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Search of human proteins with 42821112
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|42821112 serine/threonine protein kinase pim-2 [Homo
sapiens]
(311 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|42821112 serine/threonine protein kinase pim-2 [Homo sapiens] 658 0.0
gi|224591416 serine/threonine protein kinase pim-3 [Homo sapiens] 355 4e-98
gi|4505811 non-specific serine/threonine protein kinase [Homo sa... 337 6e-93
gi|254028240 MAP/microtubule affinity-regulating kinase 2 isofor... 146 3e-35
gi|254028237 MAP/microtubule affinity-regulating kinase 2 isofor... 146 3e-35
gi|254028234 MAP/microtubule affinity-regulating kinase 2 isofor... 146 3e-35
gi|254028232 MAP/microtubule affinity-regulating kinase 2 isofor... 146 3e-35
gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform... 146 3e-35
gi|24308326 BR serine/threonine kinase 1 [Homo sapiens] 146 3e-35
gi|116256471 SNF1-like kinase [Homo sapiens] 145 6e-35
gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s... 145 6e-35
gi|156105707 SNF related kinase [Homo sapiens] 142 3e-34
gi|156105705 SNF related kinase [Homo sapiens] 142 3e-34
gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo ... 142 3e-34
gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor... 140 2e-33
gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor... 140 2e-33
gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor... 140 2e-33
gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform... 140 2e-33
gi|35038528 PAS domain containing serine/threonine kinase [Homo ... 140 2e-33
gi|116089335 BR serine/threonine kinase 2 [Homo sapiens] 139 2e-33
gi|38569460 SNF1-like kinase 2 [Homo sapiens] 135 4e-32
gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens] 132 3e-31
gi|23503303 serine/threonine-protein kinase NIM1 [Homo sapiens] 131 7e-31
gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic sub... 129 3e-30
gi|7657214 hormonally upregulated Neu-associated kinase [Homo sa... 127 1e-29
gi|16418343 testis-specific serine kinase 3 [Homo sapiens] 127 2e-29
gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens] 126 2e-29
gi|7662170 AMPK-related protein kinase 5 [Homo sapiens] 124 8e-29
gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens] 124 1e-28
gi|46877068 AMP-activated protein kinase alpha 2 catalytic subun... 123 2e-28
>gi|42821112 serine/threonine protein kinase pim-2 [Homo sapiens]
Length = 311
Score = 658 bits (1697), Expect = 0.0
Identities = 311/311 (100%), Positives = 311/311 (100%)
Query: 1 MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAI 60
MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAI
Sbjct: 1 MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAI 60
Query: 61 KVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPL 120
KVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPL
Sbjct: 61 KVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPL 120
Query: 121 PAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKL 180
PAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKL
Sbjct: 121 PAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKL 180
Query: 181 IDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFER 240
IDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFER
Sbjct: 181 IDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFER 240
Query: 241 DQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKG 300
DQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKG
Sbjct: 241 DQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKG 300
Query: 301 GPAPLAWSLLP 311
GPAPLAWSLLP
Sbjct: 301 GPAPLAWSLLP 311
>gi|224591416 serine/threonine protein kinase pim-3 [Homo sapiens]
Length = 326
Score = 355 bits (910), Expect = 4e-98
Identities = 176/275 (64%), Positives = 206/275 (74%), Gaps = 1/275 (0%)
Query: 20 PGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVT 79
P D+E+FE Y++G +LG GGFGTV+AG R+ D L VA+K + + RV W L + T
Sbjct: 28 PAKADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGA-T 86
Query: 80 CPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGP 139
PLEV LL KVGA GG GVIRLLDWFE +GF+LVLERP PAQDLFD+ITE+G L E
Sbjct: 87 VPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPL 146
Query: 140 SRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDG 199
+R FF QV+AA++HCHS GVVHRDIKDEN+L+DLR G KLIDFGSGALL D YTDFDG
Sbjct: 147 ARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDG 206
Query: 200 TRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDC 259
TRVYSPPEWI H+YH ATVWSLG+LLYDMVCGDIPFE+D+EIL L F VSP+C
Sbjct: 207 TRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPEC 266
Query: 260 CALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVP 294
LIR CL+ +PS RPSL++I PWM VP
Sbjct: 267 QQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGVP 301
