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Search of human proteins with 41281398
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
(582 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens] 1137 0.0
gi|238908508 leucine-rich repeat and death domain-containing pro... 219 7e-57
gi|95113664 leucine rich repeat containing 1 [Homo sapiens] 197 2e-50
gi|16904383 leucine rich repeat containing 7 [Homo sapiens] 194 1e-49
gi|122937315 leucine-rich repeats and IQ motif containing 4 [Hom... 193 3e-49
gi|45827729 scribble isoform b [Homo sapiens] 193 4e-49
gi|45827731 scribble isoform a [Homo sapiens] 193 4e-49
gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens] 184 2e-46
gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens] 184 2e-46
gi|21361633 leucine rich repeat containing 40 [Homo sapiens] 180 3e-45
gi|4503743 flightless I homolog [Homo sapiens] 154 2e-37
gi|65301141 PH domain and leucine rich repeat protein phosphatas... 153 5e-37
gi|37221175 PH domain and leucine rich repeat protein phosphatas... 145 1e-34
gi|110825984 malignant fibrous histiocytoma amplified sequence 1... 143 4e-34
gi|62241040 leucine rich repeat containing 8 family, member A [H... 130 4e-30
gi|187829877 leucine rich repeat containing 8 family, member A [... 130 4e-30
gi|187829871 leucine rich repeat containing 8 family, member A [... 130 4e-30
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 127 4e-29
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 127 4e-29
gi|157694513 leucine-rich repeat-containing G protein-coupled re... 125 8e-29
gi|225579152 insulin-like growth factor binding protein, acid la... 125 1e-28
gi|4826772 insulin-like growth factor binding protein, acid labi... 125 1e-28
gi|19923729 leucine rich repeat containing 8 family, member C [H... 120 4e-27
gi|40217803 leucine rich repeat containing 8 family, member E [H... 120 4e-27
gi|197333706 leucine rich repeat containing 8 family, member D [... 119 6e-27
gi|34222199 leucine rich repeat containing 8 family, member D [H... 119 6e-27
gi|4504379 leucine-rich repeat-containing G protein-coupled rece... 118 2e-26
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] 118 2e-26
gi|21389431 leucine rich repeat containing 39 [Homo sapiens] 116 5e-26
gi|62912470 leucine-rich repeat-containing G protein-coupled rec... 115 1e-25
>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
Length = 582
Score = 1137 bits (2940), Expect = 0.0
Identities = 582/582 (100%), Positives = 582/582 (100%)
Query: 1 MSSSLGKEKDSKEKDPKVPSAKEREKEAKASGGFGKESKEKEPKTKGKDAKDGKKDSSAA 60
MSSSLGKEKDSKEKDPKVPSAKEREKEAKASGGFGKESKEKEPKTKGKDAKDGKKDSSAA
Sbjct: 1 MSSSLGKEKDSKEKDPKVPSAKEREKEAKASGGFGKESKEKEPKTKGKDAKDGKKDSSAA 60
Query: 61 QPGVAFSVDNTIKRPNPAPGTRKKSSNAEVIKELNKCREENSMRLDLSKRSIHILPSSIK 120
QPGVAFSVDNTIKRPNPAPGTRKKSSNAEVIKELNKCREENSMRLDLSKRSIHILPSSIK
Sbjct: 61 QPGVAFSVDNTIKRPNPAPGTRKKSSNAEVIKELNKCREENSMRLDLSKRSIHILPSSIK 120
Query: 121 ELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNK 180
ELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNK
Sbjct: 121 ELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNK 180
Query: 181 LREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNL 240
LREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNL
Sbjct: 181 LREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNL 240
Query: 241 ITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIP 300
ITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIP
Sbjct: 241 ITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIP 300
Query: 301 RSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSL 360
RSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSL
Sbjct: 301 RSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSL 360
Query: 361 NMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPED 420
NMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPED
Sbjct: 361 NMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPED 420
Query: 421 VSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTN 480
VSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTN
Sbjct: 421 VSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTN 480
Query: 481 NQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSLPFELALC 540
NQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSLPFELALC
Sbjct: 481 NQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSLPFELALC 540
Query: 541 SKLSIMSIENCPLSHLPPQIVAGGPSFIIQFLKMQGPYRAMV 582
SKLSIMSIENCPLSHLPPQIVAGGPSFIIQFLKMQGPYRAMV
Sbjct: 541 SKLSIMSIENCPLSHLPPQIVAGGPSFIIQFLKMQGPYRAMV 582
>gi|238908508 leucine-rich repeat and death domain-containing
protein [Homo sapiens]
Length = 860
Score = 219 bits (557), Expect = 7e-57
Identities = 143/483 (29%), Positives = 254/483 (52%), Gaps = 28/483 (5%)
Query: 105 LDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDS 164
L++S I +P I +L + +L+ Y+N +++ P+++ CL NL L+L +N L +PD+
Sbjct: 216 LNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRHIPDT 275
Query: 165 LDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRE 224
L +LK LR+L+L +N+L P + L L +L L N I+++ K+I+ L L L +
Sbjct: 276 LPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDH 335
Query: 225 NKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLS 284
NK+ L EI +L + L +A N+LE + +I N ++ L L N L ++P+ I +
Sbjct: 336 NKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCA 395
Query: 285 SLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESL------------------ 326
L L L N+L+ +P+ + K + L +L++ NN+ + + +
Sbjct: 396 MLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITD 455
Query: 327 ----LSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLS 382
+ + K+ + L+ N +P+ G ++Y L++ N I++IP I S +K L
Sbjct: 456 VPIEIKNCQKIIKIELSYNKIMYFPL-GLCALDSLYYLSVNGNYISEIPVDI-SFSKQLL 513
Query: 383 KLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPH 442
L + +N+L F + ++ L+L NQ+ KIP +S ++SL VLIL N + P
Sbjct: 514 HLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPR 573
Query: 443 GLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLG 502
L L L+ LDL EN+L+ + ++I LK +QKL ++NQ P + L +L L +
Sbjct: 574 ELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNIS 633
Query: 503 E---NLLTHLPEEIGTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLSHLPPQ 559
+ LT LP E+ + L+EL +++N + +P + L + N +S+LPP
Sbjct: 634 QIKGRKLTRLPGELSNMTQLKELDISNNA-IREIPRNIGELRNLVSLHAYNNQISYLPPS 692
Query: 560 IVA 562
+++
Sbjct: 693 LLS 695
Score = 187 bits (475), Expect = 2e-47
Identities = 132/429 (30%), Positives = 214/429 (49%), Gaps = 6/429 (1%)
Query: 105 LDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDS 164
LDL+ I LP I+EL L L + NKL L E+ L+ + L L++N L +
Sbjct: 308 LDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHK 367
Query: 165 LDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRE 224
++N ++LR+L L N L+ IP + L L L N++T + K I L+ L L +
Sbjct: 368 IENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNR 427
Query: 225 NKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLS 284
N + ++ I L N+ +L+ + N + +P EI NC +I ++L +N+++ P + L
Sbjct: 428 NNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALD 487
Query: 285 SLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQ 344
SL L + N +S IP ++ L L L N + E S L+ L L L +N +
Sbjct: 488 SLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCS-LINLKYLDLGKNQIK 546
Query: 345 LYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSM 404
P + S ++ L + N+ P + + L L++ +NQL + D +
Sbjct: 547 KIPASISNMIS-LHVLILCCNKFETFPRELCTLEN-LQVLDLSENQLQKISSDICNLKGI 604
Query: 405 VELNLATNQLTKIPEDVSGLVSLEVLILSN---NLLKKLPHGLGNLRKLRELDLEENKLE 461
+LN ++NQ P ++ L SLE L +S L +LP L N+ +L+ELD+ N +
Sbjct: 605 QKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIR 664
Query: 462 SLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEE 521
+P I L++L L NNQ++ LP + L +L L L N LT LP I + +L+E
Sbjct: 665 EIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKE 724
Query: 522 LYLNDNPNL 530
+ +DNP L
Sbjct: 725 INFDDNPLL 733
Score = 150 bits (379), Expect = 3e-36
Identities = 108/395 (27%), Positives = 186/395 (47%), Gaps = 29/395 (7%)
Query: 105 LDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDS 164
L L+ + ++ I+ +L L L N L+++P ++ C L L+LS+N LT LP
Sbjct: 354 LQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKY 413
Query: 165 LDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRE 224
+ L LR L + N + +I + L+++ +L N IT V +IKN K+ + +
Sbjct: 414 IHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSY 473
Query: 225 NKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELL---------- 274
NKI P + L +L L V N + +P +I Q+ +L+L N+LL
Sbjct: 474 NKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLI 533
Query: 275 -------------DLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNIST 321
+P +I N+ SL L L N+ PR L L+ L+L N +
Sbjct: 534 NLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQK 593
Query: 322 LPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEH---NRINKIPFGIFSRA 378
+ S + +L + L + N F +P+ Q ++ LN+ ++ ++P G S
Sbjct: 594 I-SSDICNLKGIQKLNFSSNQFIHFPIE-LCQLQSLEQLNISQIKGRKLTRLP-GELSNM 650
Query: 379 KVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLK 438
L +L++ +N + +P + G ++V L+ NQ++ +P + L L+ L LS N L
Sbjct: 651 TQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLT 710
Query: 439 KLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDL 473
LP + N+ L+E++ ++N L P EI K L
Sbjct: 711 ALPSAIYNIFSLKEINFDDNPLLRPPVEICKGKQL 745
Score = 117 bits (293), Expect = 3e-26
Identities = 100/387 (25%), Positives = 176/387 (45%), Gaps = 48/387 (12%)
Query: 93 ELNKCREENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLA 152
E+ C++ ++++LS I P + L L L + N + +P ++ L+ L
Sbjct: 459 EIKNCQK--IIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLE 516
Query: 153 LSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIK 212
LSEN L + +L L+ LDL N++++IP+ + + SL L L N+ T +++
Sbjct: 517 LSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELC 576
Query: 213 NLSKLSMLSIRENKIKQLPAEIG--------------------ELCNLITLD------VA 246
L L +L + EN+++++ ++I ELC L +L+ +
Sbjct: 577 TLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIK 636
Query: 247 HNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKC 306
+L LP E+ N TQ+ LD+ +N + ++P IG L +L L N++S +P SL
Sbjct: 637 GRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSL 696
Query: 307 SALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPV---GGPSQFSTIYSLNME 363
+ L++LNL NN++ LP S + ++ L + N PV G ++ L
Sbjct: 697 NDLQQLNLSGNNLTALP-SAIYNIFSLKEINFDDNPLLRPPVEICKGKQLYTIARYLQRA 755
Query: 364 HNRINKIPFGIFSRAK----------VLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQ 413
R KI IF + KLN+ +++ T +P S V L+ +Q
Sbjct: 756 DERDEKILEKIFKIVANNITETNFEFLCQKLNLANSE-TDMPT-----KSTVSLSERAHQ 809
Query: 414 LTKIPEDVSGLVSLEVLILSNNLLKKL 440
I + S +SL L + L++ L
Sbjct: 810 ALVIWKTQSNKLSLTAAALRDQLIRAL 836
Score = 111 bits (277), Expect = 2e-24
Identities = 89/345 (25%), Positives = 157/345 (45%), Gaps = 31/345 (8%)
Query: 82 RKKSSNAEVIKELNKCREE--NSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLP 139
RK N + ++ C N L+ S I +P IK ++ ++ L NK+ P
Sbjct: 421 RKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFP 480
Query: 140 AEVGCLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYL 199
+ L +L L+++ N ++ +P + K+L L+L NKL L +L L L
Sbjct: 481 LGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDL 540
Query: 200 RFNRITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGN 259
N+I + I N+ L +L + NK + P E+ L NL LD++ NQL+ + +I N
Sbjct: 541 GKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICN 600
Query: 260 CTQITNLDLQHNELLDLPDTIGNLSSLSRLG---LRYNRLSAIPRSLAKCSALEELNLEN 316
I L+ N+ + P + L SL +L ++ +L+ +P L+ + L+EL++ N
Sbjct: 601 LKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISN 660
Query: 317 NNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFS 376
N I +P ++ + + SL+ +N+I+ +P + S
Sbjct: 661 NAIREIPRNI-------------------------GELRNLVSLHAYNNQISYLPPSLLS 695
Query: 377 RAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDV 421
L +LN+ N LT+LP S+ E+N N L + P ++
Sbjct: 696 -LNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEI 739
>gi|95113664 leucine rich repeat containing 1 [Homo sapiens]
Length = 524
Score = 197 bits (502), Expect = 2e-50
Identities = 123/395 (31%), Positives = 205/395 (51%), Gaps = 28/395 (7%)
Query: 169 KKLRMLDLRHNKLREIPSVVYRLD-SLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKI 227
+ + +D RH L +P +YR SL L L N++ + + L KL L + +N+I
Sbjct: 12 RHVESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEI 71
Query: 228 KQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLS 287
++LP EI L+ LDV+ N++ +P+ I C + D N L LP++ L +L+
Sbjct: 72 QRLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLT 131
Query: 288 RLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYP 347
L + L ++P ++ L L L N ++ LP+SL
Sbjct: 132 CLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSL--------------------- 170
Query: 348 VGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVEL 407
+Q + L++ +N I +P I + L L + NQL+ LP + G +++ L
Sbjct: 171 ----TQLRRLEELDLGNNEIYNLPESIGALLH-LKDLWLDGNQLSELPQEIGNLKNLLCL 225
Query: 408 NLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEI 467
+++ N+L ++PE++SGL SL L++S NLL+ +P G+G L+KL L +++N+L LP +
Sbjct: 226 DVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAV 285
Query: 468 AYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDN 527
+ L +LVLT NQL TLP+ IG L L++L N L LP+EIG +L + DN
Sbjct: 286 GECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDN 345
Query: 528 PNLHSLPFELALCSKLSIMSIENCPLSHLPPQIVA 562
L +P E++ ++L ++ + L HLP + A
Sbjct: 346 -RLTRIPAEVSQATELHVLDVAGNRLLHLPLSLTA 379
Score = 182 bits (463), Expect = 6e-46
Identities = 129/421 (30%), Positives = 213/421 (50%), Gaps = 14/421 (3%)
Query: 105 LDLSKRSIHILPSSIKELTQ-LTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPD 163
+D S+ +P I + L EL L +N+L+ LP + LV L L LS+N + LP
Sbjct: 17 IDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPP 76
Query: 164 SLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIR 223
+ N +L LD+ N++ EIP + +L N +T + + L L+ LS+
Sbjct: 77 EIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVN 136
Query: 224 ENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNL 283
+ ++ LP IG L NL +L++ N L +LP + ++ LDL +NE+ +LP++IG L
Sbjct: 137 DISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGAL 196
Query: 284 SSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCF 343
L L L N+LS +P+ + L L++ N + LPE +S L L L +++N
Sbjct: 197 LHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEE-ISGLTSLTDLVISQNLL 255
Query: 344 QLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTS 403
+ P G + + L ++ NR+ ++P + + L++L + +NQL +LP G
Sbjct: 256 ETIP-DGIGKLKKLSILKVDQNRLTQLPEAV-GECESLTELVLTENQLLTLPKSIGKLKK 313
Query: 404 MVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESL 463
+ LN N+L +P+++ G SL V + +N L ++P + +L LD+ N+L L
Sbjct: 314 LSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHL 373
Query: 464 PNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLT-----HLPEEIGTLEN 518
P + LK L+ L L++NQ L + T+ T GE +LT LP E EN
Sbjct: 374 PLSLTALK-LKALWLSDNQSQPL---LTFQTD-TDYTTGEKILTCVLLPQLPSEPTCQEN 428
Query: 519 L 519
L
Sbjct: 429 L 429
Score = 163 bits (413), Expect = 4e-40
Identities = 127/413 (30%), Positives = 191/413 (46%), Gaps = 34/413 (8%)
Query: 104 RLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPD 163
+L LS I LP I QL EL + N++ +P + L S N LT LP+
Sbjct: 63 KLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPE 122
Query: 164 SLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIR 223
S L+ L L + L+ +P + L +L +L LR N +T + + L +L L +
Sbjct: 123 SFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLG 182
Query: 224 ENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNL 283
N+I LP IG L +L L + NQL LP+EIGN + LD+ N L LP+ I L
Sbjct: 183 NNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGL 242
Query: 284 SSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCF 343
+SL+ L + N L IP + K L L ++ N ++ LPE++
Sbjct: 243 TSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAV----------------- 285
Query: 344 QLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTS 403
+ ++ L + N++ +P I + K LS LN N+L SLP + G S
Sbjct: 286 --------GECESLTELVLTENQLLTLPKSI-GKLKKLSNLNADRNKLVSLPKEIGGCCS 336
Query: 404 MVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESL 463
+ + N+LT+IP +VS L VL ++ N L LP L L KL+ L L +N+ + L
Sbjct: 337 LTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPLSLTAL-KLKALWLSDNQSQPL 395
Query: 464 PNEIAYLKDLQ----KLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEE 512
+ + D + +LT L LP NL G ENL+ + +E
Sbjct: 396 ---LTFQTDTDYTTGEKILTCVLLPQLPSEPTCQENLPRCGALENLVNDVSDE 445
Score = 152 bits (385), Expect = 6e-37
Identities = 89/241 (36%), Positives = 139/241 (57%), Gaps = 2/241 (0%)
Query: 101 NSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTS 160
N L+L + + LP S+ +L +L EL L +N++ +LP +G L++L L L N L+
Sbjct: 152 NLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSE 211
Query: 161 LPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSML 220
LP + NLK L LD+ N+L +P + L SLT L + N + T+ I L KLS+L
Sbjct: 212 LPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSIL 271
Query: 221 SIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTI 280
+ +N++ QLP +GE +L L + NQL LPK IG +++NL+ N+L+ LP I
Sbjct: 272 KVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEI 331
Query: 281 GNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLAR 340
G SL+ +R NRL+ IP +++ + L L++ N + LP SL + +KL +L L+
Sbjct: 332 GGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPLSL--TALKLKALWLSD 389
Query: 341 N 341
N
Sbjct: 390 N 390
Score = 53.9 bits (128), Expect = 4e-07
Identities = 34/101 (33%), Positives = 53/101 (52%), Gaps = 6/101 (5%)
Query: 100 ENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLT 159
E+ L L++ + LP SI +L +L+ L NKL SLP E+G +L + +N LT
Sbjct: 289 ESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLT 348
Query: 160 SLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLR 200
+P + +L +LD+ N+L +P SLT L L+
Sbjct: 349 RIPAEVSQATELHVLDVAGNRLLHLPL------SLTALKLK 383
>gi|16904383 leucine rich repeat containing 7 [Homo sapiens]
Length = 1537
Score = 194 bits (494), Expect = 1e-49
Identities = 126/377 (33%), Positives = 198/377 (52%), Gaps = 5/377 (1%)
Query: 171 LRMLDLRHNKLREIPSVVYRLD-SLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQ 229
+ +LD H L+++P V+ + +L LYL N+I + K + N L LSI +N +
Sbjct: 24 ISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSN 83
Query: 230 LPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRL 289
LP I L NL LD++ N ++ P+ I C +T ++ N + LPD L +L++L
Sbjct: 84 LPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQL 143
Query: 290 GLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVG 349
L L +P + + L L L N++ TLP+S+ L +L L L N F P
Sbjct: 144 YLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSM-HKLAQLERLDLGNNEFGELPEV 202
Query: 350 GPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNL 409
Q + L M++N + +P G + K+L L+M N++ ++ +D ++ +L L
Sbjct: 203 -LDQIQNLRELWMDNNALQVLP-GSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLL 260
Query: 410 ATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAY 469
++N L ++P+ + L L L + +N L LP+ +GNL L E D N+LESLP+ I Y
Sbjct: 261 SSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGY 320
Query: 470 LKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNPN 529
