Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 41327754
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
(784 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 1569 0.0
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 419 e-117
gi|4506537 receptor-interacting serine-threonine kinase 2 [Homo ... 200 4e-51
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 192 1e-48
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 191 2e-48
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 191 2e-48
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 191 2e-48
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 191 2e-48
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 191 2e-48
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 182 1e-45
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 179 7e-45
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 179 7e-45
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 179 7e-45
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 172 1e-42
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 167 3e-41
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 167 3e-41
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 166 1e-40
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 161 2e-39
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ... 159 7e-39
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ... 158 2e-38
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 158 2e-38
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 158 2e-38
gi|40254844 receptor-interacting serine-threonine kinase 3 [Homo... 151 2e-36
gi|89363047 death-associated protein kinase 1 [Homo sapiens] 150 6e-36
gi|34304381 inversin isoform a [Homo sapiens] 145 2e-34
gi|34304379 inversin isoform b [Homo sapiens] 145 2e-34
gi|96975023 ankyrin repeat and death domain containing 1A [Homo ... 143 7e-34
gi|223634006 hypothetical protein LOC441869 [Homo sapiens] 142 2e-33
gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens] 137 4e-32
gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens] 137 4e-32
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 1569 bits (4063), Expect = 0.0
Identities = 784/784 (100%), Positives = 784/784 (100%)
Query: 1 MEGDGGTPWALALLRTFDAGEFTGWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDD 60
MEGDGGTPWALALLRTFDAGEFTGWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDD
Sbjct: 1 MEGDGGTPWALALLRTFDAGEFTGWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDD 60
Query: 61 RERMELLEEAKKMEMAKFRYILPVYGICREPVGLVMEYMETGSLEKLLASEPLPWDLRFR 120
RERMELLEEAKKMEMAKFRYILPVYGICREPVGLVMEYMETGSLEKLLASEPLPWDLRFR
Sbjct: 61 RERMELLEEAKKMEMAKFRYILPVYGICREPVGLVMEYMETGSLEKLLASEPLPWDLRFR 120
Query: 121 IIHETAVGMNFLHCMAPPLLHLDLKPANILLDAHYHVKISDFGLAKCNGLSHSHDLSMDG 180
IIHETAVGMNFLHCMAPPLLHLDLKPANILLDAHYHVKISDFGLAKCNGLSHSHDLSMDG
Sbjct: 121 IIHETAVGMNFLHCMAPPLLHLDLKPANILLDAHYHVKISDFGLAKCNGLSHSHDLSMDG 180
Query: 181 LFGTIAYLPPERIREKSRLFDTKHDVYSFAIVIWGVLTQKKPFADEKNILHIMVKVVKGH 240
LFGTIAYLPPERIREKSRLFDTKHDVYSFAIVIWGVLTQKKPFADEKNILHIMVKVVKGH
Sbjct: 181 LFGTIAYLPPERIREKSRLFDTKHDVYSFAIVIWGVLTQKKPFADEKNILHIMVKVVKGH 240
Query: 241 RPELPPVCRARPRACSHLIRLMQRCWQGDPRVRPTFQEITSETEDLCEKPDDEVKETAHD 300
RPELPPVCRARPRACSHLIRLMQRCWQGDPRVRPTFQEITSETEDLCEKPDDEVKETAHD
Sbjct: 241 RPELPPVCRARPRACSHLIRLMQRCWQGDPRVRPTFQEITSETEDLCEKPDDEVKETAHD 300
Query: 301 LDVKSPPEPRSEVVPARLKRASAPTFDNDYSLSELLSQLDSGVSQAVEGPEELSRSSSES 360
LDVKSPPEPRSEVVPARLKRASAPTFDNDYSLSELLSQLDSGVSQAVEGPEELSRSSSES
Sbjct: 301 LDVKSPPEPRSEVVPARLKRASAPTFDNDYSLSELLSQLDSGVSQAVEGPEELSRSSSES 360
Query: 361 KLPSSGSGKRLSGVSSVDSAFSSRGSLSLSFEREPSTSDLGTTDVQKKKLVDAIVSGDTS 420
KLPSSGSGKRLSGVSSVDSAFSSRGSLSLSFEREPSTSDLGTTDVQKKKLVDAIVSGDTS
Sbjct: 361 KLPSSGSGKRLSGVSSVDSAFSSRGSLSLSFEREPSTSDLGTTDVQKKKLVDAIVSGDTS 420
Query: 421 KLMKILQPQDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVE 480
KLMKILQPQDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVE
Sbjct: 421 KLMKILQPQDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVE 480
Query: 481 RRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTP 540
RRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTP
Sbjct: 481 RRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTP 540
Query: 541 MHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQ 600
MHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQ
Sbjct: 541 MHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQ 600
Query: 601 TLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRG 660
TLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRG
Sbjct: 601 TLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRG 660
Query: 661 AGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVE 720
AGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVE
Sbjct: 661 AGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVE 720
Query: 721 ELVSADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSLKFQGGHGPAATLLR 780
ELVSADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSLKFQGGHGPAATLLR
Sbjct: 721 ELVSADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSLKFQGGHGPAATLLR 780
Query: 781 RSKT 784
RSKT
Sbjct: 781 RSKT 784
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 419 bits (1076), Expect = e-117
Identities = 279/765 (36%), Positives = 394/765 (51%), Gaps = 87/765 (11%)
Query: 7 TPWALALLRTFDAGEFTG-WEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVD--DRER 63
T L L F +F G W V SGGF QV++ RH W+T AIKC+P L D +
Sbjct: 6 TELRLGSLPVFTRDDFEGDWRLVASGGFSQVFQARHRRWRTEYAIKCAPCLPPDAASSDV 65
Query: 64 MELLEEAKKMEMAKFRYILPVYGICREPVGLVMEYMETGSLEKLLASEPLPWDLRFRIIH 123
L+EEA KM+ KF++I+ +YG+C++P+G+VME+M GSLEK+L++ L W LRFRIIH
Sbjct: 66 NYLIEEAAKMKKIKFQHIVSIYGVCKQPLGIVMEFMANGSLEKVLSTHSLCWKLRFRIIH 125
Query: 124 ETAVGMNFLHCMAPPLLHLDLKPANILLDAHYHVKISDFGLAKCNGLS-HSHDLSMDGLF 182
ET++ MNFLH + PPLLHLDLKP NILLD++ HVKISDFGL+K S + L
Sbjct: 126 ETSLAMNFLHSIKPPLLHLDLKPGNILLDSNMHVKISDFGLSKWMEQSTRMQYIERSALR 185
Query: 183 GTIAYLPPERIREKSRLFDTKHDVYSFAIVIWGVLTQKKPFADEKNILHIMVKVVKGHRP 242
G ++Y+PPE E ++ K+DVYSFAIVIW +LTQKKP++ N++ I+++V G R
Sbjct: 186 GMLSYIPPEMFLESNKAPGPKYDVYSFAIVIWELLTQKKPYSGF-NMMMIIIRVAAGMR- 243
Query: 243 ELPPVCRARPRACSHLIRLMQRCWQGDPRVRPTFQEITSETEDLCEKPDDEVKETAHDLD 302
P ++P + SE + + + + + D D
Sbjct: 244 ---------------------------PSLQPVSDQWPSEAQQMVD-----LMKRCWDQD 271
Query: 303 VKSPPEPRSEVVPARLKRASAPTFDNDYSLSELLSQLDSGVSQAVEGPEELSRSSSESKL 362
K P D LLS L S V+ +
Sbjct: 272 PKKRP----------------CFLDITIETDILLSLLQSRVA-----------------V 298
Query: 363 PSSGSGKRLSGVSSVDSAFSSRGSLSLSFEREPSTSDLGTTDVQKKKLVDAIVSGDTSKL 422
P S K L+ S + G ++ +E SD G + +L D
Sbjct: 299 PES---KALARKVSCKLSLRQPGEVNEDISQELMDSDSGNYLKRALQLSDR--------- 346
Query: 423 MKILQPQDVDLAL-DSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVER 481
K L P+D +L + ++ + LH V G E + LL + + + G TPL +A +
Sbjct: 347 -KNLVPRDEELCIYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQD 405
Query: 482 RVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPM 541
+ + LLLA N DED W LHFAAQNGD+ + RLLL+ A V+ + EG TP+
Sbjct: 406 QQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPL 465
Query: 542 HVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQT 601
H+A Q+ EN+ R+L+ R D +L + PLH AA+ GH+ +VKLL Q G ++AQ
Sbjct: 466 HLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQ-GAELDAQQ 524
Query: 602 LDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGA 661
+ RTPLHLA +RG R + L+ + + PLH AA G ++LL GA
Sbjct: 525 RNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGA 584
Query: 662 GKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEE 721
E T G+T LHLAA GHL + LL E A++ A G +N T LHLAA HG VV
Sbjct: 585 SLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSA 644
Query: 722 LVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQS 765
L+ + ++ G + LHLA Q +V LL H A+++ ++
Sbjct: 645 LLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARN 689
Score = 96.3 bits (238), Expect = 1e-19
Identities = 71/220 (32%), Positives = 103/220 (46%), Gaps = 6/220 (2%)
Query: 397 TSDLGTTDVQKKKLVD----AIVSGDTSKLMKILQPQDVDLALD-SGASLLHLAVEAGQE 451
TS D Q++ L A+ G + +L+ V ALD SG LH A G+
Sbjct: 514 TSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKY 573
Query: 452 ECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFA 511
K LL A+ L +G TPLH+A + ++ LL ++ A WT LH A
Sbjct: 574 LICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLA 633
Query: 512 AQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAW 571
A++G+E+ LL+ A N + G TP+H+A Q V LL +V + K W
Sbjct: 634 ARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGW 693
Query: 572 LPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLA 611
P H AA +G+ I+K+L + G ++ Q TPL LA
Sbjct: 694 TPAHLAALKGNTAILKVLV-EAGAQLDVQDGVSCTPLQLA 732
Score = 68.2 bits (165), Expect = 3e-11
Identities = 41/126 (32%), Positives = 67/126 (53%)
Query: 442 LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKD 501
LHLA G+E LL A+PN + + G TPLH+AV+R V LL +V+A++
Sbjct: 630 LHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARN 689
Query: 502 EDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGV 561
+ WT H AA G+ + ++L+E A ++ D TP+ +A + ++ I+ L +
Sbjct: 690 KVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFLEGKEP 749
Query: 562 DVSLQG 567
V+ G
Sbjct: 750 SVATLG 755
>gi|4506537 receptor-interacting serine-threonine kinase 2 [Homo
sapiens]
Length = 540
Score = 200 bits (509), Expect = 4e-51
Identities = 121/273 (44%), Positives = 160/273 (58%), Gaps = 27/273 (9%)
Query: 31 GGFGQVYKVRHVHWKTWLAIKCSPSLHVD----DRERMELLEEAKKMEMAKFRYILPVYG 86
G G V RH W+ +A+K LH+ D ER ++L EA+ + A+F YILP+ G
Sbjct: 27 GASGTVSSARHADWRVQVAVK---HLHIHTPLLDSERKDVLREAEILHKARFSYILPILG 83
Query: 87 ICREP--VGLVMEYMETGSLEKLLASEP----LPWDLRFRIIHETAVGMNFLHCMAPPLL 140
IC EP +G+V EYM GSL +LL + + W LRFRI+HE A+G+N+LH M PPLL
Sbjct: 84 ICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLL 143
Query: 141 HLDLKPANILLDAHYHVKISDFGLAKCNGLSHSHDLSMDGL--FGTIAYLPPERIR--EK 196
H DLK NILLD +HVKI+DFGL+K +S S S GTI Y+PPE +K
Sbjct: 144 HHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQK 203
Query: 197 SRLFDTKHDVYSFAIVIWGVLTQKKPFADEKNILHIMVKVVKGHRP-----ELPPVCRAR 251
SR KHD+YS+A++ W VL++K+PF D N L IM V +GHRP LP R
Sbjct: 204 SRA-SIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHR 262
Query: 252 PRACSHLIRLMQRCWQGDPRVRPTFQEITSETE 284
R +I L++ W +P RP+F + E E
Sbjct: 263 AR----MISLIESGWAQNPDERPSFLKCLIELE 291
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 192 bits (488), Expect = 1e-48
Identities = 123/337 (36%), Positives = 174/337 (51%), Gaps = 4/337 (1%)
Query: 431 VDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELL 490
VD + + LH+A G + AK LL ANPN G TPLH+A ++ V+ELL
Sbjct: 360 VDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELL 419
Query: 491 LARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQE 550
L S+ A E T +H AA G + L+ AS N + G T +H+A + GQ
Sbjct: 420 LKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQA 479
Query: 551 NIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHL 610
+VR L++ G V + KD PLH +A G IV+ L +Q G S NA T G TPLHL
Sbjct: 480 EVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQ-GASPNAATTSGYTPLHL 538
Query: 611 AAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDG 670
+A+ GH VA L+D + +++ + TPLHVAA+ G A LLL + A +A G
Sbjct: 539 SAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSG 598
Query: 671 YTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELV--SADVI 728
T LH+AA + LL+++ A A T LH+AA ++ L+ AD
Sbjct: 599 LTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADA- 657
Query: 729 DLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQS 765
+ QG++++HLAAQ H V LL A++NL +
Sbjct: 658 NAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSN 694
Score = 186 bits (472), Expect = 7e-47
Identities = 122/382 (31%), Positives = 191/382 (50%), Gaps = 32/382 (8%)
Query: 417 GDTSKLMKILQPQ-DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPL 475
G + ++LQ + +VD A G + LH+A AGQ E K L+ N AN N ++ G TPL
Sbjct: 85 GHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPL 144
Query: 476 HMAVERRVRGVVELLLARKISVNAKDEDQWT----------------------------- 506
+MA + VV+ LL S + ED +T
Sbjct: 145 YMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLP 204
Query: 507 ALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQ 566
ALH AA+ D + LLL+ + + + G TP+H+A +G N+ +LL R V
Sbjct: 205 ALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFT 264
Query: 567 GKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDL 626
++ PLH A+ +G+ +VKLL + G ++A+T DG TPLH A+ GH +V +L+D
Sbjct: 265 ARNDITPLHVASKRGNANMVKLLLDR-GAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDR 323
Query: 627 CSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATV 686
+ + + +PLH+A + H + +LLL + +T+D TALH+AA GH
Sbjct: 324 AAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVA 383
Query: 687 KLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQG 745
K+L+++KA+ A+ T LH+A +V+E L+ I E GL+ +H+AA
Sbjct: 384 KVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFM 443
Query: 746 RHAQTVETLLRHGAHINLQSLK 767
H V L+ HGA N +++
Sbjct: 444 GHVNIVSQLMHHGASPNTTNVR 465
Score = 184 bits (466), Expect = 4e-46
Identities = 119/357 (33%), Positives = 177/357 (49%), Gaps = 7/357 (1%)
Query: 421 KLMKILQPQ--DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMA 478
K+M++L + +SG + +H+A G L+ + A+PN +N RG T LHMA
Sbjct: 414 KVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMA 473
Query: 479 VERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGR 538
VV L+ V AK +D T LH +A+ G + LL++ AS N G
Sbjct: 474 ARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGY 533
Query: 539 TPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVN 598
TP+H++ + G E++ LL G +S+ K + PLH AA G L + LL Q S +
Sbjct: 534 TPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLL-QKSASPD 592
Query: 599 AQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLH 658
A G TPLH+AA + +VA +L+D + + + TPLH+AA+ A LL
Sbjct: 593 AAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLE 652
Query: 659 RGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEV 718
GA A+T G ++HLAA+ GH+ V LL+ A+V T LHLAA V
Sbjct: 653 YGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNV 712
Query: 719 VEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSLKFQGGHGP 774
E LV+ +D + G + LH+ + + V LL+H A +N K + G+ P
Sbjct: 713 AEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVN---AKTKNGYTP 766
Score = 179 bits (454), Expect = 9e-45
Identities = 113/331 (34%), Positives = 166/331 (50%), Gaps = 4/331 (1%)
Query: 431 VDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSN-RRGSTPLHMAVERRVRGVVEL 489
+D G + LH +G E+ + +LL+ A P LS + G +PLHMA + V+L
Sbjct: 294 IDAKTRDGLTPLHCGARSGHEQVVE-MLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQL 352
Query: 490 LLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQ 549
LL + V+ D TALH AA G ++LL+K A+ N G TP+H+AC+ +
Sbjct: 353 LLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNR 412
Query: 550 ENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLH 609
++ +LL+ G + + P+H AA+ GH+ IV L G S N + G T LH
Sbjct: 413 IKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHH-GASPNTTNVRGETALH 471
Query: 610 LAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSD 669
+AA+ G V R L+ + V + QTPLH++A G + LL +GA A T+
Sbjct: 472 MAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTS 531
Query: 670 GYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADVI- 728
GYT LHL+AR GH L++ A + T LH+AA +G EV L+
Sbjct: 532 GYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASP 591
Query: 729 DLFDEQGLSALHLAAQGRHAQTVETLLRHGA 759
D + GL+ LH+AA + + LL GA
Sbjct: 592 DAAGKSGLTPLHVAAHYDNQKVALLLLDQGA 622
Score = 170 bits (430), Expect = 5e-42
Identities = 110/338 (32%), Positives = 181/338 (53%), Gaps = 6/338 (1%)
Query: 430 DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVEL 489
D+++ +G + LHLA + G E LL AN + + ++G+T LH+A VV++
Sbjct: 66 DINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKV 125
Query: 490 LLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQ 549
L+ +VNA+ ++ +T L+ AAQ + LL+ AS + +G TP+ VA Q G
Sbjct: 126 LVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGH 185
Query: 550 ENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLH 609
+ +V +LL +GK LH AA + LL + + + ++ G TPLH
Sbjct: 186 DQVVSLLLENDT----KGKVRLPALHIAARKDDTKAAALLLQNDN-NADVESKSGFTPLH 240
Query: 610 LAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSD 669
+AA G+ VA +L++ + V+ + TPLHVA++ G+ + +LLL RGA +A T D
Sbjct: 241 IAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRD 300
Query: 670 GYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-I 728
G T LH AR+GH V++L++ A +L++ + LH+A H V+ L+ +V +
Sbjct: 301 GLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPV 360
Query: 729 DLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSL 766
D L+ALH+AA H + + LL A+ N ++L
Sbjct: 361 DDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKAL 398
Score = 165 bits (417), Expect = 2e-40
Identities = 99/314 (31%), Positives = 160/314 (50%), Gaps = 2/314 (0%)
Query: 442 LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKD 501
LH++ G+ + + LL A+PN + G TPLH++ V LL S++
Sbjct: 503 LHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITT 562
Query: 502 EDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGV 561
+ +T LH AA+ G LLL+K+AS + G TP+HVA + + + +LL +G
Sbjct: 563 KKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGA 622
Query: 562 DVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVAR 621
K+ + PLH AA + + I L + G NA T G +HLAAQ GH +
Sbjct: 623 SPHAAAKNGYTPLHIAAKKNQMDIATTLLEY-GADANAVTRQGIASVHLAAQEGHVDMVS 681
Query: 622 ILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNG 681
+L+ ++VN+ + TPLH+AA+ + A +L+++GA +A T GYT LH+ G
Sbjct: 682 LLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYG 741
Query: 682 HLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADVI-DLFDEQGLSALH 740
++ V L++ A V A+ T LH AA GH+ ++ L+ + + G +AL
Sbjct: 742 NIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALG 801
Query: 741 LAAQGRHAQTVETL 754
+A + + V+TL
Sbjct: 802 IARRLGYISVVDTL 815
Score = 107 bits (266), Expect = 6e-23
Identities = 69/208 (33%), Positives = 104/208 (50%), Gaps = 3/208 (1%)
Query: 418 DTSKLMKILQPQDVD--LALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPL 475
D K+ +L Q A +G + LH+A + Q + A LL A+ N R+G +
Sbjct: 609 DNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASV 668
Query: 476 HMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDF 535
H+A + +V LLL R +VN ++ T LH AAQ + +L+ + A V+
Sbjct: 669 HLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTK 728
Query: 536 EGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGV 595
G TP+HV C +G IV LL+ V+ + K+ + PLH AA QGH I+ +L Q
Sbjct: 729 MGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLL-QNNA 787
Query: 596 SVNAQTLDGRTPLHLAAQRGHYRVARIL 623
S N T++G T L +A + G+ V L
Sbjct: 788 SPNELTVNGNTALGIARRLGYISVVDTL 815
Score = 60.5 bits (145), Expect = 6e-09
Identities = 40/119 (33%), Positives = 61/119 (51%), Gaps = 5/119 (4%)
Query: 658 HRGAGKEAMTSDGYTALHL-AARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHS 716
HR ++ A +L AAR GHL ++ D+ ALHLA+ GH
Sbjct: 28 HRKRSRDRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHV 87
Query: 717 EVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSLKFQGGHGP 774
EVV EL+ + +D ++G +ALH+A+ A+ V+ L+ +GA++N QS Q G P
Sbjct: 88 EVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQS---QNGFTP 143
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 191 bits (486), Expect = 2e-48
Identities = 121/334 (36%), Positives = 177/334 (52%), Gaps = 5/334 (1%)
Query: 442 LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKD 501
LH+A A LL N+ NP++ ++ G TPLH+A V +LLL R SVN
Sbjct: 210 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 269
Query: 502 EDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGV 561
++ T LH A++ G+ RLLL++ A + + TP+H A ++G I ILL G
Sbjct: 270 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGA 329
Query: 562 DVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVAR 621
+ + K+ P+H AA HL V+LL Q ++ TLD TPLH+AA GH+RVA+
Sbjct: 330 PIQAKTKNGLSPIHMAAQGDHLDCVRLLL-QYDAEIDDITLDHLTPLHVAAHCGHHRVAK 388
Query: 622 ILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNG 681
+L+D + N +L TPLH+A + H LLL GA +A+T G T LH+A+ G
Sbjct: 389 VLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMG 448
Query: 682 HLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALH 740
HL VK L++ A +T LH+AA GH+EV + L+ ++ + + LH
Sbjct: 449 HLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLH 508
Query: 741 LAAQGRHAQTVETLLRHGAHINLQSLKFQGGHGP 774
AA+ H V+ LL + A+ NL + GH P
Sbjct: 509 CAARIGHTNMVKLLLENNANPNLAT---TAGHTP 539
Score = 186 bits (471), Expect = 9e-47
Identities = 122/361 (33%), Positives = 178/361 (49%), Gaps = 10/361 (2%)
Query: 431 VDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELL 490
+D +SG + LH+A G K LL A+PN+SN + TPLHMA V + L
Sbjct: 430 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 489
Query: 491 LARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQE 550
L K VNAK +D T LH AA+ G + +LLLE NA+ N G TP+H+A + G
Sbjct: 490 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 549
Query: 551 NIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHL 610
V LL + + K + PLH AA G + + +LL ++ NA +G TPLH+
Sbjct: 550 ETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLER-DAHPNAAGKNGLTPLHV 608
Query: 611 AAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDG 670
A + + ++L+ + + TPLH+AA+ AR LL G A + G
Sbjct: 609 AVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 668
Query: 671 YTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-ID 729
T LHLAA+ GH V LL+ ++A+ T LHL A GH V + L+ V +D
Sbjct: 669 VTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD 728
Query: 730 LFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQS--------LKFQGGHGPAATLLRR 781
G + LH+A+ + + V+ LL+H A +N ++ Q GH TLL +
Sbjct: 729 ATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLK 788
Query: 782 S 782
+
Sbjct: 789 N 789
Score = 182 bits (463), Expect = 8e-46
Identities = 122/380 (32%), Positives = 183/380 (48%), Gaps = 36/380 (9%)
Query: 418 DTSKLMKILQPQ-DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLH 476
DT +LQ + D+ +G + LH+A A+ LL A+ N + + G TPLH
Sbjct: 218 DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLH 277
Query: 477 MAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDE------------------- 517
+A R +V LLL R + K +D+ T LH AA+NG
Sbjct: 278 IASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 337
Query: 518 --------------SSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDV 563
RLLL+ +A ++++ + TP+HVA G + ++LL +G
Sbjct: 338 GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKP 397
Query: 564 SLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARIL 623
+ + + + PLH A + H+ +++LL K G S++A T G TPLH+A+ GH + + L
Sbjct: 398 NSRALNGFTPLHIACKKNHVRVMELLLKT-GASIDAVTESGLTPLHVASFMGHLPIVKNL 456
Query: 624 IDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHL 683
+ + NV ++ +TPLH+AA GHT A+ LL A A D T LH AAR GH
Sbjct: 457 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHT 516
Query: 684 ATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADVID-LFDEQGLSALHLA 742
VKLL+E A+ T LH+AA GH E V L+ + ++G + LH+A
Sbjct: 517 NMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVA 576
Query: 743 AQGRHAQTVETLLRHGAHIN 762
A+ + E LL AH N
Sbjct: 577 AKYGKVRVAELLLERDAHPN 596
Score = 167 bits (423), Expect = 3e-41
Identities = 97/263 (36%), Positives = 150/263 (57%), Gaps = 4/263 (1%)
Query: 438 GASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISV 497
G + LH+A + G+ A+ LL +A+PN + + G TPLH+AV +V+LLL R S
Sbjct: 569 GFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 628
Query: 498 NAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILL 557
++ + +T LH AA+ R LL+ S N +G TP+H+A Q G +V +LL
Sbjct: 629 HSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL 688
Query: 558 RRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHY 617
+ + +L K PLH A +GH+P+ +L K GV V+A T G TPLH+A+ G+
Sbjct: 689 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH-GVMVDATTRMGYTPLHVASHYGNI 747
Query: 618 RVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLA 677
++ + L+ +DVN + L +PLH AA+ GHT LLL GA ++SDG T L +A
Sbjct: 748 KLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 807
Query: 678 ARNGHLA---TVKLLVEEKADVL 697
R G+++ +K++ +E + VL
Sbjct: 808 KRLGYISVTDVLKVVTDETSFVL 830
Score = 158 bits (399), Expect = 2e-38
Identities = 121/409 (29%), Positives = 193/409 (47%), Gaps = 39/409 (9%)
Query: 392 EREPSTSDLGTTDVQKKKLVDAIVS-------GDTSKLMKILQPQ-DVDLALDSGASLLH 443
E+E S +KK DA S G+ K + L+ D++ +G + LH
Sbjct: 24 EKEESNRKRRNRSRDRKKKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLH 83
Query: 444 LAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDED 503
LA + G + LL + ++G+T LH+A VV L+ +VNA+ +
Sbjct: 84 LASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK 143
Query: 504 QWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIV---------- 553
+T L+ AAQ + LLE A+ N +G TP+ VA Q G EN+V
Sbjct: 144 GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKG 203
Query: 554 -------------------RILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPG 594
+LL+ + + K + PLH AA +L + +LL + G
Sbjct: 204 KVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR-G 262
Query: 595 VSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTAR 654
SVN +G TPLH+A++RG+ + R+L+D + + + TPLH AA GH +
Sbjct: 263 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 322
Query: 655 LLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHG 714
+LL GA +A T +G + +H+AA+ HL V+LL++ A++ + T LH+AA G
Sbjct: 323 ILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCG 382
Query: 715 HSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHIN 762
H V + L+ + G + LH+A + H + +E LL+ GA I+
Sbjct: 383 HHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 431
Score = 150 bits (378), Expect = 6e-36
Identities = 102/307 (33%), Positives = 149/307 (48%), Gaps = 2/307 (0%)
Query: 417 GDTSKLMKILQPQ-DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPL 475
G T+ + +L+ + +LA +G + LH+A G E LL A+ ++G TPL
Sbjct: 514 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL 573
Query: 476 HMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDF 535
H+A + V ELLL R NA ++ T LH A + + +LLL + S + +
Sbjct: 574 HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW 633
Query: 536 EGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGV 595
G TP+H+A + Q + R LL+ G + + PLH AA +GH +V LL +
Sbjct: 634 NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA- 692
Query: 596 SVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARL 655
+ N G TPLHL AQ GH VA +LI V+ + + TPLHVA+ G+ +
Sbjct: 693 NGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKF 752
Query: 656 LLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGH 715
LL A A T GY+ LH AA+ GH V LL++ A T L +A G+
Sbjct: 753 LLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGY 812
Query: 716 SEVVEEL 722
V + L
Sbjct: 813 ISVTDVL 819
Score = 52.0 bits (123), Expect = 2e-06
Identities = 32/101 (31%), Positives = 54/101 (53%), Gaps = 1/101 (0%)
Query: 668 SDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV 727
+D T+ AAR+G+L + D+ LHLA+ GH ++V EL+ ++
Sbjct: 43 ADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEI 102
Query: 728 I-DLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSLK 767
I + ++G +ALH+AA + V L+ +GA++N QS K
Sbjct: 103 ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK 143
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 191 bits (486), Expect = 2e-48
Identities = 121/334 (36%), Positives = 177/334 (52%), Gaps = 5/334 (1%)
Query: 442 LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKD 501
LH+A A LL N+ NP++ ++ G TPLH+A V +LLL R SVN
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 236
Query: 502 EDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGV 561
++ T LH A++ G+ RLLL++ A + + TP+H A ++G I ILL G
Sbjct: 237 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGA 296
Query: 562 DVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVAR 621
+ + K+ P+H AA HL V+LL Q ++ TLD TPLH+AA GH+RVA+
Sbjct: 297 PIQAKTKNGLSPIHMAAQGDHLDCVRLLL-QYDAEIDDITLDHLTPLHVAAHCGHHRVAK 355
Query: 622 ILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNG 681
+L+D + N +L TPLH+A + H LLL GA +A+T G T LH+A+ G
Sbjct: 356 VLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMG 415
Query: 682 HLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALH 740
HL VK L++ A +T LH+AA GH+EV + L+ ++ + + LH
Sbjct: 416 HLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLH 475
Query: 741 LAAQGRHAQTVETLLRHGAHINLQSLKFQGGHGP 774
AA+ H V+ LL + A+ NL + GH P
Sbjct: 476 CAARIGHTNMVKLLLENNANPNLAT---TAGHTP 506
Score = 186 bits (471), Expect = 9e-47
Identities = 122/361 (33%), Positives = 178/361 (49%), Gaps = 10/361 (2%)
