246 ---------------------QGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQ 284
Q S + EK +EE + A E R+R AEQ
Sbjct: 1601 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1660
Query: 285 DKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQR 344
+ + + A A+++ AA++ R E E+ ++ + EE R++ E A ++RQ
Sbjct: 1661 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1720
Query: 345 IKEEEKRAAEERQRI------KEEEKRAAEERQRARAEEEE-------------KAKVEE 385
++ E + E + + EEE R+ E+ + R E E +A EE
Sbjct: 1721 LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE 1780
Query: 386 QKRNKQLEEKKHAMQETKIK----------GEKVEQKIEGK-WVNEKKAQEDKLQTAVLK 434
KR +QL E+ A Q + + GE K E + + EK+A+ ++L+
Sbjct: 1781 AKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1840
Query: 435 KQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQ 494
+ + + + QA + K ++ + + D ++++ K E+ + R++ E+ +
Sbjct: 1841 EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED--TLRQRRQVEEEILAL 1898
Query: 495 NGEFMTHKLKHTENTFSRPGGRASV-DTKEAEGAPQVEAGKR----LEELRRRRGETE-- 547
F E R++ DT ++ ++EA ++ EE RRRR E
Sbjct: 1899 KASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV 1958
Query: 548 --SEEFEKLKQKQQEAAL-ELEELKKKREERRKVLEEEEQ------RRKQEEADRKLREE 598
S E+ +Q++AAL E+E LK K EE R++ E EQ + QE A ++L+ E
Sbjct: 1959 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2018
Query: 599 EEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIE----------- 647
E+ + + + + ++++ D L + + + + +++
Sbjct: 2019 EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2078
Query: 648 -ERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASD 701
E AE L +S ++ + ++ QAA K+ EQ + + A + A+D
Sbjct: 2079 VEEAERLKQSAEEQAQARAQAQAA-AEKLRKEAEQEAARRAQAEQAALRQKQAAD 2132
Score = 127 bits (320), Expect = 3e-29
Identities = 187/796 (23%), Positives = 348/796 (43%), Gaps = 194/796 (24%)
Query: 14 KREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNS 73
++ + RLEAE ++ + EEAAR R +R RQ EE++ Q + V A+
Sbjct: 1751 EKSKQRLEAEAGRFR---ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1807
Query: 74 VPDEEAKTTTTNTQV---EGDDEAAFLERLARREERRQKRLQE-ALERQKEFDPTI---- 125
EA T ++ E + E L RLA E +++RL+E A + + + + +
Sbjct: 1808 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1867
Query: 126 --TDASLSLPSRRMQNDTAENETTEKE--------EKSESRQERYEIE------ETETVT 169
+D+ L +++ + E+E EK+ + + E+E E
Sbjct: 1868 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1927
Query: 170 KSYQKNDWRDA--------EENKKEDKEKE-------EEEEEKPKRGSIGE-NQVEVMVE 213
+S ++ + A EE ++ + E+ EEE + ++ ++ E +++ VE
Sbjct: 1928 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 1987
Query: 214 E--KTTESQEETVVMSLKNGQISSEEPKQEEER------EQGSDEISHHEKMEEE--DKE 263
E + E E+ L+ Q ++++ Q EE+ +Q E+ + E+ D+
Sbjct: 1988 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2047
Query: 264 RAEAERARLEAEERERIKAEQDKKIADERARIE--------AEEKA-------AAQERER 308
R EAE AR AEE E + + +++ A R ++E AEE+A AA E+ R
Sbjct: 2048 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2107
Query: 309 REAEERERMREEEKRAAEERQRIKEEE----KRAAEE--RQRIKEEEKRAA--------- 353
+EAE+ R + ++AA +++ + E K+ AE+ RQ+ + E++
Sbjct: 2108 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2167
Query: 354 -------EERQRIKEEEKRAAEERQRARAEEEE-------------KAKVEEQKRNKQLE 393
EE QR+K E AA RQR++ EEE KA++E + R L
Sbjct: 2168 HQKNLLDEELQRLKAEATEAA--RQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2225
Query: 394 EKKHAMQETKIKGEKVEQKIEG---------------KWVNEKKAQEDKLQTAVLKK--Q 436
+K + + + + EK++Q E + E AQ+ L +LK+ Q
Sbjct: 2226 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2285
Query: 437 GEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEV-KSFMDRKKGFT---EVK 492
++ T+++A+ E LQ+ K E+ E+ ++ +E KE++ + + +GF E +
Sbjct: 2286 AVQEATRLKAEAELLQQQK------ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2339
Query: 493 SQNGEFMT---HKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLE------------ 537
Q M+ +LK SR RA D + + E G++L
Sbjct: 2340 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLHRTELATQEKVTL 2398
Query: 538 ----ELRRRRGETESE-----------EFEKLKQKQQEAALELEELKKKREE-------- 574
E++R++ + ++E E EKL+Q+ + L+ EE++ ++E
Sbjct: 2399 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2458
Query: 575 --------------RRKVLEEEEQRRKQEEAD-----RKLREEEEKRRLKEEIERRR--- 612
R + +E+E+ + +Q D ++LREE+++++ + E ER+R
Sbjct: 2459 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2518
Query: 613 -AEAAEKRQKMPEDGL 627
E A +RQ E+G+
Sbjct: 2519 SMEEARRRQHEAEEGV 2534
Score = 119 bits (297), Expect = 1e-26
Identities = 177/746 (23%), Positives = 308/746 (41%), Gaps = 111/746 (14%)
Query: 9 ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQ--ERLRQKQEE---------E 57
EL K +L A+ A Q D A R+ R A++ ERL+Q+ E E
Sbjct: 1092 ELEATKASLKKLRAQAEAQQPTFD----ALRDELRGAQEVGERLQQRHGERDVEVERWRE 1147
Query: 58 SLGQVTDQVE-VNAQNSVPDEEAKTTTTNTQV---EGDDEAAFLERLARREE-------- 105
+ Q+ ++ + V AQ V E + + D A+L+ RR+E
Sbjct: 1148 RVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLA 1207
Query: 106 ---------RRQKRLQEALERQ-----------KEFDPTITDASLSLPSRRMQNDTAENE 145
R+++ L E +ER K++ I D L L + + Q + +
Sbjct: 1208 DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP 1267
Query: 146 TTEKEEKSESR---QE----RYEIEETETVTKSYQK----------NDWRDAEENKKEDK 188
+ + +S S QE R E T+T Y K + R AE+ + E++
Sbjct: 1268 AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1327
Query: 189 EKEEEEE---EKPKRGSIGENQVEVMVEEKTTESQE--ETVVMSLKNGQISSEEPKQEEE 243
E+ E E EK ++ + Q + E + E Q+ + V+ + + +++ K+ +
Sbjct: 1328 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1387
Query: 244 REQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAA 303
E S +++ + ++ AER+RL EE R+ Q + +R E E +A
Sbjct: 1388 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1447
Query: 304 QERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIK--E 361
E EA++R+ E E+ + + + + + E R+K E + A E+++ ++ E
Sbjct: 1448 ARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALE 1507
Query: 362 EEKRAAEERQR--ARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVN 419
E + AEE +R +AE E +V+ Q + + EK Q
Sbjct: 1508 ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL------- 1560
Query: 420 EKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQED-KPTFKKEEIKDEKIKKDKEPKEEV 478
E+ QE+ + A L+++ E + + QA+ E+ +E+ + ++ ++K + + + EEV
Sbjct: 1561 ERSLQEEHVAVAQLREEAERRAQQ-QAEAERAREEAERELERWQLKANEALRLRLQAEEV 1619
Query: 479 KSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRL-- 536
+ E + + E + E R A + ++ + A +RL
Sbjct: 1620 AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA 1679
Query: 537 -EELRRRRGETESEE------FEKLKQKQQEAAL------ELE-ELKKKREERR-----K 577
+EL R R ETE E E+L + Q+EAA ELE EL K R E K
Sbjct: 1680 EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1739
Query: 578 VLEEEEQRRKQEEADRKLREEEEK-RRLKEEIERRRA---EAAEKRQKMPEDGLSDDKKP 633
EEE R E++ ++L E + R L EE R RA EA +RQ ED +
Sbjct: 1740 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1799
Query: 634 FKCFTPK----GSSLKIEERAEFLNK 655
+ K G + +++ AE K
Sbjct: 1800 ERVLAEKLAAIGEATRLKTEAEIALK 1825
Score = 85.9 bits (211), Expect = 1e-16
Identities = 107/442 (24%), Positives = 204/442 (46%), Gaps = 84/442 (19%)
Query: 1 MDDFERRRELRRQKREEMRLEAERIAYQRNDDDE---------EEAARERRRRARQER-- 49
+++ + ++ L ++ + ++ EA A QR+ +E EE ++ + R + R
Sbjct: 2163 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2222
Query: 50 -LRQK--------QEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERL 100
LR K +E E + QV ++ A+ SV +EA + + + A E++
Sbjct: 2223 ILRDKDNTQRFLQEEAEKMKQVAEEA---ARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2279
Query: 101 ------ARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSE 154
A +E R K E L++QKE +RR+Q D E + E+++
Sbjct: 2280 LKEKMQAVQEATRLKAEAELLQQQKEL--------AQEQARRLQED-KEQMAQQLAEETQ 2330
Query: 155 SRQERYEIEETETVTKS--YQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGE--NQVEV 210
Q E E + S ++ R AE ++ + + +E+ + + + IGE ++ E+
Sbjct: 2331 GFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL 2390
Query: 211 MVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERA 270
+EK T Q + + + + + E+ + I+ E+ E++K + EA+
Sbjct: 2391 ATQEKVTLVQ-----------TLEIQRQQSDHDAERLREAIAELER--EKEKLQQEAKLL 2437
Query: 271 RLEAEERERIKAEQ--------------DKKIADERARIEAEEKAAAQERERREAEERER 316
+L++EE + ++ EQ +K +R R +EKA ++ + E + ++
Sbjct: 2438 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ 2497
Query: 317 MREEEKR----AAEERQRI---KEEEKR---AAEERQRIKEEEKRAAEERQRIKEEEKRA 366
+REE++R +ERQR+ EE +R AEE R K+EE + E+++R ++E+
Sbjct: 2498 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRR--QQEELL 2555
Query: 367 AEERQRARAEEEEKAKVEEQKR 388
AEE QR R E+ +EEQ R
Sbjct: 2556 AEENQRLR---EQLQLLEEQHR 2574
Score = 83.6 bits (205), Expect = 7e-16
Identities = 116/504 (23%), Positives = 218/504 (43%), Gaps = 99/504 (19%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEE---------EAARERRRRARQERLRQKQEE 56
R++ Q+ +RL+ E +Q+N DEE EAAR+R + +E + +
Sbjct: 2147 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ-VEEELFSVRVQM 2205
Query: 57 ESLGQVTDQVEV-----------NAQNSVPDEEAKTTTTNTQVE----GDDEAAFLERLA 101
E L ++ ++E N Q + +E K + EAA L +LA
Sbjct: 2206 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2265
Query: 102 RREERRQKRLQEALERQK-----EFDPTITDASLSLPSRRMQNDTAENETTEKE------ 150
+ +Q+ L E + ++K E +A L + + + A +KE
Sbjct: 2266 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2325
Query: 151 -EKSESRQERYEIEETETVTKSYQKN--DWRDAEENKKEDKEKEEEEEEKPKRGSIGE-- 205
E+++ Q E E + S + R AE ++ + + +E+ + + + IGE
Sbjct: 2326 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2385
Query: 206 NQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERA 265
++ E+ +EK T Q + + + + + E+ + I+ E+ E++K +
Sbjct: 2386 HRTELATQEKVTLVQT-----------LEIQRQQSDHDAERLREAIAELER--EKEKLQQ 2432
Query: 266 EAERARLEAEERERIKAEQ----------------------DKKIADERARIEA---EEK 300
EA+ +L++EE + ++ EQ ++ I E+A++E +E
Sbjct: 2433 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV 2492
Query: 301 AAAQ----ERERREAE-ERERMR-----EEEKRA---AEERQRIKEEEKRAAEERQRIKE 347
A AQ E++R++ + E+ER R EE +R AEE R K+EE + E+++R +
Sbjct: 2493 AKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRR--Q 2550
Query: 348 EEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGE 407
+E+ AEE QR++ E+ + EE+ RA E+ + K L + A+ + E
Sbjct: 2551 QEELLAEENQRLR-EQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAE 2609
Query: 408 KVEQKIEGKWVNEKKAQEDKLQTA 431
E +G +K +LQ A
Sbjct: 2610 P-EHSFDGL---RRKVSAQRLQEA 2629
Score = 75.9 bits (185), Expect = 1e-13
Identities = 104/460 (22%), Positives = 202/460 (43%), Gaps = 57/460 (12%)
Query: 246 QGSDEI--SHHEKMEEEDKERA-----EAERARLEAEERERIKAEQDKKIADERARIEAE 298
QG++E+ +H E+++E A EA +A L ++ R +AE + D + E
Sbjct: 1067 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASL---KKLRAQAEAQQPTFD---ALRDE 1120
Query: 299 EKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQR 358
+ A + ER + ER E E+ Q ++ + A+ R +E E+ + R
Sbjct: 1121 LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY 1180
Query: 359 IKEEEKRAAEERQRARAEEEEKAK--VEEQKRNKQLEEKKHAMQETKIKGEKVE--QKIE 414
+ + A + R +E+ +A + Q +QL +++ ++E + GEKVE Q+
Sbjct: 1181 RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1240
Query: 415 GKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEP 474
+++N K E LQ K Q E + AK+ K+Q
Sbjct: 1241 KQYINAIKDYE--LQLVTYKAQLEPVAS--PAKKPKVQSGS------------------- 1277
Query: 475 KEEVKSFMDRKKGFTE---VKSQNGEFMTHKLKHTENTFSRPGGRASVDTKE--AEGAPQ 529
+ ++ ++D + ++E + SQ +F++ L+ E R + + +E AE
Sbjct: 1278 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE-ERLAEQQRAEERERLAEVEAA 1336
Query: 530 VEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQE 589
+E ++L E + E ++L+Q+ QE + EE +++++ ++EE Q+ +Q
Sbjct: 1337 LEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS 1396
Query: 590 ---EADRKLRE----EEEKRRLKEEIE--RRRAEAAEKRQKMPEDGLSDDKKPFKCFTPK 640
E K R+ E + R++EEI R + EA E+++ E L + + +
Sbjct: 1397 SEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA--RAEEAE 1454
Query: 641 GSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLE 680
+ +E AE L + VQ S K + + S++ + E
Sbjct: 1455 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1494
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 144 bits (363), Expect = 3e-34
Identities = 154/665 (23%), Positives = 306/665 (46%), Gaps = 64/665 (9%)
Query: 15 REEMRLEAERIAYQRND------DDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEV 68
+ E+ LE RI D E EAAR+R+ A +ER R++ EE + + E
Sbjct: 2078 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA 2137
Query: 69 NAQNSVPDEEAKTTTTNTQV------EGDDEAAFLERLARREERRQKRLQE--------A 114
Q EE + + + E+A +LA +E QKRLQ
Sbjct: 2138 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA--QEAAQKRLQAEEKAHAFAV 2195
Query: 115 LERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEE-----KSESRQERYEIEETETVT 169
++++E T+ L R + + A E EE + E+ Q R ++EE E +
Sbjct: 2196 QQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK 2255
Query: 170 KSYQKNDWRDAEENKKEDKEKEEEEEEKPKRG-----SIGENQVEVMVEEKTTESQEETV 224
+S ++ A+ +K ++E E+E +R ++ + Q EK + E+T+
Sbjct: 2256 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2315
Query: 225 VMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQ 284
+ Q + Q EE + + + E+++ E EA R R + EE Q
Sbjct: 2316 RQKAQVEQELTTLRLQLEETDHQKNLLD--EELQRLKAEATEAARQRSQVEEELFSVRVQ 2373
Query: 285 DKKIADERARIEAEEKAA-------AQERERREAEERERMREEEKR---AAEERQRIKE- 333
++++ +ARIEAE +A Q + EAE+ +++ EE R AA+E R+++
Sbjct: 2374 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2433
Query: 334 EEKRAAEER---QRIKEEEKRAAEERQRIKEE------EKRAAEERQRARAEEEEKAKV- 383
E+ A++R +++ +E+ +A +E R+K E +K A+E+ R E++E+
Sbjct: 2434 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ 2493
Query: 384 ---EEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEK 440
E Q + LE ++ E + E+++ ++ + +A+ED + +KQ EE
Sbjct: 2494 LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR---FRKQAEEI 2550
Query: 441 GTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMT 500
G K+ QE + EI+ ++ D E E + ++R+K + +++ + +
Sbjct: 2551 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS 2610
Query: 501 HKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQE 560
+++ + +A + +E ++ + +E+ + + + +E K +Q ++E
Sbjct: 2611 EEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE 2670
Query: 561 AALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAE-AAEKR 619
+ ++++++R+ R V EE RR+Q EA+ +R ++E+ + E+ R++ E AE+
Sbjct: 2671 QQRQQQQMEQERQ--RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEEN 2728
Query: 620 QKMPE 624
Q++ E
Sbjct: 2729 QRLRE 2733
Score = 137 bits (346), Expect = 3e-32
Identities = 171/744 (22%), Positives = 340/744 (45%), Gaps = 106/744 (14%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDD--------------------EEEAARERRRRA 45
R+REL Q+ E+ R AE A QR + EEE AR +R A
Sbjct: 1822 RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA 1881
Query: 46 RQERLRQKQEEESLGQVTDQVEVN-AQNSVPDEEAKTTTTNTQV----------EGDDEA 94
+ RQ+ E E L +V ++EV A + +EE+++T+ ++ E +EA
Sbjct: 1882 AATQKRQELEAE-LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1940
Query: 95 AFLERLARREERRQKRLQEALERQK---------------EFDPTITDASLSLPSRRMQN 139
A L LA +R+++ +E RQ+ E T+A ++L + +N
Sbjct: 1941 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 2000
Query: 140 DT----AENETTEKEEKSE-SRQERYEIEETETVTKSYQKNDWRD----AEENKKEDKEK 190
+ AE+E ++ E + Q + +IEE + ++ E+ ++ ++
Sbjct: 2001 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 2060
Query: 191 EEEE---EEKPKRGSIGENQVEVMV------EEKTTESQEETVVMSLKNGQISSEEPKQE 241
EEE + ++ + G+ ++E+ + E T S+E+ + + + Q+++EE ++
Sbjct: 2061 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 2120
Query: 242 EEREQ-------GSDEISHHEK--MEEEDKERAEAERARLEAEERERIKAEQDKKIADER 292
E E+ +E + K +EE ++ +A+ E AR E E+ A Q ++A E
Sbjct: 2121 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ-LQLAQEA 2179
Query: 293 A--RIEAEEKAAAQERERREAEERERMREEE------KRAAEERQRIKEEEKRAAEERQR 344
A R++AEEKA A +++E E ++ +++E+ + AE +R EE + A + +R
Sbjct: 2180 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2239
Query: 345 IKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKI 404
+ +R EE +R+K+ + A+ R +A+A E+ K EQ+ ++ + ++ A+++ +
Sbjct: 2240 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2299
Query: 405 KGEKVE--QKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEE 462
++E +K + + +K E +L T L+ Q EE + E+LQ K
Sbjct: 2300 ADAEMEKHKKFAEQTLRQKAQVEQELTT--LRLQLEETDHQKNLLDEELQRLKAE----- 2352
Query: 463 IKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQ-NGEFMTHKLKHTENTFSRPGGRASVDT 521
E ++ + +EE+ S + + +++K++ E L+ +NT A
Sbjct: 2353 -ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2411
Query: 522 KEAEGAPQV----EAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKRE--ER 575
+ AE A ++ + RL +L + EK+ +++ +A E LK + E ++
Sbjct: 2412 QVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2471
Query: 576 RKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFK 635
+K L +E+ RR QE+ +E+ ++L EE + + +RQ+ E ++ +
Sbjct: 2472 QKELAQEQARRLQED------KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR 2525
Query: 636 CFTPKGSSLKIEERAEFLNKSVQK 659
+ + EE A+ K ++
Sbjct: 2526 VAEMSRAQARAEEDAQRFRKQAEE 2549
Score = 129 bits (323), Expect = 1e-29
Identities = 193/835 (23%), Positives = 344/835 (41%), Gaps = 151/835 (18%)
Query: 9 ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRR---------RARQER----LRQKQE 55
E R+ EE RL ++ A +R E EAA E++R +A+ ER L+Q+ +
Sbjct: 1476 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1535
Query: 56 EESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVE-----GDDEAAFLERLARREERRQKR 110
EE + + V+ Q EE + +++ E EAA RL EE R R
Sbjct: 1536 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1595
Query: 111 LQ-EALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIE-----E 164
LQ EA ERQ+ A L + R + + AE + + +E++E + + + E +
Sbjct: 1596 LQLEATERQRG------GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1649
Query: 165 TETVTKSYQKNDWRDAEENKK-----EDKEKEEEEEEKPKRGSIGEN--QVEVMVE---- 213
E S K + A E ++ E+ + EE E+ R + E QV+V +E
Sbjct: 1650 AEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1709
Query: 214 --------------EKTTE-----SQEETVVMSLKNG-------QISSEEPKQEEERE-- 245
EKT + +E V L+ Q +E ++E ERE
Sbjct: 1710 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1769
Query: 246 ---------------------QGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQ 284
Q S + EK +EE + A E R+R AEQ
Sbjct: 1770 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1829
Query: 285 DKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQR 344
+ + + A A+++ AA++ R E E+ ++ + EE R++ E A ++RQ
Sbjct: 1830 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1889
Query: 345 IKEEEKRAAEERQRI------KEEEKRAAEERQRARAEEEE-------------KAKVEE 385
++ E + E + + EEE R+ E+ + R E E +A EE
Sbjct: 1890 LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE 1949
Query: 386 QKRNKQLEEKKHAMQETKIK----------GEKVEQKIEGK-WVNEKKAQEDKLQTAVLK 434
KR +QL E+ A Q + + GE K E + + EK+A+ ++L+
Sbjct: 1950 AKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 2009
Query: 435 KQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQ 494
+ + + + QA + K ++ + + D ++++ K E+ + R++ E+ +
Sbjct: 2010 EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED--TLRQRRQVEEEILAL 2067
Query: 495 NGEFMTHKLKHTENTFSRPGGRASV-DTKEAEGAPQVEAGKR----LEELRRRRGETE-- 547
F E R++ DT ++ ++EA ++ EE RRRR E
Sbjct: 2068 KASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV 2127
Query: 548 --SEEFEKLKQKQQEAAL-ELEELKKKREERRKVLEEEEQ------RRKQEEADRKLREE 598
S E+ +Q++AAL E+E LK K EE R++ E EQ + QE A ++L+ E
Sbjct: 2128 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2187
Query: 599 EEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIE----------- 647
E+ + + + + ++++ D L + + + + +++
Sbjct: 2188 EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2247
Query: 648 -ERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASD 701
E AE L +S ++ + ++ QAA K+ EQ + + A + A+D
Sbjct: 2248 VEEAERLKQSAEEQAQARAQAQAA-AEKLRKEAEQEAARRAQAEQAALRQKQAAD 2301
Score = 127 bits (320), Expect = 3e-29
Identities = 187/796 (23%), Positives = 348/796 (43%), Gaps = 194/796 (24%)
Query: 14 KREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNS 73
++ + RLEAE ++ + EEAAR R +R RQ EE++ Q + V A+
Sbjct: 1920 EKSKQRLEAEAGRFR---ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1976
Query: 74 VPDEEAKTTTTNTQV---EGDDEAAFLERLARREERRQKRLQE-ALERQKEFDPTI---- 125
EA T ++ E + E L RLA E +++RL+E A + + + + +
Sbjct: 1977 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 2036
Query: 126 --TDASLSLPSRRMQNDTAENETTEKE--------EKSESRQERYEIE------ETETVT 169
+D+ L +++ + E+E EK+ + + E+E E
Sbjct: 2037 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 2096
Query: 170 KSYQKNDWRDA--------EENKKEDKEKE-------EEEEEKPKRGSIGE-NQVEVMVE 213
+S ++ + A EE ++ + E+ EEE + ++ ++ E +++ VE
Sbjct: 2097 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 2156
Query: 214 E--KTTESQEETVVMSLKNGQISSEEPKQEEER------EQGSDEISHHEKMEEE--DKE 263
E + E E+ L+ Q ++++ Q EE+ +Q E+ + E+ D+
Sbjct: 2157 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2216
Query: 264 RAEAERARLEAEERERIKAEQDKKIADERARIE--------AEEKA-------AAQERER 308
R EAE AR AEE E + + +++ A R ++E AEE+A AA E+ R
Sbjct: 2217 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2276
Query: 309 REAEERERMREEEKRAAEERQRIKEEE----KRAAEE--RQRIKEEEKRAA--------- 353
+EAE+ R + ++AA +++ + E K+ AE+ RQ+ + E++
Sbjct: 2277 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2336
Query: 354 -------EERQRIKEEEKRAAEERQRARAEEEE-------------KAKVEEQKRNKQLE 393
EE QR+K E AA RQR++ EEE KA++E + R L
Sbjct: 2337 HQKNLLDEELQRLKAEATEAA--RQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2394
Query: 394 EKKHAMQETKIKGEKVEQKIEG---------------KWVNEKKAQEDKLQTAVLKK--Q 436
+K + + + + EK++Q E + E AQ+ L +LK+ Q
Sbjct: 2395 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2454
Query: 437 GEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEV-KSFMDRKKGFT---EVK 492
++ T+++A+ E LQ+ K E+ E+ ++ +E KE++ + + +GF E +
Sbjct: 2455 AVQEATRLKAEAELLQQQK------ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2508
Query: 493 SQNGEFMT---HKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLE------------ 537
Q M+ +LK SR RA D + + E G++L
Sbjct: 2509 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLHRTELATQEKVTL 2567
Query: 538 ----ELRRRRGETESE-----------EFEKLKQKQQEAALELEELKKKREE-------- 574
E++R++ + ++E E EKL+Q+ + L+ EE++ ++E
Sbjct: 2568 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2627
Query: 575 --------------RRKVLEEEEQRRKQEEAD-----RKLREEEEKRRLKEEIERRR--- 612
R + +E+E+ + +Q D ++LREE+++++ + E ER+R
Sbjct: 2628 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2687
Query: 613 -AEAAEKRQKMPEDGL 627
E A +RQ E+G+
Sbjct: 2688 SMEEARRRQHEAEEGV 2703
Score = 119 bits (297), Expect = 1e-26
Identities = 177/746 (23%), Positives = 308/746 (41%), Gaps = 111/746 (14%)
Query: 9 ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQ--ERLRQKQEE---------E 57
EL K +L A+ A Q D A R+ R A++ ERL+Q+ E E
Sbjct: 1261 ELEATKASLKKLRAQAEAQQPTFD----ALRDELRGAQEVGERLQQRHGERDVEVERWRE 1316
Query: 58 SLGQVTDQVE-VNAQNSVPDEEAKTTTTNTQV---EGDDEAAFLERLARREE-------- 105
+ Q+ ++ + V AQ V E + + D A+L+ RR+E
Sbjct: 1317 RVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLA 1376
Query: 106 ---------RRQKRLQEALERQ-----------KEFDPTITDASLSLPSRRMQNDTAENE 145
R+++ L E +ER K++ I D L L + + Q + +
Sbjct: 1377 DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP 1436
Query: 146 TTEKEEKSESR---QE----RYEIEETETVTKSYQK----------NDWRDAEENKKEDK 188
+ + +S S QE R E T+T Y K + R AE+ + E++
Sbjct: 1437 AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1496
Query: 189 EKEEEEE---EKPKRGSIGENQVEVMVEEKTTESQE--ETVVMSLKNGQISSEEPKQEEE 243
E+ E E EK ++ + Q + E + E Q+ + V+ + + +++ K+ +
Sbjct: 1497 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1556
Query: 244 REQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAA 303
E S +++ + ++ AER+RL EE R+ Q + +R E E +A
Sbjct: 1557 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1616
Query: 304 QERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIK--E 361
E EA++R+ E E+ + + + + + E R+K E + A E+++ ++ E
Sbjct: 1617 ARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALE 1676
Query: 362 EEKRAAEERQR--ARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVN 419
E + AEE +R +AE E +V+ Q + + EK Q
Sbjct: 1677 ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL------- 1729
Query: 420 EKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQED-KPTFKKEEIKDEKIKKDKEPKEEV 478
E+ QE+ + A L+++ E + + QA+ E+ +E+ + ++ ++K + + + EEV
Sbjct: 1730 ERSLQEEHVAVAQLREEAERRAQQ-QAEAERAREEAERELERWQLKANEALRLRLQAEEV 1788
Query: 479 KSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRL-- 536
+ E + + E + E R A + ++ + A +RL
Sbjct: 1789 AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA 1848
Query: 537 -EELRRRRGETESEE------FEKLKQKQQEAAL------ELE-ELKKKREERR-----K 577
+EL R R ETE E E+L + Q+EAA ELE EL K R E K
Sbjct: 1849 EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1908
Query: 578 VLEEEEQRRKQEEADRKLREEEEK-RRLKEEIERRRA---EAAEKRQKMPEDGLSDDKKP 633
EEE R E++ ++L E + R L EE R RA EA +RQ ED +
Sbjct: 1909 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1968
Query: 634 FKCFTPK----GSSLKIEERAEFLNK 655
+ K G + +++ AE K
Sbjct: 1969 ERVLAEKLAAIGEATRLKTEAEIALK 1994
Score = 85.9 bits (211), Expect = 1e-16
Identities = 107/442 (24%), Positives = 204/442 (46%), Gaps = 84/442 (19%)
Query: 1 MDDFERRRELRRQKREEMRLEAERIAYQRNDDDE---------EEAARERRRRARQER-- 49
+++ + ++ L ++ + ++ EA A QR+ +E EE ++ + R + R
Sbjct: 2332 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2391
Query: 50 -LRQK--------QEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERL 100
LR K +E E + QV ++ A+ SV +EA + + + A E++
Sbjct: 2392 ILRDKDNTQRFLQEEAEKMKQVAEEA---ARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2448
Query: 101 ------ARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSE 154
A +E R K E L++QKE +RR+Q D E + E+++
Sbjct: 2449 LKEKMQAVQEATRLKAEAELLQQQKEL--------AQEQARRLQED-KEQMAQQLAEETQ 2499
Query: 155 SRQERYEIEETETVTKS--YQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGE--NQVEV 210
Q E E + S ++ R AE ++ + + +E+ + + + IGE ++ E+
Sbjct: 2500 GFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL 2559
Query: 211 MVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERA 270
+EK T Q + + + + + E+ + I+ E+ E++K + EA+
Sbjct: 2560 ATQEKVTLVQ-----------TLEIQRQQSDHDAERLREAIAELER--EKEKLQQEAKLL 2606
Query: 271 RLEAEERERIKAEQ--------------DKKIADERARIEAEEKAAAQERERREAEERER 316
+L++EE + ++ EQ +K +R R +EKA ++ + E + ++
Sbjct: 2607 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ 2666
Query: 317 MREEEKR----AAEERQRI---KEEEKR---AAEERQRIKEEEKRAAEERQRIKEEEKRA 366
+REE++R +ERQR+ EE +R AEE R K+EE + E+++R ++E+
Sbjct: 2667 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRR--QQEELL 2724
Query: 367 AEERQRARAEEEEKAKVEEQKR 388
AEE QR R E+ +EEQ R
Sbjct: 2725 AEENQRLR---EQLQLLEEQHR 2743
Score = 83.6 bits (205), Expect = 7e-16
Identities = 116/504 (23%), Positives = 218/504 (43%), Gaps = 99/504 (19%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEE---------EAARERRRRARQERLRQKQEE 56
