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Search of human proteins with 42544231
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens]
(713 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens] 1441 0.0
gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens] 1441 0.0
gi|153791330 leucine rich repeat neuronal 1 [Homo sapiens] 652 0.0
gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens] 638 0.0
gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens] 638 0.0
gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens] 638 0.0
gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom... 185 1e-46
gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo... 167 3e-41
gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens] 167 4e-41
gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo... 163 6e-40
gi|76880480 hypothetical protein LOC9865 [Homo sapiens] 138 2e-32
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 134 3e-31
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 134 3e-31
gi|31542244 leucine rich repeat and fibronectin type III domain ... 132 1e-30
gi|225579152 insulin-like growth factor binding protein, acid la... 130 6e-30
gi|4826772 insulin-like growth factor binding protein, acid labi... 130 6e-30
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] 128 2e-29
gi|54607118 leucine-rich repeats and immunoglobulin-like domains... 128 2e-29
gi|198041768 synleurin [Homo sapiens] 128 2e-29
gi|27363458 leucine rich repeat and fibronectin type III domain ... 126 6e-29
gi|13375646 leucine rich repeat and fibronectin type III domain ... 124 2e-28
gi|4504379 leucine-rich repeat-containing G protein-coupled rece... 124 3e-28
gi|149773484 leucine rich repeat and fibronectin type III domain... 124 4e-28
gi|51317373 netrin-G1 ligand [Homo sapiens] 123 7e-28
gi|40255157 leucine-rich repeats and immunoglobulin-like domains... 122 2e-27
gi|209862903 leucine-rich repeats and immunoglobulin-like domain... 122 2e-27
gi|7662320 leucine-rich repeats and immunoglobulin-like domains ... 120 4e-27
gi|157694513 leucine-rich repeat-containing G protein-coupled re... 119 1e-26
gi|194440719 chondroadherin-like [Homo sapiens] 118 2e-26
gi|62912470 leucine-rich repeat-containing G protein-coupled rec... 118 2e-26
>gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens]
Length = 713
Score = 1441 bits (3731), Expect = 0.0
Identities = 713/713 (100%), Positives = 713/713 (100%)
Query: 1 MRLLVAPLLLAWVAGATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFL 60
MRLLVAPLLLAWVAGATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFL
Sbjct: 1 MRLLVAPLLLAWVAGATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFL 60
Query: 61 TAVPPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLL 120
TAVPPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLL
Sbjct: 61 TAVPPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLL 120
Query: 121 SLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAI 180
SLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAI
Sbjct: 121 SLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAI 180
Query: 181 DSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLE 240
DSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLE
Sbjct: 181 DSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLE 240
Query: 241 SLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVS 300
SLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVS
Sbjct: 241 SLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVS 300
Query: 301 IDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPN 360
IDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPN
Sbjct: 301 IDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPN 360
Query: 361 LQEVGLHGNPIRCDCVIRWANATGTRVRFIEPQSTLCAEPPDLQRLPVREVPFREMTDHC 420
LQEVGLHGNPIRCDCVIRWANATGTRVRFIEPQSTLCAEPPDLQRLPVREVPFREMTDHC
Sbjct: 361 LQEVGLHGNPIRCDCVIRWANATGTRVRFIEPQSTLCAEPPDLQRLPVREVPFREMTDHC 420
Query: 421 LPLISPRSFPPSLQVASGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEG 480
LPLISPRSFPPSLQVASGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEG
Sbjct: 421 LPLISPRSFPPSLQVASGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEG 480
Query: 481 TLELRRVTAEEAGLYTCVAQNLVGADTKTVSVVVGRALLQPGRDEGQGLELRVQETHPYH 540
TLELRRVTAEEAGLYTCVAQNLVGADTKTVSVVVGRALLQPGRDEGQGLELRVQETHPYH
Sbjct: 481 TLELRRVTAEEAGLYTCVAQNLVGADTKTVSVVVGRALLQPGRDEGQGLELRVQETHPYH 540
Query: 541 ILLSWVTPPNTVSTNLTWSSASSLRGQGATALARLPRGTHSYNITRLLQATEYWACLQVA 600
ILLSWVTPPNTVSTNLTWSSASSLRGQGATALARLPRGTHSYNITRLLQATEYWACLQVA
Sbjct: 541 ILLSWVTPPNTVSTNLTWSSASSLRGQGATALARLPRGTHSYNITRLLQATEYWACLQVA 600
Query: 601 FADAHTQLACVWARTKEATSCHRALGDRPGLIAILALAVLLLAAGLAAHLGTGQPRKGVG 660
FADAHTQLACVWARTKEATSCHRALGDRPGLIAILALAVLLLAAGLAAHLGTGQPRKGVG
Sbjct: 601 FADAHTQLACVWARTKEATSCHRALGDRPGLIAILALAVLLLAAGLAAHLGTGQPRKGVG 660
Query: 661 GRRPLPPAWAFWGWSAPSVRVVSAPLVLPWNPGRKLPRSSEGETLLPPLSQNS 713
GRRPLPPAWAFWGWSAPSVRVVSAPLVLPWNPGRKLPRSSEGETLLPPLSQNS
Sbjct: 661 GRRPLPPAWAFWGWSAPSVRVVSAPLVLPWNPGRKLPRSSEGETLLPPLSQNS 713
>gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens]
Length = 713
Score = 1441 bits (3731), Expect = 0.0
Identities = 713/713 (100%), Positives = 713/713 (100%)
Query: 1 MRLLVAPLLLAWVAGATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFL 60
MRLLVAPLLLAWVAGATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFL
Sbjct: 1 MRLLVAPLLLAWVAGATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFL 60
Query: 61 TAVPPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLL 120
TAVPPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLL
Sbjct: 61 TAVPPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLL 120
Query: 121 SLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAI 180
SLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAI
Sbjct: 121 SLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAI 180
Query: 181 DSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLE 240
DSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLE
Sbjct: 181 DSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLE 240
Query: 241 SLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVS 300
SLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVS
Sbjct: 241 SLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVS 300
Query: 301 IDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPN 360
IDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPN
Sbjct: 301 IDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPN 360
Query: 361 LQEVGLHGNPIRCDCVIRWANATGTRVRFIEPQSTLCAEPPDLQRLPVREVPFREMTDHC 420
LQEVGLHGNPIRCDCVIRWANATGTRVRFIEPQSTLCAEPPDLQRLPVREVPFREMTDHC
Sbjct: 361 LQEVGLHGNPIRCDCVIRWANATGTRVRFIEPQSTLCAEPPDLQRLPVREVPFREMTDHC 420
Query: 421 LPLISPRSFPPSLQVASGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEG 480
LPLISPRSFPPSLQVASGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEG
Sbjct: 421 LPLISPRSFPPSLQVASGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEG 480
Query: 481 TLELRRVTAEEAGLYTCVAQNLVGADTKTVSVVVGRALLQPGRDEGQGLELRVQETHPYH 540
TLELRRVTAEEAGLYTCVAQNLVGADTKTVSVVVGRALLQPGRDEGQGLELRVQETHPYH
Sbjct: 481 TLELRRVTAEEAGLYTCVAQNLVGADTKTVSVVVGRALLQPGRDEGQGLELRVQETHPYH 540
Query: 541 ILLSWVTPPNTVSTNLTWSSASSLRGQGATALARLPRGTHSYNITRLLQATEYWACLQVA 600
ILLSWVTPPNTVSTNLTWSSASSLRGQGATALARLPRGTHSYNITRLLQATEYWACLQVA
Sbjct: 541 ILLSWVTPPNTVSTNLTWSSASSLRGQGATALARLPRGTHSYNITRLLQATEYWACLQVA 600
Query: 601 FADAHTQLACVWARTKEATSCHRALGDRPGLIAILALAVLLLAAGLAAHLGTGQPRKGVG 660
FADAHTQLACVWARTKEATSCHRALGDRPGLIAILALAVLLLAAGLAAHLGTGQPRKGVG
Sbjct: 601 FADAHTQLACVWARTKEATSCHRALGDRPGLIAILALAVLLLAAGLAAHLGTGQPRKGVG 660
Query: 661 GRRPLPPAWAFWGWSAPSVRVVSAPLVLPWNPGRKLPRSSEGETLLPPLSQNS 713
GRRPLPPAWAFWGWSAPSVRVVSAPLVLPWNPGRKLPRSSEGETLLPPLSQNS
Sbjct: 661 GRRPLPPAWAFWGWSAPSVRVVSAPLVLPWNPGRKLPRSSEGETLLPPLSQNS 713
>gi|153791330 leucine rich repeat neuronal 1 [Homo sapiens]
Length = 716
Score = 652 bits (1681), Expect = 0.0
Identities = 328/591 (55%), Positives = 425/591 (71%), Gaps = 6/591 (1%)
Query: 29 CPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQSE 88
CP C C+IRPW+TP+S+YREATTVDCNDL LT +P L + TQ LLLQSN+I + E
Sbjct: 32 CPQLCVCEIRPWFTPQSTYREATTVDCNDLRLTRIPSNLSSDTQVLLLQSNNIAKT-VDE 90
Query: 89 LGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELYL 148
L L NLTELD SQN+F++ ++ L QL +LHLEENQ+T + D+ L++LQELY+
Sbjct: 91 LQQLFNLTELDFSQNNFTNIKEVGLANLTQLTTLHLEENQITEMTDYCLQDLSNLQELYI 150
Query: 149 NHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMN 208
NHNQ+ I+ AF+GL NLLRLHLNSN L+ IDSRWF+ PNLEILMIG N V ILDMN
Sbjct: 151 NHNQISTISAHAFAGLKNLLRLHLNSNKLKVIDSRWFDSTPNLEILMIGENPVIGILDMN 210
Query: 209 FRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDL 268
F+PLANLRSLVLAGM L +I AL GL SLESLSFYDN+L +VP+ AL++VP LKFLDL
Sbjct: 211 FKPLANLRSLVLAGMYLTDIPGNALVGLDSLESLSFYDNKLVKVPQLALQKVPNLKFLDL 270
Query: 269 NKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNPRLSFIHP 328
NKNP+ ++ GDF NML LKELG+NNM ELVS+D++AL NLPELTKL+ TNNP+LS+IH
Sbjct: 271 NKNPIHKIQEGDFKNMLRLKELGINNMGELVSVDRYALDNLPELTKLEATNNPKLSYIHR 330
Query: 329 RAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRCDCVIRWANATGTRVR 388
AF +P +E+LMLNNNAL+A++Q+TVESLPNL+E+ +H NP+RCDCVI W N+ T +R
Sbjct: 331 LAFRSVPALESLMLNNNALNAIYQKTVESLPNLREISIHSNPLRCDCVIHWINSNKTNIR 390
Query: 389 FIEPQSTLCAEPPDLQRLPVREVPFREMTDHCLPLISPRSFPPSLQVASGESMVLHCRAL 448
F+EP S CA PP+ + V+EV ++ ++ CLP+IS SFP L V G ++ L CRA+
Sbjct: 391 FMEPLSMFCAMPPEYKGHQVKEVLIQDSSEQCLPMISHDSFPNRLNVDIGTTVFLDCRAM 450
Query: 449 AEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEGTLELRRVTAEEAGLYTCVAQNLVGADTK 508
AEPEPEIYWVTP G ++T +Y++ EGTLE+ + E++G YTCVAQN+ GADT+
Sbjct: 451 AEPEPEIYWVTPIGNKITVETLSDKYKLSSEGTLEISNIQIEDSGRYTCVAQNVQGADTR 510
Query: 509 TVSVVVGRALLQPGRDEGQGLELRVQETHPYHILLSWVTPPNTVSTNLTWSSAS-SLRGQ 567
++ V LL D Q L++ V++T + IL+SW N +++NL WSSA+ +
Sbjct: 511 VATIKVNGTLL----DGTQVLKIYVKQTESHSILVSWKVNSNVMTSNLKWSSATMKIDNP 566
Query: 568 GATALARLPRGTHSYNITRLLQATEYWACLQVAFADAHTQLACVWARTKEA 618
T AR+P H YN+T L +T+Y CL V+ TQ +CV TK A
Sbjct: 567 HITYTARVPVDVHEYNLTHLQPSTDYEVCLTVSNIHQQTQKSCVNVTTKNA 617
>gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 638 bits (1645), Expect = 0.0
Identities = 322/633 (50%), Positives = 426/633 (67%), Gaps = 16/633 (2%)
Query: 17 TAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQTLLL 76
T V V V CP C C+IRPW+TPRS Y EA+TVDCNDL L P LPA TQ LLL
Sbjct: 17 TTLVQAVDKKVDCPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPANTQILLL 76
Query: 77 QSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHS 136
Q+N+I +++ S + NLT LDLSQN+ S + + +PQLLS++LEEN+LT L +
Sbjct: 77 QTNNIAKIEYST-DFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKC 135
Query: 137 FAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMI 196
+ L++LQELY+NHN L I+P AF GL NLLRLHLNSN L+ I+S+WF+ LPNLEILMI
Sbjct: 136 LSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMI 195
Query: 197 GGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARVPRRA 256
G N + I DMNF+PL NLRSLV+AG+NL EI D AL GL++LES+SFYDN+L +VP A
Sbjct: 196 GENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLIKVPHVA 255
Query: 257 LEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLD 316
L++V LKFLDLNKNP+ R+ GDF+NMLHLKELG+NNM EL+SID A+ NLP+L K++
Sbjct: 256 LQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNLPDLRKIE 315
Query: 317 ITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRCDCV 376
TNNPRLS+IHP AF LP++E+LMLN+NALSAL+ T+ESLPNL+E+ +H NPIRCDCV
Sbjct: 316 ATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISIHSNPIRCDCV 375
Query: 377 IRWANATGTRVRFIEPQSTLCAEPPDLQRLPVREVPFREMTDHCLPLISPRSFPPSLQVA 436
IRW N T +RF+EP S C +PP+ Q VR+V FR+M + CLPLI+P SFP +L V
Sbjct: 376 IRWMNMNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDMMEICLPLIAPESFPSNLNVE 435