Query: 431 VDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELL 490
+D +SG + LH+A G K LL A+PN+SN + TPLHMA V + L
Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Query: 491 LARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQE 550
L K VNAK +D T LH AA+ G + +LLLE NA+ N G TP+H+A + G
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 516
Query: 551 NIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHL 610
V LL + + K + PLH AA G + + +LL ++ NA +G TPLH+
Sbjct: 517 ETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLER-DAHPNAAGKNGLTPLHV 575
Query: 611 AAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDG 670
A + + ++L+ + + TPLH+AA+ AR LL G A + G
Sbjct: 576 AVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 635
Query: 671 YTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-ID 729
T LHLAA+ GH V LL+ ++A+ T LHL A GH V + L+ V +D
Sbjct: 636 VTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD 695
Query: 730 LFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQS--------LKFQGGHGPAATLLRR 781
G + LH+A+ + + V+ LL+H A +N ++ Q GH TLL +
Sbjct: 696 ATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLK 755
Query: 782 S 782
+
Sbjct: 756 N 756
Score = 182 bits (463), Expect = 8e-46
Identities = 122/380 (32%), Positives = 183/380 (48%), Gaps = 36/380 (9%)
Query: 418 DTSKLMKILQPQ-DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLH 476
DT +LQ + D+ +G + LH+A A+ LL A+ N + + G TPLH
Sbjct: 185 DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLH 244
Query: 477 MAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDE------------------- 517
+A R +V LLL R + K +D+ T LH AA+NG
Sbjct: 245 IASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 304
Query: 518 --------------SSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDV 563
RLLL+ +A ++++ + TP+HVA G + ++LL +G
Sbjct: 305 GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKP 364
Query: 564 SLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARIL 623
+ + + + PLH A + H+ +++LL K G S++A T G TPLH+A+ GH + + L
Sbjct: 365 NSRALNGFTPLHIACKKNHVRVMELLLKT-GASIDAVTESGLTPLHVASFMGHLPIVKNL 423
Query: 624 IDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHL 683
+ + NV ++ +TPLH+AA GHT A+ LL A A D T LH AAR GH
Sbjct: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHT 483
Query: 684 ATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADVID-LFDEQGLSALHLA 742
VKLL+E A+ T LH+AA GH E V L+ + ++G + LH+A
Sbjct: 484 NMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVA 543
Query: 743 AQGRHAQTVETLLRHGAHIN 762
A+ + E LL AH N
Sbjct: 544 AKYGKVRVAELLLERDAHPN 563
Score = 169 bits (429), Expect = 7e-42
Identities = 105/318 (33%), Positives = 171/318 (53%), Gaps = 18/318 (5%)
Query: 438 GASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISV 497
G + LH+A + G+ A+ LL +A+PN + + G TPLH+AV +V+LLL R S
Sbjct: 536 GFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 595
Query: 498 NAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILL 557
++ + +T LH AA+ R LL+ S N +G TP+H+A Q G +V +LL
Sbjct: 596 HSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL 655
Query: 558 RRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHY 617
+ + +L K PLH A +GH+P+ +L K GV V+A T G TPLH+A+ G+
Sbjct: 656 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH-GVMVDATTRMGYTPLHVASHYGNI 714
Query: 618 RVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLA 677
++ + L+ +DVN + L +PLH AA+ GHT LLL GA ++SDG T L +A
Sbjct: 715 KLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
Query: 678 ARNGHLA---TVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADVIDLFDEQ 734
R G+++ +K++ +E + VL + H E V +++D+ +++
Sbjct: 775 KRLGYISVTDVLKVVTDETSFVL-------------VSDKHRMSFPETVD-EILDVSEDE 820
Query: 735 GLSALHLAAQGRHAQTVE 752
G + A+ R ++ V+
Sbjct: 821 GEELISFKAERRDSRDVD 838
Score = 155 bits (393), Expect = 1e-37
Identities = 114/378 (30%), Positives = 184/378 (48%), Gaps = 32/378 (8%)
Query: 416 SGDTSKLMKILQPQ-DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTP 474
SG+ K + L+ D++ +G + LHLA + G + LL + ++G+T
Sbjct: 22 SGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTA 81
Query: 475 LHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVD 534
LH+A VV L+ +VNA+ + +T L+ AAQ + LLE A+ N
Sbjct: 82 LHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT 141
Query: 535 FEGRTPMHVACQHGQENIV-----------------------------RILLRRGVDVSL 565
+G TP+ VA Q G EN+V +LL+ + +
Sbjct: 142 EDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV 201
Query: 566 QGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILID 625
K + PLH AA +L + +LL + G SVN +G TPLH+A++RG+ + R+L+D
Sbjct: 202 LSKTGFTPLHIAAHYENLNVAQLLLNR-GASVNFTPQNGITPLHIASRRGNVIMVRLLLD 260
Query: 626 LCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLAT 685
+ + + TPLH AA GH + +LL GA +A T +G + +H+AA+ HL
Sbjct: 261 RGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320
Query: 686 VKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQ 744
V+LL++ A++ + T LH+AA GH V + L+ + G + LH+A +
Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACK 380
Query: 745 GRHAQTVETLLRHGAHIN 762
H + +E LL+ GA I+
Sbjct: 381 KNHVRVMELLLKTGASID 398
Score = 152 bits (383), Expect = 2e-36
Identities = 109/329 (33%), Positives = 168/329 (51%), Gaps = 9/329 (2%)
Query: 436 DSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAV-ERRVRGVVELLLARK 494
D+ S L A +G + A L N + N N+ G LH+A E V+ VVELL ++
Sbjct: 11 DAATSFLR-AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELL-HKE 68
Query: 495 ISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVR 554
I + + TALH AA G + R L+ A+VN +G TP+++A Q +V+
Sbjct: 69 IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVK 128
Query: 555 ILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQR 614
LL G + ++ +D + PL A QGH +V L ++ + LH+AA+
Sbjct: 129 FLLENGANQNVATEDGFTPLAVALQQGHENVVAHL-----INYGTKGKVRLPALHIAARN 183
Query: 615 GHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTAL 674
R A +L+ + +V S TPLH+AA + + A+LLL+RGA +G T L
Sbjct: 184 DDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPL 243
Query: 675 HLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDE 733
H+A+R G++ V+LL++ A + + T LH AA +GH + E L+ I +
Sbjct: 244 HIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTK 303
Query: 734 QGLSALHLAAQGRHAQTVETLLRHGAHIN 762
GLS +H+AAQG H V LL++ A I+
Sbjct: 304 NGLSPIHMAAQGDHLDCVRLLLQYDAEID 332
Score = 68.9 bits (167), Expect = 2e-11
Identities = 43/125 (34%), Positives = 65/125 (52%)
Query: 432 DLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLL 491
+L SG + LHL + G A L+ + + + R G TPLH+A +V+ LL
Sbjct: 662 NLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLL 721
Query: 492 ARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQEN 551
+ VNAK + ++ LH AAQ G LLL+ AS NEV +G TP+ +A + G +
Sbjct: 722 QHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYIS 781
Query: 552 IVRIL 556
+ +L
Sbjct: 782 VTDVL 786
Score = 52.0 bits (123), Expect = 2e-06
Identities = 32/101 (31%), Positives = 54/101 (53%), Gaps = 1/101 (0%)
Query: 668 SDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV 727
+D T+ AAR+G+L + D+ LHLA+ GH ++V EL+ ++
Sbjct: 10 ADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEI 69
Query: 728 I-DLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSLK 767
I + ++G +ALH+AA + V L+ +GA++N QS K
Sbjct: 70 ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK 110
Score = 45.4 bits (106), Expect = 2e-04
Identities = 31/93 (33%), Positives = 44/93 (47%)
Query: 431 VDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELL 490
VD G + LH+A G + K+LL + A+ N + G +PLH A ++ +V LL
Sbjct: 694 VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLL 753
Query: 491 LARKISVNAKDEDQWTALHFAAQNGDESSTRLL 523
L S N D T L A + G S T +L
Sbjct: 754 LKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 36.6 bits (83), Expect = 0.092
Identities = 27/72 (37%), Positives = 38/72 (52%), Gaps = 2/72 (2%)
Query: 421 KLMK-ILQPQ-DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMA 478
KL+K +LQ Q DV+ G S LH A + G + LL N A+PN + G+TPL +A
Sbjct: 715 KLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
Query: 479 VERRVRGVVELL 490
V ++L
Sbjct: 775 KRLGYISVTDVL 786
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 191 bits (486), Expect = 2e-48
Identities = 121/334 (36%), Positives = 177/334 (52%), Gaps = 5/334 (1%)
Query: 442 LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKD 501
LH+A A LL N+ NP++ ++ G TPLH+A V +LLL R SVN
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 236
Query: 502 EDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGV 561
++ T LH A++ G+ RLLL++ A + + TP+H A ++G I ILL G
Sbjct: 237 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGA 296
Query: 562 DVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVAR 621
+ + K+ P+H AA HL V+LL Q ++ TLD TPLH+AA GH+RVA+
Sbjct: 297 PIQAKTKNGLSPIHMAAQGDHLDCVRLLL-QYDAEIDDITLDHLTPLHVAAHCGHHRVAK 355
Query: 622 ILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNG 681
+L+D + N +L TPLH+A + H LLL GA +A+T G T LH+A+ G
Sbjct: 356 VLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMG 415
Query: 682 HLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALH 740
HL VK L++ A +T LH+AA GH+EV + L+ ++ + + LH
Sbjct: 416 HLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLH 475
Query: 741 LAAQGRHAQTVETLLRHGAHINLQSLKFQGGHGP 774
AA+ H V+ LL + A+ NL + GH P
Sbjct: 476 CAARIGHTNMVKLLLENNANPNLAT---TAGHTP 506
Score = 186 bits (471), Expect = 9e-47
Identities = 122/361 (33%), Positives = 178/361 (49%), Gaps = 10/361 (2%)
Query: 431 VDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELL 490
+D +SG + LH+A G K LL A+PN+SN + TPLHMA V + L
Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Query: 491 LARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQE 550
L K VNAK +D T LH AA+ G + +LLLE NA+ N G TP+H+A + G
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 516
Query: 551 NIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHL 610
V LL + + K + PLH AA G + + +LL ++ NA +G TPLH+
Sbjct: 517 ETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLER-DAHPNAAGKNGLTPLHV 575
Query: 611 AAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDG 670
A + + ++L+ + + TPLH+AA+ AR LL G A + G
Sbjct: 576 AVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 635
Query: 671 YTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-ID 729
T LHLAA+ GH V LL+ ++A+ T LHL A GH V + L+ V +D
Sbjct: 636 VTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD 695
Query: 730 LFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQS--------LKFQGGHGPAATLLRR 781
G + LH+A+ + + V+ LL+H A +N ++ Q GH TLL +
Sbjct: 696 ATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLK 755
Query: 782 S 782
+
Sbjct: 756 N 756
Score = 182 bits (463), Expect = 8e-46
Identities = 122/380 (32%), Positives = 183/380 (48%), Gaps = 36/380 (9%)
Query: 418 DTSKLMKILQPQ-DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLH 476
DT +LQ + D+ +G + LH+A A+ LL A+ N + + G TPLH
Sbjct: 185 DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLH 244
Query: 477 MAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDE------------------- 517
+A R +V LLL R + K +D+ T LH AA+NG
Sbjct: 245 IASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 304
Query: 518 --------------SSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDV 563
RLLL+ +A ++++ + TP+HVA G + ++LL +G
Sbjct: 305 GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKP 364
Query: 564 SLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARIL 623
+ + + + PLH A + H+ +++LL K G S++A T G TPLH+A+ GH + + L
Sbjct: 365 NSRALNGFTPLHIACKKNHVRVMELLLKT-GASIDAVTESGLTPLHVASFMGHLPIVKNL 423
Query: 624 IDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHL 683
+ + NV ++ +TPLH+AA GHT A+ LL A A D T LH AAR GH
Sbjct: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHT 483
Query: 684 ATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADVID-LFDEQGLSALHLA 742
VKLL+E A+ T LH+AA GH E V L+ + ++G + LH+A
Sbjct: 484 NMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVA 543
Query: 743 AQGRHAQTVETLLRHGAHIN 762
A+ + E LL AH N
Sbjct: 544 AKYGKVRVAELLLERDAHPN 563
Score = 169 bits (429), Expect = 7e-42
Identities = 105/318 (33%), Positives = 171/318 (53%), Gaps = 18/318 (5%)
Query: 438 GASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISV 497
G + LH+A + G+ A+ LL +A+PN + + G TPLH+AV +V+LLL R S
Sbjct: 536 GFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 595
Query: 498 NAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILL 557
++ + +T LH AA+ R LL+ S N +G TP+H+A Q G +V +LL
Sbjct: 596 HSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL 655
Query: 558 RRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHY 617
+ + +L K PLH A +GH+P+ +L K GV V+A T G TPLH+A+ G+
Sbjct: 656 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH-GVMVDATTRMGYTPLHVASHYGNI 714
Query: 618 RVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLA 677
++ + L+ +DVN + L +PLH AA+ GHT LLL GA ++SDG T L +A
Sbjct: 715 KLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
Query: 678 ARNGHLA---TVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADVIDLFDEQ 734
R G+++ +K++ +E + VL + H E V +++D+ +++
Sbjct: 775 KRLGYISVTDVLKVVTDETSFVL-------------VSDKHRMSFPETVD-EILDVSEDE 820
Query: 735 GLSALHLAAQGRHAQTVE 752
G + A+ R ++ V+
Sbjct: 821 GEELISFKAERRDSRDVD 838
Score = 155 bits (393), Expect = 1e-37
Identities = 114/378 (30%), Positives = 184/378 (48%), Gaps = 32/378 (8%)
Query: 416 SGDTSKLMKILQPQ-DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTP 474
SG+ K + L+ D++ +G + LHLA + G + LL + ++G+T
Sbjct: 22 SGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTA 81
Query: 475 LHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVD 534
LH+A VV L+ +VNA+ + +T L+ AAQ + LLE A+ N
Sbjct: 82 LHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT 141
Query: 535 FEGRTPMHVACQHGQENIV-----------------------------RILLRRGVDVSL 565
+G TP+ VA Q G EN+V +LL+ + +
Sbjct: 142 EDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV 201
Query: 566 QGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILID 625
K + PLH AA +L + +LL + G SVN +G TPLH+A++RG+ + R+L+D
Sbjct: 202 LSKTGFTPLHIAAHYENLNVAQLLLNR-GASVNFTPQNGITPLHIASRRGNVIMVRLLLD 260
Query: 626 LCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLAT 685
+ + + TPLH AA GH + +LL GA +A T +G + +H+AA+ HL
Sbjct: 261 RGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320
Query: 686 VKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQ 744
V+LL++ A++ + T LH+AA GH V + L+ + G + LH+A +
Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACK 380
Query: 745 GRHAQTVETLLRHGAHIN 762
H + +E LL+ GA I+
Sbjct: 381 KNHVRVMELLLKTGASID 398
Score = 152 bits (383), Expect = 2e-36
Identities = 109/329 (33%), Positives = 168/329 (51%), Gaps = 9/329 (2%)
Query: 436 DSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAV-ERRVRGVVELLLARK 494
D+ S L A +G + A L N + N N+ G LH+A E V+ VVELL ++
Sbjct: 11 DAATSFLR-AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELL-HKE 68
Query: 495 ISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVR 554
I + + TALH AA G + R L+ A+VN +G TP+++A Q +V+
Sbjct: 69 IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVK 128
Query: 555 ILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQR 614
LL G + ++ +D + PL A QGH +V L ++ + LH+AA+
Sbjct: 129 FLLENGANQNVATEDGFTPLAVALQQGHENVVAHL-----INYGTKGKVRLPALHIAARN 183
Query: 615 GHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTAL 674
R A +L+ + +V S TPLH+AA + + A+LLL+RGA +G T L
Sbjct: 184 DDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPL 243
Query: 675 HLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDE 733
H+A+R G++ V+LL++ A + + T LH AA +GH + E L+ I +
Sbjct: 244 HIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTK 303
Query: 734 QGLSALHLAAQGRHAQTVETLLRHGAHIN 762
GLS +H+AAQG H V LL++ A I+
Sbjct: 304 NGLSPIHMAAQGDHLDCVRLLLQYDAEID 332
Score = 68.9 bits (167), Expect = 2e-11
Identities = 43/125 (34%), Positives = 65/125 (52%)
Query: 432 DLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLL 491
+L SG + LHL + G A L+ + + + R G TPLH+A +V+ LL
Sbjct: 662 NLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLL 721
Query: 492 ARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQEN 551
+ VNAK + ++ LH AAQ G LLL+ AS NEV +G TP+ +A + G +
Sbjct: 722 QHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYIS 781
Query: 552 IVRIL 556
+ +L
Sbjct: 782 VTDVL 786
Score = 52.0 bits (123), Expect = 2e-06
Identities = 32/101 (31%), Positives = 54/101 (53%), Gaps = 1/101 (0%)
Query: 668 SDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV 727
+D T+ AAR+G+L + D+ LHLA+ GH ++V EL+ ++
Sbjct: 10 ADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEI 69
Query: 728 I-DLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSLK 767
I + ++G +ALH+AA + V L+ +GA++N QS K
Sbjct: 70 ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK 110
Score = 45.4 bits (106), Expect = 2e-04
Identities = 31/93 (33%), Positives = 44/93 (47%)
Query: 431 VDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELL 490
VD G + LH+A G + K+LL + A+ N + G +PLH A ++ +V LL
Sbjct: 694 VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLL 753
Query: 491 LARKISVNAKDEDQWTALHFAAQNGDESSTRLL 523
L S N D T L A + G S T +L
Sbjct: 754 LKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 36.6 bits (83), Expect = 0.092
Identities = 27/72 (37%), Positives = 38/72 (52%), Gaps = 2/72 (2%)
Query: 421 KLMK-ILQPQ-DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMA 478
KL+K +LQ Q DV+ G S LH A + G + LL N A+PN + G+TPL +A
Sbjct: 715 KLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
Query: 479 VERRVRGVVELL 490
V ++L
Sbjct: 775 KRLGYISVTDVL 786
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 191 bits (486), Expect = 2e-48
Identities = 121/334 (36%), Positives = 177/334 (52%), Gaps = 5/334 (1%)
Query: 442 LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKD 501
LH+A A LL N+ NP++ ++ G TPLH+A V +LLL R SVN
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 236
Query: 502 EDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGV 561
++ T LH A++ G+ RLLL++ A + + TP+H A ++G I ILL G
Sbjct: 237 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGA 296
Query: 562 DVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVAR 621
+ + K+ P+H AA HL V+LL Q ++ TLD TPLH+AA GH+RVA+
Sbjct: 297 PIQAKTKNGLSPIHMAAQGDHLDCVRLLL-QYDAEIDDITLDHLTPLHVAAHCGHHRVAK 355
Query: 622 ILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNG 681
+L+D + N +L TPLH+A + H LLL GA +A+T G T LH+A+ G
Sbjct: 356 VLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMG 415
Query: 682 HLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALH 740
HL VK L++ A +T LH+AA GH+EV + L+ ++ + + LH
Sbjct: 416 HLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLH 475
Query: 741 LAAQGRHAQTVETLLRHGAHINLQSLKFQGGHGP 774
AA+ H V+ LL + A+ NL + GH P
Sbjct: 476 CAARIGHTNMVKLLLENNANPNLAT---TAGHTP 506
Score = 186 bits (471), Expect = 9e-47
Identities = 122/361 (33%), Positives = 178/361 (49%), Gaps = 10/361 (2%)
Query: 431 VDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELL 490
+D +SG + LH+A G K LL A+PN+SN + TPLHMA V + L
Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Query: 491 LARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQE 550
L K VNAK +D T LH AA+ G + +LLLE NA+ N G TP+H+A + G
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 516
Query: 551 NIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHL 610
V LL + + K + PLH AA G + + +LL ++ NA +G TPLH+
Sbjct: 517 ETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLER-DAHPNAAGKNGLTPLHV 575
Query: 611 AAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDG 670
A + + ++L+ + + TPLH+AA+ AR LL G A + G
Sbjct: 576 AVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 635
Query: 671 YTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-ID 729
T LHLAA+ GH V LL+ ++A+ T LHL A GH V + L+ V +D
Sbjct: 636 VTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD 695
Query: 730 LFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQS--------LKFQGGHGPAATLLRR 781
G + LH+A+ + + V+ LL+H A +N ++ Q GH TLL +
Sbjct: 696 ATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLK 755
Query: 782 S 782
+
Sbjct: 756 N 756
Score = 182 bits (463), Expect = 8e-46
Identities = 122/380 (32%), Positives = 183/380 (48%), Gaps = 36/380 (9%)
Query: 418 DTSKLMKILQPQ-DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLH 476
DT +LQ + D+ +G + LH+A A+ LL A+ N + + G TPLH
Sbjct: 185 DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLH 244
Query: 477 MAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDE------------------- 517
+A R +V LLL R + K +D+ T LH AA+NG
Sbjct: 245 IASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 304
Query: 518 --------------SSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDV 563
RLLL+ +A ++++ + TP+HVA G + ++LL +G
Sbjct: 305 GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKP 364
Query: 564 SLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARIL 623
+ + + + PLH A + H+ +++LL K G S++A T G TPLH+A+ GH + + L
Sbjct: 365 NSRALNGFTPLHIACKKNHVRVMELLLKT-GASIDAVTESGLTPLHVASFMGHLPIVKNL 423
Query: 624 IDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHL 683
+ + NV ++ +TPLH+AA GHT A+ LL A A D T LH AAR GH
Sbjct: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHT 483
Query: 684 ATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADVID-LFDEQGLSALHLA 742
VKLL+E A+ T LH+AA GH E V L+ + ++G + LH+A
Sbjct: 484 NMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVA 543
Query: 743 AQGRHAQTVETLLRHGAHIN 762
A+ + E LL AH N
Sbjct: 544 AKYGKVRVAELLLERDAHPN 563
Score = 169 bits (429), Expect = 7e-42
Identities = 105/318 (33%), Positives = 171/318 (53%), Gaps = 18/318 (5%)
Query: 438 GASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISV 497
G + LH+A + G+ A+ LL +A+PN + + G TPLH+AV +V+LLL R S
Sbjct: 536 GFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 595
Query: 498 NAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILL 557
++ + +T LH AA+ R LL+ S N +G TP+H+A Q G +V +LL
Sbjct: 596 HSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL 655
Query: 558 RRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHY 617
+ + +L K PLH A +GH+P+ +L K GV V+A T G TPLH+A+ G+
Sbjct: 656 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH-GVMVDATTRMGYTPLHVASHYGNI 714
Query: 618 RVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLA 677
++ + L+ +DVN + L +PLH AA+ GHT LLL GA ++SDG T L +A
Sbjct: 715 KLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
Query: 678 ARNGHLA---TVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADVIDLFDEQ 734
R G+++ +K++ +E + VL + H E V +++D+ +++
Sbjct: 775 KRLGYISVTDVLKVVTDETSFVL-------------VSDKHRMSFPETVD-EILDVSEDE 820
Query: 735 GLSALHLAAQGRHAQTVE 752
G + A+ R ++ V+
Sbjct: 821 GEELISFKAERRDSRDVD 838
Score = 155 bits (393), Expect = 1e-37
Identities = 114/378 (30%), Positives = 184/378 (48%), Gaps = 32/378 (8%)
Query: 416 SGDTSKLMKILQPQ-DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTP 474
SG+ K + L+ D++ +G + LHLA + G + LL + ++G+T
Sbjct: 22 SGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTA 81
Query: 475 LHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVD 534
LH+A VV L+ +VNA+ + +T L+ AAQ + LLE A+ N
Sbjct: 82 LHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT 141
Query: 535 FEGRTPMHVACQHGQENIV-----------------------------RILLRRGVDVSL 565
+G TP+ VA Q G EN+V +LL+ + +
Sbjct: 142 EDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV 201
Query: 566 QGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILID 625
K + PLH AA +L + +LL + G SVN +G TPLH+A++RG+ + R+L+D
Sbjct: 202 LSKTGFTPLHIAAHYENLNVAQLLLNR-GASVNFTPQNGITPLHIASRRGNVIMVRLLLD 260
Query: 626 LCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLAT 685
+ + + TPLH AA GH + +LL GA +A T +G + +H+AA+ HL
Sbjct: 261 RGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320
Query: 686 VKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQ 744
V+LL++ A++ + T LH+AA GH V + L+ + G + LH+A +
Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACK 380
Query: 745 GRHAQTVETLLRHGAHIN 762
H + +E LL+ GA I+
Sbjct: 381 KNHVRVMELLLKTGASID 398
Score = 152 bits (383), Expect = 2e-36
Identities = 109/329 (33%), Positives = 168/329 (51%), Gaps = 9/329 (2%)
Query: 436 DSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAV-ERRVRGVVELLLARK 494
D+ S L A +G + A L N + N N+ G LH+A E V+ VVELL ++
Sbjct: 11 DAATSFLR-AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELL-HKE 68
Query: 495 ISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVR 554
I + + TALH AA G + R L+ A+VN +G TP+++A Q +V+
Sbjct: 69 IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVK 128
Query: 555 ILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQR 614
LL G + ++ +D + PL A QGH +V L ++ + LH+AA+
Sbjct: 129 FLLENGANQNVATEDGFTPLAVALQQGHENVVAHL-----INYGTKGKVRLPALHIAARN 183
Query: 615 GHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTAL 674
R A +L+ + +V S TPLH+AA + + A+LLL+RGA +G T L
Sbjct: 184 DDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPL 243
Query: 675 HLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDE 733
H+A+R G++ V+LL++ A + + T LH AA +GH + E L+ I +
Sbjct: 244 HIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTK 303
Query: 734 QGLSALHLAAQGRHAQTVETLLRHGAHIN 762
GLS +H+AAQG H V LL++ A I+
Sbjct: 304 NGLSPIHMAAQGDHLDCVRLLLQYDAEID 332
Score = 68.9 bits (167), Expect = 2e-11
Identities = 43/125 (34%), Positives = 65/125 (52%)
Query: 432 DLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLL 491
+L SG + LHL + G A L+ + + + R G TPLH+A +V+ LL
Sbjct: 662 NLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLL 721
Query: 492 ARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQEN 551
+ VNAK + ++ LH AAQ G LLL+ AS NEV +G TP+ +A + G +
Sbjct: 722 QHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYIS 781
Query: 552 IVRIL 556
+ +L
Sbjct: 782 VTDVL 786
Score = 52.0 bits (123), Expect = 2e-06
Identities = 32/101 (31%), Positives = 54/101 (53%), Gaps = 1/101 (0%)
Query: 668 SDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV 727
+D T+ AAR+G+L + D+ LHLA+ GH ++V EL+ ++
Sbjct: 10 ADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEI 69
Query: 728 I-DLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSLK 767
I + ++G +ALH+AA + V L+ +GA++N QS K
Sbjct: 70 ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK 110
Score = 45.4 bits (106), Expect = 2e-04
Identities = 31/93 (33%), Positives = 44/93 (47%)
Query: 431 VDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELL 490
VD G + LH+A G + K+LL + A+ N + G +PLH A ++ +V LL
Sbjct: 694 VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLL 753
Query: 491 LARKISVNAKDEDQWTALHFAAQNGDESSTRLL 523
L S N D T L A + G S T +L
Sbjct: 754 LKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 36.6 bits (83), Expect = 0.092
Identities = 27/72 (37%), Positives = 38/72 (52%), Gaps = 2/72 (2%)
Query: 421 KLMK-ILQPQ-DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMA 478
KL+K +LQ Q DV+ G S LH A + G + LL N A+PN + G+TPL +A
Sbjct: 715 KLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
Query: 479 VERRVRGVVELL 490
V ++L
Sbjct: 775 KRLGYISVTDVL 786
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 191 bits (486), Expect = 2e-48
Identities = 121/334 (36%), Positives = 177/334 (52%), Gaps = 5/334 (1%)
Query: 442 LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKD 501
LH+A A LL N+ NP++ ++ G TPLH+A V +LLL R SVN
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 236
Query: 502 EDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGV 561
++ T LH A++ G+ RLLL++ A + + TP+H A ++G I ILL G
Sbjct: 237 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGA 296
Query: 562 DVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVAR 621
+ + K+ P+H AA HL V+LL Q ++ TLD TPLH+AA GH+RVA+
Sbjct: 297 PIQAKTKNGLSPIHMAAQGDHLDCVRLLL-QYDAEIDDITLDHLTPLHVAAHCGHHRVAK 355
Query: 622 ILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNG 681
+L+D + N +L TPLH+A + H LLL GA +A+T G T LH+A+ G
Sbjct: 356 VLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMG 415
Query: 682 HLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALH 740
HL VK L++ A +T LH+AA GH+EV + L+ ++ + + LH
Sbjct: 416 HLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLH 475
Query: 741 LAAQGRHAQTVETLLRHGAHINLQSLKFQGGHGP 774
AA+ H V+ LL + A+ NL + GH P
Sbjct: 476 CAARIGHTNMVKLLLENNANPNLAT---TAGHTP 506
Score = 186 bits (471), Expect = 9e-47
Identities = 122/361 (33%), Positives = 178/361 (49%), Gaps = 10/361 (2%)
Query: 431 VDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELL 490
+D +SG + LH+A G K LL A+PN+SN + TPLHMA V + L
Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Query: 491 LARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQE 550
L K VNAK +D T LH AA+ G + +LLLE NA+ N G TP+H+A + G
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 516