>gi|4505811 non-specific serine/threonine protein kinase [Homo
sapiens]
Length = 313
Score = 337 bits (865), Expect = 6e-93
Identities = 167/286 (58%), Positives = 206/286 (72%), Gaps = 5/286 (1%)
Query: 22 GKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCP 81
GK++E E++Y++GPLLG GGFG+V++G R++D L VAIK + ++R+ W L + P
Sbjct: 28 GKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVP 87
Query: 82 LEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSR 141
+EV LL KV +G GVIRLLDWFE + F+L+LERP P QDLFD+ITE+G L E +R
Sbjct: 88 MEVVLLKKVSSG--FSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELAR 145
Query: 142 CFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTR 201
FF QV+ A++HCH+ GV+HRDIKDENILIDL RG KLIDFGSGALL D YTDFDGTR
Sbjct: 146 SFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTR 205
Query: 202 VYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCA 261
VYSPPEWI H+YH A VWSLGILLYDMVCGDIPFE D+EI+ ++ F VS +C
Sbjct: 206 VYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQH 265
Query: 262 LIRRCLAPKPSSRPSLEEILLDPWMQ---TPAEDVPLNPSKGGPAP 304
LIR CLA +PS RP+ EEI PWMQ P E ++ P P
Sbjct: 266 LIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGP 311
>gi|254028240 MAP/microtubule affinity-regulating kinase 2 isoform f
[Homo sapiens]
Length = 709
Score = 146 bits (368), Expect = 3e-35
Identities = 94/282 (33%), Positives = 145/282 (51%), Gaps = 19/282 (6%)
Query: 24 DREAFEAEYRLGPLLGKGGFGTV-FAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPL 82
D + YRL +GKG F V A H LT + +VA+K+I + ++ S S+
Sbjct: 45 DEQPHIGNYRLLKTIGKGNFAKVKLARHILTGK-EVAVKIIDKTQLN-----SSSLQKLF 98
Query: 83 EVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRC 142
+ KV HP +++L + ET++ LV+E ++FDY+ G + E +R
Sbjct: 99 REVRIMKVL---NHPNIVKLFEVIETEKTLYLVMEYA-SGGEVFDYLVAHGRMKEKEARA 154
Query: 143 FFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFG-SGALLHDEPYTDFDGTR 201
F Q+V+A+Q+CH + +VHRD+K EN+L+D K+ DFG S F G+
Sbjct: 155 KFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMN-IKIADFGFSNEFTFGNKLDTFCGSP 213
Query: 202 VYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPF------ERDQEILEAELHFPAHV 255
Y+ PE +Y VWSLG++LY +V G +PF E + +L + P ++
Sbjct: 214 PYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYM 273
Query: 256 SPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNP 297
S DC L+++ L PS R +LE+I+ D WM ED L P
Sbjct: 274 STDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKP 315
>gi|254028237 MAP/microtubule affinity-regulating kinase 2 isoform e
[Homo sapiens]
Length = 719
Score = 146 bits (368), Expect = 3e-35
Identities = 94/282 (33%), Positives = 145/282 (51%), Gaps = 19/282 (6%)
Query: 24 DREAFEAEYRLGPLLGKGGFGTV-FAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPL 82
D + YRL +GKG F V A H LT + +VA+K+I + ++ S S+
Sbjct: 45 DEQPHIGNYRLLKTIGKGNFAKVKLARHILTGK-EVAVKIIDKTQLN-----SSSLQKLF 98
Query: 83 EVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRC 142
+ KV HP +++L + ET++ LV+E ++FDY+ G + E +R
Sbjct: 99 REVRIMKVL---NHPNIVKLFEVIETEKTLYLVMEYA-SGGEVFDYLVAHGRMKEKEARA 154
Query: 143 FFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFG-SGALLHDEPYTDFDGTR 201
F Q+V+A+Q+CH + +VHRD+K EN+L+D K+ DFG S F G+
Sbjct: 155 KFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMN-IKIADFGFSNEFTFGNKLDTFCGSP 213
Query: 202 VYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPF------ERDQEILEAELHFPAHV 255
Y+ PE +Y VWSLG++LY +V G +PF E + +L + P ++
Sbjct: 214 PYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYM 273
Query: 256 SPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNP 297
S DC L+++ L PS R +LE+I+ D WM ED L P
Sbjct: 274 STDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKP 315
>gi|254028234 MAP/microtubule affinity-regulating kinase 2 isoform d
[Homo sapiens]
Length = 788
Score = 146 bits (368), Expect = 3e-35
Identities = 94/282 (33%), Positives = 145/282 (51%), Gaps = 19/282 (6%)
Query: 24 DREAFEAEYRLGPLLGKGGFGTV-FAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPL 82
D + YRL +GKG F V A H LT + +VA+K+I + ++ S S+
Sbjct: 45 DEQPHIGNYRLLKTIGKGNFAKVKLARHILTGK-EVAVKIIDKTQLN-----SSSLQKLF 98
Query: 83 EVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRC 142
+ KV HP +++L + ET++ LV+E ++FDY+ G + E +R
Sbjct: 99 REVRIMKVL---NHPNIVKLFEVIETEKTLYLVMEYA-SGGEVFDYLVAHGRMKEKEARA 154
Query: 143 FFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFG-SGALLHDEPYTDFDGTR 201
F Q+V+A+Q+CH + +VHRD+K EN+L+D K+ DFG S F G+
Sbjct: 155 KFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMN-IKIADFGFSNEFTFGNKLDTFCGSP 213
Query: 202 VYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPF------ERDQEILEAELHFPAHV 255
Y+ PE +Y VWSLG++LY +V G +PF E + +L + P ++
Sbjct: 214 PYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYM 273
Query: 256 SPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNP 297