L L+ L + N L LPR IG N+T + L N L LPEEIG ++ L L L+DN
Sbjct: 321 LHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDN-R 379
Query: 530 LHSLPFELALCSKLSIM 546
L +LPF +L+ +
Sbjct: 380 LKNLPFSFTKLKELAAL 396
Score = 166 bits (420), Expect = 5e-41
Identities = 114/388 (29%), Positives = 192/388 (49%), Gaps = 26/388 (6%)
Query: 99 EENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSL 158
E L L I LP + L +L + N L +LP + LVNL L +S+N +
Sbjct: 45 ERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGV 104
Query: 159 TSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLS 218
P+++ K L +++ N + ++P +L +LT LYL + + + L KL
Sbjct: 105 QEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLR 164
Query: 219 MLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPD 278
+L +REN +K LP + +L L LD+ +N+ LP+ + + L + +N L LP
Sbjct: 165 ILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPG 224
Query: 279 TIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTL 338
+IG L L L + NR+ + ++ C ALE+L L +N + LP+S + L KL +L +
Sbjct: 225 SIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDS-IGLLKKLTTLKV 283
Query: 339 ARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDF 398
N + P +TI +L++ L + + N+L SLP
Sbjct: 284 DDNQLTMLP-------NTIGNLSL------------------LEEFDCSCNELESLPSTI 318
Query: 399 GTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEEN 458
G S+ L + N L ++P ++ ++ V+ L +N L+ LP +G ++KLR L+L +N
Sbjct: 319 GYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDN 378
Query: 459 KLESLPNEIAYLKDLQKLVLTNNQLTTL 486
+L++LP LK+L L L++NQ L
Sbjct: 379 RLKNLPFSFTKLKELAALWLSDNQSKAL 406
Score = 141 bits (355), Expect = 2e-33
Identities = 106/345 (30%), Positives = 168/345 (48%), Gaps = 6/345 (1%)
Query: 101 NSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTS 160
N LD+SK + P +IK LT + N + LP L+NL L L++ L
Sbjct: 93 NLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEF 152
Query: 161 LPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSML 220
LP + L KLR+L+LR N L+ +P +++L L L L N + + + + L L
Sbjct: 153 LPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLREL 212
Query: 221 SIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTI 280
+ N ++ LP IG+L L+ LD++ N++E + +I C + +L L N L LPD+I
Sbjct: 213 WMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSI 272
Query: 281 GNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLAR 340
G L L+ L + N+L+ +P ++ S LEE + N + +LP S + L L +L +
Sbjct: 273 GLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLP-STIGYLHSLRTLAVDE 331
Query: 341 NCFQLYPVG-GPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFG 399
N P G + T+ SL N++ +P I K L LN+ DN+L +LP F
Sbjct: 332 NFLPELPREIGSCKNVTVMSL--RSNKLEFLPEEIGQMQK-LRVLNLSDNRLKNLPFSFT 388
Query: 400 TWTSMVELNLATNQ-LTKIPEDVSGLVSLEVLILSNNLLKKLPHG 443
+ L L+ NQ IP + +L+N + + P G
Sbjct: 389 KLKELAALWLSDNQSKALIPLQTEAHPETKQRVLTNYMFPQQPRG 433
Score = 35.4 bits (80), Expect = 0.15
Identities = 23/58 (39%), Positives = 33/58 (56%), Gaps = 2/58 (3%)
Query: 506 LTHLPEEIGTLEN-LEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLSHLPPQIVA 562
L +P+E+ E LEELYL+ N + LP +L C L +SI + LS+LP I +
Sbjct: 34 LQQVPKEVFNFERTLEELYLDAN-QIEELPKQLFNCQALRKLSIPDNDLSNLPTTIAS 90
>gi|122937315 leucine-rich repeats and IQ motif containing 4 [Homo
sapiens]
Length = 560
Score = 193 bits (491), Expect = 3e-49
Identities = 140/453 (30%), Positives = 227/453 (50%), Gaps = 33/453 (7%)
Query: 105 LDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDS 164
+D S +S+ +P I T+L E++L +N+++ +P E+ L N+ L L +N+L SL +
Sbjct: 30 IDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPA 89
Query: 165 LDNLKKLRMLDLRHN------------------------KLREIPSVVYR-LDSLTTLYL 199
L L L LDL +N L+EIP V+++ L L L L
Sbjct: 90 LGLLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGL 149
Query: 200 RFNRITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGN 259
N + + K+I N +KL + ++ N+ + P E+ L L +D+ N++ +P+EIG+
Sbjct: 150 TGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGH 209
Query: 260 CTQITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNI 319
T + + N L LP ++ S LS L L +N L +IP+S A+ + E+ L N +
Sbjct: 210 LTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRL 269
Query: 320 STLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQ-FSTIYSLNMEHNRINKIPFGIFSRA 378
+P L+ L+ L L L+ + G + + L++ N ++ P I +
Sbjct: 270 EKVPR-LICRWTSLHLLYLGNT--GLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICA-L 325
Query: 379 KVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNN--- 435
K L L + DN++ LP + G+ + + L L N+ PE+V L SLE L + +
Sbjct: 326 KNLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGF 385
Query: 436 LLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTN 495
L +P + L+ L+EL +E N LE LP + + +L+ L +N L LP I
Sbjct: 386 KLTYVPEHIRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQA 445
Query: 496 LTHLGLGENLLTHLPEEIGTLENLEELYLNDNP 528
L L L +NLLTHLPE + +L NL+ L L DNP
Sbjct: 446 LKELRLEDNLLTHLPENLDSLVNLKVLTLMDNP 478
Score = 138 bits (348), Expect = 1e-32
Identities = 93/320 (29%), Positives = 157/320 (49%), Gaps = 29/320 (9%)
Query: 105 LDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDS 164
+DL + I +P I LT L + Y+ SN L LPA + L L LS N L S+P S
Sbjct: 193 IDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKS 252
Query: 165 LDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRE 224
L+K+ + L N+L ++P ++ R SL LYL + + + L L L + +
Sbjct: 253 FAELRKMTEIGLSGNRLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQ 312
Query: 225 NKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLS 284
N + P +I L NL L + N++ LP E+G+ +++ L L NE L P+ + +L+
Sbjct: 313 NHLHHCPLQICALKNLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLA 372
Query: 285 SLSRLGLRYN---RLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARN 341
SL +L + + +L+ +P + K +L+EL +ENN++ LP SL
Sbjct: 373 SLEKLYIGQDQGFKLTYVPEHIRKLQSLKELYIENNHLEYLPVSL--------------- 417
Query: 342 CFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTW 401
+ L+ HN + ++P I +A+ L +L ++DN LT LP + +
Sbjct: 418 ----------GSMPNLEVLDCRHNLLKQLPDAI-CQAQALKELRLEDNLLTHLPENLDSL 466
Query: 402 TSMVELNLATNQLTKIPEDV 421
++ L L N + + P++V
Sbjct: 467 VNLKVLTLMDNPMEEPPKEV 486
Score = 123 bits (309), Expect = 4e-28
Identities = 110/394 (27%), Positives = 175/394 (44%), Gaps = 36/394 (9%)
Query: 174 LDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLPAE 233
+D + L IP ++ L ++L N+I + ++I+ L + +L + +N ++ L
Sbjct: 30 IDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPA 89
Query: 234 IGELCNLITLDVAHNQLEHLPKEIGNCTQ-ITNLDLQHNELLDLPDTI-GNLSSLSRLGL 291
+G L +L +LD+++N + + + + L L +L ++P I NL L LGL
Sbjct: 90 LGLLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGL 149
Query: 292 RYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYP--VG 349
N L +P+ + + L E+ L+ N P+ L L L + L N P +G
Sbjct: 150 TGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCV-LYTLEIIDLDENKIGAIPEEIG 208
Query: 350 GPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNL 409
+ Y M N + +P + + LS L++ N L S+P F M E+ L
Sbjct: 209 HLTGLQKFY---MASNNLPVLPASL-CQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGL 264
Query: 410 ATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAY 469
+ N+L K+P + SL +L L N L +L L LR LDL +N L P +I
Sbjct: 265 SGNRLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICA 324
Query: 470 LKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNPN 529
LK NL LGL +N + LP E+G+L L+ L L N
Sbjct: 325 LK-----------------------NLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEF 361
Query: 530 LHSLPFE---LALCSKLSIMSIENCPLSHLPPQI 560
L S P E LA KL I + L+++P I
Sbjct: 362 L-SFPEEVLSLASLEKLYIGQDQGFKLTYVPEHI 394
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 193 bits (490), Expect = 4e-49
Identities = 131/390 (33%), Positives = 200/390 (51%), Gaps = 28/390 (7%)
Query: 169 KKLRMLDLRHNKLREIPSVVYRLD-SLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKI 227
+ + +D RH L+ +P +YR SL L L N++ + K L L L + +N+I
Sbjct: 12 RHVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEI 71
Query: 228 KQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLS 287
++LP E+ L+ LDV+ N + +P+ I C + D N L LPD L SL+
Sbjct: 72 QRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLA 131
Query: 288 RLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYP 347
L L L A+P + + L L L N + +LP SL S LVKL L L N ++ P
Sbjct: 132 HLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASL-SFLVKLEQLDLGGNDLEVLP 190
Query: 348 VGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVEL 407
+ + +P L +L + NQL++LP + G +V L
Sbjct: 191 -----------------DTLGALPN--------LRELWLDRNQLSALPPELGNLRRLVCL 225
Query: 408 NLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEI 467
+++ N+L ++P ++ GLV L L+LS NLL++LP G+G L++L L +++N+L + I
Sbjct: 226 DVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAI 285
Query: 468 AYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDN 527
++L +L+LT N L LPR +G LT LT+L + N L LP EIG L L L DN
Sbjct: 286 GDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDN 345
Query: 528 PNLHSLPFELALCSKLSIMSIENCPLSHLP 557
L LP ELA ++L ++ + L LP
Sbjct: 346 -RLAVLPPELAHTTELHVLDVAGNRLQSLP 374
Score = 183 bits (464), Expect = 4e-46
Identities = 124/379 (32%), Positives = 197/379 (51%), Gaps = 5/379 (1%)
Query: 111 SIHILPSSIKELTQ-LTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDSLDNLK 169
S+ +P I ++ L EL L +N+L+ LP L+NL L LS+N + LP + N
Sbjct: 23 SLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFM 82
Query: 170 KLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQ 229
+L LD+ N + EIP + +L N ++ + L L+ L++ + ++
Sbjct: 83 QLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQA 142
Query: 230 LPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRL 289
LP ++G L NL+TL++ N L+ LP + ++ LDL N+L LPDT+G L +L L
Sbjct: 143 LPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLREL 202
Query: 290 GLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVG 349
L N+LSA+P L L L++ N + LP L LV L L L++N + P
Sbjct: 203 WLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAE-LGGLVLLTDLLLSQNLLRRLP-D 260
Query: 350 GPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNL 409
G Q + L ++ NR+ ++ I + LS+L + +N L +LP G T + LN+
Sbjct: 261 GIGQLKQLSILKVDQNRLCEVTEAI-GDCENLSELILTENLLMALPRSLGKLTKLTNLNV 319
Query: 410 ATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAY 469
N L +P ++ G V+L VL L +N L LP L + +L LD+ N+L+SLP + +
Sbjct: 320 DRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTH 379
Query: 470 LKDLQKLVLTNNQLTTLPR 488
L +L+ L L NQ + R
Sbjct: 380 L-NLKALWLAENQAQPMLR 397
Score = 157 bits (397), Expect = 3e-38
Identities = 101/282 (35%), Positives = 153/282 (54%), Gaps = 9/282 (3%)
Query: 106 DLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDSL 165
D S + LP +L L L L LQ+LP +VG L NL+TL L EN L SLP SL
Sbjct: 111 DFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASL 170
Query: 166 DNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIREN 225
L KL LDL N L +P + L +L L+L N+++ + ++ NL +L L + EN
Sbjct: 171 SFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSEN 230
Query: 226 KIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSS 285
++++LPAE+G L L L ++ N L LP IG Q++ L + N L ++ + IG+ +
Sbjct: 231 RLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCEN 290
Query: 286 LSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQL 345
LS L L N L A+PRSL K + L LN++ N++ LP + V L+ L+L N +
Sbjct: 291 LSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPE-IGGCVALSVLSLRDNRLAV 349
Query: 346 YPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMK 387
P + + ++ L++ NR+ +PF L+ LN+K
Sbjct: 350 LP-PELAHTTELHVLDVAGNRLQSLPF-------ALTHLNLK 383
Score = 141 bits (356), Expect = 1e-33
Identities = 88/241 (36%), Positives = 137/241 (56%), Gaps = 2/241 (0%)
Query: 101 NSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTS 160
N + L+L + + LP+S+ L +L +L L N L+ LP +G L NL L L N L++
Sbjct: 152 NLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSA 211
Query: 161 LPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSML 220
LP L NL++L LD+ N+L E+P+ + L LT L L N + + I L +LS+L
Sbjct: 212 LPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSIL 271
Query: 221 SIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTI 280
+ +N++ ++ IG+ NL L + N L LP+ +G T++TNL++ N L LP I
Sbjct: 272 KVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEI 331
Query: 281 GNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLAR 340
G +LS L LR NRL+ +P LA + L L++ N + +LP +L + + L +L LA
Sbjct: 332 GGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFAL--THLNLKALWLAE 389
Query: 341 N 341
N
Sbjct: 390 N 390
Score = 139 bits (350), Expect = 7e-33
Identities = 106/351 (30%), Positives = 169/351 (48%), Gaps = 6/351 (1%)
Query: 87 NAEVIKELNK--CREENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGC 144
+A ++EL K R N +L LS I LP + QL EL + N + +P +
Sbjct: 44 DANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKF 103
Query: 145 LVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRI 204
L S N L+ LPD L+ L L L L+ +P V L +L TL LR N +
Sbjct: 104 CKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLL 163
Query: 205 TTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQIT 264
++ + L KL L + N ++ LP +G L NL L + NQL LP E+GN ++
Sbjct: 164 KSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLV 223
Query: 265 NLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPE 324
LD+ N L +LP +G L L+ L L N L +P + + L L ++ N + + E
Sbjct: 224 CLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTE 283
Query: 325 SLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKL 384
+ + L+ L L N P + + + +LN++ N + +P I LS L
Sbjct: 284 A-IGDCENLSELILTENLLMALP-RSLGKLTKLTNLNVDRNHLEALPPEI-GGCVALSVL 340
Query: 385 NMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNN 435
+++DN+L LP + T + L++A N+L +P ++ L +L+ L L+ N
Sbjct: 341 SLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTHL-NLKALWLAEN 390
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 193 bits (490), Expect = 4e-49
Identities = 131/390 (33%), Positives = 200/390 (51%), Gaps = 28/390 (7%)
Query: 169 KKLRMLDLRHNKLREIPSVVYRLD-SLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKI 227
+ + +D RH L+ +P +YR SL L L N++ + K L L L + +N+I
Sbjct: 12 RHVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEI 71
Query: 228 KQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLS 287
++LP E+ L+ LDV+ N + +P+ I C + D N L LPD L SL+
Sbjct: 72 QRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLA 131
Query: 288 RLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYP 347
L L L A+P + + L L L N + +LP SL S LVKL L L N ++ P
Sbjct: 132 HLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASL-SFLVKLEQLDLGGNDLEVLP 190
Query: 348 VGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVEL 407
+ + +P L +L + NQL++LP + G +V L
Sbjct: 191 -----------------DTLGALPN--------LRELWLDRNQLSALPPELGNLRRLVCL 225
Query: 408 NLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEI 467
+++ N+L ++P ++ GLV L L+LS NLL++LP G+G L++L L +++N+L + I
Sbjct: 226 DVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAI 285
Query: 468 AYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDN 527
++L +L+LT N L LPR +G LT LT+L + N L LP EIG L L L DN
Sbjct: 286 GDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDN 345
Query: 528 PNLHSLPFELALCSKLSIMSIENCPLSHLP 557
L LP ELA ++L ++ + L LP
Sbjct: 346 -RLAVLPPELAHTTELHVLDVAGNRLQSLP 374
Score = 183 bits (464), Expect = 4e-46
Identities = 124/379 (32%), Positives = 197/379 (51%), Gaps = 5/379 (1%)
Query: 111 SIHILPSSIKELTQ-LTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDSLDNLK 169
S+ +P I ++ L EL L +N+L+ LP L+NL L LS+N + LP + N
Sbjct: 23 SLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFM 82
Query: 170 KLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQ 229
+L LD+ N + EIP + +L N ++ + L L+ L++ + ++
Sbjct: 83 QLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQA 142
Query: 230 LPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRL 289
LP ++G L NL+TL++ N L+ LP + ++ LDL N+L LPDT+G L +L L
Sbjct: 143 LPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLREL 202
Query: 290 GLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVG 349
L N+LSA+P L L L++ N + LP L LV L L L++N + P
Sbjct: 203 WLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAE-LGGLVLLTDLLLSQNLLRRLP-D 260
Query: 350 GPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNL 409
G Q + L ++ NR+ ++ I + LS+L + +N L +LP G T + LN+
Sbjct: 261 GIGQLKQLSILKVDQNRLCEVTEAI-GDCENLSELILTENLLMALPRSLGKLTKLTNLNV 319
Query: 410 ATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAY 469
N L +P ++ G V+L VL L +N L LP L + +L LD+ N+L+SLP + +
Sbjct: 320 DRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTH 379
Query: 470 LKDLQKLVLTNNQLTTLPR 488
L +L+ L L NQ + R
Sbjct: 380 L-NLKALWLAENQAQPMLR 397
Score = 157 bits (397), Expect = 3e-38
Identities = 101/282 (35%), Positives = 153/282 (54%), Gaps = 9/282 (3%)
Query: 106 DLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDSL 165
D S + LP +L L L L LQ+LP +VG L NL+TL L EN L SLP SL
Sbjct: 111 DFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASL 170
Query: 166 DNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIREN 225
L KL LDL N L +P + L +L L+L N+++ + ++ NL +L L + EN
Sbjct: 171 SFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSEN 230
Query: 226 KIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSS 285
++++LPAE+G L L L ++ N L LP IG Q++ L + N L ++ + IG+ +
Sbjct: 231 RLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCEN 290
Query: 286 LSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQL 345
LS L L N L A+PRSL K + L LN++ N++ LP + V L+ L+L N +
Sbjct: 291 LSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPE-IGGCVALSVLSLRDNRLAV 349
Query: 346 YPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMK 387
P + + ++ L++ NR+ +PF L+ LN+K
Sbjct: 350 LP-PELAHTTELHVLDVAGNRLQSLPF-------ALTHLNLK 383
Score = 141 bits (356), Expect = 1e-33
Identities = 88/241 (36%), Positives = 137/241 (56%), Gaps = 2/241 (0%)
Query: 101 NSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTS 160
N + L+L + + LP+S+ L +L +L L N L+ LP +G L NL L L N L++
Sbjct: 152 NLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSA 211
Query: 161 LPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSML 220
LP L NL++L LD+ N+L E+P+ + L LT L L N + + I L +LS+L
Sbjct: 212 LPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSIL 271
Query: 221 SIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTI 280
+ +N++ ++ IG+ NL L + N L LP+ +G T++TNL++ N L LP I
Sbjct: 272 KVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEI 331
Query: 281 GNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLAR 340
G +LS L LR NRL+ +P LA + L L++ N + +LP +L + + L +L LA
Sbjct: 332 GGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFAL--THLNLKALWLAE 389
Query: 341 N 341
N
Sbjct: 390 N 390
Score = 139 bits (350), Expect = 7e-33
Identities = 106/351 (30%), Positives = 169/351 (48%), Gaps = 6/351 (1%)
Query: 87 NAEVIKELNK--CREENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGC 144
+A ++EL K R N +L LS I LP + QL EL + N + +P +
Sbjct: 44 DANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKF 103
Query: 145 LVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRI 204
L S N L+ LPD L+ L L L L+ +P V L +L TL LR N +
Sbjct: 104 CKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLL 163
Query: 205 TTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQIT 264
