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Search of human proteins with 41350337
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|41350337 toll-like receptor 1 [Homo sapiens]
(786 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|41350337 toll-like receptor 1 [Homo sapiens] 1578 0.0
gi|20143971 toll-like receptor 6 [Homo sapiens] 1093 0.0
gi|62865621 toll-like receptor 10 precursor [Homo sapiens] 742 0.0
gi|62865618 toll-like receptor 10 precursor [Homo sapiens] 742 0.0
gi|19718734 toll-like receptor 2 [Homo sapiens] 350 4e-96
gi|20302168 toll-like receptor 8 [Homo sapiens] 160 4e-39
gi|19924149 toll-like receptor 4 precursor [Homo sapiens] 146 6e-35
gi|7706093 toll-like receptor 7 [Homo sapiens] 131 3e-30
gi|16751843 toll-like receptor 5 [Homo sapiens] 125 2e-28
gi|4507531 toll-like receptor 3 [Homo sapiens] 118 2e-26
gi|8394456 toll-like receptor 9 isoform A precursor [Homo sapiens] 102 1e-21
gi|4504379 leucine-rich repeat-containing G protein-coupled rece... 69 2e-11
gi|4504655 interleukin 18 receptor 1 precursor [Homo sapiens] 68 4e-11
gi|197333706 leucine rich repeat containing 8 family, member D [... 65 2e-10
gi|34222199 leucine rich repeat containing 8 family, member D [H... 65 2e-10
gi|4504661 interleukin 1 receptor accessory protein isoform 1 [H... 63 1e-09
gi|21361633 leucine rich repeat containing 40 [Homo sapiens] 62 2e-09
gi|238908508 leucine-rich repeat and death domain-containing pro... 60 8e-09
gi|88702793 slit-like 2 [Homo sapiens] 60 1e-08
gi|19743846 decorin isoform a preproprotein [Homo sapiens] 57 5e-08
gi|4503271 decorin isoform a preproprotein [Homo sapiens] 57 5e-08
gi|7657232 interleukin 1 receptor accessory protein-like 1 precu... 57 5e-08
gi|62912470 leucine-rich repeat-containing G protein-coupled rec... 56 1e-07
gi|11321571 slit homolog 3 [Homo sapiens] 55 2e-07
gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens] 55 2e-07
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens] 55 3e-07
gi|19923729 leucine rich repeat containing 8 family, member C [H... 54 4e-07
gi|110825984 malignant fibrous histiocytoma amplified sequence 1... 54 4e-07
gi|188528675 slit homolog 1 [Homo sapiens] 54 4e-07
gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens] 54 6e-07
>gi|41350337 toll-like receptor 1 [Homo sapiens]
Length = 786
Score = 1578 bits (4085), Expect = 0.0
Identities = 786/786 (100%), Positives = 786/786 (100%)
Query: 1 MTSIFHFAIIFMLILQIRIQLSEESEFLVDRSKNGLIHVPKDLSQKTTILNISQNYISEL 60
MTSIFHFAIIFMLILQIRIQLSEESEFLVDRSKNGLIHVPKDLSQKTTILNISQNYISEL
Sbjct: 1 MTSIFHFAIIFMLILQIRIQLSEESEFLVDRSKNGLIHVPKDLSQKTTILNISQNYISEL 60
Query: 61 WTSDILSLSKLRILIISHNRIQYLDISVFKFNQELEYLDLSHNKLVKISCHPTVNLKHLD 120
WTSDILSLSKLRILIISHNRIQYLDISVFKFNQELEYLDLSHNKLVKISCHPTVNLKHLD
Sbjct: 61 WTSDILSLSKLRILIISHNRIQYLDISVFKFNQELEYLDLSHNKLVKISCHPTVNLKHLD 120
Query: 121 LSFNAFDALPICKEFGNMSQLKFLGLSTTHLEKSSVLPIAHLNISKVLLVLGETYGEKED 180
LSFNAFDALPICKEFGNMSQLKFLGLSTTHLEKSSVLPIAHLNISKVLLVLGETYGEKED
Sbjct: 121 LSFNAFDALPICKEFGNMSQLKFLGLSTTHLEKSSVLPIAHLNISKVLLVLGETYGEKED 180
Query: 181 PEGLQDFNTESLHIVFPTNKEFHFILDVSVKTVANLELSNIKCVLEDNKCSYFLSILAKL 240
PEGLQDFNTESLHIVFPTNKEFHFILDVSVKTVANLELSNIKCVLEDNKCSYFLSILAKL
Sbjct: 181 PEGLQDFNTESLHIVFPTNKEFHFILDVSVKTVANLELSNIKCVLEDNKCSYFLSILAKL 240
Query: 241 QTNPKLSNLTLNNIETTWNSFIRILQLVWHTTVWYFSISNVKLQGQLDFRDFDYSGTSLK 300
QTNPKLSNLTLNNIETTWNSFIRILQLVWHTTVWYFSISNVKLQGQLDFRDFDYSGTSLK
Sbjct: 241 QTNPKLSNLTLNNIETTWNSFIRILQLVWHTTVWYFSISNVKLQGQLDFRDFDYSGTSLK 300
Query: 301 ALSIHQVVSDVFGFPQSYIYEIFSNMNIKNFTVSGTRMVHMLCPSKISPFLHLDFSNNLL 360
ALSIHQVVSDVFGFPQSYIYEIFSNMNIKNFTVSGTRMVHMLCPSKISPFLHLDFSNNLL
Sbjct: 301 ALSIHQVVSDVFGFPQSYIYEIFSNMNIKNFTVSGTRMVHMLCPSKISPFLHLDFSNNLL 360
Query: 361 TDTVFENCGHLTELETLILQMNQLKELSKIAEMTTQMKSLQQLDISQNSVSYDEKKGDCS 420
TDTVFENCGHLTELETLILQMNQLKELSKIAEMTTQMKSLQQLDISQNSVSYDEKKGDCS
Sbjct: 361 TDTVFENCGHLTELETLILQMNQLKELSKIAEMTTQMKSLQQLDISQNSVSYDEKKGDCS 420
Query: 421 WTKSLLSLNMSSNILTDTIFRCLPPRIKVLDLHSNKIKSIPKQVVKLEALQELNVAFNSL 480
WTKSLLSLNMSSNILTDTIFRCLPPRIKVLDLHSNKIKSIPKQVVKLEALQELNVAFNSL
Sbjct: 421 WTKSLLSLNMSSNILTDTIFRCLPPRIKVLDLHSNKIKSIPKQVVKLEALQELNVAFNSL 480
Query: 481 TDLPGCGSFSSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQCTCELGEFVKNID 540
TDLPGCGSFSSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQCTCELGEFVKNID
Sbjct: 481 TDLPGCGSFSSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQCTCELGEFVKNID 540
Query: 541 QVSSEVLEGWPDSYKCDYPESYRGTLLKDFHMSELSCNITLLIVTIVATMLVLAVTVTSL 600
QVSSEVLEGWPDSYKCDYPESYRGTLLKDFHMSELSCNITLLIVTIVATMLVLAVTVTSL
Sbjct: 541 QVSSEVLEGWPDSYKCDYPESYRGTLLKDFHMSELSCNITLLIVTIVATMLVLAVTVTSL 600
Query: 601 CSYLDLPWYLRMVCQWTQTRRRARNIPLEELQRNLQFHAFISYSGHDSFWVKNELLPNLE 660
CSYLDLPWYLRMVCQWTQTRRRARNIPLEELQRNLQFHAFISYSGHDSFWVKNELLPNLE
Sbjct: 601 CSYLDLPWYLRMVCQWTQTRRRARNIPLEELQRNLQFHAFISYSGHDSFWVKNELLPNLE 660
Query: 661 KEGMQICLHERNFVPGKSIVENIITCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFH 720
KEGMQICLHERNFVPGKSIVENIITCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFH
Sbjct: 661 KEGMQICLHERNFVPGKSIVENIITCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFH 720
Query: 721 EGSNSLILILLEPIPQYSIPSSYHKLKSLMARRTYLEWPKEKSKRGLFWANLRAAINIKL 780
EGSNSLILILLEPIPQYSIPSSYHKLKSLMARRTYLEWPKEKSKRGLFWANLRAAINIKL
Sbjct: 721 EGSNSLILILLEPIPQYSIPSSYHKLKSLMARRTYLEWPKEKSKRGLFWANLRAAINIKL 780
Query: 781 TEQAKK 786
TEQAKK
Sbjct: 781 TEQAKK 786
>gi|20143971 toll-like receptor 6 [Homo sapiens]
Length = 796
Score = 1093 bits (2827), Expect = 0.0
Identities = 540/777 (69%), Positives = 631/777 (81%), Gaps = 2/777 (0%)
Query: 5 FHFAIIFMLILQIRIQLSEESEFLVDRSKNGLIHVPKDLSQKTTILNISQNYISELWTSD 64
FHF + ++I+ RIQ S+ +EF VD+SK GLIHVPKDL KT +L++SQNYI+EL SD
Sbjct: 12 FHFVCLMIIIVGTRIQFSDGNEFAVDKSKRGLIHVPKDLPLKTKVLDMSQNYIAELQVSD 71
Query: 65 ILSLSKLRILIISHNRIQYLDISVFKFNQELEYLDLSHNKLVKISCHPTVNLKHLDLSFN 124
+ LS+L +L +SHNRIQ LD+SVFKFNQ+LEYLDLSHN+L KISCHP V+ +HLDLSFN
Sbjct: 72 MSFLSELTVLRLSHNRIQLLDLSVFKFNQDLEYLDLSHNQLQKISCHPIVSFRHLDLSFN 131
Query: 125 AFDALPICKEFGNMSQLKFLGLSTTHLEKSSVLPIAHLNISKVLLVLGETYGEKEDPEGL 184
F ALPICKEFGN+SQL FLGLS L+K +LPIAHL++S +LL L Y ++ + E L
Sbjct: 132 DFKALPICKEFGNLSQLNFLGLSAMKLQKLDLLPIAHLHLSYILLDLRNYYIKENETESL 191
Query: 185 QDFNTESLHIVFPTNKEFHFILDVSVKTVANLELSNIKCVLEDNKCSYFLSILAKLQTNP 244
Q N ++LH+VF F +++SV T+ L+L+NIK L D+ C F+ L++L
Sbjct: 192 QILNAKTLHLVFHPTSLFAIQVNISVNTLGCLQLTNIK--LNDDNCQVFIKFLSELTRGS 249
Query: 245 KLSNLTLNNIETTWNSFIRILQLVWHTTVWYFSISNVKLQGQLDFRDFDYSGTSLKALSI 304
L N TLN+IETTW +R+ Q +W V Y +I N+ + + DF YS T+LKAL+I
Sbjct: 250 TLLNFTLNHIETTWKCLVRVFQFLWPKPVEYLNIYNLTIIESIREEDFTYSKTTLKALTI 309
Query: 305 HQVVSDVFGFPQSYIYEIFSNMNIKNFTVSGTRMVHMLCPSKISPFLHLDFSNNLLTDTV 364
+ + VF F Q+ +Y +FS MNI T+S T +HMLCP S F L+F+ N+ TD++
Sbjct: 310 EHITNQVFLFSQTALYTVFSEMNIMMLTISDTPFIHMLCPHAPSTFKFLNFTQNVFTDSI 369
Query: 365 FENCGHLTELETLILQMNQLKELSKIAEMTTQMKSLQQLDISQNSVSYDEKKGDCSWTKS 424
FE C L +LETLILQ N LK+L K+ MT M SL+ LD+S NS+ K +C+W +S
Sbjct: 370 FEKCSTLVKLETLILQKNGLKDLFKVGLMTKDMPSLEILDVSWNSLESGRHKENCTWVES 429
Query: 425 LLSLNMSSNILTDTIFRCLPPRIKVLDLHSNKIKSIPKQVVKLEALQELNVAFNSLTDLP 484
++ LN+SSN+LTD++FRCLPPRIKVLDLHSNKIKS+PKQVVKLEALQELNVAFNSLTDLP
Sbjct: 430 IVVLNLSSNMLTDSVFRCLPPRIKVLDLHSNKIKSVPKQVVKLEALQELNVAFNSLTDLP 489
Query: 485 GCGSFSSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQCTCELGEFVKNIDQVSS 544
GCGSFSSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQCTCEL EFVKNIDQVSS
Sbjct: 490 GCGSFSSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQCTCELREFVKNIDQVSS 549
Query: 545 EVLEGWPDSYKCDYPESYRGTLLKDFHMSELSCNITLLIVTIVATMLVLAVTVTSLCSYL 604
EVLEGWPDSYKCDYPESYRG+ LKDFHMSELSCNITLLIVTI ATMLVLAVTVTSLC YL
Sbjct: 550 EVLEGWPDSYKCDYPESYRGSPLKDFHMSELSCNITLLIVTIGATMLVLAVTVTSLCIYL 609
Query: 605 DLPWYLRMVCQWTQTRRRARNIPLEELQRNLQFHAFISYSGHDSFWVKNELLPNLEKEGM 664
DLPWYLRMVCQWTQTRRRARNIPLEELQRNLQFHAFISYS HDS WVK+EL+P LEKE +
Sbjct: 610 DLPWYLRMVCQWTQTRRRARNIPLEELQRNLQFHAFISYSEHDSAWVKSELVPYLEKEDI 669
Query: 665 QICLHERNFVPGKSIVENIITCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFHEGSN 724
QICLHERNFVPGKSIVENII CIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFHEGSN
Sbjct: 670 QICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFHEGSN 729
Query: 725 SLILILLEPIPQYSIPSSYHKLKSLMARRTYLEWPKEKSKRGLFWANLRAAINIKLT 781
+LILILLEPIPQ SIP+ YHKLK+LM +RTYL+WPKEKSKRGLFWAN+RAA N+KLT
Sbjct: 730 NLILILLEPIPQNSIPNKYHKLKALMTQRTYLQWPKEKSKRGLFWANIRAAFNMKLT 786
>gi|62865621 toll-like receptor 10 precursor [Homo sapiens]
Length = 811
Score = 742 bits (1915), Expect = 0.0
Identities = 389/782 (49%), Positives = 528/782 (67%), Gaps = 12/782 (1%)
Query: 3 SIFHFAIIFMLILQIRIQLSEESEFLVDRSKNGLIHVPKDLSQKTTILNISQNYISELWT 62
+I+ F I M +L EE E + + S L VP DL+ TT L++S N + +L +
Sbjct: 6 NIYIFCSIVMTAEGDAPELPEERELMTNCSNMSLRKVPADLTPATTTLDLSYNLLFQLQS 65
Query: 63 SDILSLSKLRILIISHNRIQYLDISVFKFNQELEYLDLSHNKLVKISCHPTVNLKHLDLS 122
SD S+SKLR+LI+ HNRIQ LD+ F+FN+EL YLDLS+N+L ++ + L++LDLS
Sbjct: 66 SDFHSVSKLRVLILCHNRIQQLDLKTFEFNKELRYLDLSNNRLKSVTWYLLAGLRYLDLS 125
Query: 123 FNAFDALPICKEFGNMSQLKFLGLSTTHLEKSSVLPIAHLNISKVLLVLGETYGEKEDPE 182
FN FD +PIC+E GNMS L+ LGLS ++KS IAHL+++ V L +E
Sbjct: 126 FNDFDTMPICEEAGNMSHLEILGLSGAKIQKSDFQKIAHLHLNTVFLGFRTLPHYEEG-- 183
Query: 183 GLQDFNTESLHIVFPTNKEFHFILDVSVKTVANLELSNIKCVLEDNKCSYFLSILAKLQT 242
L NT LHIV P + F +L +KT LE++NI + SY + L+
Sbjct: 184 SLPILNTTKLHIVLPMDTNFWVLLRDGIKTSKILEMTNIDG--KSQFVSYEMQRNLSLE- 240
Query: 243 NPKLSNLTLNNIETTWNSFIRILQLVWHTTVWYFSISNVKLQGQ--LDFRDFDYSGTSLK 300
N K S L LN ++ W+ ILQ VWHT+V +F I NV G+ LD FDYS T ++
Sbjct: 241 NAKTSVLLLNKVDLLWDDLFLILQFVWHTSVEHFQIRNVTFGGKAYLDHNSFDYSNTVMR 300
Query: 301 ALSIHQVVSDVFGFPQSYIYEIFSNMNIKNFTVSGTRMVHMLCPSKISPFLHLDFSNNLL 360
+ + V VF Q IY + + M+I+N T+S +M HML P+ + F +L+F+NN+L
Sbjct: 301 TIKLEHVHFRVFYIQQDKIYLLLTKMDIENLTISNAQMPHMLFPNYPTKFQYLNFANNIL 360
Query: 361 TDTVFENCGHLTELETLILQMNQLKELSKIAEMTTQMKSLQQLDISQNSVSYDEKKGDCS 420
TD +F+ L L+TLIL N+L+ LS ++ L+ LD+SQN + + + +CS
Sbjct: 361 TDELFKRTIQLPHLKTLILNGNKLETLSLVSCFANNTP-LEHLDLSQNLLQHKNDE-NCS 418
Query: 421 WTKSLLSLNMSSNILTDTIFRCLPPRIKVLDLHSNKIKSIPKQVVKLEALQELNVAFNSL 480
W ++++++N+S N L+D++FRCLP I++LDL++N+I+++PK+ + L AL+ELN+AFN L
Sbjct: 419 WPETVVNMNLSYNKLSDSVFRCLPKSIQILDLNNNQIQTVPKETIHLMALRELNIAFNFL 478
Query: 481 TDLPGCGSFSSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQCTCELGEFVKNID 540
TDLPGC FS LSVL I+ N + PS DF QSCQ+++++ AG NPF+CTCEL F++ ++
Sbjct: 479 TDLPGCSHFSRLSVLNIEMNFILSPSLDFVQSCQEVKTLNAGRNPFRCTCELKNFIQ-LE 537
Query: 541 QVSSEVLEGWPDSYKCDYPESYRGTLLKDFHMSELSCNITLLIVTIVATMLVLAVTVTSL 600
S ++ GW DSY C+YP + RGT LKD H+ ELSCN LLIVTIV MLVL + V
Sbjct: 538 TYSEVMMVGWSDSYTCEYPLNLRGTRLKDVHLHELSCNTALLIVTIVVIMLVLGLAVAFC 597
Query: 601 CSYLDLPWYLRMVCQWTQTRRRARNIPLEELQRNLQFHAFISYSGHDSFWVKNELLPNLE 660
C + DLPWYLRM+ Q TQT R R E+L+RN++FHAFISYS HDS WVKNEL+PNLE
Sbjct: 598 CLHFDLPWYLRMLGQCTQTWHRVRKTTQEQLKRNVRFHAFISYSEHDSLWVKNELIPNLE 657
Query: 661 KE--GMQICLHERNFVPGKSIVENIITCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNL 718
KE + ICL+E F PGKSI ENI++ IEKSYKSIFVLSPNFVQ+EWCHYE YFAHHNL
Sbjct: 658 KEDGSILICLYESYFDPGKSISENIVSFIEKSYKSIFVLSPNFVQNEWCHYEFYFAHHNL 717
Query: 719 FHEGSNSLILILLEPIPQYSIPSSYHKLKSLMARRTYLEWPKEKSKRGLFWANLRAAINI 778
FHE S+ +ILILLEPIP Y IP+ YHKLK+L+ ++ YLEWPK++ K GLFWANLRAAIN+
Sbjct: 718 FHENSDHIILILLEPIPFYCIPTRYHKLKALLEKKAYLEWPKDRRKCGLFWANLRAAINV 777
Query: 779 KL 780
+
Sbjct: 778 NV 779
>gi|62865618 toll-like receptor 10 precursor [Homo sapiens]
Length = 811
Score = 742 bits (1915), Expect = 0.0
Identities = 389/782 (49%), Positives = 528/782 (67%), Gaps = 12/782 (1%)
Query: 3 SIFHFAIIFMLILQIRIQLSEESEFLVDRSKNGLIHVPKDLSQKTTILNISQNYISELWT 62
+I+ F I M +L EE E + + S L VP DL+ TT L++S N + +L +
Sbjct: 6 NIYIFCSIVMTAEGDAPELPEERELMTNCSNMSLRKVPADLTPATTTLDLSYNLLFQLQS 65
Query: 63 SDILSLSKLRILIISHNRIQYLDISVFKFNQELEYLDLSHNKLVKISCHPTVNLKHLDLS 122
SD S+SKLR+LI+ HNRIQ LD+ F+FN+EL YLDLS+N+L ++ + L++LDLS
Sbjct: 66 SDFHSVSKLRVLILCHNRIQQLDLKTFEFNKELRYLDLSNNRLKSVTWYLLAGLRYLDLS 125
Query: 123 FNAFDALPICKEFGNMSQLKFLGLSTTHLEKSSVLPIAHLNISKVLLVLGETYGEKEDPE 182
FN FD +PIC+E GNMS L+ LGLS ++KS IAHL+++ V L +E
