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Search of human proteins with 42734401
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|42734401 testis-specific serine kinase 4 [Homo sapiens]
(328 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|42734401 testis-specific serine kinase 4 [Homo sapiens] 668 0.0
gi|14042947 testis-specific serine kinase 1 [Homo sapiens] 224 1e-58
gi|194294513 testis-specific serine kinase 2 [Homo sapiens] 224 1e-58
gi|16418343 testis-specific serine kinase 3 [Homo sapiens] 215 5e-56
gi|14042966 testis-specific serine kinase 6 [Homo sapiens] 200 2e-51
gi|254028240 MAP/microtubule affinity-regulating kinase 2 isofor... 174 1e-43
gi|254028237 MAP/microtubule affinity-regulating kinase 2 isofor... 174 1e-43
gi|254028234 MAP/microtubule affinity-regulating kinase 2 isofor... 174 1e-43
gi|254028232 MAP/microtubule affinity-regulating kinase 2 isofor... 174 1e-43
gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform... 174 1e-43
gi|116089335 BR serine/threonine kinase 2 [Homo sapiens] 173 2e-43
gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens] 172 3e-43
gi|38569460 SNF1-like kinase 2 [Homo sapiens] 171 8e-43
gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor... 171 1e-42
gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor... 171 1e-42
gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor... 171 1e-42
gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform... 171 1e-42
gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo ... 170 2e-42
gi|116256471 SNF1-like kinase [Homo sapiens] 169 2e-42
gi|24308326 BR serine/threonine kinase 1 [Homo sapiens] 169 4e-42
gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s... 164 8e-41
gi|7662170 AMPK-related protein kinase 5 [Homo sapiens] 161 8e-40
gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens] 155 5e-38
gi|156105707 SNF related kinase [Homo sapiens] 152 4e-37
gi|156105705 SNF related kinase [Homo sapiens] 152 4e-37
gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens] 152 4e-37
gi|46877068 AMP-activated protein kinase alpha 2 catalytic subun... 152 5e-37
gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic sub... 149 3e-36
gi|23503303 serine/threonine-protein kinase NIM1 [Homo sapiens] 142 4e-34
gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic sub... 140 2e-33
>gi|42734401 testis-specific serine kinase 4 [Homo sapiens]
Length = 328
Score = 668 bits (1723), Expect = 0.0
Identities = 328/328 (100%), Positives = 328/328 (100%)
Query: 1 MGKGDVLEAAPTTTAYHSLMDEYGYEVGKAIGHGSYGSVYEAFYTKQKVMVAVKIISKKK 60
MGKGDVLEAAPTTTAYHSLMDEYGYEVGKAIGHGSYGSVYEAFYTKQKVMVAVKIISKKK
Sbjct: 1 MGKGDVLEAAPTTTAYHSLMDEYGYEVGKAIGHGSYGSVYEAFYTKQKVMVAVKIISKKK 60
Query: 61 ASDDYLNKFLPREIQVMKVLRHKYLINFYRAIESTSRVYIILELAQGGDVLEWIQRYGAC 120
ASDDYLNKFLPREIQVMKVLRHKYLINFYRAIESTSRVYIILELAQGGDVLEWIQRYGAC
Sbjct: 61 ASDDYLNKFLPREIQVMKVLRHKYLINFYRAIESTSRVYIILELAQGGDVLEWIQRYGAC 120
Query: 121 SEPLAGKWFSQLTLGIAYLHSKSIVHRDLKLENLLLDKWENVKISDFGFAKMVPSNQPVG 180
SEPLAGKWFSQLTLGIAYLHSKSIVHRDLKLENLLLDKWENVKISDFGFAKMVPSNQPVG
Sbjct: 121 SEPLAGKWFSQLTLGIAYLHSKSIVHRDLKLENLLLDKWENVKISDFGFAKMVPSNQPVG 180
Query: 181 CSPSYRQVNCFSHLSQTYCGSFAYACPEILRGLPYNPFLSDTWSMGVILYTLVVAHLPFD 240
CSPSYRQVNCFSHLSQTYCGSFAYACPEILRGLPYNPFLSDTWSMGVILYTLVVAHLPFD
Sbjct: 181 CSPSYRQVNCFSHLSQTYCGSFAYACPEILRGLPYNPFLSDTWSMGVILYTLVVAHLPFD 240
Query: 241 DTNLKKLLRETQKEVTFPANHTISQECKNLILQMLRQATKRATILDIIKDSWVLKFQPEQ 300
DTNLKKLLRETQKEVTFPANHTISQECKNLILQMLRQATKRATILDIIKDSWVLKFQPEQ
Sbjct: 241 DTNLKKLLRETQKEVTFPANHTISQECKNLILQMLRQATKRATILDIIKDSWVLKFQPEQ 300
Query: 301 PTHEIRLLEAMCQLHNTTKQHQSLQITT 328
PTHEIRLLEAMCQLHNTTKQHQSLQITT
Sbjct: 301 PTHEIRLLEAMCQLHNTTKQHQSLQITT 328
>gi|14042947 testis-specific serine kinase 1 [Homo sapiens]
Length = 367
Score = 224 bits (570), Expect = 1e-58
Identities = 122/279 (43%), Positives = 175/279 (62%), Gaps = 14/279 (5%)
Query: 18 SLMDEYGYEVGKAIGHGSYGSVYEAFYTKQKVMVAVKIISKKKASDDYLNKFLPREIQVM 77
+++ GY +G +G GSY V A+ + K VA+KII +KKA D+L KFLPREI+++
Sbjct: 5 AVLKRRGYLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPREIEIL 64
Query: 78 KVLRHKYLINFYRAIEST-SRVYIILELAQGGDVLEWIQRYGACSEPLAGKWFSQLTLGI 136
+L H +I Y E++ +VYI++ELA GD+LE I+ GA E A K F QL+L I
Sbjct: 65 AMLNHCSIIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQLSLAI 124
Query: 137 AYLHSKSIVHRDLKLENLLLDKWENVKISDFGFAKMVPSNQPVGCSPSYRQVNCFSHLSQ 196
Y H +VHRDLK +NLLLDK N+K+SDF F+K R + LS+
Sbjct: 125 KYCHDLDVVHRDLKCDNLLLDKDFNIKLSDFSFSKR-----------CLRDDSGRMALSK 173
Query: 197 TYCGSFAYACPEILRGLPYNPFLSDTWSMGVILYTLVVAHLPFDDTNLKKLLR-ETQKEV 255
T+CGS AYA PE+L+G+PY P + D WS+GVILY +V +P+DD+N+KK+LR + + V
Sbjct: 174 TFCGSPAYAAPEVLQGIPYQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLRIQKEHRV 233