Query: 551 NIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHL 610
V LL + + K + PLH AA G + + +LL ++ NA +G TPLH+
Sbjct: 517 ETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLER-DAHPNAAGKNGLTPLHV 575
Query: 611 AAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDG 670
A + + ++L+ + + TPLH+AA+ AR LL G A + G
Sbjct: 576 AVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 635
Query: 671 YTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-ID 729
T LHLAA+ GH V LL+ ++A+ T LHL A GH V + L+ V +D
Sbjct: 636 VTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD 695
Query: 730 LFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQS--------LKFQGGHGPAATLLRR 781
G + LH+A+ + + V+ LL+H A +N ++ Q GH TLL +
Sbjct: 696 ATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLK 755
Query: 782 S 782
+
Sbjct: 756 N 756
Score = 182 bits (463), Expect = 8e-46
Identities = 122/380 (32%), Positives = 183/380 (48%), Gaps = 36/380 (9%)
Query: 418 DTSKLMKILQPQ-DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLH 476
DT +LQ + D+ +G + LH+A A+ LL A+ N + + G TPLH
Sbjct: 185 DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLH 244
Query: 477 MAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDE------------------- 517
+A R +V LLL R + K +D+ T LH AA+NG
Sbjct: 245 IASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 304
Query: 518 --------------SSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDV 563
RLLL+ +A ++++ + TP+HVA G + ++LL +G
Sbjct: 305 GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKP 364
Query: 564 SLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARIL 623
+ + + + PLH A + H+ +++LL K G S++A T G TPLH+A+ GH + + L
Sbjct: 365 NSRALNGFTPLHIACKKNHVRVMELLLKT-GASIDAVTESGLTPLHVASFMGHLPIVKNL 423
Query: 624 IDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHL 683
+ + NV ++ +TPLH+AA GHT A+ LL A A D T LH AAR GH
Sbjct: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHT 483
Query: 684 ATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADVID-LFDEQGLSALHLA 742
VKLL+E A+ T LH+AA GH E V L+ + ++G + LH+A
Sbjct: 484 NMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVA 543
Query: 743 AQGRHAQTVETLLRHGAHIN 762
A+ + E LL AH N
Sbjct: 544 AKYGKVRVAELLLERDAHPN 563
Score = 169 bits (429), Expect = 7e-42
Identities = 105/318 (33%), Positives = 171/318 (53%), Gaps = 18/318 (5%)
Query: 438 GASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISV 497
G + LH+A + G+ A+ LL +A+PN + + G TPLH+AV +V+LLL R S
Sbjct: 536 GFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 595
Query: 498 NAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILL 557
++ + +T LH AA+ R LL+ S N +G TP+H+A Q G +V +LL
Sbjct: 596 HSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL 655
Query: 558 RRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHY 617
+ + +L K PLH A +GH+P+ +L K GV V+A T G TPLH+A+ G+
Sbjct: 656 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH-GVMVDATTRMGYTPLHVASHYGNI 714
Query: 618 RVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLA 677
++ + L+ +DVN + L +PLH AA+ GHT LLL GA ++SDG T L +A
Sbjct: 715 KLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
Query: 678 ARNGHLA---TVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADVIDLFDEQ 734
R G+++ +K++ +E + VL + H E V +++D+ +++
Sbjct: 775 KRLGYISVTDVLKVVTDETSFVL-------------VSDKHRMSFPETVD-EILDVSEDE 820
Query: 735 GLSALHLAAQGRHAQTVE 752
G + A+ R ++ V+
Sbjct: 821 GEELISFKAERRDSRDVD 838
Score = 155 bits (393), Expect = 1e-37
Identities = 114/378 (30%), Positives = 184/378 (48%), Gaps = 32/378 (8%)
Query: 416 SGDTSKLMKILQPQ-DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTP 474
SG+ K + L+ D++ +G + LHLA + G + LL + ++G+T
Sbjct: 22 SGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTA 81
Query: 475 LHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVD 534
LH+A VV L+ +VNA+ + +T L+ AAQ + LLE A+ N
Sbjct: 82 LHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT 141
Query: 535 FEGRTPMHVACQHGQENIV-----------------------------RILLRRGVDVSL 565
+G TP+ VA Q G EN+V +LL+ + +
Sbjct: 142 EDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV 201
Query: 566 QGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILID 625
K + PLH AA +L + +LL + G SVN +G TPLH+A++RG+ + R+L+D
Sbjct: 202 LSKTGFTPLHIAAHYENLNVAQLLLNR-GASVNFTPQNGITPLHIASRRGNVIMVRLLLD 260
Query: 626 LCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLAT 685
+ + + TPLH AA GH + +LL GA +A T +G + +H+AA+ HL
Sbjct: 261 RGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320
Query: 686 VKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQ 744
V+LL++ A++ + T LH+AA GH V + L+ + G + LH+A +
Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACK 380
Query: 745 GRHAQTVETLLRHGAHIN 762
H + +E LL+ GA I+
Sbjct: 381 KNHVRVMELLLKTGASID 398
Score = 152 bits (383), Expect = 2e-36
Identities = 109/329 (33%), Positives = 168/329 (51%), Gaps = 9/329 (2%)
Query: 436 DSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAV-ERRVRGVVELLLARK 494
D+ S L A +G + A L N + N N+ G LH+A E V+ VVELL ++
Sbjct: 11 DAATSFLR-AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELL-HKE 68
Query: 495 ISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVR 554
I + + TALH AA G + R L+ A+VN +G TP+++A Q +V+
Sbjct: 69 IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVK 128
Query: 555 ILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQR 614
LL G + ++ +D + PL A QGH +V L ++ + LH+AA+
Sbjct: 129 FLLENGANQNVATEDGFTPLAVALQQGHENVVAHL-----INYGTKGKVRLPALHIAARN 183
Query: 615 GHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTAL 674
R A +L+ + +V S TPLH+AA + + A+LLL+RGA +G T L
Sbjct: 184 DDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPL 243
Query: 675 HLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDE 733
H+A+R G++ V+LL++ A + + T LH AA +GH + E L+ I +
Sbjct: 244 HIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTK 303
Query: 734 QGLSALHLAAQGRHAQTVETLLRHGAHIN 762
GLS +H+AAQG H V LL++ A I+
Sbjct: 304 NGLSPIHMAAQGDHLDCVRLLLQYDAEID 332
Score = 68.9 bits (167), Expect = 2e-11
Identities = 43/125 (34%), Positives = 65/125 (52%)
Query: 432 DLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLL 491
+L SG + LHL + G A L+ + + + R G TPLH+A +V+ LL
Sbjct: 662 NLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLL 721
Query: 492 ARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQEN 551
+ VNAK + ++ LH AAQ G LLL+ AS NEV +G TP+ +A + G +
Sbjct: 722 QHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYIS 781
Query: 552 IVRIL 556
+ +L
Sbjct: 782 VTDVL 786
Score = 52.0 bits (123), Expect = 2e-06
Identities = 32/101 (31%), Positives = 54/101 (53%), Gaps = 1/101 (0%)
Query: 668 SDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV 727
+D T+ AAR+G+L + D+ LHLA+ GH ++V EL+ ++
Sbjct: 10 ADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEI 69
Query: 728 I-DLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSLK 767
I + ++G +ALH+AA + V L+ +GA++N QS K
Sbjct: 70 ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK 110
Score = 45.4 bits (106), Expect = 2e-04
Identities = 31/93 (33%), Positives = 44/93 (47%)
Query: 431 VDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELL 490
VD G + LH+A G + K+LL + A+ N + G +PLH A ++ +V LL
Sbjct: 694 VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLL 753
Query: 491 LARKISVNAKDEDQWTALHFAAQNGDESSTRLL 523
L S N D T L A + G S T +L
Sbjct: 754 LKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 36.6 bits (83), Expect = 0.092
Identities = 27/72 (37%), Positives = 38/72 (52%), Gaps = 2/72 (2%)
Query: 421 KLMK-ILQPQ-DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMA 478
KL+K +LQ Q DV+ G S LH A + G + LL N A+PN + G+TPL +A
Sbjct: 715 KLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
Query: 479 VERRVRGVVELL 490
V ++L
Sbjct: 775 KRLGYISVTDVL 786
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 182 bits (462), Expect = 1e-45
Identities = 121/353 (34%), Positives = 178/353 (50%), Gaps = 4/353 (1%)
Query: 410 LVDAIVSGDTSKLMKIL-QPQDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSN 468
LV AI +GD ++ ++ + +DV+ + + LH A G E + L+L+ A N +
Sbjct: 12 LVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKD 71
Query: 469 RRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNA 528
+ TPLH AV V++LL VNA+D++ T LH AA N L+ +
Sbjct: 72 SKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLS 131
Query: 529 SVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKL 588
+VN D GRT +H A G +V++LL RG +++ K +H+AA+ GH+ +VKL
Sbjct: 132 NVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKL 191
Query: 589 LAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETG 648
L G V + TPLH AA G V + L+DL D+N + TPLHVA G
Sbjct: 192 LVSH-GAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNG 250
Query: 649 HTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLA-TVKLLVEEKADVLARGPLNQTAL 707
L+ GA G+T LH AA + H A ++LLV ADV + +T L
Sbjct: 251 QDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPL 310
Query: 708 HLAAAHGHSEVVEELV-SADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGA 759
H+ A HG + ++ S VID D+ G + LH+AA+ H + TL+ GA
Sbjct: 311 HMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGA 363
Score = 160 bits (406), Expect = 3e-39
Identities = 111/369 (30%), Positives = 178/369 (48%), Gaps = 3/369 (0%)
Query: 397 TSDLGTTDVQKKKLVDAIVSGDTSKLMKILQP--QDVDLALDSGASLLHLAVEAGQEECA 454
++D+ D + + + K + L P +V+++ +G + LH A +G E
Sbjct: 97 SADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMV 156
Query: 455 KWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQN 514
K LL AN N +++ +H A VV+LL++ V KD+ +T LH AA +
Sbjct: 157 KLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASS 216
Query: 515 GDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPL 574
G S + LL+ +NE + G TP+HVAC +GQ+ +V L+ G V+ + + + PL
Sbjct: 217 GMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPL 276
Query: 575 HYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCS 634
H+AA H + L G VN ++ DG+TPLH+ A G + ++ +I + ++
Sbjct: 277 HFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCED 336
Query: 635 LLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKA 694
TPLH+AA GH L+ GA G LHLAA +G + L+
Sbjct: 337 KNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGF 396
Query: 695 DVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVET 753
D+ +T LH AAA G+ E + L++ + D+ G S LH AA + Q +
Sbjct: 397 DIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFA 456
Query: 754 LLRHGAHIN 762
L+ GA +N
Sbjct: 457 LVGSGASVN 465
Score = 143 bits (361), Expect = 5e-34
Identities = 113/380 (29%), Positives = 173/380 (45%), Gaps = 23/380 (6%)
Query: 399 DLGTTDVQKKKLVDAIVSGDTSKLMKILQPQDVDLALDS--GASLLHLAVEAGQEECAKW 456
D+ T D + + A +G + + +L D G S LH A +C
Sbjct: 397 DIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFA 456
Query: 457 LLLNNANPNLSNRRGSTPLHMAVERRVRG-VVELLLARKISVNAKDEDQWTALHFAAQNG 515
L+ + A+ N + RG TPLH A G +E LL + +D+ + A+H++A G
Sbjct: 457 LVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYG 516
Query: 516 ---------DESSTRLLLEKNASVNEVDFEGR---TPMHVACQHGQENIVRILLRRGVDV 563
E+ +L+E + + D + R +P+H+A HG + +L++ +D+
Sbjct: 517 HRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDL 576
Query: 564 SLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARIL 623
++ PL AA++GH+ V +L Q + + RTP+H AA GH R+L
Sbjct: 577 DVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLL 636
Query: 624 IDLCSDVNVCSLL---AQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARN 680
I N + QTPL ++ GHT LL++GA +A G TALH A
Sbjct: 637 IGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVT 696
Query: 681 GHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELV-SADVID----LFDEQG 735
GH V L++ A L R +T +HL+AA GH V+ L+ SA +D D G
Sbjct: 697 GHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHG 756
Query: 736 LSALHLAAQGRHAQTVETLL 755
+ALH A H VE LL
Sbjct: 757 YTALHWACYNGHETCVELLL 776
Score = 130 bits (327), Expect = 5e-30
Identities = 113/363 (31%), Positives = 163/363 (44%), Gaps = 60/363 (16%)
Query: 431 VDLALDSGASLL-----------HLAVEAGQEECAKWLLLNNANP----NLSNRRGSTPL 475
VD+ ++ GAS+L H A G EC + LL+ NA P ++ + G TPL
Sbjct: 599 VDVLINQGASILVKDYILKRTPIHAAATNGHSECLR-LLIGNAEPQNAVDIQDGNGQTPL 657
Query: 476 HMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDF 535
++V V LL + +V+AKD+ TALH A G E LL+ A D
Sbjct: 658 MLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDS 717
Query: 536 EGRTPMHV-------------------------------------ACQHGQENIVRILLR 558
GRTP+H+ AC +G E V +LL
Sbjct: 718 RGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLE 777
Query: 559 RGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVS-VNAQTLDGRTPLHLAAQRGHY 617
+ V +G +A+ PLH A + ++L G S VNA GRTPLH AA H
Sbjct: 778 QEVFQKTEG-NAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHV 836
Query: 618 RVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGY-TALHL 676
++L+ + VN +TPL +AAE G T+T +L+ + + + + TALHL
Sbjct: 837 ECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHL 896
Query: 677 AARNGHLATVKLLVEEKAD---VLARGPLNQTALHLAAAHGHSEVVEELVSADVIDL-FD 732
A GH + L++E+ D + A QT LH+AA +G + VV+EL+ L D
Sbjct: 897 ACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVD 956
Query: 733 EQG 735
E G
Sbjct: 957 ENG 959
Score = 128 bits (322), Expect = 2e-29
Identities = 104/381 (27%), Positives = 167/381 (43%), Gaps = 54/381 (14%)
Query: 431 VDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELL 490
+D +G + LH+A G E L+ + A+ G PLH+A L
Sbjct: 332 IDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKL 391
Query: 491 LARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQH--- 547
L+ ++ D+ T LH AA G+ LLL A N+ D GR+P+H A +
Sbjct: 392 LSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNY 451
Query: 548 -------------------------------GQENIVRILLRRGVDVSLQGKDAWLPLHY 576
+ LLR + ++ K + +HY
Sbjct: 452 QCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHY 511
Query: 577 AAWQGHLPIVKLLAKQPGVSVNAQT--------LDGR---TPLHLAAQRGHYRVARILID 625
+A GH ++L+A + + V +T D R +PLHLAA GH++ +L+
Sbjct: 512 SAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQ 571
Query: 626 LCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSD---GYTALHLAARNGH 682
D++V + +TPL +AA GH +L+++GA + D T +H AA NGH
Sbjct: 572 SLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGA--SILVKDYILKRTPIHAAATNGH 629
Query: 683 LATVKLLV---EEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSA 738
++LL+ E + V + QT L L+ +GH++ V L++ +D D+ G +A
Sbjct: 630 SECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTA 689
Query: 739 LHLAAQGRHAQTVETLLRHGA 759
LH A H + V+ LL+HGA
Sbjct: 690 LHRGAVTGHEECVDALLQHGA 710
Score = 120 bits (301), Expect = 5e-27
Identities = 90/306 (29%), Positives = 146/306 (47%), Gaps = 13/306 (4%)
Query: 468 NRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKN 527
NR +PLH+A +E+L+ + ++ ++ T L AA G +L+ +
Sbjct: 547 NRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQG 606
Query: 528 ASVNEVDFE-GRTPMHVACQHGQENIVRILLRRGVD---VSLQGKDAWLPLHYAAWQGHL 583
AS+ D+ RTP+H A +G +R+L+ V +Q + PL + GH
Sbjct: 607 ASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHT 666
Query: 584 PIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHV 643
V L + G +V+A+ GRT LH A GH L+ + + +TP+H+
Sbjct: 667 DCVYSLLNK-GANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHL 725
Query: 644 AAETGHTSTARLLLHRGAGKEA--MTSD--GYTALHLAARNGHLATVKLLVEEKADVLAR 699
+A GH LL A +A T+D GYTALH A NGH V+LL+E++
Sbjct: 726 SAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTE 785
Query: 700 GPLNQTALHLAAAH---GHSEVVEELVSADVIDLFDEQGLSALHLAAQGRHAQTVETLLR 756
G + LH A + G +E++ + + A +++ D +G + LH AA H + ++ LL
Sbjct: 786 GNAF-SPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLS 844
Query: 757 HGAHIN 762
H A +N
Sbjct: 845 HNAQVN 850
Score = 119 bits (299), Expect = 8e-27
Identities = 96/337 (28%), Positives = 145/337 (43%), Gaps = 43/337 (12%)
Query: 410 LVDAIVSGDTSKLMKILQP-QDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSN 468
L+ ++++G T + +L +VD G + LH G EEC LL + A L +
Sbjct: 657 LMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRD 716
Query: 469 RRGSTPLHMAVERRVRGVVELLLARKISVNAK----DEDQWTALHFAAQNGDESSTRLLL 524
RG TP+H++ GV+ LL S++A D +TALH+A NG E+ LLL
Sbjct: 717 SRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLL 776
Query: 525 EKN----------------------------------ASVNEVDFEGRTPMHVACQHGQE 550
E+ + VN D +GRTP+H A
Sbjct: 777 EQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHV 836
Query: 551 NIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHL 610
+++LL V+ PL AA G V++L + Q T LHL
Sbjct: 837 ECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHL 896
Query: 611 AAQRGHYRVARILIDLCSD---VNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMT 667
A +GH A ++++ +D +N + QTPLHVAA G T + LL +GA A+
Sbjct: 897 ACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVD 956
Query: 668 SDGYTALHLAARNGHLA-TVKLLVEEKADVLARGPLN 703
+GYT A N +A + L++ V + PL+
Sbjct: 957 ENGYTPALACAPNKDVADCLALILATMMPVSSSSPLS 993
Score = 85.9 bits (211), Expect = 1e-16
Identities = 59/172 (34%), Positives = 85/172 (49%), Gaps = 1/172 (0%)
Query: 597 VNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLL 656
VN Q + RTPLH AA G + +LI + VN TPLH A + ++L
Sbjct: 34 VNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVL 93
Query: 657 LHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHS 716
L A A + T LH+AA N + + LV ++V +TALH AA GH
Sbjct: 94 LKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHG 153
Query: 717 EVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSLK 767
E+V+ L+S I+ FD++ A+H AA H + V+ L+ HGA + + K
Sbjct: 154 EMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKK 205
Score = 44.7 bits (104), Expect = 3e-04
Identities = 44/159 (27%), Positives = 62/159 (38%), Gaps = 34/159 (21%)
Query: 638 QTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLV------- 690
Q L A G R L+ + ++ T LH AA G ++LL+
Sbjct: 9 QPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVN 68
Query: 691 --------------------------EEKADVLARGPLNQTALHLAAAHGHSEVVEELVS 724
+ ADV AR QT LH+AAA+ + E LV
Sbjct: 69 AKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVP 128
Query: 725 -ADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHIN 762
+++ D G +ALH AA H + V+ LL GA+IN
Sbjct: 129 LLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANIN 167
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 179 bits (455), Expect = 7e-45
Identities = 109/326 (33%), Positives = 172/326 (52%), Gaps = 2/326 (0%)
Query: 438 GASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISV 497
G + LH+A AGQ E + LL N A + R TPLH+A +V+LLL
Sbjct: 443 GETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHP 502
Query: 498 NAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILL 557
+A + +T LH +A+ G +LLE A+ + +G TP+HVA ++G ++ ++LL
Sbjct: 503 DAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL 562
Query: 558 RRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHY 617
+R GK+ PLH AA + + LL ++ G S +A +G TPLH+AA++
Sbjct: 563 QRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEK-GASPHATAKNGYTPLHIAAKKNQM 621
Query: 618 RVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLA 677
++A L++ ++ N+ + TPLH+A++ GHT LLL +GA T G T+LHLA
Sbjct: 622 QIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLA 681
Query: 678 ARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGL 736
A+ + +L + AD A L T L +A +G+ ++V L+ ++ + G
Sbjct: 682 AQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGY 741
Query: 737 SALHLAAQGRHAQTVETLLRHGAHIN 762
+ LH AAQ H + LL+HGA N
Sbjct: 742 TPLHQAAQQGHTHIINVLLQHGAKPN 767
Score = 178 bits (451), Expect = 2e-44
Identities = 117/335 (34%), Positives = 176/335 (52%), Gaps = 3/335 (0%)
Query: 432 DLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLL 491
D+ LD + LH+A G K LL ANPN G TPLH+A ++ V+ELL+
Sbjct: 339 DVTLDY-LTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLV 397
Query: 492 ARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQEN 551
S+ A E T +H AA G + LLL+ AS + + G T +H+A + GQ
Sbjct: 398 KYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVE 457
Query: 552 IVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLA 611
+VR LLR G V + ++ PLH A+ G IV+LL Q +A T +G TPLH++
Sbjct: 458 VVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLL-QHMAHPDAATTNGYTPLHIS 516
Query: 612 AQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGY 671
A+ G VA +L++ + ++ + TPLHVAA+ G A+LLL R A ++ +G
Sbjct: 517 AREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGL 576
Query: 672 TALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDL 730
T LH+AA + LL+E+ A A T LH+AA ++ L++ ++
Sbjct: 577 TPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI 636
Query: 731 FDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQS 765
+QG++ LHLA+Q H V LL GA+I++ +
Sbjct: 637 VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMST 671
Score = 172 bits (435), Expect = 1e-42
Identities = 115/345 (33%), Positives = 176/345 (51%), Gaps = 3/345 (0%)
Query: 417 GDTSKLMKIL-QPQDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPL 475
G+T+ + +L + +D G + LH A +G ++ + LL A + G +PL
Sbjct: 256 GNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPL 315
Query: 476 HMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDF 535
HMA + V+ LL K V+ D TALH AA G T+LLL+K A+ N
Sbjct: 316 HMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARAL 375
Query: 536 EGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGV 595
G TP+H+AC+ + ++ +L++ G + + P+H AA+ GHL IV LL Q G
Sbjct: 376 NGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIV-LLLLQNGA 434
Query: 596 SVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARL 655
S + + G T LH+AA+ G V R L+ + V+ + QTPLH+A+ G T +L
Sbjct: 435 SPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQL 494
Query: 656 LLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGH 715
LL A +A T++GYT LH++AR G + +L+E A T LH+AA +G
Sbjct: 495 LLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGS 554
Query: 716 SEVVEELVS-ADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGA 759
+V + L+ D + GL+ LH+AA + + LL GA
Sbjct: 555 LDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGA 599
Score = 169 bits (427), Expect = 1e-41
Identities = 125/378 (33%), Positives = 196/378 (51%), Gaps = 17/378 (4%)
Query: 402 TTDVQKK----KLVDAIVSGDTSKLMKILQPQ-DVDLALDSGASLLHLAVEAGQEECAKW 456
TT +QK + A +G+ K+++ L+ D++ +G + LHLA + G +
Sbjct: 2 TTMLQKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQE 61
Query: 457 LLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGD 516
LL ++ + + ++G+T LH+A VV++L+ ++NA+ ++ +T L+ AAQ
Sbjct: 62 LLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENH 121
Query: 517 ESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHY 576
+ LLE A+ + +G TP+ VA Q G V ILL +GK LH
Sbjct: 122 IDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDT----KGKVRLPALHI 177
Query: 577 AAWQGHLPIVKLLAK-------QPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSD 629
AA + LL + Q + VN T G TPLH+AA G+ VA +L++ +
Sbjct: 178 AARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAA 237
Query: 630 VNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLL 689
V+ + TPLHVA++ G+T+ +LLL RG +A T DG T LH AAR+GH V+LL
Sbjct: 238 VDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELL 297
Query: 690 VEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHA 748
+E A +LAR + LH+AA H E V+ L+ +D L+ALH+AA H
Sbjct: 298 LERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHY 357
Query: 749 QTVETLLRHGAHINLQSL 766
+ + LL A+ N ++L
Sbjct: 358 RVTKLLLDKRANPNARAL 375
Score = 158 bits (400), Expect = 2e-38
Identities = 114/343 (33%), Positives = 177/343 (51%), Gaps = 17/343 (4%)
Query: 436 DSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKI 495
DS AS L A AG + L + N N+ G LH+A + G+V+ LL R
Sbjct: 9 DSNASFLR-AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGS 67
Query: 496 SVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRI 555
SV++ + TALH A+ G ++L+++ A++N G TP+++A Q ++V+
Sbjct: 68 SVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKY 127
Query: 556 LLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTP-LHLAAQR 614
LL G + S +D + PL A QGH V +L + N R P LH+AA++
Sbjct: 128 LLENGANQSTATEDGFTPLAVALQQGHNQAVAILLE------NDTKGKVRLPALHIAARK 181
Query: 615 GHYRVARILIDLCSDVNVCSLLAQ--------TPLHVAAETGHTSTARLLLHRGAGKEAM 666
+ A +L+ + +V S + TPLH+AA G+ + A LLL+RGA +
Sbjct: 182 DDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFT 241
Query: 667 TSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSAD 726
+G T LH+A++ G+ VKLL++ + A+ T LH AA GH +VVE L+
Sbjct: 242 ARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERG 301
Query: 727 VIDLF-DEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSLKF 768
L + GLS LH+AAQG H + V+ LL+H A ++ +L +
Sbjct: 302 APLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDY 344
Score = 156 bits (395), Expect = 6e-38
Identities = 96/314 (30%), Positives = 160/314 (50%), Gaps = 2/314 (0%)
Query: 442 LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKD 501
LH+A G+ E + LL + A+P+ + G TPLH++ V +LL + +
Sbjct: 480 LHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLAT 539
Query: 502 EDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGV 561
+ +T LH AA+ G +LLL++ A+ + G TP+HVA + + + +LL +G
Sbjct: 540 KKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGA 599
Query: 562 DVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVAR 621
K+ + PLH AA + + I L G N T G TPLHLA+Q GH +
Sbjct: 600 SPHATAKNGYTPLHIAAKKNQMQIASTLLNY-GAETNIVTKQGVTPLHLASQEGHTDMVT 658
Query: 622 ILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNG 681
+L+D +++++ + T LH+AA+ + A +L GA ++A T GYT L +A G
Sbjct: 659 LLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYG 718
Query: 682 HLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALH 740
++ V L+++ A+V A+ T LH AA GH+ ++ L+ + G +AL
Sbjct: 719 NVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALA 778
Query: 741 LAAQGRHAQTVETL 754
+A + + V+TL
Sbjct: 779 IAKRLGYISVVDTL 792
Score = 108 bits (269), Expect = 2e-23
Identities = 74/234 (31%), Positives = 116/234 (49%), Gaps = 3/234 (1%)
Query: 437 SGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKIS 496
+G + LH+A + Q + A LL A N+ ++G TPLH+A + +V LLL + +
Sbjct: 607 NGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGAN 666
Query: 497 VNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRIL 556
++ + T+LH AAQ + +L + A + G TP+ VAC +G +V L
Sbjct: 667 IHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFL 726
Query: 557 LRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGH 616
L++G +V+ + K+ + PLH AA QGH I+ +L Q G NA T +G T L +A + G+
Sbjct: 727 LKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLL-QHGAKPNATTANGNTALAIAKRLGY 785
Query: 617 YRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDG 670
V L + +V + T H T T L + G + MT DG
Sbjct: 786 ISVVDTLKVVTEEVTTTTTTI-TEKH-KLNVPETMTEVLDVSDEEGDDTMTGDG 837
Score = 70.5 bits (171), Expect = 6e-12
Identities = 44/160 (27%), Positives = 74/160 (46%)
Query: 430 DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVEL 489
+ ++ G + LHLA + G + LL AN ++S + G T LH+A + V ++
Sbjct: 633 ETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADI 692
Query: 490 LLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQ 549
L +A + +T L A G+ LL++ A+VN G TP+H A Q G
Sbjct: 693 LTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGH 752
Query: 550 ENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLL 589
+I+ +LL+ G + + L A G++ +V L
Sbjct: 753 THIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 792
Score = 38.5 bits (88), Expect = 0.024
Identities = 24/72 (33%), Positives = 38/72 (52%)
Query: 696 VLARGPLNQTALHLAAAHGHSEVVEELVSADVIDLFDEQGLSALHLAAQGRHAQTVETLL 755
+L + N + L A A +VVE L I+ ++ GL+ALHLAA+ H V+ LL
Sbjct: 4 MLQKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELL 63
Query: 756 RHGAHINLQSLK 767
G+ ++ + K
Sbjct: 64 GRGSSVDSATKK 75
Score = 30.0 bits (66), Expect = 8.6
Identities = 19/64 (29%), Positives = 29/64 (45%)
Query: 427 QPQDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGV 486
Q +V+ +G + LH A + G LL + A PN + G+T L +A V
Sbjct: 729 QGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISV 788
Query: 487 VELL 490
V+ L
Sbjct: 789 VDTL 792
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 179 bits (455), Expect = 7e-45
Identities = 109/326 (33%), Positives = 172/326 (52%), Gaps = 2/326 (0%)
Query: 438 GASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISV 497
G + LH+A AGQ E + LL N A + R TPLH+A +V+LLL
Sbjct: 464 GETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHP 523
Query: 498 NAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILL 557
+A + +T LH +A+ G +LLE A+ + +G TP+HVA ++G ++ ++LL
Sbjct: 524 DAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL 583
Query: 558 RRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHY 617
+R GK+ PLH AA + + LL ++ G S +A +G TPLH+AA++
