Search of human proteins with 41327752

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|41327752 diabetes related ankyrin repeat protein [Homo
sapiens]
         (305 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|41327752 diabetes related ankyrin repeat protein [Homo sapiens]    624   e-179
gi|38327522 cardiac ankyrin repeat protein [Homo sapiens]             233   1e-61
gi|39812133 ankyrin repeat domain 2 isoform a [Homo sapiens]          207   9e-54
gi|194018403 ankyrin repeat domain 2 isoform b [Homo sapiens]         149   3e-36
gi|24233530 ankyrin repeat domain 44 [Homo sapiens]                   105   5e-23
gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo ...   102   3e-22
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]                         97   1e-20
gi|68131557 ankyrin repeat domain 28 [Homo sapiens]                    97   2e-20
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]                        96   3e-20
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]                         96   3e-20
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]                         96   3e-20
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]                         96   3e-20
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]                         96   3e-20
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi...    95   7e-20
gi|157743284 ankyrin repeat domain 52 [Homo sapiens]                   92   4e-19
gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens]     91   1e-18
gi|34304381 inversin isoform a [Homo sapiens]                          89   4e-18
gi|34304379 inversin isoform b [Homo sapiens]                          89   4e-18
gi|62988328 ankyrin repeat domain 50 [Homo sapiens]                    88   8e-18
gi|222537750 ankyrin repeat domain 30B [Homo sapiens]                  87   1e-17
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ...    87   1e-17
gi|70995241 ankyrin repeat domain 10 [Homo sapiens]                    87   2e-17
gi|89363047 death-associated protein kinase 1 [Homo sapiens]           86   4e-17
gi|55742857 ankyrin repeat domain 6 [Homo sapiens]                     85   7e-17
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]                        84   1e-16
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]                         84   1e-16
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]                         84   1e-16
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ...    83   3e-16
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]                     83   3e-16
gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled...    83   3e-16

>gi|41327752 diabetes related ankyrin repeat protein [Homo sapiens]
          Length = 305

 Score =  624 bits (1608), Expect = e-179
 Identities = 305/305 (100%), Positives = 305/305 (100%)

Query: 1   MDFISIQQLVSGERVEGKVLGFGHGVPDPGAWPSDWRRGPQEAVAREKLKLEEEKKKKLE 60
           MDFISIQQLVSGERVEGKVLGFGHGVPDPGAWPSDWRRGPQEAVAREKLKLEEEKKKKLE
Sbjct: 1   MDFISIQQLVSGERVEGKVLGFGHGVPDPGAWPSDWRRGPQEAVAREKLKLEEEKKKKLE 60

Query: 61  RFNSTRFNLDNLADLENLVQRRKKRLRHRVPPRKPEPLVKPQSQAQVEPVGLEMFLKAAA 120
           RFNSTRFNLDNLADLENLVQRRKKRLRHRVPPRKPEPLVKPQSQAQVEPVGLEMFLKAAA
Sbjct: 61  RFNSTRFNLDNLADLENLVQRRKKRLRHRVPPRKPEPLVKPQSQAQVEPVGLEMFLKAAA 120

Query: 121 ENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTP 180
           ENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTP
Sbjct: 121 ENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTP 180

Query: 181 VFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQD 240
           VFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQD
Sbjct: 181 VFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQD 240

Query: 241 KEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLARDWQRGIREALQAHVAH 300
           KEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLARDWQRGIREALQAHVAH
Sbjct: 241 KEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLARDWQRGIREALQAHVAH 300

Query: 301 PRTRC 305
           PRTRC
Sbjct: 301 PRTRC 305


>gi|38327522 cardiac ankyrin repeat protein [Homo sapiens]
          Length = 319

 Score =  233 bits (595), Expect = 1e-61
 Identities = 134/305 (43%), Positives = 188/305 (61%), Gaps = 36/305 (11%)

Query: 14  RVEGKVLGFGHGVPDPGAW-PSDWRRGPQEAVAR------------------------EK 48
           +VE  V G  +G  + G + P D+R G  EA                           EK
Sbjct: 5   KVEELVTGKKNGNGEAGEFLPEDFRDGEYEAAVTLEKQEDLKTLLAHPVTLGEQQWKSEK 64

Query: 49  LKLEEEKKKKLERFNSTRFNLDNLADLENLVQ--RRKKRLRHRVPPRKPEPLVKPQSQAQ 106
            +  E KKKKLE+    R  L+NL DLE ++Q  +RKK  + +VP  K     +P+ +  
Sbjct: 65  QREAELKKKKLEQ----RSKLENLEDLEIIIQLKKRKKYRKTKVPVVK-----EPEPEII 115

Query: 107 VEPVGLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVA 166
            EPV +  FLKAA EN+  +++K+L+D  +P+  D+  RTALH ACL+GH  +V KL+ A
Sbjct: 116 TEPVDVPTFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEA 175

Query: 167 GATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCL 226
           GA ++ RD+L+ T + WA RGG+L +LK LLN+GA+++ARDK+ ST LHVAVRT H +C 
Sbjct: 176 GAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECA 235

Query: 227 EHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLARDW 286
           EHLI C A LNA+D+EGDT LH+AVR   YK ++LL++YGA+L ++N A  TP+ L   W
Sbjct: 236 EHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLHW 295

Query: 287 QRGIR 291
           Q G +
Sbjct: 296 QNGTK 300


>gi|39812133 ankyrin repeat domain 2 isoform a [Homo sapiens]
          Length = 360

 Score =  207 bits (527), Expect = 9e-54
 Identities = 111/246 (45%), Positives = 153/246 (62%), Gaps = 4/246 (1%)

Query: 54  EKKKKLERFNSTRFNLD----NLADLENLVQRRKKRLRHRVPPRKPEPLVKPQSQAQVEP 109
           +K K  ER   T  +L     ++  ++NL++ RKKR + +           P+ +    P
Sbjct: 87  QKVKGQERVRKTSLDLRREIIDVGGIQNLIELRKKRKQKKRDALAASHEPPPEPEEITGP 146

Query: 110 VGLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGAT 169
           V  E FLKAA E +  +I+K+L DGG  +  D+  RTALH A L+GH +++ KLL  GAT
Sbjct: 147 VDEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGAT 206

Query: 170 VDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHL 229
           VD +D LD T + WACRGGHL ++K L + GA  N RDK+ STPLHVAVRT   + +EH 
Sbjct: 207 VDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHF 266

Query: 230 IECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLARDWQRG 289
           +  G  +NA+D+EGDTALH+AVR   YK +KLLLL+GA++  +N A  TP  L + WQ  
Sbjct: 267 LSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLVQLWQAD 326

Query: 290 IREALQ 295
            R AL+
Sbjct: 327 TRHALE 332


>gi|194018403 ankyrin repeat domain 2 isoform b [Homo sapiens]
          Length = 327

 Score =  149 bits (376), Expect = 3e-36
 Identities = 92/246 (37%), Positives = 126/246 (51%), Gaps = 37/246 (15%)

Query: 54  EKKKKLERFNSTRFNLD----NLADLENLVQRRKKRLRHRVPPRKPEPLVKPQSQAQVEP 109
           +K K  ER   T  +L     ++  ++NL++ RKKR + +           P+ +    P
Sbjct: 87  QKVKGQERVRKTSLDLRREIIDVGGIQNLIELRKKRKQKKRDALAASHEPPPEPEEITGP 146

Query: 110 VGLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGAT 169
           V  E FLKAA E +  +I+K+L DGG  +  D+  RTALH A L+GH +++ KLL  GAT
Sbjct: 147 VDEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGAT 206

Query: 170 VDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHL 229
           VD +D LD T + WACRGGHL ++K L + GA  N RDK G T LH AVR          
Sbjct: 207 VDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNR------- 259

Query: 230 IECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLARDWQRG 289
                                     YK +KLLLL+GA++  +N A  TP  L + WQ  
Sbjct: 260 --------------------------YKIIKLLLLHGADMMTKNLAGKTPTDLVQLWQAD 293

Query: 290 IREALQ 295
            R AL+
Sbjct: 294 TRHALE 299


>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
          Length = 919

 Score =  105 bits (262), Expect = 5e-23
 Identities = 57/146 (39%), Positives = 80/146 (54%)

Query: 138 NAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLL 197
           N  D+  RTALH A L GH ++VN LL  GA ++A D  DR  + WA   GHL ++  L+
Sbjct: 109 NVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLI 168

Query: 198 NQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYK 257
           N GA V  +DK G TPLH A      + ++HL+  G  ++  +  G+TALH A  +G   
Sbjct: 169 NHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDA 228

Query: 258 AMKLLLLYGAELGVRNAASVTPVQLA 283
            +  L+ YGA +   N    TP+  A
Sbjct: 229 VVNELIDYGANVNQPNNNGFTPLHFA 254



 Score = 88.6 bits (218), Expect = 6e-18
 Identities = 53/167 (31%), Positives = 86/167 (51%), Gaps = 3/167 (1%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLD 177
           AA      +++  L  G + NA DK  R ALHWA   GH  +V  L+  GA V  +D   
Sbjct: 122 AALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKG 181

Query: 178 RTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLN 237
            TP+  A   G + ++K LLN G  ++  +  G+T LH+A        +  LI+ GA++N
Sbjct: 182 YTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVN 241

Query: 238 AQDKEGDTALH--EAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQL 282
             +  G T LH   A  HG+   ++LL+  GA++ +++    +P+ +
Sbjct: 242 QPNNNGFTPLHFAAASTHGAL-CLELLVNNGADVNIQSKDGKSPLHM 287



 Score = 84.3 bits (207), Expect = 1e-16
 Identities = 49/134 (36%), Positives = 72/134 (53%)

Query: 136 DPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQ 195
           D N  D   RT LH A   G ++++  L+++GA V+A+D +  TP+  A        ++ 
Sbjct: 8   DVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQV 67

Query: 196 LLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGS 255
           L+   A VNARDK   TPLHVA   +   C E +I   + +N  D+ G TALH A  +G 
Sbjct: 68  LIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGH 127

Query: 256 YKAMKLLLLYGAEL 269
            + + LLL  GA +
Sbjct: 128 VEMVNLLLAKGANI 141



 Score = 83.6 bits (205), Expect = 2e-16
 Identities = 51/133 (38%), Positives = 65/133 (48%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLD 177
           AA    E LI+   T G D           LH A L  HS    KLL +G  +D  D   
Sbjct: 321 AARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFG 380

Query: 178 RTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLN 237
           RT +  A  GG++  +K L + GA  + +DK G TPLH A    H  C+E L+  GA++N
Sbjct: 381 RTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVN 440

Query: 238 AQDKEGDTALHEA 250
             D  G TALH A
Sbjct: 441 ETDDWGRTALHYA 453



 Score = 79.0 bits (193), Expect = 5e-15
 Identities = 52/167 (31%), Positives = 77/167 (46%)

Query: 117 KAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLL 176
           +A A   E  +   +    D NA DK  +T LH A      +    ++   ++V+  D  
Sbjct: 55  RAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRG 114

Query: 177 DRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHL 236
            RT +  A   GH+ ++  LL +GA +NA DK     LH A    H D +  LI  GA +
Sbjct: 115 GRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEV 174

Query: 237 NAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
             +DK+G T LH A  +G    +K LL  G E+   N    T + +A
Sbjct: 175 TCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIA 221



 Score = 76.6 bits (187), Expect = 2e-14
 Identities = 47/166 (28%), Positives = 73/166 (43%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLD 177
           AA+ +    ++  + +G D N   K  ++ LH   + G       L+  G  +D  D   
Sbjct: 255 AASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDG 314

Query: 178 RTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLN 237
            TP+  A R GH +++  L   GA           PLH+A    H DC   L+  G  ++
Sbjct: 315 NTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEID 374

Query: 238 AQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
             DK G T LH A   G+ + +KLL   GA+   ++    TP+  A
Sbjct: 375 TPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYA 420



 Score = 72.8 bits (177), Expect = 4e-13
 Identities = 51/170 (30%), Positives = 85/170 (50%), Gaps = 4/170 (2%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARD-LL 176
           AA       ++  L    D +  D+  RTAL  A  KGH++ V  L+  GA++  +D + 
Sbjct: 549 AAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVT 608

Query: 177 DRTPVFWACRGGHLVILKQLL---NQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECG 233
            RTP+  +   GH + L+ LL   +    V+ +D  G TPL +AV   H D +  L+E  
Sbjct: 609 KRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKE 668

Query: 234 AHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
           A+++  D  G TALH  +  G  + +++LL     +  +++   TP+  A
Sbjct: 669 ANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYA 718



 Score = 70.1 bits (170), Expect = 2e-12
 Identities = 42/139 (30%), Positives = 67/139 (48%)

Query: 131 LTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHL 190
           + +GG+ +  DK   T LH A   GH  L+N L  +GA      +    P+  A    H 
Sbjct: 301 IQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHS 360

Query: 191 VILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEA 250
              ++LL+ G  ++  DK G T LH A    + +C++ L   GA  + +DK G T LH A
Sbjct: 361 DCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYA 420

Query: 251 VRHGSYKAMKLLLLYGAEL 269
             +  +  ++ L+  GA +
Sbjct: 421 AANCHFHCIETLVTTGANV 439



 Score = 65.9 bits (159), Expect = 4e-11
 Identities = 46/144 (31%), Positives = 72/144 (50%), Gaps = 6/144 (4%)

Query: 124 EYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFW 183
           E L+++  T+ G   +     ++ LH A   GH Q +  LL +   +D RD   RT +  
Sbjct: 524 ELLLER--TNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDL 581

Query: 184 ACRGGHLVILKQLLNQGARVNARDKIGS-TPLHVAVRTRHPDCLEHLIECGAH---LNAQ 239
           A   GH   ++ L+N GA +  +D +   TPLH +V   H  CL  L+E   +   ++ +
Sbjct: 582 AAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVK 641

Query: 240 DKEGDTALHEAVRHGSYKAMKLLL 263
           D +G T L  AV +G   A+ LLL
Sbjct: 642 DAKGQTPLMLAVAYGHIDAVSLLL 665



 Score = 64.3 bits (155), Expect = 1e-10
 Identities = 37/113 (32%), Positives = 56/113 (49%), Gaps = 3/113 (2%)

Query: 145 RTALHWACLKGHSQLVNKLLVAG---ATVDARDLLDRTPVFWACRGGHLVILKQLLNQGA 201
           RT LH + + GH+  +  LL        VD +D   +TP+  A   GH+  +  LL + A
Sbjct: 610 RTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEA 669

Query: 202 RVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHG 254
            V+  D +G T LH  + T H +C++ L+E    +  +D  G T LH A   G
Sbjct: 670 NVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARG 722



 Score = 62.4 bits (150), Expect = 5e-10
 Identities = 51/181 (28%), Positives = 78/181 (43%), Gaps = 38/181 (20%)

Query: 141 DKLHRTALHWACLKGHSQLVNKLLVAGATVDA---RDLLDRTPVFWACRGGHLVILKQLL 197
           D   RT LH+A  +GH+  +++LL    + +    +D    TP+ WAC  G+   ++ LL
Sbjct: 708 DSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLL 767

Query: 198 NQ----------------------------------GARVNARDKIGSTPLHVAVRTRHP 223
            Q                                   + V+ RD  G TPL  A    H 
Sbjct: 768 EQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHV 827

Query: 224 DCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYG-AELGVRNAASVTPVQL 282
           +CL+ L+   A +NA D  G TAL  A  +G   A+ +L+    A+L V++    TP+ L
Sbjct: 828 ECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHL 887

Query: 283 A 283
           A
Sbjct: 888 A 888



 Score = 58.2 bits (139), Expect = 9e-09
 Identities = 55/199 (27%), Positives = 81/199 (40%), Gaps = 36/199 (18%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLD 177
           AAA      I    + G D +  DK  RT LH+A    H   +  L+  GA V+  D   
Sbjct: 387 AAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWG 446

Query: 178 RTPVFWAC----------------------RGGHL------VILKQLLNQGARVNARDKI 209
           RT + +A                       R   L      + L+ LL   A  + RDK 
Sbjct: 447 RTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKE 506

Query: 210 GSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTA-----LHEAVRHGSYKAMKLLLL 264
           G   +H A    H  CLE L+E     N+  +E D+      LH A  +G ++A+++LL 
Sbjct: 507 GYNSIHYAAAYGHRQCLELLLE---RTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQ 563

Query: 265 YGAELGVRNAASVTPVQLA 283
              +L +R+    T + LA
Sbjct: 564 SLVDLDIRDEKGRTALDLA 582



 Score = 54.3 bits (129), Expect = 1e-07
 Identities = 39/126 (30%), Positives = 56/126 (44%), Gaps = 3/126 (2%)

Query: 141 DKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQG 200
           D   +T L  A   GH   V+ LL   A VD  D+L  T +      GH   ++ LL Q 
Sbjct: 642 DAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQE 701

Query: 201 ARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLN---AQDKEGDTALHEAVRHGSYK 257
             +  +D  G TPLH A    H   L  L++          +D +G T LH A  +G+  
Sbjct: 702 VSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNEN 761

Query: 258 AMKLLL 263
            +++LL
Sbjct: 762 CIEVLL 767



 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 41/121 (33%), Positives = 55/121 (45%), Gaps = 3/121 (2%)

Query: 146 TALHWACLKGHSQLVNKLLVA--GATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARV 203
           T LH A +  H    + LL A   + V  RD   RTP+  A    H+  L+ LL   A V
Sbjct: 781 TPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPV 840

Query: 204 NARDKIGSTPLHVAVRTRHPDCLEHLIECG-AHLNAQDKEGDTALHEAVRHGSYKAMKLL 262
           NA D  G T L +A        ++ L+    A L  +DK+ +T LH A   G  K   L+
Sbjct: 841 NAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLI 900

Query: 263 L 263
           L
Sbjct: 901 L 901



 Score = 52.0 bits (123), Expect = 7e-07
 Identities = 31/88 (35%), Positives = 49/88 (55%)

Query: 196 LLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGS 255
           L+++   VN  D    TPLHVA      + +E LI  GA +NA+D    T LH AV   S
Sbjct: 2   LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRS 61

Query: 256 YKAMKLLLLYGAELGVRNAASVTPVQLA 283
            +A+++L+ + A++  R+    TP+ +A
Sbjct: 62  EEAVQVLIKHSADVNARDKNWQTPLHVA 89



 Score = 51.6 bits (122), Expect = 9e-07
 Identities = 32/94 (34%), Positives = 45/94 (47%), Gaps = 3/94 (3%)

Query: 141 DKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQG 200
           D L  TALH   + GH + V  LL    ++  +D   RTP+ +A   GH   L +LL   
Sbjct: 675 DILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMA 734

Query: 201 ARVNA---RDKIGSTPLHVAVRTRHPDCLEHLIE 231
                   +D  G TPLH A    + +C+E L+E
Sbjct: 735 LSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLE 768



 Score = 48.9 bits (115), Expect = 6e-06
 Identities = 53/194 (27%), Positives = 79/194 (40%), Gaps = 31/194 (15%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWAC--------------------LKGHS 157
           AAA    + I+  +T G + N  D   RTALH+A                     L+   
Sbjct: 420 AAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERAR 479

Query: 158 QLVNK--------LLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKI 209
           +L  K        LL   A    RD      + +A   GH   L+ LL +          
Sbjct: 480 ELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDS 539

Query: 210 GST--PLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGA 267
           G+T  PLH+A    H   LE L++    L+ +D++G TAL  A   G  + ++ L+  GA
Sbjct: 540 GATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGA 599

Query: 268 ELGVR-NAASVTPV 280
            + V+ N    TP+
Sbjct: 600 SIFVKDNVTKRTPL 613



 Score = 38.9 bits (89), Expect = 0.006
 Identities = 28/94 (29%), Positives = 40/94 (42%), Gaps = 1/94 (1%)

Query: 133 DGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVI 192
           D    +  D   RT L  A    H + +  LL   A V+A D   +T +  A   G    
Sbjct: 803 DSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGA 862

Query: 193 LKQLLNQG-ARVNARDKIGSTPLHVAVRTRHPDC 225
           +  L+N   A +  +DK  +TPLH+A    H  C
Sbjct: 863 VDILVNSAQADLTVKDKDLNTPLHLACSKGHEKC 896


>gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo
           sapiens]
          Length = 226

 Score =  102 bits (255), Expect = 3e-22
 Identities = 61/165 (36%), Positives = 89/165 (53%)

Query: 124 EYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFW 183
           E L +  L D       D+  RTALHWAC  GH+++V  LL  G  V+ +D    +P+  
Sbjct: 20  EELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHI 79

Query: 184 ACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEG 243
           A   G   I+K LL +GA+VNA ++ G TPLH A      +    L+E GA+ +A+D   
Sbjct: 80  AASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYE 139

Query: 244 DTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLARDWQR 288
            TA+H A   G+ K + +LL Y A   +++    TP+ LA D +R
Sbjct: 140 ATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEER 184



 Score = 62.8 bits (151), Expect = 4e-10
 Identities = 41/133 (30%), Positives = 66/133 (49%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLD 177
           AA+  ++ ++   L  G   NA ++   T LH+A  K   ++   LL  GA  DA+D  +
Sbjct: 80  AASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYE 139

Query: 178 RTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLN 237
            T +  A   G+L ++  LL   A  N +D  G+TPLH+A      +  + L+  GA + 
Sbjct: 140 ATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIY 199

Query: 238 AQDKEGDTALHEA 250
            ++KE  T L  A
Sbjct: 200 IENKEEKTPLQVA 212



 Score = 31.2 bits (69), Expect = 1.2
 Identities = 27/111 (24%), Positives = 48/111 (43%), Gaps = 4/111 (3%)

Query: 87  RHRVPPRKPEPLVKPQSQAQVEPVGLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRT 146
           RH +     E    P ++   E   +    +AAA+    +I   L      N  D    T
Sbjct: 118 RHEIAVMLLEGGANPDAKDHYEATAMH---RAAAKGNLKMIHILLYYKASTNIQDTEGNT 174

Query: 147 ALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLL 197
            LH AC +   +    L+  GA++   +  ++TP+    +GG  +ILK+++
Sbjct: 175 PLHLACDEERVEEAKLLVSQGASIYIENKEEKTPL-QVAKGGLGLILKRMV 224


>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
          Length = 4377

 Score = 97.4 bits (241), Expect = 1e-20
 Identities = 64/189 (33%), Positives = 95/189 (50%), Gaps = 1/189 (0%)

Query: 96  EPLVKPQSQAQ-VEPVGLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLK 154
           E L+K  +  Q V   GL     AA      ++ + +  G  PN  +    TALH A   
Sbjct: 417 ELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARS 476

Query: 155 GHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPL 214
           G +++V  L+  GA V+A+   D+TP+  + R G   I++QLL QGA  NA    G TPL
Sbjct: 477 GQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPL 536

Query: 215 HVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNA 274
           H++ R  H D    L++ GA L+   K+G T LH A ++G  +   LLL   A       
Sbjct: 537 HLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGK 596

Query: 275 ASVTPVQLA 283
           + +TP+ +A
Sbjct: 597 SGLTPLHVA 605



 Score = 85.5 bits (210), Expect = 5e-17
 Identities = 60/186 (32%), Positives = 90/186 (48%), Gaps = 2/186 (1%)

Query: 116 LKAAAENQEYLIDKYLTDG-GDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARD 174
           L  AA    Y + K L D   +PNA      T LH AC K   +++  LL  GA++ A  
Sbjct: 371 LHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVT 430

Query: 175 LLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGA 234
               TP+  A   GH+ I+ QL++ GA  N  +  G T LH+A R+   + + +L++ GA
Sbjct: 431 ESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGA 490

Query: 235 HLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQL-ARDWQRGIREA 293
            + A+ K+  T LH + R G    ++ LL  GA       +  TP+ L AR+    +   
Sbjct: 491 QVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAF 550

Query: 294 LQAHVA 299
           L  H A
Sbjct: 551 LLDHGA 556



 Score = 84.7 bits (208), Expect = 9e-17
 Identities = 49/166 (29%), Positives = 82/166 (49%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLD 177
           A  +N+  +++  L  G    A  +   T +H A   GH  +V++L+  GA+ +  ++  
Sbjct: 407 ACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRG 466

Query: 178 RTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLN 237
            T +  A R G   +++ L+  GA+V A+ K   TPLH++ R    D ++ L++ GA  N
Sbjct: 467 ETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPN 526

Query: 238 AQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
           A    G T LH + R G       LL +GA L +      TP+ +A
Sbjct: 527 AATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVA 572



 Score = 82.4 bits (202), Expect = 5e-16
 Identities = 51/153 (33%), Positives = 74/153 (48%)

Query: 131 LTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHL 190
           L  G  P+A  K   T LH A  K    +   LL  GA  +A        V  A + GH+
Sbjct: 618 LDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHV 677

Query: 191 VILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEA 250
            ++  LL + A VN  +K G TPLH+A +    +  E L+  GAH++AQ K G T LH  
Sbjct: 678 DMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVG 737

Query: 251 VRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
             +G+ K +  LL + A++  +     TP+  A
Sbjct: 738 CHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQA 770



 Score = 79.7 bits (195), Expect = 3e-15
 Identities = 52/167 (31%), Positives = 83/167 (49%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLD 177
           AA +NQ  +    L  G D NA  +    ++H A  +GH  +V+ LL   A V+  +   
Sbjct: 638 AAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSG 697

Query: 178 RTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLN 237
            TP+  A +   + + + L+NQGA V+A+ K+G TPLHV     +   +  L++  A +N
Sbjct: 698 LTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVN 757

Query: 238 AQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLAR 284
           A+ K G T LH+A + G    + +LL   A          T + +AR
Sbjct: 758 AKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIAR 804



 Score = 78.2 bits (191), Expect = 9e-15
 Identities = 58/184 (31%), Positives = 84/184 (45%), Gaps = 1/184 (0%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLD 177
           +A E  E +    L  G   +   K   T LH A   G  ++ N LL   A+ DA     
Sbjct: 539 SAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSG 598

Query: 178 RTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLN 237
            TP+  A    +  +   LL+QGA  +A  K G TPLH+A +    D    L+E GA  N
Sbjct: 599 LTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADAN 658

Query: 238 AQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLARDWQR-GIREALQA 296
           A  ++G  ++H A + G    + LLL   A + + N + +TP+ LA    R  + E L  
Sbjct: 659 AVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVN 718

Query: 297 HVAH 300
             AH
Sbjct: 719 QGAH 722



 Score = 77.8 bits (190), Expect = 1e-14
 Identities = 45/138 (32%), Positives = 73/138 (52%)

Query: 146 TALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNA 205
           TALH A   GH ++   LL   A  +A+ L   TP+  AC+   + +++ LL  GA + A
Sbjct: 369 TALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQA 428

Query: 206 RDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLY 265
             + G TP+HVA    H + +  L+  GA  N  +  G+TALH A R G  + ++ L+  
Sbjct: 429 VTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQD 488

Query: 266 GAELGVRNAASVTPVQLA 283
           GA++  +     TP+ ++
Sbjct: 489 GAQVEAKAKDDQTPLHIS 506



 Score = 77.0 bits (188), Expect = 2e-14
 Identities = 61/192 (31%), Positives = 100/192 (52%), Gaps = 13/192 (6%)

Query: 74  DLE-NLVQRRKKRLRHRVPPRKPEPLVKPQSQAQVEPVGLEMFLKAA-AENQEYLIDKYL 131
           DLE N  +  +K+ +HR   R      K +S A         +L+AA A + E  +D Y+
Sbjct: 13  DLEINAEEEPEKKRKHRKRSRDR----KKKSDANAS------YLRAARAGHLEKALD-YI 61

Query: 132 TDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLV 191
            +G D N  ++    ALH A  +GH ++V++LL   A VDA      T +  A   G   
Sbjct: 62  KNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAE 121

Query: 192 ILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAV 251
           ++K L+  GA VNA+ + G TPL++A +  H + ++ L++ GA  +   ++G T L  A+
Sbjct: 122 VVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVAL 181

Query: 252 RHGSYKAMKLLL 263
           + G  + + LLL
Sbjct: 182 QQGHDQVVSLLL 193



 Score = 75.9 bits (185), Expect = 4e-14
 Identities = 44/138 (31%), Positives = 74/138 (53%)

Query: 146 TALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNA 205
           T LH A  +G++ +V  LL  GA +DA+     TP+    R GH  +++ LL++ A + +
Sbjct: 270 TPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILS 329

Query: 206 RDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLY 265
           + K G +PLH+A +  H +C++ L++    ++    +  TALH A   G YK  K+LL  
Sbjct: 330 KTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDK 389

Query: 266 GAELGVRNAASVTPVQLA 283
            A    +     TP+ +A
Sbjct: 390 KANPNAKALNGFTPLHIA 407



 Score = 74.3 bits (181), Expect = 1e-13
 Identities = 55/172 (31%), Positives = 81/172 (47%), Gaps = 1/172 (0%)

Query: 113 EMFLKAAAENQEYLIDKYLT-DGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVD 171
           E  L  AA + +  + +YL  DG    A  K  +T LH +   G + +V +LL  GA+ +
Sbjct: 467 ETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPN 526

Query: 172 ARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIE 231
           A      TP+  + R GH  +   LL+ GA ++   K G TPLHVA +    +    L++
Sbjct: 527 AATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQ 586

Query: 232 CGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
             A  +A  K G T LH A  + + K   LLL  GA          TP+ +A
Sbjct: 587 KSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIA 638