Query: 256 TFPANHTISQECKNLILQMLR-QATKRATILDIIKDSWV 293
FP + ++ ECK+LI ML+ +R I +I+ W+
Sbjct: 234 NFPRSKHLTGECKDLIYHMLQPDVNRRLHIDEILSHCWM 272
>gi|194294513 testis-specific serine kinase 2 [Homo sapiens]
Length = 358
Score = 224 bits (570), Expect = 1e-58
Identities = 123/287 (42%), Positives = 179/287 (62%), Gaps = 17/287 (5%)
Query: 18 SLMDEYGYEVGKAIGHGSYGSVYEAFYTKQKVMVAVKIISKKKASDDYLNKFLPREIQVM 77
+++ + GY VG +G GSY V A+ + K VAVKII +KK D++ +FLPRE+ ++
Sbjct: 5 TVLRKKGYIVGINLGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPREMDIL 64
Query: 78 KVLRHKYLINFYRAIE-STSRVYIILELAQGGDVLEWIQRYGACSEPLAGKWFSQLTLGI 136
+ H +I Y E S R+YII+EL GD+LE+I+ GA E +A K F QL+ +
Sbjct: 65 ATVNHGSIIKTYEIFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQLSSAV 124
Query: 137 AYLHSKSIVHRDLKLENLLLDKWENVKISDFGFAKMVPSNQPVGCSPSYRQVNCFSHLSQ 196
Y H IVHRDLK ENLLLDK N+K+SDFGF+K R N LS+
Sbjct: 125 KYCHDLDIVHRDLKCENLLLDKDFNIKLSDFGFSKR-----------CLRDSNGRIILSK 173
Query: 197 TYCGSFAYACPEILRGLPYNPFLSDTWSMGVILYTLVVAHLPFDDTNLKKLLR-ETQKEV 255
T+CGS AYA PE+L+ +PY P + D WS+GVILY +V +P+DD++++K+LR + + V
Sbjct: 174 TFCGSAAYAAPEVLQSIPYQPKVYDIWSLGVILYIMVCGSMPYDDSDIRKMLRIQKEHRV 233
Query: 256 TFPANHTISQECKNLILQMLR-QATKRATILDIIKDSWVLKFQPEQP 301
FP + ++ ECK+LI +ML+ ++R I +I+ SW+ QP +P
Sbjct: 234 DFPRSKNLTCECKDLIYRMLQPDVSQRLHIDEILSHSWL---QPPKP 277
>gi|16418343 testis-specific serine kinase 3 [Homo sapiens]
Length = 268
Score = 215 bits (547), Expect = 5e-56
Identities = 108/253 (42%), Positives = 165/253 (65%), Gaps = 16/253 (6%)
Query: 24 GYEVGKAIGHGSYGSVYEAFYTKQKVMVAVKIISKKKASDDYLNKFLPREIQVMKVLRHK 83
GY++GK IG G+Y V EAF K + VA+K+I K ++++ +FLPRE+Q+++ L HK
Sbjct: 9 GYQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRFLPRELQIVRTLDHK 68
Query: 84 YLINFYRAIESTS-RVYIILELAQGGDVLEWIQRYGACSEPLAGKWFSQLTLGIAYLHSK 142
+I Y +ES ++ +++ELA+GGDV + + G E A F Q+ I Y H
Sbjct: 69 NIIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRYCHGC 128
Query: 143 SIVHRDLKLENLLLDKWENVKISDFGFAKMVPSNQPVGCSPSYRQVNCFSHLSQTYCGSF 202
+ HRDLK EN LL + N+K++DFGFAK++P S+R+ LSQT+CGS
Sbjct: 129 GVAHRDLKCENALLQGF-NLKLTDFGFAKVLPK--------SHRE------LSQTFCGST 173
Query: 203 AYACPEILRGLPYNPFLSDTWSMGVILYTLVVAHLPFDDTNLKKLLRETQKEVTFPANHT 262
AYA PE+L+G+P++ D WSMGV+LY ++ A LPFDDT++ K+L + QK V+FP + +
Sbjct: 174 AYAAPEVLQGIPHDSKKGDVWSMGVVLYVMLCASLPFDDTDIPKMLWQQQKGVSFPTHLS 233
Query: 263 ISQECKNLILQML 275
IS +C++L+ ++L
Sbjct: 234 ISADCQDLLKRLL 246
>gi|14042966 testis-specific serine kinase 6 [Homo sapiens]
Length = 273
Score = 200 bits (508), Expect = 2e-51
Identities = 106/278 (38%), Positives = 167/278 (60%), Gaps = 19/278 (6%)
Query: 19 LMDEYGYEVGKAIGHGSYGSVYEAFYTKQKVMVAVKIISKKKASDDYLNKFLPREIQVMK 78
L+ E GY++G+ IG GSY V A K K VA+K++ +++A D++NKFLPRE+ +++
Sbjct: 6 LLSELGYKLGRTIGEGSYSKVKVATSKKYKGTVAIKVVDRRRAPPDFVNKFLPRELSILR 65
Query: 79 VLRHKYLINFYRAIE-STSRVYIILELAQGGDVLEWIQRYGACSEPLAGKWFSQLTLGIA 137
+RH ++++ + IE ++YI++E A D+L+ +QR G A F+Q+ +
Sbjct: 66 GVRHPHIVHVFEFIEVCNGKLYIVME-AAATDLLQAVQRNGRIPGVQARDLFAQIAGAVR 124
Query: 138 YLHSKSIVHRDLKLENLLLDKWE-NVKISDFGFAKMVPSNQPVGCSPSYRQVNCFSHLSQ 196
YLH +VHRDLK EN+LL E VK++DFGF RQ + + LS
Sbjct: 125 YLHDHHLVHRDLKCENVLLSPDERRVKLTDFGFG---------------RQAHGYPDLST 169
Query: 197 TYCGSFAYACPEILRGLPYNPFLSDTWSMGVILYTLVVAHLPFDDTNLKKLLRETQKEVT 256
TYCGS AYA PE+L G+PY+P D WSMGV+LY +V +PFDD+++ L R ++ V
Sbjct: 170 TYCGSAAYASPEVLLGIPYDPKKYDVWSMGVVLYVMVTGCMPFDDSDIAGLPRRQKRGVL 229
Query: 257 FPANHTISQECKNLILQMLR-QATKRATILDIIKDSWV 293
+P +S+ CK LI ++L+ + R + + ++ W+
Sbjct: 230 YPEGLELSERCKALIAELLQFSPSARPSAGQVARNCWL 267
>gi|254028240 MAP/microtubule affinity-regulating kinase 2 isoform f
[Homo sapiens]
Length = 709
Score = 174 bits (441), Expect = 1e-43
Identities = 104/270 (38%), Positives = 150/270 (55%), Gaps = 19/270 (7%)
Query: 25 YEVGKAIGHGSYGSVYEAFYTKQKVMVAVKIISKKKASDDYLNKFLPREIQVMKVLRHKY 84
Y + K IG G++ V A + VAVKII K + + L K RE+++MKVL H
Sbjct: 53 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLF-REVRIMKVLNHPN 111
Query: 85 LINFYRAIESTSRVYIILELAQGGDVLEWIQRYGACSEPLAGKWFSQLTLGIAYLHSKSI 144
++ + IE+ +Y+++E A GG+V +++ +G E A F Q+ + Y H K I
Sbjct: 112 IVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFI 171
Query: 145 VHRDLKLENLLLDKWENVKISDFGFAKMVPSNQPVGCSPSYRQVNCFSHLSQTYCGSFAY 204
VHRDLK ENLLLD N+KI+DFGF SN+ F + T+CGS Y
Sbjct: 172 VHRDLKAENLLLDADMNIKIADFGF-----SNE-----------FTFGNKLDTFCGSPPY 215
Query: 205 ACPEILRGLPYNPFLSDTWSMGVILYTLVVAHLPFDDTNLKKLLRETQKEVTFPANHTIS 264
A PE+ +G Y+ D WS+GVILYTLV LPFD NLK+ LRE + +S
Sbjct: 216 AAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKE-LRERVLRGKYRIPFYMS 274
Query: 265 QECKNLILQ-MLRQATKRATILDIIKDSWV 293
+C+NL+ + ++ +KR T+ I+KD W+
Sbjct: 275 TDCENLLKKFLILNPSKRGTLEQIMKDRWM 304
>gi|254028237 MAP/microtubule affinity-regulating kinase 2 isoform e