++ + L KL L + N ++ LP +G L NL L + NQL LP E+GN ++
Sbjct: 164 KSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLV 223
Query: 265 NLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPE 324
LD+ N L +LP +G L L+ L L N L +P + + L L ++ N + + E
Sbjct: 224 CLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTE 283
Query: 325 SLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKL 384
+ + L+ L L N P + + + +LN++ N + +P I LS L
Sbjct: 284 A-IGDCENLSELILTENLLMALP-RSLGKLTKLTNLNVDRNHLEALPPEI-GGCVALSVL 340
Query: 385 NMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNN 435
+++DN+L LP + T + L++A N+L +P ++ L +L+ L L+ N
Sbjct: 341 SLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTHL-NLKALWLAEN 390
>gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]
Length = 1302
Score = 184 bits (467), Expect = 2e-46
Identities = 127/407 (31%), Positives = 201/407 (49%), Gaps = 27/407 (6%)
Query: 99 EENSMRLDLSKRSIHILPSSIKELTQ-LTELYLYSNKLQSLPAEVGCLVNLMTLALSENS 157
EE LD S S+ +P I + L ELYL +N+++ LP ++ +L L+L +N
Sbjct: 21 EETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDND 80
Query: 158 LTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKL 217
LT+LP S+ NL LR LD+ N ++E P + LT + N I+ + L L
Sbjct: 81 LTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNL 140
Query: 218 SMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLP 277
+ L + + ++ LPA G L L L++ NQL+ LPK + TQ+ LDL NE ++P
Sbjct: 141 TQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVP 200
Query: 278 DTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLT 337
+ + LS L + NRL+ IP + L L++ NNI + E +S+ L L
Sbjct: 201 EVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEG-ISTCENLQDLL 259
Query: 338 LARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLD 397
L+ N Q P TI SL K ++ L + +NQL LP
Sbjct: 260 LSSNSLQQLP-------ETIGSL------------------KNITTLKIDENQLMYLPDS 294
Query: 398 FGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEE 457
G S+ EL+ + N++ +P + L +L +N L++LP +G+ + + L L
Sbjct: 295 IGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHS 354
Query: 458 NKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGEN 504
NKLE+LP E+ ++ L+ + L++N+L LP L LT + L +N
Sbjct: 355 NKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDN 401
Score = 177 bits (450), Expect = 2e-44
Identities = 115/385 (29%), Positives = 195/385 (50%), Gaps = 28/385 (7%)
Query: 174 LDLRHNKLREIPSVVYRLD-SLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLPA 232
LD H L ++P ++ + +L LYL N+I + K + N L LS+ +N + LPA
Sbjct: 27 LDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPA 86
Query: 233 EIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRLGLR 292
I L NL LDV+ N ++ P+ I NC +T ++ N + LPD L +L++L L
Sbjct: 87 SIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLN 146
Query: 293 YNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPS 352
L +P + + + L+ L L N + LP+++ + L +L L L N F P
Sbjct: 147 DAFLEFLPANFGRLTKLQILELRENQLKMLPKTM-NRLTQLERLDLGSNEFTEVPE---- 201
Query: 353 QFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATN 412
+ + L + M N+LT +P G+ + L+++ N
Sbjct: 202 ---------------------VLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN 240
Query: 413 QLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKD 472
+ + E +S +L+ L+LS+N L++LP +G+L+ + L ++EN+L LP+ I L
Sbjct: 241 NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLIS 300
Query: 473 LQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHS 532
+++L + N++ LP IG LTNL N L LP EIG+ +N+ L+L+ N L +
Sbjct: 301 VEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSN-KLET 359
Query: 533 LPFELALCSKLSIMSIENCPLSHLP 557
LP E+ KL ++++ + L +LP
Sbjct: 360 LPEEMGDMQKLKVINLSDNRLKNLP 384
Score = 154 bits (388), Expect = 3e-37
Identities = 106/327 (32%), Positives = 172/327 (52%), Gaps = 5/327 (1%)
Query: 235 GELCNLITLDVAHNQLEHLPKEIGNCTQ-ITNLDLQHNELLDLPDTIGNLSSLSRLGLRY 293
GE + TLD +H LE +PKEI + + L L N++ +LP + N SL +L L
Sbjct: 19 GEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPD 78
Query: 294 NRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQ 353
N L+ +P S+A L EL++ N I PE++ + V L + + N P G SQ
Sbjct: 79 NDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKV-LTIVEASVNPISKLP-DGFSQ 136
Query: 354 FSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQ 413
+ L + + +P F R L L +++NQL LP T + L+L +N+
Sbjct: 137 LLNLTQLYLNDAFLEFLPAN-FGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNE 195
Query: 414 LTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDL 473
T++PE + L L+ + N L +P +G+L++L LD+ +N +E + I+ ++L
Sbjct: 196 FTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENL 255
Query: 474 QKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSL 533
Q L+L++N L LP IG L N+T L + EN L +LP+ IG L ++EEL + N + +L
Sbjct: 256 QDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFN-EVEAL 314
Query: 534 PFELALCSKLSIMSIENCPLSHLPPQI 560
P + + L + ++ L LPP+I
Sbjct: 315 PSSIGQLTNLRTFAADHNYLQQLPPEI 341
Score = 147 bits (372), Expect = 2e-35
Identities = 111/388 (28%), Positives = 178/388 (45%), Gaps = 48/388 (12%)
Query: 101 NSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTS 160
N LD+SK I P +IK LT + N + LP L+NL L L++ L
Sbjct: 93 NLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEF 152
Query: 161 LPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSML 220
LP + L KL++L+LR N+L+ +P + RL L L L N T V + ++ LS L
Sbjct: 153 LPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEF 212
Query: 221 SIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTI 280
+ N++ +P IG L L LDV+ N +E + + I C + +L L N L LP+TI
Sbjct: 213 WMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETI 272
Query: 281 GNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLAR 340
G+L +++ L + N+L +P S+ ++EEL+ N + LP S+
Sbjct: 273 GSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSI-------------- 318
Query: 341 NCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGT 400
Q + + + +HN + ++P I S K ++ L + N+L +LP + G
Sbjct: 319 -----------GQLTNLRTFAADHNYLQQLPPEIGS-WKNITVLFLHSNKLETLPEEMGD 366
Query: 401 WTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKL 460
+ +NL+ N+L +P + L L + LS+N K L
Sbjct: 367 MQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPL-------------------- 406
Query: 461 ESLPNEIAYLKDLQKLVLTNNQLTTLPR 488
+P + + QK+VLTN PR
Sbjct: 407 --IPLQKETDSETQKMVLTNYMFPQQPR 432
Score = 146 bits (368), Expect = 6e-35
Identities = 101/322 (31%), Positives = 162/322 (50%), Gaps = 10/322 (3%)
Query: 105 LDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDS 164
++ S I LP +L LT+LYL L+ LPA G L L L L EN L LP +
Sbjct: 120 VEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKT 179
Query: 165 LDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRE 224
++ L +L LDL N+ E+P V+ +L L ++ NR+T + I +L +L+ L + +
Sbjct: 180 MNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSK 239
Query: 225 NKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLS 284
N I+ + I NL L ++ N L+ LP+ IG+ IT L + N+L+ LPD+IG L
Sbjct: 240 NNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLI 299
Query: 285 SLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQ 344
S+ L +N + A+P S+ + + L ++N + LP + S + L L N +
Sbjct: 300 SVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPE-IGSWKNITVLFLHSNKLE 358
Query: 345 LYP--VGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSL-PLDFGTW 401
P +G + I N+ NR+ +PF F++ + L+ + + DNQ L PL T
Sbjct: 359 TLPEEMGDMQKLKVI---NLSDNRLKNLPFS-FTKLQQLTAMWLSDNQSKPLIPLQKETD 414
Query: 402 TSMVELNLATNQLTKIP--EDV 421
+ ++ L + P EDV
Sbjct: 415 SETQKMVLTNYMFPQQPRTEDV 436
Score = 90.5 bits (223), Expect = 4e-18
Identities = 56/181 (30%), Positives = 101/181 (55%), Gaps = 6/181 (3%)
Query: 86 SNAEVIKE-LNKCREENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGC 144
+N E+++E ++ C EN L LS S+ LP +I L +T L + N+L LP +G
Sbjct: 240 NNIEMVEEGISTC--ENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGG 297
Query: 145 LVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRI 204
L+++ L S N + +LP S+ L LR HN L+++P + ++T L+L N++
Sbjct: 298 LISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKL 357
Query: 205 TTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQ---LEHLPKEIGNCT 261
T+ +++ ++ KL ++++ +N++K LP +L L + ++ NQ L L KE + T
Sbjct: 358 ETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSET 417
Query: 262 Q 262
Q
Sbjct: 418 Q 418
>gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]
Length = 1371
Score = 184 bits (467), Expect = 2e-46
Identities = 127/407 (31%), Positives = 201/407 (49%), Gaps = 27/407 (6%)
Query: 99 EENSMRLDLSKRSIHILPSSIKELTQ-LTELYLYSNKLQSLPAEVGCLVNLMTLALSENS 157
EE LD S S+ +P I + L ELYL +N+++ LP ++ +L L+L +N
Sbjct: 21 EETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDND 80
Query: 158 LTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKL 217
LT+LP S+ NL LR LD+ N ++E P + LT + N I+ + L L
Sbjct: 81 LTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNL 140
Query: 218 SMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLP 277
+ L + + ++ LPA G L L L++ NQL+ LPK + TQ+ LDL NE ++P
Sbjct: 141 TQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVP 200
Query: 278 DTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLT 337
+ + LS L + NRL+ IP + L L++ NNI + E +S+ L L
Sbjct: 201 EVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEG-ISTCENLQDLL 259
Query: 338 LARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLD 397
L+ N Q P TI SL K ++ L + +NQL LP
Sbjct: 260 LSSNSLQQLP-------ETIGSL------------------KNITTLKIDENQLMYLPDS 294
Query: 398 FGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEE 457
G S+ EL+ + N++ +P + L +L +N L++LP +G+ + + L L
Sbjct: 295 IGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHS 354
Query: 458 NKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGEN 504
NKLE+LP E+ ++ L+ + L++N+L LP L LT + L +N
Sbjct: 355 NKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDN 401
Score = 177 bits (450), Expect = 2e-44
Identities = 115/385 (29%), Positives = 195/385 (50%), Gaps = 28/385 (7%)
Query: 174 LDLRHNKLREIPSVVYRLD-SLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLPA 232
LD H L ++P ++ + +L LYL N+I + K + N L LS+ +N + LPA
Sbjct: 27 LDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPA 86
Query: 233 EIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRLGLR 292
I L NL LDV+ N ++ P+ I NC +T ++ N + LPD L +L++L L
Sbjct: 87 SIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLN 146
Query: 293 YNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPS 352
L +P + + + L+ L L N + LP+++ + L +L L L N F P
Sbjct: 147 DAFLEFLPANFGRLTKLQILELRENQLKMLPKTM-NRLTQLERLDLGSNEFTEVPE---- 201
Query: 353 QFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATN 412
+ + L + M N+LT +P G+ + L+++ N
Sbjct: 202 ---------------------VLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN 240
Query: 413 QLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKD 472
+ + E +S +L+ L+LS+N L++LP +G+L+ + L ++EN+L LP+ I L
Sbjct: 241 NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLIS 300
Query: 473 LQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHS 532
+++L + N++ LP IG LTNL N L LP EIG+ +N+ L+L+ N L +
Sbjct: 301 VEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSN-KLET 359
Query: 533 LPFELALCSKLSIMSIENCPLSHLP 557
LP E+ KL ++++ + L +LP
Sbjct: 360 LPEEMGDMQKLKVINLSDNRLKNLP 384
Score = 154 bits (388), Expect = 3e-37
Identities = 106/327 (32%), Positives = 172/327 (52%), Gaps = 5/327 (1%)
Query: 235 GELCNLITLDVAHNQLEHLPKEIGNCTQ-ITNLDLQHNELLDLPDTIGNLSSLSRLGLRY 293
GE + TLD +H LE +PKEI + + L L N++ +LP + N SL +L L
Sbjct: 19 GEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPD 78
Query: 294 NRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQ 353
N L+ +P S+A L EL++ N I PE++ + V L + + N P G SQ
Sbjct: 79 NDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKV-LTIVEASVNPISKLP-DGFSQ 136
Query: 354 FSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQ 413
+ L + + +P F R L L +++NQL LP T + L+L +N+
Sbjct: 137 LLNLTQLYLNDAFLEFLPAN-FGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNE 195
Query: 414 LTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDL 473
T++PE + L L+ + N L +P +G+L++L LD+ +N +E + I+ ++L
Sbjct: 196 FTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENL 255
Query: 474 QKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSL 533
Q L+L++N L LP IG L N+T L + EN L +LP+ IG L ++EEL + N + +L
Sbjct: 256 QDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFN-EVEAL 314
Query: 534 PFELALCSKLSIMSIENCPLSHLPPQI 560
P + + L + ++ L LPP+I
Sbjct: 315 PSSIGQLTNLRTFAADHNYLQQLPPEI 341
Score = 147 bits (372), Expect = 2e-35
Identities = 111/388 (28%), Positives = 178/388 (45%), Gaps = 48/388 (12%)
Query: 101 NSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTS 160
N LD+SK I P +IK LT + N + LP L+NL L L++ L
Sbjct: 93 NLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEF 152
Query: 161 LPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSML 220
LP + L KL++L+LR N+L+ +P + RL L L L N T V + ++ LS L
Sbjct: 153 LPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEF 212
Query: 221 SIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTI 280
+ N++ +P IG L L LDV+ N +E + + I C + +L L N L LP+TI
Sbjct: 213 WMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETI 272
Query: 281 GNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLAR 340
G+L +++ L + N+L +P S+ ++EEL+ N + LP S+
Sbjct: 273 GSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSI-------------- 318
Query: 341 NCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGT 400
Q + + + +HN + ++P I S K ++ L + N+L +LP + G
Sbjct: 319 -----------GQLTNLRTFAADHNYLQQLPPEIGS-WKNITVLFLHSNKLETLPEEMGD 366
Query: 401 WTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKL 460
+ +NL+ N+L +P + L L + LS+N K L
Sbjct: 367 MQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPL-------------------- 406
Query: 461 ESLPNEIAYLKDLQKLVLTNNQLTTLPR 488
+P + + QK+VLTN PR
Sbjct: 407 --IPLQKETDSETQKMVLTNYMFPQQPR 432
Score = 146 bits (368), Expect = 6e-35
Identities = 101/322 (31%), Positives = 162/322 (50%), Gaps = 10/322 (3%)
Query: 105 LDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDS 164
++ S I LP +L LT+LYL L+ LPA G L L L L EN L LP +
Sbjct: 120 VEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKT 179
Query: 165 LDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRE 224
++ L +L LDL N+ E+P V+ +L L ++ NR+T + I +L +L+ L + +
Sbjct: 180 MNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSK 239
Query: 225 NKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLS 284
N I+ + I NL L ++ N L+ LP+ IG+ IT L + N+L+ LPD+IG L
Sbjct: 240 NNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLI 299
Query: 285 SLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQ 344
S+ L +N + A+P S+ + + L ++N + LP + S + L L N +
Sbjct: 300 SVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPE-IGSWKNITVLFLHSNKLE 358
Query: 345 LYP--VGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSL-PLDFGTW 401
P +G + I N+ NR+ +PF F++ + L+ + + DNQ L PL T
Sbjct: 359 TLPEEMGDMQKLKVI---NLSDNRLKNLPFS-FTKLQQLTAMWLSDNQSKPLIPLQKETD 414
Query: 402 TSMVELNLATNQLTKIP--EDV 421
+ ++ L + P EDV
Sbjct: 415 SETQKMVLTNYMFPQQPRTEDV 436
Score = 90.5 bits (223), Expect = 4e-18
Identities = 56/181 (30%), Positives = 101/181 (55%), Gaps = 6/181 (3%)
Query: 86 SNAEVIKE-LNKCREENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGC 144
+N E+++E ++ C EN L LS S+ LP +I L +T L + N+L LP +G
Sbjct: 240 NNIEMVEEGISTC--ENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGG 297
Query: 145 LVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRI 204
L+++ L S N + +LP S+ L LR HN L+++P + ++T L+L N++
Sbjct: 298 LISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKL 357
Query: 205 TTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQ---LEHLPKEIGNCT 261
T+ +++ ++ KL ++++ +N++K LP +L L + ++ NQ L L KE + T
Sbjct: 358 ETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSET 417
Query: 262 Q 262
Q
Sbjct: 418 Q 418
>gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
Length = 602
Score = 180 bits (457), Expect = 3e-45
Identities = 144/491 (29%), Positives = 233/491 (47%), Gaps = 66/491 (13%)
Query: 104 RLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPD 163
+L +S + L ++ L LT L ++ N+L SLP+ + L NL L +S N L LP+
Sbjct: 86 KLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPE 145
Query: 164 SLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIR 223
+ NL+ L+ L L+HN+L I +L +L L L N +TTV +LS L L++
Sbjct: 146 EITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLS 205
Query: 224 ENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLP------ 277
N++K LPAEI + L LD N LE +P E+ + L L+ N+L LP
Sbjct: 206 SNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPEFPSCS 265
Query: 278 -----------------DTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNIS 320
+ + +L+S+ L LR N+L ++P + +LE L+L NN+IS
Sbjct: 266 LLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDIS 325
Query: 321 TLPESLLSSLVKLNSL------TLARNCF------------QLYPVGGPSQ--------- 353
+LP SL + +K +L T+ R GPSQ
Sbjct: 326 SLPYSLGNLHLKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQSESATETAM 385
Query: 354 ------------FSTIYSLNMEHNRINKIPFGIFSRAK--VLSKLNMKDNQLTSLPLDFG 399
T+ L+ + IP +F K +++ +N NQL +P
Sbjct: 386 TLPSESRVNIHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMV 445
Query: 400 TWTSMV-ELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEEN 458
MV +++L+ N+L+ I ++ L L L L NN L LP + +L +L+ ++L N
Sbjct: 446 ELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFN 505
Query: 459 KLESLPNEIAYLKDLQKLVLTNNQLTTL-PRGIGHLTNLTHLGLGENLLTHLPEEIGTLE 517
+ + LP + + L+ ++++NNQ+ ++ P+ + + NLT L L N L +P E+G
Sbjct: 506 RFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCV 565
Query: 518 NLEELYLNDNP 528
NL L L+ NP
Sbjct: 566 NLRTLLLDGNP 576
Score = 172 bits (437), Expect = 6e-43
Identities = 132/484 (27%), Positives = 233/484 (48%), Gaps = 46/484 (9%)
Query: 121 ELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNK 180
E T LT+L + +NKLQSL ++ L L L + +N LTSLP ++ L+ L+ L++ HNK
Sbjct: 80 EQTDLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNK 139
Query: 181 LREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNL 240
L+ +P + L +L LYL+ N +T + + + LS L L + N + +PA L +L
Sbjct: 140 LKILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSL 199
Query: 241 ITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIP 300
+ L+++ N+L+ LP EI ++ +LD N L +P + + SL L LR N+L +P
Sbjct: 200 VRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLP 259
Query: 301 RSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSL 360
CS L+EL++ N I L L L + L L N + P ++ L
Sbjct: 260 E-FPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVP-DEIILLRSLERL 317
Query: 361 NMEHNRINKIPFGIFS----------------RAKVLSK----------LNMKDN----- 389
++ +N I+ +P+ + + R +++SK +KD+
Sbjct: 318 DLSNNDISSLPYSLGNLHLKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQS 377
Query: 390 -----QLTSLP----LDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLI---LSNNLL 437
+LP ++ ++ L+ + Q T IP++V V ++ S N L
Sbjct: 378 ESATETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQL 437
Query: 438 KKLPHGLGNLRKL-RELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNL 496
++P + L+++ ++DL NKL + E+ L+ L L L NN L +LP + L L
Sbjct: 438 CEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRL 497
Query: 497 THLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLSHL 556
+ L N LPE + + LE + +++N P ++ + L+ + ++N L +
