Search of human proteins with 40807475

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|40807475 PML-RARA regulated adaptor molecule 1 [Homo
sapiens]
         (669 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|40807475 PML-RARA regulated adaptor molecule 1 [Homo sapiens]     1389   0.0  
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ...   116   6e-26
gi|110349719 titin isoform N2-A [Homo sapiens]                        111   2e-24
gi|61966919 hypothetical protein LOC442444 [Homo sapiens]             103   4e-22
gi|148727245 thioredoxin domain-containing 2 isoform 1 [Homo sap...   103   7e-22
gi|148727319 thioredoxin domain-containing 2 isoform 2 [Homo sap...   103   7e-22
gi|42516570 thioredoxin domain-containing 2 isoform 1 [Homo sapi...   103   7e-22
gi|41281612 zinc finger protein 828 [Homo sapiens]                     98   3e-20
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    97   5e-20
gi|40788007 FYN binding protein (FYB-120/130) isoform 2 [Homo sa...    94   5e-19
gi|42476118 FYN binding protein (FYB-120/130) isoform 1 [Homo sa...    94   5e-19
gi|47132519 Ras association and pleckstrin homology domains 1 is...    93   7e-19
gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens]     93   7e-19
gi|150170670 piccolo isoform 2 [Homo sapiens]                          90   6e-18
gi|150378539 piccolo isoform 1 [Homo sapiens]                          90   6e-18
gi|41349482 proline-rich protein BstNI subfamily 1 isoform 1 pre...    89   1e-17
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    89   2e-17
gi|160707881 formin 2 [Homo sapiens]                                   89   2e-17
gi|189181724 proteoglycan 4 isoform D [Homo sapiens]                   85   2e-16
gi|189181722 proteoglycan 4 isoform C [Homo sapiens]                   85   2e-16
gi|189181720 proteoglycan 4 isoform B [Homo sapiens]                   85   2e-16
gi|67190163 proteoglycan 4 isoform A [Homo sapiens]                    85   2e-16
gi|163965366 nascent polypeptide-associated complex alpha subuni...    85   2e-16
gi|19718731 bromodomain-containing protein 4 isoform long [Homo ...    84   3e-16
gi|24308073 protein tyrosine phosphatase, non-receptor type 23 [...    83   7e-16
gi|150417989 cyclin K isoform 1 [Homo sapiens]                         77   7e-14
gi|239754327 PREDICTED: chromosome 6 open reading frame 132 [Hom...    76   9e-14
gi|239748855 PREDICTED: chromosome 6 open reading frame 132 [Hom...    76   9e-14
gi|239742884 PREDICTED: hypothetical protein LOC647024 [Homo sap...    76   9e-14
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]     76   1e-13

>gi|40807475 PML-RARA regulated adaptor molecule 1 [Homo sapiens]
          Length = 669

 Score = 1389 bits (3596), Expect = 0.0
 Identities = 669/669 (100%), Positives = 669/669 (100%)

Query: 1   MAHHLPAAMESHQDFRSIKAKFQASQPEPSDLPKKPPKPEFGKLKKFSQPELSEHPKKAP 60
           MAHHLPAAMESHQDFRSIKAKFQASQPEPSDLPKKPPKPEFGKLKKFSQPELSEHPKKAP
Sbjct: 1   MAHHLPAAMESHQDFRSIKAKFQASQPEPSDLPKKPPKPEFGKLKKFSQPELSEHPKKAP 60

Query: 61  LPEFGAVSLKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPS 120
           LPEFGAVSLKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPS
Sbjct: 61  LPEFGAVSLKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPS 120

Query: 121 KLELSDLSKKFPQLGATPFPRKPLQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARPP 180
           KLELSDLSKKFPQLGATPFPRKPLQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARPP
Sbjct: 121 KLELSDLSKKFPQLGATPFPRKPLQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARPP 180

Query: 181 SEPKSGAFPRKLWQPEAGEATPRSPQPELSTFPKKPAQPEFNVYPKKPPQPQVGGLPKKS 240
           SEPKSGAFPRKLWQPEAGEATPRSPQPELSTFPKKPAQPEFNVYPKKPPQPQVGGLPKKS
Sbjct: 181 SEPKSGAFPRKLWQPEAGEATPRSPQPELSTFPKKPAQPEFNVYPKKPPQPQVGGLPKKS 240

Query: 241 VPQPEFSEAAQTPLWKPQSSEPKRDSSAFPKKASQPPLSDFPKKPPQPELGDLTRTSSEP 300
           VPQPEFSEAAQTPLWKPQSSEPKRDSSAFPKKASQPPLSDFPKKPPQPELGDLTRTSSEP
Sbjct: 241 VPQPEFSEAAQTPLWKPQSSEPKRDSSAFPKKASQPPLSDFPKKPPQPELGDLTRTSSEP 300

Query: 301 EVSVLPKRPRPAEFKALSKKPPQPELGGLPRTSSEPEFNSLPRKLLQPERRGPPRKFSQP 360
           EVSVLPKRPRPAEFKALSKKPPQPELGGLPRTSSEPEFNSLPRKLLQPERRGPPRKFSQP
Sbjct: 301 EVSVLPKRPRPAEFKALSKKPPQPELGGLPRTSSEPEFNSLPRKLLQPERRGPPRKFSQP 360

Query: 361 EPSAVLKRHPQPEFFGDLPRKPPLPSSASESSLPAAVAGFSSRHPLSPGFGAAGTPRWRS 420
           EPSAVLKRHPQPEFFGDLPRKPPLPSSASESSLPAAVAGFSSRHPLSPGFGAAGTPRWRS
Sbjct: 361 EPSAVLKRHPQPEFFGDLPRKPPLPSSASESSLPAAVAGFSSRHPLSPGFGAAGTPRWRS 420

Query: 421 GGLVHSGGARPGLRPSHPPRRRPLPPASSLGHPPAKPPLPPGPVDMQSFRRPSAASIDLR 480
           GGLVHSGGARPGLRPSHPPRRRPLPPASSLGHPPAKPPLPPGPVDMQSFRRPSAASIDLR
Sbjct: 421 GGLVHSGGARPGLRPSHPPRRRPLPPASSLGHPPAKPPLPPGPVDMQSFRRPSAASIDLR 480

Query: 481 RTRSAAGLHFQDRQPEDIPVPDEIYELYDDVEPRDDSSPSPKGRDEAPSVQQAARRPPQD 540
           RTRSAAGLHFQDRQPEDIPVPDEIYELYDDVEPRDDSSPSPKGRDEAPSVQQAARRPPQD
Sbjct: 481 RTRSAAGLHFQDRQPEDIPVPDEIYELYDDVEPRDDSSPSPKGRDEAPSVQQAARRPPQD 540

Query: 541 PALRKEKDPQPQQLPPMDPKLLKQLRKAEKAEREFRKKFKFEGEIVVHTKMMIDPNAKTR 600
           PALRKEKDPQPQQLPPMDPKLLKQLRKAEKAEREFRKKFKFEGEIVVHTKMMIDPNAKTR
Sbjct: 541 PALRKEKDPQPQQLPPMDPKLLKQLRKAEKAEREFRKKFKFEGEIVVHTKMMIDPNAKTR 600

Query: 601 RGGGKHLGIRRGEILEVIEFTSNEEMLCRDPKGKYGYVPRTALLPLETEVYDDVDFCDPL 660
           RGGGKHLGIRRGEILEVIEFTSNEEMLCRDPKGKYGYVPRTALLPLETEVYDDVDFCDPL
Sbjct: 601 RGGGKHLGIRRGEILEVIEFTSNEEMLCRDPKGKYGYVPRTALLPLETEVYDDVDFCDPL 660

Query: 661 ENQPLPLGR 669
           ENQPLPLGR
Sbjct: 661 ENQPLPLGR 669


>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
           sapiens]
          Length = 5537

 Score =  116 bits (291), Expect = 6e-26
 Identities = 133/442 (30%), Positives = 170/442 (38%), Gaps = 79/442 (17%)

Query: 27  PEPSDLPKKPPKPEFGKL-KKFSQPELSEHPKKAPLPEFGAVSLKPPPPEVTDLPKKPPP 85
           P P + P  PP PE  +L   F +  LS  P+++PL          PPPE + L    PP
Sbjct: 583 PPPEESPMSPP-PEASRLFPPFEESPLSPPPEESPL---------SPPPEASRL---SPP 629

Query: 86  PEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPSKLELSDLSKKFPQLGATPFPRKPLQ 145
           PE  D P  PPP E        PPPEV+ L   P    LS   ++ P   + P    P  
Sbjct: 630 PE--DSPMSPPPEE----SPMSPPPEVSRLSPLPVVSRLSPPPEESPL--SPPPEESPTS 681

Query: 146 PEVGEAPLKASLPEPGAPARKPLQPDELSHPARPPSEPKSGAFPRK----LWQPEAGEAT 201
           P     P +AS   P  P   P  P     PA PP E    + P +    L  PE  +  
Sbjct: 682 P-----PPEASRLSP-PPEDSPTSPPPEDSPASPPPEDSLMSLPLEESPLLPLPEEPQLC 735

Query: 202 PRSPQPELSTFPKKPAQPEFNVYPKKPPQPQVGGLPKKSVPQPEFSEAAQTPLWKPQSSE 261
           PRS  P LS  P++         P   P+P+          +P  S  A+ P   PQ  E
Sbjct: 736 PRSEGPHLSPRPEE---------PHLSPRPE----------EPHLSPQAEEPHLSPQPEE 776

Query: 262 PKRDSSAFPKKASQPPLSDFPKKPPQPELGDLTRTSSEPEVSVLPKRPRPAEFKALSKKP 321
           P     A P++    P ++ P   PQPE   L+  + EP +S +P+ P       LS   
Sbjct: 777 P--CLCAVPEEPHLSPQAEGPHLSPQPEELHLSPQTEEPHLSPVPEEP------CLS--- 825

Query: 322 PQPELGGLPRTSSEPEFNSLPRKL-LQPERRGPPRKFSQPEPSAVLKRHPQPEFFGDLPR 380
           PQPE   L   S EP  +  P +  L PE   PP      +P     + P PE   +LP 
Sbjct: 826 PQPEESHLSPQSEEPCLSPRPEESHLSPELEKPPLSPRPEKPPEEPGQCPAPE---ELPL 882

Query: 381 KPPLPSSASESSLPAAVAGFSSRHPLSPGFGAAGTPRWRSGGLVHSGGARPGLRPS---H 437
            PP    +    L           PLSP              L  S    P L P     
Sbjct: 883 FPPPGEPSLSPLLGEPALSEPGEPPLSP----------LPEELPLSPSGEPSLSPQLMPP 932

Query: 438 PPRRRPLPPASSLGHPPAKPPL 459
            P   PL P  +   PPA  PL
Sbjct: 933 DPLPPPLSPIITAAAPPALSPL 954



 Score =  111 bits (277), Expect = 2e-24
 Identities = 156/576 (27%), Positives = 204/576 (35%), Gaps = 104/576 (18%)

Query: 25  SQPEPSDLPKKPP---------KPEFGKLKKFSQPELSEHPKKA-PLPEFGAVSLKPP-- 72
           S PEP D P   P         +P+ G +      E      +A PL + G V L+P   
Sbjct: 373 SPPEPGDTPTDEPDALYVACQGQPKGGHVTSMQPKEPGPLQCEAKPLGKAG-VQLEPQLE 431

Query: 73  PPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPSKLELSDLSKKFP 132
            P   ++P  PPP E    P  PPP E        PPPE + L   P +L  S L +   
Sbjct: 432 APLNEEMPLLPPPEES---PLSPPPEE----SPTSPPPEASRLSPPPEELPASPLPEALH 484

Query: 133 QLGATPFPRKPLQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARPPSEPKSGAFPRKL 192
              + P    PL P   E+PL    P P +    PL+   LS P   P  P         
Sbjct: 485 L--SRPLEESPLSPPPEESPLS---PPPESSPFSPLEESPLSPPEESPPSPAL------- 532

Query: 193 WQPEAGEATPRSPQPELSTFPKKPAQPEFNVYPKKPPQPQVGGLPKKSVPQPEFSEAAQT 252
                   TP SP PE S     P  P F   P  PP  ++      + P PE S  +  
Sbjct: 533 -------ETPLSPPPEAS-----PLSPPFEESPLSPPPEEL-----PTSPPPEASRLSPP 575

Query: 253 PLWKPQSSEPKRDSSAFPKKASQ--PPLSDFPKKPPQPELG-----DLTRTSSEPEVSVL 305
           P   P S  P+    + P +AS+  PP  + P  PP  E       + +R S  PE S  
Sbjct: 576 PEESPMSPPPEESPMSPPPEASRLFPPFEESPLSPPPEESPLSPPPEASRLSPPPEDS-- 633

Query: 306 PKRPRPAEFKALSKKPPQPELGGLP---RTSSEPEFNSLPRKLLQPERRGPPRKFSQPEP 362
           P  P P E   +S  P    L  LP   R S  PE + L           PP +     P
Sbjct: 634 PMSPPPEE-SPMSPPPEVSRLSPLPVVSRLSPPPEESPLSP---------PPEESPTSPP 683

Query: 363 SAVLKRHPQPEFFGDLPRKPPLPSSASESSLPAAVAGFSSRHPLSPGFGAAGTPRWRSGG 422
               +  P PE   D P  PP     S +S P   +  S     SP       P+     
Sbjct: 684 PEASRLSPPPE---DSPTSPP--PEDSPASPPPEDSLMSLPLEESPLLPLPEEPQL---- 734

Query: 423 LVHSGGARPGLRPSHPPRRRPLPPASSLGHPPAKPPLPPGP-------VDMQSFRRPSAA 475
              S G     RP  P    P P    L     +P L P P       V  +    P A 
Sbjct: 735 CPRSEGPHLSPRPEEP-HLSPRPEEPHLSPQAEEPHLSPQPEEPCLCAVPEEPHLSPQAE 793

Query: 476 SIDLRRTRSAAGLHFQDRQPEDIPVPDEI----YELYDDVEPRDDS---SPSPKGRD--- 525
              L        L  Q  +P   PVP+E           + P+ +    SP P+      
Sbjct: 794 GPHLSPQPEELHLSPQTEEPHLSPVPEEPCLSPQPEESHLSPQSEEPCLSPRPEESHLSP 853

Query: 526 --EAPSVQQAARRPPQDPALRKEKDPQPQQLPPMDP 559
             E P +     +PP++P     + P P++LP   P
Sbjct: 854 ELEKPPLSPRPEKPPEEPG----QCPAPEELPLFPP 885



 Score =  109 bits (273), Expect = 7e-24
 Identities = 151/572 (26%), Positives = 204/572 (35%), Gaps = 109/572 (19%)

Query: 27  PEPSDLPKKPPKPEFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPP------PEVTDLP 80
           P P + P  PP PE        +  LS   +  P P      L PPP      P   + P
Sbjct: 496 PPPEESPLSPP-PESSPFSPLEESPLSPPEESPPSPAL-ETPLSPPPEASPLSPPFEESP 553

Query: 81  KKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPSKLELS---DLSKKFPQLGAT 137
             PPP E   LP  PPP    +  +  PPPE + +   P +  +S   + S+ FP     
Sbjct: 554 LSPPPEE---LPTSPPP----EASRLSPPPEESPMSPPPEESPMSPPPEASRLFP----- 601

Query: 138 PFPRKPLQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARPPSEPKSGAFPRKLWQPEA 197
           PF   PL P   E+PL    P P A    P   D    P  PP E    + P     PE 
Sbjct: 602 PFEESPLSPPPEESPLS---PPPEASRLSPPPEDS---PMSPPPEESPMSPP-----PEV 650

Query: 198 GEATPRSPQPELSTFPKK-PAQPEFNVYPKKPPQPQVGGLPKKSVPQPEFSEAAQTPLWK 256
              +P      LS  P++ P  P     P  PP P+   L     P PE S  +  P   
Sbjct: 651 SRLSPLPVVSRLSPPPEESPLSPPPEESPTSPP-PEASRLS----PPPEDSPTSPPPEDS 705

Query: 257 PQSSEPKRDSSAFPKKASQPPLSDFPKKP---PQPELGDLTRTSSEPEVSVLPKRPR--- 310
           P S  P+    + P + S  PL   P++P   P+ E   L+    EP +S  P+ P    
Sbjct: 706 PASPPPEDSLMSLPLEES--PLLPLPEEPQLCPRSEGPHLSPRPEEPHLSPRPEEPHLSP 763

Query: 311 PAEFKALSKKPPQPELGGLPRT------SSEPEFNSLPRKL-LQPERRGPPRKFSQPEPS 363
            AE   LS +P +P L  +P        +  P  +  P +L L P+   P       EP 
Sbjct: 764 QAEEPHLSPQPEEPCLCAVPEEPHLSPQAEGPHLSPQPEELHLSPQTEEPHLSPVPEEPC 823

Query: 364 AVLKRHPQPEFFGDLPRKPPLPSSASESSLPAAVAGFSSRHPLSPGFGAAGTPRWRSGGL 423
             L   P+         +P L     ES L   +     + PLSP               
Sbjct: 824 --LSPQPEESHLSPQSEEPCLSPRPEESHLSPEL----EKPPLSP--------------- 862

Query: 424 VHSGGARPGLRPSHPPRRRPLPPASSLGHPPAKPPLPP--GPVDMQSFRRPSAASIDLRR 481
                 RP  +P   P + P P    L  PP +P L P  G   +     P  + +    
Sbjct: 863 ------RPE-KPPEEPGQCPAPEELPLFPPPGEPSLSPLLGEPALSEPGEPPLSPLPEEL 915

Query: 482 TRSAAG---LHFQDRQPEDIPVP-------------DEIYELYDDVEPRDDSSPSPKGRD 525
             S +G   L  Q   P+ +P P               + EL      + DS P      
Sbjct: 916 PLSPSGEPSLSPQLMPPDPLPPPLSPIITAAAPPALSPLGELEYPFGAKGDSDP------ 969

Query: 526 EAPSVQQAARRPPQDPALRKEKDPQPQQLPPM 557
           E+P        P   P      DP+P  +PPM
Sbjct: 970 ESPLAAPILETPISPPPEANCTDPEP--VPPM 999



 Score =  100 bits (248), Expect = 6e-21
 Identities = 138/498 (27%), Positives = 174/498 (34%), Gaps = 86/498 (17%)

Query: 73  PPEVTDLPKKPPPPEVTDLPKKPPPPEVTDL-PKKPPPPEVTDLPKKPSKLELSDLSKKF 131
           PPE  D P   P         +P    VT + PK+P P +    P   + ++L       
Sbjct: 374 PPEPGDTPTDEPDALYVACQGQPKGGHVTSMQPKEPGPLQCEAKPLGKAGVQLE------ 427

Query: 132 PQLGATPFPRKPLQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARPPSEPKSGAFPRK 191
           PQL A      PL P   E+PL    P P      P  P E S  + PP E  +   P  
Sbjct: 428 PQLEAPLNEEMPLLPPPEESPLS---PPPEESPTSP--PPEASRLSPPPEELPASPLPEA 482

Query: 192 LWQPEAGEATPRSPQPELSTFPKKPAQPEFNVYPKKPPQPQVGGLPKKSVPQPEFSEAAQ 251
           L      E +P SP PE S     P    F+   + P  P     P++S P P    A +
Sbjct: 483 LHLSRPLEESPLSPPPEESPLSPPPESSPFSPLEESPLSP-----PEESPPSP----ALE 533

Query: 252 TPLWKPQSSEPKRDSSAFPKKASQPPLSDFPKKPPQPELGDLTRTSSEPEVSVLPKRPRP 311
           TPL  P  + P   S  F +    PP  + P  PP     + +R S  PE S  P  P P
Sbjct: 534 TPLSPPPEASPL--SPPFEESPLSPPPEELPTSPPP----EASRLSPPPEES--PMSPPP 585

Query: 312 AEFKALSKKPPQPELGGLPRTSSEPEFNSLPRKLLQPERRGPPRKFSQPEPSAVLKRHPQ 371
            E    S   P PE   L      P F   P   L P    PP +     P    +  P 
Sbjct: 586 EE----SPMSPPPEASRL-----FPPFEESP---LSP----PPEESPLSPPPEASRLSPP 629

Query: 372 PEFFGDLPRKPPLPSSASESSLPAAVAGFSSRHPLSPGFGAAGTPRWRSGGLVHSGGARP 431
           PE   D P  P  P   S  S P  V+  S   PL P       P   S          P
Sbjct: 630 PE---DSPMSP--PPEESPMSPPPEVSRLS---PL-PVVSRLSPPPEES----------P 670

Query: 432 GLRPSHPPRRRPLPPASSLGHPPAKPPLPPGPVDMQSFRRPSAASIDLRRTRSAAGLHFQ 491
              P       P P AS L  PP   P  P P D  +   P  + + L    S       
Sbjct: 671 LSPPPEESPTSPPPEASRLSPPPEDSPTSPPPEDSPASPPPEDSLMSLPLEESPL----- 725

Query: 492 DRQPEDIPVPDEIYELYDDVEPRDDSSPSPKGRDEAPSVQQAARRPPQDP-ALRKEKDPQ 550
                 +P+P+E       + PR +  P    R E P +      P   P A      PQ
Sbjct: 726 ------LPLPEE-----PQLCPRSE-GPHLSPRPEEPHLSPRPEEPHLSPQAEEPHLSPQ 773

Query: 551 PQQ----LPPMDPKLLKQ 564
           P++      P +P L  Q
Sbjct: 774 PEEPCLCAVPEEPHLSPQ 791



 Score = 87.4 bits (215), Expect = 4e-17
 Identities = 119/433 (27%), Positives = 174/433 (40%), Gaps = 63/433 (14%)

Query: 27   PEPSDLPKKPPKPEFGKLKKFSQ-PELSEHPKKAPLPEFGAVSLKPPPPEVTDLPKKP-- 83
            P P + P  PP PE  +L        LS  P+++PL      S   PPPE + L   P  
Sbjct: 637  PPPEESPMSPP-PEVSRLSPLPVVSRLSPPPEESPLSPPPEESPTSPPPEASRLSPPPED 695

Query: 84   ----PPPEVTDLPKKPPPPE-----------VTDLPKKP------------PPPEVTDLP 116
                PPPE  D P  PPP +           +  LP++P            P PE   L 
Sbjct: 696  SPTSPPPE--DSPASPPPEDSLMSLPLEESPLLPLPEEPQLCPRSEGPHLSPRPEEPHLS 753

Query: 117  KKPSKLELSDLSKKFPQLGATPFPRKPLQPEVGEAPLKASLPEPGAPARKPLQPDELSHP 176
             +P +  LS  +++ P L  +P P +P    V E P  +  P+   P   P QP+EL H 
Sbjct: 754  PRPEEPHLSPQAEE-PHL--SPQPEEPCLCAVPEEPHLS--PQAEGPHLSP-QPEEL-HL 806

Query: 177  ARPPSEPKSGAFPRKLW---QPEAGEATPRSPQPELSTFPKKP------AQPEFNVYPKK 227
            +    EP     P +     QPE    +P+S +P LS  P++        +P  +  P+K
Sbjct: 807  SPQTEEPHLSPVPEEPCLSPQPEESHLSPQSEEPCLSPRPEESHLSPELEKPPLSPRPEK 866

Query: 228  PPQ-PQVGGLPKKSVPQPEFSEAAQTPLW-KPQSSEPKRDS-SAFPKK-----ASQPPLS 279
            PP+ P     P++    P   E + +PL  +P  SEP     S  P++     + +P LS
Sbjct: 867  PPEEPGQCPAPEELPLFPPPGEPSLSPLLGEPALSEPGEPPLSPLPEELPLSPSGEPSLS 926

Query: 280  D--FPKKPPQPELGDLTRTSSEPEVSVLPKRPRPAEFKALSKKPPQPELGGLPRT--SSE 335
                P  P  P L  +   ++ P +S L +   P   K  S  P  P    +  T  S  
Sbjct: 927  PQLMPPDPLPPPLSPIITAAAPPALSPLGELEYPFGAKGDSD-PESPLAAPILETPISPP 985

Query: 336  PEFNSLPRKLLQPERRGPPRKFSQPEPSAVLKRHPQPEFFGDLPRKPPLPSSASESSLPA 395
            PE N    + + P    PP   S   P++ +   P P     L +   +P ++  S    
Sbjct: 986  PEANCTDPEPVPPMIL-PPSPGSPVGPASPILMEPLPPQCSPLLQHSLVPQNSPPSQCSP 1044

Query: 396  AVAGFSSRHPLSP 408
                 S   PLSP
Sbjct: 1045 PALPLSVPSPLSP 1057



 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 113/441 (25%), Positives = 155/441 (35%), Gaps = 81/441 (18%)

Query: 71   PPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPP--PPEVTDLPKKPSKLELSDLS 128
            PP P  T  P +PP    +  P    P E    P   P   P   D   KP    L +L+
Sbjct: 2197 PPYPSPTGAPAQPPMLGASSRPGAGQPGEFHTTPPGTPRHQPSTPDPFLKPRCPSLDNLA 2256

Query: 129  -----------KKFPQLGATPFPRKPLQPEVGEAPLKASLPEPGAP-------------- 163
                          P L   PF       EV +  L AS P  G P              
Sbjct: 2257 VPESPGVGGGKASEPLLSPPPFGESRKALEVKKEELGASSPSYGPPNLGFVDSPSSGTHL 2316

Query: 164  -ARKPLQPDELSHPARPPS---EPKSGAFPRKLWQPEAGEATPRSP--QPEL---STFPK 214
               +   PD    P  P +   EP+S     +  +P   +A   SP   P++    ++  
Sbjct: 2317 GGLELKTPDVFKAPLTPRASQVEPQSPGLGLRPQEPPPAQALAPSPPSHPDIFRPGSYTD 2376

Query: 215  KPAQPEFNVYPKKPPQPQVGGLPKKSVPQPEFS---------EAAQTPLW-KPQSSEPKR 264
              AQP     P+ PP      LP +S+P   FS          ++Q+PL  +P S+E   
Sbjct: 2377 PYAQPPLTPRPQPPPPESCCALPPRSLPSDPFSRVPASPQSQSSSQSPLTPRPLSAEAFC 2436

Query: 265  DSSAFPKKASQPPLSDFPKKPPQPELGDLTRTSSEPEVSV-LPKRPRPAE--FKALSKKP 321
             S   P+  S  P S  P +P           S +P   +  P RP+P E  FKA S   
Sbjct: 2437 PSPVTPRFQSPDPYSRPPSRP----------QSRDPFAPLHKPPRPQPPEVAFKAGSLAH 2486

Query: 322  PQPELGGLPRTSSEPEFNSLPRKLLQPERRGPPRKFSQPEPSAVL-----KRHPQPEFFG 376
                 GG P          L  K+   +   PP     P   A +      R   P+  G
Sbjct: 2487 TSLGAGGFPAALPAGPAGELHAKVPSGQ---PPNFVRSPGTGAFVGTPSPMRFTFPQAVG 2543

Query: 377  DLPRKPPLPS---------SASESSLPAAVAGFSSRHPLSPG-FGAAGTPRWRSGGLVHS 426
            +   KPP+P          ++     P      S+ + ++ G F  +G+P   S G   S
Sbjct: 2544 EPSLKPPVPQPGLPPPHGINSHFGPGPTLGKPQSTNYTVATGNFHPSGSPLGPSSG---S 2600

Query: 427  GGARPGLRPSHPPRRRPLPPA 447
             G   GL P  PP   P PPA
Sbjct: 2601 TGESYGLSPLRPPSVLP-PPA 2620



 Score = 53.1 bits (126), Expect = 8e-07
 Identities = 119/480 (24%), Positives = 154/480 (32%), Gaps = 98/480 (20%)

Query: 75   EVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPSKLELSDLSKKFPQL 134
            +V D+ +K   P +  L   P P  +   P    P      P  P+ L  S      P  
Sbjct: 2089 KVGDIARKTDRPAL-HLRIPPQPGALGSPPPAAAPTIFIGSPTTPAGLSTSADGFLKPPA 2147

Query: 135  GATPFPRKPLQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARPPSEPKSGAFPRKLWQ 194
            G+ P P  P     GE  LK  LP P  PA+ P Q      PA P  EP+          
Sbjct: 2148 GSVPGPDSP-----GELFLK--LP-PQVPAQVPSQDPFGLAPAYP-LEPRF--------- 2189

Query: 195  PEAGEATPRSPQPELSTFPKKPAQPEFNVYPKKPPQPQVGGLPKKSVPQPEFSEAAQTPL 254
            P A    P  P P  +     PAQP       +P   Q G         P    +   P 
Sbjct: 2190 PTAPPTYPPYPSPTGA-----PAQPPMLGASSRPGAGQPGEFHTTPPGTPRHQPSTPDPF 2244

Query: 255  WKPQSSEPKRDSSAFPK-------KASQPPLSDFPKKPPQPELGDLTRTSSEPEVSVLPK 307
             KP+   P  D+ A P+       KAS+P LS     PP  E         E        
Sbjct: 2245 LKPRC--PSLDNLAVPESPGVGGGKASEPLLSP----PPFGESRKALEVKKE-------- 2290

Query: 308  RPRPAEFKALSKKPPQPELGGLPRTSSEPEFNSLPRKLLQPERRGPPRKFSQPEPSAVLK 367
                 E  A S     P LG +   SS      L  K         P  F  P      +
Sbjct: 2291 -----ELGASSPSYGPPNLGFVDSPSSGTHLGGLELKT--------PDVFKAPLTPRASQ 2337

Query: 368  RHPQPEFFGDLPRKPPLPSSASESSLPAAVAGFSSRHPLSPGFGAAGTPRWRSGGLVHSG 427
              PQ    G  P++PP P+ A   S P+        HP            +R G      
Sbjct: 2338 VEPQSPGLGLRPQEPP-PAQALAPSPPS--------HP----------DIFRPGSYTD-- 2376

Query: 428  GARPGLRPSHPPRRRPLPPASSLGHPPAKPPLPP---GPVDMQSFRRPSAASIDLRRTRS 484
               P  +P   PR +P PP S    PP   P  P    P   QS  + S+ S    R  S
Sbjct: 2377 ---PYAQPPLTPRPQPPPPESCCALPPRSLPSDPFSRVPASPQS--QSSSQSPLTPRPLS 2431

Query: 485  AAGLHFQDRQPEDIPVPDEIYELYDDVEPRDDSSPSPKGRDEAPSVQQAARRPPQDPALR 544
            A               P  +   +   +P       P+ RD    + +  R  P + A +
Sbjct: 2432 AEAF-----------CPSPVTPRFQSPDPYSRPPSRPQSRDPFAPLHKPPRPQPPEVAFK 2480



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 85/375 (22%), Positives = 128/375 (34%), Gaps = 86/375 (22%)

Query: 27   PEPSDLPKKPP------KPEFGK--LKKFSQPELSEHPKKAPLPEFGAVSLKPP------ 72
            P P +LP  PP       P  G+  L +  +P LS  P++ PL   G  SL P       
Sbjct: 875  PAPEELPLFPPPGEPSLSPLLGEPALSEPGEPPLSPLPEELPLSPSGEPSLSPQLMPPDP 934

Query: 73   -------------PPEVTDL--------------PKKPPPPEVTDLPKKPPPPEVTDLPK 105
                         PP ++ L              P+ P    + + P   PPPE      
Sbjct: 935  LPPPLSPIITAAAPPALSPLGELEYPFGAKGDSDPESPLAAPILETPIS-PPPEANCTDP 993

Query: 106  KPPPPEVTDLPKKPSKLELSDLSKKFPQLGATPFPRKPLQPEVGEAPLKASLPEPGAPAR 165
            +P PP +  LP  P            P   A+P   +PL P+       + +P+   P++
Sbjct: 994  EPVPPMI--LPPSPGS----------PVGPASPILMEPLPPQCSPLLQHSLVPQNSPPSQ 1041

Query: 166  --KPLQPDELSHPARPPSEPKSGAFPRKLWQPEAGEAT-PRSPQPELSTFPKKPAQPEFN 222
               P  P  +  P  P  +    +   +L + E  + + P  P  E S     P+     
Sbjct: 1042 CSPPALPLSVPSPLSPIGKVVGVSDEAELHEMETEKVSEPECPALEPSATSPLPSPMGDL 1101

Query: 223  VYPKKPPQPQV---GGLPKKSVP---------QPE--------FSEAAQTP-LWKPQSSE 261
              P   P P +    GL + + P         QPE         SE   +P L  P+   
Sbjct: 1102 SCPAPSPAPALDDFSGLGEDTAPLDGIDAPGSQPEPGQTPGSLASELKGSPVLLDPEELA 1161

Query: 262  PKRDSSAFPK------KASQPPLSDFPKKPPQPELGDLTRTSSEPEVSVLPKRPRPAEFK 315
            P      +P+      + S     + P+ P  P    L ++    E+S L +    A F 
Sbjct: 1162 PVTPMEVYPECKQTAGQGSPCEEQEEPRAPVAPTPPTLIKSDIVNEISNLSQGDASASFP 1221

Query: 316  ALSK--KPPQPELGG 328
                    P PE GG
Sbjct: 1222 GSEPLLGSPDPEGGG 1236



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 114/484 (23%), Positives = 162/484 (33%), Gaps = 90/484 (18%)

Query: 4    HLPAAMESHQDFRSIKAKFQASQPEPSDLPKKPPKPEFGKLKKF--SQPELSEHP--KKA 59
            HL    +       ++ + Q SQ      P + P  +   L+     QP+L   P  +  
Sbjct: 4213 HLSPQQQQQLQALLMQRQLQQSQAVRQTPPYQEPGTQTSPLQGLLGCQPQLGGFPGPQTG 4272

Query: 60   PLPEFGAVSLKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKP 119
            PL E GA   +P  P     P+ P PP          P   T      PPP     PK+P
Sbjct: 4273 PLQELGA-GPRPQGP-----PRLPAPPGALSTGPVLGPVHPT------PPPSSPQEPKRP 4320

Query: 120  SKLELSDLSKKFPQLGATPFPRKPLQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARP 179
            S+L               P P   L  E    P     P+P  P  +P  P  +S  A  
Sbjct: 4321 SQL---------------PSPSSQLPTEAQLPPTHPGTPKPQGPTLEP-PPGRVSPAAAQ 4364

Query: 180  PSEP--KSGAFPRKLWQPEAGEATPRSPQPELSTFPKKPAQPEFNVYP-------KKPPQ 230
             ++     G  P   W P    A  + P+ + S  P    Q    V P       K+ P+
Sbjct: 4365 LADTLFSKGLGP---WDPPDNLAETQKPE-QSSLVPGHLDQVNGQVVPEASQLSIKQEPR 4420

Query: 231  PQVGGLPKKSVPQPEFSEAAQTPLWKPQSSEPKRDSSAFPKKASQPPLSDFPKKPPQPEL 290
             +   L  +SV +    EA   P+  P +S                  +      P+ E 
Sbjct: 4421 EEPCALGAQSVKR----EANGEPIGAPGTS------------------NHLLLAGPRSEA 4458

Query: 291  GDLTRTSSEPEVSVLPKRPRPAE-FKALSKKPPQPELGGLPR----TSSEPEFNSLPRKL 345
            G L         +V     R +E  +A        +L GL +    T S  E ++  RK 
Sbjct: 4459 GHLLLQKLLRAKNVQLSTGRGSEGLRAEINGHIDSKLAGLEQKLQGTPSNKE-DAAARKP 4517

Query: 346  LQPERRGPPRKFSQPEPSAVLKRHPQPEFFGDLPRKPPLPSSASESSL-----PAAVAGF 400
            L P+    P++  +     V  R    +  G    +  L     E SL     PA  A F
Sbjct: 4518 LTPK----PKRVQKASDRLVSSRKKLRKEDGVRASEALLKQLKQELSLLPLTEPAITANF 4573

Query: 401  SSRHPLSPGFGAAGTPRWRSGGLVHSGGARPGLRPSHPPRRRPLPPASSLGHPPAKP-PL 459
            S   P   G    G  + R       G    G  P+ P     L   ++L +PP  P  L
Sbjct: 4574 SLFAPFGSGCPVNGQSQLR-------GAFGSGALPTGPDYYSQLLTKNNLSNPPTPPSSL 4626

Query: 460  PPGP 463
            PP P
Sbjct: 4627 PPTP 4630



 Score = 37.4 bits (85), Expect = 0.045
 Identities = 135/580 (23%), Positives = 192/580 (33%), Gaps = 169/580 (29%)

Query: 26   QPEPSDL-----PKKPPKPEFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPPPEVTDLP 80
            QP P +      P+  P   F ++    Q + S      P P   A +  P P  VT   
Sbjct: 2388 QPPPPESCCALPPRSLPSDPFSRVPASPQSQSSSQSPLTPRP-LSAEAFCPSP--VTPRF 2444

Query: 81   KKPPP-PEVTDLPKKPPPPEVTDLPKKPPPPEVT------------------DLPKKPSK 121
            + P P       P+   P      P +P PPEV                    LP  P+ 
Sbjct: 2445 QSPDPYSRPPSRPQSRDPFAPLHKPPRPQPPEVAFKAGSLAHTSLGAGGFPAALPAGPA- 2503

Query: 122  LELSDLSKKFPQ-----------LGA---TPFPRKPLQPE-VGEAPLKASLPEPGAPARK 166
                +L  K P             GA   TP P +   P+ VGE  LK  +P+PG P   
Sbjct: 2504 ---GELHAKVPSGQPPNFVRSPGTGAFVGTPSPMRFTFPQAVGEPSLKPPVPQPGLPPPH 2560

Query: 167  PL-----------QPDELS--------HPARPPSEPKSGAF----------PRKLWQPEA 197
             +           +P   +        HP+  P  P SG+           P  +  P A
Sbjct: 2561 GINSHFGPGPTLGKPQSTNYTVATGNFHPSGSPLGPSSGSTGESYGLSPLRPPSVLPPPA 2620

Query: 198  GEATPRSPQPELSTFPKKPAQPEFNVYPKKPPQPQVGG-LPKKSVP---QPEFSEAAQTP 253
                P    P LS    + +     V  ++ P   +G  L    +P    P  S  +QT 
Sbjct: 2621 ----PDGSLPYLSHGASQRSGITSPVEKREDPGTGMGSSLATAELPGTQDPGMSGLSQTE 2676

Query: 254  LWKPQSSE-----------------PKRDSSAFPKKASQPPLSDFPKKPPQPELGDLTR- 295
            L K +  +                  +++++A    A  PP S +  +P  P    L+R 
Sbjct: 2677 LEKQRQRQRLRELLIRQQIQRNTLRQEKETAAAAAGAVGPPGS-WGAEPSSPAFEQLSRG 2735

Query: 296  ------TSSEPEVSVLPKRPR------PAEFKA---LSKKPPQPELGGLPRTSSEPEFNS 340
                  T  +  +  LP          P  F +   LS+ PP       P T S  + NS
Sbjct: 2736 QTPFAGTQDKSSLVGLPPSKLSGPILGPGSFPSDDRLSRPPP-------PATPSSMDVNS 2788

Query: 341  LPRKLLQPERRGPPRKFSQ--PEPSAVLKRHPQPEF-------------FGDLPRKPPLP 385
              R+L+     G  + F Q  P P ++  +  Q +              F    R P  P
Sbjct: 2789 --RQLV-----GGSQAFYQRAPYPGSLPLQQQQQQLWQQQQATAATSMRFAMSARFPSTP 2841

Query: 386  S-SASESSLPAAVAGFSSRHPLSPGF---GAAGTPRWRS------GGLVHSGGARPGLRP 435
                   +L + +AG S+R P  PG    G AG  ++         GL   G   PG  P
Sbjct: 2842 GPELGRQALGSPLAGISTRLP-GPGEPVPGPAGPAQFIELRHNVQKGLGPGGTPFPGQGP 2900

Query: 436  SHPPRRRP------------LPPASSLGHPPAKPPLPPGP 463
               PR  P            L   +  G PP KP  PP P
Sbjct: 2901 PQRPRFYPVSEDPHRLAPEGLRGLAVSGLPPQKPSAPPAP 2940



 Score = 37.4 bits (85), Expect = 0.045
 Identities = 34/118 (28%), Positives = 47/118 (39%), Gaps = 17/118 (14%)

Query: 120  SKLELSDLSKKFPQLGATPFPRKPLQ-------PEVGEAPLKASLPEPGAPARKPLQPDE 172
            S+L++  L K+      +P P  P Q         +    L A  PE  +P   PL P  
Sbjct: 4871 SQLDILSLLKQ-----ESPAPEPPTQHSYTYNVSNLDVRQLSAPPPEEPSPPPSPLAPS- 4924

Query: 173  LSHPARPPSEPKSGAFPRKLWQPEAGEATPRSPQPELSTFPKKPAQPEFNVYPKKPPQ 230
               PA PP+EP        L +P      P +  PE S  PK  A+P       +PP+
Sbjct: 4925 ---PASPPTEPLVELPTEPLAEPPVPSPLPLASSPE-SARPKPRARPPEEGEDSRPPR 4978



 Score = 36.6 bits (83), Expect = 0.077
 Identities = 113/506 (22%), Positives = 173/506 (34%), Gaps = 93/506 (18%)

Query: 97   PPEVTDLPKKPPPPE--------VTDLPKKPSK-LELSDLSKKFPQLGATPFPRKPLQPE 147
            PPE+  +  K P P+        +T+      + L +S L K+  + G    P       
Sbjct: 1569 PPELVPMKVKEPEPQYFRFEGVWLTETGMALLRNLTMSPLHKRRQRRGRLGLP------- 1621

Query: 148  VGEAPLKASLPEPGAPARKPLQPDELSHPARPPSEPKSGAFPRKLWQPEAGEATPRSPQP 207
             GEA L+ S P         L PD+         E   G    +  + E     P SP  
Sbjct: 1622 -GEAGLEGSEPSDA------LGPDDKKDGDLDTDELLKGEGGVEHMECEIKLEGPVSPDV 1674

Query: 208  ELSTFPKKPAQPEFNVYPKKPPQPQVGGL---PKKSVPQPEFSEAAQTPLWKPQSSEPKR 264
            E    P K    E     +KP +P +GG     +KS  + +   AAQ  +        + 
Sbjct: 1675 E----PGKEETEESKKRKRKPYRPGIGGFMVRQRKSHTRTKKGPAAQAEVLSGDGQPDEV 1730

