Search of human proteins with 41581463

Search of human proteins with 41581463

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|41581463 formin binding protein 1-like isoform 2 [Homo
sapiens]
         (547 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|41581463 formin binding protein 1-like isoform 2 [Homo sapiens]   1128   0.0  
gi|68348709 formin binding protein 1-like isoform 1 [Homo sapiens]   1127   0.0  
gi|38524622 formin binding protein 1 [Homo sapiens]                   610   e-174
gi|11342676 thyroid hormone receptor interactor 10 [Homo sapiens]     601   e-172
gi|182765466 FCH and double SH3 domains 2 [Homo sapiens]               81   3e-15
gi|112363100 SLIT-ROBO Rho GTPase activating protein 2 isoform a...    58   2e-08
gi|112363096 SLIT-ROBO Rho GTPase activating protein 2 isoform b...    58   2e-08
gi|20149528 proline-serine-threonine phosphatase interacting pro...    57   3e-08
gi|28875786 FCH and double SH3 domains 1 [Homo sapiens]                57   4e-08
gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]      54   3e-07
gi|44917604 SLIT-ROBO Rho GTPase activating protein 1 [Homo sapi...    51   2e-06
gi|189491776 nephrocystin 1 isoform 3 [Homo sapiens]                   51   3e-06
gi|189491774 nephrocystin 1 isoform 2 [Homo sapiens]                   51   3e-06
gi|46397398 nephrocystin 1 isoform 1 [Homo sapiens]                    51   3e-06
gi|24308229 protein kinase C and casein kinase substrate in neur...    51   3e-06
gi|75677374 SLIT-ROBO Rho GTPase activating protein 3 isoform b ...    50   5e-06
gi|24307967 SLIT-ROBO Rho GTPase activating protein 3 isoform a ...    50   5e-06
gi|148747351 protein kinase C and casein kinase substrate in neu...    50   5e-06
gi|194294523 intersectin 2 isoform 3 [Homo sapiens]                    49   1e-05
gi|11321634 CD2-associated protein [Homo sapiens]                      47   4e-05
gi|189491778 nephrocystin 1 isoform 4 [Homo sapiens]                   46   1e-04
gi|165905601 proline-serine-threonine phosphatase interacting pr...    45   1e-04
gi|114155142 nuclear pore complex-associated protein TPR [Homo s...    45   1e-04
gi|156071465 Rho GTPase activating protein 4 [Homo sapiens]            45   2e-04
gi|7706706 sorting nexin 9 [Homo sapiens]                              45   2e-04
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap...    45   2e-04
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi...    45   2e-04
gi|55956916 myosin IE [Homo sapiens]                                   45   2e-04
gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]    44   3e-04
gi|5453754 NCK adaptor protein 1 [Homo sapiens]                        44   3e-04

>gi|41581463 formin binding protein 1-like isoform 2 [Homo sapiens]
          Length = 547

 Score = 1128 bits (2918), Expect = 0.0
 Identities = 547/547 (100%), Positives = 547/547 (100%)

Query: 1   MSWGTELWDQFDSLDKHTQWGIDFLERYAKFVKERIEIEQNYAKQLRNLVKKYCPKRSSK 60
           MSWGTELWDQFDSLDKHTQWGIDFLERYAKFVKERIEIEQNYAKQLRNLVKKYCPKRSSK
Sbjct: 1   MSWGTELWDQFDSLDKHTQWGIDFLERYAKFVKERIEIEQNYAKQLRNLVKKYCPKRSSK 60

Query: 61  DEEPRFTSCVAFFNILNELNDYAGQREVVAEEMAHRVYGELMRYAHDLKTERKMHLQEGR 120
           DEEPRFTSCVAFFNILNELNDYAGQREVVAEEMAHRVYGELMRYAHDLKTERKMHLQEGR
Sbjct: 61  DEEPRFTSCVAFFNILNELNDYAGQREVVAEEMAHRVYGELMRYAHDLKTERKMHLQEGR 120

Query: 121 KAQQYLDMCWKQMDNSKKKFERECREAEKAQQSYERLDNDTNATKADVEKAKQQLNLRTH 180
           KAQQYLDMCWKQMDNSKKKFERECREAEKAQQSYERLDNDTNATKADVEKAKQQLNLRTH
Sbjct: 121 KAQQYLDMCWKQMDNSKKKFERECREAEKAQQSYERLDNDTNATKADVEKAKQQLNLRTH 180

Query: 181 MADENKNEYAAQLQNFNGEQHKHFYVVIPQIYKQLQEMDERRTIKLSECYRGFADSERKV 240
           MADENKNEYAAQLQNFNGEQHKHFYVVIPQIYKQLQEMDERRTIKLSECYRGFADSERKV
Sbjct: 181 MADENKNEYAAQLQNFNGEQHKHFYVVIPQIYKQLQEMDERRTIKLSECYRGFADSERKV 240

Query: 241 IPIISKCLEGMILAAKSVDERRDSQMVVDSFKSGFEPPGDFPFEDYSQHIYRTISDGTIS 300
           IPIISKCLEGMILAAKSVDERRDSQMVVDSFKSGFEPPGDFPFEDYSQHIYRTISDGTIS
Sbjct: 241 IPIISKCLEGMILAAKSVDERRDSQMVVDSFKSGFEPPGDFPFEDYSQHIYRTISDGTIS 300

Query: 301 ASKQESGKMDAKTTVGKAKGKLWLFGKKPKGPALEDFSHLPPEQRRKKLQQRIDELNREL 360
           ASKQESGKMDAKTTVGKAKGKLWLFGKKPKGPALEDFSHLPPEQRRKKLQQRIDELNREL
Sbjct: 301 ASKQESGKMDAKTTVGKAKGKLWLFGKKPKGPALEDFSHLPPEQRRKKLQQRIDELNREL 360

Query: 361 QKESDQKDALNKMKDVYEKNPQMGDPGSLQPKLAETMNNIDRLRMEIHKNEAWLSEVEGK 420
           QKESDQKDALNKMKDVYEKNPQMGDPGSLQPKLAETMNNIDRLRMEIHKNEAWLSEVEGK
Sbjct: 361 QKESDQKDALNKMKDVYEKNPQMGDPGSLQPKLAETMNNIDRLRMEIHKNEAWLSEVEGK 420

Query: 421 TGGRGDRRHSSDINHLVTQGRESPEGSYTDDANQEVRGPPQQHGHHNEFDDEFEDDDPLP 480
           TGGRGDRRHSSDINHLVTQGRESPEGSYTDDANQEVRGPPQQHGHHNEFDDEFEDDDPLP
Sbjct: 421 TGGRGDRRHSSDINHLVTQGRESPEGSYTDDANQEVRGPPQQHGHHNEFDDEFEDDDPLP 480

Query: 481 AIGHCKAIYPFDGHNEGTLAMKEGEVLYIIEEDKGDGWTRARRQNGEEGYVPTSYIDVTL 540
           AIGHCKAIYPFDGHNEGTLAMKEGEVLYIIEEDKGDGWTRARRQNGEEGYVPTSYIDVTL
Sbjct: 481 AIGHCKAIYPFDGHNEGTLAMKEGEVLYIIEEDKGDGWTRARRQNGEEGYVPTSYIDVTL 540

Query: 541 EKNSKGS 547
           EKNSKGS
Sbjct: 541 EKNSKGS 547


>gi|68348709 formin binding protein 1-like isoform 1 [Homo sapiens]
          Length = 551

 Score = 1127 bits (2915), Expect = 0.0
 Identities = 546/547 (99%), Positives = 547/547 (100%)

Query: 1   MSWGTELWDQFDSLDKHTQWGIDFLERYAKFVKERIEIEQNYAKQLRNLVKKYCPKRSSK 60
           MSWGTELWDQFDSLDKHTQWGIDFLERYAKFVKERIEIEQNYAKQLRNLVKKYCPKRSSK
Sbjct: 1   MSWGTELWDQFDSLDKHTQWGIDFLERYAKFVKERIEIEQNYAKQLRNLVKKYCPKRSSK 60

Query: 61  DEEPRFTSCVAFFNILNELNDYAGQREVVAEEMAHRVYGELMRYAHDLKTERKMHLQEGR 120
           DEEPRFTSCVAFFNILNELNDYAGQREVVAEEMAHRVYGELMRYAHDLKTERKMHLQEGR
Sbjct: 61  DEEPRFTSCVAFFNILNELNDYAGQREVVAEEMAHRVYGELMRYAHDLKTERKMHLQEGR 120

Query: 121 KAQQYLDMCWKQMDNSKKKFERECREAEKAQQSYERLDNDTNATKADVEKAKQQLNLRTH 180
           KAQQYLDMCWKQMDNSKKKFERECREAEKAQQSYERLDNDTNATKADVEKAKQQLNLRTH
Sbjct: 121 KAQQYLDMCWKQMDNSKKKFERECREAEKAQQSYERLDNDTNATKADVEKAKQQLNLRTH 180

Query: 181 MADENKNEYAAQLQNFNGEQHKHFYVVIPQIYKQLQEMDERRTIKLSECYRGFADSERKV 240
           MADENKNEYAAQLQNFNGEQHKHFYVVIPQIYKQLQEMDERRTIKLSECYRGFADSERKV
Sbjct: 181 MADENKNEYAAQLQNFNGEQHKHFYVVIPQIYKQLQEMDERRTIKLSECYRGFADSERKV 240

Query: 241 IPIISKCLEGMILAAKSVDERRDSQMVVDSFKSGFEPPGDFPFEDYSQHIYRTISDGTIS 300
           IPIISKCLEGMILAAKSVDERRDSQMVVDSFKSGFEPPGDFPFEDYSQHIYRTISDGTIS
Sbjct: 241 IPIISKCLEGMILAAKSVDERRDSQMVVDSFKSGFEPPGDFPFEDYSQHIYRTISDGTIS 300

Query: 301 ASKQESGKMDAKTTVGKAKGKLWLFGKKPKGPALEDFSHLPPEQRRKKLQQRIDELNREL 360
           ASKQESGKMDAKTTVGKAKGKLWLFGKKPKGPALEDFSHLPPEQRRKKLQQRIDELNREL
Sbjct: 301 ASKQESGKMDAKTTVGKAKGKLWLFGKKPKGPALEDFSHLPPEQRRKKLQQRIDELNREL 360