Sbjct: 126 FNDFDTMPICEEAGNMSHLEILGLSGAKIQKSDFQKIAHLHLNTVFLGFRTLPHYEEG-- 183
Query: 183 GLQDFNTESLHIVFPTNKEFHFILDVSVKTVANLELSNIKCVLEDNKCSYFLSILAKLQT 242
L NT LHIV P + F +L +KT LE++NI + SY + L+
Sbjct: 184 SLPILNTTKLHIVLPMDTNFWVLLRDGIKTSKILEMTNIDG--KSQFVSYEMQRNLSLE- 240
Query: 243 NPKLSNLTLNNIETTWNSFIRILQLVWHTTVWYFSISNVKLQGQ--LDFRDFDYSGTSLK 300
N K S L LN ++ W+ ILQ VWHT+V +F I NV G+ LD FDYS T ++
Sbjct: 241 NAKTSVLLLNKVDLLWDDLFLILQFVWHTSVEHFQIRNVTFGGKAYLDHNSFDYSNTVMR 300
Query: 301 ALSIHQVVSDVFGFPQSYIYEIFSNMNIKNFTVSGTRMVHMLCPSKISPFLHLDFSNNLL 360
+ + V VF Q IY + + M+I+N T+S +M HML P+ + F +L+F+NN+L
Sbjct: 301 TIKLEHVHFRVFYIQQDKIYLLLTKMDIENLTISNAQMPHMLFPNYPTKFQYLNFANNIL 360
Query: 361 TDTVFENCGHLTELETLILQMNQLKELSKIAEMTTQMKSLQQLDISQNSVSYDEKKGDCS 420
TD +F+ L L+TLIL N+L+ LS ++ L+ LD+SQN + + + +CS
Sbjct: 361 TDELFKRTIQLPHLKTLILNGNKLETLSLVSCFANNTP-LEHLDLSQNLLQHKNDE-NCS 418
Query: 421 WTKSLLSLNMSSNILTDTIFRCLPPRIKVLDLHSNKIKSIPKQVVKLEALQELNVAFNSL 480
W ++++++N+S N L+D++FRCLP I++LDL++N+I+++PK+ + L AL+ELN+AFN L
Sbjct: 419 WPETVVNMNLSYNKLSDSVFRCLPKSIQILDLNNNQIQTVPKETIHLMALRELNIAFNFL 478
Query: 481 TDLPGCGSFSSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQCTCELGEFVKNID 540
TDLPGC FS LSVL I+ N + PS DF QSCQ+++++ AG NPF+CTCEL F++ ++
Sbjct: 479 TDLPGCSHFSRLSVLNIEMNFILSPSLDFVQSCQEVKTLNAGRNPFRCTCELKNFIQ-LE 537
Query: 541 QVSSEVLEGWPDSYKCDYPESYRGTLLKDFHMSELSCNITLLIVTIVATMLVLAVTVTSL 600
S ++ GW DSY C+YP + RGT LKD H+ ELSCN LLIVTIV MLVL + V
Sbjct: 538 TYSEVMMVGWSDSYTCEYPLNLRGTRLKDVHLHELSCNTALLIVTIVVIMLVLGLAVAFC 597
Query: 601 CSYLDLPWYLRMVCQWTQTRRRARNIPLEELQRNLQFHAFISYSGHDSFWVKNELLPNLE 660
C + DLPWYLRM+ Q TQT R R E+L+RN++FHAFISYS HDS WVKNEL+PNLE
Sbjct: 598 CLHFDLPWYLRMLGQCTQTWHRVRKTTQEQLKRNVRFHAFISYSEHDSLWVKNELIPNLE 657
Query: 661 KE--GMQICLHERNFVPGKSIVENIITCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNL 718
KE + ICL+E F PGKSI ENI++ IEKSYKSIFVLSPNFVQ+EWCHYE YFAHHNL
Sbjct: 658 KEDGSILICLYESYFDPGKSISENIVSFIEKSYKSIFVLSPNFVQNEWCHYEFYFAHHNL 717
Query: 719 FHEGSNSLILILLEPIPQYSIPSSYHKLKSLMARRTYLEWPKEKSKRGLFWANLRAAINI 778
FHE S+ +ILILLEPIP Y IP+ YHKLK+L+ ++ YLEWPK++ K GLFWANLRAAIN+
Sbjct: 718 FHENSDHIILILLEPIPFYCIPTRYHKLKALLEKKAYLEWPKDRRKCGLFWANLRAAINV 777
Query: 779 KL 780
+
Sbjct: 778 NV 779
>gi|19718734 toll-like receptor 2 [Homo sapiens]
Length = 784
Score = 350 bits (897), Expect = 4e-96
Identities = 229/769 (29%), Positives = 399/769 (51%), Gaps = 49/769 (6%)
Query: 32 SKNGLIHVPKDLSQKTTILNISQNYISELWTSDILSLSKLRILIISHNRIQYLDISVFKF 91
S L +P L++ L++S N I+ + SD+ L+ L+++ N I ++ F
Sbjct: 39 SSGSLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSS 98
Query: 92 NQELEYLDLSHNKLVKISCH---PTVNLKHLDLSFNAFDALPICKEFGNMSQLKFLGLST 148
LE+LDLS+N L +S P +L L+L N + L F ++++L+ L +
Sbjct: 99 LGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGN 158
Query: 149 ----THLEKSSVLPIAHLNISKVLLVLGETYGEKEDPEGLQDFNTESLHIVFPTNKEFHF 204
T +++ + L ++ ++Y E + + +Q+ + LH+ K+
Sbjct: 159 MDTFTKIQRKDFAGLTFLEELEIDASDLQSY-EPKSLKSIQNVSHLILHM-----KQHIL 212
Query: 205 ILDVSVKTVANLELSNIKCVLEDNKCSYFLSILAKLQTNPKLSNLTLNNIETTWNSFIRI 264
+L++ V +++E ++ + + ++ S L+ +TN + T N++ T S ++
Sbjct: 213 LLEIFVDVTSSVECLELR---DTDLDTFHFSELSTGETNSLIKKFTFRNVKITDESLFQV 269
Query: 265 LQLVWHTT-VWYFSISNVKLQGQLDFRDFDYSGT----SLKALSIHQVVSDVFGFPQSYI 319
++L+ + + + L G +FR D ++ L+I ++ P+ Y+
Sbjct: 270 MKLLNQISGLLELEFDDCTLNGVGNFRASDNDRVIDPGKVETLTIRRL-----HIPRFYL 324
Query: 320 YEIFSNM-----NIKNFTVSGTR--MVHMLCPSKISPFLHLDFSNNLLTDTVFENCG--- 369
+ S + +K TV ++ +V L + +LD S NL+ + +N
Sbjct: 325 FYDLSTLYSLTERVKRITVENSKVFLVPCLLSQHLKSLEYLDLSENLMVEEYLKNSACED 384
Query: 370 HLTELETLILQMNQLKELSKIAEMTTQMKSLQQLDISQNSVSYDEKKGDCSWTKSLLSLN 429
L+TLIL+ N L L K E +K+L +DIS+NS + C W + + LN
Sbjct: 385 AWPSLQTLILRQNHLASLEKTGETLLTLKNLTNIDISKNS--FHSMPETCQWPEKMKYLN 442
Query: 430 MSSNILTDTIFRCLPPRIKVLDLHSNKIKSIPKQVVKLEALQELNVAFNSLTDLPGCGSF 489
+SS + ++ C+P +++LD+ +N + + L L+EL ++ N L LP
Sbjct: 443 LSSTRI-HSVTGCIPKTLEILDVSNNNLNLFS---LNLPQLKELYISRNKLMTLPDASLL 498
Query: 490 SSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQCTCELGEFVKNIDQVSSEVLEG 549
L VL I N+++ S + S +++++AG N F C+CE F + Q ++VL
Sbjct: 499 PMLLVLKISRNAITTFSKEQLDSFHTLKTLEAGGNNFICSCEFLSFTQE-QQALAKVLID 557
Query: 550 WPDSYKCDYPESYRGTLLKDFHMSELSCNITLLIVTIVATMLVLAVTVTSLCSYLDLPWY 609
WP +Y CD P RG ++D +S C+ T L+ + + +L + LC WY
Sbjct: 558 WPANYLCDSPSHVRGQQVQDVRLSVSECHRTALVSGMCCALFLLILLTGVLCHRFHGLWY 617
Query: 610 LRMVCQWTQTRRRARNIPLEELQRNLQFHAFISYSGHDSFWVKNELLPNLEKEG--MQIC 667
++M+ W Q +R+ R P RN+ + AF+SYS D++WV+N ++ LE ++C
Sbjct: 618 MKMMWAWLQAKRKPRKAP----SRNICYDAFVSYSERDAYWVENLMVQELENFNPPFKLC 673
Query: 668 LHERNFVPGKSIVENIITCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFHEGSNSLI 727
LH+R+F+PGK I++NII IEKS+K++FVLS NFV+SEWC YEL F+H LF E +++ I
Sbjct: 674 LHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFSHFRLFDENNDAAI 733
Query: 728 LILLEPIPQYSIPSSYHKLKSLMARRTYLEWPKEKSKRGLFWANLRAAI 776
LILLEPI + +IP + KL+ +M +TYLEWP ++++R FW NLRAAI
Sbjct: 734 LILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVNLRAAI 782
>gi|20302168 toll-like receptor 8 [Homo sapiens]
Length = 1041
Score = 160 bits (405), Expect = 4e-39
Identities = 218/867 (25%), Positives = 360/867 (41%), Gaps = 158/867 (18%)
Query: 28 LVDRSKNGLIHVPKDLSQKTTILNISQNYISELWTSDILSLSKLRILIISHNRIQY---- 83
L+ S N L HVP L L +S I + D L L +L +S N +
Sbjct: 205 LLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAP 264
Query: 84 -----------LDISVFKFNQ--ELEYLDLSHNKLVKISCHPTVNLKHL---DLSFNAFD 127
++I F F +L YL+LS L KI+ N+ HL DL FN
Sbjct: 265 FPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLV 324
Query: 128 ALPICKEFGNM-SQLKFLGLSTTHLEKSSVLPIAHLNISK---------VLLVLGETYGE 177
F M +L+ L LS +++ S H+NIS+ L + G + E
Sbjct: 325 GEIASGAFLTMLPRLEILDLSFNYIKGSYP---QHINISRNFSKLLSLRALHLRGYVFQE 381
Query: 178 KEDPEGLQDFNTESLHIVFPTNKEFHFILDVSVKTVANLELSNIKCV-LEDNKCSYFLSI 236
+ + +L + N +FI + K N SN++ + L +N+ S +
Sbjct: 382 LREDDFQPLMQLPNLSTI---NLGINFIKQIDFKLFQNF--SNLEIIYLSENRISPLVKD 436
Query: 237 LAKLQTNPKLSNLTLNNIETTWNSFIRILQLVWHTTVWYFSISNVKLQGQLDFRDFDYSG 296
+ N + +T F H+ ++F+ +K Q + D S
Sbjct: 437 TRQSYANSSSFQRHIRKRRSTDFEFDP------HSNFYHFTRPLIKPQCAAYGKALDLSL 490
Query: 297 TSLKALSIHQVVSDVFGFPQSYIYEIFSNMNIKNFTVSGTRMVHMLCPSKISPFLHLDFS 356
S+ + +Q + P + +N N + +SGT S I +LD +
Sbjct: 491 NSIFFIGPNQFEN----LPDIACLNLSANSNAQ--VLSGTEF------SAIPHVKYLDLT 538
Query: 357 NNLLTDTVFENCGHLTELETL-ILQMNQLKELSKIAEMTTQMKSLQQ------LDISQNS 409
NN L F+N LTEL L +L ++ +IA +T ++ +Q L++S N+
Sbjct: 539 NNRLD---FDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNN 595
Query: 410 VSYDEKKGDCSWTKSLLSLNMSSNILTD----------TIFRCLPPRIKVLDLHSNKIKS 459
+ K + +KSL+ L S N L +IF+ L + LDL N++K
Sbjct: 596 IYTLTDKYNLE-SKSLVELVFSGNRLDILWNDDDNRYISIFKGLK-NLTRLDLSLNRLKH 653
Query: 460 IPKQV-VKLEA-LQELNVAFN----------------SLTDLPG----------CGSFSS 491
IP + + L A L EL++ N L DL G SS
Sbjct: 654 IPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSS 713
Query: 492 LSVLIIDHNSVSHPSADFF--------------------------QSCQKMRSIKAGDNP 525
L L++ HN +SH + F ++ K+ ++ NP
Sbjct: 714 LRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNP 773
Query: 526 FQCTCELGEFVKNIDQVSSEVLEGWPDSYKCDYPESYRGTLLKDFHMSELSCNITLLIV- 584
F+CTC++G+F + +D+ + + D C P RG + ++ ++T +I+
Sbjct: 774 FECTCDIGDFRRWMDEHLNVKIPRLVDVI-CASPGDQRGKSIVSLELTTCVSDVTAVILF 832
Query: 585 --TIVATMLVLAVTVTSLCSYLDLPWYLRMVCQWTQTRRRARNIPLEELQRNLQFH-AFI 641
T T +V+ + Y D+ W++ VC A+ L + F+ A+I
Sbjct: 833 FFTFFITTMVMLAALAHHLFYWDV-WFIYNVCL-------AKVKGYRSLSTSQTFYDAYI 884
Query: 642 SYSGHDSF---WVKNELLPNLEK---EGMQICLHERNFVPGKSIVENIITCIEKSYKSIF 695
SY D+ WV NEL +LE+ + + +CL ER++ PG +I++N++ I +S K++F
Sbjct: 885 SYDTKDASVTDWVINELRYHLEESRDKNVLLCLEERDWDPGLAIIDNLMQSINQSKKTVF 944
Query: 696 VLSPNFVQSEWCHYELYFAHHNLFHEGSNSLILILLEPIPQYSIPSSYHKLKSLMARRTY 755
VL+ + +S Y A L E + +I ILLEP+ Q+ S Y +L+ + + +
Sbjct: 945 VLTKKYAKSWNFKTAFYLALQRLMDENMDVIIFILLEPVLQH---SQYLRLRQRICKSSI 1001
Query: 756 LEWPKEKSKRGLFWANLRAAINIKLTE 782
L+WP GLFW LR N+ LTE
Sbjct: 1002 LQWPDNPKAEGLFWQTLR---NVVLTE 1025
>gi|19924149 toll-like receptor 4 precursor [Homo sapiens]
Length = 839
Score = 146 bits (369), Expect = 6e-35
Identities = 199/775 (25%), Positives = 324/775 (41%), Gaps = 125/775 (16%)
Query: 43 LSQKTTILNISQNYISELWTSDILSLSKLRILIISHNRIQYLDISVFKFN-QELEYLDLS 101
LS ++ + N ++ L I L L+ L ++HN IQ + + N LE+LDLS
Sbjct: 125 LSSLQKLVAVETN-LASLENFPIGHLKTLKELNVAHNLIQSFKLPEYFSNLTNLEHLDLS 183
Query: 102 HNKLVKISC--------HPTVNLKHLDLSFNAFDALPICKEFGNMSQLKFLGLS------ 147
NK+ I C P +NL LDLS N + + + G +++ L+
Sbjct: 184 SNKIQSIYCTDLRVLHQMPLLNLS-LDLSLNPMNFI----QPGAFKEIRLHKLTLRNNFD 238
Query: 148 TTHLEKSSVLPIAHLNISKVLLVLGETYGE-------KEDPEGLQDFNTESLHIVF---- 196
+ ++ K+ + +A L + + LVLGE E K EGL + E + +
Sbjct: 239 SLNVMKTCIQGLAGLEVHR--LVLGEFRNEGNLEKFDKSALEGLCNLTIEEFRLAYLDYY 296
Query: 197 --PTNKEFHFILDVSVKTVANLELSNIKCVLEDNKCSYFLSILAKLQTNPKLSNLTLNNI 254
F+ + +VS ++ ++ + +K + + + K P L +L +
Sbjct: 297 LDDIIDLFNCLTNVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFGQFPTLKLKSLKRL 356
Query: 255 ETTWNSFIRILQLVWHTTVWYFSISNVKLQGQLDFRDFDYSGTSLKALSIHQVVSDVFGF 314
T N + S V L L+F D +G S K SD
Sbjct: 357 TFTSNKGGN-------------AFSEVDLP-SLEFLDLSRNGLSFKGCCSQ---SD---- 395
Query: 315 PQSYIYEIFSNMNIKNFTVSGTRMVHMLCPSKISPFLHLDFSNNLLTDTVFENCGHLTEL 374
F ++K +L L F+ + T+ N L +L
Sbjct: 396 --------FGTTSLK--------------------YLDLSFNGVI---TMSSNFLGLEQL 424
Query: 375 ETLILQMNQLKELSKIAEMTTQMKSLQQLDISQNSVSYDEKKGDCSWTKSLLSLNMSSNI 434
E L Q + LK++S+ + + +++L LDIS G + SL L M+ N
Sbjct: 425 EHLDFQHSNLKQMSEFS-VFLSLRNLIYLDISHTHTRV-AFNGIFNGLSSLEVLKMAGNS 482
Query: 435 LTDTIFRCLPPRIK---VLDLHSNKIKSI-PKQVVKLEALQELNVAFNSLTDLPGCGSFS 490
+ + ++ LDL +++ + P L +LQ LN++ N+ L
Sbjct: 483 FQENFLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKC 542
Query: 491 SLSVLIIDHNSVSHPSADFFQSCQKMRS----IKAGDNPFQCTCELGEFVKNIDQVSSEV 546
S+ ++D+ S++H Q Q S + N F CTCE F++ I +
Sbjct: 543 LNSLQVLDY-SLNHIMTSKKQELQHFPSSLAFLNLTQNDFACTCEHQSFLQWIKDQRQLL 601
Query: 547 LEGWPDSYKCDYPESYRGTLLKDFHMSELSCNITLLIVTIVATMLVLAVTVTSLCSYLDL 606
+E + +C P +G M LS NIT + + + VL+V V S+ + L
Sbjct: 602 VE--VERMECATPSDKQG-------MPVLSLNITCQMNKTIIGVSVLSVLVVSVVAVLVY 652
Query: 607 PWYLR-MVCQWTQTRRRARNIPLEELQRNLQFHAFISYSGHDSFWVKNELLPNLEKEGM- 664
+Y M+ R NI + AF+ YS D WV+NEL+ NLE EG+
Sbjct: 653 KFYFHLMLLAGCIKYGRGENI----------YDAFVIYSSQDEDWVRNELVKNLE-EGVP 701
Query: 665 --QICLHERNFVPGKSIVENII-TCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFHE 721
Q+CLH R+F+PG +I NII KS K I V+S +F+QS WC +E A F
Sbjct: 702 PFQLCLHYRDFIPGVAIAANIIHEGFHKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLS 761
Query: 722 GSNSLILILLEPIPQYSIPSSYHKLKSLMARRTYLEWPKEKSKRGLFWANLRAAI 776
+I I+L+ + + ++ +L L++R TYLEW R +FW LR A+
Sbjct: 762 SRAGIIFIVLQKV-EKTLLRQQVELYRLLSRNTYLEWEDSVLGRHIFWRRLRKAL 815
>gi|7706093 toll-like receptor 7 [Homo sapiens]
Length = 1049
Score = 131 bits (329), Expect = 3e-30
Identities = 188/803 (23%), Positives = 326/803 (40%), Gaps = 150/803 (18%)
Query: 67 SLSKLRILIISHNRIQYLDISVFKFNQELEYLDLSHNKLVKIS-----CHPTVNLKHLDL 121
+L++L++L + N +Q++ FK +L+ LDLS N L K H +L LDL
Sbjct: 288 ALTELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDL 347
Query: 122 SFNAFDALPICKEFGNMSQLKFLGLSTTHLEKSSVLPIAHLNISKVLLVLGETYGEKEDP 181
SFN L + + N+SQ + L K+L + G + E
Sbjct: 348 SFNF--ELQVYRASMNLSQA-----------------FSSLKSLKILRIRGYVFKE---- 384
Query: 182 EGLQDFNTESLHIVFPTNKEFHFILDVSVKTVANLELSNIKCVLEDNKCSYFLSILAKLQ 241
L+ FN LH N + +LD+ + +++N+ + + + K+
Sbjct: 385 --LKSFNLSPLH-----NLQNLEVLDLGTNFI---KIANLSMFKQFKRLKVIDLSVNKIS 434
Query: 242 TNPKLSNLTL-NNIETTWNSFIRILQLVWHTTVWYFSISNVKLQGQLDFRDFDYSGTSLK 300
+ S + +N T+ S+ + H YF + ++ + +
Sbjct: 435 PSGDSSEVGFCSNARTSVESYEPQVLEQLH----YFRYDKYARSCRFKNKEASFMSVNES 490
Query: 301 ALSIHQVV----SDVFGFPQSYIYEIFSNMNIKNFTVSGTRMVHMLCPSKISPFL---HL 353
Q + + +F F +S ++ S + N +SG + L S+ P +L
Sbjct: 491 CYKYGQTLDLSKNSIF-FVKSSDFQHLSFLKCLN--LSGNLISQTLNGSEFQPLAELRYL 547
Query: 354 DFSNN---LLTDTVFENCGHLTELETLILQMN----QLKELSKIAEMTTQMKSLQQLDIS 406
DFSNN LL T FE L +LE L + N Q + ++ + T +K LQ+L ++
Sbjct: 548 DFSNNRLDLLHSTAFEE---LHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMN 604
Query: 407 QNSVSYDEKKG----------------DCSWT----------KSLLSLNM------SSNI 434