R++ Q+ +RL+ E +Q+N DEE EAAR+R + +E + +
Sbjct: 2316 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ-VEEELFSVRVQM 2374
Query: 57 ESLGQVTDQVEV-----------NAQNSVPDEEAKTTTTNTQVE----GDDEAAFLERLA 101
E L ++ ++E N Q + +E K + EAA L +LA
Sbjct: 2375 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2434
Query: 102 RREERRQKRLQEALERQK-----EFDPTITDASLSLPSRRMQNDTAENETTEKE------ 150
+ +Q+ L E + ++K E +A L + + + A +KE
Sbjct: 2435 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2494
Query: 151 -EKSESRQERYEIEETETVTKSYQKN--DWRDAEENKKEDKEKEEEEEEKPKRGSIGE-- 205
E+++ Q E E + S + R AE ++ + + +E+ + + + IGE
Sbjct: 2495 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2554
Query: 206 NQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERA 265
++ E+ +EK T Q + + + + + E+ + I+ E+ E++K +
Sbjct: 2555 HRTELATQEKVTLVQT-----------LEIQRQQSDHDAERLREAIAELER--EKEKLQQ 2601
Query: 266 EAERARLEAEERERIKAEQ----------------------DKKIADERARIEA---EEK 300
EA+ +L++EE + ++ EQ ++ I E+A++E +E
Sbjct: 2602 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV 2661
Query: 301 AAAQ----ERERREAE-ERERMR-----EEEKRA---AEERQRIKEEEKRAAEERQRIKE 347
A AQ E++R++ + E+ER R EE +R AEE R K+EE + E+++R +
Sbjct: 2662 AKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRR--Q 2719
Query: 348 EEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGE 407
+E+ AEE QR++ E+ + EE+ RA E+ + K L + A+ + E
Sbjct: 2720 QEELLAEENQRLR-EQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAE 2778
Query: 408 KVEQKIEGKWVNEKKAQEDKLQTA 431
E +G +K +LQ A
Sbjct: 2779 P-EHSFDGL---RRKVSAQRLQEA 2798
Score = 75.9 bits (185), Expect = 1e-13
Identities = 104/460 (22%), Positives = 202/460 (43%), Gaps = 57/460 (12%)
Query: 246 QGSDEI--SHHEKMEEEDKERA-----EAERARLEAEERERIKAEQDKKIADERARIEAE 298
QG++E+ +H E+++E A EA +A L ++ R +AE + D + E
Sbjct: 1236 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASL---KKLRAQAEAQQPTFD---ALRDE 1289
Query: 299 EKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQR 358
+ A + ER + ER E E+ Q ++ + A+ R +E E+ + R
Sbjct: 1290 LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY 1349
Query: 359 IKEEEKRAAEERQRARAEEEEKAK--VEEQKRNKQLEEKKHAMQETKIKGEKVE--QKIE 414
+ + A + R +E+ +A + Q +QL +++ ++E + GEKVE Q+
Sbjct: 1350 RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1409
Query: 415 GKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEP 474
+++N K E LQ K Q E + AK+ K+Q
Sbjct: 1410 KQYINAIKDYE--LQLVTYKAQLEPVAS--PAKKPKVQSGS------------------- 1446
Query: 475 KEEVKSFMDRKKGFTE---VKSQNGEFMTHKLKHTENTFSRPGGRASVDTKE--AEGAPQ 529
+ ++ ++D + ++E + SQ +F++ L+ E R + + +E AE
Sbjct: 1447 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE-ERLAEQQRAEERERLAEVEAA 1505
Query: 530 VEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQE 589
+E ++L E + E ++L+Q+ QE + EE +++++ ++EE Q+ +Q
Sbjct: 1506 LEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS 1565
Query: 590 ---EADRKLRE----EEEKRRLKEEIE--RRRAEAAEKRQKMPEDGLSDDKKPFKCFTPK 640
E K R+ E + R++EEI R + EA E+++ E L + + +
Sbjct: 1566 SEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA--RAEEAE 1623
Query: 641 GSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLE 680
+ +E AE L + VQ S K + + S++ + E
Sbjct: 1624 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1663
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 144 bits (363), Expect = 3e-34
Identities = 154/665 (23%), Positives = 306/665 (46%), Gaps = 64/665 (9%)
Query: 15 REEMRLEAERIAYQRND------DDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEV 68
+ E+ LE RI D E EAAR+R+ A +ER R++ EE + + E
Sbjct: 1919 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA 1978
Query: 69 NAQNSVPDEEAKTTTTNTQV------EGDDEAAFLERLARREERRQKRLQE--------A 114
Q EE + + + E+A +LA +E QKRLQ
Sbjct: 1979 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA--QEAAQKRLQAEEKAHAFAV 2036
Query: 115 LERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEE-----KSESRQERYEIEETETVT 169
++++E T+ L R + + A E EE + E+ Q R ++EE E +
Sbjct: 2037 QQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK 2096
Query: 170 KSYQKNDWRDAEENKKEDKEKEEEEEEKPKRG-----SIGENQVEVMVEEKTTESQEETV 224
+S ++ A+ +K ++E E+E +R ++ + Q EK + E+T+
Sbjct: 2097 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2156
Query: 225 VMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQ 284
+ Q + Q EE + + + E+++ E EA R R + EE Q
Sbjct: 2157 RQKAQVEQELTTLRLQLEETDHQKNLLD--EELQRLKAEATEAARQRSQVEEELFSVRVQ 2214
Query: 285 DKKIADERARIEAEEKAA-------AQERERREAEERERMREEEKR---AAEERQRIKE- 333
++++ +ARIEAE +A Q + EAE+ +++ EE R AA+E R+++
Sbjct: 2215 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2274
Query: 334 EEKRAAEER---QRIKEEEKRAAEERQRIKEE------EKRAAEERQRARAEEEEKAKV- 383
E+ A++R +++ +E+ +A +E R+K E +K A+E+ R E++E+
Sbjct: 2275 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ 2334
Query: 384 ---EEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEK 440
E Q + LE ++ E + E+++ ++ + +A+ED + +KQ EE
Sbjct: 2335 LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR---FRKQAEEI 2391
Query: 441 GTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMT 500
G K+ QE + EI+ ++ D E E + ++R+K + +++ + +
Sbjct: 2392 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS 2451
Query: 501 HKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQE 560
+++ + +A + +E ++ + +E+ + + + +E K +Q ++E
Sbjct: 2452 EEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE 2511
Query: 561 AALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAE-AAEKR 619
+ ++++++R+ R V EE RR+Q EA+ +R ++E+ + E+ R++ E AE+
Sbjct: 2512 QQRQQQQMEQERQ--RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEEN 2569
Query: 620 QKMPE 624
Q++ E
Sbjct: 2570 QRLRE 2574
Score = 137 bits (346), Expect = 3e-32
Identities = 171/744 (22%), Positives = 340/744 (45%), Gaps = 106/744 (14%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDD--------------------EEEAARERRRRA 45
R+REL Q+ E+ R AE A QR + EEE AR +R A
Sbjct: 1663 RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA 1722
Query: 46 RQERLRQKQEEESLGQVTDQVEVN-AQNSVPDEEAKTTTTNTQV----------EGDDEA 94
+ RQ+ E E L +V ++EV A + +EE+++T+ ++ E +EA
Sbjct: 1723 AATQKRQELEAE-LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1781
Query: 95 AFLERLARREERRQKRLQEALERQK---------------EFDPTITDASLSLPSRRMQN 139
A L LA +R+++ +E RQ+ E T+A ++L + +N
Sbjct: 1782 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1841
Query: 140 DT----AENETTEKEEKSE-SRQERYEIEETETVTKSYQKNDWRD----AEENKKEDKEK 190
+ AE+E ++ E + Q + +IEE + ++ E+ ++ ++
Sbjct: 1842 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1901
Query: 191 EEEE---EEKPKRGSIGENQVEVMV------EEKTTESQEETVVMSLKNGQISSEEPKQE 241
EEE + ++ + G+ ++E+ + E T S+E+ + + + Q+++EE ++
Sbjct: 1902 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 1961
Query: 242 EEREQ-------GSDEISHHEK--MEEEDKERAEAERARLEAEERERIKAEQDKKIADER 292
E E+ +E + K +EE ++ +A+ E AR E E+ A Q ++A E
Sbjct: 1962 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ-LQLAQEA 2020
Query: 293 A--RIEAEEKAAAQERERREAEERERMREEE------KRAAEERQRIKEEEKRAAEERQR 344
A R++AEEKA A +++E E ++ +++E+ + AE +R EE + A + +R
Sbjct: 2021 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2080
Query: 345 IKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKI 404
+ +R EE +R+K+ + A+ R +A+A E+ K EQ+ ++ + ++ A+++ +
Sbjct: 2081 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2140
Query: 405 KGEKVE--QKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEE 462
++E +K + + +K E +L T L+ Q EE + E+LQ K
Sbjct: 2141 ADAEMEKHKKFAEQTLRQKAQVEQELTT--LRLQLEETDHQKNLLDEELQRLKAE----- 2193
Query: 463 IKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQ-NGEFMTHKLKHTENTFSRPGGRASVDT 521
E ++ + +EE+ S + + +++K++ E L+ +NT A
Sbjct: 2194 -ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2252
Query: 522 KEAEGAPQV----EAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKRE--ER 575
+ AE A ++ + RL +L + EK+ +++ +A E LK + E ++
Sbjct: 2253 QVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2312
Query: 576 RKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFK 635
+K L +E+ RR QE+ +E+ ++L EE + + +RQ+ E ++ +
Sbjct: 2313 QKELAQEQARRLQED------KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR 2366
Query: 636 CFTPKGSSLKIEERAEFLNKSVQK 659
+ + EE A+ K ++
Sbjct: 2367 VAEMSRAQARAEEDAQRFRKQAEE 2390
Score = 129 bits (323), Expect = 1e-29
Identities = 193/835 (23%), Positives = 344/835 (41%), Gaps = 151/835 (18%)
Query: 9 ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRR---------RARQER----LRQKQE 55
E R+ EE RL ++ A +R E EAA E++R +A+ ER L+Q+ +
Sbjct: 1317 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1376
Query: 56 EESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVE-----GDDEAAFLERLARREERRQKR 110
EE + + V+ Q EE + +++ E EAA RL EE R R
Sbjct: 1377 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1436
Query: 111 LQ-EALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIE-----E 164
LQ EA ERQ+ A L + R + + AE + + +E++E + + + E +
Sbjct: 1437 LQLEATERQRG------GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1490
Query: 165 TETVTKSYQKNDWRDAEENKK-----EDKEKEEEEEEKPKRGSIGEN--QVEVMVE---- 213
E S K + A E ++ E+ + EE E+ R + E QV+V +E
Sbjct: 1491 AEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1550
Query: 214 --------------EKTTE-----SQEETVVMSLKNG-------QISSEEPKQEEERE-- 245
EKT + +E V L+ Q +E ++E ERE
Sbjct: 1551 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1610
Query: 246 ---------------------QGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQ 284
Q S + EK +EE + A E R+R AEQ
Sbjct: 1611 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1670
Query: 285 DKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQR 344
+ + + A A+++ AA++ R E E+ ++ + EE R++ E A ++RQ
Sbjct: 1671 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1730
Query: 345 IKEEEKRAAEERQRI------KEEEKRAAEERQRARAEEEE-------------KAKVEE 385
++ E + E + + EEE R+ E+ + R E E +A EE
Sbjct: 1731 LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE 1790
Query: 386 QKRNKQLEEKKHAMQETKIK----------GEKVEQKIEGK-WVNEKKAQEDKLQTAVLK 434
KR +QL E+ A Q + + GE K E + + EK+A+ ++L+
Sbjct: 1791 AKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1850
Query: 435 KQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQ 494
+ + + + QA + K ++ + + D ++++ K E+ + R++ E+ +
Sbjct: 1851 EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED--TLRQRRQVEEEILAL 1908
Query: 495 NGEFMTHKLKHTENTFSRPGGRASV-DTKEAEGAPQVEAGKR----LEELRRRRGETE-- 547
F E R++ DT ++ ++EA ++ EE RRRR E
Sbjct: 1909 KASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV 1968
Query: 548 --SEEFEKLKQKQQEAAL-ELEELKKKREERRKVLEEEEQ------RRKQEEADRKLREE 598
S E+ +Q++AAL E+E LK K EE R++ E EQ + QE A ++L+ E
Sbjct: 1969 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2028
Query: 599 EEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIE----------- 647
E+ + + + + ++++ D L + + + + +++
Sbjct: 2029 EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2088
Query: 648 -ERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASD 701
E AE L +S ++ + ++ QAA K+ EQ + + A + A+D
Sbjct: 2089 VEEAERLKQSAEEQAQARAQAQAA-AEKLRKEAEQEAARRAQAEQAALRQKQAAD 2142
Score = 127 bits (320), Expect = 3e-29
Identities = 187/796 (23%), Positives = 348/796 (43%), Gaps = 194/796 (24%)
Query: 14 KREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNS 73
++ + RLEAE ++ + EEAAR R +R RQ EE++ Q + V A+
Sbjct: 1761 EKSKQRLEAEAGRFR---ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1817
Query: 74 VPDEEAKTTTTNTQV---EGDDEAAFLERLARREERRQKRLQE-ALERQKEFDPTI---- 125
EA T ++ E + E L RLA E +++RL+E A + + + + +
Sbjct: 1818 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1877
Query: 126 --TDASLSLPSRRMQNDTAENETTEKE--------EKSESRQERYEIE------ETETVT 169
+D+ L +++ + E+E EK+ + + E+E E
Sbjct: 1878 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1937
Query: 170 KSYQKNDWRDA--------EENKKEDKEKE-------EEEEEKPKRGSIGE-NQVEVMVE 213
+S ++ + A EE ++ + E+ EEE + ++ ++ E +++ VE
Sbjct: 1938 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 1997
Query: 214 E--KTTESQEETVVMSLKNGQISSEEPKQEEER------EQGSDEISHHEKMEEE--DKE 263
E + E E+ L+ Q ++++ Q EE+ +Q E+ + E+ D+
Sbjct: 1998 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2057
Query: 264 RAEAERARLEAEERERIKAEQDKKIADERARIE--------AEEKA-------AAQERER 308
R EAE AR AEE E + + +++ A R ++E AEE+A AA E+ R
Sbjct: 2058 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2117
Query: 309 REAEERERMREEEKRAAEERQRIKEEE----KRAAEE--RQRIKEEEKRAA--------- 353
+EAE+ R + ++AA +++ + E K+ AE+ RQ+ + E++
Sbjct: 2118 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2177
Query: 354 -------EERQRIKEEEKRAAEERQRARAEEEE-------------KAKVEEQKRNKQLE 393
EE QR+K E AA RQR++ EEE KA++E + R L
Sbjct: 2178 HQKNLLDEELQRLKAEATEAA--RQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2235
Query: 394 EKKHAMQETKIKGEKVEQKIEG---------------KWVNEKKAQEDKLQTAVLKK--Q 436
+K + + + + EK++Q E + E AQ+ L +LK+ Q
Sbjct: 2236 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2295
Query: 437 GEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEV-KSFMDRKKGFT---EVK 492
++ T+++A+ E LQ+ K E+ E+ ++ +E KE++ + + +GF E +
Sbjct: 2296 AVQEATRLKAEAELLQQQK------ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2349
Query: 493 SQNGEFMT---HKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLE------------ 537
Q M+ +LK SR RA D + + E G++L
Sbjct: 2350 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLHRTELATQEKVTL 2408
Query: 538 ----ELRRRRGETESE-----------EFEKLKQKQQEAALELEELKKKREE-------- 574
E++R++ + ++E E EKL+Q+ + L+ EE++ ++E
Sbjct: 2409 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2468
Query: 575 --------------RRKVLEEEEQRRKQEEAD-----RKLREEEEKRRLKEEIERRR--- 612
R + +E+E+ + +Q D ++LREE+++++ + E ER+R
Sbjct: 2469 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2528
Query: 613 -AEAAEKRQKMPEDGL 627
E A +RQ E+G+
Sbjct: 2529 SMEEARRRQHEAEEGV 2544
Score = 119 bits (297), Expect = 1e-26
Identities = 177/746 (23%), Positives = 308/746 (41%), Gaps = 111/746 (14%)
Query: 9 ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQ--ERLRQKQEE---------E 57
EL K +L A+ A Q D A R+ R A++ ERL+Q+ E E
Sbjct: 1102 ELEATKASLKKLRAQAEAQQPTFD----ALRDELRGAQEVGERLQQRHGERDVEVERWRE 1157
Query: 58 SLGQVTDQVE-VNAQNSVPDEEAKTTTTNTQV---EGDDEAAFLERLARREE-------- 105
+ Q+ ++ + V AQ V E + + D A+L+ RR+E
Sbjct: 1158 RVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLA 1217
Query: 106 ---------RRQKRLQEALERQ-----------KEFDPTITDASLSLPSRRMQNDTAENE 145
R+++ L E +ER K++ I D L L + + Q + +
Sbjct: 1218 DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP 1277
Query: 146 TTEKEEKSESR---QE----RYEIEETETVTKSYQK----------NDWRDAEENKKEDK 188
+ + +S S QE R E T+T Y K + R AE+ + E++
Sbjct: 1278 AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1337
Query: 189 EKEEEEE---EKPKRGSIGENQVEVMVEEKTTESQE--ETVVMSLKNGQISSEEPKQEEE 243
E+ E E EK ++ + Q + E + E Q+ + V+ + + +++ K+ +
Sbjct: 1338 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1397
Query: 244 REQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAA 303
E S +++ + ++ AER+RL EE R+ Q + +R E E +A
Sbjct: 1398 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1457
Query: 304 QERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIK--E 361
E EA++R+ E E+ + + + + + E R+K E + A E+++ ++ E
Sbjct: 1458 ARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALE 1517
Query: 362 EEKRAAEERQR--ARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVN 419
E + AEE +R +AE E +V+ Q + + EK Q
Sbjct: 1518 ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL------- 1570
Query: 420 EKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQED-KPTFKKEEIKDEKIKKDKEPKEEV 478
E+ QE+ + A L+++ E + + QA+ E+ +E+ + ++ ++K + + + EEV
Sbjct: 1571 ERSLQEEHVAVAQLREEAERRAQQ-QAEAERAREEAERELERWQLKANEALRLRLQAEEV 1629
Query: 479 KSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRL-- 536
+ E + + E + E R A + ++ + A +RL
Sbjct: 1630 AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA 1689
Query: 537 -EELRRRRGETESEE------FEKLKQKQQEAAL------ELE-ELKKKREERR-----K 577
+EL R R ETE E E+L + Q+EAA ELE EL K R E K
Sbjct: 1690 EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1749
Query: 578 VLEEEEQRRKQEEADRKLREEEEK-RRLKEEIERRRA---EAAEKRQKMPEDGLSDDKKP 633
EEE R E++ ++L E + R L EE R RA EA +RQ ED +
Sbjct: 1750 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1809
Query: 634 FKCFTPK----GSSLKIEERAEFLNK 655
+ K G + +++ AE K
Sbjct: 1810 ERVLAEKLAAIGEATRLKTEAEIALK 1835
Score = 85.9 bits (211), Expect = 1e-16
Identities = 107/442 (24%), Positives = 204/442 (46%), Gaps = 84/442 (19%)
Query: 1 MDDFERRRELRRQKREEMRLEAERIAYQRNDDDE---------EEAARERRRRARQER-- 49
+++ + ++ L ++ + ++ EA A QR+ +E EE ++ + R + R
Sbjct: 2173 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2232
Query: 50 -LRQK--------QEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERL 100
LR K +E E + QV ++ A+ SV +EA + + + A E++
Sbjct: 2233 ILRDKDNTQRFLQEEAEKMKQVAEEA---ARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2289
Query: 101 ------ARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSE 154
A +E R K E L++QKE +RR+Q D E + E+++
Sbjct: 2290 LKEKMQAVQEATRLKAEAELLQQQKEL--------AQEQARRLQED-KEQMAQQLAEETQ 2340
Query: 155 SRQERYEIEETETVTKS--YQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGE--NQVEV 210
Q E E + S ++ R AE ++ + + +E+ + + + IGE ++ E+
Sbjct: 2341 GFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL 2400
Query: 211 MVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERA 270
+EK T Q + + + + + E+ + I+ E+ E++K + EA+
Sbjct: 2401 ATQEKVTLVQ-----------TLEIQRQQSDHDAERLREAIAELER--EKEKLQQEAKLL 2447
Query: 271 RLEAEERERIKAEQ--------------DKKIADERARIEAEEKAAAQERERREAEERER 316
+L++EE + ++ EQ +K +R R +EKA ++ + E + ++
Sbjct: 2448 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ 2507
Query: 317 MREEEKR----AAEERQRI---KEEEKR---AAEERQRIKEEEKRAAEERQRIKEEEKRA 366
+REE++R +ERQR+ EE +R AEE R K+EE + E+++R ++E+
Sbjct: 2508 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRR--QQEELL 2565
Query: 367 AEERQRARAEEEEKAKVEEQKR 388
AEE QR R E+ +EEQ R
Sbjct: 2566 AEENQRLR---EQLQLLEEQHR 2584
Score = 83.6 bits (205), Expect = 7e-16
Identities = 116/504 (23%), Positives = 218/504 (43%), Gaps = 99/504 (19%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEE---------EAARERRRRARQERLRQKQEE 56
R++ Q+ +RL+ E +Q+N DEE EAAR+R + +E + +
Sbjct: 2157 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ-VEEELFSVRVQM 2215
Query: 57 ESLGQVTDQVEV-----------NAQNSVPDEEAKTTTTNTQVE----GDDEAAFLERLA 101
E L ++ ++E N Q + +E K + EAA L +LA
Sbjct: 2216 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2275
Query: 102 RREERRQKRLQEALERQK-----EFDPTITDASLSLPSRRMQNDTAENETTEKE------ 150
+ +Q+ L E + ++K E +A L + + + A +KE
Sbjct: 2276 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2335
Query: 151 -EKSESRQERYEIEETETVTKSYQKN--DWRDAEENKKEDKEKEEEEEEKPKRGSIGE-- 205
E+++ Q E E + S + R AE ++ + + +E+ + + + IGE
Sbjct: 2336 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2395
Query: 206 NQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERA 265
++ E+ +EK T Q + + + + + E+ + I+ E+ E++K +
Sbjct: 2396 HRTELATQEKVTLVQT-----------LEIQRQQSDHDAERLREAIAELER--EKEKLQQ 2442
Query: 266 EAERARLEAEERERIKAEQ----------------------DKKIADERARIEA---EEK 300
EA+ +L++EE + ++ EQ ++ I E+A++E +E
Sbjct: 2443 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV 2502
Query: 301 AAAQ----ERERREAE-ERERMR-----EEEKRA---AEERQRIKEEEKRAAEERQRIKE 347
A AQ E++R++ + E+ER R EE +R AEE R K+EE + E+++R +
Sbjct: 2503 AKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRR--Q 2560
Query: 348 EEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGE 407
+E+ AEE QR++ E+ + EE+ RA E+ + K L + A+ + E
Sbjct: 2561 QEELLAEENQRLR-EQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAE 2619
Query: 408 KVEQKIEGKWVNEKKAQEDKLQTA 431
E +G +K +LQ A
Sbjct: 2620 P-EHSFDGL---RRKVSAQRLQEA 2639
Score = 75.9 bits (185), Expect = 1e-13
Identities = 104/460 (22%), Positives = 202/460 (43%), Gaps = 57/460 (12%)
Query: 246 QGSDEI--SHHEKMEEEDKERA-----EAERARLEAEERERIKAEQDKKIADERARIEAE 298
QG++E+ +H E+++E A EA +A L ++ R +AE + D + E
Sbjct: 1077 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASL---KKLRAQAEAQQPTFD---ALRDE 1130
Query: 299 EKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQR 358
+ A + ER + ER E E+ Q ++ + A+ R +E E+ + R
Sbjct: 1131 LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY 1190
Query: 359 IKEEEKRAAEERQRARAEEEEKAK--VEEQKRNKQLEEKKHAMQETKIKGEKVE--QKIE 414
+ + A + R +E+ +A + Q +QL +++ ++E + GEKVE Q+
Sbjct: 1191 RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1250
Query: 415 GKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEP 474
+++N K E LQ K Q E + AK+ K+Q
Sbjct: 1251 KQYINAIKDYE--LQLVTYKAQLEPVAS--PAKKPKVQSGS------------------- 1287
Query: 475 KEEVKSFMDRKKGFTE---VKSQNGEFMTHKLKHTENTFSRPGGRASVDTKE--AEGAPQ 529
+ ++ ++D + ++E + SQ +F++ L+ E R + + +E AE
Sbjct: 1288 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE-ERLAEQQRAEERERLAEVEAA 1346
Query: 530 VEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQE 589
+E ++L E + E ++L+Q+ QE + EE +++++ ++EE Q+ +Q
Sbjct: 1347 LEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS 1406
Query: 590 ---EADRKLRE----EEEKRRLKEEIE--RRRAEAAEKRQKMPEDGLSDDKKPFKCFTPK 640
E K R+ E + R++EEI R + EA E+++ E L + + +
Sbjct: 1407 SEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA--RAEEAE 1464
Query: 641 GSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLE 680
+ +E AE L + VQ S K + + S++ + E
Sbjct: 1465 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1504
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 144 bits (363), Expect = 3e-34
Identities = 154/665 (23%), Positives = 306/665 (46%), Gaps = 64/665 (9%)
Query: 15 REEMRLEAERIAYQRND------DDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEV 68
+ E+ LE RI D E EAAR+R+ A +ER R++ EE + + E
Sbjct: 1927 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA 1986
Query: 69 NAQNSVPDEEAKTTTTNTQV------EGDDEAAFLERLARREERRQKRLQE--------A 114
Q EE + + + E+A +LA +E QKRLQ
Sbjct: 1987 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA--QEAAQKRLQAEEKAHAFAV 2044
Query: 115 LERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEE-----KSESRQERYEIEETETVT 169
++++E T+ L R + + A E EE + E+ Q R ++EE E +
Sbjct: 2045 QQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK 2104
Query: 170 KSYQKNDWRDAEENKKEDKEKEEEEEEKPKRG-----SIGENQVEVMVEEKTTESQEETV 224
+S ++ A+ +K ++E E+E +R ++ + Q EK + E+T+
Sbjct: 2105 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2164
Query: 225 VMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQ 284
+ Q + Q EE + + + E+++ E EA R R + EE Q
Sbjct: 2165 RQKAQVEQELTTLRLQLEETDHQKNLLD--EELQRLKAEATEAARQRSQVEEELFSVRVQ 2222
Query: 285 DKKIADERARIEAEEKAA-------AQERERREAEERERMREEEKR---AAEERQRIKE- 333
++++ +ARIEAE +A Q + EAE+ +++ EE R AA+E R+++
Sbjct: 2223 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2282
Query: 334 EEKRAAEER---QRIKEEEKRAAEERQRIKEE------EKRAAEERQRARAEEEEKAKV- 383
E+ A++R +++ +E+ +A +E R+K E +K A+E+ R E++E+
Sbjct: 2283 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ 2342
Query: 384 ---EEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEK 440
E Q + LE ++ E + E+++ ++ + +A+ED + +KQ EE
Sbjct: 2343 LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR---FRKQAEEI 2399
Query: 441 GTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMT 500
G K+ QE + EI+ ++ D E E + ++R+K + +++ + +
Sbjct: 2400 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS 2459
Query: 501 HKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQE 560
+++ + +A + +E ++ + +E+ + + + +E K +Q ++E
Sbjct: 2460 EEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE 2519
Query: 561 AALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAE-AAEKR 619
+ ++++++R+ R V EE RR+Q EA+ +R ++E+ + E+ R++ E AE+
Sbjct: 2520 QQRQQQQMEQERQ--RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEEN 2577
Query: 620 QKMPE 624
Q++ E
Sbjct: 2578 QRLRE 2582
Score = 137 bits (346), Expect = 3e-32
Identities = 171/744 (22%), Positives = 340/744 (45%), Gaps = 106/744 (14%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDD--------------------EEEAARERRRRA 45
R+REL Q+ E+ R AE A QR + EEE AR +R A
Sbjct: 1671 RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA 1730
Query: 46 RQERLRQKQEEESLGQVTDQVEVN-AQNSVPDEEAKTTTTNTQV----------EGDDEA 94
+ RQ+ E E L +V ++EV A + +EE+++T+ ++ E +EA
Sbjct: 1731 AATQKRQELEAE-LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1789
Query: 95 AFLERLARREERRQKRLQEALERQK---------------EFDPTITDASLSLPSRRMQN 139
A L LA +R+++ +E RQ+ E T+A ++L + +N
Sbjct: 1790 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1849
Query: 140 DT----AENETTEKEEKSE-SRQERYEIEETETVTKSYQKNDWRD----AEENKKEDKEK 190
+ AE+E ++ E + Q + +IEE + ++ E+ ++ ++
Sbjct: 1850 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1909
Query: 191 EEEE---EEKPKRGSIGENQVEVMV------EEKTTESQEETVVMSLKNGQISSEEPKQE 241
EEE + ++ + G+ ++E+ + E T S+E+ + + + Q+++EE ++
Sbjct: 1910 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 1969
Query: 242 EEREQ-------GSDEISHHEK--MEEEDKERAEAERARLEAEERERIKAEQDKKIADER 292
E E+ +E + K +EE ++ +A+ E AR E E+ A Q ++A E
Sbjct: 1970 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ-LQLAQEA 2028
Query: 293 A--RIEAEEKAAAQERERREAEERERMREEE------KRAAEERQRIKEEEKRAAEERQR 344
A R++AEEKA A +++E E ++ +++E+ + AE +R EE + A + +R
Sbjct: 2029 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2088
Query: 345 IKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKI 404
+ +R EE +R+K+ + A+ R +A+A E+ K EQ+ ++ + ++ A+++ +
Sbjct: 2089 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2148
Query: 405 KGEKVE--QKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEE 462
++E +K + + +K E +L T L+ Q EE + E+LQ K
Sbjct: 2149 ADAEMEKHKKFAEQTLRQKAQVEQELTT--LRLQLEETDHQKNLLDEELQRLKAE----- 2201
Query: 463 IKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQ-NGEFMTHKLKHTENTFSRPGGRASVDT 521
E ++ + +EE+ S + + +++K++ E L+ +NT A
Sbjct: 2202 -ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2260
Query: 522 KEAEGAPQV----EAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKRE--ER 575
+ AE A ++ + RL +L + EK+ +++ +A E LK + E ++
Sbjct: 2261 QVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2320
Query: 576 RKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFK 635
+K L +E+ RR QE+ +E+ ++L EE + + +RQ+ E ++ +
Sbjct: 2321 QKELAQEQARRLQED------KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR 2374
Query: 636 CFTPKGSSLKIEERAEFLNKSVQK 659
+ + EE A+ K ++
Sbjct: 2375 VAEMSRAQARAEEDAQRFRKQAEE 2398
Score = 129 bits (323), Expect = 1e-29
Identities = 193/835 (23%), Positives = 344/835 (41%), Gaps = 151/835 (18%)
Query: 9 ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRR---------RARQER----LRQKQE 55
E R+ EE RL ++ A +R E EAA E++R +A+ ER L+Q+ +
Sbjct: 1325 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1384
Query: 56 EESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVE-----GDDEAAFLERLARREERRQKR 110
EE + + V+ Q EE + +++ E EAA RL EE R R
Sbjct: 1385 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1444