Query: 361 QKESDQKDALNKMKDVYEKNPQMGDPGSLQPKLAETMNNIDRLRMEIHKNEAWLSEVEGK 420
           QKESDQKDALNKMKDVYEKNPQMGDPGSLQPKLAETMNNIDRLRMEIHKNEAWLSEVEGK
Sbjct: 361 QKESDQKDALNKMKDVYEKNPQMGDPGSLQPKLAETMNNIDRLRMEIHKNEAWLSEVEGK 420

Query: 421 TGGRGDRRHSSDINHLVTQGRESPEGSYTDDANQEVRGPPQQHGHHNEFDDEFEDDDPLP 480
           TGGRGDRRHSSDINHLVTQGRESPEGSYTDDANQEVRGPPQQHGHHNEFDDEFEDDDPLP
Sbjct: 421 TGGRGDRRHSSDINHLVTQGRESPEGSYTDDANQEVRGPPQQHGHHNEFDDEFEDDDPLP 480

Query: 481 AIGHCKAIYPFDGHNEGTLAMKEGEVLYIIEEDKGDGWTRARRQNGEEGYVPTSYIDVTL 540
           AIGHCKAIYPFDGHNEGTLAMKEGEVLYIIEEDKGDGWTRARRQNGEEGYVPTSYIDVTL
Sbjct: 481 AIGHCKAIYPFDGHNEGTLAMKEGEVLYIIEEDKGDGWTRARRQNGEEGYVPTSYIDVTL 540

Query: 541 EKNSKGS 547
           EKNSKG+
Sbjct: 541 EKNSKGA 547


>gi|38524622 formin binding protein 1 [Homo sapiens]
          Length = 617

 Score =  610 bits (1573), Expect = e-174
 Identities = 310/624 (49%), Positives = 426/624 (68%), Gaps = 84/624 (13%)

Query: 1   MSWGTELWDQFDSLDKHTQWGIDFLERYAKFVKERIEIEQNYAKQLRNLVKKYCPKRSSK 60
           MSWGTELWDQFD+L+KHTQWGID LE+Y KFVKER EIE +YAKQLRNL KKY PK++SK
Sbjct: 1   MSWGTELWDQFDNLEKHTQWGIDILEKYIKFVKERTEIELSYAKQLRNLSKKYQPKKNSK 60

Query: 61  DEEP-RFTSCVAFFNILNELNDYAGQREVVAEEMAHRVYGELMRYAHDLKTERKMHLQEG 119
           +EE  ++TSC AF + LNE+NDYAGQ EV++E MA ++  +L RY  +LK ERK +  +G
Sbjct: 61  EEEEYKYTSCKAFISNLNEMNDYAGQHEVISENMASQIIVDLARYVQELKQERKSNFHDG 120

Query: 120 RKAQQYLDMCWKQMDNSKKKFERECREAEKAQQSYERLDNDTNATKADVEKAKQQLNLRT 179
           RKAQQ+++ CWKQ+++SK++FER+C+EA++AQQ +E++D D N TKADVEKA+QQ  +R 
Sbjct: 121 RKAQQHIETCWKQLESSKRRFERDCKEADRAQQYFEKMDADINVTKADVEKARQQAQIRH 180

Query: 180 HMADENKNEYAAQLQNFNGEQHKHFYVVIPQIYKQLQEMDERRTIKLSECYRGFADSERK 239
            MA+++K +Y++ LQ FN EQH++++  IP I++++QEM+ERR +++ E  + +A+ +R+
Sbjct: 181 QMAEDSKADYSSILQKFNHEQHEYYHTHIPNIFQKIQEMEERRIVRMGESMKTYAEVDRQ 240

Query: 240 VIPIISKCLEGMILAAKSVDERRDSQMVVDSFKSGFEPPGDFPFEDYSQHIYRTISDGTI 299
           VIPII KCL+G++ AA+S+D++ DSQ+V++++KSGFEPPGD  FEDY+Q + RT+SD ++
Sbjct: 241 VIPIIGKCLDGIVKAAESIDQKNDSQLVIEAYKSGFEPPGDIEFEDYTQPMKRTVSDNSL 300

Query: 300 SASKQESGKMDAKTTVGKAKGKLWLFGKKPKGPALEDFSHLP------------------ 341
           S S+ E GK D K   GK+KGKLW F KK K  +L    H P                  
Sbjct: 301 SNSRGE-GKPDLKFG-GKSKGKLWPFIKKNKLMSLLTSPHQPPPPPPASASPSAVPNGPQ 358

Query: 342 -PEQRRKKLQQRIDE--------------------------------------------- 355
            P+Q+++ L  R +E                                             
Sbjct: 359 SPKQQKEPLSHRFNEFMTSKPKIHCFRSLKRGLSLKLGATPEDFSNLPPEQRRKKLQQKV 418

Query: 356 --LNRELQKESDQKDALNKMKDVYEKNPQMGDPGSLQPKLAETMNNIDRLRMEIHKNEAW 413
             LN+E+QKE DQ+DA+ KMKDVY KNPQMGDP SL  KLAE   NI++LR+E  K EAW
Sbjct: 419 DELNKEIQKEMDQRDAITKMKDVYLKNPQMGDPASLDHKLAEVSQNIEKLRVETQKFEAW 478

Query: 414 LSEVEGKTGGRG----------DRRHSSDINHLVTQGRESPEGSYTDDANQEVRGPPQQH 463
           L+EVEG+   R           D ++   +N+   Q RESP+GSYT++ +QE     +  
Sbjct: 479 LAEVEGRLPARSEQARRQSGLYDSQNPPTVNN-CAQDRESPDGSYTEEQSQE----SEMK 533

Query: 464 GHHNEFDDEFEDDDPLPAIGHCKAIYPFDGHNEGTLAMKEGEVLYIIEEDKGDGWTRARR 523
               +FDDEF+D++PLPAIG CKA+Y F+G NEGT+++ EGE LY+IEEDKGDGWTR RR
Sbjct: 534 VLATDFDDEFDDEEPLPAIGTCKALYTFEGQNEGTISVVEGETLYVIEEDKGDGWTRIRR 593

Query: 524 QNGEEGYVPTSYIDVTLEKNSKGS 547
              EEGYVPTSY++V L+KN+K S
Sbjct: 594 NEDEEGYVPTSYVEVCLDKNAKDS 617


>gi|11342676 thyroid hormone receptor interactor 10 [Homo sapiens]
          Length = 545

 Score =  601 bits (1549), Expect = e-172
 Identities = 300/548 (54%), Positives = 402/548 (73%), Gaps = 12/548 (2%)

Query: 1   MSWGTELWDQFDSLDKHTQWGIDFLERYAKFVKERIEIEQNYAKQLRNLVKKYCPKRSSK 60
           M WGTELWDQF+ L++HTQWG+D L+RY KFVKER E+EQ YAKQLR+LVKKY PKR +K
Sbjct: 1   MDWGTELWDQFEVLERHTQWGLDLLDRYVKFVKERTEVEQAYAKQLRSLVKKYLPKRPAK 60

Query: 61  DE-EPRFTSCVAFFNILNELNDYAGQREVVAEEMAHRVYGELMRYAHDLKTERKMHLQEG 119
           D+ E +F+   +F  IL E+ND+AGQRE+VAE ++ RV  EL +Y+ ++K ERKMH QEG
Sbjct: 61  DDPESKFSQQQSFVQILQEVNDFAGQRELVAENLSVRVCLELTKYSQEMKQERKMHFQEG 120

Query: 120 RKAQQYLDMCWKQMDNSKKKFERECREAEKAQQSYERLDNDTNATKADVEKAKQQLNLRT 179
           R+AQQ L+  +KQ++NSK+KFER+CREAEKA Q+ ERLD D NATKADVEKAKQQ +LR+
Sbjct: 121 RRAQQQLENGFKQLENSKRKFERDCREAEKAAQTAERLDQDINATKADVEKAKQQAHLRS 180

Query: 180 HMADENKNEYAAQLQNFNGEQHKHFYVVIPQIYKQLQEMDERRTIKLSECYRGFADSERK 239
           HMA+E+KNEYAAQLQ FN +Q   ++  +PQI+ +LQ+MDERR  +L   Y   +++E +
Sbjct: 181 HMAEESKNEYAAQLQRFNRDQAHFYFSQMPQIFDKLQDMDERRATRLGAGYGLLSEAELE 240

Query: 240 VIPIISKCLEGMILAAKSVDERRDSQMVVDSFKSGFEPPGDFPFEDYSQHIYRTISDGTI 299
           V+PII+KCLEGM +AA +VD + DS ++++  KSGF  PGD  FED+SQ + R  SD ++
Sbjct: 241 VVPIIAKCLEGMKVAANAVDPKNDSHVLIELHKSGFARPGDVEFEDFSQPMNRAPSDSSL 300

Query: 300 SASKQESGKMDAKTTVGKAKGKLWLFGKKPKGPALEDFSHLPPEQRRKKLQQRIDELNRE 359
                   ++      G+++ K W FGKK K    EDFSHLPPEQ+RK+LQQ+++E +RE
Sbjct: 301 GTPSDGRPELRGP---GRSRTKRWPFGKKNKTVVTEDFSHLPPEQQRKRLQQQLEERSRE 357

Query: 360 LQKESDQKDALNKMKDVYEKNPQMGDPGSLQPKLAETMNNIDRLRMEIHKNEAWLSEVEG 419
           LQKE DQ++AL KMKDVYEK PQMGDP SL+P++AET++NI+RL++E+ K EAWL+E E 
Sbjct: 358 LQKEVDQREALKKMKDVYEKTPQMGDPASLEPQIAETLSNIERLKLEVQKYEAWLAEAES 417