Sbjct: 584 QRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEK-GASPHATAKNGYTPLHIAAKKNQM 642
Query: 618 RVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLA 677
++A L++ ++ N+ + TPLH+A++ GHT LLL +GA T G T+LHLA
Sbjct: 643 QIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLA 702
Query: 678 ARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGL 736
A+ + +L + AD A L T L +A +G+ ++V L+ ++ + G
Sbjct: 703 AQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGY 762
Query: 737 SALHLAAQGRHAQTVETLLRHGAHIN 762
+ LH AAQ H + LL+HGA N
Sbjct: 763 TPLHQAAQQGHTHIINVLLQHGAKPN 788
Score = 178 bits (451), Expect = 2e-44
Identities = 117/335 (34%), Positives = 176/335 (52%), Gaps = 3/335 (0%)
Query: 432 DLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLL 491
D+ LD + LH+A G K LL ANPN G TPLH+A ++ V+ELL+
Sbjct: 360 DVTLDY-LTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLV 418
Query: 492 ARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQEN 551
S+ A E T +H AA G + LLL+ AS + + G T +H+A + GQ
Sbjct: 419 KYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVE 478
Query: 552 IVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLA 611
+VR LLR G V + ++ PLH A+ G IV+LL Q +A T +G TPLH++
Sbjct: 479 VVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLL-QHMAHPDAATTNGYTPLHIS 537
Query: 612 AQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGY 671
A+ G VA +L++ + ++ + TPLHVAA+ G A+LLL R A ++ +G
Sbjct: 538 AREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGL 597
Query: 672 TALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDL 730
T LH+AA + LL+E+ A A T LH+AA ++ L++ ++
Sbjct: 598 TPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI 657
Query: 731 FDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQS 765
+QG++ LHLA+Q H V LL GA+I++ +
Sbjct: 658 VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMST 692
Score = 172 bits (435), Expect = 1e-42
Identities = 115/345 (33%), Positives = 176/345 (51%), Gaps = 3/345 (0%)
Query: 417 GDTSKLMKIL-QPQDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPL 475
G+T+ + +L + +D G + LH A +G ++ + LL A + G +PL
Sbjct: 277 GNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPL 336
Query: 476 HMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDF 535
HMA + V+ LL K V+ D TALH AA G T+LLL+K A+ N
Sbjct: 337 HMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARAL 396
Query: 536 EGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGV 595
G TP+H+AC+ + ++ +L++ G + + P+H AA+ GHL IV LL Q G
Sbjct: 397 NGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIV-LLLLQNGA 455
Query: 596 SVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARL 655
S + + G T LH+AA+ G V R L+ + V+ + QTPLH+A+ G T +L
Sbjct: 456 SPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQL 515
Query: 656 LLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGH 715
LL A +A T++GYT LH++AR G + +L+E A T LH+AA +G
Sbjct: 516 LLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGS 575
Query: 716 SEVVEELVS-ADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGA 759
+V + L+ D + GL+ LH+AA + + LL GA
Sbjct: 576 LDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGA 620
Score = 168 bits (425), Expect = 2e-41
Identities = 120/360 (33%), Positives = 189/360 (52%), Gaps = 13/360 (3%)
Query: 416 SGDTSKLMKILQPQ-DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTP 474
+G+ K+++ L+ D++ +G + LHLA + G + LL ++ + + ++G+T
Sbjct: 41 AGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTA 100
Query: 475 LHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVD 534
LH+A VV++L+ ++NA+ ++ +T L+ AAQ + LLE A+ +
Sbjct: 101 LHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTAT 160
Query: 535 FEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAK--- 591
+G TP+ VA Q G V ILL +GK LH AA + LL +
Sbjct: 161 EDGFTPLAVALQQGHNQAVAILLENDT----KGKVRLPALHIAARKDDTKSAALLLQNDH 216
Query: 592 ----QPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAET 647
Q + VN T G TPLH+AA G+ VA +L++ + V+ + TPLHVA++
Sbjct: 217 NADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKR 276
Query: 648 GHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTAL 707
G+T+ +LLL RG +A T DG T LH AAR+GH V+LL+E A +LAR + L
Sbjct: 277 GNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPL 336
Query: 708 HLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSL 766
H+AA H E V+ L+ +D L+ALH+AA H + + LL A+ N ++L
Sbjct: 337 HMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARAL 396
Score = 156 bits (395), Expect = 6e-38
Identities = 96/314 (30%), Positives = 160/314 (50%), Gaps = 2/314 (0%)
Query: 442 LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKD 501
LH+A G+ E + LL + A+P+ + G TPLH++ V +LL + +
Sbjct: 501 LHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLAT 560
Query: 502 EDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGV 561
+ +T LH AA+ G +LLL++ A+ + G TP+HVA + + + +LL +G
Sbjct: 561 KKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGA 620
Query: 562 DVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVAR 621
K+ + PLH AA + + I L G N T G TPLHLA+Q GH +
Sbjct: 621 SPHATAKNGYTPLHIAAKKNQMQIASTLLNY-GAETNIVTKQGVTPLHLASQEGHTDMVT 679
Query: 622 ILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNG 681
+L+D +++++ + T LH+AA+ + A +L GA ++A T GYT L +A G
Sbjct: 680 LLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYG 739
Query: 682 HLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALH 740
++ V L+++ A+V A+ T LH AA GH+ ++ L+ + G +AL
Sbjct: 740 NVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALA 799
Query: 741 LAAQGRHAQTVETL 754
+A + + V+TL
Sbjct: 800 IAKRLGYISVVDTL 813
Score = 110 bits (276), Expect = 4e-24
Identities = 87/298 (29%), Positives = 132/298 (44%), Gaps = 39/298 (13%)
Query: 500 KDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRR 559
K D + AA+ G+ L+ +N + G +H+A + G +V+ LL R
Sbjct: 27 KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86
Query: 560 GVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRV 619
G V K LH A+ G +VK+L K+ G ++NAQ+ +G TPL++AAQ H V
Sbjct: 87 GSSVDSATKKGNTALHIASLAGQAEVVKVLVKE-GANINAQSQNGFTPLYMAAQENHIDV 145
Query: 620 ARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLL-------------LHRGAGKE-- 664
+ L++ ++ + + TPL VA + GH +L LH A K+
Sbjct: 146 VKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDT 205
Query: 665 ----------------------AMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPL 702
T G+T LH+AA G++ LL+ A V
Sbjct: 206 KSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARN 265
Query: 703 NQTALHLAAAHGHSEVVEELVS-ADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGA 759
T LH+A+ G++ +V+ L+ ID GL+ LH AA+ H Q VE LL GA
Sbjct: 266 GITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGA 323
Score = 108 bits (269), Expect = 2e-23
Identities = 74/234 (31%), Positives = 116/234 (49%), Gaps = 3/234 (1%)
Query: 437 SGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKIS 496
+G + LH+A + Q + A LL A N+ ++G TPLH+A + +V LLL + +
Sbjct: 628 NGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGAN 687
Query: 497 VNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRIL 556
++ + T+LH AAQ + +L + A + G TP+ VAC +G +V L
Sbjct: 688 IHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFL 747
Query: 557 LRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGH 616
L++G +V+ + K+ + PLH AA QGH I+ +L Q G NA T +G T L +A + G+
Sbjct: 748 LKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLL-QHGAKPNATTANGNTALAIAKRLGY 806
Query: 617 YRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDG 670
V L + +V + T H T T L + G + MT DG
Sbjct: 807 ISVVDTLKVVTEEVTTTTTTI-TEKH-KLNVPETMTEVLDVSDEEGDDTMTGDG 858
Score = 70.5 bits (171), Expect = 6e-12
Identities = 44/160 (27%), Positives = 74/160 (46%)
Query: 430 DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVEL 489
+ ++ G + LHLA + G + LL AN ++S + G T LH+A + V ++
Sbjct: 654 ETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADI 713
Query: 490 LLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQ 549
L +A + +T L A G+ LL++ A+VN G TP+H A Q G
Sbjct: 714 LTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGH 773
Query: 550 ENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLL 589
+I+ +LL+ G + + L A G++ +V L
Sbjct: 774 THIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813
Score = 56.2 bits (134), Expect = 1e-07
Identities = 39/113 (34%), Positives = 58/113 (51%), Gaps = 4/113 (3%)
Query: 663 KEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEEL 722
K SD + AAR G+L V ++ D+ ALHLAA GH +V+EL
Sbjct: 24 KRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQEL 83
Query: 723 VS-ADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSLKFQGGHGP 774
+ +D ++G +ALH+A+ A+ V+ L++ GA+IN QS Q G P
Sbjct: 84 LGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQS---QNGFTP 133
Score = 30.0 bits (66), Expect = 8.6
Identities = 19/64 (29%), Positives = 29/64 (45%)
Query: 427 QPQDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGV 486
Q +V+ +G + LH A + G LL + A PN + G+T L +A V
Sbjct: 750 QGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISV 809
Query: 487 VELL 490
V+ L
Sbjct: 810 VDTL 813
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 179 bits (455), Expect = 7e-45
Identities = 109/326 (33%), Positives = 172/326 (52%), Gaps = 2/326 (0%)
Query: 438 GASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISV 497
G + LH+A AGQ E + LL N A + R TPLH+A +V+LLL
Sbjct: 464 GETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHP 523
Query: 498 NAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILL 557
+A + +T LH +A+ G +LLE A+ + +G TP+HVA ++G ++ ++LL
Sbjct: 524 DAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL 583
Query: 558 RRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHY 617
+R GK+ PLH AA + + LL ++ G S +A +G TPLH+AA++
Sbjct: 584 QRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEK-GASPHATAKNGYTPLHIAAKKNQM 642
Query: 618 RVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLA 677
++A L++ ++ N+ + TPLH+A++ GHT LLL +GA T G T+LHLA
Sbjct: 643 QIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLA 702
Query: 678 ARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGL 736
A+ + +L + AD A L T L +A +G+ ++V L+ ++ + G
Sbjct: 703 AQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGY 762
Query: 737 SALHLAAQGRHAQTVETLLRHGAHIN 762
+ LH AAQ H + LL+HGA N
Sbjct: 763 TPLHQAAQQGHTHIINVLLQHGAKPN 788
Score = 178 bits (451), Expect = 2e-44
Identities = 117/335 (34%), Positives = 176/335 (52%), Gaps = 3/335 (0%)
Query: 432 DLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLL 491
D+ LD + LH+A G K LL ANPN G TPLH+A ++ V+ELL+
Sbjct: 360 DVTLDY-LTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLV 418
Query: 492 ARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQEN 551
S+ A E T +H AA G + LLL+ AS + + G T +H+A + GQ
Sbjct: 419 KYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVE 478
Query: 552 IVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLA 611
+VR LLR G V + ++ PLH A+ G IV+LL Q +A T +G TPLH++
Sbjct: 479 VVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLL-QHMAHPDAATTNGYTPLHIS 537
Query: 612 AQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGY 671
A+ G VA +L++ + ++ + TPLHVAA+ G A+LLL R A ++ +G
Sbjct: 538 AREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGL 597
Query: 672 TALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDL 730
T LH+AA + LL+E+ A A T LH+AA ++ L++ ++
Sbjct: 598 TPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI 657
Query: 731 FDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQS 765
+QG++ LHLA+Q H V LL GA+I++ +
Sbjct: 658 VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMST 692
Score = 172 bits (435), Expect = 1e-42
Identities = 115/345 (33%), Positives = 176/345 (51%), Gaps = 3/345 (0%)
Query: 417 GDTSKLMKIL-QPQDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPL 475
G+T+ + +L + +D G + LH A +G ++ + LL A + G +PL
Sbjct: 277 GNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPL 336
Query: 476 HMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDF 535
HMA + V+ LL K V+ D TALH AA G T+LLL+K A+ N
Sbjct: 337 HMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARAL 396
Query: 536 EGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGV 595
G TP+H+AC+ + ++ +L++ G + + P+H AA+ GHL IV LL Q G
Sbjct: 397 NGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIV-LLLLQNGA 455
Query: 596 SVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARL 655
S + + G T LH+AA+ G V R L+ + V+ + QTPLH+A+ G T +L
Sbjct: 456 SPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQL 515
Query: 656 LLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGH 715
LL A +A T++GYT LH++AR G + +L+E A T LH+AA +G
Sbjct: 516 LLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGS 575
Query: 716 SEVVEELVS-ADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGA 759
+V + L+ D + GL+ LH+AA + + LL GA
Sbjct: 576 LDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGA 620
Score = 168 bits (425), Expect = 2e-41
Identities = 120/360 (33%), Positives = 189/360 (52%), Gaps = 13/360 (3%)
Query: 416 SGDTSKLMKILQPQ-DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTP 474
+G+ K+++ L+ D++ +G + LHLA + G + LL ++ + + ++G+T
Sbjct: 41 AGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTA 100
Query: 475 LHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVD 534
LH+A VV++L+ ++NA+ ++ +T L+ AAQ + LLE A+ +
Sbjct: 101 LHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTAT 160
Query: 535 FEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAK--- 591
+G TP+ VA Q G V ILL +GK LH AA + LL +
Sbjct: 161 EDGFTPLAVALQQGHNQAVAILLENDT----KGKVRLPALHIAARKDDTKSAALLLQNDH 216
Query: 592 ----QPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAET 647
Q + VN T G TPLH+AA G+ VA +L++ + V+ + TPLHVA++
Sbjct: 217 NADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKR 276
Query: 648 GHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTAL 707
G+T+ +LLL RG +A T DG T LH AAR+GH V+LL+E A +LAR + L
Sbjct: 277 GNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPL 336
Query: 708 HLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSL 766
H+AA H E V+ L+ +D L+ALH+AA H + + LL A+ N ++L
Sbjct: 337 HMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARAL 396
Score = 156 bits (395), Expect = 6e-38
Identities = 96/314 (30%), Positives = 160/314 (50%), Gaps = 2/314 (0%)
Query: 442 LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKD 501
LH+A G+ E + LL + A+P+ + G TPLH++ V +LL + +
Sbjct: 501 LHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLAT 560
Query: 502 EDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGV 561
+ +T LH AA+ G +LLL++ A+ + G TP+HVA + + + +LL +G
Sbjct: 561 KKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGA 620
Query: 562 DVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVAR 621
K+ + PLH AA + + I L G N T G TPLHLA+Q GH +
Sbjct: 621 SPHATAKNGYTPLHIAAKKNQMQIASTLLNY-GAETNIVTKQGVTPLHLASQEGHTDMVT 679
Query: 622 ILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNG 681
+L+D +++++ + T LH+AA+ + A +L GA ++A T GYT L +A G
Sbjct: 680 LLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYG 739
Query: 682 HLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALH 740
++ V L+++ A+V A+ T LH AA GH+ ++ L+ + G +AL
Sbjct: 740 NVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALA 799
Query: 741 LAAQGRHAQTVETL 754
+A + + V+TL
Sbjct: 800 IAKRLGYISVVDTL 813
Score = 110 bits (276), Expect = 4e-24
Identities = 87/298 (29%), Positives = 132/298 (44%), Gaps = 39/298 (13%)
Query: 500 KDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRR 559
K D + AA+ G+ L+ +N + G +H+A + G +V+ LL R
Sbjct: 27 KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86
Query: 560 GVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRV 619
G V K LH A+ G +VK+L K+ G ++NAQ+ +G TPL++AAQ H V
Sbjct: 87 GSSVDSATKKGNTALHIASLAGQAEVVKVLVKE-GANINAQSQNGFTPLYMAAQENHIDV 145
Query: 620 ARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLL-------------LHRGAGKE-- 664
+ L++ ++ + + TPL VA + GH +L LH A K+
Sbjct: 146 VKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDT 205
Query: 665 ----------------------AMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPL 702
T G+T LH+AA G++ LL+ A V
Sbjct: 206 KSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARN 265
Query: 703 NQTALHLAAAHGHSEVVEELVS-ADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGA 759
T LH+A+ G++ +V+ L+ ID GL+ LH AA+ H Q VE LL GA
Sbjct: 266 GITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGA 323
Score = 108 bits (269), Expect = 2e-23
Identities = 74/234 (31%), Positives = 116/234 (49%), Gaps = 3/234 (1%)
Query: 437 SGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKIS 496
+G + LH+A + Q + A LL A N+ ++G TPLH+A + +V LLL + +
Sbjct: 628 NGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGAN 687
Query: 497 VNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRIL 556
++ + T+LH AAQ + +L + A + G TP+ VAC +G +V L
Sbjct: 688 IHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFL 747
Query: 557 LRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGH 616
L++G +V+ + K+ + PLH AA QGH I+ +L Q G NA T +G T L +A + G+
Sbjct: 748 LKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLL-QHGAKPNATTANGNTALAIAKRLGY 806
Query: 617 YRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDG 670
V L + +V + T H T T L + G + MT DG
Sbjct: 807 ISVVDTLKVVTEEVTTTTTTI-TEKH-KLNVPETMTEVLDVSDEEGDDTMTGDG 858
Score = 70.5 bits (171), Expect = 6e-12
Identities = 44/160 (27%), Positives = 74/160 (46%)
Query: 430 DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVEL 489
+ ++ G + LHLA + G + LL AN ++S + G T LH+A + V ++
Sbjct: 654 ETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADI 713
Query: 490 LLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQ 549
L +A + +T L A G+ LL++ A+VN G TP+H A Q G
Sbjct: 714 LTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGH 773
Query: 550 ENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLL 589
+I+ +LL+ G + + L A G++ +V L
Sbjct: 774 THIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813
Score = 56.2 bits (134), Expect = 1e-07
Identities = 39/113 (34%), Positives = 58/113 (51%), Gaps = 4/113 (3%)
Query: 663 KEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEEL 722
K SD + AAR G+L V ++ D+ ALHLAA GH +V+EL
Sbjct: 24 KRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQEL 83
Query: 723 VS-ADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSLKFQGGHGP 774
+ +D ++G +ALH+A+ A+ V+ L++ GA+IN QS Q G P
Sbjct: 84 LGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQS---QNGFTP 133
Score = 30.0 bits (66), Expect = 8.6
Identities = 19/64 (29%), Positives = 29/64 (45%)
Query: 427 QPQDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGV 486
Q +V+ +G + LH A + G LL + A PN + G+T L +A V
Sbjct: 750 QGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISV 809
Query: 487 VELL 490
V+ L
Sbjct: 810 VDTL 813
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 172 bits (436), Expect = 1e-42
Identities = 111/339 (32%), Positives = 171/339 (50%), Gaps = 3/339 (0%)
Query: 423 MKILQPQDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERR 482
M I + +DV+ + LH+A G E + L+L+ A N + TPLH AV R
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
Query: 483 VRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMH 542
V++L+ VNA+D++ T LH AA N +++ +SVN D GRT +H
Sbjct: 61 SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120
Query: 543 VACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTL 602
A +G +V +LL +G +++ K LH+AA+ GHL +V LL G V +
Sbjct: 121 HAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINH-GAEVTCKDK 179
Query: 603 DGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAG 662
G TPLH AA G V + L++L +++ ++ T LH+A G + L+ GA
Sbjct: 180 KGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGAN 239
Query: 663 KEAMTSDGYTALHLAARNGHLA-TVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEE 721
++G+T LH AA + H A ++LLV ADV + ++ LH+ A HG +
Sbjct: 240 VNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQT 299
Query: 722 LV-SADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGA 759
L+ + ID D+ G + LH+AA+ H + TL GA
Sbjct: 300 LIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGA 338
Score = 166 bits (419), Expect = 1e-40
Identities = 110/369 (29%), Positives = 172/369 (46%), Gaps = 3/369 (0%)
Query: 397 TSDLGTTDVQKKKLVDAIVSGDTSKLMKILQP--QDVDLALDSGASLLHLAVEAGQEECA 454
++D+ D + + + K +++ P V+++ G + LH A G E
Sbjct: 72 SADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMV 131
Query: 455 KWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQN 514
LL AN N +++ LH A VV LL+ V KD+ +T LH AA N
Sbjct: 132 NLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASN 191
Query: 515 GDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPL 574
G + + LL ++E++ G T +H+AC +GQ+ +V L+ G +V+ + + PL
Sbjct: 192 GQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPL 251
Query: 575 HYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCS 634
H+AA H + L G VN Q+ DG++PLH+ A G + ++ LI +++
Sbjct: 252 HFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVD 311
Query: 635 LLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKA 694
TPLHVAA GH L GA LHLAA N H + L+
Sbjct: 312 KDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGF 371
Query: 695 DVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVET 753
++ +T LH AAA G+ E ++ L S+ D+ G + LH AA H +ET
Sbjct: 372 EIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIET 431
Query: 754 LLRHGAHIN 762
L+ GA++N
Sbjct: 432 LVTTGANVN 440
Score = 144 bits (364), Expect = 2e-34
Identities = 110/397 (27%), Positives = 178/397 (44%), Gaps = 41/397 (10%)
Query: 399 DLGTTDVQKKKLVDAIVSGDTSKLMKILQPQDVDLALDS--GASLLHLAVEAGQEECAKW 456
++ T D + + A +G + +K+LQ D G + LH A C +
Sbjct: 372 EIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIET 431
Query: 457 LLLNNANPNLSNRRGSTPLHMAV----------------------------ERRVRGVVE 488
L+ AN N ++ G T LH A E+ +E
Sbjct: 432 LVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLE 491
Query: 489 LLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRT--PMHVACQ 546
LL + + +D++ + ++H+AA G LLLE+ S E G T P+H+A
Sbjct: 492 FLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAY 551
Query: 547 HGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQ-TLDGR 605
+G + +LL+ VD+ ++ + L AA++GH V+ L PG S+ + + R
Sbjct: 552 NGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALIN-PGASIFVKDNVTKR 610
Query: 606 TPLHLAAQRGHYRVARILIDLCSD---VNVCSLLAQTPLHVAAETGHTSTARLLLHRGAG 662
TPLH + GH R+L+++ + V+V QTPL +A GH LLL + A
Sbjct: 611 TPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEAN 670
Query: 663 KEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGH----SEV 718
+ + G TALH GH V++L+E++ +L + +T LH AAA GH SE+
Sbjct: 671 VDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSEL 730
Query: 719 VEELVSADVIDLFDEQGLSALHLAAQGRHAQTVETLL 755
++ +S + D QG + LH A + +E LL
Sbjct: 731 LQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLL 767
Score = 139 bits (350), Expect = 1e-32
Identities = 111/389 (28%), Positives = 167/389 (42%), Gaps = 66/389 (16%)
Query: 438 GASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGV-VELLLARKIS 496
G + LH+A GQ+ L+ AN N N G TPLH A + +ELL+
Sbjct: 214 GNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGAD 273
Query: 497 VNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRIL 556
VN + +D + LH A +G + ++ L++ ++ VD +G TP+HVA ++G E ++ L
Sbjct: 274 VNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTL 333
Query: 557 LRRGVDVSLQGKDAWLPLHYAAWQGH---------------------------------L 583
G D + G + PLH AA H +
Sbjct: 334 RTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNV 393
Query: 584 PIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHV 643
+KLL + G + + GRTPLH AA H+ L+ ++VN +T LH
Sbjct: 394 ECIKLL-QSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHY 452
Query: 644 AAET-----------GHTSTARL-----------------LLHRGAGKEAMTSDGYTALH 675
AA + H ++ L LL A +GY ++H
Sbjct: 453 AAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIH 512
Query: 676 LAARNGHLATVKLLVEEKADVLARGPLNQTA--LHLAAAHGHSEVVEELVSADV-IDLFD 732
AA GH ++LL+E T LHLAA +GH + +E L+ + V +D+ D
Sbjct: 513 YAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRD 572
Query: 733 EQGLSALHLAAQGRHAQTVETLLRHGAHI 761
E+G +AL LAA H + VE L+ GA I
Sbjct: 573 EKGRTALDLAAFKGHTECVEALINPGASI 601
Score = 135 bits (339), Expect = 2e-31
Identities = 116/363 (31%), Positives = 169/363 (46%), Gaps = 38/363 (10%)
Query: 430 DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVEL 489
++D G + LH A G EC K L + A+ + ++ G TPLH A +E
Sbjct: 372 EIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIET 431
Query: 490 LLARKISVNAKDEDQWTALHFAAQ-----------NGDESSTRL---------------- 522
L+ +VN D+ TALH+AA N ++S L
Sbjct: 432 LVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLE 491
Query: 523 -LLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRR---GVDVSLQGKDAWLPLHYAA 578
LL+ +A+ + D EG +H A +G + +LL R G + S G PLH AA
Sbjct: 492 FLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATK-SPLHLAA 550
Query: 579 WQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNV-CSLLA 637
+ GH +++L Q V ++ + GRT L LAA +GH LI+ + + V ++
Sbjct: 551 YNGHHQALEVLL-QSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTK 609
Query: 638 QTPLHVAAETGHTSTARLLLHRGAGKEAM---TSDGYTALHLAARNGHLATVKLLVEEKA 694
+TPLH + GHT RLLL EA+ + G T L LA GH+ V LL+E++A
Sbjct: 610 RTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEA 669
Query: 695 DVLARGPLNQTALHLAAAHGHSEVVEELVSADVIDLF-DEQGLSALHLAAQGRHAQTVET 753
+V L TALH GH E V+ L+ +V L D +G + LH AA HA +
Sbjct: 670 NVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSE 729
Query: 754 LLR 756
LL+
Sbjct: 730 LLQ 732
Score = 123 bits (309), Expect = 6e-28
Identities = 103/348 (29%), Positives = 151/348 (43%), Gaps = 31/348 (8%)
Query: 438 GASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISV 497
G + LH A GQ K LL + N G+T LH+A VV L+ +V
Sbjct: 181 GYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANV 240
Query: 498 NAKDEDQWTALHFAAQNGDES-STRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRIL 556
N + + +T LHFAA + + LL+ A VN +G++P+H+ HG+ + L
Sbjct: 241 NQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTL 300
Query: 557 LRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGH 616
++ G ++ KD PLH AA GH ++ L + G + PLHLAA H
Sbjct: 301 IQNGGEIDCVDKDGNTPLHVAARYGHELLINTL-RTSGADTAKCGIHSMFPLHLAALNAH 359
Query: 617 YRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHL 676
R L+ +++ +T LH AA G+ +LL GA G T LH
Sbjct: 360 SDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHY 419
Query: 677 AARNGHLATVKLLVEEKADVLARGPLNQTALHLAA-------------AHGHSEVVE--- 720
AA N H ++ LV A+V +TALH AA AH +SE +E
Sbjct: 420 AAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERAR 479
Query: 721 ELVSADVI-------------DLFDEQGLSALHLAAQGRHAQTVETLL 755
EL + + D++G +++H AA H Q +E LL
Sbjct: 480 ELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLL 527
Score = 119 bits (297), Expect = 1e-26
Identities = 94/354 (26%), Positives = 153/354 (43%), Gaps = 45/354 (12%)
Query: 453 CAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTA--LHF 510
C ++LL N+ANP++ ++ G +H A R +ELLL R S + + T LH
Sbjct: 489 CLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHL 548
Query: 511 AAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGK-D 569
AA NG + +LL+ ++ D +GRT + +A G V L+ G + ++
Sbjct: 549 AAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVT 608
Query: 570 AWLPLHYAAWQGHLPIVKLL---AKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDL 626
PLH + GH ++LL A P +V+ + G+TPL LA GH +L++
Sbjct: 609 KRTPLHASVINGHTLCLRLLLEIADNPE-AVDVKDAKGQTPLMLAVAYGHIDAVSLLLEK 667
Query: 627 CSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATV 686
++V+ +L T LH TGH ++LL + S G T LH AA GH +
Sbjct: 668 EANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWL 727
Query: 687 KLLVE---EKADVLARGPLNQTALHLAAAHGHSEVVEEL--------------------- 722
L++ + D + T LH A +G+ +E L
Sbjct: 728 SELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPFTPLHCAI 787
Query: 723 --------------VSADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHIN 762
+ + ++ D++G + L AA H + ++ LLRH A +N
Sbjct: 788 INDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVN 841
Score = 119 bits (297), Expect = 1e-26
Identities = 115/385 (29%), Positives = 161/385 (41%), Gaps = 50/385 (12%)
Query: 379 SAFSSRGSLSLSFEREPSTSDLGTTDVQKKKLVDAIVSGDTSKLMKILQPQ-DVDLALDS 437
+A+ R L L ER S + + K L A +G L +LQ D+D+ +
Sbjct: 515 AAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEK 574
Query: 438 GASLLHLAVEAGQEECAKWLLLNNANPNLS-----NRRGSTPLHMAVERRVRGVVELLLA 492
G + L LA G EC + L+ NP S N TPLH +V + LLL
Sbjct: 575 GRTALDLAAFKGHTECVEALI----NPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLE 630
Query: 493 ---RKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQ 549
+V+ KD T L A G + LLLEK A+V+ VD G T +H G