Query: 111 LQ-EALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIE-----E 164
LQ EA ERQ+ A L + R + + AE + + +E++E + + + E +
Sbjct: 1445 LQLEATERQRG------GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1498
Query: 165 TETVTKSYQKNDWRDAEENKK-----EDKEKEEEEEEKPKRGSIGEN--QVEVMVE---- 213
E S K + A E ++ E+ + EE E+ R + E QV+V +E
Sbjct: 1499 AEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1558
Query: 214 --------------EKTTE-----SQEETVVMSLKNG-------QISSEEPKQEEERE-- 245
EKT + +E V L+ Q +E ++E ERE
Sbjct: 1559 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1618
Query: 246 ---------------------QGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQ 284
Q S + EK +EE + A E R+R AEQ
Sbjct: 1619 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1678
Query: 285 DKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQR 344
+ + + A A+++ AA++ R E E+ ++ + EE R++ E A ++RQ
Sbjct: 1679 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1738
Query: 345 IKEEEKRAAEERQRI------KEEEKRAAEERQRARAEEEE-------------KAKVEE 385
++ E + E + + EEE R+ E+ + R E E +A EE
Sbjct: 1739 LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE 1798
Query: 386 QKRNKQLEEKKHAMQETKIK----------GEKVEQKIEGK-WVNEKKAQEDKLQTAVLK 434
KR +QL E+ A Q + + GE K E + + EK+A+ ++L+
Sbjct: 1799 AKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1858
Query: 435 KQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQ 494
+ + + + QA + K ++ + + D ++++ K E+ + R++ E+ +
Sbjct: 1859 EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED--TLRQRRQVEEEILAL 1916
Query: 495 NGEFMTHKLKHTENTFSRPGGRASV-DTKEAEGAPQVEAGKR----LEELRRRRGETE-- 547
F E R++ DT ++ ++EA ++ EE RRRR E
Sbjct: 1917 KASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV 1976
Query: 548 --SEEFEKLKQKQQEAAL-ELEELKKKREERRKVLEEEEQ------RRKQEEADRKLREE 598
S E+ +Q++AAL E+E LK K EE R++ E EQ + QE A ++L+ E
Sbjct: 1977 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2036
Query: 599 EEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIE----------- 647
E+ + + + + ++++ D L + + + + +++
Sbjct: 2037 EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2096
Query: 648 -ERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASD 701
E AE L +S ++ + ++ QAA K+ EQ + + A + A+D
Sbjct: 2097 VEEAERLKQSAEEQAQARAQAQAA-AEKLRKEAEQEAARRAQAEQAALRQKQAAD 2150
Score = 127 bits (320), Expect = 3e-29
Identities = 187/796 (23%), Positives = 348/796 (43%), Gaps = 194/796 (24%)
Query: 14 KREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNS 73
++ + RLEAE ++ + EEAAR R +R RQ EE++ Q + V A+
Sbjct: 1769 EKSKQRLEAEAGRFR---ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1825
Query: 74 VPDEEAKTTTTNTQV---EGDDEAAFLERLARREERRQKRLQE-ALERQKEFDPTI---- 125
EA T ++ E + E L RLA E +++RL+E A + + + + +
Sbjct: 1826 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1885
Query: 126 --TDASLSLPSRRMQNDTAENETTEKE--------EKSESRQERYEIE------ETETVT 169
+D+ L +++ + E+E EK+ + + E+E E
Sbjct: 1886 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1945
Query: 170 KSYQKNDWRDA--------EENKKEDKEKE-------EEEEEKPKRGSIGE-NQVEVMVE 213
+S ++ + A EE ++ + E+ EEE + ++ ++ E +++ VE
Sbjct: 1946 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 2005
Query: 214 E--KTTESQEETVVMSLKNGQISSEEPKQEEER------EQGSDEISHHEKMEEE--DKE 263
E + E E+ L+ Q ++++ Q EE+ +Q E+ + E+ D+
Sbjct: 2006 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2065
Query: 264 RAEAERARLEAEERERIKAEQDKKIADERARIE--------AEEKA-------AAQERER 308
R EAE AR AEE E + + +++ A R ++E AEE+A AA E+ R
Sbjct: 2066 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2125
Query: 309 REAEERERMREEEKRAAEERQRIKEEE----KRAAEE--RQRIKEEEKRAA--------- 353
+EAE+ R + ++AA +++ + E K+ AE+ RQ+ + E++
Sbjct: 2126 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2185
Query: 354 -------EERQRIKEEEKRAAEERQRARAEEEE-------------KAKVEEQKRNKQLE 393
EE QR+K E AA RQR++ EEE KA++E + R L
Sbjct: 2186 HQKNLLDEELQRLKAEATEAA--RQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2243
Query: 394 EKKHAMQETKIKGEKVEQKIEG---------------KWVNEKKAQEDKLQTAVLKK--Q 436
+K + + + + EK++Q E + E AQ+ L +LK+ Q
Sbjct: 2244 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2303
Query: 437 GEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEV-KSFMDRKKGFT---EVK 492
++ T+++A+ E LQ+ K E+ E+ ++ +E KE++ + + +GF E +
Sbjct: 2304 AVQEATRLKAEAELLQQQK------ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2357
Query: 493 SQNGEFMT---HKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLE------------ 537
Q M+ +LK SR RA D + + E G++L
Sbjct: 2358 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLHRTELATQEKVTL 2416
Query: 538 ----ELRRRRGETESE-----------EFEKLKQKQQEAALELEELKKKREE-------- 574
E++R++ + ++E E EKL+Q+ + L+ EE++ ++E
Sbjct: 2417 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2476
Query: 575 --------------RRKVLEEEEQRRKQEEAD-----RKLREEEEKRRLKEEIERRR--- 612
R + +E+E+ + +Q D ++LREE+++++ + E ER+R
Sbjct: 2477 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2536
Query: 613 -AEAAEKRQKMPEDGL 627
E A +RQ E+G+
Sbjct: 2537 SMEEARRRQHEAEEGV 2552
Score = 119 bits (297), Expect = 1e-26
Identities = 177/746 (23%), Positives = 308/746 (41%), Gaps = 111/746 (14%)
Query: 9 ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQ--ERLRQKQEE---------E 57
EL K +L A+ A Q D A R+ R A++ ERL+Q+ E E
Sbjct: 1110 ELEATKASLKKLRAQAEAQQPTFD----ALRDELRGAQEVGERLQQRHGERDVEVERWRE 1165
Query: 58 SLGQVTDQVE-VNAQNSVPDEEAKTTTTNTQV---EGDDEAAFLERLARREE-------- 105
+ Q+ ++ + V AQ V E + + D A+L+ RR+E
Sbjct: 1166 RVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLA 1225
Query: 106 ---------RRQKRLQEALERQ-----------KEFDPTITDASLSLPSRRMQNDTAENE 145
R+++ L E +ER K++ I D L L + + Q + +
Sbjct: 1226 DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP 1285
Query: 146 TTEKEEKSESR---QE----RYEIEETETVTKSYQK----------NDWRDAEENKKEDK 188
+ + +S S QE R E T+T Y K + R AE+ + E++
Sbjct: 1286 AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1345
Query: 189 EKEEEEE---EKPKRGSIGENQVEVMVEEKTTESQE--ETVVMSLKNGQISSEEPKQEEE 243
E+ E E EK ++ + Q + E + E Q+ + V+ + + +++ K+ +
Sbjct: 1346 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1405
Query: 244 REQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAA 303
E S +++ + ++ AER+RL EE R+ Q + +R E E +A
Sbjct: 1406 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1465
Query: 304 QERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIK--E 361
E EA++R+ E E+ + + + + + E R+K E + A E+++ ++ E
Sbjct: 1466 ARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALE 1525
Query: 362 EEKRAAEERQR--ARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVN 419
E + AEE +R +AE E +V+ Q + + EK Q
Sbjct: 1526 ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL------- 1578
Query: 420 EKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQED-KPTFKKEEIKDEKIKKDKEPKEEV 478
E+ QE+ + A L+++ E + + QA+ E+ +E+ + ++ ++K + + + EEV
Sbjct: 1579 ERSLQEEHVAVAQLREEAERRAQQ-QAEAERAREEAERELERWQLKANEALRLRLQAEEV 1637
Query: 479 KSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRL-- 536
+ E + + E + E R A + ++ + A +RL
Sbjct: 1638 AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA 1697
Query: 537 -EELRRRRGETESEE------FEKLKQKQQEAAL------ELE-ELKKKREERR-----K 577
+EL R R ETE E E+L + Q+EAA ELE EL K R E K
Sbjct: 1698 EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1757
Query: 578 VLEEEEQRRKQEEADRKLREEEEK-RRLKEEIERRRA---EAAEKRQKMPEDGLSDDKKP 633
EEE R E++ ++L E + R L EE R RA EA +RQ ED +
Sbjct: 1758 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1817
Query: 634 FKCFTPK----GSSLKIEERAEFLNK 655
+ K G + +++ AE K
Sbjct: 1818 ERVLAEKLAAIGEATRLKTEAEIALK 1843
Score = 85.9 bits (211), Expect = 1e-16
Identities = 107/442 (24%), Positives = 204/442 (46%), Gaps = 84/442 (19%)
Query: 1 MDDFERRRELRRQKREEMRLEAERIAYQRNDDDE---------EEAARERRRRARQER-- 49
+++ + ++ L ++ + ++ EA A QR+ +E EE ++ + R + R
Sbjct: 2181 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2240
Query: 50 -LRQK--------QEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERL 100
LR K +E E + QV ++ A+ SV +EA + + + A E++
Sbjct: 2241 ILRDKDNTQRFLQEEAEKMKQVAEEA---ARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2297
Query: 101 ------ARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSE 154
A +E R K E L++QKE +RR+Q D E + E+++
Sbjct: 2298 LKEKMQAVQEATRLKAEAELLQQQKEL--------AQEQARRLQED-KEQMAQQLAEETQ 2348
Query: 155 SRQERYEIEETETVTKS--YQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGE--NQVEV 210
Q E E + S ++ R AE ++ + + +E+ + + + IGE ++ E+
Sbjct: 2349 GFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL 2408
Query: 211 MVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERA 270
+EK T Q + + + + + E+ + I+ E+ E++K + EA+
Sbjct: 2409 ATQEKVTLVQ-----------TLEIQRQQSDHDAERLREAIAELER--EKEKLQQEAKLL 2455
Query: 271 RLEAEERERIKAEQ--------------DKKIADERARIEAEEKAAAQERERREAEERER 316
+L++EE + ++ EQ +K +R R +EKA ++ + E + ++
Sbjct: 2456 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ 2515
Query: 317 MREEEKR----AAEERQRI---KEEEKR---AAEERQRIKEEEKRAAEERQRIKEEEKRA 366
+REE++R +ERQR+ EE +R AEE R K+EE + E+++R ++E+
Sbjct: 2516 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRR--QQEELL 2573
Query: 367 AEERQRARAEEEEKAKVEEQKR 388
AEE QR R E+ +EEQ R
Sbjct: 2574 AEENQRLR---EQLQLLEEQHR 2592
Score = 83.6 bits (205), Expect = 7e-16
Identities = 116/504 (23%), Positives = 218/504 (43%), Gaps = 99/504 (19%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEE---------EAARERRRRARQERLRQKQEE 56
R++ Q+ +RL+ E +Q+N DEE EAAR+R + +E + +
Sbjct: 2165 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ-VEEELFSVRVQM 2223
Query: 57 ESLGQVTDQVEV-----------NAQNSVPDEEAKTTTTNTQVE----GDDEAAFLERLA 101
E L ++ ++E N Q + +E K + EAA L +LA
Sbjct: 2224 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2283
Query: 102 RREERRQKRLQEALERQK-----EFDPTITDASLSLPSRRMQNDTAENETTEKE------ 150
+ +Q+ L E + ++K E +A L + + + A +KE
Sbjct: 2284 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2343
Query: 151 -EKSESRQERYEIEETETVTKSYQKN--DWRDAEENKKEDKEKEEEEEEKPKRGSIGE-- 205
E+++ Q E E + S + R AE ++ + + +E+ + + + IGE
Sbjct: 2344 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2403
Query: 206 NQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERA 265
++ E+ +EK T Q + + + + + E+ + I+ E+ E++K +
Sbjct: 2404 HRTELATQEKVTLVQT-----------LEIQRQQSDHDAERLREAIAELER--EKEKLQQ 2450
Query: 266 EAERARLEAEERERIKAEQ----------------------DKKIADERARIEA---EEK 300
EA+ +L++EE + ++ EQ ++ I E+A++E +E
Sbjct: 2451 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV 2510
Query: 301 AAAQ----ERERREAE-ERERMR-----EEEKRA---AEERQRIKEEEKRAAEERQRIKE 347
A AQ E++R++ + E+ER R EE +R AEE R K+EE + E+++R +
Sbjct: 2511 AKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRR--Q 2568
Query: 348 EEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGE 407
+E+ AEE QR++ E+ + EE+ RA E+ + K L + A+ + E
Sbjct: 2569 QEELLAEENQRLR-EQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAE 2627
Query: 408 KVEQKIEGKWVNEKKAQEDKLQTA 431
E +G +K +LQ A
Sbjct: 2628 P-EHSFDGL---RRKVSAQRLQEA 2647
Score = 75.9 bits (185), Expect = 1e-13
Identities = 104/460 (22%), Positives = 202/460 (43%), Gaps = 57/460 (12%)
Query: 246 QGSDEI--SHHEKMEEEDKERA-----EAERARLEAEERERIKAEQDKKIADERARIEAE 298
QG++E+ +H E+++E A EA +A L ++ R +AE + D + E
Sbjct: 1085 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASL---KKLRAQAEAQQPTFD---ALRDE 1138
Query: 299 EKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQR 358
+ A + ER + ER E E+ Q ++ + A+ R +E E+ + R
Sbjct: 1139 LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY 1198
Query: 359 IKEEEKRAAEERQRARAEEEEKAK--VEEQKRNKQLEEKKHAMQETKIKGEKVE--QKIE 414
+ + A + R +E+ +A + Q +QL +++ ++E + GEKVE Q+
Sbjct: 1199 RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1258
Query: 415 GKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEP 474
+++N K E LQ K Q E + AK+ K+Q
Sbjct: 1259 KQYINAIKDYE--LQLVTYKAQLEPVAS--PAKKPKVQSGS------------------- 1295
Query: 475 KEEVKSFMDRKKGFTE---VKSQNGEFMTHKLKHTENTFSRPGGRASVDTKE--AEGAPQ 529
+ ++ ++D + ++E + SQ +F++ L+ E R + + +E AE
Sbjct: 1296 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE-ERLAEQQRAEERERLAEVEAA 1354
Query: 530 VEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQE 589
+E ++L E + E ++L+Q+ QE + EE +++++ ++EE Q+ +Q
Sbjct: 1355 LEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS 1414
Query: 590 ---EADRKLRE----EEEKRRLKEEIE--RRRAEAAEKRQKMPEDGLSDDKKPFKCFTPK 640
E K R+ E + R++EEI R + EA E+++ E L + + +
Sbjct: 1415 SEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA--RAEEAE 1472
Query: 641 GSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLE 680
+ +E AE L + VQ S K + + S++ + E
Sbjct: 1473 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1512
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 144 bits (363), Expect = 3e-34
Identities = 154/665 (23%), Positives = 306/665 (46%), Gaps = 64/665 (9%)
Query: 15 REEMRLEAERIAYQRND------DDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEV 68
+ E+ LE RI D E EAAR+R+ A +ER R++ EE + + E
Sbjct: 1968 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA 2027
Query: 69 NAQNSVPDEEAKTTTTNTQV------EGDDEAAFLERLARREERRQKRLQE--------A 114
Q EE + + + E+A +LA +E QKRLQ
Sbjct: 2028 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA--QEAAQKRLQAEEKAHAFAV 2085
Query: 115 LERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEE-----KSESRQERYEIEETETVT 169
++++E T+ L R + + A E EE + E+ Q R ++EE E +
Sbjct: 2086 QQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK 2145
Query: 170 KSYQKNDWRDAEENKKEDKEKEEEEEEKPKRG-----SIGENQVEVMVEEKTTESQEETV 224
+S ++ A+ +K ++E E+E +R ++ + Q EK + E+T+
Sbjct: 2146 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2205
Query: 225 VMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQ 284
+ Q + Q EE + + + E+++ E EA R R + EE Q
Sbjct: 2206 RQKAQVEQELTTLRLQLEETDHQKNLLD--EELQRLKAEATEAARQRSQVEEELFSVRVQ 2263
Query: 285 DKKIADERARIEAEEKAA-------AQERERREAEERERMREEEKR---AAEERQRIKE- 333
++++ +ARIEAE +A Q + EAE+ +++ EE R AA+E R+++
Sbjct: 2264 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2323
Query: 334 EEKRAAEER---QRIKEEEKRAAEERQRIKEE------EKRAAEERQRARAEEEEKAKV- 383
E+ A++R +++ +E+ +A +E R+K E +K A+E+ R E++E+
Sbjct: 2324 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ 2383
Query: 384 ---EEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEK 440
E Q + LE ++ E + E+++ ++ + +A+ED + +KQ EE
Sbjct: 2384 LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR---FRKQAEEI 2440
Query: 441 GTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMT 500
G K+ QE + EI+ ++ D E E + ++R+K + +++ + +
Sbjct: 2441 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS 2500
Query: 501 HKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQE 560
+++ + +A + +E ++ + +E+ + + + +E K +Q ++E
Sbjct: 2501 EEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE 2560
Query: 561 AALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAE-AAEKR 619
+ ++++++R+ R V EE RR+Q EA+ +R ++E+ + E+ R++ E AE+
Sbjct: 2561 QQRQQQQMEQERQ--RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEEN 2618
Query: 620 QKMPE 624
Q++ E
Sbjct: 2619 QRLRE 2623
Score = 137 bits (346), Expect = 3e-32
Identities = 171/744 (22%), Positives = 340/744 (45%), Gaps = 106/744 (14%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDD--------------------EEEAARERRRRA 45
R+REL Q+ E+ R AE A QR + EEE AR +R A
Sbjct: 1712 RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA 1771
Query: 46 RQERLRQKQEEESLGQVTDQVEVN-AQNSVPDEEAKTTTTNTQV----------EGDDEA 94
+ RQ+ E E L +V ++EV A + +EE+++T+ ++ E +EA
Sbjct: 1772 AATQKRQELEAE-LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1830
Query: 95 AFLERLARREERRQKRLQEALERQK---------------EFDPTITDASLSLPSRRMQN 139
A L LA +R+++ +E RQ+ E T+A ++L + +N
Sbjct: 1831 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1890
Query: 140 DT----AENETTEKEEKSE-SRQERYEIEETETVTKSYQKNDWRD----AEENKKEDKEK 190
+ AE+E ++ E + Q + +IEE + ++ E+ ++ ++
Sbjct: 1891 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1950
Query: 191 EEEE---EEKPKRGSIGENQVEVMV------EEKTTESQEETVVMSLKNGQISSEEPKQE 241
EEE + ++ + G+ ++E+ + E T S+E+ + + + Q+++EE ++
Sbjct: 1951 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 2010
Query: 242 EEREQ-------GSDEISHHEK--MEEEDKERAEAERARLEAEERERIKAEQDKKIADER 292
E E+ +E + K +EE ++ +A+ E AR E E+ A Q ++A E
Sbjct: 2011 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ-LQLAQEA 2069
Query: 293 A--RIEAEEKAAAQERERREAEERERMREEE------KRAAEERQRIKEEEKRAAEERQR 344
A R++AEEKA A +++E E ++ +++E+ + AE +R EE + A + +R
Sbjct: 2070 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2129
Query: 345 IKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKI 404
+ +R EE +R+K+ + A+ R +A+A E+ K EQ+ ++ + ++ A+++ +
Sbjct: 2130 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2189
Query: 405 KGEKVE--QKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEE 462
++E +K + + +K E +L T L+ Q EE + E+LQ K
Sbjct: 2190 ADAEMEKHKKFAEQTLRQKAQVEQELTT--LRLQLEETDHQKNLLDEELQRLKAE----- 2242
Query: 463 IKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQ-NGEFMTHKLKHTENTFSRPGGRASVDT 521
E ++ + +EE+ S + + +++K++ E L+ +NT A
Sbjct: 2243 -ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2301
Query: 522 KEAEGAPQV----EAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKRE--ER 575
+ AE A ++ + RL +L + EK+ +++ +A E LK + E ++
Sbjct: 2302 QVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2361
Query: 576 RKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFK 635
+K L +E+ RR QE+ +E+ ++L EE + + +RQ+ E ++ +
Sbjct: 2362 QKELAQEQARRLQED------KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR 2415
Query: 636 CFTPKGSSLKIEERAEFLNKSVQK 659
+ + EE A+ K ++
Sbjct: 2416 VAEMSRAQARAEEDAQRFRKQAEE 2439
Score = 129 bits (323), Expect = 1e-29
Identities = 193/835 (23%), Positives = 344/835 (41%), Gaps = 151/835 (18%)
Query: 9 ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRR---------RARQER----LRQKQE 55
E R+ EE RL ++ A +R E EAA E++R +A+ ER L+Q+ +
Sbjct: 1366 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1425
Query: 56 EESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVE-----GDDEAAFLERLARREERRQKR 110
EE + + V+ Q EE + +++ E EAA RL EE R R
Sbjct: 1426 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1485
Query: 111 LQ-EALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIE-----E 164
LQ EA ERQ+ A L + R + + AE + + +E++E + + + E +
Sbjct: 1486 LQLEATERQRG------GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1539
Query: 165 TETVTKSYQKNDWRDAEENKK-----EDKEKEEEEEEKPKRGSIGEN--QVEVMVE---- 213
E S K + A E ++ E+ + EE E+ R + E QV+V +E
Sbjct: 1540 AEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1599
Query: 214 --------------EKTTE-----SQEETVVMSLKNG-------QISSEEPKQEEERE-- 245
EKT + +E V L+ Q +E ++E ERE
Sbjct: 1600 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1659
Query: 246 ---------------------QGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQ 284
Q S + EK +EE + A E R+R AEQ
Sbjct: 1660 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1719
Query: 285 DKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQR 344
+ + + A A+++ AA++ R E E+ ++ + EE R++ E A ++RQ
Sbjct: 1720 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1779
Query: 345 IKEEEKRAAEERQRI------KEEEKRAAEERQRARAEEEE-------------KAKVEE 385
++ E + E + + EEE R+ E+ + R E E +A EE
Sbjct: 1780 LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE 1839
Query: 386 QKRNKQLEEKKHAMQETKIK----------GEKVEQKIEGK-WVNEKKAQEDKLQTAVLK 434
KR +QL E+ A Q + + GE K E + + EK+A+ ++L+
Sbjct: 1840 AKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1899
Query: 435 KQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQ 494
+ + + + QA + K ++ + + D ++++ K E+ + R++ E+ +
Sbjct: 1900 EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED--TLRQRRQVEEEILAL 1957
Query: 495 NGEFMTHKLKHTENTFSRPGGRASV-DTKEAEGAPQVEAGKR----LEELRRRRGETE-- 547
F E R++ DT ++ ++EA ++ EE RRRR E
Sbjct: 1958 KASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV 2017
Query: 548 --SEEFEKLKQKQQEAAL-ELEELKKKREERRKVLEEEEQ------RRKQEEADRKLREE 598
S E+ +Q++AAL E+E LK K EE R++ E EQ + QE A ++L+ E
Sbjct: 2018 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2077
Query: 599 EEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIE----------- 647
E+ + + + + ++++ D L + + + + +++
Sbjct: 2078 EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2137
Query: 648 -ERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASD 701
E AE L +S ++ + ++ QAA K+ EQ + + A + A+D
Sbjct: 2138 VEEAERLKQSAEEQAQARAQAQAA-AEKLRKEAEQEAARRAQAEQAALRQKQAAD 2191
Score = 127 bits (320), Expect = 3e-29
Identities = 187/796 (23%), Positives = 348/796 (43%), Gaps = 194/796 (24%)
Query: 14 KREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNS 73
++ + RLEAE ++ + EEAAR R +R RQ EE++ Q + V A+
Sbjct: 1810 EKSKQRLEAEAGRFR---ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1866
Query: 74 VPDEEAKTTTTNTQV---EGDDEAAFLERLARREERRQKRLQE-ALERQKEFDPTI---- 125
EA T ++ E + E L RLA E +++RL+E A + + + + +
Sbjct: 1867 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1926
Query: 126 --TDASLSLPSRRMQNDTAENETTEKE--------EKSESRQERYEIE------ETETVT 169
+D+ L +++ + E+E EK+ + + E+E E
Sbjct: 1927 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1986
Query: 170 KSYQKNDWRDA--------EENKKEDKEKE-------EEEEEKPKRGSIGE-NQVEVMVE 213
+S ++ + A EE ++ + E+ EEE + ++ ++ E +++ VE
Sbjct: 1987 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 2046
Query: 214 E--KTTESQEETVVMSLKNGQISSEEPKQEEER------EQGSDEISHHEKMEEE--DKE 263
E + E E+ L+ Q ++++ Q EE+ +Q E+ + E+ D+
Sbjct: 2047 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2106
Query: 264 RAEAERARLEAEERERIKAEQDKKIADERARIE--------AEEKA-------AAQERER 308
R EAE AR AEE E + + +++ A R ++E AEE+A AA E+ R
Sbjct: 2107 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2166
Query: 309 REAEERERMREEEKRAAEERQRIKEEE----KRAAEE--RQRIKEEEKRAA--------- 353
+EAE+ R + ++AA +++ + E K+ AE+ RQ+ + E++
Sbjct: 2167 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2226
Query: 354 -------EERQRIKEEEKRAAEERQRARAEEEE-------------KAKVEEQKRNKQLE 393
EE QR+K E AA RQR++ EEE KA++E + R L
Sbjct: 2227 HQKNLLDEELQRLKAEATEAA--RQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2284
Query: 394 EKKHAMQETKIKGEKVEQKIEG---------------KWVNEKKAQEDKLQTAVLKK--Q 436
+K + + + + EK++Q E + E AQ+ L +LK+ Q
Sbjct: 2285 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2344
Query: 437 GEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEV-KSFMDRKKGFT---EVK 492
++ T+++A+ E LQ+ K E+ E+ ++ +E KE++ + + +GF E +
Sbjct: 2345 AVQEATRLKAEAELLQQQK------ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2398
Query: 493 SQNGEFMT---HKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLE------------ 537
Q M+ +LK SR RA D + + E G++L
Sbjct: 2399 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLHRTELATQEKVTL 2457
Query: 538 ----ELRRRRGETESE-----------EFEKLKQKQQEAALELEELKKKREE-------- 574
E++R++ + ++E E EKL+Q+ + L+ EE++ ++E
Sbjct: 2458 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2517
Query: 575 --------------RRKVLEEEEQRRKQEEAD-----RKLREEEEKRRLKEEIERRR--- 612
R + +E+E+ + +Q D ++LREE+++++ + E ER+R
Sbjct: 2518 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2577
Query: 613 -AEAAEKRQKMPEDGL 627
E A +RQ E+G+
Sbjct: 2578 SMEEARRRQHEAEEGV 2593
Score = 119 bits (297), Expect = 1e-26
Identities = 177/746 (23%), Positives = 308/746 (41%), Gaps = 111/746 (14%)
Query: 9 ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQ--ERLRQKQEE---------E 57
EL K +L A+ A Q D A R+ R A++ ERL+Q+ E E
Sbjct: 1151 ELEATKASLKKLRAQAEAQQPTFD----ALRDELRGAQEVGERLQQRHGERDVEVERWRE 1206
Query: 58 SLGQVTDQVE-VNAQNSVPDEEAKTTTTNTQV---EGDDEAAFLERLARREE-------- 105
+ Q+ ++ + V AQ V E + + D A+L+ RR+E
Sbjct: 1207 RVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLA 1266
Query: 106 ---------RRQKRLQEALERQ-----------KEFDPTITDASLSLPSRRMQNDTAENE 145
R+++ L E +ER K++ I D L L + + Q + +
Sbjct: 1267 DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP 1326
Query: 146 TTEKEEKSESR---QE----RYEIEETETVTKSYQK----------NDWRDAEENKKEDK 188
+ + +S S QE R E T+T Y K + R AE+ + E++
Sbjct: 1327 AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1386
Query: 189 EKEEEEE---EKPKRGSIGENQVEVMVEEKTTESQE--ETVVMSLKNGQISSEEPKQEEE 243
E+ E E EK ++ + Q + E + E Q+ + V+ + + +++ K+ +
Sbjct: 1387 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1446
Query: 244 REQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAA 303
E S +++ + ++ AER+RL EE R+ Q + +R E E +A
Sbjct: 1447 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1506
Query: 304 QERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIK--E 361
E EA++R+ E E+ + + + + + E R+K E + A E+++ ++ E
Sbjct: 1507 ARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALE 1566
Query: 362 EEKRAAEERQR--ARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVN 419
E + AEE +R +AE E +V+ Q + + EK Q
Sbjct: 1567 ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL------- 1619
Query: 420 EKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQED-KPTFKKEEIKDEKIKKDKEPKEEV 478
E+ QE+ + A L+++ E + + QA+ E+ +E+ + ++ ++K + + + EEV
Sbjct: 1620 ERSLQEEHVAVAQLREEAERRAQQ-QAEAERAREEAERELERWQLKANEALRLRLQAEEV 1678
Query: 479 KSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRL-- 536
+ E + + E + E R A + ++ + A +RL
Sbjct: 1679 AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA 1738
Query: 537 -EELRRRRGETESEE------FEKLKQKQQEAAL------ELE-ELKKKREERR-----K 577
+EL R R ETE E E+L + Q+EAA ELE EL K R E K
Sbjct: 1739 EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1798
Query: 578 VLEEEEQRRKQEEADRKLREEEEK-RRLKEEIERRRA---EAAEKRQKMPEDGLSDDKKP 633
EEE R E++ ++L E + R L EE R RA EA +RQ ED +
Sbjct: 1799 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1858
Query: 634 FKCFTPK----GSSLKIEERAEFLNK 655
+ K G + +++ AE K
Sbjct: 1859 ERVLAEKLAAIGEATRLKTEAEIALK 1884
Score = 85.9 bits (211), Expect = 1e-16
Identities = 107/442 (24%), Positives = 204/442 (46%), Gaps = 84/442 (19%)
Query: 1 MDDFERRRELRRQKREEMRLEAERIAYQRNDDDE---------EEAARERRRRARQER-- 49
+++ + ++ L ++ + ++ EA A QR+ +E EE ++ + R + R
Sbjct: 2222 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2281
Query: 50 -LRQK--------QEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERL 100
LR K +E E + QV ++ A+ SV +EA + + + A E++
Sbjct: 2282 ILRDKDNTQRFLQEEAEKMKQVAEEA---ARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2338
Query: 101 ------ARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSE 154
A +E R K E L++QKE +RR+Q D E + E+++
Sbjct: 2339 LKEKMQAVQEATRLKAEAELLQQQKEL--------AQEQARRLQED-KEQMAQQLAEETQ 2389
Query: 155 SRQERYEIEETETVTKS--YQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGE--NQVEV 210
Q E E + S ++ R AE ++ + + +E+ + + + IGE ++ E+
Sbjct: 2390 GFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL 2449
Query: 211 MVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERA 270
+EK T Q + + + + + E+ + I+ E+ E++K + EA+
Sbjct: 2450 ATQEKVTLVQ-----------TLEIQRQQSDHDAERLREAIAELER--EKEKLQQEAKLL 2496