Sbjct: 498 QTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQI 557
Query: 557 PPQI 560
PP++
Sbjct: 558 PPEL 561
Score = 102 bits (255), Expect = 7e-22
Identities = 100/385 (25%), Positives = 173/385 (44%), Gaps = 74/385 (19%)
Query: 98 REENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENS 157
R + LD + + +P + + L LYL NKL+ LP C + L L + EN
Sbjct: 218 RMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPEFPSCSL-LKELHVGENQ 276
Query: 158 LTSL-PDSLDNLKKLRMLDLRHNKLREIPSVVY------RLD-----------SLTTLYL 199
+ L + L +L + +LDLR NKL+ +P + RLD SL L+L
Sbjct: 277 IEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNLHL 336
Query: 200 RF-----NRITTVEKDIKNLSKLSMLSIRENKIKQ---------------LPAE----IG 235
+F N + T+ ++I + +L +KIK LP+E I
Sbjct: 337 KFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQSESATETAMTLPSESRVNIH 396
Query: 236 ELCNLITLDVAHNQLEHLPKEIGNCTQ---ITNLDLQHNELLDLPDTIGNLSSL-SRLGL 291
+ L LD + Q +P E+ + + +T+++ N+L ++P + L + S + L
Sbjct: 397 AIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDL 456
Query: 292 RYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGP 351
+N+LS I L L L+L NN +++LPE + SLV+L ++ L+ N F++ P
Sbjct: 457 SFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEE-MESLVRLQTINLSFNRFKMLP---- 511
Query: 352 SQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSL-PLDFGTWTSMVELNLA 410
++ + IF+ +L + +NQ+ S+ P ++ L+L
Sbjct: 512 -----------------EVLYRIFTLETIL----ISNNQVGSVDPQKMKMMENLTTLDLQ 550
Query: 411 TNQLTKIPEDVSGLVSLEVLILSNN 435
N L +IP ++ V+L L+L N
Sbjct: 551 NNDLLQIPPELGNCVNLRTLLLDGN 575
Score = 47.8 bits (112), Expect = 3e-05
Identities = 32/110 (29%), Positives = 55/110 (50%), Gaps = 1/110 (0%)
Query: 94 LNKCREENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLAL 153
L C + LDL ++ LP ++ L +L + L N+ + LP + + L T+ +
Sbjct: 466 LELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILI 525
Query: 154 SENSLTSL-PDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFN 202
S N + S+ P + ++ L LDL++N L +IP + +L TL L N
Sbjct: 526 SNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGN 575
>gi|4503743 flightless I homolog [Homo sapiens]
Length = 1269
Score = 154 bits (390), Expect = 2e-37
Identities = 116/374 (31%), Positives = 174/374 (46%), Gaps = 34/374 (9%)
Query: 139 PAEVGCLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLY 198
P V + +L L L+ L LP+ L L+KL L + HN L + + L SL +
Sbjct: 26 PENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAIV 85
Query: 199 LRFNRITT--VEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKE 256
R N + V DI L LS+L + N++ + P E+ N++ L+++HN ++ +P +
Sbjct: 86 ARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQ 145
Query: 257 IG-NCTQITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRL-SAIPRSLAKCSALEELNL 314
+ N T + LDL N L LP + L L L L N L A R L +AL+ L+L
Sbjct: 146 LFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTLHL 205
Query: 315 ENNNI--STLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPF 372
+ S LP SL S + +++ N + ++P
Sbjct: 206 RSTQRTQSNLPTSL-------------------------EGLSNLADVDLSCNDLTRVPE 240
Query: 373 GIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLIL 432
+++ L +LN+ NQ+T L L W + LNL+ NQLT +P + L L+ L L
Sbjct: 241 CLYTLPS-LRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYL 299
Query: 433 SNNLLK--KLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGI 490
++N L LP G+G L L E N LE +P + L+KLVL N L TLP I
Sbjct: 300 NSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAI 359
Query: 491 GHLTNLTHLGLGEN 504
LT + L + EN
Sbjct: 360 HFLTEIEVLDVREN 373
Score = 147 bits (372), Expect = 2e-35
Identities = 111/377 (29%), Positives = 177/377 (46%), Gaps = 34/377 (9%)
Query: 162 PDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLS 221
P+++ + LR L L L +P + L L L + N +TT+ ++ +L L +
Sbjct: 26 PENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAIV 85
Query: 222 IRENKIKQ--LPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDT 279
R N +K +P +I +L +L LD++HNQL P+E+ N + L+L HN + +P+
Sbjct: 86 ARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQ 145
Query: 280 IG-NLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTL 338
+ NL+ L L L NRL ++P + + L+ L L N + L ++ L +L L
Sbjct: 146 LFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTLHL 205
Query: 339 ARNCFQLYPVGGPSQF---STIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLP 395
Q P+ S + +++ N + ++P +++ L +LN+ NQ+T L
Sbjct: 206 RST--QRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPS-LRRLNLSSNQITELS 262
Query: 396 LDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLK--KLPHGLGNLRKLREL 453
L W + LNL+ NQLT +P + L L+ L L++N L LP G+G L L E
Sbjct: 263 LCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEF 322
Query: 454 DLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEI 513
N LE +P + L+KLVL N L TLP E I
Sbjct: 323 MAANNNLELVPESLCRCPKLRKLVLNKNHLVTLP-----------------------EAI 359
Query: 514 GTLENLEELYLNDNPNL 530
L +E L + +NPNL
Sbjct: 360 HFLTEIEVLDVRENPNL 376
Score = 141 bits (355), Expect = 2e-33
Identities = 109/380 (28%), Positives = 188/380 (49%), Gaps = 34/380 (8%)
Query: 116 PSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDSLDNLKKLRMLD 175
P ++K +T L L L L LP E+ L L L++S N+LT+L L +L LR +
Sbjct: 26 PENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAIV 85
Query: 176 LRHNKLRE--IPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLPAE 233
R N L+ +P +++LD L+ L L N++T ++++N + +L++ N I +P +
Sbjct: 86 ARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQ 145
Query: 234 IG-ELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLP-DTIGNLSSLSRLGL 291
+ L +L+ LD++ N+LE LP ++ + L L N LL + +++L L L
Sbjct: 146 LFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTLHL 205
Query: 292 RYNR--LSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVG 349
R + S +P SL S L +++L N+++ +PE L +
Sbjct: 206 RSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYT--------------------- 244
Query: 350 GPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNL 409
++ LN+ N+I ++ I V LN+ NQLTSLP + + +L L
Sbjct: 245 ----LPSLRRLNLSSNQITELSLCIDQWVHV-ETLNLSRNQLTSLPSAICKLSKLKKLYL 299
Query: 410 ATNQL--TKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEI 467
+N+L +P + L +LE + +NN L+ +P L KLR+L L +N L +LP I
Sbjct: 300 NSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAI 359
Query: 468 AYLKDLQKLVLTNNQLTTLP 487
+L +++ L + N +P
Sbjct: 360 HFLTEIEVLDVRENPNLVMP 379
Score = 104 bits (259), Expect = 3e-22
Identities = 92/331 (27%), Positives = 148/331 (44%), Gaps = 37/331 (11%)
Query: 263 ITNLDLQHNELLD--LPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNIS 320
+ +DL N+ P+ + ++SL L L L +P LA LE L++ +NN++
Sbjct: 10 VRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLT 69
Query: 321 TLPESLLSSLVKLNSLTLARNCFQLYPVGGPS---QFSTIYSLNMEHNRINKIPFGIFSR 377
TL LSSL L ++ N L G P + + L++ HN++ + P +
Sbjct: 70 TL-HGELSSLPSLRAIVARAN--SLKNSGVPDDIFKLDDLSVLDLSHNQLTECPREL-EN 125
Query: 378 AKVLSKLNMKDNQLTSLPLD-FGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNL 436
AK + LN+ N + ++P F T ++ L+L+ N+L +P + LV L+ L+L+ N
Sbjct: 126 AKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNP 185
Query: 437 L--------------------------KKLPHGLGNLRKLRELDLEENKLESLPNEIAYL 470
L LP L L L ++DL N L +P + L
Sbjct: 186 LLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTL 245
Query: 471 KDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNP-N 529
L++L L++NQ+T L I ++ L L N LT LP I L L++LYLN N +
Sbjct: 246 PSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLD 305
Query: 530 LHSLPFELALCSKLSIMSIENCPLSHLPPQI 560
LP + + L N L +P +
Sbjct: 306 FDGLPSGIGKLTNLEEFMAANNNLELVPESL 336
Score = 99.8 bits (247), Expect = 6e-21
Identities = 80/256 (31%), Positives = 120/256 (46%), Gaps = 30/256 (11%)
Query: 115 LPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDSL-DNLKKLRM 173
+P I +L L+ L L N+L P E+ N++ L LS NS+ ++P+ L NL L
Sbjct: 96 VPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLY 155
Query: 174 LDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVE-KDIKNLSKLSMLSIRENKIKQ--L 230
LDL N+L +P + RL L TL L N + + + + ++ L L +R + Q L
Sbjct: 156 LDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNL 215
Query: 231 PAEIGELCNLITLDVAHNQLEHLPK-------------------EIGNC----TQITNLD 267
P + L NL +D++ N L +P+ E+ C + L+
Sbjct: 216 PTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLN 275
Query: 268 LQHNELLDLPDTIGNLSSLSRLGLRYNRL--SAIPRSLAKCSALEELNLENNNISTLPES 325
L N+L LP I LS L +L L N+L +P + K + LEE NNN+ +PES
Sbjct: 276 LSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPES 335
Query: 326 LLSSLVKLNSLTLARN 341
L KL L L +N
Sbjct: 336 -LCRCPKLRKLVLNKN 350
Score = 82.0 bits (201), Expect = 1e-15
Identities = 58/210 (27%), Positives = 99/210 (47%), Gaps = 21/210 (10%)
Query: 91 IKELNKCREENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMT 150
+++L ++ L ++R+ LP+S++ L+ L ++ L N L +P + L +L
Sbjct: 191 LRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRR 250
Query: 151 LALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKD 210
L LS N +T L +D + L+L N+L +PS + +L L LYL N++
Sbjct: 251 LNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKL------ 304
Query: 211 IKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQH 270
LP+ IG+L NL A+N LE +P+ + C ++ L L
Sbjct: 305 ---------------DFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNK 349
Query: 271 NELLDLPDTIGNLSSLSRLGLRYNRLSAIP 300
N L+ LP+ I L+ + L +R N +P
Sbjct: 350 NHLVTLPEAIHFLTEIEVLDVRENPNLVMP 379
>gi|65301141 PH domain and leucine rich repeat protein
phosphatase-like [Homo sapiens]
Length = 1323
Score = 153 bits (386), Expect = 5e-37
Identities = 143/480 (29%), Positives = 224/480 (46%), Gaps = 42/480 (8%)
Query: 105 LDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDS 164
L+LS + + P + E++ LTEL L N LP+++G L+NL TL L N LT+LP+
Sbjct: 304 LNLSHNKLGLFPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEE 363
Query: 165 LDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYL--------------RFNRI------ 204
L NL++L L + N +IP V +L L + + R N I
Sbjct: 364 LGNLQQLSSLGISFNNFSQIPEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLR 423
Query: 205 -----TTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGN 259
T V ++++ ++ + +R+N++ L ++ LC+L L NQL L +
Sbjct: 424 MNHLKTMVIENLEGNKHITHVDLRDNRLTDL--DLSSLCSLEQLHCGRNQLRELTL---S 478
Query: 260 CTQITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNI 319
+ L N L + + S L+ L L N L +P + +E L++ N +
Sbjct: 479 GFSLRTLYASSNRLTAV-NVYPVPSLLTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLL 537
Query: 320 STLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAK 379
+ +P +LSSL L L L N Q P + + L+++HN + ++P +FS+A
Sbjct: 538 TEVPVRILSSL-SLRKLMLGHNHVQNLPT--LVEHIPLEVLDLQHNALTRLPDTLFSKAL 594
Query: 380 VLSKLNMKDNQLTSLP--LDFGTWTSMVELNLATNQLTK---IPEDVSGLVSLEVLILSN 434
L LN N L SLP SM++L TN L IP V G + L +L L+N
Sbjct: 595 NLRYLNASANSLESLPSACTGEESLSMLQLLYLTNNLLTDQCIPVLV-GHLHLRILHLAN 653
Query: 435 NLLKKLPHG-LGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHL 493
N L+ P L L +L EL+L NKL+++P IA K L LV +N ++ P I L
Sbjct: 654 NQLQTFPASKLNKLEQLEELNLSGNKLKTIPTTIANCKRLHTLVAHSNNISIFPE-ILQL 712
Query: 494 TNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPL 553
+ + L N LT + L++L L N NL L + S ++ + I+ PL
Sbjct: 713 PQIQFVDLSCNDLTEILIPEALPATLQDLDLTGNTNLVLEHKTLDIFSHITTLKIDQKPL 772
Score = 127 bits (319), Expect = 3e-29
Identities = 141/480 (29%), Positives = 204/480 (42%), Gaps = 93/480 (19%)
Query: 148 LMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTV 207
+ T+ LS SL +P+ L + + L+LRHN ++ + R L TLY
Sbjct: 251 ISTVDLSCYSLEEVPEHLFYSQDITYLNLRHNFMQ-----LERPGGLDTLY--------- 296
Query: 208 EKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLD 267
S+L L++ NK+ P + E+ L L+++ N LP +IGN + L
Sbjct: 297 -----KFSQLKGLNLSHNKLGLFPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLC 351
Query: 268 LQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEEL--------------- 312
L N L LP+ +GNL LS LG+ +N S IP K + L+ +
Sbjct: 352 LDGNFLTTLPEELGNLQQLSSLGISFNNFSQIPEVYEKLTMLDRVVMAGNCLEVLNLGVL 411
Query: 313 ----------------------NLENNNIST--------LPESLLSSLVKLNSLTLARNC 342
NLE N T L + LSSL L L RN
Sbjct: 412 NRMNHIKHVDLRMNHLKTMVIENLEGNKHITHVDLRDNRLTDLDLSSLCSLEQLHCGRNQ 471
Query: 343 FQLYPVGGPSQFSTIYSLNMEHNRINKIP------FGIFSR------------AKVLSKL 384
+ + G S T+Y+ + +N P F SR AK + L
Sbjct: 472 LRELTLSGFS-LRTLYASSNRLTAVNVYPVPSLLTFLDLSRNLLECVPDWACEAKKIEVL 530
Query: 385 NMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGL 444
++ N LT +P+ + S+ +L L N + +P V + LEVL L +N L +LP L
Sbjct: 531 DVSYNLLTEVPVRILSSLSLRKLMLGHNHVQNLPTLVEH-IPLEVLDLQHNALTRLPDTL 589
Query: 445 -GNLRKLRELDLEENKLESLPNEIA---YLKDLQKLVLTNNQLT--TLPRGIGHLTNLTH 498
LR L+ N LESLP+ L LQ L LTNN LT +P +GHL +L
Sbjct: 590 FSKALNLRYLNASANSLESLPSACTGEESLSMLQLLYLTNNLLTDQCIPVLVGHL-HLRI 648
Query: 499 LGLGENLLTHLP-EEIGTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLSHLP 557
L L N L P ++ LE LEEL L+ N L ++P +A C +L + + +S P
Sbjct: 649 LHLANNQLQTFPASKLNKLEQLEELNLSGN-KLKTIPTTIANCKRLHTLVAHSNNISIFP 707
>gi|37221175 PH domain and leucine rich repeat protein phosphatase
[Homo sapiens]
Length = 1205
Score = 145 bits (366), Expect = 1e-34
Identities = 134/476 (28%), Positives = 235/476 (49%), Gaps = 35/476 (7%)
Query: 83 KKSSNAEVIKELNKCREENSMR-LDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAE 141
+++ + + LN+ + ++ L+LS + P ++ + L EL + N L+S+PA
Sbjct: 161 RQNPSLPAARGLNELQRFTKLKSLNLSNNHLGDFPLAVCSIPTLAELNVSCNALRSVPAA 220
Query: 142 VGCLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRF 201
VG + NL T L N L SLP L+N+K+L L L N+ +IP V+ +L ++ L +
Sbjct: 221 VGVMHNLQTFLLDGNFLQSLPAELENMKQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMSG 280
Query: 202 NRITTVE-KDIKNLSKLSMLSIRENKIKQLPA-EIGELCNLITLDVAHNQLEHLPK---- 255
N + T+ + ++ + + + +R N I++L A E+ L ++ LD+ N+L L
Sbjct: 281 NCVETLRLQALRKMPHIKHVDLRLNVIRKLIADEVDFLQHVTQLDLRDNKLGDLDAMIFN 340
Query: 256 --EIGNC--TQITNLDL----------QHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPR 301
E+ +C Q+ LD+ NEL+ L D + LS + + NRL +P
Sbjct: 341 NIEVLHCERNQLVTLDICGYFLKALYASSNELVQL-DVYPVPNYLSYMDVSRNRLENVPE 399
Query: 302 SLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLN 361
+ + LE L++ +N I LP L + L L N QL + + +++ L+
Sbjct: 400 WVCESRKLEVLDIGHNQICELPARLFCN-SSLRKLLAGHN--QLARLPERLERTSVEVLD 456
Query: 362 MEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLP---LDFGTWTSMVELNLATNQLT-KI 417
++HN++ ++P + +A L LN N+L SLP L T + + EL L N LT K
Sbjct: 457 VQHNQLLELPPNLLMKADSLRFLNASANKLESLPPATLSEETNSILQELYLTNNSLTDKC 516
Query: 418 PEDVSGLVSLEVLILSNNLLKKLPHG-LGNLRKLRELDLEENKLESLPNEIAYLKDLQKL 476
++G L++L ++ N L+ P + L +L E+DL NKL+++P I + + +
Sbjct: 517 VPLLTGHPHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKAIPTTIMNCRRMHTV 576
Query: 477 VLTNNQLTTLPRGIGHLTNLTHLGLGENLLTH--LPEEIGTLENLEELYLNDNPNL 530
+ +N + P + L + + L N L+ LPE + L+EL L NP L
Sbjct: 577 IAHSNCIEVFPE-VMQLPEIKCVDLSCNELSEVTLPENLP--PKLQELDLTGNPRL 629
Score = 131 bits (329), Expect = 2e-30
Identities = 141/487 (28%), Positives = 243/487 (49%), Gaps = 46/487 (9%)
Query: 91 IKELNKCREENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQ---SLPA-----EV 142
+++++K + +DLS S+ LP+++ LT L L N L+ SLPA E+
Sbjct: 116 LRQVSKVASQRISSVDLSCCSLEHLPANLFYSQDLTHLNLKQNFLRQNPSLPAARGLNEL 175
Query: 143 GCLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFN 202
L +L LS N L P ++ ++ L L++ N LR +P+ V + +L T L N
Sbjct: 176 QRFTKLKSLNLSNNHLGDFPLAVCSIPTLAELNVSCNALRSVPAAVGVMHNLQTFLLDGN 235
Query: 203 RITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLP-KEIGNCT 261
+ ++ +++N+ +LS L + N+ +P + +L + L ++ N +E L + +
Sbjct: 236 FLQSLPAELENMKQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMSGNCVETLRLQALRKMP 295
Query: 262 QITNLDLQHNELLDL-PDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNIS 320
I ++DL+ N + L D + L +++L LR N+L + + + +E L+ E N +
Sbjct: 296 HIKHVDLRLNVIRKLIADEVDFLQHVTQLDLRDNKLGDLDAMI--FNNIEVLHCERNQLV 353
Query: 321 TLP------ESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGI 374
TL ++L +S +L L +YPV P+ S +++ NR+ +P +
Sbjct: 354 TLDICGYFLKALYASSNELVQL-------DVYPV--PNYLS---YMDVSRNRLENVPEWV 401
Query: 375 FSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSN 434
K L L++ NQ+ LP +S+ +L NQL ++PE + S+EVL + +
Sbjct: 402 CESRK-LEVLDIGHNQICELPARLFCNSSLRKLLAGHNQLARLPERLE-RTSVEVLDVQH 459
Query: 435 NLLKKLPHG-LGNLRKLRELDLEENKLESLPNEIAYLKD-----LQKLVLTNNQLT--TL 486
N L +LP L LR L+ NKLESLP A L + LQ+L LTNN LT +
Sbjct: 460 NQLLELPPNLLMKADSLRFLNASANKLESLPP--ATLSEETNSILQELYLTNNSLTDKCV 517
Query: 487 PRGIGHLTNLTHLGLGENLLTHLP-EEIGTLENLEELYLNDNPNLHSLPFELALCSKL-S 544
P GH +L L + N L P ++ LE LEE+ L+ N L ++P + C ++ +
Sbjct: 518 PLLTGH-PHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGN-KLKAIPTTIMNCRRMHT 575
Query: 545 IMSIENC 551
+++ NC
Sbjct: 576 VIAHSNC 582
>gi|110825984 malignant fibrous histiocytoma amplified sequence 1
[Homo sapiens]
Length = 1052
Score = 143 bits (361), Expect = 4e-34
Identities = 107/364 (29%), Positives = 175/364 (48%), Gaps = 30/364 (8%)
Query: 213 NLSKLSMLSIRENKIKQLPAEIGE-LCNLITLDVAHNQLEHLPKEIGNCTQ-ITNLDLQH 270
NL + L++ N ++++P +G L +L L + N+ LP + +T LD+ H
Sbjct: 61 NLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSH 120
Query: 271 NELLDL-PDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSS 329
N L L + + L L +L L +N+L A+P L + LEEL++ N ++ LP+SL
Sbjct: 121 NRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSL--- 177
Query: 330 LVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDN 389
S S + +L+++HN++ P + L +L++ N
Sbjct: 178 ----------------------SCLSRLRTLDVDHNQLTAFPRQLLQLV-ALEELDVSSN 214
Query: 390 QLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRK 449
+L LP D ++ L L+ +L +P L SLE L+L NN L+ LP L++
Sbjct: 215 RLRGLPEDISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQR 274
Query: 450 LRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHL 509
L+ L+L N E P + L L++L L+ NQLT++P I L L L L N + +L
Sbjct: 275 LKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYL 334
Query: 510 PEEIGTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLSHLPPQIVAGGPSFII 569
P+ I L LEEL L N + LP S++ + I++ PL P ++ G +I
Sbjct: 335 PDSIVELTGLEELVLQGN-QIAVLPDHFGQLSRVGLWKIKDNPLIQPPYEVCMKGIPYIA 393
Query: 570 QFLK 573
+ K
Sbjct: 394 AYQK 397
Score = 129 bits (323), Expect = 1e-29
Identities = 90/281 (32%), Positives = 131/281 (46%), Gaps = 24/281 (8%)
Query: 304 AKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNME 363
A +E LNL NN + +PE L S+L L L L RN F P + L++
Sbjct: 60 ANLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVS 119
Query: 364 HNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSG 423
HNR+ + + S + L KLN+ NQL +LP G + EL+++ N+L +P+ +S
Sbjct: 120 HNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSC 179
Query: 424 LVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLK------------ 471
L L L + +N L P L L L ELD+ N+L LP +I+ L+
Sbjct: 180 LSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAEL 239
Query: 472 -----------DLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLE 520
L+ L+L NN L LP L L L L NL P + L LE
Sbjct: 240 GTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLE 299
Query: 521 ELYLNDNPNLHSLPFELALCSKLSIMSIENCPLSHLPPQIV 561
ELYL+ N L S+P ++ +L + ++N + +LP IV
Sbjct: 300 ELYLSRN-QLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIV 339
Score = 118 bits (295), Expect = 2e-26
Identities = 78/243 (32%), Positives = 119/243 (48%), Gaps = 5/243 (2%)
Query: 82 RKKSSNAEVIKELNKCREENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAE 141