N +S + D W K+LL L S +
Sbjct: 605 DNDISSSTSRTMESESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKNSLSF 664
Query: 435 LTDTIFRCLPPRIKVLDLHSNKIKSIP-KQVVKLEALQELNVAFNSLTDLPGCGSFSSLS 493
L +F +PP +K L L N +KS K++ L+ L+ L+++ N LT +P S S S
Sbjct: 665 LPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRS 724
Query: 494 V--LIIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQ------------------------ 527
+ LI+ +N + + F Q ++R + N Q
Sbjct: 725 LKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHNR 784
Query: 528 --CTCELGEFVKNIDQVSSEVLEGWPDSYKCDYPESYRG--TLLKDFHMSELSCNITLLI 583
CTC+ FV ++ + D C P +++G + D + EL +L
Sbjct: 785 FLCTCDAVWFVWWVNHTEVTIPYLATD-VTCVGPGAHKGQSVISLDLYTCELDLTNLILF 843
Query: 584 VTIVATMLVLAVTVTSLCSYLDLPWYLRMVCQWTQTRRRARNIPLEELQRNLQ----FHA 639
++ L L V +T+ Y WY+ C+ ++ QR + + A
Sbjct: 844 SLSISVSLFLMVMMTASHLYFWDVWYIYHFCK----------AKIKGYQRLISPDCCYDA 893
Query: 640 FISYSGHD---SFWVKNELLPNLE---KEGMQICLHERNFVPGKSIVENIITCIEKSYKS 693
FI Y D + WV EL+ LE ++ +CL ER+++PG+ ++EN+ I+ S K+
Sbjct: 894 FIVYDTKDPAVTEWVLAELVAKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKT 953
Query: 694 IFVLSPNFVQSEWCHYELYFAHHNLFHEGSNSLILILLEPIPQYSIPSSYHKLKSLMARR 753
+FV++ + ++E Y +H L E + +ILI LE Q S + +L+ +
Sbjct: 954 VFVMTDKYAKTENFKIAFYLSHQRLMDEKVDVIILIFLEKPFQ---KSKFLQLRKRLCGS 1010
Query: 754 TYLEWPKEKSKRGLFWANLRAAI 776
+ LEWP FW L+ A+
Sbjct: 1011 SVLEWPTNPQAHPYFWQCLKNAL 1033
Score = 42.0 bits (97), Expect = 0.002
Identities = 106/475 (22%), Positives = 186/475 (39%), Gaps = 79/475 (16%)
Query: 17 IRIQLSEESEFLVDRSKNGLIHVPKDLSQKTTILNISQNYISELWT---SDILSLSKLRI 73
I++ LS E V R+ L L + IL I EL + S + +L L +
Sbjct: 343 IQLDLSFNFELQVYRASMNLSQAFSSL-KSLKILRIRGYVFKELKSFNLSPLHNLQNLEV 401
Query: 74 LIISHNRIQYLDISVFKFNQELEYLDLSHNKL--------VKISCHPTVNLKHLD----- 120
L + N I+ ++S+FK + L+ +DLS NK+ V + +++ +
Sbjct: 402 LDLGTNFIKIANLSMFKQFKRLKVIDLSVNKISPSGDSSEVGFCSNARTSVESYEPQVLE 461
Query: 121 -LSFNAFDALPICKEFGNMSQLKFLGLS--------TTHLEKSSVL-----PIAHLNISK 166
L + +D F N + F+ ++ T L K+S+ HL+ K
Sbjct: 462 QLHYFRYDKYARSCRFKN-KEASFMSVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLK 520
Query: 167 VLLVLGETYGEKEDPEGLQ--------DFNTESLHIVFPTNKEFHFILDVSVKTVANLEL 218
L + G + + Q DF+ L ++ T E L+V L++
Sbjct: 521 CLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHSTAFEELHKLEV-------LDI 573
Query: 219 SNIKCVLEDNKCSYFLSILAKLQTNPKL----SNLTLNNIETTWNSFIRILQLVW-HTTV 273
S+ + ++ L+ L+ KL ++++ + T + +R L+ H V
Sbjct: 574 SSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSRTMESESLRTLEFRGNHLDV 633
Query: 274 WYFSISNVKLQ---GQLDFRDFDYSGTSLKALSIHQVVSDVF-GFPQSYIYEIFSNMNIK 329
+ N LQ L + D S SL L S VF G P + N+++
Sbjct: 634 LWREGDNRYLQLFKNLLKLEELDISKNSLSFLP-----SGVFDGMPPN-----LKNLSLA 683
Query: 330 NFTVSGTRMVHMLCPSKISPFLHLDFSNNLLTDTV--FENCGHLTELETLILQMNQLKEL 387
+ + C + LD S+N LT NC L+ LIL+ NQ++ L
Sbjct: 684 KNGLKSFSWKKLQCLKNLET---LDLSHNQLTTVPERLSNCSR--SLKNLILKNNQIRSL 738
Query: 388 SKIAEMTTQMKSLQQLDISQNSVSYDEKKGDCSWTKSLLSLNMSSNILTDTIFRC 442
+K L+ LD+S N + +K S+ +++L+ N+ +L F C
Sbjct: 739 TKY--FLQDAFQLRYLDLSSNKIQMIQK---TSFPENVLN-NLKMLLLHHNRFLC 787
Score = 33.1 bits (74), Expect = 1.0
Identities = 41/155 (26%), Positives = 67/155 (43%), Gaps = 16/155 (10%)
Query: 374 LETLILQMNQLKELSKIAEMTTQMKSLQQLDISQNSVSYDEKKGDCSWTKSLLSLNMSSN 433
L L L N + ++ + + + LQ LD+S N C+ K+ L + N
Sbjct: 227 LTELYLYNNMIAKIQE--DDFNNLNQLQILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVN 284
Query: 434 ILTDTIFRCLPPRIKVLDLHSNKIKSIPKQVVK-LEALQELNVAFNSLTDLPGCGSF--- 489
D + +KVL LHSN ++ +P + K + LQEL+++ N L G F
Sbjct: 285 AF-DAL-----TELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHF 338
Query: 490 -SSLSVLIIDHN---SVSHPSADFFQSCQKMRSIK 520
SL L + N V S + Q+ ++S+K
Sbjct: 339 LPSLIQLDLSFNFELQVYRASMNLSQAFSSLKSLK 373
>gi|16751843 toll-like receptor 5 [Homo sapiens]
Length = 858
Score = 125 bits (314), Expect = 2e-28
Identities = 118/476 (24%), Positives = 216/476 (45%), Gaps = 51/476 (10%)
Query: 327 NIKNFTVSGTRMVHMLCPSKISPFLHLDFSNNLLTDTVFENCGHLTELETLILQMNQLKE 386
+I + +SG ++V + + + +HL N L + + L+ LIL N+
Sbjct: 404 SIPDIFLSGNKLVTLPKINLTANLIHLS-ENRLENLDILYFLLRVPHLQILILNQNRFSS 462
Query: 387 LSKIAEMTTQMKSLQQLDISQNSVSYDEKKGDCSWTKSLLSLNMSSNILTDTIFRCLPPR 446
S + ++ SL+QL + +N +L L + + D +F L
Sbjct: 463 CSG-DQTPSENPSLEQLFLGEN----------------MLQLAWETELCWD-VFEGLS-H 503
Query: 447 IKVLDLHSNKIKSIPKQVVK-LEALQELNVAFNSLTDLPGCGSFSSLSVLIIDHNSVSHP 505
++VL L+ N + S+P V L AL+ L++ N LT L ++L +L I N + P
Sbjct: 504 LQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLAP 563
Query: 506 SADFFQSCQKMRSIKAGDNPFQCTCELGEFVKNIDQVSSEVLEGWPDSYKCDYPESYRGT 565
+ D F S + + N F C CEL F+ ++ ++ + G P C YP+S+ G
Sbjct: 564 NPDVFVS---LSVLDITHNKFICECELSTFINWLNH-TNVTIAGPPADIYCVYPDSFSGV 619
Query: 566 LLKDFHMSELSCN---------ITLLIV-TIVATMLVLAV-TVTSLCSYLDLPWYLRMVC 614
L F +S C+ +L IV T+ T+ ++ + TVT + +C
Sbjct: 620 SL--FSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTVTKFRGFC-------FIC 670
Query: 615 QWTQTRRRARNIPLEELQRNLQFHAFISYSGHDSFWVKNELLPNLEKE-----GMQICLH 669
T R ++ P ++ A++ +S D WV+N LL +L+ + +C
Sbjct: 671 YKTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYSDQNRFNLCFE 730
Query: 670 ERNFVPGKSIVENIITCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFHEGSNSLILI 729
ER+FVPG++ + NI I S K + ++S +F++ WC +A + +++LI++
Sbjct: 731 ERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCLSDLNSALIMV 790
Query: 730 LLEPIPQYSIPSSYHKLKSLMARRTYLEWPKEKSKRGLFWANLRAAINIKLTEQAK 785
++ + QY + + ++ + ++ YL WP++ G F L I K E+ K
Sbjct: 791 VVGSLSQYQL-MKHQSIRGFVQKQQYLRWPEDLQDVGWFLHKLSQQILKKEKEKKK 845
Score = 47.8 bits (112), Expect = 4e-05
Identities = 36/120 (30%), Positives = 56/120 (46%), Gaps = 11/120 (9%)
Query: 49 ILNISQNYISELWTSDILSLSKLRILIISHNRIQYLDISVFKFNQELEYLDLSHNKLVKI 108
+LN+S N + EL++S+ L K+ + + N I + FKF ++L+ LDL N L I
Sbjct: 340 VLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTI 399
Query: 109 SCHPTVNLKHLDLSFNAFDALPICKEFGNMSQLKFLGLSTTHLEKSSV----LPIAHLNI 164
P++ + LS N LP N+ + LS LE + L + HL I
Sbjct: 400 HFIPSI--PDIFLSGNKLVTLPKINLTANL-----IHLSENRLENLDILYFLLRVPHLQI 452
Score = 38.1 bits (87), Expect = 0.032
Identities = 33/108 (30%), Positives = 55/108 (50%), Gaps = 11/108 (10%)
Query: 19 IQLSEESEFLVDRSKNGLIHVPKDLSQKTTILNISQNYISELWTSDILSLSKLRILIISH 78
+QL+ E+E D + GL H+ +L ++ NY++ L L+ LR L ++
Sbjct: 485 LQLAWETELCWDVFE-GLSHLQ--------VLYLNHNYLNSLPPGVFSHLTALRGLSLNS 535
Query: 79 NRIQYLDISVFKFNQELEYLDLSHNKLVKISCHPTVNLKHLDLSFNAF 126
NR+ L + N LE LD+S N+L+ + V+L LD++ N F
Sbjct: 536 NRLTVLSHNDLPAN--LEILDISRNQLLAPNPDVFVSLSVLDITHNKF 581
Score = 37.7 bits (86), Expect = 0.042
Identities = 26/89 (29%), Positives = 50/89 (56%), Gaps = 4/89 (4%)
Query: 66 LSLSKLRILIISHNRIQYLDISVFKFNQELEYLDLSHNKLVKI---SCHPTVNLKHLDLS 122
L+ S +R L +SH + L+ VF+ ++L+ L+L++NK+ KI + + NL+ L+LS
Sbjct: 285 LARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLS 344
Query: 123 FNAFDALPICKEFGNMSQLKFLGLSTTHL 151
+N L F + ++ ++ L H+
Sbjct: 345 YNLLGEL-YSSNFYGLPKVAYIDLQKNHI 372
Score = 35.0 bits (79), Expect = 0.27
Identities = 24/81 (29%), Positives = 41/81 (50%), Gaps = 6/81 (7%)
Query: 50 LNISQNYISELWTSDIL-----SLSKLRILIISHNRIQYLDISVFKFNQELEYLDLSHNK 104
L + +N + W +++ LS L++L ++HN + L VF L L L+ N+
Sbjct: 478 LFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNR 537
Query: 105 LVKISCHP-TVNLKHLDLSFN 124
L +S + NL+ LD+S N
Sbjct: 538 LTVLSHNDLPANLEILDISRN 558
>gi|4507531 toll-like receptor 3 [Homo sapiens]
Length = 904
Score = 118 bits (296), Expect = 2e-26
Identities = 186/892 (20%), Positives = 350/892 (39%), Gaps = 159/892 (17%)
Query: 25 SEFLVDRSKNGLIHVPKDLSQKTTILNISQNYISELWTSDILSLSKLRILIISHNRIQYL 84
S + D S L VP DL T+LN++ N + L ++ S+L L + N I L
Sbjct: 31 SHEVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISKL 90
Query: 85 DISVFKFNQELEYLDLSHNKLVKISCHP---TVNLKHLDLSFNAFDAL---PICKEFGNM 138
+ + + L+ L+L HN+L ++S NL L L N+ + P K+ +
Sbjct: 91 EPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLI 150
Query: 139 S-QLKFLGLSTTHLEKSSVLPIAHLNISKVLLVLGETYGEKED----------------P 181
+ L GLS+T L L N+ ++LL + K +
Sbjct: 151 TLDLSHNGLSSTKLGTQVQLE----NLQELLLSNNKIQALKSEELDIFANSSLKKLELSS 206
Query: 182 EGLQDFNTESLHIV------FPTNKEF------HFILDVSVKTVANLELSNIKCVLEDNK 229
+++F+ H + F N + L+++ ++ NL LSN + N
Sbjct: 207 NQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSN- 265
Query: 230 CSYFLSILAKLQTNPKLSNLTLNNIETTWNSFIRILQLVWHTTVWYFSISNV---KLQGQ 286
+ L TN + +L+ NN+ N L + + + Y +I ++ L G
Sbjct: 266 ----TTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGL 321
Query: 287 LDFRDFD----YSGTSLKALSIHQVVSDVFGFPQSYIYEIFSNMNIKNFTVSG--TRMVH 340
+ R + ++ S+ S+ ++ D F F + ++N+++ + G + M
Sbjct: 322 FNVRYLNLKRSFTKQSISLASLPKI--DDFSFQW---LKCLEHLNMEDNDIPGIKSNMFT 376
Query: 341 MLCPSKISPFLHLDFSNNLLTDTVFENCGHLTELETLILQMNQLKELSKIAEMTTQMKSL 400
L K + S LT+ F + H + L L L N++ ++ ++ + + L
Sbjct: 377 GLINLKYLSLSNSFTSLRTLTNETFVSLAH-SPLHILNLTKNKISKIE--SDAFSWLGHL 433
Query: 401 QQLDISQNSVSYDEKKGDCSWTKSLLSLNMSSN---ILTDTIFRCLPP------------ 445
+ LD+ N + + + +++ + +S N LT F +P
Sbjct: 434 EVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVALK 493
Query: 446 -------------RIKVLDLHSNKIKSIPKQVVK-LEALQELNVAFNSLTDL-----PG- 485
+ +LDL +N I +I +++ LE L+ L++ N+L L PG
Sbjct: 494 NVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNNLARLWKHANPGG 553
Query: 486 ----CGSFSSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAG------------------- 522
S L +L ++ N + F+ +++ I G
Sbjct: 554 PIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTLPASVFNNQVSLK 613
Query: 523 ------------------------------DNPFQCTCE-LGEFVKNIDQVSSEVLEGWP 551
NPF CTCE + FV I++ + + E
Sbjct: 614 SLNLQKNLITSVEKKVFGPAFRNLTELDMRFNPFDCTCESIAWFVNWINETHTNIPE-LS 672
Query: 552 DSYKCDYPESYRGTLLKDFHMSELSCNITLLIVTIVATMLVLAVTVTSLCSYLDLPWYLR 611
Y C+ P Y G ++ F S + + ++ T ++L L + + W R
Sbjct: 673 SHYLCNTPPHYHGFPVRLFDTSSCKDSAPFELFFMINTSILLIFIFIVLLIHFE-GW--R 729
Query: 612 MVCQWTQTRRRARNI-PLEELQRNLQFHAFISYSGHDSFWVKNELLPNLEKE--GMQICL 668
+ W + R ++ ++ A+I ++ D WV E ++EKE ++ CL
Sbjct: 730 ISFYWNVSVHRVLGFKEIDRQTEQFEYAAYIIHAYKDKDWVW-EHFSSMEKEDQSLKFCL 788
Query: 669 HERNFVPGKSIVENIITCIEKSYKSIFVLSPNFVQSEWC-HYELYFAHHNLFHEGSNSLI 727
ER+F G +E I+ I++S K IFV++ + ++ C ++++ A + +S+I
Sbjct: 789 EERDFEAGVFELEAIVNSIKRSRKIIFVITHHLLKDPLCKRFKVHHAVQQAIEQNLDSII 848
Query: 728 LILLEPIPQYSIPSSYHKLKSLMARRTYLEWPKEKSKRGLFWANLRAAINIK 779
L+ LE IP Y + + + + L WP +K + G F L+ A+ K
Sbjct: 849 LVFLEEIPDYKLNHALCLRRGMFKSHCILNWPVQKERIGAFRHKLQVALGSK 900
>gi|8394456 toll-like receptor 9 isoform A precursor [Homo sapiens]
Length = 1032
Score = 102 bits (255), Expect = 1e-21
Identities = 183/789 (23%), Positives = 322/789 (40%), Gaps = 138/789 (17%)
Query: 68 LSKLRILIISHNRIQYLDISVFKFNQELEYLDLSHNKLVKI-----SCHPTVNLKHLDLS 122
LS+L L++ + + +L+ S F+ L LDLS N L K + L+ L+LS
Sbjct: 283 LSRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSENFLYKCITKTKAFQGLTQLRKLNLS 342
Query: 123 FN-----AFDALPICKEFGNMSQLK--------FLGLSTTHLEKSSVLPI---------- 159
FN +F L + FG++ LK F L T L + LP+
Sbjct: 343 FNYQKRVSFAHLSLAPSFGSLVALKELDMHGIFFRSLDETTLRPLARLPMLQTLRLQMNF 402
Query: 160 ---AHLNISKVL----------------LVLGETYGEKEDPEG--LQDFNTESLHIVFPT 198
A L I + L T GE + E LQ + + P+
Sbjct: 403 INQAQLGIFRAFPGLRYVDLSDNRISGASELTATMGEADGGEKVWLQPGDLAPAPVDTPS 462
Query: 199 NKEF-------HFILDVSVKTVANLE------LSNIKCVLEDNKCSYFLSILAKLQTNPK 245
+++F +F LD+S + ++ LS+++C+ + C
Sbjct: 463 SEDFRPNCSTLNFTLDLSRNNLVTVQPEMFAQLSHLQCLRLSHNCI-------------- 508
Query: 246 LSNLTLNNIETTWNSFIRILQLVWHTTVWYFSISNVKLQGQLDFRDFDYSGTSLKALSIH 305
+ +N + + +++L L + Y S +L +L+ D Y+
Sbjct: 509 --SQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHSFTELP-RLEALDLSYNSQPFGM---- 561
Query: 306 QVVSDVFGFPQSYIYEIFSNMNIKNFTVSGTRMVHMLCPSKISPFLHLDFSNNLLTDTVF 365
Q V F F ++++ + + +++ LC + + LDFS N L
Sbjct: 562 QGVGHNFSFVAHL--RTLRHLSLAHNNIH-SQVSQQLCSTSLRA---LDFSGNAL----- 610
Query: 366 ENCGHLTELETLILQMNQLKELSKIAEMTTQMKSLQQLDISQNSVSYDEKKGDCSWTKSL 425
GH+ L L Q + L LD+SQN + + + KSL
Sbjct: 611 ---GHMWAEGDLYLHFFQ------------GLSGLIWLDLSQNRLHTLLPQTLRNLPKSL 655
Query: 426 LSLNMSSNILTDTIFRCLP--PRIKVLDLHSNKIKSIPKQVVKLEA-LQELNVAFNSLTD 482