Query: 271 RLEAEERERIKAEQ--------------DKKIADERARIEAEEKAAAQERERREAEERER 316
+L++EE + ++ EQ +K +R R +EKA ++ + E + ++
Sbjct: 2497 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ 2556
Query: 317 MREEEKR----AAEERQRI---KEEEKR---AAEERQRIKEEEKRAAEERQRIKEEEKRA 366
+REE++R +ERQR+ EE +R AEE R K+EE + E+++R ++E+
Sbjct: 2557 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRR--QQEELL 2614
Query: 367 AEERQRARAEEEEKAKVEEQKR 388
AEE QR R E+ +EEQ R
Sbjct: 2615 AEENQRLR---EQLQLLEEQHR 2633
Score = 83.6 bits (205), Expect = 7e-16
Identities = 116/504 (23%), Positives = 218/504 (43%), Gaps = 99/504 (19%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEE---------EAARERRRRARQERLRQKQEE 56
R++ Q+ +RL+ E +Q+N DEE EAAR+R + +E + +
Sbjct: 2206 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ-VEEELFSVRVQM 2264
Query: 57 ESLGQVTDQVEV-----------NAQNSVPDEEAKTTTTNTQVE----GDDEAAFLERLA 101
E L ++ ++E N Q + +E K + EAA L +LA
Sbjct: 2265 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2324
Query: 102 RREERRQKRLQEALERQK-----EFDPTITDASLSLPSRRMQNDTAENETTEKE------ 150
+ +Q+ L E + ++K E +A L + + + A +KE
Sbjct: 2325 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2384
Query: 151 -EKSESRQERYEIEETETVTKSYQKN--DWRDAEENKKEDKEKEEEEEEKPKRGSIGE-- 205
E+++ Q E E + S + R AE ++ + + +E+ + + + IGE
Sbjct: 2385 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2444
Query: 206 NQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERA 265
++ E+ +EK T Q + + + + + E+ + I+ E+ E++K +
Sbjct: 2445 HRTELATQEKVTLVQT-----------LEIQRQQSDHDAERLREAIAELER--EKEKLQQ 2491
Query: 266 EAERARLEAEERERIKAEQ----------------------DKKIADERARIEA---EEK 300
EA+ +L++EE + ++ EQ ++ I E+A++E +E
Sbjct: 2492 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV 2551
Query: 301 AAAQ----ERERREAE-ERERMR-----EEEKRA---AEERQRIKEEEKRAAEERQRIKE 347
A AQ E++R++ + E+ER R EE +R AEE R K+EE + E+++R +
Sbjct: 2552 AKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRR--Q 2609
Query: 348 EEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGE 407
+E+ AEE QR++ E+ + EE+ RA E+ + K L + A+ + E
Sbjct: 2610 QEELLAEENQRLR-EQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAE 2668
Query: 408 KVEQKIEGKWVNEKKAQEDKLQTA 431
E +G +K +LQ A
Sbjct: 2669 P-EHSFDGL---RRKVSAQRLQEA 2688
Score = 75.9 bits (185), Expect = 1e-13
Identities = 104/460 (22%), Positives = 202/460 (43%), Gaps = 57/460 (12%)
Query: 246 QGSDEI--SHHEKMEEEDKERA-----EAERARLEAEERERIKAEQDKKIADERARIEAE 298
QG++E+ +H E+++E A EA +A L ++ R +AE + D + E
Sbjct: 1126 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASL---KKLRAQAEAQQPTFD---ALRDE 1179
Query: 299 EKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQR 358
+ A + ER + ER E E+ Q ++ + A+ R +E E+ + R
Sbjct: 1180 LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY 1239
Query: 359 IKEEEKRAAEERQRARAEEEEKAK--VEEQKRNKQLEEKKHAMQETKIKGEKVE--QKIE 414
+ + A + R +E+ +A + Q +QL +++ ++E + GEKVE Q+
Sbjct: 1240 RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1299
Query: 415 GKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEP 474
+++N K E LQ K Q E + AK+ K+Q
Sbjct: 1300 KQYINAIKDYE--LQLVTYKAQLEPVAS--PAKKPKVQSGS------------------- 1336
Query: 475 KEEVKSFMDRKKGFTE---VKSQNGEFMTHKLKHTENTFSRPGGRASVDTKE--AEGAPQ 529
+ ++ ++D + ++E + SQ +F++ L+ E R + + +E AE
Sbjct: 1337 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE-ERLAEQQRAEERERLAEVEAA 1395
Query: 530 VEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQE 589
+E ++L E + E ++L+Q+ QE + EE +++++ ++EE Q+ +Q
Sbjct: 1396 LEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS 1455
Query: 590 ---EADRKLRE----EEEKRRLKEEIE--RRRAEAAEKRQKMPEDGLSDDKKPFKCFTPK 640
E K R+ E + R++EEI R + EA E+++ E L + + +
Sbjct: 1456 SEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA--RAEEAE 1513
Query: 641 GSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLE 680
+ +E AE L + VQ S K + + S++ + E
Sbjct: 1514 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1553
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 142 bits (359), Expect = 9e-34
Identities = 113/401 (28%), Positives = 212/401 (52%), Gaps = 49/401 (12%)
Query: 71 QNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASL 130
+N++ DEE K Q ++ +E + K L+ LER K L
Sbjct: 199 RNTITDEELKEKNAKLQ----EKLQLVESEKSEIQLNVKELKRKLERAK----------L 244
Query: 131 SLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKND---WRDAEENKKED 187
LP +++Q AE + KE +S S + + ++EE E + Q+ + WR EE +E
Sbjct: 245 LLPQQQLQ---AEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQ-EEKIQER 300
Query: 188 KEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQG 247
+EK +E+EEK + + E M+ EK + + + +M K +I E K E+
Sbjct: 301 EEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQ---- 356
Query: 248 SDEISHHEKMEEEDKERAEAERARLEAEERERIKAE---QDKKIADERARIEAEEKAAAQ 304
EK+ E++++R E E+ R E E+R+ +A+ Q++KI ++ +I +E+ Q
Sbjct: 357 -------EKIREQEEKRQEEEKIR-EQEKRQEQEAKMWRQEEKIREQEEKIREQEEMM-Q 407
Query: 305 ERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEK 364
E+E + E+ E+M E+E+ E+ ++++ +E++ E+ ++I+E+E++ E+ + ++E+E+
Sbjct: 408 EQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEE 467
Query: 365 RAAE------ERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIK--GEKVEQKIEGK 416
+ E E++ E+EEK + +E+K +Q EKK QE KI+ E ++++ E
Sbjct: 468 KMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQ--EKKIREQEEKIREQEEMMQEQEEKM 525
Query: 417 WVNEKK--AQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDK 455
W E+K QE+K+Q K + +E+ + Q R + QE+K
Sbjct: 526 WEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEK 566
Score = 135 bits (341), Expect = 1e-31
Identities = 134/568 (23%), Positives = 280/568 (49%), Gaps = 86/568 (15%)
Query: 104 EERRQKRLQEALER----QKEFDPTITDASLSLPSRRMQNDTAENETT--------EKEE 151
+E RQ +L EA E+ + +P++ A+ +++ N T TT ++++
Sbjct: 41 KETRQSKLAEAKEQLTDHHPQTNPSVGTAASDTKKKKINNGTNPETTTSGGCHSPEDEQK 100
Query: 152 KSESRQE--RYEIE------------ETETVTKSYQ--------KNDWRDAEENKKEDKE 189
S QE R E+E +TE Y + + RD + +
Sbjct: 101 ASHQHQEALRRELEAQVQTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDSWK 160
Query: 190 KEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSD 249
E E+ + + + + +EE T E + + + L I+ EE K++ + Q
Sbjct: 161 FAGELEQALSAVATQKKKADRYIEELTKE--RDALSLELYRNTITDEELKEKNAKLQEKL 218
Query: 250 EISHHEKMEEE---DKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQER 306
++ EK E + + + + ERA+L +++ ++AE D + E + A+ +A +E
Sbjct: 219 QLVESEKSEIQLNVKELKRKLERAKLLLPQQQ-LQAEADH-LGKELQSVSAKLQAQVEEN 276
Query: 307 E---RREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEE 363
E R ++ E+M +E++ E ++I+E+E++ E+ ++++ +E+ E+ ++++ +E
Sbjct: 277 ELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQE 336
Query: 364 KRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGK-WVNEKK 422
+ E+ ++ R EE K+ EQ++ ++ EEK+ +E KI+ ++ Q+ E K W E+K
Sbjct: 337 EMMWEKEEKIRELEE---KMHEQEKIREQEEKRQ--EEEKIREQEKRQEQEAKMWRQEEK 391
Query: 423 AQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIK----DEKIKK-DKEPKEE 477
+E + + ++ +E+ K+ + EK+ E + +++E K +EKI++ +K+ +E+
Sbjct: 392 IREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQ 451
Query: 478 VKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLE 537
+ ++++ E + + GE +E + Q EA + +
Sbjct: 452 EEKIREQEEMMQEQEEKMGE------------------------QEGKMCEQ-EAKMQEQ 486
Query: 538 ELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLRE 597
E + RR E + E EK ++Q+E E EE+ +++EE K+ E+EE+ +QEE K++E
Sbjct: 487 EEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEE--KMWEQEEKMCEQEE---KMQE 541
Query: 598 EEEKRRLKEE-IERRRAEAAEKRQKMPE 624
+EEK R +EE + + ++ +KM E
Sbjct: 542 QEEKMRRQEEKMREQEVRLRQQEEKMQE 569
Score = 130 bits (326), Expect = 6e-30
Identities = 108/411 (26%), Positives = 210/411 (51%), Gaps = 48/411 (11%)
Query: 5 ERRRELRRQKREEMRL-EAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVT 63
E +E + +E+++L E+E+ Q N + + + Q++L+ E + LG+
Sbjct: 205 EELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQA--EADHLGKEL 262
Query: 64 DQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDP 123
V Q V + E N Q E E++ R+EE+ Q+R +E ++ Q+E
Sbjct: 263 QSVSAKLQAQVEENEL-WNRLNQQQE--------EKMWRQEEKIQER-EEKIQEQEE--- 309
Query: 124 TITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEEN 183
+ + + E EKEEK RQE E+ E + + +K +E
Sbjct: 310 -------KIREQEEKMRRQEEMMWEKEEKMR-RQEEMMWEKEEKIRELEEK---MHEQEK 358
Query: 184 KKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEE 243
+E +EK +EEE+ ++ E + ++ +E+ QEE + EE QE+E
Sbjct: 359 IREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKI--------REQEEMMQEQE 410
Query: 244 REQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAA 303
+ G E EKM E+++E E E EE+ R EQ+KKI ++ +I E++
Sbjct: 411 EKMGEQE----EKMWEQEEEMQEQEEKMRRQEEKIR---EQEKKIREQEEKIR-EQEEMM 462
Query: 304 QERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEE 363
QE+E + E+ +M E+E + E+ ++++ +E++ E+ ++I+E+E++ E+ + ++E+E
Sbjct: 463 QEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQE 522
Query: 364 KRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIE 414
++ E+ ++ E+EEK + +E+K +Q EEK M+E +++ + E+K++
Sbjct: 523 EKMWEQEEK-MCEQEEKMQEQEEKMRRQ-EEK---MREQEVRLRQQEEKMQ 568
Score = 123 bits (308), Expect = 8e-28
Identities = 106/472 (22%), Positives = 236/472 (50%), Gaps = 40/472 (8%)
Query: 32 DDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVN---AQNSVPDEEAKTTTTNTQV 88
+DE++A+ + + R+E Q Q L ++++ +Q++V E + +++
Sbjct: 96 EDEQKASHQHQEALRRELEAQVQTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRL 155
Query: 89 E------GDDEAAFLERLARREERRQKRLQEALERQKE-----FDPTITDASLSLPSRRM 137
G+ E A L +A ++++ + ++E + + + TITD L + ++
Sbjct: 156 HDSWKFAGELEQA-LSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKL 214
Query: 138 QNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRD--AEENKKEDKEKEEEEE 195
Q E+ + E + ++ + ++E + + Q D +E + + + + E
Sbjct: 215 QEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVE 274
Query: 196 EKPKRGSIGENQVEVM--VEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISH 253
E + + Q E M EEK E +E+ K + + +QEE + +++
Sbjct: 275 ENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRR 334
Query: 254 HEKM--EEEDKERAEAERARLEAEERER-IKAEQDKKIADERARIEAEEKAAAQERERRE 310
E+M E+E+K R E+ + + RE+ K ++++KI ++ R E E K QE + RE
Sbjct: 335 QEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIRE 394
Query: 311 AEER------------ERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQR 358
EE+ E+M E+E++ E+ + ++E+E++ + ++I+E+EK+ E+ ++
Sbjct: 395 QEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEK 454
Query: 359 IKEEEKRAAEERQRARAEE----EEKAKVEEQKRNKQLEEKKHAMQETKIK--GEKVEQK 412
I+E+E+ E+ ++ +E E++AK++EQ+ + +E+K QE KI+ EK+ ++
Sbjct: 455 IREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQ 514
Query: 413 IEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIK 464
E E+K E + + +++ +E+ K++ + EK++E + +++E K
Sbjct: 515 EEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEK 566
Score = 90.1 bits (222), Expect = 7e-18
Identities = 78/337 (23%), Positives = 164/337 (48%), Gaps = 45/337 (13%)
Query: 1 MDDFERRRELRRQKREEMRLEAERIAYQRN--DDDEEEAARERRRRARQERLRQKQEEES 58
+++ E L +Q+ E+M + E+I + + EE+ + + RQE + ++EE+
Sbjct: 273 VEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKM 332
Query: 59 LGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQ 118
Q +++ + + + E K E +++ E++ +E+R+++ + + RQ
Sbjct: 333 RRQ--EEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQ--EAKMWRQ 388
Query: 119 KEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWR 178
+E + E+EEK ++E + E+ E + + +K +
Sbjct: 389 EE------------------------KIREQEEKIREQEEMMQ-EQEEKMGEQEEKMWEQ 423
Query: 179 DAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEP 238
+ E ++E+K + +EE+ + + I E + ++ +E+ + QEE M + G++ +E
Sbjct: 424 EEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEK--MGEQEGKMCEQEA 481
Query: 239 KQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAE 298
K +E+ E+ + EK+ E++K+ E E + E+E + EQ++K+ E E
Sbjct: 482 KMQEQEEKMRRQ---EEKIREQEKKIREQEE---KIREQEEMMQEQEEKM------WEQE 529
Query: 299 EKAAAQERERREAEERERMREEEKRAAEERQRIKEEE 335
EK QE + +E EE+ R +EE+ R E R R +EE+
Sbjct: 530 EKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEK 566
Score = 88.6 bits (218), Expect = 2e-17
Identities = 95/408 (23%), Positives = 192/408 (47%), Gaps = 45/408 (11%)
Query: 271 RLEAEERERIKAEQDK-KIADERARIEAEEKAAAQERERREAEERERMREEEKRAAE-ER 328
+LE E R+ I D K A E +E A A ++++ + E +E + + E R
Sbjct: 143 QLEGEARDLISRLHDSWKFAGE---LEQALSAVATQKKKADRYIEELTKERDALSLELYR 199
Query: 329 QRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAE-EEEKAKVEEQK 387
I +EE + E+ +++E+ + E+ I+ K + +RA+ +++ + E
Sbjct: 200 NTITDEELK--EKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADH 257
Query: 388 RNKQLEEKKHAMQ----ETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTK 443
K+L+ +Q E ++ +Q+ E W E+K QE + + +++ E+ K
Sbjct: 258 LGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEK 317
Query: 444 VQAKREKLQEDKPTFKKEEI----KDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFM 499
++ + E + E + +++E K+EKI++ +E E + ++ E K Q E +
Sbjct: 318 MRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQ-----EEKRQEEEKI 372
Query: 500 THKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQ 559
+ K E A + +E + Q E + EE+ + + E E+ EK+ ++++
Sbjct: 373 REQEKRQEQ-------EAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEE 425
Query: 560 EAALELEELKKK----REERRKVLEEEEQRRKQEEADRKLREEEEKRRLKE----EIERR 611
E + E+++++ RE+ +K+ E+EE+ R+QEE ++E+EEK +E E E +
Sbjct: 426 EMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEE---MMQEQEEKMGEQEGKMCEQEAK 482
Query: 612 RAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQK 659
E EK ++ E +KK + KI E+ E + + +K
Sbjct: 483 MQEQEEKMRRQEEKIREQEKK------IREQEEKIREQEEMMQEQEEK 524
Score = 46.2 bits (108), Expect = 1e-04
Identities = 39/190 (20%), Positives = 91/190 (47%), Gaps = 22/190 (11%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDD--DEEEAARERRRRARQERLRQKQEEESLGQVT 63
R +E Q++EE E E +++ ++ ++EE R + + R++ + +++EE + +
Sbjct: 400 REQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQE 459
Query: 64 DQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDP 123
+ ++ + + ++E K +++ +E + RE+ ++ R QE R++E
Sbjct: 460 EMMQ-EQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQE--- 515
Query: 124 TITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEEN 183
MQ E + E+EEK ++E+ + E+ E + + Q+ R+ E
Sbjct: 516 -----------EMMQEQ--EEKMWEQEEKMCEQEEKMQ-EQEEKMRR--QEEKMREQEVR 559
Query: 184 KKEDKEKEEE 193
++ +EK +E
Sbjct: 560 LRQQEEKMQE 569
Score = 33.5 bits (75), Expect = 0.79
Identities = 18/116 (15%), Positives = 52/116 (44%), Gaps = 1/116 (0%)
Query: 2 DDFERRRELRRQKREEM-RLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLG 60
+ + E+ +++ E+M E + + ++EE R + + R++ + +++EE +
Sbjct: 453 EKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIR 512
Query: 61 QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALE 116
+ + ++ + EE E +++ E R +E R ++ +E ++
Sbjct: 513 EQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEKMQ 568
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 141 bits (355), Expect = 3e-33
Identities = 122/454 (26%), Positives = 214/454 (47%), Gaps = 52/454 (11%)
Query: 2 DDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQ 61
DD ER R+ R++R E R + ER R + E R R+R +ER R +++E +
Sbjct: 52 DDRERNRQKERERRREKR-QTERET-DRKRERRREKDRHRKRDRHRERQRDREKERE--R 107
Query: 62 VTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEF 121
TD+ E + Q K T+ EG + + +RE RQ+ ++ ERQ +
Sbjct: 108 QTDR-ERDRQREKERNRQKERERETEREG-ERGRDRQTDGQRERERQRDAEKERERQTD- 164
Query: 122 DPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAE 181
R Q T N E+ E+ ++RQER E E + K + R +E
Sbjct: 165 -------------RERQRQTERNRQKER-EREKNRQER---RERERQREKENKTEDRHSE 207
Query: 182 ENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQE 241
++ ++E+E E E + KR + E ++ TE + E E ++
Sbjct: 208 RGRERERERETETETERKRQTDRERD-----RQRKTERERE-----------KQAERERA 251
Query: 242 EEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKA 301
ERE D+ E+ + D++R + ER R +R+R + E+D++ ER R E+
Sbjct: 252 SERETERDKERERERDRDRDRDRRQKERERQTDRKRQR-RTERDRE--TERKRERQRERE 308
Query: 302 AAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEE--RQRI 359
+ER R+ ERER RE E++ ER R KE E++ + + +E ++ E RQ
Sbjct: 309 RERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAE 368
Query: 360 KEEEKRAAEERQRARAEEE---EKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGK 416
+E E+ +RQ AR EE ++ + +++R +Q E+ + +ET+ + E+ E+ E +
Sbjct: 369 RERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQRER-EKDRESE 427
Query: 417 WVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREK 450
E+ + +K + +++ E+ T QA R++
Sbjct: 428 RGRERGREREKQKG---RERDRERQTDRQAGRQR 458
Score = 136 bits (342), Expect = 9e-32
Identities = 103/433 (23%), Positives = 208/433 (48%), Gaps = 23/433 (5%)
Query: 195 EEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEIS-- 252
+E P+R +G+ + +++ Q+E K + K+E RE+
Sbjct: 34 QESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDR 93
Query: 253 HHEKMEEEDKER---AEAERARLEAEERERIK-AEQDKKIADERAR------IEAEEKAA 302
H E+ + +KER + ER R +ER R K E++ + ER R E+
Sbjct: 94 HRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQR 153
Query: 303 AQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKE---EEKRAAEERQRI 359
E+ER +RER R+ E+ +ER+R K ++R ERQR KE E++ + R+R
Sbjct: 154 DAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERE 213
Query: 360 KEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVN 419
+E E ER+R E ++ + E++R KQ E ++ + +ET+ E+ E++ +
Sbjct: 214 RERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKER-ERERDRDRDR 272
Query: 420 EKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVK 479
+++ +E + QT +++ E+ + + KRE+ +E + ++ ++ + ++++E + + +
Sbjct: 273 DRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQRE 332
Query: 480 SFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEEL 539
+ DR+K + + E + + T R G R + +E E ++ + EE
Sbjct: 333 TERDREKERERKRKRQTEMDRERNRQT----GREGRRQAERERERERERDRQSAREREER 388
Query: 540 RRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEE 599
R R +E E+ +K ++ E E+ +++ ++R E + R +E +K RE +
Sbjct: 389 ERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRE---SERGRERGREREKQKGRERD 445
Query: 600 EKRRLKEEIERRR 612
+R+ + R+R
Sbjct: 446 RERQTDRQAGRQR 458
Score = 133 bits (335), Expect = 6e-31
Identities = 104/401 (25%), Positives = 191/401 (47%), Gaps = 24/401 (5%)
Query: 234 SSEEPK-----QEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKI 288
S E P+ Q + G D + +K E +E+ + ER ER R K K
Sbjct: 33 SQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRK-- 90
Query: 289 ADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQ----R 344
R R ++ +ERER+ ER+R RE+E+ +ER+R E E +RQ R
Sbjct: 91 ---RDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQR 147
Query: 345 IKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKI 404
+E ++ A +ER+R + E++ ER R + E EK + E ++R +Q E++
Sbjct: 148 ERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSE 207
Query: 405 KGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIK 464
+G + E++ E + E+K Q D+ + +++ E+ + QA+RE+ E + KE +
Sbjct: 208 RGRERERERETETETERKRQTDRERD---RQRKTEREREKQAERERASERETERDKERER 264
Query: 465 DEKIKKDKEPKEEVKSFM-DRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKE 523
+ +D++ +++ + DRK+ + + E + + E R R +E
Sbjct: 265 ERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERE 324
Query: 524 AEGAPQ--VEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELE-ELKKKREERRKVLE 580
E Q E + E R+R+ +TE + E+ +Q +E + E E +++RE R+
Sbjct: 325 RERERQRETERDREKERERKRKRQTEMDR-ERNRQTGREGRRQAERERERERERDRQSAR 383
Query: 581 EEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQK 621
E E+R + + DR ++E E++ K+ +R E +R+K
Sbjct: 384 EREERERDRDRDR--QKERERQTEKDRDGQRETEKQREREK 422
Score = 131 bits (330), Expect = 2e-30
Identities = 110/451 (24%), Positives = 202/451 (44%), Gaps = 45/451 (9%)
Query: 41 RRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERL 100
RRR QE R++ LGQ + + + +E + Q E + + +R
Sbjct: 28 RRRPGSQESPRRR----GLGQAHKDADGDDRERNRQKERERRREKRQTERETDR---KRE 80
Query: 101 ARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERY 160
RRE+ R ++ ERQ++ + R Q D + EKE + +ER
Sbjct: 81 RRREKDRHRKRDRHRERQRDREK----------ERERQTDRERDRQREKERNRQKERER- 129
Query: 161 EIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQ 220
E E + Q + R+ E + +KE+E + + + +R + E+ + +
Sbjct: 130 ETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQT-----------ERNRQKE 178
Query: 221 EETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKER---AEAERARLEAEER 277
E KN Q E +Q E+ + D H E+ E ++ER E ER R ER
Sbjct: 179 RERE----KNRQERRERERQREKENKTEDR--HSERGRERERERETETETERKRQTDRER 232
Query: 278 ER-IKAEQDKKIADERARIEAEEKAAAQERERREAEERER-MREEEKRAAEERQRIKEEE 335
+R K E++++ ER R E +ERER +R+R R++E+ +R+R + E
Sbjct: 233 DRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTE 292
Query: 336 KRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEK 395
+ ER+R ++ E+ ER R +E E+ ER+R R E ++ K E+KR +Q E
Sbjct: 293 RDRETERKRERQRERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMD 352
Query: 396 KHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDK 455
+ ++T +G + ++ E++ + D+ +++ ++ Q +RE+ E
Sbjct: 353 RERNRQTGREGRRQAER-----ERERERERDRQSAREREERERDRDRDRQKERERQTEKD 407
Query: 456 PTFKKEEIKDEKIKKDKEPKEEVKSFMDRKK 486
++E K + +KD+E + + +R+K
Sbjct: 408 RDGQRETEKQREREKDRESERGRERGREREK 438
Score = 129 bits (325), Expect = 8e-30
Identities = 106/398 (26%), Positives = 188/398 (47%), Gaps = 29/398 (7%)
Query: 5 ERRRELRRQKREEMRLEAERIAY---QRNDDDEEEAARERRRRARQERLRQKQEEESLG- 60
ERRRE R ++ + E +R +R D E + RE+ R ++ER R+ + E G
Sbjct: 80 ERRREKDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGR 139
Query: 61 --QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQ 118
Q Q E Q E + T Q + ER ++E R+K QE ER+
Sbjct: 140 DRQTDGQRERERQRDAEKERERQTDRERQRQ-------TERNRQKEREREKNRQERRERE 192
Query: 119 KEFDPTITDASLSLPSRRMQNDTAENET-TEKEEKSESRQERYEIEETETVTKSYQKNDW 177
++ + + + S R + E ET TE E K ++ +ER +TE + + +
Sbjct: 193 RQREKE--NKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERE- 249
Query: 178 RDAEENKKEDKEKEEEEE---EKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQIS 234
R +E + DKE+E E + ++ +R E Q + + +T +E + +
Sbjct: 250 RASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERER 309
Query: 235 SEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERAR 294
E ++ ERE+ + ++ E D+E+ E ER R E +R E++++ E R
Sbjct: 310 ERERNRKRERERERERERERQRETERDREK-ERERKRKRQTEMDR---ERNRQTGREGRR 365
Query: 295 IEAEEKAAAQERERREA---EERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKR 351
E+ +ER+R+ A EERER R+ +++ ERQ K+ + + E+QR +E+++
Sbjct: 366 QAERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRE 425
Query: 352 AAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRN 389
+ R+R +E EK+ ER R R + + + ++KR+
Sbjct: 426 SERGRERGREREKQKGRERDRERQTDRQAGR--QRKRS 461
Score = 129 bits (323), Expect = 1e-29
Identities = 114/514 (22%), Positives = 222/514 (43%), Gaps = 27/514 (5%)
Query: 238 PKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEA 297
P R GS E + + K+ +R R +ERER + ++ + +R R
Sbjct: 23 PLDFSRRRPGSQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERR 82
Query: 298 EEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAE--- 354
EK ++R+R +R+R +E E++ ER R +E+E+ +ER+R E E
Sbjct: 83 REKDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQ 142
Query: 355 -------ERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGE 407
ERQR E+E+ +R+R R E + K E+++N+Q ++ +E K
Sbjct: 143 TDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQRE---KEN 199
Query: 408 KVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEK 467
K E + + ++ +E + +T ++ E+ + + +RE+ ++ ++E + +
Sbjct: 200 KTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQ----AERERASERE 255
Query: 468 IKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGA 527
++DKE + E DR + E + Q + + T R R +E E
Sbjct: 256 TERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRET-ERKRERQRERERERERN 314
Query: 528 PQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRK 587
+ E + E R R+ ETE + EK ++++++ E++ + ++ R + E +R +
Sbjct: 315 RKRERERERERERERQRETERDR-EKERERKRKRQTEMDRERNRQTGREGRRQAERERER 373
Query: 588 QEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIE 647
+ E DR+ E E+R + + +R R + E++ + DG + +K + + S
Sbjct: 374 ERERDRQSAREREER--ERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRES----- 426
Query: 648 ERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAE 707
ER + +K G + + + + ++ T + + SD P
Sbjct: 427 ERGRERGREREKQKGRERDRERQTDRQAGRQRKRSTLYVNPPPRTARSGVVQSDPNRPTR 486
Query: 708 GVRNIKSMWEKGNVFSSPTAAGTPNKETAGLKVG 741
G+R KS E S+ G P K + G G
Sbjct: 487 GIR-WKSSPEDPKAASTRFPWGRPAKASRGRVAG 519
Score = 121 bits (304), Expect = 2e-27
Identities = 93/402 (23%), Positives = 192/402 (47%), Gaps = 18/402 (4%)
Query: 229 KNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIK-AEQDKK 287
K+ E +++ERE+ ++ + + + + R E +R R RER + E++++
Sbjct: 47 KDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERE 106
Query: 288 IADERARIEAEEKAAAQERERREAEERE----RMREEEKRAAEERQRIKEEEKRAAEERQ 343
+R R EK +++ER ERE R R+ + + ERQR E+E+ +R+
Sbjct: 107 RQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRE 166
Query: 344 RIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETK 403
R ++ E+ +ER+R K ++R ERQR E+E K + +R ++ E ++ ET+
Sbjct: 167 RQRQTERNRQKEREREKNRQERRERERQR---EKENKTEDRHSERGRERERERETETETE 223
Query: 404 IKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEI 463
K + ++ + ++ ++ + + A ++ +K + + R++ D+ ++E
Sbjct: 224 RKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDR-DRDRRQKERERQ 282
Query: 464 KDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKE 523
D K ++ E E + +R++ + +N + + + E R R +E
Sbjct: 283 TDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQRETERDREKERE 342
Query: 524 AEGAPQVEAGKRLEELRRRRGETESE-EFEKLKQKQQEAALELEELKKKREERRKVLEEE 582
+ Q E + R G ++E E E+ +++ +++A E EE ++ R+ R +
Sbjct: 343 RKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREERERDRDRDR-----Q 397
Query: 583 EQRRKQEEADRKLREEEEKRRLKE---EIERRRAEAAEKRQK 621
++R +Q E DR + E EK+R +E E ER R E+ ++
Sbjct: 398 KERERQTEKDRDGQRETEKQREREKDRESERGRERGREREKQ 439
Score = 102 bits (254), Expect = 1e-21
Identities = 86/350 (24%), Positives = 157/350 (44%), Gaps = 41/350 (11%)
Query: 3 DFERRRELRRQKREEMRLEAERIAYQRNDDD-EEEAARERRRRARQERLRQKQEEESLGQ 61
D +R RE +R +E + +R ++ + + ++E RE+ R+ R+ER RQ+++E
Sbjct: 144 DGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKT-- 201
Query: 62 VTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEF 121
+ + + + E +T T + D +R RE +Q + A ER+ E
Sbjct: 202 ---EDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETER 258
Query: 122 DPTIT-------DASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQK 174
D D R Q D TE++ ++E ++ER Q+
Sbjct: 259 DKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRER-------------QR 305
Query: 175 NDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQIS 234
R+ E N+K ++E+E E E + +R + + + +E+ + + +T + +N Q
Sbjct: 306 ERERERERNRKRERERERERERERQRETERDRE-----KERERKRKRQTEMDRERNRQTG 360