Query: 420 KT-GGRGD--RRHSSDINHLVTQGRESPEGSYTDDANQEVRGPPQQHGH----HNEFDDE 472
           +    RGD   RH+   +   +   +S   S + D  +    PP +       + EFD++
Sbjct: 418 RVLSNRGDSLSRHARPPDPPASAPPDSSSNSASQDTKESSEEPPSEESQDTPIYTEFDED 477

Query: 473 FEDDDPLPAIGHCKAIYPFDGHNEGTLAMKEGEVLYIIEEDKGDGWTRARRQNGEEGYVP 532
           FE ++P   IGHC AIY F+G +EGT++M EGE L ++EEDKGDGWTR RR+ G EGYVP
Sbjct: 478 FE-EEPTSPIGHCVAIYHFEGSSEGTISMAEGEDLSLMEEDKGDGWTRVRRKEGGEGYVP 536

Query: 533 TSYIDVTL 540
           TSY+ VTL
Sbjct: 537 TSYLRVTL 544


>gi|182765466 FCH and double SH3 domains 2 [Homo sapiens]
          Length = 740

 Score = 80.9 bits (198), Expect = 3e-15
 Identities = 121/548 (22%), Positives = 206/548 (37%), Gaps = 62/548 (11%)

Query: 9   DQFDSLDKHTQWGIDFLERYAKFVKERIEIEQNYAKQLRNLVKKYC----PKRSSKDEEP 64
           +Q   L    Q   D LE    F +++  IE+ YA+ ++ L  +Y     P   + D   
Sbjct: 20  EQMTKLQAKHQAECDLLEDMRTFSQKKAAIEREYAQGMQKLASQYLKRDWPGVKADDRND 79

Query: 65  RFTSCVAFFNILNELNDYAGQREVVAEEMAHRVYGELMRYAHDLKTER-KMHLQEGRKAQ 123
             +    + + L      A  R  + E   + +  E  R    LK ++ K  + +  K Q
Sbjct: 80  YRSMYPVWKSFLEGTMQVAQSRMNICENYKNFI-SEPARTVRSLKEQQLKRCVDQLTKIQ 138

Query: 124 QYLDMCWKQMDNSKKK-FERECREAEKAQQSYERLDNDTNA------TKADVEKAKQQLN 176
             L    K +   KKK FE E    + A    E+ D +  +      ++  ++KA  +L 
Sbjct: 139 TELQETVKDLAKGKKKYFETE----QMAHAVREKADIEAKSKLSLFQSRISLQKASVKLK 194

Query: 177 LR----THMADENKNEYAAQLQNFNGEQHKHFYVVIPQIYKQLQEMDERRTIKLSECYRG 232
            R       A   +N+Y   L   N  Q +++   +  I K L   D      L +    
Sbjct: 195 ARRSECNSKATHARNDYLLTLAAANAHQDRYYQTDLVNIMKAL---DGNVYDHLKDYLIA 251

Query: 233 FADSERKVIPIISKCLEGMILAAKSVDERRDSQMVVDSFKSGFEPPGDFPFEDYSQHIYR 292
           F+ +E +    +    + ++  +  V    + Q+ +    + F  P  F F+       R
Sbjct: 252 FSRTELETCQAVQNTFQFLLENSSKVVRDYNLQLFLQE-NAVFHKPQPFQFQPCDSDTSR 310

Query: 293 TISDGTISASKQESGKMDAKTTVGKAKGKLWLFGKKPKGPALEDFSHLPPEQRRKKLQQR 352
            +   T +  +    K   K     A+    +  ++     LE       EQ R +L+Q+
Sbjct: 311 QLESETGTTEEHSLNKEARKWATRVAREHKNIVHQQRVLNDLECHGAAVSEQSRAELEQK 370

Query: 353 IDELNRELQKESDQKDALNKMKDVYEKNPQMGDPGSLQPKLAETMNNIDRLRMEIHKNEA 412
           IDE    ++K    K       D+ +   Q+G   S+   L   MN +    ME  +NE 
Sbjct: 371 IDEARENIRKAEIIKLKAEARLDLLK---QIGV--SVDTWLKSAMNQV----MEELENER 421

Query: 413 WLSEVEGKTGGRGDRRHSSDINHLVTQGRESPEGSYTDDANQEVRGPPQQHGHHNEFDDE 472
           W          R     S+   H +    E  EG   +D N +V            FDD 
Sbjct: 422 W---------ARPPAVTSNGTLHSLNADTEREEGEEFED-NMDV------------FDDS 459

Query: 473 FEDDDPLPAIGH----CKAIYPFDGHNEGTLAMKEGEVLYIIEEDKGDGWTRARRQNGEE 528
                P   + +    CK +Y +       L ++E EVL +IE+   + W +AR + G+ 
Sbjct: 460 --SSSPSGTLRNYPLTCKVVYSYKASQPDELTIEEHEVLEVIEDGDMEDWVKARNKVGQV 517

Query: 529 GYVPTSYI 536
           GYVP  Y+
Sbjct: 518 GYVPEKYL 525


>gi|112363100 SLIT-ROBO Rho GTPase activating protein 2 isoform a
           [Homo sapiens]
          Length = 1071

 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 64/324 (19%), Positives = 140/324 (43%), Gaps = 45/324 (13%)

Query: 6   ELWDQFDSLDKHTQWGIDFLERYAKFVKERIEIEQNYAKQLRNLVKKYCPK-RSSKDE-- 62
           +L +Q   LD+  +  +  L+    F +++ EIE +Y++ L  L +++  K RS+KD+  
Sbjct: 27  QLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIEMDYSRNLEKLAERFLAKTRSTKDQQF 86

Query: 63  --EPRFTSCVAFFNIL--------------------------NELNDYAGQREVVAEEMA 94
             +    S V  +N+L                           ++++ +G+    ++E+ 
Sbjct: 87  KKDQNVLSPVNCWNLLLNQVKRESRDHTTLSDIYLNNIIPRFVQVSEDSGRLFKKSKEVG 146

Query: 95  HRVYGELMRYAHDLKTERK---MHLQEGRKAQQYLDMCWKQMDNS-KKKFERECREAEKA 150
            ++  +LM+  ++L +  K   M+  +   AQ  L    KQ +    K  ++E R+  ++
Sbjct: 147 QQLQDDLMKVLNELYSVMKTYHMYNADSISAQSKLKEAEKQEEKQIGKSVKQEDRQTPRS 206

Query: 151 QQSYERLD-NDTNATKADVEKAKQQLNLRTHMADENK-------NEYAAQLQNFNGEQHK 202
             S   +   + +  ++ V+K ++    R     ENK       NEY   L+  N    K
Sbjct: 207 PDSTANVRIEEKHVRRSSVKKIEKMKEKRQAKYTENKLKAIKARNEYLLALEATNASVFK 266

Query: 203 HFYVVIPQIYKQLQEMDERRTIKLSECYRGFADSERKVIPIISKCLEGMILAAKSVDERR 262
           ++   +  +  Q  ++    +  L+   R F  +E  +     + L+ +  A +++D   
Sbjct: 267 YYIHDLSDLIDQCCDLGYHAS--LNRALRTFLSAELNLEQSKHEGLDAIENAVENLDATS 324

Query: 263 DSQMVVDSFKSGFEPPGDFPFEDY 286
           D Q +++ + + F PP  F F+ +
Sbjct: 325 DKQRLMEMYNNVFCPPMKFEFQPH 348


>gi|112363096 SLIT-ROBO Rho GTPase activating protein 2 isoform b
           [Homo sapiens]
          Length = 836

 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 64/324 (19%), Positives = 140/324 (43%), Gaps = 45/324 (13%)

Query: 6   ELWDQFDSLDKHTQWGIDFLERYAKFVKERIEIEQNYAKQLRNLVKKYCPK-RSSKDE-- 62
           +L +Q   LD+  +  +  L+    F +++ EIE +Y++ L  L +++  K RS+KD+  
Sbjct: 27  QLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIEMDYSRNLEKLAERFLAKTRSTKDQQF 86

Query: 63  --EPRFTSCVAFFNIL--------------------------NELNDYAGQREVVAEEMA 94
             +    S V  +N+L                           ++++ +G+    ++E+ 
Sbjct: 87  KKDQNVLSPVNCWNLLLNQVKRESRDHTTLSDIYLNNIIPRFVQVSEDSGRLFKKSKEVG 146

Query: 95  HRVYGELMRYAHDLKTERK---MHLQEGRKAQQYLDMCWKQMDNS-KKKFERECREAEKA 150
            ++  +LM+  ++L +  K   M+  +   AQ  L    KQ +    K  ++E R+  ++
Sbjct: 147 QQLQDDLMKVLNELYSVMKTYHMYNADSISAQSKLKEAEKQEEKQIGKSVKQEDRQTPRS 206

Query: 151 QQSYERLD-NDTNATKADVEKAKQQLNLRTHMADENK-------NEYAAQLQNFNGEQHK 202
             S   +   + +  ++ V+K ++    R     ENK       NEY   L+  N    K
Sbjct: 207 PDSTANVRIEEKHVRRSSVKKIEKMKEKRQAKYTENKLKAIKARNEYLLALEATNASVFK 266

Query: 203 HFYVVIPQIYKQLQEMDERRTIKLSECYRGFADSERKVIPIISKCLEGMILAAKSVDERR 262
           ++   +  +  Q  ++    +  L+   R F  +E  +     + L+ +  A +++D   
Sbjct: 267 YYIHDLSDLIDQCCDLGYHAS--LNRALRTFLSAELNLEQSKHEGLDAIENAVENLDATS 324

Query: 263 DSQMVVDSFKSGFEPPGDFPFEDY 286
           D Q +++ + + F PP  F F+ +
Sbjct: 325 DKQRLMEMYNNVFCPPMKFEFQPH 348


>gi|20149528 proline-serine-threonine phosphatase interacting
           protein 1 [Homo sapiens]
          Length = 416

 Score = 57.4 bits (137), Expect = 3e-08
 Identities = 56/260 (21%), Positives = 106/260 (40%), Gaps = 16/260 (6%)