[Homo sapiens]
Length = 719
Score = 174 bits (441), Expect = 1e-43
Identities = 104/270 (38%), Positives = 150/270 (55%), Gaps = 19/270 (7%)
Query: 25 YEVGKAIGHGSYGSVYEAFYTKQKVMVAVKIISKKKASDDYLNKFLPREIQVMKVLRHKY 84
Y + K IG G++ V A + VAVKII K + + L K RE+++MKVL H
Sbjct: 53 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLF-REVRIMKVLNHPN 111
Query: 85 LINFYRAIESTSRVYIILELAQGGDVLEWIQRYGACSEPLAGKWFSQLTLGIAYLHSKSI 144
++ + IE+ +Y+++E A GG+V +++ +G E A F Q+ + Y H K I
Sbjct: 112 IVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFI 171
Query: 145 VHRDLKLENLLLDKWENVKISDFGFAKMVPSNQPVGCSPSYRQVNCFSHLSQTYCGSFAY 204
VHRDLK ENLLLD N+KI+DFGF SN+ F + T+CGS Y
Sbjct: 172 VHRDLKAENLLLDADMNIKIADFGF-----SNE-----------FTFGNKLDTFCGSPPY 215
Query: 205 ACPEILRGLPYNPFLSDTWSMGVILYTLVVAHLPFDDTNLKKLLRETQKEVTFPANHTIS 264
A PE+ +G Y+ D WS+GVILYTLV LPFD NLK+ LRE + +S
Sbjct: 216 AAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKE-LRERVLRGKYRIPFYMS 274
Query: 265 QECKNLILQ-MLRQATKRATILDIIKDSWV 293
+C+NL+ + ++ +KR T+ I+KD W+
Sbjct: 275 TDCENLLKKFLILNPSKRGTLEQIMKDRWM 304
>gi|254028234 MAP/microtubule affinity-regulating kinase 2 isoform d
[Homo sapiens]
Length = 788
Score = 174 bits (441), Expect = 1e-43
Identities = 104/270 (38%), Positives = 150/270 (55%), Gaps = 19/270 (7%)
Query: 25 YEVGKAIGHGSYGSVYEAFYTKQKVMVAVKIISKKKASDDYLNKFLPREIQVMKVLRHKY 84
Y + K IG G++ V A + VAVKII K + + L K RE+++MKVL H
Sbjct: 53 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLF-REVRIMKVLNHPN 111
Query: 85 LINFYRAIESTSRVYIILELAQGGDVLEWIQRYGACSEPLAGKWFSQLTLGIAYLHSKSI 144
++ + IE+ +Y+++E A GG+V +++ +G E A F Q+ + Y H K I
Sbjct: 112 IVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFI 171
Query: 145 VHRDLKLENLLLDKWENVKISDFGFAKMVPSNQPVGCSPSYRQVNCFSHLSQTYCGSFAY 204
VHRDLK ENLLLD N+KI+DFGF SN+ F + T+CGS Y
Sbjct: 172 VHRDLKAENLLLDADMNIKIADFGF-----SNE-----------FTFGNKLDTFCGSPPY 215
Query: 205 ACPEILRGLPYNPFLSDTWSMGVILYTLVVAHLPFDDTNLKKLLRETQKEVTFPANHTIS 264
A PE+ +G Y+ D WS+GVILYTLV LPFD NLK+ LRE + +S
Sbjct: 216 AAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKE-LRERVLRGKYRIPFYMS 274
Query: 265 QECKNLILQ-MLRQATKRATILDIIKDSWV 293
+C+NL+ + ++ +KR T+ I+KD W+
Sbjct: 275 TDCENLLKKFLILNPSKRGTLEQIMKDRWM 304
>gi|254028232 MAP/microtubule affinity-regulating kinase 2 isoform c
[Homo sapiens]
Length = 724
Score = 174 bits (441), Expect = 1e-43
Identities = 104/270 (38%), Positives = 150/270 (55%), Gaps = 19/270 (7%)
Query: 25 YEVGKAIGHGSYGSVYEAFYTKQKVMVAVKIISKKKASDDYLNKFLPREIQVMKVLRHKY 84
Y + K IG G++ V A + VAVKII K + + L K RE+++MKVL H
Sbjct: 53 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLF-REVRIMKVLNHPN 111
Query: 85 LINFYRAIESTSRVYIILELAQGGDVLEWIQRYGACSEPLAGKWFSQLTLGIAYLHSKSI 144
++ + IE+ +Y+++E A GG+V +++ +G E A F Q+ + Y H K I
Sbjct: 112 IVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFI 171
Query: 145 VHRDLKLENLLLDKWENVKISDFGFAKMVPSNQPVGCSPSYRQVNCFSHLSQTYCGSFAY 204
VHRDLK ENLLLD N+KI+DFGF SN+ F + T+CGS Y
Sbjct: 172 VHRDLKAENLLLDADMNIKIADFGF-----SNE-----------FTFGNKLDTFCGSPPY 215
Query: 205 ACPEILRGLPYNPFLSDTWSMGVILYTLVVAHLPFDDTNLKKLLRETQKEVTFPANHTIS 264
A PE+ +G Y+ D WS+GVILYTLV LPFD NLK+ LRE + +S
Sbjct: 216 AAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKE-LRERVLRGKYRIPFYMS 274
Query: 265 QECKNLILQ-MLRQATKRATILDIIKDSWV 293
+C+NL+ + ++ +KR T+ I+KD W+
Sbjct: 275 TDCENLLKKFLILNPSKRGTLEQIMKDRWM 304
>gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform a
[Homo sapiens]
Length = 745
Score = 174 bits (441), Expect = 1e-43
Identities = 104/270 (38%), Positives = 150/270 (55%), Gaps = 19/270 (7%)
Query: 25 YEVGKAIGHGSYGSVYEAFYTKQKVMVAVKIISKKKASDDYLNKFLPREIQVMKVLRHKY 84
Y + K IG G++ V A + VAVKII K + + L K RE+++MKVL H
Sbjct: 20 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLF-REVRIMKVLNHPN 78
Query: 85 LINFYRAIESTSRVYIILELAQGGDVLEWIQRYGACSEPLAGKWFSQLTLGIAYLHSKSI 144
++ + IE+ +Y+++E A GG+V +++ +G E A F Q+ + Y H K I
Sbjct: 79 IVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFI 138
Query: 145 VHRDLKLENLLLDKWENVKISDFGFAKMVPSNQPVGCSPSYRQVNCFSHLSQTYCGSFAY 204
VHRDLK ENLLLD N+KI+DFGF SN+ F + T+CGS Y
Sbjct: 139 VHRDLKAENLLLDADMNIKIADFGF-----SNE-----------FTFGNKLDTFCGSPPY 182
Query: 205 ACPEILRGLPYNPFLSDTWSMGVILYTLVVAHLPFDDTNLKKLLRETQKEVTFPANHTIS 264
A PE+ +G Y+ D WS+GVILYTLV LPFD NLK+ LRE + +S
Sbjct: 183 AAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKE-LRERVLRGKYRIPFYMS 241
Query: 265 QECKNLILQ-MLRQATKRATILDIIKDSWV 293
+C+NL+ + ++ +KR T+ I+KD W+
Sbjct: 242 TDCENLLKKFLILNPSKRGTLEQIMKDRWM 271
>gi|116089335 BR serine/threonine kinase 2 [Homo sapiens]
Length = 668
Score = 173 bits (438), Expect = 2e-43
Identities = 102/282 (36%), Positives = 162/282 (57%), Gaps = 23/282 (8%)
Query: 25 YEVGKAIGHGSYGSVYEAFYTKQKVMVAVKIISKKKASDDYLNKFLPREIQVMKVLRHKY 84