Query: 437 SGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEGTLELRRVTAEEAGLYT 496
+G + HCRA AEP+PEIYW+TP+G +L P ++ V+ EGTL++ VT +E GLYT
Sbjct: 436 AGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEGTLDINGVTPKEGGLYT 495
Query: 497 CVAQNLVGADTKTVSVVVGRALLQPGRDEGQGLELRVQETHPYHILLSWVTPPNTVSTNL 556
C+A NLVGAD K+V + V + Q D L +++++ +L+SW + +++
Sbjct: 496 CIATNLVGADLKSVMIKVDGSFPQ---DNNGSLNIKIRDIQANSVLVSWKASSKILKSSV 552
Query: 557 TWSSASSLRGQGATALARLPRGTHSYNITRLLQATEYWACLQVAFADAHTQLACVWARTK 616
W++ A AR+P YN+T L +TEY C+ + + CV TK
Sbjct: 553 KWTAFVKTENSHAAQSARIPSDVKVYNLTHLNPSTEYKICIDIPTIYQKNRKKCVNVTTK 612
Query: 617 ------------EATSCHRALGDRPGLIAILAL 637
T+ LG G+I ++ L
Sbjct: 613 GLHPDQKEYEKNNTTTLMACLGGLLGIIGVICL 645
>gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 638 bits (1645), Expect = 0.0
Identities = 322/633 (50%), Positives = 426/633 (67%), Gaps = 16/633 (2%)
Query: 17 TAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQTLLL 76
T V V V CP C C+IRPW+TPRS Y EA+TVDCNDL L P LPA TQ LLL
Sbjct: 17 TTLVQAVDKKVDCPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPANTQILLL 76
Query: 77 QSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHS 136
Q+N+I +++ S + NLT LDLSQN+ S + + +PQLLS++LEEN+LT L +
Sbjct: 77 QTNNIAKIEYST-DFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKC 135
Query: 137 FAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMI 196
+ L++LQELY+NHN L I+P AF GL NLLRLHLNSN L+ I+S+WF+ LPNLEILMI
Sbjct: 136 LSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMI 195
Query: 197 GGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARVPRRA 256
G N + I DMNF+PL NLRSLV+AG+NL EI D AL GL++LES+SFYDN+L +VP A
Sbjct: 196 GENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLIKVPHVA 255
Query: 257 LEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLD 316
L++V LKFLDLNKNP+ R+ GDF+NMLHLKELG+NNM EL+SID A+ NLP+L K++
Sbjct: 256 LQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNLPDLRKIE 315
Query: 317 ITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRCDCV 376
TNNPRLS+IHP AF LP++E+LMLN+NALSAL+ T+ESLPNL+E+ +H NPIRCDCV
Sbjct: 316 ATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISIHSNPIRCDCV 375
Query: 377 IRWANATGTRVRFIEPQSTLCAEPPDLQRLPVREVPFREMTDHCLPLISPRSFPPSLQVA 436
IRW N T +RF+EP S C +PP+ Q VR+V FR+M + CLPLI+P SFP +L V
Sbjct: 376 IRWMNMNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDMMEICLPLIAPESFPSNLNVE 435
Query: 437 SGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEGTLELRRVTAEEAGLYT 496
+G + HCRA AEP+PEIYW+TP+G +L P ++ V+ EGTL++ VT +E GLYT
Sbjct: 436 AGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEGTLDINGVTPKEGGLYT 495
Query: 497 CVAQNLVGADTKTVSVVVGRALLQPGRDEGQGLELRVQETHPYHILLSWVTPPNTVSTNL 556
C+A NLVGAD K+V + V + Q D L +++++ +L+SW + +++
Sbjct: 496 CIATNLVGADLKSVMIKVDGSFPQ---DNNGSLNIKIRDIQANSVLVSWKASSKILKSSV 552
Query: 557 TWSSASSLRGQGATALARLPRGTHSYNITRLLQATEYWACLQVAFADAHTQLACVWARTK 616
W++ A AR+P YN+T L +TEY C+ + + CV TK
Sbjct: 553 KWTAFVKTENSHAAQSARIPSDVKVYNLTHLNPSTEYKICIDIPTIYQKNRKKCVNVTTK 612
Query: 617 ------------EATSCHRALGDRPGLIAILAL 637
T+ LG G+I ++ L
Sbjct: 613 GLHPDQKEYEKNNTTTLMACLGGLLGIIGVICL 645
>gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 638 bits (1645), Expect = 0.0
Identities = 322/633 (50%), Positives = 426/633 (67%), Gaps = 16/633 (2%)
Query: 17 TAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQTLLL 76
T V V V CP C C+IRPW+TPRS Y EA+TVDCNDL L P LPA TQ LLL
Sbjct: 17 TTLVQAVDKKVDCPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPANTQILLL 76
Query: 77 QSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHS 136
Q+N+I +++ S + NLT LDLSQN+ S + + +PQLLS++LEEN+LT L +
Sbjct: 77 QTNNIAKIEYST-DFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKC 135
Query: 137 FAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMI 196
+ L++LQELY+NHN L I+P AF GL NLLRLHLNSN L+ I+S+WF+ LPNLEILMI
Sbjct: 136 LSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMI 195
Query: 197 GGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARVPRRA 256
G N + I DMNF+PL NLRSLV+AG+NL EI D AL GL++LES+SFYDN+L +VP A
Sbjct: 196 GENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLIKVPHVA 255
Query: 257 LEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLD 316
L++V LKFLDLNKNP+ R+ GDF+NMLHLKELG+NNM EL+SID A+ NLP+L K++
Sbjct: 256 LQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNLPDLRKIE 315
Query: 317 ITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRCDCV 376
TNNPRLS+IHP AF LP++E+LMLN+NALSAL+ T+ESLPNL+E+ +H NPIRCDCV
Sbjct: 316 ATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISIHSNPIRCDCV 375
Query: 377 IRWANATGTRVRFIEPQSTLCAEPPDLQRLPVREVPFREMTDHCLPLISPRSFPPSLQVA 436
IRW N T +RF+EP S C +PP+ Q VR+V FR+M + CLPLI+P SFP +L V
Sbjct: 376 IRWMNMNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDMMEICLPLIAPESFPSNLNVE 435
Query: 437 SGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEGTLELRRVTAEEAGLYT 496
+G + HCRA AEP+PEIYW+TP+G +L P ++ V+ EGTL++ VT +E GLYT
Sbjct: 436 AGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEGTLDINGVTPKEGGLYT 495
Query: 497 CVAQNLVGADTKTVSVVVGRALLQPGRDEGQGLELRVQETHPYHILLSWVTPPNTVSTNL 556
C+A NLVGAD K+V + V + Q D L +++++ +L+SW + +++
Sbjct: 496 CIATNLVGADLKSVMIKVDGSFPQ---DNNGSLNIKIRDIQANSVLVSWKASSKILKSSV 552
Query: 557 TWSSASSLRGQGATALARLPRGTHSYNITRLLQATEYWACLQVAFADAHTQLACVWARTK 616
W++ A AR+P YN+T L +TEY C+ + + CV TK
Sbjct: 553 KWTAFVKTENSHAAQSARIPSDVKVYNLTHLNPSTEYKICIDIPTIYQKNRKKCVNVTTK 612
Query: 617 ------------EATSCHRALGDRPGLIAILAL 637
T+ LG G+I ++ L
Sbjct: 613 GLHPDQKEYEKNNTTTLMACLGGLLGIIGVICL 645
>gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo
sapiens]
Length = 592
Score = 185 bits (470), Expect = 1e-46
Identities = 151/513 (29%), Positives = 230/513 (44%), Gaps = 67/513 (13%)
Query: 29 CPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQSE 88
CP +C C + + V C LTAVP +PA T+ L
Sbjct: 25 CPARCECTV-----------QTRAVACTRRRLTAVPDGIPAETRLL-------------- 59
Query: 89 LGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELYL 148
+LS+N D ALP L L L EN + +E +FA L L+ L L
Sbjct: 60 ----------ELSRNRIRCLNPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRL 109
Query: 149 NHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMN 208
NQL I P F+ L NL L L+ N L + F+ L +L L +G N + +
Sbjct: 110 RGNQLKLIPPGVFTRLDNLTLLDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRA 169
Query: 209 FRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDL 268
F L L L L NL +S +L L+SL +L +A + + ++PGL L++
Sbjct: 170 FAGLLALEELTLERCNLTALSGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEI 229
Query: 269 NKNP-LQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNP------ 321
+ P L+ V G L+L L + + + ++ AL + LT L++++NP
Sbjct: 230 DNWPLLEEVAAGSLRG-LNLTSLSVTH-TNITAVPAAALRHQAHLTCLNLSHNPISTVPR 287
Query: 322 -----------------RLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEV 364
L+ + P+AF L Q+ L L+NN LS L + T S+ L+ +
Sbjct: 288 GSFRDLVRLRELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETL 347
Query: 365 GLHGNPIRCDCVIRWANATGTRVRFIEPQSTLCAEPPDLQRLPVREVPFREMTDHCL--- 421
+ GNP+ CDC + W + F + + CA P +++ +R +P + ++ +
Sbjct: 348 RVDGNPLACDCRLLWIVQRRKTLNF-DGRLPACATPAEVRGDALRNLPDSVLFEYFVCRK 406
Query: 422 PLISPRSFPPSLQVASGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEGT 481
P I R + +GE + CRA EP P + WVTP +T AGR RV P GT
Sbjct: 407 PKIRERRL-QRVTATAGEDVRFLCRAEGEPAPTVAWVTPQHRPVTATSAGRA-RVLPGGT 464
Query: 482 LELRRVTAEEAGLYTCVAQNLVGADTKTVSVVV 514
LE++ +++G YTCVA N G DT ++ V
Sbjct: 465 LEIQDARPQDSGTYTCVASNAGGNDTYFATLTV 497
>gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo
sapiens]
Length = 606
Score = 167 bits (423), Expect = 3e-41
Identities = 140/518 (27%), Positives = 224/518 (43%), Gaps = 73/518 (14%)
Query: 27 VPCPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQ 86
+ CP +C C + +V C+ L A+P +P T+ L
Sbjct: 26 IGCPARCECSA-----------QNKSVSCHRRRLIAIPEGIPIETKIL------------ 62
Query: 87 SELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQEL 146
DLS+N +F + P L + L +N + +E +F L +L+ L
Sbjct: 63 ------------DLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSL 110
Query: 147 YLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILD 206
L N+L + F+GLSNL +L ++ N + + F+ L NL+ L +G N + I
Sbjct: 111 RLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISH 170
Query: 207 MNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARVPRRALEQVPGLKFL 266
F L +L L L NL + AL L+SL SL + +P A +++ LK L
Sbjct: 171 RAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHL 230
Query: 267 DLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNP----- 321
+++ PL + P + L+L L + N L ++ A +L LT L+++ NP
Sbjct: 231 EIDYWPLLDMMPANSLYGLNLTSLSVTN-TNLSTVPFLAFKHLVYLTHLNLSYNPISTIE 289
Query: 322 ------------------RLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQE 363
+L I P +F L + L ++ N L L + S L+
Sbjct: 290 AGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEV 349
Query: 364 VGLHGNPIRCDCVIRWANATGTRVRFIEPQSTLCAEPPDLQRLPVREVPFREMTDHCLPL 423
+ ++ NP+ CDC + W ++F Q +CA P +RE F++ L
Sbjct: 350 LSINNNPLACDCRLLWILQRQPTLQF-GGQQPMCAGPD-----TIRERSFKDFHSTALSF 403
Query: 424 I----SPRSFPPSLQ---VASGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRV 476
P+ LQ V G+++ L C A +P+P I WVTP +T GR V
Sbjct: 404 YFTCKKPKIREKKLQHLLVDEGQTVQLECSADGDPQPVISWVTPRRRFITTKSNGRA-TV 462
Query: 477 YPEGTLELRRVTAEEAGLYTCVAQNLVGADTKTVSVVV 514
+GTLE+R +++G+Y C+A N G DT T S+ V
Sbjct: 463 LGDGTLEIRFAQDQDSGMYVCIASNAAGNDTFTASLTV 500
>gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens]
Length = 620
Score = 167 bits (422), Expect = 4e-41
Identities = 148/540 (27%), Positives = 235/540 (43%), Gaps = 77/540 (14%)
Query: 1 MRLLVAPLLLAW------VAGATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVD 54
+R + +PLL W V G+ + CPP+C C + V
Sbjct: 12 VRSMPSPLLACWQPILLLVLGSVLSGSATG----CPPRCECSAQD-----------RAVL 56
Query: 55 CNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFH 114
C+ AVP +P T+ L L N I ++Q E +L EL+L++N S F+
Sbjct: 57 CHRKRFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFN 116
Query: 115 ------------------------ALPQLLSLHLEENQLTRLEDHSFAGLASLQELYLNH 150
L L L + EN++ L D+ F L +L+ L +
Sbjct: 117 NLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGD 176
Query: 151 NQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFR 210
N L I+ RAFSGL++L +L L L +I + L L +L + ++AI D +F+
Sbjct: 177 NDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFK 236
Query: 211 PLANLRSLVLAGM-NLREISDYALEGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDLN 269
L L+ L ++ L ++ L GL +L SLS L VP A+ + L+FL+L+
Sbjct: 237 RLYRLKVLEISHWPYLDTMTPNCLYGL-NLTSLSITHCNLTAVPYLAVRHLVYLRFLNLS 295
Query: 270 KNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNPRLSFIHPR 329
NP+ + +MLH EL+ + + LV +L+ + P
Sbjct: 296 YNPISTIE----GSMLH----------ELLRLQEIQLV------------GGQLAVVEPY 329
Query: 330 AFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRCDCVIRWANATGTRVRF 389
AF L + L ++ N L+ L + S+ NL+ + L NP+ CDC + W R+ F
Sbjct: 330 AFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNPLACDCRLLWVFRRRWRLNF 389
Query: 390 IEPQSTLCAEPPDLQRLPVREVPFREMTDH--CLPLISPRSFPPSLQVASGESMVLHCRA 447
Q T CA P +Q ++ P + ++ C + V G ++ CRA
Sbjct: 390 NRQQPT-CATPEFVQGKEFKDFPDVLLPNYFTCRRARIRDRKAQQVFVDEGHTVQFVCRA 448
Query: 448 LAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEGTLELRRVTAEEAGLYTCVAQNLVGADT 507
+P P I W++P L A + R V+P+GTLE+R ++ G Y C+A N G D+
Sbjct: 449 DGDPPPAILWLSPR-KHLVSAKSNGRLTVFPDGTLEVRYAQVQDNGTYLCIAANAGGNDS 507
>gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo
sapiens]
Length = 593
Score = 163 bits (412), Expect = 6e-40
Identities = 149/506 (29%), Positives = 210/506 (41%), Gaps = 69/506 (13%)
Query: 29 CPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQSE 88
CP C C +P V C L AVP LP T+ L L N + + Q
Sbjct: 31 CPAVCDCTSQP-----------QAVLCGHRQLEAVPGGLPLDTELLDLSGNRLWGLQQGM 79
