Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 41350198
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|41350198 fetal globin inducing factor [Homo sapiens]
(239 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|41350198 fetal globin inducing factor [Homo sapiens] 492 e-139
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 88 7e-18
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 85 6e-17
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 81 7e-16
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 81 7e-16
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 81 7e-16
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 81 7e-16
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 81 7e-16
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 79 3e-15
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 78 6e-15
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 78 8e-15
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 77 1e-14
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 76 3e-14
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 76 3e-14
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 76 3e-14
gi|224465233 euchromatic histone-lysine N-methyltransferase 1 is... 74 9e-14
gi|16975496 cortactin binding protein 2 [Homo sapiens] 73 2e-13
gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens] 72 6e-13
gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens] 72 6e-13
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 71 7e-13
gi|56676397 ankyrin repeat domain 11 [Homo sapiens] 71 9e-13
gi|156142199 euchromatic histone-lysine N-methyltransferase 2 is... 70 2e-12
gi|156142197 euchromatic histone-lysine N-methyltransferase 2 is... 70 2e-12
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 69 4e-12
gi|103471993 huntingtin interacting protein 14 [Homo sapiens] 69 5e-12
gi|62420875 integrin-linked kinase [Homo sapiens] 68 6e-12
gi|62420873 integrin-linked kinase [Homo sapiens] 68 6e-12
gi|4758606 integrin-linked kinase [Homo sapiens] 68 6e-12
gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo ... 67 1e-11
gi|55742857 ankyrin repeat domain 6 [Homo sapiens] 67 1e-11
>gi|41350198 fetal globin inducing factor [Homo sapiens]
Length = 239
Score = 492 bits (1267), Expect = e-139
Identities = 239/239 (100%), Positives = 239/239 (100%)
Query: 1 MEKEKGNDDGIPDQENSLDFSEHFNQLELLETHGHLIPTGTQSLWVGNSDEDEEQDDKNE 60
MEKEKGNDDGIPDQENSLDFSEHFNQLELLETHGHLIPTGTQSLWVGNSDEDEEQDDKNE
Sbjct: 1 MEKEKGNDDGIPDQENSLDFSEHFNQLELLETHGHLIPTGTQSLWVGNSDEDEEQDDKNE 60
Query: 61 EWYRLQEKKMEKDPSRLLLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGH 120
EWYRLQEKKMEKDPSRLLLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGH
Sbjct: 61 EWYRLQEKKMEKDPSRLLLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGH 120
Query: 121 LDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHL 180
LDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHL
Sbjct: 121 LDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHL 180
Query: 181 AAGNRDSKDTLELLLMNRYVKPGLKNNLEETAFDIARRTSIYHYLFEIVEGCTNSSPQS 239
AAGNRDSKDTLELLLMNRYVKPGLKNNLEETAFDIARRTSIYHYLFEIVEGCTNSSPQS
Sbjct: 181 AAGNRDSKDTLELLLMNRYVKPGLKNNLEETAFDIARRTSIYHYLFEIVEGCTNSSPQS 239
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 87.8 bits (216), Expect = 7e-18
Identities = 55/138 (39%), Positives = 76/138 (55%), Gaps = 3/138 (2%)
Query: 81 AAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVD 140
AA++ + V LL A +VN ++ TPLH AA +++ + L+ QGA V A T
Sbjct: 671 AAQEGHVDMVSLLLGRNA-NVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKM 729
Query: 141 GWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNRYV 200
G+TPLH C + N ++ +FLLQH A +NA+TK TPLH AA + + +LL N
Sbjct: 730 GYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAA-QQGHTHIINVLLQNNAS 788
Query: 201 KPGLKNNLEETAFDIARR 218
L N TA IARR
Sbjct: 789 PNELTVN-GNTALGIARR 805
Score = 80.9 bits (198), Expect = 9e-16
Identities = 44/102 (43%), Positives = 62/102 (60%), Gaps = 1/102 (0%)
Query: 81 AAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVD 140
AA + VR L+ + A V + +D+ TPLH +A G DIVQ+L+ QGA +A T
Sbjct: 473 AARSGQAEVVRYLVQDGA-QVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTS 531
Query: 141 GWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAA 182
G+TPLH + + + VA+FLL H A ++ TK TPLH+AA
Sbjct: 532 GYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAA 573
Score = 75.5 bits (184), Expect = 4e-14
Identities = 50/137 (36%), Positives = 71/137 (51%), Gaps = 3/137 (2%)
Query: 66 QEKKMEKDPSRLLLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQ 125
Q + KD L +A + V++LL + A+ N YTPLH +A GH D+
Sbjct: 491 QVEAKAKDDQTPLHISARLGKADIVQQLLQQGASP-NAATTSGYTPLHLSAREGHEDVAA 549
Query: 126 ELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNR 185
L+ GA + T G+TPLH A K+ VA+ LLQ A +A K LTPLH+AA
Sbjct: 550 FLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYD 609
Query: 186 DSKDTLELLLMNRYVKP 202
+ K + LLL+++ P
Sbjct: 610 NQK--VALLLLDQGASP 624
Score = 74.3 bits (181), Expect = 9e-14
Identities = 49/139 (35%), Positives = 72/139 (51%), Gaps = 3/139 (2%)
Query: 81 AAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVD 140
A + + L V+ LL V+ D T LH AA+ GH + + L+ + A+ +A ++
Sbjct: 341 ATQGDHLNCVQLLLQHNVP-VDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALN 399
Query: 141 GWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNRYV 200
G+TPLH ACK N +V LL+H A I A T+ LTP+H+AA + LM+
Sbjct: 400 GFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFM--GHVNIVSQLMHHGA 457
Query: 201 KPGLKNNLEETAFDIARRT 219
P N ETA +A R+
Sbjct: 458 SPNTTNVRGETALHMAARS 476
Score = 68.9 bits (167), Expect = 4e-12
Identities = 46/138 (33%), Positives = 68/138 (49%), Gaps = 2/138 (1%)
Query: 79 LWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVT 138
L A K V LL +K+ + + TPLH AA+ + + L+ QGA HA
Sbjct: 569 LHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAA 628
Query: 139 VDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNR 198
+G+TPLH A K N +A+ LL++ AD NA T+ + +HLAA ++ + LL+ R
Sbjct: 629 KNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAA--QEGHVDMVSLLLGR 686
Query: 199 YVKPGLKNNLEETAFDIA 216
L N T +A
Sbjct: 687 NANVNLSNKSGLTPLHLA 704
Score = 68.6 bits (166), Expect = 5e-12
Identities = 37/102 (36%), Positives = 56/102 (54%), Gaps = 1/102 (0%)
Query: 81 AAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVD 140
A +KNR+ + LL A+ + E TP+H AA+ GH++IV +L+ GA + V
Sbjct: 407 ACKKNRIKVMELLLKHGAS-IQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVR 465
Query: 141 GWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAA 182
G T LH A + V +L+Q A + A+ K TPLH++A
Sbjct: 466 GETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISA 507
Score = 65.9 bits (159), Expect = 3e-11
Identities = 42/146 (28%), Positives = 75/146 (51%), Gaps = 2/146 (1%)
Query: 52 DEEQDDKNEEWYRLQEKKMEKDPSRLLLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTP 111
+EE + K + R +++K + D + L AA L + + +N +++
Sbjct: 19 EEEPEKKRKHRKRSRDRKKKSDANASYLRAARAGHLEKALDYI-KNGVDINICNQNGLNA 77
Query: 112 LHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQT 171
LH A+ GH+++V EL+ + A+V A T G T LH A V L+ + A++NAQ+
Sbjct: 78 LHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQS 137
Query: 172 KGLLTPLHLAAGNRDSKDTLELLLMN 197
+ TPL++AA + + ++ LL N
Sbjct: 138 QNGFTPLYMAA-QENHLEVVKFLLDN 162
Score = 65.5 bits (158), Expect = 4e-11
Identities = 44/133 (33%), Positives = 70/133 (52%), Gaps = 2/133 (1%)
Query: 90 VRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSAC 149
V LL +A V+ ++ TPLH A+ G+ ++V+ L+ +GA + A T DG TPLH
Sbjct: 250 VATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGA 309
Query: 150 KWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNRYVKPGLKNNLE 209
+ + +V LL A I ++TK L+PLH+A D + ++LLL + + N+
Sbjct: 310 RSGHEQVVEMLLDRAAPILSKTKNGLSPLHMAT-QGDHLNCVQLLLQHNVPVDDVTNDY- 367
Query: 210 ETAFDIARRTSIY 222
TA +A Y
Sbjct: 368 LTALHVAAHCGHY 380
Score = 65.5 bits (158), Expect = 4e-11
Identities = 39/106 (36%), Positives = 57/106 (53%), Gaps = 1/106 (0%)
Query: 90 VRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSAC 149
V LL ++ + ++ YTPLH AA +DI L+ GAD +AVT G +H A
Sbjct: 613 VALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAA 672
Query: 150 KWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLL 195
+ + + S LL +A++N K LTPLHLAA D + E+L+
Sbjct: 673 QEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAA-QEDRVNVAEVLV 717
Score = 65.1 bits (157), Expect = 5e-11
Identities = 34/104 (32%), Positives = 56/104 (53%)
Query: 79 LWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVT 138
L A K + +LL ++ ++ + D TPLH A SGH +V+ L+ + A + + T
Sbjct: 272 LHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKT 331
Query: 139 VDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAA 182
+G +PLH A + ++ LLQH+ ++ T LT LH+AA
Sbjct: 332 KNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAA 375
Score = 63.9 bits (154), Expect = 1e-10
Identities = 40/116 (34%), Positives = 67/116 (57%), Gaps = 3/116 (2%)
Query: 81 AAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVD 140
AA+++R+ L+++ A HV+ + + YTPLH + G++ IV L+ A V+A T +
Sbjct: 704 AAQEDRVNVAEVLVNQGA-HVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKN 762
Query: 141 GWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLA--AGNRDSKDTLELL 194
G+TPLH A + +T + + LLQ++A N T T L +A G DTL+++
Sbjct: 763 GYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTLKIV 818
Score = 62.4 bits (150), Expect = 3e-10
Identities = 39/108 (36%), Positives = 60/108 (55%), Gaps = 5/108 (4%)
Query: 90 VRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSAC 149
V ++L +VN + ++ +TPL+ AA HL++V+ L+ GA T DG+TPL A
Sbjct: 122 VVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVAL 181
Query: 150 KWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMN 197
+ + +V S LL++D + K L LH+AA D+K LLL N
Sbjct: 182 QQGHDQVVSLLLEND----TKGKVRLPALHIAARKDDTK-AAALLLQN 224
Score = 59.3 bits (142), Expect = 3e-09
Identities = 35/111 (31%), Positives = 57/111 (51%), Gaps = 2/111 (1%)
Query: 88 TTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHS 147
T LL + + + + +TPLH AA+ G++++ L+ + A V + TPLH
Sbjct: 215 TKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHV 274
Query: 148 ACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNR 198
A K N + LL A I+A+T+ LTPLH G R + + +L++R
Sbjct: 275 ASKRGNANMVKLLLDRGAKIDAKTRDGLTPLH--CGARSGHEQVVEMLLDR 323
Score = 58.9 bits (141), Expect = 4e-09
Identities = 38/102 (37%), Positives = 50/102 (49%), Gaps = 1/102 (0%)
Query: 81 AAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVD 140
AA + V +L+ A+ T E T LH AA SG ++V+ L+ GA V A D
Sbjct: 440 AAFMGHVNIVSQLMHHGASPNTTNVRGE-TALHMAARSGQAEVVRYLVQDGAQVEAKAKD 498
Query: 141 GWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAA 182
TPLH + + + LLQ A NA T TPLHL+A
Sbjct: 499 DQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSA 540
Score = 58.2 bits (139), Expect = 6e-09
Identities = 37/117 (31%), Positives = 65/117 (55%), Gaps = 2/117 (1%)
Query: 81 AAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVD 140
A+++ + V LL +A +V+ + T LH A+ +G ++V+ L+ GA+V+A + +
Sbjct: 81 ASKEGHVEVVSELLQREA-NVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQN 139
Query: 141 GWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMN 197
G+TPL+ A + N+ V FLL + A + T+ TPL +A + + LLL N
Sbjct: 140 GFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVAL-QQGHDQVVSLLLEN 195
Score = 57.8 bits (138), Expect = 8e-09
Identities = 33/93 (35%), Positives = 47/93 (50%)
Query: 90 VRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSAC 149
V L + ++ + +TPLH AA G L++ L+ + A A G TPLH A
Sbjct: 547 VAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAA 606
Query: 150 KWNNTRVASFLLQHDADINAQTKGLLTPLHLAA 182
++N +VA LL A +A K TPLH+AA
Sbjct: 607 HYDNQKVALLLLDQGASPHAAAKNGYTPLHIAA 639
Score = 53.9 bits (128), Expect = 1e-07
Identities = 43/123 (34%), Positives = 66/123 (53%), Gaps = 11/123 (8%)
Query: 78 LLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAV 137
L AA++N L V+ LL A+ + ED +TPL A GH D V L+ + V
Sbjct: 144 LYMAAQENHLEVVKFLLDNGASQ-SLATEDGFTPLAVALQQGH-DQVVSLLLENDTKGKV 201
Query: 138 TVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAA--GNRDSKDTLELLL 195
+ LH A + ++T+ A+ LLQ+D + + ++K TPLH+AA GN + + LL
Sbjct: 202 RLPA---LHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNIN----VATLL 254
Query: 196 MNR 198
+NR
Sbjct: 255 LNR 257
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 84.7 bits (208), Expect = 6e-17
Identities = 47/99 (47%), Positives = 62/99 (62%), Gaps = 1/99 (1%)
Query: 90 VRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSAC 149
VR LLS+K ++N D++ TPLH AAY G + I+Q L+ GA+V+A TPLH A
Sbjct: 24 VRSLLSQKE-NINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAA 82
Query: 150 KWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSK 188
N +V LL H AD+NA+ K TPLH+AA NR +K
Sbjct: 83 ASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATK 121
Score = 65.1 bits (157), Expect = 5e-11
Identities = 45/129 (34%), Positives = 64/129 (49%), Gaps = 4/129 (3%)
Query: 69 KMEKDPSRLLLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELI 128
K E+ P L WAA L V +LL + + +D Y LH AA SG +++V+ L+
Sbjct: 171 KKERQP---LHWAAFLGHLE-VLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLL 226
Query: 129 AQGADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSK 188
GA++ G T LH AC VA L+ A++N TPLH+AA + +
Sbjct: 227 RMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGA 286
Query: 189 DTLELLLMN 197
LELL+ N
Sbjct: 287 LCLELLVNN 295
Score = 59.3 bits (142), Expect = 3e-09
Identities = 36/101 (35%), Positives = 56/101 (55%), Gaps = 1/101 (0%)
Query: 81 AAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVD 140
A L TV LL++ A+ +N D+ E PLH AA+ GHL++++ L+A+GAD+
Sbjct: 147 AVHSGHLETVNLLLNKGAS-LNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRK 205
Query: 141 GWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLA 181
G+ LH+A V +LL+ A+I+ T LH+A
Sbjct: 206 GYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIA 246
Score = 50.8 bits (120), Expect = 1e-06
Identities = 30/85 (35%), Positives = 50/85 (58%), Gaps = 1/85 (1%)
Query: 111 PLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQ 170
PL +A +S ++ V+ L++Q +++ + + TPLH+A + + LL A++NA+
Sbjct: 11 PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAK 70
Query: 171 TKGLLTPLHLAAGNRDSKDTLELLL 195
LTPLH AA +R+ K L LLL
Sbjct: 71 DTLWLTPLHRAAASRNEK-VLGLLL 94
Score = 50.8 bits (120), Expect = 1e-06
Identities = 41/127 (32%), Positives = 61/127 (48%), Gaps = 2/127 (1%)
Query: 70 MEKDPSRLLLWAAEKNRLTTVRRLLSEK-ATHVNTRDEDEYTPLHRAAYSGHLDIVQELI 128
+E +P L A N+ +T LL A VN+RD TPLH AA++ ++ ++ L+
Sbjct: 819 LEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLL 878
Query: 129 AQGADVHAVTVDGWTPLHSACKWNNTRVASFLL-QHDADINAQTKGLLTPLHLAAGNRDS 187
A+V+A G T L +A + T FLL + AD+ + T LHLA
Sbjct: 879 QHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHE 938
Query: 188 KDTLELL 194
K L +L
Sbjct: 939 KCALMIL 945
Score = 50.1 bits (118), Expect = 2e-06
Identities = 39/138 (28%), Positives = 57/138 (41%), Gaps = 2/138 (1%)
Query: 79 LWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVT 138
L A NR T L+ + +N D + LH A +SGHL+ V L+ +GA ++
Sbjct: 111 LHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCD 170
Query: 139 VDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNR 198
PLH A + V L+ AD+ + + LH AA + + LL M
Sbjct: 171 KKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGA 230
Query: 199 YVKPGLKNNLEETAFDIA 216
+ N TA IA
Sbjct: 231 EIDE--PNAFGNTALHIA 246
Score = 49.3 bits (116), Expect = 3e-06
Identities = 41/147 (27%), Positives = 61/147 (41%), Gaps = 4/147 (2%)
Query: 78 LLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAV 137
L+ AAE + V LL + DE++ T LH A GH ++A+ D+ +
Sbjct: 895 LMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLI 954
Query: 138 TVDGWT---PLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELL 194
PLH A + V LL H A + A + TP A N+D D L L+
Sbjct: 955 NATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLALI 1014
Query: 195 LMNRYVKPGLKNNLEETAFDIARRTSI 221
L P K+ + +F + + SI
Sbjct: 1015 LSTMKPFPP-KDAVSPFSFSLLKNCSI 1040
Score = 48.5 bits (114), Expect = 5e-06
Identities = 31/90 (34%), Positives = 49/90 (54%), Gaps = 1/90 (1%)
Query: 94 LSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQ-GADVHAVTVDGWTPLHSACKWN 152
L +VN ++ +TPLH AA S + + EL+ GADV+ + +G +PLH A
Sbjct: 258 LVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHG 317
Query: 153 NTRVASFLLQHDADINAQTKGLLTPLHLAA 182
+ L+Q+ ++I+ K TPLH+AA
Sbjct: 318 RFTRSQILIQNGSEIDCADKFGNTPLHVAA 347
Score = 47.8 bits (112), Expect = 9e-06
Identities = 29/89 (32%), Positives = 44/89 (49%)
Query: 93 LLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWN 152
LL VN + ++ +PLH AA G Q LI G+++ G TPLH A ++
Sbjct: 291 LLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYG 350
Query: 153 NTRVASFLLQHDADINAQTKGLLTPLHLA 181
+ + S L+ + AD + + PLHLA
Sbjct: 351 HELLISTLMTNGADTARRGIHDMFPLHLA 379
Score = 45.4 bits (106), Expect = 4e-05
Identities = 35/106 (33%), Positives = 52/106 (49%), Gaps = 1/106 (0%)
Query: 90 VRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSAC 149
+ +LL +VN +D TPLHRAA S + ++ L+A ADV+A TPLH A
Sbjct: 56 ILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAA 115
Query: 150 KWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLL 195
T+ A L + +N + + LH A + +T+ LLL
Sbjct: 116 ANRATKCAEALAPLLSSLNVADRSGRSALHHAV-HSGHLETVNLLL 160
Score = 44.7 bits (104), Expect = 7e-05
Identities = 37/121 (30%), Positives = 55/121 (45%), Gaps = 7/121 (5%)
Query: 65 LQEKKMEKDPSRLLLWAAEKNRLTTVRRLL---SEKATHVNTRDEDEYTPLHRAAYSGHL 121
++E+K + P L AA + T LL E+A + D TPL A +GH+