Query: 235 SEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERAR 294
E +Q E + E E E++ER +R R +ERER + E+D+ E +
Sbjct: 361 REGRRQAERERERERERDRQSAREREERER---DRDRDRQKERER-QTEKDRDGQRETEK 416
Query: 295 IEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQR 344
EK +RE ER R RE++K ER R ++ +++A +R+R
Sbjct: 417 QREREK----DRESERGRERGREREKQK--GRERDRERQTDRQAGRQRKR 460
Score = 30.4 bits (67), Expect = 6.7
Identities = 17/56 (30%), Positives = 30/56 (53%), Gaps = 1/56 (1%)
Query: 3 DFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEES 58
D + +RE +Q+ E E+ER +R + E++ RER R + +R +Q + S
Sbjct: 407 DRDGQRETEKQREREKDRESER-GRERGREREKQKGRERDRERQTDRQAGRQRKRS 461
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 137 bits (346), Expect = 3e-32
Identities = 101/420 (24%), Positives = 227/420 (54%), Gaps = 23/420 (5%)
Query: 212 VEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERAR 271
++EK E QEE ++ + +I + + + E + ++ E++ + E E
Sbjct: 9 LKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVREQEGQV 68
Query: 272 LEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRI 331
E E + R EQ+ ++ ++ ++ E++ +E+E + E+ ++RE+E + E+ ++
Sbjct: 69 REQEGQVR---EQEGQVREQEGQVR-EQEGQVREQEGQVREQEGQVREQEGQVREQEGQV 124
Query: 332 KEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEE----EEKAKVEEQK 387
+E+E + E+ +++E+E + E+ +++E+E + E+ + R +E E++ +V EQ+
Sbjct: 125 REQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQE 184
Query: 388 RNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTK---V 444
+ +E + QE ++ GE+ EQ E + +K+ ++ Q ++KQ E+ G + V
Sbjct: 185 GQVREQEGQMGEQEGQM-GEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQV 243
Query: 445 QAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLK 504
Q + E++Q+ + +K+E E++++ +E E + M ++K TE + Q GE +++
Sbjct: 244 QKQEEQVQKQEEQMRKQE---EQMREQEEQMREQEEQMLKQKEQTEQEEQTGE-QEEQMR 299
Query: 505 HTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALE 564
E R + +E + + GK+ E++ ++ + ++ + KQ++Q E
Sbjct: 300 EQEEQM-REQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQE 358
Query: 565 LEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPE 624
E+++K+ E+ RK +EEQ RKQEE RK +EE+ R+ +E++ ++ + E++++M E
Sbjct: 359 -EQMQKQEEQVRK---QEEQMRKQEEQMRK--QEEQMRKQEEQMGEQKEQMGEQKEQMRE 412
Score = 134 bits (338), Expect = 3e-31
Identities = 99/431 (22%), Positives = 222/431 (51%), Gaps = 36/431 (8%)
Query: 14 KREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNS 73
K + +LE ++I + E+ + R + Q R ++ Q E GQV +Q +
Sbjct: 35 KELKRKLETDKIPLPQEGQVREQEGQVREQEG-QVREQEGQVREQEGQVREQ-----EGQ 88
Query: 74 VPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLP 133
V ++E + QV + + RE+ Q R QE R++E
Sbjct: 89 VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQV---------- 138
Query: 134 SRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEE 193
R + E E +E++ + R++ ++ E E + ++ + ++E + +E+E
Sbjct: 139 -REQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE------QEGQVREQEGQVREQE 191
Query: 194 EEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISH 253
+ + G +GE + ++ +E+ + QEE + + + E+ ++EE+ Q +E
Sbjct: 192 GQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEE--- 248
Query: 254 HEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEE 313
+ ++E++ R + E+ R E EE+ R EQ++++ ++ + E EE+ QE + RE E
Sbjct: 249 -QVQKQEEQMRKQEEQMR-EQEEQMR---EQEEQMLKQKEQTEQEEQTGEQEEQMREQE- 302
Query: 314 RERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRA 373
E+MRE+E++ E+ ++++E+E++ ++ +++ E++++ E+++++ ++E++ E+ ++
Sbjct: 303 -EQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQM 361
Query: 374 RAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIE-GKWVNEKKAQEDKL--QT 430
+ +EE+ K EEQ R ++ + +K Q K + + EQK + G+ + + QE+++ Q
Sbjct: 362 QKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQK 421
Query: 431 AVLKKQGEEKG 441
++KQ E G
Sbjct: 422 EQMRKQEEHMG 432
Score = 124 bits (312), Expect = 3e-28
Identities = 92/469 (19%), Positives = 233/469 (49%), Gaps = 42/469 (8%)
Query: 123 PTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEE 182
P IT+ L + +Q + ET + E + ++ + ++E + + ++ +
Sbjct: 2 PRITNEELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQV 61
Query: 183 NKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEE 242
++E + +E+E + + + G + E + +V +E QE V + GQ+ +E + E
Sbjct: 62 REQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQV--REQEGQVREQEGQVRE 119
Query: 243 EREQGSDEISHHEKMEEEDKER-AEAERARLEAEERERIKAEQDKKIADERARIEAEEKA 301
+ Q ++ + E + +E+ + + E+E EQ+ ++ ++ ++ E++
Sbjct: 120 QEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVR-EQEG 178
Query: 302 AAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKE 361
+E+E + E+ +M E+E + E+ +++ E+E++ ++ +++ E+E++ ++ +++ E
Sbjct: 179 QVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGE 238
Query: 362 EEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEK 421
+E++ ++ ++ + +EE+ K EEQ R + EE+ +E +K +K
Sbjct: 239 QEEQVQKQEEQVQKQEEQMRKQEEQMREQ--EEQMREQEEQMLK--------------QK 282
Query: 422 KAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSF 481
+ E + QT ++Q E+ +++ + E+++E + +++E ++ K++++ E+ +
Sbjct: 283 EQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQE--EQMGKQEEQMWEQKEQM 340
Query: 482 MDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRR 541
++K+ + + Q GE K E V +E + Q E ++ EE R
Sbjct: 341 WEQKEQMWKQEEQMGEQEEQMQKQEE----------QVRKQEEQMRKQEEQMRKQEEQMR 390
Query: 542 RRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEE 590
++ E E+ E++ +++++ RE+ ++ E++EQ RKQEE
Sbjct: 391 KQEEQMGEQKEQMGEQKEQ----------MREQEEQMGEQKEQMRKQEE 429
Score = 124 bits (310), Expect = 4e-28
Identities = 103/478 (21%), Positives = 246/478 (51%), Gaps = 54/478 (11%)
Query: 148 EKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEE-EKPKRGSIGEN 206
E +EK+ QE ++ ETE + + + KE K K E ++ P+ G + E
Sbjct: 8 ELKEKNAELQEELQLVETEK----------SEIQLHIKELKRKLETDKIPLPQEGQVREQ 57
Query: 207 QVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAE 266
+ +V +E QE V + GQ+ +E + E+ Q ++ + E+E + R +
Sbjct: 58 EGQVREQEGQVREQEGQV--REQEGQVREQEGQVREQEGQVREQ--EGQVREQEGQVREQ 113
Query: 267 AERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAE 326
+ R E+E EQ+ ++ ++ ++ E++ +E+E + E+ ++RE+E + E
Sbjct: 114 EGQVR----EQEGQVREQEGQVREQEGQVR-EQEGQVREQEGQVREQEGQVREQEGQVRE 168
Query: 327 ERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQ 386
+ +++E+E + E+ +++E+E + E+ ++ E+E++ E+ ++ + +EE+ + EEQ
Sbjct: 169 QEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQ 228
Query: 387 KRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQA 446
R + EE+ +E K E+ QK E + + QE++++ ++Q E+ ++
Sbjct: 229 MRKQ--EEQMGEQEEQVQKQEEQVQKQE----EQMRKQEEQMREQ--EEQMREQEEQMLK 280
Query: 447 KREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHT 506
++E+ ++++ T ++EE E+ ++ +E +E+++ ++++ E + Q G+ +
Sbjct: 281 QKEQTEQEEQTGEQEEQMREQEEQMREQEEQMR---EQEEQMREQEEQMGKQEEQMWEQK 337
Query: 507 ENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELE 566
E + + KE + + G++ E+++++ + +E + KQ++Q
Sbjct: 338 EQMWEQ---------KEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQ------- 381
Query: 567 ELKKKREERRKVLEEEEQRRKQE---EADRKLREEEEKR-RLKEEIERRRAEAAEKRQ 620
++K+ E+ RK +EE+ ++E E ++RE+EE+ KE++ ++ E+++
Sbjct: 382 -MRKQEEQMRK--QEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQEEHMGEQKE 436
Score = 120 bits (301), Expect = 5e-27
Identities = 111/469 (23%), Positives = 233/469 (49%), Gaps = 45/469 (9%)
Query: 44 RARQERLRQKQEE--ESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLA 101
R E L++K E E L Q+ + + Q + + + K T + + + E
Sbjct: 3 RITNEELKEKNAELQEEL-QLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQV 61
Query: 102 RREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYE 161
R +E Q R QE R++E + + R + E E +E++ + R++ +
Sbjct: 62 REQEG-QVREQEGQVREQEGQVREQEGQV----REQEGQVREQEGQVREQEGQVREQEGQ 116
Query: 162 IEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQE 221
+ E E + ++ + ++E + +E+E + + + G + E + +V +E QE
Sbjct: 117 VREQEGQVRE------QEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQE 170
Query: 222 ETVVMSLKNGQISSEEPK-QEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERI 280
V + GQ+ +E + +E+E + G E +M E++++ E E + EE+
Sbjct: 171 GQV--REQEGQVREQEGQVREQEGQMGEQE----GQMGEQEEQMGEQEEQMQKQEEQMGE 224
Query: 281 KAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAE 340
+ EQ +K ++ E EE+ QE + ++ EE+ R +EE+ R EE+ R +EE+ +
Sbjct: 225 QEEQMRKQEEQMG--EQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQK 282
Query: 341 ERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQ 400
E+ E+E++ E+ ++++E+E++ E+ ++ R +EE+ + EQ+ +Q+ +++ M
Sbjct: 283 EQT---EQEEQTGEQEEQMREQEEQMREQEEQMREQEEQ---MREQE--EQMGKQEEQMW 334
Query: 401 ETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKK 460
E K E++ ++ E W E++ E + Q ++KQ E+ V+ + E++++ + +K
Sbjct: 335 EQK---EQMWEQKEQMWKQEEQMGEQEEQ---MQKQEEQ----VRKQEEQMRKQEEQMRK 384
Query: 461 EEIKDEKIKKDKEPKEEVKSFM-DRKKGFTEVKSQNGEFMTHKLKHTEN 508
+E E+++K +E E K M ++K+ E + Q GE K E+
Sbjct: 385 QE---EQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQEEH 430
Score = 119 bits (297), Expect = 1e-26
Identities = 92/419 (21%), Positives = 209/419 (49%), Gaps = 44/419 (10%)
Query: 12 RQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQ 71
R++ ++R + ++ Q E+E + R + Q R ++ Q E GQV +Q +
Sbjct: 55 REQEGQVREQEGQVREQEGQVREQEG--QVREQEGQVREQEGQVREQEGQVREQ-----E 107
Query: 72 NSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLS 131
V ++E + QV + + RE+ Q R QE R++E + +
Sbjct: 108 GQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQV- 166
Query: 132 LPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKE 191
R + E E +E++ + R++ ++ E E ++ E+ +K++++
Sbjct: 167 ---REQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMG 223
Query: 192 EEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEI 251
E+EE+ K+ + ++ +E+ + QEE V KQEE+ + +++
Sbjct: 224 EQEEQMRKQ------EEQMGEQEEQVQKQEEQV-------------QKQEEQMRKQEEQM 264
Query: 252 SHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREA 311
E+ E +E+ ++ + E EE+ + EQ + E EE+ QE + RE
Sbjct: 265 REQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMR---------EQEEQMREQEEQMREQ 315
Query: 312 EERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQ 371
E E+MRE+E++ ++ +++ E++++ E+++++ ++E++ E+ ++++++E++ ++ +
Sbjct: 316 E--EQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEE 373
Query: 372 RARAEEEEKAKVEEQ--KRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKL 428
+ R +EE+ K EEQ K+ +Q+ E+K M E K + + E+++ G+ + + QE+ +
Sbjct: 374 QMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQM-GEQKEQMRKQEEHM 431
Score = 112 bits (281), Expect = 1e-24
Identities = 80/377 (21%), Positives = 192/377 (50%), Gaps = 20/377 (5%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEE----ESLG 60
E+ ++R Q+ + E + + ++E RE+ + R++ + +++E E G
Sbjct: 70 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 129
Query: 61 QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE 120
QV +Q + V ++E + QV + + RE+ Q R QE R++E
Sbjct: 130 QVREQ-----EGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQE 184
Query: 121 FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA 180
+ + + + Q E + E+EE+ + ++E+ E+ E + K ++ ++
Sbjct: 185 GQ--VREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMG-EQEEQMRKQEEQMGEQEE 241
Query: 181 EENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQ 240
+ K+E++ +++EE+ + + + E + ++ +E+ Q+E + G+ + +Q
Sbjct: 242 QVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQ 301
Query: 241 EEE-REQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEE 299
EE+ REQ E+M E++++ + E E ++E++ ++++ E E EE
Sbjct: 302 EEQMREQEEQMREQEEQMREQEEQMGKQEEQMWE--QKEQMWEQKEQMWKQEEQMGEQEE 359
Query: 300 KAAAQERERREAEERERMREEEKRAAEERQRIKEEE-----KRAAEERQRIKEEEKRAAE 354
+ QE + R+ EE+ R +EE+ R EE+ R +EE+ ++ E++++++E+E++ E
Sbjct: 360 QMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGE 419
Query: 355 ERQRIKEEEKRAAEERQ 371
++++++++E+ E+++
Sbjct: 420 QKEQMRKQEEHMGEQKE 436
Score = 102 bits (255), Expect = 1e-21
Identities = 80/363 (22%), Positives = 191/363 (52%), Gaps = 38/363 (10%)
Query: 259 EEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMR 318
EE KE+ + L+ E E K+E I + + ++E ++ QE + RE E + +R
Sbjct: 7 EELKEKNAELQEELQLVETE--KSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQ--VR 62
Query: 319 EEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEE 378
E+E + E+ +++E+E + E+ +++E+E + E+ +++E+E + E+ + R +E
Sbjct: 63 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 122
Query: 379 EKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGE 438
+ + E Q R ++ + ++ Q + +G+ EQ EG+ V E++ Q + + V +++G+
Sbjct: 123 QVREQEGQVREQEGQVREQEGQVREQEGQVREQ--EGQ-VREQEGQVREQEGQVREQEGQ 179
Query: 439 EKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEF 498
+ + Q + ++ Q + + E +++ +++++ +++ + ++++ + + Q GE
Sbjct: 180 VREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGE- 238
Query: 499 MTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQ 558
+E + Q E ++ EE R++ E E+ E++++++
Sbjct: 239 -----------------------QEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQE 275
Query: 559 QEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEK 618
++ + K++ E+ + E+EEQ R+QEE ++RE+EE+ R +EE R + E K
Sbjct: 276 EQMLKQ----KEQTEQEEQTGEQEEQMREQEE---QMREQEEQMREQEEQMREQEEQMGK 328
Query: 619 RQK 621
+++
Sbjct: 329 QEE 331
Score = 61.2 bits (147), Expect = 4e-09
Identities = 51/266 (19%), Positives = 114/266 (42%), Gaps = 43/266 (16%)
Query: 2 DDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQ 61
+ +++ E ++ E+MR + E++ Q EE+ ++ + +QE +KQEE+ Q
Sbjct: 213 EQMQKQEEQMGEQEEQMRKQEEQMGEQ-----EEQVQKQEEQVQKQEEQMRKQEEQMREQ 267
Query: 62 VTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEF 121
+ + ++E + Q E +++ E R +E + + +E + Q+E
Sbjct: 268 ---------EEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEE- 317
Query: 122 DPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAE 181
+ E ++E+ E +++ +E +E W+ E
Sbjct: 318 ---------------QMREQEEQMGKQEEQMWEQKEQMWEQKE----------QMWKQEE 352
Query: 182 ENKKEDKEKEEEEEEKPKRGSIGENQVEVM-VEEKTTESQEETVVMSLKNGQISSEEPKQ 240
+ +++++ +++EE+ K+ Q E M +E+ QEE M + Q+ ++ +
Sbjct: 353 QMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQ--MGEQKEQMGEQKEQM 410
Query: 241 EEEREQGSDEISHHEKMEEEDKERAE 266
E+ EQ ++ K EE E+ E
Sbjct: 411 REQEEQMGEQKEQMRKQEEHMGEQKE 436
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 133 bits (334), Expect = 7e-31
Identities = 178/859 (20%), Positives = 370/859 (43%), Gaps = 137/859 (15%)
Query: 4 FERRRELRRQKREEMRLEAERIAYQRNDDDE--EEAARERRRRARQ-------------- 47
F ++ E Q+ E++ EAE++A +R + E+ ARE + A++
Sbjct: 1637 FAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQK 1696
Query: 48 -ERLRQKQE-----EESLGQVTDQVEVNAQN------SVPDEEAKTTTTNTQVEGDDEA- 94
E L Q+++ E+ L Q +++E + + + EE K ++ ++EA
Sbjct: 1697 VEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEAL 1756
Query: 95 AFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSE 154
A+ EE + + +E L ++KE + +P + + EK+ K
Sbjct: 1757 AWQREKLSEEETKLAQEEELLIQEKE---KLAQHKEKMPEEEERLGRKREQLIEKKMKLA 1813
Query: 155 SRQERYEIEETETVTKS----YQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEV 210
++ER+ I E +TK+ YQK + ++N ++KEK + +E +
Sbjct: 1814 QKRERW-INSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENL-----------L 1861
Query: 211 MVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDE-ISHHEKMEEEDKERAEAER 269
+E+ T S+++ V + K G + + EE+ Q + I EK+ E +K+ + E
Sbjct: 1862 YNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVED 1921
Query: 270 ARLEAEER---ERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAE 326
+ + +E+ E++K +K + + R+ E A +E+ E +R+ EE+ R E
Sbjct: 1922 SLAKKQEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNL--EMKRLAEEKMRLVE 1979
Query: 327 ERQRIKEEEKRAAEERQRIKE------EEKRAAEERQRIKEEEKRAAEERQRARAEEE-- 378
++ + + E ++++ + E K + EE+ + E+ A EE + A+ + E
Sbjct: 1980 GKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFT 2039
Query: 379 --EKAKVEEQKR----NKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAV 432
++ V+ Q++ +++L +K+ ++ + K K+ + ++ +E+K +++++
Sbjct: 2040 RGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTK 2099
Query: 433 LKKQGEEKGTKVQAKREKLQEDKPTF---KKEEIKDEK--IKKDKEPKEEVKSFMDRKKG 487
+K+ K ++ ++ KL + F + E KDEK +K ++ +++ +++++
Sbjct: 2100 MKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEK 2159
Query: 488 FTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGE-- 545
TE +S+ KH+E +D +E G + E L+ R+R E
Sbjct: 2160 MTEEESKLAR------KHSE---------VILDDEEEGGIEEEEVIPFLKRRWRKRKEAK 2204
Query: 546 ----------TESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKL 595
++ +E E + +E L+EL+K+ + EE E+ ++EE ++
Sbjct: 2205 RGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREE--EEV 2262
Query: 596 REEEEKRRLKEEIERRRA--EAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFL 653
REEEE+R+ +EE E ++ E EK++K E + ++ + F K + EE E L
Sbjct: 2263 REEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEK-EEIMSEEETESL 2321
Query: 654 NKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIK 713
+ ++ + +I + +Q+ + KS + + S L
Sbjct: 2322 SDEEEEEESCSLEEEVDREKEILKKEKQFKLQEQRRKSLRGRERVLSIL----------- 2370
Query: 714 SMWEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVS 773
G P+ + +++GV + L T K P P V
Sbjct: 2371 --------------RGVPHGKGRAIRLGVLKSPLKKLMSTALEMKEKTPVP-------VP 2409
Query: 774 SKRNLWEKQSVDKVTSPTK 792
K+ WE + V P K
Sbjct: 2410 EKQISWEDKKATVVEIPRK 2428
Score = 127 bits (320), Expect = 3e-29
Identities = 146/715 (20%), Positives = 322/715 (45%), Gaps = 82/715 (11%)
Query: 15 REEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSV 74
RE E + QR+ +E + AR R+RAR E+ ++ QEE L Q +++ + +
Sbjct: 1552 REGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEK-KRAQEERKLAQEEEKL-AQEERQL 1609
Query: 75 PDEEAKTTTTNTQVEGDD------EAAFL---ERLARREERRQKRLQEALERQKEFDPTI 125
EE K ++ DD E F E LA+R E+ + ++ +++K+
Sbjct: 1610 AQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKL---- 1665
Query: 126 TDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKK 185
+++ + E E K+ + + ++ E + + Q DW++ E ++
Sbjct: 1666 --------AKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQE 1717
Query: 186 EDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEERE 245
++ + + EE K + + + +++ E+K +EE ++ + ++S EE K +E E
Sbjct: 1718 LEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEE--ALAWQREKLSEEETKLAQEEE 1775
Query: 246 ---QGSDEISHHEKMEEEDKERAEAERARL------EAEERER-----IKAEQDKKIADE 291
Q ++++ H++ E++ER +R +L A++RER + ++K I +
Sbjct: 1776 LLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQ 1835
Query: 292 RARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKR 351
+ + E+K AQE+E+ + + +E+ ++Q ++ + K + + EEK
Sbjct: 1836 KKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKL 1895
Query: 352 AAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQ 411
E+ IK++EK A E++ + E+ K E+ + E+ K A+++ ++G+K
Sbjct: 1896 TQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQ----EKMKLALEKAMVQGKK--- 1948
Query: 412 KIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKE----EIKDEK 467
++ G+ A+E+K +K+ EEK V+ K + + P ++ +++ E
Sbjct: 1949 RLRGEL---DIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQEL 2005
Query: 468 IKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRAS---VDTKEA 524
++ +E++ DR E + G+ + + R +AS + +E+
Sbjct: 2006 FERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRES 2065
Query: 525 EGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEE--- 581
+ K L+ L++ + E++K + + AL ++E + E+ + ++E
Sbjct: 2066 LSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWDF 2125
Query: 582 EEQRRKQEEADRKLREEEEK-----RRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKC 636
E+R + + ++KL ++ K RR+ + E+ E ++ +K E L D+++
Sbjct: 2126 SEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEE---- 2181
Query: 637 FTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKS 691
++ EE FL + +K K + D E+++S ++ +S
Sbjct: 2182 -----GGIEEEEVIPFLKRRWRKRKEAK---------RGDKPKEKFSSQVDEVES 2222
Score = 124 bits (312), Expect = 3e-28
Identities = 153/721 (21%), Positives = 319/721 (44%), Gaps = 136/721 (18%)
Query: 1 MDDFERRRELRRQKREEMRLEAERIAYQRND-DDEEEAARERRRRARQERLRQKQEEESL 59
+++ E E K EE+ E ++ ++ +EEEA +R + +E + QEEE L
Sbjct: 1718 LEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELL 1777
Query: 60 GQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQK 119
Q +++ + + +P+EE ERL R+ E
Sbjct: 1778 IQEKEKLAQHKEK-MPEEE-------------------ERLGRKRE-------------- 1803
Query: 120 EFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKS----YQKN 175
+ EK+ K ++ER+ I E +TK+ YQK
Sbjct: 1804 -------------------------QLIEKKMKLAQKRERW-INSMEELTKNKMILYQKK 1837
Query: 176 DWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISS 235
+ ++N ++KEK + +E + +E+ T S+++ V + K G +
Sbjct: 1838 NLAQEKKNLAQEKEKLAQRKEN-----------LLYNKERLTHSKKQLVQVKNKLGMFNK 1886
Query: 236 EEPKQEEEREQGSDE-ISHHEKMEEEDKERAEAERARLEAEER---ERIKAEQDKKIADE 291
+ EE+ Q + I EK+ E +K+ + E + + +E+ E++K +K +
Sbjct: 1887 ILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQG 1946
Query: 292 RARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKE---- 347
+ R+ E A +E+ E +R+ EE+ R E ++ + + E ++++ +
Sbjct: 1947 KKRLRGELDIAKEEKALN--LEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQE 2004
Query: 348 --EEKRAAEERQRIKEEEKRAAEERQRARAEEE----EKAKVEEQ----KRNKQLEEKKH 397
E K + EE+ + E+ A EE + A+ + E ++ V+ Q K +++L +K+
Sbjct: 2005 LFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRE 2064
Query: 398 AMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPT 457
++ + K K+ + ++ +E+K +++++ +K+ K ++ ++ KL +
Sbjct: 2065 SLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWD 2124
Query: 458 F---KKEEIKDEK--IKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTEN---- 508
F + E KDEK +K ++ +++ +++++ TE +S+ + + E
Sbjct: 2125 FSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGI 2184
Query: 509 ------TFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKL---KQKQQ 559
F + R + K + P+ + +++E+ E SEE E L +KQ+
Sbjct: 2185 EEEEVIPFLKRRWRKRKEAKRGD-KPKEKFSSQVDEVESE--EHFSEEMESLLDELEKQE 2241
Query: 560 EAALELEELKKKREER--RKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAE 617
+ E EE +++ EER +V EEEE+R+++EE + K E+EE+ + K++ E+++ E E
Sbjct: 2242 SLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQE 2301
Query: 618 KRQKMPE----------DGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTH 667
K + E + LSD+++ + S +EE + + ++K K
Sbjct: 2302 KEEVFEEKEEIMSEEETESLSDEEE-------EEESCSLEEEVDREKEILKKEKQFKLQE 2354
Query: 668 Q 668
Q
Sbjct: 2355 Q 2355
Score = 121 bits (303), Expect = 3e-27
Identities = 142/619 (22%), Positives = 263/619 (42%), Gaps = 69/619 (11%)
Query: 40 ERRRRARQERLRQKQE----EESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAA 95
E+R +E+L Q E EE + Q +++ V + + + Q + ++E
Sbjct: 1486 EKRLLQEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVT 1545
Query: 96 FLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETT-EKEEKSE 154
E ++R E ++ Q+ E Q+ A + R + A+ E +EE+
Sbjct: 1546 LEEEVSREGEEKE---QQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKL 1602
Query: 155 SRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVE- 213
+++ER +E + ++Y K D E + E K ++EE +RG + E + +
Sbjct: 1603 AQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEET-LAQRGEKLSQEAEKLAQK 1661
Query: 214 --------EKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERA 265
EK +E+ K ++ + ++ EE Q + EK ++ E
Sbjct: 1662 RKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEEL 1721
Query: 266 EAERARLEAEERERIK-----AEQDKKIADERARIEAEEKAAAQERERREAEERERMREE 320
E + L +E E + E+ KK+A+E E A +RE++ EE
Sbjct: 1722 EWDMEELSWKEEELNQEEGKLVEEKKKLAEE---------------EEALAWQREKLSEE 1766
Query: 321 EKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQR--ARAEEE 378
E + A+E + + +E+++ A+ ++++ EEE+R +R+++ E++ + A++R+R EE
Sbjct: 1767 ETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEEL 1826
Query: 379 EKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKK--- 435
K K+ ++ +EKK+ QE EK+ Q+ E N+++ K Q +K
Sbjct: 1827 TKNKMILYQKKNLAQEKKNLAQEK----EKLAQRKENLLYNKERLTHSKKQLVQVKNKLG 1882
Query: 436 -------QGEEKGTK----VQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDR 484
Q EEK T+ V K+EKL E + K +++D KK ++ +E
Sbjct: 1883 MFNKILAQVEEKLTQEKETVIKKKEKLAETEK--KLVQVEDSLAKKQEKLAQEKMKLALE 1940
Query: 485 KKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRG 544
K K GE K + N + A + EG + G+ E R+R+
Sbjct: 1941 KAMVQGKKRLRGELDIAKEEKALNLEMK--RLAEEKMRLVEGKETLSKGETPETSRQRK- 1997
Query: 545 ETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRL 604
+++Q+ E L LEE E+R +EE E + + E R R + +R
Sbjct: 1998 ------MTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRK 2051
Query: 605 KEEIERRRAEAAEKRQKMP 623
+ R+ + E K P
Sbjct: 2052 LAKASRKLIKKRESLSKEP 2070
Score = 118 bits (296), Expect = 2e-26
Identities = 128/535 (23%), Positives = 251/535 (46%), Gaps = 45/535 (8%)
Query: 98 ERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKS---- 153
E + R EE+ QK+ ++ L ++ I + N T E ++KEEK
Sbjct: 1341 EVMPREEEQAQKKARDMLGLEET--QVILKKGKKVIFLEPGNVTMGKEISKKEEKKTFQK 1398
Query: 154 ESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKP--KRGSIGENQVEVM 211
+Q R +++ V K + E KE+++ EE EE + + + VM
Sbjct: 1399 SPKQGRKAVQKERKVGKIKR--------EMTKEERDMSEEVEEMATLEEKVVKQEGKLVM 1450
Query: 212 VE--------EKTTESQEETVVMSLKNGQISSEE-----PKQEEEREQGSDEISHHEKME 258
+E +K + ++ + K+ + EE ++EE+ Q +++S E+M
Sbjct: 1451 IERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAGEKLSPEEEML 1510
Query: 259 EEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMR 318
+EDK + + E + E K+++ + +E +E E +E+E++ EE+ ++
Sbjct: 1511 QEDK-KLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQ 1569
Query: 319 EEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEE 378
EE K A R+R + E+KRA EER+ +EEEK A EERQ + +EE++ A+ + ++
Sbjct: 1570 EEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQ-LAQEERKLAQAYVKITQDDR 1628
Query: 379 EKAKVEEQ--KRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQ 436
E A+ E + ++ + L ++ + + K + +K+ KW EK A+E+ +K
Sbjct: 1629 EMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKW--EKVAREE-------EKL 1679
Query: 437 GEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKK-GFTEVKSQN 495
++ G + K Q+ + ++E+ D + K+ + EE++ M+ E+ +
Sbjct: 1680 AKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEE 1739
Query: 496 GEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLK 555
G+ + K K E + R + +E + A + E + +E + E EE E+L
Sbjct: 1740 GKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLG 1799
Query: 556 QKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIER 610
+K+++ + +L +KRE R + EE + + +K +EK+ L +E E+
Sbjct: 1800 RKREQLIEKKMKLAQKRE--RWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEK 1852
Score = 116 bits (290), Expect = 9e-26
Identities = 147/684 (21%), Positives = 298/684 (43%), Gaps = 111/684 (16%)
Query: 35 EEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEA 94
+E R + R+E QK+ + LG QV + V E T ++ +E
Sbjct: 1334 QEVIRHKEVMPREEEQAQKKARDMLGLEETQVILKKGKKVIFLEPGNVTMGKEISKKEEK 1393