Query: 265  DSSAFPKK-ASQPPLSDFPKKPPQPELGDLTRTSSEPEVSVLPKRPRPAEFKALSKKP-- 321
              +  P + A +  L++  +K  Q   G       +   + L +     E   LS+K   
Sbjct: 1731 IPADLPAEGAVEQSLAEGDEKKKQQRRGRKKSKLEDMFPAYLQEAFFGKELLDLSRKALF 1790

Query: 322  ----PQPELG-GLPRTSSEPEFNSLPRKLLQPERRGPPRKFSQPEPSAVLKRH---PQPE 373
                 +P  G G P+   +       RK L   ++G        E S  L+     P PE
Sbjct: 1791 AVGVGRPSFGLGTPKAKGD---GGSERKELPTSQKGDDGPDIADEESRGLEGKADTPGPE 1847

Query: 374  FFG----DLPRKPPLPSSASESSLPAAVAGFSSRHPLSPGFGAAGTPRWRSGGLV----- 424
              G     +P  P  P +  E  L + +   S+             P+  S  L      
Sbjct: 1848 DGGVKASPVPSDPEKPGTPGEGMLSSDLDRISTEE----------LPKMESKDLQQLFKD 1897

Query: 425  --------HSGGARPGLRPSHPPRRRP-LPPASSLGHPPAKPPLPPGPVDMQSFRRPSAA 475
                    H G   PGL  S  P +RP L     LG+ P+  P       M S+  P   
Sbjct: 1898 VLGSEREQHLGCGTPGLEGSRTPLQRPFLQGGLPLGNLPSSSP-------MDSY--PGLC 1948

Query: 476  SIDLRRTRSAAGLHFQDRQPEDIPVPDEIYELYDDVEPRDDSSPSPKGRDEAPSVQQAAR 535
                  +R   G  F   +P +   PD  +       P   ++P+ +G  +  S  Q + 
Sbjct: 1949 QSPFLDSRERGG--FFSPEPGE---PDSPWTGSGGTTPSTPTTPTTEGEGDGLSYNQRSL 2003

Query: 536  RPPQDPALRKEKDPQPQQLPPMDPKL 561
            +       R EKD +  QL  + P L
Sbjct: 2004 Q-------RWEKDEELGQLSTISPVL 2022



 Score = 35.4 bits (80), Expect = 0.17
 Identities = 71/295 (24%), Positives = 100/295 (33%), Gaps = 56/295 (18%)

Query: 26   QPEPSDLPKKPPKP------------------EFGKLKKFSQPELSEHPKKAPLPEFGAV 67
            QP+PS L  +PP                      G+L   S  E S  P     P   +V
Sbjct: 4083 QPQPSSLQLQPPLRLPGQQQQQVSLLHTAGGGSHGQLGSGSSSEASSVPHLLAQP---SV 4139

Query: 68   SLKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPPP--------PEVTDLPKKP 119
            SL   P  +T     P  P +    ++P        P KP P        P V  +P   
Sbjct: 4140 SLGDQPGSMTQNLLGPQQPML----ERPMQNNTGPQPPKPGPVLQSGQGLPGVGIMPTVG 4195

Query: 120  S-KLELSDLSKKFPQLG-ATPFPRKPLQPEVGEAPLKASLPEPGAPARKPLQPDELSHPA 177
              + +L  +  K PQL   +P  ++ LQ  + +  L+ S      P  +  +P   + P 
Sbjct: 4196 QLRAQLQGVLAKNPQLRHLSPQQQQQLQALLMQRQLQQSQAVRQTPPYQ--EPGTQTSPL 4253

Query: 178  RP--PSEPKSGAFPRKLWQPEAGEATPRSPQPELSTFPKKPAQPEFNVYPKKPPQPQVGG 235
            +     +P+ G FP     P+ G      P  EL   P+    P     P       V G
Sbjct: 4254 QGLLGCQPQLGGFPG----PQTG------PLQELGAGPRPQGPPRLPAPPGALSTGPVLG 4303

Query: 236  LPKKSVPQPEFSEAAQTPLWKPQSSEPKRDSSAFPKKASQPPLSDFPKKPPQPEL 290
             P    P P   +  + P   P  S      S  P +A  PP      KP  P L
Sbjct: 4304 -PVHPTPPPSSPQEPKRPSQLPSPS------SQLPTEAQLPPTHPGTPKPQGPTL 4351



 Score = 33.9 bits (76), Expect = 0.50
 Identities = 78/318 (24%), Positives = 111/318 (34%), Gaps = 44/318 (13%)

Query: 27   PEPSDLPKKPPKP-EFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPPPEVTDLPKKPPP 85
            P P +    P  P +F +L+   Q  L   P   P P  G    +P    V++ P +  P
Sbjct: 2862 PGPGEPVPGPAGPAQFIELRHNVQKGLG--PGGTPFPGQGPPQ-RPRFYPVSEDPHRLAP 2918

Query: 86   PEVTDL------PKKPPPPEVTDLPKKPPPPEVTDLPKKPSKLELSDLSKKFPQLGATPF 139
              +  L      P+KP  P   +L     P   T  P  P+ LEL +      +LG    
Sbjct: 2919 EGLRGLAVSGLPPQKPSAPPAPELNNSLHPTPHTKGPTLPTGLELVNRPPSSTELGRP-- 2976

Query: 140  PRKPLQPEVGEAPLKASLPEPGAPARKPLQPD-ELSHPARPPSEPKSGAFPRKLWQPEAG 198
               PL  E G+ P +    +    A K L+ D EL+H        K       L   E  
Sbjct: 2977 --NPLALEAGKLPCEDPELDDDFDAHKALEDDEELAHLGLGVDVAKGDDELGTLENLETN 3034

Query: 199  EATPRSPQPELSTFPKKPAQPEFNVYPKKPPQPQVGGLPKKSVPQPEFSEAAQTPLWKPQ 258
            +       P L          EF++     P+   G   KK +    F+E     L   +
Sbjct: 3035 D-------PHLDDLLN---GDEFDLLAYTDPELDTG--DKKDI----FNE----HLRLVE 3074

Query: 259  SSEPKRDSSAFPKKASQPPLSDFPKKPPQPELGDLTRTSSEPEVSVLPK------RPRPA 312
            S+  K +  A  +     PL    + PP  +  +    S  PEV   PK       P P 
Sbjct: 3075 SANEKAEREALLRGVEPGPLGPEERPPPAADASEPRLASVLPEVK--PKVEEGGRHPSPC 3132

Query: 313  EFK-ALSKKPPQPELGGL 329
            +F  A  K  P P    L
Sbjct: 3133 QFTIATPKVEPAPAANSL 3150



 Score = 33.1 bits (74), Expect = 0.85
 Identities = 53/233 (22%), Positives = 77/233 (33%), Gaps = 39/233 (16%)

Query: 346 LQPERRGPPRKFSQPEPSAVLKRHPQPEFFGDLPRKPPLPSSASESSLPAAVAGFSSRHP 405
           +QP+  GP +  ++P   A ++  PQ E    L  + PL     ES L           P
Sbjct: 404 MQPKEPGPLQCEAKPLGKAGVQLEPQLE--APLNEEMPLLPPPEESPLSPP----PEESP 457

Query: 406 LSPGFGAAGTPRWRSGGLVHSGGARPGLRPSHPPRR---RPLPPASSLGHPPAKPPLPPG 462
            SP   A+                    R S PP      PLP A  L  P  + PL P 
Sbjct: 458 TSPPPEAS--------------------RLSPPPEELPASPLPEALHLSRPLEESPLSPP 497

Query: 463 PVDMQSFRRPSAASIDLRRTRSAAGLHFQDRQPEDIPVPDEIYELYDDVEPRDDSSPSPK 522
           P +      P ++          +        PE+ P P    E    + P  ++SP   
Sbjct: 498 PEESPLSPPPESSPFSPLEESPLS-------PPEESP-PSPALET--PLSPPPEASPLSP 547

Query: 523 GRDEAPSVQQAARRPPQDPALRKEKDPQPQQLPPMDPKLLKQLRKAEKAEREF 575
             +E+P        P   P       P P++ P   P     +    +A R F
Sbjct: 548 PFEESPLSPPPEELPTSPPPEASRLSPPPEESPMSPPPEESPMSPPPEASRLF 600



 Score = 33.1 bits (74), Expect = 0.85
 Identities = 18/50 (36%), Positives = 23/50 (46%), Gaps = 6/50 (12%)

Query: 69   LKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKP--PPPEVTDLP 116
            L  PPPE       PPP  +   P  PP   + +LP +P   PP  + LP
Sbjct: 4906 LSAPPPE----EPSPPPSPLAPSPASPPTEPLVELPTEPLAEPPVPSPLP 4951



 Score = 32.7 bits (73), Expect = 1.1
 Identities = 30/97 (30%), Positives = 37/97 (38%), Gaps = 28/97 (28%)

Query: 84   PPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPSKLELSDLSKKFPQLGATPFPRKP 143
            PPPE       PPP  +   P  PP   + +LP +P              L   P P  P
Sbjct: 4909 PPPE----EPSPPPSPLAPSPASPPTEPLVELPTEP--------------LAEPPVP-SP 4949

Query: 144  LQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARPP 180
            L       PL AS PE   P  +   P+E    +RPP
Sbjct: 4950 L-------PL-ASSPESARPKPRARPPEE-GEDSRPP 4977



 Score = 32.3 bits (72), Expect = 1.5
 Identities = 26/87 (29%), Positives = 34/87 (39%), Gaps = 9/87 (10%)

Query: 11   SHQDFRSIKAKF-QASQPEPSDLPKKPPKPEFGKLKKFSQPELSEHPKKAPLPEFGAVSL 69
            S+ D R + A   +   P PS L   P  P    L +     L+E P  +PLP      L
Sbjct: 4899 SNLDVRQLSAPPPEEPSPPPSPLAPSPASPPTEPLVELPTEPLAEPPVPSPLP------L 4952

Query: 70   KPPPPEVTDLPKKPPPPEVTDLPKKPP 96
               P      P+  PP E  D   +PP
Sbjct: 4953 ASSPESARPKPRARPPEEGED--SRPP 4977



 Score = 32.0 bits (71), Expect = 1.9
 Identities = 73/314 (23%), Positives = 108/314 (34%), Gaps = 59/314 (18%)

Query: 181  SEPKSGAFPRKLWQPEAGEATPRSPQPELSTFPKKPA--QPEFNVYPKKPPQP----QVG 234
            S  ++ + P  L QP            +    P++P   +P  N    +PP+P    Q G
Sbjct: 4123 SSSEASSVPHLLAQPSVSLGDQPGSMTQNLLGPQQPMLERPMQNNTGPQPPKPGPVLQSG 4182

Query: 235  -GLPKKSVPQPEFSEA--------AQTPLWKPQSSEPKRDSSAFPKKASQPPLSDFPKKP 285
             GLP   +  P   +         A+ P  +  S + ++   A   +          + P
Sbjct: 4183 QGLPGVGI-MPTVGQLRAQLQGVLAKNPQLRHLSPQQQQQLQALLMQRQLQQSQAVRQTP 4241

Query: 286  PQPELGDLTRTSSEPEVSVLPKRPRPAEFKALSKKPPQPELGGLPRTSSEPEFNSLPRKL 345
            P  E G    T + P   +L  +P+   F      P Q ELG  PR              
Sbjct: 4242 PYQEPG----TQTSPLQGLLGCQPQLGGFPGPQTGPLQ-ELGAGPRP------------- 4283

Query: 346  LQPERRGPPRKFSQPEPSAVLKRHPQPEFFGDLPRKPPLPSSASESSLPAAVAGFSSRHP 405
                 +GPPR    P P   L   P     G +   PP PSS  E   P+ +   SS+ P
Sbjct: 4284 -----QGPPR---LPAPPGALSTGP---VLGPVHPTPP-PSSPQEPKRPSQLPSPSSQLP 4331

Query: 406  LSPGFGAAGTPRWRSGGLVHSGGARPGLRPSHPPRRRPLPPASSLGHPPAKPPLPP--GP 463
                   A  P        H G  +P      PP  R  P A+ L        L P   P
Sbjct: 4332 TE-----AQLPP------THPGTPKPQGPTLEPPPGRVSPAAAQLADTLFSKGLGPWDPP 4380

Query: 464  VDMQSFRRPSAASI 477
             ++   ++P  +S+
Sbjct: 4381 DNLAETQKPEQSSL 4394



 Score = 30.8 bits (68), Expect = 4.2
 Identities = 48/190 (25%), Positives = 64/190 (33%), Gaps = 47/190 (24%)

Query: 127  LSKKFPQLGATPFPRKPL----QPEVGEAP--------LKASLPEPGAPARKPL------ 168
            LS K P      FP  P     +P+ GEA         L+   P+ G    K        
Sbjct: 4807 LSMKIPNSYEVLFPESPARAGTEPKKGEAEGPGGKEKGLEGKSPDTGPDWLKQFDAVLPG 4866

Query: 169  -----QPDELS-----HPA-RPPSEPKSGAFPRKLWQPEAGEATPRSPQPELSTFPKKPA 217
                 Q D LS      PA  PP++         L   +     P  P P  S     PA
Sbjct: 4867 YTLKSQLDILSLLKQESPAPEPPTQHSYTYNVSNLDVRQLSAPPPEEPSPPPSPLAPSPA 4926

Query: 218  QPEFNVYPKKPPQPQVGGLPKKSVPQPEFSEAAQTPLWKPQSSEPKRDSSAFPKKASQPP 277
             P      + P +P    L +  VP P            P +S P+   SA PK  ++PP
Sbjct: 4927 SPPTEPLVELPTEP----LAEPPVPSP-----------LPLASSPE---SARPKPRARPP 4968

Query: 278  LSDFPKKPPQ 287
                  +PP+
Sbjct: 4969 EEGEDSRPPR 4978



 Score = 30.0 bits (66), Expect = 7.2
 Identities = 13/26 (50%), Positives = 13/26 (50%)

Query: 436  SHPPRRRPLPPASSLGHPPAKPPLPP 461
            S PP   P PP S L   PA PP  P
Sbjct: 4907 SAPPPEEPSPPPSPLAPSPASPPTEP 4932



 Score = 29.6 bits (65), Expect = 9.4
 Identities = 26/101 (25%), Positives = 37/101 (36%), Gaps = 20/101 (19%)

Query: 37   PKPEFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPPPEVTDLPKKPPPPEVTDLPKK-- 94
            P+P       ++   L      AP PE       PPP  +   P  PP   + +LP +  
Sbjct: 4886 PEPPTQHSYTYNVSNLDVRQLSAPPPE----EPSPPPSPLAPSPASPPTEPLVELPTEPL 4941

Query: 95   --PPPPEVTDL----------PKKPPPPEVTDLPKKPSKLE 123
              PP P    L          P+  PP E  D   +P +L+
Sbjct: 4942 AEPPVPSPLPLASSPESARPKPRARPPEEGED--SRPPRLK 4980


>gi|110349719 titin isoform N2-A [Homo sapiens]
          Length = 33423

 Score =  111 bits (277), Expect = 2e-24
 Identities = 151/570 (26%), Positives = 218/570 (38%), Gaps = 132/570 (23%)

Query: 22    FQASQPEPSDLPKKPPKPEFGKLKKFSQPELSEH---PKKAPLPEFGAVSLKPPPPEVTD 78
             F+A + E  + PK PPK           PE+SE    PKK P      V  K PP +V +
Sbjct: 10425 FEAEEVEVFEKPKAPPKG----------PEISEKIIPPKKPPTK---VVPRKEPPAKVPE 10471

Query: 79    LPKKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPSKLELSDLSKKFPQLGATP 138
             +PKK    E   +P++P  P  T +P+  PP EV    K P                  P
Sbjct: 10472 VPKKIVVEEKVRVPEEPRVPP-TKVPEVLPPKEVVPEKKVP-----------------VP 10513

Query: 139   FPRKPLQP--EVGEAPLKASLPEPGAPARKPLQPDELSHPARPPSEPKSGAFPRKLWQPE 196
               +KP  P  +V EAP K  +PE   P   P +P+    P + P  PK+    +K+  PE
Sbjct: 10514 PAKKPEAPPPKVPEAP-KEVVPEKKVPVPPPKKPEV--PPTKVPEVPKAAVPEKKV--PE 10568

Query: 197   AGEATPRSPQPELSTFPKKPAQPEFNVYPKKPPQPQVGGLPKKSVPQPEFSEAAQTPLWK 256
             A    P SP PE+   PK+   PE  V    P +P+V  +     P+    E        
Sbjct: 10569 AIPPKPESPPPEVPEAPKEVV-PEKKVPAAPPKKPEVTPVKVPEAPKEVVPE-------- 10619

Query: 257   PQSSEPKRDSSAFPKKASQPPLSDFPKKPPQPELGDLTRTSSEPEVSVLPKRPRPAEFKA 316
                           KK   PP    PKKP  P     T+    P+V+V P++  P   +A
Sbjct: 10620 --------------KKVPVPP----PKKPEVPP----TKVPEVPKVAV-PEKKVP---EA 10653

Query: 317   LSKKPPQPELGGLPRTSSEPEFNSLPRKLLQPERRGPPRKFSQPEPSAVLKRHPQPEFFG 376
             +  KP  P     P    EPE  +L           P     +PEP+A     PQ     
Sbjct: 10654 IPPKPESPP----PEVFEEPEEVALEEP--------PAEVVEEPEPAAP----PQVT--- 10694

Query: 377   DLPRKPPLPSSASESSLPAAVAGFSSRHPLS-PGFGAAGTPRWRSGGLVHSGGARPGLRP 435
              +P K P+P    E   PA VA      P+  P       P  +   +V         +P
Sbjct: 10695 -VPPKKPVP----EKKAPAVVAKKPELPPVKVPEVPKEVVPEKKVPLVVPK-------KP 10742

Query: 436   SHPPRRRPLPPASSLGHP----PAKPPLPPGPVDMQSFRRPSAASIDLRRTRSAAGLHFQ 491
               PP + P  P   +       P KP +PP  V       P      +   + A  +  +
Sbjct: 10743 EAPPAKVPEVPKEVVPEKKVAVPKKPEVPPAKV-------PEVPKKPVLEEKPAVPVPER 10795

Query: 492   DRQPEDIPVPDEIYELYDDVEPRDDSSPS-----PKGRDEAPSVQQAARRPPQDPALRKE 546
                P     P E+YE  +++ P ++ +P      P   +E P V   A        + ++
Sbjct: 10796 AESP-----PPEVYEEPEEIAPEEEIAPEEEKPVPVAEEEEPEVPPPAVPEEPKKIIPEK 10850

Query: 547   KDP---QPQQLPPMDPKLLKQLRKAEKAER 573
             K P   +P+  PP +P+  K + K +   R
Sbjct: 10851 KVPVIKKPEAPPPKEPEPEKVIEKPKLKPR 10880



 Score = 95.5 bits (236), Expect = 1e-19
 Identities = 142/571 (24%), Positives = 217/571 (38%), Gaps = 125/571 (21%)

Query: 36    PPKPEFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPPPEVTDLPKKPPPPEVTDLPKKP 95
             PPKPE    + F +PE               V+L+ PP EV + P+   PP+VT  PKKP
Sbjct: 10655 PPKPESPPPEVFEEPE--------------EVALEEPPAEVVEEPEPAAPPQVTVPPKKP 10700

Query: 96    PPPEVTD--LPKKP--PPPEVTDLPKKPSKLELSDLSKKFPQLGATPFPRKPLQP--EVG 149
              P +     + KKP  PP +V ++PK+          KK P +     P+KP  P  +V 
Sbjct: 10701 VPEKKAPAVVAKKPELPPVKVPEVPKEVVP------EKKVPLV----VPKKPEAPPAKVP 10750

Query: 150   EAPLKASLPEPGAPARKPLQPDELSHPARPPSEPKSGAFPRK--LWQPEAGEATPR---- 203
             E P +    +  A  +KP  P     PA+ P  PK      K  +  PE  E+ P     
Sbjct: 10751 EVPKEVVPEKKVAVPKKPEVP-----PAKVPEVPKKPVLEEKPAVPVPERAESPPPEVYE 10805

Query: 204   -----SPQPELSTFPKKPAQPEFNVYPKKPPQPQVGGLPKKSVPQPEFSEAAQTPLWKPQ 258
                  +P+ E++   +KP        P+ PP P V   PKK +P+ +     +     P+
Sbjct: 10806 EPEEIAPEEEIAPEEEKPVPVAEEEEPEVPP-PAVPEEPKKIIPEKKVPVIKKPEAPPPK 10864

Query: 259   SSEPKRDSSAFPKKASQPPLSDFPKKPPQPELGDLTRTSSEPEVSVLPKRPRPAEFKALS 318
               EP++     PK   +P     P  PP P   D+       ++  +PK+  P       
Sbjct: 10865 EPEPEKVIEK-PKLKPRP-----PPPPPAPPKEDVKEKIF--QLKAIPKKKVP------- 10909

Query: 319   KKPPQPELGGLPRTSSEPEFNSLPRKLLQPERRGPPRKFSQPEPSAVLKRHPQPEFFGDL 378
             +KP  PE   L      P      RKLL PER+  P++  +    +VL++ P+ E     
Sbjct: 10910 EKPQVPEKVEL-TPLKVPGGEKKVRKLL-PERKPEPKE--EVVLKSVLRKRPEEEEPKVE 10965

Query: 379   PRK-----------PPLPSSASESSLPAAVAGFSSRHPLSPGFGAAGTPRWRSGGLVHSG 427
             P+K           PP P    E  +P                    T R R    +   
Sbjct: 10966 PKKLEKVKKPAVPEPPPPKPVEEVEVPTV------------------TKRERK---IPEP 11004

Query: 428   GARPGLRPSHP---PRRRPLPPASSLGHPPAKPPLPPGPVDMQSFRRPSAASIDLRRTRS 484
                P ++P+ P   P  +P P A      P  PP+ P P        P AA +    T  
Sbjct: 11005 TKVPEIKPAIPLPAPEPKPKPEAEVKTIKP--PPVEPEPT-------PIAAPV----TVP 11051

Query: 485   AAGLHFQDRQPEDIPVPDEIYELYDDVEPRDDSSPSPKGRDEAPSVQQAARRPPQDPALR 544
               G   + + P++           +  +P+      PK        ++   RP       
Sbjct: 11052 VVGKKAEAKAPKE-----------EAAKPKGPIKGVPKKTPSPIEAERRKLRPGSGGEKP 11100

Query: 545   KEKDPQPQQLPPMDPKLLKQLRKAEKAEREF 575
              ++ P   QL  +  K +K+++     E EF
Sbjct: 11101 PDEAPFTYQLKAVPLKFVKEIKDIILTESEF 11131



 Score = 80.5 bits (197), Expect = 5e-15
 Identities = 68/203 (33%), Positives = 90/203 (44%), Gaps = 42/203 (20%)

Query: 72   PPPEVTDLPKKPPPPEV--TDLPKK--PPPPEVTDLPKKPPPPEVTDLPKKPSKLELSDL 127
            PPP+V +LP+KP P EV    +PKK  PP P+V ++PKKP P E     KKP        
Sbjct: 9284 PPPKVPELPEKPAPEEVAPVPIPKKVEPPAPKVPEVPKKPVPEE-----KKP-------- 9330

Query: 128  SKKFPQLGATPFPRK--PLQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARPPSEPKS 185
                      P P+K     P+V E P K  +PE   P   P+   + + PA+ P   K 
Sbjct: 9331 ---------VPVPKKEPAAPPKVPEVP-KKPVPEEKIPV--PVAKKKEAPPAKVPEVQKG 9378

Query: 186  GAFPRKLWQPEAGEATPRSPQPELSTFPKKPAQPEFNVYPKK----PPQPQVGGLPKKSV 241
                 K+      E    SP P +   PKK    E    P+K    PP P+V  LPKK V
Sbjct: 9379 VVTEEKITIVTQRE---ESPPPAVPEIPKKKVPEERKPVPRKEEEVPPPPKVPALPKKPV 9435

Query: 242  PQPEFSEAAQTPLWKPQSSEPKR 264
            P+    E    P+   + + P R
Sbjct: 9436 PE----EKVAVPVPVAKKAPPPR 9454



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 119/506 (23%), Positives = 186/506 (36%), Gaps = 83/506 (16%)

Query: 29    PSDLPKKPPKPEFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPPPEVTDLPK--KPPPP 86
             P  +P+ P KP   + K    P+  E P  A +PE   V  KP       +PK  KPPP 
Sbjct: 9947  PVKVPEVPRKPVPEEKKPVPVPKKKEAPP-AKVPE---VPKKPEEKVPVLIPKKEKPPPA 10002

Query: 87    EVTDLPKKPPPPEVTDLP----KKPPPPEVTDLPKKPSKLELSDLSKKFPQLGATPFPRK 142
             +V ++PKKP P E   +P     + PP +V ++PKKP         KK P     P P+K
Sbjct: 10003 KVPEVPKKPVPEEKVPVPVPKKVEAPPAKVPEVPKKPVP------EKKVP----VPAPKK 10052

Query: 143   PLQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARPPSEPKSGAFPRKLWQPEAGEATP 202
                    EAP          PA+ P  P +L      P E K    P+K+  P       
Sbjct: 10053 V------EAP----------PAKVPEVPKKLI-----PEEKKPTPVPKKVEAPPPKVPKK 10091

Query: 203   RSPQPELSTFPKKPAQPEFNVYPKKPPQPQVGGLPKKSVPQPEFSEAAQTPLWKPQSSEP 262
             R P P     P+     E  V  ++   P+   LP++    PE  E        P+  E 
Sbjct: 10092 REPVPVPVALPQ-----EEEVLFEEEIVPEEEVLPEEEEVLPEEEEVL------PEEEEV 10140

Query: 263   KRDSSAFPKKASQPPLSDFPKKPPQPELGDLTRTSSEPEVSVLPKRPRPAEFKALSKKPP 322
               +    P +  + P    P++   PE  +      E    V PK P PA    + KK  
Sbjct: 10141 LPEEEEIPPEEEEVP----PEEEYVPEEEEFV-PEEEVLPEVKPKVPVPAPVPEIKKKVT 10195

Query: 323   QPELGGLPRTSSEPEFNSLPRKLLQPERRGPPRKFSQPEPSAVL------KRHPQPEFFG 376
             + ++  +P+    P     P K+ +  ++   ++   P+   VL      +   +P    
Sbjct: 10196 EKKV-VIPKKEEAP-----PAKVPEVPKKVEEKRIILPKEEEVLPVEVTEEPEEEPISEE 10249

Query: 377   DLPRKPPLPSSASESSLPAAVAGFSSRHPLSPGFGAAGTPRWRSGGLVHSGGARPGLRPS 436
             ++P +PP      E + P          P +P       P+             P  +  
Sbjct: 10250 EIPEEPPSIEEVEEVAPPRVPEVIKKAVPEAP----TPVPKKVEAPPAKVSKKIPEEKVP 10305

Query: 437   HPPRRRPLPPASSLGHP----------PAKPPLPPGPVDMQSFRRPSAASIDLRRTRSAA 486
              P +++  PPA     P          P K  +PP         + S A       +   
Sbjct: 10306 VPVQKKEAPPAKVPEVPKKVPEKKVLVPKKEAVPPAKGRTVLEEKVSVAFRQEVVVKERL 10365

Query: 487   GLHFQDRQPEDIPVPDEIYELYDDVE 512
              L   + + E+IP  +E +E+ +  E
Sbjct: 10366 ELEVVEAEVEEIPEEEEFHEVEEYFE 10391



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 91/333 (27%), Positives = 125/333 (37%), Gaps = 58/333 (17%)

Query: 29    PSDLPKKPPKPEFGKLKKFSQPELSEHPKK---------APLPEFGAVSLKP-------- 71
             P+ +P+ P KP   +      PE +E P           AP  E      KP        
Sbjct: 10772 PAKVPEVPKKPVLEEKPAVPVPERAESPPPEVYEEPEEIAPEEEIAPEEEKPVPVAEEEE 10831

Query: 72    ---PPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPK-------KPSK 121
                PPP V + PKK  P +   + KKP  P     PK+P P +V + PK        P  
Sbjct: 10832 PEVPPPAVPEEPKKIIPEKKVPVIKKPEAPP----PKEPEPEKVIEKPKLKPRPPPPPPA 10887

Query: 122   LELSDLSKKFPQLGATPFPRKPLQPEVGEAPLKASLPEPGA--PARKPLQPDELSHPARP 179
                 D+ +K  QL A P  + P +P+V E      L  PG     RK L       P R 
Sbjct: 10888 PPKEDVKEKIFQLKAIPKKKVPEKPQVPEKVELTPLKVPGGEKKVRKLL-------PERK 10940

Query: 180   PSEPKSGAFPRKLWQPEAGEATPRSPQPELSTFPKKPAQPEFNVYPKKPPQPQVGGLPKK 239
             P EPK     + + +    E  P+  +P+     KKPA PE    P  P   +   +P  
Sbjct: 10941 P-EPKEEVVLKSVLRKRPEEEEPK-VEPKKLEKVKKPAVPE----PPPPKPVEEVEVPTV 10994

Query: 240   SVPQPEFSEAAQTPLWKP----QSSEPKRDSSAFPKKASQPPLSDFP----KKPPQPELG 291
             +  + +  E  + P  KP     + EPK    A  K    PP+   P         P +G
Sbjct: 10995 TKRERKIPEPTKVPEIKPAIPLPAPEPKPKPEAEVKTIKPPPVEPEPTPIAAPVTVPVVG 11054

Query: 292   DLTRTSSEPEVSVLPKRPRPAEFKALSKKPPQP 324
                   +  E +  PK P     K + KK P P
Sbjct: 11055 KKAEAKAPKEEAAKPKGP----IKGVPKKTPSP 11083



 Score = 73.2 bits (178), Expect = 7e-13
 Identities = 106/389 (27%), Positives = 157/389 (40%), Gaps = 82/389 (21%)

Query: 50   PELSEHP---KKAPLPEFGAVSLKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKK 106
            PEL E P   + AP+P      ++PP P+V ++PKKP P E     KKP P     +PKK
Sbjct: 9289 PELPEKPAPEEVAPVPI--PKKVEPPAPKVPEVPKKPVPEE-----KKPVP-----VPKK 9336

Query: 107  PP--PPEVTDLPKKPSKLELSDLSKKFPQLGATPFPRKPLQPEVGEAPLKASLPEPGAPA 164
             P  PP+V ++PKKP   E      K P     P  +K   P     P K    + G   
Sbjct: 9337 EPAAPPKVPEVPKKPVPEE------KIP----VPVAKKKEAP-----PAKVPEVQKGVVT 9381

Query: 165  RKPLQPDELSHPARPPSEPKSGAFPRKLWQPEAGEATPRS-----PQPELSTFPKKPAQP 219
             + +        + PP+ P+    P+K   PE  +  PR      P P++   PKKP   
Sbjct: 9382 EEKITIVTQREESPPPAVPE---IPKKK-VPEERKPVPRKEEEVPPPPKVPALPKKPVPE 9437

Query: 220  EFNVYP----KKPPQPQVGGLPKKSVPQPEFSEAAQTPLWKPQSSEPKR------DSSAF 269
            E    P    KK P P+     K  V +  F    +     PQ  E  R      +  ++
Sbjct: 9438 EKVAVPVPVAKKAPPPRAEVSKKTVVEEKRFVAEEKLSFAVPQRVEVTRHEVSAEEEWSY 9497

Query: 270  PKKASQPPLSDF-PKKPPQPELGDLT--RTSSEPEVSVLPKR---------PRPAEF--- 314
             ++     +S +  ++  + E  ++T      EPE  V+ ++           PAE    
Sbjct: 9498 SEEEEGVSISVYREEEREEEEEAEVTEYEVMEEPEEYVVEEKLHIISKRVEAEPAEVTER 9557

Query: 315  --KALSKKPPQPELGGLPRTSSEPEFNSLPRKLLQPERRGP---PRKFSQPEPSAVLK-R 368
              K +  KP  P     P  +  PE    P+K++ PE++ P   P+K   P P    + +
Sbjct: 9558 QEKKIVLKPKIPAKIEEPPPAKVPE---APKKIV-PEKKVPAPVPKKEKVPPPKVPEEPK 9613

Query: 369  HPQPEFFGDLPRKPPLPSSASESSLPAAV 397
             P PE      +K P      E  LPA V
Sbjct: 9614 KPVPE------KKVPPKVIKMEEPLPAKV 9636



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 108/444 (24%), Positives = 164/444 (36%), Gaps = 97/444 (21%)

Query: 10    ESHQDFRSIKAKFQASQPEPSD-LPKKPPKPEFGKLKKFSQPELSEHPKKAPLPEFGAVS 68
             E H+++ +   K    +P P + +P KP  P    LKK     + E     P+P+     
Sbjct: 9780  EEHEEYITEPEKPIPVKPVPEEPVPTKPKAPPAKVLKK----AVPEEKVPVPIPK----K 9831

Query: 69    LKPPPPEVTDLPKK-------------------PPPPEVTDLPKKPPPPEVTDLPKKPPP 109
             LKPPPP+V + PKK                    P  +V   PK+    E   +P+K   
Sbjct: 9832  LKPPPPKVPEEPKKVFEEKIRISITKREKEQVTEPAAKVPMKPKRVVAEEKVPVPRKEVA 9891

Query: 110   PEVTDLPKKPSKLELSDLSKKFPQLGAT-------------------------PFPRKPL 144
             P V  +P+ P +LE  +++  F +   T                           P  P+
Sbjct: 9892  PPVR-VPEVPKELEPEEVA--FEEEVVTHVEEYLVEEEEEYIHEEEEFITEEEVVPVIPV 9948

Query: 145   Q-PEVGEAPLKASLPEPGAPARKPLQPDELSHPARPPSEPKSGAFPRKLWQPEAG-EATP 202
             + PEV   P+         P +K   P ++    + P E      P+K   P A     P
Sbjct: 9949  KVPEVPRKPVPEEKKPVPVPKKKEAPPAKVPEVPKKPEEKVPVLIPKKEKPPPAKVPEVP 10008

Query: 203   RSPQPELST---FPKKPAQPEFNVYPKKPPQPQVGGLPKKSVPQPEFSEAAQTPLWKPQS 259
             + P PE       PKK   P   V P+ P +P    +P+K VP P   +    P   P+ 
Sbjct: 10009 KKPVPEEKVPVPVPKKVEAPPAKV-PEVPKKP----VPEKKVPVPAPKKVEAPPAKVPEV 10063

Query: 260   SE----PKRDSSAFPKKASQPPLSDFPKKPPQP-------ELGDLTRTSSEPEVSVLPKR 308
              +     ++  +  PKK   PP     K+ P P       E   L      PE  VLP+ 
Sbjct: 10064 PKKLIPEEKKPTPVPKKVEAPPPKVPKKREPVPVPVALPQEEEVLFEEEIVPEEEVLPEE 10123

Query: 309   PR--PAEFKALSKKPPQPELGGLPRTSSEPEFNSLPRKLLQPERRGPPRKFSQPEPSAVL 366
                 P E + L   P + E+         PE   +P +    E   PP +   PE    +
Sbjct: 10124 EEVLPEEEEVL---PEEEEV--------LPEEEEIPPE----EEEVPPEEEYVPEEEEFV 10168

Query: 367   KRHPQPEFFGDLPRKPPLPSSASE 390
                P+ E   ++  K P+P+   E
Sbjct: 10169 ---PEEEVLPEVKPKVPVPAPVPE 10189



 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 153/697 (21%), Positives = 241/697 (34%), Gaps = 173/697 (24%)

Query: 29    PSDLPKKPPKPE------FGKLKKFSQPELSEHPKKAPLPEFGAV-----SLKPPPPEVT 77
             P+ +P+ P KPE        K +K    ++ E PKK P+PE          ++ PP +V 
Sbjct: 9975  PAKVPEVPKKPEEKVPVLIPKKEKPPPAKVPEVPKK-PVPEEKVPVPVPKKVEAPPAKVP 10033

Query: 78    DLPKKPPPPEVTDLPK----KPPPPEVTDLPKKPPPPEV--TDLPKK--------PSKLE 123
             ++PKKP P +   +P     + PP +V ++PKK  P E   T +PKK        P K E
Sbjct: 10034 EVPKKPVPEKKVPVPAPKKVEAPPAKVPEVPKKLIPEEKKPTPVPKKVEAPPPKVPKKRE 10093

Query: 124   LSDLSKKFPQLGATPF-----PRKPLQPEVGEAPLKAS--LPEPGA--PARKPLQPDELS 174
                +    PQ     F     P + + PE  E   +    LPE     P  + + P+E  
Sbjct: 10094 PVPVPVALPQEEEVLFEEEIVPEEEVLPEEEEVLPEEEEVLPEEEEVLPEEEEIPPEEEE 10153

Query: 175   HPARPPSEPKSGAF-PRKLWQPEAGEATP-RSPQPELS--------TFPKKPAQPEFNV- 223
              P      P+   F P +   PE     P  +P PE+           PKK   P   V 
Sbjct: 10154 VPPEEEYVPEEEEFVPEEEVLPEVKPKVPVPAPVPEIKKKVTEKKVVIPKKEEAPPAKVP 10213

Query: 224   -------------------------------------YPKKPPQ---------PQVGGLP 237
                                                   P++PP          P+V  + 
Sbjct: 10214 EVPKKVEEKRIILPKEEEVLPVEVTEEPEEEPISEEEIPEEPPSIEEVEEVAPPRVPEVI 10273

Query: 238   KKSVPQPEFSEAAQTPLWKPQSSEPKRDSSAFPK--------KASQPP--LSDFPKKPPQ 287
             KK+VP+      A TP+ K   + P + S   P+        K   PP  + + PKK P+
Sbjct: 10274 KKAVPE------APTPVPKKVEAPPAKVSKKIPEEKVPVPVQKKEAPPAKVPEVPKKVPE 10327

Query: 288   PEL---------GDLTRTSSEPEVSVLPKRPRPAEFKA--------LSKKPPQPELGGLP 330
              ++             RT  E +VSV  ++    + +         + + P + E   + 
Sbjct: 10328 KKVLVPKKEAVPPAKGRTVLEEKVSVAFRQEVVVKERLELEVVEAEVEEIPEEEEFHEVE 10387

Query: 331   RTSSEPEFNSLPRKLLQPERRGPPRKFSQPEPSAVLKRHPQPEFFG-------DLPRKPP 383
                 E EF+ +   +   + R         E   V K H   E F        + P+ PP
Sbjct: 10388 EYFEEGEFHEVEEFIKLEQHR-------VEEEHRVEKVHRVIEVFEAEEVEVFEKPKAPP 10440

Query: 384   LPSSASESSLPAAVAGFSSRHPLSPGFGAAGTPRWRSGGLVHSGGARPGLRPSHPP---- 439
                  SE  +P             P       P+     +V     R    P  PP    
Sbjct: 10441 KGPEISEKIIPPKKPPTKVVPRKEPPAKVPEVPK----KIVVEEKVRVPEEPRVPPTKVP 10496

Query: 440   -----------RRRPLPPASSLGHPPAKPP------LPPGPVDMQSFRRPSAASIDLRRT 482
                        ++ P+PPA     PP K P      +P   V +   ++P      +   
Sbjct: 10497 EVLPPKEVVPEKKVPVPPAKKPEAPPPKVPEAPKEVVPEKKVPVPPPKKPEVPPTKVPEV 10556

Query: 483   RSAAGLHFQDRQPEDIP-----VPDEIYELYDDVEPRDDSSPSPKGRDEAPSVQQAARRP 537
               AA    + + PE IP      P E+ E   +V P      +P  + E   V+      
Sbjct: 10557 PKAAVP--EKKVPEAIPPKPESPPPEVPEAPKEVVPEKKVPAAPPKKPEVTPVK--VPEA 10612

Query: 538   PQDPALRKEKDPQPQQLPPMDPKLLKQLRKAEKAERE 574
             P++    K+    P + P + P  + ++ K    E++
Sbjct: 10613 PKEVVPEKKVPVPPPKKPEVPPTKVPEVPKVAVPEKK 10649



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 72/305 (23%), Positives = 116/305 (38%), Gaps = 58/305 (19%)

Query: 93   KKPPPPEVTDLPKKPPPPEVTDLPKKPSKLELSDLS-KKFPQLGATPFPRKPLQPEVGEA 151
            KK PPP     PK    P +  + K   ++E   +   K P++     P+KP +  V E 
Sbjct: 9172 KKAPPP-----PKVIKKPVIEKIEKTSRRMEEEKVQVTKVPEVSKKIVPQKPSRTPVQEE 9226

Query: 152  PLKASLPEPGAPARKPLQPDELSHPARPPSEPKSGAFPRKLWQPEAGE------ATPRSP 205
             ++  +P      +K +  +E    A    E  S   P    +    E      +    P
Sbjct: 9227 VIEVKVP--AVHTKKMVISEEKMFFASHTEEEVSVTVPEVQKEIVTEEKIHVAISKRVEP 9284

Query: 206  QPELSTFPKKPAQPEFNVYP----KKPPQPQVGGLPKKSVPQPEFSEAAQTPLWKPQSSE 261
             P++   P+KPA  E    P     +PP P+V  +PKK VP+    E    P+       
Sbjct: 9285 PPKVPELPEKPAPEEVAPVPIPKKVEPPAPKVPEVPKKPVPE----EKKPVPV------- 9333

Query: 262  PKRDSSAFPKKASQPPLSDFPKKPPQPELGDLTRTSSEPEVSVLPKRPRPAEFKALSKKP 321
            PK++ +A PK      + + PKKP   E                 K P P    A  K+ 
Sbjct: 9334 PKKEPAAPPK------VPEVPKKPVPEE-----------------KIPVPV---AKKKEA 9367

Query: 322  PQPELGGLPRTSSEPEFNSLPRKLLQPERRGPPRKFSQPEPSAVLKRHPQPEFFGDLPRK 381
            P  ++  + +     E  ++   + Q E   PP     P+     +R P P    ++P  
Sbjct: 9368 PPAKVPEVQKGVVTEEKITI---VTQREESPPPAVPEIPKKKVPEERKPVPRKEEEVPPP 9424

Query: 382  PPLPS 386
            P +P+
Sbjct: 9425 PKVPA 9429



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 116/562 (20%), Positives = 194/562 (34%), Gaps = 89/562 (15%)

Query: 56   PKKAPLPEFGAVSLKPPPP--EVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVT 113
            P   P PE      KPPP   EVT    K    +V   PK+  P E  ++ KKPPPP   
Sbjct: 8966 PLLLPTPE----EKKPPPKRIEVTKKAVKKDAKKVVAKPKEMTPRE--EIVKKPPPPTTL 9019