L + N L + L P+++VLDL N++K++ + L+ L+V+ NS++
Sbjct: 656 QVLRLRDNYLAFFKWWSLHFLPKLEVLDLAGNQLKALTNGSLPAGTRLRRLDVSCNSISF 715
Query: 483 L-PGCGSFSS-LSVLIIDHNSVSHPSADFFQS-CQKMRSIKAGDNPFQCTCELGEFVKNI 539
+ PG S + L L + N++ +F ++ + NP C C F+ +
Sbjct: 716 VAPGFFSKAKELRELNLSANALKTVDHSWFGPLASALQILDVSANPLHCACGAA-FMDFL 774
Query: 540 DQVSSEVLEGWPDSYKCDYPESYRGTLL--KDFHMS-ELSCNITLLIVTIVATMLVLAVT 596
+V + V G P KC P +G + +D + + + + ++++A L L V
Sbjct: 775 LEVQAAV-PGLPSRVKCGSPGQLQGLSIFAQDLRLCLDEALSWDCFALSLLAVALGLGVP 833
Query: 597 VTS-LCSYLDLPWYLRMVC-QWTQTRRRARNIPLEELQRNLQFHAFISYSGHDSF---WV 651
+ LC + DL WY +C W R R + L + AF+ + S WV
Sbjct: 834 MLHHLCGW-DL-WYCFHLCLAWLPWRGRQSGRDEDALP----YDAFVVFDKTQSAVADWV 887
Query: 652 KNELLPNLE----KEGMQICLHERNFVPGKSIVENIITCIEKSYKSIFVLSPNFVQSEWC 707
NEL LE + +++CL ER+++PGK++ EN+ + S K++FVL+ S
Sbjct: 888 YNELRGQLEECRGRWALRLCLEERDWLPGKTLFENLWASVYGSRKTLFVLAHTDRVSGLL 947
Query: 708 HYELYFAHHNLFHEGSNSLILILLEPIPQYSIPSSYHKLKSLMARRTYLEWPKEKSKRGL 767
A L + + ++L++L P + S Y +L+ + R++ L WP + S +
Sbjct: 948 RASFLLAQQRLLEDRKDVVVLVILSPDGR---RSRYVRLRQRLCRQSVLLWPHQPSGQRS 1004
Query: 768 FWANLRAAI 776
FWA L A+
Sbjct: 1005 FWAQLGMAL 1013
Score = 53.9 bits (128), Expect = 6e-07
Identities = 132/601 (21%), Positives = 228/601 (37%), Gaps = 145/601 (24%)
Query: 34 NGLIHVPKDLSQKTTILNISQNYISELWTSDILSLSKLRI-------------------- 73
N L VP++L L +S N I +L D+ +L+ LR+
Sbjct: 209 NNLTVVPRNLPSSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNCRRCDHAPNPCMEC 268
Query: 74 --------------------LIISHNRIQYLDISVFKFNQELEYLDLSHNKLVKI----- 108
L++ + + +L+ S F+ L LDLS N L K
Sbjct: 269 PRHFPQLHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSENFLYKCITKTK 328
Query: 109 SCHPTVNLKHLDLSFN-----AFDALPICKEFGNMSQLKFL---GLSTTHLEKSSVLPIA 160
+ L+ L+LSFN +F L + FG++ LK L G+ L+++++ P+A
Sbjct: 329 AFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSFGSLVALKELDMHGIFFRSLDETTLRPLA 388
Query: 161 HLNISKVLLV----------------------------------LGETYGEKEDPE--GL 184
L + + L + L T GE + E L
Sbjct: 389 RLPMLQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNRISGASELTATMGEADGGEKVWL 448
Query: 185 QDFNTESLHIVFPTNKEF-------HFILDVSVKTVANL------ELSNIKCVLEDNKC- 230
Q + + P++++F +F LD+S + + +LS+++C+ + C
Sbjct: 449 QPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTVQPEMFAQLSHLQCLRLSHNCI 508
Query: 231 ------SYFLSILA---------KLQTNPKLSNLTLNNIET---TWNSFIRILQLVWHT- 271
S FL + KL + S L +E ++NS +Q V H
Sbjct: 509 SQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEALDLSYNSQPFGMQGVGHNF 568
Query: 272 -------TVWYFSISNVKLQGQLDFRDFDYSGTSLKALSIH-QVVSDVFGFPQSYIYEIF 323
T+ + S+++ + Q+ + TSL+AL + ++ Y++ F
Sbjct: 569 SFVAHLRTLRHLSLAHNNIHSQVSQQ---LCSTSLRALDFSGNALGHMWAEGDLYLH-FF 624
Query: 324 SNMNIKNFTVSGTRMVHMLCPSKI----SPFLHLDFSNNLLTDTVFENCGHLTELETLIL 379
++ + +H L P + L +N L + + L +LE L L
Sbjct: 625 QGLSGLIWLDLSQNRLHTLLPQTLRNLPKSLQVLRLRDNYLAFFKWWSLHFLPKLEVLDL 684
Query: 380 QMNQLKELSKIAEMTTQMKSLQQLDISQNSVSYDEKKGDCSWTKSLLSLNMSSNIL---T 436
NQLK L+ L++LD+S NS+S+ G S K L LN+S+N L
Sbjct: 685 AGNQLKALTN--GSLPAGTRLRRLDVSCNSISF-VAPGFFSKAKELRELNLSANALKTVD 741
Query: 437 DTIFRCLPPRIKVLDLHSNKIKSIPKQVVKLEALQELNVAFNSLTDLPGCGSFSSLSVLI 496
+ F L +++LD+ +N + ++ L E+ A L CGS L L
Sbjct: 742 HSWFGPLASALQILDVSANPLHCACGAAF-MDFLLEVQAAVPGLPSRVKCGSPGQLQGLS 800
Query: 497 I 497
I
Sbjct: 801 I 801
Score = 38.9 bits (89), Expect = 0.019
Identities = 27/81 (33%), Positives = 43/81 (53%), Gaps = 4/81 (4%)
Query: 27 FLVDRSKNGLIHVPKDLSQKTT---ILNISQNYISELWT-SDILSLSKLRILIISHNRIQ 82
F +D S+N L+ V ++ + + L +S N IS+ S L L+ L++L +SHN++
Sbjct: 475 FTLDLSRNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLD 534
Query: 83 YLDISVFKFNQELEYLDLSHN 103
F LE LDLS+N
Sbjct: 535 LYHEHSFTELPRLEALDLSYN 555
>gi|4504379 leucine-rich repeat-containing G protein-coupled
receptor 5 [Homo sapiens]
Length = 907
Score = 68.9 bits (167), Expect = 2e-11
Identities = 118/477 (24%), Positives = 200/477 (41%), Gaps = 65/477 (13%)
Query: 29 VDRSKNGLIHVPKDLSQKTTILNISQNYISELWTSDILSLSKLRILIISHNRIQYLDISV 88
VD S GL +P +LS T+ L++S N IS+L + + SL L L ++ N + Y+
Sbjct: 50 VDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGA 109
Query: 89 FKFNQELEYLDLSHNKLVKISCHPTVNLKHLD---LSFNAFDAL-PICKEFGNMSQLKFL 144
F L+ L L +N+L + NL+ L L N + P C F + L+ L
Sbjct: 110 FTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSC--FSGLHSLRHL 167
Query: 145 GLSTTHLEKSSVLPIAHLN-ISKVLLVLGETYGEKEDPEGLQDFNTESLHIVFPTNKEFH 203
L L + V L+ + + L L + + + G N SL ++ N H
Sbjct: 168 WLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFG----NLSSLVVLHLHNNRIH 223
Query: 204 FILDVSVKTVANLELSNIKCVLEDNKCSYFLSILAKLQTNPKLSNLTLNNIET-TWNSFI 262
+ + +LE + L N F + + L +N K NNI + +F+
Sbjct: 224 SLGKKCFDGLHSLETLD----LNYNNLDEFPTAIRTL-SNLKELGFHSNNIRSIPEKAFV 278
Query: 263 RILQLVWHTTVWYFSISNVKLQGQLDFRDFDYSGTSLKALSIHQVVSDVFGFPQSYIYEI 322
L+ T+ ++ + ++ G+ F+ L+ L+++ S + FP ++
Sbjct: 279 GNPSLI---TIHFYD-NPIQFVGRSAFQHL----PELRTLTLNG-ASQITEFP-----DL 324
Query: 323 FSNMNIKNFTVSGTRMVHMLCPSKISPFLHLDFSNNLLTDTVFENCGHLTELETLILQMN 382
N+++ T++G ++ + L TV C L L+ L L N
Sbjct: 325 TGTANLESLTLTGAQI-------------------SSLPQTV---CNQLPNLQVLDLSYN 362
Query: 383 QLKELSKIAEMTTQMKSLQQLDISQNSVSYDEKKGDCSWTKSLLSLNMSSN---ILTDTI 439
L++L + + LQ++D+ N + Y+ K SL SLN++ N I+
Sbjct: 363 LLEDLPSF----SVCQKLQKIDLRHNEI-YEIKVDTFQQLLSLRSLNLAWNKIAIIHPNA 417
Query: 440 FRCLPPRIKVLDLHSNKIKSIPKQVVKLEALQELNVAFN-SLTDLPGCGSFSSLSVL 495
F LP IK LDL SN + S P + L L L + N +L L +F L V+
Sbjct: 418 FSTLPSLIK-LDLSSNLLSSFP--ITGLHGLTHLKLTGNHALQSLISSENFPELKVI 471
Score = 41.2 bits (95), Expect = 0.004
Identities = 29/90 (32%), Positives = 49/90 (54%), Gaps = 9/90 (10%)
Query: 443 LPPRIKV----LDLHSNKIKSI-PKQVVKLEALQELNVAFNSLTDLPGCGSFS---SLSV 494
LP + V LDL N I + P + L L+EL +A N+LT +P G+F+ SL V
Sbjct: 60 LPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPK-GAFTGLYSLKV 118
Query: 495 LIIDHNSVSHPSADFFQSCQKMRSIKAGDN 524
L++ +N + H + Q+ + ++S++ N
Sbjct: 119 LMLQNNQLRHVPTEALQNLRSLQSLRLDAN 148
Score = 39.7 bits (91), Expect = 0.011
Identities = 47/204 (23%), Positives = 80/204 (39%), Gaps = 30/204 (14%)
Query: 347 ISPFLHLDFSNNLLTDTVFENCGHLTELETLILQMNQLKELSKIAEMTTQMKSLQQLDIS 406
+S + L NN + + L LETL L N L E + +L++L
Sbjct: 209 LSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRT---LSNLKELGFH 265
Query: 407 QNSVSYDEKKGDCSWTKSLLSLNMSSN---ILTDTIFRCLPP------------------ 445
N++ +K SL++++ N + + F+ LP
Sbjct: 266 SNNIRSIPEKAFVG-NPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFPDL 324
Query: 446 ----RIKVLDLHSNKIKSIPKQVV-KLEALQELNVAFNSLTDLPGCGSFSSLSVLIIDHN 500
++ L L +I S+P+ V +L LQ L++++N L DLP L + + HN
Sbjct: 325 TGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHN 384
Query: 501 SVSHPSADFFQSCQKMRSIKAGDN 524
+ D FQ +RS+ N
Sbjct: 385 EIYEIKVDTFQQLLSLRSLNLAWN 408
Score = 33.9 bits (76), Expect = 0.60
Identities = 29/98 (29%), Positives = 43/98 (43%), Gaps = 1/98 (1%)
Query: 28 LVDRSKNGLIHVPK-DLSQKTTILNISQNYISELWTSDILSLSKLRILIISHNRIQYLDI 86
++D S N L +P + QK +++ N I E+ L LR L ++ N+I +
Sbjct: 356 VLDLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHP 415
Query: 87 SVFKFNQELEYLDLSHNKLVKISCHPTVNLKHLDLSFN 124
+ F L LDLS N L L HL L+ N
Sbjct: 416 NAFSTLPSLIKLDLSSNLLSSFPITGLHGLTHLKLTGN 453
>gi|4504655 interleukin 18 receptor 1 precursor [Homo sapiens]
Length = 541
Score = 67.8 bits (164), Expect = 4e-11
Identities = 66/221 (29%), Positives = 107/221 (48%), Gaps = 31/221 (14%)
Query: 566 LLKDFHMSELSCNITLLIVTIVATMLVLAVTVTSLCSY--LDLPWYLRMVCQWTQTRRRA 623
L++ M+++ ++ + I +LV V + ++C +DL + R + TRR
Sbjct: 313 LVRKADMADIPGHVFTRGMIIAVLILVAVVCLVTVCVIYRVDLVLFYRHL-----TRRD- 366
Query: 624 RNIPLEELQRNLQFHAFISY-------SGHDSFWVKNELLPN-LEKE-GMQICLHERNFV 674
E L + AF+SY +G + + E+LP LEK G ++C+ ER+ V
Sbjct: 367 -----ETLTDGKTYDAFVSYLKECRPENGEEHTFAV-EILPRVLEKHFGYKLCIFERDVV 420
Query: 675 PGKSIVENIITCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFHEGSNSLILILLEPI 734
PG ++V+ I + IEKS + I VLS +++ +E YEL H E +ILI P+
Sbjct: 421 PGGAVVDEIHSLIEKSRRLIIVLSKSYMSNE-VRYELESGLHEALVERKIKIILIEFTPV 479
Query: 735 PQYS-IPSSYHKLKSLMARRTYLEWPKEK--SKRGLFWANL 772
++ +P S LKS L+W +K S FW NL
Sbjct: 480 TDFTFLPQSLKLLKS----HRVLKWKADKSLSYNSRFWKNL 516
>gi|197333706 leucine rich repeat containing 8 family, member D
[Homo sapiens]
Length = 858
Score = 65.5 bits (158), Expect = 2e-10
Identities = 65/253 (25%), Positives = 115/253 (45%), Gaps = 37/253 (14%)
Query: 322 IFSNMNIKNFTVSGTRMVHMLCPSKISPFLHLDFSNNLLTDTVFENCGHLTELE-----T 376
+ N+N +N + G + L KI LH+ + + + + HLT+L T
Sbjct: 567 LIGNLNSENNKMIGLESLRELRHLKI---LHVKSNLTKVPSNITDVAPHLTKLVIHNDGT 623
Query: 377 LILQMNQLKELSKIAEMTTQ-------------MKSLQQLDISQNSVSYDEKKGDCSWTK 423
+L +N LK++ +AE+ Q + +LQ+LD+ N++ E+ K
Sbjct: 624 KLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLK 683
Query: 424 SLLSLNMSSNILTDTIFRCLPPRI------KVLDLHSNKIKSIPKQVVKLEALQELNVAF 477
L L + N + +PP I + L +NK++S+P V L+ L+ L+V++
Sbjct: 684 RLTCLKLWHNKIV-----TIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSY 738
Query: 478 NSLTDLP-GCGSFSSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQCTCELGEFV 536
N+++ +P G +L L I N V F+ C K+R++ G N C L E V
Sbjct: 739 NNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFK-CIKLRTLNLGQN---CITSLPEKV 794
Query: 537 KNIDQVSSEVLEG 549
+ Q++ L+G
Sbjct: 795 GQLSQLTQLELKG 807
Score = 40.8 bits (94), Expect = 0.005
Identities = 34/124 (27%), Positives = 62/124 (50%), Gaps = 8/124 (6%)
Query: 34 NGLIHVPKDLSQKTTI--LNISQNYISELWTSDILSLSKLRILIISHNRIQYLDISVFKF 91
N ++ +P ++ + L S N + L + + SL KLR L +S+N I + I +
Sbjct: 693 NKIVTIPPSITHVKNLESLYFSNNKLESLPVA-VFSLQKLRCLDVSYNNISMIPIEI-GL 750
Query: 92 NQELEYLDLSHNK--LVKISCHPTVNLKHLDLSFNAFDALPICKEFGNMSQLKFLGLSTT 149
Q L++L ++ NK ++ + L+ L+L N +LP ++ G +SQL L L
Sbjct: 751 LQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLP--EKVGQLSQLTQLELKGN 808
Query: 150 HLEK 153
L++
Sbjct: 809 CLDR 812
>gi|34222199 leucine rich repeat containing 8 family, member D [Homo
sapiens]
Length = 858
Score = 65.5 bits (158), Expect = 2e-10
Identities = 65/253 (25%), Positives = 115/253 (45%), Gaps = 37/253 (14%)
Query: 322 IFSNMNIKNFTVSGTRMVHMLCPSKISPFLHLDFSNNLLTDTVFENCGHLTELE-----T 376
+ N+N +N + G + L KI LH+ + + + + HLT+L T
Sbjct: 567 LIGNLNSENNKMIGLESLRELRHLKI---LHVKSNLTKVPSNITDVAPHLTKLVIHNDGT 623
Query: 377 LILQMNQLKELSKIAEMTTQ-------------MKSLQQLDISQNSVSYDEKKGDCSWTK 423
+L +N LK++ +AE+ Q + +LQ+LD+ N++ E+ K
Sbjct: 624 KLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLK 683
Query: 424 SLLSLNMSSNILTDTIFRCLPPRI------KVLDLHSNKIKSIPKQVVKLEALQELNVAF 477
L L + N + +PP I + L +NK++S+P V L+ L+ L+V++
Sbjct: 684 RLTCLKLWHNKIV-----TIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSY 738
Query: 478 NSLTDLP-GCGSFSSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQCTCELGEFV 536
N+++ +P G +L L I N V F+ C K+R++ G N C L E V
Sbjct: 739 NNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFK-CIKLRTLNLGQN---CITSLPEKV 794
Query: 537 KNIDQVSSEVLEG 549
+ Q++ L+G
Sbjct: 795 GQLSQLTQLELKG 807
Score = 40.8 bits (94), Expect = 0.005
Identities = 34/124 (27%), Positives = 62/124 (50%), Gaps = 8/124 (6%)
Query: 34 NGLIHVPKDLSQKTTI--LNISQNYISELWTSDILSLSKLRILIISHNRIQYLDISVFKF 91
N ++ +P ++ + L S N + L + + SL KLR L +S+N I + I +
Sbjct: 693 NKIVTIPPSITHVKNLESLYFSNNKLESLPVA-VFSLQKLRCLDVSYNNISMIPIEI-GL 750
Query: 92 NQELEYLDLSHNK--LVKISCHPTVNLKHLDLSFNAFDALPICKEFGNMSQLKFLGLSTT 149
Q L++L ++ NK ++ + L+ L+L N +LP ++ G +SQL L L
Sbjct: 751 LQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLP--EKVGQLSQLTQLELKGN 808
Query: 150 HLEK 153
L++
Sbjct: 809 CLDR 812
>gi|4504661 interleukin 1 receptor accessory protein isoform 1 [Homo
sapiens]
Length = 570
Score = 62.8 bits (151), Expect = 1e-09
Identities = 65/260 (25%), Positives = 121/260 (46%), Gaps = 41/260 (15%)
Query: 536 VKNIDQVSSEVLEGWPDSYKCDYPESYRGTLLKDFHMS----------ELSCNITLLIVT 585
+ +I +V+SE L+ SY C + S +G + K + EL+C ++
Sbjct: 315 ILSIKKVTSEDLKR---SYVC-HARSAKGEVAKAAKVKQKVPAPRYTVELACGFGATVLL 370
Query: 586 IVATMLVLAVTVTSLCSYLDLPWYLRMVCQWTQTRRRARNIPLEELQRNLQFHAFISYS- 644
+V ++V V ++L MV + RA E + ++ ++SY+
Sbjct: 371 VVILIVVYHV------------YWLEMVLFY-----RAHFGTDETILDGKEYDIYVSYAR 413
