Guide to the Human Genome
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Search of human proteins with 42544233

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens]
         (713 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens]            1441   0.0  
gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens]            1441   0.0  
gi|153791330 leucine rich repeat neuronal 1 [Homo sapiens]            652   0.0  
gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens]            638   0.0  
gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens]            638   0.0  
gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens]            638   0.0  
gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom...   185   1e-46
gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo...   167   3e-41
gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens]            167   4e-41
gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo...   163   6e-40
gi|76880480 hypothetical protein LOC9865 [Homo sapiens]               138   2e-32
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s...   134   3e-31
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa...   134   3e-31
gi|31542244 leucine rich repeat and fibronectin type III domain ...   132   1e-30
gi|225579152 insulin-like growth factor binding protein, acid la...   130   6e-30
gi|4826772 insulin-like growth factor binding protein, acid labi...   130   6e-30
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]   128   2e-29
gi|54607118 leucine-rich repeats and immunoglobulin-like domains...   128   2e-29
gi|198041768 synleurin [Homo sapiens]                                 128   2e-29
gi|27363458 leucine rich repeat and fibronectin type III domain ...   126   6e-29
gi|13375646 leucine rich repeat and fibronectin type III domain ...   124   2e-28
gi|4504379 leucine-rich repeat-containing G protein-coupled rece...   124   3e-28
gi|149773484 leucine rich repeat and fibronectin type III domain...   124   4e-28
gi|51317373 netrin-G1 ligand [Homo sapiens]                           123   7e-28
gi|40255157 leucine-rich repeats and immunoglobulin-like domains...   122   2e-27
gi|209862903 leucine-rich repeats and immunoglobulin-like domain...   122   2e-27
gi|7662320 leucine-rich repeats and immunoglobulin-like domains ...   120   4e-27
gi|157694513 leucine-rich repeat-containing G protein-coupled re...   119   1e-26
gi|194440719 chondroadherin-like [Homo sapiens]                       118   2e-26
gi|62912470 leucine-rich repeat-containing G protein-coupled rec...   118   2e-26

>gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens]
          Length = 713

 Score = 1441 bits (3731), Expect = 0.0
 Identities = 713/713 (100%), Positives = 713/713 (100%)

Query: 1   MRLLVAPLLLAWVAGATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFL 60
           MRLLVAPLLLAWVAGATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFL
Sbjct: 1   MRLLVAPLLLAWVAGATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFL 60

Query: 61  TAVPPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLL 120
           TAVPPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLL
Sbjct: 61  TAVPPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLL 120

Query: 121 SLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAI 180
           SLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAI
Sbjct: 121 SLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAI 180

Query: 181 DSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLE 240
           DSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLE
Sbjct: 181 DSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLE 240

Query: 241 SLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVS 300
           SLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVS
Sbjct: 241 SLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVS 300

Query: 301 IDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPN 360
           IDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPN
Sbjct: 301 IDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPN 360

Query: 361 LQEVGLHGNPIRCDCVIRWANATGTRVRFIEPQSTLCAEPPDLQRLPVREVPFREMTDHC 420
           LQEVGLHGNPIRCDCVIRWANATGTRVRFIEPQSTLCAEPPDLQRLPVREVPFREMTDHC
Sbjct: 361 LQEVGLHGNPIRCDCVIRWANATGTRVRFIEPQSTLCAEPPDLQRLPVREVPFREMTDHC 420

Query: 421 LPLISPRSFPPSLQVASGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEG 480
           LPLISPRSFPPSLQVASGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEG
Sbjct: 421 LPLISPRSFPPSLQVASGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEG 480

Query: 481 TLELRRVTAEEAGLYTCVAQNLVGADTKTVSVVVGRALLQPGRDEGQGLELRVQETHPYH 540
           TLELRRVTAEEAGLYTCVAQNLVGADTKTVSVVVGRALLQPGRDEGQGLELRVQETHPYH
Sbjct: 481 TLELRRVTAEEAGLYTCVAQNLVGADTKTVSVVVGRALLQPGRDEGQGLELRVQETHPYH 540

Query: 541 ILLSWVTPPNTVSTNLTWSSASSLRGQGATALARLPRGTHSYNITRLLQATEYWACLQVA 600
           ILLSWVTPPNTVSTNLTWSSASSLRGQGATALARLPRGTHSYNITRLLQATEYWACLQVA
Sbjct: 541 ILLSWVTPPNTVSTNLTWSSASSLRGQGATALARLPRGTHSYNITRLLQATEYWACLQVA 600

Query: 601 FADAHTQLACVWARTKEATSCHRALGDRPGLIAILALAVLLLAAGLAAHLGTGQPRKGVG 660
           FADAHTQLACVWARTKEATSCHRALGDRPGLIAILALAVLLLAAGLAAHLGTGQPRKGVG
Sbjct: 601 FADAHTQLACVWARTKEATSCHRALGDRPGLIAILALAVLLLAAGLAAHLGTGQPRKGVG 660

Query: 661 GRRPLPPAWAFWGWSAPSVRVVSAPLVLPWNPGRKLPRSSEGETLLPPLSQNS 713
           GRRPLPPAWAFWGWSAPSVRVVSAPLVLPWNPGRKLPRSSEGETLLPPLSQNS
Sbjct: 661 GRRPLPPAWAFWGWSAPSVRVVSAPLVLPWNPGRKLPRSSEGETLLPPLSQNS 713


>gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens]
          Length = 713

 Score = 1441 bits (3731), Expect = 0.0
 Identities = 713/713 (100%), Positives = 713/713 (100%)

Query: 1   MRLLVAPLLLAWVAGATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFL 60
           MRLLVAPLLLAWVAGATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFL
Sbjct: 1   MRLLVAPLLLAWVAGATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFL 60

Query: 61  TAVPPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLL 120
           TAVPPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLL
Sbjct: 61  TAVPPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLL 120

Query: 121 SLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAI 180
           SLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAI
Sbjct: 121 SLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAI 180

Query: 181 DSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLE 240
           DSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLE
Sbjct: 181 DSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLE 240

Query: 241 SLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVS 300
           SLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVS
Sbjct: 241 SLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVS 300

Query: 301 IDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPN 360
           IDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPN
Sbjct: 301 IDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPN 360

Query: 361 LQEVGLHGNPIRCDCVIRWANATGTRVRFIEPQSTLCAEPPDLQRLPVREVPFREMTDHC 420
           LQEVGLHGNPIRCDCVIRWANATGTRVRFIEPQSTLCAEPPDLQRLPVREVPFREMTDHC
Sbjct: 361 LQEVGLHGNPIRCDCVIRWANATGTRVRFIEPQSTLCAEPPDLQRLPVREVPFREMTDHC 420

Query: 421 LPLISPRSFPPSLQVASGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEG 480
           LPLISPRSFPPSLQVASGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEG
Sbjct: 421 LPLISPRSFPPSLQVASGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEG 480

Query: 481 TLELRRVTAEEAGLYTCVAQNLVGADTKTVSVVVGRALLQPGRDEGQGLELRVQETHPYH 540
           TLELRRVTAEEAGLYTCVAQNLVGADTKTVSVVVGRALLQPGRDEGQGLELRVQETHPYH
Sbjct: 481 TLELRRVTAEEAGLYTCVAQNLVGADTKTVSVVVGRALLQPGRDEGQGLELRVQETHPYH 540

Query: 541 ILLSWVTPPNTVSTNLTWSSASSLRGQGATALARLPRGTHSYNITRLLQATEYWACLQVA 600
           ILLSWVTPPNTVSTNLTWSSASSLRGQGATALARLPRGTHSYNITRLLQATEYWACLQVA
Sbjct: 541 ILLSWVTPPNTVSTNLTWSSASSLRGQGATALARLPRGTHSYNITRLLQATEYWACLQVA 600

Query: 601 FADAHTQLACVWARTKEATSCHRALGDRPGLIAILALAVLLLAAGLAAHLGTGQPRKGVG 660
           FADAHTQLACVWARTKEATSCHRALGDRPGLIAILALAVLLLAAGLAAHLGTGQPRKGVG
Sbjct: 601 FADAHTQLACVWARTKEATSCHRALGDRPGLIAILALAVLLLAAGLAAHLGTGQPRKGVG 660

Query: 661 GRRPLPPAWAFWGWSAPSVRVVSAPLVLPWNPGRKLPRSSEGETLLPPLSQNS 713
           GRRPLPPAWAFWGWSAPSVRVVSAPLVLPWNPGRKLPRSSEGETLLPPLSQNS
Sbjct: 661 GRRPLPPAWAFWGWSAPSVRVVSAPLVLPWNPGRKLPRSSEGETLLPPLSQNS 713


>gi|153791330 leucine rich repeat neuronal 1 [Homo sapiens]
          Length = 716

 Score =  652 bits (1681), Expect = 0.0
 Identities = 328/591 (55%), Positives = 425/591 (71%), Gaps = 6/591 (1%)

Query: 29  CPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQSE 88
           CP  C C+IRPW+TP+S+YREATTVDCNDL LT +P  L + TQ LLLQSN+I +    E
Sbjct: 32  CPQLCVCEIRPWFTPQSTYREATTVDCNDLRLTRIPSNLSSDTQVLLLQSNNIAKT-VDE 90

Query: 89  LGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELYL 148
           L  L NLTELD SQN+F++ ++     L QL +LHLEENQ+T + D+    L++LQELY+
Sbjct: 91  LQQLFNLTELDFSQNNFTNIKEVGLANLTQLTTLHLEENQITEMTDYCLQDLSNLQELYI 150

Query: 149 NHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMN 208
           NHNQ+  I+  AF+GL NLLRLHLNSN L+ IDSRWF+  PNLEILMIG N V  ILDMN
Sbjct: 151 NHNQISTISAHAFAGLKNLLRLHLNSNKLKVIDSRWFDSTPNLEILMIGENPVIGILDMN 210

Query: 209 FRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDL 268
           F+PLANLRSLVLAGM L +I   AL GL SLESLSFYDN+L +VP+ AL++VP LKFLDL
Sbjct: 211 FKPLANLRSLVLAGMYLTDIPGNALVGLDSLESLSFYDNKLVKVPQLALQKVPNLKFLDL 270

Query: 269 NKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNPRLSFIHP 328
           NKNP+ ++  GDF NML LKELG+NNM ELVS+D++AL NLPELTKL+ TNNP+LS+IH 
Sbjct: 271 NKNPIHKIQEGDFKNMLRLKELGINNMGELVSVDRYALDNLPELTKLEATNNPKLSYIHR 330

Query: 329 RAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRCDCVIRWANATGTRVR 388
            AF  +P +E+LMLNNNAL+A++Q+TVESLPNL+E+ +H NP+RCDCVI W N+  T +R
Sbjct: 331 LAFRSVPALESLMLNNNALNAIYQKTVESLPNLREISIHSNPLRCDCVIHWINSNKTNIR 390

Query: 389 FIEPQSTLCAEPPDLQRLPVREVPFREMTDHCLPLISPRSFPPSLQVASGESMVLHCRAL 448
           F+EP S  CA PP+ +   V+EV  ++ ++ CLP+IS  SFP  L V  G ++ L CRA+
Sbjct: 391 FMEPLSMFCAMPPEYKGHQVKEVLIQDSSEQCLPMISHDSFPNRLNVDIGTTVFLDCRAM 450

Query: 449 AEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEGTLELRRVTAEEAGLYTCVAQNLVGADTK 508
           AEPEPEIYWVTP G ++T      +Y++  EGTLE+  +  E++G YTCVAQN+ GADT+
Sbjct: 451 AEPEPEIYWVTPIGNKITVETLSDKYKLSSEGTLEISNIQIEDSGRYTCVAQNVQGADTR 510

Query: 509 TVSVVVGRALLQPGRDEGQGLELRVQETHPYHILLSWVTPPNTVSTNLTWSSAS-SLRGQ 567
             ++ V   LL    D  Q L++ V++T  + IL+SW    N +++NL WSSA+  +   
Sbjct: 511 VATIKVNGTLL----DGTQVLKIYVKQTESHSILVSWKVNSNVMTSNLKWSSATMKIDNP 566

Query: 568 GATALARLPRGTHSYNITRLLQATEYWACLQVAFADAHTQLACVWARTKEA 618
             T  AR+P   H YN+T L  +T+Y  CL V+     TQ +CV   TK A
Sbjct: 567 HITYTARVPVDVHEYNLTHLQPSTDYEVCLTVSNIHQQTQKSCVNVTTKNA 617


>gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens]
          Length = 708

 Score =  638 bits (1645), Expect = 0.0
 Identities = 322/633 (50%), Positives = 426/633 (67%), Gaps = 16/633 (2%)

Query: 17  TAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQTLLL 76
           T  V  V   V CP  C C+IRPW+TPRS Y EA+TVDCNDL L   P  LPA TQ LLL
Sbjct: 17  TTLVQAVDKKVDCPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPANTQILLL 76

Query: 77  QSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHS 136
           Q+N+I +++ S   +  NLT LDLSQN+ S   + +   +PQLLS++LEEN+LT L +  
Sbjct: 77  QTNNIAKIEYST-DFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKC 135

Query: 137 FAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMI 196
            + L++LQELY+NHN L  I+P AF GL NLLRLHLNSN L+ I+S+WF+ LPNLEILMI
Sbjct: 136 LSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMI 195

Query: 197 GGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARVPRRA 256
           G N +  I DMNF+PL NLRSLV+AG+NL EI D AL GL++LES+SFYDN+L +VP  A
Sbjct: 196 GENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLIKVPHVA 255

Query: 257 LEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLD 316
           L++V  LKFLDLNKNP+ R+  GDF+NMLHLKELG+NNM EL+SID  A+ NLP+L K++
Sbjct: 256 LQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNLPDLRKIE 315

Query: 317 ITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRCDCV 376
            TNNPRLS+IHP AF  LP++E+LMLN+NALSAL+  T+ESLPNL+E+ +H NPIRCDCV
Sbjct: 316 ATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISIHSNPIRCDCV 375

Query: 377 IRWANATGTRVRFIEPQSTLCAEPPDLQRLPVREVPFREMTDHCLPLISPRSFPPSLQVA 436
           IRW N   T +RF+EP S  C +PP+ Q   VR+V FR+M + CLPLI+P SFP +L V 
Sbjct: 376 IRWMNMNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDMMEICLPLIAPESFPSNLNVE 435

Query: 437 SGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEGTLELRRVTAEEAGLYT 496
           +G  +  HCRA AEP+PEIYW+TP+G +L P     ++ V+ EGTL++  VT +E GLYT
Sbjct: 436 AGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEGTLDINGVTPKEGGLYT 495

Query: 497 CVAQNLVGADTKTVSVVVGRALLQPGRDEGQGLELRVQETHPYHILLSWVTPPNTVSTNL 556
           C+A NLVGAD K+V + V  +  Q   D    L +++++     +L+SW      + +++
Sbjct: 496 CIATNLVGADLKSVMIKVDGSFPQ---DNNGSLNIKIRDIQANSVLVSWKASSKILKSSV 552

Query: 557 TWSSASSLRGQGATALARLPRGTHSYNITRLLQATEYWACLQVAFADAHTQLACVWARTK 616
            W++        A   AR+P     YN+T L  +TEY  C+ +       +  CV   TK
Sbjct: 553 KWTAFVKTENSHAAQSARIPSDVKVYNLTHLNPSTEYKICIDIPTIYQKNRKKCVNVTTK 612

Query: 617 ------------EATSCHRALGDRPGLIAILAL 637
                         T+    LG   G+I ++ L
Sbjct: 613 GLHPDQKEYEKNNTTTLMACLGGLLGIIGVICL 645


>gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens]
          Length = 708

 Score =  638 bits (1645), Expect = 0.0
 Identities = 322/633 (50%), Positives = 426/633 (67%), Gaps = 16/633 (2%)

Query: 17  TAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQTLLL 76
           T  V  V   V CP  C C+IRPW+TPRS Y EA+TVDCNDL L   P  LPA TQ LLL
Sbjct: 17  TTLVQAVDKKVDCPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPANTQILLL 76

Query: 77  QSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHS 136
           Q+N+I +++ S   +  NLT LDLSQN+ S   + +   +PQLLS++LEEN+LT L +  
Sbjct: 77  QTNNIAKIEYST-DFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKC 135

Query: 137 FAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMI 196
            + L++LQELY+NHN L  I+P AF GL NLLRLHLNSN L+ I+S+WF+ LPNLEILMI
Sbjct: 136 LSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMI 195

Query: 197 GGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARVPRRA 256
           G N +  I DMNF+PL NLRSLV+AG+NL EI D AL GL++LES+SFYDN+L +VP  A
Sbjct: 196 GENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLIKVPHVA 255

Query: 257 LEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLD 316
           L++V  LKFLDLNKNP+ R+  GDF+NMLHLKELG+NNM EL+SID  A+ NLP+L K++
Sbjct: 256 LQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNLPDLRKIE 315

Query: 317 ITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRCDCV 376
            TNNPRLS+IHP AF  LP++E+LMLN+NALSAL+  T+ESLPNL+E+ +H NPIRCDCV
Sbjct: 316 ATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISIHSNPIRCDCV 375

Query: 377 IRWANATGTRVRFIEPQSTLCAEPPDLQRLPVREVPFREMTDHCLPLISPRSFPPSLQVA 436
           IRW N   T +RF+EP S  C +PP+ Q   VR+V FR+M + CLPLI+P SFP +L V 
Sbjct: 376 IRWMNMNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDMMEICLPLIAPESFPSNLNVE 435

Query: 437 SGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEGTLELRRVTAEEAGLYT 496
           +G  +  HCRA AEP+PEIYW+TP+G +L P     ++ V+ EGTL++  VT +E GLYT
Sbjct: 436 AGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEGTLDINGVTPKEGGLYT 495

Query: 497 CVAQNLVGADTKTVSVVVGRALLQPGRDEGQGLELRVQETHPYHILLSWVTPPNTVSTNL 556
           C+A NLVGAD K+V + V  +  Q   D    L +++++     +L+SW      + +++
Sbjct: 496 CIATNLVGADLKSVMIKVDGSFPQ---DNNGSLNIKIRDIQANSVLVSWKASSKILKSSV 552

Query: 557 TWSSASSLRGQGATALARLPRGTHSYNITRLLQATEYWACLQVAFADAHTQLACVWARTK 616
            W++        A   AR+P     YN+T L  +TEY  C+ +       +  CV   TK
Sbjct: 553 KWTAFVKTENSHAAQSARIPSDVKVYNLTHLNPSTEYKICIDIPTIYQKNRKKCVNVTTK 612

Query: 617 ------------EATSCHRALGDRPGLIAILAL 637
                         T+    LG   G+I ++ L
Sbjct: 613 GLHPDQKEYEKNNTTTLMACLGGLLGIIGVICL 645


>gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens]
          Length = 708

 Score =  638 bits (1645), Expect = 0.0
 Identities = 322/633 (50%), Positives = 426/633 (67%), Gaps = 16/633 (2%)

Query: 17  TAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQTLLL 76
           T  V  V   V CP  C C+IRPW+TPRS Y EA+TVDCNDL L   P  LPA TQ LLL
Sbjct: 17  TTLVQAVDKKVDCPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPANTQILLL 76

Query: 77  QSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHS 136
           Q+N+I +++ S   +  NLT LDLSQN+ S   + +   +PQLLS++LEEN+LT L +  
Sbjct: 77  QTNNIAKIEYST-DFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKC 135

Query: 137 FAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMI 196
            + L++LQELY+NHN L  I+P AF GL NLLRLHLNSN L+ I+S+WF+ LPNLEILMI
Sbjct: 136 LSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMI 195

Query: 197 GGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARVPRRA 256
           G N +  I DMNF+PL NLRSLV+AG+NL EI D AL GL++LES+SFYDN+L +VP  A
Sbjct: 196 GENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLIKVPHVA 255

Query: 257 LEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLD 316
           L++V  LKFLDLNKNP+ R+  GDF+NMLHLKELG+NNM EL+SID  A+ NLP+L K++
Sbjct: 256 LQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNLPDLRKIE 315

Query: 317 ITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRCDCV 376
            TNNPRLS+IHP AF  LP++E+LMLN+NALSAL+  T+ESLPNL+E+ +H NPIRCDCV
Sbjct: 316 ATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISIHSNPIRCDCV 375

Query: 377 IRWANATGTRVRFIEPQSTLCAEPPDLQRLPVREVPFREMTDHCLPLISPRSFPPSLQVA 436
           IRW N   T +RF+EP S  C +PP+ Q   VR+V FR+M + CLPLI+P SFP +L V 
Sbjct: 376 IRWMNMNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDMMEICLPLIAPESFPSNLNVE 435

Query: 437 SGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEGTLELRRVTAEEAGLYT 496
           +G  +  HCRA AEP+PEIYW+TP+G +L P     ++ V+ EGTL++  VT +E GLYT
Sbjct: 436 AGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEGTLDINGVTPKEGGLYT 495

Query: 497 CVAQNLVGADTKTVSVVVGRALLQPGRDEGQGLELRVQETHPYHILLSWVTPPNTVSTNL 556
           C+A NLVGAD K+V + V  +  Q   D    L +++++     +L+SW      + +++
Sbjct: 496 CIATNLVGADLKSVMIKVDGSFPQ---DNNGSLNIKIRDIQANSVLVSWKASSKILKSSV 552

Query: 557 TWSSASSLRGQGATALARLPRGTHSYNITRLLQATEYWACLQVAFADAHTQLACVWARTK 616
            W++        A   AR+P     YN+T L  +TEY  C+ +       +  CV   TK
Sbjct: 553 KWTAFVKTENSHAAQSARIPSDVKVYNLTHLNPSTEYKICIDIPTIYQKNRKKCVNVTTK 612

Query: 617 ------------EATSCHRALGDRPGLIAILAL 637
                         T+    LG   G+I ++ L
Sbjct: 613 GLHPDQKEYEKNNTTTLMACLGGLLGIIGVICL 645


>gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo
           sapiens]
          Length = 592

 Score =  185 bits (470), Expect = 1e-46
 Identities = 151/513 (29%), Positives = 230/513 (44%), Gaps = 67/513 (13%)

Query: 29  CPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQSE 88
           CP +C C +           +   V C    LTAVP  +PA T+ L              
Sbjct: 25  CPARCECTV-----------QTRAVACTRRRLTAVPDGIPAETRLL-------------- 59

Query: 89  LGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELYL 148
                     +LS+N        D  ALP L  L L EN +  +E  +FA L  L+ L L
Sbjct: 60  ----------ELSRNRIRCLNPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRL 109

Query: 149 NHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMN 208
             NQL  I P  F+ L NL  L L+ N L  +    F+ L +L  L +G N +  +    
Sbjct: 110 RGNQLKLIPPGVFTRLDNLTLLDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRA 169

Query: 209 FRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDL 268
           F  L  L  L L   NL  +S  +L  L+SL +L      +A +  +   ++PGL  L++
Sbjct: 170 FAGLLALEELTLERCNLTALSGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEI 229

Query: 269 NKNP-LQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNP------ 321
           +  P L+ V  G     L+L  L + +   + ++   AL +   LT L++++NP      
Sbjct: 230 DNWPLLEEVAAGSLRG-LNLTSLSVTH-TNITAVPAAALRHQAHLTCLNLSHNPISTVPR 287

Query: 322 -----------------RLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEV 364
                             L+ + P+AF  L Q+  L L+NN LS L + T  S+  L+ +
Sbjct: 288 GSFRDLVRLRELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETL 347

Query: 365 GLHGNPIRCDCVIRWANATGTRVRFIEPQSTLCAEPPDLQRLPVREVPFREMTDHCL--- 421
            + GNP+ CDC + W       + F + +   CA P +++   +R +P   + ++ +   
Sbjct: 348 RVDGNPLACDCRLLWIVQRRKTLNF-DGRLPACATPAEVRGDALRNLPDSVLFEYFVCRK 406

Query: 422 PLISPRSFPPSLQVASGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEGT 481
           P I  R     +   +GE +   CRA  EP P + WVTP    +T   AGR  RV P GT
Sbjct: 407 PKIRERRL-QRVTATAGEDVRFLCRAEGEPAPTVAWVTPQHRPVTATSAGRA-RVLPGGT 464

Query: 482 LELRRVTAEEAGLYTCVAQNLVGADTKTVSVVV 514
           LE++    +++G YTCVA N  G DT   ++ V
Sbjct: 465 LEIQDARPQDSGTYTCVASNAGGNDTYFATLTV 497


>gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo
           sapiens]
          Length = 606

 Score =  167 bits (423), Expect = 3e-41
 Identities = 140/518 (27%), Positives = 224/518 (43%), Gaps = 73/518 (14%)

Query: 27  VPCPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQ 86
           + CP +C C             +  +V C+   L A+P  +P  T+ L            
Sbjct: 26  IGCPARCECSA-----------QNKSVSCHRRRLIAIPEGIPIETKIL------------ 62

Query: 87  SELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQEL 146
                       DLS+N        +F + P L  + L +N +  +E  +F  L +L+ L
Sbjct: 63  ------------DLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSL 110

Query: 147 YLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILD 206
            L  N+L  +    F+GLSNL +L ++ N +  +    F+ L NL+ L +G N +  I  
Sbjct: 111 RLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISH 170

Query: 207 MNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARVPRRALEQVPGLKFL 266
             F  L +L  L L   NL  +   AL  L+SL SL      +  +P  A +++  LK L
Sbjct: 171 RAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHL 230

Query: 267 DLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNP----- 321
           +++  PL  + P +    L+L  L + N   L ++   A  +L  LT L+++ NP     
Sbjct: 231 EIDYWPLLDMMPANSLYGLNLTSLSVTN-TNLSTVPFLAFKHLVYLTHLNLSYNPISTIE 289

Query: 322 ------------------RLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQE 363
                             +L  I P +F  L  +  L ++ N L  L +    S   L+ 
Sbjct: 290 AGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEV 349

Query: 364 VGLHGNPIRCDCVIRWANATGTRVRFIEPQSTLCAEPPDLQRLPVREVPFREMTDHCLPL 423
           + ++ NP+ CDC + W       ++F   Q  +CA P       +RE  F++     L  
Sbjct: 350 LSINNNPLACDCRLLWILQRQPTLQF-GGQQPMCAGPD-----TIRERSFKDFHSTALSF 403

Query: 424 I----SPRSFPPSLQ---VASGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRV 476
                 P+     LQ   V  G+++ L C A  +P+P I WVTP    +T    GR   V
Sbjct: 404 YFTCKKPKIREKKLQHLLVDEGQTVQLECSADGDPQPVISWVTPRRRFITTKSNGRA-TV 462

Query: 477 YPEGTLELRRVTAEEAGLYTCVAQNLVGADTKTVSVVV 514
             +GTLE+R    +++G+Y C+A N  G DT T S+ V
Sbjct: 463 LGDGTLEIRFAQDQDSGMYVCIASNAAGNDTFTASLTV 500


>gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens]
          Length = 620

 Score =  167 bits (422), Expect = 4e-41
 Identities = 148/540 (27%), Positives = 235/540 (43%), Gaps = 77/540 (14%)

Query: 1   MRLLVAPLLLAW------VAGATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVD 54
           +R + +PLL  W      V G+  +         CPP+C C  +              V 
Sbjct: 12  VRSMPSPLLACWQPILLLVLGSVLSGSATG----CPPRCECSAQD-----------RAVL 56

Query: 55  CNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFH 114
           C+     AVP  +P  T+ L L  N I  ++Q E     +L EL+L++N  S      F+
Sbjct: 57  CHRKRFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFN 116

Query: 115 ------------------------ALPQLLSLHLEENQLTRLEDHSFAGLASLQELYLNH 150
                                    L  L  L + EN++  L D+ F  L +L+ L +  
Sbjct: 117 NLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGD 176

Query: 151 NQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFR 210
           N L  I+ RAFSGL++L +L L    L +I +     L  L +L +    ++AI D +F+
Sbjct: 177 NDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFK 236

Query: 211 PLANLRSLVLAGM-NLREISDYALEGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDLN 269
            L  L+ L ++    L  ++   L GL +L SLS     L  VP  A+  +  L+FL+L+
Sbjct: 237 RLYRLKVLEISHWPYLDTMTPNCLYGL-NLTSLSITHCNLTAVPYLAVRHLVYLRFLNLS 295

Query: 270 KNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNPRLSFIHPR 329
            NP+  +      +MLH          EL+ + +  LV              +L+ + P 
Sbjct: 296 YNPISTIE----GSMLH----------ELLRLQEIQLV------------GGQLAVVEPY 329

Query: 330 AFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRCDCVIRWANATGTRVRF 389
           AF  L  +  L ++ N L+ L +    S+ NL+ + L  NP+ CDC + W      R+ F
Sbjct: 330 AFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNPLACDCRLLWVFRRRWRLNF 389

Query: 390 IEPQSTLCAEPPDLQRLPVREVPFREMTDH--CLPLISPRSFPPSLQVASGESMVLHCRA 447
              Q T CA P  +Q    ++ P   + ++  C            + V  G ++   CRA
Sbjct: 390 NRQQPT-CATPEFVQGKEFKDFPDVLLPNYFTCRRARIRDRKAQQVFVDEGHTVQFVCRA 448

Query: 448 LAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEGTLELRRVTAEEAGLYTCVAQNLVGADT 507
             +P P I W++P    L  A +  R  V+P+GTLE+R    ++ G Y C+A N  G D+
Sbjct: 449 DGDPPPAILWLSPR-KHLVSAKSNGRLTVFPDGTLEVRYAQVQDNGTYLCIAANAGGNDS 507


>gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo
           sapiens]
          Length = 593

 Score =  163 bits (412), Expect = 6e-40
 Identities = 149/506 (29%), Positives = 210/506 (41%), Gaps = 69/506 (13%)

Query: 29  CPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQSE 88
           CP  C C  +P             V C    L AVP  LP  T+ L L  N +  + Q  
Sbjct: 31  CPAVCDCTSQP-----------QAVLCGHRQLEAVPGGLPLDTELLDLSGNRLWGLQQGM 79

Query: 89  LGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELYL 148
           L  L+ L ELDLS N  S      FH L  LL+L L+ N+L  +    F+GL++L  L L
Sbjct: 80  LSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGVFSGLSALTLLDL 139

Query: 149 NHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMN 208
             NQ+      AF  L +L +L                         +G N +  +    
Sbjct: 140 RLNQIVLFLDGAFGELGSLQKLE------------------------VGDNHLVFVAPGA 175

Query: 209 FRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDL 268
           F  LA L +L L   NL  +   AL  L +L +L   +  + R+P  AL  +  LK L++
Sbjct: 176 FAGLAKLSTLTLERCNLSTVPGLALARLPALVALRLRELDIGRLPAGALRGLGQLKELEI 235

Query: 269 NKNP-LQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNP------ 321
           +  P L+ + PG     L+L  L +     L S+   AL +L  L  LD++ NP      
Sbjct: 236 HLWPSLEALDPGSLVG-LNLSSLAITRC-NLSSVPFQALYHLSFLRVLDLSQNPISAIPA 293

Query: 322 -----------------RLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEV 364
                             L+ I   AFH L     L + +NAL  L +    S   L  +
Sbjct: 294 RRLSPLVRLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLVTL 353

Query: 365 GLHGNPIRCDCVIRWANATGTRVRF-IEPQSTLCAEPPDLQRLPVREVPFREMTDH--CL 421
            L GNP+ CDC + W       + F + P +  CA P  +Q   ++E        H  C 
Sbjct: 354 RLSGNPLTCDCRLLWLLRLRRHLDFGMSPPA--CAGPHHVQGKSLKEFSDILPPGHFTCK 411

Query: 422 PLISPRSFPPSLQVASGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEGT 481
           P +  +S P  +    G   V  C    +P P + W+ P G  L    AG R RV  +GT
Sbjct: 412 PALIRKSGPRWVIAEEGGHAVFSCSGDGDPAPTVSWMRPHGAWL--GRAG-RVRVLEDGT 468

Query: 482 LELRRVTAEEAGLYTCVAQNLVGADT 507
           LE+R V   + G Y CV  N+ G D+
Sbjct: 469 LEIRSVQLRDRGAYVCVVSNVAGNDS 494


>gi|76880480 hypothetical protein LOC9865 [Homo sapiens]
          Length = 811

 Score =  138 bits (347), Expect = 2e-32
 Identities = 123/406 (30%), Positives = 170/406 (41%), Gaps = 27/406 (6%)

Query: 9   LLAWVAGATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPAL- 67
           LL  V G  A  P+      CP +C CQ                + C +  L  VP    
Sbjct: 9   LLLVVCGCLALPPLA--EPVCPERCDCQ------------HPQHLLCTNRGLRVVPKTSS 54

Query: 68  ---PAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHL 124
              P    T  L  N I  +   +   L  L  LDL  N         F  L +L  L+L
Sbjct: 55  LPSPHDVLTYSLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYL 114

Query: 125 EENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRW 184
             N L  L   + A L  L+ LY N N++ R++  +F GL +L++L L+ N L A+    
Sbjct: 115 GNNLLQALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAV 174

Query: 185 FEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYA--LEGLQSLESL 242
           F  L NL  L +  N++  +    F  L  LR L L+   L+    +A     L+SL SL
Sbjct: 175 FAPLGNLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSL 234

Query: 243 SFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSID 302
               N L  +  R  + +P L  L L  N L  + P  F  +  L+EL L     L  + 
Sbjct: 235 ILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEG-NRLSQLP 293

Query: 303 KFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQ 362
              L  L  L  LD++ N  LS +HP  F HL ++  L L NNALSAL      + P L 
Sbjct: 294 TALLEPLHSLEALDLSGN-ELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPALY 352

Query: 363 EVGLHGNPIRCDCVI----RWANATGTRVRFIEPQSTLCAEPPDLQ 404
            + L GN   CDC +    RW     ++ R +      C  PP L+
Sbjct: 353 RLDLDGNGWTCDCRLRGLKRWMGDWHSQGRLL-TVFVQCRHPPALR 397


>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
           sapiens]
          Length = 587

 Score =  134 bits (337), Expect = 3e-31
 Identities = 111/368 (30%), Positives = 163/368 (44%), Gaps = 38/368 (10%)

Query: 29  CPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQSE 88
           CP +C C              A+ V+C    + AVP  LP    +L + +  I  +++S 
Sbjct: 31  CPSECTCS------------RASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESP 78

Query: 89  LGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELYL 148
              ++ L  L + +N  S      F  L  L  L L  N+L  L    F GL SL+ L L
Sbjct: 79  FLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLL 138

Query: 149 NHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMN 208
           + NQL +I P  FS  SNL  L L+ N L  I    F+ L  L  L +G N +  I    
Sbjct: 139 SSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRV 198

Query: 209 FRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQ-------------------- 248
           F+ L NL+ L L    L +I     +GL +L+ L+   NQ                    
Sbjct: 199 FQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYL 258

Query: 249 ----LARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKF 304
               ++++P     Q+P L  L L  N L+ +  G F  M +L+EL L +   + S+   
Sbjct: 259 SNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYD-NHISSLPDN 317

Query: 305 ALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEV 364
              NL +L  L ++ N ++SFI P AF+ L ++  L L+ NAL  L       L NLQ +
Sbjct: 318 VFSNLRQLQVLILSRN-QISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNI 376

Query: 365 GLHGNPIR 372
            L  N +R
Sbjct: 377 SLQNNRLR 384



 Score =  125 bits (315), Expect = 1e-28
 Identities = 91/303 (30%), Positives = 138/303 (45%), Gaps = 2/303 (0%)

Query: 72  QTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTR 131
           ++LLL SN ++++  +     +NL EL L  N      D  F  L  L  L+L +N LT 
Sbjct: 134 ESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTH 193

Query: 132 LEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNL 191
           +    F  L +LQ L L  N+L  I    F GL NL  L L  N +  +    F    NL
Sbjct: 194 ISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNL 253

Query: 192 EILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLAR 251
           + L +  N +  +    F  L  L  L L G +L+E+S      + +L  L  YDN ++ 
Sbjct: 254 QRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISS 313

Query: 252 VPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPE 311
           +P      +  L+ L L++N +  + PG F  +  L+EL L+    L  +D      L  
Sbjct: 314 LPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHT-NALQDLDGNVFRMLAN 372

Query: 312 LTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPI 371
           L  + + NN RL  +    F ++  +  + L NN L  L     + L  L E+ L+ NP 
Sbjct: 373 LQNISLQNN-RLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPW 431

Query: 372 RCD 374
           RCD
Sbjct: 432 RCD 434



 Score = 98.2 bits (243), Expect = 2e-20
 Identities = 74/252 (29%), Positives = 117/252 (46%), Gaps = 1/252 (0%)

Query: 70  GTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQL 129
           G   L L  NS+  +      +L NL  L L +N  +D     F  L  L  L L++NQ+
Sbjct: 180 GLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQI 239

Query: 130 TRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLP 189
             L    F    +LQ LYL++N + ++ P  F  L  L RL L  N L+ +    F  +P
Sbjct: 240 GLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMP 299

Query: 190 NLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQL 249
           NL  L +  N + ++ D  F  L  L+ L+L+   +  IS  A  GL  L  LS + N L
Sbjct: 300 NLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNAL 359

Query: 250 ARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNL 309
             +       +  L+ + L  N L+++    FAN+  L  + L N  +L ++      +L
Sbjct: 360 QDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQN-NQLENLPLGIFDHL 418

Query: 310 PELTKLDITNNP 321
            +L +L + +NP
Sbjct: 419 GKLCELRLYDNP 430


>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
           sapiens]
          Length = 581

 Score =  134 bits (337), Expect = 3e-31
 Identities = 111/368 (30%), Positives = 163/368 (44%), Gaps = 38/368 (10%)

Query: 29  CPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQSE 88
           CP +C C              A+ V+C    + AVP  LP    +L + +  I  +++S 
Sbjct: 25  CPSECTCS------------RASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESP 72

Query: 89  LGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELYL 148
              ++ L  L + +N  S      F  L  L  L L  N+L  L    F GL SL+ L L
Sbjct: 73  FLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLL 132

Query: 149 NHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMN 208
           + NQL +I P  FS  SNL  L L+ N L  I    F+ L  L  L +G N +  I    
Sbjct: 133 SSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRV 192

Query: 209 FRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQ-------------------- 248
           F+ L NL+ L L    L +I     +GL +L+ L+   NQ                    
Sbjct: 193 FQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYL 252

Query: 249 ----LARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKF 304
               ++++P     Q+P L  L L  N L+ +  G F  M +L+EL L +   + S+   
Sbjct: 253 SNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYD-NHISSLPDN 311

Query: 305 ALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEV 364
              NL +L  L ++ N ++SFI P AF+ L ++  L L+ NAL  L       L NLQ +
Sbjct: 312 VFSNLRQLQVLILSRN-QISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNI 370

Query: 365 GLHGNPIR 372
            L  N +R
Sbjct: 371 SLQNNRLR 378



 Score =  125 bits (315), Expect = 1e-28
 Identities = 91/303 (30%), Positives = 138/303 (45%), Gaps = 2/303 (0%)

Query: 72  QTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTR 131
           ++LLL SN ++++  +     +NL EL L  N      D  F  L  L  L+L +N LT 
Sbjct: 128 ESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTH 187

Query: 132 LEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNL 191
           +    F  L +LQ L L  N+L  I    F GL NL  L L  N +  +    F    NL
Sbjct: 188 ISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNL 247

Query: 192 EILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLAR 251
           + L +  N +  +    F  L  L  L L G +L+E+S      + +L  L  YDN ++ 
Sbjct: 248 QRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISS 307

Query: 252 VPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPE 311
           +P      +  L+ L L++N +  + PG F  +  L+EL L+    L  +D      L  
Sbjct: 308 LPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHT-NALQDLDGNVFRMLAN 366

Query: 312 LTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPI 371
           L  + + NN RL  +    F ++  +  + L NN L  L     + L  L E+ L+ NP 
Sbjct: 367 LQNISLQNN-RLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPW 425

Query: 372 RCD 374
           RCD
Sbjct: 426 RCD 428



 Score = 98.2 bits (243), Expect = 2e-20
 Identities = 74/252 (29%), Positives = 117/252 (46%), Gaps = 1/252 (0%)

Query: 70  GTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQL 129
           G   L L  NS+  +      +L NL  L L +N  +D     F  L  L  L L++NQ+
Sbjct: 174 GLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQI 233

Query: 130 TRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLP 189
             L    F    +LQ LYL++N + ++ P  F  L  L RL L  N L+ +    F  +P
Sbjct: 234 GLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMP 293

Query: 190 NLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQL 249
           NL  L +  N + ++ D  F  L  L+ L+L+   +  IS  A  GL  L  LS + N L
Sbjct: 294 NLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNAL 353

Query: 250 ARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNL 309
             +       +  L+ + L  N L+++    FAN+  L  + L N  +L ++      +L
Sbjct: 354 QDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQN-NQLENLPLGIFDHL 412

Query: 310 PELTKLDITNNP 321
            +L +L + +NP
Sbjct: 413 GKLCELRLYDNP 424


>gi|31542244 leucine rich repeat and fibronectin type III domain
           containing 5 [Homo sapiens]
          Length = 719

 Score =  132 bits (332), Expect = 1e-30
 Identities = 109/393 (27%), Positives = 170/393 (43%), Gaps = 74/393 (18%)

Query: 120 LSLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRA 179
           + L L +N +T ++   FA + SL +L L+ N +  I P AF+ L NL  LHLNSN L  
Sbjct: 54  VELRLADNFVTNIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTK 113

Query: 180 IDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSL 239
           I +                       DM F  L+NL  L+L    L  IS  A + + +L
Sbjct: 114 ITN-----------------------DM-FSGLSNLHHLILNNNQLTLISSTAFDDVFAL 149

Query: 240 ESLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELV 299
           E L    N L  +P  A+E++  L  L L+ N +  +  G F+                 
Sbjct: 150 EELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIPKGTFS----------------- 192

Query: 300 SIDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLP 359
                   +L ++T+LD+T+N +L  + P     L Q   ++  +  +S          P
Sbjct: 193 --------HLHKMTRLDVTSN-KLQKLPP---DPLFQRAQVLATSGIIS----------P 230

Query: 360 NLQEVGLHGNPIRCDCVIRWANATGTRVRFIEPQSTLCAEPPDLQRLPVREVPFREMTDH 419
           +   +   GNP+ C+C + W           E     CA PP L       +P  E    
Sbjct: 231 STFALSFGGNPLHCNCELLWLRRLSR-----EDDLETCASPPLLTGRYFWSIPEEEFL-- 283

Query: 420 CLPLISPRSFPPSLQVASGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPE 479
           C P +  R     ++V  G+   L C+A  +PEP I+W++P G  ++ A    R  VY  
Sbjct: 284 CEPPLITR-HTHEMRVLEGQRATLRCKARGDPEPAIHWISPEGKLISNA---TRSLVYDN 339

Query: 480 GTLELRRVTAEEAGLYTCVAQNLVGADTKTVSV 512
           GTL++   T ++ G +TC+A N  G  T+ V +
Sbjct: 340 GTLDILITTVKDTGAFTCIASNPAGEATQIVDL 372



 Score = 84.7 bits (208), Expect = 3e-16
 Identities = 62/200 (31%), Positives = 94/200 (47%), Gaps = 9/200 (4%)

Query: 29  CPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQSE 88
           CP +C CQI        S   AT   C    L  VPP +   T  L L  N +  + + +
Sbjct: 20  CPKRCVCQIL-------SPNLATL--CAKKGLLFVPPNIDRRTVELRLADNFVTNIKRKD 70

Query: 89  LGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELYL 148
              + +L +L LS+N+ S      F  L  L +LHL  N+LT++ +  F+GL++L  L L
Sbjct: 71  FANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLSNLHHLIL 130

Query: 149 NHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMN 208
           N+NQL  I+  AF  +  L  L L+ N L  I     E + +L  L +  N +D I    
Sbjct: 131 NNNQLTLISSTAFDDVFALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIPKGT 190