Query: 114  DLPKKPSKLELSDLSKKFPQLGATPFPRKPLQPEVGEAPLKASLPEPGAPARKPLQPDEL 173
               K P   E+ D+S K  ++      RK    +  EA  +    +      K +  +  
Sbjct: 9020 IPAKAP---EIIDVSSKAEEVKIMTITRKKEVQKEKEAVYE---KKQAVHKEKRVFIESF 9073

Query: 174  SHP-ARPPSEPKSGAFPRKLWQPEAGEATPRSPQPELSTFPKKPAQPEF-------NVYP 225
              P      EP +  F +  ++       P     E+    KK    E+         Y 
Sbjct: 9074 EEPYDELEVEPYTEPFEQPYYE------EPDEDYEEIKVEAKKEVHEEWEEDFEEGQEYY 9127

Query: 226  KKPPQPQVGGLPKKSVPQPEFSEAAQTPLWKPQSSEPKRDSSAFPKKASQPPLSDFPKKP 285
            ++      G    +   Q    E  Q      + S  ++  +  P+K + PP    PK  
Sbjct: 9128 EREEGYDEGEEEWEEAYQER--EVIQVQKEVYEESHERKVPAKVPEKKAPPP----PKVI 9181

Query: 286  PQPELGDLTRTSSE-----------PEVS--VLPKRP--RPAEFKALSKKPPQPELGGLP 330
             +P +  + +TS             PEVS  ++P++P   P + + +  K P      + 
Sbjct: 9182 KKPVIEKIEKTSRRMEEEKVQVTKVPEVSKKIVPQKPSRTPVQEEVIEVKVPAVHTKKMV 9241

Query: 331  RTSSEPEFNSLPRKLLQPERRGPPRKFSQPEP--SAVLKRHPQPEFFGDLPRKPPLPSSA 388
             +  +  F S   + +        ++    E    A+ KR   P    +LP K P P   
Sbjct: 9242 ISEEKMFFASHTEEEVSVTVPEVQKEIVTEEKIHVAISKRVEPPPKVPELPEK-PAPEEV 9300

Query: 389  SESSLPAAVAGFSSRHPLSPGFGAAGTPRWRSGGLVHSGGARPGLRPSHPPRRRPLP-PA 447
            +   +P  V   + + P  P                         +   P  ++P+P P 
Sbjct: 9301 APVPIPKKVEPPAPKVPEVP-------------------------KKPVPEEKKPVPVPK 9335

Query: 448  SSLGHPPAKPPLPPGPVDMQSFRRPSAASIDLRRTRSAAGLHFQDRQ-----PEDIPVPD 502
                 PP  P +P  PV  +    P A      + + A      + Q      E I +  
Sbjct: 9336 KEPAAPPKVPEVPKKPVPEEKIPVPVA------KKKEAPPAKVPEVQKGVVTEEKITIVT 9389

Query: 503  EIYELYDDVEPRDDSSPSPKGRDEAPSVQQAARRPPQDPALRKEKDPQPQQLPPMDPKLL 562
            +  E      P       P+ R   P  ++    PP+ PAL K+  P+ +   P+     
Sbjct: 9390 QREESPPPAVPEIPKKKVPEERKPVPRKEEEVPPPPKVPALPKKPVPEEKVAVPVPVAKK 9449

Query: 563  KQLRKAEKAEREFRKKFKFEGE 584
                +AE +++   ++ +F  E
Sbjct: 9450 APPPRAEVSKKTVVEEKRFVAE 9471



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 52/182 (28%), Positives = 75/182 (41%), Gaps = 23/182 (12%)

Query: 16    RSIKAKFQASQPEPSD-------LPKKP----PKPEFGKLKKFSQPELSEHPKKAPLPEF 64
             + ++      +PEP +       L K+P    PK E  KL+K  +P + E P   P+ E 
Sbjct: 10930 KKVRKLLPERKPEPKEEVVLKSVLRKRPEEEEPKVEPKKLEKVKKPAVPEPPPPKPVEEV 10989

Query: 65    GAVSL---KPPPPEVTDLPK-KPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPS 120
                ++   +   PE T +P+ KP  P     PK  P  EV  +  KPPP E    P   +
Sbjct: 10990 EVPTVTKRERKIPEPTKVPEIKPAIPLPAPEPKPKPEAEVKTI--KPPPVEPEPTP-IAA 11046

Query: 121   KLELSDLSKKFPQLGATPFPRKPLQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARPP 180
              + +  + KK           KP  P  G  P K   P P    R+ L+P   S   +PP
Sbjct: 11047 PVTVPVVGKKAEAKAPKEEAAKPKGPIKG-VPKKT--PSPIEAERRKLRPG--SGGEKPP 11101

Query: 181   SE 182
              E
Sbjct: 11102 DE 11103



 Score = 37.0 bits (84), Expect = 0.059
 Identities = 37/131 (28%), Positives = 52/131 (39%), Gaps = 19/131 (14%)

Query: 27    PEPSDLPKKPPKPEFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPP--PEVTDLPKKPP 84
             PEP+ +P+  P          + P  +  PK  P PE    ++KPPP  PE T +     
Sbjct: 11002 PEPTKVPEIKP----------AIPLPAPEPK--PKPEAEVKTIKPPPVEPEPTPIAAPVT 11049

Query: 85    PPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKK-PSKLELSDLSKKFPQLGATPFPRKP 143
              P V    +   P E    PK P    +  +PKK PS +E      +    G  P    P
Sbjct: 11050 VPVVGKKAEAKAPKEEAAKPKGP----IKGVPKKTPSPIEAERRKLRPGSGGEKPPDEAP 11105

Query: 144   LQPEVGEAPLK 154
                ++   PLK
Sbjct: 11106 FTYQLKAVPLK 11116


>gi|61966919 hypothetical protein LOC442444 [Homo sapiens]
          Length = 1035

 Score =  103 bits (258), Expect = 4e-22
 Identities = 126/496 (25%), Positives = 190/496 (38%), Gaps = 63/496 (12%)

Query: 21  KFQASQPEP--SDLPKKPPKPEFGKLKKFSQPE--LSEHPKKAPLPEFGAVSLKPPPPEV 76
           +F    PE   S LP +PPK     L+    PE  +S    + P  +  ++ L+PP   V
Sbjct: 185 EFSPRPPETRVSCLPPEPPKTPVSSLRP-EPPETGVSHLRPQPPKTQVSSLHLEPPETGV 243

Query: 77  TDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPSKLELSDLSKKFPQLGA 136
           + L  +PP  +V+ L  +PP   V+ L  +PP   V+ L  +P K  +S L ++ P+ G 
Sbjct: 244 SHLRPEPPKTQVSSLHLEPPETGVSHLYLEPPGTGVSHLCPEPPKTRVSHLHREPPETGV 303

Query: 137 TPFPRKP-------LQPEVGEAPLKASLPEPGAPARKPLQPDE----LSHPARPPSEPKS 185
                +P       L+PE  E  +    PEP       L P+     +SH    P  P++
Sbjct: 304 PDLCLEPPKSRVSHLRPEPSETGVSHLHPEPPKTLVSSLHPEPPETGVSHLC--PEPPET 361

Query: 186 GAFPRKLWQPEAGEATPRSPQPELSTFPKKPAQPEFNVYP--KKPPQPQVGGLPKKSVPQ 243
              P +   PEAG +      P+    P +P  P+  V P   +PP+ ++  L  +    
Sbjct: 362 RVSPLRQLPPEAGVSHLCPEPPKTRVPPLRPETPKNGVSPLFPEPPKTRISNLRSEPPKI 421

Query: 244 PEFSEAAQTPLWKPQSSEPKRDSSAFPKKASQPP---LSDFPKKPPQPELGDLTRTSSEP 300
                  + P  +     P+   +       +PP   +S    +PP+  +  L     E 
Sbjct: 422 GVSHLCLEPPKTRGSHLRPEPPETGVSHLRPEPPKTRVSSLHLEPPETGVSHLCPEPPEK 481

Query: 301 EVSVLPKRPRPAEFKALSKKPPQPELGGLPRTSSEPEFNSL----PRKLLQPERRGPPR- 355
           +VS L   P       L  +PP+  +  L    SE   + L    P+ L+    + PP  
Sbjct: 482 DVSHLRPEPPDTGVSHLCPEPPKTRVSHLRPEPSETGVSHLRPEPPKILVSSLHQAPPES 541

Query: 356 --KFSQPEPSAVLKRHPQPE-----FFGDLPRKP--------PLPSSASESSLP--AAVA 398
                +PEP      H +PE      +   P  P        P P     SSLP      
Sbjct: 542 SVSHLRPEPPETGVSHLRPEPPKTRMYSLRPEPPDTGVSHLCPEPPKTRVSSLPPEPPET 601

Query: 399 GFSSRHPLSPGFGAAG-TPRWRSGGLVHSGGARPGLRPSHPPRR----RPLPPASSLGHP 453
           G S   P  P    +   P     G+ H       LRP  P  R    RP PP + + H 
Sbjct: 602 GVSHLCPEPPETRVSHLRPEPPETGVSH-------LRPEPPKTRMYSLRPEPPNTGVSHL 654

Query: 454 PAKPP------LPPGP 463
             +PP      LPP P
Sbjct: 655 CPEPPKTRVSSLPPEP 670



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 95/375 (25%), Positives = 152/375 (40%), Gaps = 41/375 (10%)

Query: 27  PEP-----SDLPKKPPKPEFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPPPE--VTDL 79
           PEP     S+L  +PPK     L          H +  P PE G   L+P PP+  V+ L
Sbjct: 404 PEPPKTRISNLRSEPPKIGVSHLCLEPPKTRGSHLRPEP-PETGVSHLRPEPPKTRVSSL 462

Query: 80  PKKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPSKLELSDLSKKFPQLGATPF 139
             +PP   V+ L  +PP  +V+ L  +PP   V+ L  +P K  +S L  +  + G +  
Sbjct: 463 HLEPPETGVSHLCPEPPEKDVSHLRPEPPDTGVSHLCPEPPKTRVSHLRPEPSETGVSHL 522

Query: 140 PRKPLQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARPPSEPKSGAFPRKLWQPEAGE 199
             +P  P++  + L  + PE      +P +P E       P  PK+  +  +   P+ G 
Sbjct: 523 --RPEPPKILVSSLHQAPPESSVSHLRP-EPPETGVSHLRPEPPKTRMYSLRPEPPDTGV 579

Query: 200 A--TPRSPQPELSTFPKKPAQPEFNVYPKKPPQPQVGGLPKKSVPQPEFSEAA-QTPLWK 256
           +   P  P+  +S+ P +P +   +    +PP+ +V  L +   P+   S    + P  +
Sbjct: 580 SHLCPEPPKTRVSSLPPEPPETGVSHLCPEPPETRVSHL-RPEPPETGVSHLRPEPPKTR 638

Query: 257 PQSSEPKRDSSAFPKKASQPPLSDFPKKPPQPELGDLTRTSSEPEVSVLPKRPRPAEFKA 316
             S  P+  ++       +PP +     PP+P           PE  V    P P E + 
Sbjct: 639 MYSLRPEPPNTGVSHLCPEPPKTRVSSLPPEP-----------PETGVSHLCPEPPETRV 687

Query: 317 LSKKPPQPELGGLPRTSSEPEFNSLPRKLLQPERRGPPRKFSQPEPSAVLKRHPQPEFFG 376
              +P  PE G + R   EP     P+  +      PP        S V    P+P   G
Sbjct: 688 SHLRPEPPETG-VSRLHPEP-----PKTRVSSLHAEPPE-------SRVSHLCPEPPETG 734

Query: 377 --DLPRKPPLPSSAS 389
              L  +PP P  +S
Sbjct: 735 VSHLRPEPPKPRVSS 749



 Score = 87.8 bits (216), Expect = 3e-17
 Identities = 96/367 (26%), Positives = 147/367 (40%), Gaps = 53/367 (14%)

Query: 26  QPEPSD-----LPKKPPKPEFGKLKKFSQPELSE----HPKKAPLPEFGAVSLKPPPPEV 76
           +PEP D     L  +PPK     L+    PE SE    H +  P P+    SL   PPE 
Sbjct: 487 RPEPPDTGVSHLCPEPPKTRVSHLR----PEPSETGVSHLRPEP-PKILVSSLHQAPPES 541

Query: 77  TDLPKKPPPPE--VTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPSKLELSDLSKKFPQL 134
           +    +P PPE  V+ L  +PP   +  L  +PP   V+ L  +P K  +S L  + P+ 
Sbjct: 542 SVSHLRPEPPETGVSHLRPEPPKTRMYSLRPEPPDTGVSHLCPEPPKTRVSSLPPEPPET 601

Query: 135 GATPFPRKPLQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARPPSEPKSGAFPRKLWQ 194
           G +    +P  PE   + L+   PE G    +P  P    +  RP   P +G        
Sbjct: 602 GVSHLCPEP--PETRVSHLRPEPPETGVSHLRPEPPKTRMYSLRP-EPPNTGV------- 651

Query: 195 PEAGEATPRSPQPELSTFPKKPAQPEFNVYPKKPPQPQVGGLPKKSVPQPEFSEAAQTPL 254
                  P  P+  +S+ P +P +   +    +PP+ +V  L     P+P      +T +
Sbjct: 652 ---SHLCPEPPKTRVSSLPPEPPETGVSHLCPEPPETRVSHLR----PEPP-----ETGV 699

Query: 255 WKPQSSEPKRDSSAFPKKASQPPLSDFPKKPPQPELGDLTRTSSEPEVSVLPKRPRPAEF 314
            +     PK   S+   +  +  +S    +PP+  +  L     +P VS L  RP P E 
Sbjct: 700 SRLHPEPPKTRVSSLHAEPPESRVSHLCPEPPETGVSHLRPEPPKPRVSSL--RPEPLET 757

Query: 315 KALSKKPPQPELG--------GLPRTSS----EPEFNSLPRKLLQPERRGPPRKFSQPEP 362
           +    +P  PE G          PR SS     P+   +    L+P + G       PEP
Sbjct: 758 RVSHLRPEPPETGVSHLHPELPKPRVSSLHLEPPKTRRVSSLRLEPPKTGRVSSLC-PEP 816

Query: 363 SAVLKRH 369
           +     H
Sbjct: 817 TKTGASH 823



 Score = 87.0 bits (214), Expect = 5e-17
 Identities = 119/452 (26%), Positives = 169/452 (37%), Gaps = 75/452 (16%)

Query: 56  PKKAPLPEFGAVSLKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDL 115
           P K P  EF   S +PP   V+ LP +PP   V+ L  +PP   V+ L  +PP  +V+ L
Sbjct: 178 PGKYPCGEF---SPRPPETRVSCLPPEPPKTPVSSLRPEPPETGVSHLRPQPPKTQVSSL 234

Query: 116 PKKPSKLELSDLSKKFPQLGATPFPRKPLQPEVGEAPLKASLPEPGAPARKPLQP-DELS 174
             +P +  +S L  + P+   +    +P  PE G + L    P  G     P  P   +S
Sbjct: 235 HLEPPETGVSHLRPEPPKTQVSSLHLEP--PETGVSHLYLEPPGTGVSHLCPEPPKTRVS 292

Query: 175 HPARPPSE----------PKSGAFPRKLWQPEAG--EATPRSPQPELSTFPKKPAQ---- 218
           H  R P E          PKS     +    E G     P  P+  +S+   +P +    
Sbjct: 293 HLHREPPETGVPDLCLEPPKSRVSHLRPEPSETGVSHLHPEPPKTLVSSLHPEPPETGVS 352

Query: 219 ------PEFNVYPKK--PPQPQVGGL----PKKSVP--QPEFSEAAQTPLWKPQSSEPKR 264
                 PE  V P +  PP+  V  L    PK  VP  +PE  +   +PL+      P+ 
Sbjct: 353 HLCPEPPETRVSPLRQLPPEAGVSHLCPEPPKTRVPPLRPETPKNGVSPLF------PEP 406

Query: 265 DSSAFPKKASQPP---LSDFPKKPPQPELGDLTRTSSEPEVSVLPKRPRPAEFKALSKKP 321
             +      S+PP   +S    +PP+     L     E  VS L   P      +L  +P
Sbjct: 407 PKTRISNLRSEPPKIGVSHLCLEPPKTRGSHLRPEPPETGVSHLRPEPPKTRVSSLHLEP 466

Query: 322 PQPELGGLPRTSSEPEFNSLPRKLLQPERRGPPRKFSQPEPSAVLKRHPQPEFFGDLPRK 381
           P+    G+     EP    +     +P   G      +P  + V    P+P   G +   
Sbjct: 467 PET---GVSHLCPEPPEKDVSHLRPEPPDTGVSHLCPEPPKTRVSHLRPEPSETG-VSHL 522

Query: 382 PPLPSSASESSLPAAVAGFSSRHPLSPGFGAAGTPRWRSGGLVHSGGARPGLRPSHPPRR 441
            P P     SSL  A    S  H           P     G+ H       LRP  P  R
Sbjct: 523 RPEPPKILVSSLHQAPPESSVSHL---------RPEPPETGVSH-------LRPEPPKTR 566

Query: 442 ----RPLPPASSLGHPPAKPP------LPPGP 463
               RP PP + + H   +PP      LPP P
Sbjct: 567 MYSLRPEPPDTGVSHLCPEPPKTRVSSLPPEP 598



 Score = 83.6 bits (205), Expect = 5e-16
 Identities = 86/365 (23%), Positives = 139/365 (38%), Gaps = 24/365 (6%)

Query: 27  PEPSDLPKKPPKPEFGKLKKFSQPELSEHPKKAP-LPEFGAVSLKPPPPE--VTDLPKKP 83
           PE    P +   PE G      +P  +  P   P  P+ G   L P PP+  +++L  +P
Sbjct: 359 PETRVSPLRQLPPEAGVSHLCPEPPKTRVPPLRPETPKNGVSPLFPEPPKTRISNLRSEP 418

Query: 84  PPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPSKLELSDLSKKFPQLGATPFPRKP 143
           P   V+ L  +PP    + L  +PP   V+ L  +P K  +S L  + P+ G +    +P
Sbjct: 419 PKIGVSHLCLEPPKTRGSHLRPEPPETGVSHLRPEPPKTRVSSLHLEPPETGVSHLCPEP 478

Query: 144 -------LQPEVGEAPLKASLPEPGAPARKPLQPD--ELSHPARPPSEPKSGAFPRKLWQ 194
                  L+PE  +  +    PEP       L+P+  E       P  PK          
Sbjct: 479 PEKDVSHLRPEPPDTGVSHLCPEPPKTRVSHLRPEPSETGVSHLRPEPPKILVSSLHQAP 538

Query: 195 PEAGEATPRSPQPELSTFPKKPAQPEFNVYPKKPPQPQVGGLPKKSVPQPEFSEAAQTPL 254
           PE+  +  R   PE      +P  P+  +Y  +P  P  G       P+P  +  +  P 
Sbjct: 539 PESSVSHLRPEPPETGVSHLRPEPPKTRMYSLRPEPPDTG--VSHLCPEPPKTRVSSLPP 596

Query: 255 WKPQSSE----PKRDSSAFPKKASQPP---LSDFPKKPPQPELGDLTRTSSEPEVSVLPK 307
             P++      P+   +       +PP   +S    +PP+  +  L      P   V   
Sbjct: 597 EPPETGVSHLCPEPPETRVSHLRPEPPETGVSHLRPEPPKTRMYSLR--PEPPNTGVSHL 654

Query: 308 RPRPAEFKALSKKPPQPELGGLPRTSSEPEFNSLPRKLLQPERRGPPRKFSQPEPSAVLK 367
            P P + + +S  PP+P   G+     EP    +     +P   G  R   +P  + V  
Sbjct: 655 CPEPPKTR-VSSLPPEPPETGVSHLCPEPPETRVSHLRPEPPETGVSRLHPEPPKTRVSS 713

Query: 368 RHPQP 372
            H +P
Sbjct: 714 LHAEP 718



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 92/396 (23%), Positives = 147/396 (37%), Gaps = 24/396 (6%)

Query: 69  LKPPPPE--VTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPSKLELSD 126
           LKP  PE  + D        + TD P +P      +   +PP   V+ LP +P K  +S 
Sbjct: 150 LKPLDPERKLEDAGSCEGQEKTTDEPTEPGKYPCGEFSPRPPETRVSCLPPEPPKTPVSS 209

Query: 127 LSKKFPQLGATPFPRKPLQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARPPSEPKSG 186
           L  + P+ G +    +P  P+   + L    PE G    +P +P +    +     P++G
Sbjct: 210 LRPEPPETGVSHL--RPQPPKTQVSSLHLEPPETGVSHLRP-EPPKTQVSSLHLEPPETG 266

Query: 187 AFPRKLWQPEAG--EATPRSPQPELSTFPKKPAQPEFNVYPKKPPQPQVGGLPKKSVPQP 244
                L  P  G     P  P+  +S   ++P +        +PP+ +V  L      +P
Sbjct: 267 VSHLYLEPPGTGVSHLCPEPPKTRVSHLHREPPETGVPDLCLEPPKSRVSHL------RP 320

Query: 245 EFSEAAQTPLWKPQSSEPKRDSSAFPKKASQPPLSDFPKKPPQPELGDLTRTSSEPEVSV 304
           E SE   + L       PK   S+   +  +  +S    +PP+  +  L +    PE  V
Sbjct: 321 EPSETGVSHL---HPEPPKTLVSSLHPEPPETGVSHLCPEPPETRVSPLRQL--PPEAGV 375

Query: 305 LPKRPRPAEFKALSKKPPQPELGGLPRTSSEPEFNSLPRKLLQPERRGPPRKFSQPEPSA 364
               P P + +    +P  P+ G  P    EP    +     +P + G      +P  + 
Sbjct: 376 SHLCPEPPKTRVPPLRPETPKNGVSP-LFPEPPKTRISNLRSEPPKIGVSHLCLEPPKTR 434

Query: 365 VLKRHPQPEFFGDLPRKPPLPSS-ASESSLPAAVAGFSSRHPLSPGFGAAG-TPRWRSGG 422
                P+P   G    +P  P +  S   L     G S   P  P    +   P     G
Sbjct: 435 GSHLRPEPPETGVSHLRPEPPKTRVSSLHLEPPETGVSHLCPEPPEKDVSHLRPEPPDTG 494

Query: 423 LVHSGGARPGLRPSHPPRRRPLPPASSLGHPPAKPP 458
           + H     P  R SH    RP P  + + H   +PP
Sbjct: 495 VSHLCPEPPKTRVSH---LRPEPSETGVSHLRPEPP 527


>gi|148727245 thioredoxin domain-containing 2 isoform 1 [Homo
           sapiens]
          Length = 486

 Score =  103 bits (256), Expect = 7e-22
 Identities = 103/374 (27%), Positives = 170/374 (45%), Gaps = 64/374 (17%)

Query: 19  KAKFQASQPEPSDLPKKPPK---PEFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPPPE 75
           K+    S P+  D PK   +   P+ G + K   PE +   KK  LP+    +++P   +
Sbjct: 24  KSSANTSHPKQDDSPKSSEETIQPKEGDIPK--APEETIQSKKEDLPKSSEKAIQP---K 78

Query: 76  VTDLPK---KPPPPEVTDLPK---KPPPPEVTDLPKKPP---PPEVTDLPKKPSKLELSD 126
            +++PK   KP  P++ ++PK   KP  P+  D+PK P      +  DLPK  S+  +  
Sbjct: 79  ESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQSKKEDLPKS-SEEAIQP 137

Query: 127 LSKKFPQLGATPFPRKPLQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARPPS--EPK 184
                P+  A     KP+QP++G    K S+        KP QP E   P  P    +PK
Sbjct: 138 KEGDIPKSSA-----KPIQPKLGNI-AKTSV--------KPSQPKESDIPKSPEETIQPK 183

Query: 185 SGAFPR---KLWQPEAGEATPRSPQPELSTFPKKPAQPEFNVYPKKPPQPQVGGLPK--K 239
            G  P+   K  QP+ G        P+ S  P +P + + +  P++  QP+ G LPK  +
Sbjct: 184 EGDIPKSSAKPIQPKLGNI------PKASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLE 237

Query: 240 SVPQPEFSEAAQTPLWKPQSSEPKR-DSSAFPKKASQPPLSDFPKKPP---QPELGDLTR 295
              QP+  +  ++P    ++ +PK  D     ++A QP   D PK P    QP+ GD+ +
Sbjct: 238 EAIQPKEGDIPKSP---EEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGDIPK 294

Query: 296 TSSEPEVSVLPKRPRPAEFKALSKKPPQPELGGLPRTSSEP------EFNSLPRKLLQPE 349
           +   PE ++ PK     +     K+  QP+ G +P++  E       +    P + +QP+
Sbjct: 295 S---PEEAIQPKE---GDIPKSPKQAIQPKEGDIPKSLEEAIPPKEIDIPKSPEETIQPK 348

Query: 350 RRGPPRKFSQPEPS 363
               P+   +  PS
Sbjct: 349 EDDSPKSLEEATPS 362



 Score = 93.6 bits (231), Expect = 5e-19
 Identities = 94/334 (28%), Positives = 157/334 (47%), Gaps = 70/334 (20%)

Query: 17  SIKAKFQASQPEPSDLPKKPPKPEFGKLKKFSQPELSE---HPKKAPLPEFGA------- 66
           S K+  +  QP+  D+PK P   E  + KK   P+ SE    PK++ +P+  A       
Sbjct: 37  SPKSSEETIQPKEGDIPKAPE--ETIQSKKEDLPKSSEKAIQPKESNIPKSSAKPIQPKL 94

Query: 67  -----VSLKPPPPEVTDLPKKPP---PPEVTDLPKKPP---PPEVTDLPK---KPPPPEV 112
                 S+KP  P+  D+PK P      +  DLPK       P+  D+PK   KP  P++
Sbjct: 95  GNIPKASVKPSQPKEGDIPKAPEETIQSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKL 154

Query: 113 TDLPK---KPSKLELSDLSKKFPQLGATPFPRKPLQPEVGEAPLKASLPEPGAPARKPLQ 169
            ++ K   KPS+ + SD+ K          P + +QP+ G+ P  ++         KP+Q
Sbjct: 155 GNIAKTSVKPSQPKESDIPKS---------PEETIQPKEGDIPKSSA---------KPIQ 196

Query: 170 P--DELSHPARPPSEPKSGAF---PRKLWQPEAGEATPRSPQPELSTFPKKPAQPEFNVY 224
           P    +   +  PS+PK G     P +  QP+ G+  P+S +  +     +P + +    
Sbjct: 197 PKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGD-LPKSLEEAI-----QPKEGDIPKS 250

Query: 225 PKKPPQPQVGGLPK--KSVPQPEFSEAAQTPLWKPQSSEPKR-DSSAFPKKASQPPLSDF 281
           P++  QP+ G +PK  +   QP+  +  ++P    ++ +PK+ D    P++A QP   D 
Sbjct: 251 PEEAIQPKEGDIPKSLEEAIQPKEGDIPKSP---EETIQPKKGDIPKSPEEAIQPKEGDI 307

Query: 282 PKKPP---QPELGDLTRTSSE---PEVSVLPKRP 309
           PK P    QP+ GD+ ++  E   P+   +PK P
Sbjct: 308 PKSPKQAIQPKEGDIPKSLEEAIPPKEIDIPKSP 341



 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 94/350 (26%), Positives = 152/350 (43%), Gaps = 39/350 (11%)

Query: 75  EVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPSKLELSDLSKKFPQL 134
           E  DLPK             P   E T  PK+   P+  +   +  K +L   S+K  Q 
Sbjct: 18  EGDDLPKSSANTSHPKQDDSPKSSEETIQPKEGDIPKAPEETIQSKKEDLPKSSEKAIQP 77

Query: 135 GATPFPR---KPLQPEVGEAP---LKASLPEPGAPARKP-----LQPDELSHPARPPSEP 183
             +  P+   KP+QP++G  P   +K S P+ G   + P      + ++L   +    +P
Sbjct: 78  KESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQSKKEDLPKSSEEAIQP 137

Query: 184 KSGAFPR---KLWQPEAG---EATPRSPQPELSTFPKKP---AQPEFNVYPK---KPPQP 231
           K G  P+   K  QP+ G   + + +  QP+ S  PK P    QP+    PK   KP QP
Sbjct: 138 KEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETIQPKEGDIPKSSAKPIQP 197

Query: 232 QVGGLPKKSV--PQPEFSEAAQTPLWKPQSSEPKR-DSSAFPKKASQPPLSDFPKKPP-- 286
           ++G +PK SV   QP+  + +++P    ++ +PK  D     ++A QP   D PK P   
Sbjct: 198 KLGNIPKASVKPSQPKEGDISKSP---EEAIQPKEGDLPKSLEEAIQPKEGDIPKSPEEA 254

Query: 287 -QPELGDLTRTSSE---PEVSVLPKRPRPAEFKALSKKPPQPELGGLPRTSSEPEFNSLP 342
            QP+ GD+ ++  E   P+   +PK P           P  PE    P+    P+    P
Sbjct: 255 IQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGDIPKSPEEAIQPKEGDIPK---SP 311

Query: 343 RKLLQPERRGPPRKFSQPEPSAVLKRHPQPEFFGDLPRKPPLPSSASESS 392
           ++ +QP+    P+   +  P   +     PE     P++   P S  E++
Sbjct: 312 KQAIQPKEGDIPKSLEEAIPPKEIDIPKSPEETIQ-PKEDDSPKSLEEAT 360



 Score = 70.1 bits (170), Expect = 6e-12
 Identities = 97/409 (23%), Positives = 161/409 (39%), Gaps = 82/409 (20%)

Query: 157 LPEPGAPARKPLQPDELSHPARPPSEPKSGAFPRKLWQPEAGEATPRSPQPELSTFPKKP 216
           LP+  A    P Q D+    +    +PK G  P+      A E T +S + +L    +K 
Sbjct: 22  LPKSSANTSHPKQ-DDSPKSSEETIQPKEGDIPK------APEETIQSKKEDLPKSSEKA 74

Query: 217 AQPEFNVYPK---KPPQPQVGGLPKKSVPQPEFSEAAQTPLWKPQSSEPKRDSSAFPKKA 273
            QP+ +  PK   KP QP++G +PK SV                              K 
Sbjct: 75  IQPKESNIPKSSAKPIQPKLGNIPKASV------------------------------KP 104

Query: 274 SQPPLSDFPKKPP---QPELGDLTRTSSEPEVSVLPKRPRPAEFKALSKKPPQPELGGLP 330
           SQP   D PK P    Q +  DL ++S E        +P+  +    S KP QP+LG + 
Sbjct: 105 SQPKEGDIPKAPEETIQSKKEDLPKSSEEAI------QPKEGDIPKSSAKPIQPKLGNIA 158

Query: 331 RTS---SEPEFNSLPR---KLLQPERRGPPRKFSQP-------EPSAVLKRHPQPEFFGD 377
           +TS   S+P+ + +P+   + +QP+    P+  ++P        P A +K  P     GD
Sbjct: 159 KTSVKPSQPKESDIPKSPEETIQPKEGDIPKSSAKPIQPKLGNIPKASVK--PSQPKEGD 216

Query: 378 LPRKPPLPSSASESSLPAAVAGFSSRHPLSPGFGAAGTPRWRSGGLVHSGGARP-GLRPS 436
           + + P       E  LP      S    + P  G    P+     +    G  P  L  +
Sbjct: 217 ISKSPEEAIQPKEGDLPK-----SLEEAIQPKEG--DIPKSPEEAIQPKEGDIPKSLEEA 269

Query: 437 HPPRRRPLPPASSLGHPPAKPPLPPGP---VDMQSFRRPSAASIDLRRTRSAAGLHFQDR 493
             P+   +P +      P K  +P  P   +  +    P +    ++          ++ 
Sbjct: 270 IQPKEGDIPKSPEETIQPKKGDIPKSPEEAIQPKEGDIPKSPKQAIQPKEGDIPKSLEEA 329

Query: 494 -QPEDIPVPDEIYELYDDVEPRDDSSPSPKGRDEA-PSVQQAARRPPQD 540
             P++I +P    E    ++P++D   SPK  +EA PS +    +P ++
Sbjct: 330 IPPKEIDIPKSPEE---TIQPKEDD--SPKSLEEATPSKEGDILKPEEE 373



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 34/122 (27%), Positives = 62/122 (50%), Gaps = 13/122 (10%)

Query: 19  KAKFQASQPEPSDLPKKPPK---PEFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPPPE 75
           K+  +A QP+  D+PK P +   P+ G + K   PE +  PK+  +P+    +++P   +
Sbjct: 264 KSLEEAIQPKEGDIPKSPEETIQPKKGDIPK--SPEEAIQPKEGDIPKSPKQAIQPKEGD 321

Query: 76  VTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPSK----LELSDLSKKF 131
           +    ++  PP+  D+PK    PE T  PK+   P+  +    PSK    L+  + + +F
Sbjct: 322 IPKSLEEAIPPKEIDIPKS---PEETIQPKEDDSPKSLE-EATPSKEGDILKPEEETMEF 377

Query: 132 PQ 133
           P+
Sbjct: 378 PE 379



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 61/320 (19%), Positives = 119/320 (37%), Gaps = 61/320 (19%)

Query: 256 KPQSSEPKRDSSAFPKKASQPPLSDFPKKPPQPELGDLTRTSSEPEVSVLPKRP------ 309
           + + S+  ++    PK ++    +  PK+   P+  + T    +P+   +PK P      
Sbjct: 9   RTEESDASQEGDDLPKSSAN---TSHPKQDDSPKSSEET---IQPKEGDIPKAPEETIQS 62

Query: 310 RPAEFKALSKKPPQPELGGLPRTSS---EPEFNSLPRKLLQPERRGPPRKFSQPEPSAVL 366
           +  +    S+K  QP+   +P++S+   +P+  ++P+  ++P +         PE +   
Sbjct: 63  KKEDLPKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQS 122

Query: 367 KRHPQPEFFGDLPRKPPLPSSASESSLPAAVAGFSSRHPLSPGFGAAGTPRWRSGGLVHS 426
           K+        DLP+         E  +P      SS  P+ P  G               
Sbjct: 123 KKE-------DLPKSSEEAIQPKEGDIPK-----SSAKPIQPKLGNI------------- 157

Query: 427 GGARPGLRPSHP--------PRRRPLPPASSLGHPPAKPPLPP-GPVDMQSFRRPSAASI 477
             A+  ++PS P        P     P    +    AKP  P  G +   S +       
Sbjct: 158 --AKTSVKPSQPKESDIPKSPEETIQPKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEG 215

Query: 478 DLRRTRSAAGLHFQDRQPEDIPVPDEIYELYD----DVEPRDDSSPSPKGRDEAPSVQQA 533
           D+ ++   A       QP++  +P  + E       D+    + +  PK  D   S+++A
Sbjct: 216 DISKSPEEA------IQPKEGDLPKSLEEAIQPKEGDIPKSPEEAIQPKEGDIPKSLEEA 269

Query: 534 ARRPPQDPALRKEKDPQPQQ 553
            +    D     E+  QP++
Sbjct: 270 IQPKEGDIPKSPEETIQPKK 289


>gi|148727319 thioredoxin domain-containing 2 isoform 2 [Homo
           sapiens]
          Length = 553

 Score =  103 bits (256), Expect = 7e-22
 Identities = 103/374 (27%), Positives = 170/374 (45%), Gaps = 64/374 (17%)

Query: 19  KAKFQASQPEPSDLPKKPPK---PEFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPPPE 75
           K+    S P+  D PK   +   P+ G + K   PE +   KK  LP+    +++P   +
Sbjct: 91  KSSANTSHPKQDDSPKSSEETIQPKEGDIPK--APEETIQSKKEDLPKSSEKAIQP---K 145

Query: 76  VTDLPK---KPPPPEVTDLPK---KPPPPEVTDLPKKPP---PPEVTDLPKKPSKLELSD 126
            +++PK   KP  P++ ++PK   KP  P+  D+PK P      +  DLPK  S+  +  
Sbjct: 146 ESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQSKKEDLPKS-SEEAIQP 204

Query: 127 LSKKFPQLGATPFPRKPLQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARPPS--EPK 184
                P+  A     KP+QP++G    K S+        KP QP E   P  P    +PK
Sbjct: 205 KEGDIPKSSA-----KPIQPKLGNI-AKTSV--------KPSQPKESDIPKSPEETIQPK 250

Query: 185 SGAFPR---KLWQPEAGEATPRSPQPELSTFPKKPAQPEFNVYPKKPPQPQVGGLPK--K 239
            G  P+   K  QP+ G        P+ S  P +P + + +  P++  QP+ G LPK  +
Sbjct: 251 EGDIPKSSAKPIQPKLGNI------PKASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLE 304

Query: 240 SVPQPEFSEAAQTPLWKPQSSEPKR-DSSAFPKKASQPPLSDFPKKPP---QPELGDLTR 295
              QP+  +  ++P    ++ +PK  D     ++A QP   D PK P    QP+ GD+ +
Sbjct: 305 EAIQPKEGDIPKSP---EEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGDIPK 361

Query: 296 TSSEPEVSVLPKRPRPAEFKALSKKPPQPELGGLPRTSSEP------EFNSLPRKLLQPE 349
           +   PE ++ PK     +     K+  QP+ G +P++  E       +    P + +QP+
Sbjct: 362 S---PEEAIQPKE---GDIPKSPKQAIQPKEGDIPKSLEEAIPPKEIDIPKSPEETIQPK 415

Query: 350 RRGPPRKFSQPEPS 363
               P+   +  PS
Sbjct: 416 EDDSPKSLEEATPS 429



 Score = 93.6 bits (231), Expect = 5e-19
 Identities = 94/334 (28%), Positives = 157/334 (47%), Gaps = 70/334 (20%)

Query: 17  SIKAKFQASQPEPSDLPKKPPKPEFGKLKKFSQPELSE---HPKKAPLPEFGA------- 66
           S K+  +  QP+  D+PK P   E  + KK   P+ SE    PK++ +P+  A       
Sbjct: 104 SPKSSEETIQPKEGDIPKAPE--ETIQSKKEDLPKSSEKAIQPKESNIPKSSAKPIQPKL 161

Query: 67  -----VSLKPPPPEVTDLPKKPP---PPEVTDLPKKPP---PPEVTDLPK---KPPPPEV 112
                 S+KP  P+  D+PK P      +  DLPK       P+  D+PK   KP  P++
Sbjct: 162 GNIPKASVKPSQPKEGDIPKAPEETIQSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKL 221

Query: 113 TDLPK---KPSKLELSDLSKKFPQLGATPFPRKPLQPEVGEAPLKASLPEPGAPARKPLQ 169
            ++ K   KPS+ + SD+ K          P + +QP+ G+ P  ++         KP+Q
Sbjct: 222 GNIAKTSVKPSQPKESDIPKS---------PEETIQPKEGDIPKSSA---------KPIQ 263

Query: 170 P--DELSHPARPPSEPKSGAF---PRKLWQPEAGEATPRSPQPELSTFPKKPAQPEFNVY 224
           P    +   +  PS+PK G     P +  QP+ G+  P+S +  +     +P + +    
Sbjct: 264 PKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGD-LPKSLEEAI-----QPKEGDIPKS 317

Query: 225 PKKPPQPQVGGLPK--KSVPQPEFSEAAQTPLWKPQSSEPKR-DSSAFPKKASQPPLSDF 281
           P++  QP+ G +PK  +   QP+  +  ++P    ++ +PK+ D    P++A QP   D 
Sbjct: 318 PEEAIQPKEGDIPKSLEEAIQPKEGDIPKSP---EETIQPKKGDIPKSPEEAIQPKEGDI 374

Query: 282 PKKPP---QPELGDLTRTSSE---PEVSVLPKRP 309
           PK P    QP+ GD+ ++  E   P+   +PK P
Sbjct: 375 PKSPKQAIQPKEGDIPKSLEEAIPPKEIDIPKSP 408



 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 94/350 (26%), Positives = 152/350 (43%), Gaps = 39/350 (11%)

Query: 75  EVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPSKLELSDLSKKFPQL 134
           E  DLPK             P   E T  PK+   P+  +   +  K +L   S+K  Q 
Sbjct: 85  EGDDLPKSSANTSHPKQDDSPKSSEETIQPKEGDIPKAPEETIQSKKEDLPKSSEKAIQP 144

Query: 135 GATPFPR---KPLQPEVGEAP---LKASLPEPGAPARKP-----LQPDELSHPARPPSEP 183
             +  P+   KP+QP++G  P   +K S P+ G   + P      + ++L   +    +P
Sbjct: 145 KESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQSKKEDLPKSSEEAIQP 204

Query: 184 KSGAFPR---KLWQPEAG---EATPRSPQPELSTFPKKP---AQPEFNVYPK---KPPQP 231
           K G  P+   K  QP+ G   + + +  QP+ S  PK P    QP+    PK   KP QP
Sbjct: 205 KEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETIQPKEGDIPKSSAKPIQP 264

Query: 232 QVGGLPKKSV--PQPEFSEAAQTPLWKPQSSEPKR-DSSAFPKKASQPPLSDFPKKPP-- 286
           ++G +PK SV   QP+  + +++P    ++ +PK  D     ++A QP   D PK P   
Sbjct: 265 KLGNIPKASVKPSQPKEGDISKSP---EEAIQPKEGDLPKSLEEAIQPKEGDIPKSPEEA 321

Query: 287 -QPELGDLTRTSSE---PEVSVLPKRPRPAEFKALSKKPPQPELGGLPRTSSEPEFNSLP 342
            QP+ GD+ ++  E   P+   +PK P           P  PE    P+    P+    P
Sbjct: 322 IQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGDIPKSPEEAIQPKEGDIPK---SP 378

Query: 343 RKLLQPERRGPPRKFSQPEPSAVLKRHPQPEFFGDLPRKPPLPSSASESS 392
           ++ +QP+    P+   +  P   +     PE     P++   P S  E++
Sbjct: 379 KQAIQPKEGDIPKSLEEAIPPKEIDIPKSPEETIQ-PKEDDSPKSLEEAT 427



 Score = 70.1 bits (170), Expect = 6e-12
 Identities = 97/409 (23%), Positives = 161/409 (39%), Gaps = 82/409 (20%)

Query: 157 LPEPGAPARKPLQPDELSHPARPPSEPKSGAFPRKLWQPEAGEATPRSPQPELSTFPKKP 216
           LP+  A    P Q D+    +    +PK G  P+      A E T +S + +L    +K 
Sbjct: 89  LPKSSANTSHPKQ-DDSPKSSEETIQPKEGDIPK------APEETIQSKKEDLPKSSEKA 141