Y + K +G G G V + VA+KI++++K S+ L K + REI ++K++ H +
Sbjct: 19 YRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVLMK-VEREIAILKLIEHPH 77
Query: 85 LINFYRAIESTSRVYIILELAQGGDVLEWIQRYGACSEPLAGKWFSQLTLGIAYLHSKSI 144
++ + E+ +Y++LE GG++ +++ + G + A K+F Q+ + + HS SI
Sbjct: 78 VLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSI 137
Query: 145 VHRDLKLENLLLDKWENVKISDFGFAKMVPSNQPVGCSPSYRQVNCFSHLSQTYCGSFAY 204
HRDLK ENLLLD+ N++I+DFG A + VG S L +T CGS Y
Sbjct: 138 CHRDLKPENLLLDEKNNIRIADFGMASL-----QVGDS-----------LLETSCGSPHY 181
Query: 205 ACPEILRGLPYNPFLSDTWSMGVILYTLVVAHLPFDDTNLKKLLRETQKEVTFPANHTIS 264
ACPE++RG Y+ +D WS GVIL+ L+V LPFDD NL++LL + ++ V F H I
Sbjct: 182 ACPEVIRGEKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGV-FHMPHFIP 240
Query: 265 QECKNLILQMLR-QATKRATILDIIKDSWVL----KFQPEQP 301
+C++L+ M+ A +R T+ I K W + + +PEQP
Sbjct: 241 PDCQSLLRGMIEVDAARRLTLEHIQKHIWYIGGKNEPEPEQP 282
>gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens]
Length = 1263
Score = 172 bits (437), Expect = 3e-43
Identities = 105/290 (36%), Positives = 157/290 (54%), Gaps = 22/290 (7%)
Query: 25 YEVGKAIGHGSYGSVYEAFYTKQKVMVAVKIISKKKASDDYLNKFLPREIQVMKVLRHKY 84
YE+ + IG G++ V A + K VA+KII K + ++ L K RE+Q+MK+L H +
Sbjct: 8 YEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIF-REVQIMKMLCHPH 66
Query: 85 LINFYRAIESTSRVYIILELAQGGDVLEWIQRYGACSEPLAGKWFSQLTLGIAYLHSKSI 144
+I Y+ +E+ +Y++ E A GG++ + + +G +E A + F Q+ + + H ++I
Sbjct: 67 IIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNI 126
Query: 145 VHRDLKLENLLLDKWENVKISDFGFAKMVPSNQPVGCSPSYRQVNCFSHLSQTYCGSFAY 204
VHRDLK ENLLLD N+KI+DFGF+ + Q L +T+CGS Y
Sbjct: 127 VHRDLKAENLLLDANLNIKIADFGFSNLFTPGQ----------------LLKTWCGSPPY 170
Query: 205 ACPEILRGLPYNPFLSDTWSMGVILYTLVVAHLPFDDTNLKKLLRETQKEVTFPANHTIS 264
A PE+ G Y+ D WS+GV+LY LV LPFD + L+ LR F +S
Sbjct: 171 AAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQN-LRARVLSGKFRIPFFMS 229
Query: 265 QECKNLILQML-RQATKRATILDIIKDSWVLKFQPEQPTHEIRLLEAMCQ 313
EC++LI ML KR ++ I K W +K P + RL+ A CQ
Sbjct: 230 TECEHLIRHMLVLDPNKRLSMEQICKHKW-MKLGDADPNFD-RLI-AECQ 276
>gi|38569460 SNF1-like kinase 2 [Homo sapiens]
Length = 926
Score = 171 bits (433), Expect = 8e-43
Identities = 101/277 (36%), Positives = 150/277 (54%), Gaps = 19/277 (6%)
Query: 25 YEVGKAIGHGSYGSVYEAFYTKQKVMVAVKIISKKKASDDYLNKFLPREIQVMKVLRHKY 84
Y++ +G G++ V + K VA+KII K + L K RE+Q+MK+L H +
Sbjct: 20 YDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIY-REVQIMKMLDHPH 78
Query: 85 LINFYRAIESTSRVYIILELAQGGDVLEWIQRYGACSEPLAGKWFSQLTLGIAYLHSKSI 144
+I Y+ +E+ S +Y++ E A+ G++ +++ +G +E A + F Q+ + Y H + I
Sbjct: 79 IIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKI 138
Query: 145 VHRDLKLENLLLDKWENVKISDFGFAKMVPSNQPVGCSPSYRQVNCFSHLSQTYCGSFAY 204
VHRDLK ENLLLD N+KI+DFGF S + L T+CGS Y
Sbjct: 139 VHRDLKAENLLLDNNMNIKIADFGFGNFFKSGE----------------LLATWCGSPPY 182
Query: 205 ACPEILRGLPYNPFLSDTWSMGVILYTLVVAHLPFDDTNLKKLLRETQKEVTFPANHTIS 264
A PE+ G Y D WSMGV+LY LV LPFD L +LR+ E F + +S
Sbjct: 183 AAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTL-PILRQRVLEGRFRIPYFMS 241
Query: 265 QECKNLILQML-RQATKRATILDIIKDSWVLKFQPEQ 300
++C++LI +ML +KR TI I + W+L P Q
Sbjct: 242 EDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQ 278
>gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d
[Homo sapiens]
Length = 713
Score = 171 bits (432), Expect = 1e-42
Identities = 101/270 (37%), Positives = 145/270 (53%), Gaps = 19/270 (7%)
Query: 25 YEVGKAIGHGSYGSVYEAFYTKQKVMVAVKIISKKKASDDYLNKFLPREIQVMKVLRHKY 84
Y + K IG G++ V A + VA+KII K + + L K RE+++MK+L H
Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLF-REVRIMKILNHPN 114
Query: 85 LINFYRAIESTSRVYIILELAQGGDVLEWIQRYGACSEPLAGKWFSQLTLGIAYLHSKSI 144
++ + IE+ +Y+I+E A GG+V +++ +G E A F Q+ + Y H K I
Sbjct: 115 IVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRI 174
Query: 145 VHRDLKLENLLLDKWENVKISDFGFAKMVPSNQPVGCSPSYRQVNCFSHLSQTYCGSFAY 204
VHRDLK ENLLLD N+KI+DFGF+ + T+CGS Y
Sbjct: 175 VHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKL----------------DTFCGSPPY 218
Query: 205 ACPEILRGLPYNPFLSDTWSMGVILYTLVVAHLPFDDTNLKKLLRETQKEVTFPANHTIS 264
A PE+ +G Y+ D WS+GVILYTLV LPFD NLK+ LRE + +S
Sbjct: 219 AAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKE-LRERVLRGKYRIPFYMS 277
Query: 265 QECKNLILQML-RQATKRATILDIIKDSWV 293
+C+NL+ + L KR T+ I+KD W+
Sbjct: 278 TDCENLLKRFLVLNPIKRGTLEQIMKDRWI 307
>gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b
[Homo sapiens]
Length = 744
Score = 171 bits (432), Expect = 1e-42
Identities = 101/270 (37%), Positives = 145/270 (53%), Gaps = 19/270 (7%)
Query: 25 YEVGKAIGHGSYGSVYEAFYTKQKVMVAVKIISKKKASDDYLNKFLPREIQVMKVLRHKY 84
Y + K IG G++ V A + VA+KII K + + L K RE+++MK+L H
Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLF-REVRIMKILNHPN 114