Sbjct: 631 IADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGH 690
Query: 550 ENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLD--GRTP 607
E V++LL + V + + PLHYAA +GH + L + + D G TP
Sbjct: 691 EECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTP 750
Query: 608 LHLAAQRGHYRVARILIDL---------------CSDVN----VCSLL------------ 636
LH A G+ +L++ C+ +N SLL
Sbjct: 751 LHWACYNGNENCIEVLLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCR 810
Query: 637 ---AQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEE- 692
+TPL AA H +LLL A A+ + G TAL +AA NG V +LV
Sbjct: 811 DDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSA 870
Query: 693 KADVLARGPLNQTALHLAAAHGHSE 717
+AD+ + T LHLA + GH +
Sbjct: 871 QADLTVKDKDLNTPLHLACSKGHEK 895
Score = 105 bits (263), Expect = 1e-22
Identities = 92/311 (29%), Positives = 140/311 (45%), Gaps = 11/311 (3%)
Query: 395 PSTSDLGTTDVQKKKLVDA-IVSGDTSKLMKILQ----PQDVDLALDSGASLLHLAVEAG 449
P S +V K+ + A +++G T L +L+ P+ VD+ G + L LAV G
Sbjct: 597 PGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYG 656
Query: 450 QEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALH 509
+ LL AN + + G T LH + V++LL +++S+ KD T LH
Sbjct: 657 HIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLH 716
Query: 510 FAAQNGDESSTRLLLEKNASVNEV---DFEGRTPMHVACQHGQENIVRILLRRGVDVSLQ 566
+AA G + LL+ S + D +G TP+H AC +G EN + +LL +
Sbjct: 717 YAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFI 776
Query: 567 GKDAWLPLHYAAWQGHLPIVKLLAKQPGVS-VNAQTLDGRTPLHLAAQRGHYRVARILID 625
G + + PLH A H LL S V+ + GRTPL AA H ++L+
Sbjct: 777 G-NPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLR 835
Query: 626 LCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRG-AGKEAMTSDGYTALHLAARNGHLA 684
+ VN +T L +AAE G +L++ A D T LHLA GH
Sbjct: 836 HSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEK 895
Query: 685 TVKLLVEEKAD 695
L++++ D
Sbjct: 896 CALLILDKIQD 906
Score = 98.6 bits (244), Expect = 2e-20
Identities = 90/369 (24%), Positives = 148/369 (40%), Gaps = 38/369 (10%)
Query: 430 DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVEL 489
++D G + LH+A G E L + A+ PLH+A
Sbjct: 306 EIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRK 365
Query: 490 LLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQ 549
LL+ ++ D+ T LH AA G+ +LL A ++ D GRTP+H A +
Sbjct: 366 LLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCH 425
Query: 550 ENIVRILLRRGVDVSLQGKDAWLPLHYAA-----------------------------WQ 580
+ + L+ G +V+ LHYAA +
Sbjct: 426 FHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKE 485
Query: 581 GHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSD--VNVCSLLAQ 638
L + LL S+ + +G +H AA GH + +L++ + S +
Sbjct: 486 ATLCLEFLLQNDANPSIRDK--EGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATK 543
Query: 639 TPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLA 698
+PLH+AA GH +LL + G TAL LAA GH V+ L+ A +
Sbjct: 544 SPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFV 603
Query: 699 RGPL-NQTALHLAAAHGHSEVVEELV----SADVIDLFDEQGLSALHLAAQGRHAQTVET 753
+ + +T LH + +GH+ + L+ + + +D+ D +G + L LA H V
Sbjct: 604 KDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSL 663
Query: 754 LLRHGAHIN 762
LL A+++
Sbjct: 664 LLEKEANVD 672
Score = 81.6 bits (200), Expect = 3e-15
Identities = 55/172 (31%), Positives = 84/172 (48%), Gaps = 1/172 (0%)
Query: 597 VNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLL 656
VN + RTPLH+AA G + +LI + VN + TPLH A + ++L
Sbjct: 9 VNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVL 68
Query: 657 LHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHS 716
+ A A + T LH+AA N + ++++ + V +TALH AA +GH
Sbjct: 69 IKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHV 128
Query: 717 EVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSLK 767
E+V L++ I+ FD++ ALH AA H V L+ HGA + + K
Sbjct: 129 EMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKK 180
Score = 56.6 bits (135), Expect = 9e-08
Identities = 40/127 (31%), Positives = 61/127 (48%), Gaps = 3/127 (2%)
Query: 442 LHLAVEAGQEECAKWLL--LNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNA 499
LH A+ CA LL ++++ + + +G TPL A ++LLL VNA
Sbjct: 783 LHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNA 842
Query: 500 KDEDQWTALHFAAQNGDESSTRLLLEK-NASVNEVDFEGRTPMHVACQHGQENIVRILLR 558
D TAL AA+NG + +L+ A + D + TP+H+AC G E ++L
Sbjct: 843 VDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILD 902
Query: 559 RGVDVSL 565
+ D SL
Sbjct: 903 KIQDESL 909
Score = 45.4 bits (106), Expect = 2e-04
Identities = 25/83 (30%), Positives = 44/83 (53%), Gaps = 1/83 (1%)
Query: 688 LLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELV-SADVIDLFDEQGLSALHLAAQGR 746
+L+ + DV +T LH+AA G +E++E L+ S ++ D L+ LH A R
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
Query: 747 HAQTVETLLRHGAHINLQSLKFQ 769
+ V+ L++H A +N + +Q
Sbjct: 61 SEEAVQVLIKHSADVNARDKNWQ 83
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
sapiens]
Length = 2603
Score = 167 bits (423), Expect = 3e-41
Identities = 150/448 (33%), Positives = 221/448 (49%), Gaps = 30/448 (6%)
Query: 335 LLSQLDSGVSQAVEGPEELSRSSSESKLPSSGSGKR-------------LSGVSSVDSAF 381
LLS G PE +R E+ L ++G GK L ++S S
Sbjct: 154 LLSGTADGADLRTVDPETQARL--EALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCA 211
Query: 382 SSRGSLSLSFEREPSTSDLGTTDVQKKKLVDAIVSGDTSKLMKIL-QPQDVDLALDSGAS 440
+ +L+ R ST++ G +D + L +A GD + + K+L + + V+ + G S
Sbjct: 212 LDEAAAALTRMRAESTANAGQSD--NRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGES 269
Query: 441 LLHLAVEAGQEECAKWLLLNNANPNLSNRRGS-TPLHMAVERRVRGVVELLLARKISVNA 499
LL LA AG E A+ LL +AN +G TPL A +V+LLLA K VNA
Sbjct: 270 LLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNA 329
Query: 500 KDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRR 559
+ TAL +A G ++LLE AS+ + + G TP+ A G + R+LL
Sbjct: 330 QSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLEN 389
Query: 560 GVDVSLQG---KDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGH 616
G ++ K++ L L A ++GHL +V+ L + G +T + T L A GH
Sbjct: 390 GAGINTHSNEFKESALTL--ACYKGHLEMVRFLL-EAGADQEHKTDEMHTALMEACMDGH 446
Query: 617 YRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHL 676
VAR+L+D + VN+ + ++PL +AA GH A LL+ RGA E + +GYT L
Sbjct: 447 VEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLME 506
Query: 677 AARNGHLATVKLLVEEKADVLARGPLNQ-TALHLAAAHGHSEVVEELVSADVIDLFDEQG 735
AAR GH V LL+ + A++ A+ Q TAL LA G EV + L+ A D+ E G
Sbjct: 507 AAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGA-DI--ELG 563
Query: 736 LSA-LHLAAQGRHAQTVETLLRHGAHIN 762
S L AAQ H + V+ LL GA+++
Sbjct: 564 CSTPLMEAAQEGHLELVKYLLAAGANVH 591
Score = 136 bits (343), Expect = 7e-32
Identities = 140/481 (29%), Positives = 218/481 (45%), Gaps = 28/481 (5%)
Query: 292 DEVKETAHDLDVKSPPEPRSEVVPARLKRASAPTFDNDYS-LSELLSQLDSGVSQAVEGP 350
DE ++TA + +P +P + +P L A+ P + L+EL + V Q V G
Sbjct: 939 DEPQQTAAQMGF-APIQPLA--MPQALPLAAGPLPPGSIANLTELQGVI---VGQPVLGQ 992
Query: 351 EELS-------RSSSESKLPSSGSGKRLSGVSSVDSAFSSRGSLSLSFEREPSTSDLGTT 403
+L+ + + + +S + + + +A S R S + P+ S +
Sbjct: 993 AQLAGLGQGILTETQQGLMVASPAQTLNDTLDDIMAAVSGRAS---AMSNTPTHSIAASI 1049
Query: 404 DVQKKKLVDAIVSGDTSKLMKILQPQDVDLALDSGA-SLLHLAVEAGQEECAKWLLLNNA 462
+ I+S S ++ I D+D +S + L LA G EE + LL A
Sbjct: 1050 SQPQTPTPSPIIS--PSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGA 1107
Query: 463 NPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDE-DQWTALHFAAQNGDESSTR 521
+ +++G TPL +A GVVE+LL + A+ E + T L A G +
Sbjct: 1108 SIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVE 1167
Query: 522 LLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQ--GKDAWLPLHYAAW 579
LLL + A+ + TP+ +A G NI++ILL G +++ + K PL AA
Sbjct: 1168 LLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAM 1227
Query: 580 QGHLPIVKLLAKQPGVSVNAQTLDGR-TPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQ 638
GH VKLL G +NAQ R T L LA +G V +L+D ++V +
Sbjct: 1228 NGHTAAVKLLLDM-GSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGL 1286
Query: 639 TPLHVAAETGHTSTARLLLHRGAGKEA--MTSDGYTALHLAARNGHLATVKLLVEEKADV 696
TPL AA G+ R+LL +GA A + S TAL +AA GH +LL+ A +
Sbjct: 1287 TPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHI 1346
Query: 697 LARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLL 755
R T L LAA GH +VV+ LV A +D D + ++ L A + H + V L+
Sbjct: 1347 DVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLV 1406
Query: 756 R 756
+
Sbjct: 1407 K 1407
Score = 131 bits (330), Expect = 2e-30
Identities = 117/344 (34%), Positives = 159/344 (46%), Gaps = 20/344 (5%)
Query: 431 VDLALDSGASL----------LHLAVEAGQEECAKWLLLNNANPNL-SNRRGSTPLHMAV 479
V + L+SGAS+ L A AG E A+ LL N A N SN + L +A
Sbjct: 350 VKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLAC 409
Query: 480 ERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRT 539
+ +V LL K ++ TAL A +G RLLL+ A VN +
Sbjct: 410 YKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFES 469
Query: 540 PMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNA 599
P+ +A G + +L+ RG + + + PL AA +GH +V LL Q G ++NA
Sbjct: 470 PLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQ-GANINA 528
Query: 600 QTLDGR-TPLHLAAQRGHYRVARILIDLCSDVNV-CSLLAQTPLHVAAETGHTSTARLLL 657
QT + + T L LA G VA LI +D+ + CS TPL AA+ GH + LL
Sbjct: 529 QTEETQETALTLACCGGFLEVADFLIKAGADIELGCS----TPLMEAAQEGHLELVKYLL 584
Query: 658 HRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSE 717
GA A T+ G TAL A NGH +L++ AD+ +T L AA GH
Sbjct: 585 AAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVC 644
Query: 718 VVEELVS--ADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGA 759
V+ L+S A+V + L LA G H VE LL HGA
Sbjct: 645 TVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGA 688
Score = 126 bits (316), Expect = 9e-29
Identities = 95/297 (31%), Positives = 148/297 (49%), Gaps = 8/297 (2%)
Query: 473 TPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNE 532
T L +A +V+ LL R S+ +D+ +T L AA G +LL+ A +
Sbjct: 1085 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 1144
Query: 533 VDFEGR-TPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAK 591
+ TP+ +AC G++ +V +LL RG + + + PL AA G++ I+K+L
Sbjct: 1145 QSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1204
Query: 592 QPGVSVNAQTLD--GRTPLHLAAQRGHYRVARILIDLCSDVNV-CSLLAQTPLHVAAETG 648
G +N++T G +PL LAA GH ++L+D+ SD+N T L +A G
Sbjct: 1205 A-GAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQG 1263
Query: 649 HTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARG--PLNQTA 706
T LLL R A E G T L AA G+ ++L+++ ADV A TA
Sbjct: 1264 RTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTA 1323
Query: 707 LHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHIN 762
L +AA GH + E L+ ID+ +++G + L LAA G H V+ L++ GA ++
Sbjct: 1324 LTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVD 1380
Score = 118 bits (296), Expect = 2e-26
Identities = 102/303 (33%), Positives = 150/303 (49%), Gaps = 21/303 (6%)
Query: 495 ISVNAKDEDQW-TALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIV 553
I ++A+ E TAL A G E + LLE+ AS+ D +G TP+ +A G +V
Sbjct: 1073 IDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVV 1132
Query: 554 RILLRRGVDVSLQG---KDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHL 610
ILL G D+ Q KD PL A G +V+LL + G + + + TPL L
Sbjct: 1133 EILLDNGADIEAQSERTKDT--PLSLACSGGRQEVVELLLAR-GANKEHRNVSDYTPLSL 1189
Query: 611 AAQRGHYRVARILIDLCSDVN--VCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEA-MT 667
AA G+ + +IL++ +++N S L +PL +AA GHT+ +LLL G+ A +
Sbjct: 1190 AASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIE 1249
Query: 668 SDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELV--SA 725
++ TAL LA G V LL++ KA+V R T L AA+ G++EV L+ A
Sbjct: 1250 TNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGA 1309
Query: 726 DV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQS--------LKFQGGHGPAA 776
DV +AL +AA H + E L+ GAHI++++ L GGH
Sbjct: 1310 DVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVV 1369
Query: 777 TLL 779
LL
Sbjct: 1370 QLL 1372
Score = 118 bits (295), Expect = 2e-26
Identities = 83/278 (29%), Positives = 138/278 (49%), Gaps = 17/278 (6%)
Query: 431 VDLALDSGASL-----------LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAV 479
V++ LD+GA + L LA G++E + LL AN N TPL +A
Sbjct: 1132 VEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAA 1191
Query: 480 ERRVRGVVELLLARKISVNAKDEDQW--TALHFAAQNGDESSTRLLLEKNASVN-EVDFE 536
++++LL +N++ + + L AA NG ++ +LLL+ + +N +++
Sbjct: 1192 SGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETN 1251
Query: 537 GRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVS 596
T + +AC G+ +V +LL R +V + K PL AA G+ + ++L + G
Sbjct: 1252 RNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDK-GAD 1310
Query: 597 VNAQTLDGR--TPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTAR 654
VNA + T L +AA +GHY+ +LI + ++V + TPL +AA GH +
Sbjct: 1311 VNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQ 1370
Query: 655 LLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEE 692
LL+ GA +A + T L A R GH+ V+ LV+E
Sbjct: 1371 LLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE 1408
Score = 106 bits (264), Expect = 9e-23
Identities = 94/308 (30%), Positives = 137/308 (44%), Gaps = 7/308 (2%)
Query: 403 TDVQKKKLVDAIVSGDTSKLMKILQP-QDVDLALDSGASLLHLAVEAGQEECAKWLLLNN 461
TD L++A + G +L V++ DS S L LA G E A L+
Sbjct: 431 TDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERG 490
Query: 462 ANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDED-QWTALHFAAQNGDESST 520
A+ N G TPL A +V LLL + ++NA+ E+ Q TAL A G
Sbjct: 491 ASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVA 550
Query: 521 RLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQ 580
L++ A +++ TP+ A Q G +V+ LL G +V L YA
Sbjct: 551 DFLIKAGA---DIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACEN 607
Query: 581 GHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVN-VCSLLAQT 639
GH + +L Q G + ++ GRTPL AA+ GH + LI ++VN + T
Sbjct: 608 GHTDVADVLL-QAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHT 666
Query: 640 PLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLAR 699
L +A GH + LLL GA DG T L AA+ GH + V L++ ++L+
Sbjct: 667 VLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSA 726
Query: 700 GPLNQTAL 707
P + T L
Sbjct: 727 PPPDVTQL 734
Score = 67.8 bits (164), Expect = 4e-11
Identities = 58/176 (32%), Positives = 83/176 (47%), Gaps = 3/176 (1%)
Query: 596 SVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARL 655
+ NA D R+ L A G R L+ VN + ++ L +A G+ A++
Sbjct: 227 TANAGQSDNRS-LAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQV 285
Query: 656 LLHRGAGKEAMTSDG-YTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHG 714
LL A E G T L AA GH+ VKLL+ KADV A+ TAL A A G
Sbjct: 286 LLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGG 345
Query: 715 HSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSLKFQ 769
+ +VV+ L+ + I+ +E G + L A H + LL +GA IN S +F+
Sbjct: 346 YVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFK 401
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo
sapiens]
Length = 2352
Score = 167 bits (423), Expect = 3e-41
Identities = 150/448 (33%), Positives = 221/448 (49%), Gaps = 30/448 (6%)
Query: 335 LLSQLDSGVSQAVEGPEELSRSSSESKLPSSGSGKR-------------LSGVSSVDSAF 381
LLS G PE +R E+ L ++G GK L ++S S
Sbjct: 154 LLSGTADGADLRTVDPETQARL--EALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCA 211
Query: 382 SSRGSLSLSFEREPSTSDLGTTDVQKKKLVDAIVSGDTSKLMKIL-QPQDVDLALDSGAS 440
+ +L+ R ST++ G +D + L +A GD + + K+L + + V+ + G S
Sbjct: 212 LDEAAAALTRMRAESTANAGQSD--NRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGES 269
Query: 441 LLHLAVEAGQEECAKWLLLNNANPNLSNRRGS-TPLHMAVERRVRGVVELLLARKISVNA 499
LL LA AG E A+ LL +AN +G TPL A +V+LLLA K VNA
Sbjct: 270 LLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNA 329
Query: 500 KDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRR 559
+ TAL +A G ++LLE AS+ + + G TP+ A G + R+LL
Sbjct: 330 QSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLEN 389
Query: 560 GVDVSLQG---KDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGH 616
G ++ K++ L L A ++GHL +V+ L + G +T + T L A GH
Sbjct: 390 GAGINTHSNEFKESALTL--ACYKGHLEMVRFLL-EAGADQEHKTDEMHTALMEACMDGH 446
Query: 617 YRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHL 676
VAR+L+D + VN+ + ++PL +AA GH A LL+ RGA E + +GYT L
Sbjct: 447 VEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLME 506
Query: 677 AARNGHLATVKLLVEEKADVLARGPLNQ-TALHLAAAHGHSEVVEELVSADVIDLFDEQG 735
AAR GH V LL+ + A++ A+ Q TAL LA G EV + L+ A D+ E G
Sbjct: 507 AAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGA-DI--ELG 563
Query: 736 LSA-LHLAAQGRHAQTVETLLRHGAHIN 762
S L AAQ H + V+ LL GA+++
Sbjct: 564 CSTPLMEAAQEGHLELVKYLLAAGANVH 591
Score = 136 bits (342), Expect = 9e-32
Identities = 113/345 (32%), Positives = 165/345 (47%), Gaps = 9/345 (2%)
Query: 420 SKLMKILQPQDVDLALDSGA-SLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMA 478
S ++ I D+D +S + L LA G EE + LL A+ +++G TPL +A
Sbjct: 813 SAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILA 872
Query: 479 VERRVRGVVELLLARKISVNAKDE-DQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEG 537
GVVE+LL + A+ E + T L A G + LLL + A+ +
Sbjct: 873 ATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSD 932
Query: 538 RTPMHVACQHGQENIVRILLRRGVDVSLQ--GKDAWLPLHYAAWQGHLPIVKLLAKQPGV 595
TP+ +A G NI++ILL G +++ + K PL AA GH VKLL G
Sbjct: 933 YTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDM-GS 991
Query: 596 SVNAQTLDGR-TPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTAR 654
+NAQ R T L LA +G V +L+D ++V + TPL AA G+ R
Sbjct: 992 DINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGR 1051
Query: 655 LLLHRGAGKEA--MTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAA 712
+LL +GA A + S TAL +AA GH +LL+ A + R T L LAA
Sbjct: 1052 VLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAAN 1111
Query: 713 HGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLR 756
GH +VV+ LV A +D D + ++ L A + H + V L++
Sbjct: 1112 GGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1156
Score = 131 bits (330), Expect = 2e-30
Identities = 117/344 (34%), Positives = 159/344 (46%), Gaps = 20/344 (5%)
Query: 431 VDLALDSGASL----------LHLAVEAGQEECAKWLLLNNANPNL-SNRRGSTPLHMAV 479
V + L+SGAS+ L A AG E A+ LL N A N SN + L +A
Sbjct: 350 VKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLAC 409
Query: 480 ERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRT 539
+ +V LL K ++ TAL A +G RLLL+ A VN +
Sbjct: 410 YKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFES 469
Query: 540 PMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNA 599
P+ +A G + +L+ RG + + + PL AA +GH +V LL Q G ++NA
Sbjct: 470 PLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQ-GANINA 528
Query: 600 QTLDGR-TPLHLAAQRGHYRVARILIDLCSDVNV-CSLLAQTPLHVAAETGHTSTARLLL 657
QT + + T L LA G VA LI +D+ + CS TPL AA+ GH + LL
Sbjct: 529 QTEETQETALTLACCGGFLEVADFLIKAGADIELGCS----TPLMEAAQEGHLELVKYLL 584
Query: 658 HRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSE 717
GA A T+ G TAL A NGH +L++ AD+ +T L AA GH
Sbjct: 585 AAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVC 644
Query: 718 VVEELVS--ADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGA 759
V+ L+S A+V + L LA G H VE LL HGA
Sbjct: 645 TVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGA 688
Score = 126 bits (316), Expect = 9e-29
Identities = 95/297 (31%), Positives = 148/297 (49%), Gaps = 8/297 (2%)
Query: 473 TPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNE 532
T L +A +V+ LL R S+ +D+ +T L AA G +LL+ A +
Sbjct: 834 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 893
Query: 533 VDFEGR-TPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAK 591
+ TP+ +AC G++ +V +LL RG + + + PL AA G++ I+K+L
Sbjct: 894 QSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 953
Query: 592 QPGVSVNAQTLD--GRTPLHLAAQRGHYRVARILIDLCSDVNV-CSLLAQTPLHVAAETG 648
G +N++T G +PL LAA GH ++L+D+ SD+N T L +A G
Sbjct: 954 A-GAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQG 1012
Query: 649 HTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARG--PLNQTA 706
T LLL R A E G T L AA G+ ++L+++ ADV A TA
Sbjct: 1013 RTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTA 1072
Query: 707 LHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHIN 762
L +AA GH + E L+ ID+ +++G + L LAA G H V+ L++ GA ++
Sbjct: 1073 LTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVD 1129
Score = 118 bits (296), Expect = 2e-26
Identities = 102/303 (33%), Positives = 150/303 (49%), Gaps = 21/303 (6%)
Query: 495 ISVNAKDEDQW-TALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIV 553
I ++A+ E TAL A G E + LLE+ AS+ D +G TP+ +A G +V
Sbjct: 822 IDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVV 881
Query: 554 RILLRRGVDVSLQG---KDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHL 610
ILL G D+ Q KD PL A G +V+LL + G + + + TPL L
Sbjct: 882 EILLDNGADIEAQSERTKDT--PLSLACSGGRQEVVELLLAR-GANKEHRNVSDYTPLSL 938
Query: 611 AAQRGHYRVARILIDLCSDVN--VCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEA-MT 667
AA G+ + +IL++ +++N S L +PL +AA GHT+ +LLL G+ A +
Sbjct: 939 AASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIE 998
Query: 668 SDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELV--SA 725
++ TAL LA G V LL++ KA+V R T L AA+ G++EV L+ A
Sbjct: 999 TNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGA 1058
Query: 726 DV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQS--------LKFQGGHGPAA 776
DV +AL +AA H + E L+ GAHI++++ L GGH
Sbjct: 1059 DVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVV 1118
Query: 777 TLL 779
LL
Sbjct: 1119 QLL 1121
Score = 118 bits (295), Expect = 2e-26
Identities = 83/278 (29%), Positives = 138/278 (49%), Gaps = 17/278 (6%)
Query: 431 VDLALDSGASL-----------LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAV 479
V++ LD+GA + L LA G++E + LL AN N TPL +A
Sbjct: 881 VEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAA 940
Query: 480 ERRVRGVVELLLARKISVNAKDEDQW--TALHFAAQNGDESSTRLLLEKNASVN-EVDFE 536
++++LL +N++ + + L AA NG ++ +LLL+ + +N +++
Sbjct: 941 SGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETN 1000
Query: 537 GRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVS 596
T + +AC G+ +V +LL R +V + K PL AA G+ + ++L + G
Sbjct: 1001 RNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDK-GAD 1059
Query: 597 VNAQTLDGR--TPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTAR 654
VNA + T L +AA +GHY+ +LI + ++V + TPL +AA GH +
Sbjct: 1060 VNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQ 1119
Query: 655 LLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEE 692
LL+ GA +A + T L A R GH+ V+ LV+E
Sbjct: 1120 LLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE 1157
Score = 106 bits (264), Expect = 9e-23
Identities = 94/308 (30%), Positives = 137/308 (44%), Gaps = 7/308 (2%)
Query: 403 TDVQKKKLVDAIVSGDTSKLMKILQP-QDVDLALDSGASLLHLAVEAGQEECAKWLLLNN 461
TD L++A + G +L V++ DS S L LA G E A L+
Sbjct: 431 TDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERG 490
Query: 462 ANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDED-QWTALHFAAQNGDESST 520
A+ N G TPL A +V LLL + ++NA+ E+ Q TAL A G
Sbjct: 491 ASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVA 550
Query: 521 RLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQ 580
L++ A +++ TP+ A Q G +V+ LL G +V L YA
Sbjct: 551 DFLIKAGA---DIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACEN 607
Query: 581 GHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVN-VCSLLAQT 639
GH + +L Q G + ++ GRTPL AA+ GH + LI ++VN + T
Sbjct: 608 GHTDVADVLL-QAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHT 666
Query: 640 PLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLAR 699
L +A GH + LLL GA DG T L AA+ GH + V L++ ++L+
Sbjct: 667 VLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSA 726
Query: 700 GPLNQTAL 707
P + T L
Sbjct: 727 PPPDVTQL 734
Score = 67.8 bits (164), Expect = 4e-11
Identities = 58/176 (32%), Positives = 83/176 (47%), Gaps = 3/176 (1%)
Query: 596 SVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARL 655
+ NA D R+ L A G R L+ VN + ++ L +A G+ A++
Sbjct: 227 TANAGQSDNRS-LAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQV 285
Query: 656 LLHRGAGKEAMTSDG-YTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHG 714
LL A E G T L AA GH+ VKLL+ KADV A+ TAL A A G
Sbjct: 286 LLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGG 345
Query: 715 HSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSLKFQ 769
+ +VV+ L+ + I+ +E G + L A H + LL +GA IN S +F+
Sbjct: 346 YVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFK 401
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 166 bits (419), Expect = 1e-40
Identities = 116/354 (32%), Positives = 178/354 (50%), Gaps = 6/354 (1%)
Query: 410 LVDAIVSGDTSKLMKIL-QPQDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSN 468
LV AI S D ++ +L Q +++++ + LH A G + LL++ AN N +
Sbjct: 12 LVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKD 71
Query: 469 RRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNA 528
TPLH A R V+ LLLA VNA+D+ T LH AA N L +
Sbjct: 72 TLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLS 131
Query: 529 SVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKL 588
S+N D GR+ +H A G V +LL +G +++ K PLH+AA+ GHL ++KL
Sbjct: 132 SLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKL 191
Query: 589 LAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETG 648
L + G + + G LH AA G V + L+ + ++++ + T LH+A G
Sbjct: 192 LVAR-GADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLG 250
Query: 649 HTSTARLLLHRGAGKEAMTSDGYTALHLAA--RNGHLATVKLLVEEKADVLARGPLNQTA 706
+ A L++ GA G+T LH+AA NG L ++LLV ADV + ++
Sbjct: 251 QDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALC-LELLVNNGADVNYQSKEGKSP 309
Query: 707 LHLAAAHGHSEVVEELV-SADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGA 759
LH+AA HG + L+ + ID D+ G + LH+AA+ H + TL+ +GA
Sbjct: 310 LHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGA 363
Score = 146 bits (369), Expect = 6e-35
Identities = 116/401 (28%), Positives = 178/401 (44%), Gaps = 54/401 (13%)
Query: 397 TSDLGTTDVQKKKLVDAIVSGDTSKLMKILQP--QDVDLALDSGASLLHLAVEAGQEECA 454
++D+ D + + + +K + L P +++A SG S LH AV +G E
Sbjct: 97 SADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETV 156
Query: 455 KWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQN 514
LL A+ N+ +++ PLH A V++LL+AR + KD + LH AA +
Sbjct: 157 NLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAAS 216
Query: 515 GDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPL 574
G + LL A ++E + G T +H+AC GQ+ + L+ G +V+ + PL
Sbjct: 217 GQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPL 276
Query: 575 HYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCS 634
H AA + + L G VN Q+ +G++PLH+AA G + ++ILI S+++
Sbjct: 277 HVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCAD 336
Query: 635 LLAQTPLHVAAETGH-----------TSTARLLLH------------------------- 658
TPLHVAA GH TAR +H
Sbjct: 337 KFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQ 396
Query: 659 -------------RGAGKEAMTSD--GYTALHLAARNGHLATVKLLVEEKADVLARGPLN 703
AG + T D G T LH AA G++ + LL+ AD+ R
Sbjct: 397 LYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFG 456
Query: 704 QTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAA 743
+T LH AAA+G + LV+A ++ D +G S LH AA
Sbjct: 457 RTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAA 497
Score = 146 bits (368), Expect = 8e-35
Identities = 101/294 (34%), Positives = 147/294 (50%), Gaps = 3/294 (1%)
Query: 474 PLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEV 533
PL A+ R V LL++K ++N D+++ T LH AA GD +LLL A+VN
Sbjct: 11 PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAK 70
Query: 534 DFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQP 593
D TP+H A E ++ +LL DV+ + K PLH AA + LA
Sbjct: 71 DTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLL 130
Query: 594 GVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTA 653
S+N GR+ LH A GH +L++ + +NVC + PLH AA GH
Sbjct: 131 S-SLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVL 189
Query: 654 RLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAH 713
+LL+ RGA GY LH AA +G + VK L+ A++ TALH+A
Sbjct: 190 KLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYL 249
Query: 714 GHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRH-AQTVETLLRHGAHINLQS 765
G V ELV+A ++ +++G + LH+AA + A +E L+ +GA +N QS
Sbjct: 250 GQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQS 303
Score = 130 bits (327), Expect = 5e-30
Identities = 125/453 (27%), Positives = 191/453 (42%), Gaps = 55/453 (12%)
Query: 361 KLPSSGSGKRLSGVSSVDSAFSSRGSLSLSFEREPSTSDLGTTDVQKKKLVDAIVSGDTS 420
KL SSG + S+ S+ S+ LS F D+ T D + + A SG
Sbjct: 390 KLLSSGQ------LYSIVSSLSNEHVLSAGF-------DINTPDNLGRTCLHAAASGGNV 436
Query: 421 KLMKILQPQDVDLALDS--GASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMA 478
+ + +L DL G + LH A G +CA L+ A N ++ +G +PLH A