Query: 217 AQPEFNVYPK---KPPQPQVGGLPKKSVPQPEFSEAAQTPLWKPQSSEPKRDSSAFPKKA 273
            QP+ +  PK   KP QP++G +PK SV                              K 
Sbjct: 142 IQPKESNIPKSSAKPIQPKLGNIPKASV------------------------------KP 171

Query: 274 SQPPLSDFPKKPP---QPELGDLTRTSSEPEVSVLPKRPRPAEFKALSKKPPQPELGGLP 330
           SQP   D PK P    Q +  DL ++S E        +P+  +    S KP QP+LG + 
Sbjct: 172 SQPKEGDIPKAPEETIQSKKEDLPKSSEEAI------QPKEGDIPKSSAKPIQPKLGNIA 225

Query: 331 RTS---SEPEFNSLPR---KLLQPERRGPPRKFSQP-------EPSAVLKRHPQPEFFGD 377
           +TS   S+P+ + +P+   + +QP+    P+  ++P        P A +K  P     GD
Sbjct: 226 KTSVKPSQPKESDIPKSPEETIQPKEGDIPKSSAKPIQPKLGNIPKASVK--PSQPKEGD 283

Query: 378 LPRKPPLPSSASESSLPAAVAGFSSRHPLSPGFGAAGTPRWRSGGLVHSGGARP-GLRPS 436
           + + P       E  LP      S    + P  G    P+     +    G  P  L  +
Sbjct: 284 ISKSPEEAIQPKEGDLPK-----SLEEAIQPKEG--DIPKSPEEAIQPKEGDIPKSLEEA 336

Query: 437 HPPRRRPLPPASSLGHPPAKPPLPPGP---VDMQSFRRPSAASIDLRRTRSAAGLHFQDR 493
             P+   +P +      P K  +P  P   +  +    P +    ++          ++ 
Sbjct: 337 IQPKEGDIPKSPEETIQPKKGDIPKSPEEAIQPKEGDIPKSPKQAIQPKEGDIPKSLEEA 396

Query: 494 -QPEDIPVPDEIYELYDDVEPRDDSSPSPKGRDEA-PSVQQAARRPPQD 540
             P++I +P    E    ++P++D   SPK  +EA PS +    +P ++
Sbjct: 397 IPPKEIDIPKSPEE---TIQPKEDD--SPKSLEEATPSKEGDILKPEEE 440



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 34/122 (27%), Positives = 62/122 (50%), Gaps = 13/122 (10%)

Query: 19  KAKFQASQPEPSDLPKKPPK---PEFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPPPE 75
           K+  +A QP+  D+PK P +   P+ G + K   PE +  PK+  +P+    +++P   +
Sbjct: 331 KSLEEAIQPKEGDIPKSPEETIQPKKGDIPK--SPEEAIQPKEGDIPKSPKQAIQPKEGD 388

Query: 76  VTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPSK----LELSDLSKKF 131
           +    ++  PP+  D+PK    PE T  PK+   P+  +    PSK    L+  + + +F
Sbjct: 389 IPKSLEEAIPPKEIDIPKS---PEETIQPKEDDSPKSLE-EATPSKEGDILKPEEETMEF 444

Query: 132 PQ 133
           P+
Sbjct: 445 PE 446



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 61/320 (19%), Positives = 119/320 (37%), Gaps = 61/320 (19%)

Query: 256 KPQSSEPKRDSSAFPKKASQPPLSDFPKKPPQPELGDLTRTSSEPEVSVLPKRP------ 309
           + + S+  ++    PK ++    +  PK+   P+  + T    +P+   +PK P      
Sbjct: 76  RTEESDASQEGDDLPKSSAN---TSHPKQDDSPKSSEET---IQPKEGDIPKAPEETIQS 129

Query: 310 RPAEFKALSKKPPQPELGGLPRTSS---EPEFNSLPRKLLQPERRGPPRKFSQPEPSAVL 366
           +  +    S+K  QP+   +P++S+   +P+  ++P+  ++P +         PE +   
Sbjct: 130 KKEDLPKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQS 189

Query: 367 KRHPQPEFFGDLPRKPPLPSSASESSLPAAVAGFSSRHPLSPGFGAAGTPRWRSGGLVHS 426
           K+        DLP+         E  +P      SS  P+ P  G               
Sbjct: 190 KKE-------DLPKSSEEAIQPKEGDIPK-----SSAKPIQPKLGNI------------- 224

Query: 427 GGARPGLRPSHP--------PRRRPLPPASSLGHPPAKPPLPP-GPVDMQSFRRPSAASI 477
             A+  ++PS P        P     P    +    AKP  P  G +   S +       
Sbjct: 225 --AKTSVKPSQPKESDIPKSPEETIQPKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEG 282

Query: 478 DLRRTRSAAGLHFQDRQPEDIPVPDEIYELYD----DVEPRDDSSPSPKGRDEAPSVQQA 533
           D+ ++   A       QP++  +P  + E       D+    + +  PK  D   S+++A
Sbjct: 283 DISKSPEEA------IQPKEGDLPKSLEEAIQPKEGDIPKSPEEAIQPKEGDIPKSLEEA 336

Query: 534 ARRPPQDPALRKEKDPQPQQ 553
            +    D     E+  QP++
Sbjct: 337 IQPKEGDIPKSPEETIQPKK 356


>gi|42516570 thioredoxin domain-containing 2 isoform 1 [Homo
           sapiens]
          Length = 486

 Score =  103 bits (256), Expect = 7e-22
 Identities = 103/374 (27%), Positives = 170/374 (45%), Gaps = 64/374 (17%)

Query: 19  KAKFQASQPEPSDLPKKPPK---PEFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPPPE 75
           K+    S P+  D PK   +   P+ G + K   PE +   KK  LP+    +++P   +
Sbjct: 24  KSSANTSHPKQDDSPKSSEETIQPKEGDIPK--APEETIQSKKEDLPKSSEKAIQP---K 78

Query: 76  VTDLPK---KPPPPEVTDLPK---KPPPPEVTDLPKKPP---PPEVTDLPKKPSKLELSD 126
            +++PK   KP  P++ ++PK   KP  P+  D+PK P      +  DLPK  S+  +  
Sbjct: 79  ESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQSKKEDLPKS-SEEAIQP 137

Query: 127 LSKKFPQLGATPFPRKPLQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARPPS--EPK 184
                P+  A     KP+QP++G    K S+        KP QP E   P  P    +PK
Sbjct: 138 KEGDIPKSSA-----KPIQPKLGNI-AKTSV--------KPSQPKESDIPKSPEETIQPK 183

Query: 185 SGAFPR---KLWQPEAGEATPRSPQPELSTFPKKPAQPEFNVYPKKPPQPQVGGLPK--K 239
            G  P+   K  QP+ G        P+ S  P +P + + +  P++  QP+ G LPK  +
Sbjct: 184 EGDIPKSSAKPIQPKLGNI------PKASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLE 237

Query: 240 SVPQPEFSEAAQTPLWKPQSSEPKR-DSSAFPKKASQPPLSDFPKKPP---QPELGDLTR 295
              QP+  +  ++P    ++ +PK  D     ++A QP   D PK P    QP+ GD+ +
Sbjct: 238 EAIQPKEGDIPKSP---EEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGDIPK 294

Query: 296 TSSEPEVSVLPKRPRPAEFKALSKKPPQPELGGLPRTSSEP------EFNSLPRKLLQPE 349
           +   PE ++ PK     +     K+  QP+ G +P++  E       +    P + +QP+
Sbjct: 295 S---PEEAIQPKE---GDIPKSPKQAIQPKEGDIPKSLEEAIPPKEIDIPKSPEETIQPK 348

Query: 350 RRGPPRKFSQPEPS 363
               P+   +  PS
Sbjct: 349 EDDSPKSLEEATPS 362



 Score = 93.6 bits (231), Expect = 5e-19
 Identities = 94/334 (28%), Positives = 157/334 (47%), Gaps = 70/334 (20%)

Query: 17  SIKAKFQASQPEPSDLPKKPPKPEFGKLKKFSQPELSE---HPKKAPLPEFGA------- 66
           S K+  +  QP+  D+PK P   E  + KK   P+ SE    PK++ +P+  A       
Sbjct: 37  SPKSSEETIQPKEGDIPKAPE--ETIQSKKEDLPKSSEKAIQPKESNIPKSSAKPIQPKL 94

Query: 67  -----VSLKPPPPEVTDLPKKPP---PPEVTDLPKKPP---PPEVTDLPK---KPPPPEV 112
                 S+KP  P+  D+PK P      +  DLPK       P+  D+PK   KP  P++
Sbjct: 95  GNIPKASVKPSQPKEGDIPKAPEETIQSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKL 154

Query: 113 TDLPK---KPSKLELSDLSKKFPQLGATPFPRKPLQPEVGEAPLKASLPEPGAPARKPLQ 169
            ++ K   KPS+ + SD+ K          P + +QP+ G+ P  ++         KP+Q
Sbjct: 155 GNIAKTSVKPSQPKESDIPKS---------PEETIQPKEGDIPKSSA---------KPIQ 196

Query: 170 P--DELSHPARPPSEPKSGAF---PRKLWQPEAGEATPRSPQPELSTFPKKPAQPEFNVY 224
           P    +   +  PS+PK G     P +  QP+ G+  P+S +  +     +P + +    
Sbjct: 197 PKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGD-LPKSLEEAI-----QPKEGDIPKS 250

Query: 225 PKKPPQPQVGGLPK--KSVPQPEFSEAAQTPLWKPQSSEPKR-DSSAFPKKASQPPLSDF 281
           P++  QP+ G +PK  +   QP+  +  ++P    ++ +PK+ D    P++A QP   D 
Sbjct: 251 PEEAIQPKEGDIPKSLEEAIQPKEGDIPKSP---EETIQPKKGDIPKSPEEAIQPKEGDI 307

Query: 282 PKKPP---QPELGDLTRTSSE---PEVSVLPKRP 309
           PK P    QP+ GD+ ++  E   P+   +PK P
Sbjct: 308 PKSPKQAIQPKEGDIPKSLEEAIPPKEIDIPKSP 341



 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 94/350 (26%), Positives = 152/350 (43%), Gaps = 39/350 (11%)

Query: 75  EVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPSKLELSDLSKKFPQL 134
           E  DLPK             P   E T  PK+   P+  +   +  K +L   S+K  Q 
Sbjct: 18  EGDDLPKSSANTSHPKQDDSPKSSEETIQPKEGDIPKAPEETIQSKKEDLPKSSEKAIQP 77

Query: 135 GATPFPR---KPLQPEVGEAP---LKASLPEPGAPARKP-----LQPDELSHPARPPSEP 183
             +  P+   KP+QP++G  P   +K S P+ G   + P      + ++L   +    +P
Sbjct: 78  KESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQSKKEDLPKSSEEAIQP 137

Query: 184 KSGAFPR---KLWQPEAG---EATPRSPQPELSTFPKKP---AQPEFNVYPK---KPPQP 231
           K G  P+   K  QP+ G   + + +  QP+ S  PK P    QP+    PK   KP QP
Sbjct: 138 KEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETIQPKEGDIPKSSAKPIQP 197

Query: 232 QVGGLPKKSV--PQPEFSEAAQTPLWKPQSSEPKR-DSSAFPKKASQPPLSDFPKKPP-- 286
           ++G +PK SV   QP+  + +++P    ++ +PK  D     ++A QP   D PK P   
Sbjct: 198 KLGNIPKASVKPSQPKEGDISKSP---EEAIQPKEGDLPKSLEEAIQPKEGDIPKSPEEA 254

Query: 287 -QPELGDLTRTSSE---PEVSVLPKRPRPAEFKALSKKPPQPELGGLPRTSSEPEFNSLP 342
            QP+ GD+ ++  E   P+   +PK P           P  PE    P+    P+    P
Sbjct: 255 IQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGDIPKSPEEAIQPKEGDIPK---SP 311

Query: 343 RKLLQPERRGPPRKFSQPEPSAVLKRHPQPEFFGDLPRKPPLPSSASESS 392
           ++ +QP+    P+   +  P   +     PE     P++   P S  E++
Sbjct: 312 KQAIQPKEGDIPKSLEEAIPPKEIDIPKSPEETIQ-PKEDDSPKSLEEAT 360



 Score = 70.1 bits (170), Expect = 6e-12
 Identities = 97/409 (23%), Positives = 161/409 (39%), Gaps = 82/409 (20%)

Query: 157 LPEPGAPARKPLQPDELSHPARPPSEPKSGAFPRKLWQPEAGEATPRSPQPELSTFPKKP 216
           LP+  A    P Q D+    +    +PK G  P+      A E T +S + +L    +K 
Sbjct: 22  LPKSSANTSHPKQ-DDSPKSSEETIQPKEGDIPK------APEETIQSKKEDLPKSSEKA 74

Query: 217 AQPEFNVYPK---KPPQPQVGGLPKKSVPQPEFSEAAQTPLWKPQSSEPKRDSSAFPKKA 273
            QP+ +  PK   KP QP++G +PK SV                              K 
Sbjct: 75  IQPKESNIPKSSAKPIQPKLGNIPKASV------------------------------KP 104

Query: 274 SQPPLSDFPKKPP---QPELGDLTRTSSEPEVSVLPKRPRPAEFKALSKKPPQPELGGLP 330
           SQP   D PK P    Q +  DL ++S E        +P+  +    S KP QP+LG + 
Sbjct: 105 SQPKEGDIPKAPEETIQSKKEDLPKSSEEAI------QPKEGDIPKSSAKPIQPKLGNIA 158

Query: 331 RTS---SEPEFNSLPR---KLLQPERRGPPRKFSQP-------EPSAVLKRHPQPEFFGD 377
           +TS   S+P+ + +P+   + +QP+    P+  ++P        P A +K  P     GD
Sbjct: 159 KTSVKPSQPKESDIPKSPEETIQPKEGDIPKSSAKPIQPKLGNIPKASVK--PSQPKEGD 216

Query: 378 LPRKPPLPSSASESSLPAAVAGFSSRHPLSPGFGAAGTPRWRSGGLVHSGGARP-GLRPS 436
           + + P       E  LP      S    + P  G    P+     +    G  P  L  +
Sbjct: 217 ISKSPEEAIQPKEGDLPK-----SLEEAIQPKEG--DIPKSPEEAIQPKEGDIPKSLEEA 269

Query: 437 HPPRRRPLPPASSLGHPPAKPPLPPGP---VDMQSFRRPSAASIDLRRTRSAAGLHFQDR 493
             P+   +P +      P K  +P  P   +  +    P +    ++          ++ 
Sbjct: 270 IQPKEGDIPKSPEETIQPKKGDIPKSPEEAIQPKEGDIPKSPKQAIQPKEGDIPKSLEEA 329

Query: 494 -QPEDIPVPDEIYELYDDVEPRDDSSPSPKGRDEA-PSVQQAARRPPQD 540
             P++I +P    E    ++P++D   SPK  +EA PS +    +P ++
Sbjct: 330 IPPKEIDIPKSPEE---TIQPKEDD--SPKSLEEATPSKEGDILKPEEE 373



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 34/122 (27%), Positives = 62/122 (50%), Gaps = 13/122 (10%)

Query: 19  KAKFQASQPEPSDLPKKPPK---PEFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPPPE 75
           K+  +A QP+  D+PK P +   P+ G + K   PE +  PK+  +P+    +++P   +
Sbjct: 264 KSLEEAIQPKEGDIPKSPEETIQPKKGDIPK--SPEEAIQPKEGDIPKSPKQAIQPKEGD 321

Query: 76  VTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPSK----LELSDLSKKF 131
           +    ++  PP+  D+PK    PE T  PK+   P+  +    PSK    L+  + + +F
Sbjct: 322 IPKSLEEAIPPKEIDIPKS---PEETIQPKEDDSPKSLE-EATPSKEGDILKPEEETMEF 377

Query: 132 PQ 133
           P+
Sbjct: 378 PE 379



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 61/320 (19%), Positives = 119/320 (37%), Gaps = 61/320 (19%)

Query: 256 KPQSSEPKRDSSAFPKKASQPPLSDFPKKPPQPELGDLTRTSSEPEVSVLPKRP------ 309
           + + S+  ++    PK ++    +  PK+   P+  + T    +P+   +PK P      
Sbjct: 9   RTEESDASQEGDDLPKSSAN---TSHPKQDDSPKSSEET---IQPKEGDIPKAPEETIQS 62

Query: 310 RPAEFKALSKKPPQPELGGLPRTSS---EPEFNSLPRKLLQPERRGPPRKFSQPEPSAVL 366
           +  +    S+K  QP+   +P++S+   +P+  ++P+  ++P +         PE +   
Sbjct: 63  KKEDLPKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQS 122

Query: 367 KRHPQPEFFGDLPRKPPLPSSASESSLPAAVAGFSSRHPLSPGFGAAGTPRWRSGGLVHS 426
           K+        DLP+         E  +P      SS  P+ P  G               
Sbjct: 123 KKE-------DLPKSSEEAIQPKEGDIPK-----SSAKPIQPKLGNI------------- 157

Query: 427 GGARPGLRPSHP--------PRRRPLPPASSLGHPPAKPPLPP-GPVDMQSFRRPSAASI 477
             A+  ++PS P        P     P    +    AKP  P  G +   S +       
Sbjct: 158 --AKTSVKPSQPKESDIPKSPEETIQPKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEG 215

Query: 478 DLRRTRSAAGLHFQDRQPEDIPVPDEIYELYD----DVEPRDDSSPSPKGRDEAPSVQQA 533
           D+ ++   A       QP++  +P  + E       D+    + +  PK  D   S+++A
Sbjct: 216 DISKSPEEA------IQPKEGDLPKSLEEAIQPKEGDIPKSPEEAIQPKEGDIPKSLEEA 269

Query: 534 ARRPPQDPALRKEKDPQPQQ 553
            +    D     E+  QP++
Sbjct: 270 IQPKEGDIPKSPEETIQPKK 289


>gi|41281612 zinc finger protein 828 [Homo sapiens]
          Length = 812

 Score = 97.8 bits (242), Expect = 3e-20
 Identities = 145/518 (27%), Positives = 199/518 (38%), Gaps = 83/518 (16%)

Query: 73  PPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLP-KKPPPPEVTDLPKKPSKLELSDLSKKF 131
           P +  D PK     E TD  K PP PE   +P     P  +  L  +  KL  S LS + 
Sbjct: 88  PDKWNDKPKNQLNKE-TDPVKSPPLPEHQKIPCNSAEPKSIPALSMETQKLG-SVLSPES 145

Query: 132 PQLGATPFPRKPLQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARPPSEP-----KSG 186
           P+    P P  PL+P+   + +   L  P  P+ +P +P  +S P  P S P     K  
Sbjct: 146 PK----PTPLTPLEPQKPGSVVSPELQTP-LPSPEPSKPASVSSPEPPKSVPVCESQKLA 200

Query: 187 AFPRKLWQPEAGEATPRSPQPELSTF--PKKPAQPEFNVYPKKPPQPQVGGLPKKSVPQP 244
             P     PE  +  P SP+   +T   PK   Q  F         P+  G P  S P+ 
Sbjct: 201 PVP----SPEPQKPAPVSPESVKATLSNPKPQKQSHF---------PETLGPPSASSPES 247

Query: 245 EFSEAAQTPLWKPQSSEPKRDSSAFPKKASQPPLSDFPKKPPQPELGDLTRTSSEPEVSV 304
               A+  P     ++ P+   SA  +  S  P    P + P+P           P VS 
Sbjct: 248 PVLAASPEPWGPSPAASPESRKSA--RTTSPEPRKPSPSESPEP-------WKPFPAVSP 298

Query: 305 LPKRPRPAEFKALSKKPPQPELGGLPRT-SSEPEFNSLPRKLLQPERRGPPRKFSQPEPS 363
            P+RP PA     S KP  P   G PR   S P  +S P K  +P     P  + +P PS
Sbjct: 299 EPRRPAPAVSPG-SWKPGPP---GSPRPWKSNPSASSGPWKPAKPAPSVSPGPW-KPIPS 353

Query: 364 AVLKRHPQPEFFGDLPRKP-PLPSSASESSLPAAVAGFSSRHPLSPGFGAAGTPRWRSGG 422
                          P KP P  SSAS  S   + + + S  P SP    +G P  R   
Sbjct: 354 V-----------SPGPWKPTPSVSSASWKSSSVSPSSWKSP-PASPESWKSGPPELRKTA 401

Query: 423 LVHSGGARPGLRPSHPPRRRPLPPASSLGHPPAKPP---LPPGPVDMQSFRRPSAASIDL 479
              S      + P  P  R+P PP S     PA  P    P G  D+         S D 
Sbjct: 402 PTLSPEHWKAVPPVSPELRKPGPPLSPEIRSPAGSPELRKPSGSPDLWKL------SPDQ 455

Query: 480 RRTRSAAGLHFQDRQPEDIPVPDEIYELYDDVEPR-----DDSSPSPKGRDEAPSVQQAA 534
           R+T S A L F + Q        ++++    +EP+     +   P P G  E+P      
Sbjct: 456 RKT-SPASLDFPESQKSSRGGSPDLWKSSFFIEPQKPVFPETRKPGPSGPSESPKAASDI 514

Query: 535 RRP-------PQDPALRKEKDPQP-QQLPPMDPKLLKQ 564
            +P       P+ PAL     P+P +  PP  P+  K+
Sbjct: 515 WKPVLSIDTEPRKPAL----FPEPAKTAPPASPEARKR 548



 Score = 73.2 bits (178), Expect = 7e-13
 Identities = 112/420 (26%), Positives = 145/420 (34%), Gaps = 63/420 (15%)

Query: 30  SDLPKKPPKPEFGKL-----KKFSQPELS------------EHPKKAPLPEF------GA 66
           +D  K PP PE  K+     +  S P LS            E PK  PL           
Sbjct: 103 TDPVKSPPLPEHQKIPCNSAEPKSIPALSMETQKLGSVLSPESPKPTPLTPLEPQKPGSV 162

Query: 67  VSLKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPSKLELSD 126
           VS +   P  +  P KP      + PK  P  E   L   P P      P  P  ++ + 
Sbjct: 163 VSPELQTPLPSPEPSKPASVSSPEPPKSVPVCESQKLAPVPSPEPQKPAPVSPESVKATL 222

Query: 127 LSKKFPQLGATPFPRKPLQPEVGEAPLKASLPEP--GAPARKPLQPDELSHPARPPSEPK 184
            + K  +    P    P      E+P+ A+ PEP   +PA  P         +  P +P 
Sbjct: 223 SNPKPQKQSHFPETLGPPSASSPESPVLAASPEPWGPSPAASPESRKSARTTSPEPRKPS 282

Query: 185 SGAFPRKLWQP-EAGEATPRSPQPELSTFPKKPAQPEFNVYPKKPPQPQVGGLPKKSVPQ 243
               P   W+P  A    PR P P +S    KP  P  +  P K       G  K + P 
Sbjct: 283 PSESPEP-WKPFPAVSPEPRRPAPAVSPGSWKPGPPG-SPRPWKSNPSASSGPWKPAKPA 340

Query: 244 PEFSEAAQTPL-------WKPQ---SSEPKRDSSAFPKKASQPPLSDFPKKPPQPELGDL 293
           P  S     P+       WKP    SS   + SS  P     PP S    K   PEL   
Sbjct: 341 PSVSPGPWKPIPSVSPGPWKPTPSVSSASWKSSSVSPSSWKSPPASPESWKSGPPELRKT 400

Query: 294 TRTSSE------PEVSVLPKRPRPAEFKALSKKPPQPELGGLPRTSSEPEFNSLPRKLLQ 347
             T S       P VS   ++P P     +      PE   L + S  P+      KL  
Sbjct: 401 APTLSPEHWKAVPPVSPELRKPGPPLSPEIRSPAGSPE---LRKPSGSPDL----WKLSP 453

Query: 348 PERRGPPRKFSQPEPSAVLKRHPQPEF----FGDLPRKP-------PLPSSASESSLPAA 396
            +R+  P     PE S    R   P+     F   P+KP       P PS  SES   A+
Sbjct: 454 DQRKTSPASLDFPE-SQKSSRGGSPDLWKSSFFIEPQKPVFPETRKPGPSGPSESPKAAS 512



 Score = 29.6 bits (65), Expect = 9.4
 Identities = 30/83 (36%), Positives = 36/83 (43%), Gaps = 10/83 (12%)

Query: 92  PKKPPPPEVTDLPKKPPPPEVTDLPKKPS---KLELS-DLSKKFPQLGATPFPRKPLQPE 147
           P+KP  PE     +KP P   ++ PK  S   K  LS D   + P L   P P K   P 
Sbjct: 488 PQKPVFPET----RKPGPSGPSESPKAASDIWKPVLSIDTEPRKPAL--FPEPAKTAPPA 541

Query: 148 VGEAPLKASLPEPGAPARKPLQP 170
             EA  +A  PEP   A  P  P
Sbjct: 542 SPEARKRALFPEPRKHALFPELP 564


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 1124

 Score = 97.1 bits (240), Expect = 5e-20
 Identities = 134/509 (26%), Positives = 172/509 (33%), Gaps = 89/509 (17%)

Query: 1   MAHHLPAAMESHQDFRSIKAKFQASQPE------------PSDLPKKPPKPEFGKLKKFS 48
           +A H P A  S      ++ +   + P               +LP   P P        +
Sbjct: 495 LASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENLPSLAPPPLQTASAPLT 554

Query: 49  QPELSEHPKKAPLPEFGAVS-LKPPPPEVTDLPKKPPP--------PEVTDLPKKPPPPE 99
            P L   P  AP P     S L  PPPE       PPP        P +  LP  P  P 
Sbjct: 555 TPHLETPPCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALASPPLQGLPSPPLSPL 614

Query: 100 VTDLPKKPPP---PEVTDLPKKPSKLELSDLSKKFPQLGATPFPRKP--LQPEVGEAPLK 154
            T  P+ PP    P +   P  P+   LS L        ATP P+ P  L   + +AP  
Sbjct: 615 ATPPPQAPPXLALPPLQAPPSPPASPPLSPL--------ATPSPQAPNALAVHLLQAPFS 666

Query: 155 ASLPEPGAPARKPLQPDELSHPARPPSEPKSGAFPRKLWQPEAGEATPRSPQPELSTFPK 214
              P P  P + P  P     PA PP  P +             +A P    P L   P 
Sbjct: 667 ---PPPSPPVQAPFSP-----PASPPVSPSA---------TPPSQAPPSLAAPPLQVPPS 709

Query: 215 KPAQPEFNVYPKKPPQ--PQVGGLPKKSVPQPEFSEAAQTPLWKPQSSEPKRDSSAFPKK 272
            PA P  +     PPQ  P +   P +  P P  S     P   P ++ P R     P  
Sbjct: 710 PPASPPMSPSATPPPQAPPPLAAPPLQVPPSPPAS-----PPMSPSATPPPR----VPPL 760

Query: 273 ASQPPLSDFPKKPPQPELGDLTRTSSE-------PEVSVLPKRPRPAEFKALSKKPPQPE 325
            + PPL   P  P    +  L +   +       P +  LP    PA F   +   P   
Sbjct: 761 LAAPPLQVPPSPPASLPMSPLAKPPPQAPPALATPPLQALPS--PPASFPGQAPFSPSAS 818

Query: 326 LGGLPRTSSEPEFNSLPRKLLQPERRGPPRKFSQPEPSAVLKRHPQPE----------FF 375
           L   P  +  P+    P  L  P  + PP   + P   A  +R P P             
Sbjct: 819 LPMSPLATPPPQ---APPVLAAPLLQVPPSPPASPTLQAP-RRPPTPGPDTSVSGPRLTL 874

Query: 376 GDLPRKPPLPSSASESSLPAA-VAGFSSRHPLSPGFGAAGTPRWRSGGLVHSGGARPGLR 434
              P  PP PS +  S+L    +AG SS    +P     G      GG   S      L 
Sbjct: 875 ALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPE-ELRGYDSGPEGGAAASPPPDAELA 933

Query: 435 PSHPP--RRRPLPPASSLGHPPAKPPLPP 461
             HP    R P PP +  G P A  P PP
Sbjct: 934 ACHPAAWSRGPAPPLAFRGAPGAPLPWPP 962



 Score = 87.4 bits (215), Expect = 4e-17
 Identities = 158/592 (26%), Positives = 205/592 (34%), Gaps = 127/592 (21%)

Query: 19  KAKFQASQPEPSDL----------PKKPPKPEFGKLKKFSQPELSEHP-----KKAPLPE 63
           +A    SQP+P  L          P+K   P  G L   S P  +  P     +  P P+
Sbjct: 264 RAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLS--SSPLATPSPSGTKARPVPPPD 321

Query: 64  FGAV----SLKPPPPEVTDLPKKPP----PPEVTDLPKKP------PPPEVTDLPKKPPP 109
             A     +L P PP  T LP  PP    PP +  LP  P       PP +T  P + PP
Sbjct: 322 NAATPLPATLPPSPPLATPLPLAPPSPSAPPSLQTLPSPPATPPSQAPPSMTTPPMQAPP 381

Query: 110 PEVT-------------DLPKKPSKLELSDLSKKFPQLGATPFPRKPLQPEVGEAPLKAS 156
              T              L   PS L LS L +    LG+           +     +AS
Sbjct: 382 SLQTIPPIQVPHSLTSPSLQAPPSPLALSSL-QATTSLGSPTLQATHSFLTMSPRQTQAS 440

Query: 157 LPEPGAPARKPLQPDELSHPARPPSEPKSGAFPRKLWQPEAGEATPRSPQPELSTFPK-K 215
           L  P  PA  P        P  PP               +A  + P SP  + S  P   
Sbjct: 441 LTSPSRPASTP--------PDSPPL--------------QAPLSLPASPPLQTSLSPAVS 478

Query: 216 PAQPEFNVYPKKPPQPQVGGLPKKSVPQPEFSEAAQTPLWKPQSSEPKRDSSAFPKKASQ 275
           P      ++P +     +  L   S PQ   S     PL + QSS         P   + 
Sbjct: 479 PLSSPLTIHPLQ----ALSSLASHS-PQAPLSSLIMPPL-ETQSSLAPPSLQTPPASLTT 532

Query: 276 PPLSDFPKKPPQPELGDLTRTSSEPEVS---VLPKRPRPAEFKALSKKPPQPELGGLPRT 332
           PPL + P   P P      +T+S P  +     P  P P   +A    PP       P T
Sbjct: 533 PPLENLPSLAPPP-----LQTASAPLTTPHLETPPCPAPCPLQA----PPS------PLT 577

Query: 333 SSEPEFNSLPRKLLQPERRGPPRKFSQPEPSAVLKRHPQPEFFGDLPRKPPLPSSASESS 392
           +  PE    P  +  P  + PP   S P     L+  P P      P   P P +    +
Sbjct: 578 TPPPE---TPSSIATPPPQAPPALASPP-----LQGLPSPPL---SPLATPPPQAPPXLA 626

Query: 393 LPAAVAGFS--SRHPLSPGFGAAGTPRWRSGGLVHSGGARPGLRPSHPPRRRPLPPASSL 450
           LP   A  S  +  PLSP   A  +P+  +   VH   A     P  PP   P PP  + 
Sbjct: 627 LPPLQAPPSPPASPPLSP--LATPSPQAPNALAVHLLQA-----PFSPP---PSPPVQAP 676

Query: 451 GHPPAKPPLPPGPVDMQSFRRPSAASIDLRRTRSAAGLHFQDRQPEDIPVPDEIYELYDD 510
             PPA PP+ P      S   PS A+  L+   S          P   P P     L   
Sbjct: 677 FSPPASPPVSPSATP-PSQAPPSLAAPPLQVPPSPPA--SPPMSPSATPPPQAPPPL--- 730

Query: 511 VEPRDDSSPSPKGRDEAPSVQQAARRPPQDPALRKEKDPQPQQLPPMDPKLL 562
             P     PSP     +P +  +A  PP+ P L       P Q+PP  P  L
Sbjct: 731 AAPPLQVPPSPPA---SPPMSPSATPPPRVPPLLA---APPLQVPPSPPASL 776



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 103/414 (24%), Positives = 131/414 (31%), Gaps = 73/414 (17%)

Query: 184 KSGAFPRKLWQPEAGEATPRSPQPELSTFPKKPAQPEF----NVYPKKPPQPQVGGLP-- 237
           K+GA  R       G  TPR P       P  PA            +KP   + GG+   
Sbjct: 9   KAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGA 68

Query: 238 --KKSVPQPEFSEAAQTPLWKPQSSEPK--RDSSAFPKKASQPPLSDFPKKP-----PQP 288
              +S P+   + +A T    P S  P   R   A P K + P     P +      P P
Sbjct: 69  TIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGP 128

Query: 289 ELGDLTRTSSEPEVSVLPKRPRPAEFKALSKKPPQPELGGLPRTSSEPEFN--------- 339
            LG      S  E     K     +  ALS    +   G  P T S              
Sbjct: 129 -LGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEV 187

Query: 340 SLPRKLLQPERRGP---PRK-------FSQPEPSAVLKRHPQPEFFGDLPRKPPLPSSAS 389
            LPR       R P   PRK        S  EPS   +R P     G L R  P   S S
Sbjct: 188 GLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAG--GGLQR--PASRSLS 243

Query: 390 ESSLPAAVAGFSSRHPLSPGFGAAGTPRWRSGGLVHSGGARP----GLRPSH--PPRRRP 443
            S+ P +        P   G  A GTPR       H    +P     LRP    PPR+  
Sbjct: 244 SSATPLS-------SPARSGPSARGTPR----APAHPSQPKPKGLQALRPPQVTPPRKDA 292

Query: 444 LPPASSLGHPPAKPPLPPGPVDMQSFRRPSAASIDLRRTRSAAGLHFQDRQPEDIPVPDE 503
            P    L   P   P P G    +    P  A+  L  T            P   P+P  
Sbjct: 293 APALGPLSSSPLATPSPSG-TKARPVPPPDNAATPLPAT-------LPPSPPLATPLP-- 342

Query: 504 IYELYDDVEPRDDSSPSPKGRDEAPSVQQAARRPPQDPALRKEKDPQPQQLPPM 557
                  + P   S+P       +P     ++ PP       +  P  Q +PP+
Sbjct: 343 -------LAPPSPSAPPSLQTLPSPPATPPSQAPPSMTTPPMQAPPSLQTIPPI 389


>gi|40788007 FYN binding protein (FYB-120/130) isoform 2 [Homo
           sapiens]
          Length = 783

 Score = 93.6 bits (231), Expect = 5e-19
 Identities = 159/617 (25%), Positives = 222/617 (35%), Gaps = 123/617 (19%)

Query: 96  PPPEVTDLPK--KPPPPEVTDLPKKPSKLELSDLSKKFPQLGATPFPRKPLQPEVGEAPL 153
           PP   +++PK   P PP       KPS  E  D   K P L  T   ++   P    A L
Sbjct: 47  PPAGPSNVPKFGSPKPPVAV----KPSSEEKPDKEPKPPFLKPTGAGQRFGTP----ASL 98

Query: 154 KASLPEPGAPARKPLQPDELSHPARPPSEPKSGAFPRKLWQPEAGEATPRSPQPELSTFP 213
               PE      KP+ P     P   P E     FP   W P          +P L +  
Sbjct: 99  TTRDPEAKVGFLKPVGPK----PINLPKEDSKPTFP---WPP--------GNKPSLHSVN 143

Query: 214 K----KPAQPEFNVYPKKPPQPQVGGLPKKSVPQPEFSEAAQTPLWKPQSSEPKRDSSAF 269
           +    KP  P+    P      Q    PK +  + +F  A+Q         EPK     F
Sbjct: 144 QDHDLKPLGPKSGPTPPTSENEQKQAFPKLTGVKGKFMSASQ-------DLEPK---PLF 193

Query: 270 PKKASQPPLSDFPKKPPQPELGDLTRTSSEPEVSVLPKRPRPAEFKALSKKPP-QPELGG 328
           PK A       F +KPP     + +     P  +V   +  PA     SK  P +P    
Sbjct: 194 PKPA-------FGQKPPLST--ENSHEDESPMKNVSSSKGSPAPLGVRSKSGPLKPARED 244

Query: 329 LPRTSSEPEFNSLPRK--LLQP--ERRGPPRKFSQPEPSAVLKRHPQPEFFGDLPRKPPL 384
                   E +SLP    +L+P   R GP    +  E     K       F     +  L
Sbjct: 245 SENKDHAGEISSLPFPGVVLKPAASRGGPGLSKNGEEKKEDRKIDAAKNTFQSKINQEEL 304

Query: 385 PSSASESSLPAAVAGFSSRHPLSPGFGAAGTPRWRSGGLVHSGGARPGLRPSHPPRRRPL 444
            S    +           R P +P     G P W       S     G + S  P+++PL
Sbjct: 305 ASGTPPA-----------RFPKAPSKLTVGGP-WGQ-----SQEKEKGDKNSATPKQKPL 347

Query: 445 PPASSLGHPPAKPPLPPGPVDMQSFRRPSAASIDLRRTRS--------------AAGLHF 490
           PP  +LG PP KP  PP  VD+  F + S+ +   +   S              A+    
Sbjct: 348 PPLFTLGPPPPKPNRPPN-VDLTKFHKTSSGNSTSKGQTSYSTTSLPPPPPSHPASQPPL 406

Query: 491 QDRQPEDIPVPD-------EIYELYDDV-EPRDDSSPSPKGRDEAPSVQQAARRPPQDPA 542
               P   PVP          ++L   V E   D      G       Q +     +D  
Sbjct: 407 PASHPSQPPVPSLPPRNIKPPFDLKSPVNEDNQDGVTHSDGAGNLDEEQDSEGETYEDIE 466

Query: 543 LRKEKDPQPQQLPPMDPKL-LKQLRKAEKAEREFRKKFKFEGEI-VVH-TKMMIDPNAKT 599
             KE++ + ++      +L  K+ ++ EK E+E +KKFK  G I V+H  K   D     
Sbjct: 467 ASKEREKKREKEEKKRLELEKKEQKEKEKKEQEIKKKFKLTGPIQVIHLAKACCDV---- 522

Query: 600 RRGGGKHLGIRRGEILEVIEFTSNEE--MLCRDPKGKYGYVPRTAL-------------- 643
            +GG   L  ++GE +E+I  T N E   L R  +G YGY+  TA+              
Sbjct: 523 -KGGKNELSFKQGEQIEIIRITDNPEGKWLGRTARGSYGYIKTTAVEIDYDSLKLKKDSL 581

Query: 644 ----LPLE--TEVYDDV 654
                P+E   EVYDDV
Sbjct: 582 GAPSRPIEDDQEVYDDV 598



 Score = 90.9 bits (224), Expect = 3e-18
 Identities = 55/162 (33%), Positives = 90/162 (55%), Gaps = 11/162 (6%)

Query: 499 PVPDEIYELYDDVEPRD--DSSPSPKGR----DEAPSVQQAARRPPQDPALRKEKDPQPQ 552
           P PD+  ++YD +E  D  D  P+P  +    DE       +  P     + +  +    
Sbjct: 618 PPPDD--DIYDGIEEEDADDGFPAPPKQLDMGDEVYDDVDTSDFPVSSAEMSQGTNVGKA 675

Query: 553 QLPPMDPKLLKQLRKAEKAEREFRKKFKFEGEIVVHTKMMIDPNAKTRRGGGKHLGIRRG 612
           +    D   LK+L+K EK E++FRKKFK++GEI V     +  +  +++ G + L ++ G
Sbjct: 676 KTEEKD---LKKLKKQEKEEKDFRKKFKYDGEIRVLYSTKVTTSITSKKWGTRDLQVKPG 732

Query: 613 EILEVIEFTSNEEMLCRDPKGKYGYVPRTALLPLETEVYDDV 654
           E LEVI+ T + ++LCR+ +GKYGYV R+ L   + E+YDD+
Sbjct: 733 ESLEVIQTTDDTKVLCRNEEGKYGYVLRSYLADNDGEIYDDI 774



 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 96/374 (25%), Positives = 130/374 (34%), Gaps = 42/374 (11%)

Query: 24  ASQPEPSDLPKKPPKPEFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPPPEVTDLPKKP 83
           A +P   + P K PKP F K     Q   +        PE     LKP  P+  +LPK+ 
Sbjct: 65  AVKPSSEEKPDKEPKPPFLKPTGAGQRFGTPASLTTRDPEAKVGFLKPVGPKPINLPKED 124

Query: 84  PPPEVTDLP-KKPPPPEVT---DL----PKKPPPPEVTDLPKKPSKLELSDLSKKFPQLG 135
             P     P  KP    V    DL    PK  P P  ++  +K +  +L+ +  KF    
Sbjct: 125 SKPTFPWPPGNKPSLHSVNQDHDLKPLGPKSGPTPPTSENEQKQAFPKLTGVKGKFMSAS 184

Query: 136 ATPFPRKPLQPEVG---------------EAPLKASLPEPGAPARKPLQPDELS---HPA 177
               P KPL P+                 E+P+K      G+PA  PL     S    PA
Sbjct: 185 QDLEP-KPLFPKPAFGQKPPLSTENSHEDESPMKNVSSSKGSPA--PLGVRSKSGPLKPA 241

Query: 178 RPPSEPKSGA-------FPRKLWQPEAGEATPRSPQPELSTFPKKPAQPEFNVYPKKPPQ 230
           R  SE K  A       FP  + +P A    P   +        +      N +  K  Q
Sbjct: 242 REDSENKDHAGEISSLPFPGVVLKPAASRGGPGLSKNGEEKKEDRKIDAAKNTFQSKINQ 301

Query: 231 PQV-GGLPKKSVPQPEFSEAAQTPLWKPQSSEPKRDSSAFPKKASQPPLSDF---PKKPP 286
            ++  G P    P+         P  + Q  E    +SA PK+   PPL      P KP 
Sbjct: 302 EELASGTPPARFPKAPSKLTVGGPWGQSQEKEKGDKNSATPKQKPLPPLFTLGPPPPKPN 361

Query: 287 QPELGDLTRTSSEPEVSVLPKRPRPAEFKALSKKPPQPELGGLPRTSSEPEFNSLPRKLL 346
           +P   DLT+       +   K        +L   PP       P  +S P    +P   L
Sbjct: 362 RPPNVDLTKFHKTSSGNSTSKGQTSYSTTSLPPPPPSHPASQPPLPASHPSQPPVPS--L 419