Query: 30  KFVKERIEIEQNYAKQLRNLVKKYCPKRSSKDEEPRFTSCVAFFNILNELNDYAGQREVV 89
           + +++R + E+ Y K+L  + +K          +    S  A F+ L +  +  G   + 
Sbjct: 41  ELLRQRAQAEERYGKELVQIARK-------AGGQTEINSLRASFDSLKQQMENVGSSHIQ 93

Query: 90  AEEMAHRVYGELMRYAHDLKTERKMHLQEGRKAQQYLDMCWKQMDNSKKKFERECREAEK 149
                      L  +    K +RK +     + Q+     +K+   SKK +E++CR+A+ 
Sbjct: 94  LALTLREELRSLEEFRERQKEQRKKYEAVMDRVQKSKLSLYKKAMESKKTYEQKCRDADD 153

Query: 150 AQQSYERLDNDTNATKADVEKAKQQLNLRTHMADENKNEY---AAQLQNFNGEQHKHFYV 206
           A+Q++ER+    N  +  VEK++ +       A E +  Y    AQL+    E  +    
Sbjct: 154 AEQAFERI--SANGHQKQVEKSQNKARQCKDSATEAERVYRQSIAQLEKVRAEWEQEHRT 211

Query: 207 VIPQIYKQLQEMDERRTIKLSECYRGFADSERKVIPIISKCLEGMILAAKSVDERRDSQM 266
                  QLQE D R TI  +  +        + +    +  E + L  +      D   
Sbjct: 212 TCEAF--QLQEFD-RLTILRNALWVHSNQLSMQCVK-DDELYEEVRLTLEGCSIDADIDS 267

Query: 267 VVDSFKSGFEPPGDFPFEDY 286
            + +  +G EPP   P+++Y
Sbjct: 268 FIQAKSTGTEPPAPVPYQNY 287



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 32/101 (31%), Positives = 48/101 (47%), Gaps = 20/101 (19%)

Query: 437 VTQGRESPEGSYTDDANQEVRGPPQQHGHHNEFDDEFEDDDPLPAIGHCKAIYPFDGHNE 496
           +T   E  EG YT  A QE++G P                   PA  + +A+Y +   N 
Sbjct: 334 LTPTPERNEGVYTAIAVQEIQGNPAS-----------------PAQEY-RALYDYTAQNP 375

Query: 497 GTLAMKEGEVLYIIEEDKGDGWTRARRQNGEEGYVPTSYID 537
             L +  G++L +I E + DGW    R NG+ G+VP SY++
Sbjct: 376 DELDLSAGDILEVILEGE-DGWWTVER-NGQRGFVPGSYLE 414


>gi|28875786 FCH and double SH3 domains 1 [Homo sapiens]
          Length = 690

 Score = 57.0 bits (136), Expect = 4e-08
 Identities = 112/571 (19%), Positives = 214/571 (37%), Gaps = 84/571 (14%)

Query: 9   DQFDSLDKHTQWGIDFLERYAKFVKERIEIEQNYAKQLRNLVKKYCPKRSSKDEE--PRF 66
           +Q   L    Q   D LE    + K+R  IE+ Y + L+ L   +  +   +  E   R 
Sbjct: 20  EQLSILQTWQQREADLLEDIRSYSKQRAAIEREYGQALQKLAGPFLKREGHRSGEMDSRG 79

Query: 67  TSCVAFFNILNELNDYAGQREVVAEEMAHRVYGELMRYAHDLKTERKMHLQEGRKAQQYL 126
            +    +  L +     GQ  + A +    + G   R A +    +    +  ++AQ  +
Sbjct: 80  RTVFGAWRCLLDATVAGGQTRLQASDRYRDLAGGTGRSAKEQVLRKGT--ENLQRAQAEV 137

Query: 127 DMCWKQMDNSKKKFERECR-------EAEKAQQSYERLDNDTNATKADVEKAKQQLNLRT 179
               +++  S+K + +  R       +A   Q    R D+    ++  ++K   +L+ ++
Sbjct: 138 LQSVRELSRSRKLYGQRERVWALAQEKAADVQARLNRSDHGIFHSRTSLQKLSTKLSAQS 197

Query: 180 HMADEN----KNEYAAQLQNFNGEQHKHFYVVIPQIYKQL-QEMDERRTIKLSECYRGFA 234
               +     +NEY   L   N     ++   +P + K L  E+ E     L +     +
Sbjct: 198 AQYSQQLQAARNEYLLNLVATNAHLDHYYQEELPALLKALVSELSEH----LRDPLTSLS 253

Query: 235 DSERKVIPIISKCLEGMILAAKSVDERRDSQMVVDSFKSGFEPPGDFPFEDYSQHIYRTI 294
            +E +   +I +           V   +D ++ +      F P     F+          
Sbjct: 254 HTELEAAEVILEHAHRGEQTTSQVSWEQDLKLFLQE-PGVFSPTPPQQFQPA-------- 304

Query: 295 SDGTISASKQESGKMDAKTTVGKAKGKLWLFGKKPKGPALEDFSHLPPEQRRKKLQQRID 354
             GT      E G   A+   GK+               LE           K++Q+   
Sbjct: 305 --GTDQVCVLEWG---AEGVAGKS--------------GLE-----------KEVQRLTS 334

Query: 355 ELNRELQKESDQKDALNKMKDVYEKNPQMGDPGSLQPKLAETMNNIDRLRMEIHKNEAWL 414
              R+ + ++     L +++   ++  +   P S++ +L E   +I R ++   K  A L
Sbjct: 335 RAARDYKIQNHGHRVLQRLEQRRQQASEREAP-SIEQRLQEVRESIRRAQVSQVKGAARL 393

Query: 415 SEVEGK--TGGRGDRRHSSDINHLVTQGRESPEGSYTDDANQEVRGPPQQHGHHNEFDD- 471
           + ++G      R  +   +     V Q R   E   +    Q    P  +    ++F++ 
Sbjct: 394 ALLQGAGLDVERWLKPAMTQAQDEVEQERRLSEARLS----QRDLSPTAEDAELSDFEEC 449

Query: 472 -----EFEDDDP-------LPAIGHCKAIYPFDGHNEGTLAMKEGEVLYIIEEDKGDGWT 519
                 FE+  P       LP   H   ++ +    E  L + EGE L +IEE   D W 
Sbjct: 450 EETGELFEEPAPQALATRALPCPAH--VVFRYQAGREDELTITEGEWLEVIEEGDADEWV 507

Query: 520 RARRQNGEEGYVPTSYI---DVTLEKNSKGS 547
           +AR Q+GE G+VP  Y+   D++L ++S+ S
Sbjct: 508 KARNQHGEVGFVPERYLNFPDLSLPESSQDS 538


>gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]
          Length = 822

 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 67/383 (17%), Positives = 156/383 (40%), Gaps = 28/383 (7%)

Query: 1   MSWGTELWDQFDSLDKHTQWGIDFLERYAKFVKERIEIEQNYAKQLRNLVKKYCPKRSSK 60
           M +G++L +  +++ K   W +  LE   KF+  RI+ ++ YA  L+NL  +   K S+ 
Sbjct: 1   MGFGSDLKNSHEAVLKLQDWELRLLETVKKFMALRIKSDKEYASTLQNLCNQ-VDKESTV 59

Query: 61  DEEPRFTSCVAFFNILNELNDYAGQREVVAEEMAHRVYGELMRYAHDLKTERKMHLQEGR 120
                     ++  ++ +    +   +  AE++       L     D +  +K ++   +
Sbjct: 60  QMNYVSNVSKSWLLMIQQTEQLSRIMKTHAEDLNSGPLHRLTMMIKDKQQVKKSYIGVHQ 119

Query: 121 KAQ-QYLDMCWKQMDNSKKKFERECREAEKAQQSYERLDNDTNATKADVEKAKQQLNLRT 179
           + + + + +   +++  K  + +  +E   A++ Y+    +  A   + EKAK++ +  T
Sbjct: 120 QIEAEMIKVTKTELEKLKCSYRQLIKEMNSAKEKYK----EALAKGKETEKAKERYDKAT 175

Query: 180 HMADENKNEYAAQLQNFNGEQHKHFYVVIPQIYKQLQEMDERRTIKLSECYRGFADSERK 239
                  N+Y   L+     Q++++ + +P +   LQ+M E     L   +  ++     
Sbjct: 176 MKLHMLHNQYVLALKGAQLHQNQYYDITLPLLLDSLQKMQEEMIKALKGIFDEYSQITSL 235

Query: 240 VIPIISKCLEGMILAAKSVDERRDSQMVVDSFKSGFEPPGDFPFEDYSQHIYRTISDGTI 299
           V   I    + + ++ + +D   +    +D  ++      +  F+         +    I
Sbjct: 236 VTEEIVNVHKEIQMSVEQIDPSTEYNNFIDVHRTTAAKEQEIEFDTSLLEENENLQANEI 295

Query: 300 SASK--QESGKMDAKTTVGKAKGKLWLFGKKPKGPALEDFSHLPPEQRRKKLQQRIDELN 357
             +    ES ++  KT   +      +               L  E+   +L++RI+E +
Sbjct: 296 MWNNLTAESLQVMLKTLAEELMQTQQML--------------LNKEEAVLELEKRIEESS 341

Query: 358 RELQKESD------QKDALNKMK 374
              +K+SD      QK AL ++K
Sbjct: 342 ETCEKKSDIVLLLSQKQALEELK 364


>gi|44917604 SLIT-ROBO Rho GTPase activating protein 1 [Homo
           sapiens]
          Length = 1085

 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 60/315 (19%), Positives = 131/315 (41%), Gaps = 38/315 (12%)

Query: 6   ELWDQFDSLDKHTQWGIDFLERYAKFVKERIEIEQNYAKQLRNLVKKYCPK-RSSKD--- 61
           +L +Q   L++ T+  +  L+    F +++ EIE  Y++ L  L +++  K RS+KD   
Sbjct: 27  QLVEQQKCLEQQTEMRVQLLQDLQDFFRKKAEIETEYSRNLEKLAERFMAKTRSTKDHQQ 86