Sbjct: 437 ECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYA 496
Query: 479 V--------------------------ERRVRGV--VELLLARKISVNAKDEDQWTALHF 510
RR +E LL + +D +TA+H+
Sbjct: 497 AASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHY 556
Query: 511 AAQNGDESSTRLLLEKNASVNEVDFEGR---TPMHVACQHGQENIVRILLRRGVDVSLQG 567
AA G+ + LLLE + + E D E +P+H+A +G ++ L V++ ++
Sbjct: 557 AAAYGNRQNLELLLEMSFNCLE-DVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRD 615
Query: 568 KDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLC 627
L A +G V++L ++ + TPLH AA GH +LID
Sbjct: 616 HKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSG 675
Query: 628 SDVNVCSLL---AQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLA 684
++ ++ QTPL +A GH LLL +G+ +A G TALH A G
Sbjct: 676 ERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCED 735
Query: 685 TVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEEL----VSADVIDL-FDEQGLSAL 739
+ L++ A VL R +T +HLA+A GH+ V+ L +S D +D D G S +
Sbjct: 736 CLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPM 795
Query: 740 HLAAQGRHAQTVETLLRHGAHINLQSLKFQGGH 772
H A+ H +E LL H L+ F H
Sbjct: 796 HWASYTGHEDCLELLLEHSPFSYLEGNPFTPLH 828
Score = 129 bits (325), Expect = 8e-30
Identities = 129/453 (28%), Positives = 190/453 (41%), Gaps = 68/453 (15%)
Query: 379 SAFSSRGSLSLSFEREPSTSDLGTTDVQKKKLVDAIVSGDTSKLMKILQPQ-DVDLALDS 437
+A+ +R +L L E + + + + L A +G L + + ++D+
Sbjct: 558 AAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHK 617
Query: 438 GASLLHLAVEAGQEECAKWLLLNNANPNLSNRR--------------------------- 470
G + L LA E G EC + L + A+ + R+
Sbjct: 618 GRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGER 677
Query: 471 ----------GSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESST 520
G TPL +A+ V LLL + + +A D TALH A G E
Sbjct: 678 ADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCL 737
Query: 521 RLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRR---------GVDVSLQGKDAW 571
LL+ +A V DF+GRTP+H+A G ++R LL+ GVD S +
Sbjct: 738 AALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYS-----GY 792
Query: 572 LPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGR--TPLHLAAQRGHYRVARILIDLCSD 629
P+H+A++ GH ++LL + S L+G TPLH A +L+
Sbjct: 793 SPMHWASYTGHEDCLELLLEHSPFSY----LEGNPFTPLHCAVINNQDSTTEMLLGALGA 848
Query: 630 --VNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVK 687
VN +TPLH AA + S R+LL A A G TAL AA NG A V+
Sbjct: 849 KIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVE 908
Query: 688 -LLVEEKADVLARGPLNQTALHLAAAHGHSE----VVEELVSADVIDLFDEQGLSALHLA 742
LL KAD+ TALHLA + GH + ++ E +I+ + LH+A
Sbjct: 909 FLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIA 968
Query: 743 AQGRHAQTVETLLRHGAHINLQSLKFQGGHGPA 775
A+ A V+ LL HGA + + GH PA
Sbjct: 969 ARNGLASVVQALLSHGATVLAVD---EEGHTPA 998
Score = 120 bits (301), Expect = 5e-27
Identities = 99/358 (27%), Positives = 157/358 (43%), Gaps = 52/358 (14%)
Query: 453 CAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTA----L 508
C ++LL N A+P+L +R+G T +H A R +ELLL ++S N ++ + T L
Sbjct: 532 CLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLL--EMSFNCLEDVESTIPVSPL 589
Query: 509 HFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSL-QG 567
H AA NG + + L E +++ D +GRT + +A + G V +L G + +
Sbjct: 590 HLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKER 649
Query: 568 KDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLD--GRTPLHLAAQRGHYRVARILID 625
K W PLH AA GH + LL + +D G+TPL LA GH +L++
Sbjct: 650 KRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLE 709
Query: 626 LCSDVNVCSLLAQT---------------------------------PLHVAAETGHTST 652
S + L +T P+H+A+ GHT+
Sbjct: 710 KGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAV 769
Query: 653 ARLLLHRGAGKEAMTS----DGYTALHLAARNGHLATVKLLVEEKA-DVLARGPLNQTAL 707
R LL + + + GY+ +H A+ GH ++LL+E L P T L
Sbjct: 770 LRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPF--TPL 827
Query: 708 HLAAAHGHSEVVEELVSA---DVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHIN 762
H A + E L+ A +++ D +G + LH AA + + LL+H A +N
Sbjct: 828 HCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVN 885
Score = 93.6 bits (231), Expect = 6e-19
Identities = 87/290 (30%), Positives = 125/290 (43%), Gaps = 48/290 (16%)
Query: 413 AIVSGDTSKLMKILQP----QDVDLALD-SGASLLHLAVEAGQEECAKWLLLNNANPNLS 467
A G T+ L +LQ +D +D SG S +H A G E+C + LLL ++ +
Sbjct: 761 ASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLE-LLLEHSPFSYL 819
Query: 468 NRRGSTPLHMAVERRVRGVVELLLAR---KISVNAKDEDQWTALHFAAQNGDESSTRLLL 524
TPLH AV E+LL KI VN++D T LH AA + S R+LL
Sbjct: 820 EGNPFTPLHCAVINNQDSTTEMLLGALGAKI-VNSRDAKGRTPLHAAAFADNVSGLRMLL 878
Query: 525 EKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRG-VDVSLQGKDAWLPLHYAAWQGHL 583
+ A VN D GRT + A ++GQ V LL RG D+++ ++
Sbjct: 879 QHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENK------------- 925
Query: 584 PIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSD---VNVCSLLAQTP 640
T LHLA +GH + A +++ D +N + Q P
Sbjct: 926 ---------------------NTALHLACSKGHEKCALMILAETQDLGLINATNSALQMP 964
Query: 641 LHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLV 690
LH+AA G S + LL GA A+ +G+T A N +A L+
Sbjct: 965 LHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLALI 1014
Score = 50.4 bits (119), Expect = 6e-06
Identities = 47/168 (27%), Positives = 70/168 (41%), Gaps = 34/168 (20%)
Query: 630 VNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLL 689
+ + S+ Q PL A + R LL + + + T LH AA G + ++LL
Sbjct: 1 MGILSITDQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLL 60
Query: 690 VEEKADVLARGPLNQTALHLAAAHGHSEVVEELV--SADV-------------------- 727
+ A+V A+ L T LH AAA + +V+ L+ SADV
Sbjct: 61 LMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRAT 120
Query: 728 ------------IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINL 763
+++ D G SALH A H +TV LL GA +N+
Sbjct: 121 KCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNV 168
Score = 35.4 bits (80), Expect = 0.21
Identities = 23/85 (27%), Positives = 43/85 (50%), Gaps = 1/85 (1%)
Query: 686 VKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQ 744
V+ L+ +K ++ +T LH AA G +++ L+ + ++ D L+ LH AA
Sbjct: 24 VRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAA 83
Query: 745 GRHAQTVETLLRHGAHINLQSLKFQ 769
R+ + + LL H A +N + +Q
Sbjct: 84 SRNEKVLGLLLAHSADVNARDKLWQ 108
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 161 bits (407), Expect = 2e-39
Identities = 121/368 (32%), Positives = 170/368 (46%), Gaps = 35/368 (9%)
Query: 429 QDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVE 488
+DVD + L + G L+ A + ++ G TPL +A VV+
Sbjct: 706 EDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVD 765
Query: 489 LLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHG 548
LLL V+ D + T L AA G S LL A+V+ +D EGRT + +A G
Sbjct: 766 LLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQG 825
Query: 549 QENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPL 608
+VR LL RG+D + + W PLH AA++GH I + L +Q G N DGR P
Sbjct: 826 NVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQ-GARTNEIDNDGRIPF 884
Query: 609 HLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLL------------ 656
LA+Q GHY +IL++ S+++ + L VAA GH LL
Sbjct: 885 ILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDA 944
Query: 657 ---------------------LHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKAD 695
L GA EA ++G TALH++ GH+ V++L+ AD
Sbjct: 945 DGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHAD 1004
Query: 696 VLARGPLNQTALHLAAAHGHSEVVEELVS-ADVIDLFDEQGLSALHLAAQGRHAQTVETL 754
V A ++AL AA GH +VV+ L+ V+D QG +AL +AAQ H V+ L
Sbjct: 1005 VNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVL 1064
Query: 755 LRHGAHIN 762
L HGA N
Sbjct: 1065 LEHGADPN 1072
Score = 152 bits (383), Expect = 2e-36
Identities = 111/332 (33%), Positives = 160/332 (48%), Gaps = 7/332 (2%)
Query: 437 SGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKIS 496
+G +LL A +G + L+ A+ + + G TPL +A + VV L+ +
Sbjct: 544 NGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGAN 603
Query: 497 VNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRIL 556
+N D+D WTAL AA G LL V+ D + RT + A G E+IV L
Sbjct: 604 INHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNL 663
Query: 557 LRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLA----- 611
L+ G +V+ + L AA+ GH IV+ L G VN + +DGRT L +A
Sbjct: 664 LQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDH-GAEVNHEDVDGRTALSVAALCVP 722
Query: 612 AQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGY 671
A +GH V +LID ++V+ C TPL VAA GH LLL GA + ++G
Sbjct: 723 ASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGR 782
Query: 672 TALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADVIDLF 731
T L AA GH + V L+ A V + +T L +A+A G+ EVV L+ + +
Sbjct: 783 TPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENH 842
Query: 732 -DEQGLSALHLAAQGRHAQTVETLLRHGAHIN 762
D+ G + LH+AA H E L+ GA N
Sbjct: 843 RDDAGWTPLHMAAFEGHRLICEALIEQGARTN 874
Score = 149 bits (375), Expect = 1e-35
Identities = 108/332 (32%), Positives = 164/332 (49%), Gaps = 4/332 (1%)
Query: 430 DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVEL 489
DVD ++G + L A G LL A + + G T L +A + VV
Sbjct: 773 DVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRT 832
Query: 490 LLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQ 549
LL R + N +D+ WT LH AA G L+E+ A NE+D +GR P +A Q G
Sbjct: 833 LLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGH 892
Query: 550 ENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLH 609
+ V+ILL ++ +G D L AA +GH IV+LL G VN + DGR L+
Sbjct: 893 YDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSH-GADVNCKDADGRPTLY 951
Query: 610 LAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSD 669
+ A +A ++ ++V +T LHV+ GH ++L+ A A ++
Sbjct: 952 ILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNE 1011
Query: 670 GYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELV--SADV 727
+AL AA GH+ V+LL+E A V TAL +AA GH +VV+ L+ AD
Sbjct: 1012 KRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADP 1071
Query: 728 IDLFDEQGLSALHLAAQGRHAQTVETLLRHGA 759
+ D+ G +A+ +AA+ H+Q ++ L ++GA
Sbjct: 1072 -NHADQFGRTAMRVAAKNGHSQIIKLLEKYGA 1102
Score = 148 bits (373), Expect = 2e-35
Identities = 117/361 (32%), Positives = 170/361 (47%), Gaps = 10/361 (2%)
Query: 410 LVDAIVSGDTSKLMKILQPQDVDLALDS--GASLLHLAVEAGQEECAKWLLLNNANPNLS 467
L +A SG ++ +L + DL ++ G + L LA G + L+ AN N +
Sbjct: 549 LANAAYSGSLD-VVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHT 607
Query: 468 NRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKN 527
++ G T L A VV LL + V+ D D TAL AA G E LL+
Sbjct: 608 DQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHG 667
Query: 528 ASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAW-----QGH 582
A VN+ D EGRT + A G IV LL G +V+ + D L AA +GH
Sbjct: 668 AEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGH 727
Query: 583 LPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLH 642
+V LL + G V+ DG TPL +AA GH V +L++ +DV+ +TPL
Sbjct: 728 ASVVSLLIDR-GAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLL 786
Query: 643 VAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPL 702
AA GH S LL GA +++ S+G T L +A+ G++ V+ L++ D R
Sbjct: 787 AAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDA 846
Query: 703 NQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHI 761
T LH+AA GH + E L+ + D G LA+Q H V+ LL + ++I
Sbjct: 847 GWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNI 906
Query: 762 N 762
+
Sbjct: 907 D 907
Score = 141 bits (355), Expect = 3e-33
Identities = 112/333 (33%), Positives = 156/333 (46%), Gaps = 9/333 (2%)
Query: 436 DSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKI 495
D + ++ A+E +E+ + LL N A+ N + G T L A VV LL++R
Sbjct: 512 DRTSCIVRQALE--REDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGA 569
Query: 496 SVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRI 555
+ +D T L AA+ G L+ A++N D +G T + A G +V
Sbjct: 570 DLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSA 629
Query: 556 LLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRG 615
LL GV V D+ L AAW GH IV L Q G VN +GRT L AA G
Sbjct: 630 LLYAGVKVDCADADSRTALRAAAWGGHEDIV-LNLLQHGAEVNKADNEGRTALIAAAYMG 688
Query: 616 HYRVARILIDLCSDVNVCSLLAQTPLHVA-----AETGHTSTARLLLHRGAGKEAMTSDG 670
H + L+D ++VN + +T L VA A GH S LL+ RGA + DG
Sbjct: 689 HREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDG 748
Query: 671 YTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVS-ADVID 729
T L +AA GH+ V LL+E ADV +T L AA+ GH+ VV L+ +D
Sbjct: 749 MTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVD 808
Query: 730 LFDEQGLSALHLAAQGRHAQTVETLLRHGAHIN 762
D +G + L +A+ + + V TLL G N
Sbjct: 809 SIDSEGRTVLSIASAQGNVEVVRTLLDRGLDEN 841
Score = 123 bits (308), Expect = 8e-28
Identities = 101/331 (30%), Positives = 155/331 (46%), Gaps = 23/331 (6%)
Query: 441 LLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRV---RGVVELLLARKISV 497
L++ ++ E A W++ N TP+ ++ + + V++LL+ V
Sbjct: 459 LINSNLQLETAELALWMIWNG-----------TPVRDSLSTLIPKEQEVLQLLVKAGAHV 507
Query: 498 NAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILL 557
N++D+ + A + E S R LL+ ASVN+ D GRT + A G ++V +L+
Sbjct: 508 NSEDDRTSCIVRQALER--EDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLV 565
Query: 558 RRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHY 617
RG D+ ++ PL AA QGH +V L G ++N DG T L AA GH
Sbjct: 566 SRGADLEIEDAHGHTPLTLAARQGHTKVVNCLI-GCGANINHTDQDGWTALRSAAWGGHT 624
Query: 618 RVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLA 677
V L+ V+ ++T L AA GH LL GA ++G TAL A
Sbjct: 625 EVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAA 684
Query: 678 ARNGHLATVKLLVEEKA-----DVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLF 731
A GH V+ L++ A DV R L+ AL + A+ GH+ VV L+ +D
Sbjct: 685 AYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHC 744
Query: 732 DEQGLSALHLAAQGRHAQTVETLLRHGAHIN 762
D+ G++ L +AA H V+ LL GA ++
Sbjct: 745 DKDGMTPLLVAAYEGHVDVVDLLLEGGADVD 775
Score = 117 bits (294), Expect = 3e-26
Identities = 78/262 (29%), Positives = 122/262 (46%), Gaps = 1/262 (0%)
Query: 436 DSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKI 495
D+G + LH+A G + L+ A N + G P +A + V++LL K
Sbjct: 845 DAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKS 904
Query: 496 SVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRI 555
+++ + D AL AA G LL A VN D +GR +++ Q +
Sbjct: 905 NIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEY 964
Query: 556 LLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRG 615
L G +V + LH + WQGH+ +V++L VNA + R+ L AA +G
Sbjct: 965 FLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHA-DVNAADNEKRSALQSAAWQG 1023
Query: 616 HYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALH 675
H +V ++LI+ + V+ T L +AA+ GH ++LL GA G TA+
Sbjct: 1024 HVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMR 1083
Query: 676 LAARNGHLATVKLLVEEKADVL 697
+AA+NGH +KLL + A L
Sbjct: 1084 VAAKNGHSQIIKLLEKYGASSL 1105
Score = 90.5 bits (223), Expect = 5e-18
Identities = 65/191 (34%), Positives = 90/191 (47%), Gaps = 1/191 (0%)
Query: 594 GVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTA 653
G SVN +GRT L AA G V +L+ +D+ + TPL +AA GHT
Sbjct: 535 GASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVV 594
Query: 654 RLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAH 713
L+ GA DG+TAL AA GH V L+ V ++TAL AA
Sbjct: 595 NCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWG 654
Query: 714 GHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSLKFQGGH 772
GH ++V L+ ++ D +G +AL AA H + VE LL HGA +N + + +
Sbjct: 655 GHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTAL 714
Query: 773 GPAATLLRRSK 783
AA + SK
Sbjct: 715 SVAALCVPASK 725
Score = 82.8 bits (203), Expect = 1e-15
Identities = 56/185 (30%), Positives = 91/185 (49%), Gaps = 3/185 (1%)
Query: 430 DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVEL 489
DV+ G L++ Q A++ L N AN S+ G T LH++ + +V++
Sbjct: 938 DVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQV 997
Query: 490 LLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQ 549
L+A VNA D ++ +AL AA G +LL+E A V+ +G T + +A Q G
Sbjct: 998 LIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGH 1057
Query: 550 ENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLH 609
++V++LL G D + + + AA GH I+KLL K S+N + +P+H
Sbjct: 1058 IDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNGCS---PSPVH 1114
Query: 610 LAAQR 614
Q+
Sbjct: 1115 TMEQK 1119
>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
[Homo sapiens]
Length = 616
Score = 159 bits (403), Expect = 7e-39
Identities = 136/434 (31%), Positives = 213/434 (49%), Gaps = 15/434 (3%)
Query: 336 LSQLDSGVSQAVEGPEELSRSSSESKLPSSGSGKRLSGVSSVDSAFSSRGSLSLSFEREP 395
LS G PE +R + + + + L ++S S + +L+ +
Sbjct: 126 LSSTAEGADLRTVDPETQARLEALLEAAAFADPEVLRRLTSSVSCALDEAAAALTRMKAE 185
Query: 396 STSDLGTTDVQKKKLVDAIVSGDTSKLMKIL-QPQDVDLALDSGASLLHLAVEAGQEECA 454
++ + G D + L +A GD + + K+L + + V+ + G SLL LA AG E A
Sbjct: 186 NSHNAGQVDT--RSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELA 243
Query: 455 KWLLLNNANPNLSNRRGS-TPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQ 513
+ LL +AN +G TPL A +V+LLL VN++ TAL +A
Sbjct: 244 QVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACA 303
Query: 514 NGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQG---KDA 570
G ++LL + A++ + + G TP+ A G + R+LL G ++ K++
Sbjct: 304 GGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKES 363
Query: 571 WLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDV 630
L L A ++GHL +V+ L + G +T + T L A GH VAR+L+D + V
Sbjct: 364 ALTL--ACYKGHLDMVRFLL-EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQV 420
Query: 631 NVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLV 690
N+ + ++PL +AA GH A LL+ RGA E + +GYT L AAR GH V LL+
Sbjct: 421 NMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLL 480
Query: 691 EEKADVLARGPLNQ-TALHLAAAHGHSEVVEELVSADVIDLFDEQGLSA-LHLAAQGRHA 748
+ A++ A+ Q TAL LA G SEV + L+ A D+ E G S L A+Q H
Sbjct: 481 AQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA-DI--ELGCSTPLMEASQEGHL 537
Query: 749 QTVETLLRHGAHIN 762
+ V+ LL GA+++
Sbjct: 538 ELVKYLLASGANVH 551
Score = 110 bits (275), Expect = 5e-24
Identities = 88/263 (33%), Positives = 132/263 (50%), Gaps = 6/263 (2%)
Query: 511 AAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQG-KD 569
A +GD ++ R LL++ SVNE EG + + +AC G + ++LL +V +G K
Sbjct: 201 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 260
Query: 570 AWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSD 629
PL A+ G+L IVKLL VN+Q+ G T L A G + ++L++ ++
Sbjct: 261 DITPLMAASSGGYLDIVKLLLLHDA-DVNSQSATGNTALTYACAGGFVDIVKVLLNEGAN 319
Query: 630 VNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSD-GYTALHLAARNGHLATVKL 688
+ + TPL AA GH AR+LL GAG +++ +AL LA GHL V+
Sbjct: 320 IEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRF 379
Query: 689 LVEEKADVLARGPLNQTALHLAAAHGHSEVVEELV-SADVIDLFDEQGLSALHLAAQGRH 747
L+E AD + TAL A GH EV L+ S +++ + S L LAA G H
Sbjct: 380 LLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGH 439
Query: 748 AQTVETLLRHGAHINLQSLKFQG 770
+ L+ GA NL+ + +G
Sbjct: 440 VELAALLIERGA--NLEEVNDEG 460
Score = 106 bits (264), Expect = 9e-23
Identities = 87/264 (32%), Positives = 127/264 (48%), Gaps = 8/264 (3%)
Query: 436 DSGASLLHLAVEAGQEECAKWLLLNNANPNL-SNRRGSTPLHMAVERRVRGVVELLLARK 494
++G + L A AG E A+ LL + A N SN + L +A + +V LL
Sbjct: 325 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAG 384
Query: 495 ISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVR 554
K ++ TAL A +G RLLL+ A VN +P+ +A G +
Sbjct: 385 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAA 444
Query: 555 ILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGR-TPLHLAAQ 613
+L+ RG ++ + + PL AA +GH +V LL Q G ++NAQT + + T L LA
Sbjct: 445 LLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ-GANINAQTEETQETALTLACC 503
Query: 614 RGHYRVARILIDLCSDVNV-CSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYT 672
G VA LI +D+ + CS TPL A++ GH + LL GA A T+ G T
Sbjct: 504 GGFSEVADFLIKAGADIELGCS----TPLMEASQEGHLELVKYLLASGANVHATTATGDT 559
Query: 673 ALHLAARNGHLATVKLLVEEKADV 696
AL A NGH +L++ AD+
Sbjct: 560 ALTYACENGHTDVADVLLQAGADL 583
Score = 57.0 bits (136), Expect = 7e-08
Identities = 54/196 (27%), Positives = 79/196 (40%), Gaps = 32/196 (16%)
Query: 403 TDVQKKKLVDAIVSGDTSKLMKILQP-QDVDLALDSGASLLHLAVEAGQEECAKWLLLNN 461
TD L++A + G +L V++ DS S L LA G E A L+
Sbjct: 391 TDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERG 450
Query: 462 ANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDED-QWTALHFA--------- 511
AN N G TPL A +V LLLA+ ++NA+ E+ Q TAL A
Sbjct: 451 ANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVA 510
Query: 512 ---------------------AQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQE 550
+Q G + LL A+V+ G T + AC++G
Sbjct: 511 DFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHT 570
Query: 551 NIVRILLRRGVDVSLQ 566
++ +LL+ G D+ Q
Sbjct: 571 DVADVLLQAGADLDKQ 586
Score = 32.7 bits (73), Expect = 1.3
Identities = 31/107 (28%), Positives = 46/107 (42%), Gaps = 3/107 (2%)
Query: 402 TTDVQKKKLVDAIVSGDTSKLMKILQPQDVDLALDSGASLLHLAVEAGQEECAKWLLLNN 461
T + Q+ L A G S++ L D+ L L+ + E G E K+LL +
Sbjct: 490 TEETQETALTLACCGG-FSEVADFLIKAGADIELGCSTPLMEASQE-GHLELVKYLLASG 547
Query: 462 ANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTAL 508
AN + + G T L A E V ++LL ++ K ED T L
Sbjct: 548 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLD-KQEDMKTIL 593
>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
[Homo sapiens]
Length = 627
Score = 158 bits (400), Expect = 2e-38
Identities = 142/445 (31%), Positives = 215/445 (48%), Gaps = 26/445 (5%)
Query: 336 LSQLDSGVSQAVEGPEELSRSSSESKLPSSGSGK--RLSGVSSVDSAFSSRGSLSLSFER 393
LS G PE +R E+ L ++G GK G + D R + S+S
Sbjct: 126 LSSTAEGADLRTVDPETQARL--EALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCAL 183
Query: 394 EPSTSDL---------GTTDVQKKKLVDAIVSGDTSKLMKIL-QPQDVDLALDSGASLLH 443
+ + + L V + L +A GD + + K+L + + V+ + G SLL
Sbjct: 184 DEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLC 243
Query: 444 LAVEAGQEECAKWLLLNNANPNLSNRRGS-TPLHMAVERRVRGVVELLLARKISVNAKDE 502
LA AG E A+ LL +AN +G TPL A +V+LLL VN++
Sbjct: 244 LACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSA 303
Query: 503 DQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVD 562
TAL +A G ++LL + A++ + + G TP+ A G + R+LL G
Sbjct: 304 TGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAG 363
Query: 563 VSLQG---KDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRV 619
++ K++ L L A ++GHL +V+ L + G +T + T L A GH V
Sbjct: 364 INTHSNEFKESALTL--ACYKGHLDMVRFLL-EAGADQEHKTDEMHTALMEACMDGHVEV 420
Query: 620 ARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAAR 679
AR+L+D + VN+ + ++PL +AA GH A LL+ RGA E + +GYT L AAR
Sbjct: 421 ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR 480
Query: 680 NGHLATVKLLVEEKADVLARGPLNQ-TALHLAAAHGHSEVVEELVSADVIDLFDEQGLSA 738
GH V LL+ + A++ A+ Q TAL LA G SEV + L+ A D+ E G S
Sbjct: 481 EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA-DI--ELGCST 537
Query: 739 -LHLAAQGRHAQTVETLLRHGAHIN 762
L A+Q H + V+ LL GA+++
Sbjct: 538 PLMEASQEGHLELVKYLLASGANVH 562
Score = 110 bits (276), Expect = 4e-24
Identities = 125/442 (28%), Positives = 188/442 (42%), Gaps = 19/442 (4%)
Query: 342 GVSQAVEGPEELSRSSSESKLPSSGSGKRLSGVSSVDSAFSSRGSLSLSFEREPSTSDLG 401
GV + + S + SSG G SG D+A + L+ + R
Sbjct: 36 GVGLGIRTVRLFGEAGPASGVGSSGGGGSGSGTGGGDAALDFK--LAAAVLRTGGGGGAS 93
Query: 402 TTDVQKKKLVDAIVSGDTSKLMKILQPQDVDLALDSGASLLHLAVEAGQEECAKWLLLNN 461
+D + V++ + D L + ++ L S A L + + LL
Sbjct: 94 GSDEDEVSEVESFIL-DQEDLDNPVLKTTSEIFLSSTAEGADLRTVDPETQARLEALLEA 152
Query: 462 AN-PNLSNRRGSTPLHMAVERRVRGVVELLL--ARKISVNAKDEDQWTA-------LHFA 511
A LS G V RR+ V L A K E+ A L A
Sbjct: 153 AGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEA 212
Query: 512 AQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQG-KDA 570
+GD ++ R LL++ SVNE EG + + +AC G + ++LL +V +G K
Sbjct: 213 CSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGD 272
Query: 571 WLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDV 630
PL A+ G+L IVKLL VN+Q+ G T L A G + ++L++ +++
Sbjct: 273 ITPLMAASSGGYLDIVKLLLLHDA-DVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 331
Query: 631 NVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSD-GYTALHLAARNGHLATVKLL 689
+ TPL AA GH AR+LL GAG +++ +AL LA GHL V+ L
Sbjct: 332 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFL 391
Query: 690 VEEKADVLARGPLNQTALHLAAAHGHSEVVEELV-SADVIDLFDEQGLSALHLAAQGRHA 748
+E AD + TAL A GH EV L+ S +++ + S L LAA G H
Sbjct: 392 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 451
Query: 749 QTVETLLRHGAHINLQSLKFQG 770
+ L+ GA NL+ + +G
Sbjct: 452 ELAALLIERGA--NLEEVNDEG 471
Score = 106 bits (264), Expect = 9e-23
Identities = 87/264 (32%), Positives = 127/264 (48%), Gaps = 8/264 (3%)
Query: 436 DSGASLLHLAVEAGQEECAKWLLLNNANPNL-SNRRGSTPLHMAVERRVRGVVELLLARK 494
++G + L A AG E A+ LL + A N SN + L +A + +V LL
Sbjct: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAG 395
Query: 495 ISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVR 554
K ++ TAL A +G RLLL+ A VN +P+ +A G +
Sbjct: 396 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAA 455
Query: 555 ILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGR-TPLHLAAQ 613
+L+ RG ++ + + PL AA +GH +V LL Q G ++NAQT + + T L LA
Sbjct: 456 LLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ-GANINAQTEETQETALTLACC 514
Query: 614 RGHYRVARILIDLCSDVNV-CSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYT 672
G VA LI +D+ + CS TPL A++ GH + LL GA A T+ G T
Sbjct: 515 GGFSEVADFLIKAGADIELGCS----TPLMEASQEGHLELVKYLLASGANVHATTATGDT 570
Query: 673 ALHLAARNGHLATVKLLVEEKADV 696
AL A NGH +L++ AD+
Sbjct: 571 ALTYACENGHTDVADVLLQAGADL 594
Score = 57.0 bits (136), Expect = 7e-08
Identities = 54/196 (27%), Positives = 79/196 (40%), Gaps = 32/196 (16%)
Query: 403 TDVQKKKLVDAIVSGDTSKLMKILQP-QDVDLALDSGASLLHLAVEAGQEECAKWLLLNN 461
TD L++A + G +L V++ DS S L LA G E A L+
Sbjct: 402 TDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERG 461
Query: 462 ANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDED-QWTALHFA--------- 511
AN N G TPL A +V LLLA+ ++NA+ E+ Q TAL A
Sbjct: 462 ANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVA 521
Query: 512 ---------------------AQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQE 550
+Q G + LL A+V+ G T + AC++G
Sbjct: 522 DFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHT 581
Query: 551 NIVRILLRRGVDVSLQ 566
++ +LL+ G D+ Q
Sbjct: 582 DVADVLLQAGADLDKQ 597
Score = 32.7 bits (73), Expect = 1.3
Identities = 31/107 (28%), Positives = 46/107 (42%), Gaps = 3/107 (2%)
Query: 402 TTDVQKKKLVDAIVSGDTSKLMKILQPQDVDLALDSGASLLHLAVEAGQEECAKWLLLNN 461
T + Q+ L A G S++ L D+ L L+ + E G E K+LL +
Sbjct: 501 TEETQETALTLACCGG-FSEVADFLIKAGADIELGCSTPLMEASQE-GHLELVKYLLASG 558
Query: 462 ANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTAL 508
AN + + G T L A E V ++LL ++ K ED T L
Sbjct: 559 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLD-KQEDMKTIL 604
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
[Homo sapiens]
Length = 2542
Score = 158 bits (400), Expect = 2e-38
Identities = 142/445 (31%), Positives = 215/445 (48%), Gaps = 26/445 (5%)
Query: 336 LSQLDSGVSQAVEGPEELSRSSSESKLPSSGSGK--RLSGVSSVDSAFSSRGSLSLSFER 393
LS G PE +R E+ L ++G GK G + D R + S+S
Sbjct: 126 LSSTAEGADLRTVDPETQARL--EALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCAL 183
Query: 394 EPSTSDL---------GTTDVQKKKLVDAIVSGDTSKLMKIL-QPQDVDLALDSGASLLH 443
+ + + L V + L +A GD + + K+L + + V+ + G SLL
Sbjct: 184 DEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLC 243
Query: 444 LAVEAGQEECAKWLLLNNANPNLSNRRGS-TPLHMAVERRVRGVVELLLARKISVNAKDE 502
LA AG E A+ LL +AN +G TPL A +V+LLL VN++
Sbjct: 244 LACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSA 303
Query: 503 DQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVD 562
TAL +A G ++LL + A++ + + G TP+ A G + R+LL G
Sbjct: 304 TGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAG 363
Query: 563 VSLQG---KDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRV 619
++ K++ L L A ++GHL +V+ L + G +T + T L A GH V
Sbjct: 364 INTHSNEFKESALTL--ACYKGHLDMVRFLL-EAGADQEHKTDEMHTALMEACMDGHVEV 420
Query: 620 ARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAAR 679
AR+L+D + VN+ + ++PL +AA GH A LL+ RGA E + +GYT L AAR
Sbjct: 421 ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR 480
Query: 680 NGHLATVKLLVEEKADVLARGPLNQ-TALHLAAAHGHSEVVEELVSADVIDLFDEQGLSA 738
GH V LL+ + A++ A+ Q TAL LA G SEV + L+ A D+ E G S
Sbjct: 481 EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA-DI--ELGCST 537
Query: 739 -LHLAAQGRHAQTVETLLRHGAHIN 762
L A+Q H + V+ LL GA+++
Sbjct: 538 PLMEASQEGHLELVKYLLASGANVH 562
Score = 139 bits (349), Expect = 1e-32
Identities = 118/370 (31%), Positives = 176/370 (47%), Gaps = 10/370 (2%)