S DC L+++ L PS R +LE+I+ D WM ED L P
Sbjct: 274 STDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKP 315
>gi|254028232 MAP/microtubule affinity-regulating kinase 2 isoform c
[Homo sapiens]
Length = 724
Score = 146 bits (368), Expect = 3e-35
Identities = 94/282 (33%), Positives = 145/282 (51%), Gaps = 19/282 (6%)
Query: 24 DREAFEAEYRLGPLLGKGGFGTV-FAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPL 82
D + YRL +GKG F V A H LT + +VA+K+I + ++ S S+
Sbjct: 45 DEQPHIGNYRLLKTIGKGNFAKVKLARHILTGK-EVAVKIIDKTQLN-----SSSLQKLF 98
Query: 83 EVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRC 142
+ KV HP +++L + ET++ LV+E ++FDY+ G + E +R
Sbjct: 99 REVRIMKVL---NHPNIVKLFEVIETEKTLYLVMEYA-SGGEVFDYLVAHGRMKEKEARA 154
Query: 143 FFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFG-SGALLHDEPYTDFDGTR 201
F Q+V+A+Q+CH + +VHRD+K EN+L+D K+ DFG S F G+
Sbjct: 155 KFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMN-IKIADFGFSNEFTFGNKLDTFCGSP 213
Query: 202 VYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPF------ERDQEILEAELHFPAHV 255
Y+ PE +Y VWSLG++LY +V G +PF E + +L + P ++
Sbjct: 214 PYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYM 273
Query: 256 SPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNP 297
S DC L+++ L PS R +LE+I+ D WM ED L P
Sbjct: 274 STDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKP 315
>gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform a
[Homo sapiens]
Length = 745
Score = 146 bits (368), Expect = 3e-35
Identities = 94/282 (33%), Positives = 145/282 (51%), Gaps = 19/282 (6%)
Query: 24 DREAFEAEYRLGPLLGKGGFGTV-FAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPL 82
D + YRL +GKG F V A H LT + +VA+K+I + ++ S S+
Sbjct: 12 DEQPHIGNYRLLKTIGKGNFAKVKLARHILTGK-EVAVKIIDKTQLN-----SSSLQKLF 65
Query: 83 EVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRC 142
+ KV HP +++L + ET++ LV+E ++FDY+ G + E +R
Sbjct: 66 REVRIMKVL---NHPNIVKLFEVIETEKTLYLVMEYA-SGGEVFDYLVAHGRMKEKEARA 121
Query: 143 FFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFG-SGALLHDEPYTDFDGTR 201
F Q+V+A+Q+CH + +VHRD+K EN+L+D K+ DFG S F G+
Sbjct: 122 KFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMN-IKIADFGFSNEFTFGNKLDTFCGSP 180
Query: 202 VYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPF------ERDQEILEAELHFPAHV 255
Y+ PE +Y VWSLG++LY +V G +PF E + +L + P ++
Sbjct: 181 PYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYM 240
Query: 256 SPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNP 297
S DC L+++ L PS R +LE+I+ D WM ED L P
Sbjct: 241 STDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKP 282
>gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]
Length = 778
Score = 146 bits (368), Expect = 3e-35
Identities = 94/279 (33%), Positives = 146/279 (52%), Gaps = 21/279 (7%)
Query: 16 PTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLS 75
P P P + YRL LGKG G V G +VAIK++ R + LS
Sbjct: 18 PHPHPHPPQHAQYVGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREK------LS 71
Query: 76 DSVTCPLE--VALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKG 133
+SV +E +A+L + HP V++L D +E ++ LVLE + +LFDY+ +KG
Sbjct: 72 ESVLMKVEREIAILKLIE----HPHVLKLHDVYENKKYLYLVLEH-VSGGELFDYLVKKG 126
Query: 134 PLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGAL-LHDE 192
L +R FF Q+V+A+ CHS + HRD+K EN+L+D + ++ DFG +L + D
Sbjct: 127 RLTPKEARKFFRQIVSALDFCHSYSICHRDLKPENLLLD-EKNNIRIADFGMASLQVGDS 185
Query: 193 PYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERD------QEILE 246
G+ Y+ PE I +Y A +WS G++L+ ++ G +PF+ D +++
Sbjct: 186 LLETSCGSPHYACPEVIKGEKYDGRRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKR 245
Query: 247 AELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPW 285
H P + PDC +L+R + +P R SLE+I PW
Sbjct: 246 GVFHMPHFIPPDCQSLLRGMIEVEPEKRLSLEQIQKHPW 284
>gi|116256471 SNF1-like kinase [Homo sapiens]
Length = 783
Score = 145 bits (365), Expect = 6e-35
Identities = 99/285 (34%), Positives = 147/285 (51%), Gaps = 26/285 (9%)
Query: 32 YRLGPLLGKGGFGTV-FAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKV 90
Y + LGKG F V A HR+T + QVAIK+I + R+ S+ EV L+ +
Sbjct: 27 YDIERTLGKGNFAVVKLARHRVT-KTQVAIKIIDKTRL----DSSNLEKIYREVQLMKLL 81
Query: 91 GAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAA 150
HP +I+L ET++ +V E + +FDY+T G L E +R F Q+++A
Sbjct: 82 N----HPHIIKLYQVMETKDMLYIVTEFAKNGE-MFDYLTSNGHLSENEARKKFWQILSA 136
Query: 151 IQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHD-EPYTDFDGTRVYSPPEWI 209
+++CH +VHRD+K EN+L+D KL DFG G EP + + G+ Y+ PE
Sbjct: 137 VEYCHDHHIVHRDLKTENLLLDGNMD-IKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVF 195
Query: 210 SRHQYHALPATVWSLGILLYDMVCGDIPFERD------QEILEAELHFPAHVSPDCCALI 263
+Y +WSLG++LY +VCG +PF+ Q +LE P +S DC +LI
Sbjct: 196 EGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLI 255
Query: 264 RRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKGGPAPLAWS 308