Sbjct: 646 IKERKRKWTP----LHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHV 701
Query: 122 DIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLA 181
D V L+ +G+ A + G T LH + LL HDA + + TP+HLA
Sbjct: 702 DCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLA 761
Query: 182 A 182
+
Sbjct: 762 S 762
Score = 44.3 bits (103), Expect = 9e-05
Identities = 31/85 (36%), Positives = 45/85 (52%), Gaps = 2/85 (2%)
Query: 101 VNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFL 160
+NT D T LH AA G+++ + L++ GAD+ G TPLH A + + A L
Sbjct: 416 INTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTL 475
Query: 161 LQHDADIN-AQTKGLLTPLHLAAGN 184
+ A +N A KG +PLH AA +
Sbjct: 476 VTAGAGVNEADCKG-CSPLHYAAAS 499
Score = 40.8 bits (94), Expect = 0.001
Identities = 43/150 (28%), Positives = 56/150 (37%), Gaps = 33/150 (22%)
Query: 76 RLLLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVH 135
R L AA LL + RD+ TPLH AA +G L+ GA V+
Sbjct: 424 RTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVN 483
Query: 136 AVTVDGWTPLHSACKWNNTRVA----------------------------SFLLQHDADI 167
G +PLH A + R A FLL + AD
Sbjct: 484 EADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADP 543
Query: 168 NAQTKGLLTPLHLAA--GNRDSKDTLELLL 195
+ + + T +H AA GNR + LELLL
Sbjct: 544 SLRDRQGYTAVHYAAAYGNRQN---LELLL 570
Score = 40.4 bits (93), Expect = 0.001
Identities = 35/107 (32%), Positives = 48/107 (44%), Gaps = 5/107 (4%)
Query: 93 LLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWN 152
LL EK + + D T LHR A +G D + L+ A V G TP+H A
Sbjct: 706 LLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACG 765
Query: 153 NTRVASFLLQHDADINAQTKGL----LTPLHLAAGNRDSKDTLELLL 195
+T V LLQ + G+ +P+H A+ +D LELLL
Sbjct: 766 HTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWAS-YTGHEDCLELLL 811
Score = 39.3 bits (90), Expect = 0.003
Identities = 28/87 (32%), Positives = 43/87 (49%), Gaps = 2/87 (2%)
Query: 110 TPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDAD-IN 168
+PLH AAY+GH + ++ L ++ G T L A + +T L H A +
Sbjct: 587 SPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALI 646
Query: 169 AQTKGLLTPLHLAAGNRDSKDTLELLL 195
+ K TPLH AA + + D+L LL+
Sbjct: 647 KERKRKWTPLHAAAASGHT-DSLHLLI 672
Score = 38.9 bits (89), Expect = 0.004
Identities = 31/104 (29%), Positives = 43/104 (41%)
Query: 79 LWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVT 138
L A +R V LL + VN RD+ TPLH AA + + L + ++
Sbjct: 78 LHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVAD 137
Query: 139 VDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAA 182
G + LH A + + LL A +N K PLH AA
Sbjct: 138 RSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAA 181
Score = 37.4 bits (85), Expect = 0.012
Identities = 27/92 (29%), Positives = 37/92 (40%), Gaps = 18/92 (19%)
Query: 111 PLHRAAYSGHLDIVQELIAQGA------------------DVHAVTVDGWTPLHSACKWN 152
PLH A G D ++L++ G D++ G T LH+A
Sbjct: 375 PLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGG 434
Query: 153 NTRVASFLLQHDADINAQTKGLLTPLHLAAGN 184
N + LL AD+ + K TPLH AA N
Sbjct: 435 NVECLNLLLSSGADLRRRDKFGRTPLHYAAAN 466
Score = 37.4 bits (85), Expect = 0.012
Identities = 33/108 (30%), Positives = 47/108 (43%), Gaps = 3/108 (2%)
Query: 78 LLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQG--ADV- 134
L A E+ V L + A+ + + ++TPLH AA SGH D + LI G AD+
Sbjct: 622 LFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADIT 681
Query: 135 HAVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAA 182
+ G TPL A + LL+ + +A T LH A
Sbjct: 682 DVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGA 729
Score = 33.5 bits (75), Expect = 0.17
Identities = 27/104 (25%), Positives = 48/104 (46%), Gaps = 4/104 (3%)
Query: 102 NTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFLL 161
++ D +E PL + ++ L+ GAD G+T +H A + N + LL
Sbjct: 511 SSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLL 570
Query: 162 QHDADINAQTKGLL--TPLHLAA--GNRDSKDTLELLLMNRYVK 201
+ + + + +PLHLAA G+ ++ TL L+N V+
Sbjct: 571 EMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVR 614
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 81.3 bits (199), Expect = 7e-16
Identities = 49/117 (41%), Positives = 66/117 (56%), Gaps = 2/117 (1%)
Query: 81 AAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVD 140
AA++ V LLS++A N ++ TPLH A GH+ + LI G V A T
Sbjct: 675 AAQEGHAEMVALLLSKQANG-NLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRM 733
Query: 141 GWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMN 197
G+TPLH A + N ++ FLLQH AD+NA+TK +PLH AA + D + LLL N
Sbjct: 734 GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAA-QQGHTDIVTLLLKN 789
Score = 80.5 bits (197), Expect = 1e-15
Identities = 52/150 (34%), Positives = 75/150 (50%), Gaps = 3/150 (2%)
Query: 81 AAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVD 140
A +KN + + LL A+ ++ E TPLH A++ GHL IV+ L+ +GA + V
Sbjct: 411 ACKKNHVRVMELLLKTGAS-IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVK 469
Query: 141 GWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNRYV 200
TPLH A + +T VA +LLQ+ A +NA+ K TPLH AA R + LL+
Sbjct: 470 VETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAA--RIGHTNMVKLLLENNA 527
Query: 201 KPGLKNNLEETAFDIARRTSIYHYLFEIVE 230
P L T IA R + ++E
Sbjct: 528 NPNLATTAGHTPLHIAAREGHVETVLALLE 557
Score = 78.2 bits (191), Expect = 6e-15
Identities = 55/150 (36%), Positives = 79/150 (52%), Gaps = 6/150 (4%)
Query: 81 AAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVD 140
AA+ + L VR LL A ++ D TPLH AA+ GH + + L+ +GA ++ ++
Sbjct: 345 AAQGDHLDCVRLLLQYDA-EIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN 403
Query: 141 GWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNRYV 200
G+TPLH ACK N+ RV LL+ A I+A T+ LTPLH+A+ LL R
Sbjct: 404 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL--QRGA 461
Query: 201 KPGLKNNLEETAFDIARR---TSIYHYLFE 227
P + N ET +A R T + YL +
Sbjct: 462 SPNVSNVKVETPLHMAARAGHTEVAKYLLQ 491
Score = 77.8 bits (190), Expect = 8e-15
Identities = 47/128 (36%), Positives = 68/128 (53%), Gaps = 2/128 (1%)
Query: 79 LWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVT 138
L A K V LL E+ H N ++ TPLH A + +LDIV+ L+ +G H+
Sbjct: 573 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 632
Query: 139 VDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNR 198
+G+TPLH A K N VA LLQ+ NA++ +TPLHLAA ++ + LL+++
Sbjct: 633 WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAA--QEGHAEMVALLLSK 690
Query: 199 YVKPGLKN 206
L N
Sbjct: 691 QANGNLGN 698
Score = 75.1 bits (183), Expect = 5e-14
Identities = 38/91 (41%), Positives = 58/91 (63%)
Query: 92 RLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKW 151
RLL ++ + T+ +DE TPLH AA +GH+ I + L+ GA + A T +G +P+H A +
Sbjct: 289 RLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQG 348
Query: 152 NNTRVASFLLQHDADINAQTKGLLTPLHLAA 182
++ LLQ+DA+I+ T LTPLH+AA
Sbjct: 349 DHLDCVRLLLQYDAEIDDITLDHLTPLHVAA 379
Score = 74.7 bits (182), Expect = 7e-14
Identities = 44/108 (40%), Positives = 62/108 (57%), Gaps = 1/108 (0%)
Query: 88 TTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHS 147
T + +LL E + N +TPLH AA GH++ V L+ + A +T G+TPLH
Sbjct: 516 TNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHV 575
Query: 148 ACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLL 195
A K+ RVA LL+ DA NA K LTPLH+A + ++ D ++LLL
Sbjct: 576 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAV-HHNNLDIVKLLL 622
Score = 72.4 bits (176), Expect = 3e-13
Identities = 41/106 (38%), Positives = 62/106 (58%), Gaps = 1/106 (0%)
Query: 90 VRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSAC 149
V +LL + VN ++ TPLH A+ G++ +V+ L+ +GA + T D TPLH A
Sbjct: 254 VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAA 313
Query: 150 KWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLL 195
+ + R++ LL H A I A+TK L+P+H+AA D D + LLL
Sbjct: 314 RNGHVRISEILLDHGAPIQAKTKNGLSPIHMAA-QGDHLDCVRLLL 358
Score = 66.2 bits (160), Expect = 2e-11
Identities = 45/143 (31%), Positives = 69/143 (48%), Gaps = 6/143 (4%)
Query: 88 TTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHS 147
T V + L + VN + +D+ TPLH AA GH ++V+ L+ A+ + T G TPLH
Sbjct: 483 TEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHI 542
Query: 148 ACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNRYVKPGLKNN 207
A + + LL+ +A TK TPLH+AA + K + LL+ R P
Sbjct: 543 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAA--KYGKVRVAELLLERDAHPNAAGK 600
Query: 208 LEETAFDIARRTSIYHYLFEIVE 230
T +A ++H +IV+
Sbjct: 601 NGLTPLHVA----VHHNNLDIVK 619
Score = 64.7 bits (156), Expect = 7e-11
Identities = 43/130 (33%), Positives = 65/130 (50%)
Query: 79 LWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVT 138
L A +N T +L + + + + +TPLH AA+ +L++ Q L+ +GA V+
Sbjct: 210 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 269
Query: 139 VDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNR 198
+G TPLH A + N + LL A I +TK LTPLH AA N + + LL
Sbjct: 270 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGA 329
Query: 199 YVKPGLKNNL 208
++ KN L
Sbjct: 330 PIQAKTKNGL 339
Score = 60.1 bits (144), Expect = 2e-09
Identities = 42/110 (38%), Positives = 63/110 (57%), Gaps = 10/110 (9%)
Query: 90 VRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSAC 149
VR L++ A +VN + + +TPL+ AA HL++V+ L+ GA+ + T DG+TPL A
Sbjct: 127 VRELVNYGA-NVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVAL 185
Query: 150 KWNNTRVASFLLQHDADINAQTKG--LLTPLHLAAGNRDSKDTLELLLMN 197
+ + V + L IN TKG L LH+AA N D++ T +LL N
Sbjct: 186 QQGHENVVAHL------INYGTKGKVRLPALHIAARNDDTR-TAAVLLQN 228
Score = 58.5 bits (140), Expect = 5e-09
Identities = 36/101 (35%), Positives = 59/101 (58%), Gaps = 1/101 (0%)
Query: 81 AAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVD 140
A+++ + V LL K + T + T LH AA +G ++V+EL+ GA+V+A +
Sbjct: 85 ASKEGHVKMVVELL-HKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK 143
Query: 141 GWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLA 181
G+TPL+ A + N+ V FLL++ A+ N T+ TPL +A
Sbjct: 144 GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA 184
Score = 58.2 bits (139), Expect = 6e-09
Identities = 51/170 (30%), Positives = 70/170 (41%), Gaps = 32/170 (18%)
Query: 78 LLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELI--------- 128
L AA++N L V+ LL E + N ED +TPL A GH ++V LI
Sbjct: 148 LYMAAQENHLEVVKFLL-ENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR 206
Query: 129 -------AQGADVHAVTV-------------DGWTPLHSACKWNNTRVASFLLQHDADIN 168
A+ D V G+TPLH A + N VA LL A +N
Sbjct: 207 LPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN 266
Query: 169 AQTKGLLTPLHLAAGNRDSKDTLELLLMNRYVKPGLKNNLEETAFDIARR 218
+ +TPLH+A +R + LL++R + K E T A R
Sbjct: 267 FTPQNGITPLHIA--SRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAAR 314
Score = 56.6 bits (135), Expect = 2e-08
Identities = 39/148 (26%), Positives = 72/148 (48%), Gaps = 2/148 (1%)
Query: 50 DEDEEQDDKNEEWYRLQEKKMEKDPSRLLLWAAEKNRLTTVRRLLSEKATHVNTRDEDEY 109
++ E+++ + R +++K + D + L AA L L +NT +++
Sbjct: 21 EQKEKEESNRKRRNRSRDRKKKADAATSFLRAARSGNLDKALDHL-RNGVDINTCNQNGL 79
Query: 110 TPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADINA 169
LH A+ GH+ +V EL+ + + T G T LH A V L+ + A++NA
Sbjct: 80 NGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNA 139
Query: 170 QTKGLLTPLHLAAGNRDSKDTLELLLMN 197
Q++ TPL++AA + + ++ LL N
Sbjct: 140 QSQKGFTPLYMAA-QENHLEVVKFLLEN 166
Score = 55.1 bits (131), Expect = 5e-08
Identities = 28/73 (38%), Positives = 46/73 (63%)
Query: 109 YTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADIN 168
YTPLH A++ G++ +V+ L+ ADV+A T G++PLH A + +T + + LL++ A N
Sbjct: 735 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 794
Query: 169 AQTKGLLTPLHLA 181
+ TPL +A
Sbjct: 795 EVSSDGTTPLAIA 807
Score = 47.8 bits (112), Expect = 9e-06
Identities = 27/65 (41%), Positives = 38/65 (58%), Gaps = 1/65 (1%)
Query: 81 AAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVD 140
A+ + V+ LL +A VN + + Y+PLH+AA GH DIV L+ GA + V+ D
Sbjct: 741 ASHYGNIKLVKFLLQHQAD-VNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSD 799
Query: 141 GWTPL 145
G TPL
Sbjct: 800 GTTPL 804
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 81.3 bits (199), Expect = 7e-16
Identities = 49/117 (41%), Positives = 66/117 (56%), Gaps = 2/117 (1%)
Query: 81 AAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVD 140
AA++ V LLS++A N ++ TPLH A GH+ + LI G V A T
Sbjct: 642 AAQEGHAEMVALLLSKQANG-NLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRM 700
Query: 141 GWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMN 197
G+TPLH A + N ++ FLLQH AD+NA+TK +PLH AA + D + LLL N
Sbjct: 701 GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAA-QQGHTDIVTLLLKN 756
Score = 80.5 bits (197), Expect = 1e-15
Identities = 52/150 (34%), Positives = 75/150 (50%), Gaps = 3/150 (2%)
Query: 81 AAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVD 140
A +KN + + LL A+ ++ E TPLH A++ GHL IV+ L+ +GA + V
Sbjct: 378 ACKKNHVRVMELLLKTGAS-IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVK 436
Query: 141 GWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNRYV 200
TPLH A + +T VA +LLQ+ A +NA+ K TPLH AA R + LL+
Sbjct: 437 VETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAA--RIGHTNMVKLLLENNA 494
Query: 201 KPGLKNNLEETAFDIARRTSIYHYLFEIVE 230
P L T IA R + ++E
Sbjct: 495 NPNLATTAGHTPLHIAAREGHVETVLALLE 524
Score = 78.2 bits (191), Expect = 6e-15
Identities = 55/150 (36%), Positives = 79/150 (52%), Gaps = 6/150 (4%)
Query: 81 AAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVD 140
AA+ + L VR LL A ++ D TPLH AA+ GH + + L+ +GA ++ ++
Sbjct: 312 AAQGDHLDCVRLLLQYDA-EIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN 370
Query: 141 GWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNRYV 200
G+TPLH ACK N+ RV LL+ A I+A T+ LTPLH+A+ LL R
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL--QRGA 428
Query: 201 KPGLKNNLEETAFDIARR---TSIYHYLFE 227
P + N ET +A R T + YL +
Sbjct: 429 SPNVSNVKVETPLHMAARAGHTEVAKYLLQ 458
Score = 77.8 bits (190), Expect = 8e-15
Identities = 47/128 (36%), Positives = 68/128 (53%), Gaps = 2/128 (1%)
Query: 79 LWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVT 138
L A K V LL E+ H N ++ TPLH A + +LDIV+ L+ +G H+
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 599
Query: 139 VDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNR 198
+G+TPLH A K N VA LLQ+ NA++ +TPLHLAA ++ + LL+++
Sbjct: 600 WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAA--QEGHAEMVALLLSK 657
Query: 199 YVKPGLKN 206
L N
Sbjct: 658 QANGNLGN 665
Score = 75.1 bits (183), Expect = 5e-14
Identities = 38/91 (41%), Positives = 58/91 (63%)
Query: 92 RLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKW 151
RLL ++ + T+ +DE TPLH AA +GH+ I + L+ GA + A T +G +P+H A +
Sbjct: 256 RLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQG 315
Query: 152 NNTRVASFLLQHDADINAQTKGLLTPLHLAA 182
++ LLQ+DA+I+ T LTPLH+AA
Sbjct: 316 DHLDCVRLLLQYDAEIDDITLDHLTPLHVAA 346
Score = 74.7 bits (182), Expect = 7e-14
Identities = 44/108 (40%), Positives = 62/108 (57%), Gaps = 1/108 (0%)
Query: 88 TTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHS 147
T + +LL E + N +TPLH AA GH++ V L+ + A +T G+TPLH
Sbjct: 483 TNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHV 542
Query: 148 ACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLL 195
A K+ RVA LL+ DA NA K LTPLH+A + ++ D ++LLL
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAV-HHNNLDIVKLLL 589
Score = 72.4 bits (176), Expect = 3e-13
Identities = 41/106 (38%), Positives = 62/106 (58%), Gaps = 1/106 (0%)
Query: 90 VRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSAC 149
V +LL + VN ++ TPLH A+ G++ +V+ L+ +GA + T D TPLH A
Sbjct: 221 VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAA 280
Query: 150 KWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLL 195
+ + R++ LL H A I A+TK L+P+H+AA D D + LLL
Sbjct: 281 RNGHVRISEILLDHGAPIQAKTKNGLSPIHMAA-QGDHLDCVRLLL 325
Score = 66.2 bits (160), Expect = 2e-11
Identities = 45/143 (31%), Positives = 69/143 (48%), Gaps = 6/143 (4%)
Query: 88 TTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHS 147
T V + L + VN + +D+ TPLH AA GH ++V+ L+ A+ + T G TPLH
Sbjct: 450 TEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHI 509
Query: 148 ACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNRYVKPGLKNN 207
A + + LL+ +A TK TPLH+AA + K + LL+ R P
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAA--KYGKVRVAELLLERDAHPNAAGK 567
Query: 208 LEETAFDIARRTSIYHYLFEIVE 230
T +A ++H +IV+
Sbjct: 568 NGLTPLHVA----VHHNNLDIVK 586
Score = 64.7 bits (156), Expect = 7e-11
Identities = 43/130 (33%), Positives = 65/130 (50%)
Query: 79 LWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVT 138
L A +N T +L + + + + +TPLH AA+ +L++ Q L+ +GA V+
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 236
Query: 139 VDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNR 198
+G TPLH A + N + LL A I +TK LTPLH AA N + + LL
Sbjct: 237 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGA 296
Query: 199 YVKPGLKNNL 208
++ KN L
Sbjct: 297 PIQAKTKNGL 306
Score = 60.1 bits (144), Expect = 2e-09
Identities = 42/110 (38%), Positives = 63/110 (57%), Gaps = 10/110 (9%)
Query: 90 VRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSAC 149
VR L++ A +VN + + +TPL+ AA HL++V+ L+ GA+ + T DG+TPL A
Sbjct: 94 VRELVNYGA-NVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVAL 152
Query: 150 KWNNTRVASFLLQHDADINAQTKG--LLTPLHLAAGNRDSKDTLELLLMN 197
+ + V + L IN TKG L LH+AA N D++ T +LL N
Sbjct: 153 QQGHENVVAHL------INYGTKGKVRLPALHIAARNDDTR-TAAVLLQN 195
Score = 58.5 bits (140), Expect = 5e-09
Identities = 36/101 (35%), Positives = 59/101 (58%), Gaps = 1/101 (0%)
Query: 81 AAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVD 140