Query: 347 QPERRGPPRKFSQP 360
            P    PP     P
Sbjct: 420 PPRNIKPPFDLKSP 433



 Score = 35.4 bits (80), Expect = 0.17
 Identities = 39/151 (25%), Positives = 52/151 (34%), Gaps = 23/151 (15%)

Query: 46  KFSQPELSEHPKKAPLPE----------FGAVSLKPPPPEVTDLPKKPPPPEVTDLPKKP 95
           K +Q EL+     A  P+          +G    K    + +  PK+ P P +  L   P
Sbjct: 298 KINQEELASGTPPARFPKAPSKLTVGGPWGQSQEKEKGDKNSATPKQKPLPPLFTLG--P 355

Query: 96  PPPEVTDLPKKPPPPEVTDLPKKPSKLELSDLSKKFPQLGATPFPRKPLQPEVGEAPLKA 155
           PPP       KP  P   DL K       +  SK       T  P  P      + PL A
Sbjct: 356 PPP-------KPNRPPNVDLTKFHKTSSGNSTSKGQTSYSTTSLPPPPPSHPASQPPLPA 408

Query: 156 SLPE----PGAPARKPLQPDELSHPARPPSE 182
           S P     P  P R    P +L  P    ++
Sbjct: 409 SHPSQPPVPSLPPRNIKPPFDLKSPVNEDNQ 439


>gi|42476118 FYN binding protein (FYB-120/130) isoform 1 [Homo
           sapiens]
          Length = 829

 Score = 93.6 bits (231), Expect = 5e-19
 Identities = 159/617 (25%), Positives = 222/617 (35%), Gaps = 123/617 (19%)

Query: 96  PPPEVTDLPK--KPPPPEVTDLPKKPSKLELSDLSKKFPQLGATPFPRKPLQPEVGEAPL 153
           PP   +++PK   P PP       KPS  E  D   K P L  T   ++   P    A L
Sbjct: 47  PPAGPSNVPKFGSPKPPVAV----KPSSEEKPDKEPKPPFLKPTGAGQRFGTP----ASL 98

Query: 154 KASLPEPGAPARKPLQPDELSHPARPPSEPKSGAFPRKLWQPEAGEATPRSPQPELSTFP 213
               PE      KP+ P     P   P E     FP   W P          +P L +  
Sbjct: 99  TTRDPEAKVGFLKPVGPK----PINLPKEDSKPTFP---WPP--------GNKPSLHSVN 143

Query: 214 K----KPAQPEFNVYPKKPPQPQVGGLPKKSVPQPEFSEAAQTPLWKPQSSEPKRDSSAF 269
           +    KP  P+    P      Q    PK +  + +F  A+Q         EPK     F
Sbjct: 144 QDHDLKPLGPKSGPTPPTSENEQKQAFPKLTGVKGKFMSASQ-------DLEPK---PLF 193

Query: 270 PKKASQPPLSDFPKKPPQPELGDLTRTSSEPEVSVLPKRPRPAEFKALSKKPP-QPELGG 328
           PK A       F +KPP     + +     P  +V   +  PA     SK  P +P    
Sbjct: 194 PKPA-------FGQKPPLST--ENSHEDESPMKNVSSSKGSPAPLGVRSKSGPLKPARED 244

Query: 329 LPRTSSEPEFNSLPRK--LLQP--ERRGPPRKFSQPEPSAVLKRHPQPEFFGDLPRKPPL 384
                   E +SLP    +L+P   R GP    +  E     K       F     +  L
Sbjct: 245 SENKDHAGEISSLPFPGVVLKPAASRGGPGLSKNGEEKKEDRKIDAAKNTFQSKINQEEL 304

Query: 385 PSSASESSLPAAVAGFSSRHPLSPGFGAAGTPRWRSGGLVHSGGARPGLRPSHPPRRRPL 444
            S    +           R P +P     G P W       S     G + S  P+++PL
Sbjct: 305 ASGTPPA-----------RFPKAPSKLTVGGP-WGQ-----SQEKEKGDKNSATPKQKPL 347

Query: 445 PPASSLGHPPAKPPLPPGPVDMQSFRRPSAASIDLRRTRS--------------AAGLHF 490
           PP  +LG PP KP  PP  VD+  F + S+ +   +   S              A+    
Sbjct: 348 PPLFTLGPPPPKPNRPPN-VDLTKFHKTSSGNSTSKGQTSYSTTSLPPPPPSHPASQPPL 406

Query: 491 QDRQPEDIPVPD-------EIYELYDDV-EPRDDSSPSPKGRDEAPSVQQAARRPPQDPA 542
               P   PVP          ++L   V E   D      G       Q +     +D  
Sbjct: 407 PASHPSQPPVPSLPPRNIKPPFDLKSPVNEDNQDGVTHSDGAGNLDEEQDSEGETYEDIE 466

Query: 543 LRKEKDPQPQQLPPMDPKL-LKQLRKAEKAEREFRKKFKFEGEI-VVH-TKMMIDPNAKT 599
             KE++ + ++      +L  K+ ++ EK E+E +KKFK  G I V+H  K   D     
Sbjct: 467 ASKEREKKREKEEKKRLELEKKEQKEKEKKEQEIKKKFKLTGPIQVIHLAKACCDV---- 522

Query: 600 RRGGGKHLGIRRGEILEVIEFTSNEE--MLCRDPKGKYGYVPRTAL-------------- 643
            +GG   L  ++GE +E+I  T N E   L R  +G YGY+  TA+              
Sbjct: 523 -KGGKNELSFKQGEQIEIIRITDNPEGKWLGRTARGSYGYIKTTAVEIDYDSLKLKKDSL 581

Query: 644 ----LPLE--TEVYDDV 654
                P+E   EVYDDV
Sbjct: 582 GAPSRPIEDDQEVYDDV 598



 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 56/160 (35%), Positives = 87/160 (54%), Gaps = 26/160 (16%)

Query: 495 PEDIPVPDEIYELYDDVEPRDDSSPSPKGRDEAPSVQQAARRPPQDPALRKEKDPQPQQL 554
           P+ + + DE+Y   DDV    D+S  P    E        +      A  +EKD      
Sbjct: 687 PKQLDMGDEVY---DDV----DTSDFPVSSAEMSQGTNVGK------AKTEEKD------ 727

Query: 555 PPMDPKLLKQLRKAEKAEREFRKKFKFEGEIVVHTKMMIDPNAKTRRGGGKHLGIRRGEI 614
                  LK+L+K EK E++FRKKFK++GEI V     +  +  +++ G + L ++ GE 
Sbjct: 728 -------LKKLKKQEKEEKDFRKKFKYDGEIRVLYSTKVTTSITSKKWGTRDLQVKPGES 780

Query: 615 LEVIEFTSNEEMLCRDPKGKYGYVPRTALLPLETEVYDDV 654
           LEVI+ T + ++LCR+ +GKYGYV R+ L   + E+YDD+
Sbjct: 781 LEVIQTTDDTKVLCRNEEGKYGYVLRSYLADNDGEIYDDI 820



 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 96/374 (25%), Positives = 130/374 (34%), Gaps = 42/374 (11%)

Query: 24  ASQPEPSDLPKKPPKPEFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPPPEVTDLPKKP 83
           A +P   + P K PKP F K     Q   +        PE     LKP  P+  +LPK+ 
Sbjct: 65  AVKPSSEEKPDKEPKPPFLKPTGAGQRFGTPASLTTRDPEAKVGFLKPVGPKPINLPKED 124

Query: 84  PPPEVTDLP-KKPPPPEVT---DL----PKKPPPPEVTDLPKKPSKLELSDLSKKFPQLG 135
             P     P  KP    V    DL    PK  P P  ++  +K +  +L+ +  KF    
Sbjct: 125 SKPTFPWPPGNKPSLHSVNQDHDLKPLGPKSGPTPPTSENEQKQAFPKLTGVKGKFMSAS 184

Query: 136 ATPFPRKPLQPEVG---------------EAPLKASLPEPGAPARKPLQPDELS---HPA 177
               P KPL P+                 E+P+K      G+PA  PL     S    PA
Sbjct: 185 QDLEP-KPLFPKPAFGQKPPLSTENSHEDESPMKNVSSSKGSPA--PLGVRSKSGPLKPA 241

Query: 178 RPPSEPKSGA-------FPRKLWQPEAGEATPRSPQPELSTFPKKPAQPEFNVYPKKPPQ 230
           R  SE K  A       FP  + +P A    P   +        +      N +  K  Q
Sbjct: 242 REDSENKDHAGEISSLPFPGVVLKPAASRGGPGLSKNGEEKKEDRKIDAAKNTFQSKINQ 301

Query: 231 PQV-GGLPKKSVPQPEFSEAAQTPLWKPQSSEPKRDSSAFPKKASQPPLSDF---PKKPP 286
            ++  G P    P+         P  + Q  E    +SA PK+   PPL      P KP 
Sbjct: 302 EELASGTPPARFPKAPSKLTVGGPWGQSQEKEKGDKNSATPKQKPLPPLFTLGPPPPKPN 361

Query: 287 QPELGDLTRTSSEPEVSVLPKRPRPAEFKALSKKPPQPELGGLPRTSSEPEFNSLPRKLL 346
           +P   DLT+       +   K        +L   PP       P  +S P    +P   L
Sbjct: 362 RPPNVDLTKFHKTSSGNSTSKGQTSYSTTSLPPPPPSHPASQPPLPASHPSQPPVPS--L 419

Query: 347 QPERRGPPRKFSQP 360
            P    PP     P
Sbjct: 420 PPRNIKPPFDLKSP 433



 Score = 35.4 bits (80), Expect = 0.17
 Identities = 39/151 (25%), Positives = 52/151 (34%), Gaps = 23/151 (15%)

Query: 46  KFSQPELSEHPKKAPLPE----------FGAVSLKPPPPEVTDLPKKPPPPEVTDLPKKP 95
           K +Q EL+     A  P+          +G    K    + +  PK+ P P +  L   P
Sbjct: 298 KINQEELASGTPPARFPKAPSKLTVGGPWGQSQEKEKGDKNSATPKQKPLPPLFTLG--P 355

Query: 96  PPPEVTDLPKKPPPPEVTDLPKKPSKLELSDLSKKFPQLGATPFPRKPLQPEVGEAPLKA 155
           PPP       KP  P   DL K       +  SK       T  P  P      + PL A
Sbjct: 356 PPP-------KPNRPPNVDLTKFHKTSSGNSTSKGQTSYSTTSLPPPPPSHPASQPPLPA 408

Query: 156 SLPE----PGAPARKPLQPDELSHPARPPSE 182
           S P     P  P R    P +L  P    ++
Sbjct: 409 SHPSQPPVPSLPPRNIKPPFDLKSPVNEDNQ 439


>gi|47132519 Ras association and pleckstrin homology domains 1 isoform
            1 [Homo sapiens]
          Length = 1250

 Score = 93.2 bits (230), Expect = 7e-19
 Identities = 126/481 (26%), Positives = 170/481 (35%), Gaps = 100/481 (20%)

Query: 6    PAAMESHQDFRSIKAKFQASQPEPSDLPKKPPKPEFGKLKKFSQPELSEHPKKAPLPEFG 65
            P  M+S      I        P P   P  PP P  G     +  +L   P    LP+F 
Sbjct: 689  PPVMQSQSVKPQILVPPNGVVPPP---PPPPPPPTPGS----AMAQLKPAPCAPSLPQFS 741

Query: 66   AVSLKPPPP----EVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPSK 121
            A    PPPP    +V  + +  PP      P  PPP      P+ PP P VT      +K
Sbjct: 742  A----PPPPLKIHQVQHITQVAPPT-----PPPPPPIPAPLPPQAPPKPLVTIPAPTSTK 792

Query: 122  LELSDLSKKFPQLGATPFPRKPLQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARPPS 181
                 +++  P     P P    QP    + +  S P P  P   P  P + S  A+PP 
Sbjct: 793  TVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFCAKPPP 852

Query: 182  EPKSGAFPRKLWQPEAGEATPRSPQPELSTFPKKPAQPEFNVYPKKPPQPQVGGLPK--- 238
             P S   P  + Q  +    P +P P + + P KP     NV P+ P  P V   PK   
Sbjct: 853  SPLS-PVPSVVKQIASQFPPPPTP-PAMESQPLKPVPA--NVAPQSP--PAVKAKPKWQP 906

Query: 239  KSVPQPEFSEAAQTPLWKPQSSEPKRDSSAFPKKASQPPLSDFPKKPPQPELGDLTRTSS 298
             S+P P       +P + P    P   S  FP     PP S  P  PP P        S 
Sbjct: 907  SSIPVP-------SPDFPP---PPPESSLVFP----PPPPSPVPAPPPPPP----PTASP 948

Query: 299  EPEVSVLP-KRPRPAEFKALSKKPPQPELGGLPRTSS--------EPEFNSLPRKLLQPE 349
             P+ S  P K+          K PP P+     ++SS         P  +SL  K   P 
Sbjct: 949  TPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPA 1008

Query: 350  RRGPPRKFSQPEPSAVLKRHPQPEFFGDLPRKPPLPSSASES--SLPAAV--AGFSSRHP 405
              G P K + P P+A                 PP P   + S  +LP  +     S++ P
Sbjct: 1009 ESGSPSKETLPPPAA-----------------PPKPGKLNLSGVNLPGVLQQGCVSAKAP 1051

Query: 406  LSPGFGAAGTPRWRSGGLVHSGGARPGLRPSHPPRRRPLPPASSLGHPPAKPPLPPGPVD 465
            +  G G      + S                 PP     PP      PP +  LP  P++
Sbjct: 1052 VLSGRGKDSVVEFPS-----------------PPSDSDFPP------PPPETELPLPPIE 1088

Query: 466  M 466
            +
Sbjct: 1089 I 1089



 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 138/543 (25%), Positives = 184/543 (33%), Gaps = 144/543 (26%)

Query: 17   SIKAKFQA-SQPEPSDLPKKPPKPEFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPPPE 75
            S KA+ ++ ++P  S +P   P+P+       SQP         PLP        PPPP 
Sbjct: 590  SSKARMESMNRPYTSLVPPLSPQPKIVTPYTASQPS-------PPLP--------PPPP- 633

Query: 76   VTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLP------------------- 116
                   PPPP     P  PPPP    LP +  P   +  P                   
Sbjct: 634  -------PPPP-----PPPPPPPPPPPLPSQSAPSAGSAAPMFVKYSTITRLQNASQHSG 681

Query: 117  ---KKPSKLELSDLSKK----FPQLGATPFPRKPLQP--------EVGEAPLKASLPEPG 161
               K P+   +   S K     P  G  P P  P  P        ++  AP   SLP+  
Sbjct: 682  ALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPGSAMAQLKPAPCAPSLPQFS 741

Query: 162  APARKPLQPDELSH------PARPPSEPKSGAFP----------------RKLWQPEAGE 199
            AP   PL+  ++ H      P  PP  P     P                 K   P   +
Sbjct: 742  APP-PPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQ 800

Query: 200  ATPRSPQPELSTFPKKPAQPEFNVYPKKPPQPQVGGLPKKSVPQPEFSEAAQTPLWKPQS 259
            A P +P P +    K+PA P  +  P  PP P V   P     Q  F          P  
Sbjct: 801  AAPPTPTPPVPPAKKQPAFPA-SYIPPSPPTPPVPVPPPTLPKQQSFCAKPPPSPLSPVP 859

Query: 260  SEPKRDSSAFPKKASQP----------PLSDFPKKPPQPELGDLTRTSSEPEVSVLPKRP 309
            S  K+ +S FP   + P          P +  P+ PP  +     + SS P  S  P  P
Sbjct: 860  SVVKQIASQFPPPPTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPS--PDFP 917

Query: 310  RPAEFKALSKKPPQPELGGLPRTSSEPEFNSLPRKLLQPERR-----GPPRKFSQPEP-- 362
             P    +L   PP P     P     P  +  P K   P ++      P  K   P P  
Sbjct: 918  PPPPESSLVFPPPPPSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQR 977

Query: 363  -----SAVLKRHPQPEFFGDLPRKPPLPSSASESSLPAAVAGFSSRHPLSPGFGAAGTPR 417
                 S+    HP+       P++P + S  S+ + P A +G  S+  L P    A  P 
Sbjct: 978  NSSIKSSSGAEHPE-------PKRPSVDSLVSKFT-PPAESGSPSKETLPP---PAAPP- 1025

Query: 418  WRSGGLVHSGGARPGL---------------RPSHPPRRRPLPPASSLGHPPAKP----P 458
             + G L  SG   PG+               R        P PP+ S   PP  P    P
Sbjct: 1026 -KPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGKDSVVEFPSPPSDS-DFPPPPPETELP 1083

Query: 459  LPP 461
            LPP
Sbjct: 1084 LPP 1086



 Score = 56.6 bits (135), Expect = 7e-08
 Identities = 90/363 (24%), Positives = 130/363 (35%), Gaps = 61/363 (16%)

Query: 234 GGLPKKSVPQPEFSEAAQTPLWKPQSSEPKRDSSAFPKKASQPPLSDFPKKPPQPELGDL 293
           G +  +S+    FSEA +      +SS+ + +S   P  +  PPLS      PQP++   
Sbjct: 565 GHVRSQSIVSSVFSEAWKRGTQLEESSKARMESMNRPYTSLVPPLS------PQPKI-VT 617

Query: 294 TRTSSEPEVSVLPKRPRPAEFKALSKKPPQPELGGLPRTSSEPEFNSLPRKL-------L 346
             T+S+P   + P  P P         PP P    LP  S+    ++ P  +       L
Sbjct: 618 PYTASQPSPPLPPPPPPPPP----PPPPPPPPPPPLPSQSAPSAGSAAPMFVKYSTITRL 673

Query: 347 QPERRGPPRKFSQPEPSAVLKRHPQPEFF---------GDLPRKPPLPSSASESSLPAAV 397
           Q   +     F  P P  +  +  +P+              P  PP P SA     PA  
Sbjct: 674 QNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPGSAMAQLKPAPC 733

Query: 398 AGFSSRHPLSPGFGAAGTPRWRSGGLVHSGGARPGLRPSHPPRRRPLPPASSLGHPPAKP 457
           A      P  P F +A  P  +   + H     P   P  PP   PLPP +     P KP
Sbjct: 734 A------PSLPQF-SAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQA-----PPKP 781

Query: 458 ----PLPP-----GPVDMQSFRRPSAASIDLRRTRSAAGLHFQDRQPEDIPVPDEIYELY 508
               P P       PV  Q+        +   + + A    +    P   PVP     + 
Sbjct: 782 LVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPSPPTPPVP-----VP 836

Query: 509 DDVEPRDDS---SPSPKGRDEAPS-VQQAARR---PPQDPALRKEK-DPQPQQLPPMDPK 560
               P+  S    P P      PS V+Q A +   PP  PA+  +   P P  + P  P 
Sbjct: 837 PPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPAMESQPLKPVPANVAPQSPP 896

Query: 561 LLK 563
            +K
Sbjct: 897 AVK 899



 Score = 31.6 bits (70), Expect = 2.5
 Identities = 28/121 (23%), Positives = 46/121 (38%), Gaps = 13/121 (10%)

Query: 5    LPAAMESHQDFRSIKAKFQASQPEPSDLPKKPP--KPEFGKLKKFSQPELSEHPKKAPL- 61
            +PA    +   +      Q  Q     + K PP  +P+     + +Q E+SE P  A + 
Sbjct: 1089 IPAVFSGNTSPKVAVVNPQPQQWSKMSVKKAPPPTRPKRNDSTRLTQAEISEQPTMATVV 1148

Query: 62   ---PEFGAVSLKPPPPEVTDLPKKPPPPEVTD-------LPKKPPPPEVTDLPKKPPPPE 111
               P     SL   P  + DL +      +T        + +  P   + D+   PPPPE
Sbjct: 1149 PQVPTSPKSSLSVQPGFLADLNRTLQRKSITRHGSLSSRMSRAEPTATMDDMALPPPPPE 1208

Query: 112  V 112
            +
Sbjct: 1209 L 1209


>gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens]
          Length = 416

 Score = 93.2 bits (230), Expect = 7e-19
 Identities = 119/454 (26%), Positives = 163/454 (35%), Gaps = 84/454 (18%)

Query: 48  SQPELSEHPKKAPLPEFGAVSLKPPPPEVTDLPKKPPPPEVTDLPKKP--PPPEVTDLPK 105
           S   L+E   +   P   A + +  PP+  + P+ PP P     P KP  PPP+  + P+
Sbjct: 15  SAQNLNEDVSQEESPSLIAGNPQGAPPQGGNKPQGPPSP-----PGKPQGPPPQGGNQPQ 69

Query: 106 KPPPPEVTDLPKKPSKLELSDLSKKFPQLGATPFPRKPLQPEVGEAPLKASLPEPGAPAR 165
            PPPP     P KP            PQ G      KP  P           P PG P  
Sbjct: 70  GPPPP-----PGKPQGPP--------PQGG-----NKPQGP-----------PPPGKPQG 100

Query: 166 KPLQPDELSHPARPPSEPKSGAFPRKLWQPEAGEATPRSPQPELSTFPKKP--AQPEFNV 223
            P Q D+   P  PP +P+          P  G   P+ P P     P KP    P+   
Sbjct: 101 PPPQGDKSRSPRSPPGKPQG--------PPPQGGNQPQGPPPP----PGKPQGPPPQGGN 148

Query: 224 YPKKPPQPQVGGLPKKSVPQPE-FSEAAQTPLWKPQSSEPK-------------RDSSAF 269
            P+ PP P   G P+   PQ +  S ++++P  KPQ   P+             +     
Sbjct: 149 KPQGPPPP---GKPQGPPPQGDNKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPP 205

Query: 270 PKKASQPPLSDFPKKPPQPELGDLTRTSSEPEVSVLPKRPRPAEFKALSKKPPQP--ELG 327
           P+  ++P     P KP  P      ++ S       P+ P P         PP P    G
Sbjct: 206 PQGGNKPQGPPPPGKPQGPPPQGDNKSQSARSPPGKPQGPPPQGGNQPQGPPPPPGKPQG 265

Query: 328 GLPRTSSEPEFNSLPRKLLQPERRGPPRKFSQPEPSAVLKRHPQPEFFGDLPRKPPLPSS 387
             P+  ++P+    P K   P  +G  +  S   P    K    P   G+ P+ PP P  
Sbjct: 266 PPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSSRSPPG--KPQGPPPQGGNQPQGPPPPPG 323

Query: 388 ASESSLPAAVAGFSSRHPLSPGFGAAGTPRWRSGGLVHSGGARPGLRPSHPPRRR----- 442
             +   P    G   + P  PG      P+   GG        P  +P  PP++      
Sbjct: 324 KPQG--PPPQGGNKPQGPPPPGKPQGPPPQ---GGSKSRSARSPPGKPQGPPQQEGNNPQ 378

Query: 443 -PLPPASSLGHPPAKPPL--PPGPVDMQSFRRPS 473
            P PPA      P  PP   P GP       RPS
Sbjct: 379 GPPPPAGGNPQQPQAPPAGQPQGPPRPPQGGRPS 412



 Score = 92.8 bits (229), Expect = 9e-19
 Identities = 120/434 (27%), Positives = 165/434 (38%), Gaps = 94/434 (21%)

Query: 52  LSEHPKKAPLPEFGAVSLKPPPPEVTDLPKKP--PPPEVTDLPKKP---------PPPEV 100
           ++ +P+ AP P+ G     PP P     P KP  PPP+  + P+ P         PPP+ 
Sbjct: 32  IAGNPQGAP-PQGGNKPQGPPSP-----PGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQG 85

Query: 101 TDLPKKPPPPEVTDLPKKPSKLELSDLSK------------KFPQLGATPFPRKPLQPEV 148
            + P+ PPPP     P        S  S               PQ G  P P KP  P  
Sbjct: 86  GNKPQGPPPPGKPQGPPPQGDKSRSPRSPPGKPQGPPPQGGNQPQ-GPPPPPGKPQGPPP 144

Query: 149 GEAPLKASLPEPGAPARKPLQPDELSHPAR-PPSEPKSGAFPRKLWQPEAGEATPRSPQP 207
                    P PG P   P Q D  S  +R PP +P+          P  G   P+ P P
Sbjct: 145 QGGNKPQGPPPPGKPQGPPPQGDNKSRSSRSPPGKPQG--------PPPQGGNQPQGPPP 196

Query: 208 ELSTFPKKP--AQPEFNVYPKKPPQPQVGGLPKKSVPQPE-FSEAAQTPLWKPQSSEPK- 263
                P KP    P+    P+ PP P   G P+   PQ +  S++A++P  KPQ   P+ 
Sbjct: 197 P----PGKPQGPPPQGGNKPQGPPPP---GKPQGPPPQGDNKSQSARSPPGKPQGPPPQG 249

Query: 264 ------------RDSSAFPKKASQPPLSDFPKKP--PQPELGDLTRTSSEPEVSVLPKRP 309
                       +     P+  ++P     P KP  P P+ G  +R+S  P     P+ P
Sbjct: 250 GNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSSRSPPGK--PQGP 307

Query: 310 RPAEFKALSKKPPQP--ELGGLPRTSSEPEFNSLPRKLLQPERRGPPRKFSQPEPSAVLK 367
            P         PP P    G  P+  ++P+    P K   P  +G  +  S   P    +
Sbjct: 308 PPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSARSPPGKPQ 367

Query: 368 RHPQPEFFGDLPRKPPLPSSASESSLPAAVAGFSSRHPLSPGFG-AAGTPRWRSGGLVHS 426
             PQ E  G+ P+ PP P            AG + + P +P  G   G PR   GG    
Sbjct: 368 GPPQQE--GNNPQGPPPP------------AGGNPQQPQAPPAGQPQGPPRPPQGG---- 409

Query: 427 GGARPGLRPSHPPR 440
                  RPS PP+
Sbjct: 410 -------RPSRPPQ 416



 Score = 91.3 bits (225), Expect = 3e-18
 Identities = 104/369 (28%), Positives = 139/369 (37%), Gaps = 59/369 (15%)

Query: 21  KFQASQPEPSDLPKKPPKPEFGKLK-KFSQPELSEHPKKAPLPEFGAVSLKPPPPEVTDL 79
           K Q   P+  + P+ PP P  GK +    Q + S  P+  P    G      PPP+  + 
Sbjct: 77  KPQGPPPQGGNKPQGPPPP--GKPQGPPPQGDKSRSPRSPPGKPQG------PPPQGGNQ 128

Query: 80  PKKPPPPEVTDLPKKP--PPPEVTDLPKKPPPPEVTDLPKKPSKLELSDLSKKFPQ---- 133
           P+ PPPP     P KP  PPP+  + P+ PPPP     P  P + +    S + P     
Sbjct: 129 PQGPPPP-----PGKPQGPPPQGGNKPQGPPPPGKPQGP--PPQGDNKSRSSRSPPGKPQ 181

Query: 134 ----------LGATPFPRKPLQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARPPSEP 183
                      G  P P KP  P           P PG P   P Q D  S  AR P   
Sbjct: 182 GPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSQSARSPPGK 241

Query: 184 KSGAFPRKLWQPEAGEATPRSPQPELSTFPKKPAQPEFNVYPKKPPQPQVGGLPKKS--- 240
             G  P+   QP+     P  PQ        KP  P     P+ PP PQ G   + S   
Sbjct: 242 PQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPP-PQGGSKSRSSRSP 300

Query: 241 -----VPQPEFSEAAQTPLWKPQSSEPKRDSSAFPKKASQPPLSDFPKKPPQPELGDLTR 295
                 P P+     Q P   P   +P+        K   PP    P+ PP P+ G  +R
Sbjct: 301 PGKPQGPPPQGGNQPQGP--PPPPGKPQGPPPQGGNKPQGPPPPGKPQGPP-PQGGSKSR 357

Query: 296 TSSEPEVSVLPKRPR-PAEFKALSKKPPQPELGGLPRTSSEPEFNSLPRKLLQPERRGPP 354
           ++  P     P +P+ P + +  + + P P  GG P+    P          QP+  GPP
Sbjct: 358 SARSP-----PGKPQGPPQQEGNNPQGPPPPAGGNPQQPQAPPAG-------QPQ--GPP 403

Query: 355 RKFSQPEPS 363
           R      PS
Sbjct: 404 RPPQGGRPS 412



 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 95/384 (24%), Positives = 126/384 (32%), Gaps = 65/384 (16%)

Query: 195 PEAGEATPRSPQPELSTFPKKPA--QPEFNVYPKKPPQPQVGGLPKKSVPQPEFSEAAQT 252
           P+ G      P P     P KP    P+    P+ PP P   G P+   PQ         
Sbjct: 41  PQGGNKPQGPPSP-----PGKPQGPPPQGGNQPQGPPPPP--GKPQGPPPQGGNKPQGPP 93

Query: 253 PLWKPQSSEPKRDSSAFPKKASQPPLSDFPKKPPQPELGDLTRTSSEPEVSVLPKRPRPA 312
           P  KPQ   P+ D S  P+          P KP  P           P+    P+ P P 
Sbjct: 94  PPGKPQGPPPQGDKSRSPRSP--------PGKPQGP----------PPQGGNQPQGPPP- 134

Query: 313 EFKALSKKPPQPELGGLPRTSSEPEFNSLPRKLLQPERRGPPRKFSQPEPSAVLKRHPQP 372
                   PP    G  P+  ++P+    P K   P  +G  +  S   P    K    P
Sbjct: 135 --------PPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSRSSRSPPG--KPQGPP 184

Query: 373 EFFGDLPRKPPLPSSASESSLPAAVAGFSSRHPLSPGFGAAGTPRWRSGGLVHSGGARPG 432
              G+ P+ PP P    +   P    G   + P  PG      P+   G         P 
Sbjct: 185 PQGGNQPQGPPPPPGKPQG--PPPQGGNKPQGPPPPGKPQGPPPQ---GDNKSQSARSPP 239

Query: 433 LRPSHP-------PRRRPLPPASSLGHPPA---KPPLPPGPVDMQSFRRPSAASIDLRRT 482
            +P  P       P+  P PP    G PP    KP  PP P   Q    P       R +
Sbjct: 240 GKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQG--PPPQGGSKSRSS 297

Query: 483 RSAAGL-----HFQDRQPEDIPVPDEIYELYDDVEPRDDSSPSPKGRDEAP-----SVQQ 532
           RS  G           QP+  P P    +            P P G+ + P     S  +
Sbjct: 298 RSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSR 357

Query: 533 AARRPPQDPALRKEKDPQPQQLPP 556
           +AR PP  P    +++    Q PP
Sbjct: 358 SARSPPGKPQGPPQQEGNNPQGPP 381



 Score = 36.6 bits (83), Expect = 0.077
 Identities = 54/215 (25%), Positives = 72/215 (33%), Gaps = 37/215 (17%)

Query: 358 SQPEPSAVLKRHPQ--PEFFGDLPRKPPLPSSASESSLPAAVAGFSSRHPLSPGFGAAGT 415
           SQ E  +++  +PQ  P   G+ P+ PP P    +   P    G   + P  P     G 
Sbjct: 24  SQEESPSLIAGNPQGAPPQGGNKPQGPPSPPGKPQG--PPPQGGNQPQGPPPPPGKPQGP 81

Query: 416 PRWRSGGLVHSGGARPGLRPSHPPR----RRPL-PPASSLGHPPA---KPPLPPGPVDMQ 467
           P    GG    G   PG     PP+    R P  PP    G PP    +P  PP P    
Sbjct: 82  PP--QGGNKPQGPPPPGKPQGPPPQGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKP 139

Query: 468 SFRRPSAASIDLRRTRSAAGLHFQDRQPEDIPVPDEIY--ELYDDVEPRDDSSPSPKGRD 525
               P   +                 +P+  P P +        D + R   SP  K + 
Sbjct: 140 QGPPPQGGN-----------------KPQGPPPPGKPQGPPPQGDNKSRSSRSPPGKPQG 182

Query: 526 EAPSVQQAARRPPQDPALRKEKDPQ----PQQLPP 556
             P      + PP  P   +   PQ    PQ  PP
Sbjct: 183 PPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPP 217


>gi|150170670 piccolo isoform 2 [Homo sapiens]
          Length = 4935

 Score = 90.1 bits (222), Expect = 6e-18
 Identities = 141/567 (24%), Positives = 208/567 (36%), Gaps = 99/567 (17%)

Query: 21  KFQASQPEPSDLPKKPPKPEFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPPPEVTDLP 80
           K  A QP P+    KPP  + G  K  +Q    + P KAP P    V  +P P ++   P
Sbjct: 399 KTPAQQPGPA----KPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQ-QPGPGKI---P 450

Query: 81  KKPPPPEVTDLPKKPP--PPEVTDLPKKPPPPEVTDLPKKPSKLELSDLSKKFPQLGATP 138
            +   P  T   +  P  PP     P KPPP +    P KP   +         Q G+T 
Sbjct: 451 AQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPG--PAKPPPQQPGSAKPPSQQPGSTK 508

Query: 139 FPRKPLQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARPPSEPKSGAFPRKLWQPEAG 198
            P  P QP     P K S  +PG+               +PPS+    A P       A 
Sbjct: 509 PP--PQQP----GPAKPSPQQPGS--------------TKPPSQQPGSAKPSAQQPSPAK 548

Query: 199 EATPRSPQPELSTFPKKPAQPEFNVYPKKPPQPQVGGLPKKSVPQPEFSEAAQTPLWKPQ 258
            +  +S +P   T   KP QP   V P    QP   GLPK   P        +  L  P+
Sbjct: 549 PSAQQSTKPVSQTGSGKPLQPP-TVSP-SAKQPPSQGLPKTICP---LCNTTELLLHVPE 603

Query: 259 SSEPKRDSSAFPKKASQPPLSDFPKKPPQPEL---------------GDLTRTSSEPEVS 303
            +     +       S   L  F   P   E+               GDL    S P+  
Sbjct: 604 KANFNTCTECQTTVCS---LCGFNPNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPK 660

Query: 304 VLPKRPRPAEFKALSKKPPQPELGGLPRTSSEPEFNSLPRKLLQ--PERRGPPRKFSQP- 360
           +  K        A+SK  PQP+        + P+ ++ P++ L   PE + PP    QP 
Sbjct: 661 L--KTAPVTTTSAVSKSSPQPQ-------QTSPKKDAAPKQDLSKAPEPKKPPPLVKQPT 711

Query: 361 ---EPSAVLKRHPQPEFFGDLPRKPPLPSSASESSLPAAVAGFSSRHP--LSPGFGAAGT 415
               PSA  K+ P+ +     P  P  PS  SE    A VA    + P  + P       
Sbjct: 712 LHGSPSAKAKQPPEADSLSK-PAPPKEPSVPSEQD-KAPVADDKPKQPKMVKP------- 762

Query: 416 PRWRSGGLVHSGGAR-----PGLRPSHPPRRRPLPPASSLGHPPAKPPLPPG----PVDM 466
               +  LV S  A      P  +       +  PP  +    P++   P G    P D 
Sbjct: 763 ----TTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDS 818

Query: 467 QSFRRPSAASIDLRRTRSAAGLHFQDRQPEDIPVPDEIYELYDDVEPRDDSSPSPKGRDE 526
           ++  RP++ S  +     ++    Q +Q + +   +E  +    + P+ D+ P PKG   
Sbjct: 819 KAIPRPASDSKIISHPGPSSESKGQ-KQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPT 877

Query: 527 APSVQQAARRPPQDPALRKEKDPQPQQ 553
            P  +  A +    P    ++ P+PQ+
Sbjct: 878 PPGPRPTAGQTVPTP----QQSPKPQE 900



 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 139/574 (24%), Positives = 209/574 (36%), Gaps = 96/574 (16%)

Query: 25  SQP----EPSDLPKKPPKPEFGKL---KKFSQPELSEHPKKAPLPEFGAVSLKPPPPEVT 77
           SQP    +P   P + P+ +  KL   +  S+P+     K+A +      S+KP  P   
Sbjct: 249 SQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQT----KQADIVR--GESVKPSLPS-- 300

Query: 78  DLPKKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPSKLELSDLSKKFPQLGAT 137
             P KPP  + T  P KPP  +      +P P +    P +PS      L+K   Q   T
Sbjct: 301 --PSKPPIQQPT--PGKPPAQQPGHEKSQPGPAKP---PAQPS-----GLTKPLAQQPGT 348

Query: 138 PFPRKPLQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARPPSEPKSGAFPRKLWQPEA 197
             P  P+QP     P      +P  PA+ P Q      P+     PK+ A P  + +  A
Sbjct: 349 VKP--PVQPPGTTKPPA----QPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPA 402

Query: 198 GEATPRSPQPELSTFPKKPAQPEFNVYPKKPPQPQVGGLPKKSVPQPE----FSEAAQTP 253
            +  P  P  +    PK  AQ      P K P P      K  V QP      ++ A   
Sbjct: 403 QQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGP-----TKTPVQQPGPGKIPAQQAGPG 457

Query: 254 LWKPQSSEPKRDSSAFPKKASQPPLSDFPKKPPQPELGDLTRTSSEP-EVSVLPKRPRPA 312
               Q + P +  S  P  A  PP    P KPP  + G     S +P      P++P PA
Sbjct: 458 KTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPA 517

Query: 313 E---FKALSKKPPQPELGGL-------------PRTSSEPEFNSLPRKLLQPERRGPPRK 356
           +    +  S KPP  + G                + S++P   +   K LQP    P  K
Sbjct: 518 KPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAK 577

Query: 357 F--SQPEPSAVLKRHPQPEFFGDLPRKPPLPSSASESSLPAAVAGFSSRHPLSPGFGAAG 414
              SQ  P  +       E    +P K    +     +   ++ GF+    L+       
Sbjct: 578 QPPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFNPNPHLTE------ 631

Query: 415 TPRW--RSGGLVHSGGARPGLRPSHPPRRRPLPPASSLGHPPAKPPLPPGPVDMQSFRRP 472
              W   +  +  + G      PS P  +    P ++        P P       S ++ 
Sbjct: 632 VKEWLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQP----QQTSPKKD 687

Query: 473 SAASIDLRRTRSAAGLHFQDRQPEDIPVPDEIYELYDDVEPRDDSSPSPKGRD--EAPSV 530
           +A   DL             + PE    P  +       +P    SPS K +   EA S+
Sbjct: 688 AAPKQDL------------SKAPEPKKPPPLV------KQPTLHGSPSAKAKQPPEADSL 729

Query: 531 QQAARRPPQDPALRKEKDPQP-QQLPPMDPKLLK 563
            + A  PP++P++  E+D  P     P  PK++K
Sbjct: 730 SKPA--PPKEPSVPSEQDKAPVADDKPKQPKMVK 761



 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 81/345 (23%), Positives = 127/345 (36%), Gaps = 36/345 (10%)

Query: 30  SDLPKKPPKPEFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPPPEVTDLPKKPPPPEVT 89
           S + K  P+P+    KK + P+  +   KAP P+     +K P    +   K   PPE  
Sbjct: 670 SAVSKSSPQPQQTSPKKDAAPK--QDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEAD 727

Query: 90  DLPKKPPPPEVTDLPKKPPPPEVTDLPKKPSKLE-LSDLSKKFPQLGATPFPRKPLQPEV 148
            L K  PP E +   ++   P   D PK+P  ++  +DL            P   +Q + 
Sbjct: 728 SLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQA 787

Query: 149 GE---APLKASLPEPG---APARKPLQPDELSHPARPPSEPKSGAFPRKLWQPEAGEATP 202
            E    PLK    +P     P  + + P +     RP S+ K  + P        G ++ 
Sbjct: 788 EEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHP--------GPSSE 839

Query: 203 RSPQPELSTFPKK--PAQPEFNVYPKKPPQPQVGGLPKKSVPQPEFSEAAQTPLWKPQSS 260
              Q ++    KK  P + +  + PK   +P   G P    P+P   +   TP    QS 
Sbjct: 840 SKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPTP---QQSP 896

Query: 261 EPKRDSSAFPKKASQPPLSDFPKKPPQPELGDLTRTSSEPEVSVLPKRPRPAEFKALSKK 320
           +P+  S  F        ++D PK  P      +T        S+       ++   L   
Sbjct: 897 KPQEQSRRFSLNLGS--ITDAPKSQPTTPQETVTGKLFGFGASIF------SQASNLIST 948

Query: 321 PPQPELGGLPRTSSEP--EFNSLPRKLLQPERRGPPRKFSQPEPS 363
             QP     P + S P       P     P  +GPP+   Q  P+
Sbjct: 949 AGQPG----PHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPA 989



 Score = 67.0 bits (162), Expect = 5e-11
 Identities = 116/516 (22%), Positives = 174/516 (33%), Gaps = 131/516 (25%)

Query: 69   LKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPSKLELSDLS 128
            L P P       K  P    + + K  P P+ T  PKK   P+              DLS
Sbjct: 650  LAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTS-PKKDAAPK-------------QDLS 695

Query: 129  KKFPQLGATPFPRKPLQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARPPSEPKSGAF 188
            K        P P+KP  P V +  L  S   P A A++P + D LS PA PP EP     
Sbjct: 696  K-------APEPKKP-PPLVKQPTLHGS---PSAKAKQPPEADSLSKPA-PPKEP----- 738

Query: 189  PRKLWQPEAGEATPRSPQPELSTFPKKPAQPEFNVYPKKPPQPQVGGLPKKSVPQPEFSE 248
                        +  S Q +      KP QP+  V P            K  +P  +   
Sbjct: 739  ------------SVPSEQDKAPVADDKPKQPKM-VKPTTDLVSSSSATTKPDIPSSKVQS 785

Query: 249  AAQ---TPLWKPQSSEPKR------------DSSAFPKKASQPPLSDFPKKPPQPELGDL 293
             A+   TP  K  S++P +            DS A P+ AS   +   P        G  
Sbjct: 786  QAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHP--------GPS 837

Query: 294  TRTSSEPEVSVLPKRPRPAEFKALSKKPPQPELGGLPRTSSEPEFNSLPRKLLQPERRGP 353
            + +  + +V  + K+  P   KA +K  P+P+   +P+ S  P               GP
Sbjct: 838  SESKGQKQVDPVQKKEEPK--KAQTKMSPKPDAKPMPKGSPTPP--------------GP 881

Query: 354  PRKFSQPEPSAVLKRHPQPEF------FGDLPRKPPLPSSASESSLPAAVAGFSSR--HP 405
                 Q  P+      PQ +        G +   P    +  + ++   + GF +     
Sbjct: 882  RPTAGQTVPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQ 941