Query: 645 -GHDSFWVKNELLPNLEKE-GMQICLHERNFVPGKSIVENIITCIEKSYKSIFVLSPNFV 702
+ +V L LE E G ++C+ +R+ +PG + + ++ I+KS + + VLSPN+V
Sbjct: 414 NAEEEEFVLLTLRGVLENEFGYKLCIFDRDSLPGGIVTDETLSFIQKSRRLLVVLSPNYV 473
Query: 703 -QSEWCHYELYFAHHNLFHEGSNSLILILLEPIPQYSIPSSYHKLKSLMARRTYLEWPKE 761
Q EL N+ G+ ++IL+ + + + + +LK T ++W E
Sbjct: 474 LQGTQALLELKAGLENMASRGNINVILVQYKAVKETKV----KELKRAKTVLTVIKWKGE 529
Query: 762 KSK--RGLFWANLRAAINIK 779
KSK +G FW L+ A+ +K
Sbjct: 530 KSKYPQGRFWKQLQVAMPVK 549
>gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
Length = 602
Score = 62.4 bits (150), Expect = 2e-09
Identities = 118/514 (22%), Positives = 214/514 (41%), Gaps = 81/514 (15%)
Query: 48 TILNISQNYISELWTSDILSLSKLRILIISHNRIQYLDISVFKFNQELEYLDLSHNKLVK 107
T+L+I N ++ L S I L L+ L +SHN+++ L + + L+ L L HN+L
Sbjct: 108 TVLDIHDNQLTSL-PSAIRELENLQKLNVSHNKLKILPEEITNL-RNLKCLYLQHNELTC 165
Query: 108 IS--CHPTVNLKHLDLSFNAFDALPICKEFGNMSQLKFLGLSTTHL-----EKSSVLPIA 160
IS NL+ LDLS N +P F ++S L L LS+ L E + + +
Sbjct: 166 ISEGFEQLSNLEDLDLSNNHLTTVPA--SFSSLSSLVRLNLSSNELKSLPAEINRMKRLK 223
Query: 161 HLNISKVLLVLGETYGEKEDPEGLQDFNTESLHIVFPTNKEFHFILDV-SVKTVANLELS 219
HL+ + LL E PE ESL +++ + F+ + S + L +
Sbjct: 224 HLDCNSNLL-------ETIPPELA---GMESLELLYLRRNKLRFLPEFPSCSLLKELHVG 273
Query: 220 NIKC-VLEDNKCSYFLSILAKLQTNPKLSNLTLNNIETTWNSFIRILQLVWHTTVWYFSI 278
+ +LE + SIL + +L N +++ + I +L+ + + I
Sbjct: 274 ENQIEMLEAEHLKHLNSIL--------VLDLRDNKLKSVPDEII-LLRSLERLDLSNNDI 324
Query: 279 SNVKLQ-GQLDFRDFDYSGTSLKALS---IHQVVSDVFGFPQSYIYEIFSNMNIKNFTVS 334
S++ G L + G L+ + I + +V + +S I + + +
Sbjct: 325 SSLPYSLGNLHLKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQS------E 378
Query: 335 GTRMVHMLCPSKISPFLH-------LDFSNN---LLTDTVFENCGHLTELETLILQMNQL 384
M PS+ +H LD+S+ L+ D VF+ + ++ NQL
Sbjct: 379 SATETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVFDAVKS-NIVTSINFSKNQL 437
Query: 385 KELSKIAEMTTQMKSLQQLDISQNSVSYDEKKGDCSWTKSLLSLNMSSNILTDTIFRCLP 444
E+ K M + + +D+S N +S+ +SL + C+
Sbjct: 438 CEIPK--RMVELKEMVSDVDLSFNKLSF-------------ISLEL-----------CVL 471
Query: 445 PRIKVLDLHSNKIKSIPKQVVKLEALQELNVAFNSLTDLPG-CGSFSSLSVLIIDHNSVS 503
++ LDL +N + S+P+++ L LQ +N++FN LP +L ++I +N V
Sbjct: 472 QKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVG 531
Query: 504 HPSADFFQSCQKMRSIKAGDNP-FQCTCELGEFV 536
+ + + ++ +N Q ELG V
Sbjct: 532 SVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCV 565
Score = 50.1 bits (118), Expect = 8e-06
Identities = 32/91 (35%), Positives = 50/91 (54%), Gaps = 4/91 (4%)
Query: 422 TKSLLSLNMSSNILTDTIFRCLPPRIKVLDLHSNKIKSIPKQVVKLEALQELNVAFNSLT 481
TK ++S N ++ D L P + VLD+H N++ S+P + +LE LQ+LNV+ N L
Sbjct: 85 TKLIISNNKLQSLTDDLR---LLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLK 141
Query: 482 DLP-GCGSFSSLSVLIIDHNSVSHPSADFFQ 511
LP + +L L + HN ++ S F Q
Sbjct: 142 ILPEEITNLRNLKCLYLQHNELTCISEGFEQ 172
Score = 38.1 bits (87), Expect = 0.032
Identities = 37/122 (30%), Positives = 60/122 (49%), Gaps = 9/122 (7%)
Query: 29 VDRSKNGLIHVPKDLS--QKTTILNISQNYISELWTSDILSLSKLRILIISHNRIQYLDI 86
+D + N L +P +L+ + +L + +N + L + S S L+ L + N+I+ L+
Sbjct: 225 LDCNSNLLETIPPELAGMESLELLYLRRNKLRFL--PEFPSCSLLKELHVGENQIEMLEA 282
Query: 87 SVFKFNQELEYLDLSHNKLVKISCHPTV--NLKHLDLSFNAFDALPICKEFGNMSQLKFL 144
K + LDL NKL + + +L+ LDLS N +LP GN+ LKFL
Sbjct: 283 EHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPY--SLGNL-HLKFL 339
Query: 145 GL 146
L
Sbjct: 340 AL 341
Score = 34.7 bits (78), Expect = 0.35
Identities = 24/89 (26%), Positives = 45/89 (50%), Gaps = 3/89 (3%)
Query: 44 SQKTTILNISQNYISELWTSDILSLSKLRILIISHNRIQYLDISVFKFNQELEYLDLSHN 103
S T +N S+N + E+ + + + +S N++ ++ + + Q+L +LDL +N
Sbjct: 424 SNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVL-QKLTFLDLRNN 482
Query: 104 KLVKI--SCHPTVNLKHLDLSFNAFDALP 130
L + V L+ ++LSFN F LP
Sbjct: 483 FLNSLPEEMESLVRLQTINLSFNRFKMLP 511
Score = 33.1 bits (74), Expect = 1.0
Identities = 26/101 (25%), Positives = 49/101 (48%), Gaps = 3/101 (2%)
Query: 29 VDRSKNGLIHVPKDLSQKTTILNISQNYISELWTSDIL-SLSKLRILIISHNRIQYLDIS 87
+D N L +P+++ + I+ ++ ++L + L ++IS+N++ +D
Sbjct: 477 LDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQ 536
Query: 88 VFKFNQELEYLDLSHNKLVKI--SCHPTVNLKHLDLSFNAF 126
K + L LDL +N L++I VNL+ L L N F
Sbjct: 537 KMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGNPF 577
>gi|238908508 leucine-rich repeat and death domain-containing
protein [Homo sapiens]
Length = 860
Score = 60.1 bits (144), Expect = 8e-09
Identities = 113/510 (22%), Positives = 212/510 (41%), Gaps = 69/510 (13%)
Query: 28 LVDRSKNGLIHVPKDLSQKTTI--LNISQNYISELWTSDILSLSKLRILIISHNRIQYLD 85
+++ S N + H+PK++SQ I L NYI E + SD+ L L IL + N+++++
Sbjct: 215 ILNVSHNHISHIPKEISQLGNIRQLFFYNNYI-ENFPSDLECLGNLEILSLGKNKLRHIP 273
Query: 86 ISVFKFNQELEYLDLSHNKLV---KISCHPTVNLKHLDLSFNAFDALPICKEFGNMSQLK 142
++ + L L+L +N+L K C L LDL+ N +LP KE + L+
Sbjct: 274 DTLPSL-KTLRVLNLEYNQLTTFPKALCF-LPKLISLDLTGNLISSLP--KEIRELKNLE 329
Query: 143 FLGLSTTHLEKSSVLPIAHLNISKVLLVLGETYGEKEDPEGLQDFNTESLHIVFPTNKEF 202
L + L +V L I ++ L + E ++ + +K
Sbjct: 330 TLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELR------ILILDKNL 383
Query: 203 HFILDVSVKTVANLELSNIKCVLEDNKCSYFLSILAKLQTNPKLSNLTLNNIETTWNSFI 262
+ + A LE + L DNK + + KL L + N+ +
Sbjct: 384 LKNIPEKISCCAMLECLS----LSDNKLTELPKYIHKLN--------NLRKLHVNRNNMV 431
Query: 263 RILQLVWHTTVWYFSISNVKLQGQLDFRDFDYSGTSLKALSIHQVVSDVFGFPQSYIYEI 322
+I + H +I +++ G + K + I + + FP +
Sbjct: 432 KITDCISHLN----NICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLG----L 483
Query: 323 FSNMNIKNFTVSGTRMVHMLCPSKIS---PFLHLDFSNNLLTDTVFENCGHLTELETLIL 379
+ ++ +V+G + + P IS LHL+ S N L E+ L L+ L L
Sbjct: 484 CALDSLYYLSVNGNYISEI--PVDISFSKQLLHLELSENKLL-IFSEHFCSLINLKYLDL 540
Query: 380 QMNQLKEL-SKIAEMTT-------------------QMKSLQQLDISQNSVSYDEKKGDC 419
NQ+K++ + I+ M + +++LQ LD+S+N + + D
Sbjct: 541 GKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQL--QKISSDI 598
Query: 420 SWTKSLLSLNMSSN-ILTDTIFRCLPPRIKVLD---LHSNKIKSIPKQVVKLEALQELNV 475
K + LN SSN + I C ++ L+ + K+ +P ++ + L+EL++
Sbjct: 599 CNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDI 658
Query: 476 AFNSLTDLP-GCGSFSSLSVLIIDHNSVSH 504
+ N++ ++P G +L L +N +S+
Sbjct: 659 SNNAIREIPRNIGELRNLVSLHAYNNQISY 688
Score = 58.9 bits (141), Expect = 2e-08
Identities = 128/511 (25%), Positives = 219/511 (42%), Gaps = 86/511 (16%)
Query: 34 NGLIHVPKDLS--QKTTILNISQNYISELWTSDILSLSKLRILIISHNRIQYLDISVFKF 91
N L PK L K L+++ N IS L +I L L L++ HN++ +L + +F+
Sbjct: 290 NQLTTFPKALCFLPKLISLDLTGNLISSL-PKEIRELKNLETLLMDHNKLTFLAVEIFQL 348
Query: 92 NQELEYLDLSHNKLVKISCHPTVNLKHLD---LSFNAFDALPICKEFGNMSQLKFLGLST 148
+++ L L+ NKL IS H N + L L N +P ++ + L+ L LS
Sbjct: 349 -LKIKELQLADNKLEVIS-HKIENFRELRILILDKNLLKNIP--EKISCCAMLECLSLSD 404
Query: 149 T-------HLEKSSVLPIAHLNISKVLLVLGETYGEKEDPEGLQDFNTESL-HIVFPTNK 200
++ K + L H+N + ++ + T+ + H+ +
Sbjct: 405 NKLTELPKYIHKLNNLRKLHVNRNNMVKI------------------TDCISHLNNICSL 446
Query: 201 EF--HFILDVSVKTVANLELSNIKCVLEDNKCSYF-LSILAKLQTNPKLSNLTLNNIETT 257
EF + I DV ++ + N + IK L NK YF L + A L +L ++
Sbjct: 447 EFSGNIITDVPIE-IKNCQ-KIIKIELSYNKIMYFPLGLCA-------LDSLYYLSVNGN 497
Query: 258 WNSFIRILQLVWHTTVWYFSISNVKLQGQLDFRDFDYSGTSLKALSIHQVVSDVFGFPQS 317
+ S I + + + + + +S KL L F + S +LK L + + + + P S
Sbjct: 498 YISEIPV-DISFSKQLLHLELSENKL---LIFSEHFCSLINLKYLDLGK--NQIKKIPAS 551
Query: 318 YIYEIFSNMNIKNFTVSGTRMVHMLCPSKISPFLH----------LDFSNNLLTDTVFEN 367
SNM + V +LC +K F LD S N L +
Sbjct: 552 -----ISNMISLH--------VLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDI 598
Query: 368 CGHLTELETLILQMNQLKELSKIAEMTTQMKSLQQLDISQ-NSVSYDEKKGDCSWTKSLL 426
C +L ++ L NQ E+ Q++SL+QL+ISQ G+ S L
Sbjct: 599 C-NLKGIQKLNFSSNQFIHFP--IELC-QLQSLEQLNISQIKGRKLTRLPGELSNMTQLK 654
Query: 427 SLNMSSNILTDTIFRCLPPRIKVLDLHS--NKIKSIPKQVVKLEALQELNVAFNSLTDLP 484
L++S+N + + I R + ++ LH+ N+I +P ++ L LQ+LN++ N+LT LP
Sbjct: 655 ELDISNNAIRE-IPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALP 713
Query: 485 GC-GSFSSLSVLIIDHNSVSHPSADFFQSCQ 514
+ SL + D N + P + + Q
Sbjct: 714 SAIYNIFSLKEINFDDNPLLRPPVEICKGKQ 744
Score = 52.8 bits (125), Expect = 1e-06
Identities = 51/208 (24%), Positives = 93/208 (44%), Gaps = 35/208 (16%)
Query: 346 KISPFLHLDFSNNLLTDTVFENCGHLTELETLILQMNQLKELSKIAEMTTQMKSLQQLDI 405
K +L+LD N + + G L LE L LQ N L L ++ + +L+ L++
Sbjct: 164 KYVKYLYLD--KNQIKTFQGADSGDLLGLEILSLQENGLSSLPSEIQL---LHNLRILNV 218
Query: 406 SQNSVSYDEKKGDCSWTKSLLSLNMSSNILTD--TIFRCLPPRIKVLDLHSNKIKSIPKQ 463
S N +S+ K + S ++ L +N + + + CL +++L L NK++ IP
Sbjct: 219 SHNHISHIPK--EISQLGNIRQLFFYNNYIENFPSDLECLG-NLEILSLGKNKLRHIPDT 275
Query: 464 VVKLEALQELNVAFNSLTDLPGCGSF------------------------SSLSVLIIDH 499
+ L+ L+ LN+ +N LT P F +L L++DH
Sbjct: 276 LPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDH 335
Query: 500 NSVSHPSADFFQSCQKMRSIKAGDNPFQ 527
N ++ + + FQ K++ ++ DN +
Sbjct: 336 NKLTFLAVEIFQ-LLKIKELQLADNKLE 362
Score = 44.7 bits (104), Expect = 3e-04
Identities = 45/181 (24%), Positives = 84/181 (46%), Gaps = 19/181 (10%)
Query: 351 LHLDFSNNLLTDTVFENCGHLTELETLILQMNQLKELSKIAEMTTQMKSLQQLDISQNSV 410
+ LD + NL++ E L LETL++ N+L L+ ++K LQ D +
Sbjct: 306 ISLDLTGNLISSLPKE-IRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVI 364
Query: 411 SYDEKKGDCSWTKSLLSLNMSSNILTDTIFRCLPPRI------KVLDLHSNKIKSIPKQV 464
S+ + + L L + N+L + +P +I + L L NK+ +PK +
Sbjct: 365 SHKIEN-----FRELRILILDKNLLKN-----IPEKISCCAMLECLSLSDNKLTELPKYI 414
Query: 465 VKLEALQELNVAFNSLTDLPGCGS-FSSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGD 523
KL L++L+V N++ + C S +++ L N ++ + ++CQK+ I+
Sbjct: 415 HKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIE-IKNCQKIIKIELSY 473
Query: 524 N 524
N
Sbjct: 474 N 474
Score = 41.2 bits (95), Expect = 0.004
Identities = 52/203 (25%), Positives = 97/203 (47%), Gaps = 16/203 (7%)
Query: 1 MTSIFHFAIIFMLILQIRIQLSEESEFL-VDRSKNGLIHVPKDLSQKTTI--LNISQNYI 57
+ S+++ ++ I +I + +S + L ++ S+N L+ + + L++ +N I
Sbjct: 486 LDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQI 545
Query: 58 SELWTSDILSLSKLRILIISHNRIQYLDISVFKFNQELEYLDLSHNKLVKISCHPTVNLK 117
++ S I ++ L +LI+ N+ + + + L+ LDLS N+L KIS NLK
Sbjct: 546 KKIPAS-ISNMISLHVLILCCNKFETFPRELCTL-ENLQVLDLSENQLQKIS-SDICNLK 602
Query: 118 ---HLDLSFNAFDALPI--CK----EFGNMSQLKFLGLSTTHLEKSSVLPIAHLNIS-KV 167
L+ S N F PI C+ E N+SQ+K L+ E S++ + L+IS
Sbjct: 603 GIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNA 662
Query: 168 LLVLGETYGEKEDPEGLQDFNTE 190
+ + GE + L +N +
Sbjct: 663 IREIPRNIGELRNLVSLHAYNNQ 685
>gi|88702793 slit-like 2 [Homo sapiens]
Length = 673
Score = 59.7 bits (143), Expect = 1e-08
Identities = 67/283 (23%), Positives = 115/283 (40%), Gaps = 33/283 (11%)
Query: 352 HLDFSNNLLTDTVFENCGHLTELETLILQMNQLKE--------LSKIAEMTTQMKSLQQL 403
+LD + N L + E L LE L L N+++ L ++ E+ Q L+ L
Sbjct: 104 NLDLTANRLHEITNETFRGLRRLERLYLGKNRIRHIQPGAFDTLDRLLELKLQDNELRAL 163
Query: 404 -----------DISQNSV-SYDEKKGDCSWTKSLLSLNMSSNILTDTIFRCLPPRIKVLD 451
D+S NS+ + + D + ++L + L + +F L + LD
Sbjct: 164 PPLRLPRLLLLDLSHNSLLALEPGILDTANVEALRLAGLGLQQLDEGLFSRLR-NLHDLD 222
Query: 452 LHSNKIKSIPKQVVKLEALQELNVAFNSLT------DLPGCGSFSSLSVLIIDHNSVSHP 505
+ N+++ +P + L L L +A N+ DL G + L V + ++
Sbjct: 223 VSDNQLERVPPVIRGLRGLTRLRLAGNTRIAQLRPEDLAGLAALQELDVSNLSLQALPGD 282
Query: 506 SADFFQSCQKMRSIKAGDNPFQCTCELGEFVKNIDQVSSEVLEGWPDSYKCDYPESYRGT 565
+ F ++R + A NPF C C L F + + S V P+ +C +P G
Sbjct: 283 LSGLFP---RLRLLAAARNPFNCVCPLSWFGPWVRE--SHVTLASPEETRCHFPPKNAGR 337
Query: 566 LLKDFHMSELSCNITLLIVTIVATMLVLAVTVTSLCSYLDLPW 608
LL + ++ C T T+ T V+ T+L S L W
Sbjct: 338 LLLELDYADFGCPATTTTATVPTTRPVVR-EPTALSSSLAPTW 379
Score = 41.6 bits (96), Expect = 0.003
Identities = 35/130 (26%), Positives = 59/130 (45%), Gaps = 4/130 (3%)
Query: 28 LVDRSKNGLIHVPKDLSQ---KTTILNISQNYISELWTSDILSLSKLRILIISHNRIQYL 84
L+D S+N + +P + Q + L+++ N + E+ L +L L + NRI+++
Sbjct: 80 LLDLSQNQIASLPSGVFQPLANLSNLDLTANRLHEITNETFRGLRRLERLYLGKNRIRHI 139
Query: 85 DISVFKFNQELEYLDLSHNKLVKISCHPTVNLKHLDLSFNAFDAL-PICKEFGNMSQLKF 143
F L L L N+L + L LDLS N+ AL P + N+ L+
Sbjct: 140 QPGAFDTLDRLLELKLQDNELRALPPLRLPRLLLLDLSHNSLLALEPGILDTANVEALRL 199
Query: 144 LGLSTTHLEK 153
GL L++
Sbjct: 200 AGLGLQQLDE 209
Score = 38.5 bits (88), Expect = 0.024