RR L P+ R ++ +I WM+ P GPA A+S
Sbjct: 256 RRMLVVDPARRITIAQIRQHRWMRA-------EPCLPGPACPAFS 293
>gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo
sapiens]
Length = 688
Score = 145 bits (365), Expect = 6e-35
Identities = 94/274 (34%), Positives = 144/274 (52%), Gaps = 19/274 (6%)
Query: 32 YRLGPLLGKGGFGTV-FAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKV 90
YRL +GKG F V A H LT R +VAIK+I + + L S L EV ++
Sbjct: 59 YRLLRTIGKGNFAKVKLARHILTGR-EVAIKIIDKTQ-LNPSSLQKLFR---EVRIM--- 110
Query: 91 GAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAA 150
G HP +++L + ET++ LV+E A ++FDY+ G + E +R F Q+V+A
Sbjct: 111 -KGLNHPNIVKLFEVIETEKTLYLVMEYA-SAGEVFDYLVSHGRMKEKEARAKFRQIVSA 168
Query: 151 IQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFG-SGALLHDEPYTDFDGTRVYSPPEWI 209
+ +CH + +VHRD+K EN+L+D K+ DFG S F G+ Y+ PE
Sbjct: 169 VHYCHQKNIVHRDLKAENLLLDAEAN-IKIADFGFSNEFTLGSKLDTFCGSPPYAAPELF 227
Query: 210 SRHQYHALPATVWSLGILLYDMVCGDIPF------ERDQEILEAELHFPAHVSPDCCALI 263
+Y +WSLG++LY +V G +PF E + +L + P ++S DC +++
Sbjct: 228 QGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESIL 287
Query: 264 RRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNP 297
RR L P+ R +LE+I+ D W+ E L P
Sbjct: 288 RRFLVLNPAKRCTLEQIMKDKWINIGYEGEELKP 321
>gi|156105707 SNF related kinase [Homo sapiens]
Length = 765
Score = 142 bits (359), Expect = 3e-34
Identities = 95/267 (35%), Positives = 136/267 (50%), Gaps = 23/267 (8%)
Query: 32 YRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRV--LGWSPLSDSVTCPLEVALLWK 89
Y L LG+G F V + +VA+KVI + ++ L L V C V
Sbjct: 16 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQ---- 71
Query: 90 VGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYIT--EKGPLGEGPSRCFFGQV 147
HP ++RL + +TQ L+LE D+FDYI E+G L E ++ +F Q+
Sbjct: 72 ------HPNIVRLYEVIDTQTKLYLILELG-DGGDMFDYIMKHEEG-LNEDLAKKYFAQI 123
Query: 148 VAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFG-SGALLHDEPYTDFDGTRVYSPP 206
V AI +CH VVHRD+K EN++ ++G KL DFG S + T G+ YS P
Sbjct: 124 VHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAP 183
Query: 207 EWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQE------ILEAELHFPAHVSPDCC 260
E + +Y A +WSLG++L+ +VCG PF+ + I++ + P+HVS +C
Sbjct: 184 EILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECK 243
Query: 261 ALIRRCLAPKPSSRPSLEEILLDPWMQ 287
LI R L P R SLEEI PW+Q
Sbjct: 244 DLITRMLQRDPKRRASLEEIENHPWLQ 270
>gi|156105705 SNF related kinase [Homo sapiens]
Length = 765
Score = 142 bits (359), Expect = 3e-34
Identities = 95/267 (35%), Positives = 136/267 (50%), Gaps = 23/267 (8%)
Query: 32 YRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRV--LGWSPLSDSVTCPLEVALLWK 89
Y L LG+G F V + +VA+KVI + ++ L L V C V
Sbjct: 16 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQ---- 71
Query: 90 VGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYIT--EKGPLGEGPSRCFFGQV 147
HP ++RL + +TQ L+LE D+FDYI E+G L E ++ +F Q+
Sbjct: 72 ------HPNIVRLYEVIDTQTKLYLILELG-DGGDMFDYIMKHEEG-LNEDLAKKYFAQI 123
Query: 148 VAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFG-SGALLHDEPYTDFDGTRVYSPP 206
V AI +CH VVHRD+K EN++ ++G KL DFG S + T G+ YS P
Sbjct: 124 VHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAP 183
Query: 207 EWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQE------ILEAELHFPAHVSPDCC 260
E + +Y A +WSLG++L+ +VCG PF+ + I++ + P+HVS +C
Sbjct: 184 EILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECK 243
Query: 261 ALIRRCLAPKPSSRPSLEEILLDPWMQ 287
LI R L P R SLEEI PW+Q
Sbjct: 244 DLITRMLQRDPKRRASLEEIENHPWLQ 270
>gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo
sapiens]
Length = 795
Score = 142 bits (359), Expect = 3e-34
Identities = 94/282 (33%), Positives = 146/282 (51%), Gaps = 19/282 (6%)
Query: 24 DREAFEAEYRLGPLLGKGGFGTV-FAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPL 82
D + YRL +GKG F V A H LT R +VA+K+I + ++ +P S
Sbjct: 52 DEQPHIGNYRLQKTIGKGNFAKVKLARHVLTGR-EVAVKIIDKTQL---NPTSLQKLFR- 106
Query: 83 EVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRC 142
EV ++ + HP +++L + ET++ LV+E ++FDY+ G + E +R
Sbjct: 107 EVRIMKILN----HPNIVKLFEVIETEKTLYLVMEYA-SGGEVFDYLVAHGRMKEKEARA 161
Query: 143 FFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFG-SGALLHDEPYTDFDGTR 201
F Q+V+A+Q+CH + +VHRD+K EN+L+D K+ DFG S F G+
Sbjct: 162 KFRQIVSAVQYCHQKYIVHRDLKAENLLLDGDMN-IKIADFGFSNEFTVGNKLDTFCGSP 220
Query: 202 VYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPF------ERDQEILEAELHFPAHV 255
Y+ PE +Y VWSLG++LY +V G +PF E + +L + P ++
Sbjct: 221 PYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYM 280
Query: 256 SPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNP 297
S DC L+++ L P R SLE+I+ D WM E+ L P
Sbjct: 281 STDCENLLKKLLVLNPIKRGSLEQIMKDRWMNVGHEEEELKP 322
>gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d
[Homo sapiens]
Length = 713