A+++ + V LL K + T + T LH AA +G ++V+EL+ GA+V+A +
Sbjct: 52 ASKEGHVKMVVELL-HKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK 110
Query: 141 GWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLA 181
G+TPL+ A + N+ V FLL++ A+ N T+ TPL +A
Sbjct: 111 GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA 151
Score = 58.2 bits (139), Expect = 6e-09
Identities = 51/170 (30%), Positives = 70/170 (41%), Gaps = 32/170 (18%)
Query: 78 LLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELI--------- 128
L AA++N L V+ LL E + N ED +TPL A GH ++V LI
Sbjct: 115 LYMAAQENHLEVVKFLL-ENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR 173
Query: 129 -------AQGADVHAVTV-------------DGWTPLHSACKWNNTRVASFLLQHDADIN 168
A+ D V G+TPLH A + N VA LL A +N
Sbjct: 174 LPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN 233
Query: 169 AQTKGLLTPLHLAAGNRDSKDTLELLLMNRYVKPGLKNNLEETAFDIARR 218
+ +TPLH+A +R + LL++R + K E T A R
Sbjct: 234 FTPQNGITPLHIA--SRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAAR 281
Score = 55.1 bits (131), Expect = 5e-08
Identities = 28/73 (38%), Positives = 46/73 (63%)
Query: 109 YTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADIN 168
YTPLH A++ G++ +V+ L+ ADV+A T G++PLH A + +T + + LL++ A N
Sbjct: 702 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761
Query: 169 AQTKGLLTPLHLA 181
+ TPL +A
Sbjct: 762 EVSSDGTTPLAIA 774
Score = 50.1 bits (118), Expect = 2e-06
Identities = 37/127 (29%), Positives = 60/127 (47%), Gaps = 2/127 (1%)
Query: 71 EKDPSRLLLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQ 130
E D + L AA L L +NT +++ LH A+ GH+ +V EL+ +
Sbjct: 9 EADAATSFLRAARSGNLDKALDHL-RNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 67
Query: 131 GADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDT 190
+ T G T LH A V L+ + A++NAQ++ TPL++AA + +
Sbjct: 68 EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAA-QENHLEV 126
Query: 191 LELLLMN 197
++ LL N
Sbjct: 127 VKFLLEN 133
Score = 47.8 bits (112), Expect = 9e-06
Identities = 27/65 (41%), Positives = 38/65 (58%), Gaps = 1/65 (1%)
Query: 81 AAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVD 140
A+ + V+ LL +A VN + + Y+PLH+AA GH DIV L+ GA + V+ D
Sbjct: 708 ASHYGNIKLVKFLLQHQAD-VNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSD 766
Query: 141 GWTPL 145
G TPL
Sbjct: 767 GTTPL 771
Score = 43.9 bits (102), Expect = 1e-04
Identities = 27/82 (32%), Positives = 40/82 (48%)
Query: 101 VNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFL 160
V R+ D T RAA SG+LD + + G D++ +G LH A K + ++ L
Sbjct: 5 VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64
Query: 161 LQHDADINAQTKGLLTPLHLAA 182
L + + TK T LH+AA
Sbjct: 65 LHKEIILETTTKKGNTALHIAA 86
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 81.3 bits (199), Expect = 7e-16
Identities = 49/117 (41%), Positives = 66/117 (56%), Gaps = 2/117 (1%)
Query: 81 AAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVD 140
AA++ V LLS++A N ++ TPLH A GH+ + LI G V A T
Sbjct: 642 AAQEGHAEMVALLLSKQANG-NLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRM 700
Query: 141 GWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMN 197
G+TPLH A + N ++ FLLQH AD+NA+TK +PLH AA + D + LLL N
Sbjct: 701 GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAA-QQGHTDIVTLLLKN 756
Score = 80.5 bits (197), Expect = 1e-15
Identities = 52/150 (34%), Positives = 75/150 (50%), Gaps = 3/150 (2%)
Query: 81 AAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVD 140
A +KN + + LL A+ ++ E TPLH A++ GHL IV+ L+ +GA + V
Sbjct: 378 ACKKNHVRVMELLLKTGAS-IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVK 436
Query: 141 GWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNRYV 200
TPLH A + +T VA +LLQ+ A +NA+ K TPLH AA R + LL+
Sbjct: 437 VETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAA--RIGHTNMVKLLLENNA 494
Query: 201 KPGLKNNLEETAFDIARRTSIYHYLFEIVE 230
P L T IA R + ++E
Sbjct: 495 NPNLATTAGHTPLHIAAREGHVETVLALLE 524
Score = 78.2 bits (191), Expect = 6e-15
Identities = 55/150 (36%), Positives = 79/150 (52%), Gaps = 6/150 (4%)
Query: 81 AAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVD 140
AA+ + L VR LL A ++ D TPLH AA+ GH + + L+ +GA ++ ++
Sbjct: 312 AAQGDHLDCVRLLLQYDA-EIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN 370
Query: 141 GWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNRYV 200
G+TPLH ACK N+ RV LL+ A I+A T+ LTPLH+A+ LL R
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL--QRGA 428
Query: 201 KPGLKNNLEETAFDIARR---TSIYHYLFE 227
P + N ET +A R T + YL +
Sbjct: 429 SPNVSNVKVETPLHMAARAGHTEVAKYLLQ 458
Score = 77.8 bits (190), Expect = 8e-15
Identities = 47/128 (36%), Positives = 68/128 (53%), Gaps = 2/128 (1%)
Query: 79 LWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVT 138
L A K V LL E+ H N ++ TPLH A + +LDIV+ L+ +G H+
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 599
Query: 139 VDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNR 198
+G+TPLH A K N VA LLQ+ NA++ +TPLHLAA ++ + LL+++
Sbjct: 600 WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAA--QEGHAEMVALLLSK 657
Query: 199 YVKPGLKN 206
L N
Sbjct: 658 QANGNLGN 665
Score = 75.1 bits (183), Expect = 5e-14
Identities = 38/91 (41%), Positives = 58/91 (63%)
Query: 92 RLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKW 151
RLL ++ + T+ +DE TPLH AA +GH+ I + L+ GA + A T +G +P+H A +
Sbjct: 256 RLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQG 315
Query: 152 NNTRVASFLLQHDADINAQTKGLLTPLHLAA 182
++ LLQ+DA+I+ T LTPLH+AA
Sbjct: 316 DHLDCVRLLLQYDAEIDDITLDHLTPLHVAA 346
Score = 74.7 bits (182), Expect = 7e-14
Identities = 44/108 (40%), Positives = 62/108 (57%), Gaps = 1/108 (0%)
Query: 88 TTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHS 147
T + +LL E + N +TPLH AA GH++ V L+ + A +T G+TPLH
Sbjct: 483 TNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHV 542
Query: 148 ACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLL 195
A K+ RVA LL+ DA NA K LTPLH+A + ++ D ++LLL
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAV-HHNNLDIVKLLL 589
Score = 72.4 bits (176), Expect = 3e-13
Identities = 41/106 (38%), Positives = 62/106 (58%), Gaps = 1/106 (0%)
Query: 90 VRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSAC 149
V +LL + VN ++ TPLH A+ G++ +V+ L+ +GA + T D TPLH A
Sbjct: 221 VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAA 280
Query: 150 KWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLL 195
+ + R++ LL H A I A+TK L+P+H+AA D D + LLL
Sbjct: 281 RNGHVRISEILLDHGAPIQAKTKNGLSPIHMAA-QGDHLDCVRLLL 325
Score = 66.2 bits (160), Expect = 2e-11
Identities = 45/143 (31%), Positives = 69/143 (48%), Gaps = 6/143 (4%)
Query: 88 TTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHS 147
T V + L + VN + +D+ TPLH AA GH ++V+ L+ A+ + T G TPLH
Sbjct: 450 TEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHI 509
Query: 148 ACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNRYVKPGLKNN 207
A + + LL+ +A TK TPLH+AA + K + LL+ R P
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAA--KYGKVRVAELLLERDAHPNAAGK 567
Query: 208 LEETAFDIARRTSIYHYLFEIVE 230
T +A ++H +IV+
Sbjct: 568 NGLTPLHVA----VHHNNLDIVK 586
Score = 64.7 bits (156), Expect = 7e-11
Identities = 43/130 (33%), Positives = 65/130 (50%)
Query: 79 LWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVT 138
L A +N T +L + + + + +TPLH AA+ +L++ Q L+ +GA V+
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 236
Query: 139 VDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNR 198
+G TPLH A + N + LL A I +TK LTPLH AA N + + LL
Sbjct: 237 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGA 296
Query: 199 YVKPGLKNNL 208
++ KN L
Sbjct: 297 PIQAKTKNGL 306
Score = 60.1 bits (144), Expect = 2e-09
Identities = 42/110 (38%), Positives = 63/110 (57%), Gaps = 10/110 (9%)
Query: 90 VRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSAC 149
VR L++ A +VN + + +TPL+ AA HL++V+ L+ GA+ + T DG+TPL A
Sbjct: 94 VRELVNYGA-NVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVAL 152
Query: 150 KWNNTRVASFLLQHDADINAQTKG--LLTPLHLAAGNRDSKDTLELLLMN 197
+ + V + L IN TKG L LH+AA N D++ T +LL N
Sbjct: 153 QQGHENVVAHL------INYGTKGKVRLPALHIAARNDDTR-TAAVLLQN 195
Score = 58.5 bits (140), Expect = 5e-09
Identities = 36/101 (35%), Positives = 59/101 (58%), Gaps = 1/101 (0%)
Query: 81 AAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVD 140
A+++ + V LL K + T + T LH AA +G ++V+EL+ GA+V+A +
Sbjct: 52 ASKEGHVKMVVELL-HKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK 110
Query: 141 GWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLA 181
G+TPL+ A + N+ V FLL++ A+ N T+ TPL +A
Sbjct: 111 GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA 151
Score = 58.2 bits (139), Expect = 6e-09
Identities = 51/170 (30%), Positives = 70/170 (41%), Gaps = 32/170 (18%)
Query: 78 LLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELI--------- 128
L AA++N L V+ LL E + N ED +TPL A GH ++V LI
Sbjct: 115 LYMAAQENHLEVVKFLL-ENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR 173
Query: 129 -------AQGADVHAVTV-------------DGWTPLHSACKWNNTRVASFLLQHDADIN 168
A+ D V G+TPLH A + N VA LL A +N
Sbjct: 174 LPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN 233
Query: 169 AQTKGLLTPLHLAAGNRDSKDTLELLLMNRYVKPGLKNNLEETAFDIARR 218
+ +TPLH+A +R + LL++R + K E T A R
Sbjct: 234 FTPQNGITPLHIA--SRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAAR 281
Score = 55.1 bits (131), Expect = 5e-08
Identities = 28/73 (38%), Positives = 46/73 (63%)
Query: 109 YTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADIN 168
YTPLH A++ G++ +V+ L+ ADV+A T G++PLH A + +T + + LL++ A N
Sbjct: 702 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761
Query: 169 AQTKGLLTPLHLA 181
+ TPL +A
Sbjct: 762 EVSSDGTTPLAIA 774
Score = 50.1 bits (118), Expect = 2e-06
Identities = 37/127 (29%), Positives = 60/127 (47%), Gaps = 2/127 (1%)
Query: 71 EKDPSRLLLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQ 130
E D + L AA L L +NT +++ LH A+ GH+ +V EL+ +
Sbjct: 9 EADAATSFLRAARSGNLDKALDHL-RNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 67
Query: 131 GADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDT 190
+ T G T LH A V L+ + A++NAQ++ TPL++AA + +
Sbjct: 68 EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAA-QENHLEV 126
Query: 191 LELLLMN 197
++ LL N
Sbjct: 127 VKFLLEN 133
Score = 47.8 bits (112), Expect = 9e-06
Identities = 27/65 (41%), Positives = 38/65 (58%), Gaps = 1/65 (1%)
Query: 81 AAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVD 140
A+ + V+ LL +A VN + + Y+PLH+AA GH DIV L+ GA + V+ D
Sbjct: 708 ASHYGNIKLVKFLLQHQAD-VNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSD 766
Query: 141 GWTPL 145
G TPL
Sbjct: 767 GTTPL 771
Score = 43.9 bits (102), Expect = 1e-04
Identities = 27/82 (32%), Positives = 40/82 (48%)
Query: 101 VNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFL 160
V R+ D T RAA SG+LD + + G D++ +G LH A K + ++ L
Sbjct: 5 VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64
Query: 161 LQHDADINAQTKGLLTPLHLAA 182
L + + TK T LH+AA
Sbjct: 65 LHKEIILETTTKKGNTALHIAA 86
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 81.3 bits (199), Expect = 7e-16
Identities = 49/117 (41%), Positives = 66/117 (56%), Gaps = 2/117 (1%)
Query: 81 AAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVD 140
AA++ V LLS++A N ++ TPLH A GH+ + LI G V A T
Sbjct: 642 AAQEGHAEMVALLLSKQANG-NLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRM 700
Query: 141 GWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMN 197
G+TPLH A + N ++ FLLQH AD+NA+TK +PLH AA + D + LLL N
Sbjct: 701 GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAA-QQGHTDIVTLLLKN 756
Score = 80.5 bits (197), Expect = 1e-15
Identities = 52/150 (34%), Positives = 75/150 (50%), Gaps = 3/150 (2%)
Query: 81 AAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVD 140
A +KN + + LL A+ ++ E TPLH A++ GHL IV+ L+ +GA + V
Sbjct: 378 ACKKNHVRVMELLLKTGAS-IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVK 436
Query: 141 GWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNRYV 200
TPLH A + +T VA +LLQ+ A +NA+ K TPLH AA R + LL+
Sbjct: 437 VETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAA--RIGHTNMVKLLLENNA 494
Query: 201 KPGLKNNLEETAFDIARRTSIYHYLFEIVE 230
P L T IA R + ++E
Sbjct: 495 NPNLATTAGHTPLHIAAREGHVETVLALLE 524
Score = 78.2 bits (191), Expect = 6e-15
Identities = 55/150 (36%), Positives = 79/150 (52%), Gaps = 6/150 (4%)
Query: 81 AAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVD 140
AA+ + L VR LL A ++ D TPLH AA+ GH + + L+ +GA ++ ++
Sbjct: 312 AAQGDHLDCVRLLLQYDA-EIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN 370
Query: 141 GWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNRYV 200
G+TPLH ACK N+ RV LL+ A I+A T+ LTPLH+A+ LL R
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL--QRGA 428
Query: 201 KPGLKNNLEETAFDIARR---TSIYHYLFE 227
P + N ET +A R T + YL +
Sbjct: 429 SPNVSNVKVETPLHMAARAGHTEVAKYLLQ 458
Score = 77.8 bits (190), Expect = 8e-15
Identities = 47/128 (36%), Positives = 68/128 (53%), Gaps = 2/128 (1%)
Query: 79 LWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVT 138
L A K V LL E+ H N ++ TPLH A + +LDIV+ L+ +G H+
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 599
Query: 139 VDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNR 198
+G+TPLH A K N VA LLQ+ NA++ +TPLHLAA ++ + LL+++
Sbjct: 600 WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAA--QEGHAEMVALLLSK 657
Query: 199 YVKPGLKN 206
L N
Sbjct: 658 QANGNLGN 665
Score = 75.1 bits (183), Expect = 5e-14
Identities = 38/91 (41%), Positives = 58/91 (63%)
Query: 92 RLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKW 151
RLL ++ + T+ +DE TPLH AA +GH+ I + L+ GA + A T +G +P+H A +
Sbjct: 256 RLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQG 315
Query: 152 NNTRVASFLLQHDADINAQTKGLLTPLHLAA 182
++ LLQ+DA+I+ T LTPLH+AA
Sbjct: 316 DHLDCVRLLLQYDAEIDDITLDHLTPLHVAA 346
Score = 74.7 bits (182), Expect = 7e-14
Identities = 44/108 (40%), Positives = 62/108 (57%), Gaps = 1/108 (0%)
Query: 88 TTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHS 147
T + +LL E + N +TPLH AA GH++ V L+ + A +T G+TPLH
Sbjct: 483 TNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHV 542
Query: 148 ACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLL 195
A K+ RVA LL+ DA NA K LTPLH+A + ++ D ++LLL
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAV-HHNNLDIVKLLL 589
Score = 72.4 bits (176), Expect = 3e-13
Identities = 41/106 (38%), Positives = 62/106 (58%), Gaps = 1/106 (0%)
Query: 90 VRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSAC 149
V +LL + VN ++ TPLH A+ G++ +V+ L+ +GA + T D TPLH A
Sbjct: 221 VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAA 280
Query: 150 KWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLL 195
+ + R++ LL H A I A+TK L+P+H+AA D D + LLL
Sbjct: 281 RNGHVRISEILLDHGAPIQAKTKNGLSPIHMAA-QGDHLDCVRLLL 325
Score = 66.2 bits (160), Expect = 2e-11
Identities = 45/143 (31%), Positives = 69/143 (48%), Gaps = 6/143 (4%)
Query: 88 TTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHS 147
T V + L + VN + +D+ TPLH AA GH ++V+ L+ A+ + T G TPLH
Sbjct: 450 TEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHI 509
Query: 148 ACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNRYVKPGLKNN 207
A + + LL+ +A TK TPLH+AA + K + LL+ R P
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAA--KYGKVRVAELLLERDAHPNAAGK 567
Query: 208 LEETAFDIARRTSIYHYLFEIVE 230
T +A ++H +IV+
Sbjct: 568 NGLTPLHVA----VHHNNLDIVK 586
Score = 64.7 bits (156), Expect = 7e-11
Identities = 43/130 (33%), Positives = 65/130 (50%)
Query: 79 LWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVT 138
L A +N T +L + + + + +TPLH AA+ +L++ Q L+ +GA V+
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 236
Query: 139 VDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNR 198
+G TPLH A + N + LL A I +TK LTPLH AA N + + LL
Sbjct: 237 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGA 296
Query: 199 YVKPGLKNNL 208
++ KN L
Sbjct: 297 PIQAKTKNGL 306
Score = 60.1 bits (144), Expect = 2e-09
Identities = 42/110 (38%), Positives = 63/110 (57%), Gaps = 10/110 (9%)
Query: 90 VRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSAC 149
VR L++ A +VN + + +TPL+ AA HL++V+ L+ GA+ + T DG+TPL A
Sbjct: 94 VRELVNYGA-NVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVAL 152
Query: 150 KWNNTRVASFLLQHDADINAQTKG--LLTPLHLAAGNRDSKDTLELLLMN 197
+ + V + L IN TKG L LH+AA N D++ T +LL N
Sbjct: 153 QQGHENVVAHL------INYGTKGKVRLPALHIAARNDDTR-TAAVLLQN 195
Score = 58.5 bits (140), Expect = 5e-09
Identities = 36/101 (35%), Positives = 59/101 (58%), Gaps = 1/101 (0%)
Query: 81 AAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVD 140
A+++ + V LL K + T + T LH AA +G ++V+EL+ GA+V+A +
Sbjct: 52 ASKEGHVKMVVELL-HKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK 110
Query: 141 GWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLA 181
G+TPL+ A + N+ V FLL++ A+ N T+ TPL +A
Sbjct: 111 GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA 151
Score = 58.2 bits (139), Expect = 6e-09
Identities = 51/170 (30%), Positives = 70/170 (41%), Gaps = 32/170 (18%)
Query: 78 LLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELI--------- 128
L AA++N L V+ LL E + N ED +TPL A GH ++V LI
Sbjct: 115 LYMAAQENHLEVVKFLL-ENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR 173
Query: 129 -------AQGADVHAVTV-------------DGWTPLHSACKWNNTRVASFLLQHDADIN 168
A+ D V G+TPLH A + N VA LL A +N
Sbjct: 174 LPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN 233
Query: 169 AQTKGLLTPLHLAAGNRDSKDTLELLLMNRYVKPGLKNNLEETAFDIARR 218
+ +TPLH+A +R + LL++R + K E T A R
Sbjct: 234 FTPQNGITPLHIA--SRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAAR 281
Score = 55.1 bits (131), Expect = 5e-08