Query: 85 LINFYRAIESTSRVYIILELAQGGDVLEWIQRYGACSEPLAGKWFSQLTLGIAYLHSKSI 144
++ + IE+ +Y+I+E A GG+V +++ +G E A F Q+ + Y H K I
Sbjct: 115 IVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRI 174
Query: 145 VHRDLKLENLLLDKWENVKISDFGFAKMVPSNQPVGCSPSYRQVNCFSHLSQTYCGSFAY 204
VHRDLK ENLLLD N+KI+DFGF+ + T+CGS Y
Sbjct: 175 VHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKL----------------DTFCGSPPY 218
Query: 205 ACPEILRGLPYNPFLSDTWSMGVILYTLVVAHLPFDDTNLKKLLRETQKEVTFPANHTIS 264
A PE+ +G Y+ D WS+GVILYTLV LPFD NLK+ LRE + +S
Sbjct: 219 AAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKE-LRERVLRGKYRIPFYMS 277
Query: 265 QECKNLILQML-RQATKRATILDIIKDSWV 293
+C+NL+ + L KR T+ I+KD W+
Sbjct: 278 TDCENLLKRFLVLNPIKRGTLEQIMKDRWI 307
>gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a
[Homo sapiens]
Length = 753
Score = 171 bits (432), Expect = 1e-42
Identities = 101/270 (37%), Positives = 145/270 (53%), Gaps = 19/270 (7%)
Query: 25 YEVGKAIGHGSYGSVYEAFYTKQKVMVAVKIISKKKASDDYLNKFLPREIQVMKVLRHKY 84
Y + K IG G++ V A + VA+KII K + + L K RE+++MK+L H
Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLF-REVRIMKILNHPN 114
Query: 85 LINFYRAIESTSRVYIILELAQGGDVLEWIQRYGACSEPLAGKWFSQLTLGIAYLHSKSI 144
++ + IE+ +Y+I+E A GG+V +++ +G E A F Q+ + Y H K I
Sbjct: 115 IVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRI 174
Query: 145 VHRDLKLENLLLDKWENVKISDFGFAKMVPSNQPVGCSPSYRQVNCFSHLSQTYCGSFAY 204
VHRDLK ENLLLD N+KI+DFGF+ + T+CGS Y
Sbjct: 175 VHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKL----------------DTFCGSPPY 218
Query: 205 ACPEILRGLPYNPFLSDTWSMGVILYTLVVAHLPFDDTNLKKLLRETQKEVTFPANHTIS 264
A PE+ +G Y+ D WS+GVILYTLV LPFD NLK+ LRE + +S
Sbjct: 219 AAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKE-LRERVLRGKYRIPFYMS 277
Query: 265 QECKNLILQML-RQATKRATILDIIKDSWV 293
+C+NL+ + L KR T+ I+KD W+
Sbjct: 278 TDCENLLKRFLVLNPIKRGTLEQIMKDRWI 307
>gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c
[Homo sapiens]
Length = 729
Score = 171 bits (432), Expect = 1e-42
Identities = 101/270 (37%), Positives = 145/270 (53%), Gaps = 19/270 (7%)
Query: 25 YEVGKAIGHGSYGSVYEAFYTKQKVMVAVKIISKKKASDDYLNKFLPREIQVMKVLRHKY 84
Y + K IG G++ V A + VA+KII K + + L K RE+++MK+L H
Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLF-REVRIMKILNHPN 114
Query: 85 LINFYRAIESTSRVYIILELAQGGDVLEWIQRYGACSEPLAGKWFSQLTLGIAYLHSKSI 144
++ + IE+ +Y+I+E A GG+V +++ +G E A F Q+ + Y H K I
Sbjct: 115 IVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRI 174
Query: 145 VHRDLKLENLLLDKWENVKISDFGFAKMVPSNQPVGCSPSYRQVNCFSHLSQTYCGSFAY 204
VHRDLK ENLLLD N+KI+DFGF+ + T+CGS Y
Sbjct: 175 VHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKL----------------DTFCGSPPY 218
Query: 205 ACPEILRGLPYNPFLSDTWSMGVILYTLVVAHLPFDDTNLKKLLRETQKEVTFPANHTIS 264
A PE+ +G Y+ D WS+GVILYTLV LPFD NLK+ LRE + +S
Sbjct: 219 AAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKE-LRERVLRGKYRIPFYMS 277
Query: 265 QECKNLILQML-RQATKRATILDIIKDSWV 293
+C+NL+ + L KR T+ I+KD W+
Sbjct: 278 TDCENLLKRFLVLNPIKRGTLEQIMKDRWI 307
>gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo
sapiens]
Length = 795
Score = 170 bits (430), Expect = 2e-42
Identities = 100/270 (37%), Positives = 146/270 (54%), Gaps = 19/270 (7%)
Query: 25 YEVGKAIGHGSYGSVYEAFYTKQKVMVAVKIISKKKASDDYLNKFLPREIQVMKVLRHKY 84
Y + K IG G++ V A + VAVKII K + + L K RE+++MK+L H
Sbjct: 60 YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLF-REVRIMKILNHPN 118
Query: 85 LINFYRAIESTSRVYIILELAQGGDVLEWIQRYGACSEPLAGKWFSQLTLGIAYLHSKSI 144
++ + IE+ +Y+++E A GG+V +++ +G E A F Q+ + Y H K I
Sbjct: 119 IVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYI 178
Query: 145 VHRDLKLENLLLDKWENVKISDFGFAKMVPSNQPVGCSPSYRQVNCFSHLSQTYCGSFAY 204
VHRDLK ENLLLD N+KI+DFGF+ + T+CGS Y
Sbjct: 179 VHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKL----------------DTFCGSPPY 222
Query: 205 ACPEILRGLPYNPFLSDTWSMGVILYTLVVAHLPFDDTNLKKLLRETQKEVTFPANHTIS 264
A PE+ +G Y+ D WS+GVILYTLV LPFD NLK+ LRE + +S
Sbjct: 223 AAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKE-LRERVLRGKYRIPFYMS 281
Query: 265 QECKNLILQML-RQATKRATILDIIKDSWV 293
+C+NL+ ++L KR ++ I+KD W+
Sbjct: 282 TDCENLLKKLLVLNPIKRGSLEQIMKDRWM 311
>gi|116256471 SNF1-like kinase [Homo sapiens]
Length = 783
Score = 169 bits (429), Expect = 2e-42
Identities = 99/270 (36%), Positives = 145/270 (53%), Gaps = 19/270 (7%)
Query: 25 YEVGKAIGHGSYGSVYEAFYTKQKVMVAVKIISKKKASDDYLNKFLPREIQVMKVLRHKY 84
Y++ + +G G++ V A + K VA+KII K + L K RE+Q+MK+L H +
Sbjct: 27 YDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIY-REVQLMKLLNHPH 85
Query: 85 LINFYRAIESTSRVYIILELAQGGDVLEWIQRYGACSEPLAGKWFSQLTLGIAYLHSKSI 144
+I Y+ +E+ +YI+ E A+ G++ +++ G SE A K F Q+ + Y H I
Sbjct: 86 IIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHI 145