Score = 140 bits (352), Expect = 2e-33
Identities = 93/282 (32%), Positives = 146/282 (51%), Gaps = 19/282 (6%)
Query: 24 DREAFEAEYRLGPLLGKGGFGTV-FAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPL 82
D + YRL +GKG F V A H LT R +VAIK+I + ++ +P S
Sbjct: 48 DEQPHIGNYRLLKTIGKGNFAKVKLARHILTGR-EVAIKIIDKTQL---NPTSLQKLFR- 102
Query: 83 EVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRC 142
EV ++ + HP +++L + ET++ L++E ++FDY+ G + E +R
Sbjct: 103 EVRIMKILN----HPNIVKLFEVIETEKTLYLIMEYA-SGGEVFDYLVAHGRMKEKEARS 157
Query: 143 FFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFG-SGALLHDEPYTDFDGTR 201
F Q+V+A+Q+CH + +VHRD+K EN+L+D K+ DFG S F G+
Sbjct: 158 KFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMN-IKIADFGFSNEFTVGGKLDTFCGSP 216
Query: 202 VYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPF------ERDQEILEAELHFPAHV 255
Y+ PE +Y VWSLG++LY +V G +PF E + +L + P ++
Sbjct: 217 PYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYM 276
Query: 256 SPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNP 297
S DC L++R L P R +LE+I+ D W+ E+ L P
Sbjct: 277 STDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKP 318
>gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b
[Homo sapiens]
Length = 744
Score = 140 bits (352), Expect = 2e-33
Identities = 93/282 (32%), Positives = 146/282 (51%), Gaps = 19/282 (6%)
Query: 24 DREAFEAEYRLGPLLGKGGFGTV-FAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPL 82
D + YRL +GKG F V A H LT R +VAIK+I + ++ +P S
Sbjct: 48 DEQPHIGNYRLLKTIGKGNFAKVKLARHILTGR-EVAIKIIDKTQL---NPTSLQKLFR- 102
Query: 83 EVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRC 142
EV ++ + HP +++L + ET++ L++E ++FDY+ G + E +R
Sbjct: 103 EVRIMKILN----HPNIVKLFEVIETEKTLYLIMEYA-SGGEVFDYLVAHGRMKEKEARS 157
Query: 143 FFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFG-SGALLHDEPYTDFDGTR 201
F Q+V+A+Q+CH + +VHRD+K EN+L+D K+ DFG S F G+
Sbjct: 158 KFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMN-IKIADFGFSNEFTVGGKLDTFCGSP 216
Query: 202 VYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPF------ERDQEILEAELHFPAHV 255
Y+ PE +Y VWSLG++LY +V G +PF E + +L + P ++
Sbjct: 217 PYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYM 276
Query: 256 SPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNP 297
S DC L++R L P R +LE+I+ D W+ E+ L P
Sbjct: 277 STDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKP 318
>gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a
[Homo sapiens]
Length = 753
Score = 140 bits (352), Expect = 2e-33
Identities = 93/282 (32%), Positives = 146/282 (51%), Gaps = 19/282 (6%)
Query: 24 DREAFEAEYRLGPLLGKGGFGTV-FAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPL 82
D + YRL +GKG F V A H LT R +VAIK+I + ++ +P S
Sbjct: 48 DEQPHIGNYRLLKTIGKGNFAKVKLARHILTGR-EVAIKIIDKTQL---NPTSLQKLFR- 102
Query: 83 EVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRC 142
EV ++ + HP +++L + ET++ L++E ++FDY+ G + E +R
Sbjct: 103 EVRIMKILN----HPNIVKLFEVIETEKTLYLIMEYA-SGGEVFDYLVAHGRMKEKEARS 157
Query: 143 FFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFG-SGALLHDEPYTDFDGTR 201
F Q+V+A+Q+CH + +VHRD+K EN+L+D K+ DFG S F G+
Sbjct: 158 KFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMN-IKIADFGFSNEFTVGGKLDTFCGSP 216
Query: 202 VYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPF------ERDQEILEAELHFPAHV 255
Y+ PE +Y VWSLG++LY +V G +PF E + +L + P ++
Sbjct: 217 PYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYM 276
Query: 256 SPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNP 297
S DC L++R L P R +LE+I+ D W+ E+ L P
Sbjct: 277 STDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKP 318
>gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c
[Homo sapiens]
Length = 729
Score = 140 bits (352), Expect = 2e-33
Identities = 93/282 (32%), Positives = 146/282 (51%), Gaps = 19/282 (6%)
Query: 24 DREAFEAEYRLGPLLGKGGFGTV-FAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPL 82
D + YRL +GKG F V A H LT R +VAIK+I + ++ +P S
Sbjct: 48 DEQPHIGNYRLLKTIGKGNFAKVKLARHILTGR-EVAIKIIDKTQL---NPTSLQKLFR- 102
Query: 83 EVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRC 142
EV ++ + HP +++L + ET++ L++E ++FDY+ G + E +R
Sbjct: 103 EVRIMKILN----HPNIVKLFEVIETEKTLYLIMEYA-SGGEVFDYLVAHGRMKEKEARS 157
Query: 143 FFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFG-SGALLHDEPYTDFDGTR 201
F Q+V+A+Q+CH + +VHRD+K EN+L+D K+ DFG S F G+
Sbjct: 158 KFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMN-IKIADFGFSNEFTVGGKLDTFCGSP 216
Query: 202 VYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPF------ERDQEILEAELHFPAHV 255
Y+ PE +Y VWSLG++LY +V G +PF E + +L + P ++
Sbjct: 217 PYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYM 276
Query: 256 SPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNP 297
S DC L++R L P R +LE+I+ D W+ E+ L P
Sbjct: 277 STDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKP 318