Identities = 28/73 (38%), Positives = 46/73 (63%)
Query: 109 YTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADIN 168
YTPLH A++ G++ +V+ L+ ADV+A T G++PLH A + +T + + LL++ A N
Sbjct: 702 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761
Query: 169 AQTKGLLTPLHLA 181
+ TPL +A
Sbjct: 762 EVSSDGTTPLAIA 774
Score = 50.1 bits (118), Expect = 2e-06
Identities = 37/127 (29%), Positives = 60/127 (47%), Gaps = 2/127 (1%)
Query: 71 EKDPSRLLLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQ 130
E D + L AA L L +NT +++ LH A+ GH+ +V EL+ +
Sbjct: 9 EADAATSFLRAARSGNLDKALDHL-RNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 67
Query: 131 GADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDT 190
+ T G T LH A V L+ + A++NAQ++ TPL++AA + +
Sbjct: 68 EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAA-QENHLEV 126
Query: 191 LELLLMN 197
++ LL N
Sbjct: 127 VKFLLEN 133
Score = 47.8 bits (112), Expect = 9e-06
Identities = 27/65 (41%), Positives = 38/65 (58%), Gaps = 1/65 (1%)
Query: 81 AAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVD 140
A+ + V+ LL +A VN + + Y+PLH+AA GH DIV L+ GA + V+ D
Sbjct: 708 ASHYGNIKLVKFLLQHQAD-VNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSD 766
Query: 141 GWTPL 145
G TPL
Sbjct: 767 GTTPL 771
Score = 43.9 bits (102), Expect = 1e-04
Identities = 27/82 (32%), Positives = 40/82 (48%)
Query: 101 VNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFL 160
V R+ D T RAA SG+LD + + G D++ +G LH A K + ++ L
Sbjct: 5 VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64
Query: 161 LQHDADINAQTKGLLTPLHLAA 182
L + + TK T LH+AA
Sbjct: 65 LHKEIILETTTKKGNTALHIAA 86
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 81.3 bits (199), Expect = 7e-16
Identities = 49/117 (41%), Positives = 66/117 (56%), Gaps = 2/117 (1%)
Query: 81 AAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVD 140
AA++ V LLS++A N ++ TPLH A GH+ + LI G V A T
Sbjct: 642 AAQEGHAEMVALLLSKQANG-NLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRM 700
Query: 141 GWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMN 197
G+TPLH A + N ++ FLLQH AD+NA+TK +PLH AA + D + LLL N
Sbjct: 701 GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAA-QQGHTDIVTLLLKN 756
Score = 80.5 bits (197), Expect = 1e-15
Identities = 52/150 (34%), Positives = 75/150 (50%), Gaps = 3/150 (2%)
Query: 81 AAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVD 140
A +KN + + LL A+ ++ E TPLH A++ GHL IV+ L+ +GA + V
Sbjct: 378 ACKKNHVRVMELLLKTGAS-IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVK 436
Query: 141 GWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNRYV 200
TPLH A + +T VA +LLQ+ A +NA+ K TPLH AA R + LL+
Sbjct: 437 VETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAA--RIGHTNMVKLLLENNA 494
Query: 201 KPGLKNNLEETAFDIARRTSIYHYLFEIVE 230
P L T IA R + ++E
Sbjct: 495 NPNLATTAGHTPLHIAAREGHVETVLALLE 524
Score = 78.2 bits (191), Expect = 6e-15
Identities = 55/150 (36%), Positives = 79/150 (52%), Gaps = 6/150 (4%)
Query: 81 AAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVD 140
AA+ + L VR LL A ++ D TPLH AA+ GH + + L+ +GA ++ ++
Sbjct: 312 AAQGDHLDCVRLLLQYDA-EIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN 370
Query: 141 GWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNRYV 200
G+TPLH ACK N+ RV LL+ A I+A T+ LTPLH+A+ LL R
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL--QRGA 428
Query: 201 KPGLKNNLEETAFDIARR---TSIYHYLFE 227
P + N ET +A R T + YL +
Sbjct: 429 SPNVSNVKVETPLHMAARAGHTEVAKYLLQ 458
Score = 77.8 bits (190), Expect = 8e-15
Identities = 47/128 (36%), Positives = 68/128 (53%), Gaps = 2/128 (1%)
Query: 79 LWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVT 138
L A K V LL E+ H N ++ TPLH A + +LDIV+ L+ +G H+
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 599
Query: 139 VDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNR 198
+G+TPLH A K N VA LLQ+ NA++ +TPLHLAA ++ + LL+++
Sbjct: 600 WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAA--QEGHAEMVALLLSK 657
Query: 199 YVKPGLKN 206
L N
Sbjct: 658 QANGNLGN 665
Score = 75.1 bits (183), Expect = 5e-14
Identities = 38/91 (41%), Positives = 58/91 (63%)
Query: 92 RLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKW 151
RLL ++ + T+ +DE TPLH AA +GH+ I + L+ GA + A T +G +P+H A +
Sbjct: 256 RLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQG 315
Query: 152 NNTRVASFLLQHDADINAQTKGLLTPLHLAA 182
++ LLQ+DA+I+ T LTPLH+AA
Sbjct: 316 DHLDCVRLLLQYDAEIDDITLDHLTPLHVAA 346
Score = 74.7 bits (182), Expect = 7e-14
Identities = 44/108 (40%), Positives = 62/108 (57%), Gaps = 1/108 (0%)
Query: 88 TTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHS 147
T + +LL E + N +TPLH AA GH++ V L+ + A +T G+TPLH
Sbjct: 483 TNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHV 542
Query: 148 ACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLL 195
A K+ RVA LL+ DA NA K LTPLH+A + ++ D ++LLL
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAV-HHNNLDIVKLLL 589
Score = 72.4 bits (176), Expect = 3e-13
Identities = 41/106 (38%), Positives = 62/106 (58%), Gaps = 1/106 (0%)
Query: 90 VRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSAC 149
V +LL + VN ++ TPLH A+ G++ +V+ L+ +GA + T D TPLH A
Sbjct: 221 VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAA 280
Query: 150 KWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLL 195
+ + R++ LL H A I A+TK L+P+H+AA D D + LLL
Sbjct: 281 RNGHVRISEILLDHGAPIQAKTKNGLSPIHMAA-QGDHLDCVRLLL 325
Score = 66.2 bits (160), Expect = 2e-11
Identities = 45/143 (31%), Positives = 69/143 (48%), Gaps = 6/143 (4%)
Query: 88 TTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHS 147
T V + L + VN + +D+ TPLH AA GH ++V+ L+ A+ + T G TPLH
Sbjct: 450 TEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHI 509
Query: 148 ACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNRYVKPGLKNN 207
A + + LL+ +A TK TPLH+AA + K + LL+ R P
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAA--KYGKVRVAELLLERDAHPNAAGK 567
Query: 208 LEETAFDIARRTSIYHYLFEIVE 230
T +A ++H +IV+
Sbjct: 568 NGLTPLHVA----VHHNNLDIVK 586
Score = 64.7 bits (156), Expect = 7e-11
Identities = 43/130 (33%), Positives = 65/130 (50%)
Query: 79 LWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVT 138
L A +N T +L + + + + +TPLH AA+ +L++ Q L+ +GA V+
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 236
Query: 139 VDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNR 198
+G TPLH A + N + LL A I +TK LTPLH AA N + + LL
Sbjct: 237 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGA 296
Query: 199 YVKPGLKNNL 208
++ KN L
Sbjct: 297 PIQAKTKNGL 306
Score = 60.1 bits (144), Expect = 2e-09
Identities = 42/110 (38%), Positives = 63/110 (57%), Gaps = 10/110 (9%)
Query: 90 VRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSAC 149
VR L++ A +VN + + +TPL+ AA HL++V+ L+ GA+ + T DG+TPL A
Sbjct: 94 VRELVNYGA-NVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVAL 152
Query: 150 KWNNTRVASFLLQHDADINAQTKG--LLTPLHLAAGNRDSKDTLELLLMN 197
+ + V + L IN TKG L LH+AA N D++ T +LL N
Sbjct: 153 QQGHENVVAHL------INYGTKGKVRLPALHIAARNDDTR-TAAVLLQN 195
Score = 58.5 bits (140), Expect = 5e-09
Identities = 36/101 (35%), Positives = 59/101 (58%), Gaps = 1/101 (0%)
Query: 81 AAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVD 140
A+++ + V LL K + T + T LH AA +G ++V+EL+ GA+V+A +
Sbjct: 52 ASKEGHVKMVVELL-HKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK 110
Query: 141 GWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLA 181
G+TPL+ A + N+ V FLL++ A+ N T+ TPL +A
Sbjct: 111 GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA 151
Score = 58.2 bits (139), Expect = 6e-09
Identities = 51/170 (30%), Positives = 70/170 (41%), Gaps = 32/170 (18%)
Query: 78 LLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELI--------- 128
L AA++N L V+ LL E + N ED +TPL A GH ++V LI
Sbjct: 115 LYMAAQENHLEVVKFLL-ENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR 173
Query: 129 -------AQGADVHAVTV-------------DGWTPLHSACKWNNTRVASFLLQHDADIN 168
A+ D V G+TPLH A + N VA LL A +N
Sbjct: 174 LPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN 233
Query: 169 AQTKGLLTPLHLAAGNRDSKDTLELLLMNRYVKPGLKNNLEETAFDIARR 218
+ +TPLH+A +R + LL++R + K E T A R
Sbjct: 234 FTPQNGITPLHIA--SRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAAR 281
Score = 55.1 bits (131), Expect = 5e-08
Identities = 28/73 (38%), Positives = 46/73 (63%)
Query: 109 YTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADIN 168
YTPLH A++ G++ +V+ L+ ADV+A T G++PLH A + +T + + LL++ A N
Sbjct: 702 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761
Query: 169 AQTKGLLTPLHLA 181
+ TPL +A
Sbjct: 762 EVSSDGTTPLAIA 774
Score = 50.1 bits (118), Expect = 2e-06
Identities = 37/127 (29%), Positives = 60/127 (47%), Gaps = 2/127 (1%)
Query: 71 EKDPSRLLLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQ 130
E D + L AA L L +NT +++ LH A+ GH+ +V EL+ +
Sbjct: 9 EADAATSFLRAARSGNLDKALDHL-RNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 67
Query: 131 GADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDT 190
+ T G T LH A V L+ + A++NAQ++ TPL++AA + +
Sbjct: 68 EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAA-QENHLEV 126
Query: 191 LELLLMN 197
++ LL N
Sbjct: 127 VKFLLEN 133
Score = 47.8 bits (112), Expect = 9e-06
Identities = 27/65 (41%), Positives = 38/65 (58%), Gaps = 1/65 (1%)
Query: 81 AAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVD 140
A+ + V+ LL +A VN + + Y+PLH+AA GH DIV L+ GA + V+ D
Sbjct: 708 ASHYGNIKLVKFLLQHQAD-VNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSD 766
Query: 141 GWTPL 145
G TPL
Sbjct: 767 GTTPL 771
Score = 43.9 bits (102), Expect = 1e-04
Identities = 27/82 (32%), Positives = 40/82 (48%)
Query: 101 VNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFL 160
V R+ D T RAA SG+LD + + G D++ +G LH A K + ++ L
Sbjct: 5 VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64
Query: 161 LQHDADINAQTKGLLTPLHLAA 182
L + + TK T LH+AA
Sbjct: 65 LHKEIILETTTKKGNTALHIAA 86
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 79.0 bits (193), Expect = 3e-15
Identities = 53/137 (38%), Positives = 70/137 (51%), Gaps = 14/137 (10%)
Query: 92 RLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKW 151
R L K VN +D ++ TPLH AAY G +I++ LI GA V+A TPLH A
Sbjct: 25 RALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVAS 84
Query: 152 NNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSK--DTLELLLMNRYVKPGLKNNLE 209
+ LL+H AD+NA+ K TPLH+AA N+ K + L LL N V
Sbjct: 85 CSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVS-------- 136
Query: 210 ETAFDIARRTSIYHYLF 226
D A RT+++H F
Sbjct: 137 ----DRAGRTALHHAAF 149
Score = 74.7 bits (182), Expect = 7e-14
Identities = 46/127 (36%), Positives = 66/127 (51%), Gaps = 1/127 (0%)
Query: 71 EKDPSRLLLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQ 130
+K R + WAA + V+ L+S A V +D+ YTPLH AA SG + +V+ L+
Sbjct: 170 DKKDRRAIHWAAYMGHIEVVKLLVSHGA-EVTCKDKKSYTPLHAAASSGMISVVKYLLDL 228
Query: 131 GADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDT 190
G D++ G TPLH AC V + L+ A +N + + TPLH AA +
Sbjct: 229 GVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALC 288
Query: 191 LELLLMN 197
LELL+ N
Sbjct: 289 LELLVGN 295
Score = 62.0 bits (149), Expect = 4e-10
Identities = 33/103 (32%), Positives = 53/103 (51%)
Query: 92 RLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKW 151
+LL + ++N D+ + +H AAY GH+++V+ L++ GA+V +TPLH+A
Sbjct: 157 KLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASS 216
Query: 152 NNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELL 194
V +LL D+N TPLH+A N EL+
Sbjct: 217 GMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELI 259
Score = 59.3 bits (142), Expect = 3e-09
Identities = 33/106 (31%), Positives = 53/106 (50%)
Query: 79 LWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVT 138
L A N+ L ++VN D T LH AA+SGH ++V+ L+++GA+++A
Sbjct: 111 LHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFD 170
Query: 139 VDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGN 184
+H A + V L+ H A++ + K TPLH AA +
Sbjct: 171 KKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASS 216
Score = 54.3 bits (129), Expect = 9e-08
Identities = 39/136 (28%), Positives = 63/136 (46%), Gaps = 6/136 (4%)
Query: 98 ATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVA 157
A+ VN D TPLH AA++ H++ +Q L++ A V++V G TPL A + T
Sbjct: 813 ASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTV 872
Query: 158 SFLLQH-DADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNRYVKPGLKNNLE---ETAF 213
L+ A++ Q T LHLA +T LL++ + L N +T
Sbjct: 873 EMLVSSASAELTLQDNSKNTALHLACSK--GHETSALLILEKITDRNLINATNAALQTPL 930
Query: 214 DIARRTSIYHYLFEIV 229
+A R + + E++
Sbjct: 931 HVAARNGLTMVVQELL 946
Score = 52.4 bits (124), Expect = 3e-07
Identities = 38/121 (31%), Positives = 54/121 (44%), Gaps = 3/121 (2%)
Query: 78 LLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLD---IVQELIAQGADV 134
L+ AAE + TV L+S + + +D + T LH A GH ++ E I +
Sbjct: 860 LMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLI 919
Query: 135 HAVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELL 194
+A TPLH A + T V LL A + A + TP A N+D D L L+
Sbjct: 920 NATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNKDVADCLALI 979
Query: 195 L 195
L
Sbjct: 980 L 980
Score = 50.8 bits (120), Expect = 1e-06
Identities = 43/145 (29%), Positives = 63/145 (43%), Gaps = 6/145 (4%)
Query: 38 PTGTQSLWVGNSDEDEEQDDKNEEWYRLQEKKMEKDPSRLLLWAAEKNRLTTVRRLLSEK 97
P+ Q+++ G+ DE K E+ + + R L AA + LL
Sbjct: 10 PSLVQAIFNGDPDEVRALIFKKED------VNFQDNEKRTPLHAAAYLGDAEIIELLILS 63
Query: 98 ATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVA 157
VN +D TPLHRA S + VQ L+ ADV+A + TPLH A + A
Sbjct: 64 GARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCA 123
Query: 158 SFLLQHDADINAQTKGLLTPLHLAA 182
L+ +++N + T LH AA
Sbjct: 124 EALVPLLSNVNVSDRAGRTALHHAA 148
Score = 50.4 bits (119), Expect = 1e-06
Identities = 29/74 (39%), Positives = 38/74 (51%)
Query: 111 PLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQ 170
PLH AA SG D ++L++ G D+ G T LH+A N + LL AD N +
Sbjct: 375 PLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKK 434
Query: 171 TKGLLTPLHLAAGN 184
K +PLH AA N
Sbjct: 435 DKFGRSPLHYAAAN 448
Score = 50.4 bits (119), Expect = 1e-06
Identities = 42/148 (28%), Positives = 64/148 (43%), Gaps = 35/148 (23%)
Query: 103 TRDEDEYTPLHRAAYSGHLDIVQELIAQ-------------------------------- 130
T D YT LH A Y+GH V+ L+ Q
Sbjct: 751 TADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDT 810
Query: 131 -GAD-VHAVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSK 188
GA V+A G TPLH+A ++ LL H+A +N+ TPL +AA N +
Sbjct: 811 LGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQT- 869
Query: 189 DTLELLLMNRYVKPGLKNNLEETAFDIA 216
+T+E+L+ + + L++N + TA +A
Sbjct: 870 NTVEMLVSSASAELTLQDNSKNTALHLA 897
Score = 50.1 bits (118), Expect = 2e-06
Identities = 39/116 (33%), Positives = 57/116 (49%), Gaps = 2/116 (1%)
Query: 91 RRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACK 150
R+LLS ++T D+ T LH AA G+L+ + L+ GAD + G +PLH A
Sbjct: 389 RKLLSS-GFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAA 447
Query: 151 WNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNRYVKPGLKN 206
N + L+ A +N + TPLH AA + LE LL N PG+++
Sbjct: 448 NCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRND-ANPGIRD 502
Score = 49.7 bits (117), Expect = 2e-06
Identities = 33/105 (31%), Positives = 47/105 (44%)
Query: 78 LLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAV 137
L +AA LL VN + +D TPLH A G Q +I GA +
Sbjct: 276 LHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCE 335
Query: 138 TVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAA 182
+G TPLH A ++ + + + L+ AD + + PLHLAA
Sbjct: 336 DKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAA 380
Score = 48.1 bits (113), Expect = 7e-06
Identities = 36/110 (32%), Positives = 51/110 (46%), Gaps = 3/110 (2%)
Query: 76 RLLLWAAEKNRLTTVRRLL---SEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGA 132
R + AA N + RLL +E V+ +D + TPL + +GH D V L+ +GA
Sbjct: 618 RTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGA 677
Query: 133 DVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAA 182
+V A G T LH + LLQH A + TP+HL+A
Sbjct: 678 NVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSA 727
Score = 44.7 bits (104), Expect = 7e-05
Identities = 45/160 (28%), Positives = 64/160 (40%), Gaps = 7/160 (4%)
Query: 72 KDPSRLLLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQG 131
KD L A R + + ++ A ++ D++ TPLH AA GH ++ LI G
Sbjct: 304 KDGKTPLHMTALHGRFSRSQTIIQSGAV-IDCEDKNGNTPLHIAARYGHELLINTLITSG 362
Query: 132 ADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAA--GNRDSKD 189
AD + G PLH A + LL DI+ T LH AA GN + +
Sbjct: 363 ADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLN 422
Query: 190 TLELLLMNRYVKPGLKNNLEETAFDIARRTSIYHYLFEIV 229
LL+N K+ + A Y LF +V
Sbjct: 423 ----LLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALV 458
Score = 42.4 bits (98), Expect = 4e-04
Identities = 27/84 (32%), Positives = 46/84 (54%), Gaps = 1/84 (1%)
Query: 112 LHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQT 171
L +A ++G D V+ LI + DV+ + TPLH+A + + L+ A +NA+
Sbjct: 12 LVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKD 71
Query: 172 KGLLTPLHLAAGNRDSKDTLELLL 195
LTPLH A + S++ +++LL
Sbjct: 72 SKWLTPLHRAVAS-CSEEAVQVLL 94
Score = 42.4 bits (98), Expect = 4e-04
Identities = 34/106 (32%), Positives = 48/106 (45%), Gaps = 5/106 (4%)
Query: 94 LSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNN 153
L K +V+ +D+ T LHR A +GH + V L+ GA G TP+H + +
Sbjct: 672 LLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGH 731
Query: 154 TRVASFLLQHDADINAQTKGL----LTPLHLAAGNRDSKDTLELLL 195
V LLQ A ++A T LH A N + +ELLL