Query: 89 LGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELYL 148
L L+ L ELDLS N S FH L LL+L L+ N+L + F+GL++L L L
Sbjct: 80 LSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGVFSGLSALTLLDL 139
Query: 149 NHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMN 208
NQ+ AF L +L +L +G N + +
Sbjct: 140 RLNQIVLFLDGAFGELGSLQKLE------------------------VGDNHLVFVAPGA 175
Query: 209 FRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDL 268
F LA L +L L NL + AL L +L +L + + R+P AL + LK L++
Sbjct: 176 FAGLAKLSTLTLERCNLSTVPGLALARLPALVALRLRELDIGRLPAGALRGLGQLKELEI 235
Query: 269 NKNP-LQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNP------ 321
+ P L+ + PG L+L L + L S+ AL +L L LD++ NP
Sbjct: 236 HLWPSLEALDPGSLVG-LNLSSLAITRC-NLSSVPFQALYHLSFLRVLDLSQNPISAIPA 293
Query: 322 -----------------RLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEV 364
L+ I AFH L L + +NAL L + S L +
Sbjct: 294 RRLSPLVRLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLVTL 353
Query: 365 GLHGNPIRCDCVIRWANATGTRVRF-IEPQSTLCAEPPDLQRLPVREVPFREMTDH--CL 421
L GNP+ CDC + W + F + P + CA P +Q ++E H C
Sbjct: 354 RLSGNPLTCDCRLLWLLRLRRHLDFGMSPPA--CAGPHHVQGKSLKEFSDILPPGHFTCK 411
Query: 422 PLISPRSFPPSLQVASGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEGT 481
P + +S P + G V C +P P + W+ P G L AG R RV +GT
Sbjct: 412 PALIRKSGPRWVIAEEGGHAVFSCSGDGDPAPTVSWMRPHGAWL--GRAG-RVRVLEDGT 468
Query: 482 LELRRVTAEEAGLYTCVAQNLVGADT 507
LE+R V + G Y CV N+ G D+
Sbjct: 469 LEIRSVQLRDRGAYVCVVSNVAGNDS 494
>gi|76880480 hypothetical protein LOC9865 [Homo sapiens]
Length = 811
Score = 138 bits (347), Expect = 2e-32
Identities = 123/406 (30%), Positives = 170/406 (41%), Gaps = 27/406 (6%)
Query: 9 LLAWVAGATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPAL- 67
LL V G A P+ CP +C CQ + C + L VP
Sbjct: 9 LLLVVCGCLALPPLA--EPVCPERCDCQ------------HPQHLLCTNRGLRVVPKTSS 54
Query: 68 ---PAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHL 124
P T L N I + + L L LDL N F L +L L+L
Sbjct: 55 LPSPHDVLTYSLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYL 114
Query: 125 EENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRW 184
N L L + A L L+ LY N N++ R++ +F GL +L++L L+ N L A+
Sbjct: 115 GNNLLQALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAV 174
Query: 185 FEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYA--LEGLQSLESL 242
F L NL L + N++ + F L LR L L+ L+ +A L+SL SL
Sbjct: 175 FAPLGNLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSL 234
Query: 243 SFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSID 302
N L + R + +P L L L N L + P F + L+EL L L +
Sbjct: 235 ILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEG-NRLSQLP 293
Query: 303 KFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQ 362
L L L LD++ N LS +HP F HL ++ L L NNALSAL + P L
Sbjct: 294 TALLEPLHSLEALDLSGN-ELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPALY 352
Query: 363 EVGLHGNPIRCDCVI----RWANATGTRVRFIEPQSTLCAEPPDLQ 404
+ L GN CDC + RW ++ R + C PP L+
Sbjct: 353 RLDLDGNGWTCDCRLRGLKRWMGDWHSQGRLL-TVFVQCRHPPALR 397
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 134 bits (337), Expect = 3e-31
Identities = 111/368 (30%), Positives = 163/368 (44%), Gaps = 38/368 (10%)
Query: 29 CPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQSE 88
CP +C C A+ V+C + AVP LP +L + + I +++S
Sbjct: 31 CPSECTCS------------RASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESP 78
Query: 89 LGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELYL 148
++ L L + +N S F L L L L N+L L F GL SL+ L L
Sbjct: 79 FLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLL 138
Query: 149 NHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMN 208
+ NQL +I P FS SNL L L+ N L I F+ L L L +G N + I
Sbjct: 139 SSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRV 198
Query: 209 FRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQ-------------------- 248
F+ L NL+ L L L +I +GL +L+ L+ NQ
Sbjct: 199 FQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYL 258
Query: 249 ----LARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKF 304
++++P Q+P L L L N L+ + G F M +L+EL L + + S+
Sbjct: 259 SNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYD-NHISSLPDN 317
Query: 305 ALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEV 364
NL +L L ++ N ++SFI P AF+ L ++ L L+ NAL L L NLQ +
Sbjct: 318 VFSNLRQLQVLILSRN-QISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNI 376
Query: 365 GLHGNPIR 372
L N +R
Sbjct: 377 SLQNNRLR 384
Score = 125 bits (315), Expect = 1e-28
Identities = 91/303 (30%), Positives = 138/303 (45%), Gaps = 2/303 (0%)
Query: 72 QTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTR 131
++LLL SN ++++ + +NL EL L N D F L L L+L +N LT
Sbjct: 134 ESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTH 193
Query: 132 LEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNL 191
+ F L +LQ L L N+L I F GL NL L L N + + F NL
Sbjct: 194 ISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNL 253
Query: 192 EILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLAR 251
+ L + N + + F L L L L G +L+E+S + +L L YDN ++
Sbjct: 254 QRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISS 313
Query: 252 VPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPE 311
+P + L+ L L++N + + PG F + L+EL L+ L +D L
Sbjct: 314 LPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHT-NALQDLDGNVFRMLAN 372
Query: 312 LTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPI 371
L + + NN RL + F ++ + + L NN L L + L L E+ L+ NP
Sbjct: 373 LQNISLQNN-RLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPW 431
Query: 372 RCD 374
RCD
Sbjct: 432 RCD 434
Score = 98.2 bits (243), Expect = 2e-20
Identities = 74/252 (29%), Positives = 117/252 (46%), Gaps = 1/252 (0%)
Query: 70 GTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQL 129
G L L NS+ + +L NL L L +N +D F L L L L++NQ+
Sbjct: 180 GLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQI 239
Query: 130 TRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLP 189
L F +LQ LYL++N + ++ P F L L RL L N L+ + F +P
Sbjct: 240 GLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMP 299
Query: 190 NLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQL 249
NL L + N + ++ D F L L+ L+L+ + IS A GL L LS + N L
Sbjct: 300 NLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNAL 359
Query: 250 ARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNL 309
+ + L+ + L N L+++ FAN+ L + L N +L ++ +L
Sbjct: 360 QDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQN-NQLENLPLGIFDHL 418
Query: 310 PELTKLDITNNP 321
+L +L + +NP
Sbjct: 419 GKLCELRLYDNP 430
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 134 bits (337), Expect = 3e-31
Identities = 111/368 (30%), Positives = 163/368 (44%), Gaps = 38/368 (10%)
Query: 29 CPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQSE 88
CP +C C A+ V+C + AVP LP +L + + I +++S
Sbjct: 25 CPSECTCS------------RASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESP 72
Query: 89 LGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELYL 148
++ L L + +N S F L L L L N+L L F GL SL+ L L
Sbjct: 73 FLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLL 132
Query: 149 NHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMN 208
+ NQL +I P FS SNL L L+ N L I F+ L L L +G N + I
Sbjct: 133 SSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRV 192
Query: 209 FRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQ-------------------- 248
F+ L NL+ L L L +I +GL +L+ L+ NQ
Sbjct: 193 FQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYL 252
Query: 249 ----LARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKF 304
++++P Q+P L L L N L+ + G F M +L+EL L + + S+
Sbjct: 253 SNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYD-NHISSLPDN 311
Query: 305 ALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEV 364
NL +L L ++ N ++SFI P AF+ L ++ L L+ NAL L L NLQ +
Sbjct: 312 VFSNLRQLQVLILSRN-QISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNI 370
Query: 365 GLHGNPIR 372
L N +R
Sbjct: 371 SLQNNRLR 378
Score = 125 bits (315), Expect = 1e-28
Identities = 91/303 (30%), Positives = 138/303 (45%), Gaps = 2/303 (0%)
Query: 72 QTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTR 131
++LLL SN ++++ + +NL EL L N D F L L L+L +N LT
Sbjct: 128 ESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTH 187
Query: 132 LEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNL 191
+ F L +LQ L L N+L I F GL NL L L N + + F NL
Sbjct: 188 ISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNL 247
Query: 192 EILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLAR 251
+ L + N + + F L L L L G +L+E+S + +L L YDN ++
Sbjct: 248 QRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISS 307
Query: 252 VPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPE 311
+P + L+ L L++N + + PG F + L+EL L+ L +D L
Sbjct: 308 LPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHT-NALQDLDGNVFRMLAN 366
Query: 312 LTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPI 371
L + + NN RL + F ++ + + L NN L L + L L E+ L+ NP
Sbjct: 367 LQNISLQNN-RLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPW 425
Query: 372 RCD 374
RCD
Sbjct: 426 RCD 428
Score = 98.2 bits (243), Expect = 2e-20
Identities = 74/252 (29%), Positives = 117/252 (46%), Gaps = 1/252 (0%)
Query: 70 GTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQL 129
G L L NS+ + +L NL L L +N +D F L L L L++NQ+
Sbjct: 174 GLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQI 233
Query: 130 TRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLP 189
L F +LQ LYL++N + ++ P F L L RL L N L+ + F +P
Sbjct: 234 GLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMP 293
Query: 190 NLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQL 249
NL L + N + ++ D F L L+ L+L+ + IS A GL L LS + N L
Sbjct: 294 NLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNAL 353
Query: 250 ARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNL 309
+ + L+ + L N L+++ FAN+ L + L N +L ++ +L
Sbjct: 354 QDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQN-NQLENLPLGIFDHL 412
Query: 310 PELTKLDITNNP 321
+L +L + +NP
Sbjct: 413 GKLCELRLYDNP 424
>gi|31542244 leucine rich repeat and fibronectin type III domain
containing 5 [Homo sapiens]
Length = 719
Score = 132 bits (332), Expect = 1e-30
Identities = 109/393 (27%), Positives = 170/393 (43%), Gaps = 74/393 (18%)
Query: 120 LSLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRA 179
+ L L +N +T ++ FA + SL +L L+ N + I P AF+ L NL LHLNSN L
Sbjct: 54 VELRLADNFVTNIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTK 113
Query: 180 IDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSL 239
I + DM F L+NL L+L L IS A + + +L
Sbjct: 114 ITN-----------------------DM-FSGLSNLHHLILNNNQLTLISSTAFDDVFAL 149
Query: 240 ESLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELV 299
E L N L +P A+E++ L L L+ N + + G F+
Sbjct: 150 EELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIPKGTFS----------------- 192
Query: 300 SIDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLP 359
+L ++T+LD+T+N +L + P L Q ++ + +S P
Sbjct: 193 --------HLHKMTRLDVTSN-KLQKLPP---DPLFQRAQVLATSGIIS----------P 230
Query: 360 NLQEVGLHGNPIRCDCVIRWANATGTRVRFIEPQSTLCAEPPDLQRLPVREVPFREMTDH 419
+ + GNP+ C+C + W E CA PP L +P E
Sbjct: 231 STFALSFGGNPLHCNCELLWLRRLSR-----EDDLETCASPPLLTGRYFWSIPEEEFL-- 283
Query: 420 CLPLISPRSFPPSLQVASGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPE 479
C P + R ++V G+ L C+A +PEP I+W++P G ++ A R VY
Sbjct: 284 CEPPLITR-HTHEMRVLEGQRATLRCKARGDPEPAIHWISPEGKLISNA---TRSLVYDN 339
Query: 480 GTLELRRVTAEEAGLYTCVAQNLVGADTKTVSV 512
GTL++ T ++ G +TC+A N G T+ V +
Sbjct: 340 GTLDILITTVKDTGAFTCIASNPAGEATQIVDL 372
Score = 84.7 bits (208), Expect = 3e-16
Identities = 62/200 (31%), Positives = 94/200 (47%), Gaps = 9/200 (4%)