Query: 145 VHRDLKLENLLLDKWENVKISDFGFAKMVPSNQPVGCSPSYRQVNCFSHLSQTYCGSFAY 204
VHRDLK ENLLLD ++K++DFGF S +P+ T+CGS Y
Sbjct: 146 VHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLS----------------TWCGSPPY 189
Query: 205 ACPEILRGLPYNPFLSDTWSMGVILYTLVVAHLPFDDTNLKKLLRETQKEVTFPANHTIS 264
A PE+ G Y D WS+GV+LY LV LPFD NL L R+ E F +S
Sbjct: 190 AAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTL-RQRVLEGRFRIPFFMS 248
Query: 265 QECKNLILQML-RQATKRATILDIIKDSWV 293
Q+C++LI +ML +R TI I + W+
Sbjct: 249 QDCESLIRRMLVVDPARRITIAQIRQHRWM 278
>gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]
Length = 778
Score = 169 bits (427), Expect = 4e-42
Identities = 99/278 (35%), Positives = 160/278 (57%), Gaps = 21/278 (7%)
Query: 25 YEVGKAIGHGSYGSVYEAFYTKQKVMVAVKIISKKKASDDYLNKFLPREIQVMKVLRHKY 84
Y + K +G G G V + VA+KI++++K S+ L K + REI ++K++ H +
Sbjct: 34 YRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESVLMK-VEREIAILKLIEHPH 92
Query: 85 LINFYRAIESTSRVYIILELAQGGDVLEWIQRYGACSEPLAGKWFSQLTLGIAYLHSKSI 144
++ + E+ +Y++LE GG++ +++ + G + A K+F Q+ + + HS SI
Sbjct: 93 VLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHSYSI 152
Query: 145 VHRDLKLENLLLDKWENVKISDFGFAKMVPSNQPVGCSPSYRQVNCFSHLSQTYCGSFAY 204
HRDLK ENLLLD+ N++I+DFG A + VG S L +T CGS Y
Sbjct: 153 CHRDLKPENLLLDEKNNIRIADFGMASL-----QVGDS-----------LLETSCGSPHY 196
Query: 205 ACPEILRGLPYNPFLSDTWSMGVILYTLVVAHLPFDDTNLKKLLRETQKEVTFPANHTIS 264
ACPE+++G Y+ +D WS GVIL+ L+V LPFDD NL++LL + ++ V F H I
Sbjct: 197 ACPEVIKGEKYDGRRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGV-FHMPHFIP 255
Query: 265 QECKNLILQMLR-QATKRATILDIIKDSWVL--KFQPE 299
+C++L+ M+ + KR ++ I K W L K +P+
Sbjct: 256 PDCQSLLRGMIEVEPEKRLSLEQIQKHPWYLGGKHEPD 293
>gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo
sapiens]
Length = 688
Score = 164 bits (416), Expect = 8e-41
Identities = 103/307 (33%), Positives = 159/307 (51%), Gaps = 29/307 (9%)
Query: 25 YEVGKAIGHGSYGSVYEAFYTKQKVMVAVKIISKKKASDDYLNKFLPREIQVMKVLRHKY 84
Y + + IG G++ V A + VA+KII K + + L K RE+++MK L H
Sbjct: 59 YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLF-REVRIMKGLNHPN 117
Query: 85 LINFYRAIESTSRVYIILELAQGGDVLEWIQRYGACSEPLAGKWFSQLTLGIAYLHSKSI 144
++ + IE+ +Y+++E A G+V +++ +G E A F Q+ + Y H K+I
Sbjct: 118 IVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNI 177
Query: 145 VHRDLKLENLLLDKWENVKISDFGFAKMVPSNQPVGCSPSYRQVNCFSHLSQTYCGSFAY 204
VHRDLK ENLLLD N+KI+DFGF+ + T+CGS Y
Sbjct: 178 VHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKL----------------DTFCGSPPY 221
Query: 205 ACPEILRGLPYNPFLSDTWSMGVILYTLVVAHLPFDDTNLKKLLRETQKEVTFPANHTIS 264
A PE+ +G Y+ D WS+GVILYTLV LPFD NLK+ LRE + +S
Sbjct: 222 AAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKE-LRERVLRGKYRVPFYMS 280
Query: 265 QECKNLILQML-RQATKRATILDIIKDSWV--------LK--FQPEQPTHEIRLLEAMCQ 313
+C++++ + L KR T+ I+KD W+ LK +PE+ + + +E M
Sbjct: 281 TDCESILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVG 340
Query: 314 LHNTTKQ 320
+ T ++
Sbjct: 341 MGYTREE 347
>gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]
Length = 661
Score = 161 bits (407), Expect = 8e-40
Identities = 98/283 (34%), Positives = 148/283 (52%), Gaps = 27/283 (9%)
Query: 16 YHSLMDEYGYEVGKAIGHGSYGSVYEAFYTKQKVMVAVKIISKKKASDDYLNKFLPREIQ 75
+H ++ YE+ + +G G+YG V A +VA+K I K K D+ + REI+
Sbjct: 46 HHKHNLKHRYELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIE 105
Query: 76 VMKVLRHKYLINFYRAIESTSRVYIILELAQGGDVLEWIQRYGACSEPLAGKWFSQLTLG 135
+M L H ++I+ Y E+ ++ II+E A G++ ++I SE +F Q+
Sbjct: 106 IMSSLNHPHIISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSA 165
Query: 136 IAYLHSKSIVHRDLKLENLLLDKWENVKISDFGFAKMVPSNQPVGCSPSYRQVNCFSHLS 195
+ Y H +VHRDLKLEN+LLD N+KI+DFG + + ++
Sbjct: 166 VHYCHKNGVVHRDLKLENILLDDNCNIKIADFGLSNLYQKDK----------------FL 209
Query: 196 QTYCGSFAYACPEILRGLPYNPFLSDTWSMGVILYTLVVAHLPFDDTNLKKLLRETQ--- 252
QT+CGS YA PEI+ G PY D+W++GV+LYTLV +PFD + K L+R+
Sbjct: 210 QTFCGSPLYASPEIVNGRPYRGPEVDSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGE 269
Query: 253 -KEVTFPANHTISQECKNLILQMLR-QATKRATILDIIKDSWV 293
+E T P+ + + LI ML +RATI DI WV
Sbjct: 270 YREPTQPS------DARGLIRWMLMVNPDRRATIEDIANHWWV 306
>gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens]
Length = 628
Score = 155 bits (392), Expect = 5e-38
Identities = 94/278 (33%), Positives = 146/278 (52%), Gaps = 18/278 (6%)
Query: 16 YHSLMDEYGYEVGKAIGHGSYGSVYEAFYTKQKVMVAVKIISKKKASDDYLNKFLPREIQ 75
+H + YE + +G G+YG V +A + + +VA+K I K K D+ + REI+
Sbjct: 44 HHKHNLRHRYEFLETLGKGTYGKVKKARESSGR-LVAIKSIRKDKIKDEQDLMHIRREIE 102
Query: 76 VMKVLRHKYLINFYRAIESTSRVYIILELAQGGDVLEWIQRYGACSEPLAGKWFSQLTLG 135
+M L H ++I + E++S++ I++E A GD+ ++I SE A +F Q+
Sbjct: 103 IMSSLNHPHIIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSA 162