Query: 62  ---EEPRFTSCVAFFNILNELNDYAGQREVVAEEMAHRVYGELMRYAHD----LKTERKM 114
              ++   +    ++ +LN++   +     +++   + V    M+ + D     K  +++
Sbjct: 87  YKKDQNLLSPVNCWYLLLNQVRRESKDHATLSDIYLNNVIMRFMQISEDSTRMFKKSKEI 146

Query: 115 HLQEGRKAQQYLDMCWKQMDN------SKKKFERECREAEKAQQS----------YERLD 158
             Q      + L+  +  M             E + +EAEK ++           + RL+
Sbjct: 147 AFQLHEDLMKVLNELYTVMKTYHMYHAESISAESKLKEAEKQEEKQIGRSGDPVFHIRLE 206

Query: 159 NDTNATKADVEKAKQQLNLRTHMADENK-------NEYAAQLQNFNGEQHKHFYVVIPQI 211
            + +  ++ V+K ++    R     ENK       NEY   L+  N    K++   I  +
Sbjct: 207 -ERHQRRSSVKKIEKMKEKRQAKYSENKLKSIKARNEYLLTLEATNASVFKYY---IHDL 262

Query: 212 YKQLQEMDERRTIKLSECYRGFADSERKVIPIISKCLEGMILAAKSVDERRDSQMVVDSF 271
              +   D      L+   R +  +E  +     + L+ +  A  +++ R D Q  ++ +
Sbjct: 263 SDLIDCCDLGYHASLNRALRTYLSAEYNLETSRHEGLDIIENAVDNLEPRSDKQRFMEMY 322

Query: 272 KSGFEPPGDFPFEDY 286
            + F PP  F F+ +
Sbjct: 323 PAAFCPPMKFEFQSH 337



 Score = 32.3 bits (72), Expect = 1.1
 Identities = 27/88 (30%), Positives = 39/88 (44%), Gaps = 14/88 (15%)

Query: 459 PPQQHGHHNEFDDEF-------EDD-DPLPAIGHCKAIYPFDGHNEGTLAMKEGEVLYII 510
           P  +HG   E D +        ED+ +P+ AI    A + + G +   L+ K+G  L + 
Sbjct: 718 PYSEHGTLEEVDQDAGTEPHTSEDECEPIEAI----AKFDYVGRSARELSFKKGASLLLY 773

Query: 511 EEDKGDGWTRARRQNGEEGYVPTSYIDV 538
                D W    R NG +G VP  YI V
Sbjct: 774 HRASEDWWEG--RHNGIDGLVPHQYIVV 799


>gi|189491776 nephrocystin 1 isoform 3 [Homo sapiens]
          Length = 677

 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 45/199 (22%), Positives = 84/199 (42%), Gaps = 10/199 (5%)

Query: 344 QRRKKLQQRIDELNRELQKESDQKDAL--NKMKDVYEKNPQMGDPGSLQPKLAETMNNID 401
           +R ++L+Q++D L      ES  K+AL  NK + +Y++  Q+           + ++  D
Sbjct: 15  RRNQELKQQVDSL----LSESQLKEALEPNKRQHIYQRCIQLKQAIDENKNALQKLSKAD 70

Query: 402 RLRMEIHKNEAWLSE---VEGKTGGRGDRRHSSDINHLVTQGRESPEGSYTDDANQEVRG 458
                 + N+    E   ++  T        +    ++   G  + E   ++  + E  G
Sbjct: 71  ESAPVANYNQRKEEEHTLLDKLTQQLQGLAVTISRENITEVGAPTEEEEESESEDSEDSG 130

Query: 459 PPQQHGHHNEFDDEFEDDDPLPAIGHCKAIYPFDGHNEGTLAMKEGEVLYIIEEDKGDGW 518
             ++     E + E  +           A+  F     G L  K+GE+L +IE+ K DGW
Sbjct: 131 GEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILLVIEK-KPDGW 189

Query: 519 TRARRQNGEEGYVPTSYID 537
             A+   G EG VP +Y++
Sbjct: 190 WIAKDAKGNEGLVPRTYLE 208


>gi|189491774 nephrocystin 1 isoform 2 [Homo sapiens]
          Length = 732

 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 45/199 (22%), Positives = 84/199 (42%), Gaps = 10/199 (5%)

Query: 344 QRRKKLQQRIDELNRELQKESDQKDAL--NKMKDVYEKNPQMGDPGSLQPKLAETMNNID 401
           +R ++L+Q++D L      ES  K+AL  NK + +Y++  Q+           + ++  D
Sbjct: 15  RRNQELKQQVDSL----LSESQLKEALEPNKRQHIYQRCIQLKQAIDENKNALQKLSKAD 70

Query: 402 RLRMEIHKNEAWLSE---VEGKTGGRGDRRHSSDINHLVTQGRESPEGSYTDDANQEVRG 458
                 + N+    E   ++  T        +    ++   G  + E   ++  + E  G
Sbjct: 71  ESAPVANYNQRKEEEHTLLDKLTQQLQGLAVTISRENITEVGAPTEEEEESESEDSEDSG 130

Query: 459 PPQQHGHHNEFDDEFEDDDPLPAIGHCKAIYPFDGHNEGTLAMKEGEVLYIIEEDKGDGW 518
             ++     E + E  +           A+  F     G L  K+GE+L +IE+ K DGW
Sbjct: 131 GEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILLVIEK-KPDGW 189

Query: 519 TRARRQNGEEGYVPTSYID 537
             A+   G EG VP +Y++
Sbjct: 190 WIAKDAKGNEGLVPRTYLE 208


>gi|46397398 nephrocystin 1 isoform 1 [Homo sapiens]
          Length = 733

 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 45/199 (22%), Positives = 84/199 (42%), Gaps = 10/199 (5%)

Query: 344 QRRKKLQQRIDELNRELQKESDQKDAL--NKMKDVYEKNPQMGDPGSLQPKLAETMNNID 401
           +R ++L+Q++D L      ES  K+AL  NK + +Y++  Q+           + ++  D
Sbjct: 15  RRNQELKQQVDSL----LSESQLKEALEPNKRQHIYQRCIQLKQAIDENKNALQKLSKAD 70

Query: 402 RLRMEIHKNEAWLSE---VEGKTGGRGDRRHSSDINHLVTQGRESPEGSYTDDANQEVRG 458
                 + N+    E   ++  T        +    ++   G  + E   ++  + E  G
Sbjct: 71  ESAPVANYNQRKEEEHTLLDKLTQQLQGLAVTISRENITEVGAPTEEEEESESEDSEDSG 130

Query: 459 PPQQHGHHNEFDDEFEDDDPLPAIGHCKAIYPFDGHNEGTLAMKEGEVLYIIEEDKGDGW 518
             ++     E + E  +           A+  F     G L  K+GE+L +IE+ K DGW
Sbjct: 131 GEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILLVIEK-KPDGW 189

Query: 519 TRARRQNGEEGYVPTSYID 537
             A+   G EG VP +Y++
Sbjct: 190 WIAKDAKGNEGLVPRTYLE 208


>gi|24308229 protein kinase C and casein kinase substrate in neurons
           1 [Homo sapiens]
          Length = 444

 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 98/514 (19%), Positives = 184/514 (35%), Gaps = 125/514 (24%)

Query: 32  VKERIEIEQNYAKQLRNLVKKYCPKRSSKDEEPRFTSCVAFFNILNELNDYAGQREVVAE 91
           V+ER +IE+ Y +QL +  K++   R   ++ P++ S                       
Sbjct: 46  VQERAKIEKAYGQQLTDWAKRW---RQLIEKGPQYGSL---------------------- 80

Query: 92  EMAHRVYGELMRYAH---DLKTERKMHL--QEGRKAQQYLDMCWKQMDNSKKKFERECRE 146
               R +G +M  A    +L  E K +L  ++  K + +      Q D   K+     +E
Sbjct: 81  ---ERAWGAIMTEADKVSELHQEVKNNLLNEDLEKVKNW------QKDAYHKQIMGGFKE 131

Query: 147 AEKAQQSYERLDNDTNATKADVEKAKQQLNLRTHMADENKNEYAAQLQNFNGEQHKHFYV 206
            ++A+  + +          ++E AK+  +L        K E  A  +  N +  +    
Sbjct: 132 TKEAEDGFRKAQKPWAKKMKELEAAKKAYHLAC------KEEKLAMTREMNSKTEQS--- 182

Query: 207 VIPQIYKQLQEMDER---RTIKLSECYRGFADSERKVIPIISKCLEGMILAAKSVDERRD 263
           V P+  K+LQ+  ++      K  E Y    +   K  P   + +E +    +  +E+R 
Sbjct: 183 VTPEQQKKLQDKVDKCKQDVQKTQEKYEKVLEDVGKTTPQYMENMEQVFEQCQQFEEKR- 241

Query: 264 SQMVVDSFKSGFEPPGDFPFEDYSQHIYRTISDGTISASKQESGKMDAKTTVGKAKGKLW 323
             + +       +   +        H+YR +      A  QE  +   ++T G      W
Sbjct: 242 -LVFLKEVLLDIKRHLNLAENSSYIHVYRELEQAIRGADAQEDLRW-FRSTSGPGMPMNW 299

Query: 324 LFGKKPKGPALEDFSHLPPEQRRKKLQQRIDELNRELQKESDQKDALNKMKDVYEKNPQM 383
                   P  E+++   P    KK          E Q +  +  AL       E   Q 
Sbjct: 300 --------PQFEEWNPDLPHTTTKK----------EKQPKKAEGVALTNATGAVESTSQA 341

Query: 384 GDPGSLQPKLAETMNNIDRLRMEIHKNEAWLSEVEGKTGGRGDRRHSSDINHLVTQGRES 443
           GD GS+        ++ DR        + + +E                           
Sbjct: 342 GDRGSV--------SSYDR-------GQPYATE--------------------------- 359

Query: 444 PEGSYTDDANQEVRGPPQQHGHHNEFDDEFEDDDPLPAIGHCKAIYPFDGHNEGTLAMKE 503
               ++DD +    G  + +G  N F+D+ +           +A+Y +DG  +  L+ K 
Sbjct: 360 ----WSDDESGNPFGGSETNGGANPFEDDSKGV-------RVRALYDYDGQEQDELSFKA 408