R + AEV+ L + R +L+LS + LP+ + L L EL + N+L LP
Sbjct: 122 RLTALGAEVVSALRELR-----KLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDS 176
Query: 142 VGCLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRF 201
+ CL L TL + N LT+ P L L L LD+ N+LR +P + L +L L+L
Sbjct: 177 LSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSG 236
Query: 202 NRITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCT 261
+ T+ L+ L L + N ++ LPA+ L L L+++ N E P +
Sbjct: 237 AELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLA 296
Query: 262 QITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNIST 321
+ L L N+L +P I L L L L NR+ +P S+ + + LEEL L+ N I+
Sbjct: 297 GLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAV 356
Query: 322 LPE 324
LP+
Sbjct: 357 LPD 359
Score = 116 bits (290), Expect = 6e-26
Identities = 81/244 (33%), Positives = 130/244 (53%), Gaps = 2/244 (0%)
Query: 105 LDLSKRSIHILPSSI-KELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPD 163
LD+S + L + + L +L +L L N+L +LPA++G L +L L +S N L LPD
Sbjct: 116 LDVSHNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPD 175
Query: 164 SLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIR 223
SL L +LR LD+ HN+L P + +L +L L + NR+ + +DI L L +L +
Sbjct: 176 SLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLS 235
Query: 224 ENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNL 283
++ LPA EL +L +L + +N L+ LP + ++ L+L N + P + L
Sbjct: 236 GAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPL 295
Query: 284 SSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCF 343
+ L L L N+L+++P ++ L L L+NN I LP+S++ L L L L N
Sbjct: 296 AGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIV-ELTGLEELVLQGNQI 354
Query: 344 QLYP 347
+ P
Sbjct: 355 AVLP 358
Score = 79.7 bits (195), Expect = 7e-15
Identities = 54/151 (35%), Positives = 74/151 (49%)
Query: 107 LSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDSLD 166
LS + LP+ EL L L L +N LQ+LPA+ CL L L LS N P +L
Sbjct: 234 LSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALL 293
Query: 167 NLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENK 226
L L L L N+L +PS++ L L TL+L NRI + I L+ L L ++ N+
Sbjct: 294 PLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQ 353
Query: 227 IKQLPAEIGELCNLITLDVAHNQLEHLPKEI 257
I LP G+L + + N L P E+
Sbjct: 354 IAVLPDHFGQLSRVGLWKIKDNPLIQPPYEV 384
Score = 68.2 bits (165), Expect = 2e-11
Identities = 43/138 (31%), Positives = 67/138 (48%)
Query: 97 CREENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSEN 156
C + L L + LP+ L +L L L SN + PA + L L L LS N
Sbjct: 247 CELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRN 306
Query: 157 SLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSK 216
LTS+P + L +L L L +N++R +P + L L L L+ N+I + LS+
Sbjct: 307 QLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDHFGQLSR 366
Query: 217 LSMLSIRENKIKQLPAEI 234
+ + I++N + Q P E+
Sbjct: 367 VGLWKIKDNPLIQPPYEV 384
>gi|62241040 leucine rich repeat containing 8 family, member A [Homo
sapiens]
Length = 810
Score = 130 bits (326), Expect = 4e-30
Identities = 128/425 (30%), Positives = 193/425 (45%), Gaps = 40/425 (9%)
Query: 153 LSENSLTSLPDSLDN---LKKLRM---------LDLRHNKLREIPSVVYRLDSLTTLYLR 200
+SEN L L +L+N L KLR L+L L IP V+ L L L L
Sbjct: 397 VSENKLRQL--NLNNEWTLDKLRQRLTKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLE 454
Query: 201 FNRITTVEKDIKNLSKLSMLSIRENKIK-QLPAEIGELCNLITLDVAHNQLEHLPKEIGN 259
T+ I L+ L L + K + PA NL L + ++ +P I +
Sbjct: 455 LIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYS 514
Query: 260 CTQITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNI 319
+ L L GNLS+ + NR I L + L+ L L++N +
Sbjct: 515 LKTLEELHLT-----------GNLSAEN------NRYIVID-GLRELKRLKVLRLKSN-L 555
Query: 320 STLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAK 379
S LP+ + V L L++ +L + + + + L + + +IP IFS
Sbjct: 556 SKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHN 615
Query: 380 VLSKLNMKDNQLTSLP--LDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLL 437
L ++++KDN L ++ + F + L L N + IP + L +LE L L+ N +
Sbjct: 616 -LQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKI 674
Query: 438 KKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLT 497
+K+P L RKLR LDL N L LP +I L++LQ L +T N++ TLP + L
Sbjct: 675 EKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLR 734
Query: 498 HLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSLPFELALCS--KLSIMSIENCPLSH 555
L LG N+L LP +G L NL ++ L N L LP EL C K S + +E +
Sbjct: 735 ALHLGNNVLQSLPSRVGELTNLTQIELRGN-RLECLPVELGECPLLKRSGLVVEEDLFNT 793
Query: 556 LPPQI 560
LPP++
Sbjct: 794 LPPEV 798
Score = 117 bits (294), Expect = 2e-26
Identities = 74/221 (33%), Positives = 120/221 (54%), Gaps = 4/221 (1%)
Query: 114 ILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPD--SLDNLKKL 171
I+ +S+K++ LTEL L L+ +P + L NL + L +N+L ++ + S +L +L
Sbjct: 582 IVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRL 641
Query: 172 RMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLP 231
L L +N + IP + L +L LYL N+I + + KL L + N + LP
Sbjct: 642 TCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLP 701
Query: 232 AEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRLGL 291
A+IG L NL L + N++E LP E+ C ++ L L +N L LP +G L++L+++ L
Sbjct: 702 ADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIEL 761
Query: 292 RYNRLSAIPRSLAKCSALEE--LNLENNNISTLPESLLSSL 330
R NRL +P L +C L+ L +E + +TLP + L
Sbjct: 762 RGNRLECLPVELGECPLLKRSGLVVEEDLFNTLPPEVKERL 802
Score = 99.8 bits (247), Expect = 6e-21
Identities = 56/162 (34%), Positives = 89/162 (54%), Gaps = 2/162 (1%)
Query: 101 NSMRLDLSKRSIHILPS--SIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSL 158
N +DL ++ + S + L +LT L L+ N + +P ++G L NL L L+ N +
Sbjct: 615 NLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKI 674
Query: 159 TSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLS 218
+P L +KLR LDL HN L +P+ + L +L L + NRI T+ ++ KL
Sbjct: 675 EKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLR 734
Query: 219 MLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNC 260
L + N ++ LP+ +GEL NL +++ N+LE LP E+G C
Sbjct: 735 ALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGEC 776
Score = 95.1 bits (235), Expect = 2e-19
Identities = 89/337 (26%), Positives = 141/337 (41%), Gaps = 82/337 (24%)
Query: 115 LPSSIKELTQLTELYLYS------------------------NKLQSLPAEVGCLVNLMT 150
+P SI +LT L EL+LY ++ +P + L L
Sbjct: 461 IPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEE 520
Query: 151 LAL-----SENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVV----------------- 188
L L +EN+ + D L LK+L++L L+ N L ++P VV
Sbjct: 521 LHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGT 579
Query: 189 -------------------------------YRLDSLTTLYLRFNRITTVEKDI--KNLS 215
+ L +L + L+ N + T+E+ I ++L
Sbjct: 580 KLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLH 639
Query: 216 KLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLD 275
+L+ L + N I +P +IG L NL L + N++E +P ++ C ++ LDL HN L
Sbjct: 640 RLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTF 699
Query: 276 LPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNS 335
LP IG L +L L + NR+ +P L +C L L+L NN + +LP S + L L
Sbjct: 700 LPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLP-SRVGELTNLTQ 758
Query: 336 LTLARNCFQLYPVG-GPSQFSTIYSLNMEHNRINKIP 371
+ L N + PV G L +E + N +P
Sbjct: 759 IELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLP 795
Score = 43.5 bits (101), Expect = 5e-04
Identities = 26/73 (35%), Positives = 37/73 (50%)
Query: 100 ENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLT 159
+N L ++ I LP + + +L L+L +N LQSLP+ VG L NL + L N L
Sbjct: 708 QNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLE 767
Query: 160 SLPDSLDNLKKLR 172
LP L L+
Sbjct: 768 CLPVELGECPLLK 780
>gi|187829877 leucine rich repeat containing 8 family, member A
[Homo sapiens]
Length = 810
Score = 130 bits (326), Expect = 4e-30
Identities = 128/425 (30%), Positives = 193/425 (45%), Gaps = 40/425 (9%)
Query: 153 LSENSLTSLPDSLDN---LKKLRM---------LDLRHNKLREIPSVVYRLDSLTTLYLR 200
+SEN L L +L+N L KLR L+L L IP V+ L L L L
Sbjct: 397 VSENKLRQL--NLNNEWTLDKLRQRLTKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLE 454
Query: 201 FNRITTVEKDIKNLSKLSMLSIRENKIK-QLPAEIGELCNLITLDVAHNQLEHLPKEIGN 259
T+ I L+ L L + K + PA NL L + ++ +P I +
Sbjct: 455 LIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYS 514
Query: 260 CTQITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNI 319
+ L L GNLS+ + NR I L + L+ L L++N +
Sbjct: 515 LKTLEELHLT-----------GNLSAEN------NRYIVID-GLRELKRLKVLRLKSN-L 555
Query: 320 STLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAK 379
S LP+ + V L L++ +L + + + + L + + +IP IFS
Sbjct: 556 SKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHN 615
Query: 380 VLSKLNMKDNQLTSLP--LDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLL 437
L ++++KDN L ++ + F + L L N + IP + L +LE L L+ N +
Sbjct: 616 -LQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKI 674
Query: 438 KKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLT 497
+K+P L RKLR LDL N L LP +I L++LQ L +T N++ TLP + L
Sbjct: 675 EKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLR 734
Query: 498 HLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSLPFELALCS--KLSIMSIENCPLSH 555
L LG N+L LP +G L NL ++ L N L LP EL C K S + +E +
Sbjct: 735 ALHLGNNVLQSLPSRVGELTNLTQIELRGN-RLECLPVELGECPLLKRSGLVVEEDLFNT 793
Query: 556 LPPQI 560
LPP++
Sbjct: 794 LPPEV 798
Score = 117 bits (294), Expect = 2e-26
Identities = 74/221 (33%), Positives = 120/221 (54%), Gaps = 4/221 (1%)
Query: 114 ILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPD--SLDNLKKL 171
I+ +S+K++ LTEL L L+ +P + L NL + L +N+L ++ + S +L +L
Sbjct: 582 IVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRL 641
Query: 172 RMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLP 231
L L +N + IP + L +L LYL N+I + + KL L + N + LP
Sbjct: 642 TCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLP 701
Query: 232 AEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRLGL 291
A+IG L NL L + N++E LP E+ C ++ L L +N L LP +G L++L+++ L
Sbjct: 702 ADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIEL 761
Query: 292 RYNRLSAIPRSLAKCSALEE--LNLENNNISTLPESLLSSL 330
R NRL +P L +C L+ L +E + +TLP + L
Sbjct: 762 RGNRLECLPVELGECPLLKRSGLVVEEDLFNTLPPEVKERL 802
Score = 99.8 bits (247), Expect = 6e-21
Identities = 56/162 (34%), Positives = 89/162 (54%), Gaps = 2/162 (1%)
Query: 101 NSMRLDLSKRSIHILPS--SIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSL 158
N +DL ++ + S + L +LT L L+ N + +P ++G L NL L L+ N +
Sbjct: 615 NLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKI 674
Query: 159 TSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLS 218
+P L +KLR LDL HN L +P+ + L +L L + NRI T+ ++ KL
Sbjct: 675 EKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLR 734
Query: 219 MLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNC 260
L + N ++ LP+ +GEL NL +++ N+LE LP E+G C
Sbjct: 735 ALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGEC 776
Score = 95.1 bits (235), Expect = 2e-19
Identities = 89/337 (26%), Positives = 141/337 (41%), Gaps = 82/337 (24%)
Query: 115 LPSSIKELTQLTELYLYS------------------------NKLQSLPAEVGCLVNLMT 150
+P SI +LT L EL+LY ++ +P + L L
Sbjct: 461 IPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEE 520
Query: 151 LAL-----SENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVV----------------- 188
L L +EN+ + D L LK+L++L L+ N L ++P VV
Sbjct: 521 LHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGT 579
Query: 189 -------------------------------YRLDSLTTLYLRFNRITTVEKDI--KNLS 215
+ L +L + L+ N + T+E+ I ++L
Sbjct: 580 KLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLH 639
Query: 216 KLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLD 275
+L+ L + N I +P +IG L NL L + N++E +P ++ C ++ LDL HN L
Sbjct: 640 RLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTF 699
Query: 276 LPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNS 335
LP IG L +L L + NR+ +P L +C L L+L NN + +LP S + L L
Sbjct: 700 LPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLP-SRVGELTNLTQ 758
Query: 336 LTLARNCFQLYPVG-GPSQFSTIYSLNMEHNRINKIP 371
+ L N + PV G L +E + N +P
Sbjct: 759 IELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLP 795
Score = 43.5 bits (101), Expect = 5e-04
Identities = 26/73 (35%), Positives = 37/73 (50%)
Query: 100 ENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLT 159
+N L ++ I LP + + +L L+L +N LQSLP+ VG L NL + L N L
Sbjct: 708 QNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLE 767
Query: 160 SLPDSLDNLKKLR 172
LP L L+
Sbjct: 768 CLPVELGECPLLK 780
>gi|187829871 leucine rich repeat containing 8 family, member A
[Homo sapiens]
Length = 810
Score = 130 bits (326), Expect = 4e-30
Identities = 128/425 (30%), Positives = 193/425 (45%), Gaps = 40/425 (9%)
Query: 153 LSENSLTSLPDSLDN---LKKLRM---------LDLRHNKLREIPSVVYRLDSLTTLYLR 200
+SEN L L +L+N L KLR L+L L IP V+ L L L L
Sbjct: 397 VSENKLRQL--NLNNEWTLDKLRQRLTKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLE 454
Query: 201 FNRITTVEKDIKNLSKLSMLSIRENKIK-QLPAEIGELCNLITLDVAHNQLEHLPKEIGN 259
T+ I L+ L L + K + PA NL L + ++ +P I +
Sbjct: 455 LIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYS 514
Query: 260 CTQITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNI 319
+ L L GNLS+ + NR I L + L+ L L++N +
Sbjct: 515 LKTLEELHLT-----------GNLSAEN------NRYIVID-GLRELKRLKVLRLKSN-L 555
Query: 320 STLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAK 379
S LP+ + V L L++ +L + + + + L + + +IP IFS
Sbjct: 556 SKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHN 615
Query: 380 VLSKLNMKDNQLTSLP--LDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLL 437
L ++++KDN L ++ + F + L L N + IP + L +LE L L+ N +
Sbjct: 616 -LQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKI 674
Query: 438 KKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLT 497
+K+P L RKLR LDL N L LP +I L++LQ L +T N++ TLP + L
Sbjct: 675 EKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLR 734
Query: 498 HLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSLPFELALCS--KLSIMSIENCPLSH 555
L LG N+L LP +G L NL ++ L N L LP EL C K S + +E +
Sbjct: 735 ALHLGNNVLQSLPSRVGELTNLTQIELRGN-RLECLPVELGECPLLKRSGLVVEEDLFNT 793
Query: 556 LPPQI 560
LPP++
Sbjct: 794 LPPEV 798
Score = 117 bits (294), Expect = 2e-26
Identities = 74/221 (33%), Positives = 120/221 (54%), Gaps = 4/221 (1%)
Query: 114 ILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPD--SLDNLKKL 171
I+ +S+K++ LTEL L L+ +P + L NL + L +N+L ++ + S +L +L
Sbjct: 582 IVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRL 641
Query: 172 RMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLP 231
L L +N + IP + L +L LYL N+I + + KL L + N + LP
Sbjct: 642 TCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLP 701
Query: 232 AEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRLGL 291
A+IG L NL L + N++E LP E+ C ++ L L +N L LP +G L++L+++ L
Sbjct: 702 ADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIEL 761
Query: 292 RYNRLSAIPRSLAKCSALEE--LNLENNNISTLPESLLSSL 330
R NRL +P L +C L+ L +E + +TLP + L
Sbjct: 762 RGNRLECLPVELGECPLLKRSGLVVEEDLFNTLPPEVKERL 802
Score = 99.8 bits (247), Expect = 6e-21
Identities = 56/162 (34%), Positives = 89/162 (54%), Gaps = 2/162 (1%)
Query: 101 NSMRLDLSKRSIHILPS--SIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSL 158
N +DL ++ + S + L +LT L L+ N + +P ++G L NL L L+ N +
Sbjct: 615 NLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKI 674
Query: 159 TSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLS 218
+P L +KLR LDL HN L +P+ + L +L L + NRI T+ ++ KL
Sbjct: 675 EKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLR 734
Query: 219 MLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNC 260
L + N ++ LP+ +GEL NL +++ N+LE LP E+G C
Sbjct: 735 ALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGEC 776
Score = 95.1 bits (235), Expect = 2e-19
Identities = 89/337 (26%), Positives = 141/337 (41%), Gaps = 82/337 (24%)
Query: 115 LPSSIKELTQLTELYLYS------------------------NKLQSLPAEVGCLVNLMT 150
+P SI +LT L EL+LY ++ +P + L L
Sbjct: 461 IPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEE 520
Query: 151 LAL-----SENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVV----------------- 188
L L +EN+ + D L LK+L++L L+ N L ++P VV
Sbjct: 521 LHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGT 579
Query: 189 -------------------------------YRLDSLTTLYLRFNRITTVEKDI--KNLS 215
+ L +L + L+ N + T+E+ I ++L
Sbjct: 580 KLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLH 639
Query: 216 KLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLD 275
+L+ L + N I +P +IG L NL L + N++E +P ++ C ++ LDL HN L
Sbjct: 640 RLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTF 699
Query: 276 LPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNS 335
LP IG L +L L + NR+ +P L +C L L+L NN + +LP S + L L
Sbjct: 700 LPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLP-SRVGELTNLTQ 758
Query: 336 LTLARNCFQLYPVG-GPSQFSTIYSLNMEHNRINKIP 371
+ L N + PV G L +E + N +P
Sbjct: 759 IELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLP 795
Score = 43.5 bits (101), Expect = 5e-04
Identities = 26/73 (35%), Positives = 37/73 (50%)
Query: 100 ENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLT 159
+N L ++ I LP + + +L L+L +N LQSLP+ VG L NL + L N L
Sbjct: 708 QNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLE 767
Query: 160 SLPDSLDNLKKLR 172
LP L L+
Sbjct: 768 CLPVELGECPLLK 780
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 127 bits (318), Expect = 4e-29
Identities = 112/367 (30%), Positives = 175/367 (47%), Gaps = 32/367 (8%)
Query: 148 LMTLALSENSLTSL-PDSLDNLKKLRMLDLRHNKLREIPSVVYR-LDSLTTLYLRFNRIT 205
L+ L + +N L+ + P + NL LR L L +NKL+ +P +++ LDSL +L L N++
Sbjct: 85 LIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLL 144
Query: 206 TVEK-DIKNLSKLSMLSIRENKIKQLP-AEIGELCNLITLDVAHNQLEHL-PKEIGNCTQ 262
++ S L L + N ++ +P L L L++ N L H+ P+ +
Sbjct: 145 QIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGN 204
Query: 263 ITNLDLQHNELLDLP-DTIGNLSSLSRLGLRYNRLSAI-PRSLAKCSALEELNLENNNIS 320
+ L L N L D+P T L +L L L+ N++ + P L+ L L NN+IS
Sbjct: 205 LQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHIS 264
Query: 321 TLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKV 380
LP S+ L +LN LTL N + +G + L + N I+ +P +FS +
Sbjct: 265 QLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQ 324
Query: 381 LSKLNMKDNQLTSL-PLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKK 439
L L + NQ++ + P F T + EL+L TN L +D+ G N+ +
Sbjct: 325 LQVLILSRNQISFISPGAFNGLTELRELSLHTNAL----QDLDG-----------NVFRM 369
Query: 440 LPHGLGNLRKLRELDLEENKLESLPNEI-AYLKDLQKLVLTNNQLTTLPRGI-GHLTNLT 497
L + L+ + L+ N+L LP I A + L + L NNQL LP GI HL L
Sbjct: 370 LAN-------LQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLC 422
Query: 498 HLGLGEN 504
L L +N
Sbjct: 423 ELRLYDN 429
Score = 100 bits (250), Expect = 3e-21
Identities = 99/326 (30%), Positives = 155/326 (47%), Gaps = 11/326 (3%)
Query: 98 REENSMR-LDLSKRSIHILPSSIKE-LTQLTELYLYSNKL-QSLPAEVGCLVNLMTLALS 154
R S+R L L+ + +LP + + L L L L SN+L Q PA NL L L
Sbjct: 104 RNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLH 163
Query: 155 ENSLTSLPD-SLDNLKKLRMLDLRHNKLREI-PSVVYRLDSLTTLYLRFNRITTVEKD-I 211
N L +PD + D+L L L+L N L I P V L +L L L NR+T +
Sbjct: 164 GNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTF 223