Query: 136 IAYLHSKSIVHRDLKLENLLLDKWENVKISDFGFAKMVPSNQPVGCSPSYRQVNCFSHLS 195
+ Y H +VHRDLKLEN+LLD N+KI+DFG + + Y Q
Sbjct: 163 VHYCHQNRVVHRDLKLENILLDANGNIKIADFGLSNL------------YHQ----GKFL 206
Query: 196 QTYCGSFAYACPEILRGLPYNPFLSDTWSMGVILYTLVVAHLPFDDTNLKKLLRETQKEV 255
QT+CGS YA PEI+ G PY D+WS+GV+LY LV +PFD + K L+++
Sbjct: 207 QTFCGSPLYASPEIVNGKPYTGPEVDSWSLGVLLYILVHGTMPFDGHDHKILVKQISNG- 265
Query: 256 TFPANHTISQECKNLILQMLRQATKRATILDIIKDSWV 293
+ S C + ++ T+RAT+ D+ WV
Sbjct: 266 AYREPPKPSDACGLIRWLLMVNPTRRATLEDVASHWWV 303
>gi|156105707 SNF related kinase [Homo sapiens]
Length = 765
Score = 152 bits (384), Expect = 4e-37
Identities = 96/282 (34%), Positives = 153/282 (54%), Gaps = 23/282 (8%)
Query: 25 YEVGKAIGHGSYGSVYEAFYTKQKVMVAVKIISKKKASDDYLNKFLPREIQVMKVLRHKY 84
Y++ K +G G + V A + VAVK+I K K D L +E++ MK+++H
Sbjct: 16 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKL-DTLATGHLFQEVRCMKLVQHPN 74
Query: 85 LINFYRAIESTSRVYIILELAQGGDVLEWIQRYG-ACSEPLAGKWFSQLTLGIAYLHSKS 143
++ Y I++ +++Y+ILEL GGD+ ++I ++ +E LA K+F+Q+ I+Y H
Sbjct: 75 IVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLH 134
Query: 144 IVHRDLKLENLLL-DKWENVKISDFGFAKMVPSNQPVGCSPSYRQVNCFSHLSQTYCGSF 202
+VHRDLK EN++ +K VK++DFGF+ + + T CGS
Sbjct: 135 VVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKL----------------TTSCGSL 178
Query: 203 AYACPEILRGLPYNPFLSDTWSMGVILYTLVVAHLPFDDTNLKKLLRETQK-EVTFPANH 261
AY+ PEIL G Y+ D WS+GVIL+ LV PF + N + L + T P++
Sbjct: 179 AYSAPEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSH- 237
Query: 262 TISQECKNLILQML-RQATKRATILDIIKDSWVLKFQPEQPT 302
+S+ECK+LI +ML R +RA++ +I W+ P T
Sbjct: 238 -VSKECKDLITRMLQRDPKRRASLEEIENHPWLQGVDPSPAT 278
>gi|156105705 SNF related kinase [Homo sapiens]
Length = 765
Score = 152 bits (384), Expect = 4e-37
Identities = 96/282 (34%), Positives = 153/282 (54%), Gaps = 23/282 (8%)
Query: 25 YEVGKAIGHGSYGSVYEAFYTKQKVMVAVKIISKKKASDDYLNKFLPREIQVMKVLRHKY 84
Y++ K +G G + V A + VAVK+I K K D L +E++ MK+++H
Sbjct: 16 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKL-DTLATGHLFQEVRCMKLVQHPN 74
Query: 85 LINFYRAIESTSRVYIILELAQGGDVLEWIQRYG-ACSEPLAGKWFSQLTLGIAYLHSKS 143
++ Y I++ +++Y+ILEL GGD+ ++I ++ +E LA K+F+Q+ I+Y H
Sbjct: 75 IVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLH 134
Query: 144 IVHRDLKLENLLL-DKWENVKISDFGFAKMVPSNQPVGCSPSYRQVNCFSHLSQTYCGSF 202
+VHRDLK EN++ +K VK++DFGF+ + + T CGS
Sbjct: 135 VVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKL----------------TTSCGSL 178
Query: 203 AYACPEILRGLPYNPFLSDTWSMGVILYTLVVAHLPFDDTNLKKLLRETQK-EVTFPANH 261
AY+ PEIL G Y+ D WS+GVIL+ LV PF + N + L + T P++
Sbjct: 179 AYSAPEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSH- 237
Query: 262 TISQECKNLILQML-RQATKRATILDIIKDSWVLKFQPEQPT 302
+S+ECK+LI +ML R +RA++ +I W+ P T
Sbjct: 238 -VSKECKDLITRMLQRDPKRRASLEEIENHPWLQGVDPSPAT 278
>gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens]
Length = 651
Score = 152 bits (384), Expect = 4e-37
Identities = 90/275 (32%), Positives = 145/275 (52%), Gaps = 24/275 (8%)
Query: 25 YEVGKAIGHGSYGSVYEAFYTKQKVMVAVKIISKKKASDDYLNKFLPR---EIQVMKVLR 81
YE+ + IG G + V A + MVA+KI+ K D LPR EI+ +K LR
Sbjct: 11 YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSD-----LPRIKTEIEALKNLR 65
Query: 82 HKYLINFYRAIESTSRVYIILELAQGGDVLEWIQRYGACSEPLAGKWFSQLTLGIAYLHS 141
H+++ Y +E+ ++++++LE GG++ ++I SE F Q+ +AY+HS
Sbjct: 66 HQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHS 125
Query: 142 KSIVHRDLKLENLLLDKWENVKISDFGFAKMVPSNQPVGCSPSYRQVNCFSHLSQTYCGS 201
+ HRDLK ENLL D++ +K+ DFG N+ HL QT CGS
Sbjct: 126 QGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDY-------------HL-QTCCGS 171
Query: 202 FAYACPEILRGLPYNPFLSDTWSMGVILYTLVVAHLPFDDTNLKKLLRETQKEVTFPANH 261
AYA PE+++G Y +D WSMG++LY L+ LPFDD N+ L ++ + +
Sbjct: 172 LAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRG-KYDVPK 230
Query: 262 TISQECKNLILQMLR-QATKRATILDIIKDSWVLK 295
+S L+ QML+ KR ++ +++ W+++
Sbjct: 231 WLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQ 265
>gi|46877068 AMP-activated protein kinase alpha 2 catalytic subunit
[Homo sapiens]
Length = 552
Score = 152 bits (383), Expect = 5e-37
Identities = 94/292 (32%), Positives = 156/292 (53%), Gaps = 25/292 (8%)
Query: 25 YEVGKAIGHGSYGSVYEAFYTKQKVMVAVKIISKKKA-SDDYLNKFLPREIQVMKVLRHK 83
Y +G +G G++G V + VAVKI++++K S D + K + REIQ +K+ RH
Sbjct: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGK-IKREIQNLKLFRHP 74
Query: 84 YLINFYRAIESTSRVYIILELAQGGDVLEWIQRYGACSEPLAGKWFSQLTLGIAYLHSKS 143
++I Y+ I + + ++++E GG++ ++I ++G E A + F Q+ + Y H
Sbjct: 75 HIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHM 134
Query: 144 IVHRDLKLENLLLDKWENVKISDFGFAKMVPSNQPVGCSPSYRQVNCFSHLSQTYCGSFA 203
+VHRDLK EN+LLD N KI+DFG + M+ + +T CGS
Sbjct: 135 VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGE----------------FLRTSCGSPN 178