Query: 29 CPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQSE 88
CP +C CQI S AT C L VPP + T L L N + + + +
Sbjct: 20 CPKRCVCQIL-------SPNLATL--CAKKGLLFVPPNIDRRTVELRLADNFVTNIKRKD 70
Query: 89 LGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELYL 148
+ +L +L LS+N+ S F L L +LHL N+LT++ + F+GL++L L L
Sbjct: 71 FANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLSNLHHLIL 130
Query: 149 NHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMN 208
N+NQL I+ AF + L L L+ N L I E + +L L + N +D I
Sbjct: 131 NNNQLTLISSTAFDDVFALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIPKGT 190
Query: 209 FRPLANLRSLVLAGMNLREI 228
F L + L + L+++
Sbjct: 191 FSHLHKMTRLDVTSNKLQKL 210
>gi|225579152 insulin-like growth factor binding protein, acid
labile subunit isoform 1 precursor [Homo sapiens]
Length = 643
Score = 130 bits (326), Expect = 6e-30
Identities = 112/377 (29%), Positives = 169/377 (44%), Gaps = 16/377 (4%)
Query: 3 LLVAPLLLAWVA-------GATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDC 55
L +A LLL+WVA GA P CP C C + +V C
Sbjct: 46 LALALLLLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSY-------DDDADELSVFC 98
Query: 56 NDLFLTAVPPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHA 115
+ LT +P +P GTQ L L N++ V + L++L L+L
Sbjct: 99 SSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLG 158
Query: 116 LPQLLSLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSN 175
L L LHLE NQL L +FA +L L L++N+L R+ F GL +L L+L N
Sbjct: 159 LENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWN 218
Query: 176 LLRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEG 235
L + F L +L L++ GN++ + F LA LR L L+ LR I
Sbjct: 219 SLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQ 278
Query: 236 LQSLESLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNM 295
L L+ L N +A V A + L++LDL+ N + + F +L L+ L L++
Sbjct: 279 LPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSH- 337
Query: 296 EELVSIDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTV 355
+ S+ +L L +L + +N R+ + R+F L Q+E L L++N L +
Sbjct: 338 NAIASLRPRTFKDLHFLEELQLGHN-RIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAF 396
Query: 356 ESLPNLQEVGLHGNPIR 372
L N+ + L GN +R
Sbjct: 397 LGLTNVAVMNLSGNCLR 413
Score = 124 bits (311), Expect = 3e-28
Identities = 104/360 (28%), Positives = 177/360 (49%), Gaps = 12/360 (3%)
Query: 74 LLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLE 133
L+L N + + + LA L ELDLS+N+ + F LP+L L+L+ N + +
Sbjct: 237 LVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVA 296
Query: 134 DHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEI 193
+F GL +L+ L L+HN++ + F GL L L L+ N + ++ R F+ L LE
Sbjct: 297 PGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEE 356
Query: 194 LMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARVP 253
L +G N++ + + +F L L L L L+E+ A GL ++ ++ N L +P
Sbjct: 357 LQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLP 416
Query: 254 RRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELT 313
+ + L L L + L R+ P F + L+ L L + LV I++ +L L EL
Sbjct: 417 EQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKD-NGLVGIEEQSLWGLAELL 475
Query: 314 KLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRC 373
+LD+T+N +L+ + R F L ++E L+L+ N L+ L + L + + N R
Sbjct: 476 ELDLTSN-QLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHN--RL 532
Query: 374 DCVIRWANATGTRVRFIEPQS----TLCAEPPDLQRLPVREVPFREMTDHCLPLISPRSF 429
+ + A R+R++ ++ T +PP L+RL + P+ D PL + R F
Sbjct: 533 EALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPW----DCGCPLKALRDF 588
Score = 113 bits (283), Expect = 5e-25
Identities = 105/359 (29%), Positives = 157/359 (43%), Gaps = 25/359 (6%)
Query: 72 QTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTR 131
Q L L N I V L L LDLS N + + F L L L L N +
Sbjct: 283 QKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIAS 342
Query: 132 LEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNL 191
L +F L L+EL L HN++ ++A R+F GL L L L+ N L+ + + F L N+
Sbjct: 343 LRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNV 402
Query: 192 EILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLAR 251
++ + GN + + + FR L L SL L G L I + GL L L DN L
Sbjct: 403 AVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVG 462
Query: 252 VPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPE 311
+ ++L + L LDL N L + F + L+ L L + L + AL L
Sbjct: 463 IEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYL-LLSRNRLAELPADALGPLQR 521
Query: 312 LTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPI 371
LD+++N RL + L ++ L L NN+L Q P L+ + L GNP
Sbjct: 522 AFWLDVSHN-RLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQP----PGLERLWLEGNPW 576
Query: 372 RCDCVIR----WANATGTRV-RFIEP--------------QSTLCAEPPDLQRLPVREV 411
C C ++ +A + V RF++ + CA PP++ L +R++
Sbjct: 577 DCGCPLKALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASPPEVVGLDLRDL 635
Score = 86.3 bits (212), Expect = 9e-17
Identities = 76/262 (29%), Positives = 114/262 (43%), Gaps = 27/262 (10%)
Query: 60 LTAVPPALPAGTQTLL---LQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHAL 116
+ AV P G + L L N + + + L L L LS N+ + R F L
Sbjct: 292 IAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDL 351
Query: 117 PQLLSLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNL 176
L L L N++ +L + SF GL L+ L L+HNQL + AF GL+N+ ++L+ N
Sbjct: 352 HFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNC 411
Query: 177 LRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYAL--- 233
LR + + F L L L + G+ + I F L+ LR L L L I + +L
Sbjct: 412 LRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGL 471
Query: 234 ---------------------EGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDLNKNP 272
+GL LE L N+LA +P AL + +LD++ N
Sbjct: 472 AELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNR 531
Query: 273 LQRVGPGDFANMLHLKELGLNN 294
L+ + A + L+ L L N
Sbjct: 532 LEALPNSLLAPLGRLRYLSLRN 553
Score = 53.1 bits (126), Expect = 9e-07
Identities = 41/134 (30%), Positives = 61/134 (45%), Gaps = 4/134 (2%)
Query: 69 AGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQ 128
+G + L L+ N +V +++ L LA L ELDL+ N + F L +L L L N+
Sbjct: 448 SGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNR 507
Query: 129 LTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEML 188
L L + L L ++HN+L + + L L L L +N LR +
Sbjct: 508 LAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQ----P 563
Query: 189 PNLEILMIGGNKVD 202
P LE L + GN D
Sbjct: 564 PGLERLWLEGNPWD 577
>gi|4826772 insulin-like growth factor binding protein, acid labile
subunit isoform 2 precursor [Homo sapiens]
Length = 605
Score = 130 bits (326), Expect = 6e-30
Identities = 112/377 (29%), Positives = 169/377 (44%), Gaps = 16/377 (4%)
Query: 3 LLVAPLLLAWVA-------GATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDC 55
L +A LLL+WVA GA P CP C C + +V C
Sbjct: 8 LALALLLLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSY-------DDDADELSVFC 60
Query: 56 NDLFLTAVPPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHA 115
+ LT +P +P GTQ L L N++ V + L++L L+L
Sbjct: 61 SSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLG 120
Query: 116 LPQLLSLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSN 175
L L LHLE NQL L +FA +L L L++N+L R+ F GL +L L+L N
Sbjct: 121 LENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWN 180
Query: 176 LLRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEG 235
L + F L +L L++ GN++ + F LA LR L L+ LR I
Sbjct: 181 SLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQ 240
Query: 236 LQSLESLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNM 295
L L+ L N +A V A + L++LDL+ N + + F +L L+ L L++
Sbjct: 241 LPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSH- 299
Query: 296 EELVSIDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTV 355
+ S+ +L L +L + +N R+ + R+F L Q+E L L++N L +
Sbjct: 300 NAIASLRPRTFKDLHFLEELQLGHN-RIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAF 358
Query: 356 ESLPNLQEVGLHGNPIR 372
L N+ + L GN +R
Sbjct: 359 LGLTNVAVMNLSGNCLR 375
Score = 124 bits (311), Expect = 3e-28
Identities = 104/360 (28%), Positives = 177/360 (49%), Gaps = 12/360 (3%)
Query: 74 LLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLE 133
L+L N + + + LA L ELDLS+N+ + F LP+L L+L+ N + +
Sbjct: 199 LVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVA 258
Query: 134 DHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEI 193
+F GL +L+ L L+HN++ + F GL L L L+ N + ++ R F+ L LE
Sbjct: 259 PGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEE 318
Query: 194 LMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARVP 253
L +G N++ + + +F L L L L L+E+ A GL ++ ++ N L +P
Sbjct: 319 LQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLP 378
Query: 254 RRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELT 313
+ + L L L + L R+ P F + L+ L L + LV I++ +L L EL
Sbjct: 379 EQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKD-NGLVGIEEQSLWGLAELL 437
Query: 314 KLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRC 373
+LD+T+N +L+ + R F L ++E L+L+ N L+ L + L + + N R
Sbjct: 438 ELDLTSN-QLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHN--RL 494
Query: 374 DCVIRWANATGTRVRFIEPQS----TLCAEPPDLQRLPVREVPFREMTDHCLPLISPRSF 429
+ + A R+R++ ++ T +PP L+RL + P+ D PL + R F
Sbjct: 495 EALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPW----DCGCPLKALRDF 550
Score = 113 bits (283), Expect = 5e-25
Identities = 105/359 (29%), Positives = 157/359 (43%), Gaps = 25/359 (6%)
Query: 72 QTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTR 131
Q L L N I V L L LDLS N + + F L L L L N +
Sbjct: 245 QKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIAS 304
Query: 132 LEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNL 191
L +F L L+EL L HN++ ++A R+F GL L L L+ N L+ + + F L N+
Sbjct: 305 LRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNV 364
Query: 192 EILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLAR 251
++ + GN + + + FR L L SL L G L I + GL L L DN L
Sbjct: 365 AVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVG 424
Query: 252 VPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPE 311
+ ++L + L LDL N L + F + L+ L L + L + AL L
Sbjct: 425 IEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYL-LLSRNRLAELPADALGPLQR 483
Query: 312 LTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPI 371
LD+++N RL + L ++ L L NN+L Q P L+ + L GNP
Sbjct: 484 AFWLDVSHN-RLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQP----PGLERLWLEGNPW 538
Query: 372 RCDCVIR----WANATGTRV-RFIEP--------------QSTLCAEPPDLQRLPVREV 411
C C ++ +A + V RF++ + CA PP++ L +R++
Sbjct: 539 DCGCPLKALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASPPEVVGLDLRDL 597
Score = 86.3 bits (212), Expect = 9e-17
Identities = 76/262 (29%), Positives = 114/262 (43%), Gaps = 27/262 (10%)
Query: 60 LTAVPPALPAGTQTLL---LQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHAL 116
+ AV P G + L L N + + + L L L LS N+ + R F L
Sbjct: 254 IAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDL 313
Query: 117 PQLLSLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNL 176
L L L N++ +L + SF GL L+ L L+HNQL + AF GL+N+ ++L+ N
Sbjct: 314 HFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNC 373
Query: 177 LRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYAL--- 233
LR + + F L L L + G+ + I F L+ LR L L L I + +L
Sbjct: 374 LRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGL 433
Query: 234 ---------------------EGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDLNKNP 272
+GL LE L N+LA +P AL + +LD++ N
Sbjct: 434 AELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNR 493
Query: 273 LQRVGPGDFANMLHLKELGLNN 294
L+ + A + L+ L L N
Sbjct: 494 LEALPNSLLAPLGRLRYLSLRN 515
Score = 53.1 bits (126), Expect = 9e-07