Query: 406  LSPGFGAAGTPRWRSGGLVHSGGARPGLRPSHPPRRRPLP--PASSLGHPPAKPPLPPGP 463
             S     AG P           G      P  P ++ P P  P +S G P +    PP P
Sbjct: 942  ASNLISTAGQP-----------GPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAP 990

Query: 464  VDMQSFRRPSAASIDLRRTRSAAGLHFQDRQPEDIPVPDEIYELYDDVEPRDDSSPSPKG 523
                      A SI +++   A      + + E  P           V+  +     P  
Sbjct: 991  ----------AKSIPVKKETKAPAAEKLEPKAEQAPT----------VKRTETEKKPPPI 1030

Query: 524  RDEAPSVQQAARRPPQDPAL--RKEKDPQPQQLPPM 557
            +D      ++    PQ   L  + EK P+P+   P+
Sbjct: 1031 KD-----SKSLTAEPQKAVLPTKLEKSPKPESTCPL 1061



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 79/297 (26%), Positives = 109/297 (36%), Gaps = 70/297 (23%)

Query: 41   FGKLKKFSQ-----PELSEHPKKAPLPEFGAVSLKPPPPEVTDLPKKPPPPEVTDLPKKP 95
            FG+ K  SQ     P +S  P K P P F + SL        D+  +PPPP        P
Sbjct: 2367 FGQEKPASQLPSGSPSVSSLPAK-PRPFFRSSSL--------DISAQPPPPP------PP 2411

Query: 96   PPPEVTDLPKKPPPPEVTDLPKKPSKLELSDLSKKFPQLGATPFPRKPLQPEVGEAPLKA 155
            PPP     P  PPPP       KP+ L    L+   P   AT     PL   V      A
Sbjct: 2412 PPPPPPPPPPPPPPPLPPPTSPKPTILPKKKLTVASPVTTAT-----PLFDAVTTLETTA 2466

Query: 156  SLPEPGAPARKPLQPDELSHPARPPSEPKSGAFPRKLW-----QPEAGEATPRSPQPELS 210
             L   G P  +      +   A PP  PK  + P  L      +P      P+   P+L 
Sbjct: 2467 VLRSNGLPVTR------ICTTAPPPVPPKPSSIPSGLVFTHRPEPSKPPIAPKPVIPQLP 2520

Query: 211  TFPKKPAQPEFNVYPK--------------------KPPQPQVGGLPKKSVPQPEFSEA- 249
            T  +KP     +++PK                    K P P     P  +   P FS++ 
Sbjct: 2521 TTTQKPT----DIHPKPTGLSLTSSMTLNLVTSADYKLPSPTSPLSPHSNKSSPRFSKSL 2576

Query: 250  AQTPLWKPQSSEPKRDSSAFPKKASQPPLSDFPKKPPQPELGDLTRTSSEPEVSVLP 306
             +T +     SEP   + +   +A    ++ +P   P  +L      S EP  SV+P
Sbjct: 2577 TETYVVITLPSEPGTPTDSSASQA----ITSWPLGSPSKDL-----VSVEPVFSVVP 2624



 Score = 56.2 bits (134), Expect = 9e-08
 Identities = 132/570 (23%), Positives = 201/570 (35%), Gaps = 84/570 (14%)

Query: 6   PAAMESHQDFRSIKAKFQASQP-EPSDLPKKPPKPEFGKLKKFSQPELSEHPKKAPLPEF 64
           PAA ES    R  K +  +S P + S  P  P +P    L K    +     +K P    
Sbjct: 73  PAAAESPSMHR--KQELDSSHPPKQSGRPPDPGRPAQPGLSKSRTTDTFRSEQKLPGRSP 130

Query: 65  GAVSLKPPPPEVTDLPKKPPPPEVTD-LPKKPPPPEVTDLPKKPPPPEVTDLPKKPSKLE 123
             +SLK      TDL ++     +   L +      V+ +  K  P ++     + S+ E
Sbjct: 131 STISLKESKSR-TDLKEEHKSSMMPGFLSEVNALSAVSSVVNKFNPFDLIS-DSEASQEE 188

Query: 124 LSDLSKKFPQLGATPFPRKPLQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARPPSEP 183
            +   K   +    P     ++P + + P K  +P+   P R PLQ D       P S  
Sbjct: 189 TTKKQKVVQKEQGKP--EGIIKPPLQQQPPKP-IPKQQGPGRDPLQQD-----GTPKSIS 240

Query: 184 KSGAFPRKLWQPEAGEATPRSPQPELSTFPKKPAQPEFNVYPKKPPQPQVGGLPKKSVPQ 243
                  K   P  G+      Q   +   K P Q + +    K      G   K S+P 
Sbjct: 241 SQQPEKIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPS 300

Query: 244 PEFSEAAQTPLWKPQSSEPKRDSSAFPKKASQPPLSDFPKKPPQPELGDLTRTSSEPEVS 303
           P      Q    KP + +P  +        SQP     P KPP    G LT+  ++   +
Sbjct: 301 PSKPPIQQPTPGKPPAQQPGHEK-------SQPG----PAKPPAQPSG-LTKPLAQQPGT 348

Query: 304 VLPKRPRPAEFKALSK-----KPPQPELGGLPRTSSEPEFNSLPRKLLQPERRG--PPRK 356
           V P    P   K  ++     KPP  + G    +S +P     P+ L QP   G  P ++
Sbjct: 349 VKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPG----PKALAQPPGVGKTPAQQ 404

Query: 357 FSQPEPSAVLKRHPQPEFFGDLPRKPPLPSSASESSLPAAVAGFSSRHPLSPGFGAAGTP 416
               +P       P+P     L ++P L S       PA   G +      PG       
Sbjct: 405 PGPAKPPTQQVGTPKP-----LAQQPGLQS-------PAKAPGPTKTPVQQPG------- 445

Query: 417 RWRSGGLVHSGGARPGLRPSHPPRRRPLPPASSLGHPPAKPPLPPGPVDMQSFRRPSAAS 476
                G + +  A PG   +   +  P  P S L  P   PP  PGP      ++P +A 
Sbjct: 446 ----PGKIPAQQAGPG--KTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPP-QQPGSAK 498

Query: 477 IDLRRTRSAAGLHFQDRQPEDIPVPDEIYELYDDVEPRDDSSPSPKGRDEAPSVQQAARR 536
              ++  S        + P   P P +        +P     PS +     PS QQ +  
Sbjct: 499 PPSQQPGST-------KPPPQQPGPAK----PSPQQPGSTKPPSQQPGSAKPSAQQPS-- 545

Query: 537 PPQDPALRKEKDP-------QPQQLPPMDP 559
            P  P+ ++   P       +P Q P + P
Sbjct: 546 -PAKPSAQQSTKPVSQTGSGKPLQPPTVSP 574



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 92/400 (23%), Positives = 137/400 (34%), Gaps = 95/400 (23%)

Query: 235 GLPKKSVPQPEFSEAAQTPLWKPQSSEPKRDSSAFPKKASQPPLSDFPKKPPQPELGDLT 294
           GLPK SVP      AA++P       + + DSS  PK++ +PP    P +P QP L    
Sbjct: 65  GLPKGSVP----PAAAESP---SMHRKQELDSSHPPKQSGRPP---DPGRPAQPGLSKSR 114

Query: 295 RTSS----------EPEVSVLPKRPRPAEFKALSKKPPQP----ELGGLPRTSS------ 334
            T +           P    L +     + K   K    P    E+  L   SS      
Sbjct: 115 TTDTFRSEQKLPGRSPSTISLKESKSRTDLKEEHKSSMMPGFLSEVNALSAVSSVVNKFN 174

Query: 335 ----------EPEFNSLPRKLLQPERRGPPRKFSQPEPSAVLKRHPQPEFFGDLPRKPPL 384
                       E  +  +K++Q E +G P    +P    + ++ P+P      P + PL
Sbjct: 175 PFDLISDSEASQEETTKKQKVVQKE-QGKPEGIIKP---PLQQQPPKPIPKQQGPGRDPL 230

Query: 385 PSSASESSLPAAVAGFSSRHPLSPGFGA---------------------AGTPRWRSGGL 423
               +  S+ +         P  PG G                      A  P+ +   +
Sbjct: 231 QQDGTPKSISSQQPEKIKSQP--PGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADI 288

Query: 424 VHSGGARPGL-RPSHPPRRRPL---PPASSLGHP-----PAKPPLPPGPVDMQSFRRPSA 474
           V     +P L  PS PP ++P    PPA   GH      PAKPP  P  +     ++P  
Sbjct: 289 VRGESVKPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGT 348

Query: 475 ASIDLR---RTRSAAGLHFQDRQPEDIPVPDEIYELYDDVEPRDDSSPSPKGRDEAPSVQ 531
               ++    T+  A    Q   P   P      E     +P   +   P G  + P+ Q
Sbjct: 349 VKPPVQPPGTTKPPA----QPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQ 404

Query: 532 QAARRPP-----------QDPALRK-EKDPQPQQLPPMDP 559
               +PP           Q P L+   K P P + P   P
Sbjct: 405 PGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQP 444



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 85/407 (20%), Positives = 145/407 (35%), Gaps = 61/407 (14%)

Query: 31   DLPKKPPKPEFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPPPEVTDLPKKPPPPEVTD 90
            D  +K  +P+  + K   +P+    PK +P P       +P   +    P++ P P+   
Sbjct: 847  DPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPP----GPRPTAGQTVPTPQQSPKPQEQS 902

Query: 91   LPKKPPPPEVTDLPK-KPPPPEVTDLPK----------KPSKLELSDLSKKFPQLGATP- 138
                     +TD PK +P  P+ T   K          + S L +S   +  P   + P 
Sbjct: 903  RRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNL-ISTAGQPGPHSQSGPG 961

Query: 139  FPRK----PLQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARPPSEPKSGAFPRKLWQ 194
             P K    P QP   + P K++   P APA+      E   PA    EPK+   P     
Sbjct: 962  APMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEKLEPKAEQAPTVKRT 1021

Query: 195  PEAGEATPRSPQPELSTFPKKPAQP------------------EFNVYPKKPPQPQVGGL 236
                +  P      L+  P+K   P                  E N+  K PP       
Sbjct: 1022 ETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPKPESTCPLCKTELNIGSKDPPNFNTCTE 1081

Query: 237  PKKSV-------PQPEFSEAAQTPLWKPQSSEPKRD-SSAFPKKASQPPLSDFPKKPPQP 288
             K  V       P P  +E  +   W   + + +R  S         PP    PK  P P
Sbjct: 1082 CKNQVCNLCGFNPTPHLTEIQE---WLCLNCQTQRAISGQLGDIRKMPPAPSGPKASPMP 1138

Query: 289  ELGDLT--RTSSEPEVSVLPKRPRPAEFKALSKKPPQPELGGLPRTSSEPEFNSLPRKLL 346
               + +  +T+  P+V ++ K+ +  + +A        E   L +         +P  ++
Sbjct: 1139 VPTESSSQKTAVPPQVKLVKKQEQEVKTEA--------EKVILEKVKETLSMEKIP-PMV 1189

Query: 347  QPERRGPPRKFSQPEPSAVLKRHPQPEFFGDLPRKPPLPSSASESSL 393
              +++    K  + + SA+ ++ P PE    +P +  + S   +  L
Sbjct: 1190 TTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEEKIRSEEKKPLL 1236



 Score = 37.0 bits (84), Expect = 0.059
 Identities = 60/235 (25%), Positives = 81/235 (34%), Gaps = 57/235 (24%)

Query: 108  PPPEVTDLPKKPSKLELSDLSKKFPQLGATPFPRKPLQPEVGEAPLKASLPEPGAPARKP 167
            PP  V  LP K        LS  +   G T    KP       +P  +SLP    P  + 
Sbjct: 2343 PPSSVIALPMK------EQLSTTYFTSGETFGQEKPASQLPSGSPSVSSLPAKPRPFFRS 2396

Query: 168  LQPDELSHPARPPSEPKSGAFPRKLWQPEAGEATPRSPQPELSTFPKKPAQPEFNVYPKK 227
               D  + P  PP  P           P      P  P P L      P  P+  + PKK
Sbjct: 2397 SSLDISAQPPPPPPPP-----------PPPPPPPPPPPPPPL----PPPTSPKPTILPKK 2441

Query: 228  PPQPQVGGLPKKSVPQPEFSEAAQTPLWKPQSSEPKRDSSAFPKKASQPP----LSDFPK 283
                      K +V  P       TPL+   ++    +++A  +    P      +  P 
Sbjct: 2442 ----------KLTVASP---VTTATPLFDAVTT---LETTAVLRSNGLPVTRICTTAPPP 2485

Query: 284  KPPQPELGDLTRTSSEPEVSVLPKRPRPAEFKALSKKP--PQPELGGLPRTSSEP 336
             PP+P        SS P   V   RP P      SK P  P+P +  LP T+ +P
Sbjct: 2486 VPPKP--------SSIPSGLVFTHRPEP------SKPPIAPKPVIPQLPTTTQKP 2526



 Score = 32.0 bits (71), Expect = 1.9
 Identities = 28/100 (28%), Positives = 43/100 (43%), Gaps = 8/100 (8%)

Query: 478  DLRRTRSAAGLHFQDRQPEDIPVPDEIYELYDDVEPRDDSSPSPKGRDEAPSVQQAARRP 537
            D  R   ++ LH     P   P    +  L +D     DSSPS K  +     Q+ AR  
Sbjct: 1710 DRSRGEGSSSLHASSFTPGTSPT--SVSSLDED----SDSSPSHKKGESKQ--QRKARHR 1761

Query: 538  PQDPALRKEKDPQPQQLPPMDPKLLKQLRKAEKAEREFRK 577
            P  P L   +D   ++    + +LLK+  K  + E++ RK
Sbjct: 1762 PHGPLLPTIEDSSEEEELREEEELLKEQEKQREIEQQQRK 1801



 Score = 31.6 bits (70), Expect = 2.5
 Identities = 33/90 (36%), Positives = 35/90 (38%), Gaps = 26/90 (28%)

Query: 373  EFFGDLPRKPPLPS-SASESSLPAAVAGFSSRHPLSPGFGAAGTPRWRSGGLVHSGGARP 431
            E FG       LPS S S SSLPA    F                 +RS  L  S  A+P
Sbjct: 2365 ETFGQEKPASQLPSGSPSVSSLPAKPRPF-----------------FRSSSLDIS--AQP 2405

Query: 432  GLRPSHPPRRRPLPPASSLGHPPAKPPLPP 461
               P  PP   P PP      PP  PPLPP
Sbjct: 2406 PPPPPPPPPPPPPPP------PPPPPPLPP 2429



 Score = 31.6 bits (70), Expect = 2.5
 Identities = 45/179 (25%), Positives = 62/179 (34%), Gaps = 24/179 (13%)

Query: 231  PQVGGLPKKSVPQPEFSEAAQTPLWKPQSSEPKRDSSAFPKKASQPPLSDFPKKPPQPEL 290
            P V  LP K  P+P F  ++              D SA P     PP    P  PP P  
Sbjct: 2381 PSVSSLPAK--PRPFFRSSSL-------------DISAQPPPPPPPPPPPPPPPPPPPPP 2425

Query: 291  GDLTRTSSEPEVSVLPKRPRPAEFKALSKKPPQPELGGLPRTSSEPEFNSLPRKLLQPER 350
                 TS +P  ++LPK+         +  P    +  L  T++    N LP   +    
Sbjct: 2426 PLPPPTSPKP--TILPKKKLTVASPVTTATPLFDAVTTL-ETTAVLRSNGLPVTRICTTA 2482

Query: 351  RGPPRKFSQPEPSAVLKRHPQPEFFGDLPRKPPLPSSASESSLPAAVAGFSSRHPLSPG 409
              P        PS ++  H +PE     P KPP+        LP      +  HP   G
Sbjct: 2483 PPPVPPKPSSIPSGLVFTH-RPE-----PSKPPIAPKPVIPQLPTTTQKPTDIHPKPTG 2535



 Score = 30.8 bits (68), Expect = 4.2
 Identities = 51/215 (23%), Positives = 71/215 (33%), Gaps = 37/215 (17%)

Query: 261  EPKRDSSAFPKKASQPPLSDFPKKPPQPELGDLTRTSSEPEVSVLPKRPRPAEFKALSKK 320
            E +R  S+  +     P S     P + +L     TS E      P    P+   ++S  
Sbjct: 2327 EAERTKSSLSETVFDHPPSSVIALPMKEQLSTTYFTSGETFGQEKPASQLPSGSPSVSSL 2386

Query: 321  PPQPELGGLPRTSSEPEFNSLPRKLLQPERRGPPRKFSQPEPSAVLKRHPQPEFFGDLPR 380
            P +P           P F S    +       PP     P P       P P      P 
Sbjct: 2387 PAKPR----------PFFRSSSLDISAQPPPPPPPPPPPPPP-------PPP------PP 2423

Query: 381  KPPLPSSASESSLPAAVAGFSSRHPLS---PGFGAAGTPRWRSGGLVHSGGARPGLR--- 434
             PPLP   S           +   P++   P F A  T    +  ++ S G  P  R   
Sbjct: 2424 PPPLPPPTSPKPTILPKKKLTVASPVTTATPLFDAVTT--LETTAVLRSNGL-PVTRICT 2480

Query: 435  ---PSHPPRRRPLPPASSLGH--PPAKPPLPPGPV 464
               P  PP+   +P      H   P+KPP+ P PV
Sbjct: 2481 TAPPPVPPKPSSIPSGLVFTHRPEPSKPPIAPKPV 2515


>gi|150378539 piccolo isoform 1 [Homo sapiens]
          Length = 5142

 Score = 90.1 bits (222), Expect = 6e-18
 Identities = 141/567 (24%), Positives = 208/567 (36%), Gaps = 99/567 (17%)

Query: 21  KFQASQPEPSDLPKKPPKPEFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPPPEVTDLP 80
           K  A QP P+    KPP  + G  K  +Q    + P KAP P    V  +P P ++   P
Sbjct: 399 KTPAQQPGPA----KPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQ-QPGPGKI---P 450

Query: 81  KKPPPPEVTDLPKKPP--PPEVTDLPKKPPPPEVTDLPKKPSKLELSDLSKKFPQLGATP 138
            +   P  T   +  P  PP     P KPPP +    P KP   +         Q G+T 
Sbjct: 451 AQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPG--PAKPPPQQPGSAKPPSQQPGSTK 508

Query: 139 FPRKPLQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARPPSEPKSGAFPRKLWQPEAG 198
            P  P QP     P K S  +PG+               +PPS+    A P       A 
Sbjct: 509 PP--PQQP----GPAKPSPQQPGS--------------TKPPSQQPGSAKPSAQQPSPAK 548

Query: 199 EATPRSPQPELSTFPKKPAQPEFNVYPKKPPQPQVGGLPKKSVPQPEFSEAAQTPLWKPQ 258
            +  +S +P   T   KP QP   V P    QP   GLPK   P        +  L  P+
Sbjct: 549 PSAQQSTKPVSQTGSGKPLQPP-TVSP-SAKQPPSQGLPKTICP---LCNTTELLLHVPE 603

Query: 259 SSEPKRDSSAFPKKASQPPLSDFPKKPPQPEL---------------GDLTRTSSEPEVS 303
            +     +       S   L  F   P   E+               GDL    S P+  
Sbjct: 604 KANFNTCTECQTTVCS---LCGFNPNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPK 660

Query: 304 VLPKRPRPAEFKALSKKPPQPELGGLPRTSSEPEFNSLPRKLLQ--PERRGPPRKFSQP- 360
           +  K        A+SK  PQP+        + P+ ++ P++ L   PE + PP    QP 
Sbjct: 661 L--KTAPVTTTSAVSKSSPQPQ-------QTSPKKDAAPKQDLSKAPEPKKPPPLVKQPT 711

Query: 361 ---EPSAVLKRHPQPEFFGDLPRKPPLPSSASESSLPAAVAGFSSRHP--LSPGFGAAGT 415
               PSA  K+ P+ +     P  P  PS  SE    A VA    + P  + P       
Sbjct: 712 LHGSPSAKAKQPPEADSLSK-PAPPKEPSVPSEQD-KAPVADDKPKQPKMVKP------- 762

Query: 416 PRWRSGGLVHSGGAR-----PGLRPSHPPRRRPLPPASSLGHPPAKPPLPPG----PVDM 466
               +  LV S  A      P  +       +  PP  +    P++   P G    P D 
Sbjct: 763 ----TTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDS 818

Query: 467 QSFRRPSAASIDLRRTRSAAGLHFQDRQPEDIPVPDEIYELYDDVEPRDDSSPSPKGRDE 526
           ++  RP++ S  +     ++    Q +Q + +   +E  +    + P+ D+ P PKG   
Sbjct: 819 KAIPRPASDSKIISHPGPSSESKGQ-KQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPT 877

Query: 527 APSVQQAARRPPQDPALRKEKDPQPQQ 553
            P  +  A +    P    ++ P+PQ+
Sbjct: 878 PPGPRPTAGQTVPTP----QQSPKPQE 900



 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 139/574 (24%), Positives = 209/574 (36%), Gaps = 96/574 (16%)

Query: 25  SQP----EPSDLPKKPPKPEFGKL---KKFSQPELSEHPKKAPLPEFGAVSLKPPPPEVT 77
           SQP    +P   P + P+ +  KL   +  S+P+     K+A +      S+KP  P   
Sbjct: 249 SQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQT----KQADIVR--GESVKPSLPS-- 300

Query: 78  DLPKKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPSKLELSDLSKKFPQLGAT 137
             P KPP  + T  P KPP  +      +P P +    P +PS      L+K   Q   T
Sbjct: 301 --PSKPPIQQPT--PGKPPAQQPGHEKSQPGPAKP---PAQPS-----GLTKPLAQQPGT 348

Query: 138 PFPRKPLQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARPPSEPKSGAFPRKLWQPEA 197
             P  P+QP     P      +P  PA+ P Q      P+     PK+ A P  + +  A
Sbjct: 349 VKP--PVQPPGTTKPPA----QPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPA 402

Query: 198 GEATPRSPQPELSTFPKKPAQPEFNVYPKKPPQPQVGGLPKKSVPQPE----FSEAAQTP 253
            +  P  P  +    PK  AQ      P K P P      K  V QP      ++ A   
Sbjct: 403 QQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGP-----TKTPVQQPGPGKIPAQQAGPG 457

Query: 254 LWKPQSSEPKRDSSAFPKKASQPPLSDFPKKPPQPELGDLTRTSSEP-EVSVLPKRPRPA 312
               Q + P +  S  P  A  PP    P KPP  + G     S +P      P++P PA
Sbjct: 458 KTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPA 517

Query: 313 E---FKALSKKPPQPELGGL-------------PRTSSEPEFNSLPRKLLQPERRGPPRK 356
           +    +  S KPP  + G                + S++P   +   K LQP    P  K
Sbjct: 518 KPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAK 577

Query: 357 F--SQPEPSAVLKRHPQPEFFGDLPRKPPLPSSASESSLPAAVAGFSSRHPLSPGFGAAG 414
              SQ  P  +       E    +P K    +     +   ++ GF+    L+       
Sbjct: 578 QPPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFNPNPHLTE------ 631

Query: 415 TPRW--RSGGLVHSGGARPGLRPSHPPRRRPLPPASSLGHPPAKPPLPPGPVDMQSFRRP 472
              W   +  +  + G      PS P  +    P ++        P P       S ++ 
Sbjct: 632 VKEWLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQP----QQTSPKKD 687

Query: 473 SAASIDLRRTRSAAGLHFQDRQPEDIPVPDEIYELYDDVEPRDDSSPSPKGRD--EAPSV 530
           +A   DL             + PE    P  +       +P    SPS K +   EA S+
Sbjct: 688 AAPKQDL------------SKAPEPKKPPPLV------KQPTLHGSPSAKAKQPPEADSL 729

Query: 531 QQAARRPPQDPALRKEKDPQP-QQLPPMDPKLLK 563
            + A  PP++P++  E+D  P     P  PK++K
Sbjct: 730 SKPA--PPKEPSVPSEQDKAPVADDKPKQPKMVK 761



 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 81/345 (23%), Positives = 127/345 (36%), Gaps = 36/345 (10%)

Query: 30  SDLPKKPPKPEFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPPPEVTDLPKKPPPPEVT 89
           S + K  P+P+    KK + P+  +   KAP P+     +K P    +   K   PPE  
Sbjct: 670 SAVSKSSPQPQQTSPKKDAAPK--QDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEAD 727

Query: 90  DLPKKPPPPEVTDLPKKPPPPEVTDLPKKPSKLE-LSDLSKKFPQLGATPFPRKPLQPEV 148
            L K  PP E +   ++   P   D PK+P  ++  +DL            P   +Q + 
Sbjct: 728 SLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQA 787

Query: 149 GE---APLKASLPEPG---APARKPLQPDELSHPARPPSEPKSGAFPRKLWQPEAGEATP 202
            E    PLK    +P     P  + + P +     RP S+ K  + P        G ++ 
Sbjct: 788 EEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHP--------GPSSE 839

Query: 203 RSPQPELSTFPKK--PAQPEFNVYPKKPPQPQVGGLPKKSVPQPEFSEAAQTPLWKPQSS 260
              Q ++    KK  P + +  + PK   +P   G P    P+P   +   TP    QS 
Sbjct: 840 SKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPTP---QQSP 896

Query: 261 EPKRDSSAFPKKASQPPLSDFPKKPPQPELGDLTRTSSEPEVSVLPKRPRPAEFKALSKK 320
           +P+  S  F        ++D PK  P      +T        S+       ++   L   
Sbjct: 897 KPQEQSRRFSLNLGS--ITDAPKSQPTTPQETVTGKLFGFGASIF------SQASNLIST 948

Query: 321 PPQPELGGLPRTSSEP--EFNSLPRKLLQPERRGPPRKFSQPEPS 363
             QP     P + S P       P     P  +GPP+   Q  P+
Sbjct: 949 AGQPG----PHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPA 989



 Score = 67.0 bits (162), Expect = 5e-11
 Identities = 116/516 (22%), Positives = 174/516 (33%), Gaps = 131/516 (25%)

Query: 69   LKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPSKLELSDLS 128
            L P P       K  P    + + K  P P+ T  PKK   P+              DLS
Sbjct: 650  LAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTS-PKKDAAPK-------------QDLS 695

Query: 129  KKFPQLGATPFPRKPLQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARPPSEPKSGAF 188
            K        P P+KP  P V +  L  S   P A A++P + D LS PA PP EP     
Sbjct: 696  K-------APEPKKP-PPLVKQPTLHGS---PSAKAKQPPEADSLSKPA-PPKEP----- 738

Query: 189  PRKLWQPEAGEATPRSPQPELSTFPKKPAQPEFNVYPKKPPQPQVGGLPKKSVPQPEFSE 248
                        +  S Q +      KP QP+  V P            K  +P  +   
Sbjct: 739  ------------SVPSEQDKAPVADDKPKQPKM-VKPTTDLVSSSSATTKPDIPSSKVQS 785

Query: 249  AAQ---TPLWKPQSSEPKR------------DSSAFPKKASQPPLSDFPKKPPQPELGDL 293
             A+   TP  K  S++P +            DS A P+ AS   +   P        G  
Sbjct: 786  QAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHP--------GPS 837

Query: 294  TRTSSEPEVSVLPKRPRPAEFKALSKKPPQPELGGLPRTSSEPEFNSLPRKLLQPERRGP 353
            + +  + +V  + K+  P   KA +K  P+P+   +P+ S  P               GP
Sbjct: 838  SESKGQKQVDPVQKKEEPK--KAQTKMSPKPDAKPMPKGSPTPP--------------GP 881

Query: 354  PRKFSQPEPSAVLKRHPQPEF------FGDLPRKPPLPSSASESSLPAAVAGFSSR--HP 405
                 Q  P+      PQ +        G +   P    +  + ++   + GF +     
Sbjct: 882  RPTAGQTVPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQ 941

Query: 406  LSPGFGAAGTPRWRSGGLVHSGGARPGLRPSHPPRRRPLP--PASSLGHPPAKPPLPPGP 463
             S     AG P           G      P  P ++ P P  P +S G P +    PP P
Sbjct: 942  ASNLISTAGQP-----------GPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAP 990

Query: 464  VDMQSFRRPSAASIDLRRTRSAAGLHFQDRQPEDIPVPDEIYELYDDVEPRDDSSPSPKG 523
                      A SI +++   A      + + E  P           V+  +     P  
Sbjct: 991  ----------AKSIPVKKETKAPAAEKLEPKAEQAPT----------VKRTETEKKPPPI 1030

Query: 524  RDEAPSVQQAARRPPQDPAL--RKEKDPQPQQLPPM 557
            +D      ++    PQ   L  + EK P+P+   P+
Sbjct: 1031 KD-----SKSLTAEPQKAVLPTKLEKSPKPESTCPL 1061



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 79/297 (26%), Positives = 109/297 (36%), Gaps = 70/297 (23%)

Query: 41   FGKLKKFSQ-----PELSEHPKKAPLPEFGAVSLKPPPPEVTDLPKKPPPPEVTDLPKKP 95
            FG+ K  SQ     P +S  P K P P F + SL        D+  +PPPP        P
Sbjct: 2367 FGQEKPASQLPSGSPSVSSLPAK-PRPFFRSSSL--------DISAQPPPPP------PP 2411

Query: 96   PPPEVTDLPKKPPPPEVTDLPKKPSKLELSDLSKKFPQLGATPFPRKPLQPEVGEAPLKA 155
            PPP     P  PPPP       KP+ L    L+   P   AT     PL   V      A
Sbjct: 2412 PPPPPPPPPPPPPPPLPPPTSPKPTILPKKKLTVASPVTTAT-----PLFDAVTTLETTA 2466

Query: 156  SLPEPGAPARKPLQPDELSHPARPPSEPKSGAFPRKLW-----QPEAGEATPRSPQPELS 210
             L   G P  +      +   A PP  PK  + P  L      +P      P+   P+L 
Sbjct: 2467 VLRSNGLPVTR------ICTTAPPPVPPKPSSIPSGLVFTHRPEPSKPPIAPKPVIPQLP 2520

Query: 211  TFPKKPAQPEFNVYPK--------------------KPPQPQVGGLPKKSVPQPEFSEA- 249
            T  +KP     +++PK                    K P P     P  +   P FS++ 
Sbjct: 2521 TTTQKPT----DIHPKPTGLSLTSSMTLNLVTSADYKLPSPTSPLSPHSNKSSPRFSKSL 2576

Query: 250  AQTPLWKPQSSEPKRDSSAFPKKASQPPLSDFPKKPPQPELGDLTRTSSEPEVSVLP 306
             +T +     SEP   + +   +A    ++ +P   P  +L      S EP  SV+P
Sbjct: 2577 TETYVVITLPSEPGTPTDSSASQA----ITSWPLGSPSKDL-----VSVEPVFSVVP 2624



 Score = 56.2 bits (134), Expect = 9e-08
 Identities = 132/570 (23%), Positives = 201/570 (35%), Gaps = 84/570 (14%)

Query: 6   PAAMESHQDFRSIKAKFQASQP-EPSDLPKKPPKPEFGKLKKFSQPELSEHPKKAPLPEF 64
           PAA ES    R  K +  +S P + S  P  P +P    L K    +     +K P    
Sbjct: 73  PAAAESPSMHR--KQELDSSHPPKQSGRPPDPGRPAQPGLSKSRTTDTFRSEQKLPGRSP 130

Query: 65  GAVSLKPPPPEVTDLPKKPPPPEVTD-LPKKPPPPEVTDLPKKPPPPEVTDLPKKPSKLE 123
             +SLK      TDL ++     +   L +      V+ +  K  P ++     + S+ E
Sbjct: 131 STISLKESKSR-TDLKEEHKSSMMPGFLSEVNALSAVSSVVNKFNPFDLIS-DSEASQEE 188

Query: 124 LSDLSKKFPQLGATPFPRKPLQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARPPSEP 183
            +   K   +    P     ++P + + P K  +P+   P R PLQ D       P S  
Sbjct: 189 TTKKQKVVQKEQGKP--EGIIKPPLQQQPPKP-IPKQQGPGRDPLQQD-----GTPKSIS 240

Query: 184 KSGAFPRKLWQPEAGEATPRSPQPELSTFPKKPAQPEFNVYPKKPPQPQVGGLPKKSVPQ 243
                  K   P  G+      Q   +   K P Q + +    K      G   K S+P 
Sbjct: 241 SQQPEKIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPS 300

Query: 244 PEFSEAAQTPLWKPQSSEPKRDSSAFPKKASQPPLSDFPKKPPQPELGDLTRTSSEPEVS 303
           P      Q    KP + +P  +        SQP     P KPP    G LT+  ++   +
Sbjct: 301 PSKPPIQQPTPGKPPAQQPGHEK-------SQPG----PAKPPAQPSG-LTKPLAQQPGT 348

Query: 304 VLPKRPRPAEFKALSK-----KPPQPELGGLPRTSSEPEFNSLPRKLLQPERRG--PPRK 356
           V P    P   K  ++     KPP  + G    +S +P     P+ L QP   G  P ++
Sbjct: 349 VKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPG----PKALAQPPGVGKTPAQQ 404

Query: 357 FSQPEPSAVLKRHPQPEFFGDLPRKPPLPSSASESSLPAAVAGFSSRHPLSPGFGAAGTP 416
               +P       P+P     L ++P L S       PA   G +      PG       
Sbjct: 405 PGPAKPPTQQVGTPKP-----LAQQPGLQS-------PAKAPGPTKTPVQQPG------- 445

Query: 417 RWRSGGLVHSGGARPGLRPSHPPRRRPLPPASSLGHPPAKPPLPPGPVDMQSFRRPSAAS 476
                G + +  A PG   +   +  P  P S L  P   PP  PGP      ++P +A 
Sbjct: 446 ----PGKIPAQQAGPG--KTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPP-QQPGSAK 498

Query: 477 IDLRRTRSAAGLHFQDRQPEDIPVPDEIYELYDDVEPRDDSSPSPKGRDEAPSVQQAARR 536
              ++  S        + P   P P +        +P     PS +     PS QQ +  
Sbjct: 499 PPSQQPGST-------KPPPQQPGPAK----PSPQQPGSTKPPSQQPGSAKPSAQQPS-- 545

Query: 537 PPQDPALRKEKDP-------QPQQLPPMDP 559
            P  P+ ++   P       +P Q P + P
Sbjct: 546 -PAKPSAQQSTKPVSQTGSGKPLQPPTVSP 574



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 92/400 (23%), Positives = 137/400 (34%), Gaps = 95/400 (23%)

Query: 235 GLPKKSVPQPEFSEAAQTPLWKPQSSEPKRDSSAFPKKASQPPLSDFPKKPPQPELGDLT 294
           GLPK SVP      AA++P       + + DSS  PK++ +PP    P +P QP L    
Sbjct: 65  GLPKGSVP----PAAAESP---SMHRKQELDSSHPPKQSGRPP---DPGRPAQPGLSKSR 114

Query: 295 RTSS----------EPEVSVLPKRPRPAEFKALSKKPPQP----ELGGLPRTSS------ 334
            T +           P    L +     + K   K    P    E+  L   SS      
Sbjct: 115 TTDTFRSEQKLPGRSPSTISLKESKSRTDLKEEHKSSMMPGFLSEVNALSAVSSVVNKFN 174

Query: 335 ----------EPEFNSLPRKLLQPERRGPPRKFSQPEPSAVLKRHPQPEFFGDLPRKPPL 384
                       E  +  +K++Q E +G P    +P    + ++ P+P      P + PL
Sbjct: 175 PFDLISDSEASQEETTKKQKVVQKE-QGKPEGIIKP---PLQQQPPKPIPKQQGPGRDPL 230

Query: 385 PSSASESSLPAAVAGFSSRHPLSPGFGA---------------------AGTPRWRSGGL 423
               +  S+ +         P  PG G                      A  P+ +   +
Sbjct: 231 QQDGTPKSISSQQPEKIKSQP--PGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADI 288

Query: 424 VHSGGARPGL-RPSHPPRRRPL---PPASSLGHP-----PAKPPLPPGPVDMQSFRRPSA 474
           V     +P L  PS PP ++P    PPA   GH      PAKPP  P  +     ++P  
Sbjct: 289 VRGESVKPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGT 348

Query: 475 ASIDLR---RTRSAAGLHFQDRQPEDIPVPDEIYELYDDVEPRDDSSPSPKGRDEAPSVQ 531
               ++    T+  A    Q   P   P      E     +P   +   P G  + P+ Q
Sbjct: 349 VKPPVQPPGTTKPPA----QPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQ 404

Query: 532 QAARRPP-----------QDPALRK-EKDPQPQQLPPMDP 559
               +PP           Q P L+   K P P + P   P
Sbjct: 405 PGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQP 444



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 85/407 (20%), Positives = 145/407 (35%), Gaps = 61/407 (14%)

Query: 31   DLPKKPPKPEFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPPPEVTDLPKKPPPPEVTD 90
            D  +K  +P+  + K   +P+    PK +P P       +P   +    P++ P P+   
Sbjct: 847  DPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPP----GPRPTAGQTVPTPQQSPKPQEQS 902

Query: 91   LPKKPPPPEVTDLPK-KPPPPEVTDLPK----------KPSKLELSDLSKKFPQLGATP- 138
                     +TD PK +P  P+ T   K          + S L +S   +  P   + P 
Sbjct: 903  RRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNL-ISTAGQPGPHSQSGPG 961

Query: 139  FPRK----PLQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARPPSEPKSGAFPRKLWQ 194
             P K    P QP   + P K++   P APA+      E   PA    EPK+   P     
Sbjct: 962  APMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEKLEPKAEQAPTVKRT 1021

Query: 195  PEAGEATPRSPQPELSTFPKKPAQP------------------EFNVYPKKPPQPQVGGL 236
                +  P      L+  P+K   P                  E N+  K PP       
Sbjct: 1022 ETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPKPESTCPLCKTELNIGSKDPPNFNTCTE 1081

Query: 237  PKKSV-------PQPEFSEAAQTPLWKPQSSEPKRD-SSAFPKKASQPPLSDFPKKPPQP 288
             K  V       P P  +E  +   W   + + +R  S         PP    PK  P P
Sbjct: 1082 CKNQVCNLCGFNPTPHLTEIQE---WLCLNCQTQRAISGQLGDIRKMPPAPSGPKASPMP 1138

Query: 289  ELGDLT--RTSSEPEVSVLPKRPRPAEFKALSKKPPQPELGGLPRTSSEPEFNSLPRKLL 346
               + +  +T+  P+V ++ K+ +  + +A        E   L +         +P  ++
Sbjct: 1139 VPTESSSQKTAVPPQVKLVKKQEQEVKTEA--------EKVILEKVKETLSMEKIP-PMV 1189

Query: 347  QPERRGPPRKFSQPEPSAVLKRHPQPEFFGDLPRKPPLPSSASESSL 393
              +++    K  + + SA+ ++ P PE    +P +  + S   +  L
Sbjct: 1190 TTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEEKIRSEEKKPLL 1236



 Score = 37.0 bits (84), Expect = 0.059
 Identities = 60/235 (25%), Positives = 81/235 (34%), Gaps = 57/235 (24%)

Query: 108  PPPEVTDLPKKPSKLELSDLSKKFPQLGATPFPRKPLQPEVGEAPLKASLPEPGAPARKP 167
            PP  V  LP K        LS  +   G T    KP       +P  +SLP    P  + 
Sbjct: 2343 PPSSVIALPMK------EQLSTTYFTSGETFGQEKPASQLPSGSPSVSSLPAKPRPFFRS 2396

Query: 168  LQPDELSHPARPPSEPKSGAFPRKLWQPEAGEATPRSPQPELSTFPKKPAQPEFNVYPKK 227
               D  + P  PP  P           P      P  P P L      P  P+  + PKK
Sbjct: 2397 SSLDISAQPPPPPPPP-----------PPPPPPPPPPPPPPL----PPPTSPKPTILPKK 2441

Query: 228  PPQPQVGGLPKKSVPQPEFSEAAQTPLWKPQSSEPKRDSSAFPKKASQPP----LSDFPK 283
                      K +V  P       TPL+   ++    +++A  +    P      +  P 
Sbjct: 2442 ----------KLTVASP---VTTATPLFDAVTT---LETTAVLRSNGLPVTRICTTAPPP 2485

Query: 284  KPPQPELGDLTRTSSEPEVSVLPKRPRPAEFKALSKKP--PQPELGGLPRTSSEP 336
             PP+P        SS P   V   RP P      SK P  P+P +  LP T+ +P
Sbjct: 2486 VPPKP--------SSIPSGLVFTHRPEP------SKPPIAPKPVIPQLPTTTQKP 2526



 Score = 32.0 bits (71), Expect = 1.9
 Identities = 28/100 (28%), Positives = 43/100 (43%), Gaps = 8/100 (8%)

Query: 478  DLRRTRSAAGLHFQDRQPEDIPVPDEIYELYDDVEPRDDSSPSPKGRDEAPSVQQAARRP 537
            D  R   ++ LH     P   P    +  L +D     DSSPS K  +     Q+ AR  
Sbjct: 1710 DRSRGEGSSSLHASSFTPGTSPT--SVSSLDED----SDSSPSHKKGESKQ--QRKARHR 1761

Query: 538  PQDPALRKEKDPQPQQLPPMDPKLLKQLRKAEKAEREFRK 577
            P  P L   +D   ++    + +LLK+  K  + E++ RK
Sbjct: 1762 PHGPLLPTIEDSSEEEELREEEELLKEQEKQREIEQQQRK 1801



 Score = 31.6 bits (70), Expect = 2.5
 Identities = 33/90 (36%), Positives = 35/90 (38%), Gaps = 26/90 (28%)

Query: 373  EFFGDLPRKPPLPS-SASESSLPAAVAGFSSRHPLSPGFGAAGTPRWRSGGLVHSGGARP 431
            E FG       LPS S S SSLPA    F                 +RS  L  S  A+P
Sbjct: 2365 ETFGQEKPASQLPSGSPSVSSLPAKPRPF-----------------FRSSSLDIS--AQP 2405

Query: 432  GLRPSHPPRRRPLPPASSLGHPPAKPPLPP 461
               P  PP   P PP      PP  PPLPP
Sbjct: 2406 PPPPPPPPPPPPPPP------PPPPPPLPP 2429



 Score = 31.6 bits (70), Expect = 2.5
 Identities = 45/179 (25%), Positives = 62/179 (34%), Gaps = 24/179 (13%)