 Score = 73.9 bits (180), Expect = 2e-13
 Identities = 54/173 (31%), Positives = 84/173 (48%), Gaps = 4/173 (2%)

Query: 111 GLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATV 170
           GL     A+ E    ++ + L    + +A  K   TALH A L G +++V  L+  GA V
Sbjct: 74  GLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANV 133

Query: 171 DARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLI 230
           +A+     TP++ A +  HL ++K LL+ GA  +   + G TPL VA++  H   +  L+
Sbjct: 134 NAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLL 193

Query: 231 ECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
           E     + + K    ALH A R    KA  LLL       V + +  TP+ +A
Sbjct: 194 E----NDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIA 242



 Score = 70.9 bits (172), Expect = 1e-12
 Identities = 49/158 (31%), Positives = 69/158 (43%)

Query: 126 LIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWAC 185
           ++ + L  G  PNA      T LH +  +GH  +   LL  GA++        TP+  A 
Sbjct: 514 IVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAA 573

Query: 186 RGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDT 245
           + G L +   LL + A  +A  K G TPLHVA    +      L++ GA  +A  K G T
Sbjct: 574 KYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYT 633

Query: 246 ALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
            LH A +         LL YGA+        +  V LA
Sbjct: 634 PLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLA 671



 Score = 67.0 bits (162), Expect = 2e-11
 Identities = 47/151 (31%), Positives = 69/151 (45%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLD 177
           AA E    ++   L    + N  +K   T LH A  +    +   L+  GA VDA+  + 
Sbjct: 671 AAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMG 730

Query: 178 RTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLN 237
            TP+   C  G++ I+  LL   A+VNA+ K G TPLH A +  H   +  L++  A  N
Sbjct: 731 YTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPN 790

Query: 238 AQDKEGDTALHEAVRHGSYKAMKLLLLYGAE 268
                G+TAL  A R G    +  L +   E
Sbjct: 791 ELTVNGNTALGIARRLGYISVVDTLKIVTEE 821



 Score = 65.5 bits (158), Expect = 6e-11
 Identities = 41/133 (30%), Positives = 69/133 (51%)

Query: 131 LTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHL 190
           L +  + +   K   T LH A   G+  +   LL   A VD     D TP+  A + G+ 
Sbjct: 222 LQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNA 281

Query: 191 VILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEA 250
            ++K LL++GA+++A+ + G TPLH   R+ H   +E L++  A + ++ K G + LH A
Sbjct: 282 NMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMA 341

Query: 251 VRHGSYKAMKLLL 263
            +      ++LLL
Sbjct: 342 TQGDHLNCVQLLL 354



 Score = 58.9 bits (141), Expect = 5e-09
 Identities = 36/133 (27%), Positives = 65/133 (48%)

Query: 151 ACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIG 210
           A   GH +     +  G  ++  +      +  A + GH+ ++ +LL + A V+A  K G
Sbjct: 48  AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG 107

Query: 211 STPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELG 270
           +T LH+A      + ++ L+  GA++NAQ + G T L+ A +    + +K LL  GA   
Sbjct: 108 NTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQS 167

Query: 271 VRNAASVTPVQLA 283
           +      TP+ +A
Sbjct: 168 LATEDGFTPLAVA 180



 Score = 58.9 bits (141), Expect = 5e-09
 Identities = 39/142 (27%), Positives = 71/142 (50%)

Query: 142 KLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGA 201
           K+   ALH A  K  ++    LL      D       TP+  A   G++ +   LLN+ A
Sbjct: 200 KVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAA 259

Query: 202 RVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKL 261
            V+   +   TPLHVA +  + + ++ L++ GA ++A+ ++G T LH   R G  + +++
Sbjct: 260 AVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEM 319

Query: 262 LLLYGAELGVRNAASVTPVQLA 283
           LL   A +  +    ++P+ +A
Sbjct: 320 LLDRAAPILSKTKNGLSPLHMA 341



 Score = 58.5 bits (140), Expect = 7e-09
 Identities = 42/152 (27%), Positives = 67/152 (44%)

Query: 131 LTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHL 190
           L     P+A  K   T LH A    + ++   LL  GA+  A      TP+  A +   +
Sbjct: 585 LQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQM 644

Query: 191 VILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEA 250
            I   LL  GA  NA  + G   +H+A +  H D +  L+   A++N  +K G T LH A
Sbjct: 645 DIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLA 704

Query: 251 VRHGSYKAMKLLLLYGAELGVRNAASVTPVQL 282
            +       ++L+  GA +  +     TP+ +
Sbjct: 705 AQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHV 736



 Score = 50.1 bits (118), Expect = 2e-06
 Identities = 35/109 (32%), Positives = 52/109 (47%)

Query: 111 GLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATV 170
           GL     AA E++  + +  +  G   +A  K+  T LH  C  G+ ++VN LL   A V
Sbjct: 697 GLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKV 756

Query: 171 DARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVR 219
           +A+     TP+  A + GH  I+  LL   A  N     G+T L +A R
Sbjct: 757 NAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARR 805


>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
          Length = 1053

 Score = 97.1 bits (240), Expect = 2e-20
 Identities = 51/146 (34%), Positives = 78/146 (53%)

Query: 138 NAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLL 197
           N  D+  RTALH A   GH ++V  LL  GA ++A D  DR  + WA   GH+ ++K L+
Sbjct: 134 NVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLV 193

Query: 198 NQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYK 257
           + GA V  +DK   TPLH A  +     +++L++ G  +N  +  G+T LH A  +G   
Sbjct: 194 SHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDV 253

Query: 258 AMKLLLLYGAELGVRNAASVTPVQLA 283
            +  L+  GA +  +N    TP+  A
Sbjct: 254 VVNELIDCGAIVNQKNEKGFTPLHFA 279



 Score = 95.1 bits (235), Expect = 7e-20
 Identities = 56/167 (33%), Positives = 91/167 (54%), Gaps = 3/167 (1%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLD 177
           AA      ++   L+ G + NA DK  R A+HWA   GH ++V  L+  GA V  +D   
Sbjct: 147 AAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKS 206

Query: 178 RTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLN 237
            TP+  A   G + ++K LL+ G  +N  +  G+TPLHVA        +  LI+CGA +N
Sbjct: 207 YTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVN 266

Query: 238 AQDKEGDTALH--EAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQL 282
            ++++G T LH   A  HG+   ++LL+  GA++ +++    TP+ +
Sbjct: 267 QKNEKGFTPLHFAAASTHGAL-CLELLVGNGADVNMKSKDGKTPLHM 312



 Score = 85.5 bits (210), Expect = 5e-17
 Identities = 58/157 (36%), Positives = 75/157 (47%), Gaps = 1/157 (0%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLD 177
           AA    E LI+  +T G D           LH A L G S    KLL +G  +D  D   
Sbjct: 346 AARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFG 405

Query: 178 RTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLN 237
           RT +  A  GG+L  L  LLN GA  N +DK G +PLH A    +  CL  L+  GA +N
Sbjct: 406 RTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVN 465

Query: 238 AQDKEGDTALHEAVRHGS-YKAMKLLLLYGAELGVRN 273
             D+ G T LH A    +  K ++ LL   A  G+R+
Sbjct: 466 DLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRD 502



 Score = 84.7 bits (208), Expect = 9e-17
 Identities = 50/134 (37%), Positives = 72/134 (53%)

Query: 136 DPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQ 195
           D N  D   RT LH A   G ++++  L+++GA V+A+D    TP+  A        ++ 
Sbjct: 33  DVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQV 92

Query: 196 LLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGS 255
           LL   A VNARDK   TPLH+A   +   C E L+   +++N  D+ G TALH A   G 
Sbjct: 93  LLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGH 152

Query: 256 YKAMKLLLLYGAEL 269
            + +KLLL  GA +
Sbjct: 153 GEMVKLLLSRGANI 166



 Score = 82.0 bits (201), Expect = 6e-16
 Identities = 48/166 (28%), Positives = 77/166 (46%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLD 177
           AA+ +    ++  + +G D N   K  +T LH   L G       ++ +GA +D  D   
Sbjct: 280 AASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNG 339

Query: 178 RTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLN 237
            TP+  A R GH +++  L+  GA    R   G  PLH+A  +   DC   L+  G  ++
Sbjct: 340 NTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDID 399

Query: 238 AQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
             D  G T LH A   G+ + + LLL  GA+   ++    +P+  A
Sbjct: 400 TPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYA 445



 Score = 79.7 bits (195), Expect = 3e-15
 Identities = 52/167 (31%), Positives = 78/167 (46%)

Query: 117 KAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLL 176
           +A A   E  +   L    D NA DK  +T LH A      +    L+   + V+  D  
Sbjct: 80  RAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRA 139

Query: 177 DRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHL 236
            RT +  A   GH  ++K LL++GA +NA DK     +H A    H + ++ L+  GA +
Sbjct: 140 GRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEV 199

Query: 237 NAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
             +DK+  T LH A   G    +K LL  G ++   NA   TP+ +A
Sbjct: 200 TCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVA 246



 Score = 75.1 bits (183), Expect = 7e-14
 Identities = 53/174 (30%), Positives = 80/174 (45%), Gaps = 6/174 (3%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDK-LHRTALHWACLKGHSQLVNKLLVAGA----TVDA 172
           AA +     +D  +  G      D  L RT +H A   GHS+ + +LL+  A     VD 
Sbjct: 590 AAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECL-RLLIGNAEPQNAVDI 648

Query: 173 RDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIEC 232
           +D   +TP+  +   GH   +  LLN+GA V+A+DK G T LH    T H +C++ L++ 
Sbjct: 649 QDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQH 708

Query: 233 GAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLARDW 286
           GA    +D  G T +H +   G    +  LL   A +    A +      A  W
Sbjct: 709 GAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHW 762



 Score = 73.9 bits (180), Expect = 2e-13
 Identities = 46/153 (30%), Positives = 71/153 (46%)

Query: 131 LTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHL 190
           +  G   +  DK   T LH A   GH  L+N L+ +GA    R +    P+  A   G  
Sbjct: 326 IQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFS 385

Query: 191 VILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEA 250
              ++LL+ G  ++  D  G T LH A    + +CL  L+  GA  N +DK G + LH A
Sbjct: 386 DCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYA 445

Query: 251 VRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
             + +Y+ +  L+  GA +   +    TP+  A
Sbjct: 446 AANCNYQCLFALVGSGASVNDLDERGCTPLHYA 478



 Score = 73.2 bits (178), Expect = 3e-13
 Identities = 57/193 (29%), Positives = 83/193 (43%), Gaps = 38/193 (19%)

Query: 131 LTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHL 190
           L  G + +A DK  RTALH   + GH + V+ LL  GA    RD   RTP+  +   GH+
Sbjct: 673 LNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHI 732

Query: 191 VILKQLLNQGARVNAR----DKIGSTPLHVAVRTRHPDCLEHLIE--------------- 231
            +L  LL   A ++A     D  G T LH A    H  C+E L+E               
Sbjct: 733 GVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFSPL 792

Query: 232 ------------------CGAHL-NAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVR 272
                              GA + NA D +G T LH A      + ++LLL + A++   
Sbjct: 793 HCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSV 852

Query: 273 NAASVTPVQLARD 285
           ++   TP+ +A +
Sbjct: 853 DSTGKTPLMMAAE 865



 Score = 72.4 bits (176), Expect = 5e-13
 Identities = 50/173 (28%), Positives = 78/173 (45%), Gaps = 37/173 (21%)

Query: 148 LHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARD 207
           LH A   GH Q +  L+ +   +D R+   RTP+  A   GH+  +  L+NQGA +  +D
Sbjct: 554 LHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKD 613

Query: 208 KI-------------------------------------GSTPLHVAVRTRHPDCLEHLI 230
            I                                     G TPL ++V   H DC+  L+
Sbjct: 614 YILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLL 673

Query: 231 ECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
             GA+++A+DK G TALH     G  + +  LL +GA+  +R++   TP+ L+
Sbjct: 674 NKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLS 726



 Score = 70.9 bits (172), Expect = 1e-12
 Identities = 58/206 (28%), Positives = 86/206 (41%), Gaps = 39/206 (18%)

Query: 117 KAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDAR--- 173
           + A    E  +D  L  G      D   RT +H +   GH  ++  LL + A++DA    
Sbjct: 692 RGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPAT 751

Query: 174 -DLLDRTPVFWACRGGHLVILKQLL-----------------------NQGAR------- 202
            D    T + WAC  GH   ++ LL                       N+GA        
Sbjct: 752 ADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTL 811

Query: 203 ----VNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKA 258
               VNA D  G TPLH A  T H +CL+ L+   A +N+ D  G T L  A  +G    
Sbjct: 812 GASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNT 871

Query: 259 MKLLL-LYGAELGVRNAASVTPVQLA 283
           +++L+    AEL +++ +  T + LA
Sbjct: 872 VEMLVSSASAELTLQDNSKNTALHLA 897



 Score = 67.8 bits (164), Expect = 1e-11
 Identities = 51/156 (32%), Positives = 72/156 (46%), Gaps = 8/156 (5%)

Query: 116 LKAAAENQEYLIDKYLTDGGDP----NAHDKLHRTALHWACLKGHSQLVNKLLVAGATVD 171
           + AAA N      + L    +P    +  D   +T L  + L GH+  V  LL  GA VD
Sbjct: 621 IHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVD 680

Query: 172 ARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIE 231
           A+D   RT +      GH   +  LL  GA+   RD  G TP+H++    H   L  L++
Sbjct: 681 AKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQ 740

Query: 232 CGAHLNAQ----DKEGDTALHEAVRHGSYKAMKLLL 263
             A ++A     D  G TALH A  +G    ++LLL
Sbjct: 741 SAASMDANPATADNHGYTALHWACYNGHETCVELLL 776



 Score = 65.1 bits (157), Expect = 7e-11
 Identities = 54/186 (29%), Positives = 75/186 (40%), Gaps = 38/186 (20%)

Query: 136 DPNAHDKLHRTALHWACLKGHSQLVNKLL------------------------------- 164
           +P   D    TALHWAC  GH   V  LL                               
Sbjct: 748 NPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEML 807

Query: 165 ---VAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTR 221
              +  + V+A D   RTP+  A    H+  L+ LL+  A+VN+ D  G TPL +A    
Sbjct: 808 IDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENG 867

Query: 222 HPDCLEHLIE-CGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAE---LGVRNAASV 277
             + +E L+    A L  QD   +TALH A   G   +  L+L    +   +   NAA  
Sbjct: 868 QTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQ 927

Query: 278 TPVQLA 283
           TP+ +A
Sbjct: 928 TPLHVA 933



 Score = 60.1 bits (144), Expect = 2e-09
 Identities = 42/133 (31%), Positives = 66/133 (49%)

Query: 151 ACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIG 210
           A   G    V  L+     V+ +D   RTP+  A   G   I++ L+  GARVNA+D   
Sbjct: 15  AIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKW 74

Query: 211 STPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELG 270
            TPLH AV +   + ++ L++  A +NA+DK   T LH A  + + K  + L+   + + 
Sbjct: 75  LTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVN 134

Query: 271 VRNAASVTPVQLA 283
           V + A  T +  A
Sbjct: 135 VSDRAGRTALHHA 147



 Score = 52.8 bits (125), Expect = 4e-07
 Identities = 35/109 (32%), Positives = 57/109 (52%)

Query: 175 LLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGA 234
           L D+  +  A   G    ++ L+ +   VN +D    TPLH A      + +E LI  GA
Sbjct: 6   LRDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGA 65

Query: 235 HLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
            +NA+D +  T LH AV   S +A+++LL + A++  R+    TP+ +A
Sbjct: 66  RVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIA 114



 Score = 49.7 bits (117), Expect = 3e-06
 Identities = 41/146 (28%), Positives = 64/146 (43%), Gaps = 4/146 (2%)

Query: 138 NAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLL 197
           NA D   RT LH A    H + +  LL   A V++ D   +TP+  A   G    ++ L+
Sbjct: 817 NATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLV 876

Query: 198 NQG-ARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAH---LNAQDKEGDTALHEAVRH 253
           +   A +  +D   +T LH+A    H      ++E       +NA +    T LH A R+
Sbjct: 877 SSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARN 936

Query: 254 GSYKAMKLLLLYGAELGVRNAASVTP 279
           G    ++ LL  GA +   +    TP
Sbjct: 937 GLTMVVQELLGKGASVLAVDENGYTP 962



 Score = 48.9 bits (115), Expect = 6e-06
 Identities = 37/125 (29%), Positives = 59/125 (47%), Gaps = 5/125 (4%)

Query: 107 VEPVGLEMFLKAAAENQEYLIDKYLTDGG-DPNAHDKLHRTALHWACLKGHSQ---LVNK 162
           V+  G    + AA   Q   ++  ++    +    D    TALH AC KGH     L+ +
Sbjct: 852 VDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILE 911

Query: 163 LLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTP-LHVAVRTR 221
            +     ++A +   +TP+  A R G  +++++LL +GA V A D+ G TP L  A    
Sbjct: 912 KITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNKD 971

Query: 222 HPDCL 226
             DCL
Sbjct: 972 VADCL 976



 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 39/160 (24%), Positives = 73/160 (45%), Gaps = 15/160 (9%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDA----- 172
           A ++     ++  L +  +P   DK    A+H++   GH +L  +L+ +   +D      
Sbjct: 479 ATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGH-RLCLQLIASETPLDVLMETS 537

Query: 173 -RDLLDRT-------PVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPD 224
             D+L  +       P+  A   GH   L+ L+     ++ R+  G TPL +A    H +
Sbjct: 538 GTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVE 597

Query: 225 CLEHLIECGAHLNAQDK-EGDTALHEAVRHGSYKAMKLLL 263
           C++ LI  GA +  +D     T +H A  +G  + ++LL+
Sbjct: 598 CVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLI 637



 Score = 43.9 bits (102), Expect = 2e-04
 Identities = 36/120 (30%), Positives = 57/120 (47%), Gaps = 6/120 (5%)

Query: 131 LTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLV-AGATVDARDLLDRTPVFWACRGGH 189
           L+     N+ D   +T L  A   G +  V  L+  A A +  +D    T +  AC  GH
Sbjct: 843 LSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGH 902

Query: 190 ----LVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDT 245
               L+IL+++ ++   +NA +    TPLHVA R      ++ L+  GA + A D+ G T
Sbjct: 903 ETSALLILEKITDRNL-INATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYT 961


>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
          Length = 1897

 Score = 96.3 bits (238), Expect = 3e-20
 Identities = 65/185 (35%), Positives = 95/185 (51%), Gaps = 3/185 (1%)

Query: 102 QSQAQVEPVGLEMF--LKAAAENQEYLIDKYLTD-GGDPNAHDKLHRTALHWACLKGHSQ 158
           Q  A+++ + L+    L  AA    + + K L D G  PN+      T LH AC K H +
Sbjct: 359 QYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVR 418

Query: 159 LVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAV 218
           ++  LL  GA++DA      TP+  A   GHL I+K LL +GA  N  +    TPLH+A 
Sbjct: 419 VMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAA 478

Query: 219 RTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVT 278
           R  H +  ++L++  A +NA+ K+  T LH A R G    +KLLL   A   +   A  T
Sbjct: 479 RAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHT 538

Query: 279 PVQLA 283
           P+ +A
Sbjct: 539 PLHIA 543



 Score = 89.0 bits (219), Expect = 5e-18
 Identities = 67/215 (31%), Positives = 97/215 (45%), Gaps = 4/215 (1%)

Query: 88  HRVPPRKPEPLVKPQSQAQVEPVGLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTA 147
           HRV     +   KP S+A      L +   A  +N   +++  L  G   +A  +   T 
Sbjct: 384 HRVAKVLLDKGAKPNSRALNGFTPLHI---ACKKNHVRVMELLLKTGASIDAVTESGLTP 440

Query: 148 LHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARD 207
           LH A   GH  +V  LL  GA+ +  ++   TP+  A R GH  + K LL   A+VNA+ 
Sbjct: 441 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 500

Query: 208 KIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGA 267
           K   TPLH A R  H + ++ L+E  A+ N     G T LH A R G  + +  LL   A
Sbjct: 501 KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA 560

Query: 268 ELGVRNAASVTPVQLARDWQR-GIREALQAHVAHP 301
                     TP+ +A  + +  + E L    AHP
Sbjct: 561 SQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP 595



 Score = 85.1 bits (209), Expect = 7e-17
 Identities = 52/158 (32%), Positives = 76/158 (48%)

Query: 126 LIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWAC 185
           ++   L  G  PN  +    T LH A   GH+++   LL   A V+A+   D+TP+  A 
Sbjct: 452 IVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAA 511

Query: 186 RGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDT 245
           R GH  ++K LL   A  N     G TPLH+A R  H + +  L+E  A      K+G T
Sbjct: 512 RIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFT 571

Query: 246 ALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
            LH A ++G  +  +LLL   A         +TP+ +A
Sbjct: 572 PLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVA 609



 Score = 83.6 bits (205), Expect = 2e-16
 Identities = 60/169 (35%), Positives = 81/169 (47%), Gaps = 1/169 (0%)

Query: 116 LKAAAENQEYLIDKYLTDGGDP-NAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARD 174
           L  AA N    I + L D G P  A  K   + +H A    H   V  LL   A +D   
Sbjct: 309 LHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDIT 368

Query: 175 LLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGA 234
           L   TP+  A   GH  + K LL++GA+ N+R   G TPLH+A +  H   +E L++ GA
Sbjct: 369 LDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGA 428

Query: 235 HLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
            ++A  + G T LH A   G    +K LL  GA   V N    TP+ +A
Sbjct: 429 SIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA 477



 Score = 80.9 bits (198), Expect = 1e-15
 Identities = 52/167 (31%), Positives = 84/167 (50%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLD 177
           AA +NQ  +    L  GG  NA      T LH A  +GH+++V  LL   A  +  +   
Sbjct: 642 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 701

Query: 178 RTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLN 237
            TP+    + GH+ +   L+  G  V+A  ++G TPLHVA    +   ++ L++  A +N
Sbjct: 702 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 761

Query: 238 AQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLAR 284
           A+ K G + LH+A + G    + LLL  GA     ++   TP+ +A+
Sbjct: 762 AKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAK 808



 Score = 79.0 bits (193), Expect = 5e-15
 Identities = 66/192 (34%), Positives = 83/192 (43%), Gaps = 5/192 (2%)

Query: 97  PLVKPQSQAQVEP----VGLEMFLKAAAENQEYLIDKYLTDG-GDPNAHDKLHRTALHWA 151
           P+VK   Q    P    V +E  L  AA      + KYL       NA  K  +T LH A
Sbjct: 451 PIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCA 510

Query: 152 CLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGS 211
              GH+ +V  LL   A  +       TP+  A R GH+  +  LL + A      K G 
Sbjct: 511 ARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGF 570

Query: 212 TPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGV 271
           TPLHVA +       E L+E  AH NA  K G T LH AV H +   +KLLL  G     
Sbjct: 571 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 630

Query: 272 RNAASVTPVQLA 283
                 TP+ +A
Sbjct: 631 PAWNGYTPLHIA 642



 Score = 77.8 bits (190), Expect = 1e-14
 Identities = 46/138 (33%), Positives = 75/138 (54%)

Query: 146 TALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNA 205
           T LH A  +G+  +V  LL  GA ++ +   + TP+  A R GH+ I + LL+ GA + A
Sbjct: 274 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 333

Query: 206 RDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLY 265
           + K G +P+H+A +  H DC+  L++  A ++    +  T LH A   G ++  K+LL  
Sbjct: 334 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 393

Query: 266 GAELGVRNAASVTPVQLA 283
           GA+   R     TP+ +A
Sbjct: 394 GAKPNSRALNGFTPLHIA 411



 Score = 75.1 bits (183), Expect = 7e-14
 Identities = 49/173 (28%), Positives = 82/173 (47%)

Query: 111 GLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATV 170
           GL     A   N   ++   L  GG P++      T LH A  +   ++   LL  G + 
Sbjct: 602 GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA 661

Query: 171 DARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLI 230
           +A  +   TP+  A + GH  ++  LL++ A  N  +K G TPLH+  +  H    + LI
Sbjct: 662 NAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLI 721

Query: 231 ECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
           + G  ++A  + G T LH A  +G+ K +K LL + A++  +     +P+  A
Sbjct: 722 KHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQA 774



 Score = 73.2 bits (178), Expect = 3e-13
 Identities = 48/146 (32%), Positives = 73/146 (50%), Gaps = 4/146 (2%)

Query: 142 KLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGA 201
           K   TALH A L G  ++V +L+  GA V+A+     TP++ A +  HL ++K LL  GA
Sbjct: 109 KKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGA 168

Query: 202 RVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKL 261
             N   + G TPL VA++  H + + HLI  G     + K    ALH A R+   +   +
Sbjct: 169 NQNVATEDGFTPLAVALQQGHENVVAHLINYGT----KGKVRLPALHIAARNDDTRTAAV 224

Query: 262 LLLYGAELGVRNAASVTPVQLARDWQ 287
           LL       V +    TP+ +A  ++
Sbjct: 225 LLQNDPNPDVLSKTGFTPLHIAAHYE 250



 Score = 72.4 bits (176), Expect = 5e-13
 Identities = 49/159 (30%), Positives = 85/159 (53%), Gaps = 2/159 (1%)

Query: 115 FLKAAAE-NQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDAR 173
           FL+AA   N +  +D +L +G D N  ++     LH A  +GH ++V +LL     ++  
Sbjct: 49  FLRAARSGNLDKALD-HLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETT 107

Query: 174 DLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECG 233
                T +  A   G   ++++L+N GA VNA+ + G TPL++A +  H + ++ L+E G
Sbjct: 108 TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENG 167

Query: 234 AHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVR 272
           A+ N   ++G T L  A++ G    +  L+ YG +  VR
Sbjct: 168 ANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR 206



 Score = 72.4 bits (176), Expect = 5e-13
 Identities = 47/153 (30%), Positives = 79/153 (51%)

Query: 131 LTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHL 190
           L +  +P+   K   T LH A    +  +   LL  GA+V+       TP+  A R G++
Sbjct: 226 LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNV 285

Query: 191 VILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEA 250
           ++++ LL++GA++  + K   TPLH A R  H    E L++ GA + A+ K G + +H A
Sbjct: 286 IMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 345

Query: 251 VRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
            +      ++LLL Y AE+       +TP+ +A
Sbjct: 346 AQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVA 378



 Score = 72.0 bits (175), Expect = 6e-13
 Identities = 50/166 (30%), Positives = 74/166 (44%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLD 177
           AA      ++   L +  +PN       T LH A  +GH + V  LL   A+        
Sbjct: 510 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 569

Query: 178 RTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLN 237
            TP+  A + G + + + LL + A  NA  K G TPLHVAV   + D ++ L+  G   +
Sbjct: 570 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 629

Query: 238 AQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
           +    G T LH A +    +  + LL YG      +   VTP+ LA
Sbjct: 630 SPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLA 675



 Score = 70.9 bits (172), Expect = 1e-12
 Identities = 48/166 (28%), Positives = 75/166 (45%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLD 177
           A+      ++   L  G       K   T LH A   GH ++   LL  GA + A+    
Sbjct: 279 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 338

Query: 178 RTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLN 237
            +P+  A +G HL  ++ LL   A ++       TPLHVA    H    + L++ GA  N
Sbjct: 339 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 398

Query: 238 AQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
           ++   G T LH A +    + M+LLL  GA +     + +TP+ +A
Sbjct: 399 SRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVA 444



 Score = 70.1 bits (170), Expect = 2e-12
 Identities = 45/137 (32%), Positives = 68/137 (49%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLD 177
           AA E    ++   L+   + N  +K   T LH    +GH  + + L+  G  VDA   + 
Sbjct: 675 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 734

Query: 178 RTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLN 237
            TP+  A   G++ ++K LL   A VNA+ K+G +PLH A +  H D +  L++ GA  N
Sbjct: 735 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 794

Query: 238 AQDKEGDTALHEAVRHG 254
               +G T L  A R G
Sbjct: 795 EVSSDGTTPLAIAKRLG 811



 Score = 65.5 bits (158), Expect = 6e-11
 Identities = 58/214 (27%), Positives = 96/214 (44%), Gaps = 34/214 (15%)

Query: 99  VKPQSQAQVEPVGLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQ 158
           V  QSQ    P+ +     AA EN   ++   L +G + N   +   T L  A  +GH  
Sbjct: 137 VNAQSQKGFTPLYM-----AAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHEN 191

Query: 159 LVNKLL--------------VAGATVDAR------------DLLDRT---PVFWACRGGH 189
           +V  L+              +A    D R            D+L +T   P+  A    +
Sbjct: 192 VVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYEN 251

Query: 190 LVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHE 249
           L + + LLN+GA VN   + G TPLH+A R  +   +  L++ GA +  + K+  T LH 
Sbjct: 252 LNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHC 311

Query: 250 AVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
           A R+G  +  ++LL +GA +  +    ++P+ +A
Sbjct: 312 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 345



 Score = 65.1 bits (157), Expect = 7e-11
 Identities = 50/186 (26%), Positives = 77/186 (41%)

Query: 98  LVKPQSQAQVEPVGLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHS 157
           L K  SQA +   G      AA   +  + +  L     PNA  K   T LH A    + 
Sbjct: 556 LEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNL 615

Query: 158 QLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVA 217
            +V  LL  G +  +      TP+  A +   + + + LL  G   NA    G TPLH+A
Sbjct: 616 DIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLA 675