Query: 209 FRPLANLRSLVLAGMNLREI 228
           F  L  +  L +    L+++
Sbjct: 191 FSHLHKMTRLDVTSNKLQKL 210


>gi|225579152 insulin-like growth factor binding protein, acid
           labile subunit isoform 1 precursor [Homo sapiens]
          Length = 643

 Score =  130 bits (326), Expect = 6e-30
 Identities = 112/377 (29%), Positives = 169/377 (44%), Gaps = 16/377 (4%)

Query: 3   LLVAPLLLAWVA-------GATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDC 55
           L +A LLL+WVA       GA    P       CP  C C             +  +V C
Sbjct: 46  LALALLLLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSY-------DDDADELSVFC 98

Query: 56  NDLFLTAVPPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHA 115
           +   LT +P  +P GTQ L L  N++  V  +    L++L  L+L               
Sbjct: 99  SSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLG 158

Query: 116 LPQLLSLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSN 175
           L  L  LHLE NQL  L   +FA   +L  L L++N+L R+    F GL +L  L+L  N
Sbjct: 159 LENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWN 218

Query: 176 LLRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEG 235
            L  +    F  L +L  L++ GN++  +    F  LA LR L L+   LR I       
Sbjct: 219 SLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQ 278

Query: 236 LQSLESLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNM 295
           L  L+ L    N +A V   A   +  L++LDL+ N +  +    F  +L L+ L L++ 
Sbjct: 279 LPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSH- 337

Query: 296 EELVSIDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTV 355
             + S+      +L  L +L + +N R+  +  R+F  L Q+E L L++N L  +     
Sbjct: 338 NAIASLRPRTFKDLHFLEELQLGHN-RIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAF 396

Query: 356 ESLPNLQEVGLHGNPIR 372
             L N+  + L GN +R
Sbjct: 397 LGLTNVAVMNLSGNCLR 413



 Score =  124 bits (311), Expect = 3e-28
 Identities = 104/360 (28%), Positives = 177/360 (49%), Gaps = 12/360 (3%)

Query: 74  LLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLE 133
           L+L  N +  +  +    LA L ELDLS+N+    +   F  LP+L  L+L+ N +  + 
Sbjct: 237 LVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVA 296

Query: 134 DHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEI 193
             +F GL +L+ L L+HN++  +    F GL  L  L L+ N + ++  R F+ L  LE 
Sbjct: 297 PGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEE 356

Query: 194 LMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARVP 253
           L +G N++  + + +F  L  L  L L    L+E+   A  GL ++  ++   N L  +P
Sbjct: 357 LQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLP 416

Query: 254 RRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELT 313
            +    +  L  L L  + L R+ P  F  +  L+ L L +   LV I++ +L  L EL 
Sbjct: 417 EQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKD-NGLVGIEEQSLWGLAELL 475

Query: 314 KLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRC 373
           +LD+T+N +L+ +  R F  L ++E L+L+ N L+ L    +  L     + +  N  R 
Sbjct: 476 ELDLTSN-QLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHN--RL 532

Query: 374 DCVIRWANATGTRVRFIEPQS----TLCAEPPDLQRLPVREVPFREMTDHCLPLISPRSF 429
           + +     A   R+R++  ++    T   +PP L+RL +   P+    D   PL + R F
Sbjct: 533 EALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPW----DCGCPLKALRDF 588



 Score =  113 bits (283), Expect = 5e-25
 Identities = 105/359 (29%), Positives = 157/359 (43%), Gaps = 25/359 (6%)

Query: 72  QTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTR 131
           Q L L  N I  V       L  L  LDLS N  +   +  F  L  L  L L  N +  
Sbjct: 283 QKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIAS 342

Query: 132 LEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNL 191
           L   +F  L  L+EL L HN++ ++A R+F GL  L  L L+ N L+ + +  F  L N+
Sbjct: 343 LRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNV 402

Query: 192 EILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLAR 251
            ++ + GN +  + +  FR L  L SL L G  L  I  +   GL  L  L   DN L  
Sbjct: 403 AVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVG 462

Query: 252 VPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPE 311
           +  ++L  +  L  LDL  N L  +    F  +  L+ L L +   L  +   AL  L  
Sbjct: 463 IEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYL-LLSRNRLAELPADALGPLQR 521

Query: 312 LTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPI 371
              LD+++N RL  +       L ++  L L NN+L     Q     P L+ + L GNP 
Sbjct: 522 AFWLDVSHN-RLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQP----PGLERLWLEGNPW 576

Query: 372 RCDCVIR----WANATGTRV-RFIEP--------------QSTLCAEPPDLQRLPVREV 411
            C C ++    +A    + V RF++                +  CA PP++  L +R++
Sbjct: 577 DCGCPLKALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASPPEVVGLDLRDL 635



 Score = 86.3 bits (212), Expect = 9e-17
 Identities = 76/262 (29%), Positives = 114/262 (43%), Gaps = 27/262 (10%)

Query: 60  LTAVPPALPAGTQTLL---LQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHAL 116
           + AV P    G + L    L  N +  + +     L  L  L LS N+ +  R   F  L
Sbjct: 292 IAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDL 351

Query: 117 PQLLSLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNL 176
             L  L L  N++ +L + SF GL  L+ L L+HNQL  +   AF GL+N+  ++L+ N 
Sbjct: 352 HFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNC 411

Query: 177 LRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYAL--- 233
           LR +  + F  L  L  L + G+ +  I    F  L+ LR L L    L  I + +L   
Sbjct: 412 LRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGL 471

Query: 234 ---------------------EGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDLNKNP 272
                                +GL  LE L    N+LA +P  AL  +    +LD++ N 
Sbjct: 472 AELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNR 531

Query: 273 LQRVGPGDFANMLHLKELGLNN 294
           L+ +     A +  L+ L L N
Sbjct: 532 LEALPNSLLAPLGRLRYLSLRN 553



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 41/134 (30%), Positives = 61/134 (45%), Gaps = 4/134 (2%)

Query: 69  AGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQ 128
           +G + L L+ N +V +++  L  LA L ELDL+ N  +      F  L +L  L L  N+
Sbjct: 448 SGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNR 507

Query: 129 LTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEML 188
           L  L   +   L     L ++HN+L  +     + L  L  L L +N LR    +     
Sbjct: 508 LAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQ----P 563

Query: 189 PNLEILMIGGNKVD 202
           P LE L + GN  D
Sbjct: 564 PGLERLWLEGNPWD 577


>gi|4826772 insulin-like growth factor binding protein, acid labile
           subunit isoform 2 precursor [Homo sapiens]
          Length = 605

 Score =  130 bits (326), Expect = 6e-30
 Identities = 112/377 (29%), Positives = 169/377 (44%), Gaps = 16/377 (4%)

Query: 3   LLVAPLLLAWVA-------GATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDC 55
           L +A LLL+WVA       GA    P       CP  C C             +  +V C
Sbjct: 8   LALALLLLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSY-------DDDADELSVFC 60

Query: 56  NDLFLTAVPPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHA 115
           +   LT +P  +P GTQ L L  N++  V  +    L++L  L+L               
Sbjct: 61  SSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLG 120

Query: 116 LPQLLSLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSN 175
           L  L  LHLE NQL  L   +FA   +L  L L++N+L R+    F GL +L  L+L  N
Sbjct: 121 LENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWN 180

Query: 176 LLRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEG 235
            L  +    F  L +L  L++ GN++  +    F  LA LR L L+   LR I       
Sbjct: 181 SLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQ 240

Query: 236 LQSLESLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNM 295
           L  L+ L    N +A V   A   +  L++LDL+ N +  +    F  +L L+ L L++ 
Sbjct: 241 LPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSH- 299

Query: 296 EELVSIDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTV 355
             + S+      +L  L +L + +N R+  +  R+F  L Q+E L L++N L  +     
Sbjct: 300 NAIASLRPRTFKDLHFLEELQLGHN-RIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAF 358

Query: 356 ESLPNLQEVGLHGNPIR 372
             L N+  + L GN +R
Sbjct: 359 LGLTNVAVMNLSGNCLR 375



 Score =  124 bits (311), Expect = 3e-28
 Identities = 104/360 (28%), Positives = 177/360 (49%), Gaps = 12/360 (3%)

Query: 74  LLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLE 133
           L+L  N +  +  +    LA L ELDLS+N+    +   F  LP+L  L+L+ N +  + 
Sbjct: 199 LVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVA 258

Query: 134 DHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEI 193
             +F GL +L+ L L+HN++  +    F GL  L  L L+ N + ++  R F+ L  LE 
Sbjct: 259 PGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEE 318

Query: 194 LMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARVP 253
           L +G N++  + + +F  L  L  L L    L+E+   A  GL ++  ++   N L  +P
Sbjct: 319 LQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLP 378

Query: 254 RRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELT 313
            +    +  L  L L  + L R+ P  F  +  L+ L L +   LV I++ +L  L EL 
Sbjct: 379 EQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKD-NGLVGIEEQSLWGLAELL 437

Query: 314 KLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRC 373
           +LD+T+N +L+ +  R F  L ++E L+L+ N L+ L    +  L     + +  N  R 
Sbjct: 438 ELDLTSN-QLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHN--RL 494

Query: 374 DCVIRWANATGTRVRFIEPQS----TLCAEPPDLQRLPVREVPFREMTDHCLPLISPRSF 429
           + +     A   R+R++  ++    T   +PP L+RL +   P+    D   PL + R F
Sbjct: 495 EALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPW----DCGCPLKALRDF 550



 Score =  113 bits (283), Expect = 5e-25
 Identities = 105/359 (29%), Positives = 157/359 (43%), Gaps = 25/359 (6%)

Query: 72  QTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTR 131
           Q L L  N I  V       L  L  LDLS N  +   +  F  L  L  L L  N +  
Sbjct: 245 QKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIAS 304

Query: 132 LEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNL 191
           L   +F  L  L+EL L HN++ ++A R+F GL  L  L L+ N L+ + +  F  L N+
Sbjct: 305 LRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNV 364

Query: 192 EILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLAR 251
            ++ + GN +  + +  FR L  L SL L G  L  I  +   GL  L  L   DN L  
Sbjct: 365 AVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVG 424

Query: 252 VPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPE 311
           +  ++L  +  L  LDL  N L  +    F  +  L+ L L +   L  +   AL  L  
Sbjct: 425 IEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYL-LLSRNRLAELPADALGPLQR 483

Query: 312 LTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPI 371
              LD+++N RL  +       L ++  L L NN+L     Q     P L+ + L GNP 
Sbjct: 484 AFWLDVSHN-RLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQP----PGLERLWLEGNPW 538

Query: 372 RCDCVIR----WANATGTRV-RFIEP--------------QSTLCAEPPDLQRLPVREV 411
            C C ++    +A    + V RF++                +  CA PP++  L +R++
Sbjct: 539 DCGCPLKALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASPPEVVGLDLRDL 597



 Score = 86.3 bits (212), Expect = 9e-17
 Identities = 76/262 (29%), Positives = 114/262 (43%), Gaps = 27/262 (10%)

Query: 60  LTAVPPALPAGTQTLL---LQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHAL 116
           + AV P    G + L    L  N +  + +     L  L  L LS N+ +  R   F  L
Sbjct: 254 IAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDL 313

Query: 117 PQLLSLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNL 176
             L  L L  N++ +L + SF GL  L+ L L+HNQL  +   AF GL+N+  ++L+ N 
Sbjct: 314 HFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNC 373

Query: 177 LRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYAL--- 233
           LR +  + F  L  L  L + G+ +  I    F  L+ LR L L    L  I + +L   
Sbjct: 374 LRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGL 433

Query: 234 ---------------------EGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDLNKNP 272
                                +GL  LE L    N+LA +P  AL  +    +LD++ N 
Sbjct: 434 AELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNR 493

Query: 273 LQRVGPGDFANMLHLKELGLNN 294
           L+ +     A +  L+ L L N
Sbjct: 494 LEALPNSLLAPLGRLRYLSLRN 515



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 41/134 (30%), Positives = 61/134 (45%), Gaps = 4/134 (2%)

Query: 69  AGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQ 128
           +G + L L+ N +V +++  L  LA L ELDL+ N  +      F  L +L  L L  N+
Sbjct: 410 SGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNR 469

Query: 129 LTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEML 188
           L  L   +   L     L ++HN+L  +     + L  L  L L +N LR    +     
Sbjct: 470 LAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQ----P 525

Query: 189 PNLEILMIGGNKVD 202
           P LE L + GN  D
Sbjct: 526 PGLERLWLEGNPWD 539


>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
          Length = 545

 Score =  128 bits (322), Expect = 2e-29
 Identities = 111/429 (25%), Positives = 177/429 (41%), Gaps = 70/429 (16%)

Query: 28  PCPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQS 87
           PCP  C C ++              V C+D  L  VP  +P  T+ ++    S   ++  
Sbjct: 21  PCPMGCDCFVQE-------------VFCSDEELATVPLDIPPYTKNIIFVETSFTTLETR 67

Query: 88  ELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELY 147
             G   NLT++          R   F  LP+L  L +  +    L  + F+ L SL +L 
Sbjct: 68  AFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLT 127

Query: 148 LNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDM 207
           LN N L  +    F  L+ L  LHL  N L+A+  R F+ L +L+ L +  N +  + + 
Sbjct: 128 LNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEE 187

Query: 208 NFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARVPRRALEQV------- 260
            F PL +L++L L+   L  +       L SL+ L    N ++ +P +   Q+       
Sbjct: 188 LFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLW 247

Query: 261 -----------------------------------------PGLKFLDLNKNPLQRVGPG 279
                                                    P L  L L  N L+ V  G
Sbjct: 248 LQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEG 307

Query: 280 DFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMET 339
            FA++ +L+ L L+    +  +      +L EL KL + +N  L+ +HP  F +L ++E 
Sbjct: 308 TFAHLSNLRSLMLS-YNAITHLPAGIFRDLEELVKLYLGSN-NLTALHPALFQNLSKLEL 365

Query: 340 LMLNNNALSALHQQTVESLPNLQEVGLHGNPIRCDC----VIRWANATGTRVRFIEPQST 395
           L L+ N L+ L +   ++  NL  + LHGNP +CDC    +  W      R+  I+   T
Sbjct: 366 LSLSKNQLTTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQYTDRLLNIQ---T 422

Query: 396 LCAEPPDLQ 404
            CA P  L+
Sbjct: 423 YCAGPAYLK 431


>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
           [Homo sapiens]
          Length = 1093

 Score =  128 bits (322), Expect = 2e-29
 Identities = 145/588 (24%), Positives = 234/588 (39%), Gaps = 105/588 (17%)

Query: 3   LLVAPLLLAWVAGATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFLTA 62
           LL+  LLL  +   TAA        PC   C C                ++DC    L A
Sbjct: 18  LLLLWLLLLRLEPVTAAAGP---RAPCAAACTCA-------------GDSLDCGGRGLAA 61