>gi|35038528 PAS domain containing serine/threonine kinase [Homo
sapiens]
Length = 1323
Score = 140 bits (352), Expect = 2e-33
Identities = 95/267 (35%), Positives = 139/267 (52%), Gaps = 12/267 (4%)
Query: 28 FEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLG--W--SPLSDSVTCPLE 83
+ +Y LG G FG V+ +V +K I + +VL W P VT LE
Sbjct: 995 YSQKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVT--LE 1052
Query: 84 VALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCF 143
+A+L +V H +I++LD FE Q F LV+E+ DLF +I L E +
Sbjct: 1053 IAILSRVE----HANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYI 1108
Query: 144 FGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLH-DEPYTDFDGTRV 202
F Q+V+A+ + + ++HRDIKDENI+I KLIDFGS A L + + F GT
Sbjct: 1109 FRQLVSAVGYLRLKDIIHRDIKDENIVI-AEDFTIKLIDFGSAAYLERGKLFYTFCGTIE 1167
Query: 203 YSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCAL 262
Y PE + + Y +WSLG+ LY +V + PF +E +EA +H P VS + +L
Sbjct: 1168 YCAPEVLMGNPYRGPELEMWSLGVTLYTLVFEENPFCELEETVEAAIHPPYLVSKELMSL 1227
Query: 263 IRRCLAPKPSSRPSLEEILLDPWMQTP 289
+ L P P R +LE+++ DPW+ P
Sbjct: 1228 VSGLLQPVPERRTTLEKLVTDPWVTQP 1254
>gi|116089335 BR serine/threonine kinase 2 [Homo sapiens]
Length = 668
Score = 139 bits (351), Expect = 2e-33
Identities = 92/280 (32%), Positives = 144/280 (51%), Gaps = 21/280 (7%)
Query: 15 TPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPL 74
T T GG + YRL LGKG G V G +VAIK++ R + L
Sbjct: 2 TSTGKDGGAQHAQYVGPYRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREK------L 55
Query: 75 SDSVTCPLE--VALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEK 132
S+SV +E +A+L + HP V++L D +E ++ LVLE + +LFDY+ +K
Sbjct: 56 SESVLMKVEREIAILKLIE----HPHVLKLHDVYENKKYLYLVLEH-VSGGELFDYLVKK 110
Query: 133 GPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGAL-LHD 191
G L +R FF Q+++A+ CHS + HRD+K EN+L+D + ++ DFG +L + D
Sbjct: 111 GRLTPKEARKFFRQIISALDFCHSHSICHRDLKPENLLLD-EKNNIRIADFGMASLQVGD 169
Query: 192 EPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERD------QEIL 245
G+ Y+ PE I +Y A VWS G++L+ ++ G +PF+ D +++
Sbjct: 170 SLLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVK 229
Query: 246 EAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPW 285
H P + PDC +L+R + + R +LE I W
Sbjct: 230 RGVFHMPHFIPPDCQSLLRGMIEVDAARRLTLEHIQKHIW 269
>gi|38569460 SNF1-like kinase 2 [Homo sapiens]
Length = 926
Score = 135 bits (341), Expect = 4e-32
Identities = 91/280 (32%), Positives = 138/280 (49%), Gaps = 25/280 (8%)
Query: 32 YRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPL---EVALLW 88
Y + LGKG F V G + +VAIK+I ++++ D+V EV ++
Sbjct: 20 YDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQL-------DAVNLEKIYREVQIMK 72
Query: 89 KVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVV 148
+ HP +I+L ET+ LV E + +FDY+ G L E +R F Q++
Sbjct: 73 MLD----HPHIIKLYQVMETKSMLYLVTEYAKNGE-IFDYLANHGRLNESEARRKFWQIL 127
Query: 149 AAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHD-EPYTDFDGTRVYSPPE 207
+A+ +CH R +VHRD+K EN+L+D K+ DFG G E + G+ Y+ PE
Sbjct: 128 SAVDYCHGRKIVHRDLKAENLLLDNNMN-IKIADFGFGNFFKSGELLATWCGSPPYAAPE 186
Query: 208 WISRHQYHALPATVWSLGILLYDMVCGDIPFERD------QEILEAELHFPAHVSPDCCA 261
QY +WS+G++LY +VCG +PF+ Q +LE P +S DC
Sbjct: 187 VFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEH 246
Query: 262 LIRRCLAPKPSSRPSLEEILLDPWM--QTPAEDVPLNPSK 299
LIRR L PS R ++ +I WM + P + L P +
Sbjct: 247 LIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQE 286
>gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens]
Length = 628
Score = 132 bits (333), Expect = 3e-31
Identities = 90/261 (34%), Positives = 137/261 (52%), Gaps = 16/261 (6%)
Query: 32 YRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVG 91
Y LGKG +G V + RL VAIK I ++++ D + E+ ++ +
Sbjct: 53 YEFLETLGKGTYGKVKKARESSGRL-VAIKSIRKDKI---KDEQDLMHIRREIEIMSSLN 108
Query: 92 AGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAI 151
HP +I + + FE ++V+E DL+DYI+E+ L E +R FF Q+V+A+
Sbjct: 109 ----HPHIIAIHEVFENSSKIVIVMEYASRG-DLYDYISERQQLSEREARHFFRQIVSAV 163
Query: 152 QHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTD-FDGTRVYSPPEWIS 210
+CH VVHRD+K ENIL+D G K+ DFG L H + F G+ +Y+ PE ++
Sbjct: 164 HYCHQNRVVHRDLKLENILLD-ANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPEIVN 222
Query: 211 RHQYHALPATVWSLGILLYDMVCGDIPFE-RDQEILEAELHFPAHVSP----DCCALIRR 265
Y WSLG+LLY +V G +PF+ D +IL ++ A+ P D C LIR
Sbjct: 223 GKPYTGPEVDSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPPKPSDACGLIRW 282
Query: 266 CLAPKPSSRPSLEEILLDPWM 286
L P+ R +LE++ W+
Sbjct: 283 LLMVNPTRRATLEDVASHWWV 303
>gi|23503303 serine/threonine-protein kinase NIM1 [Homo sapiens]
Length = 436
Score = 131 bits (330), Expect = 7e-31
Identities = 93/285 (32%), Positives = 137/285 (48%), Gaps = 23/285 (8%)
Query: 32 YRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPL---EVALLW 88