Identities = 41/134 (30%), Positives = 61/134 (45%), Gaps = 4/134 (2%)
Query: 69 AGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQ 128
+G + L L+ N +V +++ L LA L ELDL+ N + F L +L L L N+
Sbjct: 410 SGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNR 469
Query: 129 LTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEML 188
L L + L L ++HN+L + + L L L L +N LR +
Sbjct: 470 LAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQ----P 525
Query: 189 PNLEILMIGGNKVD 202
P LE L + GN D
Sbjct: 526 PGLERLWLEGNPWD 539
>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
Length = 545
Score = 128 bits (322), Expect = 2e-29
Identities = 111/429 (25%), Positives = 177/429 (41%), Gaps = 70/429 (16%)
Query: 28 PCPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQS 87
PCP C C ++ V C+D L VP +P T+ ++ S ++
Sbjct: 21 PCPMGCDCFVQE-------------VFCSDEELATVPLDIPPYTKNIIFVETSFTTLETR 67
Query: 88 ELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELY 147
G NLT++ R F LP+L L + + L + F+ L SL +L
Sbjct: 68 AFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLT 127
Query: 148 LNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDM 207
LN N L + F L+ L LHL N L+A+ R F+ L +L+ L + N + + +
Sbjct: 128 LNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEE 187
Query: 208 NFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARVPRRALEQV------- 260
F PL +L++L L+ L + L SL+ L N ++ +P + Q+
Sbjct: 188 LFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLW 247
Query: 261 -----------------------------------------PGLKFLDLNKNPLQRVGPG 279
P L L L N L+ V G
Sbjct: 248 LQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEG 307
Query: 280 DFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMET 339
FA++ +L+ L L+ + + +L EL KL + +N L+ +HP F +L ++E
Sbjct: 308 TFAHLSNLRSLMLS-YNAITHLPAGIFRDLEELVKLYLGSN-NLTALHPALFQNLSKLEL 365
Query: 340 LMLNNNALSALHQQTVESLPNLQEVGLHGNPIRCDC----VIRWANATGTRVRFIEPQST 395
L L+ N L+ L + ++ NL + LHGNP +CDC + W R+ I+ T
Sbjct: 366 LSLSKNQLTTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQYTDRLLNIQ---T 422
Query: 396 LCAEPPDLQ 404
CA P L+
Sbjct: 423 YCAGPAYLK 431
>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
[Homo sapiens]
Length = 1093
Score = 128 bits (322), Expect = 2e-29
Identities = 145/588 (24%), Positives = 234/588 (39%), Gaps = 105/588 (17%)
Query: 3 LLVAPLLLAWVAGATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFLTA 62
LL+ LLL + TAA PC C C ++DC L A
Sbjct: 18 LLLLWLLLLRLEPVTAAAGP---RAPCAAACTCA-------------GDSLDCGGRGLAA 61
Query: 63 VPPALPAGTQ-----------------------------------------------TLL 75
+P LP+ T+ +L
Sbjct: 62 LPGDLPSWTRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAASSHVVSLF 121
Query: 76 LQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDH 135
LQ N I V+ S+L +L LDLS N+ ++ R+ F P + L+L N++ LE
Sbjct: 122 LQHNKIRSVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELG 181
Query: 136 SFAGLA-SLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEIL 194
+F GL+ SL L L+ N++ ++ RAF L L +L LN N +R I+ F+ L +LE+L
Sbjct: 182 AFDGLSRSLLTLRLSKNRITQLPVRAFK-LPRLTQLDLNRNRIRLIEGLTFQGLNSLEVL 240
Query: 195 MIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARVPR 254
+ N + + D F L+ + L L +L E++ +L GL +L L +N +AR+ R
Sbjct: 241 KLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHR 300
Query: 255 R------------------------ALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKEL 290
+ +L ++ L L L+ N + + G F + L+ L
Sbjct: 301 KGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVL 360
Query: 291 GLNNMEELVSID--KFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALS 348
L++ E +I+ A L L+KL + N ++ + RAF L +E L L NA+
Sbjct: 361 DLDHNEISGTIEDTSGAFSGLDSLSKLTLFGN-KIKSVAKRAFSGLEGLEHLNLGGNAIR 419
Query: 349 ALHQQTVESLPNLQEVGLHGNPIRCDCVIRWANATGTRVRFIEPQSTLCAEPPDLQRLPV 408
++ + NL+E+ + + CDC ++W + CA P L+ +
Sbjct: 420 SVQFDAFVKMKNLKELHISSDSFLCDCQLKWLPPWLIGRMLQAFVTATCAHPESLKGQSI 479
Query: 409 REVPFREMTDHCLPLISPR--SFPPSLQVASGESMVLHCRAL-AEPEPEIYWVTPAGLRL 465
VP C + P+ + P + G+ + C A + P + L
Sbjct: 480 FSVPPESFV--CDDFLKPQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVL 537
Query: 466 TPAHAGRRYRVYPEG--------TLELRRVTAEEAGLYTCVAQNLVGA 505
T A V+ + L LR+VT G Y CV N G+
Sbjct: 538 TNADMENFVHVHAQDGEVMEYTTILHLRQVTFGHEGRYQCVITNHFGS 585
Score = 43.9 bits (102), Expect = 5e-04
Identities = 26/73 (35%), Positives = 38/73 (52%), Gaps = 5/73 (6%)
Query: 435 VASGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEG-TLELRRVTAEEAG 493
V+ GE++ L C+A P P I W G R P R+ + P+ L ++ V AE+AG
Sbjct: 704 VSVGETVALQCKATGNPPPRITWF--KGDR--PLSLTERHHLTPDNQLLVVQNVVAEDAG 759
Query: 494 LYTCVAQNLVGAD 506
YTC N +G +
Sbjct: 760 RYTCEMSNTLGTE 772
Score = 42.7 bits (99), Expect = 0.001
Identities = 25/86 (29%), Positives = 40/86 (46%), Gaps = 2/86 (2%)
Query: 430 PPSLQVASGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEGTLE-LRRVT 488
P + + + L C A P P+I W G PA RR V P+ + + V
Sbjct: 605 PHDITIRTTTMARLECAATGHPNPQIAWQKDGGTDF-PAARERRMHVMPDDDVFFITDVK 663
Query: 489 AEEAGLYTCVAQNLVGADTKTVSVVV 514
++AG+Y+C AQN G+ + ++ V
Sbjct: 664 IDDAGVYSCTAQNSAGSISANATLTV 689
>gi|198041768 synleurin [Homo sapiens]
Length = 622
Score = 128 bits (321), Expect = 2e-29
Identities = 106/364 (29%), Positives = 174/364 (47%), Gaps = 13/364 (3%)
Query: 53 VDCNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCD 112
++C +L L+++P P T L L N+I +++SEL L +L L L ++
Sbjct: 44 INCRNLGLSSIPKNFPESTVFLYLTGNNISYINESELTGLHSLVALYLDNSNILYVYPKA 103
Query: 113 FHALPQLLSLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHL 172
F L L L L N + RL+ F GL +L+ LYL +NQ+ + F+ L ++ L+L
Sbjct: 104 FVQLRHLYFLFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNL 163
Query: 173 NSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYA 232
N L + S F + L IL + N + I + F+ L NL L L NL ++ A
Sbjct: 164 QRNRLTVLGSGTFVGMVALRILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNA 223
Query: 233 LEGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGL 292
E L+SL LS N + + A + + L++L L + ++ V F+ + +LK L L
Sbjct: 224 FEVLKSLRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLIL 283
Query: 293 --NNMEELVSIDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSAL 350
N++E L S D F+L L L L + N +S + + ++ L L+ N L+AL
Sbjct: 284 SHNDLENLNS-DTFSL--LKNLIYLKLDRNRIISIDNDTFENMGASLKILNLSFNNLTAL 340
Query: 351 HQQTVESLPNLQEVGLHGNPIRCDCVIRWANATGTRVRFIEPQSTL---CAEPPDLQRLP 407
H + ++ L +L + + NP C+C + G R TL C PP ++
Sbjct: 341 HPRVLKPLSSLIHLQANSNPWECNCKL-----LGLRDWLASSAITLNIYCQNPPSMRGRA 395
Query: 408 VREV 411
+R +
Sbjct: 396 LRYI 399
>gi|27363458 leucine rich repeat and fibronectin type III domain
containing 4 [Homo sapiens]
Length = 635
Score = 126 bits (317), Expect = 6e-29
Identities = 148/557 (26%), Positives = 224/557 (40%), Gaps = 93/557 (16%)
Query: 145 ELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAI 204
EL L N + + P F ++ L+ L L+ N + I +R F L +L L + GN++ +
Sbjct: 52 ELRLADNFIQALGPPDFRNMTGLVDLTLSRNAITRIGARAFGDLESLRSLHLDGNRLVEL 111
Query: 205 LDMNFRPLANLRSLVLAGMNLREISDYALEG-LQSLESLSFYDNQLARVPRRALEQVPGL 263
+ R NL+ L+L+G L I+ A + L+SLE L N L +VP + +P L
Sbjct: 112 GTGSLRGPVNLQHLILSGNQLGRIAPGAFDDFLESLEDLDLSYNNLRQVPWAGIGAMPAL 171
Query: 264 KFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNPRL 323
L+L+ N + + PG FA L +L++LD+T+N RL
Sbjct: 172 HTLNLDHNLIDALPPGAFA-------------------------QLGQLSRLDLTSN-RL 205
Query: 324 SFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRCDCVIRWANAT 383
+ + P + E+ P + GNP+ C+C + W
Sbjct: 206 ATLAPDPLFS-----------------RGRDAEASPAPLVLSFSGNPLHCNCELLWLR-- 246
Query: 384 GTRVRFIEPQS-TLCAEPPDLQRLPVREVPFREMTDHCLPLISPRSFPPSLQVASGESMV 442
R P CA PP L VP E + C P + R L V G+
Sbjct: 247 ----RLARPDDLETCASPPGLAGRYFWAVPEGEFS--CEPPLIAR-HTQRLWVLEGQRAT 299
Query: 443 LHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEGTLELRRVTAEEAGLYTCVAQNL 502
L CRAL +P P ++WV P RL + R R +P GTLE+ A +AG YTC+A N
Sbjct: 300 LRCRALGDPAPTMHWVGPDD-RLVGNSS--RARAFPNGTLEIGVTGAGDAGGYTCIATNP 356
Query: 503 VGADTKTVSVVV------GRALLQPGRD-------------EGQGL-----ELRVQETHP 538
G T V + V G + + GR EG+G ++V E
Sbjct: 357 AGEATARVELRVLALPHGGNSSAEGGRPGPSDIAASARTAAEGEGTLESEPAVQVTEVTA 416
Query: 539 YHILLSWVTPPNTVSTNLTWSSASSLRGQGATALARL-PRGTHSYNITRLLQATEYWACL 597
L+SW P + + + T + R+ P +H + + L+ +Y CL
Sbjct: 417 TSGLVSW--GPGRPADPVWMFQIQYNSSEDETLIYRIVPASSHHFLLKHLVPGADYDLCL 474
Query: 598 QV-------AFADAHTQLACVWARTKEATS-CHRALGDRPGLIAILALAVLLLAAGLAAH 649
+ A L C T A+ CH G +A+ +L+AA L
Sbjct: 475 LALSPAAGPSDLTATRLLGCAHFSTLPASPLCHALQAHVLGGTLTVAVGGVLVAALLVFT 534
Query: 650 LGTGQPRKGVG-GRRPL 665
+ +G G GR PL
Sbjct: 535 VALLVRGRGAGNGRLPL 551
Score = 83.2 bits (204), Expect = 8e-16
Identities = 72/227 (31%), Positives = 98/227 (43%), Gaps = 19/227 (8%)
Query: 4 LVAPLLLAWVAGATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAV 63
+ PLLL +A AA CP C CQ + E+ + C L V
Sbjct: 1 MAPPLLLLLLASGAAA---------CPLPCVCQ---------NLSESLSTLCAHRGLLFV 42
Query: 64 PPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLH 123
PP + T L L N I + + + L +L LS+N+ + F L L SLH
Sbjct: 43 PPNVDRRTVELRLADNFIQALGPPDFRNMTGLVDLTLSRNAITRIGARAFGDLESLRSLH 102
Query: 124 LEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSG-LSNLLRLHLNSNLLRAIDS 182
L+ N+L L S G +LQ L L+ NQL RIAP AF L +L L L+ N LR +
Sbjct: 103 LDGNRLVELGTGSLRGPVNLQHLILSGNQLGRIAPGAFDDFLESLEDLDLSYNNLRQVPW 162
Query: 183 RWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREIS 229
+P L L + N +DA+ F L L L L L ++
Sbjct: 163 AGIGAMPALHTLNLDHNLIDALPPGAFAQLGQLSRLDLTSNRLATLA 209
Score = 47.8 bits (112), Expect = 4e-05
Identities = 30/92 (32%), Positives = 45/92 (48%), Gaps = 1/92 (1%)
Query: 68 PAGTQTLLLQSNSIVRVDQSELG-YLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEE 126
P Q L+L N + R+ +L +L +LDLS N+ A+P L +L+L+
Sbjct: 119 PVNLQHLILSGNQLGRIAPGAFDDFLESLEDLDLSYNNLRQVPWAGIGAMPALHTLNLDH 178
Query: 127 NQLTRLEDHSFAGLASLQELYLNHNQLYRIAP 158
N + L +FA L L L L N+L +AP
Sbjct: 179 NLIDALPPGAFAQLGQLSRLDLTSNRLATLAP 210
>gi|13375646 leucine rich repeat and fibronectin type III domain
containing 3 [Homo sapiens]
Length = 628
Score = 124 bits (312), Expect = 2e-28
Identities = 109/373 (29%), Positives = 162/373 (43%), Gaps = 53/373 (14%)
Query: 145 ELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAI 204
EL L N + + R + ++ LL L L+ N +R + + F L L L + GN++ ++
Sbjct: 63 ELRLADNFIASVRRRDLANMTGLLHLSLSRNTIRHVAAGAFADLRALRALHLDGNRLTSL 122
Query: 205 LDMNFRPLANLRSLVLAGMNLREISDYALEGL-QSLESLSFYDNQLARVPRRALEQVPGL 263
+ R L NLR L+L+ L ++ AL+ ++LE L N L ++P AL ++ +
Sbjct: 123 GEGQLRGLVNLRHLILSNNQLAALAAGALDDCAETLEDLDLSYNNLEQLPWEALGRLGNV 182
Query: 264 KFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNPRL 323
L L+ N L V G F+ L +L +LD+T+N RL
Sbjct: 183 NTLGLDHNLLASVPAGAFSR-------------------------LHKLARLDMTSN-RL 216
Query: 324 SFIHPRA-FHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRCDCVIRWANA 382
+ I P F LP + + SAL + GNP+ C+C + W
Sbjct: 217 TTIPPDPLFSRLPLLARP--RGSPASAL------------VLAFGGNPLHCNCELVWLRR 262
Query: 383 TGTRVRFIEPQSTLCAEPPDLQRLPVREVPFREMTDHCLPLISPRSFPPSLQVASGESMV 442
E CA PP L V E C P + PP L V +G
Sbjct: 263 LAR-----EDDLEACASPPALGGRYFWAVGEEEFV--CEPPVVTHRSPP-LAVPAGRPAA 314
Query: 443 LHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEGTLELRRVTAEEAGLYTCVAQNL 502
L CRA+ +PEP + WV+P G L + R R +P GTLEL + G++TC+A N
Sbjct: 315 LRCRAVGDPEPRVRWVSPQGRLLGNSS---RARAFPNGTLELLVTEPGDGGIFTCIAANA 371
Query: 503 VGADTKTVSVVVG 515
G T V + VG
Sbjct: 372 AGEATAAVELTVG 384
Score = 72.0 bits (175), Expect = 2e-12
Identities = 67/230 (29%), Positives = 98/230 (42%), Gaps = 15/230 (6%)
Query: 3 LLVAPLLLAWVAGATAAVP---VVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLF 59
+ + PLLL + A A+ P P PCP +C CQ + +V C
Sbjct: 1 MAILPLLLCLLPLAPASSPPQSATP--SPCPRRCRCQTQSL---------PLSVLCPGAG 49
Query: 60 LTAVPPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQL 119