Query: 231  PQVGGLPKKSVPQPEFSEAAQTPLWKPQSSEPKRDSSAFPKKASQPPLSDFPKKPPQPEL 290
            P V  LP K  P+P F  ++              D SA P     PP    P  PP P  
Sbjct: 2381 PSVSSLPAK--PRPFFRSSSL-------------DISAQPPPPPPPPPPPPPPPPPPPPP 2425

Query: 291  GDLTRTSSEPEVSVLPKRPRPAEFKALSKKPPQPELGGLPRTSSEPEFNSLPRKLLQPER 350
                 TS +P  ++LPK+         +  P    +  L  T++    N LP   +    
Sbjct: 2426 PLPPPTSPKP--TILPKKKLTVASPVTTATPLFDAVTTL-ETTAVLRSNGLPVTRICTTA 2482

Query: 351  RGPPRKFSQPEPSAVLKRHPQPEFFGDLPRKPPLPSSASESSLPAAVAGFSSRHPLSPG 409
              P        PS ++  H +PE     P KPP+        LP      +  HP   G
Sbjct: 2483 PPPVPPKPSSIPSGLVFTH-RPE-----PSKPPIAPKPVIPQLPTTTQKPTDIHPKPTG 2535



 Score = 30.8 bits (68), Expect = 4.2
 Identities = 51/215 (23%), Positives = 71/215 (33%), Gaps = 37/215 (17%)

Query: 261  EPKRDSSAFPKKASQPPLSDFPKKPPQPELGDLTRTSSEPEVSVLPKRPRPAEFKALSKK 320
            E +R  S+  +     P S     P + +L     TS E      P    P+   ++S  
Sbjct: 2327 EAERTKSSLSETVFDHPPSSVIALPMKEQLSTTYFTSGETFGQEKPASQLPSGSPSVSSL 2386

Query: 321  PPQPELGGLPRTSSEPEFNSLPRKLLQPERRGPPRKFSQPEPSAVLKRHPQPEFFGDLPR 380
            P +P           P F S    +       PP     P P       P P      P 
Sbjct: 2387 PAKPR----------PFFRSSSLDISAQPPPPPPPPPPPPPP-------PPP------PP 2423

Query: 381  KPPLPSSASESSLPAAVAGFSSRHPLS---PGFGAAGTPRWRSGGLVHSGGARPGLR--- 434
             PPLP   S           +   P++   P F A  T    +  ++ S G  P  R   
Sbjct: 2424 PPPLPPPTSPKPTILPKKKLTVASPVTTATPLFDAVTT--LETTAVLRSNGL-PVTRICT 2480

Query: 435  ---PSHPPRRRPLPPASSLGH--PPAKPPLPPGPV 464
               P  PP+   +P      H   P+KPP+ P PV
Sbjct: 2481 TAPPPVPPKPSSIPSGLVFTHRPEPSKPPIAPKPV 2515


>gi|41349482 proline-rich protein BstNI subfamily 1 isoform 1
           preproprotein [Homo sapiens]
          Length = 331

 Score = 89.0 bits (219), Expect = 1e-17
 Identities = 95/336 (28%), Positives = 133/336 (39%), Gaps = 59/336 (17%)

Query: 50  PELSEHPKKAPLPEFGAVSLKPPPPEVTDLPKKP--PPPEVTDLPKKPPPPEVTDLPKKP 107
           P L     + P P+ G     PPPP     P KP  PPP+  + P+ PPPP     P+ P
Sbjct: 29  PSLIAGNPQGPSPQGGNKPQGPPPP-----PGKPQGPPPQGGNKPQGPPPP---GKPQGP 80

Query: 108 PPP-EVTDLPKKPSKLELSDLSKKFPQ-LGATPFPRKPLQPEVGEAPLKASLPEPGAPAR 165
           PP  + +  P+ P         +   Q  G  P P KP  P           P PG P  
Sbjct: 81  PPQGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNRPQGPPPPGKPQG 140

Query: 166 KPLQPDELSHPARPPSEPKSGAFPRKLWQPEAGEATPRSPQPELSTFPKKPA--QPEFNV 223
            P Q D+   P  PP +P+          P  G   P+ P P     P KP    P+   
Sbjct: 141 PPPQGDKSRSPRSPPGKPQG--------PPPQGGNQPQGPPPP----PGKPQGPPPQGGK 188

Query: 224 YPKKPPQPQVGGLPKKSVPQPEFSEAAQTPLWKPQSSEPKRDSSAF-----PKKASQPPL 278
            P+ PP P   G P+   PQ + S ++Q+P  KPQ   P+  +        P K   PP 
Sbjct: 189 KPQGPPPP---GKPQGPPPQGDKSRSSQSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPP 245

Query: 279 --SDFPKKPPQP--------ELGDLTRTSSEPEVSVLPKRPR-PAEFKALSKKPPQPELG 327
              + P+ PP P        + G  ++++  P     P +P+ P + +  + + P P  G
Sbjct: 246 QGGNKPQGPPPPGKPQGPPAQGGSKSQSARSP-----PGKPQGPPQQEGNNPQGPPPPAG 300

Query: 328 GLPRTSSEPEFNSLPRKLLQPERRGPPRKFSQPEPS 363
           G P+    P          QP+  GPPR      PS
Sbjct: 301 GNPQQPQAPPAG-------QPQ--GPPRPPQGGRPS 327



 Score = 76.3 bits (186), Expect = 9e-14
 Identities = 82/293 (27%), Positives = 109/293 (37%), Gaps = 43/293 (14%)

Query: 21  KFQASQPEPSDLPKKPPKPEFGKLK-KFSQPELSEHPKKAPLPEFGAVSLKPPPPEVTDL 79
           K Q   P+  + P+ PP P  GK +    Q + S  P+  P    G      PPP+  + 
Sbjct: 56  KPQGPPPQGGNKPQGPPPP--GKPQGPPPQGDKSRSPRSPPGKPQG------PPPQGGNQ 107

Query: 80  PKKPPPPEVTDLPKKP--PPPEVTDLPKKPPPPEVTDLPKKPSKLELSDLSK-------- 129
           P+ PPPP     P KP  PPP+  + P+ PPPP     P        S  S         
Sbjct: 108 PQGPPPP-----PGKPQGPPPQGGNRPQGPPPPGKPQGPPPQGDKSRSPRSPPGKPQGPP 162

Query: 130 ----KFPQLGATPFPRKPLQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARPPSEPKS 185
                 PQ G  P P KP  P           P PG P   P Q D+      PP +P+ 
Sbjct: 163 PQGGNQPQ-GPPPPPGKPQGPPPQGGKKPQGPPPPGKPQGPPPQGDKSRSSQSPPGKPQ- 220

Query: 186 GAFPRKLWQPEAGEATPRSPQPELSTFPKKPAQPEFNVYPKKPPQPQVGGLPKKSV---- 241
           G  P+   QP+     P  PQ        KP  P     P+ PP    GG   +S     
Sbjct: 221 GPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPAQ--GGSKSQSARSPP 278

Query: 242 --PQPEFSEAAQTPLWKPQSS-----EPKRDSSAFPKKASQPPLSDFPKKPPQ 287
             PQ    +    P   P  +     +P+   +  P+   +PP    P +PPQ
Sbjct: 279 GKPQGPPQQEGNNPQGPPPPAGGNPQQPQAPPAGQPQGPPRPPQGGRPSRPPQ 331



 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 99/401 (24%), Positives = 142/401 (35%), Gaps = 128/401 (31%)

Query: 67  VSLKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKP--PPPEVTDLPKKPSKLEL 124
           VS +  P  +   P+ P P +  + P+ PPPP     P KP  PPP+  + P+ P     
Sbjct: 23  VSQEESPSLIAGNPQGPSP-QGGNKPQGPPPP-----PGKPQGPPPQGGNKPQGP----- 71

Query: 125 SDLSKKFPQLGATPFPRKPLQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARPPSEPK 184
                                            P PG P   P Q D+   P  PP +P+
Sbjct: 72  ---------------------------------PPPGKPQGPPPQGDKSRSPRSPPGKPQ 98

Query: 185 SGAFPRKLWQPEAGEATPRSPQPELSTFPKKPA--QPEFNVYPKKPPQPQVGGLPKKSVP 242
                     P  G   P+ P P     P KP    P+    P+ PP P   G P+   P
Sbjct: 99  G--------PPPQGGNQPQGPPPP----PGKPQGPPPQGGNRPQGPPPP---GKPQGPPP 143

Query: 243 QPEFSEAAQTPLWKPQSSEPKRDSSAFPKKASQPPLSDFPKKPPQPELGDLTRTSSEPEV 302
           Q + S + ++P  KPQ   P+  +    +    PP    P+ PP P+ G   +    P  
Sbjct: 144 QGDKSRSPRSPPGKPQGPPPQGGN----QPQGPPPPPGKPQGPP-PQGG---KKPQGPPP 195

Query: 303 SVLPKRPRPAEFKALSKK-PPQPELGGLPRTSSEPEFNSLPRKLLQPERRGPPRKFSQPE 361
              P+ P P   K+ S + PP    G  P+  ++P+              GPP    +P+
Sbjct: 196 PGKPQGPPPQGDKSRSSQSPPGKPQGPPPQGGNQPQ--------------GPPPPPGKPQ 241

Query: 362 PSAVLKRHPQPEFFGDLPRKPPLPSSASESSLPAAVAGFSSRHPLSPGFGAAGTPRWRSG 421
                   P P+  G+ P+ PP P        P A  G  S+   SP             
Sbjct: 242 G-------PPPQG-GNKPQGPPPPGKPQG---PPAQGGSKSQSARSP------------- 277

Query: 422 GLVHSGGARPGLRPSHPPRRRPLPPASSLGHPPAKPPLPPG 462
                    PG +P  PP++         G+ P  PP P G
Sbjct: 278 ---------PG-KPQGPPQQE--------GNNPQGPPPPAG 300



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 64/280 (22%), Positives = 96/280 (34%), Gaps = 20/280 (7%)

Query: 292 DLTRTSSEPEVSVLPKRPRPAEFKALSKKPPQP--ELGGLPRTSSEPEFNSLPRKLLQPE 349
           D+++  S   ++  P+ P P         PP P    G  P+  ++P+    P K   P 
Sbjct: 22  DVSQEESPSLIAGNPQGPSPQGGNKPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPP 81

Query: 350 RRGPPRKFSQPEPSAVLKRHPQPEFFGDLPRKPPLPSSASESSLPAAVAGFSSRHPLSPG 409
            +G   +  +  P    K    P   G+ P+ PP P    +   P    G   + P  PG
Sbjct: 82  PQGDKSRSPRSPPG---KPQGPPPQGGNQPQGPPPPPGKPQG--PPPQGGNRPQGPPPPG 136

Query: 410 FGAAGTPRWRSGGLVHSGGARPGLRP---SHPPRRRPLPPASSLGHPPAKPPLPPGPVDM 466
                 P+        S   +P   P    + P+  P PP    G PP     P GP   
Sbjct: 137 KPQGPPPQGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGKKPQGPPPP 196

Query: 467 QSFRRPSAASIDLRRTRSAAGL-----HFQDRQPEDIPVPDEIYELYDDVEPRDDSSPSP 521
              + P       R ++S  G           QP+  P P    +            P P
Sbjct: 197 GKPQGPPPQGDKSRSSQSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPP 256

Query: 522 KGRDEAPSVQ-----QAARRPPQDPALRKEKDPQPQQLPP 556
            G+ + P  Q     Q+AR PP  P    +++    Q PP
Sbjct: 257 PGKPQGPPAQGGSKSQSARSPPGKPQGPPQQEGNNPQGPP 296


>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 855

 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 131/492 (26%), Positives = 168/492 (34%), Gaps = 111/492 (22%)

Query: 19  KAKFQASQPEPSDLPKKPPKPEFGKLKKFSQPEL---SEHPKKAPLPEFGAVSLKPPPPE 75
           +A    SQP+P  L    P P+    +K + P L   S  P   P P     S  PP   
Sbjct: 264 RAPAHPSQPKPKGLQALRP-PQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLP 322

Query: 76  VTD------------LPKKPP----PPEVTDLPKKP--PPPEVTD-------------LP 104
            T             LP  PP    PP +  LP  P  PP + T              LP
Sbjct: 323 ATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLP 382

Query: 105 KKPPPPEVTDLPKKPSKLELSDLS-----KKFPQLG--ATPFPRKP--LQPEVGEAPLKA 155
             P  P  T  P+ P  L L  L         P L   ATP P+ P  L   + +AP   
Sbjct: 383 SPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFS- 441

Query: 156 SLPEPGAPARKPLQPDELSHPARPPSEPKSGAFPRKLWQPEAGEATPRSPQPELSTFPKK 215
             P P  P + P  P     PA PP  P +             +A P    P L   P  
Sbjct: 442 --PPPSPPVQAPFSP-----PASPPVSPSA---------TPPSQAPPSLAAPPLQVPPSP 485

Query: 216 PAQPEFNVYPKKPPQ--PQVGGLP-KKSVPQPEFSEAAQTPLWKPQSSEPKRDSSAFPKK 272
           PA P  +     PPQ  P +   P + + P P+   A  TP  +   S P    ++FP +
Sbjct: 486 PASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPP----ASFPGQ 541

Query: 273 ASQPPLSDFPKKPPQPELGDLTRTSSEPEVSVLPKRPRPAEFKALSKKPPQPELGGLPRT 332
           A   P +  P  P                ++  P +  P     L + PP P        
Sbjct: 542 APFSPSASLPMSP----------------LATPPPQAPPVLAAPLLQVPPSP-------- 577

Query: 333 SSEPEFNSLPRKLLQPERRGPPRKFSQPEPSAVLKRHPQPEFFGDLPRKPPLPSSASESS 392
            + P   + PR+   P   GP    S P  +  L            P  PP PS +  S+
Sbjct: 578 PASPTLQA-PRR---PPTPGPDTSVSGPRLTLAL-----------APGPPPPPSRSPSST 622

Query: 393 LPAA-VAGFSSRHPLSPGFGAAGTPRWRSGGLVHSGGARPGLRPSHPP--RRRPLPPASS 449
           L    +AG SS    +P     G      GG   S      L   HP    R P PP + 
Sbjct: 623 LSGPDLAGHSSSATSTPE-ELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAF 681

Query: 450 LGHPPAKPPLPP 461
            G P A  P PP
Sbjct: 682 RGAPGAPLPWPP 693



 Score = 67.4 bits (163), Expect = 4e-11
 Identities = 115/441 (26%), Positives = 166/441 (37%), Gaps = 63/441 (14%)

Query: 140 PRKPLQPEVGEAPLKAS-LPEPGAPARKPLQ--PDELSHPARPPSEPKSGAFPRKLWQPE 196
           P K   P    +P +AS    PG   +K L+   +E     +    PK  A      +  
Sbjct: 105 PAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDT 164

Query: 197 AGEATPRSPQPELSTFPKKPAQPEFNV---YPKKPPQPQVGGLPKKSVPQPEFSEAAQTP 253
           +G  TP +P P ++    + A  E  +    P   P+P   G P+KSV     S A++  
Sbjct: 165 SGP-TPGTPSPAMAR-RSRAAGTEVGLPRPAPSARPRPPTEG-PRKSV-----SSASEHS 216

Query: 254 LWKPQSSEPKRDSSA--FPKKASQPPLSDFPKKPPQPELGDLTRTSSEPEVSVLPKRPRP 311
             +P  +  +R S+     + AS+   S           G   R +  P     P +P+P
Sbjct: 217 TTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGT--PRAPAHPSQPKP 274

Query: 312 AEFKALSKKPPQ---------PELGGLPRTSSEPEFNSLPRKLLQPERRGPPRKFSQPEP 362
              +AL  +PPQ         P LG L   SS P     P   LQ +   PP   + P  
Sbjct: 275 KGLQAL--RPPQVTPPRKDAAPALGPL---SSSPLATPSPSAALQSQ--APPTLPATPHS 327

Query: 363 SAVLKRHPQPEFFGDLPRKPPLPSSA-SESSLPAAVAGFSSRHPLSPGFGAAGTPRWRSG 421
           S++  +   P     LP  PP PS+  S  +LP+  A      P S    + G+P  ++ 
Sbjct: 328 SSLTCQLATP-----LPLAPPSPSAPPSLQTLPSPPAT-----PPSQATTSLGSPTLQA- 376

Query: 422 GLVHSGGARPGLRP--SHPPRRRP---LPPASSLGHPPAKPPLPPGPVDMQSFRRPSAAS 476
              HS    P L P  + PP+  P   LPP  +   PPA PPL   P+   S + P+A +
Sbjct: 377 --THSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPL--SPLATPSPQAPNALA 432

Query: 477 IDLRRTRSAAGLHFQDRQPEDIPVPDEIYELYDDVEPRDDSSPSPKGRDEAPSVQQAARR 536
           + L        L      P   PV                + PS      A    Q    
Sbjct: 433 VHL--------LQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPS 484

Query: 537 PPQDPALRKEKDPQPQQLPPM 557
           PP  P +     P PQ  PP+
Sbjct: 485 PPASPPMSPSATPPPQAPPPL 505



 Score = 67.4 bits (163), Expect = 4e-11
 Identities = 111/475 (23%), Positives = 151/475 (31%), Gaps = 98/475 (20%)

Query: 16  RSIKAKFQASQPEPSDLPKKPPKPEFGKLKKFSQP-ELSEHPKKAPLPEFGAVSLKPPPP 74
           +S+ +  + S  EPS   ++ P    G  +  S+    S  P  +P     +    P  P
Sbjct: 207 KSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAP 266

Query: 75  EVTDLPKKPP-----PPEVTDLPKKPPPPEVTDLPKKP---PPPEVTDLPKKPSKLELSD 126
                PK        PP+VT  P+K   P +  L   P   P P      + P  L  + 
Sbjct: 267 AHPSQPKPKGLQALRPPQVTP-PRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATP 325

Query: 127 LSKKFPQLGATPFPRKPLQPEVGEAPLKASLPEPGAPARKPLQPD-ELSHPARPPSEPKS 185
            S       ATP P  P  P     P   +LP P  PA  P Q    L  P    +    
Sbjct: 326 HSSSLTCQLATPLPLAPPSPSA--PPSLQTLPSP--PATPPSQATTSLGSPTLQATHSFL 381

Query: 186 GAFPRKLWQPEAGEATPRSPQPELSTFPKKPAQPEFNVYPKKPPQPQVGGLPKKSVPQPE 245
            + P         +A P    P L   P  PA P  +  P   P PQ        + Q  
Sbjct: 382 PSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLS--PLATPSPQAPNALAVHLLQAP 439

Query: 246 FSEAAQTPLWKPQS--SEPKRDSSAFPKKASQPPLSDFPKKPPQPELGDLTRTSSEPEVS 303
           FS     P+  P S  + P    SA P   + P L+                    P + 
Sbjct: 440 FSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLA-------------------APPLQ 480

Query: 304 VLPKRPRPAEFKALSKKPPQPELGGLPRTSSEPEFNSLPRKLLQPERRGPPRKFSQPEPS 363
           V P  P        +  PPQ                        P    PP + ++P P 
Sbjct: 481 VPPSPPASPPMSPSATPPPQAP----------------------PPLAAPPLQLAKPPPQ 518

Query: 364 AVLKRHPQPEFFGDLPRKPPLPSSASESSLPAAVAGFSSRHPLSPGFGAAGTPRWRSGGL 423
           A                 PP  ++    +LP+  A F  + P SP           S  L
Sbjct: 519 A-----------------PPALATPPLQALPSPPASFPGQAPFSP-----------SASL 550

Query: 424 VHSGGARPGLRPSHPPRRRPLPPASSLGHPPAKPPLPPGPVDMQSFRRPSAASID 478
             S  A P      PP+  P+  A  L  PP+    PP    +Q+ RRP     D
Sbjct: 551 PMSPLATP------PPQAPPVLAAPLLQVPPS----PPASPTLQAPRRPPTPGPD 595



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 113/454 (24%), Positives = 143/454 (31%), Gaps = 63/454 (13%)

Query: 135 GATPFPRKPLQPEVGEAP-LKASLPEPGAPARKPLQPDE------LSHPARPPSEPKSGA 187
           G TP    P       A   +  LP P AP+ +P  P E       S      +EP   A
Sbjct: 166 GPTPGTPSPAMARRSRAAGTEVGLPRP-APSARPRPPTEGPRKSVSSASEHSTTEPSPAA 224

Query: 188 FPRKLWQPEAGEATPRSPQPELSTFPKKPAQPEFNV--------YPKKPPQPQVGGLPKK 239
             R    P AG    R     LS+     + P  +          P  P QP+  GL   
Sbjct: 225 RRR----PSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQAL 280

Query: 240 SVPQPEFSEAAQTPLWKPQSSEPKRDSSAFPKKASQPPLSDFPKKPPQPELGDLTRTSSE 299
             PQ         P   P SS P    S      SQ P    P  P  P    LT   + 
Sbjct: 281 RPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAP----PTLPATPHSSSLTCQLAT 336

Query: 300 PEVSVLPKRPRPAEFKALSKKP---PQPELGGLPRTSSEPEFNSLPRKLLQPERRGPPRK 356
           P     P    P   + L   P   P      L   + +   + LP   L P    PP+ 
Sbjct: 337 PLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQA 396

Query: 357 FSQPEPSAV--LKRHPQPEFFGDLPRKPPLPSSASES-SLPAAVAGFSSRHPLSPGFGAA 413
              P   A+  L+  P P      P  PPL   A+ S   P A+A    + P SP     
Sbjct: 397 ---PPALALPPLQAPPSP------PASPPLSPLATPSPQAPNALAVHLLQAPFSP----- 442

Query: 414 GTPRWRSGGLVHSGGARPGLRPSH-PPRRRP----LPPASSLGHPPAKPPLPPGPVDMQS 468
             P         S  A P + PS  PP + P     PP      PPA PP+ P       
Sbjct: 443 --PPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQ 500

Query: 469 FRRPSAA-SIDLRRTRSAAGLHFQDRQPEDIPVPDEIYELYDDVEPRDDSSPSPKGRDEA 527
              P AA  + L +    A         + +P P           P      +P     +
Sbjct: 501 APPPLAAPPLQLAKPPPQAPPALATPPLQALPSP-----------PASFPGQAPFSPSAS 549

Query: 528 PSVQQAARRPPQDPALRKEKDPQPQQLPPMDPKL 561
             +   A  PPQ P +      Q    PP  P L
Sbjct: 550 LPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTL 583


>gi|160707881 formin 2 [Homo sapiens]
          Length = 1722

 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 142/503 (28%), Positives = 173/503 (34%), Gaps = 79/503 (15%)

Query: 9    MESHQDFRSIKAK-------FQASQPEPSDLPKKPPKPEFGKLKKFSQPELSEH----PK 57
            ++SHQ  +SI          + A Q +P   P      EF    + S     ++    P 
Sbjct: 798  LDSHQPTQSISQPPPPPSLLWSAGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPS 857

Query: 58   KAPLP------EFGAVSLKPPPPE------VTDLPK----KPPPPEVTD-LPKKPPPPEV 100
              PLP          + + PPPP       V  LP     +PPP + T+ LP  PPP   
Sbjct: 858  PPPLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPG 917

Query: 101  TDLPKKPPPPEVTDLPKKPSKLELSDLSKKFPQLGATPFPRKPLQPEVGEAPLKASLPEP 160
              +P  PP P    LP  P  L  + +    P  GA   P  PL P  G  PL   LP  
Sbjct: 918  AGIPPPPPLPGAGILPLPP--LPGAGIPPPPPLPGAAIPPPPPL-PGAG-IPLPPPLPGA 973

Query: 161  GAPARKPL------QPDELSHPARPPSEPKSGA-FPRKLWQPEAGEATPRSPQPELSTFP 213
            G P   PL       P  L     PP  P  GA  P     P  G   P  P    +  P
Sbjct: 974  GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPP--PPLPGAGIPPPPPLPGAGIP 1031

Query: 214  KKPAQPEFNVYPKKPPQPQVG-----GLPKKSVPQPEFSEAAQTPLWKPQSSEPKRDSSA 268
              P  P   + P  PP P  G      LP   +P P     A  P        P    + 
Sbjct: 1032 PPPPLPGAGI-PPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIP------PPPPLPGAG 1084

Query: 269  FPKKASQPPL--SDFPKKPPQPELGDLTRTSSEPEVSVLPKRPRPAEFKALSKKPPQPEL 326
             P     PPL  +  P  PP P +G +      P   + P  P P      +  PP P L
Sbjct: 1085 IP---PPPPLPGAGIPPPPPLPGVG-IPPPPPLPGAGIPPPPPLPG-----AGIPPPPPL 1135

Query: 327  GGLPRTSSEPEFNSLPRKLLQPERRGPPRKFSQPEPSAVLKRHPQPEFFG-DLPRKPPLP 385
             G    +  P    LPR  + P    P      P P       P P   G  +P  PPLP
Sbjct: 1136 PG----AGIPPPPPLPRVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLP 1191

Query: 386  SSASESSLPAAVAGFSSRHPLSPGFG--AAGTPRWRSGGLVHSGGARPGLRPSHPPRRRP 443
                    P   AG     PL PG G   A  P     G   +G   P L P   P   P
Sbjct: 1192 GVGIPPPPPLPGAGIPPPPPL-PGMGIPPAPAPPLPPPG---TGIPPPPLLPVSGPPLLP 1247

Query: 444  LPPASSLGHPPA----KPPLPPG 462
               +S+L  P       PPLP G
Sbjct: 1248 QVGSSTLPTPQVCGFLPPPLPSG 1270



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 54/208 (25%), Positives = 75/208 (36%), Gaps = 47/208 (22%)

Query: 276 PPLSDFPKKPPQP---ELGDLTRTSSEPEVSVLPKR-----PRPAEFKALSKKPPQPEL- 326
           PP+   P +PP P   E G  T+  SE  + V P+R           +++S+ PP P L 
Sbjct: 758 PPVDGLPGRPPCPPGAESGPQTKFCSEISLIVSPRRISVQLDSHQPTQSISQPPPPPSLL 817

Query: 327 --GGLPRTSSEPEFNSLPRKLLQPERRGPPRKFSQPEPSAVLKRHPQPEFFGDLPRKPPL 384
              G  +  S+P  +S+  +            F                   ++P  PPL
Sbjct: 818 WSAGQGQPGSQPP-HSISTEFQTSHEHSVSSAFKNS---------------CNIPSPPPL 861

Query: 385 PSSASESSLPAAVAGFSSRHPLSPGFGAAGTPRWRSGGLVHSGGARPGLRPSH--PPRRR 442
           P + S SS+P    G     P  P       P   S  +       P L+ +   PP   
Sbjct: 862 PCTESSSSMP----GLGMVPPPPPPLPGMTVPTLPSTAIPQP----PPLQGTEMLPP--- 910

Query: 443 PLPPASSLGHPPAKP-------PLPPGP 463
           P PP    G PP  P       PLPP P
Sbjct: 911 PPPPLPGAGIPPPPPLPGAGILPLPPLP 938



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 52/196 (26%), Positives = 70/196 (35%), Gaps = 29/196 (14%)

Query: 104 PKKPPPPEVTDLPKKPSKLELSDLSKKFPQLGATPFPRKPLQPEVGEAPLKASLPEPGAP 163
           P++PP P    + + PS       +K  P   A PF      PE G     A     GAP
Sbjct: 290 PQQPPSPGGLPVSEAPSLPAAQPAAKDSPSSTAFPF------PEAGPGEEAA-----GAP 338

Query: 164 ARKPLQPDELSHPARPPSEPKSGAFPRKLWQPEAGEATPRSPQPELSTFPKKPAQPEFNV 223
            R     DE          P+    P + W PE GE  P+     L   P++ AQ     
Sbjct: 339 VRGAGDTDEEGEEDAFEDAPRGS--PGEEWAPEVGEDAPQ----RLGEEPEEEAQ----- 387

Query: 224 YPKKPPQPQVGGLPKKSVPQPEFSEAAQTPLWKP--QSSEPKRDSSAFPKKASQPPLSDF 281
               P  P    LP    P P        PL  P    +  ++ SS     +  P  S  
Sbjct: 388 ---GPDAPAAASLP--GSPAPSQRCFKPYPLITPCYIKTTTRQLSSPNHSPSQSPNQSPR 442

Query: 282 PKKPPQPELGDLTRTS 297
            K+ P+P L   +RT+
Sbjct: 443 IKRRPEPSLSRGSRTA 458


>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
          Length = 1270

 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 127/566 (22%), Positives = 193/566 (34%), Gaps = 94/566 (16%)

Query: 28  EPSDLPKKPPKPEFGKLKKFSQPELSEHPKKAPLPEFGAVSL-KPPPPEVTDLPKKPPPP 86
           EP+    K P P   K    S P   + P  AP     A +  K P P  T  P    P 
Sbjct: 223 EPASTTPKEPTPTTIK----SAPTTPKEP--APTTTKSAPTTPKEPAPTTTKEPAPTTPK 276

Query: 87  EVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPSKLELSDLSKKFPQLGATPFPRKPLQP 146
           E      K P P  T      P       PKKP+     + +   P+      P++P   
Sbjct: 277 EPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPT 336

Query: 147 EVGEAPLKASLPEPGAPAR------------KPLQPDELSHPARPPSEPKSGA------F 188
               AP     P P AP +             P +P   +     P+ PK  A       
Sbjct: 337 TKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSA 396

Query: 189 PRKLWQP-----EAGEATPRSPQPELS-----TFPKKPAQPEFNVYPKKP----PQPQVG 234
           P    +P     ++   TP+ P P  +     T PK+PA       PKKP    P+    
Sbjct: 397 PTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAP----TTPKKPAPTTPKEPAP 452

Query: 235 GLPKKSVPQPEFSEAAQTPLWKPQSSEPKRDSSAFPKKAS----QPPLSDFPKKPPQPEL 290
             PK+  P      A  TP  +P  + PK  +   PKK +    +      P+KP     
Sbjct: 453 TTPKEPAPTTTKKPAPTTPK-EPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTP 511

Query: 291 GDLTRTSSEPEVSVLPKRPRPAEFKALSKKPPQPELGGLPR----TSSEPEFNSLPRKLL 346
            +L  T+ E      P+ P P   KA +   P+      P+    T+ +    + P++  
Sbjct: 512 EELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETA 571

Query: 347 QPERRG-PPRKFSQPEPSAVLKRHPQPEFFGDLPRKPPLPSSASESSLPAAVAGFSSRHP 405
               +G  P    +P P+   K  P P+       K P  S+  +   P    G +   P
Sbjct: 572 PTTPKGTAPTTLKEPAPTTPKK--PAPKELAPTTTKEP-TSTTCDKPAPTTPKGTAPTTP 628

Query: 406 LSPGFGAAGTPRWRSGGLVHSGGARPGLR-PSHPPRRRPLP----------PASSLGHPP 454
             P   A  TP+         G A   L+ P+    ++P P          P S+    P
Sbjct: 629 KEP---APTTPK-EPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKP 684

Query: 455 A------------KPPLPPGPVDMQSFRRPSAASIDLRRTRSAAGLHFQDRQPEDIPVPD 502
           A            K P P  P      ++P+  + +     ++     +   P     P 
Sbjct: 685 APTTPKETAPTTPKEPAPTTP------KKPAPTTPETPPPTTS-----EVSTPTTTKEPT 733

Query: 503 EIYELYDDVEPRDDSSPSPKGRDEAP 528
            I++  D+  P   + P+PK  + +P
Sbjct: 734 TIHKSPDESTPELSAEPTPKALENSP 759



 Score = 84.3 bits (207), Expect = 3e-16
 Identities = 141/637 (22%), Positives = 208/637 (32%), Gaps = 111/637 (17%)

Query: 28  EPSDLPKKPPKPEFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPPPEVTDLPKKPPPPE 87
           EP+    K P P   K    +  E +    K P P          P E      K P P 
Sbjct: 316 EPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPT 375

Query: 88  VTD-----LPKKPPPPEVTDLPK--KPPPPEVTD----LPKKPSKLELSDLSKKFPQLGA 136
            T       PK+P P      P   K P P  T      PK+PS     + +   P+  A
Sbjct: 376 TTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPA 435

Query: 137 TPFPRKPLQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARPPSEPKSGA--FPRKLWQ 194
              P+KP  P   + P   +  EP     K   P     PA  P+ PK  A   P+KL  
Sbjct: 436 PTTPKKPA-PTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPA--PTTPKETAPTTPKKLTP 492

Query: 195 PEAGEATPRSPQPELSTFPKK--PAQPE--FNVYPKKP----PQPQVGGLPKKSVPQPEF 246
               +  P +P+    T P++  P  PE      P++P    P+      PK+  P    
Sbjct: 493 TTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPK 552

Query: 247 SEAAQTPLWKPQSSEPKRDSSAFPKKAS----QPPLSDFPKKPPQPELGDLTR------- 295
             A  TP  +P  + PK  +   PK  +    + P    PKKP   EL   T        
Sbjct: 553 EPAPTTPK-EPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTT 611

Query: 296 ------TSSEPEVSVLPKRPRPAEFKALSKKPPQPELGGLPRTSSEPEFNS----LPRKL 345
                 T+ +      PK P P   K  +   P+   G  P T  EP   +     P++L
Sbjct: 612 CDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPK---GTAPTTLKEPAPTTPKKPAPKEL 668

Query: 346 LQPERRGP-------PRKFSQPEPSAVLKRHPQPEFFGDLPRKPPL------PSSASESS 392
                +GP       P   +  E +    + P P      P+KP        P + SE S
Sbjct: 669 APTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPT----TPKKPAPTTPETPPPTTSEVS 724

Query: 393 LPAAVAGFSSRHPL----SPGFGAAGTPRWRSGGLVHSGGARPGLRPSHPPRRRPLPPAS 448
            P      ++ H      +P   A  TP+      + +    PG+  +  P        +
Sbjct: 725 TPTTTKEPTTIHKSPDESTPELSAEPTPK-----ALENSPKEPGVPTTKTPAATKPEMTT 779

Query: 449 SLGH----------PPAKPPLPPGPVDMQSFRRPSAASIDLRRTRSAAGLHFQDRQPEDI 498
           +             P      P    +  +    +  S     T        QD  P  I
Sbjct: 780 TAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKI 839

Query: 499 PV-------------------------PDEIYELYDDVEPRDDSSPSPKGRDEAPSVQQA 533
                                      P+E  +  D       ++P P+   +AP    +
Sbjct: 840 TTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTS 899

Query: 534 ARRPPQDPALRKEK-DPQPQQLPPMDPKLLKQLRKAE 569
            ++P   P +RK K  P P+++    P+L    R AE
Sbjct: 900 TKKPKTMPRVRKPKTTPTPRKMTSTMPELNPTSRIAE 936



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 125/561 (22%), Positives = 201/561 (35%), Gaps = 101/561 (18%)

Query: 40  EFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPPPEVTDLPKKPPPPE----VTDLPKKP 95
           E   ++K S  +L+   K    P   A +    P   T  PK+P P       +  PK+P
Sbjct: 175 ETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTT--PKEPTPTTPKEPASTTPKEP 232

Query: 96  PPPEVTDLP---KKPPPPEVTDLPKKPSKLELSDLSKKFPQLGATPFP---RKPLQPEVG 149
            P  +   P   K+P P      P  P +   +   +  P     P P   ++P      
Sbjct: 233 TPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTK 292

Query: 150 EAPLKASLPEPGAPAR----KPLQPDELSHPARPPSEPKSGAFPRKLWQPEAGEATPRSP 205
            AP     P P  P +     P +P   +     P+ PK  A       P   E  P +P
Sbjct: 293 SAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPA-------PTTKEPAPTTP 345

Query: 206 QPELSTFPKKPAQPEFNVYPKKP-------PQPQVGGLPKKSVPQ---PEFSEAAQTPLW 255
           +    T PKKPA       PK+P       P P     P  + P+   P  +++A T   
Sbjct: 346 KEPAPTAPKKPAP----TTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTK 401

Query: 256 KPQSSEPKRDSSAFPKKAS----QPPLSDFPKKPPQPELGDLTRTSSEPEVSVLPKRPRP 311
           +P  +  K  +   PK+ S    + P    PK+P          T+ +      PK P P
Sbjct: 402 EPAPTTTK-SAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAP 460

Query: 312 AEFKALSKKPPQPELGGLPRTSSEPEFNSLPRKL--LQPERRGPPRKFSQPEPSAVLKRH 369
              K  +   P+      P+ ++     + P+KL    PE+  P     +P P+      
Sbjct: 461 TTTKKPAPTTPKEPAPTTPKETAP----TTPKKLTPTTPEKLAPTTP-EKPAPTT----- 510

Query: 370 PQPEFFGDLPRKPPLPSSASE--SSLPAAVAGFSSRH--PLSPGFGAAGTPRWRSGGLVH 425
             PE       + P P++  E   + P A A  + +   P +P   A  TP+  +     
Sbjct: 511 --PEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPA----- 563

Query: 426 SGGARPGLRPSHPPRRRPLPP----ASSLGHPPAKPPLPPGPVDM--QSFRRPSAASIDL 479
                    P+ P    P  P     ++L  P    P  P P ++   + + P++ + D 
Sbjct: 564 ---------PTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDK 614

Query: 480 RRTRSAAGLHFQDRQPEDIPVPDEIYELYDDVEPRDDSSPSPKGRDEAPSVQQAARRPPQ 539
               +  G       P++ P P           P++ +  +PKG   AP+         +
Sbjct: 615 PAPTTPKGT--APTTPKE-PAP---------TTPKEPAPTTPKG--TAPTTL-------K 653

Query: 540 DPALRKEKDPQPQQLPPMDPK 560
           +PA    K P P++L P   K
Sbjct: 654 EPAPTTPKKPAPKELAPTTTK 674



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 77/359 (21%), Positives = 124/359 (34%), Gaps = 34/359 (9%)

Query: 26  QPEPSDLPKKPPKPEFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPPPEVTDLPKKPPP 85
           +P P+   +  P    G      +      PKK    E    + K P     D P    P
Sbjct: 561 EPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTP 620

Query: 86  PEVTDLPKKPPPPEVTDLPKKPPP--PEVT----------DLPKKPSKLELSDLSKKFPQ 133
                   K P P     PK+P P  P+ T            PKKP+  EL+  + K P 
Sbjct: 621 KGTAPTTPKEPAPTT---PKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPT 677

Query: 134 LGATPFPRKPLQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARPPSEPKSGAFPRKLW 193
              +  P      E   AP     P P  P +KP      + P  PP      + P    
Sbjct: 678 STTSDKPAPTTPKET--APTTPKEPAPTTP-KKPAP----TTPETPPPTTSEVSTPTTTK 730

Query: 194 QPEAGEATPRSPQPELSTFPKKPAQPEFNVYPKKPPQPQVGGLPKKSVPQPEFSEAAQTP 253
           +P     +P    PELS      A+P        P +P V      +  +PE +  A+  
Sbjct: 731 EPTTIHKSPDESTPELS------AEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDK 784

Query: 254 LWKPQSSEPKRDSSAFPKKASQPPLSDFPKKPPQPELGDLTRTSSEPEVSVLPKRPRPAE 313
             +         ++A PK   +   +   +K  + +   +T T+++   S   +   P +
Sbjct: 785 TTERDLRTTPETTTAAPKMTKETATT--TEKTTESK---ITATTTQ-VTSTTTQDTTPFK 838

Query: 314 FKALSKKPPQPELGGLPRTSSEPEFNSLPRKLLQPERRGPPRKFSQPEPSAVLKRHPQP 372
              L      P++    +T +  E  + P +  +P+ R    K + P+P    K   +P
Sbjct: 839 ITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKP 897



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 76/341 (22%), Positives = 123/341 (36%), Gaps = 48/341 (14%)

Query: 26  QPEPSDLPKKP-PKPEFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPPPEVTDLPKKPP 84
           +P P+  PK+P P    G      +      PKK    E    + K P    +D P    
Sbjct: 630 EPAPTT-PKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTT 688

Query: 85  PPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPSKLELSDLSKKFPQLGATPFPRKP- 143
           P E      K P P     PKKP P      P   S++     +K+   +  +P    P 
Sbjct: 689 PKETAPTTPKEPAPTT---PKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPE 745

Query: 144 LQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARPPSEPKSGAFPRKLWQPEAGEATPR 203
           L  E     L+ S  EPG P  K                                  TP 
Sbjct: 746 LSAEPTPKALENSPKEPGVPTTK----------------------------------TPA 771

Query: 204 SPQPELSTFPK-KPAQPEFNVYPK-KPPQPQVGGLPKKSVPQPEFSEAAQTPLWKPQSSE 261
           + +PE++T  K K  + +    P+     P++    + +    + +E+  T      +S 
Sbjct: 772 ATKPEMTTTAKDKTTERDLRTTPETTTAAPKM--TKETATTTEKTTESKITATTTQVTST 829

Query: 262 PKRDSSAFPKKASQPPLSDFPKKPPQPELGDLTRTSSEPEVSVLPKRPRPAEFKALSKKP 321
             +D++ F K  +    +  PK     +    T   ++PE +  PK  R    KA + KP
Sbjct: 830 TTQDTTPF-KITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPK-DRATNSKATTPKP 887

Query: 322 PQPELGGLPRTSSEPEFNSLPRKLLQPERRGPPRKFSQPEP 362
            +P       TS++    ++PR + +P+    PRK +   P
Sbjct: 888 QKPTKAPKKPTSTKKP-KTMPR-VRKPKTTPTPRKMTSTMP 926


>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
          Length = 1311

 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 127/566 (22%), Positives = 193/566 (34%), Gaps = 94/566 (16%)

Query: 28  EPSDLPKKPPKPEFGKLKKFSQPELSEHPKKAPLPEFGAVSL-KPPPPEVTDLPKKPPPP 86
           EP+    K P P   K    S P   + P  AP     A +  K P P  T  P    P 
Sbjct: 264 EPASTTPKEPTPTTIK----SAPTTPKEP--APTTTKSAPTTPKEPAPTTTKEPAPTTPK 317

Query: 87  EVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPSKLELSDLSKKFPQLGATPFPRKPLQP 146
           E      K P P  T      P       PKKP+     + +   P+      P++P   
Sbjct: 318 EPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPT 377

Query: 147 EVGEAPLKASLPEPGAPAR------------KPLQPDELSHPARPPSEPKSGA------F 188
               AP     P P AP +             P +P   +     P+ PK  A       
Sbjct: 378 TKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSA 437

Query: 189 PRKLWQP-----EAGEATPRSPQPELS-----TFPKKPAQPEFNVYPKKP----PQPQVG 234
           P    +P     ++   TP+ P P  +     T PK+PA       PKKP    P+    
Sbjct: 438 PTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAP----TTPKKPAPTTPKEPAP 493