Identities = 26/82 (31%), Positives = 42/82 (51%)
Query: 39 VPKDLSQKTTILNISQNYISELWTSDILSLSKLRILIISHNRIQYLDISVFKFNQELEYL 98
VP+D+ T L + +N I+ L L L++L +S N+I L VF+ L L
Sbjct: 46 VPRDVPPDTVGLYVFENGITMLDAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNL 105
Query: 99 DLSHNKLVKISCHPTVNLKHLD 120
DL+ N+L +I+ L+ L+
Sbjct: 106 DLTANRLHEITNETFRGLRRLE 127
Score = 32.0 bits (71), Expect = 2.3
Identities = 22/83 (26%), Positives = 38/83 (45%), Gaps = 3/83 (3%)
Query: 445 PRIKVLDLHSNKIKSIPKQVVK-LEALQELNVAFNSLTDLPG--CGSFSSLSVLIIDHNS 501
P +++LDL N+I S+P V + L L L++ N L ++ L L + N
Sbjct: 76 PGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANRLHEITNETFRGLRRLERLYLGKNR 135
Query: 502 VSHPSADFFQSCQKMRSIKAGDN 524
+ H F + ++ +K DN
Sbjct: 136 IRHIQPGAFDTLDRLLELKLQDN 158
>gi|19743846 decorin isoform a preproprotein [Homo sapiens]
Length = 359
Score = 57.4 bits (137), Expect = 5e-08
Identities = 76/282 (26%), Positives = 116/282 (41%), Gaps = 26/282 (9%)
Query: 28 LVDRSKNGLIHVPKDLSQKTTILNISQNYISELWTSDILSLSKLRILIISHNRIQYLDIS 87
+V S GL VPKDL TT+L++ N I+E+ D +L L LI+ +N+I +
Sbjct: 64 VVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISKVSPG 123
Query: 88 VFKFNQELEYLDLSHNKLVKISCHPTVNLKHLDLSFNAFDALPICKEFGNMSQLKFLGLS 147
F +LE L LS N+L ++ L+ L N + F ++Q+ + L
Sbjct: 124 AFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKV-TFNGLNQMIVIELG 182
Query: 148 TTHLEKSSVLPIAHLNISKVLLVLGETYGEKEDPEGLQDFNTESLHIVFPTNKEFHFILD 207
T L+ S + A + K+ + P+GL TE LH+ + +
Sbjct: 183 TNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTE-LHL---DGNKISRVDA 238
Query: 208 VSVKTVANLELSNIKCVLEDNKCSYFLSILAKLQTNPKLSNLTLNNIETTWNSFIRI--- 264
S+K + NL K L N S + L P L L L+N N R+
Sbjct: 239 ASLKGLNNL----AKLGLSFNSISAVDN--GSLANTPHLRELHLDN-----NKLTRVPGG 287
Query: 265 LQLVWHTTVWYFSISNVKLQGQLDF-------RDFDYSGTSL 299
L + V Y +N+ + G DF + YSG SL
Sbjct: 288 LAEHKYIQVVYLHNNNISVVGSSDFCPPGHNTKKASYSGVSL 329
Score = 38.5 bits (88), Expect = 0.024
Identities = 49/185 (26%), Positives = 85/185 (45%), Gaps = 21/185 (11%)
Query: 353 LDFSNNLLTDTVFENCGHLTELETLILQMNQLKELSKIAEMTTQMKSLQQLDISQNSVSY 412
LD NN +T+ + +L L LIL N++ ++S A T + L++L +S+N +
Sbjct: 86 LDLQNNKITEIKDGDFKNLKNLHALILVNNKISKVSPGA--FTPLVKLERLYLSKNQLKE 143
Query: 413 DEKKGDCSWTKSLLSLNMSSNILT---DTIFRCLPPRIKVLDLHSNKIKSIPKQVVKLEA 469
+K K+L L N +T F L I V++L +N +KS + +
Sbjct: 144 LPEK----MPKTLQELRAHENEITKVRKVTFNGLNQMI-VIELGTNPLKSSGIENGAFQG 198
Query: 470 LQELN---VAFNSLTDLPGCGSFSSLSVLIIDHNSVSHPSADFFQSCQKM-------RSI 519
+++L+ +A ++T +P G SL+ L +D N +S A + + SI
Sbjct: 199 MKKLSYIRIADTNITSIPQ-GLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSI 257
Query: 520 KAGDN 524
A DN
Sbjct: 258 SAVDN 262
Score = 36.6 bits (83), Expect = 0.093
Identities = 42/161 (26%), Positives = 68/161 (42%), Gaps = 34/161 (21%)
Query: 371 LTELETLILQMNQLKELSKIAEMTTQMKSLQQLDISQNSVSYDEK--------------- 415
L +LE L L NQLKEL + K+LQ+L +N ++ K
Sbjct: 128 LVKLERLYLSKNQLKELPE-----KMPKTLQELRAHENEITKVRKVTFNGLNQMIVIELG 182
Query: 416 ----------KGDCSWTKSLLSLNMSSNILTDTIFRCLPPRIKVLDLHSNKIKSIPKQVV 465
G K L + ++ +T +I + LPP + L L NKI + +
Sbjct: 183 TNPLKSSGIENGAFQGMKKLSYIRIADTNIT-SIPQGLPPSLTELHLDGNKISRVDAASL 241
Query: 466 K-LEALQELNVAFNSLT--DLPGCGSFSSLSVLIIDHNSVS 503
K L L +L ++FNS++ D + L L +D+N ++
Sbjct: 242 KGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLT 282
>gi|4503271 decorin isoform a preproprotein [Homo sapiens]
Length = 359
Score = 57.4 bits (137), Expect = 5e-08
Identities = 76/282 (26%), Positives = 116/282 (41%), Gaps = 26/282 (9%)
Query: 28 LVDRSKNGLIHVPKDLSQKTTILNISQNYISELWTSDILSLSKLRILIISHNRIQYLDIS 87
+V S GL VPKDL TT+L++ N I+E+ D +L L LI+ +N+I +
Sbjct: 64 VVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISKVSPG 123
Query: 88 VFKFNQELEYLDLSHNKLVKISCHPTVNLKHLDLSFNAFDALPICKEFGNMSQLKFLGLS 147
F +LE L LS N+L ++ L+ L N + F ++Q+ + L
Sbjct: 124 AFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKV-TFNGLNQMIVIELG 182
Query: 148 TTHLEKSSVLPIAHLNISKVLLVLGETYGEKEDPEGLQDFNTESLHIVFPTNKEFHFILD 207
T L+ S + A + K+ + P+GL TE LH+ + +
Sbjct: 183 TNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTE-LHL---DGNKISRVDA 238
Query: 208 VSVKTVANLELSNIKCVLEDNKCSYFLSILAKLQTNPKLSNLTLNNIETTWNSFIRI--- 264
S+K + NL K L N S + L P L L L+N N R+
Sbjct: 239 ASLKGLNNL----AKLGLSFNSISAVDN--GSLANTPHLRELHLDN-----NKLTRVPGG 287
Query: 265 LQLVWHTTVWYFSISNVKLQGQLDF-------RDFDYSGTSL 299
L + V Y +N+ + G DF + YSG SL
Sbjct: 288 LAEHKYIQVVYLHNNNISVVGSSDFCPPGHNTKKASYSGVSL 329
Score = 38.5 bits (88), Expect = 0.024
Identities = 49/185 (26%), Positives = 85/185 (45%), Gaps = 21/185 (11%)
Query: 353 LDFSNNLLTDTVFENCGHLTELETLILQMNQLKELSKIAEMTTQMKSLQQLDISQNSVSY 412
LD NN +T+ + +L L LIL N++ ++S A T + L++L +S+N +
Sbjct: 86 LDLQNNKITEIKDGDFKNLKNLHALILVNNKISKVSPGA--FTPLVKLERLYLSKNQLKE 143
Query: 413 DEKKGDCSWTKSLLSLNMSSNILT---DTIFRCLPPRIKVLDLHSNKIKSIPKQVVKLEA 469
+K K+L L N +T F L I V++L +N +KS + +
Sbjct: 144 LPEK----MPKTLQELRAHENEITKVRKVTFNGLNQMI-VIELGTNPLKSSGIENGAFQG 198
Query: 470 LQELN---VAFNSLTDLPGCGSFSSLSVLIIDHNSVSHPSADFFQSCQKM-------RSI 519
+++L+ +A ++T +P G SL+ L +D N +S A + + SI
Sbjct: 199 MKKLSYIRIADTNITSIPQ-GLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSI 257
Query: 520 KAGDN 524
A DN
Sbjct: 258 SAVDN 262
Score = 36.6 bits (83), Expect = 0.093
Identities = 42/161 (26%), Positives = 68/161 (42%), Gaps = 34/161 (21%)
Query: 371 LTELETLILQMNQLKELSKIAEMTTQMKSLQQLDISQNSVSYDEK--------------- 415
L +LE L L NQLKEL + K+LQ+L +N ++ K
Sbjct: 128 LVKLERLYLSKNQLKELPE-----KMPKTLQELRAHENEITKVRKVTFNGLNQMIVIELG 182
Query: 416 ----------KGDCSWTKSLLSLNMSSNILTDTIFRCLPPRIKVLDLHSNKIKSIPKQVV 465
G K L + ++ +T +I + LPP + L L NKI + +
Sbjct: 183 TNPLKSSGIENGAFQGMKKLSYIRIADTNIT-SIPQGLPPSLTELHLDGNKISRVDAASL 241
Query: 466 K-LEALQELNVAFNSLT--DLPGCGSFSSLSVLIIDHNSVS 503
K L L +L ++FNS++ D + L L +D+N ++
Sbjct: 242 KGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLT 282
>gi|7657232 interleukin 1 receptor accessory protein-like 1
precursor [Homo sapiens]
Length = 696
Score = 57.4 bits (137), Expect = 5e-08
Identities = 63/269 (23%), Positives = 116/269 (43%), Gaps = 31/269 (11%)
Query: 532 LGEFVKNIDQVSSEVLEGWPDSYKCDYPESYRGTLLKDFHMSELSCNITLLIVTIVATML 591
LGE +I + V EG +Y C Y E+ G + + T+ + + +L
Sbjct: 310 LGEQEVSISLIVDSVEEGDLGNYSC-YVENGNGRRHASVLLHKRELMYTVELAGGLGAIL 368
Query: 592 VLAVTVTSL--CSYLDLPWYLRMVCQWTQTRRRARNIPLEELQR-NLQFHAFISYSGHD- 647
+L V + ++ C +++ + R + EEL N + A++SY+ D
Sbjct: 369 LLLVCLVTIYKCYKIEIMLFYR------------NHFGAEELDGDNKDYDAYLSYTKVDP 416
Query: 648 SFWVKN---------ELLPN-LEKE-GMQICLHERNFVPGKSIVENIITCIEKSYKSIFV 696
W + E+LP+ LEK G ++ + +R+ +P + +E++ C+++S + I V
Sbjct: 417 DQWNQETGEEERFALEILPDMLEKHYGYKLFIPDRDLIPTGTYIEDVARCVDQSKRLIIV 476
Query: 697 LSPNF-VQSEWCHYELYFAHHNLFHEGSNSLILILLEPIPQYSIPSSYHKLKSLMARRTY 755
++PN+ V+ W +EL N+ G +ILI + LK + T
Sbjct: 477 MTPNYVVRRGWSIFELETRLRNMLVTGEIKVILIECSELRGIMNYQEVEALKHTIKLLTV 536
Query: 756 LEW--PKEKSKRGLFWANLRAAINIKLTE 782
++W PK FW L+ + K E
Sbjct: 537 IKWHGPKCNKLNSKFWKRLQYEMPFKRIE 565
>gi|62912470 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 1 [Homo sapiens]
Length = 967
Score = 56.2 bits (134), Expect = 1e-07
Identities = 99/427 (23%), Positives = 169/427 (39%), Gaps = 62/427 (14%)
Query: 30 DRSKNGLIHVPKDLSQKTTILNISQNYISELWTSDILSLSKLRILIISHNRIQYLDISVF 89
D S+ GL VP DL T L++S N ++EL L L L +S N + ++ F
Sbjct: 51 DCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAF 110
Query: 90 KFNQELEYLDLSHNKLVKISCHPT---VNLKHLDLSFNAFDALPICKEFGNMSQLKFLGL 146
L+ L L +N+L I +L+ L L N +P + F +S L+ L L
Sbjct: 111 SGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPE-RSFEGLSSLRHLWL 169
Query: 147 STTHLEKSSVLPIAHLNISKVLLVLGETYGEKEDPEGLQDFNTESLHIVFPTNKEFHFIL 206
L + +P+ LN L + N SL ++ N +
Sbjct: 170 DDNALTE---IPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLG 226
Query: 207 DVSVKTVANLELSNIKCVLEDNKCSYFLSILAKLQTNPKLSNLTL--NNIET-------- 256
S + + NLE + L NK F ++T +L L NNI+
Sbjct: 227 THSFEGLHNLETLD----LNYNKLQEFP---VAIRTLGRLQELGFHNNNIKAIPEKAFMG 279
Query: 257 -----TWNSFIRILQLVWHTTVWYF-SISNVKLQGQLDFRDF-DYSGTSLKALSIHQVVS 309
T + + +Q V + Y + + L G +D ++F D GT+
Sbjct: 280 NPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTT----------- 328
Query: 310 DVFGFPQSYIYEIFSNMNIKNFTVSGTRMVHMLCPSKISPFLHLDFSNNLLTDTVFENCG 369
++ I T +G R++ ++ L+ S+N + + +
Sbjct: 329 ---------------SLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEE--LPSLH 371
Query: 370 HLTELETLILQMNQLKELSKIAEMTTQMKSLQQLDISQNSVSYDEKKGDCSWTKSLLSLN 429
+LE + LQ N++ E+ A+ +Q+ SLQ LD+S N++ + S SL+ L+
Sbjct: 372 RCQKLEEIGLQHNRIWEIG--ADTFSQLSSLQALDLSWNAIRSIHPEA-FSTLHSLVKLD 428
Query: 430 MSSNILT 436
++ N LT
Sbjct: 429 LTDNQLT 435
Score = 39.3 bits (90), Expect = 0.014
Identities = 41/138 (29%), Positives = 71/138 (51%), Gaps = 13/138 (9%)
Query: 32 SKNGLIHVPK--DLSQKTT--ILNISQNYISELWTSDILSLSKLRILIISHNRIQYLDIS 87
S NG + + + DL T+ IL +++ I L + L +LR+L +SHN+I+ ++
Sbjct: 311 SLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIE--ELP 368
Query: 88 VFKFNQELEYLDLSHNKLVKISC---HPTVNLKHLDLSFNAFDALPICKEFGNMSQLKFL 144
Q+LE + L HN++ +I +L+ LDLS+NA ++ + F + L L
Sbjct: 369 SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIH-PEAFSTLHSLVKL 427
Query: 145 GLSTTHLEKSSVLPIAHL 162
L+ L + LP+A L
Sbjct: 428 DLTDNQL---TTLPLAGL 442
Score = 34.3 bits (77), Expect = 0.46
Identities = 24/80 (30%), Positives = 34/80 (42%)
Query: 45 QKTTILNISQNYISELWTSDILSLSKLRILIISHNRIQYLDISVFKFNQELEYLDLSHNK 104
QK + + N I E+ LS L+ L +S N I+ + F L LDL+ N+
Sbjct: 374 QKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQ 433
Query: 105 LVKISCHPTVNLKHLDLSFN 124
L + L HL L N
Sbjct: 434 LTTLPLAGLGGLMHLKLKGN 453
Score = 33.5 bits (75), Expect = 0.78
Identities = 21/83 (25%), Positives = 44/83 (53%), Gaps = 5/83 (6%)
Query: 445 PRIKVLDLHSNKIKSIPKQVVKLEALQELNVAFNSLTDLPGCGSF---SSLSVLIIDHNS 501
PR++VL+L N+I+ +P + + + L+E+ + N + ++ G +F SSL L + N+
Sbjct: 352 PRLRVLELSHNQIEELP-SLHRCQKLEEIGLQHNRIWEI-GADTFSQLSSLQALDLSWNA 409
Query: 502 VSHPSADFFQSCQKMRSIKAGDN 524
+ + F + + + DN
Sbjct: 410 IRSIHPEAFSTLHSLVKLDLTDN 432
Score = 33.1 bits (74), Expect = 1.0
Identities = 40/187 (21%), Positives = 75/187 (40%), Gaps = 28/187 (14%)
Query: 298 SLKALSIHQVVSDVFGFPQSYIYEIFSNMNIKNFTVSGTRMVHMLCPSKISPFLHLDFSN 357
SLK L + + + G P ++E+ S +++ + +V +S HL +
Sbjct: 115 SLKILMLQN--NQLGGIPAEALWELPSLQSLR-LDANLISLVPERSFEGLSSLRHLWLDD 171
Query: 358 NLLTDTVFENCGHLTELETLILQMNQLKELSKIAEMTTQMKSLQQLDISQNSVSYDEKKG 417
N LT+ +L L+ + L +N++ + A + SL L + N + +
Sbjct: 172 NALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQN--LTSLVVLHLHNNRIQH----- 224
Query: 418 DCSWTKSLLSLNMSSNILTDTIFRCLPPRIKVLDLHSNKIKSIPKQVVKLEALQELNVAF 477
T S L+ ++ LDL+ NK++ P + L LQEL
Sbjct: 225 --LGTHSFEGLH----------------NLETLDLNYNKLQEFPVAIRTLGRLQELGFHN 266
Query: 478 NSLTDLP 484
N++ +P
Sbjct: 267 NNIKAIP 273
>gi|11321571 slit homolog 3 [Homo sapiens]
Length = 1523
Score = 55.5 bits (132), Expect = 2e-07
Identities = 43/155 (27%), Positives = 73/155 (47%), Gaps = 15/155 (9%)
Query: 29 VDRSKNGLIHVPKDLSQKTTILNISQNYISELWTSDILSLSKLRILIISHNRIQYLDISV 88
VD GL VP+ + + L++ +N I+ + D L LR+L + N++ ++
Sbjct: 45 VDCHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGA 104
Query: 89 FKFNQELEYLDLSHNK---LVKISCHPTVNLKHLDLSFNAFDALPICKEFGNMSQLKFLG 145
F+ ++LE L L+ NK L ++ T L LDLS N +P K F ++ +K L
Sbjct: 105 FQDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLDLSENQIQGIP-RKAFRGITDVKNLQ 163
Query: 146 LSTTH-----------LEKSSVLPIAHLNISKVLL 169
L H L +L + + NIS++L+
Sbjct: 164 LDNNHISCIEDGAFRALRDLEILTLNNNNISRILV 198
Score = 49.7 bits (117), Expect = 1e-05
Identities = 42/165 (25%), Positives = 83/165 (50%), Gaps = 12/165 (7%)
Query: 375 ETLILQMNQLKELSKIAEMTTQMKSLQQLDISQNSVSYDEKKGDCSWTKSLLSLNMSSN- 433
E L L N + ++K+ +K+L+ L + N VS E+ G K L L ++ N
Sbjct: 64 ERLDLDRNNITRITKMD--FAGLKNLRVLHLEDNQVSVIER-GAFQDLKQLERLRLNKNK 120
Query: 434 --ILTDTIFRCLPPRIKVLDLHSNKIKSIPKQVVK-LEALQELNVAFNSLTDLPGCGSFS 490
+L + +F+ P ++ LDL N+I+ IP++ + + ++ L + N ++ + G+F
Sbjct: 121 LQVLPELLFQSTP-KLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIED-GAFR 178
Query: 491 SL---SVLIIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQCTCEL 532
+L +L +++N++S F K+R+++ N C C L