Sbjct: 732 IGVLGALLQSAASMDANPATADNHGYTALHWACYN-GHETCVELLL 776
Score = 41.2 bits (95), Expect = 8e-04
Identities = 37/132 (28%), Positives = 58/132 (43%), Gaps = 8/132 (6%)
Query: 20 FSEHFNQLELLETHGHLI----PTGTQSLWVGNSDEDEEQDDKNEEWYRLQEKKMEKDPS 75
F++H L+LL +H + TG L + + + + + +
Sbjct: 832 FTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKN 891
Query: 76 RLLLWAAEKNRLTTVRRLLSEKATH---VNTRDEDEYTPLHRAAYSGHLDIVQELIAQGA 132
L A K T+ +L EK T +N + TPLH AA +G +VQEL+ +GA
Sbjct: 892 TALHLACSKGHETSALLIL-EKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGA 950
Query: 133 DVHAVTVDGWTP 144
V AV +G+TP
Sbjct: 951 SVLAVDENGYTP 962
Score = 40.0 bits (92), Expect = 0.002
Identities = 31/111 (27%), Positives = 50/111 (45%), Gaps = 1/111 (0%)
Query: 73 DPSRLLLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGA 132
D R L AA LL N +D+ +PLH AA + + + L+ GA
Sbjct: 403 DFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGA 462
Query: 133 DVHAVTVDGWTPLH-SACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAA 182
V+ + G TPLH +A + + +LL++DA+ + K +H +A
Sbjct: 463 SVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSA 513
Score = 40.0 bits (92), Expect = 0.002
Identities = 30/89 (33%), Positives = 41/89 (46%), Gaps = 2/89 (2%)
Query: 110 TPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADINA 169
+PLH AAY GH ++ L+ D+ G TPL A + L+ A I
Sbjct: 552 SPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILV 611
Query: 170 QTKGL-LTPLHLAAGNRDSKDTLELLLMN 197
+ L TP+H AA N S + L LL+ N
Sbjct: 612 KDYILKRTPIHAAATNGHS-ECLRLLIGN 639
Score = 35.8 bits (81), Expect = 0.034
Identities = 30/106 (28%), Positives = 48/106 (45%), Gaps = 4/106 (3%)
Query: 93 LLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVT-VDGWTPLHSACKW 151
+L + ++ R+ TPL AA+ GH++ V LI QGA + + TP+H+A
Sbjct: 568 VLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATN 627
Query: 152 NNTRVASFLLQHDADINA---QTKGLLTPLHLAAGNRDSKDTLELL 194
++ L+ + NA Q TPL L+ N + LL
Sbjct: 628 GHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLL 673
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 78.2 bits (191), Expect = 6e-15
Identities = 48/145 (33%), Positives = 73/145 (50%), Gaps = 2/145 (1%)
Query: 73 DPSRLLLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGA 132
+ R LL AA+ + TV++L + ++ + + + TPLH AA + +V+ L+ GA
Sbjct: 491 EADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGA 550
Query: 133 DVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLE 192
DVHA G PLH+AC + + VA L++H A +N TPLH AA K +
Sbjct: 551 DVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAK--GKYEIC 608
Query: 193 LLLMNRYVKPGLKNNLEETAFDIAR 217
LL+ P KN T D+ +
Sbjct: 609 KLLLQHGADPTKKNRDGNTPLDLVK 633
Score = 77.8 bits (190), Expect = 8e-15
Identities = 53/140 (37%), Positives = 77/140 (55%), Gaps = 6/140 (4%)
Query: 78 LLWAAEKNRLTTVRRLLSEKATHVNTRDED--EYTPLHRAAYSGHLDIVQELIAQGADVH 135
LL AA+K L V++L S +VN RD TPLH AA +L++ + L+ GADV+
Sbjct: 649 LLDAAKKGCLARVKKLSSPD--NVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVN 706
Query: 136 AVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLL 195
A G PLH+A + + VA+ L++++A +NA K TPLH AA + + L LL
Sbjct: 707 AQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAA--QKGRTQLCALL 764
Query: 196 MNRYVKPGLKNNLEETAFDI 215
+ P LKN +T D+
Sbjct: 765 LAHGADPTLKNQEGQTPLDL 784
Score = 76.6 bits (187), Expect = 2e-14
Identities = 52/144 (36%), Positives = 78/144 (54%), Gaps = 6/144 (4%)
Query: 75 SRLLLWAAEKNRLTTVRRLLSEKATHVNTRDED--EYTPLHRAAYSGHLDIVQELIAQGA 132
+R L A + V+RL++ + VN+RD + TPLH AA G D+V+ L+ GA
Sbjct: 25 ARELFEACRNGDVERVKRLVTPEK--VNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGA 82
Query: 133 DVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLE 192
+V A G PLH+AC + + V + LL+H AD NA+ TPLH AA K +
Sbjct: 83 NVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAA--IKGKIDVC 140
Query: 193 LLLMNRYVKPGLKNNLEETAFDIA 216
++L+ +P ++N TA D+A
Sbjct: 141 IVLLQHGAEPTIRNTDGRTALDLA 164
Score = 72.8 bits (177), Expect = 2e-13
Identities = 50/141 (35%), Positives = 72/141 (51%), Gaps = 6/141 (4%)
Query: 78 LLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAV 137
LL +A + LL+ + + D + TPLH AA + IVQ L+ GADVHA
Sbjct: 181 LLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAK 240
Query: 138 TVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLEL--LL 195
PLH+AC + + V L++H A +NA TPLH AA SK+ +E+ LL
Sbjct: 241 DKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAA----SKNRVEVCSLL 296
Query: 196 MNRYVKPGLKNNLEETAFDIA 216
++ P L N ++A D+A
Sbjct: 297 LSYGADPTLLNCHNKSAIDLA 317
Score = 59.7 bits (143), Expect = 2e-09
Identities = 38/104 (36%), Positives = 52/104 (50%), Gaps = 1/104 (0%)
Query: 81 AAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVD 140
AA N L LL A VN +D+ PLH AA GH+D+ LI A V+A
Sbjct: 686 AAGYNNLEVAEYLLQHGAD-VNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKW 744
Query: 141 GWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGN 184
+TPLH A + T++ + LL H AD + + TPL L + +
Sbjct: 745 AFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSAD 788
Score = 46.2 bits (108), Expect = 2e-05
Identities = 29/100 (29%), Positives = 49/100 (49%), Gaps = 2/100 (2%)
Query: 93 LLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWN 152
LL K ++N + ++ TPLH A+ H D+V+ ++ A V+A+ G T LH A
Sbjct: 385 LLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCG 444
Query: 153 NTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLE 192
+ + LL + D N + T L + GN + + L+
Sbjct: 445 HLQTCRLLLSYGCDPNIISLQGFTALQM--GNENVQQLLQ 482
Score = 45.1 bits (105), Expect = 6e-05
Identities = 36/122 (29%), Positives = 61/122 (50%), Gaps = 4/122 (3%)
Query: 64 RLQEKKMEKDPSRLLLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAA---YSGH 120
+L+E+ + LL AA + +T +++ LS + + E T LH AA Y
Sbjct: 321 QLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHE-TALHCAAASPYPKR 379
Query: 121 LDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHL 180
I + L+ +GA+++ T + TPLH A + + V +++H+A +NA T LH
Sbjct: 380 KQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHR 439
Query: 181 AA 182
AA
Sbjct: 440 AA 441
Score = 41.6 bits (96), Expect = 6e-04
Identities = 24/65 (36%), Positives = 36/65 (55%), Gaps = 1/65 (1%)
Query: 81 AAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVD 140
A+EK V ++ +A VN D T LHRAAY GHL + L++ G D + +++
Sbjct: 407 ASEKAHNDVVEVVVKHEAK-VNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQ 465
Query: 141 GWTPL 145
G+T L
Sbjct: 466 GFTAL 470
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 77.8 bits (190), Expect = 8e-15
Identities = 52/142 (36%), Positives = 73/142 (51%), Gaps = 6/142 (4%)
Query: 78 LLWAAEKNRLTTVRRLLSEKATHVNTRDED--EYTPLHRAAYSGHLDIVQELIAQGADVH 135
LL A++ L TV++L S + +VN RD + TPLH AA + +V+ L+ GADVH
Sbjct: 654 LLEASKAGDLETVKQLCSSQ--NVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVH 711
Query: 136 AVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLL 195
A G PLH+AC + + VA L++H A +N TPLH AA K + LL
Sbjct: 712 AKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAK--GKYEICKLL 769
Query: 196 MNRYVKPGLKNNLEETAFDIAR 217
+ P KN T D+ +
Sbjct: 770 LKHGADPTKKNRDGNTPLDLVK 791
Score = 76.6 bits (187), Expect = 2e-14
Identities = 53/141 (37%), Positives = 73/141 (51%), Gaps = 6/141 (4%)
Query: 78 LLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAV 137
LL AA + LL+ + + D + TPLH AA + IVQ L+ GADVHA
Sbjct: 339 LLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAK 398
Query: 138 TVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLEL--LL 195
G PLH+AC + + V LL+H A +NA TPLH AA SK+ +E+ LL
Sbjct: 399 DKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAA----SKNRVEVCSLL 454
Query: 196 MNRYVKPGLKNNLEETAFDIA 216
++ P L N ++A D+A
Sbjct: 455 LSHGADPTLVNCHGKSAVDMA 475
Score = 76.6 bits (187), Expect = 2e-14
Identities = 51/152 (33%), Positives = 81/152 (53%), Gaps = 6/152 (3%)
Query: 78 LLWAAEKNRLTTVRRLLSEKATHVNTRDED--EYTPLHRAAYSGHLDIVQELIAQGADVH 135
LL AA+K L V++L + + ++N RD TPLH AA +L++ + L+ GADV+
Sbjct: 807 LLDAAKKGCLARVQKLCTPE--NINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVN 864
Query: 136 AVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLL 195
A G PLH+A + + +A+ L++++ +NA K TPLH AA + + L LL
Sbjct: 865 AQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAA--QKGRTQLCALL 922
Query: 196 MNRYVKPGLKNNLEETAFDIARRTSIYHYLFE 227
+ P +KN +T D+A I L +
Sbjct: 923 LAHGADPTMKNQEGQTPLDLATADDIRALLID 954
Score = 76.3 bits (186), Expect = 2e-14
Identities = 52/143 (36%), Positives = 77/143 (53%), Gaps = 6/143 (4%)
Query: 76 RLLLWAAEKNRLTTVRRLLSEKATHVNTRDED--EYTPLHRAAYSGHLDIVQELIAQGAD 133
R LL A ++ V+RL+ A +VN +D + +PLH AA G D+V+ L+ GA+
Sbjct: 184 RELLEACRNGDVSRVKRLVD--AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGAN 241
Query: 134 VHAVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLEL 193
VHA G PLH+AC + + V S LL AD NA+ TPLH AA K + +
Sbjct: 242 VHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAA--IKGKIDVCI 299
Query: 194 LLMNRYVKPGLKNNLEETAFDIA 216
+L+ P ++N ++A D+A
Sbjct: 300 VLLQHGADPNIRNTDGKSALDLA 322
Score = 49.3 bits (116), Expect = 3e-06
Identities = 27/77 (35%), Positives = 41/77 (53%)
Query: 90 VRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSAC 149
V LL K +VN +++D TPLH AA H D+++ L GA ++A+ G T LH A
Sbjct: 540 VTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAA 599
Query: 150 KWNNTRVASFLLQHDAD 166
+ + LL + +D
Sbjct: 600 LAGHLQTCRLLLSYGSD 616
Score = 41.2 bits (95), Expect = 8e-04
Identities = 37/121 (30%), Positives = 56/121 (46%), Gaps = 4/121 (3%)
Query: 65 LQEKKMEKDPSRLLLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGH---L 121
L+E+ + LL AA + L V++ L+ + + E T LH A S H
Sbjct: 480 LRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHE-TALHCAVASLHPKRK 538
Query: 122 DIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLA 181
+ + L+ +GA+V+ D TPLH A + + V L +H A +NA T LH A
Sbjct: 539 QVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRA 598
Query: 182 A 182
A
Sbjct: 599 A 599
Score = 37.4 bits (85), Expect = 0.012
Identities = 20/65 (30%), Positives = 33/65 (50%)
Query: 79 LWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVT 138
L A + V +L + +N D T LHRAA +GHL + L++ G+D ++
Sbjct: 562 LHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIIS 621
Query: 139 VDGWT 143
+ G+T
Sbjct: 622 LQGFT 626
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 77.4 bits (189), Expect = 1e-14
Identities = 45/127 (35%), Positives = 66/127 (51%), Gaps = 1/127 (0%)
Query: 71 EKDPSRLLLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQ 130
+K R L WAA L V L++ A V +D+ YTPLH AA +G +++V+ L+
Sbjct: 145 DKKDRRALHWAAYMGHLDVVALLINHGA-EVTCKDKKGYTPLHAAASNGQINVVKHLLNL 203
Query: 131 GADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDT 190
G ++ + V G T LH AC V + L+ + A++N TPLH AA +
Sbjct: 204 GVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALC 263
Query: 191 LELLLMN 197
LELL+ N
Sbjct: 264 LELLVNN 270
Score = 74.7 bits (182), Expect = 7e-14
Identities = 40/96 (41%), Positives = 55/96 (57%)
Query: 93 LLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWN 152
+L K VNT D ++ TPLH AA+ G +I++ LI GA V+A TPLH A
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
Query: 153 NTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSK 188
+ L++H AD+NA+ K TPLH+AA N+ K
Sbjct: 61 SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVK 96
Score = 61.2 bits (147), Expect = 7e-10
Identities = 34/106 (32%), Positives = 53/106 (50%)
Query: 79 LWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVT 138
L A N+ ++ + VN D T LH AA +GH+++V L+A+GA+++A
Sbjct: 86 LHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFD 145
Query: 139 VDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGN 184
LH A + V + L+ H A++ + K TPLH AA N
Sbjct: 146 KKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASN 191
Score = 53.5 bits (127), Expect = 2e-07
Identities = 38/117 (32%), Positives = 51/117 (43%)
Query: 78 LLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAV 137
L +AA LL VN + +D +PLH A G Q LI G ++ V
Sbjct: 251 LHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCV 310
Query: 138 TVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELL 194
DG TPLH A ++ + + + L AD + PLHLAA N S +LL
Sbjct: 311 DKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLL 367
Score = 52.0 bits (123), Expect = 5e-07
Identities = 38/115 (33%), Positives = 56/115 (48%), Gaps = 6/115 (5%)
Query: 101 VNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFL 160
V+ RD+ TPL AA++ H++ +Q L+ A V+AV G T L A + L
Sbjct: 807 VSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDIL 866
Query: 161 LQH-DADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNRYVKPGL---KNNLEET 211
+ AD+ + K L TPLHLA K LL++++ L KNN +T
Sbjct: 867 VNSAQADLTVKDKDLNTPLHLACSKGHEK--CALLILDKIQDESLINEKNNALQT 919
Score = 51.2 bits (121), Expect = 8e-07
Identities = 34/92 (36%), Positives = 44/92 (47%)
Query: 93 LLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWN 152
LL VN +D TPLHRA S + VQ LI ADV+A + TPLH A
Sbjct: 34 LLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANK 93
Query: 153 NTRVASFLLQHDADINAQTKGLLTPLHLAAGN 184
+ A ++ + +N +G T LH AA N
Sbjct: 94 AVKCAEVIIPLLSSVNVSDRGGRTALHHAALN 125
Score = 50.8 bits (120), Expect = 1e-06
Identities = 41/124 (33%), Positives = 55/124 (44%), Gaps = 3/124 (2%)
Query: 76 RLLLWAAEKNRLTTVRRLLSEKATH---VNTRDEDEYTPLHRAAYSGHLDIVQELIAQGA 132
R L A+ N T RLL E A + V+ +D TPL A GH+D V L+ + A
Sbjct: 610 RTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEA 669
Query: 133 DVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLE 192
+V V + G T LH + LL+ + I + TPLH AA + E
Sbjct: 670 NVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSE 729
Query: 193 LLLM 196
LL M
Sbjct: 730 LLQM 733
Score = 47.0 bits (110), Expect = 1e-05
Identities = 26/74 (35%), Positives = 36/74 (48%)
Query: 111 PLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQ 170
PLH AA + H D ++L++ G ++ G T LH+A N L AD + +
Sbjct: 350 PLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKK 409
Query: 171 TKGLLTPLHLAAGN 184
K TPLH AA N
Sbjct: 410 DKCGRTPLHYAAAN 423
Score = 43.1 bits (100), Expect = 2e-04
Identities = 31/94 (32%), Positives = 46/94 (48%), Gaps = 1/94 (1%)
Query: 91 RRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACK 150
R+LLS ++T D+ T LH AA G+++ ++ L + GAD H G TPLH A
Sbjct: 364 RKLLSS-GFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAA 422
Query: 151 WNNTRVASFLLQHDADINAQTKGLLTPLHLAAGN 184
+ L+ A++N T LH AA +
Sbjct: 423 NCHFHCIETLVTTGANVNETDDWGRTALHYAAAS 456
Score = 41.6 bits (96), Expect = 6e-04
Identities = 34/111 (30%), Positives = 47/111 (42%), Gaps = 1/111 (0%)
Query: 72 KDPSRLLLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQG 131
KD L A R T + L+ + ++ D+D TPLH AA GH ++ L G
Sbjct: 279 KDGKSPLHMTAVHGRFTRSQTLI-QNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSG 337
Query: 132 ADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAA 182
AD + PLH A ++ LL +I+ K T LH AA
Sbjct: 338 ADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAA 388
Score = 38.1 bits (87), Expect = 0.007
Identities = 22/69 (31%), Positives = 38/69 (55%), Gaps = 1/69 (1%)
Query: 127 LIAQGADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRD 186
LI + DV+ + + TPLH A + + L+ A +NA+ LTPLH A +R
Sbjct: 2 LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR- 60
Query: 187 SKDTLELLL 195
S++ +++L+
Sbjct: 61 SEEAVQVLI 69
Score = 38.1 bits (87), Expect = 0.007
Identities = 39/148 (26%), Positives = 56/148 (37%), Gaps = 29/148 (19%)
Query: 76 RLLLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVH 135
R L AA +LL + +D+ TPLH AA + H ++ L+ GA+V+
Sbjct: 381 RTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVN 440
Query: 136 AVTVDGWTPLHSAC----------------------------KWNNTRVASFLLQHDADI 167
G T LH A + T FLLQ+DA+
Sbjct: 441 ETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANP 500
Query: 168 NAQTKGLLTPLHLAAGNRDSKDTLELLL 195
+ + K +H AA + LELLL
Sbjct: 501 SIRDKEGYNSIHYAAA-YGHRQCLELLL 527
Score = 38.1 bits (87), Expect = 0.007
Identities = 36/122 (29%), Positives = 58/122 (47%), Gaps = 6/122 (4%)
Query: 78 LLWAAEKNRLTTVRRLLSEKATHVNT--RDEDEYTPLHRAAYSGHLDIVQELIAQGADVH 135
L +AA + T + LL + + +D YTPLH A Y+G+ + ++ L+ Q
Sbjct: 715 LHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKC-FR 773
Query: 136 AVTVDGWTPLHSACKWNNTRVASFLLQ--HDADINAQTKGLLTPLHLAAGNRDSKDTLEL 193
+ +TPLH A ++ AS LL + ++ + TPL AA D + L+L
Sbjct: 774 KFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLR-AAAFADHVECLQL 832
Query: 194 LL 195
LL
Sbjct: 833 LL 834
Score = 35.4 bits (80), Expect = 0.044
Identities = 23/71 (32%), Positives = 35/71 (49%), Gaps = 1/71 (1%)
Query: 93 LLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAV-TVDGWTPLHSACKW 151
+L + ++ RDE T L AA+ GH + V+ LI GA + V TPLH++
Sbjct: 560 VLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVIN 619
Query: 152 NNTRVASFLLQ 162
+T LL+
Sbjct: 620 GHTLCLRLLLE 630
Score = 34.3 bits (77), Expect = 0.098
Identities = 46/173 (26%), Positives = 71/173 (41%), Gaps = 27/173 (15%)
Query: 23 HFNQLELLETHGHLIPT----GTQSL-WVGNSDEDEEQD------DKNEEWYRLQEKKME 71
HF+ +E L T G + G +L + SD D + D +EE R +E K
Sbjct: 425 HFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELK-- 482
Query: 72 KDPSRLLLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQG 131
EK + LL A + + RD++ Y +H AA GH ++ L+ +
Sbjct: 483 -----------EKEATLCLEFLLQNDA-NPSIRDKEGYNSIHYAAAYGHRQCLELLLERT 530
Query: 132 ADVHAVTVDGWT--PLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAA 182
+ G T PLH A + + LLQ D++ + + T L LAA
Sbjct: 531 NSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAA 583
Score = 33.5 bits (75), Expect = 0.17
Identities = 28/102 (27%), Positives = 46/102 (45%), Gaps = 3/102 (2%)