Query: 212 KNLSKLSMLSIRENKIKQL-PAEIGELCNLITLDVAHNQLEHLPKEIG-NCTQITNLDLQ 269
L L L++++N+I L P NL L +++N + LP I Q+ L L
Sbjct: 224 DGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLF 283
Query: 270 HNELLDLPDTI-GNLSSLSRLGLRYNRLSAIPRSL-AKCSALEELNLENNNISTLPESLL 327
N L +L I G + +L L L N +S++P ++ + L+ L L N IS +
Sbjct: 284 GNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAF 343
Query: 328 SSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMK 387
+ L +L L+L N Q + + ++++++NR+ ++P IF+ L + ++
Sbjct: 344 NGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQ 403
Query: 388 DNQLTSLPLD-FGTWTSMVELNLATN 412
+NQL +LPL F + EL L N
Sbjct: 404 NNQLENLPLGIFDHLGKLCELRLYDN 429
Score = 95.5 bits (236), Expect = 1e-19
Identities = 92/307 (29%), Positives = 146/307 (47%), Gaps = 11/307 (3%)
Query: 260 CTQITNLDLQHNELLDLPDTIG-NLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNN 318
C++ + ++ ++ +P + N SL L L+ P SAL L +E N
Sbjct: 37 CSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESP--FLNISALIALRIEKNE 94
Query: 319 ISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRA 378
+S + +L L L+LA N Q+ P+G ++ SL + N++ +I FS+
Sbjct: 95 LSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQC 154
Query: 379 KVLSKLNMKDNQLTSLPLD-FGTWTSMVELNLATNQLTKI-PEDVSGLVSLEVLILSNNL 436
L +L + N L +P F + +LNL N LT I P L +L+VL L N
Sbjct: 155 SNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENR 214
Query: 437 LKKLPHG-LGNLRKLRELDLEENKLESL-PNEIAYLKDLQKLVLTNNQLTTLPRGI-GHL 493
L +P G L L+EL L++N++ L P +LQ+L L+NN ++ LP I L
Sbjct: 215 LTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQL 274
Query: 494 TNLTHLGLGENLLTHLPEEI-GTLENLEELYLNDNPNLHSLPFEL-ALCSKLSIMSIENC 551
L L L N L L I G + NL EL+L DN ++ SLP + + +L ++ +
Sbjct: 275 PQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDN-HISSLPDNVFSNLRQLQVLILSRN 333
Query: 552 PLSHLPP 558
+S + P
Sbjct: 334 QISFISP 340
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 127 bits (318), Expect = 4e-29
Identities = 112/367 (30%), Positives = 175/367 (47%), Gaps = 32/367 (8%)
Query: 148 LMTLALSENSLTSL-PDSLDNLKKLRMLDLRHNKLREIPSVVYR-LDSLTTLYLRFNRIT 205
L+ L + +N L+ + P + NL LR L L +NKL+ +P +++ LDSL +L L N++
Sbjct: 79 LIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLL 138
Query: 206 TVEK-DIKNLSKLSMLSIRENKIKQLP-AEIGELCNLITLDVAHNQLEHL-PKEIGNCTQ 262
++ S L L + N ++ +P L L L++ N L H+ P+ +
Sbjct: 139 QIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGN 198
Query: 263 ITNLDLQHNELLDLP-DTIGNLSSLSRLGLRYNRLSAI-PRSLAKCSALEELNLENNNIS 320
+ L L N L D+P T L +L L L+ N++ + P L+ L L NN+IS
Sbjct: 199 LQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHIS 258
Query: 321 TLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKV 380
LP S+ L +LN LTL N + +G + L + N I+ +P +FS +
Sbjct: 259 QLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQ 318
Query: 381 LSKLNMKDNQLTSL-PLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKK 439
L L + NQ++ + P F T + EL+L TN L +D+ G N+ +
Sbjct: 319 LQVLILSRNQISFISPGAFNGLTELRELSLHTNAL----QDLDG-----------NVFRM 363
Query: 440 LPHGLGNLRKLRELDLEENKLESLPNEI-AYLKDLQKLVLTNNQLTTLPRGI-GHLTNLT 497
L + L+ + L+ N+L LP I A + L + L NNQL LP GI HL L
Sbjct: 364 LAN-------LQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLC 416
Query: 498 HLGLGEN 504
L L +N
Sbjct: 417 ELRLYDN 423
Score = 100 bits (250), Expect = 3e-21
Identities = 99/326 (30%), Positives = 155/326 (47%), Gaps = 11/326 (3%)
Query: 98 REENSMR-LDLSKRSIHILPSSIKE-LTQLTELYLYSNKL-QSLPAEVGCLVNLMTLALS 154
R S+R L L+ + +LP + + L L L L SN+L Q PA NL L L
Sbjct: 98 RNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLH 157
Query: 155 ENSLTSLPD-SLDNLKKLRMLDLRHNKLREI-PSVVYRLDSLTTLYLRFNRITTVEKD-I 211
N L +PD + D+L L L+L N L I P V L +L L L NR+T +
Sbjct: 158 GNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTF 217
Query: 212 KNLSKLSMLSIRENKIKQL-PAEIGELCNLITLDVAHNQLEHLPKEIG-NCTQITNLDLQ 269
L L L++++N+I L P NL L +++N + LP I Q+ L L
Sbjct: 218 DGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLF 277
Query: 270 HNELLDLPDTI-GNLSSLSRLGLRYNRLSAIPRSL-AKCSALEELNLENNNISTLPESLL 327
N L +L I G + +L L L N +S++P ++ + L+ L L N IS +
Sbjct: 278 GNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAF 337
Query: 328 SSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMK 387
+ L +L L+L N Q + + ++++++NR+ ++P IF+ L + ++
Sbjct: 338 NGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQ 397
Query: 388 DNQLTSLPLD-FGTWTSMVELNLATN 412
+NQL +LPL F + EL L N
Sbjct: 398 NNQLENLPLGIFDHLGKLCELRLYDN 423
Score = 95.5 bits (236), Expect = 1e-19
Identities = 92/307 (29%), Positives = 146/307 (47%), Gaps = 11/307 (3%)
Query: 260 CTQITNLDLQHNELLDLPDTIG-NLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNN 318
C++ + ++ ++ +P + N SL L L+ P SAL L +E N
Sbjct: 31 CSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESP--FLNISALIALRIEKNE 88
Query: 319 ISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRA 378
+S + +L L L+LA N Q+ P+G ++ SL + N++ +I FS+
Sbjct: 89 LSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQC 148
Query: 379 KVLSKLNMKDNQLTSLPLD-FGTWTSMVELNLATNQLTKI-PEDVSGLVSLEVLILSNNL 436
L +L + N L +P F + +LNL N LT I P L +L+VL L N
Sbjct: 149 SNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENR 208
Query: 437 LKKLPHG-LGNLRKLRELDLEENKLESL-PNEIAYLKDLQKLVLTNNQLTTLPRGI-GHL 493
L +P G L L+EL L++N++ L P +LQ+L L+NN ++ LP I L
Sbjct: 209 LTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQL 268
Query: 494 TNLTHLGLGENLLTHLPEEI-GTLENLEELYLNDNPNLHSLPFEL-ALCSKLSIMSIENC 551
L L L N L L I G + NL EL+L DN ++ SLP + + +L ++ +
Sbjct: 269 PQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDN-HISSLPDNVFSNLRQLQVLILSRN 327
Query: 552 PLSHLPP 558
+S + P
Sbjct: 328 QISFISP 334
>gi|157694513 leucine-rich repeat-containing G protein-coupled
receptor 4 [Homo sapiens]
Length = 951
Score = 125 bits (315), Expect = 8e-29
Identities = 115/419 (27%), Positives = 197/419 (47%), Gaps = 41/419 (9%)
Query: 97 CREENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEV-GCLVNLMTLALSE 155
C + R+D S + + +P + TQ ++ + N + LP + L L L+
Sbjct: 33 CSCDGDRRVDCSGKGLTAVPEGLSAFTQALDISM--NNITQLPEDAFKNFPFLEELQLAG 90
Query: 156 NSLTSL-PDSLDNLKKLRMLDLRHNKLREIPSVVYR-LDSLTTLYLRFNRITTVEKD-IK 212
N L+ + P +L LK+L++L L++N+L+ +PS R L +L +L L N IT+V +D +
Sbjct: 91 NDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFE 150
Query: 213 NLSKLSMLSIRENKIKQLPAE-IGELCNLITLDVAHNQLEHLPK-EIGNCTQITNLDLQH 270
L +L L + +N + ++P + L L L +A N++ +P N + + L L +
Sbjct: 151 GLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHN 210
Query: 271 NELLDLPD-TIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSS 329
N++ L L +L L L YN L P+++ +L+EL +N+IS +P+
Sbjct: 211 NKIRSLSQHCFDGLDNLETLDLNYNNLGEFPQAIKALPSLKELGFHSNSISVIPDGAFDG 270
Query: 330 LVKLNSLTLARNCFQLYPVGG-----------------------PSQFSTIY--SLNMEH 364
L ++ L N L VG P+ T++ SL +
Sbjct: 271 NPLLRTIHLYDN--PLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTG 328
Query: 365 NRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDV-SG 423
+I+ IP + K+L L++ N + LP F ++ E++L NQ+ +I E G
Sbjct: 329 TKISSIPNNLCQEQKMLRTLDLSYNNIRDLP-SFNGCHALEEISLQRNQIYQIKEGTFQG 387
Query: 424 LVSLEVLILSNNLLKKL-PHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNN 481
L+SL +L LS NL+ ++ L + LD+ N+L S P E L L +L L N
Sbjct: 388 LISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTSFPTE--GLNGLNQLKLVGN 444
Score = 93.2 bits (230), Expect = 6e-19
Identities = 87/294 (29%), Positives = 142/294 (48%), Gaps = 12/294 (4%)
Query: 243 LDVAHNQLEHLPKE-IGNCTQITNLDLQHNELLDL-PDTIGNLSSLSRLGLRYNRLSAIP 300
LD++ N + LP++ N + L L N+L + P + L L L L+ N+L +P
Sbjct: 62 LDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVP 121
Query: 301 -RSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYS 359
++ SAL+ L L+ N+I+++PE LV+L L L N PV S T+ +
Sbjct: 122 SEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQA 181
Query: 360 LNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLD-FGTWTSMVELNLATNQLTKIP 418
L + N+I+ IP F+ L L++ +N++ SL F ++ L+L N L + P
Sbjct: 182 LTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFP 241
Query: 419 EDVSGLVSLEVLILSNNLLKKLPHGL--GNLRKLRELDLEENKLESLPNEIAY-LKDLQK 475
+ + L SL+ L +N + +P G GN LR + L +N L + N + L DL
Sbjct: 242 QAIKALPSLKELGFHSNSISVIPDGAFDGN-PLLRTIHLYDNPLSFVGNSAFHNLSDLHS 300
Query: 476 LVLTN-NQLTTLPR--GIGHLTNLTHLGLG-ENLLTHLPEEIGTLENLEELYLN 525
LV+ + + P G HL +LT G ++ +L +E L L+ Y N
Sbjct: 301 LVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNN 354
Score = 84.7 bits (208), Expect = 2e-16
Identities = 80/317 (25%), Positives = 134/317 (42%), Gaps = 34/317 (10%)
Query: 84 KSSNAEVIKELNKCREENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAE-V 142
K+ +E I+ L+ + S+RLD + + S + L QL L+L N L +P +
Sbjct: 118 KTVPSEAIRGLSALQ---SLRLD-ANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPL 173
Query: 143 GCLVNLMTLALSENSLTSLPD-SLDNLKKLRMLDLRHNKLREIPSVVYR-LDSLTTLYLR 200
L L L L+ N ++S+PD + NL L +L L +NK+R + + LD+L TL L
Sbjct: 174 SNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLN 233
Query: 201 FNRITTVEKDIKNLSKLSMLSIRENKIKQLP-------------------------AEIG 235
+N + + IK L L L N I +P +
Sbjct: 234 YNNLGEFPQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFH 293
Query: 236 ELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSR-LGLRYN 294
L +L +L + + + + +L L ++ +P+ + + R L L YN
Sbjct: 294 NLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYN 353
Query: 295 RLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQF 354
+ +P S C ALEE++L+ N I + E L+ L L L+RN +
Sbjct: 354 NIRDLP-SFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATL 412
Query: 355 STIYSLNMEHNRINKIP 371
I +L++ N + P
Sbjct: 413 GPITNLDVSFNELTSFP 429
Score = 83.2 bits (204), Expect = 6e-16
Identities = 70/240 (29%), Positives = 110/240 (45%), Gaps = 11/240 (4%)
Query: 296 LSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFS 355
L+A+P L+ + + L++ NNI+ LPE + L L LA N S
Sbjct: 48 LTAVPEGLSAFT--QALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLK 105
Query: 356 TIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLD-FGTWTSMVELNLATNQL 414
+ L +++N++ +P L L + N +TS+P D F + L L N L
Sbjct: 106 ELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSL 165
Query: 415 TKIP-EDVSGLVSLEVLILSNNLLKKLP-HGLGNLRKLRELDLEENKLESLPNE-IAYLK 471
T++P +S L +L+ L L+ N + +P NL L L L NK+ SL L
Sbjct: 166 TEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLD 225
Query: 472 DLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLEN---LEELYLNDNP 528
+L+ L L N L P+ I L +L LG N ++ +P+ G + L ++L DNP
Sbjct: 226 NLETLDLNYNNLGEFPQAIKALPSLKELGFHSNSISVIPD--GAFDGNPLLRTIHLYDNP 283
>gi|225579152 insulin-like growth factor binding protein, acid
labile subunit isoform 1 precursor [Homo sapiens]
Length = 643
Score = 125 bits (313), Expect = 1e-28
Identities = 132/420 (31%), Positives = 198/420 (47%), Gaps = 45/420 (10%)
Query: 116 PSSIKELTQLTELYLYSNKLQSLPAEVGCLVN---LMTLALSENSLTSLPDSL-DNLKKL 171
P ++ L L L+L N+L+SL +G + L +L LS N L+ L D L + L L
Sbjct: 153 PQALLGLENLCHLHLERNQLRSLA--LGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSL 210
Query: 172 RMLDLRHNKLREIPSVVYR-LDSLTTLYLRFNRITTVEKDI-KNLSKLSMLSIRENKIKQ 229
L+L N L +P +R L SL L L NR+ ++ + L++L L + N ++
Sbjct: 211 WDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRA 270
Query: 230 LPAEIG-ELCNLITLDVAHNQLEHL-PKEIGNCTQITNLDLQHNELLDL-PDTIGNLSSL 286
+ A + +L L L + N + + P + LDL HN + L DT L L
Sbjct: 271 IKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGL 330
Query: 287 SRLGLRYNRLSAI-PRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQL 345
L L +N ++++ PR+ LEEL L +N I L E L +L LTL N Q
Sbjct: 331 RVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQE 390
Query: 346 YPVGG--------------------PSQ----FSTIYSLNMEHNRINKIPFGIFSRAKVL 381
G P Q ++SL++E + + +I F+ L
Sbjct: 391 VKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGL 450
Query: 382 SKLNMKDNQLTSLPLDFGTW--TSMVELNLATNQLTKIPEDV-SGLVSLEVLILSNNLLK 438
+L +KDN L + + W ++EL+L +NQLT +P + GL LE L+LS N L
Sbjct: 451 RRLFLKDNGLVGIE-EQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLA 509
Query: 439 KLP-HGLGNLRKLRELDLEENKLESLPNE-IAYLKDLQKLVLTNNQLTTL---PRGIGHL 493
+LP LG L++ LD+ N+LE+LPN +A L L+ L L NN L T P G+ L
Sbjct: 510 ELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERL 569
Score = 101 bits (251), Expect = 2e-21
Identities = 135/469 (28%), Positives = 206/469 (43%), Gaps = 40/469 (8%)
Query: 108 SKRSIHILPSSIKELTQLTELYLYSNKLQSLP-AEVGCLVNLMTLALSENSLTSL-PDSL 165
S R++ LP + TQ L+L N L S+P A L +L L L L SL P +L
Sbjct: 99 SSRNLTRLPDGVPGGTQA--LWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQAL 156
Query: 166 DNLKKLRMLDLRHNKLREIPSVVY-RLDSLTTLYLRFNRITTVEKDI-KNLSKLSMLSIR 223
L+ L L L N+LR + + +L +L L NR++ +E + + L L L++
Sbjct: 157 LGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLG 216
Query: 224 ENKIKQLP-AEIGELCNLITLDVAHNQLEHL-PKEIGNCTQITNLDLQHNELLDLPDTIG 281
N + LP A L +L L +A N+L +L P ++ LDL N L + +
Sbjct: 217 WNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVF 276
Query: 282 -NLSSLSRLGLRYNRLSAI-PRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLA 339
L L +L L N ++A+ P + AL L+L +N ++ L E L+ L L L+
Sbjct: 277 VQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLS 336
Query: 340 RNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLD-F 398
N + L + HNRI ++ F L L + NQL + F
Sbjct: 337 HNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAF 396
Query: 399 GTWTSMVELNLATNQLTKIPEDV-SGLVSLEVLILSNNLLKKL-PHGLGNLRKLRELDLE 456
T++ +NL+ N L +PE V GL L L L + L ++ PH L LR L L+
Sbjct: 397 LGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLK 456
Query: 457 ENKLESLPNEIAY-LKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEI-G 514
+N L + + + L +L +L LT+NQL THLP +
Sbjct: 457 DNGLVGIEEQSLWGLAELLELDLTSNQL-----------------------THLPHRLFQ 493
Query: 515 TLENLEELYLNDNPNLHSLPFE-LALCSKLSIMSIENCPLSHLPPQIVA 562
L LE L L+ N L LP + L + + + + L LP ++A
Sbjct: 494 GLGKLEYLLLSRN-RLAELPADALGPLQRAFWLDVSHNRLEALPNSLLA 541
Score = 95.9 bits (237), Expect = 9e-20
Identities = 88/297 (29%), Positives = 153/297 (51%), Gaps = 11/297 (3%)
Query: 105 LDLSKRSIHILPSSI-KELTQLTELYLYSNKLQSL-PAEVGCLVNLMTLALSENSLTSL- 161
LDLS+ ++ + +++ +L +L +LYL N + ++ P L L L LS N + L
Sbjct: 261 LDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLL 320
Query: 162 PDSLDNLKKLRMLDLRHNKLREI-PSVVYRLDSLTTLYLRFNRITTV-EKDIKNLSKLSM 219
D+ L LR+L L HN + + P L L L L NRI + E+ + L +L +
Sbjct: 321 EDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEV 380
Query: 220 LSIRENKIKQLPAE--IGELCNLITLDVAHNQLEHLPKEI-GNCTQITNLDLQHNELLDL 276
L++ N+++++ A +G L N+ ++++ N L +LP+++ ++ +L L+ + L +
Sbjct: 381 LTLDHNQLQEVKAGAFLG-LTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRI 439
Query: 277 -PDTIGNLSSLSRLGLRYNRLSAIP-RSLAKCSALEELNLENNNISTLPESLLSSLVKLN 334
P T LS L RL L+ N L I +SL + L EL+L +N ++ LP L L KL
Sbjct: 440 RPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLE 499
Query: 335 SLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQL 391
L L+RN P + L++ HNR+ +P + + L L++++N L
Sbjct: 500 YLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSL 556
Score = 78.6 bits (192), Expect = 1e-14
Identities = 93/322 (28%), Positives = 136/322 (42%), Gaps = 33/322 (10%)
Query: 273 LLDLPDTIGNLSSLSRLGLRYNRLSAIP-RSLAKCSALEELNLENNNISTLPESLLSSLV 331
L LPD G L L N LS++P + S+L LNL+ + +L L L
Sbjct: 103 LTRLPD--GVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLE 160
Query: 332 KLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQL 391
L L L RN + +G + + SL + +NR++++ G+F L LN+ N L
Sbjct: 161 NLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSL 220
Query: 392 TSLP-LDFGTWTSMVELNLATNQLTKI-PEDVSGLVSLEVLILSNNLLKKL--------- 440
LP F S+ EL LA N+L + P SGL L L LS N L+ +
Sbjct: 221 AVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLP 280
Query: 441 ----------------PHGLGNLRKLRELDLEENKLES-LPNEIAYLKDLQKLVLTNNQL 483
P L+ LR LDL N++ L + L L+ L L++N +
Sbjct: 281 RLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAI 340
Query: 484 TTL-PRGIGHLTNLTHLGLGENLLTHLPE-EIGTLENLEELYLNDNPNLHSLPFELALCS 541
+L PR L L L LG N + L E L LE L L+ N +
Sbjct: 341 ASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLT 400
Query: 542 KLSIMSIENCPLSHLPPQIVAG 563
+++M++ L +LP Q+ G
Sbjct: 401 NVAVMNLSGNCLRNLPEQVFRG 422
>gi|4826772 insulin-like growth factor binding protein, acid labile
subunit isoform 2 precursor [Homo sapiens]
Length = 605
Score = 125 bits (313), Expect = 1e-28
Identities = 132/420 (31%), Positives = 198/420 (47%), Gaps = 45/420 (10%)
Query: 116 PSSIKELTQLTELYLYSNKLQSLPAEVGCLVN---LMTLALSENSLTSLPDSL-DNLKKL 171
P ++ L L L+L N+L+SL +G + L +L LS N L+ L D L + L L
Sbjct: 115 PQALLGLENLCHLHLERNQLRSLA--LGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSL 172
Query: 172 RMLDLRHNKLREIPSVVYR-LDSLTTLYLRFNRITTVEKDI-KNLSKLSMLSIRENKIKQ 229
L+L N L +P +R L SL L L NR+ ++ + L++L L + N ++
Sbjct: 173 WDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRA 232
Query: 230 LPAEIG-ELCNLITLDVAHNQLEHL-PKEIGNCTQITNLDLQHNELLDL-PDTIGNLSSL 286
+ A + +L L L + N + + P + LDL HN + L DT L L
Sbjct: 233 IKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGL 292
Query: 287 SRLGLRYNRLSAI-PRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQL 345
L L +N ++++ PR+ LEEL L +N I L E L +L LTL N Q
Sbjct: 293 RVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQE 352
Query: 346 YPVGG--------------------PSQ----FSTIYSLNMEHNRINKIPFGIFSRAKVL 381
G P Q ++SL++E + + +I F+ L
Sbjct: 353 VKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGL 412
Query: 382 SKLNMKDNQLTSLPLDFGTW--TSMVELNLATNQLTKIPEDV-SGLVSLEVLILSNNLLK 438
+L +KDN L + + W ++EL+L +NQLT +P + GL LE L+LS N L
Sbjct: 413 RRLFLKDNGLVGIE-EQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLA 471
Query: 439 KLP-HGLGNLRKLRELDLEENKLESLPNE-IAYLKDLQKLVLTNNQLTTL---PRGIGHL 493
+LP LG L++ LD+ N+LE+LPN +A L L+ L L NN L T P G+ L
Sbjct: 472 ELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERL 531
Score = 101 bits (251), Expect = 2e-21
Identities = 135/469 (28%), Positives = 206/469 (43%), Gaps = 40/469 (8%)
Query: 108 SKRSIHILPSSIKELTQLTELYLYSNKLQSLP-AEVGCLVNLMTLALSENSLTSL-PDSL 165
S R++ LP + TQ L+L N L S+P A L +L L L L SL P +L
Sbjct: 61 SSRNLTRLPDGVPGGTQA--LWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQAL 118
Query: 166 DNLKKLRMLDLRHNKLREIPSVVY-RLDSLTTLYLRFNRITTVEKDI-KNLSKLSMLSIR 223
L+ L L L N+LR + + +L +L L NR++ +E + + L L L++
Sbjct: 119 LGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLG 178
Query: 224 ENKIKQLP-AEIGELCNLITLDVAHNQLEHL-PKEIGNCTQITNLDLQHNELLDLPDTIG 281
N + LP A L +L L +A N+L +L P ++ LDL N L + +
Sbjct: 179 WNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVF 238
Query: 282 -NLSSLSRLGLRYNRLSAI-PRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLA 339
L L +L L N ++A+ P + AL L+L +N ++ L E L+ L L L+
Sbjct: 239 VQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLS 298
Query: 340 RNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLD-F 398
N + L + HNRI ++ F L L + NQL + F
Sbjct: 299 HNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAF 358
Query: 399 GTWTSMVELNLATNQLTKIPEDV-SGLVSLEVLILSNNLLKKL-PHGLGNLRKLRELDLE 456
T++ +NL+ N L +PE V GL L L L + L ++ PH L LR L L+
Sbjct: 359 LGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLK 418
Query: 457 ENKLESLPNEIAY-LKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEI-G 514
+N L + + + L +L +L LT+NQL THLP +
Sbjct: 419 DNGLVGIEEQSLWGLAELLELDLTSNQL-----------------------THLPHRLFQ 455
Query: 515 TLENLEELYLNDNPNLHSLPFE-LALCSKLSIMSIENCPLSHLPPQIVA 562
L LE L L+ N L LP + L + + + + L LP ++A