Query: 504 GEVLYIIEEDKGDGWTRARRQNGEEGYVPTSYID 537
           G+ L  + E+   GW R R  +G+ G  P +Y++
Sbjct: 409 GDELTKLGEEDEQGWCRGRLDSGQLGLYPANYVE 442


>gi|75677374 SLIT-ROBO Rho GTPase activating protein 3 isoform b
           [Homo sapiens]
          Length = 1075

 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 63/318 (19%), Positives = 133/318 (41%), Gaps = 42/318 (13%)

Query: 5   TELWDQFDSLDKHTQWGIDFLERYAKFVKERIEIEQNYAKQLRNLVKKYCPK-RSSKDEE 63
           T+L +QF  L++ ++  +  L+   +F + + EIE  Y++ L  L +++  K RSS++ +
Sbjct: 26  TQLVEQFKCLEQQSESRLQLLQDLQEFFRRKAEIELEYSRSLEKLAERFSSKIRSSREHQ 85

Query: 64  PR-----FTSCVAFFNILNE----------LNDYAGQREVV---------------AEEM 93
            +      +    ++ +L++          LND      +V               ++E+
Sbjct: 86  FKKDQYLLSPVNCWYLVLHQTRRESRDHATLNDIFMNNVIVRLSQISEDVIRLFKKSKEI 145

Query: 94  AHRVYGELMRYAHDLKTERK---MHLQEGRKAQQYLDMCWKQMDNSKKKFERECREAEKA 150
             +++ EL++  ++L T  K   M+  E   A+  L    KQ    +K+F +    +   
Sbjct: 146 GLQMHEELLKVTNELYTVMKTYHMYHAESISAESKLKEAEKQ---EEKQFNKSGDLSMNL 202

Query: 151 QQSYERLDNDTNATKADVEKAKQQLNLRTH--MADENKNEYAAQLQNFNGEQHKHFYVVI 208
            +  +R    ++  K +  K K+Q     +     + +N+Y   L   N    K++   I
Sbjct: 203 LRHEDRPQRRSSVKKIEKMKEKRQAKYSENKLKCTKARNDYLLNLAATNAAISKYY---I 259

Query: 209 PQIYKQLQEMDERRTIKLSECYRGFADSERKVIPIISKCLEGMILAAKSVDERRDSQMVV 268
             +   +   D      L+  +R +  +E  +     + L+ +  A  ++D R D   V+
Sbjct: 260 HDVSDLIDCCDLGFHASLARTFRTYLSAEYNLETSRHEGLDVIENAVDNLDSRSDKHTVM 319

Query: 269 DSFKSGFEPPGDFPFEDY 286
           D     F PP  F F+ +
Sbjct: 320 DMCNQVFCPPLKFEFQPH 337



 Score = 31.2 bits (69), Expect = 2.6
 Identities = 26/93 (27%), Positives = 39/93 (41%), Gaps = 9/93 (9%)

Query: 448 YTDDANQEVRGPPQQHGHHNEFDDEFEDDDPLPAIGHCKAIYPFD--GHNEGTLAMKEGE 505
           Y D  + E  G   +  H N  +    D++    +   +AI  FD  G +   L+ K+G 
Sbjct: 691 YCDSPHSEP-GAIDEVDHDNGTEPHTSDEE----VEQIEAIAKFDYMGRSPRELSFKKGA 745

Query: 506 VLYIIEEDKGDGWTRARRQNGEEGYVPTSYIDV 538
            L +      D W    R NG +G +P  YI V
Sbjct: 746 SLLLYHRASEDWWEG--RHNGVDGLIPHQYIVV 776


>gi|24307967 SLIT-ROBO Rho GTPase activating protein 3 isoform a
           [Homo sapiens]
          Length = 1099

 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 63/318 (19%), Positives = 133/318 (41%), Gaps = 42/318 (13%)

Query: 5   TELWDQFDSLDKHTQWGIDFLERYAKFVKERIEIEQNYAKQLRNLVKKYCPK-RSSKDEE 63
           T+L +QF  L++ ++  +  L+   +F + + EIE  Y++ L  L +++  K RSS++ +
Sbjct: 26  TQLVEQFKCLEQQSESRLQLLQDLQEFFRRKAEIELEYSRSLEKLAERFSSKIRSSREHQ 85

Query: 64  PR-----FTSCVAFFNILNE----------LNDYAGQREVV---------------AEEM 93
            +      +    ++ +L++          LND      +V               ++E+
Sbjct: 86  FKKDQYLLSPVNCWYLVLHQTRRESRDHATLNDIFMNNVIVRLSQISEDVIRLFKKSKEI 145

Query: 94  AHRVYGELMRYAHDLKTERK---MHLQEGRKAQQYLDMCWKQMDNSKKKFERECREAEKA 150
             +++ EL++  ++L T  K   M+  E   A+  L    KQ    +K+F +    +   
Sbjct: 146 GLQMHEELLKVTNELYTVMKTYHMYHAESISAESKLKEAEKQ---EEKQFNKSGDLSMNL 202

Query: 151 QQSYERLDNDTNATKADVEKAKQQLNLRTH--MADENKNEYAAQLQNFNGEQHKHFYVVI 208
            +  +R    ++  K +  K K+Q     +     + +N+Y   L   N    K++   I
Sbjct: 203 LRHEDRPQRRSSVKKIEKMKEKRQAKYSENKLKCTKARNDYLLNLAATNAAISKYY---I 259

Query: 209 PQIYKQLQEMDERRTIKLSECYRGFADSERKVIPIISKCLEGMILAAKSVDERRDSQMVV 268
             +   +   D      L+  +R +  +E  +     + L+ +  A  ++D R D   V+
Sbjct: 260 HDVSDLIDCCDLGFHASLARTFRTYLSAEYNLETSRHEGLDVIENAVDNLDSRSDKHTVM 319

Query: 269 DSFKSGFEPPGDFPFEDY 286
           D     F PP  F F+ +
Sbjct: 320 DMCNQVFCPPLKFEFQPH 337



 Score = 31.2 bits (69), Expect = 2.6
 Identities = 26/93 (27%), Positives = 39/93 (41%), Gaps = 9/93 (9%)

Query: 448 YTDDANQEVRGPPQQHGHHNEFDDEFEDDDPLPAIGHCKAIYPFD--GHNEGTLAMKEGE 505
           Y D  + E  G   +  H N  +    D++    +   +AI  FD  G +   L+ K+G 
Sbjct: 715 YCDSPHSEP-GAIDEVDHDNGTEPHTSDEE----VEQIEAIAKFDYMGRSPRELSFKKGA 769

Query: 506 VLYIIEEDKGDGWTRARRQNGEEGYVPTSYIDV 538
            L +      D W    R NG +G +P  YI V
Sbjct: 770 SLLLYHRASEDWWEG--RHNGVDGLIPHQYIVV 800


>gi|148747351 protein kinase C and casein kinase substrate in
           neurons 2 [Homo sapiens]
          Length = 486

 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 36/158 (22%), Positives = 67/158 (42%), Gaps = 7/158 (4%)

Query: 382 QMGDPGSLQPKLAETMNNIDRLRMEIHKNEAWLS-EVEGKTGGRGDRRHSSDINHLVTQG 440
           Q GD  SL  K + T+N             ++   E E  TG     +  +   ++ +  
Sbjct: 331 QTGDQ-SLPSKPSSTLNVPSNPAQSAQSQSSYNPFEDEDDTGSTVSEKDDTKAKNVSSYE 389

Query: 441 R-ESPEGSYTDDANQEVRGPPQQHGHHNEFDDEFEDDDPLPAIGHCKAIYPFDGHNEGTL 499
           + +S    ++DD +         +G  N FDD+      +      +A+Y ++G     L
Sbjct: 390 KTQSYPTDWSDDESNNPFSSTDANGDSNPFDDDATSGTEV----RVRALYDYEGQEHDEL 445

Query: 500 AMKEGEVLYIIEEDKGDGWTRARRQNGEEGYVPTSYID 537
           + K G+ L  +E++   GW + R  NG+ G  P +Y++
Sbjct: 446 SFKAGDELTKMEDEDEQGWCKGRLDNGQVGLYPANYVE 483



 Score = 37.4 bits (85), Expect = 0.036
 Identities = 44/212 (20%), Positives = 87/212 (41%), Gaps = 33/212 (15%)

Query: 34  ERIEIEQNYAKQLRNLVKKYCPKRSSKDEEPRF-TSCVAFFNILNELNDYAGQREVVAEE 92
           ER  IE+ YA+QL    +++   R   ++ P++ T   A+   ++E    +     V   
Sbjct: 47  ERARIEKAYAQQLTEWARRW---RQLVEKGPQYGTVEKAWMAFMSEAERVSELHLEVKAS 103

Query: 93  MAHRVYGELMRYAHDLKTERKM-------HLQEG-RKAQQYLDMCWKQMDNSKKKFEREC 144
           + +  + ++  +  +   ++ M         ++G RKAQ+      K+++ +KK     C
Sbjct: 104 LMNDDFEKIKNWQKEAFHKQMMGGFKETKEAEDGFRKAQKPWAKKLKEVEAAKKAHHAAC 163

Query: 145 REAE---------------------KAQQSYERLDNDTNATKADVEKAKQQLNLRTHMAD 183
           +E +                     K Q   E+   D   TK   EK+ ++L+  T    
Sbjct: 164 KEEKLAISREANSKADPSLNPEQLKKLQDKIEKCKQDVLKTKEKYEKSLKELDQGTPQYM 223

Query: 184 ENKNEYAAQLQNFNGEQHKHFYVVIPQIYKQL 215
           EN  +   Q Q F  ++ + F  V+ ++ K L
Sbjct: 224 ENMEQVFEQCQQFEEKRLRFFREVLLEVQKHL 255


>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
          Length = 1670

 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 70/427 (16%), Positives = 172/427 (40%), Gaps = 54/427 (12%)