Query: 218 VRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASV 277
            +  H + +  L+   A+ N  +K G T LH   + G      +L+ +G  +        
Sbjct: 676 AQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGY 735

Query: 278 TPVQLA 283
           TP+ +A
Sbjct: 736 TPLHVA 741



 Score = 56.2 bits (134), Expect = 3e-08
 Identities = 36/121 (29%), Positives = 64/121 (52%), Gaps = 3/121 (2%)

Query: 184 ACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEG 243
           A + GH+ ++ +LL++   +    K G+T LH+A      + +  L+  GA++NAQ ++G
Sbjct: 85  ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 144

Query: 244 DTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLARDWQRGIREALQAHVAHPRT 303
            T L+ A +    + +K LL  GA   V      TP+ +A   Q+G  E + AH+ +  T
Sbjct: 145 FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA--LQQG-HENVVAHLINYGT 201

Query: 304 R 304
           +
Sbjct: 202 K 202



 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 29/100 (29%), Positives = 48/100 (48%)

Query: 184 ACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEG 243
           A R G+L      L  G  +N  ++ G   LH+A +  H   +  L+     L    K+G
Sbjct: 52  AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 111

Query: 244 DTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
           +TALH A   G  + ++ L+ YGA +  ++    TP+ +A
Sbjct: 112 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMA 151



 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 36/109 (33%), Positives = 51/109 (46%)

Query: 111 GLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATV 170
           GL      A E    + D  +  G   +A  ++  T LH A   G+ +LV  LL   A V
Sbjct: 701 GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADV 760

Query: 171 DARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVR 219
           +A+  L  +P+  A + GH  I+  LL  GA  N     G+TPL +A R
Sbjct: 761 NAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKR 809



 Score = 34.3 bits (77), Expect = 0.14
 Identities = 27/86 (31%), Positives = 42/86 (48%), Gaps = 3/86 (3%)

Query: 126 LIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWAC 185
           L+   L    D NA  KL  + LH A  +GH+ +V  LL  GA+ +       TP+  A 
Sbjct: 749 LVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAK 808

Query: 186 RGGHLV---ILKQLLNQGARVNARDK 208
           R G++    +LK + ++ + V   DK
Sbjct: 809 RLGYISVTDVLKVVTDETSFVLVSDK 834


>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
          Length = 1881

 Score = 96.3 bits (238), Expect = 3e-20
 Identities = 65/185 (35%), Positives = 95/185 (51%), Gaps = 3/185 (1%)

Query: 102 QSQAQVEPVGLEMF--LKAAAENQEYLIDKYLTD-GGDPNAHDKLHRTALHWACLKGHSQ 158
           Q  A+++ + L+    L  AA    + + K L D G  PN+      T LH AC K H +
Sbjct: 326 QYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVR 385

Query: 159 LVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAV 218
           ++  LL  GA++DA      TP+  A   GHL I+K LL +GA  N  +    TPLH+A 
Sbjct: 386 VMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAA 445

Query: 219 RTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVT 278
           R  H +  ++L++  A +NA+ K+  T LH A R G    +KLLL   A   +   A  T
Sbjct: 446 RAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHT 505

Query: 279 PVQLA 283
           P+ +A
Sbjct: 506 PLHIA 510



 Score = 89.0 bits (219), Expect = 5e-18
 Identities = 67/215 (31%), Positives = 97/215 (45%), Gaps = 4/215 (1%)

Query: 88  HRVPPRKPEPLVKPQSQAQVEPVGLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTA 147
           HRV     +   KP S+A      L +   A  +N   +++  L  G   +A  +   T 
Sbjct: 351 HRVAKVLLDKGAKPNSRALNGFTPLHI---ACKKNHVRVMELLLKTGASIDAVTESGLTP 407

Query: 148 LHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARD 207
           LH A   GH  +V  LL  GA+ +  ++   TP+  A R GH  + K LL   A+VNA+ 
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467

Query: 208 KIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGA 267
           K   TPLH A R  H + ++ L+E  A+ N     G T LH A R G  + +  LL   A
Sbjct: 468 KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA 527

Query: 268 ELGVRNAASVTPVQLARDWQR-GIREALQAHVAHP 301
                     TP+ +A  + +  + E L    AHP
Sbjct: 528 SQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP 562



 Score = 85.1 bits (209), Expect = 7e-17
 Identities = 52/158 (32%), Positives = 76/158 (48%)

Query: 126 LIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWAC 185
           ++   L  G  PN  +    T LH A   GH+++   LL   A V+A+   D+TP+  A 
Sbjct: 419 IVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAA 478

Query: 186 RGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDT 245
           R GH  ++K LL   A  N     G TPLH+A R  H + +  L+E  A      K+G T
Sbjct: 479 RIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFT 538

Query: 246 ALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
            LH A ++G  +  +LLL   A         +TP+ +A
Sbjct: 539 PLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVA 576



 Score = 83.6 bits (205), Expect = 2e-16
 Identities = 60/169 (35%), Positives = 81/169 (47%), Gaps = 1/169 (0%)

Query: 116 LKAAAENQEYLIDKYLTDGGDP-NAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARD 174
           L  AA N    I + L D G P  A  K   + +H A    H   V  LL   A +D   
Sbjct: 276 LHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDIT 335

Query: 175 LLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGA 234
           L   TP+  A   GH  + K LL++GA+ N+R   G TPLH+A +  H   +E L++ GA
Sbjct: 336 LDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGA 395

Query: 235 HLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
            ++A  + G T LH A   G    +K LL  GA   V N    TP+ +A
Sbjct: 396 SIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA 444



 Score = 80.9 bits (198), Expect = 1e-15
 Identities = 52/167 (31%), Positives = 84/167 (50%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLD 177
           AA +NQ  +    L  GG  NA      T LH A  +GH+++V  LL   A  +  +   
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 668

Query: 178 RTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLN 237
            TP+    + GH+ +   L+  G  V+A  ++G TPLHVA    +   ++ L++  A +N
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 728

Query: 238 AQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLAR 284
           A+ K G + LH+A + G    + LLL  GA     ++   TP+ +A+
Sbjct: 729 AKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAK 775



 Score = 79.0 bits (193), Expect = 5e-15
 Identities = 66/192 (34%), Positives = 83/192 (43%), Gaps = 5/192 (2%)

Query: 97  PLVKPQSQAQVEP----VGLEMFLKAAAENQEYLIDKYLTDG-GDPNAHDKLHRTALHWA 151
           P+VK   Q    P    V +E  L  AA      + KYL       NA  K  +T LH A
Sbjct: 418 PIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCA 477

Query: 152 CLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGS 211
              GH+ +V  LL   A  +       TP+  A R GH+  +  LL + A      K G 
Sbjct: 478 ARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGF 537

Query: 212 TPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGV 271
           TPLHVA +       E L+E  AH NA  K G T LH AV H +   +KLLL  G     
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597

Query: 272 RNAASVTPVQLA 283
                 TP+ +A
Sbjct: 598 PAWNGYTPLHIA 609



 Score = 77.8 bits (190), Expect = 1e-14
 Identities = 46/138 (33%), Positives = 75/138 (54%)

Query: 146 TALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNA 205
           T LH A  +G+  +V  LL  GA ++ +   + TP+  A R GH+ I + LL+ GA + A
Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300

Query: 206 RDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLY 265
           + K G +P+H+A +  H DC+  L++  A ++    +  T LH A   G ++  K+LL  
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360

Query: 266 GAELGVRNAASVTPVQLA 283
           GA+   R     TP+ +A
Sbjct: 361 GAKPNSRALNGFTPLHIA 378



 Score = 75.1 bits (183), Expect = 7e-14
 Identities = 49/173 (28%), Positives = 82/173 (47%)

Query: 111 GLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATV 170
           GL     A   N   ++   L  GG P++      T LH A  +   ++   LL  G + 
Sbjct: 569 GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA 628

Query: 171 DARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLI 230
           +A  +   TP+  A + GH  ++  LL++ A  N  +K G TPLH+  +  H    + LI
Sbjct: 629 NAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLI 688

Query: 231 ECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
           + G  ++A  + G T LH A  +G+ K +K LL + A++  +     +P+  A
Sbjct: 689 KHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQA 741



 Score = 73.2 bits (178), Expect = 3e-13
 Identities = 48/146 (32%), Positives = 73/146 (50%), Gaps = 4/146 (2%)

Query: 142 KLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGA 201
           K   TALH A L G  ++V +L+  GA V+A+     TP++ A +  HL ++K LL  GA
Sbjct: 76  KKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGA 135

Query: 202 RVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKL 261
             N   + G TPL VA++  H + + HLI  G     + K    ALH A R+   +   +
Sbjct: 136 NQNVATEDGFTPLAVALQQGHENVVAHLINYGT----KGKVRLPALHIAARNDDTRTAAV 191

Query: 262 LLLYGAELGVRNAASVTPVQLARDWQ 287
           LL       V +    TP+ +A  ++
Sbjct: 192 LLQNDPNPDVLSKTGFTPLHIAAHYE 217



 Score = 72.4 bits (176), Expect = 5e-13
 Identities = 49/159 (30%), Positives = 85/159 (53%), Gaps = 2/159 (1%)

Query: 115 FLKAAAE-NQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDAR 173
           FL+AA   N +  +D +L +G D N  ++     LH A  +GH ++V +LL     ++  
Sbjct: 16  FLRAARSGNLDKALD-HLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETT 74

Query: 174 DLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECG 233
                T +  A   G   ++++L+N GA VNA+ + G TPL++A +  H + ++ L+E G
Sbjct: 75  TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENG 134

Query: 234 AHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVR 272
           A+ N   ++G T L  A++ G    +  L+ YG +  VR
Sbjct: 135 ANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR 173



 Score = 72.4 bits (176), Expect = 5e-13
 Identities = 47/153 (30%), Positives = 79/153 (51%)

Query: 131 LTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHL 190
           L +  +P+   K   T LH A    +  +   LL  GA+V+       TP+  A R G++
Sbjct: 193 LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNV 252

Query: 191 VILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEA 250
           ++++ LL++GA++  + K   TPLH A R  H    E L++ GA + A+ K G + +H A
Sbjct: 253 IMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 312

Query: 251 VRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
            +      ++LLL Y AE+       +TP+ +A
Sbjct: 313 AQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVA 345



 Score = 72.0 bits (175), Expect = 6e-13
 Identities = 50/166 (30%), Positives = 74/166 (44%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLD 177
           AA      ++   L +  +PN       T LH A  +GH + V  LL   A+        
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536

Query: 178 RTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLN 237
            TP+  A + G + + + LL + A  NA  K G TPLHVAV   + D ++ L+  G   +
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596

Query: 238 AQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
           +    G T LH A +    +  + LL YG      +   VTP+ LA
Sbjct: 597 SPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLA 642



 Score = 70.9 bits (172), Expect = 1e-12
 Identities = 48/166 (28%), Positives = 75/166 (45%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLD 177
           A+      ++   L  G       K   T LH A   GH ++   LL  GA + A+    
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305

Query: 178 RTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLN 237
            +P+  A +G HL  ++ LL   A ++       TPLHVA    H    + L++ GA  N
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365

Query: 238 AQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
           ++   G T LH A +    + M+LLL  GA +     + +TP+ +A
Sbjct: 366 SRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVA 411



 Score = 70.1 bits (170), Expect = 2e-12
 Identities = 45/137 (32%), Positives = 68/137 (49%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLD 177
           AA E    ++   L+   + N  +K   T LH    +GH  + + L+  G  VDA   + 
Sbjct: 642 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 701

Query: 178 RTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLN 237
            TP+  A   G++ ++K LL   A VNA+ K+G +PLH A +  H D +  L++ GA  N
Sbjct: 702 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761

Query: 238 AQDKEGDTALHEAVRHG 254
               +G T L  A R G
Sbjct: 762 EVSSDGTTPLAIAKRLG 778



 Score = 65.5 bits (158), Expect = 6e-11
 Identities = 58/214 (27%), Positives = 96/214 (44%), Gaps = 34/214 (15%)

Query: 99  VKPQSQAQVEPVGLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQ 158
           V  QSQ    P+ +     AA EN   ++   L +G + N   +   T L  A  +GH  
Sbjct: 104 VNAQSQKGFTPLYM-----AAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHEN 158

Query: 159 LVNKLL--------------VAGATVDAR------------DLLDRT---PVFWACRGGH 189
           +V  L+              +A    D R            D+L +T   P+  A    +
Sbjct: 159 VVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYEN 218

Query: 190 LVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHE 249
           L + + LLN+GA VN   + G TPLH+A R  +   +  L++ GA +  + K+  T LH 
Sbjct: 219 LNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHC 278

Query: 250 AVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
           A R+G  +  ++LL +GA +  +    ++P+ +A
Sbjct: 279 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 312



 Score = 65.1 bits (157), Expect = 7e-11
 Identities = 50/186 (26%), Positives = 77/186 (41%)

Query: 98  LVKPQSQAQVEPVGLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHS 157
           L K  SQA +   G      AA   +  + +  L     PNA  K   T LH A    + 
Sbjct: 523 LEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNL 582

Query: 158 QLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVA 217
            +V  LL  G +  +      TP+  A +   + + + LL  G   NA    G TPLH+A
Sbjct: 583 DIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLA 642

Query: 218 VRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASV 277
            +  H + +  L+   A+ N  +K G T LH   + G      +L+ +G  +        
Sbjct: 643 AQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGY 702

Query: 278 TPVQLA 283
           TP+ +A
Sbjct: 703 TPLHVA 708



 Score = 56.2 bits (134), Expect = 3e-08
 Identities = 36/121 (29%), Positives = 64/121 (52%), Gaps = 3/121 (2%)

Query: 184 ACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEG 243
           A + GH+ ++ +LL++   +    K G+T LH+A      + +  L+  GA++NAQ ++G
Sbjct: 52  ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 111

Query: 244 DTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLARDWQRGIREALQAHVAHPRT 303
            T L+ A +    + +K LL  GA   V      TP+ +A   Q+G  E + AH+ +  T
Sbjct: 112 FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA--LQQG-HENVVAHLINYGT 168

Query: 304 R 304
           +
Sbjct: 169 K 169



 Score = 47.8 bits (112), Expect = 1e-05
 Identities = 32/115 (27%), Positives = 53/115 (46%)

Query: 169 TVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEH 228
           +V  R+    T    A R G+L      L  G  +N  ++ G   LH+A +  H   +  
Sbjct: 4   SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63

Query: 229 LIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
           L+     L    K+G+TALH A   G  + ++ L+ YGA +  ++    TP+ +A
Sbjct: 64  LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMA 118



 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 36/109 (33%), Positives = 51/109 (46%)

Query: 111 GLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATV 170
           GL      A E    + D  +  G   +A  ++  T LH A   G+ +LV  LL   A V
Sbjct: 668 GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADV 727

Query: 171 DARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVR 219
           +A+  L  +P+  A + GH  I+  LL  GA  N     G+TPL +A R
Sbjct: 728 NAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKR 776



 Score = 34.3 bits (77), Expect = 0.14
 Identities = 27/86 (31%), Positives = 42/86 (48%), Gaps = 3/86 (3%)

Query: 126 LIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWAC 185
           L+   L    D NA  KL  + LH A  +GH+ +V  LL  GA+ +       TP+  A 
Sbjct: 716 LVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAK 775

Query: 186 RGGHLV---ILKQLLNQGARVNARDK 208
           R G++    +LK + ++ + V   DK
Sbjct: 776 RLGYISVTDVLKVVTDETSFVLVSDK 801


>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
          Length = 1880

 Score = 96.3 bits (238), Expect = 3e-20
 Identities = 65/185 (35%), Positives = 95/185 (51%), Gaps = 3/185 (1%)

Query: 102 QSQAQVEPVGLEMF--LKAAAENQEYLIDKYLTD-GGDPNAHDKLHRTALHWACLKGHSQ 158
           Q  A+++ + L+    L  AA    + + K L D G  PN+      T LH AC K H +
Sbjct: 326 QYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVR 385

Query: 159 LVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAV 218
           ++  LL  GA++DA      TP+  A   GHL I+K LL +GA  N  +    TPLH+A 
Sbjct: 386 VMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAA 445

Query: 219 RTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVT 278
           R  H +  ++L++  A +NA+ K+  T LH A R G    +KLLL   A   +   A  T
Sbjct: 446 RAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHT 505

Query: 279 PVQLA 283
           P+ +A
Sbjct: 506 PLHIA 510



 Score = 89.0 bits (219), Expect = 5e-18
 Identities = 67/215 (31%), Positives = 97/215 (45%), Gaps = 4/215 (1%)

Query: 88  HRVPPRKPEPLVKPQSQAQVEPVGLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTA 147
           HRV     +   KP S+A      L +   A  +N   +++  L  G   +A  +   T 
Sbjct: 351 HRVAKVLLDKGAKPNSRALNGFTPLHI---ACKKNHVRVMELLLKTGASIDAVTESGLTP 407

Query: 148 LHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARD 207
           LH A   GH  +V  LL  GA+ +  ++   TP+  A R GH  + K LL   A+VNA+ 
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467

Query: 208 KIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGA 267
           K   TPLH A R  H + ++ L+E  A+ N     G T LH A R G  + +  LL   A
Sbjct: 468 KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA 527

Query: 268 ELGVRNAASVTPVQLARDWQR-GIREALQAHVAHP 301
                     TP+ +A  + +  + E L    AHP
Sbjct: 528 SQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP 562



 Score = 85.1 bits (209), Expect = 7e-17
 Identities = 52/158 (32%), Positives = 76/158 (48%)

Query: 126 LIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWAC 185
           ++   L  G  PN  +    T LH A   GH+++   LL   A V+A+   D+TP+  A 
Sbjct: 419 IVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAA 478

Query: 186 RGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDT 245
           R GH  ++K LL   A  N     G TPLH+A R  H + +  L+E  A      K+G T
Sbjct: 479 RIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFT 538

Query: 246 ALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
            LH A ++G  +  +LLL   A         +TP+ +A
Sbjct: 539 PLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVA 576



 Score = 83.6 bits (205), Expect = 2e-16
 Identities = 60/169 (35%), Positives = 81/169 (47%), Gaps = 1/169 (0%)

Query: 116 LKAAAENQEYLIDKYLTDGGDP-NAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARD 174
           L  AA N    I + L D G P  A  K   + +H A    H   V  LL   A +D   
Sbjct: 276 LHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDIT 335

Query: 175 LLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGA 234
           L   TP+  A   GH  + K LL++GA+ N+R   G TPLH+A +  H   +E L++ GA
Sbjct: 336 LDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGA 395

Query: 235 HLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
            ++A  + G T LH A   G    +K LL  GA   V N    TP+ +A
Sbjct: 396 SIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA 444



 Score = 80.9 bits (198), Expect = 1e-15
 Identities = 52/167 (31%), Positives = 84/167 (50%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLD 177
           AA +NQ  +    L  GG  NA      T LH A  +GH+++V  LL   A  +  +   
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 668

Query: 178 RTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLN 237
            TP+    + GH+ +   L+  G  V+A  ++G TPLHVA    +   ++ L++  A +N
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 728

Query: 238 AQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLAR 284
           A+ K G + LH+A + G    + LLL  GA     ++   TP+ +A+
Sbjct: 729 AKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAK 775



 Score = 79.0 bits (193), Expect = 5e-15
 Identities = 66/192 (34%), Positives = 83/192 (43%), Gaps = 5/192 (2%)

Query: 97  PLVKPQSQAQVEP----VGLEMFLKAAAENQEYLIDKYLTDG-GDPNAHDKLHRTALHWA 151
           P+VK   Q    P    V +E  L  AA      + KYL       NA  K  +T LH A
Sbjct: 418 PIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCA 477

Query: 152 CLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGS 211
              GH+ +V  LL   A  +       TP+  A R GH+  +  LL + A      K G 
Sbjct: 478 ARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGF 537

Query: 212 TPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGV 271
           TPLHVA +       E L+E  AH NA  K G T LH AV H +   +KLLL  G     
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597

Query: 272 RNAASVTPVQLA 283
                 TP+ +A
Sbjct: 598 PAWNGYTPLHIA 609



 Score = 77.8 bits (190), Expect = 1e-14
 Identities = 46/138 (33%), Positives = 75/138 (54%)

Query: 146 TALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNA 205
           T LH A  +G+  +V  LL  GA ++ +   + TP+  A R GH+ I + LL+ GA + A
Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300

Query: 206 RDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLY 265
           + K G +P+H+A +  H DC+  L++  A ++    +  T LH A   G ++  K+LL  
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360

Query: 266 GAELGVRNAASVTPVQLA 283
           GA+   R     TP+ +A
Sbjct: 361 GAKPNSRALNGFTPLHIA 378



 Score = 75.1 bits (183), Expect = 7e-14
 Identities = 49/173 (28%), Positives = 82/173 (47%)

Query: 111 GLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATV 170
           GL     A   N   ++   L  GG P++      T LH A  +   ++   LL  G + 
Sbjct: 569 GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA 628

Query: 171 DARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLI 230
           +A  +   TP+  A + GH  ++  LL++ A  N  +K G TPLH+  +  H    + LI
Sbjct: 629 NAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLI 688

Query: 231 ECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
           + G  ++A  + G T LH A  +G+ K +K LL + A++  +     +P+  A
Sbjct: 689 KHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQA 741



 Score = 73.2 bits (178), Expect = 3e-13
 Identities = 48/146 (32%), Positives = 73/146 (50%), Gaps = 4/146 (2%)

Query: 142 KLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGA 201
           K   TALH A L G  ++V +L+  GA V+A+     TP++ A +  HL ++K LL  GA
Sbjct: 76  KKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGA 135

Query: 202 RVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKL 261
             N   + G TPL VA++  H + + HLI  G     + K    ALH A R+   +   +
Sbjct: 136 NQNVATEDGFTPLAVALQQGHENVVAHLINYGT----KGKVRLPALHIAARNDDTRTAAV 191

Query: 262 LLLYGAELGVRNAASVTPVQLARDWQ 287
           LL       V +    TP+ +A  ++
Sbjct: 192 LLQNDPNPDVLSKTGFTPLHIAAHYE 217



 Score = 72.4 bits (176), Expect = 5e-13
 Identities = 49/159 (30%), Positives = 85/159 (53%), Gaps = 2/159 (1%)

Query: 115 FLKAAAE-NQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDAR 173
           FL+AA   N +  +D +L +G D N  ++     LH A  +GH ++V +LL     ++  
Sbjct: 16  FLRAARSGNLDKALD-HLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETT 74

Query: 174 DLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECG 233
                T +  A   G   ++++L+N GA VNA+ + G TPL++A +  H + ++ L+E G
Sbjct: 75  TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENG 134

Query: 234 AHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVR 272
           A+ N   ++G T L  A++ G    +  L+ YG +  VR
Sbjct: 135 ANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR 173



 Score = 72.4 bits (176), Expect = 5e-13
 Identities = 47/153 (30%), Positives = 79/153 (51%)

Query: 131 LTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHL 190
           L +  +P+   K   T LH A    +  +   LL  GA+V+       TP+  A R G++
Sbjct: 193 LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNV 252

Query: 191 VILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEA 250
           ++++ LL++GA++  + K   TPLH A R  H    E L++ GA + A+ K G + +H A
Sbjct: 253 IMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 312

Query: 251 VRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
            +      ++LLL Y AE+       +TP+ +A
Sbjct: 313 AQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVA 345



 Score = 72.0 bits (175), Expect = 6e-13
 Identities = 50/166 (30%), Positives = 74/166 (44%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLD 177
           AA      ++   L +  +PN       T LH A  +GH + V  LL   A+        
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536

Query: 178 RTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLN 237
            TP+  A + G + + + LL + A  NA  K G TPLHVAV   + D ++ L+  G   +
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596

Query: 238 AQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
           +    G T LH A +    +  + LL YG      +   VTP+ LA
Sbjct: 597 SPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLA 642



 Score = 70.9 bits (172), Expect = 1e-12
 Identities = 48/166 (28%), Positives = 75/166 (45%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLD 177
           A+      ++   L  G       K   T LH A   GH ++   LL  GA + A+    
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305

Query: 178 RTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLN 237
            +P+  A +G HL  ++ LL   A ++       TPLHVA    H    + L++ GA  N
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365

Query: 238 AQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
           ++   G T LH A +    + M+LLL  GA +     + +TP+ +A
Sbjct: 366 SRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVA 411



 Score = 70.1 bits (170), Expect = 2e-12
 Identities = 45/137 (32%), Positives = 68/137 (49%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLD 177
           AA E    ++   L+   + N  +K   T LH    +GH  + + L+  G  VDA   + 
Sbjct: 642 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 701

Query: 178 RTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLN 237
            TP+  A   G++ ++K LL   A VNA+ K+G +PLH A +  H D +  L++ GA  N
Sbjct: 702 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761

Query: 238 AQDKEGDTALHEAVRHG 254
               +G T L  A R G
Sbjct: 762 EVSSDGTTPLAIAKRLG 778



 Score = 65.5 bits (158), Expect = 6e-11
 Identities = 58/214 (27%), Positives = 96/214 (44%), Gaps = 34/214 (15%)

Query: 99  VKPQSQAQVEPVGLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQ 158
           V  QSQ    P+ +     AA EN   ++   L +G + N   +   T L  A  +GH  
Sbjct: 104 VNAQSQKGFTPLYM-----AAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHEN 158

Query: 159 LVNKLL--------------VAGATVDAR------------DLLDRT---PVFWACRGGH 189
           +V  L+              +A    D R            D+L +T   P+  A    +
Sbjct: 159 VVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYEN 218

Query: 190 LVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHE 249
           L + + LLN+GA VN   + G TPLH+A R  +   +  L++ GA +  + K+  T LH 
Sbjct: 219 LNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHC 278

Query: 250 AVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
           A R+G  +  ++LL +GA +  +    ++P+ +A
Sbjct: 279 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 312



 Score = 65.1 bits (157), Expect = 7e-11
 Identities = 50/186 (26%), Positives = 77/186 (41%)

Query: 98  LVKPQSQAQVEPVGLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHS 157
           L K  SQA +   G      AA   +  + +  L     PNA  K   T LH A    + 
Sbjct: 523 LEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNL 582

Query: 158 QLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVA 217
            +V  LL  G +  +      TP+  A +   + + + LL  G   NA    G TPLH+A
Sbjct: 583 DIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLA 642

Query: 218 VRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASV 277
            +  H + +  L+   A+ N  +K G T LH   + G      +L+ +G  +        
Sbjct: 643 AQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGY 702

Query: 278 TPVQLA 283
           TP+ +A
Sbjct: 703 TPLHVA 708



 Score = 56.2 bits (134), Expect = 3e-08
 Identities = 36/121 (29%), Positives = 64/121 (52%), Gaps = 3/121 (2%)

Query: 184 ACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEG 243
           A + GH+ ++ +LL++   +    K G+T LH+A      + +  L+  GA++NAQ ++G
Sbjct: 52  ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 111

Query: 244 DTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLARDWQRGIREALQAHVAHPRT 303
            T L+ A +    + +K LL  GA   V      TP+ +A   Q+G  E + AH+ +  T
Sbjct: 112 FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA--LQQG-HENVVAHLINYGT 168

Query: 304 R 304
           +
Sbjct: 169 K 169



 Score = 47.8 bits (112), Expect = 1e-05
 Identities = 32/115 (27%), Positives = 53/115 (46%)

Query: 169 TVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEH 228
           +V  R+    T    A R G+L      L  G  +N  ++ G   LH+A +  H   +  
Sbjct: 4   SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63

Query: 229 LIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
           L+     L    K+G+TALH A   G  + ++ L+ YGA +  ++    TP+ +A
Sbjct: 64  LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMA 118



 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 36/109 (33%), Positives = 51/109 (46%)

Query: 111 GLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATV 170
           GL      A E    + D  +  G   +A  ++  T LH A   G+ +LV  LL   A V
Sbjct: 668 GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADV 727

Query: 171 DARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVR 219
           +A+  L  +P+  A + GH  I+  LL  GA  N     G+TPL +A R
Sbjct: 728 NAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKR 776



 Score = 34.3 bits (77), Expect = 0.14
 Identities = 27/86 (31%), Positives = 42/86 (48%), Gaps = 3/86 (3%)

Query: 126 LIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWAC 185
           L+   L    D NA  KL  + LH A  +GH+ +V  LL  GA+ +       TP+  A 
Sbjct: 716 LVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAK 775

Query: 186 RGGHLV---ILKQLLNQGARVNARDK 208
           R G++    +LK + ++ + V   DK
Sbjct: 776 RLGYISVTDVLKVVTDETSFVLVSDK 801


>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
          Length = 1719

 Score = 96.3 bits (238), Expect = 3e-20
 Identities = 65/185 (35%), Positives = 95/185 (51%), Gaps = 3/185 (1%)

Query: 102 QSQAQVEPVGLEMF--LKAAAENQEYLIDKYLTD-GGDPNAHDKLHRTALHWACLKGHSQ 158
           Q  A+++ + L+    L  AA    + + K L D G  PN+      T LH AC K H +
Sbjct: 326 QYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVR 385

Query: 159 LVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAV 218
           ++  LL  GA++DA      TP+  A   GHL I+K LL +GA  N  +    TPLH+A 
Sbjct: 386 VMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAA 445

Query: 219 RTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVT 278
           R  H +  ++L++  A +NA+ K+  T LH A R G    +KLLL   A   +   A  T
Sbjct: 446 RAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHT 505