YR+ +G G F V G + +VAIK++ + ++ D T L E++ +
Sbjct: 74 YRIRGEIGSGNFSQVKLGIHSLTKEKVAIKILDKTKL-------DQKTQRLLSREISSME 126
Query: 89 KVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVV 148
K+ HP +IRL + ET LV+E +LF I+ +G L E S+ F Q+V
Sbjct: 127 KLH----HPNIIRLYEVVETLSKLHLVMEYA-GGGELFGKISTEGKLSEPESKLIFSQIV 181
Query: 149 AAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFG-SGALLHDEPYTDFDGTRVYSPPE 207
+A++H H ++HRD+K EN+ C K+ DFG S E F G+ Y+ PE
Sbjct: 182 SAVKHMHENQIIHRDLKAENVFY-TSNTCVKVGDFGFSTVSKKGEMLNTFCGSPPYAAPE 240
Query: 208 WISRHQYHALPATVWSLGILLYDMVCGDIPFERD------QEILEAELHFPAHVSPDCCA 261
Y + +W+LG+LLY MV G +PF + + ILE P HVS C
Sbjct: 241 LFRDEHYIGIYVDIWALGVLLYFMVTGTMPFRAETVAKLKKSILEGTYSVPPHVSEPCHR 300
Query: 262 LIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKGGPAPLA 306
LIR L P+ R ++ I+ D WMQ PL P + P L+
Sbjct: 301 LIRGVLQQIPTERYGIDCIMNDEWMQGVPYPTPLEPFQLDPKHLS 345
>gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic
subunit isoform 1 [Homo sapiens]
Length = 559
Score = 129 bits (325), Expect = 3e-30
Identities = 83/271 (30%), Positives = 140/271 (51%), Gaps = 21/271 (7%)
Query: 32 YRLGPLLGKGGFGTVFAG-HRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKV 90
Y LG LG G FG V G H LT +VA+K++ R ++ + + ++ L++
Sbjct: 27 YILGDTLGVGTFGKVKVGKHELTGH-KVAVKILNRQKIRSLDVVG-KIRREIQNLKLFR- 83
Query: 91 GAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAA 150
HP +I+L T +V+E + +LFDYI + G L E SR F Q+++
Sbjct: 84 -----HPHIIKLYQVISTPSDIFMVMEY-VSGGELFDYICKNGRLDEKESRRLFQQILSG 137
Query: 151 IQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFD-GTRVYSPPEWI 209
+ +CH VVHRD+K EN+L+D AK+ DFG ++ D + G+ Y+ PE I
Sbjct: 138 VDYCHRHMVVHRDLKPENVLLDAHMN-AKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVI 196
Query: 210 SRHQYHALPATVWSLGILLYDMVCGDIPFERD------QEILEAELHFPAHVSPDCCALI 263
S Y +WS G++LY ++CG +PF+ D ++I + + P +++P +L+
Sbjct: 197 SGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLL 256
Query: 264 RRCLAPKPSSRPSLEEILLDPWMQTPAEDVP 294
+ L P R ++++I W + +D+P
Sbjct: 257 KHMLQVDPMKRATIKDIREHEWFK---QDLP 284
>gi|7657214 hormonally upregulated Neu-associated kinase [Homo
sapiens]
Length = 714
Score = 127 bits (319), Expect = 1e-29
Identities = 82/262 (31%), Positives = 142/262 (54%), Gaps = 22/262 (8%)
Query: 38 LGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHP 97
LG+G F V G + +VAIKVI + R + ++ ++ ++ + + HP
Sbjct: 68 LGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIR------HP 121
Query: 98 GVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSR 157
+ +LLD ET+ + LV+E P +L I EK L E +R + Q+++A++H H
Sbjct: 122 NITQLLDILETENSYYLVMEL-CPGGNLMHKIYEKKRLEESEARRYIRQLISAVEHLHRA 180
Query: 158 GVVHRDIKDENILIDLRRGCAKLIDFG----SGALLHDEPYTDFDGTRVYSPPEWISRHQ 213
GVVHRD+K EN+L+D KLIDFG +G L + +P++ G+ Y+ PE ++R +
Sbjct: 181 GVVHRDLKIENLLLD-EDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLARKK 239
Query: 214 YHALPATVWSLGILLYDMVCGDIPFERD--------QEILEAELH-FPAHVSPDCCALIR 264
Y VWS+G+ +Y M+ G +PF + Q++++ E++ P +S + +R
Sbjct: 240 Y-GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLSTGAISFLR 298
Query: 265 RCLAPKPSSRPSLEEILLDPWM 286
L P P RP++++ L + W+
Sbjct: 299 SLLEPDPVKRPNIQQALANRWL 320
>gi|16418343 testis-specific serine kinase 3 [Homo sapiens]
Length = 268
Score = 127 bits (318), Expect = 2e-29
Identities = 85/266 (31%), Positives = 136/266 (51%), Gaps = 21/266 (7%)
Query: 32 YRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVG 91
Y+LG +G+G + V + +VAIKVI + +G P E+ ++ +
Sbjct: 10 YQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDK---MGGPEEFIQRFLPRELQIVRTLD 66
Query: 92 AGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAI 151
H +I++ + E+ +G + ++ D+FD + GPL E ++ F Q+V AI
Sbjct: 67 ----HKNIIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAI 122
Query: 152 QHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALL---HDEPYTDFDGTRVYSPPEW 208
++CH GV HRD+K EN L L+ KL DFG +L H E F G+ Y+ PE
Sbjct: 123 RYCHGCGVAHRDLKCENAL--LQGFNLKLTDFGFAKVLPKSHRELSQTFCGSTAYAAPEV 180
Query: 209 ISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEI------LEAELHFPAH--VSPDCC 260
+ + + VWS+G++LY M+C +PF+ D +I + + FP H +S DC
Sbjct: 181 LQGIPHDSKKGDVWSMGVVLYVMLCASLPFD-DTDIPKMLWQQQKGVSFPTHLSISADCQ 239
Query: 261 ALIRRCLAPKPSSRPSLEEILLDPWM 286
L++R L P RPS+EE+ PW+
Sbjct: 240 DLLKRLLEPDMILRPSIEEVSWHPWL 265
>gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens]
Length = 651
Score = 126 bits (317), Expect = 2e-29
Identities = 96/278 (34%), Positives = 138/278 (49%), Gaps = 30/278 (10%)
Query: 23 KDREAFEAEYRLGPLLGKGGFGTV-FAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCP 81
KD + Y L +G GGF V A H LT + VAIK++ +N LG SD
Sbjct: 2 KDYDELLKYYELHETIGTGGFAKVKLACHILTGEM-VAIKIMDKN-TLG----SDLPRIK 55
Query: 82 LEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSR 141
E+ L + H + +L ET +VLE P +LFDYI + L E +R