Query: 81 AAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTV- 139
AA K V L++ A+ + + TPLH + +GH ++ L+ + AV V
Sbjct: 582 AAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVK 641
Query: 140 --DGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLH 179
G TPL A + + S LL+ +A+++ T LH
Sbjct: 642 DAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALH 683
Score = 31.2 bits (69), Expect = 0.83
Identities = 23/76 (30%), Positives = 33/76 (43%), Gaps = 1/76 (1%)
Query: 110 TPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADINA 169
+PLH AAY+GH ++ L+ D+ G T L A +T L+ A I
Sbjct: 544 SPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFV 603
Query: 170 QTK-GLLTPLHLAAGN 184
+ TPLH + N
Sbjct: 604 KDNVTKRTPLHASVIN 619
Score = 30.4 bits (67), Expect = 1.4
Identities = 15/43 (34%), Positives = 22/43 (51%)
Query: 78 LLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGH 120
L+ AAE + V L++ + +D+D TPLH A GH
Sbjct: 851 LMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGH 893
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 75.9 bits (185), Expect = 3e-14
Identities = 51/140 (36%), Positives = 79/140 (56%), Gaps = 7/140 (5%)
Query: 81 AAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVD 140
AA+ + + V+ LL KA V+ D T LH AA+ GH + + L+ + A+ +A ++
Sbjct: 318 AAQGDHVECVKHLLQHKAP-VDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALN 376
Query: 141 GWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAA--GNRDSKDTLELLLMNR 198
G+TPLH ACK N +V L+++ A I A T+ LTP+H+AA G+ + + LLL+
Sbjct: 377 GFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLN----IVLLLLQN 432
Query: 199 YVKPGLKNNLEETAFDIARR 218
P + N ETA +A R
Sbjct: 433 GASPDVTNIRGETALHMAAR 452
Score = 70.5 bits (171), Expect = 1e-12
Identities = 39/104 (37%), Positives = 59/104 (56%)
Query: 79 LWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVT 138
L A K T + +LL ++ ++ + D TPLH AA SGH +V+ L+ +GA + A T
Sbjct: 249 LHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLART 308
Query: 139 VDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAA 182
+G +PLH A + ++ LLQH A ++ T LT LH+AA
Sbjct: 309 KNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAA 352
Score = 70.5 bits (171), Expect = 1e-12
Identities = 46/140 (32%), Positives = 70/140 (50%), Gaps = 2/140 (1%)
Query: 79 LWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVT 138
L A + T + LL +K +++ + T LH AA +++ L GAD A T
Sbjct: 645 LHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHT 704
Query: 139 VDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNR 198
G+TPL AC + N ++ +FLL+ A++NA+TK TPLH AA + + +L+
Sbjct: 705 KLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAA--QQGHTHIINVLLQH 762
Query: 199 YVKPGLKNNLEETAFDIARR 218
KP TA IA+R
Sbjct: 763 GAKPNATTANGNTALAIAKR 782
Score = 70.1 bits (170), Expect = 2e-12
Identities = 42/115 (36%), Positives = 61/115 (53%), Gaps = 2/115 (1%)
Query: 88 TTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHS 147
T + +LL + H + + YTPLH +A G +D+ L+ GA T G+TPLH
Sbjct: 489 TEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHV 548
Query: 148 ACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNRYVKP 202
A K+ + VA LLQ A ++ K LTPLH+AA + K + LLL+ + P
Sbjct: 549 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQK--VALLLLEKGASP 601
Score = 70.1 bits (170), Expect = 2e-12
Identities = 43/117 (36%), Positives = 64/117 (54%), Gaps = 1/117 (0%)
Query: 79 LWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVT 138
L A K V +LL ++ ++ ++ TPLH AA+ + + L+ +GA HA
Sbjct: 546 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 605
Query: 139 VDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLL 195
+G+TPLH A K N ++AS LL + A+ N TK +TPLHLA+ D + LLL
Sbjct: 606 KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLAS-QEGHTDMVTLLL 661
Score = 68.2 bits (165), Expect = 6e-12
Identities = 40/98 (40%), Positives = 55/98 (56%), Gaps = 2/98 (2%)
Query: 101 VNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFL 160
VN E +TPLH AA+ G++++ L+ +GA V +G TPLH A K NT + L
Sbjct: 205 VNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLL 264
Query: 161 LQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNR 198
L I+A+T+ LTPLH AA R D + LL+ R
Sbjct: 265 LDRGGQIDAKTRDGLTPLHCAA--RSGHDQVVELLLER 300
Score = 68.2 bits (165), Expect = 6e-12
Identities = 48/118 (40%), Positives = 63/118 (53%), Gaps = 2/118 (1%)
Query: 81 AAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVD 140
AA ++ VR LL A V+ R +E TPLH A+ G +IVQ L+ A A T +
Sbjct: 450 AARAGQVEVVRCLLRNGAL-VDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTN 508
Query: 141 GWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNR 198
G+TPLH + + VAS LL+ A + TK TPLH+AA S D +LLL R
Sbjct: 509 GYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAA-KYGSLDVAKLLLQRR 565
Score = 65.5 bits (158), Expect = 4e-11
Identities = 38/93 (40%), Positives = 51/93 (54%)
Query: 90 VRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSAC 149
V LL EK + ++ YTPLH AA + I L+ GA+ + VT G TPLH A
Sbjct: 590 VALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLAS 649
Query: 150 KWNNTRVASFLLQHDADINAQTKGLLTPLHLAA 182
+ +T + + LL A+I+ TK LT LHLAA
Sbjct: 650 QEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAA 682
Score = 64.7 bits (156), Expect = 7e-11
Identities = 43/127 (33%), Positives = 66/127 (51%), Gaps = 2/127 (1%)
Query: 71 EKDPSRLLLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQ 130
+ D + L AA L V L + +NT +++ LH AA GH+ +VQEL+ +
Sbjct: 7 KSDSNASFLRAARAGNLDKVVEYL-KGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 65
Query: 131 GADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDT 190
G+ V + T G T LH A V L++ A+INAQ++ TPL++AA + D
Sbjct: 66 GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAA-QENHIDV 124
Query: 191 LELLLMN 197
++ LL N
Sbjct: 125 VKYLLEN 131
Score = 63.9 bits (154), Expect = 1e-10
Identities = 44/138 (31%), Positives = 65/138 (47%), Gaps = 3/138 (2%)
Query: 81 AAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVD 140
A +KNR+ V LL + + E TP+H AA+ GHL+IV L+ GA +
Sbjct: 384 ACKKNRIK-VMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIR 442
Query: 141 GWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNRYV 200
G T LH A + V LL++ A ++A+ + TPLH+A +R K + LL+
Sbjct: 443 GETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIA--SRLGKTEIVQLLLQHMA 500
Query: 201 KPGLKNNLEETAFDIARR 218
P T I+ R
Sbjct: 501 HPDAATTNGYTPLHISAR 518
Score = 63.5 bits (153), Expect = 2e-10
Identities = 36/108 (33%), Positives = 63/108 (58%), Gaps = 5/108 (4%)
Query: 90 VRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSAC 149
V ++L ++ ++N + ++ +TPL+ AA H+D+V+ L+ GA+ T DG+TPL A
Sbjct: 91 VVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVAL 150
Query: 150 KWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMN 197
+ + + + LL++D + K L LH+AA D+K + LLL N
Sbjct: 151 QQGHNQAVAILLEND----TKGKVRLPALHIAARKDDTK-SAALLLQN 193
Score = 63.5 bits (153), Expect = 2e-10
Identities = 35/93 (37%), Positives = 54/93 (58%)
Query: 90 VRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSAC 149
V LL + V+ + TPLH A+ G+ ++V+ L+ +G + A T DG TPLH A
Sbjct: 227 VATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAA 286
Query: 150 KWNNTRVASFLLQHDADINAQTKGLLTPLHLAA 182
+ + +V LL+ A + A+TK L+PLH+AA
Sbjct: 287 RSGHDQVVELLLERGAPLLARTKNGLSPLHMAA 319
Score = 59.7 bits (143), Expect = 2e-09
Identities = 36/102 (35%), Positives = 55/102 (53%), Gaps = 1/102 (0%)
Query: 81 AAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVD 140
+A + ++ LL A H + + +TPLH AA G LD+ + L+ + A + +
Sbjct: 516 SAREGQVDVASVLLEAGAAH-SLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKN 574
Query: 141 GWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAA 182
G TPLH A ++N +VA LL+ A +A K TPLH+AA
Sbjct: 575 GLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAA 616
Score = 57.0 bits (136), Expect = 1e-08
Identities = 31/101 (30%), Positives = 63/101 (62%), Gaps = 1/101 (0%)
Query: 81 AAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVD 140
AA++ + V+ LL + + V++ + T LH A+ +G ++V+ L+ +GA+++A + +
Sbjct: 50 AAKEGHVGLVQELLG-RGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQN 108
Query: 141 GWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLA 181
G+TPL+ A + N+ V +LL++ A+ + T+ TPL +A
Sbjct: 109 GFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVA 149
Score = 51.6 bits (122), Expect = 6e-07
Identities = 44/155 (28%), Positives = 66/155 (42%), Gaps = 39/155 (25%)
Query: 78 LLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIA-------- 129
L AA++N + V+ LL E + +T ED +TPL A GH V L+
Sbjct: 113 LYMAAQENHIDVVKYLL-ENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVR 171
Query: 130 -----------------------QGADVHA------VTVDGWTPLHSACKWNNTRVASFL 160
ADV + T G+TPLH A + N VA+ L
Sbjct: 172 LPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLL 231
Query: 161 LQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLL 195
L A ++ + +TPLH+A+ R + + ++LLL
Sbjct: 232 LNRGAAVDFTARNGITPLHVAS-KRGNTNMVKLLL 265
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 75.9 bits (185), Expect = 3e-14
Identities = 51/140 (36%), Positives = 79/140 (56%), Gaps = 7/140 (5%)
Query: 81 AAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVD 140
AA+ + + V+ LL KA V+ D T LH AA+ GH + + L+ + A+ +A ++
Sbjct: 339 AAQGDHVECVKHLLQHKAP-VDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALN 397
Query: 141 GWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAA--GNRDSKDTLELLLMNR 198
G+TPLH ACK N +V L+++ A I A T+ LTP+H+AA G+ + + LLL+
Sbjct: 398 GFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLN----IVLLLLQN 453
Query: 199 YVKPGLKNNLEETAFDIARR 218
P + N ETA +A R
Sbjct: 454 GASPDVTNIRGETALHMAAR 473
Score = 70.5 bits (171), Expect = 1e-12
Identities = 39/104 (37%), Positives = 59/104 (56%)
Query: 79 LWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVT 138
L A K T + +LL ++ ++ + D TPLH AA SGH +V+ L+ +GA + A T
Sbjct: 270 LHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLART 329
Query: 139 VDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAA 182
+G +PLH A + ++ LLQH A ++ T LT LH+AA
Sbjct: 330 KNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAA 373
Score = 70.5 bits (171), Expect = 1e-12
Identities = 46/140 (32%), Positives = 70/140 (50%), Gaps = 2/140 (1%)
Query: 79 LWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVT 138
L A + T + LL +K +++ + T LH AA +++ L GAD A T
Sbjct: 666 LHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHT 725
Query: 139 VDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNR 198
G+TPL AC + N ++ +FLL+ A++NA+TK TPLH AA + + +L+
Sbjct: 726 KLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAA--QQGHTHIINVLLQH 783
Query: 199 YVKPGLKNNLEETAFDIARR 218
KP TA IA+R
Sbjct: 784 GAKPNATTANGNTALAIAKR 803
Score = 70.1 bits (170), Expect = 2e-12
Identities = 42/115 (36%), Positives = 61/115 (53%), Gaps = 2/115 (1%)
Query: 88 TTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHS 147
T + +LL + H + + YTPLH +A G +D+ L+ GA T G+TPLH
Sbjct: 510 TEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHV 569
Query: 148 ACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNRYVKP 202
A K+ + VA LLQ A ++ K LTPLH+AA + K + LLL+ + P
Sbjct: 570 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQK--VALLLLEKGASP 622
Score = 70.1 bits (170), Expect = 2e-12
Identities = 43/117 (36%), Positives = 64/117 (54%), Gaps = 1/117 (0%)
Query: 79 LWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVT 138
L A K V +LL ++ ++ ++ TPLH AA+ + + L+ +GA HA
Sbjct: 567 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 626
Query: 139 VDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLL 195
+G+TPLH A K N ++AS LL + A+ N TK +TPLHLA+ D + LLL
Sbjct: 627 KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLAS-QEGHTDMVTLLL 682
Score = 68.2 bits (165), Expect = 6e-12
Identities = 40/98 (40%), Positives = 55/98 (56%), Gaps = 2/98 (2%)
Query: 101 VNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFL 160
VN E +TPLH AA+ G++++ L+ +GA V +G TPLH A K NT + L
Sbjct: 226 VNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLL 285
Query: 161 LQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNR 198
L I+A+T+ LTPLH AA R D + LL+ R
Sbjct: 286 LDRGGQIDAKTRDGLTPLHCAA--RSGHDQVVELLLER 321
Score = 68.2 bits (165), Expect = 6e-12
Identities = 48/118 (40%), Positives = 63/118 (53%), Gaps = 2/118 (1%)
Query: 81 AAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVD 140
AA ++ VR LL A V+ R +E TPLH A+ G +IVQ L+ A A T +
Sbjct: 471 AARAGQVEVVRCLLRNGAL-VDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTN 529
Query: 141 GWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNR 198
G+TPLH + + VAS LL+ A + TK TPLH+AA S D +LLL R
Sbjct: 530 GYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAA-KYGSLDVAKLLLQRR 586
Score = 66.6 bits (161), Expect = 2e-11
Identities = 49/152 (32%), Positives = 75/152 (49%), Gaps = 4/152 (2%)
Query: 48 NSDEDEEQDDKNEEWYRLQEKKMEK--DPSRLLLWAAEKNRLTTVRRLLSEKATHVNTRD 105
N D ++ D + Q +K K D + L AA L V L + +NT +
Sbjct: 3 NEDAAQKSDSGEKFNGSSQRRKRPKKSDSNASFLRAARAGNLDKVVEYL-KGGIDINTCN 61
Query: 106 EDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDA 165
++ LH AA GH+ +VQEL+ +G+ V + T G T LH A V L++ A
Sbjct: 62 QNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGA 121
Query: 166 DINAQTKGLLTPLHLAAGNRDSKDTLELLLMN 197
+INAQ++ TPL++AA + D ++ LL N
Sbjct: 122 NINAQSQNGFTPLYMAA-QENHIDVVKYLLEN 152
Score = 65.5 bits (158), Expect = 4e-11
Identities = 38/93 (40%), Positives = 51/93 (54%)
Query: 90 VRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSAC 149
V LL EK + ++ YTPLH AA + I L+ GA+ + VT G TPLH A
Sbjct: 611 VALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLAS 670
Query: 150 KWNNTRVASFLLQHDADINAQTKGLLTPLHLAA 182
+ +T + + LL A+I+ TK LT LHLAA
Sbjct: 671 QEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAA 703
Score = 63.9 bits (154), Expect = 1e-10
Identities = 44/138 (31%), Positives = 65/138 (47%), Gaps = 3/138 (2%)
Query: 81 AAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVD 140
A +KNR+ V LL + + E TP+H AA+ GHL+IV L+ GA +
Sbjct: 405 ACKKNRIK-VMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIR 463
Query: 141 GWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNRYV 200
G T LH A + V LL++ A ++A+ + TPLH+A +R K + LL+
Sbjct: 464 GETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIA--SRLGKTEIVQLLLQHMA 521
Query: 201 KPGLKNNLEETAFDIARR 218
P T I+ R
Sbjct: 522 HPDAATTNGYTPLHISAR 539
Score = 63.5 bits (153), Expect = 2e-10
Identities = 36/108 (33%), Positives = 63/108 (58%), Gaps = 5/108 (4%)
Query: 90 VRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSAC 149
V ++L ++ ++N + ++ +TPL+ AA H+D+V+ L+ GA+ T DG+TPL A
Sbjct: 112 VVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVAL 171
Query: 150 KWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMN 197
+ + + + LL++D + K L LH+AA D+K + LLL N
Sbjct: 172 QQGHNQAVAILLEND----TKGKVRLPALHIAARKDDTK-SAALLLQN 214
Score = 63.5 bits (153), Expect = 2e-10
Identities = 35/93 (37%), Positives = 54/93 (58%)
Query: 90 VRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSAC 149
V LL + V+ + TPLH A+ G+ ++V+ L+ +G + A T DG TPLH A
Sbjct: 248 VATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAA 307
Query: 150 KWNNTRVASFLLQHDADINAQTKGLLTPLHLAA 182
+ + +V LL+ A + A+TK L+PLH+AA
Sbjct: 308 RSGHDQVVELLLERGAPLLARTKNGLSPLHMAA 340
Score = 59.7 bits (143), Expect = 2e-09
Identities = 36/102 (35%), Positives = 55/102 (53%), Gaps = 1/102 (0%)
Query: 81 AAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVD 140
+A + ++ LL A H + + +TPLH AA G LD+ + L+ + A + +
Sbjct: 537 SAREGQVDVASVLLEAGAAH-SLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKN 595
Query: 141 GWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAA 182
G TPLH A ++N +VA LL+ A +A K TPLH+AA
Sbjct: 596 GLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAA 637
Score = 57.0 bits (136), Expect = 1e-08
Identities = 31/101 (30%), Positives = 63/101 (62%), Gaps = 1/101 (0%)
Query: 81 AAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVD 140
AA++ + V+ LL + + V++ + T LH A+ +G ++V+ L+ +GA+++A + +
Sbjct: 71 AAKEGHVGLVQELLG-RGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQN 129
Query: 141 GWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLA 181
G+TPL+ A + N+ V +LL++ A+ + T+ TPL +A
Sbjct: 130 GFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVA 170
Score = 51.6 bits (122), Expect = 6e-07
Identities = 44/155 (28%), Positives = 66/155 (42%), Gaps = 39/155 (25%)
Query: 78 LLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIA-------- 129
L AA++N + V+ LL E + +T ED +TPL A GH V L+
Sbjct: 134 LYMAAQENHIDVVKYLL-ENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVR 192
Query: 130 -----------------------QGADVHA------VTVDGWTPLHSACKWNNTRVASFL 160
ADV + T G+TPLH A + N VA+ L
Sbjct: 193 LPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLL 252
Query: 161 LQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLL 195
L A ++ + +TPLH+A+ R + + ++LLL
Sbjct: 253 LNRGAAVDFTARNGITPLHVAS-KRGNTNMVKLLL 286
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 75.9 bits (185), Expect = 3e-14
Identities = 51/140 (36%), Positives = 79/140 (56%), Gaps = 7/140 (5%)
Query: 81 AAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVD 140
AA+ + + V+ LL KA V+ D T LH AA+ GH + + L+ + A+ +A ++
Sbjct: 339 AAQGDHVECVKHLLQHKAP-VDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALN 397
Query: 141 GWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAA--GNRDSKDTLELLLMNR 198
G+TPLH ACK N +V L+++ A I A T+ LTP+H+AA G+ + + LLL+
Sbjct: 398 GFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLN----IVLLLLQN 453
Query: 199 YVKPGLKNNLEETAFDIARR 218
P + N ETA +A R
Sbjct: 454 GASPDVTNIRGETALHMAAR 473