Query: 120 RKAQQYLDMCWKQMDNSKKKFERECREAEKAQQSYERLDNDTN-ATKADVEKAK--QQLN 176
           RK ++  +  WK+    +K+ E++ RE E+ ++   R D +   A K ++E+ +  +   
Sbjct: 406 RKQRELQEQEWKKQLELEKRLEKQ-RELERQREEERRKDIERREAAKQELERQRRLEWER 464

Query: 177 LRTHMADENKNEYAAQLQNFNGEQHKHFYVVIPQIYKQLQEMDER-RTIKLSECYRGFAD 235
           +R       KN    ++   N ++ K+ ++ +  +  + Q++  R + ++L +       
Sbjct: 465 IRRQELLNQKNREQEEIVRLNSKK-KNLHLELEALNGKHQQISGRLQDVRLKK------Q 517

Query: 236 SERKVIPIISKCLEGMILAAKSVDERRDSQMVVDSFKSGFEPPGDFPFEDYSQHIYRTIS 295
           +++  + ++ K  +  I+  K + +                       ++Y   +   + 
Sbjct: 518 TQKTELEVLDKQCDLEIMEIKQLQQE---------------------LQEYQNKLIYLVP 556

Query: 296 DGTISASKQESGKMDAKTTVGKAKGKLWLFGKKPKGPALEDFSHLPPEQRRKKLQQRIDE 355
           +               K  + +    +        G +L     L  E+  ++L++++D 
Sbjct: 557 E---------------KQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDA 601

Query: 356 LNRELQKESDQKDALN-KMKDVYEK-NPQMGDPGSLQPKLAETMNNIDRLRMEIHKNEAW 413
           L +E   +  + D+ N ++K++ E  N Q      L     + +  I+R R+E+ + +  
Sbjct: 602 LEKETASKLSEMDSFNNQLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKL 661

Query: 414 LSEV--EGKTGGRGDRRHSSDINHLVTQGRESPEGSYTDDANQEVRGPPQQHGHHNEFDD 471
             E   + K G     + +        Q R   E +      +E +   +Q    +    
Sbjct: 662 EDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKA 721

Query: 472 EFEDDDPLPAIGHCKAIYPFDGHNEGTLAMKEGEVLYIIEEDKGD-GWTRARRQNGEEGY 530
           E +  +    + + +A+YPF+  N   ++   G+++ + E+  G+ GW     Q G  G+
Sbjct: 722 EEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQ-GNFGW 780

Query: 531 VPTSYID 537
            P +Y++
Sbjct: 781 FPCNYVE 787



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 40/166 (24%), Positives = 75/166 (45%), Gaps = 20/166 (12%)

Query: 34  ERIEIEQNYAKQLRNLVKKYCPKRSSKDEEPRFTSCVAFFNILNELNDYAGQREVVAEEM 93
           E+ E+ Q   +QL  L K+   K S  D         +F N L EL +    +++  E++
Sbjct: 587 EKEELCQRLKEQLDALEKETASKLSEMD---------SFNNQLKELRETYNTQQLALEQL 637

Query: 94  ---AHRVYGELMRYAHDLKTERKMHLQEGRKAQQYLDMCWKQMDNSKKKFERECREAEKA 150
                    E+ R   +L  ++K+  +  RKA+Q  +  WK+   + +K E E ++  + 
Sbjct: 638 YKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKE---NLRKEEEEKQKRLQE 694

Query: 151 QQSYERLDNDTNATKADVEKAKQQLNLRTHMADENKNEYAAQLQNF 196
           +++ E++  +    +    K K  L      A+E K E A+ L N+
Sbjct: 695 EKTQEKIQEEERKAEEKQRKDKDTLK-----AEEKKRETASVLVNY 735



 Score = 35.4 bits (80), Expect = 0.14
 Identities = 15/57 (26%), Positives = 32/57 (56%), Gaps = 2/57 (3%)

Query: 487  AIYPFDGHNEGTLAMKEGEVLYIIEEDKGDGWTRARRQNGEEGYVPTSYIDVTLEKN 543
            A+Y +  +NE  L+  +G+++ ++ +D  D W      NG  G  P++Y+ +T + +
Sbjct: 1107 AMYDYAANNEDELSFSKGQLINVMNKDDPDWW--QGEINGVTGLFPSNYVKMTTDSD 1161



 Score = 30.8 bits (68), Expect = 3.3
 Identities = 15/50 (30%), Positives = 26/50 (52%), Gaps = 3/50 (6%)

Query: 487  AIYPFDGHNEGTLAMKEGEVLYIIEEDKGDGWTRARRQNGEEGYVPTSYI 536
            A+YP+     G L   EGE + + ++D G+ WT +       G  P++Y+
Sbjct: 961  ALYPYSSVEPGDLTFTEGEEILVTQKD-GEWWTGS--IGDRSGIFPSNYV 1007


>gi|11321634 CD2-associated protein [Homo sapiens]
          Length = 639

 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 20/63 (31%), Positives = 39/63 (61%), Gaps = 2/63 (3%)

Query: 474 EDDDPLPAIGHCKAIYPFDGHNEGTLAMKEGEVLYIIEEDKGD-GWTRARRQNGEEGYVP 532
           + +  + A  +C+ ++ ++G NE  L  KEGE++++I ++ G+ GW R    NG+EG  P
Sbjct: 263 DTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRG-ELNGKEGVFP 321

Query: 533 TSY 535
            ++
Sbjct: 322 DNF 324



 Score = 29.6 bits (65), Expect = 7.4
 Identities = 14/52 (26%), Positives = 28/52 (53%), Gaps = 2/52 (3%)

Query: 485 CKAIYPFDGHNEGTLAMKEGEVLYIIEEDKGDGWTRARRQNGEEGYVPTSYI 536
           CK ++ +   NE  L +K G+++ I EE +   W+     N + G  P++++
Sbjct: 113 CKVLFEYIPQNEDELELKVGDIIDINEEVEEGWWSGT--LNNKLGLFPSNFV 162


>gi|189491778 nephrocystin 1 isoform 4 [Homo sapiens]
          Length = 614

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 27/98 (27%), Positives = 44/98 (44%), Gaps = 1/98 (1%)

Query: 440 GRESPEGSYTDDANQEVRGPPQQHGHHNEFDDEFEDDDPLPAIGHCKAIYPFDGHNEGTL 499
           G  + E   ++  + E  G  ++     E + E  +           A+  F     G L
Sbjct: 50  GAPTEEEEESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDL 109

Query: 500 AMKEGEVLYIIEEDKGDGWTRARRQNGEEGYVPTSYID 537
             K+GE+L +IE+ K DGW  A+   G EG VP +Y++
Sbjct: 110 TFKKGEILLVIEK-KPDGWWIAKDAKGNEGLVPRTYLE 146


>gi|165905601 proline-serine-threonine phosphatase interacting
           protein 2 [Homo sapiens]
          Length = 334

 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 53/292 (18%), Positives = 116/292 (39%), Gaps = 41/292 (14%)

Query: 11  FDSLDKHTQWGIDFLERYAKFVKERIEIEQNYAKQLRNLVKKYCPKRSSKDEEPRFTSCV 70
           +D++ +H   G    + +  F+KER  IE+ Y K L NL +K   K   + E     +  
Sbjct: 21  YDNIIQHLNNGRKNCKEFEDFLKERAAIEERYGKDLLNLSRK---KPCGQSE---INTLK 74

Query: 71  AFFNILNELNDYAGQREVVAEEMAHRVYGELMRYAHDLKTERKMHLQEGRKAQQYLDMCW 130
               +  +  D   Q  +   +       ++  +    K +RK          +   + +
Sbjct: 75  RALEVFKQQVDNVAQCHIQLAQSLREEARKMEEFREKQKLQRKKTELIMDAIHKQKSLQF 134

Query: 131 KQMDNSKKKFERECREAEKAQQSYERLDNDTN------------ATKADVEKAKQQLNLR 178
           K+  ++KK +E++CR+ ++A+Q+  R  N  N             +K  VE + +   L 
Sbjct: 135 KKTMDAKKNYEQKCRDKDEAEQAVSRSANLVNPKQQEKLFVKLATSKTAVEDSDKAYMLH 194

Query: 179 THMADENKNEYAAQ----LQNFNGEQHKHFYVVIPQIYKQLQEMDERRTIKLSECYRGFA 234
               D+ + E+ ++     + F  ++ +        ++  + ++ + + +   E Y    
Sbjct: 195 IGTLDKVREEWQSEHIKACEAFEAQECERINFFRNALWLHVNQLSQ-QCVTSDEMY---- 249

Query: 235 DSERKVIPIISKCLEGMILAAKSVDERRDSQMVVDSFKSGFEPPGDFPFEDY 286
           +  RK + + S               +RD +  V+  K+G  PP    +E++
Sbjct: 250 EQVRKSLEMCS--------------IQRDIEYFVNQRKTGQIPPAPIMYENF 287


>gi|114155142 nuclear pore complex-associated protein TPR [Homo
            sapiens]
          Length = 2363

 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 79/367 (21%), Positives = 146/367 (39%), Gaps = 59/367 (16%)

Query: 75   ILNELNDYAGQREVVAEEMAHRVYGELMRYAHDLKTERKMHLQEGRKAQQYL-------- 126
            ++  L +   + + V EE+   +   L   A + +T+ +  L E  K +Q L        
Sbjct: 968  MVTSLEESLNKEKQVTEEVRKNIEVRLKESA-EFQTQLEKKLMEVEKEKQELQDDKRRAI 1026

Query: 127  DMCWKQMDNSKKKFERECREAEKA-QQSYERLDNDTNATKADVEKAKQQLNLRTHMADEN 185
            +   +Q+   KK       E ++A Q++   L N+  A +   E+AK        +A E 
Sbjct: 1027 ESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAK--------IAVEA 1078

Query: 186  KNEYAAQLQNFNGEQH-----KHFYVVIPQIYKQLQEMDERRTIKLSECYRGFADSERKV 240
            +N+Y  +L     +       K     +  + + L+E  ++   +L EC   + + ER +
Sbjct: 1079 QNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERML 1138