Sbjct: 179 ALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHL 223
Score = 42.7 bits (99), Expect = 0.001
Identities = 43/157 (27%), Positives = 71/157 (45%), Gaps = 28/157 (17%)
Query: 379 LQMNQLKELSKIAEMTTQMKSLQQLDISQNSVSYDEKKGDCSWTKSLLSLNMSSNILTDT 438
L+ N +K + A TQ K L+++DIS+N +S D KSL SL + N +T+
Sbjct: 314 LEQNSIKAIP--AGAFTQYKKLKRIDISKNQIS-DIAPDAFQGLKSLTSLVLYGNKITEI 370
Query: 439 ---IFRCLPPRIKVLDLHSNKIKSIPKQVVKLEALQELNVAFNSLTDLPGCGSFSSLSVL 495
+F L +++L L++NKI + N+ DL +L++L
Sbjct: 371 AKGLFDGLVS-LQLLLLNANKINCL---------------RVNTFQDL------QNLNLL 408
Query: 496 IIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQCTCEL 532
+ N + S F Q ++++ NPF C C L
Sbjct: 409 SLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHL 445
Score = 38.9 bits (89), Expect = 0.019
Identities = 35/134 (26%), Positives = 60/134 (44%), Gaps = 4/134 (2%)
Query: 25 SEFLVDRSKNGLIHVPKDLSQKTTILNISQNYISELWTSDILSLSKLRILIISHNRIQYL 84
S +VD GL+ +P +L + + + QN I + KL+ + IS N+I +
Sbjct: 287 SNNIVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDI 346
Query: 85 DISVFKFNQELEYLDLSHNKLVKIS---CHPTVNLKHLDLSFNAFDALPICKEFGNMSQL 141
F+ + L L L NK+ +I+ V+L+ L L+ N + L + F ++ L
Sbjct: 347 APDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNANKINCLRV-NTFQDLQNL 405
Query: 142 KFLGLSTTHLEKSS 155
L L L+ S
Sbjct: 406 NLLSLYDNKLQTIS 419
Score = 38.1 bits (87), Expect = 0.032
Identities = 35/129 (27%), Positives = 61/129 (47%), Gaps = 5/129 (3%)
Query: 26 EFLVDRSKNGLIHVPKDLSQKTTILNISQNYISELWTSDILSLSKLRILIISHNRIQYLD 85
E +V S GL +P+ + + T L + N+++ + ++ +L L ++ +S+N I L
Sbjct: 733 ETVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAV-PRELSALRHLTLIDLSNNSISMLT 791
Query: 86 ISVFKFNQELEYLDLSHNKLVKISCHP---TVNLKHLDLSFNAFDALPICKEFGNMSQLK 142
F L L LS+N+L I H +L+ L L N ++P F +++ L
Sbjct: 792 NYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPE-GSFNDLTSLS 850
Query: 143 FLGLSTTHL 151
L L T L
Sbjct: 851 HLALGTNPL 859
Score = 36.6 bits (83), Expect = 0.093
Identities = 42/185 (22%), Positives = 80/185 (43%), Gaps = 18/185 (9%)
Query: 403 LDISQNSVSYDEKKGDCSWTKSLLSLNMSSNILTDTIFRCLPPRIKV--LDLHSNKIKSI 460
L ++ N VS E G +L +N+S+N + + V L L N+++++
Sbjct: 537 LRLNDNEVSVLEATGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLETV 596
Query: 461 PKQVVK-LEALQELNVAFNSLTDLPGCGS------FSSLSVLIIDHNSVSHPSADFFQSC 513
+V + L L+ L + N L GC S SS+ +L + N ++ + F +
Sbjct: 597 HGRVFRGLSGLKTLMLRSN----LIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTL 652
Query: 514 QKMRSIKAGDNPFQCTCELGEFVKNIDQVSSEVLEGWPDSYKCDYPESYRGTLLKDFHMS 573
+ +I NPF C C L K + + ++ G P +C P + ++D +
Sbjct: 653 VSLSTINLLSNPFNCNCHLAWLGKWLRK--RRIVSGNP---RCQKPFFLKEIPIQDVAIQ 707
Query: 574 ELSCN 578
+ +C+
Sbjct: 708 DFTCD 712
Score = 35.4 bits (80), Expect = 0.21
Identities = 31/126 (24%), Positives = 48/126 (38%), Gaps = 12/126 (9%)
Query: 447 IKVLDLHSNKIKSIPKQVVK-LEALQELNVAFNSLTDLP--GCGSFSSLSVLIIDHNSVS 503
+ ++DL +N I + + L L +++N L +P SL VL + N +S
Sbjct: 777 LTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDIS 836
Query: 504 HPSADFFQSCQKMRSIKAGDNPFQCTCELGEFVKNIDQVSSEVLEGW--PDSYKCDYPES 561
F + + G NP C C L +S V G+ P +C PE
Sbjct: 837 SVPEGSFNDLTSLSHLALGTNPLHCDCSL-------RWLSEWVKAGYKEPGIARCSSPEP 889
Query: 562 YRGTLL 567
LL
Sbjct: 890 MADRLL 895
Score = 32.3 bits (72), Expect = 1.7
Identities = 31/98 (31%), Positives = 48/98 (48%), Gaps = 12/98 (12%)
Query: 344 PSKISPFLHL---DFSNN---LLTDTVFENCGHLTELETLILQMNQLKELSKIAEMTTQM 397
P ++S HL D SNN +LT+ F N HL+ TLIL N+L+ + +
Sbjct: 768 PRELSALRHLTLIDLSNNSISMLTNYTFSNMSHLS---TLILSYNRLRCIP--VHAFNGL 822
Query: 398 KSLQQLDISQNSVSYDEKKGDCSWTKSLLSLNMSSNIL 435
+SL+ L + N +S +G + SL L + +N L
Sbjct: 823 RSLRVLTLHGNDIS-SVPEGSFNDLTSLSHLALGTNPL 859
>gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens]
Length = 277
Score = 55.5 bits (132), Expect = 2e-07
Identities = 45/152 (29%), Positives = 76/152 (50%), Gaps = 16/152 (10%)
Query: 385 KELSKIAEMTTQMKSLQQLDISQNSVSYDEKKGDCSWTKSLLSLNMSSNILTDTIFRCLP 444
K L K+ E + + K+ ++D+S +S + L +S N LT +P
Sbjct: 3 KSLKKLVEESRE-KNQPEVDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLT-----MVP 56
Query: 445 PRI------KVLDLHSNKIKSIPKQVVKLEALQELNVAFNSLTDLP-GCGSFSSLSVLII 497
P I +VL+ +N+I+ +P Q+ L+ L+ LN+ N L LP G GS +L VL +
Sbjct: 57 PNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDL 116
Query: 498 DHNSVSHPS--ADFFQSCQKMRSIKAGDNPFQ 527
+N++S S +FF +R++ DN F+
Sbjct: 117 TYNNLSENSLPGNFFY-LTTLRALYLSDNDFE 147
Score = 40.8 bits (94), Expect = 0.005
Identities = 49/154 (31%), Positives = 67/154 (43%), Gaps = 32/154 (20%)
Query: 32 SKNGLIHVPKDLSQ--KTTILNISQNYISELWTSDILSLSKLRILIISHNRIQYLDISVF 89
S N L VP ++++ +LN N I EL T I SL KL+ L + NR+ L F
Sbjct: 48 SHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQ-ISSLQKLKHLNLGMNRLNTLPRG-F 105
Query: 90 KFNQELEYLDLSHNKLVKISCHPT----VNLKHLDLSFNAFDALP--------------- 130
LE LDL++N L + S L+ L LS N F+ LP
Sbjct: 106 GSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLR 165
Query: 131 ------ICKEFGNMSQLKFLGLSTTHLEKSSVLP 158
+ KE G ++QLK L + L +VLP
Sbjct: 166 DNDLISLPKEIGELTQLKELHIQGNRL---TVLP 196
>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
Length = 582
Score = 55.1 bits (131), Expect = 3e-07
Identities = 124/513 (24%), Positives = 216/513 (42%), Gaps = 87/513 (16%)
Query: 23 EESEFLVDRSKNGLIHVP---KDLSQKTTI----------------------LNISQNYI 57
EE+ +D SK + +P K+L+Q T + L +S+N +
Sbjct: 99 EENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSL 158
Query: 58 SELWTSDILSLSKLRILIISHNRIQYLDISVFKFNQELEYLDLSHNKL--VKISCHPTVN 115
+ L S + +L KLR+L + HN+++ + V++ + L L L N++ V+
Sbjct: 159 TSLPDS-LDNLKKLRMLDLRHNKLREIPSVVYRLD-SLTTLYLRFNRITTVEKDIKNLSK 216
Query: 116 LKHLDLSFNAFDALPICKEFGNMSQLKFLGLSTTHLEKSSVLPIAHLNISKVLLVLGETY 175
L L + N LP E G + L L ++ LE HL
Sbjct: 217 LSMLSIRENKIKQLP--AEIGELCNLITLDVAHNQLE--------HL------------- 253
Query: 176 GEKEDPEGLQDFNTESLHIVFPTNKEFHFILDVSVKTVANLELSNIKCVLEDNKCSYFLS 235
KE Q N + H + +LD+ T+ NL S + L N+ S
Sbjct: 254 -PKEIGNCTQITNLDLQH---------NELLDLP-DTIGNLS-SLSRLGLRYNRLSAIPR 301
Query: 236 ILAKLQTNPKLSNLTLNNIETTWNSFIRILQLVWHTTVWYFSISNVKLQGQLDFRDFDYS 295
LAK +L NL NNI T S + L + T+ + G F YS
Sbjct: 302 SLAKCSALEEL-NLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTI-YS 359
Query: 296 GTSLKALSIHQVVSDVFGFPQSYIYEIFSNMNIKNFTVSGTRMVHMLCPSKISPFLHLDF 355
+++ I+++ +F ++ S +N+K+ ++ + S + L+
Sbjct: 360 -LNMEHNRINKIPFGIFSRA-----KVLSKLNMKDNQLTSLPLDFGTWTSMV----ELNL 409
Query: 356 SNNLLTDTVFENCGHLTELETLILQMNQLKELSKIAEMTTQMKSLQQLDISQNSVSYDEK 415
+ N LT + E+ L LE LIL N LK K+ ++ L++LD+ +N + +
Sbjct: 410 ATNQLT-KIPEDVSGLVSLEVLILSNNLLK---KLPHGLGNLRKLRELDLEENKL--ESL 463
Query: 416 KGDCSWTKSLLSLNMSSNILTDTIFRCLP--PRIKVLDLHSNKIKSIPKQVVKLEALQEL 473
+ ++ K L L +++N LT T+ R + + L L N + +P+++ LE L+EL
Sbjct: 464 PNEIAYLKDLQKLVLTNNQLT-TLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEEL 522
Query: 474 NVAFN-SLTDLP-GCGSFSSLSVLIIDHNSVSH 504
+ N +L LP S LS++ I++ +SH
Sbjct: 523 YLNDNPNLHSLPFELALCSKLSIMSIENCPLSH 555
Score = 53.9 bits (128), Expect = 6e-07
Identities = 51/189 (26%), Positives = 91/189 (48%), Gaps = 18/189 (9%)
Query: 344 PSKISPFLHLDFSNNLLTDTVFENCGHLTELETLILQMNQLKELSKIAEMTTQMKSLQQL 403
PS+ S L+ +N + F L L ++ NQL L T S+ +L
Sbjct: 351 PSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWT---SMVEL 407
Query: 404 DISQNSVSYDEKKGDCSWTKSLLSLNMSSNILTDTIFRCLPP------RIKVLDLHSNKI 457
+++ N ++ + D S SL L +S+N+L + LP +++ LDL NK+
Sbjct: 408 NLATNQLTKIPE--DVSGLVSLEVLILSNNLL-----KKLPHGLGNLRKLRELDLEENKL 460
Query: 458 KSIPKQVVKLEALQELNVAFNSLTDLP-GCGSFSSLSVLIIDHNSVSHPSADFFQSCQKM 516
+S+P ++ L+ LQ+L + N LT LP G G ++L+ L + N ++H + + + +
Sbjct: 461 ESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEE-IGTLENL 519
Query: 517 RSIKAGDNP 525
+ DNP
Sbjct: 520 EELYLNDNP 528
Score = 49.3 bits (116), Expect = 1e-05
Identities = 47/196 (23%), Positives = 91/196 (46%), Gaps = 46/196 (23%)
Query: 363 TVFENCGHLTELETLILQMNQLKEL-SKIAEMTTQMKSLQQLDISQNSVSYDEKK-GDCS 420
TV ++ +L++L L ++ N++K+L ++I E+ +L LD++ N + + K+ G+C+
Sbjct: 206 TVEKDIKNLSKLSMLSIRENKIKQLPAEIGELC----NLITLDVAHNQLEHLPKEIGNCT 261
Query: 421 WTKSLLSLNMSSNILTDTIFRCLPPRI------KVLDLHSNKIKSIPKQVVKLEALQELN 474
+ +L++ N L D LP I L L N++ +IP+ + K AL+ELN
Sbjct: 262 ---QITNLDLQHNELLD-----LPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELN 313
Query: 475 VAFNSLTDLP--------------------------GCGSFSSLSVLIIDHNSVSHPSAD 508
+ N+++ LP G FS++ L ++HN ++
Sbjct: 314 LENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFG 373
Query: 509 FFQSCQKMRSIKAGDN 524
F + + + DN
Sbjct: 374 IFSRAKVLSKLNMKDN 389
Score = 48.9 bits (115), Expect = 2e-05
Identities = 44/176 (25%), Positives = 80/176 (45%), Gaps = 26/176 (14%)
Query: 382 NQLKELSKIAEMTTQMKSLQQLDISQNSVSYDEKKGDCSWTKSLLSLNMSSNILTDTIFR 441
+ +KEL+++ E+ LQ L + +L++L +S N LT
Sbjct: 117 SSIKELTQLTELYLYSNKLQSLP------------AEVGCLVNLMTLALSENSLTS---- 160
Query: 442 CLPP------RIKVLDLHSNKIKSIPKQVVKLEALQELNVAFNSLTDL-PGCGSFSSLSV 494
LP ++++LDL NK++ IP V +L++L L + FN +T + + S LS+
Sbjct: 161 -LPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSM 219
Query: 495 LIIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQCTCELGEF--VKNIDQVSSEVLE 548
L I N + A+ + C + A + E+G + N+D +E+L+
Sbjct: 220 LSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLD 275
Score = 32.3 bits (72), Expect = 1.7
Identities = 26/105 (24%), Positives = 45/105 (42%), Gaps = 5/105 (4%)
Query: 441 RCLPPRIKVLDLHSNKIKSIPKQVVKLEALQELNVAFNSLTDLPG-CGSFSSLSVLIIDH 499
+C LDL I +P + +L L EL + N L LP G +L L +
Sbjct: 96 KCREENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSE 155
Query: 500 NSVSHPSADFFQSCQKMRSIKAGDNPFQCTCELGEFVKNIDQVSS 544
NS++ D + +K+R + N + E+ V +D +++
Sbjct: 156 NSLT-SLPDSLDNLKKLRMLDLRHNKLR---EIPSVVYRLDSLTT 196
>gi|19923729 leucine rich repeat containing 8 family, member C [Homo
sapiens]
Length = 803
Score = 54.3 bits (129), Expect = 4e-07
Identities = 58/212 (27%), Positives = 99/212 (46%), Gaps = 17/212 (8%)
Query: 299 LKALSIHQVVSDVFGFPQSYIYEIFSNMNIKNFTVSGTRMVHMLCPSKISPFLHLDFSN- 357
LK+L I + S+V PQ+ + ++ S++ GT++V + K++ L+ +
Sbjct: 541 LKSLKILSIKSNVSKIPQAVV-DVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHC 599
Query: 358 --NLLTDTVFENCGHLTELETLILQMNQLKELSKIAEMTTQMKSLQQLDISQNSVSYDEK 415
+ VF L L+ L L+ N LK + +I ++ L L + NS++Y +
Sbjct: 600 DLERIPHAVFS----LLSLQELDLKENNLKSIEEIVSFQ-HLRKLTVLKLWHNSITYIPE 654
Query: 416 KGDCSWTKSLLSLNMSSN---ILTDTIFRCLPPRIKVLDLHSNKIKSIPKQVVKLEALQE 472
SL L+ S N +L +F C +I+ LDL N I+ IP ++ L++LQ
Sbjct: 655 H--IKKLTSLERLSFSHNKIEVLPSHLFLC--NKIRYLDLSYNDIRFIPPEIGVLQSLQY 710
Query: 473 LNVAFNSLTDLPGCGSF-SSLSVLIIDHNSVS 503
++ N + LP F L L I NS+S
Sbjct: 711 FSITCNKVESLPDELYFCKKLKTLKIGKNSLS 742
Score = 42.4 bits (98), Expect = 0.002
Identities = 31/108 (28%), Positives = 56/108 (51%), Gaps = 10/108 (9%)
Query: 50 LNISQNYISELWTSDILS---LSKLRILIISHNRIQYLDISVFKFNQELEYLDLSHNKLV 106
L++ +N + + +I+S L KL +L + HN I Y+ + K LE L SHNK+
Sbjct: 617 LDLKENNLKSI--EEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTS-LERLSFSHNKIE 673
Query: 107 KISCHPTV--NLKHLDLSFNAFDALPICKEFGNMSQLKFLGLSTTHLE 152
+ H + +++LDLS+N +P E G + L++ ++ +E
Sbjct: 674 VLPSHLFLCNKIRYLDLSYNDIRFIP--PEIGVLQSLQYFSITCNKVE 719
Score = 32.3 bits (72), Expect = 1.7
Identities = 46/171 (26%), Positives = 67/171 (39%), Gaps = 50/171 (29%)
Query: 360 LTDTVFENCGHLTELETLILQMNQLKELSKIAEMTTQMKSLQQLDISQNSVSYDEKKGDC 419
L DTVFE +TEL++L L++ +K + I Q+ +LQ+L + Q SV
Sbjct: 436 LPDTVFE----ITELQSLKLEI--IKNVM-IPATIAQLDNLQELSLHQCSVK-------- 480
Query: 420 SWTKSLLSLNMSSNILTDTIFRCLPPRIKVLDLHSNKIKSIPKQVVKLEALQEL------ 473
+ L +KVL + + ++ +P + L L+EL
Sbjct: 481 ---------------IHSAALSFLKENLKVLSVKFDDMRELPPWMYGLRNLEELYLVGSL 525
Query: 474 ------NVAFNSLTDLPGCGSFSSLSVLIIDHNSVSHPSA--DFFQSCQKM 516
NV SL DL SL +L I N P A D QKM
Sbjct: 526 SHDISRNVTLESLRDL------KSLKILSIKSNVSKIPQAVVDVSSHLQKM 570
>gi|110825984 malignant fibrous histiocytoma amplified sequence 1
[Homo sapiens]
Length = 1052
Score = 54.3 bits (129), Expect = 4e-07
Identities = 53/178 (29%), Positives = 87/178 (48%), Gaps = 10/178 (5%)
Query: 353 LDFSNNLLTDTVFENCGHLTELETLILQMNQLKELSKIAEMTTQMKSLQQLDISQNSVSY 412
LD S+N LT E L EL L L NQL L + L++LD+S N +++