Query: 279 PVQLA 283
           P+ +A
Sbjct: 506 PLHIA 510



 Score = 89.0 bits (219), Expect = 5e-18
 Identities = 67/215 (31%), Positives = 97/215 (45%), Gaps = 4/215 (1%)

Query: 88  HRVPPRKPEPLVKPQSQAQVEPVGLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTA 147
           HRV     +   KP S+A      L +   A  +N   +++  L  G   +A  +   T 
Sbjct: 351 HRVAKVLLDKGAKPNSRALNGFTPLHI---ACKKNHVRVMELLLKTGASIDAVTESGLTP 407

Query: 148 LHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARD 207
           LH A   GH  +V  LL  GA+ +  ++   TP+  A R GH  + K LL   A+VNA+ 
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467

Query: 208 KIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGA 267
           K   TPLH A R  H + ++ L+E  A+ N     G T LH A R G  + +  LL   A
Sbjct: 468 KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA 527

Query: 268 ELGVRNAASVTPVQLARDWQR-GIREALQAHVAHP 301
                     TP+ +A  + +  + E L    AHP
Sbjct: 528 SQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP 562



 Score = 85.1 bits (209), Expect = 7e-17
 Identities = 52/158 (32%), Positives = 76/158 (48%)

Query: 126 LIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWAC 185
           ++   L  G  PN  +    T LH A   GH+++   LL   A V+A+   D+TP+  A 
Sbjct: 419 IVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAA 478

Query: 186 RGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDT 245
           R GH  ++K LL   A  N     G TPLH+A R  H + +  L+E  A      K+G T
Sbjct: 479 RIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFT 538

Query: 246 ALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
            LH A ++G  +  +LLL   A         +TP+ +A
Sbjct: 539 PLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVA 576



 Score = 83.6 bits (205), Expect = 2e-16
 Identities = 60/169 (35%), Positives = 81/169 (47%), Gaps = 1/169 (0%)

Query: 116 LKAAAENQEYLIDKYLTDGGDP-NAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARD 174
           L  AA N    I + L D G P  A  K   + +H A    H   V  LL   A +D   
Sbjct: 276 LHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDIT 335

Query: 175 LLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGA 234
           L   TP+  A   GH  + K LL++GA+ N+R   G TPLH+A +  H   +E L++ GA
Sbjct: 336 LDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGA 395

Query: 235 HLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
            ++A  + G T LH A   G    +K LL  GA   V N    TP+ +A
Sbjct: 396 SIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA 444



 Score = 80.9 bits (198), Expect = 1e-15
 Identities = 52/167 (31%), Positives = 84/167 (50%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLD 177
           AA +NQ  +    L  GG  NA      T LH A  +GH+++V  LL   A  +  +   
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 668

Query: 178 RTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLN 237
            TP+    + GH+ +   L+  G  V+A  ++G TPLHVA    +   ++ L++  A +N
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 728

Query: 238 AQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLAR 284
           A+ K G + LH+A + G    + LLL  GA     ++   TP+ +A+
Sbjct: 729 AKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAK 775



 Score = 79.0 bits (193), Expect = 5e-15
 Identities = 66/192 (34%), Positives = 83/192 (43%), Gaps = 5/192 (2%)

Query: 97  PLVKPQSQAQVEP----VGLEMFLKAAAENQEYLIDKYLTDG-GDPNAHDKLHRTALHWA 151
           P+VK   Q    P    V +E  L  AA      + KYL       NA  K  +T LH A
Sbjct: 418 PIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCA 477

Query: 152 CLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGS 211
              GH+ +V  LL   A  +       TP+  A R GH+  +  LL + A      K G 
Sbjct: 478 ARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGF 537

Query: 212 TPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGV 271
           TPLHVA +       E L+E  AH NA  K G T LH AV H +   +KLLL  G     
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597

Query: 272 RNAASVTPVQLA 283
                 TP+ +A
Sbjct: 598 PAWNGYTPLHIA 609



 Score = 77.8 bits (190), Expect = 1e-14
 Identities = 46/138 (33%), Positives = 75/138 (54%)

Query: 146 TALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNA 205
           T LH A  +G+  +V  LL  GA ++ +   + TP+  A R GH+ I + LL+ GA + A
Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300

Query: 206 RDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLY 265
           + K G +P+H+A +  H DC+  L++  A ++    +  T LH A   G ++  K+LL  
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360

Query: 266 GAELGVRNAASVTPVQLA 283
           GA+   R     TP+ +A
Sbjct: 361 GAKPNSRALNGFTPLHIA 378



 Score = 75.1 bits (183), Expect = 7e-14
 Identities = 49/173 (28%), Positives = 82/173 (47%)

Query: 111 GLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATV 170
           GL     A   N   ++   L  GG P++      T LH A  +   ++   LL  G + 
Sbjct: 569 GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA 628

Query: 171 DARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLI 230
           +A  +   TP+  A + GH  ++  LL++ A  N  +K G TPLH+  +  H    + LI
Sbjct: 629 NAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLI 688

Query: 231 ECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
           + G  ++A  + G T LH A  +G+ K +K LL + A++  +     +P+  A
Sbjct: 689 KHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQA 741



 Score = 73.2 bits (178), Expect = 3e-13
 Identities = 48/146 (32%), Positives = 73/146 (50%), Gaps = 4/146 (2%)

Query: 142 KLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGA 201
           K   TALH A L G  ++V +L+  GA V+A+     TP++ A +  HL ++K LL  GA
Sbjct: 76  KKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGA 135

Query: 202 RVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKL 261
             N   + G TPL VA++  H + + HLI  G     + K    ALH A R+   +   +
Sbjct: 136 NQNVATEDGFTPLAVALQQGHENVVAHLINYGT----KGKVRLPALHIAARNDDTRTAAV 191

Query: 262 LLLYGAELGVRNAASVTPVQLARDWQ 287
           LL       V +    TP+ +A  ++
Sbjct: 192 LLQNDPNPDVLSKTGFTPLHIAAHYE 217



 Score = 72.4 bits (176), Expect = 5e-13
 Identities = 49/159 (30%), Positives = 85/159 (53%), Gaps = 2/159 (1%)

Query: 115 FLKAAAE-NQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDAR 173
           FL+AA   N +  +D +L +G D N  ++     LH A  +GH ++V +LL     ++  
Sbjct: 16  FLRAARSGNLDKALD-HLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETT 74

Query: 174 DLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECG 233
                T +  A   G   ++++L+N GA VNA+ + G TPL++A +  H + ++ L+E G
Sbjct: 75  TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENG 134

Query: 234 AHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVR 272
           A+ N   ++G T L  A++ G    +  L+ YG +  VR
Sbjct: 135 ANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR 173



 Score = 72.4 bits (176), Expect = 5e-13
 Identities = 47/153 (30%), Positives = 79/153 (51%)

Query: 131 LTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHL 190
           L +  +P+   K   T LH A    +  +   LL  GA+V+       TP+  A R G++
Sbjct: 193 LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNV 252

Query: 191 VILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEA 250
           ++++ LL++GA++  + K   TPLH A R  H    E L++ GA + A+ K G + +H A
Sbjct: 253 IMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 312

Query: 251 VRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
            +      ++LLL Y AE+       +TP+ +A
Sbjct: 313 AQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVA 345



 Score = 72.0 bits (175), Expect = 6e-13
 Identities = 50/166 (30%), Positives = 74/166 (44%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLD 177
           AA      ++   L +  +PN       T LH A  +GH + V  LL   A+        
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536

Query: 178 RTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLN 237
            TP+  A + G + + + LL + A  NA  K G TPLHVAV   + D ++ L+  G   +
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596

Query: 238 AQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
           +    G T LH A +    +  + LL YG      +   VTP+ LA
Sbjct: 597 SPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLA 642



 Score = 70.9 bits (172), Expect = 1e-12
 Identities = 48/166 (28%), Positives = 75/166 (45%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLD 177
           A+      ++   L  G       K   T LH A   GH ++   LL  GA + A+    
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305

Query: 178 RTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLN 237
            +P+  A +G HL  ++ LL   A ++       TPLHVA    H    + L++ GA  N
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365

Query: 238 AQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
           ++   G T LH A +    + M+LLL  GA +     + +TP+ +A
Sbjct: 366 SRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVA 411



 Score = 70.1 bits (170), Expect = 2e-12
 Identities = 45/137 (32%), Positives = 68/137 (49%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLD 177
           AA E    ++   L+   + N  +K   T LH    +GH  + + L+  G  VDA   + 
Sbjct: 642 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 701

Query: 178 RTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLN 237
            TP+  A   G++ ++K LL   A VNA+ K+G +PLH A +  H D +  L++ GA  N
Sbjct: 702 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761

Query: 238 AQDKEGDTALHEAVRHG 254
               +G T L  A R G
Sbjct: 762 EVSSDGTTPLAIAKRLG 778



 Score = 65.5 bits (158), Expect = 6e-11
 Identities = 58/214 (27%), Positives = 96/214 (44%), Gaps = 34/214 (15%)

Query: 99  VKPQSQAQVEPVGLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQ 158
           V  QSQ    P+ +     AA EN   ++   L +G + N   +   T L  A  +GH  
Sbjct: 104 VNAQSQKGFTPLYM-----AAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHEN 158

Query: 159 LVNKLL--------------VAGATVDAR------------DLLDRT---PVFWACRGGH 189
           +V  L+              +A    D R            D+L +T   P+  A    +
Sbjct: 159 VVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYEN 218

Query: 190 LVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHE 249
           L + + LLN+GA VN   + G TPLH+A R  +   +  L++ GA +  + K+  T LH 
Sbjct: 219 LNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHC 278

Query: 250 AVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
           A R+G  +  ++LL +GA +  +    ++P+ +A
Sbjct: 279 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 312



 Score = 65.1 bits (157), Expect = 7e-11
 Identities = 50/186 (26%), Positives = 77/186 (41%)

Query: 98  LVKPQSQAQVEPVGLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHS 157
           L K  SQA +   G      AA   +  + +  L     PNA  K   T LH A    + 
Sbjct: 523 LEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNL 582

Query: 158 QLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVA 217
            +V  LL  G +  +      TP+  A +   + + + LL  G   NA    G TPLH+A
Sbjct: 583 DIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLA 642

Query: 218 VRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASV 277
            +  H + +  L+   A+ N  +K G T LH   + G      +L+ +G  +        
Sbjct: 643 AQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGY 702

Query: 278 TPVQLA 283
           TP+ +A
Sbjct: 703 TPLHVA 708



 Score = 56.2 bits (134), Expect = 3e-08
 Identities = 36/121 (29%), Positives = 64/121 (52%), Gaps = 3/121 (2%)

Query: 184 ACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEG 243
           A + GH+ ++ +LL++   +    K G+T LH+A      + +  L+  GA++NAQ ++G
Sbjct: 52  ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 111

Query: 244 DTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLARDWQRGIREALQAHVAHPRT 303
            T L+ A +    + +K LL  GA   V      TP+ +A   Q+G  E + AH+ +  T
Sbjct: 112 FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA--LQQG-HENVVAHLINYGT 168

Query: 304 R 304
           +
Sbjct: 169 K 169



 Score = 47.8 bits (112), Expect = 1e-05
 Identities = 32/115 (27%), Positives = 53/115 (46%)

Query: 169 TVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEH 228
           +V  R+    T    A R G+L      L  G  +N  ++ G   LH+A +  H   +  
Sbjct: 4   SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63

Query: 229 LIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
           L+     L    K+G+TALH A   G  + ++ L+ YGA +  ++    TP+ +A
Sbjct: 64  LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMA 118



 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 36/109 (33%), Positives = 51/109 (46%)

Query: 111 GLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATV 170
           GL      A E    + D  +  G   +A  ++  T LH A   G+ +LV  LL   A V
Sbjct: 668 GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADV 727

Query: 171 DARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVR 219
           +A+  L  +P+  A + GH  I+  LL  GA  N     G+TPL +A R
Sbjct: 728 NAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKR 776



 Score = 34.3 bits (77), Expect = 0.14
 Identities = 27/86 (31%), Positives = 42/86 (48%), Gaps = 3/86 (3%)

Query: 126 LIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWAC 185
           L+   L    D NA  KL  + LH A  +GH+ +V  LL  GA+ +       TP+  A 
Sbjct: 716 LVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAK 775

Query: 186 RGGHLV---ILKQLLNQGARVNARDK 208
           R G++    +LK + ++ + V   DK
Sbjct: 776 RLGYISVTDVLKVVTDETSFVLVSDK 801


>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
          Length = 1856

 Score = 96.3 bits (238), Expect = 3e-20
 Identities = 65/185 (35%), Positives = 95/185 (51%), Gaps = 3/185 (1%)

Query: 102 QSQAQVEPVGLEMF--LKAAAENQEYLIDKYLTD-GGDPNAHDKLHRTALHWACLKGHSQ 158
           Q  A+++ + L+    L  AA    + + K L D G  PN+      T LH AC K H +
Sbjct: 326 QYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVR 385

Query: 159 LVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAV 218
           ++  LL  GA++DA      TP+  A   GHL I+K LL +GA  N  +    TPLH+A 
Sbjct: 386 VMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAA 445

Query: 219 RTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVT 278
           R  H +  ++L++  A +NA+ K+  T LH A R G    +KLLL   A   +   A  T
Sbjct: 446 RAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHT 505

Query: 279 PVQLA 283
           P+ +A
Sbjct: 506 PLHIA 510



 Score = 89.0 bits (219), Expect = 5e-18
 Identities = 67/215 (31%), Positives = 97/215 (45%), Gaps = 4/215 (1%)

Query: 88  HRVPPRKPEPLVKPQSQAQVEPVGLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTA 147
           HRV     +   KP S+A      L +   A  +N   +++  L  G   +A  +   T 
Sbjct: 351 HRVAKVLLDKGAKPNSRALNGFTPLHI---ACKKNHVRVMELLLKTGASIDAVTESGLTP 407

Query: 148 LHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARD 207
           LH A   GH  +V  LL  GA+ +  ++   TP+  A R GH  + K LL   A+VNA+ 
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467

Query: 208 KIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGA 267
           K   TPLH A R  H + ++ L+E  A+ N     G T LH A R G  + +  LL   A
Sbjct: 468 KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA 527

Query: 268 ELGVRNAASVTPVQLARDWQR-GIREALQAHVAHP 301
                     TP+ +A  + +  + E L    AHP
Sbjct: 528 SQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP 562



 Score = 85.1 bits (209), Expect = 7e-17
 Identities = 52/158 (32%), Positives = 76/158 (48%)

Query: 126 LIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWAC 185
           ++   L  G  PN  +    T LH A   GH+++   LL   A V+A+   D+TP+  A 
Sbjct: 419 IVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAA 478

Query: 186 RGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDT 245
           R GH  ++K LL   A  N     G TPLH+A R  H + +  L+E  A      K+G T
Sbjct: 479 RIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFT 538

Query: 246 ALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
            LH A ++G  +  +LLL   A         +TP+ +A
Sbjct: 539 PLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVA 576



 Score = 83.6 bits (205), Expect = 2e-16
 Identities = 60/169 (35%), Positives = 81/169 (47%), Gaps = 1/169 (0%)

Query: 116 LKAAAENQEYLIDKYLTDGGDP-NAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARD 174
           L  AA N    I + L D G P  A  K   + +H A    H   V  LL   A +D   
Sbjct: 276 LHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDIT 335

Query: 175 LLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGA 234
           L   TP+  A   GH  + K LL++GA+ N+R   G TPLH+A +  H   +E L++ GA
Sbjct: 336 LDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGA 395

Query: 235 HLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
            ++A  + G T LH A   G    +K LL  GA   V N    TP+ +A
Sbjct: 396 SIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA 444



 Score = 80.9 bits (198), Expect = 1e-15
 Identities = 52/167 (31%), Positives = 84/167 (50%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLD 177
           AA +NQ  +    L  GG  NA      T LH A  +GH+++V  LL   A  +  +   
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 668

Query: 178 RTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLN 237
            TP+    + GH+ +   L+  G  V+A  ++G TPLHVA    +   ++ L++  A +N
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 728

Query: 238 AQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLAR 284
           A+ K G + LH+A + G    + LLL  GA     ++   TP+ +A+
Sbjct: 729 AKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAK 775



 Score = 79.0 bits (193), Expect = 5e-15
 Identities = 66/192 (34%), Positives = 83/192 (43%), Gaps = 5/192 (2%)

Query: 97  PLVKPQSQAQVEP----VGLEMFLKAAAENQEYLIDKYLTDG-GDPNAHDKLHRTALHWA 151
           P+VK   Q    P    V +E  L  AA      + KYL       NA  K  +T LH A
Sbjct: 418 PIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCA 477

Query: 152 CLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGS 211
              GH+ +V  LL   A  +       TP+  A R GH+  +  LL + A      K G 
Sbjct: 478 ARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGF 537

Query: 212 TPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGV 271
           TPLHVA +       E L+E  AH NA  K G T LH AV H +   +KLLL  G     
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597

Query: 272 RNAASVTPVQLA 283
                 TP+ +A
Sbjct: 598 PAWNGYTPLHIA 609



 Score = 77.8 bits (190), Expect = 1e-14
 Identities = 46/138 (33%), Positives = 75/138 (54%)

Query: 146 TALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNA 205
           T LH A  +G+  +V  LL  GA ++ +   + TP+  A R GH+ I + LL+ GA + A
Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300

Query: 206 RDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLY 265
           + K G +P+H+A +  H DC+  L++  A ++    +  T LH A   G ++  K+LL  
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360

Query: 266 GAELGVRNAASVTPVQLA 283
           GA+   R     TP+ +A
Sbjct: 361 GAKPNSRALNGFTPLHIA 378



 Score = 75.1 bits (183), Expect = 7e-14
 Identities = 49/173 (28%), Positives = 82/173 (47%)

Query: 111 GLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATV 170
           GL     A   N   ++   L  GG P++      T LH A  +   ++   LL  G + 
Sbjct: 569 GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA 628

Query: 171 DARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLI 230
           +A  +   TP+  A + GH  ++  LL++ A  N  +K G TPLH+  +  H    + LI
Sbjct: 629 NAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLI 688

Query: 231 ECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
           + G  ++A  + G T LH A  +G+ K +K LL + A++  +     +P+  A
Sbjct: 689 KHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQA 741



 Score = 73.2 bits (178), Expect = 3e-13
 Identities = 48/146 (32%), Positives = 73/146 (50%), Gaps = 4/146 (2%)

Query: 142 KLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGA 201
           K   TALH A L G  ++V +L+  GA V+A+     TP++ A +  HL ++K LL  GA
Sbjct: 76  KKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGA 135

Query: 202 RVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKL 261
             N   + G TPL VA++  H + + HLI  G     + K    ALH A R+   +   +
Sbjct: 136 NQNVATEDGFTPLAVALQQGHENVVAHLINYGT----KGKVRLPALHIAARNDDTRTAAV 191

Query: 262 LLLYGAELGVRNAASVTPVQLARDWQ 287
           LL       V +    TP+ +A  ++
Sbjct: 192 LLQNDPNPDVLSKTGFTPLHIAAHYE 217



 Score = 72.4 bits (176), Expect = 5e-13
 Identities = 49/159 (30%), Positives = 85/159 (53%), Gaps = 2/159 (1%)

Query: 115 FLKAAAE-NQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDAR 173
           FL+AA   N +  +D +L +G D N  ++     LH A  +GH ++V +LL     ++  
Sbjct: 16  FLRAARSGNLDKALD-HLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETT 74

Query: 174 DLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECG 233
                T +  A   G   ++++L+N GA VNA+ + G TPL++A +  H + ++ L+E G
Sbjct: 75  TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENG 134

Query: 234 AHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVR 272
           A+ N   ++G T L  A++ G    +  L+ YG +  VR
Sbjct: 135 ANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR 173



 Score = 72.4 bits (176), Expect = 5e-13
 Identities = 47/153 (30%), Positives = 79/153 (51%)

Query: 131 LTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHL 190
           L +  +P+   K   T LH A    +  +   LL  GA+V+       TP+  A R G++
Sbjct: 193 LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNV 252

Query: 191 VILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEA 250
           ++++ LL++GA++  + K   TPLH A R  H    E L++ GA + A+ K G + +H A
Sbjct: 253 IMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 312

Query: 251 VRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
            +      ++LLL Y AE+       +TP+ +A
Sbjct: 313 AQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVA 345



 Score = 72.0 bits (175), Expect = 6e-13
 Identities = 50/166 (30%), Positives = 74/166 (44%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLD 177
           AA      ++   L +  +PN       T LH A  +GH + V  LL   A+        
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536

Query: 178 RTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLN 237
            TP+  A + G + + + LL + A  NA  K G TPLHVAV   + D ++ L+  G   +
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596

Query: 238 AQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
           +    G T LH A +    +  + LL YG      +   VTP+ LA
Sbjct: 597 SPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLA 642



 Score = 70.9 bits (172), Expect = 1e-12
 Identities = 48/166 (28%), Positives = 75/166 (45%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLD 177
           A+      ++   L  G       K   T LH A   GH ++   LL  GA + A+    
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305

Query: 178 RTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLN 237
            +P+  A +G HL  ++ LL   A ++       TPLHVA    H    + L++ GA  N
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365

Query: 238 AQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
           ++   G T LH A +    + M+LLL  GA +     + +TP+ +A
Sbjct: 366 SRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVA 411



 Score = 70.1 bits (170), Expect = 2e-12
 Identities = 45/137 (32%), Positives = 68/137 (49%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLD 177
           AA E    ++   L+   + N  +K   T LH    +GH  + + L+  G  VDA   + 
Sbjct: 642 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 701

Query: 178 RTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLN 237
            TP+  A   G++ ++K LL   A VNA+ K+G +PLH A +  H D +  L++ GA  N
Sbjct: 702 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761

Query: 238 AQDKEGDTALHEAVRHG 254
               +G T L  A R G
Sbjct: 762 EVSSDGTTPLAIAKRLG 778



 Score = 65.5 bits (158), Expect = 6e-11
 Identities = 58/214 (27%), Positives = 96/214 (44%), Gaps = 34/214 (15%)

Query: 99  VKPQSQAQVEPVGLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQ 158
           V  QSQ    P+ +     AA EN   ++   L +G + N   +   T L  A  +GH  
Sbjct: 104 VNAQSQKGFTPLYM-----AAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHEN 158

Query: 159 LVNKLL--------------VAGATVDAR------------DLLDRT---PVFWACRGGH 189
           +V  L+              +A    D R            D+L +T   P+  A    +
Sbjct: 159 VVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYEN 218

Query: 190 LVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHE 249
           L + + LLN+GA VN   + G TPLH+A R  +   +  L++ GA +  + K+  T LH 
Sbjct: 219 LNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHC 278

Query: 250 AVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
           A R+G  +  ++LL +GA +  +    ++P+ +A
Sbjct: 279 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 312



 Score = 65.1 bits (157), Expect = 7e-11
 Identities = 50/186 (26%), Positives = 77/186 (41%)

Query: 98  LVKPQSQAQVEPVGLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHS 157
           L K  SQA +   G      AA   +  + +  L     PNA  K   T LH A    + 
Sbjct: 523 LEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNL 582

Query: 158 QLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVA 217
            +V  LL  G +  +      TP+  A +   + + + LL  G   NA    G TPLH+A
Sbjct: 583 DIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLA 642

Query: 218 VRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASV 277
            +  H + +  L+   A+ N  +K G T LH   + G      +L+ +G  +        
Sbjct: 643 AQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGY 702

Query: 278 TPVQLA 283
           TP+ +A
Sbjct: 703 TPLHVA 708



 Score = 56.2 bits (134), Expect = 3e-08
 Identities = 36/121 (29%), Positives = 64/121 (52%), Gaps = 3/121 (2%)

Query: 184 ACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEG 243
           A + GH+ ++ +LL++   +    K G+T LH+A      + +  L+  GA++NAQ ++G
Sbjct: 52  ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 111

Query: 244 DTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLARDWQRGIREALQAHVAHPRT 303
            T L+ A +    + +K LL  GA   V      TP+ +A   Q+G  E + AH+ +  T
Sbjct: 112 FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA--LQQG-HENVVAHLINYGT 168

Query: 304 R 304
           +
Sbjct: 169 K 169



 Score = 47.8 bits (112), Expect = 1e-05
 Identities = 32/115 (27%), Positives = 53/115 (46%)

Query: 169 TVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEH 228
           +V  R+    T    A R G+L      L  G  +N  ++ G   LH+A +  H   +  
Sbjct: 4   SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63

Query: 229 LIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
           L+     L    K+G+TALH A   G  + ++ L+ YGA +  ++    TP+ +A
Sbjct: 64  LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMA 118



 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 36/109 (33%), Positives = 51/109 (46%)

Query: 111 GLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATV 170
           GL      A E    + D  +  G   +A  ++  T LH A   G+ +LV  LL   A V
Sbjct: 668 GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADV 727

Query: 171 DARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVR 219
           +A+  L  +P+  A + GH  I+  LL  GA  N     G+TPL +A R
Sbjct: 728 NAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKR 776



 Score = 34.3 bits (77), Expect = 0.14
 Identities = 27/86 (31%), Positives = 42/86 (48%), Gaps = 3/86 (3%)

Query: 126 LIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWAC 185
           L+   L    D NA  KL  + LH A  +GH+ +V  LL  GA+ +       TP+  A 
Sbjct: 716 LVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAK 775

Query: 186 RGGHLV---ILKQLLNQGARVNARDK 208
           R G++    +LK + ++ + V   DK
Sbjct: 776 RLGYISVTDVLKVVTDETSFVLVSDK 801


>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
           sapiens]
          Length = 1771

 Score = 95.1 bits (235), Expect = 7e-20
 Identities = 54/166 (32%), Positives = 84/166 (50%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLD 177
           AA      ++   L +G   N  DK   T L WA  KGH + V  LL  GA VD      
Sbjct: 144 AAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANS 203

Query: 178 RTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLN 237
            T +  A +GG+   +K++L +   VN  DK G+T L +A +  H + ++ L++ G ++N
Sbjct: 204 MTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVN 263

Query: 238 AQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
             D+ GDT L  AVR G  + ++ LL   A++ +R   + T +  A
Sbjct: 264 IPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWA 309



 Score = 94.4 bits (233), Expect = 1e-19
 Identities = 55/168 (32%), Positives = 86/168 (51%)

Query: 116 LKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDL 175
           + A+ E   +++++ L  G +    D    TAL WAC KG + +V  LL  GA      L
Sbjct: 76  ISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGL 135

Query: 176 LDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAH 235
               P+ WA   GH  I+  LL  GA+VN  DK G+TPL  A R  H +C++HL+  GA 
Sbjct: 136 YSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGAD 195

Query: 236 LNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
           ++ +     TAL  AV+ G  +++K +L     + + +    T + +A
Sbjct: 196 VDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIA 243



 Score = 80.5 bits (197), Expect = 2e-15
 Identities = 51/166 (30%), Positives = 83/166 (50%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLD 177
           AA +    ++ + + +G + N  D  + TAL  A  +GH  +V +LL  G  ++ RD+  
Sbjct: 45  AAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGG 104

Query: 178 RTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLN 237
            T + WAC  G   +++ LL+ GA  +        P+  A    H D +  L++ GA +N
Sbjct: 105 WTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVN 164

Query: 238 AQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
             DK G T L  A R G  + +K LL  GA++    A S+T + +A
Sbjct: 165 CSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVA 210



 Score = 78.2 bits (191), Expect = 9e-15
 Identities = 56/176 (31%), Positives = 85/176 (48%), Gaps = 3/176 (1%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLD 177
           A+ E    ++   L  G   N  D+   T L  A   GH ++V  LL   A +D R   +
Sbjct: 243 ASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDN 302

Query: 178 RTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLN 237
           +T ++WA   G+  +++ +L          K G TPL  A + R+ + +E L++ GA ++
Sbjct: 303 KTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVS 362

Query: 238 AQDKEGDTALHEAVRHGSYKAMKLLLLY---GAELGVRNAASVTPVQLARDWQRGI 290
           A DK+GDT LH A+R  S K  +LLL     G  L   N A  TP  +    Q+ I
Sbjct: 363 AVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSI 418



 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 40/111 (36%), Positives = 57/111 (51%)

Query: 170 VDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHL 229
           VD R+   +TP+  A   G+L I+K+L+  GA  N  D    T L  A +  H   +E L
Sbjct: 31  VDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEEL 90

Query: 230 IECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPV 280
           ++CG +L  +D  G TAL  A   G    ++LLL +GA   V    SV P+
Sbjct: 91  LKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPI 141



 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 34/110 (30%), Positives = 56/110 (50%), Gaps = 1/110 (0%)

Query: 193 LKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVR 252
           LK LL +   V+ R++ G TPL +A    + + ++ LI+ GA+ N +D +  TAL  A +
Sbjct: 21  LKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASK 80

Query: 253 HGSYKAMKLLLLYGAELGVRNAASVTPVQLA-RDWQRGIREALQAHVAHP 301
            G    ++ LL  G  L  R+    T +  A    +  + E L +H A+P
Sbjct: 81  EGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANP 130


>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
          Length = 1076

 Score = 92.4 bits (228), Expect = 4e-19
 Identities = 58/146 (39%), Positives = 76/146 (52%)

Query: 138 NAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLL 197
           N  D+  RT LH A   G   ++  LL++GA V+A+D L  TP+  A    +  +L  LL
Sbjct: 35  NVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLL 94