Score = 70.5 bits (171), Expect = 1e-12
Identities = 39/104 (37%), Positives = 59/104 (56%)
Query: 79 LWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVT 138
L A K T + +LL ++ ++ + D TPLH AA SGH +V+ L+ +GA + A T
Sbjct: 270 LHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLART 329
Query: 139 VDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAA 182
+G +PLH A + ++ LLQH A ++ T LT LH+AA
Sbjct: 330 KNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAA 373
Score = 70.5 bits (171), Expect = 1e-12
Identities = 46/140 (32%), Positives = 70/140 (50%), Gaps = 2/140 (1%)
Query: 79 LWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVT 138
L A + T + LL +K +++ + T LH AA +++ L GAD A T
Sbjct: 666 LHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHT 725
Query: 139 VDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNR 198
G+TPL AC + N ++ +FLL+ A++NA+TK TPLH AA + + +L+
Sbjct: 726 KLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAA--QQGHTHIINVLLQH 783
Query: 199 YVKPGLKNNLEETAFDIARR 218
KP TA IA+R
Sbjct: 784 GAKPNATTANGNTALAIAKR 803
Score = 70.1 bits (170), Expect = 2e-12
Identities = 42/115 (36%), Positives = 61/115 (53%), Gaps = 2/115 (1%)
Query: 88 TTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHS 147
T + +LL + H + + YTPLH +A G +D+ L+ GA T G+TPLH
Sbjct: 510 TEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHV 569
Query: 148 ACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNRYVKP 202
A K+ + VA LLQ A ++ K LTPLH+AA + K + LLL+ + P
Sbjct: 570 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQK--VALLLLEKGASP 622
Score = 70.1 bits (170), Expect = 2e-12
Identities = 43/117 (36%), Positives = 64/117 (54%), Gaps = 1/117 (0%)
Query: 79 LWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVT 138
L A K V +LL ++ ++ ++ TPLH AA+ + + L+ +GA HA
Sbjct: 567 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 626
Query: 139 VDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLL 195
+G+TPLH A K N ++AS LL + A+ N TK +TPLHLA+ D + LLL
Sbjct: 627 KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLAS-QEGHTDMVTLLL 682
Score = 68.2 bits (165), Expect = 6e-12
Identities = 40/98 (40%), Positives = 55/98 (56%), Gaps = 2/98 (2%)
Query: 101 VNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFL 160
VN E +TPLH AA+ G++++ L+ +GA V +G TPLH A K NT + L
Sbjct: 226 VNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLL 285
Query: 161 LQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNR 198
L I+A+T+ LTPLH AA R D + LL+ R
Sbjct: 286 LDRGGQIDAKTRDGLTPLHCAA--RSGHDQVVELLLER 321
Score = 68.2 bits (165), Expect = 6e-12
Identities = 48/118 (40%), Positives = 63/118 (53%), Gaps = 2/118 (1%)
Query: 81 AAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVD 140
AA ++ VR LL A V+ R +E TPLH A+ G +IVQ L+ A A T +
Sbjct: 471 AARAGQVEVVRCLLRNGAL-VDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTN 529
Query: 141 GWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNR 198
G+TPLH + + VAS LL+ A + TK TPLH+AA S D +LLL R
Sbjct: 530 GYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAA-KYGSLDVAKLLLQRR 586
Score = 66.6 bits (161), Expect = 2e-11
Identities = 49/152 (32%), Positives = 75/152 (49%), Gaps = 4/152 (2%)
Query: 48 NSDEDEEQDDKNEEWYRLQEKKMEK--DPSRLLLWAAEKNRLTTVRRLLSEKATHVNTRD 105
N D ++ D + Q +K K D + L AA L V L + +NT +
Sbjct: 3 NEDAAQKSDSGEKFNGSSQRRKRPKKSDSNASFLRAARAGNLDKVVEYL-KGGIDINTCN 61
Query: 106 EDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDA 165
++ LH AA GH+ +VQEL+ +G+ V + T G T LH A V L++ A
Sbjct: 62 QNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGA 121
Query: 166 DINAQTKGLLTPLHLAAGNRDSKDTLELLLMN 197
+INAQ++ TPL++AA + D ++ LL N
Sbjct: 122 NINAQSQNGFTPLYMAA-QENHIDVVKYLLEN 152
Score = 65.5 bits (158), Expect = 4e-11
Identities = 38/93 (40%), Positives = 51/93 (54%)
Query: 90 VRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSAC 149
V LL EK + ++ YTPLH AA + I L+ GA+ + VT G TPLH A
Sbjct: 611 VALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLAS 670
Query: 150 KWNNTRVASFLLQHDADINAQTKGLLTPLHLAA 182
+ +T + + LL A+I+ TK LT LHLAA
Sbjct: 671 QEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAA 703
Score = 63.9 bits (154), Expect = 1e-10
Identities = 44/138 (31%), Positives = 65/138 (47%), Gaps = 3/138 (2%)
Query: 81 AAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVD 140
A +KNR+ V LL + + E TP+H AA+ GHL+IV L+ GA +
Sbjct: 405 ACKKNRIK-VMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIR 463
Query: 141 GWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNRYV 200
G T LH A + V LL++ A ++A+ + TPLH+A +R K + LL+
Sbjct: 464 GETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIA--SRLGKTEIVQLLLQHMA 521
Query: 201 KPGLKNNLEETAFDIARR 218
P T I+ R
Sbjct: 522 HPDAATTNGYTPLHISAR 539
Score = 63.5 bits (153), Expect = 2e-10
Identities = 36/108 (33%), Positives = 63/108 (58%), Gaps = 5/108 (4%)
Query: 90 VRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSAC 149
V ++L ++ ++N + ++ +TPL+ AA H+D+V+ L+ GA+ T DG+TPL A
Sbjct: 112 VVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVAL 171
Query: 150 KWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMN 197
+ + + + LL++D + K L LH+AA D+K + LLL N
Sbjct: 172 QQGHNQAVAILLEND----TKGKVRLPALHIAARKDDTK-SAALLLQN 214
Score = 63.5 bits (153), Expect = 2e-10
Identities = 35/93 (37%), Positives = 54/93 (58%)
Query: 90 VRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSAC 149
V LL + V+ + TPLH A+ G+ ++V+ L+ +G + A T DG TPLH A
Sbjct: 248 VATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAA 307
Query: 150 KWNNTRVASFLLQHDADINAQTKGLLTPLHLAA 182
+ + +V LL+ A + A+TK L+PLH+AA
Sbjct: 308 RSGHDQVVELLLERGAPLLARTKNGLSPLHMAA 340
Score = 59.7 bits (143), Expect = 2e-09
Identities = 36/102 (35%), Positives = 55/102 (53%), Gaps = 1/102 (0%)
Query: 81 AAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVD 140
+A + ++ LL A H + + +TPLH AA G LD+ + L+ + A + +
Sbjct: 537 SAREGQVDVASVLLEAGAAH-SLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKN 595
Query: 141 GWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAA 182
G TPLH A ++N +VA LL+ A +A K TPLH+AA
Sbjct: 596 GLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAA 637
Score = 57.0 bits (136), Expect = 1e-08
Identities = 31/101 (30%), Positives = 63/101 (62%), Gaps = 1/101 (0%)
Query: 81 AAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVD 140
AA++ + V+ LL + + V++ + T LH A+ +G ++V+ L+ +GA+++A + +
Sbjct: 71 AAKEGHVGLVQELLG-RGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQN 129
Query: 141 GWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLA 181
G+TPL+ A + N+ V +LL++ A+ + T+ TPL +A
Sbjct: 130 GFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVA 170
Score = 51.6 bits (122), Expect = 6e-07
Identities = 44/155 (28%), Positives = 66/155 (42%), Gaps = 39/155 (25%)
Query: 78 LLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIA-------- 129
L AA++N + V+ LL E + +T ED +TPL A GH V L+
Sbjct: 134 LYMAAQENHIDVVKYLL-ENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVR 192
Query: 130 -----------------------QGADVHA------VTVDGWTPLHSACKWNNTRVASFL 160
ADV + T G+TPLH A + N VA+ L
Sbjct: 193 LPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLL 252
Query: 161 LQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLL 195
L A ++ + +TPLH+A+ R + + ++LLL
Sbjct: 253 LNRGAAVDFTARNGITPLHVAS-KRGNTNMVKLLL 286
>gi|224465233 euchromatic histone-lysine N-methyltransferase 1
isoform 1 [Homo sapiens]
Length = 1298
Score = 74.3 bits (181), Expect = 9e-14
Identities = 42/116 (36%), Positives = 63/116 (54%), Gaps = 1/116 (0%)
Query: 78 LLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAV 137
++WA E + V+ LLS K + +N RD +E LH AA+SG +DI + L+A D+HAV
Sbjct: 877 MIWATEYKHVDLVKLLLS-KGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAV 935
Query: 138 TVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLEL 193
+ G +PLH A + N L D+D+ + K TPL A+ N L++
Sbjct: 936 NIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLNSQVWSALQM 991
Score = 60.1 bits (144), Expect = 2e-09
Identities = 44/128 (34%), Positives = 64/128 (50%), Gaps = 2/128 (1%)
Query: 69 KMEKDPSRLLLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELI 128
KME R L AA + + +L + +++T ED+ TPL AA + HL+ V+ LI
Sbjct: 767 KMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLI 826
Query: 129 AQGADVHAVTVDGWTPLHSACKWNNTRVASFLLQH-DADINAQTKGLLTPLHLAAGNRDS 187
GA V +G T LH A K + V +LL + D+N Q G TP+ + A
Sbjct: 827 KAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPM-IWATEYKH 885
Query: 188 KDTLELLL 195
D ++LLL
Sbjct: 886 VDLVKLLL 893
Score = 52.8 bits (125), Expect = 3e-07
Identities = 35/130 (26%), Positives = 63/130 (48%), Gaps = 1/130 (0%)
Query: 68 KKMEKDPSRLLLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQEL 127
KK+ P +L A + + L+ + +++ +PLH AA +GH+DI L
Sbjct: 733 KKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHML 792
Query: 128 IAQGADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDS 187
+ GA++ + D TPL A + N+ +L++ A ++ + T LHLAA +
Sbjct: 793 VQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAA-KKGH 851
Query: 188 KDTLELLLMN 197
+ ++ LL N
Sbjct: 852 YEVVQYLLSN 861
Score = 28.9 bits (63), Expect = 4.1
Identities = 24/93 (25%), Positives = 42/93 (45%), Gaps = 2/93 (2%)
Query: 112 LHRAAYSGHLDIVQELIAQGADVHAVTV--DGWTPLHSACKWNNTRVASFLLQHDADINA 169
L+ +A G L V ++ G D + + +PLH+A + + + L+Q A+I+
Sbjct: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
Query: 170 QTKGLLTPLHLAAGNRDSKDTLELLLMNRYVKP 202
++ TPL AA N + L+ V P
Sbjct: 802 CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDP 834
>gi|16975496 cortactin binding protein 2 [Homo sapiens]
Length = 1663
Score = 72.8 bits (177), Expect = 2e-13
Identities = 47/128 (36%), Positives = 73/128 (57%), Gaps = 4/128 (3%)
Query: 77 LLLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHA 136
LL AA + +T + LL+E+ +N ED ++ L+ AA +GH D V+ L++ A V+A
Sbjct: 713 LLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNA 772
Query: 137 VTVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLL- 195
+G+TPL +A + L+ +DA+IN G TPL+LA N +K+ ++LLL
Sbjct: 773 ADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKN-GNKECIKLLLE 831
Query: 196 --MNRYVK 201
NR VK
Sbjct: 832 AGTNRSVK 839
Score = 72.8 bits (177), Expect = 2e-13
Identities = 47/133 (35%), Positives = 71/133 (53%), Gaps = 1/133 (0%)
Query: 79 LWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVT 138
L++A KN T RLL VN D++ +TPL AA GH + V+ LI+ A+++
Sbjct: 748 LYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAA 807
Query: 139 VDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNR 198
G TPL+ ACK N LL+ + + +T TP+H AA + + D+L+LL+ +R
Sbjct: 808 DGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVH-AAVDTGNVDSLKLLMYHR 866
Query: 199 YVKPGLKNNLEET 211
G N EE+
Sbjct: 867 IPAHGNSFNEEES 879
Score = 35.0 bits (79), Expect = 0.058
Identities = 34/149 (22%), Positives = 68/149 (45%), Gaps = 7/149 (4%)
Query: 73 DPSRLLLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGA 132
D + L+ A KN +LL E T+ + + D +TP+H A +G++D ++ L+
Sbjct: 808 DGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRI 867
Query: 133 DVHAVTVDGWTPLHSACKWNNTR-----VASFLLQHDADINAQTKGLLTPLHLAAGNRDS 187
H + + S + ++ ++ D +A +G T H+AA ++
Sbjct: 868 PAHGNSFNEEESESSVFDLDGGEESPEGISKPVVPADLINHANREG-WTAAHIAA-SKGF 925
Query: 188 KDTLELLLMNRYVKPGLKNNLEETAFDIA 216
K+ LE+L + ++P ++ T D+A
Sbjct: 926 KNCLEILCRHGGLEPERRDKCNRTVHDVA 954
>gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]
Length = 2039
Score = 71.6 bits (174), Expect = 6e-13
Identities = 48/124 (38%), Positives = 63/124 (50%), Gaps = 6/124 (4%)
Query: 95 SEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNT 154
S + VN R+E TPLH AA G + V+ELI+ GA+V+ GWTPLH AC
Sbjct: 149 SRQKDKVNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYY 208
Query: 155 RVASFLLQHDADINAQTKGLLTPLH--LAAGNRDSKDTLELLLMNRYVKPGLKNNLEETA 212
VA L+ AD+N Q TPLH ++G+RD + LL+ P N E
Sbjct: 209 DVAKILIAAGADVNTQGLDDDTPLHDSASSGHRD----IVKLLLRHGGNPFQANKHGERP 264
Query: 213 FDIA 216
D+A
Sbjct: 265 VDVA 268
Score = 40.0 bits (92), Expect = 0.002
Identities = 22/59 (37%), Positives = 31/59 (52%)
Query: 90 VRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSA 148
V ++L VNT+ D+ TPLH +A SGH DIV+ L+ G + G P+ A
Sbjct: 210 VAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVA 268
>gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]
Length = 2062
Score = 71.6 bits (174), Expect = 6e-13
Identities = 48/124 (38%), Positives = 63/124 (50%), Gaps = 6/124 (4%)
Query: 95 SEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNT 154
S + VN R+E TPLH AA G + V+ELI+ GA+V+ GWTPLH AC
Sbjct: 172 SRQKDKVNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYY 231
Query: 155 RVASFLLQHDADINAQTKGLLTPLH--LAAGNRDSKDTLELLLMNRYVKPGLKNNLEETA 212
VA L+ AD+N Q TPLH ++G+RD + LL+ P N E
Sbjct: 232 DVAKILIAAGADVNTQGLDDDTPLHDSASSGHRD----IVKLLLRHGGNPFQANKHGERP 287
Query: 213 FDIA 216
D+A
Sbjct: 288 VDVA 291
Score = 40.0 bits (92), Expect = 0.002
Identities = 22/59 (37%), Positives = 31/59 (52%)
Query: 90 VRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSA 148
V ++L VNT+ D+ TPLH +A SGH DIV+ L+ G + G P+ A
Sbjct: 233 VAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVA 291
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 71.2 bits (173), Expect = 7e-13
Identities = 46/125 (36%), Positives = 63/125 (50%), Gaps = 2/125 (1%)
Query: 92 RLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKW 151
RLL V+ + YTPL AA D+ L+A GAD + V DGW PLH A +
Sbjct: 379 RLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQN 438
Query: 152 NNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNRYVKPGLKNNLEET 211
+ A LL H A ++AQ + TPLHLAA N + + + LL++R P L +T
Sbjct: 439 GDDGTARLLLDHGACVDAQEREGWTPLHLAAQN--NFENVARLLVSRQADPNLHEAEGKT 496
Query: 212 AFDIA 216
+A
Sbjct: 497 PLHVA 501
Score = 66.6 bits (161), Expect = 2e-11
Identities = 37/86 (43%), Positives = 46/86 (53%)
Query: 109 YTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADIN 168
+TPLH AAY GHL+I+ L A++ A+ WTPLH A + V S LLQ AD N
Sbjct: 594 WTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPN 653
Query: 169 AQTKGLLTPLHLAAGNRDSKDTLELL 194
A + TPLHLA + LL
Sbjct: 654 AAEQSGWTPLHLAVQRSTFLSVINLL 679
Score = 63.5 bits (153), Expect = 2e-10
Identities = 39/102 (38%), Positives = 54/102 (52%), Gaps = 1/102 (0%)
Query: 81 AAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVD 140
AA K L + LL+E ++ +TPLH AA G +V L+ GAD +A
Sbjct: 600 AAYKGHLEIIH-LLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQS 658
Query: 141 GWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAA 182
GWTPLH A + + LL+H A+++A+ K TP HLAA
Sbjct: 659 GWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAA 700
Score = 61.2 bits (147), Expect = 7e-10
Identities = 42/105 (40%), Positives = 53/105 (50%), Gaps = 1/105 (0%)
Query: 78 LLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAV 137
LL AA+ + LL+ A N DED + PLH AA +G + L+ GA V A
Sbjct: 399 LLIAAQDQQPDLCALLLAHGAD-ANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQ 457
Query: 138 TVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAA 182
+GWTPLH A + N VA L+ AD N TPLH+AA
Sbjct: 458 EREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAA 502
Score = 61.2 bits (147), Expect = 7e-10
Identities = 36/113 (31%), Positives = 63/113 (55%), Gaps = 1/113 (0%)
Query: 69 KMEKDPSRLLLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELI 128
++++D L +AA+ T R LL A V+ ++ + +TPLH AA + ++ + L+
Sbjct: 423 RVDEDGWAPLHFAAQNGDDGTARLLLDHGAC-VDAQEREGWTPLHLAAQNNFENVARLLV 481
Query: 129 AQGADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLA 181
++ AD + +G TPLH A + + + L A+++AQ + L TPLHLA
Sbjct: 482 SRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLA 534
Score = 60.5 bits (145), Expect = 1e-09
Identities = 38/104 (36%), Positives = 53/104 (50%)
Query: 79 LWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVT 138
L A +N V RLL + N + + TPLH AAY GH+ +V+ L +QGA++ A
Sbjct: 465 LHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQ 524
Query: 139 VDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAA 182
+ TPLH A + R LL+ A +A + PLH AA
Sbjct: 525 RNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAA 568
Score = 53.9 bits (128), Expect = 1e-07
Identities = 44/136 (32%), Positives = 64/136 (47%), Gaps = 9/136 (6%)
Query: 66 QEKKMEKDPSRLLLWAAEKNRLTTVRRLLSEKATHVNTRDED------EYTPLHRAAYSG 119
Q ++ +D S+ L+ + N L +L K ++ RDE+ + TPLH G
Sbjct: 316 QPGEVNEDISQELMDSDSGNYLKRALQLSDRK--NLVPRDEELCIYENKVTPLHFLVAQG 373
Query: 120 HLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLH 179
++ V+ L+A DV T G+TPL A + + + LL H AD N + PLH
Sbjct: 374 SVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLH 433
Query: 180 LAAGNRDSKDTLELLL 195
AA N D T LLL
Sbjct: 434 FAAQNGDD-GTARLLL 448
Score = 50.8 bits (120), Expect = 1e-06
Identities = 29/84 (34%), Positives = 40/84 (47%)
Query: 102 NTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFLL 161
N ++ +TPLH A V L+ A+VHA GWTP H A NT + L+
Sbjct: 653 NAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLV 712
Query: 162 QHDADINAQTKGLLTPLHLAAGNR 185
+ A ++ Q TPL LA +R
Sbjct: 713 EAGAQLDVQDGVSCTPLQLALRSR 736
Score = 36.6 bits (83), Expect = 0.020
Identities = 24/80 (30%), Positives = 40/80 (50%), Gaps = 1/80 (1%)
Query: 81 AAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVD 140
A +++ +V LL A +V+ R++ +TP H AA G+ I++ L+ GA +
Sbjct: 666 AVQRSTFLSVINLLEHHA-NVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGV 724
Query: 141 GWTPLHSACKWNNTRVASFL 160
TPL A + + SFL
Sbjct: 725 SCTPLQLALRSRKQGIMSFL 744
>gi|56676397 ankyrin repeat domain 11 [Homo sapiens]
Length = 2663
Score = 70.9 bits (172), Expect = 9e-13
Identities = 56/147 (38%), Positives = 74/147 (50%), Gaps = 8/147 (5%)