Query: 95 AFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSE 154
++ ++ + ++ ++ + ++E ++ R M + E T EEK
Sbjct: 1394 KTFQKSPKQGRKAVQKERKVGKIKRE---------MTKEERDMSEEVEEMATL--EEKVV 1442
Query: 155 SRQERYEIEETETVTKSYQK--NDWRD--AEENK-----KEDKEKE--EEEEEKPKRGSI 203
++ + + E + ++K ++W+ E K KE+ EK +EEE+ + G
Sbjct: 1443 KQEGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAGEK 1502
Query: 204 GENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKE 263
+ E++ E+K + +E V S E+ ++EE +E+S E E+KE
Sbjct: 1503 LSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSR----EGEEKE 1558
Query: 264 RAEAERARLEAEER------------ERIKAEQDKKIADERARIEAEEKAAAQERERREA 311
+ E R EE E+ +A++++K+A E ++ EE+ AQE ER+ A
Sbjct: 1559 QQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQE-ERKLA 1617
Query: 312 EERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRI-KEEEKRAAEER 370
+ ++ ++++ A+ + ++E+ A+ +++ +E ++ A++R+++ K+ EK A EE
Sbjct: 1618 QAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEE 1677
Query: 371 QRAR-------------------AEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQ 411
+ A+ + E+ +E++ ++LEE + M+E K E++ Q
Sbjct: 1678 KLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQ 1737
Query: 412 KIEGKWVNEKKA----------QEDKLQTAVLKKQGEE-----KGTKVQAKREKLQEDKP 456
+ EGK V EKK Q +KL K EE + K+ +EK+ E++
Sbjct: 1738 E-EGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEE 1796
Query: 457 TF--KKEEIKDEKIK----------------KDKEPKEEVKSFMDRKKGFTEVKSQ---- 494
K+E++ ++K+K K+K + K+ KK + K +
Sbjct: 1797 RLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQR 1856
Query: 495 ------NGEFMTHKLKHTENTFSRPGG----RASVDTK-EAEGAPQVEAGKRLEELRRRR 543
N E +TH K ++ G A V+ K E ++ ++L E ++
Sbjct: 1857 KENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKL 1916
Query: 544 GETE---SEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEE 600
+ E +++ EKL Q++ + ALE ++ K+ R ++ +E++ E R E+
Sbjct: 1917 VQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMR 1976
Query: 601 KRRLKEEIERRRAEAAEKRQKMPE 624
KE + + +++KM +
Sbjct: 1977 LVEGKETLSKGETPETSRQRKMTQ 2000
Score = 103 bits (256), Expect = 8e-22
Identities = 145/721 (20%), Positives = 306/721 (42%), Gaps = 128/721 (17%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEEEAA----RERRRRARQERLRQK-------- 53
+ +E Q +E+M E ER+ +R E++ RER + +E + K
Sbjct: 1779 QEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKN 1838
Query: 54 --QEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRL 111
QE+++L Q +++ +N + ++E T + V+ ++ ++ + E + +
Sbjct: 1839 LAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQE 1898
Query: 112 QEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKS 171
+E + ++KE L + E+ +K+EK + + +E+ K
Sbjct: 1899 KETVIKKKE----------KLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKK 1948
Query: 172 YQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNG 231
+ + A+E K + E + EEK + E + E + + + V L
Sbjct: 1949 RLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFER 2008
Query: 232 QISSEEP----------KQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIK 281
++S EE +E E +G E + +++ + +R A+ +R ++RE +
Sbjct: 2009 KLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQG-QRKLAKASRKLIKKRESLS 2067
Query: 282 AEQDK--KIADERARIEAEEKAAAQE-------------RERREAEERERMREEEKRAAE 326
E K KI ++ +E+ QE +ERR + E+ ++ +E +E
Sbjct: 2068 KEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSE 2127
Query: 327 ERQRIKEEEKRAAEE--------RQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEE 378
+R + ++EK+ A + R+ I +EEK EE + ++ + ++ + EEE
Sbjct: 2128 KRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEE 2187
Query: 379 EKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKL--QTAVLKKQ 436
E +++ K+ E K+ + K + E + E + E ++ D+L Q ++ ++
Sbjct: 2188 EVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEE 2247
Query: 437 GEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNG 496
EE+ + + + E+++E++ K+EE +EK + +KE +E+ K ++KK
Sbjct: 2248 EEEREEEEEREEEEVREEEEERKEEEEGEEK-QVEKEEEEKKKKKKEKKK---------- 2296
Query: 497 EFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQ 556
+++ E F EE E E+E ++
Sbjct: 2297 ----EEVQEKEEVF--------------------------EEKEEIMSEEETESLSDEEE 2326
Query: 557 KQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEE-----------KRR-- 603
+++ +LE EE+ +++E +L++E+Q + QE+ + LR E K R
Sbjct: 2327 EEESCSLE-EEVDREKE----ILKKEKQFKLQEQRRKSLRGRERVLSILRGVPHGKGRAI 2381
Query: 604 ----LKEEIERRRAEAAEKRQK----MPEDGLS-DDKKPFKCFTPKGSSLKIEERAEFLN 654
LK +++ + A E ++K +PE +S +DKK P+ +++ E +
Sbjct: 2382 RLGVLKSPLKKLMSTALEMKEKTPVPVPEKQISWEDKKATVVEIPRKFLGTMDKEREVMG 2441
Query: 655 K 655
K
Sbjct: 2442 K 2442
Score = 60.8 bits (146), Expect = 5e-09
Identities = 87/371 (23%), Positives = 155/371 (41%), Gaps = 51/371 (13%)
Query: 288 IADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKE 347
+ E+ I +E A ++ + +E R +E R E+ Q+ K + EE Q I +
Sbjct: 1310 VPPEKKPIFIQEGAIREDMIQGVTQEVIRHKEVMPREEEQAQK-KARDMLGLEETQVILK 1368
Query: 348 EEKRAA----------------EERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQ 391
+ K+ EE++ ++ K+ + Q+ R + K ++ +++R+
Sbjct: 1369 KGKKVIFLEPGNVTMGKEISKKEEKKTFQKSPKQGRKAVQKERKVGKIKREMTKEERDMS 1428
Query: 392 LEEKKHAMQETKI---KGEKVEQKIEGKWVNEKKAQEDKLQT-----AVLKKQGEEKGTK 443
E ++ A E K+ +G+ V + W + KKA ++ Q K EE +
Sbjct: 1429 EEVEEMATLEEKVVKQEGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKR 1488
Query: 444 VQAKREKLQEDKPTFKKEEIKDEKIKKDKEPK-EEVKSFMDRKKGFTEVKSQNGEFMTHK 502
+ + EKL + EE E +++DK+ K EE K + KS+ ++ +
Sbjct: 1489 LLQEEEKLHQAGEKLSPEE---EMLQEDKKLKWEEWKQVWE---NMLSSKSKEQQYKDEE 1542
Query: 503 LKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAA 562
E SR G E + Q E + + R+R E K+ Q+E
Sbjct: 1543 EVTLEEEVSREGEEKEQQVTEEQRHIQEE--HKWARIHRKRARAEK------KRAQEERK 1594
Query: 563 LELEELKKKREERRKVLEEEEQRR---KQEEADRKLREEEEKRRLKEEIERRRAE----- 614
L EE K +EER+ EE + + K + DR++ + E K KEE +R E
Sbjct: 1595 LAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQE 1654
Query: 615 ---AAEKRQKM 622
A+KR+K+
Sbjct: 1655 AEKLAQKRKKL 1665
Score = 53.1 bits (126), Expect = 1e-06
Identities = 123/649 (18%), Positives = 261/649 (40%), Gaps = 119/649 (18%)
Query: 108 QKRLQEALERQKEFDPTITDASLSLPSR-----RMQNDTAENETTEKEEKSESRQERYEI 162
++RL E L + +S+PS + + E+E K K + R +
Sbjct: 1031 EQRLNENLTLSHRDEKPAFSLDVSMPSELKSSLKPPTVSEESEVAIKPSKGQRRGQAGVK 1090
Query: 163 EETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEE 222
+ ++ + +K RD+++ E E+E G + +EE + SQ
Sbjct: 1091 KHSQKWLRGLKKTKERDSKQMSTEPGLLEDES---------GTEAAPIEMEEASVYSQ-- 1139
Query: 223 TVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKA 282
S I + +E++ D I+ K ++ +++ + + + +++ + K
Sbjct: 1140 ---WSSSTSVIKLSKDVDSQEKDISKDHIALTLKRLQKIRDKRDKKATAQKLKKKHKKKG 1196
Query: 283 EQDKKIADERA----------RIEAEEKAAAQERERRE-AEERERMREEEKRAAEER--- 328
++ K I +E +++ + + A+ RR A + R++ R R
Sbjct: 1197 KEAKVINEETTPPVMEQPVTKKVKIQGRGASGISGRRSTAGDGSSWRDDLCRLMALRISG 1256
Query: 329 ------QRIKEEEKRAAEER---------------QRIKEEEKRAAE---------ERQR 358
+ + E A+E +K+E K E E++
Sbjct: 1257 SQTKMSENLNAELVTFAQEMLVDRHPSWELFQEICPLLKKESKVLLEDLDWDVVPPEKKP 1316
Query: 359 IKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAM---QETKI---KGEKV--- 409
I +E E+ + +E + K + +Q ++K M +ET++ KG+KV
Sbjct: 1317 IFIQEGAIREDMIQGVTQEVIRHKEVMPREEEQAQKKARDMLGLEETQVILKKGKKVIFL 1376
Query: 410 --EQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKV-QAKREKLQEDKPTFKKEEIKDE 466
GK +++K+ ++ ++ ++ +K KV + KRE +E++ EE+++
Sbjct: 1377 EPGNVTMGKEISKKEEKKTFQKSPKQGRKAVQKERKVGKIKREMTKEERDM--SEEVEEM 1434
Query: 467 KIKKDKEPKEEVK--------SFMDRKKGFTEVKSQNGEFMTH----------KLKHTEN 508
++K K+E K S+ D KK + E K +GE +L E
Sbjct: 1435 ATLEEKVVKQEGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEE 1494
Query: 509 TFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEEL 568
+ G + S + E Q + + EE ++ S + ++ + K +E EE+
Sbjct: 1495 KLHQAGEKLSPE----EEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEV 1550
Query: 569 KKKREERRKVLEEEEQ-----------RRKQEEADRKLREEEEKRRLKEE-IERRRAEAA 616
++ EE+ + + EE++ RK+ A++K +EE K +EE + + + A
Sbjct: 1551 SREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLA 1610
Query: 617 EKRQKMPEDGL---SDDKKPFKC---FTPKGSSLKIEERAEFLNKSVQK 659
++ +K+ + + DD++ + F K +L +R E L++ +K
Sbjct: 1611 QEERKLAQAYVKITQDDREMAQAEGKFAQKEETL--AQRGEKLSQEAEK 1657
Score = 43.1 bits (100), Expect = 0.001
Identities = 31/128 (24%), Positives = 63/128 (49%), Gaps = 16/128 (12%)
Query: 1 MDDFERRRELRRQKREEMRLEAER----IAYQRNDDDEEEAARERRRRARQERLRQKQEE 56
+D+ E++ L ++ EE E ER + + + EEE E++ +E ++K++E
Sbjct: 2234 LDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKE 2293
Query: 57 ESLGQVTDQVEVNAQN----------SVPDEEAKTTTTNTQVEGDDEAAFL--ERLARRE 104
+ +V ++ EV + S+ DEE + + + + E D E L E+ + +
Sbjct: 2294 KKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDREKEILKKEKQFKLQ 2353
Query: 105 ERRQKRLQ 112
E+R+K L+
Sbjct: 2354 EQRRKSLR 2361
>gi|148839339 nexilin (F actin binding protein) [Homo sapiens]
Length = 675
Score = 132 bits (333), Expect = 1e-30
Identities = 148/605 (24%), Positives = 272/605 (44%), Gaps = 104/605 (17%)
Query: 89 EGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTE 148
+GD + F REER Q+R ++ +R+KE I + + RR Q + +
Sbjct: 28 KGDVKDKFEAMQRAREERNQRRSRDEKQRRKE--QYIREREWN---RRKQEIKEMLASDD 82
Query: 149 KEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQV 208
+E+ S ++ Y + T TV K + + E+ ++E++ K EEE K +
Sbjct: 83 EEDVSSKVEKAYVPKLTGTV-----KGRFAEMEKQRQEEQRKRTEEERKRR--------- 128
Query: 209 EVMVEEKTTESQEETVVMSLKNGQISS-EEPKQEEEREQGSDEI------------SHHE 255
+E+ E ++ ++ + QI E E+G D + S
Sbjct: 129 ---IEQDMLEKRKIQRELAKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKM 185
Query: 256 KMEEEDKERAEAERARLEAEERERIKAEQDKK----------IADERARIEAEEKAAAQE 305
K ED E+ E+ R++ EE +RI+ E+ + + D+ EA++++ +
Sbjct: 186 KKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPG 245
Query: 306 RERREAEERERMREE--EKRAAEERQRIKEEEKRAAEE--RQRIKEEEKRAAE------- 354
+ + EE ER R+E +K+A EE ++ EEEKRA EE RQ + E+E+
Sbjct: 246 KLKLTFEELERQRQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGY 305
Query: 355 ------------ERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQET 402
ERQR +E+EKR AEE R R EEE+KA E +RN +++ M +T
Sbjct: 306 RPGKLKLSFEEMERQR-REDEKRKAEEEARRRIEEEKKA-FAEARRNMVVDDDSPEMYKT 363
Query: 403 KIKGEKVEQKIEGKWVN--EKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKK 460
+ K+E + ++K +E+K +T EE+ K++ ++++ ++ + +
Sbjct: 364 ISQEFLTPGKLEINFEELLKQKMEEEKRRTE------EERKHKLEMEKQEFEQLRQEMGE 417
Query: 461 EEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVD 520
EE ++E +E +E +K ++G LK + F + G +
Sbjct: 418 EEEENETFGLSREYEELIKL------------KRSGSIQAKNLK---SKFEKIG---QLS 459
Query: 521 TKEAEGAPQVEAGKRLE---ELRRRRGETESEEFE---KLKQKQQEAALELEELKKKREE 574
KE + + E +R E++ R E EE + + +K + +K + E+
Sbjct: 460 EKEIQKKIEEERARRRAIDLEIKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQ 519
Query: 575 RRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPF 634
K EEEEQRR +E+ + LR + E+R + ++++R E E+ + ++D++
Sbjct: 520 MAKAREEEEQRRIEEQ--KLLRMQFEQREIDAALQKKREEEEEEEGSIMNGSTAEDEEQT 577
Query: 635 KCFTP 639
+ P
Sbjct: 578 RSGAP 582
Score = 110 bits (276), Expect = 4e-24
Identities = 149/621 (23%), Positives = 278/621 (44%), Gaps = 109/621 (17%)
Query: 3 DFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQV 62
D + + E ++ REE QR DE++ +E+ R R+ R+KQE + +
Sbjct: 30 DVKDKFEAMQRAREERN--------QRRSRDEKQRRKEQYIREREWN-RRKQEIKEMLAS 80
Query: 63 TDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFD 122
D+ +V+++ E+A V+G F E +R+E ++KR +E +R+ E D
Sbjct: 81 DDEEDVSSKV----EKAYVPKLTGTVKG----RFAEMEKQRQEEQRKRTEEERKRRIEQD 132
Query: 123 PTITDASLSLPSRRMQNDTAEN-------ETTEKEEKSESRQERYEIEETETVTKSYQ-- 173
L R++Q + A+ T E SE + I T KSY+
Sbjct: 133 --------MLEKRKIQRELAKRAEQIEDINNTGTESASEEGDDSLLI--TVVPVKSYKTS 182
Query: 174 ---KNDWRDAEENKKEDKEKEEEEEEK-----PKRGSIGENQVEVMVEEKTTESQEETVV 225
K ++ D E+ ++E+KE+ + EE+K +R S+ E + +V + ES+ +
Sbjct: 183 GKMKKNFEDLEK-EREEKERIKYEEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKES 241
Query: 226 MSLKNGQISSEE---PKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKA 282
+S +++ EE +QE ++Q +E +++EEE + EA R + +E + A
Sbjct: 242 LSPGKLKLTFEELERQRQENRKKQAEEEA--RKRLEEEKRAFEEARRQMVNEDEENQDTA 299
Query: 283 EQDKKIADERARIEAEEKAAAQERERREAEERE------RMREEEKRAAEERQRIKEEEK 336
+ K + ++ EE ER+RRE E+R+ R EEEK+A E +R +
Sbjct: 300 KIFKGYRPGKLKLSFEE----MERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDD 355
Query: 337 RAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKK 396
+ E + I +E + +E K+ EE +R R EEE K K+E +K+ +
Sbjct: 356 DSPEMYKTISQEFLTPGKLEINFEELLKQKMEEEKR-RTEEERKHKLEMEKQEFE----- 409
Query: 397 HAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKP 456
+++ E E++ E + + E+ ++ LK+ G + +++K EK+
Sbjct: 410 ------QLRQEMGEEEEENETFGLSREYEELIK---LKRSGSIQAKNLKSKFEKI----- 455
Query: 457 TFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGR 516
++ +++I+K E + + +D E+K + E ++ RP +
Sbjct: 456 ----GQLSEKEIQKKIEEERARRRAID-----LEIKEREAE----NFHEEDDVDVRPARK 502
Query: 517 ASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLK-------QKQQEAALELEELK 569
+ EA +V R E++ + R E E E+ K Q++ +AAL+ + +
Sbjct: 503 S-----EAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKLLRMQFEQREIDAALQKKREE 557
Query: 570 KKREE----RRKVLEEEEQRR 586
++ EE E+EEQ R
Sbjct: 558 EEEEEGSIMNGSTAEDEEQTR 578
Score = 92.4 bits (228), Expect = 1e-18
Identities = 114/471 (24%), Positives = 206/471 (43%), Gaps = 98/471 (20%)
Query: 290 DERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKE-EEKRAAEERQRIKEE 348
D + + EA ++A + +RR +E++R +E+ R E +R +E +E A+++ + + +
Sbjct: 30 DVKDKFEAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSK 89
Query: 349 EKRA-------------AE-ERQRIKEEEKRAAEERQRARAEEE--EKAKVEEQ--KRNK 390
++A AE E+QR +E+ KR EER+R R E++ EK K++ + KR +
Sbjct: 90 VEKAYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEERKR-RIEQDMLEKRKIQRELAKRAE 148
Query: 391 QLEEKKHAMQET--------------KIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQ 436
Q+E+ + E+ +K K K++ + + +K +E+K + K
Sbjct: 149 QIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKERI----KY 204
Query: 437 GEEKGTKVQAKREKLQEDK-----------PTFKKEEIKDEKIK-------------KDK 472
E+K + + +R L+E K KKE + K+K + K
Sbjct: 205 EEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKK 264
Query: 473 EPKEEV-KSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFS-----RPGGRASVDTKEAEG 526
+ +EE K + K+ F E + Q M ++ + ++T RP G+ + +E E
Sbjct: 265 QAEEEARKRLEEEKRAFEEARRQ----MVNEDEENQDTAKIFKGYRP-GKLKLSFEEMER 319
Query: 527 APQVEAGKRLEELRRRRGETESEEFEKLKQKQ-------------QEAALELEELKKKRE 573
+ + ++ EE RRR E E + F + ++ + L +L+ E
Sbjct: 320 QRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFE 379
Query: 574 ERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKP 633
E K EEE+RR +EE KL E K+E E+ R E E+ ++ GLS + +
Sbjct: 380 ELLKQKMEEEKRRTEEERKHKLEME------KQEFEQLRQEMGEEEEENETFGLSREYEE 433
Query: 634 FKCFTPKGS------SLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSR 678
GS K E+ + K +QK + + AI +I R
Sbjct: 434 LIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKER 484
Score = 43.5 bits (101), Expect = 8e-04
Identities = 56/240 (23%), Positives = 100/240 (41%), Gaps = 29/240 (12%)
Query: 1 MDDFERRRELRRQKREEM-RLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESL 59
M++ +RR E R+ + EM + E E++ + +++EE E +E E L
Sbjct: 386 MEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEEE-----------NETFGLSREYEEL 434
Query: 60 GQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQK 119
++ + A+N E + +++ E ER RR + + +EA +
Sbjct: 435 IKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEE---ERARRRAIDLEIKEREAENFHE 491
Query: 120 EFDPTITDASLS-LPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWR 178
E D + A S P N A E+ K+ +E+ IEE + + +++ R
Sbjct: 492 EDDVDVRPARKSEAPFTHKVNMKAR---FEQMAKAREEEEQRRIEEQKLLRMQFEQ---R 545
Query: 179 DAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEP 238
+ + ++ +E+EEEEE GS E +E+ T S LKN + EP
Sbjct: 546 EIDAALQKKREEEEEEEGSIMNGSTAE-------DEEQTRSGAPWFKKPLKNTSVVDSEP 598
Score = 41.6 bits (96), Expect = 0.003
Identities = 45/202 (22%), Positives = 83/202 (41%), Gaps = 33/202 (16%)
Query: 493 SQNGEFMTHKLKHTENTFSRPGGRASVDTK-EAEGAPQVEAGKRL---EELRRRRGETES 548
SQ E + K T+ G+ V K EA + E +R E+ RR+
Sbjct: 5 SQKAEILLSSSKPVPKTYVPKLGKGDVKDKFEAMQRAREERNQRRSRDEKQRRKEQYIRE 64
Query: 549 EEFEKLKQK---------QQEAALELEEL-----------------KKKREERRKVLEEE 582
E+ + KQ+ +++ + ++E+ K+++EE+RK EEE
Sbjct: 65 REWNRRKQEIKEMLASDDEEDVSSKVEKAYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEE 124
Query: 583 EQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGS 642
+RR +++ K + + E + E+IE E + +D L P K + G
Sbjct: 125 RKRRIEQDMLEKRKIQRELAKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSG- 183
Query: 643 SLKIEERAEFLNKSVQKSSGVK 664
K+++ E L K ++ +K
Sbjct: 184 --KMKKNFEDLEKEREEKERIK 203
>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
Length = 843
Score = 131 bits (330), Expect = 2e-30
Identities = 117/463 (25%), Positives = 217/463 (46%), Gaps = 61/463 (13%)
Query: 170 KSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTE----SQEETVV 225
K+ +K +A + ++E +EE +R + + +EV++ E ++E SQE
Sbjct: 173 KAKKKASNGNARPETVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSELNAPSQESDSH 232
Query: 226 MSLKNGQ-------------------ISSEE----PKQEEEREQGSDEISH----HEKME 258
K + I+ E+ +E++R+ S EIS H+K+E
Sbjct: 233 PRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFRDTHKKLE 292
Query: 259 EEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMR 318
EE K + E ER +E E RER + ER R E E + +ERER E+E+ R
Sbjct: 293 EE-KGKKEKERQEIEKERRERER---------ERER-ERERREREREREREREREKEKER 341
Query: 319 EEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEE 378
E E+ +R R KE ++ ER R ++ E+ + + R + EK ER+R R E
Sbjct: 342 ERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERER 401
Query: 379 EKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGE 438
E+ + E++R ++ E ++ +E + K +K +++ + + E++ E KL+ Q
Sbjct: 402 ERERERERERERERERERERERERE-KDKKRDREEDEEDAYERRKLERKLREKEAAYQER 460
Query: 439 EKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEF 498
K +++ +++ + +K ++EE + E K+ K KE ++ + D + + K G
Sbjct: 461 LKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDR---DDPKYYRGSA 517
Query: 499 MTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRR-RGETESEEFEKLKQK 557
+ +L+ E EA+ + + LEE+R+R E + +L++
Sbjct: 518 LQKRLRDREKEM------------EADERDRKREKEELEEIRQRLLAEGHPDPDAELQRM 565
Query: 558 QQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEE 600
+QEA + K+ E + EEEE++ K+E+ + + EEEE
Sbjct: 566 EQEAERRRQPQIKQEPESEE--EEEEKQEKEEKREEPMEEEEE 606
Score = 114 bits (284), Expect = 5e-25
Identities = 102/463 (22%), Positives = 206/463 (44%), Gaps = 62/463 (13%)
Query: 65 QVEVNAQNSVPDEEAKTTTTNTQ-----VEGDDEAAFLERLARREERRQKRLQEALERQK 119
+V+ + + + +AK +N V DDE A E RR++ + ++ +
Sbjct: 160 KVDAKTKAQLDEWKAKKKASNGNARPETVTNDDEEALDEETKRRDQMIKGAIEVLIREYS 219
Query: 120 EFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEI-----------EETETV 168
+ L+ PS+ ++ + +K+EK E R+ + E+ +
Sbjct: 220 --------SELNAPSQ----ESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAI 267
Query: 169 TKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSL 228
K D E +K D K+ EEE+ K E + E E+ E + E
Sbjct: 268 EMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRERER 327
Query: 229 KNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERA-EAERARLEAEERERIKAEQDKK 287
+ + E ++E ERE+ D K + D++R + +R R + +R + ++ +K
Sbjct: 328 EREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREK 387
Query: 288 IAD-ERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIK 346
D ER R E+ +ERER ERER RE E+ ++++R +EE++ A ER++++
Sbjct: 388 SRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLE 447
Query: 347 EE--EKRAA----------EERQRIKEEEKRAAEERQRARAEEEEKAKVEE--------- 385
+ EK AA ER++ +E EK A E +R R +E +++E
Sbjct: 448 RKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDR 507
Query: 386 -----------QKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLK 434
QKR + E++ A + + + ++ ++I + + E D + +
Sbjct: 508 DDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQ 567
Query: 435 KQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEE 477
+ + +++ + E +E++ +KEE ++E +++++EP+++
Sbjct: 568 EAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQK 610
Score = 93.2 bits (230), Expect = 8e-19
Identities = 90/384 (23%), Positives = 168/384 (43%), Gaps = 53/384 (13%)
Query: 8 RELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVE 67
RE+ + + +LE E+ ++ + E+ RER R +ER R+++E E + + E
Sbjct: 279 REISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERREREREREREREREKE 338
Query: 68 VNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITD 127
+ + + T + D RE R + + + +R K+
Sbjct: 339 KERERERERDRDRDRTKERDRDRD-----------RERDRDRDRERSSDRNKD------- 380
Query: 128 ASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKED 187
SR D E+E + E +ER E E ++ R+ E++KK D
Sbjct: 381 ---RSRSREKSRDRERERERERERERERERERERERERER-----EREREREREKDKKRD 432
Query: 188 KEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQG 247
+E++EE+ + ++ +E + EK QE LKN +I + +E E+E
Sbjct: 433 REEDEEDAYERRK-------LERKLREKEAAYQER-----LKNWEIRERKKTREYEKEA- 479
Query: 248 SDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERE 307
E+ EE +E A+ E RL +E ++ D + + R A +K +
Sbjct: 480 -------EREEERRREMAK-EAKRL----KEFLEDYDDDRDDPKYYRGSALQKRLRDREK 527
Query: 308 RREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAA 367
EA+ER+R RE+E+ ++ + E E QR+++E +R + +IK+E +
Sbjct: 528 EMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAER--RRQPQIKQEPESEE 585
Query: 368 EERQRARAEEEEKAKVEEQKRNKQ 391
EE ++ EE+ + +EE++ +Q
Sbjct: 586 EEEEKQEKEEKREEPMEEEEEPEQ 609
Score = 92.4 bits (228), Expect = 1e-18
Identities = 95/381 (24%), Positives = 180/381 (47%), Gaps = 50/381 (13%)
Query: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDD-----EAAFLERLARREERRQKRLQEALERQK 119
++E + ++ + E +K T+ ++E + E +E+ R ER ++R +E ER++
Sbjct: 268 EMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRERER 327
Query: 120 EFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRD 179
E + R + D + T E++ + ++R E + K+ R
Sbjct: 328 EREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSS---DRNKDRSRS 384
Query: 180 AEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPK 239
E+++ ++E+E E E + +R E+ E + E E +
Sbjct: 385 REKSRDRERERERERERERER-------------ERERERERE-------------RERE 418
Query: 240 QEEEREQGSDEISHHEKMEEEDKERAEAER--ARLEAEERERIKAEQDKKIADERARIEA 297
+E ERE+ D+ E+ EE+ ER + ER EA +ER+K + +I + + E
Sbjct: 419 REREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLK---NWEIRERKKTREY 475
Query: 298 EEKAAAQERERRE-AEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEER 356
E++A +E RRE A+E +R++E + ++R K A ++R R +E+E A+ER
Sbjct: 476 EKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEME-ADER 534
Query: 357 QRIKEEEKRAAEERQRARAE-----EEEKAKVE---EQKRNKQLEEKKHAMQETKIKGEK 408
R K E++ E RQR AE + E ++E E++R Q++++ + +E + K EK
Sbjct: 535 DR-KREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEK 593
Query: 409 VEQKIEGKWVNEKKAQEDKLQ 429
E++ E E+ Q+ L+
Sbjct: 594 EEKREEPMEEEEEPEQKPCLK 614
Score = 92.0 bits (227), Expect = 2e-18
Identities = 86/349 (24%), Positives = 152/349 (43%), Gaps = 41/349 (11%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTD 64
+ R+E+ +++RE R E ER +R + E E RER + +ER R++ + + D
Sbjct: 300 KERQEIEKERRERER-ERERERERREREREREREREREKEKERERERERDRDRDRTKERD 358
Query: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPT 124
+ ++ D E + + +++ ER RE R++ + ER++E +
Sbjct: 359 RDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERERERE-- 416
Query: 125 ITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIE----ETETVTKSYQKNDWRDA 180
R + + +++ ++EE E ER ++E E E + KN W
Sbjct: 417 --------REREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKN-WEIR 467
Query: 181 EENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQ 240
E K + EKE E EE+ +R E+ E K LK ++ +
Sbjct: 468 ERKKTREYEKEAEREEERRR--------EMAKEAK-----------RLKEFLEDYDDDRD 508
Query: 241 EEEREQGS---DEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEA 297
+ + +GS + EK E D+ + E+ LE E R+R+ AE E R+E
Sbjct: 509 DPKYYRGSALQKRLRDREKEMEADERDRKREKEELE-EIRQRLLAEGHPDPDAELQRMEQ 567
Query: 298 EEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIK 346
E + Q + ++E E E EEEK+ EE++ EE+ E++ +K
Sbjct: 568 EAERRRQPQIKQEPESEE--EEEEKQEKEEKREEPMEEEEEPEQKPCLK 614
Score = 73.2 bits (178), Expect = 9e-13
Identities = 81/382 (21%), Positives = 171/382 (44%), Gaps = 32/382 (8%)
Query: 285 DKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQR 344
D +I +++ ++ + K AQ +E + ++ A ++E+ EE +R
Sbjct: 149 DLQIGEKKLLVKVDAKTKAQ------LDEWKAKKKASNGNARPETVTNDDEEALDEETKR 202
Query: 345 IKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQL----------EE 394
+ K A E R E A + + +++K K E+ R + +E
Sbjct: 203 RDQMIKGAIEVLIREYSSELNAPSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKE 262
Query: 395 KKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQED 454
+A++ + K + + ++I KK +E+K + +++ E++ + + +RE+ +E
Sbjct: 263 DINAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERER 322
Query: 455 KPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPG 514
+ ++E ++ + +++KE + E + DR + T+ + ++ + + + E + R
Sbjct: 323 R---EREREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNK 379
Query: 515 GRASVDTKEAEGAPQVEAGKRLEELRRRRGETESE-------EFEKLKQKQQEAALELEE 567
R+ K + + E + E R R E E E E E+ K K+++ + E+
Sbjct: 380 DRSRSREKSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEED 439
Query: 568 LKKKREERRKVLEEE----EQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMP 623
++R+ RK+ E+E E+ + E +RK E EK +EE RR KR K
Sbjct: 440 AYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEF 499
Query: 624 EDGLSDDKKPFKCFTPKGSSLK 645
+ DD+ K + +GS+L+
Sbjct: 500 LEDYDDDRDDPKYY--RGSALQ 519
Score = 61.2 bits (147), Expect = 4e-09
Identities = 55/237 (23%), Positives = 106/237 (44%), Gaps = 20/237 (8%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTD 64
+R RE R++ E E ER +R + E E RER R ++R R++ EE++ +
Sbjct: 390 DRERERERERERERERERER---EREREREREREREREREKDKKRDREEDEEDAYERRKL 446
Query: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEF--- 121
+ ++ + + E K N ++ + E+ A REE R++ + + +R KEF
Sbjct: 447 ERKLREKEAAYQERLK----NWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLED 502
Query: 122 ------DPTITDASL---SLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSY 172
DP S L R + + E + ++E+ E ++R E
Sbjct: 503 YDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAEL 562
Query: 173 QKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLK 229
Q+ + ++AE ++ ++E E EE+ + E + E +EE+ Q+ + +L+
Sbjct: 563 QRME-QEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQKPCLKPTLR 618
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 129 bits (323), Expect = 1e-29
Identities = 159/718 (22%), Positives = 301/718 (41%), Gaps = 47/718 (6%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTD 64
+R E + + MR E I R E + + RQ+ E E Q
Sbjct: 298 DRLSEAAKVNTDAMRSAQEEITEYRRQLQARTTELEALKSTKDSLERQRSELEDRHQADI 357