Query: 63  VPPALPAGTQ-----------------------------------------------TLL 75
           +P  LP+ T+                                               +L 
Sbjct: 62  LPGDLPSWTRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAASSHVVSLF 121

Query: 76  LQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDH 135
           LQ N I  V+ S+L    +L  LDLS N+ ++ R+  F   P +  L+L  N++  LE  
Sbjct: 122 LQHNKIRSVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELG 181

Query: 136 SFAGLA-SLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEIL 194
           +F GL+ SL  L L+ N++ ++  RAF  L  L +L LN N +R I+   F+ L +LE+L
Sbjct: 182 AFDGLSRSLLTLRLSKNRITQLPVRAFK-LPRLTQLDLNRNRIRLIEGLTFQGLNSLEVL 240

Query: 195 MIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARVPR 254
            +  N +  + D  F  L+ +  L L   +L E++  +L GL +L  L   +N +AR+ R
Sbjct: 241 KLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHR 300

Query: 255 R------------------------ALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKEL 290
           +                        +L ++  L  L L+ N +  +  G F  +  L+ L
Sbjct: 301 KGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVL 360

Query: 291 GLNNMEELVSID--KFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALS 348
            L++ E   +I+    A   L  L+KL +  N ++  +  RAF  L  +E L L  NA+ 
Sbjct: 361 DLDHNEISGTIEDTSGAFSGLDSLSKLTLFGN-KIKSVAKRAFSGLEGLEHLNLGGNAIR 419

Query: 349 ALHQQTVESLPNLQEVGLHGNPIRCDCVIRWANATGTRVRFIEPQSTLCAEPPDLQRLPV 408
           ++       + NL+E+ +  +   CDC ++W              +  CA P  L+   +
Sbjct: 420 SVQFDAFVKMKNLKELHISSDSFLCDCQLKWLPPWLIGRMLQAFVTATCAHPESLKGQSI 479

Query: 409 REVPFREMTDHCLPLISPR--SFPPSLQVASGESMVLHCRAL-AEPEPEIYWVTPAGLRL 465
             VP       C   + P+  + P +     G+ +   C A  +   P  +        L
Sbjct: 480 FSVPPESFV--CDDFLKPQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVL 537

Query: 466 TPAHAGRRYRVYPEG--------TLELRRVTAEEAGLYTCVAQNLVGA 505
           T A       V+ +          L LR+VT    G Y CV  N  G+
Sbjct: 538 TNADMENFVHVHAQDGEVMEYTTILHLRQVTFGHEGRYQCVITNHFGS 585



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 26/73 (35%), Positives = 38/73 (52%), Gaps = 5/73 (6%)

Query: 435 VASGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEG-TLELRRVTAEEAG 493
           V+ GE++ L C+A   P P I W    G R  P     R+ + P+   L ++ V AE+AG
Sbjct: 704 VSVGETVALQCKATGNPPPRITWF--KGDR--PLSLTERHHLTPDNQLLVVQNVVAEDAG 759

Query: 494 LYTCVAQNLVGAD 506
            YTC   N +G +
Sbjct: 760 RYTCEMSNTLGTE 772



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 25/86 (29%), Positives = 40/86 (46%), Gaps = 2/86 (2%)

Query: 430 PPSLQVASGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEGTLE-LRRVT 488
           P  + + +     L C A   P P+I W    G    PA   RR  V P+  +  +  V 
Sbjct: 605 PHDITIRTTTMARLECAATGHPNPQIAWQKDGGTDF-PAARERRMHVMPDDDVFFITDVK 663

Query: 489 AEEAGLYTCVAQNLVGADTKTVSVVV 514
            ++AG+Y+C AQN  G+ +   ++ V
Sbjct: 664 IDDAGVYSCTAQNSAGSISANATLTV 689


>gi|198041768 synleurin [Homo sapiens]
          Length = 622

 Score =  128 bits (321), Expect = 2e-29
 Identities = 106/364 (29%), Positives = 174/364 (47%), Gaps = 13/364 (3%)

Query: 53  VDCNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCD 112
           ++C +L L+++P   P  T  L L  N+I  +++SEL  L +L  L L  ++        
Sbjct: 44  INCRNLGLSSIPKNFPESTVFLYLTGNNISYINESELTGLHSLVALYLDNSNILYVYPKA 103

Query: 113 FHALPQLLSLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHL 172
           F  L  L  L L  N + RL+   F GL +L+ LYL +NQ+  +    F+ L ++  L+L
Sbjct: 104 FVQLRHLYFLFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNL 163

Query: 173 NSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYA 232
             N L  + S  F  +  L IL +  N +  I +  F+ L NL  L L   NL ++   A
Sbjct: 164 QRNRLTVLGSGTFVGMVALRILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNA 223

Query: 233 LEGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGL 292
            E L+SL  LS   N +  +   A + +  L++L L  + ++ V    F+ + +LK L L
Sbjct: 224 FEVLKSLRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLIL 283

Query: 293 --NNMEELVSIDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSAL 350
             N++E L S D F+L  L  L  L +  N  +S  +    +    ++ L L+ N L+AL
Sbjct: 284 SHNDLENLNS-DTFSL--LKNLIYLKLDRNRIISIDNDTFENMGASLKILNLSFNNLTAL 340

Query: 351 HQQTVESLPNLQEVGLHGNPIRCDCVIRWANATGTRVRFIEPQSTL---CAEPPDLQRLP 407
           H + ++ L +L  +  + NP  C+C +      G R        TL   C  PP ++   
Sbjct: 341 HPRVLKPLSSLIHLQANSNPWECNCKL-----LGLRDWLASSAITLNIYCQNPPSMRGRA 395

Query: 408 VREV 411
           +R +
Sbjct: 396 LRYI 399


>gi|27363458 leucine rich repeat and fibronectin type III domain
           containing 4 [Homo sapiens]
          Length = 635

 Score =  126 bits (317), Expect = 6e-29
 Identities = 148/557 (26%), Positives = 224/557 (40%), Gaps = 93/557 (16%)

Query: 145 ELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAI 204
           EL L  N +  + P  F  ++ L+ L L+ N +  I +R F  L +L  L + GN++  +
Sbjct: 52  ELRLADNFIQALGPPDFRNMTGLVDLTLSRNAITRIGARAFGDLESLRSLHLDGNRLVEL 111

Query: 205 LDMNFRPLANLRSLVLAGMNLREISDYALEG-LQSLESLSFYDNQLARVPRRALEQVPGL 263
              + R   NL+ L+L+G  L  I+  A +  L+SLE L    N L +VP   +  +P L
Sbjct: 112 GTGSLRGPVNLQHLILSGNQLGRIAPGAFDDFLESLEDLDLSYNNLRQVPWAGIGAMPAL 171

Query: 264 KFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNPRL 323
             L+L+ N +  + PG FA                          L +L++LD+T+N RL
Sbjct: 172 HTLNLDHNLIDALPPGAFA-------------------------QLGQLSRLDLTSN-RL 205

Query: 324 SFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRCDCVIRWANAT 383
           + + P                        +  E+ P    +   GNP+ C+C + W    
Sbjct: 206 ATLAPDPLFS-----------------RGRDAEASPAPLVLSFSGNPLHCNCELLWLR-- 246

Query: 384 GTRVRFIEPQS-TLCAEPPDLQRLPVREVPFREMTDHCLPLISPRSFPPSLQVASGESMV 442
               R   P     CA PP L       VP  E +  C P +  R     L V  G+   
Sbjct: 247 ----RLARPDDLETCASPPGLAGRYFWAVPEGEFS--CEPPLIAR-HTQRLWVLEGQRAT 299

Query: 443 LHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEGTLELRRVTAEEAGLYTCVAQNL 502
           L CRAL +P P ++WV P   RL    +  R R +P GTLE+    A +AG YTC+A N 
Sbjct: 300 LRCRALGDPAPTMHWVGPDD-RLVGNSS--RARAFPNGTLEIGVTGAGDAGGYTCIATNP 356

Query: 503 VGADTKTVSVVV------GRALLQPGRD-------------EGQGL-----ELRVQETHP 538
            G  T  V + V      G +  + GR              EG+G       ++V E   
Sbjct: 357 AGEATARVELRVLALPHGGNSSAEGGRPGPSDIAASARTAAEGEGTLESEPAVQVTEVTA 416

Query: 539 YHILLSWVTPPNTVSTNLTWSSASSLRGQGATALARL-PRGTHSYNITRLLQATEYWACL 597
              L+SW   P   +  +          +  T + R+ P  +H + +  L+   +Y  CL
Sbjct: 417 TSGLVSW--GPGRPADPVWMFQIQYNSSEDETLIYRIVPASSHHFLLKHLVPGADYDLCL 474

Query: 598 QV-------AFADAHTQLACVWARTKEATS-CHRALGDRPGLIAILALAVLLLAAGLAAH 649
                    +   A   L C    T  A+  CH       G    +A+  +L+AA L   
Sbjct: 475 LALSPAAGPSDLTATRLLGCAHFSTLPASPLCHALQAHVLGGTLTVAVGGVLVAALLVFT 534

Query: 650 LGTGQPRKGVG-GRRPL 665
           +      +G G GR PL
Sbjct: 535 VALLVRGRGAGNGRLPL 551



 Score = 83.2 bits (204), Expect = 8e-16
 Identities = 72/227 (31%), Positives = 98/227 (43%), Gaps = 19/227 (8%)

Query: 4   LVAPLLLAWVAGATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAV 63
           +  PLLL  +A   AA         CP  C CQ         +  E+ +  C    L  V
Sbjct: 1   MAPPLLLLLLASGAAA---------CPLPCVCQ---------NLSESLSTLCAHRGLLFV 42

Query: 64  PPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLH 123
           PP +   T  L L  N I  +   +   +  L +L LS+N+ +      F  L  L SLH
Sbjct: 43  PPNVDRRTVELRLADNFIQALGPPDFRNMTGLVDLTLSRNAITRIGARAFGDLESLRSLH 102

Query: 124 LEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSG-LSNLLRLHLNSNLLRAIDS 182
           L+ N+L  L   S  G  +LQ L L+ NQL RIAP AF   L +L  L L+ N LR +  
Sbjct: 103 LDGNRLVELGTGSLRGPVNLQHLILSGNQLGRIAPGAFDDFLESLEDLDLSYNNLRQVPW 162

Query: 183 RWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREIS 229
                +P L  L +  N +DA+    F  L  L  L L    L  ++
Sbjct: 163 AGIGAMPALHTLNLDHNLIDALPPGAFAQLGQLSRLDLTSNRLATLA 209



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 30/92 (32%), Positives = 45/92 (48%), Gaps = 1/92 (1%)

Query: 68  PAGTQTLLLQSNSIVRVDQSELG-YLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEE 126
           P   Q L+L  N + R+       +L +L +LDLS N+          A+P L +L+L+ 
Sbjct: 119 PVNLQHLILSGNQLGRIAPGAFDDFLESLEDLDLSYNNLRQVPWAGIGAMPALHTLNLDH 178

Query: 127 NQLTRLEDHSFAGLASLQELYLNHNQLYRIAP 158
           N +  L   +FA L  L  L L  N+L  +AP
Sbjct: 179 NLIDALPPGAFAQLGQLSRLDLTSNRLATLAP 210


>gi|13375646 leucine rich repeat and fibronectin type III domain
           containing 3 [Homo sapiens]
          Length = 628

 Score =  124 bits (312), Expect = 2e-28
 Identities = 109/373 (29%), Positives = 162/373 (43%), Gaps = 53/373 (14%)

Query: 145 ELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAI 204
           EL L  N +  +  R  + ++ LL L L+ N +R + +  F  L  L  L + GN++ ++
Sbjct: 63  ELRLADNFIASVRRRDLANMTGLLHLSLSRNTIRHVAAGAFADLRALRALHLDGNRLTSL 122

Query: 205 LDMNFRPLANLRSLVLAGMNLREISDYALEGL-QSLESLSFYDNQLARVPRRALEQVPGL 263
            +   R L NLR L+L+   L  ++  AL+   ++LE L    N L ++P  AL ++  +
Sbjct: 123 GEGQLRGLVNLRHLILSNNQLAALAAGALDDCAETLEDLDLSYNNLEQLPWEALGRLGNV 182

Query: 264 KFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNPRL 323
             L L+ N L  V  G F+                          L +L +LD+T+N RL
Sbjct: 183 NTLGLDHNLLASVPAGAFSR-------------------------LHKLARLDMTSN-RL 216

Query: 324 SFIHPRA-FHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRCDCVIRWANA 382
           + I P   F  LP +       +  SAL             +   GNP+ C+C + W   
Sbjct: 217 TTIPPDPLFSRLPLLARP--RGSPASAL------------VLAFGGNPLHCNCELVWLRR 262

Query: 383 TGTRVRFIEPQSTLCAEPPDLQRLPVREVPFREMTDHCLPLISPRSFPPSLQVASGESMV 442
                   E     CA PP L       V   E    C P +     PP L V +G    
Sbjct: 263 LAR-----EDDLEACASPPALGGRYFWAVGEEEFV--CEPPVVTHRSPP-LAVPAGRPAA 314

Query: 443 LHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEGTLELRRVTAEEAGLYTCVAQNL 502
           L CRA+ +PEP + WV+P G  L  +    R R +P GTLEL      + G++TC+A N 
Sbjct: 315 LRCRAVGDPEPRVRWVSPQGRLLGNSS---RARAFPNGTLELLVTEPGDGGIFTCIAANA 371

Query: 503 VGADTKTVSVVVG 515
            G  T  V + VG
Sbjct: 372 AGEATAAVELTVG 384



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 67/230 (29%), Positives = 98/230 (42%), Gaps = 15/230 (6%)

Query: 3   LLVAPLLLAWVAGATAAVP---VVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLF 59
           + + PLLL  +  A A+ P     P   PCP +C CQ +             +V C    
Sbjct: 1   MAILPLLLCLLPLAPASSPPQSATP--SPCPRRCRCQTQSL---------PLSVLCPGAG 49

Query: 60  LTAVPPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQL 119
           L  VPP+L      L L  N I  V + +L  +  L  L LS+N+        F  L  L
Sbjct: 50  LLFVPPSLDRRAAELRLADNFIASVRRRDLANMTGLLHLSLSRNTIRHVAAGAFADLRAL 109

Query: 120 LSLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLR-LHLNSNLLR 178
            +LHL+ N+LT L +    GL +L+ L L++NQL  +A  A    +  L  L L+ N L 
Sbjct: 110 RALHLDGNRLTSLGEGQLRGLVNLRHLILSNNQLAALAAGALDDCAETLEDLDLSYNNLE 169

Query: 179 AIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREI 228
            +       L N+  L +  N + ++    F  L  L  L +    L  I
Sbjct: 170 QLPWEALGRLGNVNTLGLDHNLLASVPAGAFSRLHKLARLDMTSNRLTTI 219