Query: 198 NQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYK 257
              A VNARDK+  TPLHVA   R   C E L    + LN  D+ G +ALH AV  G  +
Sbjct: 95  AHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLE 154

Query: 258 AMKLLLLYGAELGVRNAASVTPVQLA 283
            + LLL  GA L V +     P+  A
Sbjct: 155 TVNLLLNKGASLNVCDKKERQPLHWA 180



 Score = 87.8 bits (216), Expect = 1e-17
 Identities = 56/167 (33%), Positives = 82/167 (49%)

Query: 117 KAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLL 176
           +AAA   E ++   L    D NA DKL +T LH A     ++    L    ++++  D  
Sbjct: 80  RAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRS 139

Query: 177 DRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHL 236
            R+ +  A   GHL  +  LLN+GA +N  DK    PLH A    H + L+ L+  GA L
Sbjct: 140 GRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADL 199

Query: 237 NAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
             +D++G   LH A   G  + +K LL  GAE+   NA   T + +A
Sbjct: 200 GCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIA 246



 Score = 84.3 bits (207), Expect = 1e-16
 Identities = 61/192 (31%), Positives = 85/192 (44%), Gaps = 36/192 (18%)

Query: 127 IDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVA-------------------- 166
           ++  L  G   N  DK  R  LHWA   GH +++ KLLVA                    
Sbjct: 156 VNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVL-KLLVARGADLGCKDRKGYGLLHTAA 214

Query: 167 --------------GATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGST 212
                         GA +D  +    T +  AC  G   +  +L+N GA VN  +  G T
Sbjct: 215 ASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFT 274

Query: 213 PLHV-AVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGV 271
           PLHV AV T    CLE L+  GA +N Q KEG + LH A  HG +   ++L+  G+E+  
Sbjct: 275 PLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDC 334

Query: 272 RNAASVTPVQLA 283
            +    TP+ +A
Sbjct: 335 ADKFGNTPLHVA 346



 Score = 83.6 bits (205), Expect = 2e-16
 Identities = 50/146 (34%), Positives = 78/146 (53%)

Query: 138 NAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLL 197
           N  D+  R+ALH A   GH + VN LL  GA+++  D  +R P+ WA   GHL +LK L+
Sbjct: 134 NVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLV 193

Query: 198 NQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYK 257
            +GA +  +D+ G   LH A  +   + +++L+  GA ++  +  G+TALH A   G   
Sbjct: 194 ARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDA 253

Query: 258 AMKLLLLYGAELGVRNAASVTPVQLA 283
               L+  GA +   N    TP+ +A
Sbjct: 254 VAIELVNAGANVNQPNDKGFTPLHVA 279



 Score = 77.8 bits (190), Expect = 1e-14
 Identities = 52/188 (27%), Positives = 80/188 (42%), Gaps = 18/188 (9%)

Query: 114 MFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDAR 173
           + + A + N    ++  + +G D N   K  ++ LH A + G       L+  G+ +D  
Sbjct: 276 LHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCA 335

Query: 174 DLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCL------- 226
           D    TP+  A R GH +++  L+  GA    R      PLH+AV     DC        
Sbjct: 336 DKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSG 395

Query: 227 -----------EHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAA 275
                      EH++  G  +N  D  G T LH A   G+ + + LLL  GA+L  R+  
Sbjct: 396 QLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKF 455

Query: 276 SVTPVQLA 283
             TP+  A
Sbjct: 456 GRTPLHYA 463



 Score = 74.3 bits (181), Expect = 1e-13
 Identities = 54/174 (31%), Positives = 85/174 (48%), Gaps = 1/174 (0%)

Query: 111 GLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATV 170
           G  +   AAA  Q  ++   L  G + +  +    TALH AC  G   +  +L+ AGA V
Sbjct: 206 GYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANV 265

Query: 171 DARDLLDRTPVFWACRGGH-LVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHL 229
           +  +    TP+  A    +  + L+ L+N GA VN + K G +PLH+A         + L
Sbjct: 266 NQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQIL 325

Query: 230 IECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
           I+ G+ ++  DK G+T LH A R+G    +  L+  GA+   R    + P+ LA
Sbjct: 326 IQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLA 379



 Score = 72.8 bits (177), Expect = 4e-13
 Identities = 51/171 (29%), Positives = 77/171 (45%), Gaps = 18/171 (10%)

Query: 131 LTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWA------ 184
           + +G + +  DK   T LH A   GH  L++ L+  GA    R + D  P+  A      
Sbjct: 326 IQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFS 385

Query: 185 --CR----GGHLVIL------KQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIEC 232
             CR     G L  +      + +L+ G  +N  D +G T LH A    + +CL  L+  
Sbjct: 386 DCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSS 445

Query: 233 GAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
           GA L  +DK G T LH A  +GSY+    L+  GA +   +    +P+  A
Sbjct: 446 GADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYA 496



 Score = 68.6 bits (166), Expect = 7e-12
 Identities = 51/158 (32%), Positives = 66/158 (41%), Gaps = 18/158 (11%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLV------------ 165
           AA    E LI   +T+G D           LH A L G S    KLL             
Sbjct: 346 AARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLS 405

Query: 166 ------AGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVR 219
                 AG  ++  D L RT +  A  GG++  L  LL+ GA +  RDK G TPLH A  
Sbjct: 406 NEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAA 465

Query: 220 TRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYK 257
                C   L+  GA +N  D +G + LH A    +Y+
Sbjct: 466 NGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYR 503



 Score = 67.0 bits (162), Expect = 2e-11
 Identities = 48/150 (32%), Positives = 72/150 (48%), Gaps = 4/150 (2%)

Query: 138 NAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDR-TPVFWACRGGHLVILKQL 196
           +  D   RTAL  A  +G ++ V  L   GA+   ++   + TP+  A   GH   L  L
Sbjct: 612 DVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLL 671

Query: 197 LNQGARVNARDKI---GSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRH 253
           ++ G R +  D +   G TPL +A+   H DC+  L+E G+  +A D  G TALH     
Sbjct: 672 IDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVT 731

Query: 254 GSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
           G    +  LL + A +  R+    TP+ LA
Sbjct: 732 GCEDCLAALLDHDAFVLCRDFKGRTPIHLA 761



 Score = 62.8 bits (151), Expect = 4e-10
 Identities = 39/121 (32%), Positives = 61/121 (50%), Gaps = 3/121 (2%)

Query: 146 TALHWACLKGHSQLVNKLLVAGATVDARDLLD---RTPVFWACRGGHLVILKQLLNQGAR 202
           T LH A   GH+  ++ L+ +G   D  D++D   +TP+  A   GH+  +  LL +G+ 
Sbjct: 654 TPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGST 713

Query: 203 VNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLL 262
            +A D  G T LH    T   DCL  L++  A +  +D +G T +H A   G    ++ L
Sbjct: 714 ADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTL 773

Query: 263 L 263
           L
Sbjct: 774 L 774



 Score = 62.8 bits (151), Expect = 4e-10
 Identities = 60/175 (34%), Positives = 79/175 (45%), Gaps = 13/175 (7%)

Query: 131 LTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHL 190
           L  G   +A D   RTALH   + G    +  LL   A V  RD   RTP+  A   GH 
Sbjct: 708 LEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHT 767

Query: 191 VILKQLLNQGARVNARDK----IGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGD-- 244
            +L+ LL      +  D      G +P+H A  T H DCLE L+E   H      EG+  
Sbjct: 768 AVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLE---HSPFSYLEGNPF 824

Query: 245 TALHEAVRHGSYKAMKLLL-LYGAEL-GVRNAASVTPVQLA--RDWQRGIREALQ 295
           T LH AV +      ++LL   GA++   R+A   TP+  A   D   G+R  LQ
Sbjct: 825 TPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQ 879



 Score = 60.8 bits (146), Expect = 1e-09
 Identities = 57/197 (28%), Positives = 83/197 (42%), Gaps = 10/197 (5%)

Query: 93  RKPEPLVKPQSQAQVEPVGLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWAC 152
           R+ EP       A+ +    E   K A    E+L+D    +G DP+  D+   TA+H+A 
Sbjct: 503 RRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLD----NGADPSLRDRQGYTAVHYAA 558

Query: 153 LKGHSQLVNKLLVA--GATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIG 210
             G+ Q +  LL        D    +  +P+  A   GH   LK L      ++ RD  G
Sbjct: 559 AYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKG 618

Query: 211 STPLHVAVRTRHPDCLEHLIECGAH-LNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAE- 268
            T L +A      +C+E L   GA  L  + K   T LH A   G   ++ LL+  G   
Sbjct: 619 RTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERA 678

Query: 269 --LGVRNAASVTPVQLA 283
               V +A   TP+ LA
Sbjct: 679 DITDVMDAYGQTPLMLA 695



 Score = 60.8 bits (146), Expect = 1e-09
 Identities = 52/164 (31%), Positives = 74/164 (45%), Gaps = 8/164 (4%)

Query: 146 TALHWACLKGHSQLVNKLLVA--GATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARV 203
           T LH A +         LL A     V++RD   RTP+  A    ++  L+ LL   A V
Sbjct: 825 TPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEV 884

Query: 204 NARDKIGSTPLHVAVRTRHPDCLEHLIECG-AHLNAQDKEGDTALHEAVRHGSYKAMKLL 262
           NA D  G T L  A        +E L+  G A L   D+  +TALH A   G  K   ++
Sbjct: 885 NATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMI 944

Query: 263 LLYGAELGVRNA---ASVTPVQLARDWQRGIREALQAHVAHPRT 303
           L    +LG+ NA   A   P+ +A   + G+   +QA ++H  T
Sbjct: 945 LAETQDLGLINATNSALQMPLHIAA--RNGLASVVQALLSHGAT 986



 Score = 55.1 bits (131), Expect = 8e-08
 Identities = 53/178 (29%), Positives = 73/178 (41%), Gaps = 39/178 (21%)

Query: 145 RTALHWACLKGHSQLVNKLLVAGATVDARDL----LDRTPVFWACRGGHLVILKQLLNQ- 199
           RT +H A   GH+ ++  LL A  + D  D        +P+ WA   GH   L+ LL   
Sbjct: 755 RTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHS 814

Query: 200 --------------------------------GAR-VNARDKIGSTPLHVAVRTRHPDCL 226
                                           GA+ VN+RD  G TPLH A    +   L
Sbjct: 815 PFSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGL 874

Query: 227 EHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYG-AELGVRNAASVTPVQLA 283
             L++  A +NA D  G TAL  A  +G   A++ LL  G A+L V +    T + LA
Sbjct: 875 RMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLA 932



 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 33/109 (30%), Positives = 55/109 (50%)

Query: 175 LLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGA 234
           + D+ P+  A     +  ++ LL+Q   +N  D+   TPLH A        L+ L+  GA
Sbjct: 6   ITDQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGA 65

Query: 235 HLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
           ++NA+D    T LH A    + K + LLL + A++  R+    TP+ +A
Sbjct: 66  NVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVA 114



 Score = 52.0 bits (123), Expect = 7e-07
 Identities = 41/127 (32%), Positives = 56/127 (44%), Gaps = 4/127 (3%)

Query: 141 DKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQG 200
           D   +T L  A + GH   V+ LL  G+T DA DL  RT +      G    L  LL+  
Sbjct: 685 DAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHD 744

Query: 201 ARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLN----AQDKEGDTALHEAVRHGSY 256
           A V  RD  G TP+H+A    H   L  L++     +      D  G + +H A   G  
Sbjct: 745 AFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHE 804

Query: 257 KAMKLLL 263
             ++LLL
Sbjct: 805 DCLELLL 811



 Score = 47.8 bits (112), Expect = 1e-05
 Identities = 43/147 (29%), Positives = 64/147 (43%), Gaps = 6/147 (4%)

Query: 138 NAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLL 197
           N+ D   RT LH A    +   +  LL   A V+A D   RT +  A   G    ++ LL
Sbjct: 852 NSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLL 911

Query: 198 NQG-ARVNARDKIGSTPLHVAVRTRHPDC----LEHLIECGAHLNAQDKEGDTALHEAVR 252
            +G A +   D+  +T LH+A    H  C    L    + G  +NA +      LH A R
Sbjct: 912 YRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGL-INATNSALQMPLHIAAR 970

Query: 253 HGSYKAMKLLLLYGAELGVRNAASVTP 279
           +G    ++ LL +GA +   +    TP
Sbjct: 971 NGLASVVQALLSHGATVLAVDEEGHTP 997



 Score = 46.6 bits (109), Expect = 3e-05
 Identities = 42/133 (31%), Positives = 60/133 (45%), Gaps = 8/133 (6%)

Query: 102  QSQAQV---EPVGLEMFLKAAAENQEYLIDKYLTDG-GDPNAHDKLHRTALHWACLKGHS 157
            Q QA+V   +  G    + AA   Q   ++  L  G  D    D+   TALH AC KGH 
Sbjct: 879  QHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHE 938

Query: 158  QLVNKLLVAG---ATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTP- 213
            +    +L        ++A +   + P+  A R G   +++ LL+ GA V A D+ G TP 
Sbjct: 939  KCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPA 998

Query: 214  LHVAVRTRHPDCL 226
            L  A      DCL
Sbjct: 999  LACAPNKDVADCL 1011


>gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens]
          Length = 1050

 Score = 91.3 bits (225), Expect = 1e-18
 Identities = 57/148 (38%), Positives = 81/148 (54%), Gaps = 1/148 (0%)

Query: 148 LHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARD 207
           LH A L G + L+  LL  GA   AR+     P+  AC+ GH  ++K LL+  A+ N +D
Sbjct: 748 LHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKD 807

Query: 208 KIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGA 267
             G+TPL  A    H + +  L++ GA +NA + +G+TALHEAV       ++LLLL+GA
Sbjct: 808 LSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGA 867

Query: 268 ELGVRNAASVTPVQLARDWQRGIREALQ 295
            + V N    T V  A    + I E LQ
Sbjct: 868 SVQVLNKRQRTAVDCAEQNSK-IMELLQ 894



 Score = 83.2 bits (204), Expect = 3e-16
 Identities = 50/150 (33%), Positives = 78/150 (52%), Gaps = 3/150 (2%)

Query: 137 PNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQL 196
           P + D    T LH A + G + L++ L+  GA V+A D    TP+  AC+ G+  +   L
Sbjct: 456 PFSRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLL 515

Query: 197 LNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIEC---GAHLNAQDKEGDTALHEAVRH 253
           L+  A    +D  G+TPLH+A    H DC++ L+        L+  +++GDT LH A R 
Sbjct: 516 LHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARW 575

Query: 254 GSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
           G    ++ LL  GA   ++N    TP++ A
Sbjct: 576 GYQGVIETLLQNGASTEIQNRLKETPLKCA 605



 Score = 80.1 bits (196), Expect = 2e-15
 Identities = 52/145 (35%), Positives = 76/145 (52%), Gaps = 2/145 (1%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLD 177
           AA   +  LI   L  G +  A +      LH AC +GH Q+V  LL + A  + +DL  
Sbjct: 751 AALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSG 810

Query: 178 RTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLN 237
            TP+ +AC GGH  ++  LL  GA +NA +  G+T LH AV  +H   +E L+  GA + 
Sbjct: 811 NTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQ 870

Query: 238 AQDKEGDTALHEAVRHGSYKAMKLL 262
             +K   TA+  A ++   K M+LL
Sbjct: 871 VLNKRQRTAVDCAEQNS--KIMELL 893



 Score = 70.5 bits (171), Expect = 2e-12
 Identities = 52/167 (31%), Positives = 81/167 (48%), Gaps = 6/167 (3%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLD 177
           AA   Q  LID  ++ G   NA D    T LH AC KG+  +   LL   A+ + +D   
Sbjct: 470 AAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEVQDNNG 529

Query: 178 RTPVFWACRGGHLVILKQLLN---QGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGA 234
            TP+  AC  GH   +K L+    +  R++  ++ G TPLH+A R  +   +E L++ GA
Sbjct: 530 NTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGA 589

Query: 235 HLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQ 281
               Q++  +T L  A+   + K + ++  Y      R  +S  PVQ
Sbjct: 590 STEIQNRLKETPLKCAL---NSKILSVMEAYHLSFERRQKSSEAPVQ 633



 Score = 50.8 bits (120), Expect = 1e-06
 Identities = 32/112 (28%), Positives = 54/112 (48%)

Query: 162 KLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTR 221
           K+  +G  V+       +P+  A   G   ++  LL  GA   AR+   + PLH+A +  
Sbjct: 729 KVPASGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQG 788

Query: 222 HPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRN 273
           H   ++ L++  A  N +D  G+T L  A   G ++ + LLL +GA +   N
Sbjct: 789 HFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASN 840



 Score = 43.9 bits (102), Expect = 2e-04
 Identities = 25/81 (30%), Positives = 43/81 (53%)

Query: 200 GARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAM 259
           G  VN   + GS+PLHVA      D +  L++ GA+  A++ +    LH A + G ++ +
Sbjct: 734 GLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVV 793

Query: 260 KLLLLYGAELGVRNAASVTPV 280
           K LL   A+   ++ +  TP+
Sbjct: 794 KCLLDSNAKPNKKDLSGNTPL 814



 Score = 41.2 bits (95), Expect = 0.001
 Identities = 20/51 (39%), Positives = 27/51 (52%)

Query: 233 GAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
           G  +N   ++G + LH A  HG    + LLL +GA  G RNA    P+ LA
Sbjct: 734 GLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLA 784



 Score = 33.9 bits (76), Expect = 0.18
 Identities = 24/80 (30%), Positives = 38/80 (47%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLD 177
           A +     L+   L  G   NA +    TALH A ++ H  +V  LL+ GA+V   +   
Sbjct: 817 ACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQ 876

Query: 178 RTPVFWACRGGHLVILKQLL 197
           RT V  A +   ++ L Q++
Sbjct: 877 RTAVDCAEQNSKIMELLQVV 896


>gi|34304381 inversin isoform a [Homo sapiens]
          Length = 1065

 Score = 89.4 bits (220), Expect = 4e-18
 Identities = 69/206 (33%), Positives = 92/206 (44%), Gaps = 39/206 (18%)

Query: 97  PLVKPQSQAQVEPVGLEMFLKAAAENQEYLIDKYLT--DGGDPNAHDKLHRTALHWACLK 154
           P VK  S  +    G   F+ AA +  + ++   L+     D N  DK   TALH A L 
Sbjct: 312 PSVKDDSDLE----GRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALS 367

Query: 155 GHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARV----------- 203
           GH   V  LL   A VDA D++  TP+F AC  GH  +++ L+  GARV           
Sbjct: 368 GHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLL 427

Query: 204 ----------------------NARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDK 241
                                 N +D  G TPL  A    + +C+  L+E  A  N QDK
Sbjct: 428 HWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDK 487

Query: 242 EGDTALHEAVRHGSYKAMKLLLLYGA 267
           EG TALH +  +G   A+KLLL + A
Sbjct: 488 EGRTALHWSCNNGYLDAIKLLLDFAA 513



 Score = 68.6 bits (166), Expect = 7e-12
 Identities = 45/145 (31%), Positives = 72/145 (49%), Gaps = 2/145 (1%)

Query: 141 DKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQG 200
           D+  RT L +  L       + LL AGA V+  D   RT +  A + G+   +K LL + 
Sbjct: 45  DQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRR 104

Query: 201 ARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGA--HLNAQDKEGDTALHEAVRHGSYKA 258
           A    +D    TPLH+  R R P CL  L++  A   ++ QDK   TALH +  + + + 
Sbjct: 105 ANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEH 164

Query: 259 MKLLLLYGAELGVRNAASVTPVQLA 283
           +KLL+ + + +G+ +     P+  A
Sbjct: 165 VKLLIKHDSNIGIPDVEGKIPLHWA 189



 Score = 67.0 bits (162), Expect = 2e-11
 Identities = 48/168 (28%), Positives = 78/168 (46%), Gaps = 2/168 (1%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDAR--DL 175
           AA  N    +  +L      +  D   RT+  WA  KG   ++  +L   + +D    D 
Sbjct: 296 AAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADK 355

Query: 176 LDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAH 235
              T +  A   GH+  +K LL   A+V+A D +  TPL  A    H D ++ LI+ GA 
Sbjct: 356 YGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGAR 415

Query: 236 LNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
           ++  D++G + LH A   G+    ++L+       V++ A  TP+Q A
Sbjct: 416 VDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCA 463



 Score = 57.4 bits (137), Expect = 2e-08
 Identities = 47/163 (28%), Positives = 70/163 (42%), Gaps = 13/163 (7%)

Query: 128 DKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRG 187
           D  L  G D N  D   RTALH A  KG+ + +  LL   A    +DL + TP+    R 
Sbjct: 65  DALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRH 124

Query: 188 GH---LVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGD 244
                L +L + +  G  V+ +DK   T LH +    +P+ ++ LI+  +++   D EG 
Sbjct: 125 RSPKCLALLLKFMAPG-EVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGK 183

Query: 245 TALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLARDWQ 287
             LH A  H    A+           VR      P +   +WQ
Sbjct: 184 IPLHWAANHKDPSAVHT---------VRCILDAAPTESLLNWQ 217



 Score = 55.8 bits (133), Expect = 5e-08
 Identities = 32/99 (32%), Positives = 49/99 (49%)

Query: 184 ACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEG 243
           A  G    + + ++   A  +  D+ G TPL   V     DC + L++ GA +N  D   
Sbjct: 22  AVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQ 81

Query: 244 DTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQL 282
            TALH A + G+Y+ MKLLL   A    ++   +TP+ L
Sbjct: 82  RTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHL 120



 Score = 55.1 bits (131), Expect = 8e-08
 Identities = 38/153 (24%), Positives = 72/153 (47%), Gaps = 2/153 (1%)

Query: 117 KAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLL 176
           +A     + +I   +  G   +  D+   + LHWA L G++ +   L+      + +D  
Sbjct: 396 RACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYA 455

Query: 177 DRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHL 236
            RTP+  A  GG++  +  L+   A  N +DK G T LH +    + D ++ L++  A  
Sbjct: 456 GRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFP 515

Query: 237 NAQD--KEGDTALHEAVRHGSYKAMKLLLLYGA 267
           N  +  +E  T L  A+    ++ ++ +L +GA
Sbjct: 516 NQMENNEERYTPLDYALLGERHEVIQFMLEHGA 548



 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 54/195 (27%), Positives = 80/195 (41%), Gaps = 39/195 (20%)

Query: 138 NAHDKLHRTALHWACLKGHSQLVNKLL-VAGATVDARDLLDRTPVFWACRGGHLVILKQL 196
           N  D   RT LH+A   G+  +V+ L       + + D L RTP+ WA   GH  I+  L
Sbjct: 215 NWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLL 274

Query: 197 LNQG-ARVNARDKIGSTPLHVAVRT----------RHP---------------------- 223
           L +  +     D  G+TPLH A ++          +HP                      
Sbjct: 275 LERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGS 334

Query: 224 -DCLEHL--IECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPV 280
            D L  +  ++    +N  DK G TALH A   G    +KLLL   A++   +    TP 
Sbjct: 335 DDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTP- 393

Query: 281 QLARDWQRGIREALQ 295
            L R  + G ++ +Q
Sbjct: 394 -LFRACEMGHKDVIQ 407



 Score = 52.0 bits (123), Expect = 7e-07
 Identities = 37/121 (30%), Positives = 56/121 (46%), Gaps = 1/121 (0%)

Query: 148 LHWACLKGHSQLVNKLLVAGATV-DARDLLDRTPVFWACRGGHLVILKQLLNQGARVNAR 206
           +H A + G    + +L+V  + + D  D   RTP+ +      L     LL  GA VN  
Sbjct: 18  VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77

Query: 207 DKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYG 266
           D    T LH+A +  +   ++ L+   A+   +D E  T LH   RH S K + LLL + 
Sbjct: 78  DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137

Query: 267 A 267
           A
Sbjct: 138 A 138



 Score = 43.9 bits (102), Expect = 2e-04
 Identities = 42/178 (23%), Positives = 74/178 (41%), Gaps = 10/178 (5%)

Query: 135 GDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACR-----GGH 189
           G+ +  DK  +TALHW+    + + V  L+   + +   D+  + P+ WA         H
Sbjct: 140 GEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVH 199

Query: 190 LV-ILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIEC-GAHLNAQDKEGDTAL 247
            V  +       + +N +D  G TPLH AV   +   ++ L      ++ + D    T L
Sbjct: 200 TVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPL 259

Query: 248 HEAVRHGSYKAMKLLLLYGAELGV-RNAASVTPVQLARDWQRGIREALQAHVAHPRTR 304
           H A   G  + + LLL       +  ++   TP+  A   Q    E ++  + HP  +
Sbjct: 260 HWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAA--QSNFAETVKVFLKHPSVK 315


>gi|34304379 inversin isoform b [Homo sapiens]
          Length = 895

 Score = 89.4 bits (220), Expect = 4e-18
 Identities = 69/206 (33%), Positives = 92/206 (44%), Gaps = 39/206 (18%)

Query: 97  PLVKPQSQAQVEPVGLEMFLKAAAENQEYLIDKYLT--DGGDPNAHDKLHRTALHWACLK 154
           P VK  S  +    G   F+ AA +  + ++   L+     D N  DK   TALH A L 
Sbjct: 312 PSVKDDSDLE----GRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALS 367

Query: 155 GHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARV----------- 203
           GH   V  LL   A VDA D++  TP+F AC  GH  +++ L+  GARV           
Sbjct: 368 GHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLL 427

Query: 204 ----------------------NARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDK 241
                                 N +D  G TPL  A    + +C+  L+E  A  N QDK
Sbjct: 428 HWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDK 487

Query: 242 EGDTALHEAVRHGSYKAMKLLLLYGA 267
           EG TALH +  +G   A+KLLL + A
Sbjct: 488 EGRTALHWSCNNGYLDAIKLLLDFAA 513



 Score = 68.6 bits (166), Expect = 7e-12
 Identities = 45/145 (31%), Positives = 72/145 (49%), Gaps = 2/145 (1%)

Query: 141 DKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQG 200
           D+  RT L +  L       + LL AGA V+  D   RT +  A + G+   +K LL + 
Sbjct: 45  DQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRR 104

Query: 201 ARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGA--HLNAQDKEGDTALHEAVRHGSYKA 258
           A    +D    TPLH+  R R P CL  L++  A   ++ QDK   TALH +  + + + 
Sbjct: 105 ANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEH 164

Query: 259 MKLLLLYGAELGVRNAASVTPVQLA 283
           +KLL+ + + +G+ +     P+  A
Sbjct: 165 VKLLIKHDSNIGIPDVEGKIPLHWA 189



 Score = 67.0 bits (162), Expect = 2e-11
 Identities = 48/168 (28%), Positives = 78/168 (46%), Gaps = 2/168 (1%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDAR--DL 175
           AA  N    +  +L      +  D   RT+  WA  KG   ++  +L   + +D    D 
Sbjct: 296 AAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADK 355

Query: 176 LDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAH 235
              T +  A   GH+  +K LL   A+V+A D +  TPL  A    H D ++ LI+ GA 
Sbjct: 356 YGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGAR 415

Query: 236 LNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
           ++  D++G + LH A   G+    ++L+       V++ A  TP+Q A
Sbjct: 416 VDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCA 463



 Score = 57.4 bits (137), Expect = 2e-08
 Identities = 47/163 (28%), Positives = 70/163 (42%), Gaps = 13/163 (7%)

Query: 128 DKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRG 187
           D  L  G D N  D   RTALH A  KG+ + +  LL   A    +DL + TP+    R 
Sbjct: 65  DALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRH 124

Query: 188 GH---LVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGD 244
                L +L + +  G  V+ +DK   T LH +    +P+ ++ LI+  +++   D EG 
Sbjct: 125 RSPKCLALLLKFMAPG-EVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGK 183

Query: 245 TALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLARDWQ 287
             LH A  H    A+           VR      P +   +WQ
Sbjct: 184 IPLHWAANHKDPSAVHT---------VRCILDAAPTESLLNWQ 217



 Score = 55.8 bits (133), Expect = 5e-08
 Identities = 32/99 (32%), Positives = 49/99 (49%)

Query: 184 ACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEG 243
           A  G    + + ++   A  +  D+ G TPL   V     DC + L++ GA +N  D   
Sbjct: 22  AVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQ 81

Query: 244 DTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQL 282
            TALH A + G+Y+ MKLLL   A    ++   +TP+ L
Sbjct: 82  RTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHL 120



 Score = 55.1 bits (131), Expect = 8e-08
 Identities = 38/153 (24%), Positives = 72/153 (47%), Gaps = 2/153 (1%)

Query: 117 KAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLL 176
           +A     + +I   +  G   +  D+   + LHWA L G++ +   L+      + +D  
Sbjct: 396 RACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYA 455

Query: 177 DRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHL 236
            RTP+  A  GG++  +  L+   A  N +DK G T LH +    + D ++ L++  A  
Sbjct: 456 GRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFP 515

Query: 237 NAQD--KEGDTALHEAVRHGSYKAMKLLLLYGA 267
           N  +  +E  T L  A+    ++ ++ +L +GA
Sbjct: 516 NQMENNEERYTPLDYALLGERHEVIQFMLEHGA 548



 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 54/195 (27%), Positives = 80/195 (41%), Gaps = 39/195 (20%)