Query: 241  IPIISKCLEGMILAAKSVDERRDSQMVVDSFKSGFEPPGDFPFEDYSQHIYRTISDGT-- 298
               +SKC+       +  D  + ++++ D              E  S  +  ++ +G   
Sbjct: 1139 KDEVSKCV------CRCEDLEKQNRLLHDQ------------IEKLSDKVVASVKEGVQG 1180

Query: 299  -ISASKQESGKMDAKTTVGKAKGKLWLFGKKPKGPALEDFSHLPPEQRRKKLQQRIDELN 357
             ++ S  E GK   +        ++  F ++ K  A   F     E  R   +QR++ L 
Sbjct: 1181 PLNVSLSEEGKSQEQIL------EILRFIRREKEIAETRFEVAQVESLR--YRQRVELLE 1232

Query: 358  RELQKESDQKDALNKMKDVYEKNPQMGDPGSLQPKLAETMNNI----DRLRMEIHKNEAW 413
            RELQ+  D  +A  +   V  K   M     L  K  ETMN +      LR E  + E  
Sbjct: 1233 RELQELQDSLNAEREKVQVTAKT--MAQHEELMKK-TETMNVVMETNKMLREEKERLEQD 1289

Query: 414  LSEVEGK 420
            L +++ K
Sbjct: 1290 LQQMQAK 1296



 Score = 30.4 bits (67), Expect = 4.4
 Identities = 57/315 (18%), Positives = 121/315 (38%), Gaps = 33/315 (10%)

Query: 113 KMHLQEGRKAQQYLDMCWKQMDNSKKKFERECREAEKAQQSYERLDNDTNATKADVEKAK 172
           K   +E  +AQ+ +     +++ + K+ +R   + +KA +    L+ D    +  V+   
Sbjct: 438 KRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLS 497

Query: 173 QQLNLRTHMADENKNEYAAQLQNFNGEQHKHFYVVIPQ------IYKQLQEMDERRTIKL 226
           QQ+ +     +E +  +  + +  +         VI Q        ++LQ+ ++R  + L
Sbjct: 498 QQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVAL 557

Query: 227 SEC----YRGFADSERKVIPIISKCLEGMILAAKSVDERRDSQM-VVDSFKSGFEPPGDF 281
            E      R   ++    I  +   LE  +   + + + R  QM +VDS           
Sbjct: 558 RELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVR-------- 609

Query: 282 PFEDYSQHIYR-TISDGTISASKQESGKMD--AKTTVGKAKGKLWLFGKKPKGPALEDFS 338
                 + +YR  +S  T  A    +  +D  +  +  K              P +E   
Sbjct: 610 -----QRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTE 664

Query: 339 HLPPEQRRKKLQQRIDELNRE-LQKESDQKDALNKMK----DVYEKNPQMGDPGSLQPKL 393
            +  +   K+LQ+  +   +E  + E  Q + L K++    D+  +N ++        K 
Sbjct: 665 AIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKR 724

Query: 394 AETM-NNIDRLRMEI 407
            E + +N++  R EI
Sbjct: 725 YEMLQDNVEGYRREI 739


>gi|156071465 Rho GTPase activating protein 4 [Homo sapiens]
          Length = 946

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 66/327 (20%), Positives = 125/327 (38%), Gaps = 48/327 (14%)

Query: 1   MSWGTELWDQFDSLDKHTQWGIDFLERYAKFVKERIEIEQNYAKQLRNLVKKYCPK---- 56
           M W  +L +Q   L+   +   + L+  A+F++ R E+E  Y++ L  L +++  +    
Sbjct: 24  MRW--QLSEQLRCLELQGELRRELLQELAEFMRRRAEVELEYSRGLEKLAERFSSRGGRL 81

Query: 57  -----RSSKDEEPRFTSCVAFFNIL-----NELNDYAGQREVVAEEMAHRV------YGE 100
                  S  +EP   S +  + +L      +  + A   EV+A  +A R+       G 
Sbjct: 82  GSSREHQSFRKEPSLLSPLHCWAVLLQHTRQQSRESAALSEVLAGPLAQRLSHIAEDVGR 141

Query: 101 LMRYAHDLKTERKMHLQEGRKAQQYLDMCWKQMDNSKKKFERECREAEKAQQSYERLDND 160
           L++ + DL+ + +  L E     Q     ++         E + REAE+  Q  +R    
Sbjct: 142 LVKKSRDLEQQLQDELLEVVSELQTAKKTYQAYHMESVNAEAKLREAER--QEEKRAGRS 199

Query: 161 TNATKADVEKA----------------KQQLNLRTH--MADENKNEYAAQLQNFNGEQHK 202
              T A   +A                K+Q     H     + +NEY   L + N     
Sbjct: 200 VPTTTAGATEAGPLRKSSLKKGGRLVEKRQAKFMEHKLKCTKARNEYLLSLASVNAAVSN 259

Query: 203 HFYVVIPQIYKQLQEMDERRTIKLSECYRGFADSERKVIPIISKCLEGMILAAKSVDERR 262
           ++   +  +   +   D    + L +  R +  +E +      + L  +  A +++D   
Sbjct: 260 YY---LHDVLDLMDCCDTGFHLALGQVLRSYTAAESRTQASQVQGLGSLEEAVEALDPPG 316

Query: 263 DSQMVVDSFKSGFEPPGDFPFEDYSQH 289
           D   V++   + F PP  F   DY  H
Sbjct: 317 DKAKVLEVHATVFCPPLRF---DYHPH 340



 Score = 33.9 bits (76), Expect = 0.39
 Identities = 24/93 (25%), Positives = 35/93 (37%), Gaps = 5/93 (5%)

Query: 444 PEGSYTDDANQEVRGPPQQHGHHNEFDDEFEDDDPLPAIGHCKAIYPFDGHNEGTLAMKE 503
           P  S   DA  E  G   +     E   +   +D L  +    A + + G     L+ + 
Sbjct: 713 PSASCLGDAQLESLGADNEPELEAEMPAQ---EDDLEGVVEAVACFAYTGRTAQELSFRR 769

Query: 504 GEVLYIIEEDKGDGWTRARRQNGEEGYVPTSYI 536
           G+VL + E    D W      NG  G +P  YI
Sbjct: 770 GDVLRLHERASSDWW--RGEHNGMRGLIPHKYI 800


>gi|7706706 sorting nexin 9 [Homo sapiens]
          Length = 595

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 20/46 (43%), Positives = 27/46 (58%), Gaps = 2/46 (4%)

Query: 493 GHNEGTLAMKEGEVLYIIEEDKGDGWTRARRQNGEEGYVPTSYIDV 538
           G+NE  L + EGE++ I   D G GW   R   GE G VPT Y+++
Sbjct: 16  GNNE--LTVNEGEIITITNPDVGGGWLEGRNIKGERGLVPTDYVEI 59


>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
           sapiens]
          Length = 536

 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 17/50 (34%), Positives = 29/50 (58%)

Query: 487 AIYPFDGHNEGTLAMKEGEVLYIIEEDKGDGWTRARRQNGEEGYVPTSYI 536
           A+Y ++   E  L+ K+GE L I+   +GD W       G+ GY+P++Y+
Sbjct: 91  ALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYV 140


>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
           sapiens]
          Length = 536

 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 17/50 (34%), Positives = 29/50 (58%)

Query: 487 AIYPFDGHNEGTLAMKEGEVLYIIEEDKGDGWTRARRQNGEEGYVPTSYI 536
           A+Y ++   E  L+ K+GE L I+   +GD W       G+ GY+P++Y+
Sbjct: 91  ALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYV 140


>gi|55956916 myosin IE [Homo sapiens]
          Length = 1108

 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 19/59 (32%), Positives = 32/59 (54%), Gaps = 2/59 (3%)

Query: 478  PLPAIGHCKAIYPFDGHNEGTLAMKEGEVLYIIEEDKGDGWTRARRQNGEEGYVPTSYI 536
            P P +  CKA+Y +D  +   L+    +++ II+ED    WT   R  G++G  P +Y+
Sbjct: 1049 PKPQVPQCKALYAYDAQDTDELSFNANDIIDIIKEDPSGWWT--GRLRGKQGLFPNNYV 1105


>gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]
          Length = 659

 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 19/50 (38%), Positives = 33/50 (66%), Gaps = 1/50 (2%)

Query: 487 AIYPFDGHNEGTLAMKEGEVLYIIEEDKGDGWTRARRQNGEEGYVPTSYI 536
           A+Y +   N   L +++G+  +I+EE     W RAR +NG+EGY+P++Y+
Sbjct: 221 ALYDYMPMNANDLQLRKGDEYFILEESNLPWW-RARDKNGQEGYIPSNYV 269


>gi|5453754 NCK adaptor protein 1 [Homo sapiens]
          Length = 377

 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 20/54 (37%), Positives = 34/54 (62%), Gaps = 1/54 (1%)

Query: 486 KAIYPFDGHNEGTLAMKEGEVLYIIEEDKGD-GWTRARRQNGEEGYVPTSYIDV 538
           +A+YPF   N+  L  ++G+V+ +IE+ + D  W + R+ NG  G VP +Y+ V
Sbjct: 196 QALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVGLVPKNYVTV 249



 Score = 33.1 bits (74), Expect = 0.67
 Identities = 17/58 (29%), Positives = 32/58 (55%), Gaps = 5/58 (8%)

Query: 487 AIYPFDGHNEGTLAMKEGEVLYIIEEDKGDGWTRARRQNGEEGYVPTSYIDVTLEKNS 544
           A + +    E  L +K+ E L+++++ K   W R R    + G+VP++Y++    KNS
Sbjct: 9   AKFDYVAQQEQELDIKKNERLWLLDDSKS--WWRVRNSMNKTGFVPSNYVE---RKNS 61


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.132    0.387 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,313,012
Number of Sequences: 37866
Number of extensions: 1063028
Number of successful extensions: 4833
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 114
Number of HSP's successfully gapped in prelim test: 286
Number of HSP's that attempted gapping in prelim test: 4118
Number of HSP's gapped (non-prelim): 963
length of query: 547
length of database: 18,247,518
effective HSP length: 107
effective length of query: 440
effective length of database: 14,195,856
effective search space: 6246176640
effective search space used: 6246176640
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.