Sbjct: 56 TEIEALKNLR----HQHICQLYHVLETANKIFMVLEY-CPGGELFDYIISQDRLSEEETR 110
Query: 142 CFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFD--- 198
F Q+V+A+ + HS+G HRD+K EN+L D KLIDFG L +P + D
Sbjct: 111 VVFRQIVSAVAYVHSQGYAHRDLKPENLLFD-EYHKLKLIDFG----LCAKPKGNKDYHL 165
Query: 199 ----GTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERD------QEILEAE 248
G+ Y+ PE I Y A VWS+GILLY ++CG +PF+ D ++I+ +
Sbjct: 166 QTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGK 225
Query: 249 LHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWM 286
P +SP L+++ L P R S++ +L PW+
Sbjct: 226 YDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWI 263
>gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]
Length = 661
Score = 124 bits (312), Expect = 8e-29
Identities = 92/285 (32%), Positives = 143/285 (50%), Gaps = 28/285 (9%)
Query: 16 PTPPPGGK---DREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQ---VAIKVIPRNRVL 69
P P G K + + Y L LGKG +G V R T+R VAIK I ++++
Sbjct: 36 PRKPHGVKRHHHKHNLKHRYELQETLGKGTYGKV---KRATERFSGRVVAIKSIRKDKI- 91
Query: 70 GWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYI 129
D V E+ ++ + HP +I + + FE ++ ++++E + L+DYI
Sbjct: 92 --KDEQDMVHIRREIEIMSSLN----HPHIISIYEVFENKDKIVIIMEYASKGE-LYDYI 144
Query: 130 TEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGC-AKLIDFGSGAL 188
+E+ L E +R FF Q+V+A+ +CH GVVHRD+K ENIL+D C K+ DFG L
Sbjct: 145 SERRRLSERETRHFFRQIVSAVHYCHKNGVVHRDLKLENILLD--DNCNIKIADFGLSNL 202
Query: 189 LHDEPYTD-FDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFE------RD 241
+ + F G+ +Y+ PE ++ Y W+LG+LLY +V G +PF+
Sbjct: 203 YQKDKFLQTFCGSPLYASPEIVNGRPYRGPEVDSWALGVLLYTLVYGTMPFDGFDHKNLI 262
Query: 242 QEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWM 286
++I E P S D LIR L P R ++E+I W+
Sbjct: 263 RQISSGEYREPTQPS-DARGLIRWMLMVNPDRRATIEDIANHWWV 306
>gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens]
Length = 1263
Score = 124 bits (310), Expect = 1e-28
Identities = 80/263 (30%), Positives = 127/263 (48%), Gaps = 17/263 (6%)
Query: 32 YRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVG 91
Y + +GKG F V L + +VAIK+I + ++ +++ + K+
Sbjct: 8 YEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLD-----EENLKKIFREVQIMKML 62
Query: 92 AGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAI 151
HP +IRL ET+ LV E ++FD++ G + E +R F Q+V A+
Sbjct: 63 C---HPHIIRLYQVMETERMIYLVTEYA-SGGEIFDHLVAHGRMAEKEARRKFKQIVTAV 118
Query: 152 QHCHSRGVVHRDIKDENILIDLRRGCAKLIDFG-SGALLHDEPYTDFDGTRVYSPPEWIS 210
CH R +VHRD+K EN+L+D K+ DFG S + + G+ Y+ PE
Sbjct: 119 YFCHCRNIVHRDLKAENLLLDANLN-IKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFE 177
Query: 211 RHQYHALPATVWSLGILLYDMVCGDIPFERD------QEILEAELHFPAHVSPDCCALIR 264
+Y +WSLG++LY +VCG +PF+ +L + P +S +C LIR
Sbjct: 178 GKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIR 237
Query: 265 RCLAPKPSSRPSLEEILLDPWMQ 287
L P+ R S+E+I WM+
Sbjct: 238 HMLVLDPNKRLSMEQICKHKWMK 260
>gi|46877068 AMP-activated protein kinase alpha 2 catalytic subunit
[Homo sapiens]
Length = 552
Score = 123 bits (308), Expect = 2e-28
Identities = 83/277 (29%), Positives = 141/277 (50%), Gaps = 20/277 (7%)
Query: 32 YRLGPLLGKGGFGTVFAG-HRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKV 90
Y LG LG G FG V G H+LT +VA+K++ R ++ + + ++ L++
Sbjct: 16 YVLGDTLGVGTFGKVKIGEHQLTGH-KVAVKILNRQKIRSLDVVG-KIKREIQNLKLFR- 72
Query: 91 GAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAA 150
HP +I+L T F +V+E + +LFDYI + G + E +R F Q+++A
Sbjct: 73 -----HPHIIKLYQVISTPTDFFMVMEY-VSGGELFDYICKHGRVEEMEARRLFQQILSA 126
Query: 151 IQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFD-GTRVYSPPEWI 209
+ +CH VVHRD+K EN+L+D AK+ DFG ++ D + G+ Y+ PE I
Sbjct: 127 VDYCHRHMVVHRDLKPENVLLDAHMN-AKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVI 185
Query: 210 SRHQYHALPATVWSLGILLYDMVCGDIPFERD------QEILEAELHFPAHVSPDCCALI 263
S Y +WS G++LY ++CG +PF+ + ++I + P +++ L+
Sbjct: 186 SGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLL 245
Query: 264 RRCLAPKPSSRPSLEEILLDPWMQ--TPAEDVPLNPS 298
L P R ++++I W + P+ P +PS
Sbjct: 246 MHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPS 282
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.143 0.469
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,629,898
Number of Sequences: 37866
Number of extensions: 934296
Number of successful extensions: 9977
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 554
Number of HSP's successfully gapped in prelim test: 306
Number of HSP's that attempted gapping in prelim test: 7221
Number of HSP's gapped (non-prelim): 1852
length of query: 311
length of database: 18,247,518
effective HSP length: 102
effective length of query: 209
effective length of database: 14,385,186
effective search space: 3006503874
effective search space used: 3006503874
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.