Query: 95 SEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNT 154
S+ VN R+E T LHRAA G ++ELI++GADV+ GWT LH AC
Sbjct: 155 SKTKDKVNKRNERGETRLHRAAIRGDARRIKELISEGADVNVKDFAGWTALHEACNRGYY 214
Query: 155 RVASFLLQHDADINAQTKGL--LTPLHLAAGNRDSKDTLELLLMNRYVKPGLKNNLEETA 212
VA LL A++N TKGL TPLH AA N K + LL+ P N ET
Sbjct: 215 DVAKQLLAAGAEVN--TKGLDDDTPLHDAANNGHYK--VVKLLLRYGGNPQQSNRKGETP 270
Query: 213 FDIARRTSIYHYLFEIVEGCTNSSPQS 239
+A ++ + L + +G SS +S
Sbjct: 271 LKVANSPTMVNLL--LGKGTYTSSEES 295
Score = 57.0 bits (136), Expect = 1e-08
Identities = 37/114 (32%), Positives = 61/114 (53%), Gaps = 2/114 (1%)
Query: 68 KKMEKDPSRLLLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQEL 127
K+ E+ +RL AA + ++ L+SE A VN +D +T LH A G+ D+ ++L
Sbjct: 163 KRNERGETRLHR-AAIRGDARRIKELISEGAD-VNVKDFAGWTALHEACNRGYYDVAKQL 220
Query: 128 IAQGADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLA 181
+A GA+V+ +D TPLH A + +V LL++ + + TPL +A
Sbjct: 221 LAAGAEVNTKGLDDDTPLHDAANNGHYKVVKLLLRYGGNPQQSNRKGETPLKVA 274
>gi|156142199 euchromatic histone-lysine N-methyltransferase 2
isoform b [Homo sapiens]
Length = 1176
Score = 70.1 bits (170), Expect = 2e-12
Identities = 50/150 (33%), Positives = 75/150 (50%), Gaps = 2/150 (1%)
Query: 71 EKDPSRLLLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQ 130
E+D S L AA+ L V LLS VN +D +TP+ AA H+++++ L+ +
Sbjct: 714 EEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 773
Query: 131 GADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDT 190
GADV + LH A + +A LL D++A TPLH+AA R+S
Sbjct: 774 GADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAA--RESYHD 831
Query: 191 LELLLMNRYVKPGLKNNLEETAFDIARRTS 220
LL ++R P L+N +TA+D+ S
Sbjct: 832 CVLLFLSRGANPELRNKEGDTAWDLTPERS 861
Score = 59.7 bits (143), Expect = 2e-09
Identities = 35/116 (30%), Positives = 59/116 (50%), Gaps = 1/116 (0%)
Query: 71 EKDPSRLLLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQ 130
++ R L AA + + +L + ++N D+ + TPL A + HL++ + ++ +
Sbjct: 647 DQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQR 706
Query: 131 GADVHAVTVDGWTPLHSACKWNNTRVASFLLQ-HDADINAQTKGLLTPLHLAAGNR 185
G V++ DG T LH A K N + S LL D+NAQ G TP+ AA ++
Sbjct: 707 GGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHK 762
Score = 51.2 bits (121), Expect = 8e-07
Identities = 33/117 (28%), Positives = 56/117 (47%)
Query: 66 QEKKMEKDPSRLLLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQ 125
+ KK+ P +L L + + LL + + + + TPLH AA G ++I
Sbjct: 609 RRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICH 668
Query: 126 ELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAA 182
L+ GA+++AV TPL A N+ VA +++Q + ++ + T LH AA
Sbjct: 669 VLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAA 725
>gi|156142197 euchromatic histone-lysine N-methyltransferase 2
isoform a [Homo sapiens]
Length = 1210
Score = 70.1 bits (170), Expect = 2e-12
Identities = 50/150 (33%), Positives = 75/150 (50%), Gaps = 2/150 (1%)
Query: 71 EKDPSRLLLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQ 130
E+D S L AA+ L V LLS VN +D +TP+ AA H+++++ L+ +
Sbjct: 748 EEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 807
Query: 131 GADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDT 190
GADV + LH A + +A LL D++A TPLH+AA R+S
Sbjct: 808 GADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAA--RESYHD 865
Query: 191 LELLLMNRYVKPGLKNNLEETAFDIARRTS 220
LL ++R P L+N +TA+D+ S
Sbjct: 866 CVLLFLSRGANPELRNKEGDTAWDLTPERS 895
Score = 59.7 bits (143), Expect = 2e-09
Identities = 35/116 (30%), Positives = 59/116 (50%), Gaps = 1/116 (0%)
Query: 71 EKDPSRLLLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQ 130
++ R L AA + + +L + ++N D+ + TPL A + HL++ + ++ +
Sbjct: 681 DQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQR 740
Query: 131 GADVHAVTVDGWTPLHSACKWNNTRVASFLLQ-HDADINAQTKGLLTPLHLAAGNR 185
G V++ DG T LH A K N + S LL D+NAQ G TP+ AA ++
Sbjct: 741 GGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHK 796
Score = 51.2 bits (121), Expect = 8e-07
Identities = 33/117 (28%), Positives = 56/117 (47%)
Query: 66 QEKKMEKDPSRLLLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQ 125
+ KK+ P +L L + + LL + + + + TPLH AA G ++I
Sbjct: 643 RRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICH 702
Query: 126 ELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAA 182
L+ GA+++AV TPL A N+ VA +++Q + ++ + T LH AA
Sbjct: 703 VLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAA 759
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 68.9 bits (167), Expect = 4e-12
Identities = 39/92 (42%), Positives = 56/92 (60%), Gaps = 1/92 (1%)
Query: 92 RLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQ-GADVHAVTVDGWTPLHSACK 150
R+L + V+ + +D + PLH AA+ GHL IV+ L Q G V+A T+DG TPLH A +
Sbjct: 554 RILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQ 613
Query: 151 WNNTRVASFLLQHDADINAQTKGLLTPLHLAA 182
+ RVA L+ +D+N + TPLH+AA
Sbjct: 614 RGHYRVARILIDLCSDVNVCSLLAQTPLHVAA 645
Score = 67.8 bits (164), Expect = 8e-12
Identities = 37/104 (35%), Positives = 55/104 (52%)
Query: 79 LWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVT 138
L A + R+ V LL + VN +DED++T LH AA +G + L+ + A V+ V
Sbjct: 475 LHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVD 534
Query: 139 VDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAA 182
+G TP+H AC+ + LL+ D++ Q K PLH AA
Sbjct: 535 FEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAA 578
Score = 63.2 bits (152), Expect = 2e-10
Identities = 42/113 (37%), Positives = 55/113 (48%)
Query: 72 KDPSRLLLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQG 131
KD L +AA + L V+ L + VN + D TPLH AA GH + + LI
Sbjct: 568 KDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLC 627
Query: 132 ADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGN 184
+DV+ ++ TPLH A + +T A LL A A T T LHLAA N
Sbjct: 628 SDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARN 680
Score = 58.9 bits (141), Expect = 4e-09
Identities = 37/105 (35%), Positives = 55/105 (52%)
Query: 90 VRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSAC 149
V R+L + + VN TPLH AA +GH + L+ +GA A+T DG+T LH A
Sbjct: 619 VARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAA 678
Query: 150 KWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELL 194
+ + L++ AD+ A+ T LHLAA + S+ EL+
Sbjct: 679 RNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELV 723
Score = 50.4 bits (119), Expect = 1e-06
Identities = 45/135 (33%), Positives = 63/135 (46%), Gaps = 7/135 (5%)
Query: 79 LWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVT 138
L A + T+ RLL + D YT LH AA +GHL V+ L+ + ADV A
Sbjct: 641 LHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARG 700
Query: 139 VDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNR 198
T LH A ++ V L+ D I+ + L+ LHLAA R ++ T+E LL
Sbjct: 701 PLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQ-TVETLL--- 755
Query: 199 YVKPGLKNNLEETAF 213
+ G NL+ F
Sbjct: 756 --RHGAHINLQSLKF 768
Score = 50.4 bits (119), Expect = 1e-06
Identities = 35/105 (33%), Positives = 51/105 (48%), Gaps = 2/105 (1%)
Query: 67 EKKMEKDPSRLLLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQE 126
++ M D L AA L TV+ L+ EKA V R T LH AA GH ++V+E
Sbjct: 663 KEAMTSDGYTALHLAARNGHLATVKLLVEEKA-DVLARGPLNQTALHLAAAHGHSEVVEE 721
Query: 127 LIAQGADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQT 171
L++ + G + LH A + + + LL+H A IN Q+
Sbjct: 722 LVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQS 765
Score = 43.5 bits (101), Expect = 2e-04
Identities = 36/129 (27%), Positives = 59/129 (45%), Gaps = 3/129 (2%)
Query: 77 LLLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHA 136
LL A E + + LL A + N + TPLH A +V+ L+A+ V+A
Sbjct: 441 LLHLAVEAGQEECAKWLLLNNA-NPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNA 499
Query: 137 VTVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLM 196
D WT LH A + + LL+ +A +N TP+H+A + ++ + +L+
Sbjct: 500 KDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVAC--QHGQENIVRILL 557
Query: 197 NRYVKPGLK 205
R V L+
Sbjct: 558 RRGVDVSLQ 566
Score = 33.1 bits (74), Expect = 0.22
Identities = 28/89 (31%), Positives = 41/89 (46%), Gaps = 2/89 (2%)
Query: 128 IAQGADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDS 187
I Q DV G + LH A + A +LL ++A+ N + TPLH+A R
Sbjct: 425 ILQPQDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAV-ERRV 483
Query: 188 KDTLELLLMNRYVKPGLKNNLEETAFDIA 216
+ +ELLL R + K+ + TA A
Sbjct: 484 RGVVELLLA-RKISVNAKDEDQWTALHFA 511
>gi|103471993 huntingtin interacting protein 14 [Homo sapiens]
Length = 632
Score = 68.6 bits (166), Expect = 5e-12
Identities = 40/128 (31%), Positives = 67/128 (52%)
Query: 68 KKMEKDPSRLLLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQEL 127
++ +K+ LL WAA NR+ V+ +S+ A + TPLH A GHL +V +L
Sbjct: 84 RQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMVVQL 143
Query: 128 IAQGADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDS 187
+ GAD + +G + +H A ++ +T + ++L+ D++ + +TPL AA S
Sbjct: 144 MKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMWAAYRTHS 203
Query: 188 KDTLELLL 195
D LLL
Sbjct: 204 VDPTRLLL 211
Score = 37.0 bits (84), Expect = 0.015
Identities = 33/127 (25%), Positives = 56/127 (44%), Gaps = 6/127 (4%)
Query: 70 MEKDPSRLLLWAAEKNRLTTVRRLLSEKATHVNTRDE-DEYTPLHRAAYSGHLDIVQELI 128
M+++ L+WAA + RLL VN D+ + T LH A +G+ ++ L+
Sbjct: 186 MDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVISLLL 245
Query: 129 AQGADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSK 188
GA+V A + G + L A + N + + L + Q KG P L D +
Sbjct: 246 EAGANVDAQNIKGESALDLAKQRKNVWMINHLQE-----ARQAKGYDNPSFLRKLKADKE 300
Query: 189 DTLELLL 195
+++L
Sbjct: 301 FRQKVML 307
>gi|62420875 integrin-linked kinase [Homo sapiens]
Length = 452
Score = 68.2 bits (165), Expect = 6e-12
Identities = 53/164 (32%), Positives = 72/164 (43%), Gaps = 21/164 (12%)
Query: 44 LWVGNSDEDEEQDDKNEEWYRLQEKKMEKDPSRLLLWAAEKNRLTTVRRLLSEKATHVNT 103
LW+ N++ D Q D + L WA + R V L+ A +N
Sbjct: 18 LWLDNTENDLNQGDDHG--------------FSPLHWACREGRSAVVEMLIMRGA-RINV 62
Query: 104 RDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFLLQH 163
+ + TPLH AA GH DIVQ+L+ AD++AV G PLH AC W +VA L+ +
Sbjct: 63 MNRGDDTPLHLAASHGHRDIVQKLLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLVAN 122
Query: 164 DADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNRYVKPGLKNN 207
A ++ K P+ A K L LL R K G N
Sbjct: 123 GALVSICNKYGEMPVDKA------KAPLRELLRERAEKMGQNLN 160
Score = 54.7 bits (130), Expect = 7e-08
Identities = 32/92 (34%), Positives = 46/92 (50%)
Query: 90 VRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSAC 149
VR L +N D+ ++PLH A G +V+ LI +GA ++ + TPLH A
Sbjct: 16 VRLWLDNTENDLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDTPLHLAA 75
Query: 150 KWNNTRVASFLLQHDADINAQTKGLLTPLHLA 181
+ + LLQ+ ADINA + PLH A
Sbjct: 76 SHGHRDIVQKLLQYKADINAVNEHGNVPLHYA 107
>gi|62420873 integrin-linked kinase [Homo sapiens]
Length = 452
Score = 68.2 bits (165), Expect = 6e-12
Identities = 53/164 (32%), Positives = 72/164 (43%), Gaps = 21/164 (12%)
Query: 44 LWVGNSDEDEEQDDKNEEWYRLQEKKMEKDPSRLLLWAAEKNRLTTVRRLLSEKATHVNT 103
LW+ N++ D Q D + L WA + R V L+ A +N
Sbjct: 18 LWLDNTENDLNQGDDHG--------------FSPLHWACREGRSAVVEMLIMRGA-RINV 62
Query: 104 RDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFLLQH 163
+ + TPLH AA GH DIVQ+L+ AD++AV G PLH AC W +VA L+ +
Sbjct: 63 MNRGDDTPLHLAASHGHRDIVQKLLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLVAN 122
Query: 164 DADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNRYVKPGLKNN 207
A ++ K P+ A K L LL R K G N
Sbjct: 123 GALVSICNKYGEMPVDKA------KAPLRELLRERAEKMGQNLN 160
Score = 54.7 bits (130), Expect = 7e-08
Identities = 32/92 (34%), Positives = 46/92 (50%)
Query: 90 VRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSAC 149
VR L +N D+ ++PLH A G +V+ LI +GA ++ + TPLH A
Sbjct: 16 VRLWLDNTENDLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDTPLHLAA 75
Query: 150 KWNNTRVASFLLQHDADINAQTKGLLTPLHLA 181
+ + LLQ+ ADINA + PLH A
Sbjct: 76 SHGHRDIVQKLLQYKADINAVNEHGNVPLHYA 107
>gi|4758606 integrin-linked kinase [Homo sapiens]
Length = 452
Score = 68.2 bits (165), Expect = 6e-12
Identities = 53/164 (32%), Positives = 72/164 (43%), Gaps = 21/164 (12%)
Query: 44 LWVGNSDEDEEQDDKNEEWYRLQEKKMEKDPSRLLLWAAEKNRLTTVRRLLSEKATHVNT 103
LW+ N++ D Q D + L WA + R V L+ A +N
Sbjct: 18 LWLDNTENDLNQGDDHG--------------FSPLHWACREGRSAVVEMLIMRGA-RINV 62
Query: 104 RDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFLLQH 163
+ + TPLH AA GH DIVQ+L+ AD++AV G PLH AC W +VA L+ +
Sbjct: 63 MNRGDDTPLHLAASHGHRDIVQKLLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLVAN 122
Query: 164 DADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNRYVKPGLKNN 207
A ++ K P+ A K L LL R K G N
Sbjct: 123 GALVSICNKYGEMPVDKA------KAPLRELLRERAEKMGQNLN 160
Score = 54.7 bits (130), Expect = 7e-08
Identities = 32/92 (34%), Positives = 46/92 (50%)
Query: 90 VRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSAC 149
VR L +N D+ ++PLH A G +V+ LI +GA ++ + TPLH A
Sbjct: 16 VRLWLDNTENDLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDTPLHLAA 75
Query: 150 KWNNTRVASFLLQHDADINAQTKGLLTPLHLA 181
+ + LLQ+ ADINA + PLH A
Sbjct: 76 SHGHRDIVQKLLQYKADINAVNEHGNVPLHYA 107
>gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo
sapiens]
Length = 226
Score = 67.4 bits (163), Expect = 1e-11
Identities = 46/143 (32%), Positives = 75/143 (52%), Gaps = 7/143 (4%)
Query: 69 KMEKDPSRLLLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELI 128
+ ++D L WA V LL + VN +D+ ++PLH AA +G +IV+ L+
Sbjct: 35 RTDQDSRTALHWACSAGHTEIVEFLL-QLGVPVNDKDDAGWSPLHIAASAGRDEIVKALL 93
Query: 129 AQGADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSK 188
+GA V+AV +G TPLH A N +A LL+ A+ +A+ T +H AA +K
Sbjct: 94 GKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA----AK 149
Query: 189 DTLELLLMNRYVKPGLKNNLEET 211
L+++ + Y K N+++T
Sbjct: 150 GNLKMIHILLYYK--ASTNIQDT 170
Score = 57.0 bits (136), Expect = 1e-08
Identities = 36/106 (33%), Positives = 52/106 (49%), Gaps = 1/106 (0%)
Query: 78 LLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAV 137
L +AA KNR + +L E + + +D E T +HRAA G+L ++ L+ A +
Sbjct: 110 LHYAASKNR-HEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQ 168
Query: 138 TVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAG 183
+G TPLH AC A L+ A I + K TPL +A G
Sbjct: 169 DTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAKG 214
Score = 50.1 bits (118), Expect = 2e-06
Identities = 41/137 (29%), Positives = 62/137 (45%), Gaps = 3/137 (2%)
Query: 81 AAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVD 140
AA R V+ LL K VN +++ TPLH AA +I L+ GA+ A
Sbjct: 80 AASAGRDEIVKALLG-KGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHY 138
Query: 141 GWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNRYV 200
T +H A N ++ LL + A N Q TPLHLA ++ LL+++
Sbjct: 139 EATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEA--KLLVSQGA 196
Query: 201 KPGLKNNLEETAFDIAR 217
++N E+T +A+
Sbjct: 197 SIYIENKEEKTPLQVAK 213
Score = 41.6 bits (96), Expect = 6e-04
Identities = 33/120 (27%), Positives = 52/120 (43%), Gaps = 3/120 (2%)
Query: 116 AYSGHLDIVQELIAQGADVHAVT-VDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGL 174
AYSG L+ ++E I + T D T LH AC +T + FLLQ +N +
Sbjct: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
Query: 175 LTPLHLAAGNRDSKDTLELLLMNRYVKPGLKNNLEETAFDIARRTSIYHYLFEIVEGCTN 234
+PLH+AA +D + L+ + + N T A + + ++EG N
Sbjct: 74 WSPLHIAAS--AGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGAN 131
>gi|55742857 ankyrin repeat domain 6 [Homo sapiens]
Length = 722
Score = 67.0 bits (162), Expect = 1e-11
Identities = 47/138 (34%), Positives = 70/138 (50%), Gaps = 3/138 (2%)
Query: 81 AAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVD 140
AA K L V+ LL + ++ +D+ + T LHRA G+ +I+ LI +G + D
Sbjct: 49 AANKGHLPVVQILL-KAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKD 107
Query: 141 GWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNRYV 200
G T LH A ++ A L++ A++ A+ K T LHLA N S+ T LLL
Sbjct: 108 GNTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGS-- 165
Query: 201 KPGLKNNLEETAFDIARR 218
+ LKNN +T +A R
Sbjct: 166 RADLKNNAGDTCLHVAAR 183
Score = 43.1 bits (100), Expect = 2e-04
Identities = 32/103 (31%), Positives = 45/103 (43%)
Query: 79 LWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVT 138
L A +N + R+L + + ++ T LH AA HL I++ L+ VH
Sbjct: 145 LHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKN 204
Query: 139 VDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLA 181
G T LH A N+ +VA LL+ AD TPL A
Sbjct: 205 QAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETA 247
Score = 41.6 bits (96), Expect = 6e-04
Identities = 29/80 (36%), Positives = 41/80 (51%), Gaps = 1/80 (1%)
Query: 81 AAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVD 140
AA N L+ +R LL+ + V+ +++ T LH AA H + + L+ GAD V
Sbjct: 181 AARYNHLSIIRLLLTAFCS-VHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNA 239
Query: 141 GWTPLHSACKWNNTRVASFL 160
G TPL +A NN VA L
Sbjct: 240 GQTPLETARYHNNPEVALLL 259
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.130 0.386
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,538,706
Number of Sequences: 37866
Number of extensions: 422776
Number of successful extensions: 3759
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 336
Number of HSP's successfully gapped in prelim test: 67
Number of HSP's that attempted gapping in prelim test: 1606
Number of HSP's gapped (non-prelim): 1584
length of query: 239
length of database: 18,247,518
effective HSP length: 99
effective length of query: 140
effective length of database: 14,498,784
effective search space: 2029829760
effective search space used: 2029829760
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.