Query: 138 NAHDKLHRTALHWACLKGHSQLVNKLL-VAGATVDARDLLDRTPVFWACRGGHLVILKQL 196
           N  D   RT LH+A   G+  +V+ L       + + D L RTP+ WA   GH  I+  L
Sbjct: 215 NWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLL 274

Query: 197 LNQG-ARVNARDKIGSTPLHVAVRT----------RHP---------------------- 223
           L +  +     D  G+TPLH A ++          +HP                      
Sbjct: 275 LERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGS 334

Query: 224 -DCLEHL--IECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPV 280
            D L  +  ++    +N  DK G TALH A   G    +KLLL   A++   +    TP 
Sbjct: 335 DDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTP- 393

Query: 281 QLARDWQRGIREALQ 295
            L R  + G ++ +Q
Sbjct: 394 -LFRACEMGHKDVIQ 407



 Score = 52.0 bits (123), Expect = 7e-07
 Identities = 37/121 (30%), Positives = 56/121 (46%), Gaps = 1/121 (0%)

Query: 148 LHWACLKGHSQLVNKLLVAGATV-DARDLLDRTPVFWACRGGHLVILKQLLNQGARVNAR 206
           +H A + G    + +L+V  + + D  D   RTP+ +      L     LL  GA VN  
Sbjct: 18  VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77

Query: 207 DKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYG 266
           D    T LH+A +  +   ++ L+   A+   +D E  T LH   RH S K + LLL + 
Sbjct: 78  DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137

Query: 267 A 267
           A
Sbjct: 138 A 138



 Score = 43.9 bits (102), Expect = 2e-04
 Identities = 42/178 (23%), Positives = 74/178 (41%), Gaps = 10/178 (5%)

Query: 135 GDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACR-----GGH 189
           G+ +  DK  +TALHW+    + + V  L+   + +   D+  + P+ WA         H
Sbjct: 140 GEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVH 199

Query: 190 LV-ILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIEC-GAHLNAQDKEGDTAL 247
            V  +       + +N +D  G TPLH AV   +   ++ L      ++ + D    T L
Sbjct: 200 TVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPL 259

Query: 248 HEAVRHGSYKAMKLLLLYGAELGV-RNAASVTPVQLARDWQRGIREALQAHVAHPRTR 304
           H A   G  + + LLL       +  ++   TP+  A   Q    E ++  + HP  +
Sbjct: 260 HWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAA--QSNFAETVKVFLKHPSVK 315


>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
          Length = 1429

 Score = 88.2 bits (217), Expect = 8e-18
 Identities = 57/162 (35%), Positives = 89/162 (54%), Gaps = 2/162 (1%)

Query: 119  AAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDR 178
            A ENQ  + + +L +G +  A D   RTALH +C +GH ++V  L+   A V+A D   R
Sbjct: 954  ALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKR 1013

Query: 179  TPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNA 238
            + +  A   GH+ +++ L+  GA V+     G+T L +A +  H D ++ L+E GA  N 
Sbjct: 1014 SALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNH 1073

Query: 239  QDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPV 280
             D+ G TA+  A ++G  + +KLL  YGA     N  S +PV
Sbjct: 1074 ADQFGRTAMRVAAKNGHSQIIKLLEKYGA--SSLNGCSPSPV 1113



 Score = 86.3 bits (212), Expect = 3e-17
 Identities = 73/237 (30%), Positives = 110/237 (46%), Gaps = 9/237 (3%)

Query: 56  KKKLERFNSTRFNLDNLADLENLVQRRKKRLRHRVPPRKPEP---LVKPQSQAQVEPV-G 111
           ++ LER +S R  LDN A +       +  L +       +    LV   +  ++E   G
Sbjct: 519 RQALEREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHG 578

Query: 112 LEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVD 171
                 AA +    +++  +  G + N  D+   TAL  A   GH+++V+ LL AG  VD
Sbjct: 579 HTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVD 638

Query: 172 ARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIE 231
             D   RT +  A  GGH  I+  LL  GA VN  D  G T L  A    H + +EHL++
Sbjct: 639 CADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLD 698

Query: 232 CGAHLNAQDKEGDTALHEA-----VRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
            GA +N +D +G TAL  A        G    + LL+  GAE+   +   +TP+ +A
Sbjct: 699 HGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVA 755



 Score = 84.7 bits (208), Expect = 9e-17
 Identities = 64/190 (33%), Positives = 92/190 (48%), Gaps = 1/190 (0%)

Query: 111 GLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATV 170
           G+   L AA E    ++D  L  G D +  D   RT L  A   GH+ +VN LL  GA V
Sbjct: 748 GMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAV 807

Query: 171 DARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLI 230
           D+ D   RT +  A   G++ +++ LL++G   N RD  G TPLH+A    H    E LI
Sbjct: 808 DSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALI 867

Query: 231 ECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLAR-DWQRG 289
           E GA  N  D +G      A + G Y  +++LL   + +  R       +++A  +  R 
Sbjct: 868 EQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRD 927

Query: 290 IREALQAHVA 299
           I E L +H A
Sbjct: 928 IVELLFSHGA 937



 Score = 80.5 bits (197), Expect = 2e-15
 Identities = 63/190 (33%), Positives = 91/190 (47%), Gaps = 6/190 (3%)

Query: 111 GLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACL-----KGHSQLVNKLLV 165
           G    + AA      +++  L  G + N  D   RTAL  A L     KGH+ +V+ L+ 
Sbjct: 677 GRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLID 736

Query: 166 AGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDC 225
            GA VD  D    TP+  A   GH+ ++  LL  GA V+  D  G TPL  A    H   
Sbjct: 737 RGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASV 796

Query: 226 LEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLAR- 284
           +  L+  GA +++ D EG T L  A   G+ + ++ LL  G +   R+ A  TP+ +A  
Sbjct: 797 VNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAF 856

Query: 285 DWQRGIREAL 294
           +  R I EAL
Sbjct: 857 EGHRLICEAL 866



 Score = 68.9 bits (167), Expect = 5e-12
 Identities = 43/123 (34%), Positives = 61/123 (49%)

Query: 145  RTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVN 204
            R AL  A L+GH  +V  L   GA V+ +D   R  ++       L + +  L  GA V 
Sbjct: 914  RNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVE 973

Query: 205  ARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLL 264
            A D  G T LHV+    H + ++ LI   A +NA D E  +AL  A   G  K ++LL+ 
Sbjct: 974  ASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIE 1033

Query: 265  YGA 267
            +GA
Sbjct: 1034 HGA 1036



 Score = 68.6 bits (166), Expect = 7e-12
 Identities = 48/174 (27%), Positives = 78/174 (44%), Gaps = 1/174 (0%)

Query: 118  AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLD 177
            AA E    + +  +  G   N  D   R     A  +GH   V  LL   + +D R    
Sbjct: 854  AAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDG 913

Query: 178  RTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLN 237
            R  +  A   GH  I++ L + GA VN +D  G   L++          E+ +E GA++ 
Sbjct: 914  RNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVE 973

Query: 238  AQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLARDWQRGIR 291
            A D EG TALH +   G  + +++L+ Y A++   +    + +Q A  WQ  ++
Sbjct: 974  ASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAA-WQGHVK 1026



 Score = 65.1 bits (157), Expect = 7e-11
 Identities = 45/151 (29%), Positives = 72/151 (47%)

Query: 118  AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLD 177
            AA E    +++   + G D N  D   R  L+   L+    +    L  GA V+A D   
Sbjct: 920  AALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEG 979

Query: 178  RTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLN 237
            RT +  +C  GH+ +++ L+   A VNA D    + L  A    H   ++ LIE GA ++
Sbjct: 980  RTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVD 1039

Query: 238  AQDKEGDTALHEAVRHGSYKAMKLLLLYGAE 268
                +G TAL  A + G    +++LL +GA+
Sbjct: 1040 HTCNQGATALCIAAQEGHIDVVQVLLEHGAD 1070



 Score = 64.3 bits (155), Expect = 1e-10
 Identities = 51/194 (26%), Positives = 82/194 (42%), Gaps = 2/194 (1%)

Query: 107  VEPVGLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVA 166
            ++  G  +   A+A+    ++   L  G D N  D    T LH A  +GH  +   L+  
Sbjct: 810  IDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQ 869

Query: 167  GATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCL 226
            GA  +  D   R P   A + GH   ++ LL   + ++ R   G   L VA    H D +
Sbjct: 870  GARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIV 929

Query: 227  EHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLARDW 286
            E L   GA +N +D +G   L+           +  L  GA +   +A   T + ++  W
Sbjct: 930  ELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVS-CW 988

Query: 287  QRGIREALQAHVAH 300
            Q G  E +Q  +A+
Sbjct: 989  Q-GHMEMVQVLIAY 1001



 Score = 63.5 bits (153), Expect = 2e-10
 Identities = 46/149 (30%), Positives = 70/149 (46%)

Query: 119 AAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDR 178
           A++    ++   +  G + +  DK   T L  A  +GH  +V+ LL  GA VD  D   R
Sbjct: 723 ASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGR 782

Query: 179 TPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNA 238
           TP+  A   GH  ++  LL  GA V++ D  G T L +A    + + +  L++ G   N 
Sbjct: 783 TPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENH 842

Query: 239 QDKEGDTALHEAVRHGSYKAMKLLLLYGA 267
           +D  G T LH A   G     + L+  GA
Sbjct: 843 RDDAGWTPLHMAAFEGHRLICEALIEQGA 871



 Score = 37.0 bits (84), Expect = 0.022
 Identities = 20/52 (38%), Positives = 27/52 (51%)

Query: 118  AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGAT 169
            AA E    ++   L  G DPN  D+  RTA+  A   GHSQ++  L   GA+
Sbjct: 1052 AAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGAS 1103


>gi|222537750 ankyrin repeat domain 30B [Homo sapiens]
          Length = 1392

 Score = 87.4 bits (215), Expect = 1e-17
 Identities = 52/138 (37%), Positives = 76/138 (55%), Gaps = 2/138 (1%)

Query: 148 LHWACLKGHSQLVNKLLVAGATVDA--RDLLDRTPVFWACRGGHLVILKQLLNQGARVNA 205
           +H A  +G  Q + K+ V    V+   RD+  RT + WAC  GH  ++  L+++  ++N 
Sbjct: 42  IHTAASRGQVQKLEKMTVGKKPVNLNKRDMKKRTALHWACVNGHAEVVTFLVDRKCQLNV 101

Query: 206 RDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLY 265
            D  G TPL  A++     C   LI+ GA LN  D  G+TALH AV   +   +  LL Y
Sbjct: 102 LDGEGRTPLMKALQCEREACANILIDAGADLNYVDVYGNTALHYAVYSENLLMVATLLSY 161

Query: 266 GAELGVRNAASVTPVQLA 283
           GA + V+N AS+TP+ LA
Sbjct: 162 GAVIEVQNKASLTPLLLA 179



 Score = 68.9 bits (167), Expect = 5e-12
 Identities = 54/202 (26%), Positives = 93/202 (46%), Gaps = 37/202 (18%)

Query: 118 AAAENQEYLIDKYLTDGGDP---NAHDKLHRTALHWACLKGHSQLV-------------- 160
           AA+  Q   ++K +T G  P   N  D   RTALHWAC+ GH+++V              
Sbjct: 45  AASRGQVQKLEK-MTVGKKPVNLNKRDMKKRTALHWACVNGHAEVVTFLVDRKCQLNVLD 103

Query: 161 -------------------NKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGA 201
                              N L+ AGA ++  D+   T + +A    +L+++  LL+ GA
Sbjct: 104 GEGRTPLMKALQCEREACANILIDAGADLNYVDVYGNTALHYAVYSENLLMVATLLSYGA 163

Query: 202 RVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKL 261
            +  ++K   TPL +A++ R    +E L+   A+ NA ++   TAL  A+  GS + + +
Sbjct: 164 VIEVQNKASLTPLLLAIQKRSKQTVEFLLTKNANANAFNESKCTALMLAICEGSSEIVGM 223

Query: 262 LLLYGAELGVRNAASVTPVQLA 283
           LL    ++   +   +T  + A
Sbjct: 224 LLQQNVDVFAEDIHGITAERYA 245



 Score = 44.3 bits (103), Expect = 1e-04
 Identities = 37/144 (25%), Positives = 63/144 (43%)

Query: 111 GLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATV 170
           G    +KA    +E   +  +  G D N  D    TALH+A    +  +V  LL  GA +
Sbjct: 106 GRTPLMKALQCEREACANILIDAGADLNYVDVYGNTALHYAVYSENLLMVATLLSYGAVI 165

Query: 171 DARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLI 230
           + ++    TP+  A +      ++ LL + A  NA ++   T L +A+     + +  L+
Sbjct: 166 EVQNKASLTPLLLAIQKRSKQTVEFLLTKNANANAFNESKCTALMLAICEGSSEIVGMLL 225

Query: 231 ECGAHLNAQDKEGDTALHEAVRHG 254
           +    + A+D  G TA   A   G
Sbjct: 226 QQNVDVFAEDIHGITAERYAAACG 249


>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
           sapiens]
          Length = 765

 Score = 87.4 bits (215), Expect = 1e-17
 Identities = 64/183 (34%), Positives = 101/183 (55%), Gaps = 4/183 (2%)

Query: 116 LKAAAENQEYLIDKYLTDGGDPNAHDKLHR--TALHWACLKGHSQLVNKLLVAGATVDAR 173
           L  AA   +YLI K L   G  +     H+  T LH A  KGH ++++ L  + A + A 
Sbjct: 564 LHTAAARGKYLICKMLLRYG-ASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGAL 622

Query: 174 DLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECG 233
             ++ TP+  A R G   ++  LL  GA  NA ++ G TPLH+AV+      + +L+E  
Sbjct: 623 GAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHH 682

Query: 234 AHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA-RDWQRGIRE 292
           A+++A++K G T  H A   G+   +K+L+  GA+L V++  S TP+QLA R  ++GI  
Sbjct: 683 ANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMS 742

Query: 293 ALQ 295
            L+
Sbjct: 743 FLE 745



 Score = 81.3 bits (199), Expect = 1e-15
 Identities = 77/261 (29%), Positives = 108/261 (41%), Gaps = 52/261 (19%)

Query: 72  LADLENLVQRRKKRLRHRVPPRKPEPLVKPQSQAQVEPV----------------GLEMF 115
           L+D +NLV R ++   +     K  PL    +Q  VE V                G    
Sbjct: 343 LSDRKNLVPRDEELCIYE---NKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPL 399

Query: 116 LKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARD- 174
           L AA + Q  L    L  G D N  D+     LH+A   G       LL  GA VDA++ 
Sbjct: 400 LIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQER 459

Query: 175 --------------------LLDR------------TPVFWACRGGHLVILKQLLNQGAR 202
                               L+ R            TP+  A   GH+ ++K L +QGA 
Sbjct: 460 EGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAE 519

Query: 203 VNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLL 262
           ++A+ +   TPLH+AV       ++HL++ GA  +A D+ G   LH A   G Y   K+L
Sbjct: 520 LDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKML 579

Query: 263 LLYGAELGVRNAASVTPVQLA 283
           L YGA L +      TP+ LA
Sbjct: 580 LRYGASLELPTHQGWTPLHLA 600



 Score = 79.3 bits (194), Expect = 4e-15
 Identities = 61/185 (32%), Positives = 84/185 (45%), Gaps = 1/185 (0%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLD 177
           AA  N E +    ++   DPN H+   +T LH A   GH  LV  L   GA +DA+    
Sbjct: 468 AAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNL 527

Query: 178 RTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLN 237
           RTP+  A   G +  ++ LL  GA  +A D+ G  PLH A         + L+  GA L 
Sbjct: 528 RTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLE 587

Query: 238 AQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQL-ARDWQRGIREALQA 296
               +G T LH A   G  + + LL    A +G   A + TP+ L AR  +  +  AL  
Sbjct: 588 LPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQ 647

Query: 297 HVAHP 301
             A P
Sbjct: 648 CGADP 652



 Score = 76.6 bits (187), Expect = 2e-14
 Identities = 51/157 (32%), Positives = 75/157 (47%)

Query: 127 IDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACR 186
           I   L  G  P+A D+     LH A  +G   +   LL  GA+++       TP+  A  
Sbjct: 543 IQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAY 602

Query: 187 GGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTA 246
            GHL I+  L    A + A   +  TPLH+A R      +  L++CGA  NA ++ G T 
Sbjct: 603 KGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTP 662

Query: 247 LHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
           LH AV+  ++ ++  LL + A +  RN    TP  LA
Sbjct: 663 LHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLA 699



 Score = 75.5 bits (184), Expect = 6e-14
 Identities = 51/158 (32%), Positives = 72/158 (45%)

Query: 126 LIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWAC 185
           L+    + G + +A  +  RT LH A  +G  + +  LL +GA  DA D     P+  A 
Sbjct: 509 LVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAA 568

Query: 186 RGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDT 245
             G  +I K LL  GA +      G TPLH+A    H + +  L E  A++ A      T
Sbjct: 569 ARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWT 628

Query: 246 ALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
            LH A RHG    +  LL  GA+      +  TP+ LA
Sbjct: 629 PLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLA 666



 Score = 30.8 bits (68), Expect = 1.6
 Identities = 19/56 (33%), Positives = 31/56 (55%), Gaps = 1/56 (1%)

Query: 245 TALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQL-ARDWQRGIREALQAHVA 299
           T LH  V  GS + ++LLL +  ++  + A+  TP+ + A+D Q  +   L AH A
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419


>gi|70995241 ankyrin repeat domain 10 [Homo sapiens]
          Length = 420

 Score = 87.0 bits (214), Expect = 2e-17
 Identities = 56/155 (36%), Positives = 81/155 (52%), Gaps = 6/155 (3%)

Query: 145 RTALHWACLKGHSQLVNKLL--VAGATVDARD-LLDRTPVFWACRGGHLVILKQLLNQGA 201
           R  LH AC  G    +  LL     A + + D     TPV WA   G L  L QL+  GA
Sbjct: 23  RFPLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGA 82

Query: 202 RVN-ARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMK 260
            +N +  +   TP H+A    HP CL  LI+ GA++N  D EG+T +H+A R GS + + 
Sbjct: 83  TLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECIS 142

Query: 261 LLLLYGAELGVRNAASVTPVQLARDWQRGIREALQ 295
            L+  GA + +RNA+ +T   +A+   +G +E  Q
Sbjct: 143 ALVANGAHVDLRNASGLTAADIAQ--TQGFQECAQ 175



 Score = 65.5 bits (158), Expect = 6e-11
 Identities = 40/119 (33%), Positives = 61/119 (51%), Gaps = 1/119 (0%)

Query: 146 TALHWACLKGHSQLVNKLLVAGATVDARDL-LDRTPVFWACRGGHLVILKQLLNQGARVN 204
           T +HWA   G  + + +L+ AGAT++       +TP   A  GGH   L  L+  GA +N
Sbjct: 60  TPVHWAAHFGKLECLVQLVRAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANIN 119

Query: 205 ARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLL 263
             D  G TP+H A R+   +C+  L+  GAH++ ++  G TA   A   G  +  + LL
Sbjct: 120 KPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178



 Score = 49.7 bits (117), Expect = 3e-06
 Identities = 30/94 (31%), Positives = 44/94 (46%), Gaps = 1/94 (1%)

Query: 145 RTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVN 204
           +T  H A   GH Q +  L+ AGA ++  D    TP+  A R G L  +  L+  GA V+
Sbjct: 93  QTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVD 152

Query: 205 ARDKIGSTPLHVAVRTRHPDCLEHLIEC-GAHLN 237
            R+  G T   +A      +C + L+     HLN
Sbjct: 153 LRNASGLTAADIAQTQGFQECAQFLLNLQNCHLN 186


>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
          Length = 1430

 Score = 85.9 bits (211), Expect = 4e-17
 Identities = 49/146 (33%), Positives = 72/146 (49%), Gaps = 2/146 (1%)

Query: 155 GHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPL 214
           G+ Q++  L+  G+ +D +D      V+WA R GH+  LK L      ++ +DK G   L
Sbjct: 390 GNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMAL 449

Query: 215 HVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNA 274
           HVA R  H D  + L   G++ N QDKE +T LH A  HG Y   K L   G  + ++N 
Sbjct: 450 HVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNR 509

Query: 275 ASVTPVQLARDWQRGIREALQAHVAH 300
              TP+  A    RG  + ++    H
Sbjct: 510 EGETPLLTAS--ARGYHDIVECLAEH 533



 Score = 84.3 bits (207), Expect = 1e-16
 Identities = 60/187 (32%), Positives = 91/187 (48%), Gaps = 1/187 (0%)

Query: 98  LVKPQSQAQVEPVGLEMFLKAAAENQEYLIDKYLTDGGDP-NAHDKLHRTALHWACLKGH 156
           L+K  S+  V+  G    +  AA +      K+L++   P +  DK    ALH A   GH
Sbjct: 398 LIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGH 457

Query: 157 SQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHV 216
           + +   L   G+  + +D  + TP+  A   G+  + K L   G  VN +++ G TPL  
Sbjct: 458 ADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLT 517

Query: 217 AVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAAS 276
           A    + D +E L E GA LNA DK+G  ALH AVR    + +K LL  G  +  ++   
Sbjct: 518 ASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHG 577

Query: 277 VTPVQLA 283
            TP+ +A
Sbjct: 578 NTPLHVA 584



 Score = 82.0 bits (201), Expect = 6e-16
 Identities = 55/172 (31%), Positives = 82/172 (47%), Gaps = 1/172 (0%)

Query: 113 EMFLKAAAENQEYLIDKYLTD-GGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVD 171
           EM L  AA      + + L   G +PN  DK   T LH A   G+  +   L  AG  V+
Sbjct: 446 EMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVN 505

Query: 172 ARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIE 231
            ++    TP+  A   G+  I++ L   GA +NA DK G   LH+AVR    + ++ L+ 
Sbjct: 506 IKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLS 565

Query: 232 CGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
            G  ++ QD+ G+T LH A + G+   +  L      L + N    TP+ LA
Sbjct: 566 QGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLA 617



 Score = 72.0 bits (175), Expect = 6e-13
 Identities = 53/173 (30%), Positives = 83/173 (47%), Gaps = 1/173 (0%)

Query: 116 LKAAAENQEYLIDKYLTDGG-DPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARD 174
           L  AA +  Y + K L + G + N  ++   T L  A  +G+  +V  L   GA ++A D
Sbjct: 482 LHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACD 541

Query: 175 LLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGA 234
                 +  A R   + ++K LL+QG  V+ +D+ G+TPLHVA +  +   +  L E   
Sbjct: 542 KDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANC 601

Query: 235 HLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLARDWQ 287
           +L+  +K G T LH A  +G    ++ L L GA +        T   LAR  Q
Sbjct: 602 NLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQ 654



 Score = 65.5 bits (158), Expect = 6e-11
 Identities = 35/104 (33%), Positives = 59/104 (56%)

Query: 180 PVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQ 239
           P+  A   G++ IL+ L+ +G+R++ +DK GS  ++ A R  H D L+ L E    L+ +
Sbjct: 382 PLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVK 441

Query: 240 DKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
           DK G+ ALH A R+G     +LL  +G+   +++    TP+  A
Sbjct: 442 DKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCA 485



 Score = 44.3 bits (103), Expect = 1e-04
 Identities = 32/117 (27%), Positives = 55/117 (47%), Gaps = 2/117 (1%)

Query: 169 TVDARDLLDRTPVFWACRGGHLVILKQLLNQGAR--VNARDKIGSTPLHVAVRTRHPDCL 226
           T+D  D      +  A    ++  L+ LL   +   VN  +K G+ PL +A    +   L
Sbjct: 336 TLDEEDSFVMKAIIHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQIL 395

Query: 227 EHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
           + LI+ G+ ++ QDK G  A++ A RHG    +K L      L V++ +    + +A
Sbjct: 396 QLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVA 452



 Score = 43.1 bits (100), Expect = 3e-04
 Identities = 35/121 (28%), Positives = 50/121 (41%), Gaps = 4/121 (3%)

Query: 123 QEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVF 182
           Q  +I   L+ G   +  D+   T LH AC  G+  +V  L  A   +D  +   RTP+ 
Sbjct: 556 QMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLH 615

Query: 183 WACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKE 242
            A   G L +++ L   GA V A    G T   +A   +H    EH+    A L      
Sbjct: 616 LAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQH----EHVAGLLARLRKDTHR 671

Query: 243 G 243
           G
Sbjct: 672 G 672


>gi|55742857 ankyrin repeat domain 6 [Homo sapiens]
          Length = 722

 Score = 85.1 bits (209), Expect = 7e-17
 Identities = 55/168 (32%), Positives = 82/168 (48%)

Query: 117 KAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLL 176
           +A       +I   + +G   +  DK   TALH A   G SQ    L+ AGA V A++  
Sbjct: 81  RATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGANVLAKNKA 140

Query: 177 DRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHL 236
             T +  AC+  H    + LL  G+R + ++  G T LHVA R  H   +  L+     +
Sbjct: 141 GNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSV 200

Query: 237 NAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLAR 284
           + +++ GDTALH A      K  K+LL  GA+  + N A  TP++ AR
Sbjct: 201 HEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETAR 248



 Score = 82.4 bits (202), Expect = 5e-16
 Identities = 57/167 (34%), Positives = 91/167 (54%), Gaps = 5/167 (2%)

Query: 117 KAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLL 176
           K   EN   LI+K     G   A  K  RT LH A  KGH  +V  LL AG  +D +D  
Sbjct: 20  KGQTENVVQLINK-----GARVAVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQDDG 74

Query: 177 DRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHL 236
           D+T +  A   G+  I+  L+++G  ++ +DK G+T LH A         + L++ GA++
Sbjct: 75  DQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGANV 134

Query: 237 NAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
            A++K G+TALH A ++   ++ ++LLL G+   ++N A  T + +A
Sbjct: 135 LAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVA 181



 Score = 73.9 bits (180), Expect = 2e-13
 Identities = 48/166 (28%), Positives = 81/166 (48%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLD 177
           AA +    ++   L  G D +  D   +TALH A + G+++++  L+  G  +D +D   
Sbjct: 49  AANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDG 108

Query: 178 RTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLN 237
            T +  A   G     K L+  GA V A++K G+T LH+A +  H      L+  G+  +
Sbjct: 109 NTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRAD 168

Query: 238 AQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
            ++  GDT LH A R+     ++LLL     +  +N A  T + +A
Sbjct: 169 LKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVA 214



 Score = 70.9 bits (172), Expect = 1e-12
 Identities = 44/129 (34%), Positives = 62/129 (48%)

Query: 134 GGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVIL 193
           G +  A +K   TALH AC   HSQ    LL+AG+  D ++    T +  A R  HL I+
Sbjct: 131 GANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSII 190

Query: 194 KQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRH 253
           + LL     V+ +++ G T LHVA    H    + L+E GA     +  G T L  A  H
Sbjct: 191 RLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYH 250

Query: 254 GSYKAMKLL 262
            + +   LL
Sbjct: 251 NNPEVALLL 259


>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
          Length = 1863

 Score = 84.3 bits (207), Expect = 1e-16
 Identities = 50/149 (33%), Positives = 84/149 (56%)

Query: 115 FLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARD 174
           FL+AA       + +YL  G D N  ++    ALH A  +GH  LV +LL  G++VD+  
Sbjct: 14  FLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSAT 73

Query: 175 LLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGA 234
               T +  A   G   ++K L+ +GA +NA+ + G TPL++A +  H D +++L+E GA
Sbjct: 74  KKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGA 133

Query: 235 HLNAQDKEGDTALHEAVRHGSYKAMKLLL 263
           + +   ++G T L  A++ G  +A+ +LL
Sbjct: 134 NQSTATEDGFTPLAVALQQGHNQAVAILL 162



 Score = 84.0 bits (206), Expect = 2e-16
 Identities = 50/138 (36%), Positives = 76/138 (55%)

Query: 146 TALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNA 205
           T LH A  +G++ +V  LL  G  +DA+     TP+  A R GH  +++ LL +GA + A
Sbjct: 247 TPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLA 306

Query: 206 RDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLY 265
           R K G +PLH+A +  H +C++HL++  A ++    +  TALH A   G Y+  KLLL  
Sbjct: 307 RTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDK 366

Query: 266 GAELGVRNAASVTPVQLA 283
            A    R     TP+ +A
Sbjct: 367 RANPNARALNGFTPLHIA 384



 Score = 82.4 bits (202), Expect = 5e-16
 Identities = 54/157 (34%), Positives = 83/157 (52%), Gaps = 1/157 (0%)

Query: 146 TALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNA 205
           TALH A   GH ++   LL   A  +AR L   TP+  AC+   + +++ L+  GA + A
Sbjct: 346 TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQA 405

Query: 206 RDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLY 265
             + G TP+HVA    H + +  L++ GA  +  +  G+TALH A R G  + ++ LL  
Sbjct: 406 ITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRN 465

Query: 266 GAELGVRNAASVTPVQLA-RDWQRGIREALQAHVAHP 301
           GA +  R     TP+ +A R  +  I + L  H+AHP
Sbjct: 466 GALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHP 502



 Score = 82.4 bits (202), Expect = 5e-16
 Identities = 64/189 (33%), Positives = 89/189 (47%), Gaps = 1/189 (0%)

Query: 96  EPLVKPQSQAQ-VEPVGLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLK 154
           E LVK  +  Q +   GL     AA      ++   L +G  P+  +    TALH A   
Sbjct: 394 ELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARA 453