>gi|4504379 leucine-rich repeat-containing G protein-coupled
           receptor 5 [Homo sapiens]
          Length = 907

 Score =  124 bits (311), Expect = 3e-28
 Identities = 114/390 (29%), Positives = 168/390 (43%), Gaps = 59/390 (15%)

Query: 3   LLVAPLLLAWVAGATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFLTA 62
           LL  P+LL    G ++    V     CP  C C+           R    VDC+DL L+ 
Sbjct: 9   LLSLPVLLQLATGGSSPRSGVLLR-GCPTHCHCE--------PDGRMLLRVDCSDLGLSE 59

Query: 63  VPPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSL 122
           +P  L   T  L L  N+I ++  + L  L  L EL L+ N+ +      F  L  L  L
Sbjct: 60  LPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVL 119

Query: 123 HLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDS 182
            L+ NQL  +   +   L SLQ L L+ N +  + P  FSGL +L  L L+ N L  I  
Sbjct: 120 MLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPV 179

Query: 183 RWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESL 242
           +                         FR L+ L+++ LA   +  I DYA   L SL  L
Sbjct: 180 Q------------------------AFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVL 215

Query: 243 SFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSID 302
             ++N++  + ++  + +  L+ LDLN N L    P     + +LKELG ++   + SI 
Sbjct: 216 HLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEF-PTAIRTLSNLKELGFHS-NNIRSIP 273

Query: 303 KFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNA---------------- 346
           + A V  P L  +   +NP + F+   AF HLP++ TL LN  +                
Sbjct: 274 EKAFVGNPSLITIHFYDNP-IQFVGRSAFQHLPELRTLTLNGASQITEFPDLTGTANLES 332

Query: 347 -------LSALHQQTVESLPNLQEVGLHGN 369
                  +S+L Q     LPNLQ + L  N
Sbjct: 333 LTLTGAQISSLPQTVCNQLPNLQVLDLSYN 362



 Score =  115 bits (287), Expect = 2e-25
 Identities = 95/312 (30%), Positives = 153/312 (49%), Gaps = 11/312 (3%)

Query: 60  LTAVPPALPAGTQTLL---LQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHAL 116
           ++ VPP+  +G  +L    L  N++  +       L+ L  + L+ N      D  F  L
Sbjct: 150 ISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNL 209

Query: 117 PQLLSLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNL 176
             L+ LHL  N++  L    F GL SL+ L LN+N L    P A   LSNL  L  +SN 
Sbjct: 210 SSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEF-PTAIRTLSNLKELGFHSNN 268

Query: 177 LRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYA-LEG 235
           +R+I  + F   P+L  +    N +  +    F+ L  LR+L L G +  +I+++  L G
Sbjct: 269 IRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGAS--QITEFPDLTG 326

Query: 236 LQSLESLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNM 295
             +LESL+    Q++ +P+    Q+P L+ LDL+ N L+ +        L   +L  N +
Sbjct: 327 TANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHNEI 386

Query: 296 EELVSIDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTV 355
            E + +D F    L  L  L++  N +++ IHP AF  LP +  L L++N LS+     +
Sbjct: 387 YE-IKVDTFQ--QLLSLRSLNLAWN-KIAIIHPNAFSTLPSLIKLDLSSNLLSSFPITGL 442

Query: 356 ESLPNLQEVGLH 367
             L +L+  G H
Sbjct: 443 HGLTHLKLTGNH 454



 Score = 76.6 bits (187), Expect = 7e-14
 Identities = 61/194 (31%), Positives = 95/194 (48%), Gaps = 10/194 (5%)

Query: 186 EMLPN-------LEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQS 238
           ++LPN       LE L + GN +  I    F  L +L+ L+L    LR +   AL+ L+S
Sbjct: 80  QLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRS 139

Query: 239 LESLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEEL 298
           L+SL    N ++ VP      +  L+ L L+ N L  +    F ++  L+ + L  + ++
Sbjct: 140 LQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLA-LNKI 198

Query: 299 VSIDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESL 358
             I  +A  NL  L  L + NN R+  +  + F  L  +ETL LN N L       + +L
Sbjct: 199 HHIPDYAFGNLSSLVVLHLHNN-RIHSLGKKCFDGLHSLETLDLNYNNLDEF-PTAIRTL 256

Query: 359 PNLQEVGLHGNPIR 372
            NL+E+G H N IR
Sbjct: 257 SNLKELGFHSNNIR 270



 Score = 73.9 bits (180), Expect = 5e-13
 Identities = 69/271 (25%), Positives = 116/271 (42%), Gaps = 32/271 (11%)

Query: 107 DARDCDFHALPQLLS-----LHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAF 161
           D  D     LP  LS     L L  N +++L  +    L  L+EL L  N L  I   AF
Sbjct: 51  DCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAF 110

Query: 162 SGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLA 221
           +GL +L  L L +N LR + +   + L +L+ L +  N +  +    F  L +LR L L 
Sbjct: 111 TGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLD 170

Query: 222 GMNLREISDYALEGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDF 281
              L EI   A   L +L++++   N++  +P  A   +  L  L L+ N +  +G   F
Sbjct: 171 DNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCF 230

Query: 282 ANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLM 341
             +  L+ L LN      ++D+F                       P A   L  ++ L 
Sbjct: 231 DGLHSLETLDLNYN----NLDEF-----------------------PTAIRTLSNLKELG 263

Query: 342 LNNNALSALHQQTVESLPNLQEVGLHGNPIR 372
            ++N + ++ ++     P+L  +  + NPI+
Sbjct: 264 FHSNNIRSIPEKAFVGNPSLITIHFYDNPIQ 294


>gi|149773484 leucine rich repeat and fibronectin type III domain
           containing 1 [Homo sapiens]
          Length = 771

 Score =  124 bits (310), Expect = 4e-28
 Identities = 108/398 (27%), Positives = 159/398 (39%), Gaps = 77/398 (19%)

Query: 118 QLLSLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLL 177
           +++ L L +N +  +    FA + SL  L L+ N + ++A  AF+ L  L  LHL+SN L
Sbjct: 66  RVVELRLTDNFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRL 125

Query: 178 RAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEG-L 236
             +                             R L NLR L+L    +R +   A +  L
Sbjct: 126 AEVRGD------------------------QLRGLGNLRHLILGNNQIRRVESAAFDAFL 161

Query: 237 QSLESLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNME 296
            ++E L    N L  +P  A+ Q+  L  L L+ N +  +  G F               
Sbjct: 162 STVEDLDLSYNNLEALPWEAVGQMVNLNTLTLDHNLIDHIAEGTF--------------- 206

Query: 297 ELVSIDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVE 356
                     V L +L +LD+T+N           H LP         + L    Q T  
Sbjct: 207 ----------VQLHKLVRLDMTSN---------RLHKLPP--------DGLFLRSQGTGP 239

Query: 357 SLPNLQEVGLHGNPIRCDCVIRWANATGTRVRFIEPQSTLCAEPPDLQRLPVREVPFREM 416
             P    V   GNP+ C+C + W     TR    E     CA P  L       +P  E 
Sbjct: 240 KPPTPLTVSFGGNPLHCNCELLWLRRL-TR----EDDLETCATPEHLTDRYFWSIPEEEF 294

Query: 417 TDHCLPLISPRSFPPSLQVASGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRV 476
              C P +  R       V  G+++ L CRA+ +PEP ++WV P G  L  +    R RV
Sbjct: 295 L--CEPPLITRQAGGRALVVEGQAVSLRCRAVGDPEPVVHWVAPDGRLLGNS---SRTRV 349

Query: 477 YPEGTLELRRVTAEEAGLYTCVAQNLVGADTKTVSVVV 514
             +GTL++   T  ++G +TC+A N  G  T  V V V
Sbjct: 350 RGDGTLDVTITTLRDSGTFTCIASNAAGEATAPVEVCV 387



 Score = 81.3 bits (199), Expect = 3e-15
 Identities = 66/222 (29%), Positives = 96/222 (43%), Gaps = 18/222 (8%)

Query: 8   LLLAWVAGATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPAL 67
           LLL W AGA+   P       CP +C CQ         +     T+ C    L  VPPA+
Sbjct: 21  LLLLW-AGASRGQP-------CPGRCICQ---------NVAPTLTMLCAKTGLLFVPPAI 63

Query: 68  PAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEEN 127
                 L L  N I  V + +   + +L  L LS+N+        F  L  L +LHL+ N
Sbjct: 64  DRRVVELRLTDNFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSN 123

Query: 128 QLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSG-LSNLLRLHLNSNLLRAIDSRWFE 186
           +L  +      GL +L+ L L +NQ+ R+   AF   LS +  L L+ N L A+      
Sbjct: 124 RLAEVRGDQLRGLGNLRHLILGNNQIRRVESAAFDAFLSTVEDLDLSYNNLEALPWEAVG 183

Query: 187 MLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREI 228
            + NL  L +  N +D I +  F  L  L  L +    L ++
Sbjct: 184 QMVNLNTLTLDHNLIDHIAEGTFVQLHKLVRLDMTSNRLHKL 225


>gi|51317373 netrin-G1 ligand [Homo sapiens]
          Length = 640

 Score =  123 bits (308), Expect = 7e-28
 Identities = 114/438 (26%), Positives = 185/438 (42%), Gaps = 78/438 (17%)

Query: 190 NLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQL 249
           N  +L +  N++  I   +F+ L +L  L L+  ++R I   A  GL +L +L  +DN+L
Sbjct: 77  NTRLLNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRL 136

Query: 250 ARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDK------ 303
             +P  A   +  LK L L  NP++ +    F  +  L+ L L  ++ L  I +      
Sbjct: 137 TTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGL 196

Query: 304 -------FALVNLPE---------LTKLDITNNPRLSFIHP------------------- 328
                   A+ NL E         L +LD++ N  LS I P                   
Sbjct: 197 SNLRYLNLAMCNLREIPNLTPLIKLDELDLSGN-HLSAIRPGSFQGLMHLQKLWMIQSQI 255

Query: 329 -----RAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRCDCVIRWANAT 383
                 AF +L  +  + L +N L+ L       L +L+ + LH NP  C+C I W +  
Sbjct: 256 QVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHNPWNCNCDILWLS-- 313

Query: 384 GTRVRFIEPQSTLCA----EPPDLQRLPVREVPFREMTDHCLPLISPRSFPPSLQVASGE 439
              ++ + P +T C      PP+L+   + E+     T +   ++ P   P  L V  G 
Sbjct: 314 -WWIKDMAPSNTACCARCNTPPNLKGRYIGELDQNYFTCYAPVIVEP---PADLNVTEGM 369

Query: 440 SMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEGTLELRRVTAEEAGLYTCVA 499
           +  L CRA +     + W+TP G  +T      R  V  +GTL    VT ++ G+YTC+ 
Sbjct: 370 AAELKCRA-STSLTSVSWITPNGTVMTHGAYKVRIAVLSDGTLNFTNVTVQDTGMYTCMV 428

Query: 500 QNLVGADTKTVSVVVGRA--------------LLQPGRDEGQGLELRVQETHPYHILLSW 545
            N VG  T + ++ V  A               ++P +DE +  +  V  T     ++ W
Sbjct: 429 SNSVGNTTASATLNVTAATTTPFSYFSTVTVETMEPSQDEARTTDNNVGPTP----VVDW 484

Query: 546 VTPPNTVSTNLTWSSASS 563
            T    V+T+LT  S  S
Sbjct: 485 ET--TNVTTSLTPQSTRS 500



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 82/294 (27%), Positives = 130/294 (44%), Gaps = 14/294 (4%)

Query: 2   RLLVAPLLLAWVAGATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFLT 61
           R L  PLL+  +A     V  +     CP  C+C             + + V C    L 
Sbjct: 20  RALFDPLLVVLLALQLLVVAGLVRAQTCPSVCSCS-----------NQFSKVICVRKNLR 68

Query: 62  AVPPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLS 121
            VP  +   T+ L L  N I  +  +   +L +L  L LS+N         F+ L  L +
Sbjct: 69  EVPDGISTNTRLLNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNT 128

Query: 122 LHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNS-NLLRAI 180
           L L +N+LT + + +F  L+ L+EL+L +N +  I   AF+ + +L RL L     L  I
Sbjct: 129 LELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYI 188

Query: 181 DSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLE 240
               FE L NL  L +    +  I   N  PL  L  L L+G +L  I   + +GL  L+
Sbjct: 189 SEGAFEGLSNLRYLNLAMCNLREI--PNLTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQ 246

Query: 241 SLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNN 294
            L    +Q+  + R A + +  L  ++L  N L  +    F  + HL+ + L++
Sbjct: 247 KLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHH 300



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 32/84 (38%), Positives = 45/84 (53%)

Query: 92  LANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELYLNHN 151
           L  L ELDLS N  S  R   F  L  L  L + ++Q+  +E ++F  L SL E+ L HN
Sbjct: 218 LIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHN 277

Query: 152 QLYRIAPRAFSGLSNLLRLHLNSN 175
            L  +    F+ L +L R+HL+ N
Sbjct: 278 NLTLLPHDLFTPLHHLERIHLHHN 301


>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
           isoform 2 [Homo sapiens]
          Length = 1119

 Score =  122 bits (305), Expect = 2e-27
 Identities = 138/491 (28%), Positives = 200/491 (40%), Gaps = 42/491 (8%)

Query: 53  VDCNDLFLTAVPPALPAGTQTLLLQ--SNSIVRVDQSELGYLANLTELDLSQNSFSDARD 110
           V  N+  L  +P   P      LL    N IV +    L    +L  LDLS N+ S+ + 
Sbjct: 103 VKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQT 162

Query: 111 CDFHALPQLLSLHLEENQLTRLEDHSFAGLAS-LQELYLNHNQLYRIAPRAFSGLSNLLR 169
             F AL QL  L+L  N++T +E   F  LA+ L  L LN N++  I P+ F  L  L  
Sbjct: 163 A-FPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFK-LPQLQH 219

Query: 170 LHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREIS 229
           L LN N ++ +D   F+ L  L+ L +  N V  ++D  F  L+N+  L L   NL EI+
Sbjct: 220 LELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEIT 279

Query: 230 DYALEGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDF-----ANM 284
              L GL  L+ L    N + R+   A E    L  LDL  N L R+    F      N 
Sbjct: 280 KGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNT 339

Query: 285 LH-------------------LKELGLNNMEELVSIDKF--ALVNLPELTKLDITNNPRL 323
           LH                   LK L L N E   +I+    A   L +L +L +  N R+
Sbjct: 340 LHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGN-RI 398

Query: 324 SFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRCDCVIRWANAT 383
             I  +AF  L  +E L L++NA+ +L       +  LQ++ L+ + + CDC ++W    
Sbjct: 399 RSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQW 458