Query: 65 QVEVNAQNSVPDEEAKTTTTN----TQVEGDDEAAFLERLARREERRQKRLQEALERQKE 120
+ Q ++ +A+ T Q+ + ++ E ++L E E +
Sbjct: 358 ---ASYQEAIQQLDAELRNTKWEMAAQLREYQDLLNVKMALDIEIAAYRKLLEGEECRIG 414
Query: 121 FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA 180
F P LP + +T + KSE + + E E ETV Q + +
Sbjct: 415 FGPIPFSLPEGLPK-------IPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVT 467
Query: 181 EENKKEDKEKEEEEEEKPKRGSI------GENQVEVMVEEKTTESQEETVVMSLKNGQIS 234
EE +E++++ +EEE K + G GE + + E+ ++E + +
Sbjct: 468 EEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSP 527
Query: 235 SEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERAR 294
+E E+E + E+ EK + KE A++ ++ E+E K+ + K + E+A+
Sbjct: 528 AEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSP-PEAKSPEKEEAKSPAEVK-SPEKAK 585
Query: 295 IEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAE 354
A+E+A + + + + ++EE K AE + +KEE K AE +K EK +
Sbjct: 586 SPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAE----VKSPEKAKSP 641
Query: 355 ERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIE 414
++ K EK + E++ A++ E+ K+ V+ + K E+ K ++ EK + ++
Sbjct: 642 TKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEA--KSPEKAKSPVKAEAKSPEKAKSPVK 699
Query: 415 GKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEP 474
+ + +KA+ + A K E+ + V+ + + ++ K K+E EK K ++
Sbjct: 700 EEAKSPEKAKSPVKEEA---KSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKA 756
Query: 475 KE-EVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAG 533
K +VKS + E +S +F K K + +A KE AP+ E
Sbjct: 757 KTLDVKSPEAKTPAKEEARSPADKF-PEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIP 815
Query: 534 KRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADR 593
K+ EE++ E E + K+K+ ++A E K EE++ +EE +++ +
Sbjct: 816 KK-EEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKV 874
Query: 594 KLREEEEKRRLKEEIERRRAEAAEKRQKMP--------EDGLSDDKKPFKCFTPKGSSLK 645
+ ++E + KE + E AE ++K+P + + +D KP K T
Sbjct: 875 EEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKP-KEKTEVAKKEP 933
Query: 646 IEERAEFLNKSVQKSSGV--KSTHQAAIVSKIDSRLEQYTSAIEGTK--SAKPTKPAA 699
+ +A+ +K +K K + K + + + A E K S +P+KP A
Sbjct: 934 DDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKA 991
Score = 127 bits (320), Expect = 3e-29
Identities = 153/637 (24%), Positives = 277/637 (43%), Gaps = 83/637 (13%)
Query: 35 EEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEA 94
EE + + ++ + ++Q EE+ QVT++V + +EE K + EG +E
Sbjct: 441 EEKIKVVEKSEKETVIVEEQTEET--QVTEEVTEEEEKEAKEEEGK------EEEGGEEE 492
Query: 95 AFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSE 154
E EE + +EA +KE + + + S AE ++ EKEE ++
Sbjct: 493 ---EAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKS---------PAEAKSPEKEE-AK 539
Query: 155 SRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEE 214
S E E+ ++ K K+ +A+ +KE+ + E + K S + + + E
Sbjct: 540 SPAEVKSPEKAKSPAKEEAKSP-PEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEA 598
Query: 215 KTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERA--------- 265
K+ E + V K+ ++ P +EE + E+ EK + KE A
Sbjct: 599 KSPEKAKSPVKEEAKS-PAEAKSPVKEEAKSPA--EVKSPEKAKSPTKEEAKSPEKAKSP 655
Query: 266 EAERARLEAEERERIKAEQ---DKKIADERARIEAEEKAAAQERERREAEERER--MREE 320
E E A+ + + +KAE +K + +A ++ EKA + +E ++ E+ + ++EE
Sbjct: 656 EKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEE 715
Query: 321 EKRAAEERQRIKEEEKRAAEERQRIKEE----EKRAAEERQRIKE----EEKRAAEERQR 372
K + + +KEE K + + +KEE EK + E+ + + E K A+E R
Sbjct: 716 AKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEAR 775
Query: 373 ARAEE-EEKAKVEEQKRNKQLEEKKHAMQETKIKGEKV---EQKIEGKWVNEKKAQEDKL 428
+ A++ EKAK ++ K E+ K ++E EK +++++ E+K QE K+
Sbjct: 776 SPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKV 835
Query: 429 QTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGF 488
+ KK EEK EK K K+E K+++ KEP E K+
Sbjct: 836 KEPP-KKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKP-----KESK 889
Query: 489 TEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETES 548
E K + E + V T E E +VE ++E + + +TE
Sbjct: 890 VEAKKEEAE-----------------DKKKVPTPEKEAPAKVE----VKEDAKPKEKTEV 928
Query: 549 EEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEI 608
+ E K +E + E KK+ +K +EE+ ++ +E+ + + +E+ + L +E
Sbjct: 929 AKKEPDDAKAKEPSKPAE--KKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEP 986
Query: 609 ERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLK 645
+ +AE AEK + D K P K K + K
Sbjct: 987 SKPKAEKAEKSSSTDQ---KDSKPPEKATEDKAAKGK 1020
Score = 123 bits (309), Expect = 6e-28
Identities = 186/781 (23%), Positives = 311/781 (39%), Gaps = 92/781 (11%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERL----RQKQEE--ESL 59
+R + ++REE A +A + + +++ +A QE R QEE E L
Sbjct: 183 QRLDDEARQREEAEAAARALARFAQEAEAARVDLQKKAQALQEECGYLRRHHQEEVGELL 242
Query: 60 GQVTDQVEVNAQNSVPDEEA-KTTTTNT------QVEG-------DDEAAF---LERLAR 102
GQ+ AQ +A K T+ Q+EG E F L+RL+
Sbjct: 243 GQIQGSGAAQAQMQAETRDALKCDVTSALREIRAQLEGHAVQSTLQSEEWFRVRLDRLSE 302
Query: 103 REERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEI 162
+ ++ A E E+ + + L + + D+ E + +E E++ ++ Y+
Sbjct: 303 AAKVNTDAMRSAQEEITEYRRQLQARTTELEALKSTKDSLERQRSELEDRHQADIASYQ- 361
Query: 163 EETETVTKSYQKNDWRDAEENKKED-----------------KEKEEEE----------- 194
E + + + W A + ++ K E EE
Sbjct: 362 EAIQQLDAELRNTKWEMAAQLREYQDLLNVKMALDIEIAAYRKLLEGEECRIGFGPIPFS 421
Query: 195 --EEKPKRGSIGENQVEVMVEEK---TTESQEETVVMSLKNGQIS-SEEPKQEEEREQGS 248
E PK S+ + ++V EEK +S++ETV++ + + +EE +EEE+E
Sbjct: 422 LPEGLPKIPSVSTH-IKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKE 480
Query: 249 DEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERER 308
+E E EEE+ E E E AEE + E + +E A+ AE K+ +E +
Sbjct: 481 EEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEE-AKSPAEAKSPEKEEAK 539
Query: 309 REAE------ERERMREEEKRAAEERQRIKEEEKRAAE------ERQRIKEEEKRAAEER 356
AE + +EE K E + KEE K AE + KEE K AE +
Sbjct: 540 SPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAK 599
Query: 357 QR------IKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVE 410
+KEE K AE + + E + A+V+ ++ K +++ E EK E
Sbjct: 600 SPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEE 659
Query: 411 QKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDE--KI 468
K K + KA+ + A + E K + K + P K +K+E
Sbjct: 660 AKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSP 719
Query: 469 KKDKEP-KEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGA 527
+K K P KEE K+ +K + VK + K T A KE +
Sbjct: 720 EKAKSPVKEEAKT---PEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARS 776
Query: 528 PQVEAGKRLEELRRR-RGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEE-QR 585
P A K E+ + + E +S E K K+ A E +E+ KK E + V EEE+ Q
Sbjct: 777 P---ADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPE-KEIPKKEEVKSPVKEEEKPQE 832
Query: 586 RKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLK 645
K +E +K EE+ K E ++ + +++ P+ + + K+P PK S ++
Sbjct: 833 VKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEP-AVEKPKESKVE 891
Query: 646 I-EERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPV 704
+E AE K + + +K + E + K+ +P+KPA
Sbjct: 892 AKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAA 951
Query: 705 P 705
P
Sbjct: 952 P 952
Score = 109 bits (272), Expect = 1e-23
Identities = 137/568 (24%), Positives = 246/568 (43%), Gaps = 67/568 (11%)
Query: 13 QKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEE------ESLGQVTDQV 66
Q EE+ E E+ A + +EE E +E EE E+ V ++
Sbjct: 465 QVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEA 524
Query: 67 EVNAQNSVPD-EEAKT-----------TTTNTQVEGDDEAAFLERLARREERRQKRLQEA 114
+ A+ P+ EEAK+ + + + EA E+ + K ++A
Sbjct: 525 KSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKA 584
Query: 115 LERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQK 174
KE + +A ++ + A++ K E + E++ E KS K
Sbjct: 585 KSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKA-KSPTK 643
Query: 175 NDWRDAEENKKEDKEKEEEEEE-----KPKRGSIGENQVEVMVEEKTTESQEETVVMSLK 229
+ + E+ K +KE+ + E+ K + S + + V E K+ E + V K
Sbjct: 644 EEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAK 703
Query: 230 NGQ-----ISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERER--IKA 282
+ + + E E+ + +E EK + KE A++ E+ + +K+
Sbjct: 704 SPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKS 763
Query: 283 EQDKKIADERARIEAE---EKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAA 339
+ K A E AR A+ EKA + +E ++ E+ + +E A E++ K+EE ++
Sbjct: 764 PEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSP 823
Query: 340 EERQRIKEEEKRAAEERQRIKEEEKRAAEERQRA--RAEEEEKAKVEEQKRNK----QLE 393
+KEEEK + ++KE K+A EE+ A + EE++ +K EE + + ++E
Sbjct: 824 -----VKEEEK---PQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVE 875
Query: 394 EKKHAM----QETKIKGEKVEQKIEGK----------WVNEKKAQEDKLQTAVLKKQGEE 439
EKK +E+K++ +K E + + K V K+ + K +T V KK+ ++
Sbjct: 876 EKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDD 935
Query: 440 KGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKE-PKEEVKSFMDRKKGFTEVKSQNGEF 498
K +K + +E P +K++ K+EK KK +E PK E K+ D K E E
Sbjct: 936 AKAKEPSKPAEKKEAAP--EKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAE- 992
Query: 499 MTHKLKHTENTFSRPGGRASVDTKEAEG 526
K T+ S+P +A+ D K A+G
Sbjct: 993 KAEKSSSTDQKDSKPPEKATED-KAAKG 1019
Score = 81.3 bits (199), Expect = 3e-15
Identities = 84/412 (20%), Positives = 180/412 (43%), Gaps = 35/412 (8%)
Query: 9 ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEV 68
E++ ++ + + E + ++ E+E A+ + + K E++ V + +
Sbjct: 631 EVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKS 690
Query: 69 NAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDA 128
+ P +E + + +EA E+ + K ++A KE + A
Sbjct: 691 PEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKA 750
Query: 129 SLSLPSRRMQNDTAENETTEKEEKSESRQE---------RYEIEETETVTKSYQKNDWRD 179
++ + + E +T KEE + + E++ E KS K D +
Sbjct: 751 KSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKA-KSPLKEDAKA 809
Query: 180 AEEN--KKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEE 237
E+ KKE+ + +EEEKP+ EV V+E +++EE + K + +
Sbjct: 810 PEKEIPKKEEVKSPVKEEEKPQ---------EVKVKEPPKKAEEEKAPATPKTEEKKDSK 860
Query: 238 PKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEA 297
++ ++E ++ ++ E + ++ E + EAE+++++ + + A + +A
Sbjct: 861 KEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDA 920
Query: 298 E--EKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEE 355
+ EK ++E +A+ +E + EK+ A ++ +EEK K EEK E
Sbjct: 921 KPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAK-------KPEEKPKTE- 972
Query: 356 RQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGE 407
+ KE++K ++E + +AE+ EK+ +QK +K E+ A ++ KG+
Sbjct: 973 -AKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEK---ATEDKAAKGK 1020
Score = 76.6 bits (187), Expect = 8e-14
Identities = 142/687 (20%), Positives = 257/687 (37%), Gaps = 74/687 (10%)
Query: 155 SRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEE 214
SR E+ +++ Y + N+ + E +++ R ++GE + E
Sbjct: 94 SRSEKEQLQALNDRFAGYIDKVRQLEAHNRSLEGEAAALRQQQAGRSAMGE-----LYER 148
Query: 215 KTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISH-HEKMEEEDKERAEAERARLE 273
+ E + + + GQ+ E+ E ++I+H +++++E ++R EAE A
Sbjct: 149 EVREMRGAVLRLGAARGQLRLEQ-------EHLLEDIAHVRQRLDDEARQREEAEAAARA 201
Query: 274 ----AEERERIKAEQDKKI--------------ADERARIEAEEKAAAQERERREAEERE 315
A+E E + + KK +E + + + + + + +AE R+
Sbjct: 202 LARFAQEAEAARVDLQKKAQALQEECGYLRRHHQEEVGELLGQIQGSGAAQAQMQAETRD 261
Query: 316 RMREEEKRAAEERQRIKE----EEKRAAEERQRIK----EEEKRAAEERQRIKEEEKRAA 367
++ + A E + E + +EE R++ E + + R +EE
Sbjct: 262 ALKCDVTSALREIRAQLEGHAVQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEITEY 321
Query: 368 EERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEG-----KW----- 417
+ +AR E E K + +Q E + Q ++ Q+++ KW
Sbjct: 322 RRQLQARTTELEALKSTKDSLERQRSELEDRHQADIASYQEAIQQLDAELRNTKWEMAAQ 381
Query: 418 -------VNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKE----EIKDE 466
+N K A + ++ +GEE L E P ++K E
Sbjct: 382 LREYQDLLNVKMALDIEIAAYRKLLEGEECRIGFGPIPFSLPEGLPKIPSVSTHIKVKSE 441
Query: 467 KIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEG 526
+ K E E+ ++ + T+V + E + K E G + +EAEG
Sbjct: 442 EKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGG-----EEEEAEG 496
Query: 527 APQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRR 586
+ EE E +S E+ K + + E EE K E K E+ +
Sbjct: 497 GEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEV--KSPEKAKSPA 554
Query: 587 KQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKI 646
K+E + EK K E + E A+ K ++ K P K +P K
Sbjct: 555 KEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKS 614
Query: 647 EERAEFLNKSVQKS-SGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVP 705
A+ K KS + VKS +A +K +++ + + E ++ P K + PV
Sbjct: 615 PAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKS---PVK 671
Query: 706 AEGVRNIKSMWEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKSPAPKPS 765
AE K+ SP A +P KE A S + E K+P+ KSP + +
Sbjct: 672 AEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKE-EAKSPEKAKSPVKEEA 730
Query: 766 DLRPGDVSSKRNLWEKQSVDKVTSPTK 792
S + E +S +K SP K
Sbjct: 731 KTPEKAKSPVKE--EAKSPEKAKSPEK 755
>gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]
Length = 1564
Score = 126 bits (317), Expect = 7e-29
Identities = 157/778 (20%), Positives = 317/778 (40%), Gaps = 87/778 (11%)
Query: 11 RRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNA 70
R RE+ R + ER + Q +D E R +R R++ R+++E E Q + ++
Sbjct: 392 RSPMREKGRHDHERTS-QSHDRRHERREDTRGKRDREKDSREEREYE-------QDQSSS 443
Query: 71 QNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQ-------KEFDP 123
++ D E + +G D + RRE R + ++++ E + + DP
Sbjct: 444 RDHRDDREPR--------DGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDP 495
Query: 124 TITDASLSLPSRRMQN--DTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAE 181
+ ++ R + DT E T EE + E + T ++ +N+ R
Sbjct: 496 RDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEI 555
Query: 182 ENKKEDKEKEEEEE--EKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPK 239
N + + + E EK RGS G +Q++ ET ++ +
Sbjct: 556 RNDRMGRSRGRVPELPEKGSRGSRG-SQIDSHSSNSNYHDSWET-----RSSYPERDRYP 609
Query: 240 QEEEREQGSD---EISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERA-RI 295
+ + R+Q D E H E+ +++ER + + + + R + E+D++ + R R+
Sbjct: 610 ERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRND-ELERDERREERRVDRV 668
Query: 296 EAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEE 355
+ A+ER+R +RER RE E+ ER++ +E E+ A ER+R +E+E+ +
Sbjct: 669 DDRRDERARERDRERERDRERERERERERDREREKERELERERAREREREREKERDRERD 728
Query: 356 RQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEG 415
R R + E+ ER R + E E+ + E ++ ++ E++ + + + E++ +
Sbjct: 729 RDRDHDRERERERERDREKEREREREERERERERERERERERERERERARERDKERERQR 788
Query: 416 KWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDK-PTFKKEEIKDEKIKKDK-- 472
W ++ K ++D+ + KRE+++ED+ P +E K +K +++
Sbjct: 789 DWEDKDKGRDDR-----------------REKREEIREDRNPRDGHDERKSKKRYRNEGS 831
Query: 473 -EPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVE 531
P++ K + S + + H+L + RP S+ Q
Sbjct: 832 PSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLL---SQVVRPQESRSLSPSHLTEDRQ-- 886
Query: 532 AGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEA 591
G+ EE R+ + S +E+ + K++ ++++ K+ E+ ++LE R +
Sbjct: 887 -GRWKEEDRKPERKESSRRYEEQELKEKVSSVD------KQREQTEILESSRMRAQDIIG 939
Query: 592 DRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAE 651
+ + E R +E +++ + +K ED + ++ + + G
Sbjct: 940 HHQSEDRETSDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNIETTSEDGQVF------- 992
Query: 652 FLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKP---AASDLPVPAEG 708
S +K KS + SK DS + +A + K P P +L G
Sbjct: 993 ----SPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQSKKKRGPRTPPITTKEELVEMCNG 1048
Query: 709 VRNI--KSMWEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKSPAPKP 764
I S ++ FS + P++ ++ T +P + P P P
Sbjct: 1049 KNGILEDSQKKEDTAFSDWSDEDVPDRTEVTEAEHTATATTPGSTPSPLSSLLPPPPP 1106
Score = 124 bits (310), Expect = 4e-28
Identities = 142/667 (21%), Positives = 280/667 (41%), Gaps = 46/667 (6%)
Query: 2 DDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQER----LRQKQEEE 57
+D +R+ + REE E ++ + + + DD E RR AR R LR ++
Sbjct: 418 EDTRGKRDREKDSREEREYEQDQSSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMR 477
Query: 58 SLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERR---QKRLQEA 114
++ D ++ P + T + + + + EE R + L+E
Sbjct: 478 DSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREE 537
Query: 115 LERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQK 174
R + + + ++ + + RM + E EK SR R ++ + +Y
Sbjct: 538 SSRTEIRNESRNESRSEIRNDRM--GRSRGRVPELPEKG-SRGSRGSQIDSHSSNSNYH- 593
Query: 175 NDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQIS 234
+ W + D+ E + ++ + S E + Q + + +
Sbjct: 594 DSWETRSSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDE 653
Query: 235 SEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIK-AEQDKKIADERA 293
E ++ EER + E+ E D+ER E +R R ERER + E+++++ ERA
Sbjct: 654 LERDERREERRVDRVDDRRDERARERDRER-ERDRERERERERERDREREKERELERERA 712
Query: 294 RIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAA 353
R E+ ++RER + +R RE E+ ER R KE E R EER+R +E E+
Sbjct: 713 REREREREKERDRERDRDRDHDRERERER----ERDREKERE-REREERERERERERERE 767
Query: 354 EERQRIKEEEKRAAEERQRARA-EEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQK 412
ER+R +E + +ER+R R E+++K + + +++ +++ E ++ + K +
Sbjct: 768 RERERERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYR 827
Query: 413 IEG--------KWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREK-------LQEDKP- 456
EG K E D + K + ++V +E L ED+
Sbjct: 828 NEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQG 887
Query: 457 TFKKEEIKDEKIK-----KDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFS 511
+K+E+ K E+ + +++E KE+V S +D+++ TE+ + + H ++
Sbjct: 888 RWKEEDRKPERKESSRRYEEQELKEKVSS-VDKQREQTEILESSRMRAQDIIGHHQSEDR 946
Query: 512 RPGGRASVDTKEAEGAPQVEAGKRLEE---LRRRRGETESEEFEKLKQKQQEAALELEEL 568
RA + K+ + K+ E+ + R ET SE+ + K+ + +E+
Sbjct: 947 ETSDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKK 1006
Query: 569 KKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRA--EAAEKRQKMPEDG 626
+KK + + +EE ++ +++ + K L E + E ++K++
Sbjct: 1007 RKKSKGDSDISDEEAAQQSKKKRGPRTPPITTKEELVEMCNGKNGILEDSQKKEDTAFSD 1066
Query: 627 LSDDKKP 633
SD+ P
Sbjct: 1067 WSDEDVP 1073
Score = 83.2 bits (204), Expect = 9e-16
Identities = 113/666 (16%), Positives = 265/666 (39%), Gaps = 75/666 (11%)
Query: 8 RELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVE 67
RE + KR+++ E ++ RN ++ R+ R R +E+E + ++
Sbjct: 86 RERMKNKRQDVDTEPQK----RNTEESSSPVRKESSRGRH------REKEDIKITKERTP 135
Query: 68 VNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQ--KRLQEALERQ------K 119
+ + +V E + + N + D + R++ +R+ K QE +E++ K
Sbjct: 136 ESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENMEKREEIIIKK 195
Query: 120 EFDPTITDASLS-LPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWR 178
E P + + LS PS R + + + +++ K + + + + + + Q+N
Sbjct: 196 EVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQ--QRNS-- 251
Query: 179 DAEENKKEDKEKEEEEEEKPKRGSIGEN-----QVEVMVEEKTTESQEETVVMSLKNGQI 233
++KK+ P+ ++G+ +V+ +EEKT + ++ + +
Sbjct: 252 KTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRG--RDFERQRE 309
Query: 234 SSEEPKQEEEREQGSDEIS--HHEKMEEE----DKERAEAERARLEAEERERIKAEQDKK 287
++P+ Q IS HH + + R R + +R ++
Sbjct: 310 KRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRR 369
Query: 288 IADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKE 347
A Q R + RE+ R + +R ++ R E + +R R
Sbjct: 370 SASPYPSHSLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDR--- 426
Query: 348 EEKRAAEERQRIKEE----------EKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKH 397
EK + EER+ +++ E R +R+ AR + ++ ++ + + + E +
Sbjct: 427 -EKDSREEREYEQDQSSSRDHRDDREPRDGRDRRDAR-DTRDRRELRDSRDMRDSREMRD 484
Query: 398 AMQETKIKGEKVEQKI----------EGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAK 447
++TK + + + EG+ + K+ + + + E+ ++ + +
Sbjct: 485 YSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIR 544
Query: 448 REKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTE 507
E E + EI+++++ + + E+ R +++ S + H T
Sbjct: 545 NESRNE-----SRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETR 599
Query: 508 NTFSRPGGRASVDTKEAEGAPQVEA--GKRLEELRRRRGETESEEF------EKLKQKQQ 559
+++ D ++ E G+R R R + S ++L++ ++
Sbjct: 600 SSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDER 659
Query: 560 EAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKR 619
++ + +R+ER + + E +R ++ E +R+ RE + +R + E+ER RA E+
Sbjct: 660 REERRVDRVDDRRDERARERDRERERDRERERERE-RERDREREKERELERERARERERE 718
Query: 620 QKMPED 625
++ D
Sbjct: 719 REKERD 724
Score = 56.6 bits (135), Expect = 9e-08
Identities = 71/378 (18%), Positives = 146/378 (38%), Gaps = 21/378 (5%)
Query: 262 KERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQ-ERERREAEERERMREE 320
+ER + +R ++ E ++R E + E +R EK + +ER E E + E
Sbjct: 86 RERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKEDIKITKERTPESEEENVEWE 145
Query: 321 EKRAAEERQRIKEE---EKRAAEERQRIKEEEKRAAEERQRIKEE---EKRAAEERQRAR 374
R + I + E +RQ+I+ E + +E +EE +K + E R++
Sbjct: 146 TNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENMEKREEIIIKKEVSPEVVRSK 205
Query: 375 AEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLK 434
+ + ++ K + + K V + + N K Q K
Sbjct: 206 LSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQS--------K 257
Query: 435 KQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQ 494
K+G + E + K +K ++KD +K ++ K+ + F +++ + +S
Sbjct: 258 KKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRGRDFERQREKRDKPRST 317
Query: 495 NGEFMTHK----LKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEE-LRRRRGETESE 549
+ H H+ ++ S + + + P + L LRR S
Sbjct: 318 SPAGQHHSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSH 377
Query: 550 EFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIE 609
++KQ +K R + + + ++R ++ E R R+ E+ R + E E
Sbjct: 378 SLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYE 437
Query: 610 RRRAEAAEKR-QKMPEDG 626
+ ++ + + R + P DG
Sbjct: 438 QDQSSSRDHRDDREPRDG 455
Score = 54.3 bits (129), Expect = 4e-07
Identities = 52/279 (18%), Positives = 112/279 (40%), Gaps = 14/279 (5%)
Query: 124 TITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEEN 183
+ + +++++ + +T N T E S + R +E+ ET + + R +
Sbjct: 1129 SFSTSAITISTSATPTNTTNN--TFANEDSHRKCHRTRVEKVETPHVTIEDAQHRKPMDQ 1186
Query: 184 KKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEE 243
K+ G + + +S + V+ S + ++ + E
Sbjct: 1187 KRSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDREKTKSLEITGE 1246
Query: 244 REQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAA 303
R+ D++ E +R ++ + R E D+++ ++ ++
Sbjct: 1247 RKSRIDQLKRGEPSRSTSSDRQDSR-----SHSSRRSSPESDRQVHSRSGSFDSRDRL-- 1299
Query: 304 QERERREAE-ERERMREEEKRAAEERQRIKE----EEKRAAEERQRIKEEEKRAAEERQR 358
QER+R E + ERER R + ++ +R K+ ++ ER+R +E +KR +R+R
Sbjct: 1300 QERDRYEHDRERERERRDTRQREWDRDADKDWPRNRDRDRLRERERERERDKRRDLDRER 1359
Query: 359 IKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKH 397
+ +R R R E +++E KR + E +H
Sbjct: 1360 ERLISDSVERDRDRDRDRTFESSQIESVKRCEAKLEGEH 1398
Score = 50.4 bits (119), Expect = 6e-06
Identities = 79/362 (21%), Positives = 133/362 (36%), Gaps = 48/362 (13%)
Query: 82 TTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDT 141
TT NT D + E +++A R+ P S SL S R
Sbjct: 1146 TTNNTFANEDSHRKCHRTRVEKVETPHVTIEDAQHRK----PMDQKRSSSLGSNR----- 1196
Query: 142 AENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEE-EKPKR 200
+ T +S S + + ++ K + RD E+ K + E + ++ KR
Sbjct: 1197 SNRSHTSGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDREKTKSLEITGERKSRIDQLKR 1256
Query: 201 GSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEE 260
G E + S + S + + S E +Q R D ++++E
Sbjct: 1257 G-----------EPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDS---RDRLQER 1302
Query: 261 DKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREE 320
D+ + ER R + R+R E D+ +K + R+R ERER RE
Sbjct: 1303 DRYEHDRERERERRDTRQR---EWDRDA----------DKDWPRNRDRDRLRERERERER 1349
Query: 321 EKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEK 380
+KR +R+R ER E+ +R R E + + +R A+ E E +
Sbjct: 1350 DKRRDLDRER----------ERLISDSVERDRDRDRDRTFESSQIESVKRCEAKLEGEHE 1399
Query: 381 AKVEEQKRNKQLEEKKHAMQET-KIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEE 439
+E R+ +K+ ++ ++G + K E E E KL A G
Sbjct: 1400 RDLESTSRDSLALDKERMDKDLGSVQGFEETNKSERTESLEAGDDESKLDDAHSLGSGAG 1459
Query: 440 KG 441
+G
Sbjct: 1460 EG 1461
Score = 45.8 bits (107), Expect = 2e-04
Identities = 48/210 (22%), Positives = 87/210 (41%), Gaps = 35/210 (16%)
Query: 2 DDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQ 61
D +E RE R++R+ + E + R+ D + R+R R +ER R++ + L +
Sbjct: 1303 DRYEHDRERERERRDTRQRE-----WDRDADKDWPRNRDRDRLRERERERERDKRRDLDR 1357
Query: 62 VTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEF 121
+++ ++ D + T ++Q+E KR + LE + E
Sbjct: 1358 ERERLISDSVERDRDRDRDRTFESSQIES-----------------VKRCEAKLEGEHER 1400
Query: 122 DPTITDA-SLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETET-----------VT 169
D T SL+L RM D + E+ KSE R E E + E+
Sbjct: 1401 DLESTSRDSLALDKERMDKDLGSVQGFEETNKSE-RTESLEAGDDESKLDDAHSLGSGAG 1459
Query: 170 KSYQKNDWRDAEENKKEDKEKEEEEEEKPK 199
+ Y+ + +E D EK E+++++ K
Sbjct: 1460 EGYEPISDDELDEILAGDAEKREDQQDEEK 1489
Score = 38.5 bits (88), Expect = 0.025
Identities = 87/513 (16%), Positives = 185/513 (36%), Gaps = 54/513 (10%)
Query: 136 RMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEE 195
R D E ++++ Q+R E + V K + R+ E+ K + E EE
Sbjct: 80 RPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKEDIKITKERTPESEE 139
Query: 196 EKPK---------RGSIGENQV-EVMVEEKTTESQEETVVMSLKN----------GQISS 235
E + G I + V E+ +E K + Q E + + +N ++S
Sbjct: 140 ENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENMEKREEIIIKKEVSP 199
Query: 236 EEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEA-------EERERIKAEQDKKI 288
E + + + S K + K + +++ R + +++ K Q KK
Sbjct: 200 EVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQSKKK 259
Query: 289 ADERAR----IEAEEKAAAQERERREAEER--ERMREEEKRAAE-ERQRIKEEEKRAAEE 341
I + + +E+ + ++R E+ R+ + R + ERQR K ++ R+
Sbjct: 260 GPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRGRDFERQREKRDKPRSTSP 319
Query: 342 --RQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAM 399
+ + + Q ++ + R++ + + R H++
Sbjct: 320 AGQHHSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSL 379
Query: 400 QETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFK 459
+ K + + +K + D +T+ + E+ + KR++ ++ + +
Sbjct: 380 SSPQRKQSPPRHRSPMR----EKGRHDHERTSQSHDRRHERREDTRGKRDREKDSRE--E 433
Query: 460 KEEIKDEKIKKDKEPKEEVKSFMDRKKG-FTEVKSQNGEFMTHKLKHTENTFSRPGGRAS 518
+E +D+ +D E + DR+ T + + + + +SR
Sbjct: 434 REYEQDQSSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSR------ 487
Query: 519 VDTKEAEGAPQVEAGKRLEELRRRRG-ETESEEFEKLKQKQQEAALELEELKKKREERRK 577