Query: 204 YACPEILRGLPYNPFLSDTWSMGVILYTLVVAHLPFDDTNLKKLLRETQKEVTFPANHTI 263
YA PE++ G Y D WS GVILY L+ LPFDD ++ L ++ + V + + +
Sbjct: 179 YAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEY-L 237
Query: 264 SQECKNLILQMLR-QATKRATILDIIKDSWVLK-----FQPEQPTHEIRLLE 309
++ L++ ML+ KRATI DI + W + PE P+++ +++
Sbjct: 238 NRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVID 289
>gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic
subunit isoform 1 [Homo sapiens]
Length = 559
Score = 149 bits (377), Expect = 3e-36
Identities = 94/292 (32%), Positives = 154/292 (52%), Gaps = 25/292 (8%)
Query: 25 YEVGKAIGHGSYGSVYEAFYTKQKVMVAVKIISKKKA-SDDYLNKFLPREIQVMKVLRHK 83
Y +G +G G++G V + VAVKI++++K S D + K + REIQ +K+ RH
Sbjct: 27 YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGK-IRREIQNLKLFRHP 85
Query: 84 YLINFYRAIESTSRVYIILELAQGGDVLEWIQRYGACSEPLAGKWFSQLTLGIAYLHSKS 143
++I Y+ I + S +++++E GG++ ++I + G E + + F Q+ G+ Y H
Sbjct: 86 HIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHM 145
Query: 144 IVHRDLKLENLLLDKWENVKISDFGFAKMVPSNQPVGCSPSYRQVNCFSHLSQTYCGSFA 203
+VHRDLK EN+LLD N KI+DFG + M+ + +T CGS
Sbjct: 146 VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGE----------------FLRTSCGSPN 189
Query: 204 YACPEILRGLPYNPFLSDTWSMGVILYTLVVAHLPFDDTNLKKLLRETQKEVTFPANHTI 263
YA PE++ G Y D WS GVILY L+ LPFDD ++ L ++ + + + +
Sbjct: 190 YAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQY-L 248
Query: 264 SQECKNLILQMLR-QATKRATILDIIKDSWVLK-----FQPEQPTHEIRLLE 309
+ +L+ ML+ KRATI DI + W + PE P++ +++
Sbjct: 249 NPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMID 300
>gi|23503303 serine/threonine-protein kinase NIM1 [Homo sapiens]
Length = 436
Score = 142 bits (358), Expect = 4e-34
Identities = 86/270 (31%), Positives = 137/270 (50%), Gaps = 19/270 (7%)
Query: 25 YEVGKAIGHGSYGSVYEAFYTKQKVMVAVKIISKKKASDDYLNKFLPREIQVMKVLRHKY 84
Y + IG G++ V ++ K VA+KI+ K K D + L REI M+ L H
Sbjct: 74 YRIRGEIGSGNFSQVKLGIHSLTKEKVAIKILDKTKL-DQKTQRLLSREISSMEKLHHPN 132
Query: 85 LINFYRAIESTSRVYIILELAQGGDVLEWIQRYGACSEPLAGKWFSQLTLGIAYLHSKSI 144
+I Y +E+ S++++++E A GG++ I G SEP + FSQ+ + ++H I
Sbjct: 133 IIRLYEVVETLSKLHLVMEYAGGGELFGKISTEGKLSEPESKLIFSQIVSAVKHMHENQI 192
Query: 145 VHRDLKLENLLLDKWENVKISDFGFAKMVPSNQPVGCSPSYRQVNCFSHLSQTYCGSFAY 204
+HRDLK EN+ VK+ DFGF+ + + + T+CGS Y
Sbjct: 193 IHRDLKAENVFYTSNTCVKVGDFGFSTVSKKGE----------------MLNTFCGSPPY 236
Query: 205 ACPEILRGLPYNPFLSDTWSMGVILYTLVVAHLPFDDTNLKKLLRETQKEVTFPANHTIS 264
A PE+ R Y D W++GV+LY +V +PF + K L+++ E T+ +S
Sbjct: 237 AAPELFRDEHYIGIYVDIWALGVLLYFMVTGTMPFRAETVAK-LKKSILEGTYSVPPHVS 295
Query: 265 QECKNLILQMLRQ-ATKRATILDIIKDSWV 293
+ C LI +L+Q T+R I I+ D W+
Sbjct: 296 EPCHRLIRGVLQQIPTERYGIDCIMNDEWM 325
>gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic
subunit isoform 2 [Homo sapiens]
Length = 574
Score = 140 bits (353), Expect = 2e-33
Identities = 95/307 (30%), Positives = 155/307 (50%), Gaps = 40/307 (13%)
Query: 25 YEVGKAIGHGSYGSVYEAFYTKQKVMVAVKIISKKKA-SDDYLNKFLPREIQVMKVLRHK 83
Y +G +G G++G V + VAVKI++++K S D + K + REIQ +K+ RH
Sbjct: 27 YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGK-IRREIQNLKLFRHP 85
Query: 84 YLINFYRAIESTSRVYIILELAQGGDVLEWIQRYGACS---------------EPLAGKW 128
++I Y+ I + S +++++E GG++ ++I + G S E + +
Sbjct: 86 HIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGSTKELDEKESRRL 145
Query: 129 FSQLTLGIAYLHSKSIVHRDLKLENLLLDKWENVKISDFGFAKMVPSNQPVGCSPSYRQV 188
F Q+ G+ Y H +VHRDLK EN+LLD N KI+DFG + M+ +
Sbjct: 146 FQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGE----------- 194
Query: 189 NCFSHLSQTYCGSFAYACPEILRGLPYNPFLSDTWSMGVILYTLVVAHLPFDDTNLKKLL 248
+T CGS YA PE++ G Y D WS GVILY L+ LPFDD ++ L
Sbjct: 195 -----FLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLF 249
Query: 249 RETQKEVTFPANHTISQECKNLILQMLR-QATKRATILDIIKDSWVLK-----FQPEQPT 302
++ + + + ++ +L+ ML+ KRATI DI + W + PE P+
Sbjct: 250 KKICDGIFYTPQY-LNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPS 308
Query: 303 HEIRLLE 309
+ +++
Sbjct: 309 YSSTMID 315
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.135 0.408
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,094,030
Number of Sequences: 37866
Number of extensions: 506538
Number of successful extensions: 3576
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 704
Number of HSP's successfully gapped in prelim test: 93
Number of HSP's that attempted gapping in prelim test: 1398
Number of HSP's gapped (non-prelim): 899
length of query: 328
length of database: 18,247,518
effective HSP length: 103
effective length of query: 225
effective length of database: 14,347,320
effective search space: 3228147000
effective search space used: 3228147000
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.