Query: 384 GTRVRFIEPQSTLCAEPPDLQRLPVREVPFREMTDHCLPLISPRSFPPSLQVASGESMVL 443
                F    +  CA P  L+   +  V          P       P +     G ++  
Sbjct: 459 VAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSNLSF 518

Query: 444 HCRALAEPEPEIYWVTPAGLRL-------TPAHAGRRYRVYPEGT--LELRRVTAEEAGL 494
            C A +  +  + +       L         AH   +     E T  L LR V     G 
Sbjct: 519 ICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGK 578

Query: 495 YTCVAQNLVGA 505
           Y CV  N  G+
Sbjct: 579 YQCVISNHFGS 589



 Score =  115 bits (288), Expect = 1e-25
 Identities = 137/510 (26%), Positives = 200/510 (39%), Gaps = 75/510 (14%)

Query: 60  LTAVPPA---LPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHAL 116
           ++A+PP    LP   Q L L  N I  VD      L  L  L + +N  +   D  F  L
Sbjct: 204 ISAIPPKMFKLPQ-LQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGL 262

Query: 117 PQLLSLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNL 176
             +  L L+ N LT +      GL  LQEL+L+ N + RI+P A+     L  L L  N 
Sbjct: 263 SNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNH 322

Query: 177 LRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLR---EISDYAL 233
           L  +D   F  L  L  L IG N+V  I D  FR L++L++L L    +    E  + A 
Sbjct: 323 LSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAF 382

Query: 234 EGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGL- 292
            GL  L  L    N++  + ++A   +  L+ LDL+ N +  +    F+ M  L++L L 
Sbjct: 383 SGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLN 442

Query: 293 -------------------NNMEELV------------------SIDKFALVNLPELTKL 315
                              NN +  V                  S D F   + P   K 
Sbjct: 443 TSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFP---KP 499

Query: 316 DITNNPR---------LSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGL 366
            IT  P          LSFI   A      M      +N L  LH   +E+  +L+  G 
Sbjct: 500 QITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNEL--LHDAEMENYAHLRAQG- 556

Query: 367 HGNPIRCDCVIRWANATGTRVRFIEPQSTLCAEPPDL-QRLPVREVPFREMTDHCLPLIS 425
            G  +    ++R        V F       C           V+     ++T + LP  +
Sbjct: 557 -GEVMEYTTILRLRE-----VEFASEGKYQCVISNHFGSSYSVKA----KLTVNMLPSFT 606

Query: 426 PRSFPPSLQVASGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEGTLE-L 484
               P  L + +G    L C A+  P P+I W    G    PA   RR  V PE  +  +
Sbjct: 607 KT--PMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDF-PAARERRMHVMPEDDVFFI 663

Query: 485 RRVTAEEAGLYTCVAQNLVGADTKTVSVVV 514
             V  E+ G+Y+C AQN  G+ +   ++ V
Sbjct: 664 VDVKIEDIGVYSCTAQNSAGSISANATLTV 693



 Score = 33.5 bits (75), Expect = 0.70
 Identities = 24/84 (28%), Positives = 37/84 (44%), Gaps = 11/84 (13%)

Query: 435 VASGESMVLHCRALAEPEPEIYWV-TPAGLRLTPAH---AGRRYRVYPEGTLELRRVTAE 490
           V  GE+ VL C A   P P++ W    + L +T  H   AG +  +  +  +        
Sbjct: 708 VTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDV-------S 760

Query: 491 EAGLYTCVAQNLVGADTKTVSVVV 514
           +AG YTC   N +G +   V + V
Sbjct: 761 DAGKYTCEMSNTLGTERGNVRLSV 784


>gi|209862903 leucine-rich repeats and immunoglobulin-like domains 3
           isoform 1 [Homo sapiens]
          Length = 1059

 Score =  122 bits (305), Expect = 2e-27
 Identities = 138/491 (28%), Positives = 200/491 (40%), Gaps = 42/491 (8%)

Query: 53  VDCNDLFLTAVPPALPAGTQTLLLQ--SNSIVRVDQSELGYLANLTELDLSQNSFSDARD 110
           V  N+  L  +P   P      LL    N IV +    L    +L  LDLS N+ S+ + 
Sbjct: 43  VKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQT 102

Query: 111 CDFHALPQLLSLHLEENQLTRLEDHSFAGLAS-LQELYLNHNQLYRIAPRAFSGLSNLLR 169
             F AL QL  L+L  N++T +E   F  LA+ L  L LN N++  I P+ F  L  L  
Sbjct: 103 A-FPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFK-LPQLQH 159

Query: 170 LHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREIS 229
           L LN N ++ +D   F+ L  L+ L +  N V  ++D  F  L+N+  L L   NL EI+
Sbjct: 160 LELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEIT 219

Query: 230 DYALEGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDF-----ANM 284
              L GL  L+ L    N + R+   A E    L  LDL  N L R+    F      N 
Sbjct: 220 KGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNT 279

Query: 285 LH-------------------LKELGLNNMEELVSIDKF--ALVNLPELTKLDITNNPRL 323
           LH                   LK L L N E   +I+    A   L +L +L +  N R+
Sbjct: 280 LHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGN-RI 338

Query: 324 SFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRCDCVIRWANAT 383
             I  +AF  L  +E L L++NA+ +L       +  LQ++ L+ + + CDC ++W    
Sbjct: 339 RSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQW 398

Query: 384 GTRVRFIEPQSTLCAEPPDLQRLPVREVPFREMTDHCLPLISPRSFPPSLQVASGESMVL 443
                F    +  CA P  L+   +  V          P       P +     G ++  
Sbjct: 399 VAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSNLSF 458

Query: 444 HCRALAEPEPEIYWVTPAGLRL-------TPAHAGRRYRVYPEGT--LELRRVTAEEAGL 494
            C A +  +  + +       L         AH   +     E T  L LR V     G 
Sbjct: 459 ICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGK 518

Query: 495 YTCVAQNLVGA 505
           Y CV  N  G+
Sbjct: 519 YQCVISNHFGS 529



 Score =  115 bits (288), Expect = 1e-25
 Identities = 137/510 (26%), Positives = 200/510 (39%), Gaps = 75/510 (14%)

Query: 60  LTAVPPA---LPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHAL 116
           ++A+PP    LP   Q L L  N I  VD      L  L  L + +N  +   D  F  L
Sbjct: 144 ISAIPPKMFKLPQ-LQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGL 202

Query: 117 PQLLSLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNL 176
             +  L L+ N LT +      GL  LQEL+L+ N + RI+P A+     L  L L  N 
Sbjct: 203 SNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNH 262

Query: 177 LRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLR---EISDYAL 233
           L  +D   F  L  L  L IG N+V  I D  FR L++L++L L    +    E  + A 
Sbjct: 263 LSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAF 322

Query: 234 EGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGL- 292
            GL  L  L    N++  + ++A   +  L+ LDL+ N +  +    F+ M  L++L L 
Sbjct: 323 SGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLN 382

Query: 293 -------------------NNMEELV------------------SIDKFALVNLPELTKL 315
                              NN +  V                  S D F   + P   K 
Sbjct: 383 TSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFP---KP 439

Query: 316 DITNNPR---------LSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGL 366
            IT  P          LSFI   A      M      +N L  LH   +E+  +L+  G 
Sbjct: 440 QITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNEL--LHDAEMENYAHLRAQG- 496

Query: 367 HGNPIRCDCVIRWANATGTRVRFIEPQSTLCAEPPDL-QRLPVREVPFREMTDHCLPLIS 425
            G  +    ++R        V F       C           V+     ++T + LP  +
Sbjct: 497 -GEVMEYTTILRLRE-----VEFASEGKYQCVISNHFGSSYSVKA----KLTVNMLPSFT 546

Query: 426 PRSFPPSLQVASGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEGTLE-L 484
               P  L + +G    L C A+  P P+I W    G    PA   RR  V PE  +  +
Sbjct: 547 KT--PMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDF-PAARERRMHVMPEDDVFFI 603

Query: 485 RRVTAEEAGLYTCVAQNLVGADTKTVSVVV 514
             V  E+ G+Y+C AQN  G+ +   ++ V
Sbjct: 604 VDVKIEDIGVYSCTAQNSAGSISANATLTV 633



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 80/322 (24%), Positives = 129/322 (40%), Gaps = 76/322 (23%)

Query: 124 LEENQLTRLEDHSFAGLASLQELYLNHNQLYRI--------------------------- 156
           L  N+L+ ++  S + L SL+E+ LN+N+L  I                           
Sbjct: 21  LSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEH 80

Query: 157 -------------------APRAFSGLSNLLRLHLNSNLLRAIDSRWFE----------- 186
                                 AF  L  L  L+LNSN + +++  +F+           
Sbjct: 81  LKEFQSLETLDLSSNNISELQTAFPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLLVLKL 139

Query: 187 -------------MLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYAL 233
                         LP L+ L +  NK+  +  + F+ L  L+SL +    + ++ D A 
Sbjct: 140 NRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAF 199

Query: 234 EGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLN 293
            GL ++E L    N L  + +  L  +  L+ L L++N + R+ P  +     L EL L 
Sbjct: 200 WGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDL- 258

Query: 294 NMEELVSIDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQ 353
               L  +D  + + L  L  L I NN R+S+I   AF  L  ++TL L NN +S   + 
Sbjct: 259 TFNHLSRLDDSSFLGLSLLNTLHIGNN-RVSYIADCAFRGLSSLKTLDLKNNEISWTIED 317

Query: 354 ---TVESLPNLQEVGLHGNPIR 372
                  L  L+ + L GN IR
Sbjct: 318 MNGAFSGLDKLRRLILQGNRIR 339



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 49/194 (25%), Positives = 82/194 (42%), Gaps = 27/194 (13%)

Query: 201 VDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARVP------- 253
           VD +L  +   L ++    L+   L  I   ++  LQSL  +   +N+L  +P       
Sbjct: 2   VDVLLLFSLCLLFHISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSA 61

Query: 254 ---------RRALEQVP-------GLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEE 297
                     R +E +P        L+ LDL+ N +  +     A  L LK L LN+   
Sbjct: 62  NITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQTAFPA--LQLKYLYLNS-NR 118

Query: 298 LVSIDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVES 357
           + S++     NL     +   N  R+S I P+ F  LPQ++ L LN N +  +   T + 
Sbjct: 119 VTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMF-KLPQLQHLELNRNKIKNVDGLTFQG 177

Query: 358 LPNLQEVGLHGNPI 371
           L  L+ + +  N +
Sbjct: 178 LGALKSLKMQRNGV 191



 Score = 36.6 bits (83), Expect = 0.083
 Identities = 38/141 (26%), Positives = 65/141 (46%), Gaps = 5/141 (3%)

Query: 267 DLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNPRLSFI 326
           DL+ N L  +     +++  L+E+ LNN  EL +I     V+   +T L +  N R+  I
Sbjct: 20  DLSHNRLSFIKASSMSHLQSLREVKLNN-NELETIPNLGPVS-ANITLLSLAGN-RIVEI 76

Query: 327 HPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRCDCVIRWANATGTR 386
            P        +ETL L++N +S L  QT      L+ + L+ N +       + N   T 
Sbjct: 77  LPEHLKEFQSLETLDLSSNNISEL--QTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTL 134

Query: 387 VRFIEPQSTLCAEPPDLQRLP 407
           +     ++ + A PP + +LP
Sbjct: 135 LVLKLNRNRISAIPPKMFKLP 155



 Score = 33.5 bits (75), Expect = 0.70
 Identities = 24/84 (28%), Positives = 37/84 (44%), Gaps = 11/84 (13%)

Query: 435 VASGESMVLHCRALAEPEPEIYWV-TPAGLRLTPAH---AGRRYRVYPEGTLELRRVTAE 490
           V  GE+ VL C A   P P++ W    + L +T  H   AG +  +  +  +        
Sbjct: 648 VTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDV-------S 700

Query: 491 EAGLYTCVAQNLVGADTKTVSVVV 514
           +AG YTC   N +G +   V + V
Sbjct: 701 DAGKYTCEMSNTLGTERGNVRLSV 724


>gi|7662320 leucine-rich repeats and immunoglobulin-like domains 2
           [Homo sapiens]
          Length = 1065

 Score =  120 bits (301), Expect = 4e-27
 Identities = 115/415 (27%), Positives = 184/415 (44%), Gaps = 36/415 (8%)

Query: 68  PAGTQTLL-LQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEE 126
           P    TLL L  N I  ++   L +   L  LDLS N  S+ +   F  + QL  L+L  
Sbjct: 118 PTSNITLLSLVHNIIPEINAQALQFYPALESLDLSSNIISEIKTSSFPRM-QLKYLNLSN 176

Query: 127 NQLTRLEDHSFAGL-ASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWF 185
           N++T LE   F  L +SL  + LN N++  I P+ F  L +L  L L  N ++ ++   F
Sbjct: 177 NRITTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIFK-LPHLQFLELKRNRIKIVEGLTF 235

Query: 186 EMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFY 245
           + L +L  L +  N +  + D  F  L N+  L L   NL  ++   L GL+ L+ L   
Sbjct: 236 QGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVS 295

Query: 246 DNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNN----------- 294
            N + R+   A E    L  LDL+ N L R+    F  +  L+ L L +           
Sbjct: 296 QNAIERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVF 355

Query: 295 --MEELVSID-------------KFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMET 339
             +  L ++D               A   L  LTKL +  N ++  I  +AF  L  +E 
Sbjct: 356 RFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGN-QIKSITKKAFIGLESLEH 414

Query: 340 LMLNNNALSALHQQTVESLPNLQEVGLHGNPIRCDCVIRWANATGTRVRFIEPQSTLCAE 399
           L LNNNA+ ++ Q+   S  +L+E+ L+ + + CDC ++W         F    +  CA 
Sbjct: 415 LDLNNNAIMSI-QENAFSQTHLKELILNTSSLLCDCHLKWLLQWLVDNNFQHSVNVSCAH 473

Query: 400 PPDLQRLPVREVPFREMTDHCLPLISP--RSFPPSLQVASGESMVLHCRALAEPE 452
           P  L    +  V  ++    C   + P  R+ P ++    G ++ L C A++  +
Sbjct: 474 PEWLAGQSILNVDLKDFV--CDDFLKPQIRTHPETIIALRGMNVTLTCTAVSSSD 526



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 48/177 (27%), Positives = 82/177 (46%), Gaps = 11/177 (6%)

Query: 203 AILDMNFRPLANL------RSLVLAGMNLREISD--YALEGLQSLESLSFYDNQLARVPR 254
           AILD +   L+N       ++L    MN  E+++  Y  E   ++  LS   N +  +  
Sbjct: 78  AILDFSHNRLSNWNISLESQTLQEVKMNYNELTEIPYFGEPTSNITLLSLVHNIIPEINA 137