Query: 155 GHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPL 214
           G  ++V  LL  GA VDAR   ++TP+  A R G   I++ LL   A  +A    G TPL
Sbjct: 454 GQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPL 513

Query: 215 HVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNA 274
           H++ R    D    L+E GA  +   K+G T LH A ++GS    KLLL   A       
Sbjct: 514 HISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGK 573

Query: 275 ASVTPVQLA 283
             +TP+ +A
Sbjct: 574 NGLTPLHVA 582



 Score = 79.0 bits (193), Expect = 5e-15
 Identities = 66/204 (32%), Positives = 98/204 (48%), Gaps = 5/204 (2%)

Query: 102 QSQAQVEPVGLEMF--LKAAAENQEYLIDKYLTDG-GDPNAHDKLHRTALHWACLKGHSQ 158
           Q +A V+ V L+    L  AA    Y + K L D   +PNA      T LH AC K   +
Sbjct: 332 QHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIK 391

Query: 159 LVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAV 218
           ++  L+  GA++ A      TP+  A   GHL I+  LL  GA  +  +  G T LH+A 
Sbjct: 392 VMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAA 451

Query: 219 RTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVT 278
           R    + +  L+  GA ++A+ +E  T LH A R G  + ++LLL + A          T
Sbjct: 452 RAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYT 511

Query: 279 PVQL-ARDWQRGIREA-LQAHVAH 300
           P+ + AR+ Q  +    L+A  AH
Sbjct: 512 PLHISAREGQVDVASVLLEAGAAH 535



 Score = 76.6 bits (187), Expect = 2e-14
 Identities = 53/166 (31%), Positives = 79/166 (47%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLD 177
           A+      ++   L  GG  +A  +   T LH A   GH Q+V  LL  GA + AR    
Sbjct: 252 ASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNG 311

Query: 178 RTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLN 237
            +P+  A +G H+  +K LL   A V+       T LHVA    H    + L++  A+ N
Sbjct: 312 LSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPN 371

Query: 238 AQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
           A+   G T LH A +    K M+LL+ YGA +     + +TP+ +A
Sbjct: 372 ARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVA 417



 Score = 75.9 bits (185), Expect = 4e-14
 Identities = 49/166 (29%), Positives = 80/166 (48%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLD 177
           A  +N+  +++  +  G    A  +   T +H A   GH  +V  LL  GA+ D  ++  
Sbjct: 384 ACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRG 443

Query: 178 RTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLN 237
            T +  A R G + +++ LL  GA V+AR +   TPLH+A R    + ++ L++  AH +
Sbjct: 444 ETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPD 503

Query: 238 AQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
           A    G T LH + R G      +LL  GA   +      TP+ +A
Sbjct: 504 AATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVA 549



 Score = 75.9 bits (185), Expect = 4e-14
 Identities = 51/167 (30%), Positives = 80/167 (47%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLD 177
           AA +NQ  +    L  G + N   K   T LH A  +GH+ +V  LL  GA +       
Sbjct: 615 AAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSG 674

Query: 178 RTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLN 237
            T +  A +   + +   L   GA  +A  K+G TPL VA    +   +  L++ GA++N
Sbjct: 675 LTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVN 734

Query: 238 AQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLAR 284
           A+ K G T LH+A + G    + +LL +GA+     A   T + +A+
Sbjct: 735 AKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAK 781



 Score = 72.0 bits (175), Expect = 6e-13
 Identities = 54/172 (31%), Positives = 79/172 (45%), Gaps = 1/172 (0%)

Query: 131 LTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHL 190
           L  G  P+A  K   T LH A  K   Q+ + LL  GA  +       TP+  A + GH 
Sbjct: 595 LEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHT 654

Query: 191 VILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEA 250
            ++  LL++GA ++   K G T LH+A +    +  + L + GA  +A  K G T L  A
Sbjct: 655 DMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVA 714

Query: 251 VRHGSYKAMKLLLLYGAELGVRNAASVTPV-QLARDWQRGIREALQAHVAHP 301
             +G+ K +  LL  GA +  +     TP+ Q A+     I   L  H A P
Sbjct: 715 CHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKP 766



 Score = 70.1 bits (170), Expect = 2e-12
 Identities = 50/147 (34%), Positives = 68/147 (46%)

Query: 137 PNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQL 196
           P+A      T LH +  +G   + + LL AGA          TP+  A + G L + K L
Sbjct: 502 PDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLL 561

Query: 197 LNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSY 256
           L + A  ++  K G TPLHVA    +      L+E GA  +A  K G T LH A +    
Sbjct: 562 LQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQM 621

Query: 257 KAMKLLLLYGAELGVRNAASVTPVQLA 283
           +    LL YGAE  +     VTP+ LA
Sbjct: 622 QIASTLLNYGAETNIVTKQGVTPLHLA 648



 Score = 69.7 bits (169), Expect = 3e-12
 Identities = 55/173 (31%), Positives = 76/173 (43%)

Query: 111 GLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATV 170
           GL     AA    + +++  L  G    A  K   + LH A    H + V  LL   A V
Sbjct: 278 GLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPV 337

Query: 171 DARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLI 230
           D   L   T +  A   GH  + K LL++ A  NAR   G TPLH+A +      +E L+
Sbjct: 338 DDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLV 397

Query: 231 ECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
           + GA + A  + G T +H A   G    + LLL  GA   V N    T + +A
Sbjct: 398 KYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMA 450



 Score = 69.3 bits (168), Expect = 4e-12
 Identities = 49/153 (32%), Positives = 75/153 (49%), Gaps = 4/153 (2%)

Query: 111 GLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATV 170
           GL     AA E    L+ + L  G   ++  K   TALH A L G +++V  L+  GA +
Sbjct: 43  GLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI 102

Query: 171 DARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLI 230
           +A+     TP++ A +  H+ ++K LL  GA  +   + G TPL VA++  H   +  L+
Sbjct: 103 NAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL 162

Query: 231 ECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLL 263
           E     + + K    ALH A R    K+  LLL
Sbjct: 163 E----NDTKGKVRLPALHIAARKDDTKSAALLL 191



 Score = 68.9 bits (167), Expect = 5e-12
 Identities = 44/122 (36%), Positives = 67/122 (54%)

Query: 146 TALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNA 205
           T LH A   G+  +   LL  GA VD       TP+  A + G+  ++K LL++G +++A
Sbjct: 214 TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 273

Query: 206 RDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLY 265
           + + G TPLH A R+ H   +E L+E GA L A+ K G + LH A +    + +K LL +
Sbjct: 274 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH 333

Query: 266 GA 267
            A
Sbjct: 334 KA 335



 Score = 66.2 bits (160), Expect = 3e-11
 Identities = 43/138 (31%), Positives = 65/138 (47%)

Query: 146 TALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNA 205
           T LH A    + ++   LL  GA+  A      TP+  A +   + I   LLN GA  N 
Sbjct: 577 TPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI 636

Query: 206 RDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLY 265
             K G TPLH+A +  H D +  L++ GA+++   K G T+LH A +        +L  +
Sbjct: 637 VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKH 696

Query: 266 GAELGVRNAASVTPVQLA 283
           GA+         TP+ +A
Sbjct: 697 GADQDAHTKLGYTPLIVA 714



 Score = 65.9 bits (159), Expect = 4e-11
 Identities = 47/150 (31%), Positives = 81/150 (54%), Gaps = 8/150 (5%)

Query: 142 KLHRTALHWACLKGHSQLVNKLLVA--GATVDARDLLDRT------PVFWACRGGHLVIL 193
           K+   ALH A  K  ++    LL     A V ++ +++RT      P+  A   G++ + 
Sbjct: 169 KVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVA 228

Query: 194 KQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRH 253
             LLN+GA V+   + G TPLHVA +  + + ++ L++ G  ++A+ ++G T LH A R 
Sbjct: 229 TLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARS 288

Query: 254 GSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
           G  + ++LLL  GA L  R    ++P+ +A
Sbjct: 289 GHDQVVELLLERGAPLLARTKNGLSPLHMA 318



 Score = 64.7 bits (156), Expect = 1e-10
 Identities = 51/166 (30%), Positives = 75/166 (45%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLD 177
           AA   Q  ++   L +G   +A  +  +T LH A   G +++V  LL   A  DA     
Sbjct: 450 AARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNG 509

Query: 178 RTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLN 237
            TP+  + R G + +   LL  GA  +   K G TPLHVA +    D  + L++  A  +
Sbjct: 510 YTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAAD 569

Query: 238 AQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
           +  K G T LH A  + + K   LLL  GA          TP+ +A
Sbjct: 570 SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIA 615



 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 42/109 (38%), Positives = 57/109 (52%)

Query: 111 GLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATV 170
           GL     AA E++  + D     G D +AH KL  T L  AC  G+ ++VN LL  GA V
Sbjct: 674 GLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANV 733

Query: 171 DARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVR 219
           +A+     TP+  A + GH  I+  LL  GA+ NA    G+T L +A R
Sbjct: 734 NAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKR 782



 Score = 62.0 bits (149), Expect = 6e-10
 Identities = 49/166 (29%), Positives = 70/166 (42%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLD 177
           +A E Q  +    L  G   +   K   T LH A   G   +   LL   A  D+     
Sbjct: 516 SAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNG 575

Query: 178 RTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLN 237
            TP+  A    +  +   LL +GA  +A  K G TPLH+A +         L+  GA  N
Sbjct: 576 LTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETN 635

Query: 238 AQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
              K+G T LH A + G    + LLL  GA + +   + +T + LA
Sbjct: 636 IVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLA 681



 Score = 59.7 bits (143), Expect = 3e-09
 Identities = 39/144 (27%), Positives = 73/144 (50%), Gaps = 2/144 (1%)

Query: 151 ACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIG 210
           A   G+   V + L  G  ++  +      +  A + GH+ ++++LL +G+ V++  K G
Sbjct: 17  AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 76

Query: 211 STPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELG 270
           +T LH+A      + ++ L++ GA++NAQ + G T L+ A +      +K LL  GA   
Sbjct: 77  NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 136

Query: 271 VRNAASVTPVQLARDWQRGIREAL 294
                  TP+ +A   Q+G  +A+
Sbjct: 137 TATEDGFTPLAVA--LQQGHNQAV 158


>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
          Length = 1872

 Score = 84.3 bits (207), Expect = 1e-16
 Identities = 50/149 (33%), Positives = 84/149 (56%)

Query: 115 FLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARD 174
           FL+AA       + +YL  G D N  ++    ALH A  +GH  LV +LL  G++VD+  
Sbjct: 35  FLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSAT 94

Query: 175 LLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGA 234
               T +  A   G   ++K L+ +GA +NA+ + G TPL++A +  H D +++L+E GA
Sbjct: 95  KKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGA 154

Query: 235 HLNAQDKEGDTALHEAVRHGSYKAMKLLL 263
           + +   ++G T L  A++ G  +A+ +LL
Sbjct: 155 NQSTATEDGFTPLAVALQQGHNQAVAILL 183



 Score = 84.0 bits (206), Expect = 2e-16
 Identities = 50/138 (36%), Positives = 76/138 (55%)

Query: 146 TALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNA 205
           T LH A  +G++ +V  LL  G  +DA+     TP+  A R GH  +++ LL +GA + A
Sbjct: 268 TPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLA 327

Query: 206 RDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLY 265
           R K G +PLH+A +  H +C++HL++  A ++    +  TALH A   G Y+  KLLL  
Sbjct: 328 RTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDK 387

Query: 266 GAELGVRNAASVTPVQLA 283
            A    R     TP+ +A
Sbjct: 388 RANPNARALNGFTPLHIA 405



 Score = 82.4 bits (202), Expect = 5e-16
 Identities = 54/157 (34%), Positives = 83/157 (52%), Gaps = 1/157 (0%)

Query: 146 TALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNA 205
           TALH A   GH ++   LL   A  +AR L   TP+  AC+   + +++ L+  GA + A
Sbjct: 367 TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQA 426

Query: 206 RDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLY 265
             + G TP+HVA    H + +  L++ GA  +  +  G+TALH A R G  + ++ LL  
Sbjct: 427 ITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRN 486

Query: 266 GAELGVRNAASVTPVQLA-RDWQRGIREALQAHVAHP 301
           GA +  R     TP+ +A R  +  I + L  H+AHP
Sbjct: 487 GALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHP 523



 Score = 82.4 bits (202), Expect = 5e-16
 Identities = 64/189 (33%), Positives = 89/189 (47%), Gaps = 1/189 (0%)

Query: 96  EPLVKPQSQAQ-VEPVGLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLK 154
           E LVK  +  Q +   GL     AA      ++   L +G  P+  +    TALH A   
Sbjct: 415 ELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARA 474

Query: 155 GHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPL 214
           G  ++V  LL  GA VDAR   ++TP+  A R G   I++ LL   A  +A    G TPL
Sbjct: 475 GQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPL 534

Query: 215 HVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNA 274
           H++ R    D    L+E GA  +   K+G T LH A ++GS    KLLL   A       
Sbjct: 535 HISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGK 594

Query: 275 ASVTPVQLA 283
             +TP+ +A
Sbjct: 595 NGLTPLHVA 603



 Score = 79.0 bits (193), Expect = 5e-15
 Identities = 66/204 (32%), Positives = 98/204 (48%), Gaps = 5/204 (2%)

Query: 102 QSQAQVEPVGLEMF--LKAAAENQEYLIDKYLTDG-GDPNAHDKLHRTALHWACLKGHSQ 158
           Q +A V+ V L+    L  AA    Y + K L D   +PNA      T LH AC K   +
Sbjct: 353 QHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIK 412

Query: 159 LVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAV 218
           ++  L+  GA++ A      TP+  A   GHL I+  LL  GA  +  +  G T LH+A 
Sbjct: 413 VMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAA 472

Query: 219 RTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVT 278
           R    + +  L+  GA ++A+ +E  T LH A R G  + ++LLL + A          T
Sbjct: 473 RAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYT 532

Query: 279 PVQL-ARDWQRGIREA-LQAHVAH 300
           P+ + AR+ Q  +    L+A  AH
Sbjct: 533 PLHISAREGQVDVASVLLEAGAAH 556



 Score = 76.6 bits (187), Expect = 2e-14
 Identities = 53/166 (31%), Positives = 79/166 (47%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLD 177
           A+      ++   L  GG  +A  +   T LH A   GH Q+V  LL  GA + AR    
Sbjct: 273 ASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNG 332

Query: 178 RTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLN 237
            +P+  A +G H+  +K LL   A V+       T LHVA    H    + L++  A+ N
Sbjct: 333 LSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPN 392

Query: 238 AQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
           A+   G T LH A +    K M+LL+ YGA +     + +TP+ +A
Sbjct: 393 ARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVA 438



 Score = 75.9 bits (185), Expect = 4e-14
 Identities = 49/166 (29%), Positives = 80/166 (48%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLD 177
           A  +N+  +++  +  G    A  +   T +H A   GH  +V  LL  GA+ D  ++  
Sbjct: 405 ACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRG 464

Query: 178 RTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLN 237
            T +  A R G + +++ LL  GA V+AR +   TPLH+A R    + ++ L++  AH +
Sbjct: 465 ETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPD 524

Query: 238 AQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
           A    G T LH + R G      +LL  GA   +      TP+ +A
Sbjct: 525 AATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVA 570



 Score = 75.9 bits (185), Expect = 4e-14
 Identities = 51/167 (30%), Positives = 80/167 (47%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLD 177
           AA +NQ  +    L  G + N   K   T LH A  +GH+ +V  LL  GA +       
Sbjct: 636 AAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSG 695

Query: 178 RTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLN 237
            T +  A +   + +   L   GA  +A  K+G TPL VA    +   +  L++ GA++N
Sbjct: 696 LTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVN 755

Query: 238 AQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLAR 284
           A+ K G T LH+A + G    + +LL +GA+     A   T + +A+
Sbjct: 756 AKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAK 802



 Score = 72.0 bits (175), Expect = 6e-13
 Identities = 54/172 (31%), Positives = 79/172 (45%), Gaps = 1/172 (0%)

Query: 131 LTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHL 190
           L  G  P+A  K   T LH A  K   Q+ + LL  GA  +       TP+  A + GH 
Sbjct: 616 LEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHT 675

Query: 191 VILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEA 250
            ++  LL++GA ++   K G T LH+A +    +  + L + GA  +A  K G T L  A
Sbjct: 676 DMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVA 735

Query: 251 VRHGSYKAMKLLLLYGAELGVRNAASVTPV-QLARDWQRGIREALQAHVAHP 301
             +G+ K +  LL  GA +  +     TP+ Q A+     I   L  H A P
Sbjct: 736 CHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKP 787



 Score = 70.1 bits (170), Expect = 2e-12
 Identities = 50/147 (34%), Positives = 68/147 (46%)

Query: 137 PNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQL 196
           P+A      T LH +  +G   + + LL AGA          TP+  A + G L + K L
Sbjct: 523 PDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLL 582

Query: 197 LNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSY 256
           L + A  ++  K G TPLHVA    +      L+E GA  +A  K G T LH A +    
Sbjct: 583 LQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQM 642

Query: 257 KAMKLLLLYGAELGVRNAASVTPVQLA 283
           +    LL YGAE  +     VTP+ LA
Sbjct: 643 QIASTLLNYGAETNIVTKQGVTPLHLA 669



 Score = 69.7 bits (169), Expect = 3e-12
 Identities = 55/173 (31%), Positives = 76/173 (43%)

Query: 111 GLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATV 170
           GL     AA    + +++  L  G    A  K   + LH A    H + V  LL   A V
Sbjct: 299 GLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPV 358

Query: 171 DARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLI 230
           D   L   T +  A   GH  + K LL++ A  NAR   G TPLH+A +      +E L+
Sbjct: 359 DDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLV 418

Query: 231 ECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
           + GA + A  + G T +H A   G    + LLL  GA   V N    T + +A
Sbjct: 419 KYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMA 471



 Score = 69.3 bits (168), Expect = 4e-12
 Identities = 49/153 (32%), Positives = 75/153 (49%), Gaps = 4/153 (2%)

Query: 111 GLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATV 170
           GL     AA E    L+ + L  G   ++  K   TALH A L G +++V  L+  GA +
Sbjct: 64  GLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI 123

Query: 171 DARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLI 230
           +A+     TP++ A +  H+ ++K LL  GA  +   + G TPL VA++  H   +  L+
Sbjct: 124 NAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL 183

Query: 231 ECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLL 263
           E     + + K    ALH A R    K+  LLL
Sbjct: 184 E----NDTKGKVRLPALHIAARKDDTKSAALLL 212



 Score = 68.9 bits (167), Expect = 5e-12
 Identities = 44/122 (36%), Positives = 67/122 (54%)

Query: 146 TALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNA 205
           T LH A   G+  +   LL  GA VD       TP+  A + G+  ++K LL++G +++A
Sbjct: 235 TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 294

Query: 206 RDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLY 265
           + + G TPLH A R+ H   +E L+E GA L A+ K G + LH A +    + +K LL +
Sbjct: 295 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH 354

Query: 266 GA 267
            A
Sbjct: 355 KA 356



 Score = 66.2 bits (160), Expect = 3e-11
 Identities = 43/138 (31%), Positives = 65/138 (47%)

Query: 146 TALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNA 205
           T LH A    + ++   LL  GA+  A      TP+  A +   + I   LLN GA  N 
Sbjct: 598 TPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI 657

Query: 206 RDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLY 265
             K G TPLH+A +  H D +  L++ GA+++   K G T+LH A +        +L  +
Sbjct: 658 VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKH 717

Query: 266 GAELGVRNAASVTPVQLA 283
           GA+         TP+ +A
Sbjct: 718 GADQDAHTKLGYTPLIVA 735



 Score = 65.9 bits (159), Expect = 4e-11
 Identities = 47/150 (31%), Positives = 81/150 (54%), Gaps = 8/150 (5%)

Query: 142 KLHRTALHWACLKGHSQLVNKLLVA--GATVDARDLLDRT------PVFWACRGGHLVIL 193
           K+   ALH A  K  ++    LL     A V ++ +++RT      P+  A   G++ + 
Sbjct: 190 KVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVA 249

Query: 194 KQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRH 253
             LLN+GA V+   + G TPLHVA +  + + ++ L++ G  ++A+ ++G T LH A R 
Sbjct: 250 TLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARS 309

Query: 254 GSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
           G  + ++LLL  GA L  R    ++P+ +A
Sbjct: 310 GHDQVVELLLERGAPLLARTKNGLSPLHMA 339



 Score = 64.7 bits (156), Expect = 1e-10
 Identities = 51/166 (30%), Positives = 75/166 (45%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLD 177
           AA   Q  ++   L +G   +A  +  +T LH A   G +++V  LL   A  DA     
Sbjct: 471 AARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNG 530

Query: 178 RTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLN 237
            TP+  + R G + +   LL  GA  +   K G TPLHVA +    D  + L++  A  +
Sbjct: 531 YTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAAD 590

Query: 238 AQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
           +  K G T LH A  + + K   LLL  GA          TP+ +A
Sbjct: 591 SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIA 636



 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 42/109 (38%), Positives = 57/109 (52%)

Query: 111 GLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATV 170
           GL     AA E++  + D     G D +AH KL  T L  AC  G+ ++VN LL  GA V
Sbjct: 695 GLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANV 754

Query: 171 DARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVR 219
           +A+     TP+  A + GH  I+  LL  GA+ NA    G+T L +A R
Sbjct: 755 NAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKR 803



 Score = 62.0 bits (149), Expect = 6e-10
 Identities = 49/166 (29%), Positives = 70/166 (42%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLD 177
           +A E Q  +    L  G   +   K   T LH A   G   +   LL   A  D+     
Sbjct: 537 SAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNG 596

Query: 178 RTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLN 237
            TP+  A    +  +   LL +GA  +A  K G TPLH+A +         L+  GA  N
Sbjct: 597 LTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETN 656

Query: 238 AQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
              K+G T LH A + G    + LLL  GA + +   + +T + LA
Sbjct: 657 IVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLA 702



 Score = 59.7 bits (143), Expect = 3e-09
 Identities = 39/144 (27%), Positives = 73/144 (50%), Gaps = 2/144 (1%)

Query: 151 ACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIG 210
           A   G+   V + L  G  ++  +      +  A + GH+ ++++LL +G+ V++  K G
Sbjct: 38  AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97

Query: 211 STPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELG 270
           +T LH+A      + ++ L++ GA++NAQ + G T L+ A +      +K LL  GA   
Sbjct: 98  NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 157

Query: 271 VRNAASVTPVQLARDWQRGIREAL 294
                  TP+ +A   Q+G  +A+
Sbjct: 158 TATEDGFTPLAVA--LQQGHNQAV 179


>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
          Length = 3957

 Score = 84.3 bits (207), Expect = 1e-16
 Identities = 50/149 (33%), Positives = 84/149 (56%)

Query: 115 FLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARD 174
           FL+AA       + +YL  G D N  ++    ALH A  +GH  LV +LL  G++VD+  
Sbjct: 35  FLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSAT 94

Query: 175 LLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGA 234
               T +  A   G   ++K L+ +GA +NA+ + G TPL++A +  H D +++L+E GA
Sbjct: 95  KKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGA 154

Query: 235 HLNAQDKEGDTALHEAVRHGSYKAMKLLL 263
           + +   ++G T L  A++ G  +A+ +LL
Sbjct: 155 NQSTATEDGFTPLAVALQQGHNQAVAILL 183



 Score = 84.0 bits (206), Expect = 2e-16
 Identities = 50/138 (36%), Positives = 76/138 (55%)

Query: 146 TALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNA 205
           T LH A  +G++ +V  LL  G  +DA+     TP+  A R GH  +++ LL +GA + A
Sbjct: 268 TPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLA 327

Query: 206 RDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLY 265
           R K G +PLH+A +  H +C++HL++  A ++    +  TALH A   G Y+  KLLL  
Sbjct: 328 RTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDK 387

Query: 266 GAELGVRNAASVTPVQLA 283
            A    R     TP+ +A
Sbjct: 388 RANPNARALNGFTPLHIA 405



 Score = 82.4 bits (202), Expect = 5e-16
 Identities = 54/157 (34%), Positives = 83/157 (52%), Gaps = 1/157 (0%)

Query: 146 TALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNA 205
           TALH A   GH ++   LL   A  +AR L   TP+  AC+   + +++ L+  GA + A
Sbjct: 367 TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQA 426

Query: 206 RDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLY 265
             + G TP+HVA    H + +  L++ GA  +  +  G+TALH A R G  + ++ LL  
Sbjct: 427 ITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRN 486

Query: 266 GAELGVRNAASVTPVQLA-RDWQRGIREALQAHVAHP 301
           GA +  R     TP+ +A R  +  I + L  H+AHP
Sbjct: 487 GALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHP 523



 Score = 82.4 bits (202), Expect = 5e-16
 Identities = 64/189 (33%), Positives = 89/189 (47%), Gaps = 1/189 (0%)

Query: 96  EPLVKPQSQAQ-VEPVGLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLK 154
           E LVK  +  Q +   GL     AA      ++   L +G  P+  +    TALH A   
Sbjct: 415 ELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARA 474

Query: 155 GHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPL 214
           G  ++V  LL  GA VDAR   ++TP+  A R G   I++ LL   A  +A    G TPL
Sbjct: 475 GQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPL 534

Query: 215 HVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNA 274
           H++ R    D    L+E GA  +   K+G T LH A ++GS    KLLL   A       
Sbjct: 535 HISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGK 594

Query: 275 ASVTPVQLA 283
             +TP+ +A
Sbjct: 595 NGLTPLHVA 603



 Score = 79.0 bits (193), Expect = 5e-15
 Identities = 66/204 (32%), Positives = 98/204 (48%), Gaps = 5/204 (2%)

Query: 102 QSQAQVEPVGLEMF--LKAAAENQEYLIDKYLTDG-GDPNAHDKLHRTALHWACLKGHSQ 158
           Q +A V+ V L+    L  AA    Y + K L D   +PNA      T LH AC K   +
Sbjct: 353 QHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIK 412

Query: 159 LVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAV 218
           ++  L+  GA++ A      TP+  A   GHL I+  LL  GA  +  +  G T LH+A 
Sbjct: 413 VMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAA 472

Query: 219 RTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVT 278
           R    + +  L+  GA ++A+ +E  T LH A R G  + ++LLL + A          T
Sbjct: 473 RAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYT 532

Query: 279 PVQL-ARDWQRGIREA-LQAHVAH 300
           P+ + AR+ Q  +    L+A  AH
Sbjct: 533 PLHISAREGQVDVASVLLEAGAAH 556



 Score = 76.6 bits (187), Expect = 2e-14
 Identities = 53/166 (31%), Positives = 79/166 (47%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLD 177
           A+      ++   L  GG  +A  +   T LH A   GH Q+V  LL  GA + AR    
Sbjct: 273 ASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNG 332

Query: 178 RTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLN 237
            +P+  A +G H+  +K LL   A V+       T LHVA    H    + L++  A+ N
Sbjct: 333 LSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPN 392

Query: 238 AQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
           A+   G T LH A +    K M+LL+ YGA +     + +TP+ +A
Sbjct: 393 ARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVA 438



 Score = 75.9 bits (185), Expect = 4e-14
 Identities = 49/166 (29%), Positives = 80/166 (48%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLD 177
           A  +N+  +++  +  G    A  +   T +H A   GH  +V  LL  GA+ D  ++  
Sbjct: 405 ACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRG 464

Query: 178 RTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLN 237
            T +  A R G + +++ LL  GA V+AR +   TPLH+A R    + ++ L++  AH +
Sbjct: 465 ETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPD 524

Query: 238 AQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
           A    G T LH + R G      +LL  GA   +      TP+ +A
Sbjct: 525 AATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVA 570



 Score = 75.9 bits (185), Expect = 4e-14
 Identities = 51/167 (30%), Positives = 80/167 (47%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLD 177
           AA +NQ  +    L  G + N   K   T LH A  +GH+ +V  LL  GA +       
Sbjct: 636 AAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSG 695

Query: 178 RTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLN 237
            T +  A +   + +   L   GA  +A  K+G TPL VA    +   +  L++ GA++N
Sbjct: 696 LTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVN 755

Query: 238 AQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLAR 284
           A+ K G T LH+A + G    + +LL +GA+     A   T + +A+
Sbjct: 756 AKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAK 802



 Score = 72.0 bits (175), Expect = 6e-13
 Identities = 54/172 (31%), Positives = 79/172 (45%), Gaps = 1/172 (0%)

Query: 131 LTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHL 190
           L  G  P+A  K   T LH A  K   Q+ + LL  GA  +       TP+  A + GH 
Sbjct: 616 LEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHT 675

Query: 191 VILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEA 250
            ++  LL++GA ++   K G T LH+A +    +  + L + GA  +A  K G T L  A
Sbjct: 676 DMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVA 735

Query: 251 VRHGSYKAMKLLLLYGAELGVRNAASVTPV-QLARDWQRGIREALQAHVAHP 301
             +G+ K +  LL  GA +  +     TP+ Q A+     I   L  H A P
Sbjct: 736 CHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKP 787



 Score = 70.1 bits (170), Expect = 2e-12
 Identities = 50/147 (34%), Positives = 68/147 (46%)

Query: 137 PNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQL 196
           P+A      T LH +  +G   + + LL AGA          TP+  A + G L + K L
Sbjct: 523 PDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLL 582

Query: 197 LNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSY 256
           L + A  ++  K G TPLHVA    +      L+E GA  +A  K G T LH A +    
Sbjct: 583 LQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQM 642