L VPP+L L L N I V + +L + L L LS+N+ F L L
Sbjct: 50 LLFVPPSLDRRAAELRLADNFIASVRRRDLANMTGLLHLSLSRNTIRHVAAGAFADLRAL 109
Query: 120 LSLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLR-LHLNSNLLR 178
+LHL+ N+LT L + GL +L+ L L++NQL +A A + L L L+ N L
Sbjct: 110 RALHLDGNRLTSLGEGQLRGLVNLRHLILSNNQLAALAAGALDDCAETLEDLDLSYNNLE 169
Query: 179 AIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREI 228
+ L N+ L + N + ++ F L L L + L I
Sbjct: 170 QLPWEALGRLGNVNTLGLDHNLLASVPAGAFSRLHKLARLDMTSNRLTTI 219
>gi|4504379 leucine-rich repeat-containing G protein-coupled
receptor 5 [Homo sapiens]
Length = 907
Score = 124 bits (311), Expect = 3e-28
Identities = 114/390 (29%), Positives = 168/390 (43%), Gaps = 59/390 (15%)
Query: 3 LLVAPLLLAWVAGATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFLTA 62
LL P+LL G ++ V CP C C+ R VDC+DL L+
Sbjct: 9 LLSLPVLLQLATGGSSPRSGVLLR-GCPTHCHCE--------PDGRMLLRVDCSDLGLSE 59
Query: 63 VPPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSL 122
+P L T L L N+I ++ + L L L EL L+ N+ + F L L L
Sbjct: 60 LPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVL 119
Query: 123 HLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDS 182
L+ NQL + + L SLQ L L+ N + + P FSGL +L L L+ N L I
Sbjct: 120 MLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPV 179
Query: 183 RWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESL 242
+ FR L+ L+++ LA + I DYA L SL L
Sbjct: 180 Q------------------------AFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVL 215
Query: 243 SFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSID 302
++N++ + ++ + + L+ LDLN N L P + +LKELG ++ + SI
Sbjct: 216 HLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEF-PTAIRTLSNLKELGFHS-NNIRSIP 273
Query: 303 KFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNA---------------- 346
+ A V P L + +NP + F+ AF HLP++ TL LN +
Sbjct: 274 EKAFVGNPSLITIHFYDNP-IQFVGRSAFQHLPELRTLTLNGASQITEFPDLTGTANLES 332
Query: 347 -------LSALHQQTVESLPNLQEVGLHGN 369
+S+L Q LPNLQ + L N
Sbjct: 333 LTLTGAQISSLPQTVCNQLPNLQVLDLSYN 362
Score = 115 bits (287), Expect = 2e-25
Identities = 95/312 (30%), Positives = 153/312 (49%), Gaps = 11/312 (3%)
Query: 60 LTAVPPALPAGTQTLL---LQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHAL 116
++ VPP+ +G +L L N++ + L+ L + L+ N D F L
Sbjct: 150 ISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNL 209
Query: 117 PQLLSLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNL 176
L+ LHL N++ L F GL SL+ L LN+N L P A LSNL L +SN
Sbjct: 210 SSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEF-PTAIRTLSNLKELGFHSNN 268
Query: 177 LRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYA-LEG 235
+R+I + F P+L + N + + F+ L LR+L L G + +I+++ L G
Sbjct: 269 IRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGAS--QITEFPDLTG 326
Query: 236 LQSLESLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNM 295
+LESL+ Q++ +P+ Q+P L+ LDL+ N L+ + L +L N +
Sbjct: 327 TANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHNEI 386
Query: 296 EELVSIDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTV 355
E + +D F L L L++ N +++ IHP AF LP + L L++N LS+ +
Sbjct: 387 YE-IKVDTFQ--QLLSLRSLNLAWN-KIAIIHPNAFSTLPSLIKLDLSSNLLSSFPITGL 442
Query: 356 ESLPNLQEVGLH 367
L +L+ G H
Sbjct: 443 HGLTHLKLTGNH 454
Score = 76.6 bits (187), Expect = 7e-14
Identities = 61/194 (31%), Positives = 95/194 (48%), Gaps = 10/194 (5%)
Query: 186 EMLPN-------LEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQS 238
++LPN LE L + GN + I F L +L+ L+L LR + AL+ L+S
Sbjct: 80 QLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRS 139
Query: 239 LESLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEEL 298
L+SL N ++ VP + L+ L L+ N L + F ++ L+ + L + ++
Sbjct: 140 LQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLA-LNKI 198
Query: 299 VSIDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESL 358
I +A NL L L + NN R+ + + F L +ETL LN N L + +L
Sbjct: 199 HHIPDYAFGNLSSLVVLHLHNN-RIHSLGKKCFDGLHSLETLDLNYNNLDEF-PTAIRTL 256
Query: 359 PNLQEVGLHGNPIR 372
NL+E+G H N IR
Sbjct: 257 SNLKELGFHSNNIR 270
Score = 73.9 bits (180), Expect = 5e-13
Identities = 69/271 (25%), Positives = 116/271 (42%), Gaps = 32/271 (11%)
Query: 107 DARDCDFHALPQLLS-----LHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAF 161
D D LP LS L L N +++L + L L+EL L N L I AF
Sbjct: 51 DCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAF 110
Query: 162 SGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLA 221
+GL +L L L +N LR + + + L +L+ L + N + + F L +LR L L
Sbjct: 111 TGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLD 170
Query: 222 GMNLREISDYALEGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDF 281
L EI A L +L++++ N++ +P A + L L L+ N + +G F
Sbjct: 171 DNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCF 230
Query: 282 ANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLM 341
+ L+ L LN ++D+F P A L ++ L
Sbjct: 231 DGLHSLETLDLNYN----NLDEF-----------------------PTAIRTLSNLKELG 263
Query: 342 LNNNALSALHQQTVESLPNLQEVGLHGNPIR 372
++N + ++ ++ P+L + + NPI+
Sbjct: 264 FHSNNIRSIPEKAFVGNPSLITIHFYDNPIQ 294
>gi|149773484 leucine rich repeat and fibronectin type III domain
containing 1 [Homo sapiens]
Length = 771
Score = 124 bits (310), Expect = 4e-28
Identities = 108/398 (27%), Positives = 159/398 (39%), Gaps = 77/398 (19%)
Query: 118 QLLSLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLL 177
+++ L L +N + + FA + SL L L+ N + ++A AF+ L L LHL+SN L
Sbjct: 66 RVVELRLTDNFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRL 125
Query: 178 RAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEG-L 236
+ R L NLR L+L +R + A + L
Sbjct: 126 AEVRGD------------------------QLRGLGNLRHLILGNNQIRRVESAAFDAFL 161
Query: 237 QSLESLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNME 296
++E L N L +P A+ Q+ L L L+ N + + G F
Sbjct: 162 STVEDLDLSYNNLEALPWEAVGQMVNLNTLTLDHNLIDHIAEGTF--------------- 206
Query: 297 ELVSIDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVE 356
V L +L +LD+T+N H LP + L Q T
Sbjct: 207 ----------VQLHKLVRLDMTSN---------RLHKLPP--------DGLFLRSQGTGP 239
Query: 357 SLPNLQEVGLHGNPIRCDCVIRWANATGTRVRFIEPQSTLCAEPPDLQRLPVREVPFREM 416
P V GNP+ C+C + W TR E CA P L +P E
Sbjct: 240 KPPTPLTVSFGGNPLHCNCELLWLRRL-TR----EDDLETCATPEHLTDRYFWSIPEEEF 294
Query: 417 TDHCLPLISPRSFPPSLQVASGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRV 476
C P + R V G+++ L CRA+ +PEP ++WV P G L + R RV
Sbjct: 295 L--CEPPLITRQAGGRALVVEGQAVSLRCRAVGDPEPVVHWVAPDGRLLGNS---SRTRV 349
Query: 477 YPEGTLELRRVTAEEAGLYTCVAQNLVGADTKTVSVVV 514
+GTL++ T ++G +TC+A N G T V V V
Sbjct: 350 RGDGTLDVTITTLRDSGTFTCIASNAAGEATAPVEVCV 387
Score = 81.3 bits (199), Expect = 3e-15
Identities = 66/222 (29%), Positives = 96/222 (43%), Gaps = 18/222 (8%)
Query: 8 LLLAWVAGATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPAL 67
LLL W AGA+ P CP +C CQ + T+ C L VPPA+
Sbjct: 21 LLLLW-AGASRGQP-------CPGRCICQ---------NVAPTLTMLCAKTGLLFVPPAI 63
Query: 68 PAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEEN 127
L L N I V + + + +L L LS+N+ F L L +LHL+ N
Sbjct: 64 DRRVVELRLTDNFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSN 123
Query: 128 QLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSG-LSNLLRLHLNSNLLRAIDSRWFE 186
+L + GL +L+ L L +NQ+ R+ AF LS + L L+ N L A+
Sbjct: 124 RLAEVRGDQLRGLGNLRHLILGNNQIRRVESAAFDAFLSTVEDLDLSYNNLEALPWEAVG 183
Query: 187 MLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREI 228
+ NL L + N +D I + F L L L + L ++
Sbjct: 184 QMVNLNTLTLDHNLIDHIAEGTFVQLHKLVRLDMTSNRLHKL 225
>gi|51317373 netrin-G1 ligand [Homo sapiens]
Length = 640
Score = 123 bits (308), Expect = 7e-28
Identities = 114/438 (26%), Positives = 185/438 (42%), Gaps = 78/438 (17%)
Query: 190 NLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQL 249
N +L + N++ I +F+ L +L L L+ ++R I A GL +L +L +DN+L
Sbjct: 77 NTRLLNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRL 136
Query: 250 ARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDK------ 303
+P A + LK L L NP++ + F + L+ L L ++ L I +
Sbjct: 137 TTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGL 196
Query: 304 -------FALVNLPE---------LTKLDITNNPRLSFIHP------------------- 328
A+ NL E L +LD++ N LS I P
Sbjct: 197 SNLRYLNLAMCNLREIPNLTPLIKLDELDLSGN-HLSAIRPGSFQGLMHLQKLWMIQSQI 255
Query: 329 -----RAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRCDCVIRWANAT 383
AF +L + + L +N L+ L L +L+ + LH NP C+C I W +
Sbjct: 256 QVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHNPWNCNCDILWLS-- 313
Query: 384 GTRVRFIEPQSTLCA----EPPDLQRLPVREVPFREMTDHCLPLISPRSFPPSLQVASGE 439
++ + P +T C PP+L+ + E+ T + ++ P P L V G
Sbjct: 314 -WWIKDMAPSNTACCARCNTPPNLKGRYIGELDQNYFTCYAPVIVEP---PADLNVTEGM 369
Query: 440 SMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEGTLELRRVTAEEAGLYTCVA 499
+ L CRA + + W+TP G +T R V +GTL VT ++ G+YTC+
Sbjct: 370 AAELKCRA-STSLTSVSWITPNGTVMTHGAYKVRIAVLSDGTLNFTNVTVQDTGMYTCMV 428
Query: 500 QNLVGADTKTVSVVVGRA--------------LLQPGRDEGQGLELRVQETHPYHILLSW 545
N VG T + ++ V A ++P +DE + + V T ++ W
Sbjct: 429 SNSVGNTTASATLNVTAATTTPFSYFSTVTVETMEPSQDEARTTDNNVGPTP----VVDW 484
Query: 546 VTPPNTVSTNLTWSSASS 563
T V+T+LT S S
Sbjct: 485 ET--TNVTTSLTPQSTRS 500
Score = 92.4 bits (228), Expect = 1e-18
Identities = 82/294 (27%), Positives = 130/294 (44%), Gaps = 14/294 (4%)
Query: 2 RLLVAPLLLAWVAGATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFLT 61
R L PLL+ +A V + CP C+C + + V C L
Sbjct: 20 RALFDPLLVVLLALQLLVVAGLVRAQTCPSVCSCS-----------NQFSKVICVRKNLR 68
Query: 62 AVPPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLS 121
VP + T+ L L N I + + +L +L L LS+N F+ L L +
Sbjct: 69 EVPDGISTNTRLLNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNT 128
Query: 122 LHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNS-NLLRAI 180
L L +N+LT + + +F L+ L+EL+L +N + I AF+ + +L RL L L I
Sbjct: 129 LELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYI 188
Query: 181 DSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLE 240
FE L NL L + + I N PL L L L+G +L I + +GL L+
Sbjct: 189 SEGAFEGLSNLRYLNLAMCNLREI--PNLTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQ 246
Query: 241 SLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNN 294
L +Q+ + R A + + L ++L N L + F + HL+ + L++
Sbjct: 247 KLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHH 300
Score = 52.0 bits (123), Expect = 2e-06
Identities = 32/84 (38%), Positives = 45/84 (53%)
Query: 92 LANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELYLNHN 151
L L ELDLS N S R F L L L + ++Q+ +E ++F L SL E+ L HN
Sbjct: 218 LIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHN 277
Query: 152 QLYRIAPRAFSGLSNLLRLHLNSN 175
L + F+ L +L R+HL+ N
Sbjct: 278 NLTLLPHDLFTPLHHLERIHLHHN 301
>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
isoform 2 [Homo sapiens]
Length = 1119
Score = 122 bits (305), Expect = 2e-27
Identities = 138/491 (28%), Positives = 200/491 (40%), Gaps = 42/491 (8%)
Query: 53 VDCNDLFLTAVPPALPAGTQTLLLQ--SNSIVRVDQSELGYLANLTELDLSQNSFSDARD 110
V N+ L +P P LL N IV + L +L LDLS N+ S+ +
Sbjct: 103 VKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQT 162
Query: 111 CDFHALPQLLSLHLEENQLTRLEDHSFAGLAS-LQELYLNHNQLYRIAPRAFSGLSNLLR 169
F AL QL L+L N++T +E F LA+ L L LN N++ I P+ F L L
Sbjct: 163 A-FPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFK-LPQLQH 219
Query: 170 LHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREIS 229
L LN N ++ +D F+ L L+ L + N V ++D F L+N+ L L NL EI+
Sbjct: 220 LELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEIT 279
Query: 230 DYALEGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDF-----ANM 284
L GL L+ L N + R+ A E L LDL N L R+ F N
Sbjct: 280 KGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNT 339
Query: 285 LH-------------------LKELGLNNMEELVSIDKF--ALVNLPELTKLDITNNPRL 323