Query: 255 RALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTK 314
           +AL+  P L+ LDL+ N +  +    F  M  LK L L+N   + +++     NL     
Sbjct: 138 QALQFYPALESLDLSSNIISEIKTSSFPRM-QLKYLNLSN-NRITTLEAGCFDNLSSSLL 195

Query: 315 LDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPI 371
           +   N  R+S I P+ F  LP ++ L L  N +  +   T + L +L+ + +  N I
Sbjct: 196 VVKLNRNRMSMIPPKIF-KLPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGI 251



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 29/86 (33%), Positives = 40/86 (46%), Gaps = 2/86 (2%)

Query: 430 PPSLQVASGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEGTLE-LRRVT 488
           P  L + +G    L C A   P P+I W    G    PA   RR  V PE  +  +  V 
Sbjct: 608 PMDLTIRTGAMARLECAAEGHPAPQISWQKDGGTDF-PAARERRMHVMPEDDVFFIANVK 666

Query: 489 AEEAGLYTCVAQNLVGADTKTVSVVV 514
            E+ G+Y+C+AQN  G  +   S+ V
Sbjct: 667 IEDMGIYSCMAQNTAGGLSANASLTV 692



 Score = 36.6 bits (83), Expect = 0.083
 Identities = 22/72 (30%), Positives = 30/72 (41%), Gaps = 3/72 (4%)

Query: 435 VASGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEGTLELRRVTAEEAGL 494
           V  GE+ VL C A   P P + W    G  L      R +       L +     E+AG 
Sbjct: 707 VTRGETAVLQCIAGGSPAPRLNWTKDDGPLLV---TERHFFAAANQLLIIVDAGLEDAGK 763

Query: 495 YTCVAQNLVGAD 506
           YTC+  N +G +
Sbjct: 764 YTCIMSNTLGTE 775


>gi|157694513 leucine-rich repeat-containing G protein-coupled
           receptor 4 [Homo sapiens]
          Length = 951

 Score =  119 bits (297), Expect = 1e-26
 Identities = 102/365 (27%), Positives = 161/365 (44%), Gaps = 51/365 (13%)

Query: 53  VDCNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCD 112
           VDC+   LTAVP  L A TQ L +  N+I ++ +        L EL L+ N  S      
Sbjct: 41  VDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKA 100

Query: 113 FHALPQLLSLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHL 172
              L +L  L L+ NQL  +   +  GL++LQ L L+ N +  +   +F GL  L  L L
Sbjct: 101 LSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWL 160

Query: 173 NSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYA 232
           + N L  +       LP L+ L +  NK+ +I D  F  L++L  L L    +R +S + 
Sbjct: 161 DDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHC 220

Query: 233 LEGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGL 292
            +GL +LE+L    N L   P +A++ +P LK L  + N +  +  G F           
Sbjct: 221 FDGLDNLETLDLNYNNLGEFP-QAIKALPSLKELGFHSNSISVIPDGAFDGN-------- 271

Query: 293 NNMEELVSIDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQ 352
                            P L  + + +NP LSF+   AFH+L  + +L++   ++     
Sbjct: 272 -----------------PLLRTIHLYDNP-LSFVGNSAFHNLSDLHSLVIRGASM----- 308

Query: 353 QTVESLPNLQEVGLHGNPIRCDCVIRWANATGTRVRFIEPQSTLCAEPPDLQRLP----- 407
             V+  PNL    +H         +     TGT++  I   + LC E   L+ L      
Sbjct: 309 --VQQFPNLTGT-VH---------LESLTLTGTKISSI--PNNLCQEQKMLRTLDLSYNN 354

Query: 408 VREVP 412
           +R++P
Sbjct: 355 IRDLP 359



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 38/124 (30%), Positives = 63/124 (50%), Gaps = 6/124 (4%)

Query: 95  LTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELYLNHNQLY 154
           L  LDLS N+  D     F+    L  + L+ NQ+ ++++ +F GL SL+ L L+ N ++
Sbjct: 345 LRTLDLSYNNIRDLPS--FNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIH 402

Query: 155 RIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLAN 214
            I  RAF+ L  +  L ++ N L +  +     L  L+  ++G  K+   L    +   N
Sbjct: 403 EIHSRAFATLGPITNLDVSFNELTSFPTEGLNGLNQLK--LVGNFKLKEALAA--KDFVN 458

Query: 215 LRSL 218
           LRSL
Sbjct: 459 LRSL 462



 Score = 46.6 bits (109), Expect = 8e-05
 Identities = 41/136 (30%), Positives = 67/136 (49%), Gaps = 16/136 (11%)

Query: 119 LLSLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLR 178
           L +L L  N +  L   SF G  +L+E+ L  NQ+Y+I    F GL +L  L L+ NL+ 
Sbjct: 345 LRTLDLSYNNIRDLP--SFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIH 402

Query: 179 AIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMN-LREISDYALEGLQ 237
            I SR F  L  +             LD++F  L +  +  L G+N L+ + ++ L+  +
Sbjct: 403 EIHSRAFATLGPI-----------TNLDVSFNELTSFPTEGLNGLNQLKLVGNFKLK--E 449

Query: 238 SLESLSFYDNQLARVP 253
           +L +  F + +   VP
Sbjct: 450 ALAAKDFVNLRSLSVP 465



 Score = 33.1 bits (74), Expect = 0.92
 Identities = 26/96 (27%), Positives = 42/96 (43%), Gaps = 1/96 (1%)

Query: 72  QTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTR 131
           + + LQ N I ++ +     L +L  LDLS+N   +     F  L  + +L +  N+LT 
Sbjct: 368 EEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTS 427

Query: 132 LEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNL 167
                  GL  L +L  N      +A + F  L +L
Sbjct: 428 FPTEGLNGLNQL-KLVGNFKLKEALAAKDFVNLRSL 462


>gi|194440719 chondroadherin-like [Homo sapiens]
          Length = 762

 Score =  118 bits (296), Expect = 2e-26
 Identities = 113/380 (29%), Positives = 152/380 (40%), Gaps = 73/380 (19%)

Query: 28  PCPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQS 87
           PCP  C C       P S +       C    L AVP   P+ TQ L             
Sbjct: 395 PCPRACVC------VPESRHSS-----CEGCGLQAVPRGFPSDTQLL------------- 430

Query: 88  ELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELY 147
                      DL +N F       F  L  L+SLHL+   +  LE  + AGL  L  LY
Sbjct: 431 -----------DLRRNHFPSVPRAAFPGLGHLVSLHLQHCGIAELEAGALAGLGRLIYLY 479

Query: 148 LNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDM 207
           L+ NQL  ++  A  G   L  L+L  N    +       LP+L  L +  N VD +   
Sbjct: 480 LSDNQLAGLSAAALEGAPRLGYLYLERNRFLQVPGAALRALPSLFSLHLQDNAVDRLAPG 539

Query: 208 NFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARVPRRALEQVPGLKFLD 267
           +      LR + L+G  + E+S  AL   + LE L    NQL  VP  ALE +P L  L 
Sbjct: 540 DLGRTRALRWVYLSGNRITEVSLGALGPARELEKLHLDRNQLREVPTGALEGLPALLELQ 599

Query: 268 LNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNPRLSFIH 327
           L+ NPL+ +  G F      + +G  +++ L                    N+  L  I 
Sbjct: 600 LSGNPLRALRDGAF------QPVG-RSLQHL------------------FLNSSGLEQIC 634

Query: 328 PRAFHHL-PQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRCDCVI----RWANA 382
           P AF  L P +++L L  N L AL    + SL  L+ + L  NP  CDC +    RW   
Sbjct: 635 PGAFSGLGPGLQSLHLQKNQLRAL--PALPSLSQLELIDLSSNPFHCDCQLLPLHRWLTG 692

Query: 383 TGTRVRFIEPQSTLCAEPPD 402
              RV         CA PP+
Sbjct: 693 LNLRV------GATCATPPN 706



 Score =  112 bits (279), Expect = 2e-24
 Identities = 102/350 (29%), Positives = 140/350 (40%), Gaps = 63/350 (18%)

Query: 29  CPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQSE 88
           CP  C C         +S R    V C    LT VP A+P  TQ L LQ N +  +  + 
Sbjct: 33  CPQACICD--------NSRRH---VACRYQNLTEVPDAIPELTQRLDLQGNLLKVIPAAA 81

Query: 89  LGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELYL 148
              + +LT LDL         +  F  L +LL L+L  N L  L   +  GL SL+ L L
Sbjct: 82  FQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQEALDGLGSLRRLEL 141

Query: 149 NHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMN 208
             N L  + P  F  L  L  L+L  N L  + +                        M 
Sbjct: 142 EGNALEELRPGTFGALGALATLNLAHNALVYLPA------------------------MA 177

Query: 209 FRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDL 268
           F+ L  +R L L+   L  ++  AL GL +L  LS + N+L  +P   L Q  GL  L+L
Sbjct: 178 FQGLLRVRWLRLSHNALSVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLEL 237

Query: 269 NKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNPRLSFIHP 328
             NPL   G  D   +  L+EL                          + +   L  + P
Sbjct: 238 GHNPLTYAGEEDGLALPGLREL--------------------------LLDGGALQALGP 271

Query: 329 RAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRCDCVIR 378
           RAF H P++ TL L  N L  L    ++    L+ + L GNP+ C C  R
Sbjct: 272 RAFAHCPRLHTLDLRGNQLDTL--PPLQGPGQLRRLRLQGNPLWCGCQAR 319


>gi|62912470 leucine-rich repeat-containing G protein-coupled
           receptor 6 isoform 1 [Homo sapiens]
          Length = 967

 Score =  118 bits (295), Expect = 2e-26
 Identities = 99/321 (30%), Positives = 148/321 (46%), Gaps = 38/321 (11%)

Query: 24  PWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQTLLLQSNSIVR 83
           P    CP  C CQ               + DC++L L+AVP                   
Sbjct: 30  PGPTACPAPCHCQ---------EDGIMLSADCSELGLSAVP------------------- 61

Query: 84  VDQSELGYLANLTE-LDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLAS 142
                 G L  LT  LDLS N+ ++ +   FH L  L  L L  N L+ +   +F+GL S
Sbjct: 62  ------GDLDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYS 115

Query: 143 LQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVD 202
           L+ L L +NQL  I   A   L +L  L L++NL+  +  R FE L +L  L +  N + 
Sbjct: 116 LKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALT 175

Query: 203 AILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARVPRRALEQVPG 262
            I       L  L+++ LA   +  I DYA + L SL  L  ++N++  +   + E +  
Sbjct: 176 EIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHN 235

Query: 263 LKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNPR 322
           L+ LDLN N LQ   P     +  L+ELG +N   + +I + A +  P L  +   +NP 
Sbjct: 236 LETLDLNYNKLQEF-PVAIRTLGRLQELGFHN-NNIKAIPEKAFMGNPLLQTIHFYDNP- 292

Query: 323 LSFIHPRAFHHLPQMETLMLN 343
           + F+   AF +LP++ TL LN
Sbjct: 293 IQFVGRSAFQYLPKLHTLSLN 313



 Score = 96.7 bits (239), Expect = 7e-20
 Identities = 88/309 (28%), Positives = 136/309 (44%), Gaps = 46/309 (14%)

Query: 64  PPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLH 123
           P A PA       +   ++  D SELG  A   +LD                 P    L 
Sbjct: 32  PTACPAPCHCQ--EDGIMLSADCSELGLSAVPGDLD-----------------PLTAYLD 72

Query: 124 LEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSR 183
           L  N LT L+   F  L  L+EL L+ N L  I  +AFSGL +L  L L +N L  I + 
Sbjct: 73  LSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAE 132

Query: 184 WFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLS 243
               LP+L+ L +  N +  + + +F  L++LR L L    L EI   AL  L +L++++
Sbjct: 133 ALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMT 192

Query: 244 FYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDK 303
              N+++ +P  A + +  L  L L+ N +Q +G   F         GL+N+E L     
Sbjct: 193 LALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFE--------GLHNLETL----- 239

Query: 304 FALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQE 363
                       D+  N    F  P A   L +++ L  +NN + A+ ++     P LQ 
Sbjct: 240 ------------DLNYNKLQEF--PVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQT 285

Query: 364 VGLHGNPIR 372
           +  + NPI+
Sbjct: 286 IHFYDNPIQ 294



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 71/307 (23%), Positives = 115/307 (37%), Gaps = 68/307 (22%)

Query: 74  LLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLE 133
           L L  N++  +    L  L  L  + L+ N  S   D  F  L  L+ LHL  N++  L 
Sbjct: 167 LWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLG 226

Query: 134 DHSFAGLASLQELYLNHNQLYR-----------------------IAPRAFSGLSNLLRL 170
            HSF GL +L+ L LN+N+L                         I  +AF G   L  +
Sbjct: 227 THSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTI 286

Query: 171 HLNSNLLRAIDSRWFEMLPNLEILMIGGNK-VDAILDMNFRPLANLRSLVLAGMNLR--- 226
           H   N ++ +    F+ LP L  L + G   +    D+       + +L  AG+ L    
Sbjct: 287 HFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSG 346

Query: 227 -----------EISDYALEGL------QSLESLSFYDNQLARVPRRALEQVPGLKFLDLN 269
                      E+S   +E L      Q LE +    N++  +      Q+  L+ LDL+
Sbjct: 347 MCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLS 406

Query: 270 KNPLQRVGPGDFANM------------------------LHLKELGLNNMEELVSIDKFA 305
            N ++ + P  F+ +                        +HLK  G   + +  S D F 
Sbjct: 407 WNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFP 466

Query: 306 LVNLPEL 312
            + + E+
Sbjct: 467 KLRILEV 473



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 44/138 (31%), Positives = 66/138 (47%), Gaps = 14/138 (10%)

Query: 116 LPQLLSLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSN 175
           LP+L  L L  NQ+  L   S      L+E+ L HN+++ I    FS LS+L  L L+ N
Sbjct: 351 LPRLRVLELSHNQIEELP--SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWN 408

Query: 176 LLRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEG 235
            +R+I    F  L +L  L +  N++  +      PLA L  L    M+L+   + AL  
Sbjct: 409 AIRSIHPEAFSTLHSLVKLDLTDNQLTTL------PLAGLGGL----MHLKLKGNLALS- 457

Query: 236 LQSLESLSFYDNQLARVP 253
            Q+    SF   ++  VP
Sbjct: 458 -QAFSKDSFPKLRILEVP 474


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.135    0.418 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,995,790
Number of Sequences: 37866
Number of extensions: 1379117
Number of successful extensions: 8156
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 294
Number of HSP's successfully gapped in prelim test: 266
Number of HSP's that attempted gapping in prelim test: 3619
Number of HSP's gapped (non-prelim): 2516
length of query: 713
length of database: 18,247,518
effective HSP length: 109
effective length of query: 604
effective length of database: 14,120,124
effective search space: 8528554896
effective search space used: 8528554896
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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