Sbjct: 116 LDVSHNRLTALGAEVVSALRELRKLNLSHNQLPAL---PAQLGALAHLEELDVSFNRLAH 172
Query: 413 DEKKGDCSWTKSLLSLNMSSNILTDTIFRCLP-PRIKVLDLHSNKIKSIPKQVVKLEALQ 471
C L +L++ N LT + L ++ LD+ SN+++ +P+ + L AL+
Sbjct: 173 LPDSLSC--LSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALK 230
Query: 472 ELNVAFNSLTDLP-GCGSFSSLSVLIIDHNSVSHPSADFFQSC-QKMRSIKAGDNPFQ 527
L ++ L LP G +SL L++D+N + A F SC Q+++ + N F+
Sbjct: 231 ILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQF--SCLQRLKMLNLSSNLFE 286
Score = 45.8 bits (107), Expect = 2e-04
Identities = 32/105 (30%), Positives = 51/105 (48%), Gaps = 5/105 (4%)
Query: 50 LNISQNYISELWTSDILSLSKLRILIISHNRIQYLDISVFKFNQELEYLDLSHNKLVKIS 109
LN+ N + E+ +L LR+L++ NR L +V + L LD+SHN+L +
Sbjct: 68 LNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLTALG 127
Query: 110 CHPTV---NLKHLDLSFNAFDALPICKEFGNMSQLKFLGLSTTHL 151
L+ L+LS N ALP + G ++ L+ L +S L
Sbjct: 128 AEVVSALRELRKLNLSHNQLPALP--AQLGALAHLEELDVSFNRL 170
Score = 42.7 bits (99), Expect = 0.001
Identities = 52/182 (28%), Positives = 85/182 (46%), Gaps = 11/182 (6%)
Query: 327 NIKNFTVSGTRMVHMLCP-SKISPFLHLDFSNNLLTDTVFENCGHLTELETLILQMNQLK 385
+++ VS R+ H+ S +S LD +N LT L LE L + N+L+
Sbjct: 159 HLEELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLT-AFPRQLLQLVALEELDVSSNRLR 217
Query: 386 ELSKIAEMTTQMKSLQQLDISQNSVSYDEKKGDCSWTKSLLSLNMSSNILT--DTIFRCL 443
L E + +++L+ L +S + G C SL SL + +N L F CL
Sbjct: 218 GLP---EDISALRALKILWLSGAELG-TLPAGFCELA-SLESLMLDNNGLQALPAQFSCL 272
Query: 444 PPRIKVLDLHSNKIKSIPKQVVKLEALQELNVAFNSLTDLPG-CGSFSSLSVLIIDHNSV 502
R+K+L+L SN + P ++ L L+EL ++ N LT +P L L +D+N +
Sbjct: 273 Q-RLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRI 331
Query: 503 SH 504
+
Sbjct: 332 RY 333
Score = 37.0 bits (84), Expect = 0.071
Identities = 41/148 (27%), Positives = 70/148 (47%), Gaps = 12/148 (8%)
Query: 371 LTELETLILQMNQLKELSKIAEMTTQMKSLQQLDISQNSVSYDEKKGDCSWTKSLLSLNM 430
L LE+L+L N L+ L + ++ L+ L++S N ++E L L +
Sbjct: 249 LASLESLMLDNNGLQALPA---QFSCLQRLKMLNLSSNL--FEEFPAALLPLAGLEELYL 303
Query: 431 SSNILTD--TIFRCLPPRIKVLDLHSNKIKSIPKQVVKLEALQELNVAFNSLTDLPG-CG 487
S N LT ++ L R+ L L +N+I+ +P +V+L L+EL + N + LP G
Sbjct: 304 SRNQLTSVPSLISGLG-RLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDHFG 362
Query: 488 SFSSLSVLIIDHNSVSHPSADFFQSCQK 515
S + + I N + P ++ C K
Sbjct: 363 QLSRVGLWKIKDNPLIQPP---YEVCMK 387
>gi|188528675 slit homolog 1 [Homo sapiens]
Length = 1534
Score = 54.3 bits (129), Expect = 4e-07
Identities = 40/126 (31%), Positives = 63/126 (50%), Gaps = 4/126 (3%)
Query: 29 VDRSKNGLIHVPKDLSQKTTILNISQNYISELWTSDILSLSKLRILIISHNRIQYLDISV 88
VD GL +PK++ + T L ++ N I+ + +D L +LR+L + N+I ++
Sbjct: 45 VDCHGTGLQAIPKNIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGA 104
Query: 89 FKFNQELEYLDLSHNK---LVKISCHPTVNLKHLDLSFNAFDALPICKEFGNMSQLKFLG 145
F +ELE L L+ N+ L ++ L LDLS NA A+P K F + LK L
Sbjct: 105 FDDMKELERLRLNRNQLHMLPELLFQNNQALSRLDLSENAIQAIP-RKAFRGATDLKNLQ 163
Query: 146 LSTTHL 151
L +
Sbjct: 164 LDKNQI 169
Score = 51.6 bits (122), Expect = 3e-06
Identities = 53/219 (24%), Positives = 101/219 (46%), Gaps = 21/219 (9%)
Query: 368 CGHLTELETLILQMNQLKELSKIAEMTTQMKSLQQLDISQNSVSYDEKKGDCSWTKSLLS 427
C H E +++ + LK L+KI E Q S +L ++ N +S E G L
Sbjct: 513 CPHKCRCEANVVECSSLK-LTKIPERIPQ--STAELRLNNNEISILEATGMFKKLTHLKK 569
Query: 428 LNMSSNILTDTIFRCLPPRIKVLDLH--SNKIKSIPKQVVK-LEALQELNVAFNSLTDLP 484
+N+S+N +++ V +LH +N+++SI + + L+ L+ L + N ++ +
Sbjct: 570 INLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIH 629
Query: 485 GCGSFSSLS---VLIIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQCTCE---LGEFVKN 538
SF+ L +L + N ++ S F + Q + ++ NPF C C+ LG +++
Sbjct: 630 N-DSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWLGGWLR- 687
Query: 539 IDQVSSEVLEGWPDSYKCDYPESYRGTLLKDFHMSELSC 577
+++ G P +C P+ R L+D + C
Sbjct: 688 ----KRKIVTGNP---RCQNPDFLRQIPLQDVAFPDFRC 719
Score = 44.3 bits (103), Expect = 4e-04
Identities = 46/189 (24%), Positives = 87/189 (46%), Gaps = 15/189 (7%)
Query: 397 MKSLQQLDISQNSVSYDEKKGDCSWTKSLLSLNMSSN---ILTDTIFRCLPPRIKVLDLH 453
+K L+ L + +N + E+ G K L L ++ N +L + +F+ + LDL
Sbjct: 84 LKQLRVLQLMENQIGAVER-GAFDDMKELERLRLNRNQLHMLPELLFQN-NQALSRLDLS 141
Query: 454 SNKIKSIPKQVVK-LEALQELNVAFNSLTDLPGCGSFSSL---SVLIIDHNSVSHPSADF 509
N I++IP++ + L+ L + N ++ + G+F +L VL +++N+++
Sbjct: 142 ENAIQAIPRKAFRGATDLKNLQLDKNQISCIEE-GAFRALRGLEVLTLNNNNITTIPVSS 200
Query: 510 FQSCQKMRSIKAGDNPFQCTCELGEFVKNIDQVSSEVLEGWPDSYKCDYPESYRGTLLKD 569
F K+R+ + N C C L + + Q + L +C P S RG + +
Sbjct: 201 FNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGL-----FTQCSGPASLRGLNVAE 255
Query: 570 FHMSELSCN 578
SE SC+
Sbjct: 256 VQKSEFSCS 264
Score = 41.6 bits (96), Expect = 0.003
Identities = 34/136 (25%), Positives = 56/136 (41%), Gaps = 12/136 (8%)
Query: 447 IKVLDLHSNKIKSIPKQ-VVKLEALQELNVAFNSLTDLPGCG--SFSSLSVLIIDHNSVS 503
++++DL +NKI S+ + L L +++N+L +P SL +L + N +S
Sbjct: 786 LQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDIS 845
Query: 504 HPSADFFQSCQKMRSIKAGDNPFQCTCELGEFVKNIDQVSSEVLEGW--PDSYKCDYPES 561
F + + G NP C C L +SS V G+ P +C P+
Sbjct: 846 TLQEGIFADVTSLSHLAIGANPLYCDCHL-------RWLSSWVKTGYKEPGIARCAGPQD 898
Query: 562 YRGTLLKDFHMSELSC 577
G LL + C
Sbjct: 899 MEGKLLLTTPAKKFEC 914
Score = 36.2 bits (82), Expect = 0.12
Identities = 31/114 (27%), Positives = 50/114 (43%), Gaps = 27/114 (23%)
Query: 446 RIKVLDLHSNKIKSI-PKQVVKLEALQELNVAFNSLTDLPG--CGSFSSLSVLIIDHNSV 502
+++ +DL +N+I I P L +L L + N +TDLP G +L +L+++ N +
Sbjct: 334 KLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKI 393
Query: 503 SHPSADFFQSCQ----------KMRSIKAG--------------DNPFQCTCEL 532
+ D FQ Q K++S+ G NPF C C L
Sbjct: 394 NCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNL 447
Score = 32.7 bits (73), Expect = 1.3
Identities = 24/88 (27%), Positives = 45/88 (51%), Gaps = 7/88 (7%)
Query: 327 NIKNFTVSGTRMVHMLCPSKISPFLHL---DFSNNLLTDTVFENCGHLTELETLILQMNQ 383
N+ + G + L P ++S F +L D SNN ++ + ++++L TLIL N
Sbjct: 762 NVTELYLDGNQFT--LVPGQLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNA 819
Query: 384 LKELSKIAEMTTQMKSLQQLDISQNSVS 411
L+ + +A ++SL+ L + N +S
Sbjct: 820 LQCIPPLA--FQGLRSLRLLSLHGNDIS 845
Score = 31.6 bits (70), Expect = 3.0
Identities = 21/82 (25%), Positives = 43/82 (52%), Gaps = 1/82 (1%)
Query: 28 LVDRSKNGLIHVPKDLSQKTTILNISQNYISELWTSDILS-LSKLRILIISHNRIQYLDI 86
+V+ S L +P+ + Q T L ++ N IS L + + L+ L+ + +S+N++ ++
Sbjct: 523 VVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLKKINLSNNKVSEIED 582
Query: 87 SVFKFNQELEYLDLSHNKLVKI 108
F+ + L L+ N+L I
Sbjct: 583 GAFEGAASVSELHLTANQLESI 604
Score = 31.2 bits (69), Expect = 3.9
Identities = 22/84 (26%), Positives = 38/84 (45%)
Query: 25 SEFLVDRSKNGLIHVPKDLSQKTTILNISQNYISELWTSDILSLSKLRILIISHNRIQYL 84
S +VD GL +P +L + T + + N I + KLR + +S+N+I +
Sbjct: 289 SNGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEI 348
Query: 85 DISVFKFNQELEYLDLSHNKLVKI 108
F+ + L L L NK+ +
Sbjct: 349 APDAFQGLRSLNSLVLYGNKITDL 372
Score = 30.0 bits (66), Expect = 8.7
Identities = 34/139 (24%), Positives = 60/139 (43%), Gaps = 29/139 (20%)
Query: 344 PSKISPFLHL---DFSNNLLTDTVFENCGHLTELETLILQMNQLKELSKIAEMTTQMKSL 400
P SP+ L D SNN + + + L L +L+L N++ +L + + + +L
Sbjct: 326 PGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPR--GVFGGLYTL 383
Query: 401 QQLDISQNSVSYDEKKGDCSWTKSLLSLNMSSNILTDTIFRCLPPRIKVLDLHSNKIKSI 460
Q L ++ N + N + F+ L + +L L+ NKI+S+
Sbjct: 384 QLLLLNANKI----------------------NCIRPDAFQDL-QNLSLLSLYDNKIQSL 420
Query: 461 PK-QVVKLEALQELNVAFN 478
K L A+Q L++A N
Sbjct: 421 AKGTFTSLRAIQTLHLAQN 439
Score = 30.0 bits (66), Expect = 8.7
Identities = 22/84 (26%), Positives = 39/84 (46%), Gaps = 3/84 (3%)
Query: 29 VDRSKNGLIHVPKDLSQKTTILN---ISQNYISELWTSDILSLSKLRILIISHNRIQYLD 85
+D S N + + D Q LN + N I++L L L++L+++ N+I +
Sbjct: 338 IDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIR 397
Query: 86 ISVFKFNQELEYLDLSHNKLVKIS 109
F+ Q L L L NK+ ++
Sbjct: 398 PDAFQDLQNLSLLSLYDNKIQSLA 421
Score = 30.0 bits (66), Expect = 8.7
Identities = 21/64 (32%), Positives = 33/64 (51%), Gaps = 7/64 (10%)
Query: 86 ISVFKFNQELEYLDLSHNKLVKISCHPTVNLKHLD---LSFNAFDALPICKEFGNMSQLK 142
+S FK+ L+ +DLS+NK+ +S N+ L LS+NA +P F + L+
Sbjct: 780 LSTFKY---LQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPL-AFQGLRSLR 835
Query: 143 FLGL 146
L L
Sbjct: 836 LLSL 839
>gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]
Length = 1302
Score = 53.9 bits (128), Expect = 6e-07
Identities = 50/165 (30%), Positives = 78/165 (47%), Gaps = 9/165 (5%)
Query: 344 PSKISPFLHLD--FSNNLLTDTVFENCGHLTELETLILQMNQLKELSKIAEMTTQMKSLQ 401
P S L+L + N+ + + N G LT+L+ L L+ NQLK L K TQ L+
Sbjct: 131 PDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQ---LE 187
Query: 402 QLDISQNSVSYDEKKGDCSWTKSLLSLNMSSNILTDTI-FRCLPPRIKVLDLHSNKIKSI 460
+LD+ N + E L M +N LT F ++ LD+ N I+ +
Sbjct: 188 RLDLGSN--EFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMV 245
Query: 461 PKQVVKLEALQELNVAFNSLTDLP-GCGSFSSLSVLIIDHNSVSH 504
+ + E LQ+L ++ NSL LP GS +++ L ID N + +
Sbjct: 246 EEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMY 290
Score = 48.5 bits (114), Expect = 2e-05
Identities = 46/166 (27%), Positives = 81/166 (48%), Gaps = 28/166 (16%)
Query: 352 HLDFSNNLLTDTVFENCGHLTELETLILQMNQLKELSKIAEMTTQMKSLQQLDISQNSVS 411
+LD S N + + V E L+ L+L N L++L E +K++ L I +N +
Sbjct: 234 YLDVSKNNI-EMVEEGISTCENLQDLLLSSNSLQQLP---ETIGSLKNITTLKIDENQLM 289
Query: 412 Y---------DEKKGDCSWTKSLL---SLNMSSNILT----DTIFRCLPPRI------KV 449
Y ++ DCS+ + S+ +N+ T + LPP I V
Sbjct: 290 YLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITV 349
Query: 450 LDLHSNKIKSIPKQVVKLEALQELNVAFNSLTDLPGCGSFSSLSVL 495
L LHSNK++++P+++ ++ L+ +N++ N L +LP SF+ L L
Sbjct: 350 LFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLP--FSFTKLQQL 393
Score = 43.9 bits (102), Expect = 6e-04
Identities = 57/269 (21%), Positives = 104/269 (38%), Gaps = 69/269 (25%)
Query: 353 LDFSNNLLTDTVFENCGHLTELETLILQMNQLKELSKIA--------------EMTT--- 395
LD+S+ L E LE L L NQ++EL K ++TT
Sbjct: 27 LDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPA 86
Query: 396 ---QMKSLQQLDISQNSV-SYDEKKGDCSWTKSLLS---------------LNMSSNILT 436
+ +L++LD+S+N + + E +C + + LN++ L
Sbjct: 87 SIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLN 146
Query: 437 DTIFRCLP------PRIKVLDLHSNKIKSIPKQVVKLEALQELNVAFNSLTDLPG----- 485
D LP ++++L+L N++K +PK + +L L+ L++ N T++P
Sbjct: 147 DAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQL 206
Query: 486 -------------------CGSFSSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGDNPF 526
GS L+ L + N++ + +C+ ++ + N
Sbjct: 207 SGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVE-EGISTCENLQDLLLSSNSL 265
Query: 527 QCTCELGEFVKNID--QVSSEVLEGWPDS 553
Q E +KNI ++ L PDS
Sbjct: 266 QQLPETIGSLKNITTLKIDENQLMYLPDS 294
Score = 42.0 bits (97), Expect = 0.002
Identities = 38/147 (25%), Positives = 74/147 (50%), Gaps = 10/147 (6%)
Query: 11 FMLILQIRIQLSEESEFLVDRSKNGLIHVPKDLS--QKTTILNISQNYISELWTSDILSL 68
F + ++ QLS EF +D N L +P + ++ T L++S+N I E+ I +
Sbjct: 196 FTEVPEVLEQLSGLKEFWMDA--NRLTFIPGFIGSLKQLTYLDVSKNNI-EMVEEGISTC 252
Query: 69 SKLRILIISHNRIQYLDISVFKFNQELEYLDLSHNKLVKI--SCHPTVNLKHLDLSFNAF 126
L+ L++S N +Q L ++ + + L + N+L+ + S ++++ LD SFN
Sbjct: 253 ENLQDLLLSSNSLQQLPETIGSL-KNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEV 311
Query: 127 DALPICKEFGNMSQLKFLGLSTTHLEK 153
+ALP G ++ L+ +L++
Sbjct: 312 EALP--SSIGQLTNLRTFAADHNYLQQ 336
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.135 0.402
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,412,484
Number of Sequences: 37866
Number of extensions: 1169131
Number of successful extensions: 4650
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 185
Number of HSP's successfully gapped in prelim test: 90
Number of HSP's that attempted gapping in prelim test: 3089
Number of HSP's gapped (non-prelim): 1114
length of query: 786
length of database: 18,247,518
effective HSP length: 110
effective length of query: 676
effective length of database: 14,082,258
effective search space: 9519606408
effective search space used: 9519606408
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.