Sbjct: 456 GLGKLEYLLLSRN-RLAELPADALGPLQRAFWLDVSHNRLEALPNSLLA 503
Score = 95.9 bits (237), Expect = 9e-20
Identities = 88/297 (29%), Positives = 153/297 (51%), Gaps = 11/297 (3%)
Query: 105 LDLSKRSIHILPSSI-KELTQLTELYLYSNKLQSL-PAEVGCLVNLMTLALSENSLTSL- 161
LDLS+ ++ + +++ +L +L +LYL N + ++ P L L L LS N + L
Sbjct: 223 LDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLL 282
Query: 162 PDSLDNLKKLRMLDLRHNKLREI-PSVVYRLDSLTTLYLRFNRITTV-EKDIKNLSKLSM 219
D+ L LR+L L HN + + P L L L L NRI + E+ + L +L +
Sbjct: 283 EDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEV 342
Query: 220 LSIRENKIKQLPAE--IGELCNLITLDVAHNQLEHLPKEI-GNCTQITNLDLQHNELLDL 276
L++ N+++++ A +G L N+ ++++ N L +LP+++ ++ +L L+ + L +
Sbjct: 343 LTLDHNQLQEVKAGAFLG-LTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRI 401
Query: 277 -PDTIGNLSSLSRLGLRYNRLSAIP-RSLAKCSALEELNLENNNISTLPESLLSSLVKLN 334
P T LS L RL L+ N L I +SL + L EL+L +N ++ LP L L KL
Sbjct: 402 RPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLE 461
Query: 335 SLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQL 391
L L+RN P + L++ HNR+ +P + + L L++++N L
Sbjct: 462 YLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSL 518
Score = 78.6 bits (192), Expect = 1e-14
Identities = 93/322 (28%), Positives = 136/322 (42%), Gaps = 33/322 (10%)
Query: 273 LLDLPDTIGNLSSLSRLGLRYNRLSAIP-RSLAKCSALEELNLENNNISTLPESLLSSLV 331
L LPD G L L N LS++P + S+L LNL+ + +L L L
Sbjct: 65 LTRLPD--GVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLE 122
Query: 332 KLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQL 391
L L L RN + +G + + SL + +NR++++ G+F L LN+ N L
Sbjct: 123 NLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSL 182
Query: 392 TSLP-LDFGTWTSMVELNLATNQLTKI-PEDVSGLVSLEVLILSNNLLKKL--------- 440
LP F S+ EL LA N+L + P SGL L L LS N L+ +
Sbjct: 183 AVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLP 242
Query: 441 ----------------PHGLGNLRKLRELDLEENKLES-LPNEIAYLKDLQKLVLTNNQL 483
P L+ LR LDL N++ L + L L+ L L++N +
Sbjct: 243 RLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAI 302
Query: 484 TTL-PRGIGHLTNLTHLGLGENLLTHLPE-EIGTLENLEELYLNDNPNLHSLPFELALCS 541
+L PR L L L LG N + L E L LE L L+ N +
Sbjct: 303 ASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLT 362
Query: 542 KLSIMSIENCPLSHLPPQIVAG 563
+++M++ L +LP Q+ G
Sbjct: 363 NVAVMNLSGNCLRNLPEQVFRG 384
>gi|19923729 leucine rich repeat containing 8 family, member C [Homo
sapiens]
Length = 803
Score = 120 bits (300), Expect = 4e-27
Identities = 105/400 (26%), Positives = 191/400 (47%), Gaps = 41/400 (10%)
Query: 104 RLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPD 163
RL+L + LP ++ E+T+L L L K +PA + L NL L+L + S+
Sbjct: 425 RLELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSA 484
Query: 164 SLDNLKK-LRMLDLRHNKLREIPSVVYRLDSLTTLYL------RFNRITTVEKDIKNLSK 216
+L LK+ L++L ++ + +RE+P +Y L +L LYL +R T+E +++L
Sbjct: 485 ALSFLKENLKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNVTLE-SLRDLKS 543
Query: 217 LSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLP--KEIGNCTQITNLDLQHNELL 274
L +LSI+ N + ++P + ++ + + HN L + T +T L+L H +L
Sbjct: 544 LKILSIKSN-VSKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLE 602
Query: 275 DLPDTIGNLSSLSRLGLRYNRLSAIPR--SLAKCSALEELNLENNNISTLPESLLSSLVK 332
+P + +L SL L L+ N L +I S L L L +N+I+ +PE +
Sbjct: 603 RIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHI------ 656
Query: 333 LNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLT 392
+ +++ L+ HN+I +P +F K+ L++ N +
Sbjct: 657 -------------------KKLTSLERLSFSHNKIEVLPSHLFLCNKI-RYLDLSYNDIR 696
Query: 393 SLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRE 452
+P + G S+ ++ N++ +P+++ L+ L + N L L +GNL L
Sbjct: 697 FIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSY 756
Query: 453 LDLEENKLESLPNEIAYLKDLQK--LVLTNNQLTTLPRGI 490
LD++ N E LP E+ + L++ LV+ + TLP +
Sbjct: 757 LDVKGNHFEILPPELGDCRALKRAGLVVEDALFETLPSDV 796
Score = 112 bits (279), Expect = 1e-24
Identities = 113/409 (27%), Positives = 194/409 (47%), Gaps = 51/409 (12%)
Query: 158 LTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSK- 216
L+ LPD++ + +L+ L L K IP+ + +LD+L L L + + L +
Sbjct: 433 LSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAALSFLKEN 492
Query: 217 LSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDL 276
L +LS++ + +++LP + L NL L + L H D+ N L+
Sbjct: 493 LKVLSVKFDDMRELPPWMYGLRNLEELYLV-GSLSH--------------DISRNVTLE- 536
Query: 277 PDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSA-LEELNLENNNISTLPESLLSSLVKLNS 335
++ +L SL L ++ N +S IP+++ S+ L+++ + N+ + +L++L K+ +
Sbjct: 537 --SLRDLKSLKILSIKSN-VSKIPQAVVDVSSHLQKMCIHNDGTKLV---MLNNLKKMTN 590
Query: 336 LTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLP 395
LT L + H + +IP +FS L +L++K+N L S+
Sbjct: 591 LT---------------------ELELVHCDLERIPHAVFSLLS-LQELDLKENNLKSIE 628
Query: 396 --LDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLREL 453
+ F + L L N +T IPE + L SLE L S+N ++ LP L K+R L
Sbjct: 629 EIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHNKIEVLPSHLFLCNKIRYL 688
Query: 454 DLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEI 513
DL N + +P EI L+ LQ +T N++ +LP + L L +G+N L+ L +I
Sbjct: 689 DLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKI 748
Query: 514 GTLENLEELYLNDNPNLHSLPFELALCS--KLSIMSIENCPLSHLPPQI 560
G L L L + N + LP EL C K + + +E+ LP +
Sbjct: 749 GNLLFLSYLDVKGN-HFEILPPELGDCRALKRAGLVVEDALFETLPSDV 796
>gi|40217803 leucine rich repeat containing 8 family, member E [Homo
sapiens]
Length = 796
Score = 120 bits (300), Expect = 4e-27
Identities = 114/405 (28%), Positives = 181/405 (44%), Gaps = 21/405 (5%)
Query: 170 KLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQ 229
+L+ L+L H E + ++ L L + + + LS++ L +
Sbjct: 392 RLKQLNLNHEWTPEKLRQKLQRNAAGRLELALCMLPGLPDTVFELSEVESLRLEAICDIT 451
Query: 230 LPAEIGELCNLITLDVAHNQLEHLP--KEIGNCTQITNLDLQHNELLDLPDTIGNLSSLS 287
P + +L +L L + H+ LP ++ + + ++ EL ++P + L L
Sbjct: 452 FPPGLSQLVHLQELSLLHSPAR-LPFSLQVFLRDHLKVMRVKCEELREVPLWVFGLRGLE 510
Query: 288 RLGLRYNRLSAIPRSLAKCSALEELN--------LENNNISTLPESLLSSLVKLNSLTLA 339
L L P+ LA+ + LE L +N +P S+ L L+L
Sbjct: 511 ELHLE----GLFPQELARAATLESLRELKQLKVLSLRSNAGKVPASVTDVAGHLQRLSLH 566
Query: 340 RNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLP--LD 397
+ +L + + + + L + + +IP +FS L +L++KDN L S+ L
Sbjct: 567 NDGARLVALNSLKKLAALRELELVACGLERIPHAVFSLG-ALQELDLKDNHLRSIEEILS 625
Query: 398 FGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEE 457
F +V L L NQ+ +PE V L SLE L LS N L+ LP LG LR LD+
Sbjct: 626 FQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSH 685
Query: 458 NKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLE 517
N L SLP E+ L++LQ L L+ N L LP + L L LG+N L+ L +G L
Sbjct: 686 NGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALR 745
Query: 518 NLEELYLNDNPNLHSLPFELALCS--KLSIMSIENCPLSHLPPQI 560
L L L N L +LP EL C K + + +E+ LP ++
Sbjct: 746 ALSRLELKGN-RLEALPEELGNCGGLKKAGLLVEDTLYQGLPAEV 789
Score = 119 bits (298), Expect = 8e-27
Identities = 74/200 (37%), Positives = 112/200 (56%), Gaps = 2/200 (1%)
Query: 117 SSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPD--SLDNLKKLRML 174
+S+K+L L EL L + L+ +P V L L L L +N L S+ + S + +KL L
Sbjct: 576 NSLKKLAALRELELVACGLERIPHAVFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTL 635
Query: 175 DLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLPAEI 234
L HN++ +P V +L SL LYL +N++ T+ + S L +L + N + LP E+
Sbjct: 636 RLWHNQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEV 695
Query: 235 GELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRLGLRYN 294
G L NL L +++N LE LP+E+ C ++ L L N+L L +G L +LSRL L+ N
Sbjct: 696 GLLQNLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGN 755
Query: 295 RLSAIPRSLAKCSALEELNL 314
RL A+P L C L++ L
Sbjct: 756 RLEALPEELGNCGGLKKAGL 775
Score = 97.1 bits (240), Expect = 4e-20
Identities = 108/389 (27%), Positives = 182/389 (46%), Gaps = 26/389 (6%)
Query: 96 KCREENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSE 155
K + + RL+L+ + LP ++ EL+++ L L + + P + LV+L L+L
Sbjct: 410 KLQRNAAGRLELALCMLPGLPDTVFELSEVESLRLEAICDITFPPGLSQLVHLQELSLL- 468
Query: 156 NSLTSLPDSLDNLKK--LRMLDLRHNKLREIPSVVYRLDSLTTLYL------RFNRITTV 207
+S LP SL + L+++ ++ +LRE+P V+ L L L+L R T+
Sbjct: 469 HSPARLPFSLQVFLRDHLKVMRVKCEELREVPLWVFGLRGLEELHLEGLFPQELARAATL 528
Query: 208 EKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLP--KEIGNCTQITN 265
E ++ L +L +LS+R N K +PA + ++ + HN L + +
Sbjct: 529 E-SLRELKQLKVLSLRSNAGK-VPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALRE 586
Query: 266 LDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPR--SLAKCSALEELNLENNNISTLP 323
L+L L +P + +L +L L L+ N L +I S C L L L +N I+ +P
Sbjct: 587 LELVACGLERIPHAVFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVP 646
Query: 324 ESLLSSLVKLNSLTLARNCFQLYPVGGPSQF---STIYSLNMEHNRINKIPFGIFSRAKV 380
E + L L L L+ N + PSQ S + L++ HN ++ +P + +
Sbjct: 647 EH-VRKLRSLEQLYLSYNKLETL----PSQLGLCSGLRLLDVSHNGLHSLPPEV-GLLQN 700
Query: 381 LSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKL 440
L L + N L +LP + + L L NQL+++ V L +L L L N L+ L
Sbjct: 701 LQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEAL 760
Query: 441 PHGLGNLRKLRELDL--EENKLESLPNEI 467
P LGN L++ L E+ + LP E+
Sbjct: 761 PEELGNCGGLKKAGLLVEDTLYQGLPAEV 789
Score = 90.1 bits (222), Expect = 5e-18
Identities = 93/335 (27%), Positives = 152/335 (45%), Gaps = 25/335 (7%)
Query: 243 LDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRS 302
L++A L LP + +++ +L L+ + P + L L L L ++ + +P S
Sbjct: 419 LELALCMLPGLPDTVFELSEVESLRLEAICDITFPPGLSQLVHLQELSLLHSP-ARLPFS 477
Query: 303 L------------AKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGG 350
L KC L E+ L + L E L L L A L
Sbjct: 478 LQVFLRDHLKVMRVKCEELREVPLWVFGLRGLEELHLEGLFP-QELARAATLESL----- 531
Query: 351 PSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLD-FGTWTSMVELNL 409
+ + L++ N K+P + A L +L++ ++ + L+ ++ EL L
Sbjct: 532 -RELKQLKVLSLRSNA-GKVPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALRELEL 589
Query: 410 ATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLG--NLRKLRELDLEENKLESLPNEI 467
L +IP V L +L+ L L +N L+ + L + RKL L L N++ +P +
Sbjct: 590 VACGLERIPHAVFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHV 649
Query: 468 AYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDN 527
L+ L++L L+ N+L TLP +G + L L + N L LP E+G L+NL+ L L+ N
Sbjct: 650 RKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYN 709
Query: 528 PNLHSLPFELALCSKLSIMSIENCPLSHLPPQIVA 562
L +LP EL C KL + + + LS L P + A
Sbjct: 710 A-LEALPEELFFCRKLRTLLLGDNQLSQLSPHVGA 743
Score = 80.9 bits (198), Expect = 3e-15
Identities = 54/171 (31%), Positives = 88/171 (51%), Gaps = 4/171 (2%)
Query: 89 EVIKELNKCREENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNL 148
E I CR+ ++RL I +P +++L L +LYL NKL++LP+++G L
Sbjct: 621 EEILSFQHCRKLVTLRL--WHNQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGL 678
Query: 149 MTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVE 208
L +S N L SLP + L+ L+ L L +N L +P ++ L TL L N+++ +
Sbjct: 679 RLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLS 738
Query: 209 KDIKNLSKLSMLSIRENKIKQLPAEIGELCNL--ITLDVAHNQLEHLPKEI 257
+ L LS L ++ N+++ LP E+G L L V + LP E+
Sbjct: 739 PHVGALRALSRLELKGNRLEALPEELGNCGGLKKAGLLVEDTLYQGLPAEV 789
>gi|197333706 leucine rich repeat containing 8 family, member D
[Homo sapiens]
Length = 858
Score = 119 bits (299), Expect = 6e-27
Identities = 74/234 (31%), Positives = 131/234 (55%), Gaps = 10/234 (4%)
Query: 107 LSKRSIH------ILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTS 160
L+K IH ++ +S+K++ + EL L + +L+ +P + L NL L L N++ +
Sbjct: 613 LTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRT 672
Query: 161 LPD--SLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLS 218
+ + S +LK+L L L HNK+ IP + + +L +LY N++ ++ + +L KL
Sbjct: 673 IEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLR 732
Query: 219 MLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPD 278
L + N I +P EIG L NL L + N+++ LPK++ C ++ L+L N + LP+
Sbjct: 733 CLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPE 792
Query: 279 TIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEE--LNLENNNISTLPESLLSSL 330
+G LS L++L L+ N L +P L +C L++ L +E++ TLP + +L
Sbjct: 793 KVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPLEVKEAL 846
Score = 119 bits (298), Expect = 8e-27
Identities = 99/365 (27%), Positives = 178/365 (48%), Gaps = 24/365 (6%)
Query: 210 DIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCT------QI 263
D+ +L L + I E KI PA+I ++ NL L + H P ++ +
Sbjct: 488 DLTDLDVLKLELIPEAKI---PAKISQMTNLQELHLCH-----CPAKVEQTAFSFLRDHL 539
Query: 264 TNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLE----NNNI 319
L ++ ++ ++P + L +L L L N S + + S E +L+ +N+
Sbjct: 540 RCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNL 599
Query: 320 STLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAK 379
+ +P ++ L L + + +L + + + L +++ + +IP IFS +
Sbjct: 600 TKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSN 659
Query: 380 VLSKLNMKDNQLTSLP--LDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLL 437
L +L++K N + ++ + F + L L N++ IP ++ + +LE L SNN L
Sbjct: 660 -LQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKL 718
Query: 438 KKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLT 497
+ LP + +L+KLR LD+ N + +P EI L++LQ L +T N++ LP+ + L
Sbjct: 719 ESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLR 778
Query: 498 HLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSLPFELALCS--KLSIMSIENCPLSH 555
L LG+N +T LPE++G L L +L L N L LP +L C K S + +E+
Sbjct: 779 TLNLGQNCITSLPEKVGQLSQLTQLELKGN-CLDRLPAQLGQCRMLKKSGLVVEDHLFDT 837
Query: 556 LPPQI 560
LP ++
Sbjct: 838 LPLEV 842
Score = 115 bits (289), Expect = 8e-26
Identities = 102/401 (25%), Positives = 190/401 (47%), Gaps = 38/401 (9%)
Query: 109 KRSIHI-----LPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPD 163
K+ +H+ +P ++ +LT L L L +PA++ + NL L L
Sbjct: 471 KQELHLFMLSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQT 530
Query: 164 SLDNLKK-LRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEK-----DIKNLSKL 217
+ L+ LR L ++ + EIP+ VY L +L LYL N + K ++ L L
Sbjct: 531 AFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHL 590
Query: 218 SMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLP 277
+L ++ N + ++P+ I ++ +T V HN +LL L
Sbjct: 591 KILHVKSN-LTKVPSNITDVAPHLTKLVIHN--------------------DGTKLLVL- 628
Query: 278 DTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESL-LSSLVKLNSL 336
+++ + +++ L L+ L IP ++ S L+EL+L++NNI T+ E + L +L L
Sbjct: 629 NSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCL 688
Query: 337 TLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPL 396
L N P + + SL +N++ +P +FS K L L++ N ++ +P+
Sbjct: 689 KLWHNKIVTIP-PSITHVKNLESLYFSNNKLESLPVAVFSLQK-LRCLDVSYNNISMIPI 746
Query: 397 DFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLE 456
+ G ++ L++ N++ +P+ + + L L L N + LP +G L +L +L+L+
Sbjct: 747 EIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELK 806
Query: 457 ENKLESLPNEIAYLKDLQK--LVLTNNQLTTLPRGIGHLTN 495
N L+ LP ++ + L+K LV+ ++ TLP + N
Sbjct: 807 GNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPLEVKEALN 847
Score = 80.9 bits (198), Expect = 3e-15
Identities = 55/178 (30%), Positives = 96/178 (53%), Gaps = 5/178 (2%)
Query: 84 KSSNAEVIKELNKCREENSMR-LDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEV 142
KS+N I+E+ + + L L I +P SI + L LY +NKL+SLP V
Sbjct: 666 KSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAV 725
Query: 143 GCLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFN 202
L L L +S N+++ +P + L+ L+ L + NK+ +P +++ L TL L N
Sbjct: 726 FSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQN 785
Query: 203 RITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLIT---LDVAHNQLEHLPKEI 257
IT++ + + LS+L+ L ++ N + +LPA++G+ C ++ L V + + LP E+
Sbjct: 786 CITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQ-CRMLKKSGLVVEDHLFDTLPLEV 842
Score = 34.7 bits (78), Expect = 0.25
Identities = 47/198 (23%), Positives = 90/198 (45%), Gaps = 23/198 (11%)
Query: 352 SQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLAT 411
+ F+ + + +++++ FG+F LS+++ +N+L + L+ + +++
Sbjct: 414 NDFAFLLHMVDQYDQLYSKRFGVF-----LSEVS--ENKLREISLNHEWTFEKLRQHISR 466
Query: 412 N----------QLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLE 461
N L+ +P+ V L L+VL L K+P + + L+EL L +
Sbjct: 467 NAQDKQELHLFMLSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAK 526
Query: 462 SLPNEIAYLKD-LQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLE 520
++L+D L+ L + + +P + L NL L L NL + + IG LE+L
Sbjct: 527 VEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIG-LESLR 585
Query: 521 EL----YLNDNPNLHSLP 534
EL L+ NL +P
Sbjct: 586 ELRHLKILHVKSNLTKVP 603
>gi|34222199 leucine rich repeat containing 8 family, member D [Homo
sapiens]
Length = 858
Score = 119 bits (299), Expect = 6e-27
Identities = 74/234 (31%), Positives = 131/234 (55%), Gaps = 10/234 (4%)
Query: 107 LSKRSIH------ILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTS 160
L+K IH ++ +S+K++ + EL L + +L+ +P + L NL L L N++ +
Sbjct: 613 LTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRT 672
Query: 161 LPD--SLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLS 218
+ + S +LK+L L L HNK+ IP + + +L +LY N++ ++ + +L KL
Sbjct: 673 IEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLR 732
Query: 219 MLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPD 278
L + N I +P EIG L NL L + N+++ LPK++ C ++ L+L N + LP+
Sbjct: 733 CLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPE 792
Query: 279 TIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEE--LNLENNNISTLPESLLSSL 330
+G LS L++L L+ N L +P L +C L++ L +E++ TLP + +L
Sbjct: 793 KVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPLEVKEAL 846
Score = 119 bits (298), Expect = 8e-27
Identities = 99/365 (27%), Positives = 178/365 (48%), Gaps = 24/365 (6%)
Query: 210 DIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCT------QI 263
D+ +L L + I E KI PA+I ++ NL L + H P ++ +
Sbjct: 488 DLTDLDVLKLELIPEAKI---PAKISQMTNLQELHLCH-----CPAKVEQTAFSFLRDHL 539
Query: 264 TNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLE----NNNI 319
L ++ ++ ++P + L +L L L N S + + S E +L+ +N+
Sbjct: 540 RCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNL 599
Query: 320 STLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAK 379
+ +P ++ L L + + +L + + + L +++ + +IP IFS +
Sbjct: 600 TKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSN 659
Query: 380 VLSKLNMKDNQLTSLP--LDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLL 437
L +L++K N + ++ + F + L L N++ IP ++ + +LE L SNN L
Sbjct: 660 -LQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKL 718
Query: 438 KKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLT 497
+ LP + +L+KLR LD+ N + +P EI L++LQ L +T N++ LP+ + L
Sbjct: 719 ESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLR 778
Query: 498 HLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSLPFELALCS--KLSIMSIENCPLSH 555
L LG+N +T LPE++G L L +L L N L LP +L C K S + +E+
Sbjct: 779 TLNLGQNCITSLPEKVGQLSQLTQLELKGN-CLDRLPAQLGQCRMLKKSGLVVEDHLFDT 837
Query: 556 LPPQI 560
LP ++
Sbjct: 838 LPLEV 842
Score = 115 bits (289), Expect = 8e-26
Identities = 102/401 (25%), Positives = 190/401 (47%), Gaps = 38/401 (9%)
Query: 109 KRSIHI-----LPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPD 163
K+ +H+ +P ++ +LT L L L +PA++ + NL L L
Sbjct: 471 KQELHLFMLSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQT 530