Query: 396 STSDLGTTDVQKKKLVDAIVSGDTSKLMKILQPQ-DVDLALDSGA-SLLHLAVEAGQEEC 453
S S TT+ + S S+ M + P D+D +S + L LA G EE
Sbjct: 1011 SNSSSQTTECLTPESCSQTTSNVASQSMPPVYPSVDIDAHTESNHDTALTLACAGGHEEL 1070
Query: 454 AKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDE-DQWTALHFAA 512
L+ +A +++G TPL +A GVVE+LL + + A+ E + T L A
Sbjct: 1071 VSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLAC 1130
Query: 513 QNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQ--GKDA 570
G + LLL + A+ + TP+ +A G NI++ILL G +++ + K
Sbjct: 1131 SGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLG 1190
Query: 571 WLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGR-TPLHLAAQRGHYRVARILIDLCSD 629
PL AA GH+P VKLL G +NAQ R T L LA +G V +L+D ++
Sbjct: 1191 ISPLMLAAMNGHVPAVKLLLDM-GSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKAN 1249
Query: 630 VNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEA--MTSDGYTALHLAARNGHLATVK 687
V + TPL AA G+ R+LL +GA A + S TAL +AA GH +
Sbjct: 1250 VEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCE 1309
Query: 688 LLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGR 746
LL+ A + R T L LA+ GH +VV+ LV A +D D + ++ L A +
Sbjct: 1310 LLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKG 1369
Query: 747 HAQTVETLLR 756
H + V+ L++
Sbjct: 1370 HVKVVQYLVK 1379
Score = 127 bits (319), Expect = 4e-29
Identities = 109/329 (33%), Positives = 155/329 (47%), Gaps = 10/329 (3%)
Query: 436 DSGASLLHLAVEAGQEECAKWLLLNNANPNL-SNRRGSTPLHMAVERRVRGVVELLLARK 494
++G + L A AG E A+ LL + A N SN + L +A + +V LL
Sbjct: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAG 395
Query: 495 ISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVR 554
K ++ TAL A +G RLLL+ A VN +P+ +A G +
Sbjct: 396 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAA 455
Query: 555 ILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGR-TPLHLAAQ 613
+L+ RG ++ + + PL AA +GH +V LL Q G ++NAQT + + T L LA
Sbjct: 456 LLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ-GANINAQTEETQETALTLACC 514
Query: 614 RGHYRVARILIDLCSDVNV-CSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYT 672
G VA LI +D+ + CS TPL A++ GH + LL GA A T+ G T
Sbjct: 515 GGFSEVADFLIKAGADIELGCS----TPLMEASQEGHLELVKYLLASGANVHATTATGDT 570
Query: 673 ALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVS--ADVIDL 730
AL A NGH +L++ AD+ +T L AA GH V+ L+S A+V
Sbjct: 571 ALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRA 630
Query: 731 FDEQGLSALHLAAQGRHAQTVETLLRHGA 759
+ + LA G H VE LL HGA
Sbjct: 631 TANNDHTVVSLACAGGHLAVVELLLAHGA 659
Score = 122 bits (305), Expect = 2e-27
Identities = 92/297 (30%), Positives = 147/297 (49%), Gaps = 8/297 (2%)
Query: 473 TPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNE 532
T L +A +V +L+AR + +D+ +T L AA G +LL+K +
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116
Query: 533 VDFEGR-TPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAK 591
+ TP+ +AC G++ +V +LL RG + + + PL AA G++ I+K+L
Sbjct: 1117 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1176
Query: 592 QPGVSVNAQTLD--GRTPLHLAAQRGHYRVARILIDLCSDVNV-CSLLAQTPLHVAAETG 648
G +N++T G +PL LAA GH ++L+D+ SD+N T L +A G
Sbjct: 1177 A-GAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQG 1235
Query: 649 HTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARG--PLNQTA 706
LLL R A E G T L AA G+ ++L+++ ADV A TA
Sbjct: 1236 RAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTA 1295
Query: 707 LHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHIN 762
L +AA GH + E L+ ID+ +++G + L LA+ G H V+ L++ GA ++
Sbjct: 1296 LTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVD 1352
Score = 112 bits (279), Expect = 2e-24
Identities = 81/278 (29%), Positives = 134/278 (48%), Gaps = 17/278 (6%)
Query: 431 VDLALDSGASL-----------LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAV 479
V++ LD G + L LA G++E LL AN N TPL +A
Sbjct: 1104 VEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAA 1163
Query: 480 ERRVRGVVELLLARKISVNAKDEDQW--TALHFAAQNGDESSTRLLLEKNASVN-EVDFE 536
++++LL +N++ + + L AA NG + +LLL+ + +N +++
Sbjct: 1164 SGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETN 1223
Query: 537 GRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVS 596
T + +AC G+ +V +LL R +V + K PL AA G+ + ++L + G
Sbjct: 1224 RNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDK-GAD 1282
Query: 597 VNAQTLDGR--TPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTAR 654
VNA + T L +AA +GHY+ +LI + ++V + TPL +A+ GH +
Sbjct: 1283 VNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQ 1342
Query: 655 LLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEE 692
LL+ GA +A + T L A R GH+ V+ LV+E
Sbjct: 1343 LLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
Score = 110 bits (276), Expect = 4e-24
Identities = 125/442 (28%), Positives = 188/442 (42%), Gaps = 19/442 (4%)
Query: 342 GVSQAVEGPEELSRSSSESKLPSSGSGKRLSGVSSVDSAFSSRGSLSLSFEREPSTSDLG 401
GV + + S + SSG G SG D+A + L+ + R
Sbjct: 36 GVGLGIRTVRLFGEAGPASGVGSSGGGGSGSGTGGGDAALDFK--LAAAVLRTGGGGGAS 93
Query: 402 TTDVQKKKLVDAIVSGDTSKLMKILQPQDVDLALDSGASLLHLAVEAGQEECAKWLLLNN 461
+D + V++ + D L + ++ L S A L + + LL
Sbjct: 94 GSDEDEVSEVESFIL-DQEDLDNPVLKTTSEIFLSSTAEGADLRTVDPETQARLEALLEA 152
Query: 462 AN-PNLSNRRGSTPLHMAVERRVRGVVELLL--ARKISVNAKDEDQWTA-------LHFA 511
A LS G V RR+ V L A K E+ A L A
Sbjct: 153 AGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEA 212
Query: 512 AQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQG-KDA 570
+GD ++ R LL++ SVNE EG + + +AC G + ++LL +V +G K
Sbjct: 213 CSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGD 272
Query: 571 WLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDV 630
PL A+ G+L IVKLL VN+Q+ G T L A G + ++L++ +++
Sbjct: 273 ITPLMAASSGGYLDIVKLLLLHDA-DVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 331
Query: 631 NVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSD-GYTALHLAARNGHLATVKLL 689
+ TPL AA GH AR+LL GAG +++ +AL LA GHL V+ L
Sbjct: 332 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFL 391
Query: 690 VEEKADVLARGPLNQTALHLAAAHGHSEVVEELV-SADVIDLFDEQGLSALHLAAQGRHA 748
+E AD + TAL A GH EV L+ S +++ + S L LAA G H
Sbjct: 392 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 451
Query: 749 QTVETLLRHGAHINLQSLKFQG 770
+ L+ GA NL+ + +G
Sbjct: 452 ELAALLIERGA--NLEEVNDEG 471
Score = 107 bits (267), Expect = 4e-23
Identities = 93/299 (31%), Positives = 133/299 (44%), Gaps = 7/299 (2%)
Query: 403 TDVQKKKLVDAIVSGDTSKLMKILQP-QDVDLALDSGASLLHLAVEAGQEECAKWLLLNN 461
TD L++A + G +L V++ DS S L LA G E A L+
Sbjct: 402 TDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERG 461
Query: 462 ANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDED-QWTALHFAAQNGDESST 520
AN N G TPL A +V LLLA+ ++NA+ E+ Q TAL A G
Sbjct: 462 ANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVA 521
Query: 521 RLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQ 580
L++ A +++ TP+ A Q G +V+ LL G +V L YA
Sbjct: 522 DFLIKAGA---DIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACEN 578
Query: 581 GHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQ-T 639
GH + +L Q G + ++ GRTPL AA+ GH + LI ++VN + T
Sbjct: 579 GHTDVADVLL-QAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHT 637
Query: 640 PLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLA 698
+ +A GH + LLL GA DG T L AA+ GH V L++ +VL+
Sbjct: 638 VVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLS 696
Score = 69.3 bits (168), Expect = 1e-11
Identities = 57/185 (30%), Positives = 78/185 (42%), Gaps = 32/185 (17%)
Query: 581 GHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQ-T 639
GH +V +L + + + G TPL LAA GH V IL+D D+ S + T
Sbjct: 1066 GHEELVSVLIARDA-KIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDT 1124
Query: 640 PLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLAR 699
PL +A G LLL RGA KE YT L LAA G++ +K+L+ A++ +R
Sbjct: 1125 PLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSR 1184
Query: 700 GPLNQTALHLAAAHGHSEVVEELVSADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGA 759
+ G+S L LAA H V+ LL G+
Sbjct: 1185 TG------------------------------SKLGISPLMLAAMNGHVPAVKLLLDMGS 1214
Query: 760 HINLQ 764
IN Q
Sbjct: 1215 DINAQ 1219
Score = 65.9 bits (159), Expect = 1e-10
Identities = 58/203 (28%), Positives = 87/203 (42%), Gaps = 3/203 (1%)
Query: 402 TTDVQKKKLVDAIVSGDTSKLMKILQPQDVDLALDSGASLLHLAVEAGQEECAKWLLLNN 461
T + Q+ L A G S++ L D+ L L+ + E G E K+LL +
Sbjct: 501 TEETQETALTLACCGG-FSEVADFLIKAGADIELGCSTPLMEASQE-GHLELVKYLLASG 558
Query: 462 ANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTR 521
AN + + G T L A E V ++LL + + E T L AA+ G + +
Sbjct: 559 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQ 618
Query: 522 LLLEKNASVNEVDFEG-RTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQ 580
L+ K A+VN T + +AC G +V +LL G D + + KD L AA
Sbjct: 619 FLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKG 678
Query: 581 GHLPIVKLLAKQPGVSVNAQTLD 603
GH +V L P ++ T D
Sbjct: 679 GHTNVVSYLLDYPNNVLSVPTTD 701
Score = 61.2 bits (147), Expect = 4e-09
Identities = 48/153 (31%), Positives = 72/153 (47%), Gaps = 12/153 (7%)
Query: 639 TPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLA 698
T L +A GH +L+ R A E G+T L LAA GH+ V++L+++ D+ A
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116
Query: 699 RGP-LNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLR 756
+ T L LA + G EVV+ L++ + + + L LAA G + ++ LL
Sbjct: 1117 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1176
Query: 757 HGAHINLQS----------LKFQGGHGPAATLL 779
GA IN ++ L GH PA LL
Sbjct: 1177 AGAEINSRTGSKLGISPLMLAAMNGHVPAVKLL 1209
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 158 bits (400), Expect = 2e-38
Identities = 142/445 (31%), Positives = 215/445 (48%), Gaps = 26/445 (5%)
Query: 336 LSQLDSGVSQAVEGPEELSRSSSESKLPSSGSGK--RLSGVSSVDSAFSSRGSLSLSFER 393
LS G PE +R E+ L ++G GK G + D R + S+S
Sbjct: 126 LSSTAEGADLRTVDPETQARL--EALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCAL 183
Query: 394 EPSTSDL---------GTTDVQKKKLVDAIVSGDTSKLMKIL-QPQDVDLALDSGASLLH 443
+ + + L V + L +A GD + + K+L + + V+ + G SLL
Sbjct: 184 DEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLC 243
Query: 444 LAVEAGQEECAKWLLLNNANPNLSNRRGS-TPLHMAVERRVRGVVELLLARKISVNAKDE 502
LA AG E A+ LL +AN +G TPL A +V+LLL VN++
Sbjct: 244 LACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSA 303
Query: 503 DQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVD 562
TAL +A G ++LL + A++ + + G TP+ A G + R+LL G
Sbjct: 304 TGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAG 363
Query: 563 VSLQG---KDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRV 619
++ K++ L L A ++GHL +V+ L + G +T + T L A GH V
Sbjct: 364 INTHSNEFKESALTL--ACYKGHLDMVRFLL-EAGADQEHKTDEMHTALMEACMDGHVEV 420
Query: 620 ARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAAR 679
AR+L+D + VN+ + ++PL +AA GH A LL+ RGA E + +GYT L AAR
Sbjct: 421 ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR 480
Query: 680 NGHLATVKLLVEEKADVLARGPLNQ-TALHLAAAHGHSEVVEELVSADVIDLFDEQGLSA 738
GH V LL+ + A++ A+ Q TAL LA G SEV + L+ A D+ E G S
Sbjct: 481 EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA-DI--ELGCST 537
Query: 739 -LHLAAQGRHAQTVETLLRHGAHIN 762
L A+Q H + V+ LL GA+++
Sbjct: 538 PLMEASQEGHLELVKYLLASGANVH 562
Score = 139 bits (349), Expect = 1e-32
Identities = 118/370 (31%), Positives = 176/370 (47%), Gaps = 10/370 (2%)
Query: 396 STSDLGTTDVQKKKLVDAIVSGDTSKLMKILQPQ-DVDLALDSGA-SLLHLAVEAGQEEC 453
S S TT+ + S S+ M + P D+D +S + L LA G EE
Sbjct: 1011 SNSSSQTTECLTPESCSQTTSNVASQSMPPVYPSVDIDAHTESNHDTALTLACAGGHEEL 1070
Query: 454 AKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDE-DQWTALHFAA 512
L+ +A +++G TPL +A GVVE+LL + + A+ E + T L A
Sbjct: 1071 VSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLAC 1130
Query: 513 QNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQ--GKDA 570
G + LLL + A+ + TP+ +A G NI++ILL G +++ + K
Sbjct: 1131 SGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLG 1190
Query: 571 WLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGR-TPLHLAAQRGHYRVARILIDLCSD 629
PL AA GH+P VKLL G +NAQ R T L LA +G V +L+D ++
Sbjct: 1191 ISPLMLAAMNGHVPAVKLLLDM-GSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKAN 1249
Query: 630 VNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEA--MTSDGYTALHLAARNGHLATVK 687
V + TPL AA G+ R+LL +GA A + S TAL +AA GH +
Sbjct: 1250 VEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCE 1309
Query: 688 LLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGR 746
LL+ A + R T L LA+ GH +VV+ LV A +D D + ++ L A +
Sbjct: 1310 LLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKG 1369
Query: 747 HAQTVETLLR 756
H + V+ L++
Sbjct: 1370 HVKVVQYLVK 1379
Score = 127 bits (319), Expect = 4e-29
Identities = 109/329 (33%), Positives = 155/329 (47%), Gaps = 10/329 (3%)
Query: 436 DSGASLLHLAVEAGQEECAKWLLLNNANPNL-SNRRGSTPLHMAVERRVRGVVELLLARK 494
++G + L A AG E A+ LL + A N SN + L +A + +V LL
Sbjct: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAG 395
Query: 495 ISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVR 554
K ++ TAL A +G RLLL+ A VN +P+ +A G +
Sbjct: 396 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAA 455
Query: 555 ILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGR-TPLHLAAQ 613
+L+ RG ++ + + PL AA +GH +V LL Q G ++NAQT + + T L LA
Sbjct: 456 LLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ-GANINAQTEETQETALTLACC 514
Query: 614 RGHYRVARILIDLCSDVNV-CSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYT 672
G VA LI +D+ + CS TPL A++ GH + LL GA A T+ G T
Sbjct: 515 GGFSEVADFLIKAGADIELGCS----TPLMEASQEGHLELVKYLLASGANVHATTATGDT 570
Query: 673 ALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVS--ADVIDL 730
AL A NGH +L++ AD+ +T L AA GH V+ L+S A+V
Sbjct: 571 ALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRA 630
Query: 731 FDEQGLSALHLAAQGRHAQTVETLLRHGA 759
+ + LA G H VE LL HGA
Sbjct: 631 TANNDHTVVSLACAGGHLAVVELLLAHGA 659
Score = 122 bits (305), Expect = 2e-27
Identities = 92/297 (30%), Positives = 147/297 (49%), Gaps = 8/297 (2%)
Query: 473 TPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNE 532
T L +A +V +L+AR + +D+ +T L AA G +LL+K +
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116
Query: 533 VDFEGR-TPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAK 591
+ TP+ +AC G++ +V +LL RG + + + PL AA G++ I+K+L
Sbjct: 1117 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1176
Query: 592 QPGVSVNAQTLD--GRTPLHLAAQRGHYRVARILIDLCSDVNV-CSLLAQTPLHVAAETG 648
G +N++T G +PL LAA GH ++L+D+ SD+N T L +A G
Sbjct: 1177 A-GAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQG 1235
Query: 649 HTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARG--PLNQTA 706
LLL R A E G T L AA G+ ++L+++ ADV A TA
Sbjct: 1236 RAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTA 1295
Query: 707 LHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHIN 762
L +AA GH + E L+ ID+ +++G + L LA+ G H V+ L++ GA ++
Sbjct: 1296 LTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVD 1352
Score = 112 bits (279), Expect = 2e-24
Identities = 81/278 (29%), Positives = 134/278 (48%), Gaps = 17/278 (6%)
Query: 431 VDLALDSGASL-----------LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAV 479
V++ LD G + L LA G++E LL AN N TPL +A
Sbjct: 1104 VEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAA 1163
Query: 480 ERRVRGVVELLLARKISVNAKDEDQW--TALHFAAQNGDESSTRLLLEKNASVN-EVDFE 536
++++LL +N++ + + L AA NG + +LLL+ + +N +++
Sbjct: 1164 SGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETN 1223
Query: 537 GRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVS 596
T + +AC G+ +V +LL R +V + K PL AA G+ + ++L + G
Sbjct: 1224 RNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDK-GAD 1282
Query: 597 VNAQTLDGR--TPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTAR 654
VNA + T L +AA +GHY+ +LI + ++V + TPL +A+ GH +
Sbjct: 1283 VNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQ 1342
Query: 655 LLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEE 692
LL+ GA +A + T L A R GH+ V+ LV+E
Sbjct: 1343 LLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
Score = 110 bits (276), Expect = 4e-24
Identities = 125/442 (28%), Positives = 188/442 (42%), Gaps = 19/442 (4%)
Query: 342 GVSQAVEGPEELSRSSSESKLPSSGSGKRLSGVSSVDSAFSSRGSLSLSFEREPSTSDLG 401
GV + + S + SSG G SG D+A + L+ + R
Sbjct: 36 GVGLGIRTVRLFGEAGPASGVGSSGGGGSGSGTGGGDAALDFK--LAAAVLRTGGGGGAS 93
Query: 402 TTDVQKKKLVDAIVSGDTSKLMKILQPQDVDLALDSGASLLHLAVEAGQEECAKWLLLNN 461
+D + V++ + D L + ++ L S A L + + LL
Sbjct: 94 GSDEDEVSEVESFIL-DQEDLDNPVLKTTSEIFLSSTAEGADLRTVDPETQARLEALLEA 152
Query: 462 AN-PNLSNRRGSTPLHMAVERRVRGVVELLL--ARKISVNAKDEDQWTA-------LHFA 511
A LS G V RR+ V L A K E+ A L A
Sbjct: 153 AGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEA 212
Query: 512 AQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQG-KDA 570
+GD ++ R LL++ SVNE EG + + +AC G + ++LL +V +G K
Sbjct: 213 CSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGD 272
Query: 571 WLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDV 630
PL A+ G+L IVKLL VN+Q+ G T L A G + ++L++ +++
Sbjct: 273 ITPLMAASSGGYLDIVKLLLLHDA-DVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 331
Query: 631 NVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSD-GYTALHLAARNGHLATVKLL 689
+ TPL AA GH AR+LL GAG +++ +AL LA GHL V+ L
Sbjct: 332 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFL 391
Query: 690 VEEKADVLARGPLNQTALHLAAAHGHSEVVEELV-SADVIDLFDEQGLSALHLAAQGRHA 748
+E AD + TAL A GH EV L+ S +++ + S L LAA G H
Sbjct: 392 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 451
Query: 749 QTVETLLRHGAHINLQSLKFQG 770
+ L+ GA NL+ + +G
Sbjct: 452 ELAALLIERGA--NLEEVNDEG 471
Score = 107 bits (267), Expect = 4e-23
Identities = 93/299 (31%), Positives = 133/299 (44%), Gaps = 7/299 (2%)
Query: 403 TDVQKKKLVDAIVSGDTSKLMKILQP-QDVDLALDSGASLLHLAVEAGQEECAKWLLLNN 461
TD L++A + G +L V++ DS S L LA G E A L+
Sbjct: 402 TDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERG 461
Query: 462 ANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDED-QWTALHFAAQNGDESST 520
AN N G TPL A +V LLLA+ ++NA+ E+ Q TAL A G
Sbjct: 462 ANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVA 521
Query: 521 RLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQ 580
L++ A +++ TP+ A Q G +V+ LL G +V L YA
Sbjct: 522 DFLIKAGA---DIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACEN 578
Query: 581 GHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQ-T 639
GH + +L Q G + ++ GRTPL AA+ GH + LI ++VN + T
Sbjct: 579 GHTDVADVLL-QAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHT 637
Query: 640 PLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLA 698
+ +A GH + LLL GA DG T L AA+ GH V L++ +VL+
Sbjct: 638 VVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLS 696
Score = 69.3 bits (168), Expect = 1e-11
Identities = 57/185 (30%), Positives = 78/185 (42%), Gaps = 32/185 (17%)
Query: 581 GHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQ-T 639
GH +V +L + + + G TPL LAA GH V IL+D D+ S + T
Sbjct: 1066 GHEELVSVLIARDA-KIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDT 1124
Query: 640 PLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLAR 699
PL +A G LLL RGA KE YT L LAA G++ +K+L+ A++ +R
Sbjct: 1125 PLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSR 1184
Query: 700 GPLNQTALHLAAAHGHSEVVEELVSADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGA 759
+ G+S L LAA H V+ LL G+
Sbjct: 1185 TG------------------------------SKLGISPLMLAAMNGHVPAVKLLLDMGS 1214
Query: 760 HINLQ 764
IN Q
Sbjct: 1215 DINAQ 1219
Score = 65.9 bits (159), Expect = 1e-10
Identities = 58/203 (28%), Positives = 87/203 (42%), Gaps = 3/203 (1%)
Query: 402 TTDVQKKKLVDAIVSGDTSKLMKILQPQDVDLALDSGASLLHLAVEAGQEECAKWLLLNN 461
T + Q+ L A G S++ L D+ L L+ + E G E K+LL +
Sbjct: 501 TEETQETALTLACCGG-FSEVADFLIKAGADIELGCSTPLMEASQE-GHLELVKYLLASG 558
Query: 462 ANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTR 521
AN + + G T L A E V ++LL + + E T L AA+ G + +
Sbjct: 559 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQ 618
Query: 522 LLLEKNASVNEVDFEG-RTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQ 580
L+ K A+VN T + +AC G +V +LL G D + + KD L AA
Sbjct: 619 FLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKG 678
Query: 581 GHLPIVKLLAKQPGVSVNAQTLD 603
GH +V L P ++ T D
Sbjct: 679 GHTNVVSYLLDYPNNVLSVPTTD 701
Score = 61.2 bits (147), Expect = 4e-09
Identities = 48/153 (31%), Positives = 72/153 (47%), Gaps = 12/153 (7%)
Query: 639 TPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLA 698
T L +A GH +L+ R A E G+T L LAA GH+ V++L+++ D+ A
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116
Query: 699 RGP-LNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLR 756
+ T L LA + G EVV+ L++ + + + L LAA G + ++ LL
Sbjct: 1117 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1176
Query: 757 HGAHINLQS----------LKFQGGHGPAATLL 779
GA IN ++ L GH PA LL
Sbjct: 1177 AGAEINSRTGSKLGISPLMLAAMNGHVPAVKLL 1209
>gi|40254844 receptor-interacting serine-threonine kinase 3 [Homo
sapiens]
Length = 518
Score = 151 bits (382), Expect = 2e-36
Identities = 98/284 (34%), Positives = 144/284 (50%), Gaps = 19/284 (6%)
Query: 21 EFTGWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMELLEEAKKMEMAKFRY 80
E E VG GGFG V++ +H W +A+K S + E K M +
Sbjct: 20 ELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAIS--------REVKAMASLDNEF 71
Query: 81 ILPVYGICRE-------PVGLVMEYMETGSLEKLLASE-PLPWDLRFRIIHETAVGMNFL 132
+L + G+ + LV ++ME GSL LL S+ P PW L R++ E +GM +L
Sbjct: 72 VLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRLLKEVVLGMFYL 131
Query: 133 HCMAPPLLHLDLKPANILLDAHYHVKISDFGLAKCNGLSHSHDLSMDGLFGTIAYLPPER 192
H P LLH DLKP+N+LLD HVK++DFGL+ G S S S + GT+ YL PE
Sbjct: 132 HDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEP-GGTLGYLAPEL 190
Query: 193 IREKSRLFDTKHDVYSFAIVIWGVLTQKKPFADEKNILHIMVKVVKGHRPELPPVCRARP 252
+R T DVYSF I++W VL ++ + L + +RP L + +A P
Sbjct: 191 FVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRPSLAELPQAGP 250
Query: 253 R--ACSHLIRLMQRCWQGDPRVRPTFQEITSETEDLCEKPDDEV 294
L LMQ CW +P+ RP+FQE +T+++ + ++ +
Sbjct: 251 ETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQMVENNM 294
>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
Length = 1430
Score = 150 bits (378), Expect = 6e-36
Identities = 175/689 (25%), Positives = 293/689 (42%), Gaps = 56/689 (8%)
Query: 26 EKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRER----MELLEEAKKMEMAKFRYI 81
E++GSG F V K R A K R ++ E ++ + +
Sbjct: 17 EELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIQHPNV 76
Query: 82 LPVYGIC--REPVGLVMEYMETGSLEKLLAS-EPLPWDLRFRIIHETAVGMNFLHCMAPP 138
+ ++ + + V L++E + G L LA E L + + + G+ +LH +
Sbjct: 77 ITLHEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYYLHSLQ-- 134
Query: 139 LLHLDLKPANI-LLDAHY---HVKISDFGLAKCNGLSHSHDLSMD--GLFGTIAYLPPER 192
+ H DLKP NI LLD + +KI DFGLA H D + +FGT ++ PE
Sbjct: 135 IAHFDLKPENIMLLDRNVPKPRIKIIDFGLA------HKIDFGNEFKNIFGTPEFVAPEI 188
Query: 193 IREKSRLFDTKHDVYSFAIVIWGVLTQKKPF-ADEKNILHIMVKVVKGHRPELPPVCRAR 251
+ + + D++S ++ + +L+ PF D K V V + E
Sbjct: 189 VNYEP--LGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVN-YEFEDEYFSNTS 245
Query: 252 PRACSHLIRLMQRCWQGDPRVRPTFQEITSETEDLCEKPDDEVKETAHDLDVKSPPEPRS 311
A + RL+ + DP+ R T Q D + P + K+T L K+ S
Sbjct: 246 ALAKDFIRRLLVK----DPKKRMTIQ-------DSLQHPWIKPKDTQQALSRKA-----S 289
Query: 312 EVVPARLKRASAPTFDNDYSLSELLSQLDSGVSQAVEGPEELSRSSSESKLPSSGSGKRL 371
V + K+ +A + S L L +S++ +S + S+ L S
Sbjct: 290 AVNMEKFKKFAAR---KKWKQSVRLISLCQRLSRSFLSRSNMSVARSDDTLDEEDSFVMK 346
Query: 372 SGVSSVDS-----AFSSRGSLSLSFEREPSTSDLGTTDVQKKKLVDAIVSGDTSKLMKIL 426
+ + +++ GSLS +P+ GT + L+ A + I
Sbjct: 347 AIIHAINDDNVPGLQHLLGSLSNYDVNQPNKH--GTPPL----LIAAGCGNIQILQLLIK 400
Query: 427 QPQDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGV 486
+ +D+ G++ ++ A G + K+L N ++ ++ G LH+A V
Sbjct: 401 RGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADV 460
Query: 487 VELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQ 546
+LL + + N +D+++ T LH AA +G S + L E +VN + EG TP+ A
Sbjct: 461 AQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASA 520
Query: 547 HGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRT 606
G +IV L G D++ KD + LH A + + ++K L Q G V+ Q G T
Sbjct: 521 RGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQ-GCFVDYQDRHGNT 579
Query: 607 PLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAM 666
PLH+A + G+ + L + ++++ + +TPLH+AA G R L GA EA+
Sbjct: 580 PLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEAL 639
Query: 667 TSDGYTALHLAARNGHLATVKLLVEEKAD 695
T+DG TA LA H LL + D
Sbjct: 640 TTDGKTAEDLARSEQHEHVAGLLARLRKD 668
Score = 134 bits (336), Expect = 4e-31
Identities = 83/299 (27%), Positives = 148/299 (49%), Gaps = 2/299 (0%)
Query: 459 LNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDES 518
L+N + N N+ G+ PL +A +++LL+ R ++ +D+ A+++AA++G
Sbjct: 367 LSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVD 426
Query: 519 STRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAA 578
+ + L E ++ D G +HVA ++G ++ ++L G + ++Q K+ PLH AA
Sbjct: 427 TLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAA 486
Query: 579 WQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQ 638
W G+ + K L + G +VN + +G TPL A+ RG++ + L + +D+N C
Sbjct: 487 WHGYYSVAKALC-EAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGH 545
Query: 639 TPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLA 698
LH+A + LL +G + G T LH+A ++G++ V L E ++
Sbjct: 546 IALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDI 605
Query: 699 RGPLNQTALHLAAAHGHSEVVEEL-VSADVIDLFDEQGLSALHLAAQGRHAQTVETLLR 756
+T LHLAA +G +VV L + ++ G +A LA +H L R
Sbjct: 606 SNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLLAR 664
Score = 115 bits (289), Expect = 1e-25
Identities = 83/289 (28%), Positives = 136/289 (47%), Gaps = 3/289 (1%)
Query: 475 LHMAVERRVRGVVELLLA-RKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEV 533
+H + V G+ LL + VN ++ L AA G+ +LL+++ + ++
Sbjct: 349 IHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQ 408
Query: 534 DFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQP 593
D G ++ A +HG + ++ L + ++ K + LH AA GH + +LL
Sbjct: 409 DKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSF- 467
Query: 594 GVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTA 653
G + N Q + TPLH AA G+Y VA+ L + +VN+ + +TPL A+ G+
Sbjct: 468 GSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIV 527
Query: 654 RLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAH 713
L GA A DG+ ALHLA R + +K L+ + V + T LH+A
Sbjct: 528 ECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKD 587
Query: 714 GHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHI 761
G+ +V L A+ +D+ ++ G + LHLAA V L GA +
Sbjct: 588 GNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASV 636
Score = 103 bits (256), Expect = 8e-22
Identities = 76/225 (33%), Positives = 98/225 (43%), Gaps = 3/225 (1%)
Query: 442 LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKD 501
LH A G AK L N N+ NR G TPL A R +VE L +NA D
Sbjct: 482 LHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACD 541
Query: 502 EDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGV 561
+D ALH A + + LL + V+ D G TP+HVAC+ G IV L
Sbjct: 542 KDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANC 601
Query: 562 DVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVAR 621
++ + K PLH AA G L +V+ L G SV A T DG+T LA H VA
Sbjct: 602 NLDISNKYGRTPLHLAANNGILDVVRYLCLM-GASVEALTTDGKTAEDLARSEQHEHVAG 660
Query: 622 ILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAM 666
+L L D + + Q L +L H G+GK +
Sbjct: 661 LLARLRKDTHRGLFIQQ--LRPTQNLQPRIKLKLFGHSGSGKTTL 703
Score = 90.1 bits (222), Expect = 7e-18
Identities = 62/204 (30%), Positives = 100/204 (49%), Gaps = 2/204 (0%)
Query: 562 DVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVAR 621
DV+ K PL AA G++ I++LL K+ G ++ Q G ++ AA+ GH +
Sbjct: 371 DVNQPNKHGTPPLLIAAGCGNIQILQLLIKR-GSRIDVQDKGGSNAVYWAARHGHVDTLK 429
Query: 622 ILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNG 681
L + ++V + LHVAA GH A+LL G+ + T LH AA +G
Sbjct: 430 FLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHG 489
Query: 682 HLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALH 740
+ + K L E +V + +T L A+A G+ ++VE L ++ D+ G ALH
Sbjct: 490 YYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALH 549
Query: 741 LAAQGRHAQTVETLLRHGAHINLQ 764
LA + + ++TLL G ++ Q
Sbjct: 550 LAVRRCQMEVIKTLLSQGCFVDYQ 573
>gi|34304381 inversin isoform a [Homo sapiens]
Length = 1065
Score = 145 bits (365), Expect = 2e-34
Identities = 111/380 (29%), Positives = 176/380 (46%), Gaps = 45/380 (11%)
Query: 430 DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVEL 489
DV+ S + LHLA + G K LL AN + TPLH+ R + L
Sbjct: 73 DVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLAL 132
Query: 490 LLARKI--SVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQH 547
LL V+ +D+++ TALH++A + +LL++ ++++ D EG+ P+H A H