LH LK L L N E +I+ A L +L +L + N R+
Sbjct: 340 LHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGN-RI 398
Query: 324 SFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRCDCVIRWANAT 383
I +AF L +E L L++NA+ +L + LQ++ L+ + + CDC ++W
Sbjct: 399 RSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQW 458
Query: 384 GTRVRFIEPQSTLCAEPPDLQRLPVREVPFREMTDHCLPLISPRSFPPSLQVASGESMVL 443
F + CA P L+ + V P P + G ++
Sbjct: 459 VAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSNLSF 518
Query: 444 HCRALAEPEPEIYWVTPAGLRL-------TPAHAGRRYRVYPEGT--LELRRVTAEEAGL 494
C A + + + + L AH + E T L LR V G
Sbjct: 519 ICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGK 578
Query: 495 YTCVAQNLVGA 505
Y CV N G+
Sbjct: 579 YQCVISNHFGS 589
Score = 115 bits (288), Expect = 1e-25
Identities = 137/510 (26%), Positives = 200/510 (39%), Gaps = 75/510 (14%)
Query: 60 LTAVPPA---LPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHAL 116
++A+PP LP Q L L N I VD L L L + +N + D F L
Sbjct: 204 ISAIPPKMFKLPQ-LQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGL 262
Query: 117 PQLLSLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNL 176
+ L L+ N LT + GL LQEL+L+ N + RI+P A+ L L L N
Sbjct: 263 SNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNH 322
Query: 177 LRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLR---EISDYAL 233
L +D F L L L IG N+V I D FR L++L++L L + E + A
Sbjct: 323 LSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAF 382
Query: 234 EGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGL- 292
GL L L N++ + ++A + L+ LDL+ N + + F+ M L++L L
Sbjct: 383 SGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLN 442
Query: 293 -------------------NNMEELV------------------SIDKFALVNLPELTKL 315
NN + V S D F + P K
Sbjct: 443 TSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFP---KP 499
Query: 316 DITNNPR---------LSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGL 366
IT P LSFI A M +N L LH +E+ +L+ G
Sbjct: 500 QITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNEL--LHDAEMENYAHLRAQG- 556
Query: 367 HGNPIRCDCVIRWANATGTRVRFIEPQSTLCAEPPDL-QRLPVREVPFREMTDHCLPLIS 425
G + ++R V F C V+ ++T + LP +
Sbjct: 557 -GEVMEYTTILRLRE-----VEFASEGKYQCVISNHFGSSYSVKA----KLTVNMLPSFT 606
Query: 426 PRSFPPSLQVASGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEGTLE-L 484
P L + +G L C A+ P P+I W G PA RR V PE + +
Sbjct: 607 KT--PMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDF-PAARERRMHVMPEDDVFFI 663
Query: 485 RRVTAEEAGLYTCVAQNLVGADTKTVSVVV 514
V E+ G+Y+C AQN G+ + ++ V
Sbjct: 664 VDVKIEDIGVYSCTAQNSAGSISANATLTV 693
Score = 33.5 bits (75), Expect = 0.70
Identities = 24/84 (28%), Positives = 37/84 (44%), Gaps = 11/84 (13%)
Query: 435 VASGESMVLHCRALAEPEPEIYWV-TPAGLRLTPAH---AGRRYRVYPEGTLELRRVTAE 490
V GE+ VL C A P P++ W + L +T H AG + + + +
Sbjct: 708 VTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDV-------S 760
Query: 491 EAGLYTCVAQNLVGADTKTVSVVV 514
+AG YTC N +G + V + V
Sbjct: 761 DAGKYTCEMSNTLGTERGNVRLSV 784
>gi|209862903 leucine-rich repeats and immunoglobulin-like domains 3
isoform 1 [Homo sapiens]
Length = 1059
Score = 122 bits (305), Expect = 2e-27
Identities = 138/491 (28%), Positives = 200/491 (40%), Gaps = 42/491 (8%)
Query: 53 VDCNDLFLTAVPPALPAGTQTLLLQ--SNSIVRVDQSELGYLANLTELDLSQNSFSDARD 110
V N+ L +P P LL N IV + L +L LDLS N+ S+ +
Sbjct: 43 VKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQT 102
Query: 111 CDFHALPQLLSLHLEENQLTRLEDHSFAGLAS-LQELYLNHNQLYRIAPRAFSGLSNLLR 169
F AL QL L+L N++T +E F LA+ L L LN N++ I P+ F L L
Sbjct: 103 A-FPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFK-LPQLQH 159
Query: 170 LHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREIS 229
L LN N ++ +D F+ L L+ L + N V ++D F L+N+ L L NL EI+
Sbjct: 160 LELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEIT 219
Query: 230 DYALEGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDF-----ANM 284
L GL L+ L N + R+ A E L LDL N L R+ F N
Sbjct: 220 KGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNT 279
Query: 285 LH-------------------LKELGLNNMEELVSIDKF--ALVNLPELTKLDITNNPRL 323
LH LK L L N E +I+ A L +L +L + N R+
Sbjct: 280 LHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGN-RI 338
Query: 324 SFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRCDCVIRWANAT 383
I +AF L +E L L++NA+ +L + LQ++ L+ + + CDC ++W
Sbjct: 339 RSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQW 398
Query: 384 GTRVRFIEPQSTLCAEPPDLQRLPVREVPFREMTDHCLPLISPRSFPPSLQVASGESMVL 443
F + CA P L+ + V P P + G ++
Sbjct: 399 VAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSNLSF 458
Query: 444 HCRALAEPEPEIYWVTPAGLRL-------TPAHAGRRYRVYPEGT--LELRRVTAEEAGL 494
C A + + + + L AH + E T L LR V G
Sbjct: 459 ICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGK 518
Query: 495 YTCVAQNLVGA 505
Y CV N G+
Sbjct: 519 YQCVISNHFGS 529
Score = 115 bits (288), Expect = 1e-25
Identities = 137/510 (26%), Positives = 200/510 (39%), Gaps = 75/510 (14%)
Query: 60 LTAVPPA---LPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHAL 116
++A+PP LP Q L L N I VD L L L + +N + D F L
Sbjct: 144 ISAIPPKMFKLPQ-LQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGL 202
Query: 117 PQLLSLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNL 176
+ L L+ N LT + GL LQEL+L+ N + RI+P A+ L L L N
Sbjct: 203 SNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNH 262
Query: 177 LRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLR---EISDYAL 233
L +D F L L L IG N+V I D FR L++L++L L + E + A
Sbjct: 263 LSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAF 322
Query: 234 EGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGL- 292
GL L L N++ + ++A + L+ LDL+ N + + F+ M L++L L
Sbjct: 323 SGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLN 382
Query: 293 -------------------NNMEELV------------------SIDKFALVNLPELTKL 315
NN + V S D F + P K
Sbjct: 383 TSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFP---KP 439
Query: 316 DITNNPR---------LSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGL 366
IT P LSFI A M +N L LH +E+ +L+ G
Sbjct: 440 QITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNEL--LHDAEMENYAHLRAQG- 496
Query: 367 HGNPIRCDCVIRWANATGTRVRFIEPQSTLCAEPPDL-QRLPVREVPFREMTDHCLPLIS 425
G + ++R V F C V+ ++T + LP +
Sbjct: 497 -GEVMEYTTILRLRE-----VEFASEGKYQCVISNHFGSSYSVKA----KLTVNMLPSFT 546
Query: 426 PRSFPPSLQVASGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEGTLE-L 484
P L + +G L C A+ P P+I W G PA RR V PE + +
Sbjct: 547 KT--PMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDF-PAARERRMHVMPEDDVFFI 603
Query: 485 RRVTAEEAGLYTCVAQNLVGADTKTVSVVV 514
V E+ G+Y+C AQN G+ + ++ V
Sbjct: 604 VDVKIEDIGVYSCTAQNSAGSISANATLTV 633
Score = 69.3 bits (168), Expect = 1e-11
Identities = 80/322 (24%), Positives = 129/322 (40%), Gaps = 76/322 (23%)
Query: 124 LEENQLTRLEDHSFAGLASLQELYLNHNQLYRI--------------------------- 156
L N+L+ ++ S + L SL+E+ LN+N+L I
Sbjct: 21 LSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEH 80
Query: 157 -------------------APRAFSGLSNLLRLHLNSNLLRAIDSRWFE----------- 186
AF L L L+LNSN + +++ +F+
Sbjct: 81 LKEFQSLETLDLSSNNISELQTAFPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLLVLKL 139
Query: 187 -------------MLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYAL 233
LP L+ L + NK+ + + F+ L L+SL + + ++ D A
Sbjct: 140 NRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAF 199
Query: 234 EGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLN 293
GL ++E L N L + + L + L+ L L++N + R+ P + L EL L
Sbjct: 200 WGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDL- 258
Query: 294 NMEELVSIDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQ 353
L +D + + L L L I NN R+S+I AF L ++TL L NN +S +
Sbjct: 259 TFNHLSRLDDSSFLGLSLLNTLHIGNN-RVSYIADCAFRGLSSLKTLDLKNNEISWTIED 317
Query: 354 ---TVESLPNLQEVGLHGNPIR 372
L L+ + L GN IR
Sbjct: 318 MNGAFSGLDKLRRLILQGNRIR 339
Score = 39.7 bits (91), Expect = 0.010
Identities = 49/194 (25%), Positives = 82/194 (42%), Gaps = 27/194 (13%)
Query: 201 VDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARVP------- 253
VD +L + L ++ L+ L I ++ LQSL + +N+L +P
Sbjct: 2 VDVLLLFSLCLLFHISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSA 61
Query: 254 ---------RRALEQVP-------GLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEE 297
R +E +P L+ LDL+ N + + A L LK L LN+
Sbjct: 62 NITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQTAFPA--LQLKYLYLNS-NR 118
Query: 298 LVSIDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVES 357
+ S++ NL + N R+S I P+ F LPQ++ L LN N + + T +
Sbjct: 119 VTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMF-KLPQLQHLELNRNKIKNVDGLTFQG 177
Query: 358 LPNLQEVGLHGNPI 371
L L+ + + N +
Sbjct: 178 LGALKSLKMQRNGV 191
Score = 36.6 bits (83), Expect = 0.083
Identities = 38/141 (26%), Positives = 65/141 (46%), Gaps = 5/141 (3%)
Query: 267 DLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNPRLSFI 326
DL+ N L + +++ L+E+ LNN EL +I V+ +T L + N R+ I
Sbjct: 20 DLSHNRLSFIKASSMSHLQSLREVKLNN-NELETIPNLGPVS-ANITLLSLAGN-RIVEI 76
Query: 327 HPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRCDCVIRWANATGTR 386
P +ETL L++N +S L QT L+ + L+ N + + N T
Sbjct: 77 LPEHLKEFQSLETLDLSSNNISEL--QTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTL 134
Query: 387 VRFIEPQSTLCAEPPDLQRLP 407
+ ++ + A PP + +LP
Sbjct: 135 LVLKLNRNRISAIPPKMFKLP 155
Score = 33.5 bits (75), Expect = 0.70
Identities = 24/84 (28%), Positives = 37/84 (44%), Gaps = 11/84 (13%)
Query: 435 VASGESMVLHCRALAEPEPEIYWV-TPAGLRLTPAH---AGRRYRVYPEGTLELRRVTAE 490
V GE+ VL C A P P++ W + L +T H AG + + + +
Sbjct: 648 VTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDV-------S 700
Query: 491 EAGLYTCVAQNLVGADTKTVSVVV 514
+AG YTC N +G + V + V
Sbjct: 701 DAGKYTCEMSNTLGTERGNVRLSV 724
>gi|7662320 leucine-rich repeats and immunoglobulin-like domains 2
[Homo sapiens]
Length = 1065
Score = 120 bits (301), Expect = 4e-27
Identities = 115/415 (27%), Positives = 184/415 (44%), Gaps = 36/415 (8%)
Query: 68 PAGTQTLL-LQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEE 126
P TLL L N I ++ L + L LDLS N S+ + F + QL L+L
Sbjct: 118 PTSNITLLSLVHNIIPEINAQALQFYPALESLDLSSNIISEIKTSSFPRM-QLKYLNLSN 176
Query: 127 NQLTRLEDHSFAGL-ASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWF 185
N++T LE F L +SL + LN N++ I P+ F L +L L L N ++ ++ F
Sbjct: 177 NRITTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIFK-LPHLQFLELKRNRIKIVEGLTF 235
Query: 186 EMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFY 245
+ L +L L + N + + D F L N+ L L NL ++ L GL+ L+ L
Sbjct: 236 QGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVS 295
Query: 246 DNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNN----------- 294
N + R+ A E L LDL+ N L R+ F + L+ L L +
Sbjct: 296 QNAIERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVF 355
Query: 295 --MEELVSID-------------KFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMET 339
+ L ++D A L LTKL + N ++ I +AF L +E
Sbjct: 356 RFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGN-QIKSITKKAFIGLESLEH 414
Query: 340 LMLNNNALSALHQQTVESLPNLQEVGLHGNPIRCDCVIRWANATGTRVRFIEPQSTLCAE 399
L LNNNA+ ++ Q+ S +L+E+ L+ + + CDC ++W F + CA
Sbjct: 415 LDLNNNAIMSI-QENAFSQTHLKELILNTSSLLCDCHLKWLLQWLVDNNFQHSVNVSCAH 473
Query: 400 PPDLQRLPVREVPFREMTDHCLPLISP--RSFPPSLQVASGESMVLHCRALAEPE 452
P L + V ++ C + P R+ P ++ G ++ L C A++ +
Sbjct: 474 PEWLAGQSILNVDLKDFV--CDDFLKPQIRTHPETIIALRGMNVTLTCTAVSSSD 526
Score = 55.5 bits (132), Expect = 2e-07
Identities = 48/177 (27%), Positives = 82/177 (46%), Gaps = 11/177 (6%)
Query: 203 AILDMNFRPLANL------RSLVLAGMNLREISD--YALEGLQSLESLSFYDNQLARVPR 254
AILD + L+N ++L MN E+++ Y E ++ LS N + +
Sbjct: 78 AILDFSHNRLSNWNISLESQTLQEVKMNYNELTEIPYFGEPTSNITLLSLVHNIIPEINA 137
Query: 255 RALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTK 314