DTKE+ + + + R R G +T +E ++ + L E + E R
Sbjct: 488 -DTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRN- 545
Query: 578 VLEEEEQRRKQEEADRKLREEEEKRRLKEEIER 610
E + R + DR R L E+ R
Sbjct: 546 --ESRNESRSEIRNDRMGRSRGRVPELPEKGSR 576
Score = 38.1 bits (87), Expect = 0.032
Identities = 60/298 (20%), Positives = 120/298 (40%), Gaps = 35/298 (11%)
Query: 23 ERIAYQRNDDDEEEAARE--RRRRARQERLRQKQEEESLGQVT-DQVEVNAQNSVPDEEA 79
+R+ + + D E+ + E R++R ++L++ + S D +++ S P+ +
Sbjct: 1225 KRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDR 1284
Query: 80 KTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQN 139
+ + + + D L+ R E R++ + RQ+E+D DA P R ++
Sbjct: 1285 QVHSRSGSFDSRDR---LQERDRYEHDRERERERRDTRQREWD---RDADKDWPRNRDRD 1338
Query: 140 DTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPK 199
E E E+ ++ + E ++ S +++ RD D+ E + E K
Sbjct: 1339 RLRERE----RERERDKRRDLDRERERLISDSVERDRDRD------RDRTFESSQIESVK 1388
Query: 200 RGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEE 259
R E +E + E T SL + E ++ QG +E + E+
Sbjct: 1389 R-------CEAKLEGEHERDLESTSRDSL---ALDKERMDKDLGSVQGFEETNKSER--T 1436
Query: 260 EDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERM 317
E E + E +A E + I+D+ E +E A +R + ++ E+M
Sbjct: 1437 ESLEAGDDESKLDDAHSLGSGAGEGYEPISDD----ELDEILAGDAEKREDQQDEEKM 1490
Score = 35.4 bits (80), Expect = 0.21
Identities = 41/207 (19%), Positives = 80/207 (38%), Gaps = 16/207 (7%)
Query: 567 ELKKKREERRKVLEEEEQRRKQEEADRKLREEEE--KRRLKEEIERRRAEAAEKRQKMPE 624
+L+++ + +R+ ++ E Q+R EE+ +R+E + R KE+I+ + E ++ E
Sbjct: 84 DLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKEDIKITKERTPESEEENVE 143
Query: 625 -DGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYT 683
+ DD L +E + + + + + K + I+ K + E
Sbjct: 144 WETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENMEKREEIIIKKEVSPEVVR 203
Query: 684 SAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGTPNKETAGLKVGVS 743
S + + S + + + P + K K + SSP N +T
Sbjct: 204 SKLSPSPSLRKSSKSPKRKSSPKSSSASKKD--RKTSAVSSPLLDQQRNSKT-------- 253
Query: 744 SRINEWLTKTPDGNKSPAPKPSDLRPG 770
N+ K P P P P D+ G
Sbjct: 254 ---NQSKKKGPRTPSPPPPIPEDIALG 277
Score = 33.9 bits (76), Expect = 0.61
Identities = 28/144 (19%), Positives = 61/144 (42%), Gaps = 6/144 (4%)
Query: 470 KDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQ 529
+D+E + ++ +RK ++K T + + S D + +
Sbjct: 1233 RDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGS 1292
Query: 530 VEAGKRLEELRRRRGETESE-EFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQ 588
++ RL+E R + E E E +Q++ + + + + + +R + E E +R K+
Sbjct: 1293 FDSRDRLQERDRYEHDRERERERRDTRQREWDRDADKDWPRNRDRDRLRERERERERDKR 1352
Query: 589 EEADRKLREEEEKRRLKEEIERRR 612
+ DR E +R + + +ER R
Sbjct: 1353 RDLDR-----ERERLISDSVERDR 1371
Score = 31.2 bits (69), Expect = 3.9
Identities = 25/116 (21%), Positives = 55/116 (47%), Gaps = 6/116 (5%)
Query: 542 RRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQ--EEADRKLREEE 599
RR ES+ + ++ L+E + +R + E + R+++ +AD+
Sbjct: 1276 RRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQREWDRDADKDWPRNR 1335
Query: 600 EKRRLKE-EIER---RRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAE 651
++ RL+E E ER +R + +R+++ D + D+ + T + S ++ +R E
Sbjct: 1336 DRDRLRERERERERDKRRDLDRERERLISDSVERDRDRDRDRTFESSQIESVKRCE 1391
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 124 bits (312), Expect = 3e-28
Identities = 140/629 (22%), Positives = 274/629 (43%), Gaps = 90/629 (14%)
Query: 2 DDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQ 61
DD + E + + ++ + E +A + +++EEE + +++ Q+ +Q ++ +
Sbjct: 56 DDILKELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEE 115
Query: 62 VTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEF 121
+ D+ + + + P E + + + DD+ L + A+ + ++ + + E ++
Sbjct: 116 LEDKDSKSKKTAKPKVEMYSGS-----DDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDN 170
Query: 122 DPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQE--------RYEIEETETVTKSYQ 173
I + S S +++ E + K +K + + + + + + Q
Sbjct: 171 SKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQ 230
Query: 174 KNDWRDAEENKKEDKEK-------EEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVM 226
K + E KK D+EK E+EE E K+ + + + EE+T +S+ +
Sbjct: 231 KKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSK-----V 285
Query: 227 SLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDK 286
++ G I + E K E D E DK++ + ++ + E EE+E+ +K
Sbjct: 286 TVDTGVIPASEEKAETPTAAEDDN--------EGDKKKKDKKKKKGEKEEKEK-----EK 332
Query: 287 KIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIK 346
K +A ++A ++A A+ +E E ++RE E KR E + KEEE+ E+R+R K
Sbjct: 333 KKGPSKATVKAMQEALAKLKEEEERQKREE-EERIKRLEELEAKRKEEERLEQEKRERKK 391
Query: 347 EEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKR----NKQLEEKKHAMQET 402
++EK E ++R+K+E K + ++ ARA E K+ + + +K KK + E
Sbjct: 392 QKEK---ERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYED 448
Query: 403 KIKGEKVEQKIEGKWVNEKK---AQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFK 459
K K +K+ Q++E K V+E A + ++ V +K EE V+ + E+ ED
Sbjct: 449 K-KRKKIPQQLESKEVSESMELCAAVEVMEQGVPEK--EETPPPVEPEEEEDTEDAG--- 502
Query: 460 KEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASV 519
+ D + E E+V+ K EVK E
Sbjct: 503 ---LDDWEAMASDEETEKVEG----NKVHIEVKENPEE---------------------- 533
Query: 520 DTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQK---QQEAALELEELKKKREERR 576
E E + E + EE GE+E E ++ +K ++++ L++ K
Sbjct: 534 ---EEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSD 590
Query: 577 KVLEEEEQRRKQEEADRKLREEEEKRRLK 605
+ ++ R K+E A K + EKRRL+
Sbjct: 591 SEYDSDDDRTKEERAYDKAKRRIEKRRLE 619
Score = 107 bits (267), Expect = 4e-23
Identities = 138/649 (21%), Positives = 280/649 (43%), Gaps = 105/649 (16%)
Query: 15 REEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSV 74
++++ L+A + +E+ ++ + + ++E+ +Q +E+ + + +++ + AQ
Sbjct: 14 KDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIK 73
Query: 75 PDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPS 134
D E T + ++E F + +++ ++ K+ + FD
Sbjct: 74 ADRE----TVAVKPTENNEEEFTSKDKKKKGQKGKK--------QSFD------------ 109
Query: 135 RRMQNDTAENETTEKEEKSESRQ--ERYE-IEETETVTKSYQKNDWRDAEENKKEDKEKE 191
ND+ E E + + K ++ E Y ++ + K +K + + NKK D +E
Sbjct: 110 ---DNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEE 166
Query: 192 EEEEEKPKR--------GSIGENQVEVMVEEK------------TTESQEETVVMSLKNG 231
+E+ K + G G+ E + K ES E S K
Sbjct: 167 DEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIK 226
Query: 232 QISSEEP-KQEEEREQGSDEISHHEKMEE-EDKERAEAERARLEAEERERIKAEQDKKIA 289
++ ++ K+E ER++ +E + K++E E+ E + ++++ + +R+ + K+
Sbjct: 227 TVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVT 286
Query: 290 DERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEE 349
+ I A E+ A + E ++ ++++K+ E++ KE+EK+ + +K +
Sbjct: 287 VDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEE-KEKEKKKGPSKATVKAMQ 345
Query: 350 KRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKV 409
+ A+ ++ EEE++ EE +R + EE +AK +E++R LE++K ++ K K K
Sbjct: 346 EALAKLKE---EEERQKREEEERIKRLEELEAKRKEEER---LEQEKRERKKQKEKERKE 399
Query: 410 EQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIK 469
K EGK + K +E + + K + +G +V +K + L + +P + E+ K +KI
Sbjct: 400 RLKKEGKLLT-KSQREARARAEATLKLLQAQGVEVPSK-DSLPKKRPIY--EDKKRKKIP 455
Query: 470 KDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQ 529
+ E KE +S EV Q V KE E P
Sbjct: 456 QQLESKEVSESM--ELCAAVEVMEQG-----------------------VPEKE-ETPPP 489
Query: 530 VEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQE 589
VE E E+ E EA EE +K + + +E ++E
Sbjct: 490 VEP-------------EEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEE 536
Query: 590 EADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPED---GLSDDKKPFK 635
E + + +EE + +EE E +E E+ +K+ ++ G + DKKP K
Sbjct: 537 EEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSK 585
Score = 92.8 bits (229), Expect = 1e-18
Identities = 91/406 (22%), Positives = 193/406 (47%), Gaps = 47/406 (11%)
Query: 262 KERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEE 321
K++ ++E + + + + + AE + A + + + +E+++++ +E + ++E E
Sbjct: 4 KQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELE 63
Query: 322 KRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEE-- 379
+ + E Q IK + + A + EEE + +++++ ++ +K++ ++ E+++
Sbjct: 64 ELSL-EAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSK 122
Query: 380 -----KAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLK 434
K KVE + ++ ++ K K +K +K +G +E +++ K ++ +
Sbjct: 123 SKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINS 182
Query: 435 --KQGEEKGTKVQAKR--EKLQEDKP--------------------TFKKEEIKDEKIKK 470
+ G+E +Q+++ +K Q++KP KK E K+ + KK
Sbjct: 183 SGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKK 242
Query: 471 DKEPKEEVKSFMDRKKGFTEVKSQNG--------EFMTHKLKHTENTFSRPGGRASVDTK 522
E K +++ ++++ T K Q+ E T K K T +T P +T
Sbjct: 243 RDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETP 302
Query: 523 EAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEE--LKKKREERRKVLE 580
A E K+ ++ ++++GE E +E EK K + ++E K K EE R+ E
Sbjct: 303 TA-AEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKRE 361
Query: 581 EEEQRRKQEEADRKLREEE----EKRRLKEEIERRRAEAAEKRQKM 622
EEE+ ++ EE + K +EEE EKR K++ E+ R E +K K+
Sbjct: 362 EEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKL 407
Score = 92.8 bits (229), Expect = 1e-18
Identities = 100/468 (21%), Positives = 212/468 (45%), Gaps = 37/468 (7%)
Query: 213 EEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEE--EDKERAEAERA 270
+ K+ +S ++ + + +I +E+E ++ + +K ++ ED E E
Sbjct: 6 KNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEEL 65
Query: 271 RLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQR 330
LEA+ IKA+++ +A + EE + ++++ + +++ + + E++
Sbjct: 66 SLEAQG---IKADRET-VAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDS 121
Query: 331 IKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNK 390
++ + E +++ + ++ K + +++ ++ + +E+ K++E+ R
Sbjct: 122 KSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRIN 181
Query: 391 QLEEKKHAMQE--TKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKR 448
E E KG+K QK + N + ED + +K ++K K + +R
Sbjct: 182 SSGESGDESDEFLQSRKGQKKNQKNK-PGPNIESGNEDDDASFKIKTVAQKKAEKKERER 240
Query: 449 EKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTEN 508
+K E+K +K + K+E K+ ++ +S + E T K K T +
Sbjct: 241 KKRDEEKAKLRKLKEKEELETGKKDQSKQKES------------QRKFEEETVKSKVTVD 288
Query: 509 TFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEEL 568
T P +T A E K+ ++ ++++GE E +E EK K + ++E
Sbjct: 289 TGVIPASEEKAETPTA-AEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEA 347
Query: 569 KKKREERRKVLEEEEQRRKQEEADR--KLREEEEKRRLKEEIERRRAEAAEKRQKMPEDG 626
K L+EEE+R+K+EE +R +L E E KR+ +E +E+ + E ++++K ++
Sbjct: 348 LAK-------LKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKER 400
Query: 627 LSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSK 674
L KK K T S + RAE K +Q + GV+ + ++ K
Sbjct: 401 L---KKEGKLLTK--SQREARARAEATLKLLQ-AQGVEVPSKDSLPKK 442
Score = 83.2 bits (204), Expect = 9e-16
Identities = 86/433 (19%), Positives = 195/433 (45%), Gaps = 39/433 (9%)
Query: 7 RRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQV 66
++E R+KR+E + + ++ ++EE ++ +++Q+ ++K EEE+ V +V
Sbjct: 235 KKERERKKRDEEKAKLRKLK------EKEELETGKKDQSKQKESQRKFEEET---VKSKV 285
Query: 67 EVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTIT 126
V+ +P E K T T E D+E +++++++K +E E++K+ P+
Sbjct: 286 TVDT-GVIPASEEKAETP-TAAEDDNEGD----KKKKDKKKKKGEKEEKEKEKKKGPSKA 339
Query: 127 DASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKE 186
+ MQ A+ + E+ +K E + +EE E K ++ + E K++
Sbjct: 340 TV------KAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQK 393
Query: 187 DKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQ 246
+KE++E +++ K + + + E Q + V + K+ + + P E+++ +
Sbjct: 394 EKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDS-LPKKRPIYEDKKRK 452
Query: 247 GSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQER 306
+ +++ E + A E E+E + + ++ ++ A
Sbjct: 453 KIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASD 512
Query: 307 ERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRA 366
E E E ++ E K EE EEE+ E EE++ + EE + E E
Sbjct: 513 EETEKVEGNKVHIEVKENPEE-----EEEEEEEE------EEDEESEEEEEEEGESEGSE 561
Query: 367 AEERQRARAEEEEKAKVEEQKRNKQL-EEKKHAMQETKIKGE----KVEQKIEGKWV-NE 420
+E ++E++ K ++K +K++ + ++ + + K E K +++IE + + +
Sbjct: 562 GDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIEKRRLEHS 621
Query: 421 KKAQEDKLQTAVL 433
K +KL+ ++
Sbjct: 622 KNVNTEKLRAPII 634
Score = 61.6 bits (148), Expect = 3e-09
Identities = 73/360 (20%), Positives = 149/360 (41%), Gaps = 53/360 (14%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTD 64
+++++ +++K E+ E E+ + +A +E + ++E RQK+EEE + +
Sbjct: 313 KKKKDKKKKKGEKEEKEKEK--KKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLE 370
Query: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLE-RLARREERRQKRLQEALERQKEFDP 123
++E + E+ K + + E E +L + +R + EA + +
Sbjct: 371 ELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQG 430
Query: 124 TITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYE-----------IEETETVTKSY 172
+ SLP +R + + + ++ +S+ E E + E E
Sbjct: 431 VEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPV 490
Query: 173 QKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQ 232
+ + D E+ +D E +EE K + N+V + V+E E +EE +
Sbjct: 491 EPEEEEDTEDAGLDDWEAMASDEETEK---VEGNKVHIEVKENPEEEEEEE--------E 539
Query: 233 ISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADER 292
E+ + EEE E EE + E +E + E+D+K++DE+
Sbjct: 540 EEEEDEESEEEEE------------EEGESEGSEGD--------------EEDEKVSDEK 573
Query: 293 ARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRA 352
+ +K ++E + + R +E+RA ++ +R EKR E + + E+ RA
Sbjct: 574 DSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKR--RIEKRRLEHSKNVNTEKLRA 631
Score = 32.3 bits (72), Expect = 1.8
Identities = 23/119 (19%), Positives = 55/119 (46%), Gaps = 5/119 (4%)
Query: 1 MDDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLG 60
+DD+E ++ E + +++EEE E + +E + + E S G
Sbjct: 503 LDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEG 562
Query: 61 QVTDQV---EVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERR--QKRLQEA 114
D+ E ++ ++ + +K +++++ + DD+ ER + +RR ++RL+ +
Sbjct: 563 DEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIEKRRLEHS 621
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 118 bits (295), Expect = 2e-26
Identities = 129/550 (23%), Positives = 248/550 (45%), Gaps = 79/550 (14%)
Query: 230 NGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIA 289
NG + S + QEEE ++ + EDK +A ER +E E+R + EQ ++ A
Sbjct: 341 NGTLPSYQKMQEEEPQKKLP-------VTFEDKRKANYERGNMELEKRRQALMEQQQREA 393
Query: 290 DERARIEAEEKAAAQERERREAEERE--RMREEEKRAAEERQ--RIKEEEKRAAEERQRI 345
+ +A+ E EE ER++RE +E+E + E EKR ++R+ R +EEE+R ER
Sbjct: 394 ERKAQKEKEE----WERKQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIER--- 446
Query: 346 KEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIK 405
+E K+ E ++R++ E R E + E+EE ++ +K+N LE + + +I
Sbjct: 447 REAAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQIS 506
Query: 406 GEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTF----KKE 461
G + ++ K Q K + VL KQ + + +++ +++LQE + ++
Sbjct: 507 GRLQDVRL--------KKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEK 558
Query: 462 EIKDEKIK----------------KDKEPKEE----VKSFMDRKKGFTEVKSQNGEFMTH 501
++ +E+IK K KEE +K +D + T K + +
Sbjct: 559 QLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNN 618
Query: 502 KLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEA 561
+LK T++ K + KRLE +++++ E E+ K KQ +
Sbjct: 619 QLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAAR----KAKQGKE 674
Query: 562 ALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAA----E 617
L E L+K+ EE++K L+EE+ + K +E +RK E++ K + + E ++ E A
Sbjct: 675 NLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVN 734
Query: 618 KRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERA----EFLNKSVQKSSG------VKSTH 667
R P + + D+ F G ++++E+ +L S Q + G V+
Sbjct: 735 YRALYPFEARNHDEMSFN----SGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMP 790
Query: 668 QAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRN-------IKSMWEKGN 720
+ + + + + ++ ++P +S+ P +N + + W+K +
Sbjct: 791 SSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKS 850
Query: 721 VFSSPTAAGT 730
F+ + G+
Sbjct: 851 AFTRTVSPGS 860
Score = 72.4 bits (176), Expect = 2e-12
Identities = 89/384 (23%), Positives = 169/384 (44%), Gaps = 29/384 (7%)
Query: 4 FERRRELRRQKREEMRLEAERIAY--QRNDDDEEEAARERRRRARQERLRQKQEEESLGQ 61
FE +R+ + R M LE R A Q+ + E +A +E+ R++R Q+QE + +
Sbjct: 363 FEDKRKANYE-RGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLE 421
Query: 62 VTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEF 121
+ ++E + EE + + E RL RRQ+ L + Q+E
Sbjct: 422 LEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEEI 481
Query: 122 DPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAE 181
+ L S++ K ++ R + +++ T+ + D E
Sbjct: 482 --------VRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLE 533
Query: 182 ENKKEDKEKEEEEEEKPKRGSIGENQ-VEVMVEEKTTESQEETVVMSLKNGQISSEEPKQ 240
+ + ++E +E + + E Q + ++ + ++ V L + EE Q
Sbjct: 534 IMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQ 593
Query: 241 EEEREQGSDEISHHEKMEEEDKERAEAERAR-------LEAEERERIKAEQDKKIADERA 293
+ + + E K+ E D + + R L E+ +IK ++ K+I ER
Sbjct: 594 RLKEQLDALEKETASKLSEMDSFNNQLKELRETYNTQQLALEQLYKIKRDKLKEI--ERK 651
Query: 294 RIEAEEKAAAQERERREAEE-RERMREEEKRAAEERQRIKEEEKRAAEERQRIK-EEEKR 351
R+E +K ++ R+A++ +E + +E R EE E++KR EE+ + K +EE+R
Sbjct: 652 RLELMQKKKLEDEAARKAKQGKENLWKENLRKEEE-----EKQKRLQEEKTQEKIQEEER 706
Query: 352 AAEERQRIKEEEKRAAEERQRARA 375
AEE+QR K+++ AEE++R A
Sbjct: 707 KAEEKQR-KDKDTLKAEEKKRETA 729
Score = 68.9 bits (167), Expect = 2e-11
Identities = 92/439 (20%), Positives = 188/439 (42%), Gaps = 68/439 (15%)
Query: 131 SLPS-RRMQNDTAENE---TTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKE 186
+LPS ++MQ + + + T E + K+ + E+E+ Q+ + + +KE
Sbjct: 343 TLPSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKE 402
Query: 187 DKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQ 246
+ E+++ E ++ + + Q+E+ EK E Q E Q E K E RE
Sbjct: 403 EWERKQRELQEQE----WKKQLEL---EKRLEKQREL------ERQREEERRKDIERREA 449
Query: 247 GSDEISHHEKMEEEDKERAE-AERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQE 305
E+ ++E E R E + E EE R+ +++ + A ++ + +
Sbjct: 450 AKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRL 509
Query: 306 RERREAEERERMREE--EKRAAEERQRIKEEEKRAAE----------ERQRIKEEEKR-- 351
++ R ++ ++ E +K+ E IK+ ++ E E+Q + E K
Sbjct: 510 QDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQ 569
Query: 352 ---------AAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKR-NKQLEEKKHAM-- 399
+ ++ +++EE + Q E+E +K+ E N QL+E +
Sbjct: 570 FSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKELRETYNT 629
Query: 400 ------QETKIKGEKVEQ------------KIEGKWVNEKKAQEDKLQTAVLKKQGEEKG 441
Q KIK +K+++ K+E + + K ++ L L+K+ EEK
Sbjct: 630 QQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQ 689
Query: 442 TKVQAKR--EKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFM 499
++Q ++ EK+QE++ ++++ KD+ K +E K E S + + +++N + M
Sbjct: 690 KRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEM 749
Query: 500 THK----LKHTENTFSRPG 514
+ ++ E T PG
Sbjct: 750 SFNSGDIIQVDEKTVGEPG 768
Score = 35.4 bits (80), Expect = 0.21
Identities = 48/199 (24%), Positives = 84/199 (42%), Gaps = 29/199 (14%)
Query: 83 TTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTA 142
T NTQ ++ ++R +E R KRL E ++++K + D + + +N
Sbjct: 626 TYNTQQLALEQLYKIKRDKLKEIER-KRL-ELMQKKK-----LEDEAARKAKQGKENLWK 678
Query: 143 ENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGS 202
EN E+EEK + QE E+ + + R AEE +++DK+ + EE+K + S
Sbjct: 679 ENLRKEEEEKQKRLQEEKTQEKIQ--------EEERKAEEKQRKDKDTLKAEEKKRETAS 730
Query: 203 IGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEE---------REQGSDEISH 253
+ N + E + MS +G I + K E G ++
Sbjct: 731 VLVNYRALYPFEARNHDE-----MSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNY 785
Query: 254 HEKMEEEDKERAEAERARL 272
EKM + E+A + + L
Sbjct: 786 VEKMPSSENEKAVSPKKAL 804
>gi|239745299 PREDICTED: hypothetical protein [Homo sapiens]
Length = 523
Score = 117 bits (294), Expect = 3e-26
Identities = 107/435 (24%), Positives = 210/435 (48%), Gaps = 50/435 (11%)
Query: 104 EERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIE 163
E R E LE Q + D+S ++ S+ +N + T+++E+K +EI
Sbjct: 76 EGRASSTTLEDLESQYQELAVALDSSSAIISQLTENINSLVRTSKEEKK-------HEIH 128
Query: 164 ETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEE-----KTTE 218
+ + +S K K + E G ++VE + +E K E
Sbjct: 129 LVQKLGRSLFKL--------------KNQTAEPLAPEPPAGPSKVEQLQDETNHLRKELE 174
Query: 219 SQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERE 278
S + ++N Q+ S +++EER + +E ++ E+++ E E E EER
Sbjct: 175 SVGRQLQAEVENNQMLSLLNRRQEERLREQEE-----RLREQEERLREQEERLCEQEERL 229
Query: 279 RIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRA 338
R EQ++++ ++ R+ E++ +E E R E+ ER+ E+E+R E+ +R+ E+E+R
Sbjct: 230 R---EQEERLREQEERL-CEQEERLREHEERLCEQEERLCEQEERLREQEERLHEQEERL 285
Query: 339 AEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHA 398
E+ +R++E+E+R E+ +R++E+E+R E+ +R R +EE + E+ ++L E+
Sbjct: 286 CEQEERLREQEERLCEQEERLREQEERLCEQEERLREQEERLCEQEKLPGQERLLEEVEK 345
Query: 399 MQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTF 458
+ E + + E+ E+ +E + + E+ E+ L+ L++Q E ++E LQE +
Sbjct: 346 LLEQERRQEEQERLLERERLLEE--VEELLEQERLRQQDERLW-----QQETLQELERLR 398
Query: 459 KKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRAS 518
+ E + + + E + E +S GF E+ ++N T +L+ + GG
Sbjct: 399 ELERMLELGWEALYEQRAEPRS------GFEELNNENKS--TLQLEQQVKELKKSGGAEE 450
Query: 519 VDTKEAEGAPQVEAG 533
E+ A + AG
Sbjct: 451 PRGSESAAAARPVAG 465
Score = 73.9 bits (180), Expect = 5e-13
Identities = 84/346 (24%), Positives = 152/346 (43%), Gaps = 51/346 (14%)
Query: 34 EEEAARERRRRARQERLRQKQEEESLG-QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDD 92
E A + + + E ++E ES+G Q+ +VE N S+ + + + +
Sbjct: 151 EPPAGPSKVEQLQDETNHLRKELESVGRQLQAEVENNQMLSLLNRRQEERLREQEERLRE 210
Query: 93 EAAFLERLARREER---RQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEK 149
+ ERL +EER +++RL+E ER +E E E+
Sbjct: 211 QE---ERLREQEERLCEQEERLREQEERLRE---------------------QEERLCEQ 246
Query: 150 EEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVE 209
EE+ +ER E+ E + + Q+ R+ EE E +E+ E+EE+ + E +
Sbjct: 247 EERLREHEERL-CEQEERLCE--QEERLREQEERLHEQEERLCEQEER-----LREQEER 298
Query: 210 VMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAER 269
+ +E+ QEE + E +++EER +++ E++ EE ++ E ER
Sbjct: 299 LCEQEERLREQEERLCE-------QEERLREQEERLCEQEKLPGQERLLEEVEKLLEQER 351
Query: 270 ARLEAE---ERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAE 326
+ E E ERER+ E ++ + ER R + +E+ QE +E ER+RE E+
Sbjct: 352 RQEEQERLLERERLLEEVEELLEQERLR-QQDERLWQQE----TLQELERLRELERMLEL 406
Query: 327 ERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQR 372
+ + E+ + + E K + Q++KE +K E R
Sbjct: 407 GWEALYEQRAEPRSGFEELNNENKSTLQLEQQVKELKKSGGAEEPR 452
Score = 55.8 bits (133), Expect = 1e-07
Identities = 73/348 (20%), Positives = 131/348 (37%), Gaps = 68/348 (19%)
Query: 8 RELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVE 67
R+L+ + L + ++EE RE+ R R++ R ++EE L + +++
Sbjct: 178 RQLQAEVENNQMLSLLNRRQEERLREQEERLREQEERLREQEERLCEQEERLREQEERLR 237
Query: 68 VNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREER---RQKRLQEALERQKEFDPT 124
+ EE ERL +EER +++RL+E ER E
Sbjct: 238 EQEERLCEQEERLREHE-------------ERLCEQEERLCEQEERLREQEERLHE---- 280
Query: 125 ITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENK 184
E E+EE+ ++ER E+ E + + Q+ + EE
Sbjct: 281 -----------------QEERLCEQEERLREQEERL-CEQEERLRE--QEERLCEQEERL 320
Query: 185 KEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEER 244
+E +E+ E+E+ P + + E +++ +E+ E QE
Sbjct: 321 REQEERLCEQEKLPGQERLLEEVEKLLEQERRQEEQE----------------------- 357
Query: 245 EQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQ 304
+ E++ EE +E E ER R + E + + Q+ + E R+ A
Sbjct: 358 -----RLLERERLLEEVEELLEQERLRQQDERLWQQETLQELERLRELERMLELGWEALY 412
Query: 305 ERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRA 352
E+ E + E K + Q++KE +K E R E A
Sbjct: 413 EQRAEPRSGFEELNNENKSTLQLEQQVKELKKSGGAEEPRGSESAAAA 460
Score = 53.1 bits (126), Expect = 1e-06
Identities = 83/354 (23%), Positives = 158/354 (44%), Gaps = 46/354 (12%)
Query: 393 EEKKHAMQET--------KIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKV 444
EEKKH + K+K + E K ++ + +T L+K+ E G ++
Sbjct: 121 EEKKHEIHLVQKLGRSLFKLKNQTAEPLAPEPPAGPSKVEQLQDETNHLRKELESVGRQL 180
Query: 445 QAKRE---------KLQEDKPTFKKEEIKD--EKIKKDKEPK-EEVKSFMDRKKGFTEVK 492
QA+ E + QE++ ++E +++ E++++ +E E+ + ++++ E +
Sbjct: 181 QAEVENNQMLSLLNRRQEERLREQEERLREQEERLREQEERLCEQEERLREQEERLREQE 240
Query: 493 SQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQV-EAGKRL---EELRRRRGETES 548
+ E +H E + + + E ++ E +RL EE R + E
Sbjct: 241 ERLCEQEERLREHEERLCEQEERLCEQEERLREQEERLHEQEERLCEQEERLREQEERLC 300
Query: 549 EEFEKLKQKQQEAALELEELKKKREER----------RKVLEEEE----QRRKQEEADRK 594
E+ E+L++ Q+E E EE +++EER ++LEE E Q R+QEE +R
Sbjct: 301 EQEERLRE-QEERLCEQEERLREQEERLCEQEKLPGQERLLEEVEKLLEQERRQEEQERL 359
Query: 595 LREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDK-KPFKCFTPKGSSLKIEERAEFL 653
L E ++E +E+ R ++R E ++ + + G E+RAE
Sbjct: 360 LERERLLEEVEELLEQERLRQQDERLWQQETLQELERLRELERMLELGWEALYEQRAEPR 419
Query: 654 NKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIE--GTKSAKPTKPAASDLPVP 705
+ + ++ KST Q + + L++ A E G++SA +P A PVP
Sbjct: 420 SGFEELNNENKSTLQ---LEQQVKELKKSGGAEEPRGSESAAAARPVAG-APVP 469
Score = 34.3 bits (77), Expect = 0.46
Identities = 34/128 (26%), Positives = 61/128 (47%), Gaps = 14/128 (10%)
Query: 516 RASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREER 575
R S + K+ E + G+ L +L+ + E + E K ++ E L+K+ E
Sbjct: 117 RTSKEEKKHEIHLVQKLGRSLFKLKNQTAEPLAPEPPAGPSKVEQLQDETNHLRKELESV 176
Query: 576 RKVLEEEEQ--------RRKQEEADRKLREEEEKRRLKEEIERRRAE---AAEKRQKMPE 624
+ L+ E + R+QEE +LRE+EE+ R +EE R + E E+R + E
Sbjct: 177 GRQLQAEVENNQMLSLLNRRQEE---RLREQEERLREQEERLREQEERLCEQEERLREQE 233
Query: 625 DGLSDDKK 632
+ L + ++
Sbjct: 234 ERLREQEE 241
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.301 0.120 0.306
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,357,458
Number of Sequences: 37866
Number of extensions: 1856813
Number of successful extensions: 135275
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1689
Number of HSP's successfully gapped in prelim test: 1603
Number of HSP's that attempted gapping in prelim test: 13190
Number of HSP's gapped (non-prelim): 31821
length of query: 793
length of database: 18,247,518
effective HSP length: 110
effective length of query: 683
effective length of database: 14,082,258
effective search space: 9618182214
effective search space used: 9618182214
T: 11
A: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.