Query: 164 SLDNLKK-LRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEK-----DIKNLSKL 217
+ L+ LR L ++ + EIP+ VY L +L LYL N + K ++ L L
Sbjct: 531 AFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHL 590
Query: 218 SMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLP 277
+L ++ N + ++P+ I ++ +T V HN +LL L
Sbjct: 591 KILHVKSN-LTKVPSNITDVAPHLTKLVIHN--------------------DGTKLLVL- 628
Query: 278 DTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESL-LSSLVKLNSL 336
+++ + +++ L L+ L IP ++ S L+EL+L++NNI T+ E + L +L L
Sbjct: 629 NSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCL 688
Query: 337 TLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPL 396
L N P + + SL +N++ +P +FS K L L++ N ++ +P+
Sbjct: 689 KLWHNKIVTIP-PSITHVKNLESLYFSNNKLESLPVAVFSLQK-LRCLDVSYNNISMIPI 746
Query: 397 DFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLE 456
+ G ++ L++ N++ +P+ + + L L L N + LP +G L +L +L+L+
Sbjct: 747 EIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELK 806
Query: 457 ENKLESLPNEIAYLKDLQK--LVLTNNQLTTLPRGIGHLTN 495
N L+ LP ++ + L+K LV+ ++ TLP + N
Sbjct: 807 GNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPLEVKEALN 847
Score = 80.9 bits (198), Expect = 3e-15
Identities = 55/178 (30%), Positives = 96/178 (53%), Gaps = 5/178 (2%)
Query: 84 KSSNAEVIKELNKCREENSMR-LDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEV 142
KS+N I+E+ + + L L I +P SI + L LY +NKL+SLP V
Sbjct: 666 KSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAV 725
Query: 143 GCLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFN 202
L L L +S N+++ +P + L+ L+ L + NK+ +P +++ L TL L N
Sbjct: 726 FSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQN 785
Query: 203 RITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLIT---LDVAHNQLEHLPKEI 257
IT++ + + LS+L+ L ++ N + +LPA++G+ C ++ L V + + LP E+
Sbjct: 786 CITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQ-CRMLKKSGLVVEDHLFDTLPLEV 842
Score = 34.7 bits (78), Expect = 0.25
Identities = 47/198 (23%), Positives = 90/198 (45%), Gaps = 23/198 (11%)
Query: 352 SQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLAT 411
+ F+ + + +++++ FG+F LS+++ +N+L + L+ + +++
Sbjct: 414 NDFAFLLHMVDQYDQLYSKRFGVF-----LSEVS--ENKLREISLNHEWTFEKLRQHISR 466
Query: 412 N----------QLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLE 461
N L+ +P+ V L L+VL L K+P + + L+EL L +
Sbjct: 467 NAQDKQELHLFMLSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAK 526
Query: 462 SLPNEIAYLKD-LQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLE 520
++L+D L+ L + + +P + L NL L L NL + + IG LE+L
Sbjct: 527 VEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIG-LESLR 585
Query: 521 EL----YLNDNPNLHSLP 534
EL L+ NL +P
Sbjct: 586 ELRHLKILHVKSNLTKVP 603
>gi|4504379 leucine-rich repeat-containing G protein-coupled
receptor 5 [Homo sapiens]
Length = 907
Score = 118 bits (295), Expect = 2e-26
Identities = 116/388 (29%), Positives = 188/388 (48%), Gaps = 16/388 (4%)
Query: 105 LDLSKRSI-HILPSSIKELTQLTELYLYSNKLQSLP--AEVGCLVNLMTLALSENSLTSL 161
LDLS +I +LP+ + L L EL L N L +P A G L +L L L N L +
Sbjct: 71 LDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTG-LYSLKVLMLQNNQLRHV 129
Query: 162 P-DSLDNLKKLRMLDLRHNKLREIPSVVYR-LDSLTTLYLRFNRITTVE-KDIKNLSKLS 218
P ++L NL+ L+ L L N + +P + L SL L+L N +T + + ++LS L
Sbjct: 130 PTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQ 189
Query: 219 MLSIRENKIKQLPA-EIGELCNLITLDVAHNQLEHLPKE-IGNCTQITNLDLQHNELLDL 276
+++ NKI +P G L +L+ L + +N++ L K+ + LDL +N L +
Sbjct: 190 AMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEF 249
Query: 277 PDTIGNLSSLSRLGLRYNRLSAIP-RSLAKCSALEELNLENNNISTLPESLLSSLVKLNS 335
P I LS+L LG N + +IP ++ +L ++ +N I + S L +L +
Sbjct: 250 PTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRT 309
Query: 336 LTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLP 395
LTL Q+ + + + SL + +I+ +P + ++ L L++ N L LP
Sbjct: 310 LTL-NGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLP 368
Query: 396 LDFGTWTSMVELNLATNQLTKIPEDV-SGLVSLEVLILSNNLLKKL-PHGLGNLRKLREL 453
F + +++L N++ +I D L+SL L L+ N + + P+ L L +L
Sbjct: 369 -SFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKL 427
Query: 454 DLEENKLESLPNEIAYLKDLQKLVLTNN 481
DL N L S P I L L L LT N
Sbjct: 428 DLSSNLLSSFP--ITGLHGLTHLKLTGN 453
Score = 95.1 bits (235), Expect = 2e-19
Identities = 94/320 (29%), Positives = 154/320 (48%), Gaps = 14/320 (4%)
Query: 218 SMLSIRENKIKQL-PAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLD---LQHNEL 273
S L + N I QL P + L L L +A N L ++PK G T + +L LQ+N+L
Sbjct: 69 SYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPK--GAFTGLYSLKVLMLQNNQL 126
Query: 274 LDLP-DTIGNLSSLSRLGLRYNRLSAIPRS-LAKCSALEELNLENNNISTLPESLLSSLV 331
+P + + NL SL L L N +S +P S + +L L L++N ++ +P SL
Sbjct: 127 RHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLS 186
Query: 332 KLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQL 391
L ++TLA N P S++ L++ +NRI+ + F L L++ N L
Sbjct: 187 ALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNL 246
Query: 392 TSLPLDFGTWTSMVELNLATNQLTKIPEDV-SGLVSLEVLILSNNLLKKLPH-GLGNLRK 449
P T +++ EL +N + IPE G SL + +N ++ + +L +
Sbjct: 247 DEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPE 306
Query: 450 LRELDLE-ENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGI-GHLTNLTHLGLGENLLT 507
LR L L +++ P ++ +L+ L LT Q+++LP+ + L NL L L NLL
Sbjct: 307 LRTLTLNGASQITEFP-DLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLE 365
Query: 508 HLPEEIGTLENLEELYLNDN 527
LP + L+++ L N
Sbjct: 366 DLP-SFSVCQKLQKIDLRHN 384
Score = 37.4 bits (85), Expect = 0.038
Identities = 32/117 (27%), Positives = 52/117 (44%), Gaps = 2/117 (1%)
Query: 448 RKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLT 507
R L +D + L LP+ ++ L + NN LP + L L L L N LT
Sbjct: 45 RMLLRVDCSDLGLSELPSNLSVFTSYLDLSM-NNISQLLPNPLPSLRFLEELRLAGNALT 103
Query: 508 HLPEEIGT-LENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLSHLPPQIVAG 563
++P+ T L +L+ L L +N H L L + ++ +S++PP +G
Sbjct: 104 YIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSG 160
>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
Length = 545
Score = 118 bits (295), Expect = 2e-26
Identities = 124/412 (30%), Positives = 195/412 (47%), Gaps = 34/412 (8%)
Query: 126 TELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIP 185
T L L + Q P +GC + + S+ L ++P + K
Sbjct: 10 TSLLLLARPAQ--PCPMGCDCFVQEVFCSDEELATVPLDIPPYTK--------------- 52
Query: 186 SVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDV 245
++++ S TTL R NL+K+ L+ + + + P G L L L+V
Sbjct: 53 NIIFVETSFTTLETR------AFGSNPNLTKVVFLNTQLCQFR--PDAFGGLPRLEDLEV 104
Query: 246 AHNQLEHLPKEI-GNCTQITNLDLQHNELLDLPDTI-GNLSSLSRLGLRYNRLSAIPRSL 303
+ +L I N T + L L N L LP+ + +L++L L L+ N+L A+PR L
Sbjct: 105 TGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRL 164
Query: 304 AK-CSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNM 362
+ + L+ LNL N ++ LPE L L L +L L+ N P G + ++ L +
Sbjct: 165 FQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFL 224
Query: 363 EHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLD-FGTWTSMVELNLATNQLTKIPEDV 421
+ N I+++P +FS+ L +L ++ N +T LPL F + ++ L+L N L +P +
Sbjct: 225 DSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGL 284
Query: 422 -SGLVSLEVLILSNNLLKKLPHG-LGNLRKLRELDLEENKLESLPNEI-AYLKDLQKLVL 478
+ L L L++N L+ + G +L LR L L N + LP I L++L KL L
Sbjct: 285 FAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYL 344
Query: 479 TNNQLTTL-PRGIGHLTNLTHLGLGENLLTHLPEEI-GTLENLEELYLNDNP 528
+N LT L P +L+ L L L +N LT LPE I T NL L L+ NP
Sbjct: 345 GSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGNP 396
Score = 98.6 bits (244), Expect = 1e-20
Identities = 87/266 (32%), Positives = 136/266 (51%), Gaps = 12/266 (4%)
Query: 104 RLDLSKRSIHILPSSI-KELTQLTELYLYSNKLQSLPAEV-GCLVNLMTLALSENSLTSL 161
+L L+ + LP + + L L L+L N+LQ+LP + L +L TL L++N L L
Sbjct: 125 KLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQL 184
Query: 162 PDSLDN-LKKLRMLDLRHNKLREIPSVVY-RLDSLTTLYLRFNRITTVEKDI-KNLSKLS 218
P+ L + L L+ L L +N L +P V+ +L SL L+L N I+ + + L L
Sbjct: 185 PEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLE 244
Query: 219 MLSIRENKIKQLPAEI-GELCNLITLDVAHNQLEHLPKEI-GNCTQITNLDLQHNELLDL 276
L ++ N I LP I L NL L + N L LP + + + L L HN+L +
Sbjct: 245 RLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETV 304
Query: 277 PD-TIGNLSSLSRLGLRYNRLSAIPRSLAK-CSALEELNLENNNISTLPESLLSSLVKLN 334
+ T +LS+L L L YN ++ +P + + L +L L +NN++ L +L +L KL
Sbjct: 305 AEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLE 364
Query: 335 SLTLARNCFQLYPVGGPSQFSTIYSL 360
L+L++N P G F T Y+L
Sbjct: 365 LLSLSKNQLTTLPEG---IFDTNYNL 387
Score = 67.4 bits (163), Expect = 3e-11
Identities = 69/197 (35%), Positives = 98/197 (49%), Gaps = 11/197 (5%)
Query: 105 LDLSKRSIHILPSSI-KELTQLTELYLYSNKLQSLPAEV-GCLVNLMTLALSENSLTSLP 162
L LS ++ LP + +L L EL+L SN + LP +V L L L L N++T LP
Sbjct: 198 LKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLP 257
Query: 163 DSL-DNLKKLRMLDLRHNKLREIPSVVY-RLDSLTTLYLRFNRITTV-EKDIKNLSKLSM 219
S+ +L L L L+ N LR +P+ ++ L L L N++ TV E +LS L
Sbjct: 258 LSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRS 317
Query: 220 LSIRENKIKQLPAEI-GELCNLITLDVAHNQLEHL-PKEIGNCTQITNLDLQHNELLDLP 277
L + N I LPA I +L L+ L + N L L P N +++ L L N+L LP
Sbjct: 318 LMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLP 377
Query: 278 ----DTIGNLSSLSRLG 290
DT NL +L+ G
Sbjct: 378 EGIFDTNYNLFNLALHG 394
>gi|21389431 leucine rich repeat containing 39 [Homo sapiens]
Length = 335
Score = 116 bits (291), Expect = 5e-26
Identities = 76/232 (32%), Positives = 120/232 (51%), Gaps = 4/232 (1%)
Query: 98 REENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENS 157
RE+ + L + K LPSS+ +L QL E L+ L +P +G NL+ L LS N+
Sbjct: 58 REDGRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNT 117
Query: 158 LTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNR-ITTVEKDIKNLSK 216
++ +P + L +L+ L L +NK++ +P + SL L L NR I + +++ NL K
Sbjct: 118 ISEIPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLK 177
Query: 217 LSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDL 276
L+ L + N +P + + L LD+ N+LE LP I + L LQ NE+ L
Sbjct: 178 LTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCL 237
Query: 277 PDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNIS---TLPES 325
P TI N+ +L L L N+L IP + + + L +N +N + +LP S
Sbjct: 238 PQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLKLKVSLPPS 289
Score = 95.9 bits (237), Expect = 9e-20
Identities = 70/248 (28%), Positives = 123/248 (49%), Gaps = 7/248 (2%)
Query: 157 SLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSK 216
SLT L + + +L + + + +PS + +L+ L L + + + I
Sbjct: 48 SLTKLREKVTREDGRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQN 107
Query: 217 LSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHN-ELLD 275
L +L + N I ++P IG L L L +++N+++ +PKE+ NC + L+L N ++ D
Sbjct: 108 LIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICD 167
Query: 276 LPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNS 335
LP + NL L+ L L N + IP ++ ALE L++ +N + LP++ + + L++
Sbjct: 168 LPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDT-IERMQNLHT 226
Query: 336 LTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQL---T 392
L L RN P S + +L + +N++ IP + A L +N +DN L
Sbjct: 227 LWLQRNEITCLP-QTISNMKNLGTLVLSNNKLQDIPVCMEEMAN-LRFVNFRDNPLKLKV 284
Query: 393 SLPLDFGT 400
SLP GT
Sbjct: 285 SLPPSEGT 292
Score = 95.9 bits (237), Expect = 9e-20
Identities = 71/220 (32%), Positives = 114/220 (51%), Gaps = 8/220 (3%)
Query: 312 LNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYP--VGGPSQFSTIYSLNMEHNRINK 369
L +E TLP SLL L +L L R P +G +F + L++ N I++
Sbjct: 65 LKIEKEEWKTLPSSLLK-LNQLQEWQLHRTGLLKIPEFIG---RFQNLIVLDLSRNTISE 120
Query: 370 IPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQ-LTKIPEDVSGLVSLE 428
IP GI + L +L + N++ ++P + S+ +L LA N+ + +P+++S L+ L
Sbjct: 121 IPPGIGLLTR-LQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLT 179
Query: 429 VLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPR 488
L LS N +P + N+ L LD+ NKLE LP+ I +++L L L N++T LP+
Sbjct: 180 HLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQ 239
Query: 489 GIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNP 528
I ++ NL L L N L +P + + NL + DNP
Sbjct: 240 TISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNP 279
Score = 89.7 bits (221), Expect = 7e-18
Identities = 79/288 (27%), Positives = 127/288 (44%), Gaps = 54/288 (18%)
Query: 180 KLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCN 239
KLRE V R D L + T+ + L++L + + ++P IG N
Sbjct: 51 KLRE---KVTREDGRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQN 107
Query: 240 LITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAI 299
LI LD++ N + +P IG T++ L L +N++ +P + N +SL +L L NR
Sbjct: 108 LIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNR---- 163
Query: 300 PRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYS 359
+I LP+ LS+L+KL L L+ N F P+
Sbjct: 164 ------------------DICDLPQE-LSNLLKLTHLDLSMNDFTTIPLA---------V 195
Query: 360 LNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPE 419
LNM L L+M N+L LP ++ L L N++T +P+
Sbjct: 196 LNM----------------PALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQ 239
Query: 420 DVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLE---SLP 464
+S + +L L+LSNN L+ +P + + LR ++ +N L+ SLP
Sbjct: 240 TISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLKLKVSLP 287
Score = 89.7 bits (221), Expect = 7e-18
Identities = 67/226 (29%), Positives = 110/226 (48%), Gaps = 7/226 (3%)
Query: 299 IPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIY 358
+P SL K + L+E L + +PE + L L L+RN P G + +
Sbjct: 75 LPSSLLKLNQLQEWQLHRTGLLKIPE-FIGRFQNLIVLDLSRNTISEIPPG-IGLLTRLQ 132
Query: 359 SLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQ-LTSLPLDFGTWTSMVELNLATNQLTKI 417
L + +N+I +P + S L KL + N+ + LP + + L+L+ N T I
Sbjct: 133 ELILSYNKIKTVPKEL-SNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTI 191
Query: 418 PEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLV 477
P V + +LE L + +N L++LP + ++ L L L+ N++ LP I+ +K+L LV
Sbjct: 192 PLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLV 251
Query: 478 LTNNQLTTLPRGIGHLTNLTHLGLGEN---LLTHLPEEIGTLENLE 520
L+NN+L +P + + NL + +N L LP GT E E
Sbjct: 252 LSNNKLQDIPVCMEEMANLRFVNFRDNPLKLKVSLPPSEGTDEEEE 297
Score = 64.7 bits (156), Expect = 2e-10
Identities = 45/144 (31%), Positives = 72/144 (50%)
Query: 414 LTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDL 473
LTK+ E V+ +L + K LP L L +L+E L L +P I ++L
Sbjct: 49 LTKLREKVTREDGRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNL 108
Query: 474 QKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSL 533
L L+ N ++ +P GIG LT L L L N + +P+E+ +LE+L L N ++ L
Sbjct: 109 IVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDL 168
Query: 534 PFELALCSKLSIMSIENCPLSHLP 557
P EL+ KL+ + + + +P
Sbjct: 169 PQELSNLLKLTHLDLSMNDFTTIP 192
Score = 58.5 bits (140), Expect = 2e-08
Identities = 43/157 (27%), Positives = 74/157 (47%), Gaps = 2/157 (1%)
Query: 405 VELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLP 464
V L + + +P + L L+ L L K+P +G + L LDL N + +P
Sbjct: 63 VILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIP 122
Query: 465 NEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENL-LTHLPEEIGTLENLEELY 523
I L LQ+L+L+ N++ T+P+ + + +L L L N + LP+E+ L L L
Sbjct: 123 PGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLD 182
Query: 524 LNDNPNLHSLPFELALCSKLSIMSIENCPLSHLPPQI 560
L+ N + ++P + L + + + L LP I
Sbjct: 183 LSMN-DFTTIPLAVLNMPALEWLDMGSNKLEQLPDTI 218
>gi|62912470 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 1 [Homo sapiens]
Length = 967
Score = 115 bits (287), Expect = 1e-25
Identities = 124/462 (26%), Positives = 196/462 (42%), Gaps = 64/462 (13%)
Query: 75 PNPAPGTRKKSSNAEVIKELNKCREENSM-RLDLSKRSIHILPSSIKELTQLTELYLYSN 133
P P PG + C+E+ M D S+ + +P + LT +L + +N
Sbjct: 26 PQPGPGPTACPAPCH-------CQEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSM-NN 77
Query: 134 KLQSLPAEVGCLVNLMTLALSENSLTSLP-DSLDNLKKLRMLDLRHNKLREIPS-VVYRL 191
+ P L L L LS N L+ +P + L L++L L++N+L IP+ ++ L
Sbjct: 78 LTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWEL 137
Query: 192 DSLTTLYLRFNRITTV-EKDIKNLSKLSMLSIRENKIKQLPAE-IGELCNLITLDVAHNQ 249
SL +L L N I+ V E+ + LS L L + +N + ++P + L L + +A N+
Sbjct: 138 PSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNR 197
Query: 250 LEHLPK-EIGNCTQITNLDLQHNELLDL-PDTIGNLSSLSRLGLRYNRLSAIPRSLAKCS 307
+ H+P N T + L L +N + L + L +L L L YN+L P ++
Sbjct: 198 ISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLG 257
Query: 308 ALEELNLENNNISTLPESLLSSLVKLNSLT--------LARNCFQLYP------VGGPSQ 353
L+EL NNNI +PE L ++ + R+ FQ P + G
Sbjct: 258 RLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMD 317
Query: 354 F---------STIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSM 404
+++ L + I +P G+ + L L + NQ+ LP +
Sbjct: 318 IQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELP-SLHRCQKL 376
Query: 405 VELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESL- 463
E+ L N++ +I D L L+ LDL N + S+
Sbjct: 377 EEIGLQHNRIWEIGADT----------------------FSQLSSLQALDLSWNAIRSIH 414
Query: 464 PNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENL 505
P + L L KL LT+NQLTTLP + L L HL L NL
Sbjct: 415 PEAFSTLHSLVKLDLTDNQLTTLP--LAGLGGLMHLKLKGNL 454
Score = 94.0 bits (232), Expect = 3e-19
Identities = 100/386 (25%), Positives = 170/386 (44%), Gaps = 59/386 (15%)
Query: 204 ITTVEKDIKNLSKLSMLSIRENKIKQL-PAEIGELCNLITLDVAHNQLEHLPKE-IGNCT 261
++ V D+ L+ + L + N + +L P L L L ++ N L H+P +
Sbjct: 57 LSAVPGDLDPLT--AYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLY 114
Query: 262 QITNLDLQHNELLDLP-DTIGNLSSLSRLGLRYNRLSAIP-RSLAKCSALEELNLENNNI 319
+ L LQ+N+L +P + + L SL L L N +S +P RS S+L L L++N +
Sbjct: 115 SLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNAL 174
Query: 320 STLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAK 379
+ +P L++L L ++TLA N P +++ L++ +NRI + F
Sbjct: 175 TEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLH 234
Query: 380 VLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPE-------------------- 419
L L++ N+L P+ T + EL N + IPE
Sbjct: 235 NLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQ 294
Query: 420 ----------------------------DVSGLVSLEVLILSNNLLKKLPHGL-GNLRKL 450
D+ G SLE+L L+ ++ LP G+ L +L
Sbjct: 295 FVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRL 354
Query: 451 RELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRG-IGHLTNLTHLGLGENLLTHL 509
R L+L N++E LP+ + + L+++ L +N++ + L++L L L N + +
Sbjct: 355 RVLELSHNQIEELPS-LHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSI 413
Query: 510 -PEEIGTLENLEELYLNDNPNLHSLP 534
PE TL +L +L L DN L +LP
Sbjct: 414 HPEAFSTLHSLVKLDLTDN-QLTTLP 438
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.132 0.365
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,341,636
Number of Sequences: 37866
Number of extensions: 954949
Number of successful extensions: 9184
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 234
Number of HSP's successfully gapped in prelim test: 228
Number of HSP's that attempted gapping in prelim test: 4117
Number of HSP's gapped (non-prelim): 2117
length of query: 582
length of database: 18,247,518
effective HSP length: 108
effective length of query: 474
effective length of database: 14,157,990
effective search space: 6710887260
effective search space used: 6710887260
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.