+AL+ P L+ LDL+ N + + F M LK L L+N + +++ NL
Sbjct: 138 QALQFYPALESLDLSSNIISEIKTSSFPRM-QLKYLNLSN-NRITTLEAGCFDNLSSSLL 195
Query: 315 LDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPI 371
+ N R+S I P+ F LP ++ L L N + + T + L +L+ + + N I
Sbjct: 196 VVKLNRNRMSMIPPKIF-KLPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGI 251
Score = 48.1 bits (113), Expect = 3e-05
Identities = 29/86 (33%), Positives = 40/86 (46%), Gaps = 2/86 (2%)
Query: 430 PPSLQVASGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEGTLE-LRRVT 488
P L + +G L C A P P+I W G PA RR V PE + + V
Sbjct: 608 PMDLTIRTGAMARLECAAEGHPAPQISWQKDGGTDF-PAARERRMHVMPEDDVFFIANVK 666
Query: 489 AEEAGLYTCVAQNLVGADTKTVSVVV 514
E+ G+Y+C+AQN G + S+ V
Sbjct: 667 IEDMGIYSCMAQNTAGGLSANASLTV 692
Score = 36.6 bits (83), Expect = 0.083
Identities = 22/72 (30%), Positives = 30/72 (41%), Gaps = 3/72 (4%)
Query: 435 VASGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEGTLELRRVTAEEAGL 494
V GE+ VL C A P P + W G L R + L + E+AG
Sbjct: 707 VTRGETAVLQCIAGGSPAPRLNWTKDDGPLLV---TERHFFAAANQLLIIVDAGLEDAGK 763
Query: 495 YTCVAQNLVGAD 506
YTC+ N +G +
Sbjct: 764 YTCIMSNTLGTE 775
>gi|157694513 leucine-rich repeat-containing G protein-coupled
receptor 4 [Homo sapiens]
Length = 951
Score = 119 bits (297), Expect = 1e-26
Identities = 102/365 (27%), Positives = 161/365 (44%), Gaps = 51/365 (13%)
Query: 53 VDCNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCD 112
VDC+ LTAVP L A TQ L + N+I ++ + L EL L+ N S
Sbjct: 41 VDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKA 100
Query: 113 FHALPQLLSLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHL 172
L +L L L+ NQL + + GL++LQ L L+ N + + +F GL L L L
Sbjct: 101 LSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWL 160
Query: 173 NSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYA 232
+ N L + LP L+ L + NK+ +I D F L++L L L +R +S +
Sbjct: 161 DDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHC 220
Query: 233 LEGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGL 292
+GL +LE+L N L P +A++ +P LK L + N + + G F
Sbjct: 221 FDGLDNLETLDLNYNNLGEFP-QAIKALPSLKELGFHSNSISVIPDGAFDGN-------- 271
Query: 293 NNMEELVSIDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQ 352
P L + + +NP LSF+ AFH+L + +L++ ++
Sbjct: 272 -----------------PLLRTIHLYDNP-LSFVGNSAFHNLSDLHSLVIRGASM----- 308
Query: 353 QTVESLPNLQEVGLHGNPIRCDCVIRWANATGTRVRFIEPQSTLCAEPPDLQRLP----- 407
V+ PNL +H + TGT++ I + LC E L+ L
Sbjct: 309 --VQQFPNLTGT-VH---------LESLTLTGTKISSI--PNNLCQEQKMLRTLDLSYNN 354
Query: 408 VREVP 412
+R++P
Sbjct: 355 IRDLP 359
Score = 49.3 bits (116), Expect = 1e-05
Identities = 38/124 (30%), Positives = 63/124 (50%), Gaps = 6/124 (4%)
Query: 95 LTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELYLNHNQLY 154
L LDLS N+ D F+ L + L+ NQ+ ++++ +F GL SL+ L L+ N ++
Sbjct: 345 LRTLDLSYNNIRDLPS--FNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIH 402
Query: 155 RIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLAN 214
I RAF+ L + L ++ N L + + L L+ ++G K+ L + N
Sbjct: 403 EIHSRAFATLGPITNLDVSFNELTSFPTEGLNGLNQLK--LVGNFKLKEALAA--KDFVN 458
Query: 215 LRSL 218
LRSL
Sbjct: 459 LRSL 462
Score = 46.6 bits (109), Expect = 8e-05
Identities = 41/136 (30%), Positives = 67/136 (49%), Gaps = 16/136 (11%)
Query: 119 LLSLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLR 178
L +L L N + L SF G +L+E+ L NQ+Y+I F GL +L L L+ NL+
Sbjct: 345 LRTLDLSYNNIRDLP--SFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIH 402
Query: 179 AIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMN-LREISDYALEGLQ 237
I SR F L + LD++F L + + L G+N L+ + ++ L+ +
Sbjct: 403 EIHSRAFATLGPI-----------TNLDVSFNELTSFPTEGLNGLNQLKLVGNFKLK--E 449
Query: 238 SLESLSFYDNQLARVP 253
+L + F + + VP
Sbjct: 450 ALAAKDFVNLRSLSVP 465
Score = 33.1 bits (74), Expect = 0.92
Identities = 26/96 (27%), Positives = 42/96 (43%), Gaps = 1/96 (1%)
Query: 72 QTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTR 131
+ + LQ N I ++ + L +L LDLS+N + F L + +L + N+LT
Sbjct: 368 EEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTS 427
Query: 132 LEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNL 167
GL L +L N +A + F L +L
Sbjct: 428 FPTEGLNGLNQL-KLVGNFKLKEALAAKDFVNLRSL 462
>gi|194440719 chondroadherin-like [Homo sapiens]
Length = 762
Score = 118 bits (296), Expect = 2e-26
Identities = 113/380 (29%), Positives = 152/380 (40%), Gaps = 73/380 (19%)
Query: 28 PCPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQS 87
PCP C C P S + C L AVP P+ TQ L
Sbjct: 395 PCPRACVC------VPESRHSS-----CEGCGLQAVPRGFPSDTQLL------------- 430
Query: 88 ELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELY 147
DL +N F F L L+SLHL+ + LE + AGL L LY
Sbjct: 431 -----------DLRRNHFPSVPRAAFPGLGHLVSLHLQHCGIAELEAGALAGLGRLIYLY 479
Query: 148 LNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDM 207
L+ NQL ++ A G L L+L N + LP+L L + N VD +
Sbjct: 480 LSDNQLAGLSAAALEGAPRLGYLYLERNRFLQVPGAALRALPSLFSLHLQDNAVDRLAPG 539
Query: 208 NFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARVPRRALEQVPGLKFLD 267
+ LR + L+G + E+S AL + LE L NQL VP ALE +P L L
Sbjct: 540 DLGRTRALRWVYLSGNRITEVSLGALGPARELEKLHLDRNQLREVPTGALEGLPALLELQ 599
Query: 268 LNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNPRLSFIH 327
L+ NPL+ + G F + +G +++ L N+ L I
Sbjct: 600 LSGNPLRALRDGAF------QPVG-RSLQHL------------------FLNSSGLEQIC 634
Query: 328 PRAFHHL-PQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRCDCVI----RWANA 382
P AF L P +++L L N L AL + SL L+ + L NP CDC + RW
Sbjct: 635 PGAFSGLGPGLQSLHLQKNQLRAL--PALPSLSQLELIDLSSNPFHCDCQLLPLHRWLTG 692
Query: 383 TGTRVRFIEPQSTLCAEPPD 402
RV CA PP+
Sbjct: 693 LNLRV------GATCATPPN 706
Score = 112 bits (279), Expect = 2e-24
Identities = 102/350 (29%), Positives = 140/350 (40%), Gaps = 63/350 (18%)
Query: 29 CPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQSE 88
CP C C +S R V C LT VP A+P TQ L LQ N + + +
Sbjct: 33 CPQACICD--------NSRRH---VACRYQNLTEVPDAIPELTQRLDLQGNLLKVIPAAA 81
Query: 89 LGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELYL 148
+ +LT LDL + F L +LL L+L N L L + GL SL+ L L
Sbjct: 82 FQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQEALDGLGSLRRLEL 141
Query: 149 NHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMN 208
N L + P F L L L+L N L + + M
Sbjct: 142 EGNALEELRPGTFGALGALATLNLAHNALVYLPA------------------------MA 177
Query: 209 FRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDL 268
F+ L +R L L+ L ++ AL GL +L LS + N+L +P L Q GL L+L
Sbjct: 178 FQGLLRVRWLRLSHNALSVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLEL 237
Query: 269 NKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNPRLSFIHP 328
NPL G D + L+EL + + L + P
Sbjct: 238 GHNPLTYAGEEDGLALPGLREL--------------------------LLDGGALQALGP 271
Query: 329 RAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRCDCVIR 378
RAF H P++ TL L N L L ++ L+ + L GNP+ C C R
Sbjct: 272 RAFAHCPRLHTLDLRGNQLDTL--PPLQGPGQLRRLRLQGNPLWCGCQAR 319
>gi|62912470 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 1 [Homo sapiens]
Length = 967
Score = 118 bits (295), Expect = 2e-26
Identities = 99/321 (30%), Positives = 148/321 (46%), Gaps = 38/321 (11%)
Query: 24 PWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQTLLLQSNSIVR 83
P CP C CQ + DC++L L+AVP
Sbjct: 30 PGPTACPAPCHCQ---------EDGIMLSADCSELGLSAVP------------------- 61
Query: 84 VDQSELGYLANLTE-LDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLAS 142
G L LT LDLS N+ ++ + FH L L L L N L+ + +F+GL S
Sbjct: 62 ------GDLDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYS 115
Query: 143 LQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVD 202
L+ L L +NQL I A L +L L L++NL+ + R FE L +L L + N +
Sbjct: 116 LKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALT 175
Query: 203 AILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARVPRRALEQVPG 262
I L L+++ LA + I DYA + L SL L ++N++ + + E +
Sbjct: 176 EIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHN 235
Query: 263 LKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNPR 322
L+ LDLN N LQ P + L+ELG +N + +I + A + P L + +NP
Sbjct: 236 LETLDLNYNKLQEF-PVAIRTLGRLQELGFHN-NNIKAIPEKAFMGNPLLQTIHFYDNP- 292
Query: 323 LSFIHPRAFHHLPQMETLMLN 343
+ F+ AF +LP++ TL LN
Sbjct: 293 IQFVGRSAFQYLPKLHTLSLN 313
Score = 96.7 bits (239), Expect = 7e-20
Identities = 88/309 (28%), Positives = 136/309 (44%), Gaps = 46/309 (14%)
Query: 64 PPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLH 123
P A PA + ++ D SELG A +LD P L
Sbjct: 32 PTACPAPCHCQ--EDGIMLSADCSELGLSAVPGDLD-----------------PLTAYLD 72
Query: 124 LEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSR 183
L N LT L+ F L L+EL L+ N L I +AFSGL +L L L +N L I +
Sbjct: 73 LSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAE 132
Query: 184 WFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLS 243
LP+L+ L + N + + + +F L++LR L L L EI AL L +L++++
Sbjct: 133 ALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMT 192
Query: 244 FYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDK 303
N+++ +P A + + L L L+ N +Q +G F GL+N+E L
Sbjct: 193 LALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFE--------GLHNLETL----- 239
Query: 304 FALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQE 363
D+ N F P A L +++ L +NN + A+ ++ P LQ
Sbjct: 240 ------------DLNYNKLQEF--PVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQT 285
Query: 364 VGLHGNPIR 372
+ + NPI+
Sbjct: 286 IHFYDNPIQ 294
Score = 68.2 bits (165), Expect = 3e-11
Identities = 71/307 (23%), Positives = 115/307 (37%), Gaps = 68/307 (22%)
Query: 74 LLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLE 133
L L N++ + L L L + L+ N S D F L L+ LHL N++ L
Sbjct: 167 LWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLG 226
Query: 134 DHSFAGLASLQELYLNHNQLYR-----------------------IAPRAFSGLSNLLRL 170
HSF GL +L+ L LN+N+L I +AF G L +
Sbjct: 227 THSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTI 286
Query: 171 HLNSNLLRAIDSRWFEMLPNLEILMIGGNK-VDAILDMNFRPLANLRSLVLAGMNLR--- 226
H N ++ + F+ LP L L + G + D+ + +L AG+ L
Sbjct: 287 HFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSG 346
Query: 227 -----------EISDYALEGL------QSLESLSFYDNQLARVPRRALEQVPGLKFLDLN 269
E+S +E L Q LE + N++ + Q+ L+ LDL+
Sbjct: 347 MCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLS 406
Query: 270 KNPLQRVGPGDFANM------------------------LHLKELGLNNMEELVSIDKFA 305
N ++ + P F+ + +HLK G + + S D F
Sbjct: 407 WNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFP 466
Query: 306 LVNLPEL 312
+ + E+
Sbjct: 467 KLRILEV 473
Score = 48.1 bits (113), Expect = 3e-05
Identities = 44/138 (31%), Positives = 66/138 (47%), Gaps = 14/138 (10%)
Query: 116 LPQLLSLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSN 175
LP+L L L NQ+ L S L+E+ L HN+++ I FS LS+L L L+ N
Sbjct: 351 LPRLRVLELSHNQIEELP--SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWN 408
Query: 176 LLRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEG 235
+R+I F L +L L + N++ + PLA L L M+L+ + AL
Sbjct: 409 AIRSIHPEAFSTLHSLVKLDLTDNQLTTL------PLAGLGGL----MHLKLKGNLALS- 457
Query: 236 LQSLESLSFYDNQLARVP 253
Q+ SF ++ VP
Sbjct: 458 -QAFSKDSFPKLRILEVP 474
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.418
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,995,790
Number of Sequences: 37866
Number of extensions: 1379117
Number of successful extensions: 8156
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 294
Number of HSP's successfully gapped in prelim test: 266
Number of HSP's that attempted gapping in prelim test: 3619
Number of HSP's gapped (non-prelim): 2516
length of query: 713
length of database: 18,247,518
effective HSP length: 109
effective length of query: 604
effective length of database: 14,120,124
effective search space: 8528554896
effective search space used: 8528554896
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.