Sbjct: 133 LLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANH 192
Query: 548 GQENIV---RILLRRGVDVSL---QGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQT 601
+ V R +L SL Q + PLH+A G++ +V +L ++ +
Sbjct: 193 KDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYD 252
Query: 602 LDGRTPLHLAAQRGHYRVARILIDLCSDVNVCS-LLAQTPLHVAAETGHTSTARLLLHRG 660
RTPLH AA GH ++ +L++ + S TPLH AA++ T ++ L
Sbjct: 253 NLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHP 312
Query: 661 AGKE--------------------------AMTSD---------GYTALHLAARNGHLAT 685
+ K+ ++ SD G TALH AA +GH++T
Sbjct: 313 SVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVST 372
Query: 686 VKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQ 744
VKLL+E A V A + T L A GH +V++ L+ +DL D+ G S LH AA
Sbjct: 373 VKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAAL 432
Query: 745 GRHAQTVETLLRHGAHINLQ 764
G +A + L+ + + N+Q
Sbjct: 433 GGNADVCQILIENKINPNVQ 452
Score = 125 bits (314), Expect = 2e-28
Identities = 110/370 (29%), Positives = 167/370 (45%), Gaps = 46/370 (12%)
Query: 439 ASLLHLAVEAGQEECAKWLLL-NNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISV 497
AS +H A G + + L++ N+A + ++ G TPL V + LL V
Sbjct: 15 ASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADV 74
Query: 498 NAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILL 557
N D Q TALH AAQ G+ +LLL + A+ + D E TP+H+ +H + +LL
Sbjct: 75 NKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLL 134
Query: 558 R--RGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQ------PGVS------------- 596
+ +V Q K+ LH++A+ + VKLL K P V
Sbjct: 135 KFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKD 194
Query: 597 -------------------VNAQTLDGRTPLHLAAQRGHYRVARILIDLCS-DVNVCSLL 636
+N Q +GRTPLH A G+ V +L S ++ L
Sbjct: 195 PSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNL 254
Query: 637 AQTPLHVAAETGHTSTARLLLHRG-AGKEAMTSDGYTALHLAARNGHLATVKLLVEEKAD 695
+TPLH AA GH LLL R +G S G T LH AA++ TVK+ ++ +
Sbjct: 255 FRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSV 314
Query: 696 VLARGPLNQTALHLAAAHGHSEVVEELVS--ADV-IDLFDEQGLSALHLAAQGRHAQTVE 752
+T+ AA G +V+ ++S +D+ I++ D+ G +ALH AA H TV+
Sbjct: 315 KDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVK 374
Query: 753 TLLRHGAHIN 762
LL + A ++
Sbjct: 375 LLLENNAQVD 384
Score = 119 bits (298), Expect = 1e-26
Identities = 96/385 (24%), Positives = 164/385 (42%), Gaps = 45/385 (11%)
Query: 422 LMKILQPQDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVER 481
L+K + P +VD + + LH + E K L+ +++N + + G PLH A
Sbjct: 133 LLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANH 192
Query: 482 R-------VRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLE-KNASVNEV 533
+ VR +++ + +N +D + T LHFA +G+ + +L ++ ++
Sbjct: 193 KDPSAVHTVRCILDAAPTESL-LNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSY 251
Query: 534 DFEGRTPMHVACQHGQENIVRILLRRGVDVSLQG-KDAWLPLHYAAWQGHLPIVKLLAKQ 592
D RTP+H A G IV +LL R ++ PLHYAA VK+ K
Sbjct: 252 DNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKH 311
Query: 593 PGVS----------------------------------VNAQTLDGRTPLHLAAQRGHYR 618
P V +N G T LH AA GH
Sbjct: 312 PSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVS 371
Query: 619 VARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAA 678
++L++ + V+ ++ TPL A E GH + L+ GA + + DG++ LH AA
Sbjct: 372 TVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAA 431
Query: 679 RNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLS 737
G+ ++L+E K + + +T L AA G+ + L+ + ++ D++G +
Sbjct: 432 LGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRT 491
Query: 738 ALHLAAQGRHAQTVETLLRHGAHIN 762
ALH + + ++ LL A N
Sbjct: 492 ALHWSCNNGYLDAIKLLLDFAAFPN 516
Score = 111 bits (278), Expect = 2e-24
Identities = 78/261 (29%), Positives = 128/261 (49%), Gaps = 5/261 (1%)
Query: 438 GASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARK--I 495
GA+ LH A ++ E K L + + + S+ G T A + V+ +L+ K I
Sbjct: 289 GATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDI 348
Query: 496 SVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRI 555
+N D+ TALH AA +G S+ +LLLE NA V+ D TP+ AC+ G +++++
Sbjct: 349 DINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQT 408
Query: 556 LLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRG 615
L++ G V L +D LH+AA G+ + ++L + ++ N Q GRTPL AA G
Sbjct: 409 LIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENK-INPNVQDYAGRTPLQCAAYGG 467
Query: 616 HYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAM--TSDGYTA 673
+ +L++ +D N+ +T LH + G+ +LLL A M + YT
Sbjct: 468 YINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTP 527
Query: 674 LHLAARNGHLATVKLLVEEKA 694
L A ++ ++E A
Sbjct: 528 LDYALLGERHEVIQFMLEHGA 548
Score = 90.5 bits (223), Expect = 5e-18
Identities = 60/212 (28%), Positives = 102/212 (48%), Gaps = 2/212 (0%)
Query: 416 SGDTSKLMKILQPQ-DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTP 474
S D + M L+ D+++A G + LH A +G K LL NNA + ++ TP
Sbjct: 334 SDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTP 393
Query: 475 LHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVD 534
L A E + V++ L+ V+ D+D + LH+AA G+ ++L+E + N D
Sbjct: 394 LFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQD 453
Query: 535 FEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPG 594
+ GRTP+ A G N + +L+ D ++Q K+ LH++ G+L +KLL
Sbjct: 454 YAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAA 513
Query: 595 VSVNAQTLDGR-TPLHLAAQRGHYRVARILID 625
+ + R TPL A + V + +++
Sbjct: 514 FPNQMENNEERYTPLDYALLGERHEVIQFMLE 545
>gi|34304379 inversin isoform b [Homo sapiens]
Length = 895
Score = 145 bits (365), Expect = 2e-34
Identities = 111/380 (29%), Positives = 176/380 (46%), Gaps = 45/380 (11%)
Query: 430 DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVEL 489
DV+ S + LHLA + G K LL AN + TPLH+ R + L
Sbjct: 73 DVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLAL 132
Query: 490 LLARKI--SVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQH 547
LL V+ +D+++ TALH++A + +LL++ ++++ D EG+ P+H A H
Sbjct: 133 LLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANH 192
Query: 548 GQENIV---RILLRRGVDVSL---QGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQT 601
+ V R +L SL Q + PLH+A G++ +V +L ++ +
Sbjct: 193 KDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYD 252
Query: 602 LDGRTPLHLAAQRGHYRVARILIDLCSDVNVCS-LLAQTPLHVAAETGHTSTARLLLHRG 660
RTPLH AA GH ++ +L++ + S TPLH AA++ T ++ L
Sbjct: 253 NLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHP 312
Query: 661 AGKE--------------------------AMTSD---------GYTALHLAARNGHLAT 685
+ K+ ++ SD G TALH AA +GH++T
Sbjct: 313 SVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVST 372
Query: 686 VKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQ 744
VKLL+E A V A + T L A GH +V++ L+ +DL D+ G S LH AA
Sbjct: 373 VKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAAL 432
Query: 745 GRHAQTVETLLRHGAHINLQ 764
G +A + L+ + + N+Q
Sbjct: 433 GGNADVCQILIENKINPNVQ 452
Score = 125 bits (314), Expect = 2e-28
Identities = 110/370 (29%), Positives = 167/370 (45%), Gaps = 46/370 (12%)
Query: 439 ASLLHLAVEAGQEECAKWLLL-NNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISV 497
AS +H A G + + L++ N+A + ++ G TPL V + LL V
Sbjct: 15 ASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADV 74
Query: 498 NAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILL 557
N D Q TALH AAQ G+ +LLL + A+ + D E TP+H+ +H + +LL
Sbjct: 75 NKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLL 134
Query: 558 R--RGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQ------PGVS------------- 596
+ +V Q K+ LH++A+ + VKLL K P V
Sbjct: 135 KFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKD 194
Query: 597 -------------------VNAQTLDGRTPLHLAAQRGHYRVARILIDLCS-DVNVCSLL 636
+N Q +GRTPLH A G+ V +L S ++ L
Sbjct: 195 PSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNL 254
Query: 637 AQTPLHVAAETGHTSTARLLLHRG-AGKEAMTSDGYTALHLAARNGHLATVKLLVEEKAD 695
+TPLH AA GH LLL R +G S G T LH AA++ TVK+ ++ +
Sbjct: 255 FRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSV 314
Query: 696 VLARGPLNQTALHLAAAHGHSEVVEELVS--ADV-IDLFDEQGLSALHLAAQGRHAQTVE 752
+T+ AA G +V+ ++S +D+ I++ D+ G +ALH AA H TV+
Sbjct: 315 KDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVK 374
Query: 753 TLLRHGAHIN 762
LL + A ++
Sbjct: 375 LLLENNAQVD 384
Score = 119 bits (298), Expect = 1e-26
Identities = 96/385 (24%), Positives = 164/385 (42%), Gaps = 45/385 (11%)
Query: 422 LMKILQPQDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVER 481
L+K + P +VD + + LH + E K L+ +++N + + G PLH A
Sbjct: 133 LLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANH 192
Query: 482 R-------VRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLE-KNASVNEV 533
+ VR +++ + +N +D + T LHFA +G+ + +L ++ ++
Sbjct: 193 KDPSAVHTVRCILDAAPTESL-LNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSY 251
Query: 534 DFEGRTPMHVACQHGQENIVRILLRRGVDVSLQG-KDAWLPLHYAAWQGHLPIVKLLAKQ 592
D RTP+H A G IV +LL R ++ PLHYAA VK+ K
Sbjct: 252 DNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKH 311
Query: 593 PGVS----------------------------------VNAQTLDGRTPLHLAAQRGHYR 618
P V +N G T LH AA GH
Sbjct: 312 PSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVS 371
Query: 619 VARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAA 678
++L++ + V+ ++ TPL A E GH + L+ GA + + DG++ LH AA
Sbjct: 372 TVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAA 431
Query: 679 RNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLS 737
G+ ++L+E K + + +T L AA G+ + L+ + ++ D++G +
Sbjct: 432 LGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRT 491
Query: 738 ALHLAAQGRHAQTVETLLRHGAHIN 762
ALH + + ++ LL A N
Sbjct: 492 ALHWSCNNGYLDAIKLLLDFAAFPN 516
Score = 111 bits (278), Expect = 2e-24
Identities = 78/261 (29%), Positives = 128/261 (49%), Gaps = 5/261 (1%)
Query: 438 GASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARK--I 495
GA+ LH A ++ E K L + + + S+ G T A + V+ +L+ K I
Sbjct: 289 GATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDI 348
Query: 496 SVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRI 555
+N D+ TALH AA +G S+ +LLLE NA V+ D TP+ AC+ G +++++
Sbjct: 349 DINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQT 408
Query: 556 LLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRG 615
L++ G V L +D LH+AA G+ + ++L + ++ N Q GRTPL AA G
Sbjct: 409 LIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENK-INPNVQDYAGRTPLQCAAYGG 467
Query: 616 HYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAM--TSDGYTA 673
+ +L++ +D N+ +T LH + G+ +LLL A M + YT
Sbjct: 468 YINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTP 527
Query: 674 LHLAARNGHLATVKLLVEEKA 694
L A ++ ++E A
Sbjct: 528 LDYALLGERHEVIQFMLEHGA 548
Score = 90.5 bits (223), Expect = 5e-18
Identities = 60/212 (28%), Positives = 102/212 (48%), Gaps = 2/212 (0%)
Query: 416 SGDTSKLMKILQPQ-DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTP 474
S D + M L+ D+++A G + LH A +G K LL NNA + ++ TP
Sbjct: 334 SDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTP 393
Query: 475 LHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVD 534
L A E + V++ L+ V+ D+D + LH+AA G+ ++L+E + N D
Sbjct: 394 LFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQD 453
Query: 535 FEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPG 594
+ GRTP+ A G N + +L+ D ++Q K+ LH++ G+L +KLL
Sbjct: 454 YAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAA 513
Query: 595 VSVNAQTLDGR-TPLHLAAQRGHYRVARILID 625
+ + R TPL A + V + +++
Sbjct: 514 FPNQMENNEERYTPLDYALLGERHEVIQFMLE 545
>gi|96975023 ankyrin repeat and death domain containing 1A [Homo
sapiens]
Length = 522
Score = 143 bits (360), Expect = 7e-34
Identities = 107/366 (29%), Positives = 179/366 (48%), Gaps = 24/366 (6%)
Query: 438 GASLLHLAVEAGQEECAKWLLLNNANPN-------LSNRR---GSTPLHMAVERRVRGVV 487
G LH A AG E+ + LL + A + L+ R G L ++ ++
Sbjct: 48 GRVALHWAAGAGHEQAVRLLLEHEAAVDEEDAVGALTEARLCFGMNALLLSAWFGHLRIL 107
Query: 488 ELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLE--KNASVNEVDFEGRTPMHVAC 545
++L+ ++ + +D T LH AAQ G ++E ++ +++ VD GRT H A
Sbjct: 108 QILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAA 167
Query: 546 QHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGR 605
+HGQ + + L+ G D +++ K+ LH AA +GH+ +++ L G+ + Q +G
Sbjct: 168 EHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLV-DIGLDLEEQNAEGL 226
Query: 606 TPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEA 665
T LH AA H ++L+ S VN + + LH AA +G +R+L+H G
Sbjct: 227 TALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANV 286
Query: 666 MTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSA 725
+ G + LHLA R+ A V+LL+ +DV A QT LHLAA H ++ + L+ A
Sbjct: 287 VDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIA 346
Query: 726 DV-IDLFDEQGLSALHLAAQGRHAQTVETLLR----------HGAHINLQSLKFQGGHGP 774
V ++L D+QG +AL +A + H V+ +++ H + + +SL F+ H
Sbjct: 347 GVDLNLRDKQGKTALAVAVRSNHVSLVDMIIKADRFYRWEKDHPSDPSGKSLSFKQDHRQ 406
Query: 775 AATLLR 780
LR
Sbjct: 407 ETQQLR 412
Score = 131 bits (329), Expect = 3e-30
Identities = 93/300 (31%), Positives = 143/300 (47%), Gaps = 12/300 (4%)
Query: 475 LHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVD 534
LH A + G ++ L+ R+++ A++ ALH+AA G E + RLLLE A+V+E D
Sbjct: 19 LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78
Query: 535 FE----------GRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLP 584
G + ++ G I++IL+ G + + KD LH AA +GH+P
Sbjct: 79 AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVP 138
Query: 585 IVKLLAKQ-PGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHV 643
++ + + V+++ GRT H AA+ G L+ D NV T LH+
Sbjct: 139 VLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHL 198
Query: 644 AAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLN 703
AA GH + + L+ G E ++G TALH AA H V+LL+ + V A N
Sbjct: 199 AAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKN 258
Query: 704 QTALHLAAAHGHSEVVEELVSA-DVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHIN 762
+ LH AA G +V L+ A ++ D QG S LHLA + V L+ + +N
Sbjct: 259 LSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVN 318
Score = 95.5 bits (236), Expect = 2e-19
Identities = 65/230 (28%), Positives = 112/230 (48%), Gaps = 5/230 (2%)
Query: 432 DLALDS----GASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVV 487
D+ALD G + H A E GQ + +L+ + + N+ ++ G+T LH+A R V+
Sbjct: 149 DVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVL 208
Query: 488 ELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQH 547
+ L+ + + ++ + TALH AA +LLL ++VN + + + +H A
Sbjct: 209 QRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALS 268
Query: 548 GQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTP 607
G E++ R+L+ G ++ PLH A +V+LL VNA +TP
Sbjct: 269 GSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDS-DVNAVDNRQQTP 327
Query: 608 LHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLL 657
LHLAA+ +A +L+ D+N+ +T L VA + H S +++
Sbjct: 328 LHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMII 377
Score = 65.1 bits (157), Expect = 2e-10
Identities = 37/128 (28%), Positives = 66/128 (51%)
Query: 431 VDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELL 490
V+ S LH A +G E+ ++ L+ N+ + +G++PLH+AV +V LL
Sbjct: 251 VNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLL 310
Query: 491 LARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQE 550
+ VNA D Q T LH AA++ + +LL +N D +G+T + VA +
Sbjct: 311 INSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHV 370
Query: 551 NIVRILLR 558
++V ++++
Sbjct: 371 SLVDMIIK 378
Score = 33.5 bits (75), Expect = 0.78
Identities = 22/72 (30%), Positives = 41/72 (56%), Gaps = 2/72 (2%)
Query: 422 LMKILQPQDVDL-ALDSGASL-LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAV 479
L+++L D D+ A+D+ LHLA E ++ A LL+ + NL +++G T L +AV
Sbjct: 306 LVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAV 365
Query: 480 ERRVRGVVELLL 491
+V++++
Sbjct: 366 RSNHVSLVDMII 377
>gi|223634006 hypothetical protein LOC441869 [Homo sapiens]
Length = 399
Score = 142 bits (357), Expect = 2e-33
Identities = 112/351 (31%), Positives = 159/351 (45%), Gaps = 25/351 (7%)
Query: 447 EAGQEECAKWLLLNNANPNLSNRRGSTPLH------MAVERRVRGVVELLLARKISVNAK 500
E +E+ +W+ L++ + G + + AV R G+V LL + SV +
Sbjct: 11 EEEEEQELRWMELDSEEALGTRTEGPSVVQGWGHLLQAVWRGPAGLVTQLLRQGASVEER 70
Query: 501 DEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRG 560
D T LH A G RLLL++ A V VD GRT +H A HG + +LL+RG
Sbjct: 71 DHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRG 130
Query: 561 VDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPG---VSVNAQTLDGRTPLHLAAQRGHY 617
+ + PLH+AA GH + L + PG + A+ G T H AA G
Sbjct: 131 ASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRL 190
Query: 618 RVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLA 677
V +L + ++ L VAA G + R LL RGA +A G TAL LA
Sbjct: 191 AVLELLAAGGAGLDGALL-------VAAAAGRGAALRFLLARGARVDARDGAGATALGLA 243
Query: 678 ARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGL 736
A G +++L+ AD R ++ALH AAA GH V+ LV+ +D D GL
Sbjct: 244 AALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGL 303
Query: 737 SALHLAAQGRHAQTVETLLRHGAHINLQS--------LKFQGGHGPAATLL 779
+ LH A++ H + LL GA ++ L + GHGP LL
Sbjct: 304 TPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLL 354
Score = 120 bits (301), Expect = 5e-27
Identities = 101/309 (32%), Positives = 137/309 (44%), Gaps = 29/309 (9%)
Query: 445 AVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQ 504
AV G LL A+ + G TPLH+AV R +V LLL R V A D
Sbjct: 48 AVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAG 107
Query: 505 WTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVD-- 562
TALH AA +G LLL++ AS G TP+H A G + LL
Sbjct: 108 RTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGP 167
Query: 563 VSLQGKDA--WLPLHYAAWQGHLPIVKLLAK-------------------------QPGV 595
+ + +DA W H+AA G L +++LLA G
Sbjct: 168 AAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGALLVAAAAGRGAALRFLLARGA 227
Query: 596 SVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARL 655
V+A+ G T L LAA G + +L+ +D + ++ LH AA GH +L
Sbjct: 228 RVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQL 287
Query: 656 LLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGH 715
L+ +GA +A + G T LH A+R GH+ L++ A V A G L +T LHLAA GH
Sbjct: 288 LVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGH 347
Query: 716 SEVVEELVS 724
V L+S
Sbjct: 348 GPTVGLLLS 356
Score = 113 bits (282), Expect = 8e-25
Identities = 92/291 (31%), Positives = 131/291 (45%), Gaps = 42/291 (14%)
Query: 413 AIVSGDTSKLMKILQPQDVDLALD-SGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRG 471
A++ G + +LQ A+D +G + LH A G A+ LL A+ + G
Sbjct: 81 AVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTG 140
Query: 472 STPLHMAVERRVRGVVELLLARKI---------SVNAKDEDQWTALHFAAQNGD------ 516
TPLH A + LLA ++ + A+D WTA H+AA G
Sbjct: 141 LTPLHWAA-----ALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLEL 195
Query: 517 --------------------ESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRIL 556
++ R LL + A V+ D G T + +A G+ + +L
Sbjct: 196 LAAGGAGLDGALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVL 255
Query: 557 LRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGH 616
L G D ++ + LH AA +GHL V+LL Q G V+A+ G TPLH A++ GH
Sbjct: 256 LGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQ-GAEVDARDTLGLTPLHHASREGH 314
Query: 617 YRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMT 667
VA L+D + V+ L +TPLH+AAE GH T LLL RGA T
Sbjct: 315 VEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTLRT 365
Score = 101 bits (252), Expect = 2e-21
Identities = 99/321 (30%), Positives = 129/321 (40%), Gaps = 32/321 (9%)
Query: 410 LVDAIVSGDTSKLMKIL-QPQDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSN 468
L+ A+ G + ++L Q V+ +G + LHLAV G + LL A +
Sbjct: 45 LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVD 104
Query: 469 RRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKN- 527
R G T LH A V ELLL R S A+ T LH+AA G LLE
Sbjct: 105 RAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPG 164
Query: 528 ---ASVNEVDFEGRTPMH--------------------------VACQHGQENIVRILLR 558
A+ D G T H VA G+ +R LL
Sbjct: 165 PGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGALLVAAAAGRGAALRFLLA 224
Query: 559 RGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYR 618
RG V + L AA G +++L G + GR+ LH AA RGH
Sbjct: 225 RGARVDARDGAGATALGLAAALGRSQDIEVLLGH-GADPGIRDRHGRSALHRAAARGHLL 283
Query: 619 VARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAA 678
++L+ ++V+ L TPLH A+ GH A LL RGA +A T LHLAA
Sbjct: 284 AVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAA 343
Query: 679 RNGHLATVKLLVEEKADVLAR 699
GH TV LL+ A R
Sbjct: 344 ERGHGPTVGLLLSRGASPTLR 364
>gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]
Length = 835
Score = 137 bits (345), Expect = 4e-32
Identities = 103/340 (30%), Positives = 167/340 (49%), Gaps = 19/340 (5%)
Query: 436 DSGASLLHLA-VEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARK 494
++G SLLHL + G++ + L+L P+ R G T LH+AV + ++ LL
Sbjct: 65 ENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSG 124
Query: 495 ISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVR 554
+ TALH A G + +LL+ A+VN D TP+H+A +G E + R
Sbjct: 125 ADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTR 184
Query: 555 ILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPG-VSVNAQTLDGRTPLHLAAQ 613
+LL+ G DV++ G+ PLH A+ +G L I KLL ++ VNAQ + PLH ++
Sbjct: 185 LLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSR 244
Query: 614 RGHYRVARILI--DLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGY 671
GH+ + + L+ DL +V ++ TPLH+A G A+ ++ + +G E++T +
Sbjct: 245 FGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEII-QISGTESLTKENI 303
Query: 672 ---TALHLAARNG-HLATVKLLVEEKA-DVLARGPLNQTALHLAAAHGHSEVVE------ 720
TA H A G + VK L+++ ++ +G T LH A HGH +V+
Sbjct: 304 FSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNG 363
Query: 721 ---ELVSADVIDLFDEQGLSALHLAAQGRHAQTVETLLRH 757
LV+ D E+ + A + + TLL+H
Sbjct: 364 ADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLLKH 403
Score = 119 bits (297), Expect = 1e-26
Identities = 95/351 (27%), Positives = 157/351 (44%), Gaps = 28/351 (7%)
Query: 460 NNANPNLSNRRGSTPLHMA-VERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDES 518
+ N N G + LH+ + + + L+ + + + + +TALH A +
Sbjct: 56 SKVNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAE 115
Query: 519 STRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAA 578
LL A + +V + G T +H+A G +LL+ G +V++Q + PLH AA
Sbjct: 116 LITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAA 175
Query: 579 WQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCS--DVNVCSLL 636
+ GH + +LL K G VN G PLHLA+ +G +A++L++ S DVN
Sbjct: 176 YYGHEQVTRLLLKF-GADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNE 234
Query: 637 AQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGY--TALHLAARNGHLATVKLLVEEKA 694
PLH + GH + LL + + Y T LHLA NG K +++
Sbjct: 235 DHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISG 294
Query: 695 --DVLARGPLNQTALHLAAAHGHS-EVVEELVSADVIDLFDE--QGLSALHLAAQGRHAQ 749
+ ++TA H A +G S ++V+ L+ +VI++ + G + LH A H +
Sbjct: 295 TESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIR 354
Query: 750 TVETLLRHGAHINLQSL-----------------KFQGGHGPAATLLRRSK 783
V+ LL +GA +NL + ++ GH TLL+ K
Sbjct: 355 LVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLLKHYK 405
Score = 87.0 bits (214), Expect = 6e-17
Identities = 76/269 (28%), Positives = 129/269 (47%), Gaps = 18/269 (6%)
Query: 26 EKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMELL-EEAKKMEMAKFRYILPV 84
E +GSG FG+VYK R + +AIK + + +++ E + ++
Sbjct: 467 EIIGSGSFGKVYKGRCRN--KIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQF 524
Query: 85 YGIC-REP--VGLVMEYMETGSLEKLLASEPLPWDLRFRIIH--ETAVGMNFLHCMAPPL 139
G C +P +V +Y+ GSL LL + DL+ ++I + A GM +LH + P+
Sbjct: 525 VGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHNLTQPI 584
Query: 140 LHLDLKPANILLDAHYHVKISDFGLAKCNGLSHSHDLSMDGLFGTIAYLPPERIREKSRL 199
+H DL NILL H ++DFG ++ L + +M G + ++ PE + +R
Sbjct: 585 IHRDLNSHNILLYEDGHAVVADFGESRF--LQSLDEDNMTKQPGNLRWMAPEVFTQCTR- 641
Query: 200 FDTKHDVYSFAIVIWGVLTQKKPFADEKNILHIMVKVVKGHRPELPPVCRARPRACSHLI 259
+ K DV+S+A+ +W +LT + PFA ++ + PP+ + P+ S
Sbjct: 642 YTIKADVFSYALCLWEILTGEIPFA---HLKPAAAAADMAYHHIRPPIGYSIPKPIS--- 695
Query: 260 RLMQRCWQGDPRVRPTFQEITSETED-LC 287
L+ R W P RP F E+ + E+ LC
Sbjct: 696 SLLIRGWNACPEGRPEFSEVVMKLEECLC 724
>gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]
Length = 936
Score = 137 bits (345), Expect = 4e-32
Identities = 103/340 (30%), Positives = 167/340 (49%), Gaps = 19/340 (5%)
Query: 436 DSGASLLHLA-VEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARK 494
++G SLLHL + G++ + L+L P+ R G T LH+AV + ++ LL
Sbjct: 166 ENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSG 225
Query: 495 ISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVR 554
+ TALH A G + +LL+ A+VN D TP+H+A +G E + R
Sbjct: 226 ADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTR 285
Query: 555 ILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPG-VSVNAQTLDGRTPLHLAAQ 613
+LL+ G DV++ G+ PLH A+ +G L I KLL ++ VNAQ + PLH ++
Sbjct: 286 LLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSR 345
Query: 614 RGHYRVARILI--DLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGY 671
GH+ + + L+ DL +V ++ TPLH+A G A+ ++ + +G E++T +
Sbjct: 346 FGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEII-QISGTESLTKENI 404
Query: 672 ---TALHLAARNG-HLATVKLLVEEKA-DVLARGPLNQTALHLAAAHGHSEVVE------ 720
TA H A G + VK L+++ ++ +G T LH A HGH +V+
Sbjct: 405 FSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNG 464
Query: 721 ---ELVSADVIDLFDEQGLSALHLAAQGRHAQTVETLLRH 757
LV+ D E+ + A + + TLL+H
Sbjct: 465 ADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLLKH 504
Score = 119 bits (297), Expect = 1e-26
Identities = 95/351 (27%), Positives = 157/351 (44%), Gaps = 28/351 (7%)
Query: 460 NNANPNLSNRRGSTPLHMA-VERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDES 518
+ N N G + LH+ + + + L+ + + + + +TALH A +
Sbjct: 157 SKVNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAE 216
Query: 519 STRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAA 578
LL A + +V + G T +H+A G +LL+ G +V++Q + PLH AA
Sbjct: 217 LITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAA 276
Query: 579 WQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCS--DVNVCSLL 636
+ GH + +LL K G VN G PLHLA+ +G +A++L++ S DVN
Sbjct: 277 YYGHEQVTRLLLKF-GADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNE 335
Query: 637 AQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGY--TALHLAARNGHLATVKLLVEEKA 694
PLH + GH + LL + + Y T LHLA NG K +++
Sbjct: 336 DHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISG 395
Query: 695 --DVLARGPLNQTALHLAAAHGHS-EVVEELVSADVIDLFDE--QGLSALHLAAQGRHAQ 749
+ ++TA H A +G S ++V+ L+ +VI++ + G + LH A H +
Sbjct: 396 TESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIR 455
Query: 750 TVETLLRHGAHINLQSL-----------------KFQGGHGPAATLLRRSK 783
V+ LL +GA +NL + ++ GH TLL+ K
Sbjct: 456 LVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLLKHYK 506
Score = 87.0 bits (214), Expect = 6e-17
Identities = 76/269 (28%), Positives = 129/269 (47%), Gaps = 18/269 (6%)
Query: 26 EKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMELL-EEAKKMEMAKFRYILPV 84
E +GSG FG+VYK R + +AIK + + +++ E + ++
Sbjct: 568 EIIGSGSFGKVYKGRCRN--KIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQF 625
Query: 85 YGIC-REP--VGLVMEYMETGSLEKLLASEPLPWDLRFRIIH--ETAVGMNFLHCMAPPL 139
G C +P +V +Y+ GSL LL + DL+ ++I + A GM +LH + P+
Sbjct: 626 VGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHNLTQPI 685
Query: 140 LHLDLKPANILLDAHYHVKISDFGLAKCNGLSHSHDLSMDGLFGTIAYLPPERIREKSRL 199
+H DL NILL H ++DFG ++ L + +M G + ++ PE + +R
Sbjct: 686 IHRDLNSHNILLYEDGHAVVADFGESRF--LQSLDEDNMTKQPGNLRWMAPEVFTQCTR- 742
Query: 200 FDTKHDVYSFAIVIWGVLTQKKPFADEKNILHIMVKVVKGHRPELPPVCRARPRACSHLI 259
+ K DV+S+A+ +W +LT + PFA ++ + PP+ + P+ S
Sbjct: 743 YTIKADVFSYALCLWEILTGEIPFA---HLKPAAAAADMAYHHIRPPIGYSIPKPIS--- 796
Query: 260 RLMQRCWQGDPRVRPTFQEITSETED-LC 287
L+ R W P RP F E+ + E+ LC
Sbjct: 797 SLLIRGWNACPEGRPEFSEVVMKLEECLC 825
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.133 0.396
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,891,074
Number of Sequences: 37866
Number of extensions: 1420028
Number of successful extensions: 12908
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 800
Number of HSP's successfully gapped in prelim test: 358
Number of HSP's that attempted gapping in prelim test: 4079
Number of HSP's gapped (non-prelim): 3566
length of query: 784
length of database: 18,247,518
effective HSP length: 110
effective length of query: 674
effective length of database: 14,082,258
effective search space: 9491441892
effective search space used: 9491441892
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.