Query: 257 KAMKLLLLYGAELGVRNAASVTPVQLA 283
           +    LL YGAE  +     VTP+ LA
Sbjct: 643 QIASTLLNYGAETNIVTKQGVTPLHLA 669



 Score = 69.7 bits (169), Expect = 3e-12
 Identities = 55/173 (31%), Positives = 76/173 (43%)

Query: 111 GLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATV 170
           GL     AA    + +++  L  G    A  K   + LH A    H + V  LL   A V
Sbjct: 299 GLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPV 358

Query: 171 DARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLI 230
           D   L   T +  A   GH  + K LL++ A  NAR   G TPLH+A +      +E L+
Sbjct: 359 DDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLV 418

Query: 231 ECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
           + GA + A  + G T +H A   G    + LLL  GA   V N    T + +A
Sbjct: 419 KYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMA 471



 Score = 69.3 bits (168), Expect = 4e-12
 Identities = 49/153 (32%), Positives = 75/153 (49%), Gaps = 4/153 (2%)

Query: 111 GLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATV 170
           GL     AA E    L+ + L  G   ++  K   TALH A L G +++V  L+  GA +
Sbjct: 64  GLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI 123

Query: 171 DARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLI 230
           +A+     TP++ A +  H+ ++K LL  GA  +   + G TPL VA++  H   +  L+
Sbjct: 124 NAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL 183

Query: 231 ECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLL 263
           E     + + K    ALH A R    K+  LLL
Sbjct: 184 E----NDTKGKVRLPALHIAARKDDTKSAALLL 212



 Score = 68.9 bits (167), Expect = 5e-12
 Identities = 44/122 (36%), Positives = 67/122 (54%)

Query: 146 TALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNA 205
           T LH A   G+  +   LL  GA VD       TP+  A + G+  ++K LL++G +++A
Sbjct: 235 TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 294

Query: 206 RDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLY 265
           + + G TPLH A R+ H   +E L+E GA L A+ K G + LH A +    + +K LL +
Sbjct: 295 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH 354

Query: 266 GA 267
            A
Sbjct: 355 KA 356



 Score = 66.2 bits (160), Expect = 3e-11
 Identities = 43/138 (31%), Positives = 65/138 (47%)

Query: 146 TALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNA 205
           T LH A    + ++   LL  GA+  A      TP+  A +   + I   LLN GA  N 
Sbjct: 598 TPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI 657

Query: 206 RDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLY 265
             K G TPLH+A +  H D +  L++ GA+++   K G T+LH A +        +L  +
Sbjct: 658 VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKH 717

Query: 266 GAELGVRNAASVTPVQLA 283
           GA+         TP+ +A
Sbjct: 718 GADQDAHTKLGYTPLIVA 735



 Score = 65.9 bits (159), Expect = 4e-11
 Identities = 47/150 (31%), Positives = 81/150 (54%), Gaps = 8/150 (5%)

Query: 142 KLHRTALHWACLKGHSQLVNKLLVA--GATVDARDLLDRT------PVFWACRGGHLVIL 193
           K+   ALH A  K  ++    LL     A V ++ +++RT      P+  A   G++ + 
Sbjct: 190 KVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVA 249

Query: 194 KQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRH 253
             LLN+GA V+   + G TPLHVA +  + + ++ L++ G  ++A+ ++G T LH A R 
Sbjct: 250 TLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARS 309

Query: 254 GSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
           G  + ++LLL  GA L  R    ++P+ +A
Sbjct: 310 GHDQVVELLLERGAPLLARTKNGLSPLHMA 339



 Score = 64.7 bits (156), Expect = 1e-10
 Identities = 51/166 (30%), Positives = 75/166 (45%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLD 177
           AA   Q  ++   L +G   +A  +  +T LH A   G +++V  LL   A  DA     
Sbjct: 471 AARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNG 530

Query: 178 RTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLN 237
            TP+  + R G + +   LL  GA  +   K G TPLHVA +    D  + L++  A  +
Sbjct: 531 YTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAAD 590

Query: 238 AQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
           +  K G T LH A  + + K   LLL  GA          TP+ +A
Sbjct: 591 SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIA 636



 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 42/109 (38%), Positives = 57/109 (52%)

Query: 111 GLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATV 170
           GL     AA E++  + D     G D +AH KL  T L  AC  G+ ++VN LL  GA V
Sbjct: 695 GLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANV 754

Query: 171 DARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVR 219
           +A+     TP+  A + GH  I+  LL  GA+ NA    G+T L +A R
Sbjct: 755 NAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKR 803



 Score = 62.0 bits (149), Expect = 6e-10
 Identities = 49/166 (29%), Positives = 70/166 (42%)

Query: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLD 177
           +A E Q  +    L  G   +   K   T LH A   G   +   LL   A  D+     
Sbjct: 537 SAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNG 596

Query: 178 RTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLN 237
            TP+  A    +  +   LL +GA  +A  K G TPLH+A +         L+  GA  N
Sbjct: 597 LTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETN 656

Query: 238 AQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
              K+G T LH A + G    + LLL  GA + +   + +T + LA
Sbjct: 657 IVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLA 702



 Score = 59.7 bits (143), Expect = 3e-09
 Identities = 39/144 (27%), Positives = 73/144 (50%), Gaps = 2/144 (1%)

Query: 151 ACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIG 210
           A   G+   V + L  G  ++  +      +  A + GH+ ++++LL +G+ V++  K G
Sbjct: 38  AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97

Query: 211 STPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELG 270
           +T LH+A      + ++ L++ GA++NAQ + G T L+ A +      +K LL  GA   
Sbjct: 98  NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 157

Query: 271 VRNAASVTPVQLARDWQRGIREAL 294
                  TP+ +A   Q+G  +A+
Sbjct: 158 TATEDGFTPLAVA--LQQGHNQAV 179


>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
           [Homo sapiens]
          Length = 2542

 Score = 83.2 bits (204), Expect = 3e-16
 Identities = 66/202 (32%), Positives = 97/202 (48%), Gaps = 6/202 (2%)

Query: 106 QVEPVGLEMFLKAAAENQEYLIDKYLTDGGDPNAH-DKLHRTALHWACLKGHSQLVNKLL 164
           +V   G    ++AA E  E ++   L  G + NA  ++   TAL  AC  G S++ + L+
Sbjct: 466 EVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLI 525

Query: 165 VAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPD 224
            AGA ++   L   TP+  A + GHL ++K LL  GA V+A    G T L  A    H D
Sbjct: 526 KAGADIE---LGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTD 582

Query: 225 CLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAAS-VTPVQLA 283
             + L++ GA L  + + G T L +A R G    ++ L+  GA +    A +  T V LA
Sbjct: 583 VADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLA 642

Query: 284 -RDWQRGIREALQAHVAHPRTR 304
                  + E L AH A P  R
Sbjct: 643 CAGGHLAVVELLLAHGADPTHR 664



 Score = 82.4 bits (202), Expect = 5e-16
 Identities = 58/177 (32%), Positives = 92/177 (51%), Gaps = 4/177 (2%)

Query: 111  GLEMFLKAAAENQEYLIDKYLTDGGDPNAH-DKLHRTALHWACLKGHSQLVNKLLVAGAT 169
            G    + AA      +++  L  GGD  A  ++   T L  AC  G  ++V+ LL  GA 
Sbjct: 1088 GFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGAN 1147

Query: 170  VDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNAR--DKIGSTPLHVAVRTRHPDCLE 227
             + R++ D TP+  A  GG++ I+K LLN GA +N+R   K+G +PL +A    H   ++
Sbjct: 1148 KEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVK 1207

Query: 228  HLIECGAHLNAQ-DKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
             L++ G+ +NAQ +   +TAL  A   G  + + LLL   A +  R    +TP+  A
Sbjct: 1208 LLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEA 1264



 Score = 79.3 bits (194), Expect = 4e-15
 Identities = 57/177 (32%), Positives = 91/177 (51%), Gaps = 3/177 (1%)

Query: 110  VGLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHR-TALHWACLKGHSQLVNKLLVAGA 168
            +G+   + AA       +   L  G D NA  + +R TAL  AC +G +++V+ LL   A
Sbjct: 1189 LGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKA 1248

Query: 169  TVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGS--TPLHVAVRTRHPDCL 226
             V+ R     TP+  A  GG+  + + LL++GA VNA     S  T L +A    H    
Sbjct: 1249 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFC 1308

Query: 227  EHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
            E LI  GAH++ ++K+G+T L  A   G +  ++LL+  GA++   +   +TP+  A
Sbjct: 1309 ELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSA 1365



 Score = 76.6 bits (187), Expect = 2e-14
 Identities = 53/158 (33%), Positives = 78/158 (49%), Gaps = 1/158 (0%)

Query: 116 LKAAAENQEYLIDKYLTDGGDPNAH-DKLHRTALHWACLKGHSQLVNKLLVAGATVDARD 174
           ++AA+     +    L  G   N H ++   +AL  AC KGH  +V  LL AGA  + + 
Sbjct: 343 MEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKT 402

Query: 175 LLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGA 234
               T +  AC  GH+ + + LL+ GA+VN       +PL +A    H +    LIE GA
Sbjct: 403 DEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGA 462

Query: 235 HLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVR 272
           +L   + EG T L EA R G  + + LLL  GA +  +
Sbjct: 463 NLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQ 500



 Score = 69.3 bits (168), Expect = 4e-12
 Identities = 47/152 (30%), Positives = 80/152 (52%), Gaps = 4/152 (2%)

Query: 136  DPNAH-DKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILK 194
            D +AH +  H TAL  AC  GH +LV+ L+   A ++ RD    TP+  A   GH+ +++
Sbjct: 1046 DIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVE 1105

Query: 195  QLLNQGARVNAR-DKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRH 253
             LL++G  + A+ ++   TPL +A      + ++ L+  GA+   ++    T L  A   
Sbjct: 1106 ILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASG 1165

Query: 254  GSYKAMKLLLLYGAELGVRNAA--SVTPVQLA 283
            G    +K+LL  GAE+  R  +   ++P+ LA
Sbjct: 1166 GYVNIIKILLNAGAEINSRTGSKLGISPLMLA 1197



 Score = 68.9 bits (167), Expect = 5e-12
 Identities = 50/176 (28%), Positives = 83/176 (47%), Gaps = 1/176 (0%)

Query: 99  VKPQSQAQVEPVGLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQ 158
           +K ++      V      +A ++     + K L +G   N H +   + L  AC  G+ +
Sbjct: 193 MKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYE 252

Query: 159 LVNKLLVAGATVDAR-DLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVA 217
           L   LL   A V+ R +  D TP+  A  GG+L I+K LL   A VN++   G+T L  A
Sbjct: 253 LAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYA 312

Query: 218 VRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRN 273
                 D ++ L+  GA++   ++ G T L EA   G  +  ++LL +GA +   +
Sbjct: 313 CAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHS 368



 Score = 66.2 bits (160), Expect = 3e-11
 Identities = 47/144 (32%), Positives = 76/144 (52%), Gaps = 4/144 (2%)

Query: 129 KYLTDGGDPNAH--DKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACR 186
           ++L + G    H  D++H TAL  AC+ GH ++   LL +GA V+       +P+  A  
Sbjct: 389 RFLLEAGADQEHKTDEMH-TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC 447

Query: 187 GGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKE-GDT 245
           GGH+ +   L+ +GA +   +  G TPL  A R  H + +  L+  GA++NAQ +E  +T
Sbjct: 448 GGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQET 507

Query: 246 ALHEAVRHGSYKAMKLLLLYGAEL 269
           AL  A   G  +    L+  GA++
Sbjct: 508 ALTLACCGGFSEVADFLIKAGADI 531



 Score = 60.1 bits (144), Expect = 2e-09
 Identities = 40/124 (32%), Positives = 63/124 (50%), Gaps = 1/124 (0%)

Query: 146 TALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNA 205
           T L  A   G+  +V  LL+  A V+++     T + +AC GG + I+K LLN+GA +  
Sbjct: 274 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 333

Query: 206 RDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKE-GDTALHEAVRHGSYKAMKLLLL 264
            ++ G TPL  A    H +    L++ GA +N    E  ++AL  A   G    ++ LL 
Sbjct: 334 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 393

Query: 265 YGAE 268
            GA+
Sbjct: 394 AGAD 397



 Score = 58.2 bits (139), Expect = 9e-09
 Identities = 44/127 (34%), Positives = 63/127 (49%), Gaps = 10/127 (7%)

Query: 111  GLEMFLKAA----AENQEYLIDKYLTDGGDPNAHD--KLHRTALHWACLKGHSQLVNKLL 164
            GL   ++AA    AE    L+DK    G D NA        TAL  A  KGH +    L+
Sbjct: 1257 GLTPLMEAASGGYAEVGRVLLDK----GADVNAPPVPSSRDTALTIAADKGHYKFCELLI 1312

Query: 165  VAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPD 224
              GA +D R+    TP++ A  GGH  +++ L+  GA V+A D    TPL  A R  H  
Sbjct: 1313 HRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVK 1372

Query: 225  CLEHLIE 231
             +++L++
Sbjct: 1373 VVQYLVK 1379



 Score = 51.2 bits (121), Expect = 1e-06
 Identities = 45/149 (30%), Positives = 68/149 (45%), Gaps = 3/149 (2%)

Query: 138 NAHD--KLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQ 195
           N+H+  ++   +L  AC  G    V KLL  G +V+       + +  AC  G+  + + 
Sbjct: 197 NSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV 256

Query: 196 LLNQGARVNARDKIGS-TPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHG 254
           LL   A V  R   G  TPL  A    + D ++ L+   A +N+Q   G+TAL  A   G
Sbjct: 257 LLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGG 316

Query: 255 SYKAMKLLLLYGAELGVRNAASVTPVQLA 283
               +K+LL  GA +   N    TP+  A
Sbjct: 317 FVDIVKVLLNEGANIEDHNENGHTPLMEA 345



 Score = 51.2 bits (121), Expect = 1e-06
 Identities = 41/150 (27%), Positives = 62/150 (41%), Gaps = 34/150 (22%)

Query: 116 LKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDL 175
           ++A+ E    L+   L  G + +A      TAL +AC  GH+ + + LL AGA ++    
Sbjct: 540 MEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESE 599

Query: 176 LDRTP----------------------------------VFWACRGGHLVILKQLLNQGA 201
             RTP                                  V  AC GGHL +++ LL  GA
Sbjct: 600 GGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGA 659

Query: 202 RVNARDKIGSTPLHVAVRTRHPDCLEHLIE 231
               R K GST L  A +  H + + +L++
Sbjct: 660 DPTHRLKDGSTMLIEAAKGGHTNVVSYLLD 689



 Score = 39.7 bits (91), Expect = 0.003
 Identities = 29/92 (31%), Positives = 43/92 (46%), Gaps = 1/92 (1%)

Query: 109  PVGLEMFLKAAAENQEYLIDKYLTD-GGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAG 167
            P   +  L  AA+   Y   + L   G   +  +K   T L  A   GH  +V  L+ AG
Sbjct: 1289 PSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAG 1348

Query: 168  ATVDARDLLDRTPVFWACRGGHLVILKQLLNQ 199
            A VDA D    TP+  A R GH+ +++ L+ +
Sbjct: 1349 ADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380


>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
          Length = 2617

 Score = 83.2 bits (204), Expect = 3e-16
 Identities = 66/202 (32%), Positives = 97/202 (48%), Gaps = 6/202 (2%)

Query: 106 QVEPVGLEMFLKAAAENQEYLIDKYLTDGGDPNAH-DKLHRTALHWACLKGHSQLVNKLL 164
           +V   G    ++AA E  E ++   L  G + NA  ++   TAL  AC  G S++ + L+
Sbjct: 466 EVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLI 525

Query: 165 VAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPD 224
            AGA ++   L   TP+  A + GHL ++K LL  GA V+A    G T L  A    H D
Sbjct: 526 KAGADIE---LGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTD 582

Query: 225 CLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAAS-VTPVQLA 283
             + L++ GA L  + + G T L +A R G    ++ L+  GA +    A +  T V LA
Sbjct: 583 VADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLA 642

Query: 284 -RDWQRGIREALQAHVAHPRTR 304
                  + E L AH A P  R
Sbjct: 643 CAGGHLAVVELLLAHGADPTHR 664



 Score = 82.4 bits (202), Expect = 5e-16
 Identities = 58/177 (32%), Positives = 92/177 (51%), Gaps = 4/177 (2%)

Query: 111  GLEMFLKAAAENQEYLIDKYLTDGGDPNAH-DKLHRTALHWACLKGHSQLVNKLLVAGAT 169
            G    + AA      +++  L  GGD  A  ++   T L  AC  G  ++V+ LL  GA 
Sbjct: 1088 GFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGAN 1147

Query: 170  VDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNAR--DKIGSTPLHVAVRTRHPDCLE 227
             + R++ D TP+  A  GG++ I+K LLN GA +N+R   K+G +PL +A    H   ++
Sbjct: 1148 KEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVK 1207

Query: 228  HLIECGAHLNAQ-DKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
             L++ G+ +NAQ +   +TAL  A   G  + + LLL   A +  R    +TP+  A
Sbjct: 1208 LLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEA 1264



 Score = 79.3 bits (194), Expect = 4e-15
 Identities = 57/177 (32%), Positives = 91/177 (51%), Gaps = 3/177 (1%)

Query: 110  VGLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHR-TALHWACLKGHSQLVNKLLVAGA 168
            +G+   + AA       +   L  G D NA  + +R TAL  AC +G +++V+ LL   A
Sbjct: 1189 LGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKA 1248

Query: 169  TVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGS--TPLHVAVRTRHPDCL 226
             V+ R     TP+  A  GG+  + + LL++GA VNA     S  T L +A    H    
Sbjct: 1249 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFC 1308

Query: 227  EHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
            E LI  GAH++ ++K+G+T L  A   G +  ++LL+  GA++   +   +TP+  A
Sbjct: 1309 ELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSA 1365



 Score = 76.6 bits (187), Expect = 2e-14
 Identities = 53/158 (33%), Positives = 78/158 (49%), Gaps = 1/158 (0%)

Query: 116 LKAAAENQEYLIDKYLTDGGDPNAH-DKLHRTALHWACLKGHSQLVNKLLVAGATVDARD 174
           ++AA+     +    L  G   N H ++   +AL  AC KGH  +V  LL AGA  + + 
Sbjct: 343 MEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKT 402

Query: 175 LLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGA 234
               T +  AC  GH+ + + LL+ GA+VN       +PL +A    H +    LIE GA
Sbjct: 403 DEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGA 462

Query: 235 HLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVR 272
           +L   + EG T L EA R G  + + LLL  GA +  +
Sbjct: 463 NLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQ 500



 Score = 69.3 bits (168), Expect = 4e-12
 Identities = 47/152 (30%), Positives = 80/152 (52%), Gaps = 4/152 (2%)

Query: 136  DPNAH-DKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILK 194
            D +AH +  H TAL  AC  GH +LV+ L+   A ++ RD    TP+  A   GH+ +++
Sbjct: 1046 DIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVE 1105

Query: 195  QLLNQGARVNAR-DKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRH 253
             LL++G  + A+ ++   TPL +A      + ++ L+  GA+   ++    T L  A   
Sbjct: 1106 ILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASG 1165

Query: 254  GSYKAMKLLLLYGAELGVRNAA--SVTPVQLA 283
            G    +K+LL  GAE+  R  +   ++P+ LA
Sbjct: 1166 GYVNIIKILLNAGAEINSRTGSKLGISPLMLA 1197



 Score = 68.9 bits (167), Expect = 5e-12
 Identities = 50/176 (28%), Positives = 83/176 (47%), Gaps = 1/176 (0%)

Query: 99  VKPQSQAQVEPVGLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQ 158
           +K ++      V      +A ++     + K L +G   N H +   + L  AC  G+ +
Sbjct: 193 MKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYE 252

Query: 159 LVNKLLVAGATVDAR-DLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVA 217
           L   LL   A V+ R +  D TP+  A  GG+L I+K LL   A VN++   G+T L  A
Sbjct: 253 LAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYA 312

Query: 218 VRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRN 273
                 D ++ L+  GA++   ++ G T L EA   G  +  ++LL +GA +   +
Sbjct: 313 CAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHS 368



 Score = 66.2 bits (160), Expect = 3e-11
 Identities = 47/144 (32%), Positives = 76/144 (52%), Gaps = 4/144 (2%)

Query: 129 KYLTDGGDPNAH--DKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACR 186
           ++L + G    H  D++H TAL  AC+ GH ++   LL +GA V+       +P+  A  
Sbjct: 389 RFLLEAGADQEHKTDEMH-TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC 447

Query: 187 GGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKE-GDT 245
           GGH+ +   L+ +GA +   +  G TPL  A R  H + +  L+  GA++NAQ +E  +T
Sbjct: 448 GGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQET 507

Query: 246 ALHEAVRHGSYKAMKLLLLYGAEL 269
           AL  A   G  +    L+  GA++
Sbjct: 508 ALTLACCGGFSEVADFLIKAGADI 531



 Score = 60.1 bits (144), Expect = 2e-09
 Identities = 40/124 (32%), Positives = 63/124 (50%), Gaps = 1/124 (0%)

Query: 146 TALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNA 205
           T L  A   G+  +V  LL+  A V+++     T + +AC GG + I+K LLN+GA +  
Sbjct: 274 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 333

Query: 206 RDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKE-GDTALHEAVRHGSYKAMKLLLL 264
            ++ G TPL  A    H +    L++ GA +N    E  ++AL  A   G    ++ LL 
Sbjct: 334 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 393

Query: 265 YGAE 268
            GA+
Sbjct: 394 AGAD 397



 Score = 58.2 bits (139), Expect = 9e-09
 Identities = 44/127 (34%), Positives = 63/127 (49%), Gaps = 10/127 (7%)

Query: 111  GLEMFLKAA----AENQEYLIDKYLTDGGDPNAHD--KLHRTALHWACLKGHSQLVNKLL 164
            GL   ++AA    AE    L+DK    G D NA        TAL  A  KGH +    L+
Sbjct: 1257 GLTPLMEAASGGYAEVGRVLLDK----GADVNAPPVPSSRDTALTIAADKGHYKFCELLI 1312

Query: 165  VAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPD 224
              GA +D R+    TP++ A  GGH  +++ L+  GA V+A D    TPL  A R  H  
Sbjct: 1313 HRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVK 1372

Query: 225  CLEHLIE 231
             +++L++
Sbjct: 1373 VVQYLVK 1379



 Score = 51.2 bits (121), Expect = 1e-06
 Identities = 45/149 (30%), Positives = 68/149 (45%), Gaps = 3/149 (2%)

Query: 138 NAHD--KLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQ 195
           N+H+  ++   +L  AC  G    V KLL  G +V+       + +  AC  G+  + + 
Sbjct: 197 NSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV 256

Query: 196 LLNQGARVNARDKIGS-TPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHG 254
           LL   A V  R   G  TPL  A    + D ++ L+   A +N+Q   G+TAL  A   G
Sbjct: 257 LLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGG 316

Query: 255 SYKAMKLLLLYGAELGVRNAASVTPVQLA 283
               +K+LL  GA +   N    TP+  A
Sbjct: 317 FVDIVKVLLNEGANIEDHNENGHTPLMEA 345



 Score = 51.2 bits (121), Expect = 1e-06
 Identities = 41/150 (27%), Positives = 62/150 (41%), Gaps = 34/150 (22%)

Query: 116 LKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDL 175
           ++A+ E    L+   L  G + +A      TAL +AC  GH+ + + LL AGA ++    
Sbjct: 540 MEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESE 599

Query: 176 LDRTP----------------------------------VFWACRGGHLVILKQLLNQGA 201
             RTP                                  V  AC GGHL +++ LL  GA
Sbjct: 600 GGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGA 659

Query: 202 RVNARDKIGSTPLHVAVRTRHPDCLEHLIE 231
               R K GST L  A +  H + + +L++
Sbjct: 660 DPTHRLKDGSTMLIEAAKGGHTNVVSYLLD 689



 Score = 39.7 bits (91), Expect = 0.003
 Identities = 29/92 (31%), Positives = 43/92 (46%), Gaps = 1/92 (1%)

Query: 109  PVGLEMFLKAAAENQEYLIDKYLTD-GGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAG 167
            P   +  L  AA+   Y   + L   G   +  +K   T L  A   GH  +V  L+ AG
Sbjct: 1289 PSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAG 1348

Query: 168  ATVDARDLLDRTPVFWACRGGHLVILKQLLNQ 199
            A VDA D    TP+  A R GH+ +++ L+ +
Sbjct: 1349 ADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380


>gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled-coil
            containing 2 [Homo sapiens]
          Length = 1990

 Score = 82.8 bits (203), Expect = 3e-16
 Identities = 52/153 (33%), Positives = 76/153 (49%)

Query: 126  LIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWAC 185
            ++D  LT G D N  DK  RT L  A  +GH   V+ LL  GA++   D    T + WAC
Sbjct: 1082 IVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWAC 1141

Query: 186  RGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDT 245
              GHL +++ L++ GA  +  DK G TPL +A      + ++ L++ GA +   D  G  
Sbjct: 1142 LKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMR 1201

Query: 246  ALHEAVRHGSYKAMKLLLLYGAELGVRNAASVT 278
             L  AV   +   +  LL  GA++G    A  T
Sbjct: 1202 PLDRAVGCRNTSVVVTLLKKGAKIGPATWAMAT 1234



 Score = 69.7 bits (169), Expect = 3e-12
 Identities = 57/164 (34%), Positives = 76/164 (46%), Gaps = 3/164 (1%)

Query: 138  NAHDKLH-RTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQL 196
            N+ D L   TAL  A  +G  ++   LL  GA V   +     P+F   R GH  I+  L
Sbjct: 1027 NSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLL 1086

Query: 197  LNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSY 256
            L  GA VN  DK G TPL +A    H   ++ L+  GA +   DKEG TAL  A   G  
Sbjct: 1087 LTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHL 1146

Query: 257  KAMKLLLLYGAELGVRNAASVTPVQLARDWQRGIREALQAHVAH 300
              ++ L+  GA     +    TP+ LA  +  G  E +Q  V H
Sbjct: 1147 SVVRSLVDNGAATDHADKNGRTPLDLAAFY--GDAEVVQFLVDH 1188



 Score = 68.6 bits (166), Expect = 7e-12
 Identities = 57/193 (29%), Positives = 88/193 (45%), Gaps = 1/193 (0%)

Query: 92   PRKPEPLVKPQSQAQVEPVGLEMFLKAAAENQEYLIDKYLTDGGDPNAH-DKLHRTALHW 150
            P K E  V+       + +  E  L AAA   +  + + L + G   A  ++     L  
Sbjct: 1014 PEKDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFS 1073

Query: 151  ACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIG 210
               +GH Q+V+ LL  GA V+  D   RTP+  A   GHL  +  LL QGA +   DK G
Sbjct: 1074 TVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEG 1133

Query: 211  STPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELG 270
             T L  A    H   +  L++ GA  +  DK G T L  A  +G  + ++ L+ +GA + 
Sbjct: 1134 LTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIE 1193

Query: 271  VRNAASVTPVQLA 283
              + + + P+  A
Sbjct: 1194 HVDYSGMRPLDRA 1206



 Score = 65.1 bits (157), Expect = 7e-11
 Identities = 43/126 (34%), Positives = 60/126 (47%)

Query: 111  GLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATV 170
            G    + AA+E     +D  L  G      DK   TAL WACLKGH  +V  L+  GA  
Sbjct: 1100 GRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAAT 1159

Query: 171  DARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLI 230
            D  D   RTP+  A   G   +++ L++ GA +   D  G  PL  AV  R+   +  L+
Sbjct: 1160 DHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLL 1219

Query: 231  ECGAHL 236
            + GA +
Sbjct: 1220 KKGAKI 1225



 Score = 43.9 bits (102), Expect = 2e-04
 Identities = 27/78 (34%), Positives = 42/78 (53%)

Query: 155 GHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPL 214
           G++++V  LL  GA VDA      TP+ +A   G+L I+  L  + A+V+  DK G   L
Sbjct: 896 GYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCAL 955

Query: 215 HVAVRTRHPDCLEHLIEC 232
             A    H + ++ LI+C
Sbjct: 956 VHAALRGHLEVVKFLIQC 973



 Score = 39.3 bits (90), Expect = 0.004
 Identities = 31/105 (29%), Positives = 51/105 (48%), Gaps = 6/105 (5%)

Query: 163 LLVAGATVDAR-DLLDRTPVFWACRGGHL---VILKQLLNQGARVNARDKIGSTPLHVAV 218
           L++ GA ++ R ++L+  P+   C   HL    ++  LL  GA V+A  + G TPL  A 
Sbjct: 869 LILGGANINYRTEVLNNAPIL--CVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAA 926

Query: 219 RTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLL 263
              +   +  L +  A ++  DK G  AL  A   G  + +K L+
Sbjct: 927 AAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLI 971


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.136    0.414 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,518,677
Number of Sequences: 37866
Number of extensions: 573991
Number of successful extensions: 5787
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 359
Number of HSP's successfully gapped in prelim test: 53
Number of HSP's that attempted gapping in prelim test: 2496
Number of HSP's gapped (non-prelim): 1994
length of query: 305
length of database: 18,247,518
effective HSP length: 102
effective length of query: 203
effective length of database: 14,385,186
effective search space: 2920192758
effective search space used: 2920192758
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.