Query: 235 GLPKKSVPQPEFSEAAQTPLWKPQSSEPKRDSSAFPKKAS----QPPLSDFPKKPPQPEL 290
             PK+  P      A  TP  +P  + PK  +   PKK +    +      P+KP     
Sbjct: 494 TTPKEPAPTTTKKPAPTTPK-EPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTP 552

Query: 291 GDLTRTSSEPEVSVLPKRPRPAEFKALSKKPPQPELGGLPR----TSSEPEFNSLPRKLL 346
            +L  T+ E      P+ P P   KA +   P+      P+    T+ +    + P++  
Sbjct: 553 EELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETA 612

Query: 347 QPERRG-PPRKFSQPEPSAVLKRHPQPEFFGDLPRKPPLPSSASESSLPAAVAGFSSRHP 405
               +G  P    +P P+   K  P P+       K P  S+  +   P    G +   P
Sbjct: 613 PTTPKGTAPTTLKEPAPTTPKK--PAPKELAPTTTKEP-TSTTCDKPAPTTPKGTAPTTP 669

Query: 406 LSPGFGAAGTPRWRSGGLVHSGGARPGLR-PSHPPRRRPLP----------PASSLGHPP 454
             P   A  TP+         G A   L+ P+    ++P P          P S+    P
Sbjct: 670 KEP---APTTPK-EPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKP 725

Query: 455 A------------KPPLPPGPVDMQSFRRPSAASIDLRRTRSAAGLHFQDRQPEDIPVPD 502
           A            K P P  P      ++P+  + +     ++     +   P     P 
Sbjct: 726 APTTPKETAPTTPKEPAPTTP------KKPAPTTPETPPPTTS-----EVSTPTTTKEPT 774

Query: 503 EIYELYDDVEPRDDSSPSPKGRDEAP 528
            I++  D+  P   + P+PK  + +P
Sbjct: 775 TIHKSPDESTPELSAEPTPKALENSP 800



 Score = 84.3 bits (207), Expect = 3e-16
 Identities = 141/637 (22%), Positives = 208/637 (32%), Gaps = 111/637 (17%)

Query: 28  EPSDLPKKPPKPEFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPPPEVTDLPKKPPPPE 87
           EP+    K P P   K    +  E +    K P P          P E      K P P 
Sbjct: 357 EPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPT 416

Query: 88  VTD-----LPKKPPPPEVTDLPK--KPPPPEVTD----LPKKPSKLELSDLSKKFPQLGA 136
            T       PK+P P      P   K P P  T      PK+PS     + +   P+  A
Sbjct: 417 TTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPA 476

Query: 137 TPFPRKPLQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARPPSEPKSGA--FPRKLWQ 194
              P+KP  P   + P   +  EP     K   P     PA  P+ PK  A   P+KL  
Sbjct: 477 PTTPKKPA-PTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPA--PTTPKETAPTTPKKLTP 533

Query: 195 PEAGEATPRSPQPELSTFPKK--PAQPE--FNVYPKKP----PQPQVGGLPKKSVPQPEF 246
               +  P +P+    T P++  P  PE      P++P    P+      PK+  P    
Sbjct: 534 TTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPK 593

Query: 247 SEAAQTPLWKPQSSEPKRDSSAFPKKAS----QPPLSDFPKKPPQPELGDLTR------- 295
             A  TP  +P  + PK  +   PK  +    + P    PKKP   EL   T        
Sbjct: 594 EPAPTTPK-EPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTT 652

Query: 296 ------TSSEPEVSVLPKRPRPAEFKALSKKPPQPELGGLPRTSSEPEFNS----LPRKL 345
                 T+ +      PK P P   K  +   P+   G  P T  EP   +     P++L
Sbjct: 653 CDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPK---GTAPTTLKEPAPTTPKKPAPKEL 709

Query: 346 LQPERRGP-------PRKFSQPEPSAVLKRHPQPEFFGDLPRKPPL------PSSASESS 392
                +GP       P   +  E +    + P P      P+KP        P + SE S
Sbjct: 710 APTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPT----TPKKPAPTTPETPPPTTSEVS 765

Query: 393 LPAAVAGFSSRHPL----SPGFGAAGTPRWRSGGLVHSGGARPGLRPSHPPRRRPLPPAS 448
            P      ++ H      +P   A  TP+      + +    PG+  +  P        +
Sbjct: 766 TPTTTKEPTTIHKSPDESTPELSAEPTPK-----ALENSPKEPGVPTTKTPAATKPEMTT 820

Query: 449 SLGH----------PPAKPPLPPGPVDMQSFRRPSAASIDLRRTRSAAGLHFQDRQPEDI 498
           +             P      P    +  +    +  S     T        QD  P  I
Sbjct: 821 TAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKI 880

Query: 499 PV-------------------------PDEIYELYDDVEPRDDSSPSPKGRDEAPSVQQA 533
                                      P+E  +  D       ++P P+   +AP    +
Sbjct: 881 TTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTS 940

Query: 534 ARRPPQDPALRKEK-DPQPQQLPPMDPKLLKQLRKAE 569
            ++P   P +RK K  P P+++    P+L    R AE
Sbjct: 941 TKKPKTMPRVRKPKTTPTPRKMTSTMPELNPTSRIAE 977



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 125/561 (22%), Positives = 201/561 (35%), Gaps = 101/561 (18%)

Query: 40  EFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPPPEVTDLPKKPPPPE----VTDLPKKP 95
           E   ++K S  +L+   K    P   A +    P   T  PK+P P       +  PK+P
Sbjct: 216 ETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTT--PKEPTPTTPKEPASTTPKEP 273

Query: 96  PPPEVTDLP---KKPPPPEVTDLPKKPSKLELSDLSKKFPQLGATPFP---RKPLQPEVG 149
            P  +   P   K+P P      P  P +   +   +  P     P P   ++P      
Sbjct: 274 TPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTK 333

Query: 150 EAPLKASLPEPGAPAR----KPLQPDELSHPARPPSEPKSGAFPRKLWQPEAGEATPRSP 205
            AP     P P  P +     P +P   +     P+ PK  A       P   E  P +P
Sbjct: 334 SAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPA-------PTTKEPAPTTP 386

Query: 206 QPELSTFPKKPAQPEFNVYPKKP-------PQPQVGGLPKKSVPQ---PEFSEAAQTPLW 255
           +    T PKKPA       PK+P       P P     P  + P+   P  +++A T   
Sbjct: 387 KEPAPTAPKKPAP----TTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTK 442

Query: 256 KPQSSEPKRDSSAFPKKAS----QPPLSDFPKKPPQPELGDLTRTSSEPEVSVLPKRPRP 311
           +P  +  K  +   PK+ S    + P    PK+P          T+ +      PK P P
Sbjct: 443 EPAPTTTK-SAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAP 501

Query: 312 AEFKALSKKPPQPELGGLPRTSSEPEFNSLPRKL--LQPERRGPPRKFSQPEPSAVLKRH 369
              K  +   P+      P+ ++     + P+KL    PE+  P     +P P+      
Sbjct: 502 TTTKKPAPTTPKEPAPTTPKETAP----TTPKKLTPTTPEKLAPTTP-EKPAPTT----- 551

Query: 370 PQPEFFGDLPRKPPLPSSASE--SSLPAAVAGFSSRH--PLSPGFGAAGTPRWRSGGLVH 425
             PE       + P P++  E   + P A A  + +   P +P   A  TP+  +     
Sbjct: 552 --PEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPA----- 604

Query: 426 SGGARPGLRPSHPPRRRPLPP----ASSLGHPPAKPPLPPGPVDM--QSFRRPSAASIDL 479
                    P+ P    P  P     ++L  P    P  P P ++   + + P++ + D 
Sbjct: 605 ---------PTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDK 655

Query: 480 RRTRSAAGLHFQDRQPEDIPVPDEIYELYDDVEPRDDSSPSPKGRDEAPSVQQAARRPPQ 539
               +  G       P++ P P           P++ +  +PKG   AP+         +
Sbjct: 656 PAPTTPKGT--APTTPKE-PAP---------TTPKEPAPTTPKG--TAPTTL-------K 694

Query: 540 DPALRKEKDPQPQQLPPMDPK 560
           +PA    K P P++L P   K
Sbjct: 695 EPAPTTPKKPAPKELAPTTTK 715



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 77/359 (21%), Positives = 124/359 (34%), Gaps = 34/359 (9%)

Query: 26  QPEPSDLPKKPPKPEFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPPPEVTDLPKKPPP 85
           +P P+   +  P    G      +      PKK    E    + K P     D P    P
Sbjct: 602 EPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTP 661

Query: 86  PEVTDLPKKPPPPEVTDLPKKPPP--PEVT----------DLPKKPSKLELSDLSKKFPQ 133
                   K P P     PK+P P  P+ T            PKKP+  EL+  + K P 
Sbjct: 662 KGTAPTTPKEPAPTT---PKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPT 718

Query: 134 LGATPFPRKPLQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARPPSEPKSGAFPRKLW 193
              +  P      E   AP     P P  P +KP      + P  PP      + P    
Sbjct: 719 STTSDKPAPTTPKET--APTTPKEPAPTTP-KKPAP----TTPETPPPTTSEVSTPTTTK 771

Query: 194 QPEAGEATPRSPQPELSTFPKKPAQPEFNVYPKKPPQPQVGGLPKKSVPQPEFSEAAQTP 253
           +P     +P    PELS      A+P        P +P V      +  +PE +  A+  
Sbjct: 772 EPTTIHKSPDESTPELS------AEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDK 825

Query: 254 LWKPQSSEPKRDSSAFPKKASQPPLSDFPKKPPQPELGDLTRTSSEPEVSVLPKRPRPAE 313
             +         ++A PK   +   +   +K  + +   +T T+++   S   +   P +
Sbjct: 826 TTERDLRTTPETTTAAPKMTKETATT--TEKTTESK---ITATTTQ-VTSTTTQDTTPFK 879

Query: 314 FKALSKKPPQPELGGLPRTSSEPEFNSLPRKLLQPERRGPPRKFSQPEPSAVLKRHPQP 372
              L      P++    +T +  E  + P +  +P+ R    K + P+P    K   +P
Sbjct: 880 ITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKP 938



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 76/341 (22%), Positives = 123/341 (36%), Gaps = 48/341 (14%)

Query: 26  QPEPSDLPKKP-PKPEFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPPPEVTDLPKKPP 84
           +P P+  PK+P P    G      +      PKK    E    + K P    +D P    
Sbjct: 671 EPAPTT-PKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTT 729

Query: 85  PPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPSKLELSDLSKKFPQLGATPFPRKP- 143
           P E      K P P     PKKP P      P   S++     +K+   +  +P    P 
Sbjct: 730 PKETAPTTPKEPAPTT---PKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPE 786

Query: 144 LQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARPPSEPKSGAFPRKLWQPEAGEATPR 203
           L  E     L+ S  EPG P  K                                  TP 
Sbjct: 787 LSAEPTPKALENSPKEPGVPTTK----------------------------------TPA 812

Query: 204 SPQPELSTFPK-KPAQPEFNVYPK-KPPQPQVGGLPKKSVPQPEFSEAAQTPLWKPQSSE 261
           + +PE++T  K K  + +    P+     P++    + +    + +E+  T      +S 
Sbjct: 813 ATKPEMTTTAKDKTTERDLRTTPETTTAAPKM--TKETATTTEKTTESKITATTTQVTST 870

Query: 262 PKRDSSAFPKKASQPPLSDFPKKPPQPELGDLTRTSSEPEVSVLPKRPRPAEFKALSKKP 321
             +D++ F K  +    +  PK     +    T   ++PE +  PK  R    KA + KP
Sbjct: 871 TTQDTTPF-KITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPK-DRATNSKATTPKP 928

Query: 322 PQPELGGLPRTSSEPEFNSLPRKLLQPERRGPPRKFSQPEP 362
            +P       TS++    ++PR + +P+    PRK +   P
Sbjct: 929 QKPTKAPKKPTSTKKP-KTMPR-VRKPKTTPTPRKMTSTMP 967


>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
          Length = 1363

 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 127/566 (22%), Positives = 193/566 (34%), Gaps = 94/566 (16%)

Query: 28  EPSDLPKKPPKPEFGKLKKFSQPELSEHPKKAPLPEFGAVSL-KPPPPEVTDLPKKPPPP 86
           EP+    K P P   K    S P   + P  AP     A +  K P P  T  P    P 
Sbjct: 316 EPASTTPKEPTPTTIK----SAPTTPKEP--APTTTKSAPTTPKEPAPTTTKEPAPTTPK 369

Query: 87  EVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPSKLELSDLSKKFPQLGATPFPRKPLQP 146
           E      K P P  T      P       PKKP+     + +   P+      P++P   
Sbjct: 370 EPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPT 429

Query: 147 EVGEAPLKASLPEPGAPAR------------KPLQPDELSHPARPPSEPKSGA------F 188
               AP     P P AP +             P +P   +     P+ PK  A       
Sbjct: 430 TKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSA 489

Query: 189 PRKLWQP-----EAGEATPRSPQPELS-----TFPKKPAQPEFNVYPKKP----PQPQVG 234
           P    +P     ++   TP+ P P  +     T PK+PA       PKKP    P+    
Sbjct: 490 PTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAP----TTPKKPAPTTPKEPAP 545

Query: 235 GLPKKSVPQPEFSEAAQTPLWKPQSSEPKRDSSAFPKKAS----QPPLSDFPKKPPQPEL 290
             PK+  P      A  TP  +P  + PK  +   PKK +    +      P+KP     
Sbjct: 546 TTPKEPAPTTTKKPAPTTPK-EPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTP 604

Query: 291 GDLTRTSSEPEVSVLPKRPRPAEFKALSKKPPQPELGGLPR----TSSEPEFNSLPRKLL 346
            +L  T+ E      P+ P P   KA +   P+      P+    T+ +    + P++  
Sbjct: 605 EELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETA 664

Query: 347 QPERRG-PPRKFSQPEPSAVLKRHPQPEFFGDLPRKPPLPSSASESSLPAAVAGFSSRHP 405
               +G  P    +P P+   K  P P+       K P  S+  +   P    G +   P
Sbjct: 665 PTTPKGTAPTTLKEPAPTTPKK--PAPKELAPTTTKEP-TSTTCDKPAPTTPKGTAPTTP 721

Query: 406 LSPGFGAAGTPRWRSGGLVHSGGARPGLR-PSHPPRRRPLP----------PASSLGHPP 454
             P   A  TP+         G A   L+ P+    ++P P          P S+    P
Sbjct: 722 KEP---APTTPK-EPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKP 777

Query: 455 A------------KPPLPPGPVDMQSFRRPSAASIDLRRTRSAAGLHFQDRQPEDIPVPD 502
           A            K P P  P      ++P+  + +     ++     +   P     P 
Sbjct: 778 APTTPKETAPTTPKEPAPTTP------KKPAPTTPETPPPTTS-----EVSTPTTTKEPT 826

Query: 503 EIYELYDDVEPRDDSSPSPKGRDEAP 528
            I++  D+  P   + P+PK  + +P
Sbjct: 827 TIHKSPDESTPELSAEPTPKALENSP 852



 Score = 84.3 bits (207), Expect = 3e-16
 Identities = 141/637 (22%), Positives = 208/637 (32%), Gaps = 111/637 (17%)

Query: 28   EPSDLPKKPPKPEFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPPPEVTDLPKKPPPPE 87
            EP+    K P P   K    +  E +    K P P          P E      K P P 
Sbjct: 409  EPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPT 468

Query: 88   VTD-----LPKKPPPPEVTDLPK--KPPPPEVTD----LPKKPSKLELSDLSKKFPQLGA 136
             T       PK+P P      P   K P P  T      PK+PS     + +   P+  A
Sbjct: 469  TTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPA 528

Query: 137  TPFPRKPLQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARPPSEPKSGA--FPRKLWQ 194
               P+KP  P   + P   +  EP     K   P     PA  P+ PK  A   P+KL  
Sbjct: 529  PTTPKKPA-PTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPA--PTTPKETAPTTPKKLTP 585

Query: 195  PEAGEATPRSPQPELSTFPKK--PAQPE--FNVYPKKP----PQPQVGGLPKKSVPQPEF 246
                +  P +P+    T P++  P  PE      P++P    P+      PK+  P    
Sbjct: 586  TTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPK 645

Query: 247  SEAAQTPLWKPQSSEPKRDSSAFPKKAS----QPPLSDFPKKPPQPELGDLTR------- 295
              A  TP  +P  + PK  +   PK  +    + P    PKKP   EL   T        
Sbjct: 646  EPAPTTPK-EPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTT 704

Query: 296  ------TSSEPEVSVLPKRPRPAEFKALSKKPPQPELGGLPRTSSEPEFNS----LPRKL 345
                  T+ +      PK P P   K  +   P+   G  P T  EP   +     P++L
Sbjct: 705  CDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPK---GTAPTTLKEPAPTTPKKPAPKEL 761

Query: 346  LQPERRGP-------PRKFSQPEPSAVLKRHPQPEFFGDLPRKPPL------PSSASESS 392
                 +GP       P   +  E +    + P P      P+KP        P + SE S
Sbjct: 762  APTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPT----TPKKPAPTTPETPPPTTSEVS 817

Query: 393  LPAAVAGFSSRHPL----SPGFGAAGTPRWRSGGLVHSGGARPGLRPSHPPRRRPLPPAS 448
             P      ++ H      +P   A  TP+      + +    PG+  +  P        +
Sbjct: 818  TPTTTKEPTTIHKSPDESTPELSAEPTPK-----ALENSPKEPGVPTTKTPAATKPEMTT 872

Query: 449  SLGH----------PPAKPPLPPGPVDMQSFRRPSAASIDLRRTRSAAGLHFQDRQPEDI 498
            +             P      P    +  +    +  S     T        QD  P  I
Sbjct: 873  TAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKI 932

Query: 499  PV-------------------------PDEIYELYDDVEPRDDSSPSPKGRDEAPSVQQA 533
                                       P+E  +  D       ++P P+   +AP    +
Sbjct: 933  TTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTS 992

Query: 534  ARRPPQDPALRKEK-DPQPQQLPPMDPKLLKQLRKAE 569
             ++P   P +RK K  P P+++    P+L    R AE
Sbjct: 993  TKKPKTMPRVRKPKTTPTPRKMTSTMPELNPTSRIAE 1029



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 125/561 (22%), Positives = 201/561 (35%), Gaps = 101/561 (18%)

Query: 40  EFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPPPEVTDLPKKPPPPE----VTDLPKKP 95
           E   ++K S  +L+   K    P   A +    P   T  PK+P P       +  PK+P
Sbjct: 268 ETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTT--PKEPTPTTPKEPASTTPKEP 325

Query: 96  PPPEVTDLP---KKPPPPEVTDLPKKPSKLELSDLSKKFPQLGATPFP---RKPLQPEVG 149
            P  +   P   K+P P      P  P +   +   +  P     P P   ++P      
Sbjct: 326 TPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTK 385

Query: 150 EAPLKASLPEPGAPAR----KPLQPDELSHPARPPSEPKSGAFPRKLWQPEAGEATPRSP 205
            AP     P P  P +     P +P   +     P+ PK  A       P   E  P +P
Sbjct: 386 SAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPA-------PTTKEPAPTTP 438

Query: 206 QPELSTFPKKPAQPEFNVYPKKP-------PQPQVGGLPKKSVPQ---PEFSEAAQTPLW 255
           +    T PKKPA       PK+P       P P     P  + P+   P  +++A T   
Sbjct: 439 KEPAPTAPKKPAP----TTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTK 494

Query: 256 KPQSSEPKRDSSAFPKKAS----QPPLSDFPKKPPQPELGDLTRTSSEPEVSVLPKRPRP 311
           +P  +  K  +   PK+ S    + P    PK+P          T+ +      PK P P
Sbjct: 495 EPAPTTTK-SAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAP 553

Query: 312 AEFKALSKKPPQPELGGLPRTSSEPEFNSLPRKL--LQPERRGPPRKFSQPEPSAVLKRH 369
              K  +   P+      P+ ++     + P+KL    PE+  P     +P P+      
Sbjct: 554 TTTKKPAPTTPKEPAPTTPKETAP----TTPKKLTPTTPEKLAPTTP-EKPAPTT----- 603

Query: 370 PQPEFFGDLPRKPPLPSSASE--SSLPAAVAGFSSRH--PLSPGFGAAGTPRWRSGGLVH 425
             PE       + P P++  E   + P A A  + +   P +P   A  TP+  +     
Sbjct: 604 --PEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPA----- 656

Query: 426 SGGARPGLRPSHPPRRRPLPP----ASSLGHPPAKPPLPPGPVDM--QSFRRPSAASIDL 479
                    P+ P    P  P     ++L  P    P  P P ++   + + P++ + D 
Sbjct: 657 ---------PTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDK 707

Query: 480 RRTRSAAGLHFQDRQPEDIPVPDEIYELYDDVEPRDDSSPSPKGRDEAPSVQQAARRPPQ 539
               +  G       P++ P P           P++ +  +PKG   AP+         +
Sbjct: 708 PAPTTPKGT--APTTPKE-PAP---------TTPKEPAPTTPKG--TAPTTL-------K 746

Query: 540 DPALRKEKDPQPQQLPPMDPK 560
           +PA    K P P++L P   K
Sbjct: 747 EPAPTTPKKPAPKELAPTTTK 767



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 77/359 (21%), Positives = 124/359 (34%), Gaps = 34/359 (9%)

Query: 26  QPEPSDLPKKPPKPEFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPPPEVTDLPKKPPP 85
           +P P+   +  P    G      +      PKK    E    + K P     D P    P
Sbjct: 654 EPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTP 713

Query: 86  PEVTDLPKKPPPPEVTDLPKKPPP--PEVT----------DLPKKPSKLELSDLSKKFPQ 133
                   K P P     PK+P P  P+ T            PKKP+  EL+  + K P 
Sbjct: 714 KGTAPTTPKEPAPTT---PKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPT 770

Query: 134 LGATPFPRKPLQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARPPSEPKSGAFPRKLW 193
              +  P      E   AP     P P  P +KP      + P  PP      + P    
Sbjct: 771 STTSDKPAPTTPKET--APTTPKEPAPTTP-KKPAP----TTPETPPPTTSEVSTPTTTK 823

Query: 194 QPEAGEATPRSPQPELSTFPKKPAQPEFNVYPKKPPQPQVGGLPKKSVPQPEFSEAAQTP 253
           +P     +P    PELS      A+P        P +P V      +  +PE +  A+  
Sbjct: 824 EPTTIHKSPDESTPELS------AEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDK 877

Query: 254 LWKPQSSEPKRDSSAFPKKASQPPLSDFPKKPPQPELGDLTRTSSEPEVSVLPKRPRPAE 313
             +         ++A PK   +   +   +K  + +   +T T+++   S   +   P +
Sbjct: 878 TTERDLRTTPETTTAAPKMTKETATT--TEKTTESK---ITATTTQ-VTSTTTQDTTPFK 931

Query: 314 FKALSKKPPQPELGGLPRTSSEPEFNSLPRKLLQPERRGPPRKFSQPEPSAVLKRHPQP 372
              L      P++    +T +  E  + P +  +P+ R    K + P+P    K   +P
Sbjct: 932 ITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKP 990



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 76/341 (22%), Positives = 123/341 (36%), Gaps = 48/341 (14%)

Query: 26   QPEPSDLPKKP-PKPEFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPPPEVTDLPKKPP 84
            +P P+  PK+P P    G      +      PKK    E    + K P    +D P    
Sbjct: 723  EPAPTT-PKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTT 781

Query: 85   PPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPSKLELSDLSKKFPQLGATPFPRKP- 143
            P E      K P P     PKKP P      P   S++     +K+   +  +P    P 
Sbjct: 782  PKETAPTTPKEPAPTT---PKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPE 838

Query: 144  LQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARPPSEPKSGAFPRKLWQPEAGEATPR 203
            L  E     L+ S  EPG P  K                                  TP 
Sbjct: 839  LSAEPTPKALENSPKEPGVPTTK----------------------------------TPA 864

Query: 204  SPQPELSTFPK-KPAQPEFNVYPK-KPPQPQVGGLPKKSVPQPEFSEAAQTPLWKPQSSE 261
            + +PE++T  K K  + +    P+     P++    + +    + +E+  T      +S 
Sbjct: 865  ATKPEMTTTAKDKTTERDLRTTPETTTAAPKM--TKETATTTEKTTESKITATTTQVTST 922

Query: 262  PKRDSSAFPKKASQPPLSDFPKKPPQPELGDLTRTSSEPEVSVLPKRPRPAEFKALSKKP 321
              +D++ F K  +    +  PK     +    T   ++PE +  PK  R    KA + KP
Sbjct: 923  TTQDTTPF-KITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPK-DRATNSKATTPKP 980

Query: 322  PQPELGGLPRTSSEPEFNSLPRKLLQPERRGPPRKFSQPEP 362
             +P       TS++    ++PR + +P+    PRK +   P
Sbjct: 981  QKPTKAPKKPTSTKKP-KTMPR-VRKPKTTPTPRKMTSTMP 1019


>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
          Length = 1404

 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 127/566 (22%), Positives = 193/566 (34%), Gaps = 94/566 (16%)

Query: 28  EPSDLPKKPPKPEFGKLKKFSQPELSEHPKKAPLPEFGAVSL-KPPPPEVTDLPKKPPPP 86
           EP+    K P P   K    S P   + P  AP     A +  K P P  T  P    P 
Sbjct: 357 EPASTTPKEPTPTTIK----SAPTTPKEP--APTTTKSAPTTPKEPAPTTTKEPAPTTPK 410

Query: 87  EVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPSKLELSDLSKKFPQLGATPFPRKPLQP 146
           E      K P P  T      P       PKKP+     + +   P+      P++P   
Sbjct: 411 EPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPT 470

Query: 147 EVGEAPLKASLPEPGAPAR------------KPLQPDELSHPARPPSEPKSGA------F 188
               AP     P P AP +             P +P   +     P+ PK  A       
Sbjct: 471 TKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSA 530

Query: 189 PRKLWQP-----EAGEATPRSPQPELS-----TFPKKPAQPEFNVYPKKP----PQPQVG 234
           P    +P     ++   TP+ P P  +     T PK+PA       PKKP    P+    
Sbjct: 531 PTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAP----TTPKKPAPTTPKEPAP 586

Query: 235 GLPKKSVPQPEFSEAAQTPLWKPQSSEPKRDSSAFPKKAS----QPPLSDFPKKPPQPEL 290
             PK+  P      A  TP  +P  + PK  +   PKK +    +      P+KP     
Sbjct: 587 TTPKEPAPTTTKKPAPTTPK-EPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTP 645

Query: 291 GDLTRTSSEPEVSVLPKRPRPAEFKALSKKPPQPELGGLPR----TSSEPEFNSLPRKLL 346
            +L  T+ E      P+ P P   KA +   P+      P+    T+ +    + P++  
Sbjct: 646 EELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETA 705

Query: 347 QPERRG-PPRKFSQPEPSAVLKRHPQPEFFGDLPRKPPLPSSASESSLPAAVAGFSSRHP 405
               +G  P    +P P+   K  P P+       K P  S+  +   P    G +   P
Sbjct: 706 PTTPKGTAPTTLKEPAPTTPKK--PAPKELAPTTTKEP-TSTTCDKPAPTTPKGTAPTTP 762

Query: 406 LSPGFGAAGTPRWRSGGLVHSGGARPGLR-PSHPPRRRPLP----------PASSLGHPP 454
             P   A  TP+         G A   L+ P+    ++P P          P S+    P
Sbjct: 763 KEP---APTTPK-EPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKP 818

Query: 455 A------------KPPLPPGPVDMQSFRRPSAASIDLRRTRSAAGLHFQDRQPEDIPVPD 502
           A            K P P  P      ++P+  + +     ++     +   P     P 
Sbjct: 819 APTTPKETAPTTPKEPAPTTP------KKPAPTTPETPPPTTS-----EVSTPTTTKEPT 867

Query: 503 EIYELYDDVEPRDDSSPSPKGRDEAP 528
            I++  D+  P   + P+PK  + +P
Sbjct: 868 TIHKSPDESTPELSAEPTPKALENSP 893



 Score = 84.3 bits (207), Expect = 3e-16
 Identities = 141/637 (22%), Positives = 208/637 (32%), Gaps = 111/637 (17%)

Query: 28   EPSDLPKKPPKPEFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPPPEVTDLPKKPPPPE 87
            EP+    K P P   K    +  E +    K P P          P E      K P P 
Sbjct: 450  EPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPT 509

Query: 88   VTD-----LPKKPPPPEVTDLPK--KPPPPEVTD----LPKKPSKLELSDLSKKFPQLGA 136
             T       PK+P P      P   K P P  T      PK+PS     + +   P+  A
Sbjct: 510  TTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPA 569

Query: 137  TPFPRKPLQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARPPSEPKSGA--FPRKLWQ 194
               P+KP  P   + P   +  EP     K   P     PA  P+ PK  A   P+KL  
Sbjct: 570  PTTPKKPA-PTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPA--PTTPKETAPTTPKKLTP 626

Query: 195  PEAGEATPRSPQPELSTFPKK--PAQPE--FNVYPKKP----PQPQVGGLPKKSVPQPEF 246
                +  P +P+    T P++  P  PE      P++P    P+      PK+  P    
Sbjct: 627  TTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPK 686

Query: 247  SEAAQTPLWKPQSSEPKRDSSAFPKKAS----QPPLSDFPKKPPQPELGDLTR------- 295
              A  TP  +P  + PK  +   PK  +    + P    PKKP   EL   T        
Sbjct: 687  EPAPTTPK-EPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTT 745

Query: 296  ------TSSEPEVSVLPKRPRPAEFKALSKKPPQPELGGLPRTSSEPEFNS----LPRKL 345
                  T+ +      PK P P   K  +   P+   G  P T  EP   +     P++L
Sbjct: 746  CDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPK---GTAPTTLKEPAPTTPKKPAPKEL 802

Query: 346  LQPERRGP-------PRKFSQPEPSAVLKRHPQPEFFGDLPRKPPL------PSSASESS 392
                 +GP       P   +  E +    + P P      P+KP        P + SE S
Sbjct: 803  APTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPT----TPKKPAPTTPETPPPTTSEVS 858

Query: 393  LPAAVAGFSSRHPL----SPGFGAAGTPRWRSGGLVHSGGARPGLRPSHPPRRRPLPPAS 448
             P      ++ H      +P   A  TP+      + +    PG+  +  P        +
Sbjct: 859  TPTTTKEPTTIHKSPDESTPELSAEPTPK-----ALENSPKEPGVPTTKTPAATKPEMTT 913

Query: 449  SLGH----------PPAKPPLPPGPVDMQSFRRPSAASIDLRRTRSAAGLHFQDRQPEDI 498
            +             P      P    +  +    +  S     T        QD  P  I
Sbjct: 914  TAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKI 973

Query: 499  PV-------------------------PDEIYELYDDVEPRDDSSPSPKGRDEAPSVQQA 533
                                       P+E  +  D       ++P P+   +AP    +
Sbjct: 974  TTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTS 1033

Query: 534  ARRPPQDPALRKEK-DPQPQQLPPMDPKLLKQLRKAE 569
             ++P   P +RK K  P P+++    P+L    R AE
Sbjct: 1034 TKKPKTMPRVRKPKTTPTPRKMTSTMPELNPTSRIAE 1070



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 125/561 (22%), Positives = 201/561 (35%), Gaps = 101/561 (18%)

Query: 40  EFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPPPEVTDLPKKPPPPE----VTDLPKKP 95
           E   ++K S  +L+   K    P   A +    P   T  PK+P P       +  PK+P
Sbjct: 309 ETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTT--PKEPTPTTPKEPASTTPKEP 366

Query: 96  PPPEVTDLP---KKPPPPEVTDLPKKPSKLELSDLSKKFPQLGATPFP---RKPLQPEVG 149
            P  +   P   K+P P      P  P +   +   +  P     P P   ++P      
Sbjct: 367 TPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTK 426

Query: 150 EAPLKASLPEPGAPAR----KPLQPDELSHPARPPSEPKSGAFPRKLWQPEAGEATPRSP 205
            AP     P P  P +     P +P   +     P+ PK  A       P   E  P +P
Sbjct: 427 SAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPA-------PTTKEPAPTTP 479

Query: 206 QPELSTFPKKPAQPEFNVYPKKP-------PQPQVGGLPKKSVPQ---PEFSEAAQTPLW 255
           +    T PKKPA       PK+P       P P     P  + P+   P  +++A T   
Sbjct: 480 KEPAPTAPKKPAP----TTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTK 535

Query: 256 KPQSSEPKRDSSAFPKKAS----QPPLSDFPKKPPQPELGDLTRTSSEPEVSVLPKRPRP 311
           +P  +  K  +   PK+ S    + P    PK+P          T+ +      PK P P
Sbjct: 536 EPAPTTTK-SAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAP 594

Query: 312 AEFKALSKKPPQPELGGLPRTSSEPEFNSLPRKL--LQPERRGPPRKFSQPEPSAVLKRH 369
              K  +   P+      P+ ++     + P+KL    PE+  P     +P P+      
Sbjct: 595 TTTKKPAPTTPKEPAPTTPKETAP----TTPKKLTPTTPEKLAPTTP-EKPAPTT----- 644

Query: 370 PQPEFFGDLPRKPPLPSSASE--SSLPAAVAGFSSRH--PLSPGFGAAGTPRWRSGGLVH 425
             PE       + P P++  E   + P A A  + +   P +P   A  TP+  +     
Sbjct: 645 --PEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPA----- 697

Query: 426 SGGARPGLRPSHPPRRRPLPP----ASSLGHPPAKPPLPPGPVDM--QSFRRPSAASIDL 479
                    P+ P    P  P     ++L  P    P  P P ++   + + P++ + D 
Sbjct: 698 ---------PTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDK 748

Query: 480 RRTRSAAGLHFQDRQPEDIPVPDEIYELYDDVEPRDDSSPSPKGRDEAPSVQQAARRPPQ 539
               +  G       P++ P P           P++ +  +PKG   AP+         +
Sbjct: 749 PAPTTPKGT--APTTPKE-PAP---------TTPKEPAPTTPKG--TAPTTL-------K 787

Query: 540 DPALRKEKDPQPQQLPPMDPK 560
           +PA    K P P++L P   K
Sbjct: 788 EPAPTTPKKPAPKELAPTTTK 808



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 77/359 (21%), Positives = 124/359 (34%), Gaps = 34/359 (9%)

Query: 26   QPEPSDLPKKPPKPEFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPPPEVTDLPKKPPP 85
            +P P+   +  P    G      +      PKK    E    + K P     D P    P
Sbjct: 695  EPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTP 754

Query: 86   PEVTDLPKKPPPPEVTDLPKKPPP--PEVT----------DLPKKPSKLELSDLSKKFPQ 133
                    K P P     PK+P P  P+ T            PKKP+  EL+  + K P 
Sbjct: 755  KGTAPTTPKEPAPTT---PKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPT 811

Query: 134  LGATPFPRKPLQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARPPSEPKSGAFPRKLW 193
               +  P      E   AP     P P  P +KP      + P  PP      + P    
Sbjct: 812  STTSDKPAPTTPKET--APTTPKEPAPTTP-KKPAP----TTPETPPPTTSEVSTPTTTK 864

Query: 194  QPEAGEATPRSPQPELSTFPKKPAQPEFNVYPKKPPQPQVGGLPKKSVPQPEFSEAAQTP 253
            +P     +P    PELS      A+P        P +P V      +  +PE +  A+  
Sbjct: 865  EPTTIHKSPDESTPELS------AEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDK 918

Query: 254  LWKPQSSEPKRDSSAFPKKASQPPLSDFPKKPPQPELGDLTRTSSEPEVSVLPKRPRPAE 313
              +         ++A PK   +   +   +K  + +   +T T+++   S   +   P +
Sbjct: 919  TTERDLRTTPETTTAAPKMTKETATT--TEKTTESK---ITATTTQ-VTSTTTQDTTPFK 972

Query: 314  FKALSKKPPQPELGGLPRTSSEPEFNSLPRKLLQPERRGPPRKFSQPEPSAVLKRHPQP 372
               L      P++    +T +  E  + P +  +P+ R    K + P+P    K   +P
Sbjct: 973  ITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKP 1031



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 76/341 (22%), Positives = 123/341 (36%), Gaps = 48/341 (14%)

Query: 26   QPEPSDLPKKP-PKPEFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPPPEVTDLPKKPP 84
            +P P+  PK+P P    G      +      PKK    E    + K P    +D P    
Sbjct: 764  EPAPTT-PKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTT 822

Query: 85   PPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPSKLELSDLSKKFPQLGATPFPRKP- 143
            P E      K P P     PKKP P      P   S++     +K+   +  +P    P 
Sbjct: 823  PKETAPTTPKEPAPTT---PKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPE 879

Query: 144  LQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARPPSEPKSGAFPRKLWQPEAGEATPR 203
            L  E     L+ S  EPG P  K                                  TP 
Sbjct: 880  LSAEPTPKALENSPKEPGVPTTK----------------------------------TPA 905

Query: 204  SPQPELSTFPK-KPAQPEFNVYPK-KPPQPQVGGLPKKSVPQPEFSEAAQTPLWKPQSSE 261
            + +PE++T  K K  + +    P+     P++    + +    + +E+  T      +S 
Sbjct: 906  ATKPEMTTTAKDKTTERDLRTTPETTTAAPKM--TKETATTTEKTTESKITATTTQVTST 963

Query: 262  PKRDSSAFPKKASQPPLSDFPKKPPQPELGDLTRTSSEPEVSVLPKRPRPAEFKALSKKP 321
              +D++ F K  +    +  PK     +    T   ++PE +  PK  R    KA + KP
Sbjct: 964  TTQDTTPF-KITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPK-DRATNSKATTPKP 1021

Query: 322  PQPELGGLPRTSSEPEFNSLPRKLLQPERRGPPRKFSQPEP 362
             +P       TS++    ++PR + +P+    PRK +   P
Sbjct: 1022 QKPTKAPKKPTSTKKP-KTMPR-VRKPKTTPTPRKMTSTMP 1060


>gi|163965366 nascent polypeptide-associated complex alpha subunit
            isoform a [Homo sapiens]
          Length = 2078

 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 133/515 (25%), Positives = 164/515 (31%), Gaps = 90/515 (17%)

Query: 27   PEPSDLPKKP----PKPEFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPPPEVTDLPKK 82
            P P   P  P    P P+         P  +  PK A  P           P  T LPK 
Sbjct: 1003 PSPKGAPTPPAVTPPSPK-------GSPAATPFPKGASTPPAATPPSPKGSPAATPLPKG 1055

Query: 83   PPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPSKLELSDLSKKFPQLGATPFPRK 142
             P      LP     P    L   P PP  T    K      S      P     P P+ 
Sbjct: 1056 APTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPKG 1115

Query: 143  PL--QPEVGEAPLKASLP--------------EPGAPARKPLQP----------DELSHP 176
             L   P  G     A+ P               P  PA  P  P             + P
Sbjct: 1116 GLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPPPKGAPTTP 1175

Query: 177  ARPPSEPKSG-AFPRKLWQPEAGEATPRSPQPELSTFPKKPAQPEFNVYPKKPPQPQVGG 235
            A  P  PK G A P     P    ATP SP+  L+T   K A          PP P+ GG
Sbjct: 1176 AATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAP---TTPAATPPSPK-GG 1231

Query: 236  LPKKSVPQPEFSEAAQTPLWKPQSSEPKRDSSAFPKKASQPP----LSDFPKK------- 284
            L   S      + AA  P  K   + P    +  P  A+ P     L+  P K       
Sbjct: 1232 LATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGLATPPHKGAPNPAV 1291

Query: 285  --PPQPELGDLTRTSSEPEVSVLPKRPRPAEFKALSKKPPQPELGGLPRTSSEPEFNSLP 342
              PP P+ G  T   S P+ +  P    P   K     PP P+    P   + P     P
Sbjct: 1292 VTPPSPKGGPAT---SPPKGAPTPPAATPPSPKGSPGTPP-PKGAPTPPAVTPPSPKGTP 1347

Query: 343  R-KLLQPERRGPPRKFSQPE----PSAVLKRHPQPEFFGDLPRK-PPLPSSASESSLPAA 396
                  P  +G P   S  E    P+A       P      P++ P +PS   + + PA 
Sbjct: 1348 TLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPKRGPAIPSPKGDPTSPAV 1407

Query: 397  VAGFSSRHPLSPGFGAAGTPRWRSGGLVHSGG--ARPGLRP--------SHPPRRRPLPP 446
            +       PLSP   A  TP  R G    S G    P + P        +  P+  P  P
Sbjct: 1408 I-------PLSPK-KAPATPVTREGAATPSKGDLTPPAVTPVSLKKAPATSAPKGGPATP 1459

Query: 447  ASSLGHP------PAKPPLPPGPVDMQSFRRPSAA 475
             SS G P      P  P  PP P  + +   P  A
Sbjct: 1460 -SSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKA 1493



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 128/501 (25%), Positives = 157/501 (31%), Gaps = 98/501 (19%)

Query: 66   AVSLKPPPPEVTDLPKKPPPPE-VTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPSKLEL 124
            A +  P PP     PK  P P  VT L     P  VT  PK+ P P V +LP        
Sbjct: 851  ATTHSPTPPS----PKGAPTPSAVTPLS----PKGVTLPPKETPTPSVVNLP-------- 894

Query: 125  SDLSKKFPQLG-ATPFPRK-PLQPEVGEAPLKA-SLPEPGAPARKPLQPDELSHPARPPS 181
                  FP+ G ATP P++ P       +P KA + P P      P      + PA  P 
Sbjct: 895  ------FPKEGPATPAPKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAATPP 948

Query: 182  EPKSG-AFPRKLWQPEAGEATPRSPQPELSTFPKKPAQPEFNVYPKKPPQPQVGGLPKKS 240
             PK G A P   W P    ATP SP+         PA P     PK  P P     P  +
Sbjct: 949  SPKGGPATPSPKWAPTPPAATPPSPKGG-------PATPS----PKGAPTP-----PAAT 992

Query: 241  VPQPEFSEAAQTPLWKPQSSEPKRDSSAFPKKASQPPLSDFPKKPPQPELGDLTRTSSEP 300
             P P+   A  +P                 K A  PP    P     P      + +S P
Sbjct: 993  PPSPKGGPATPSP-----------------KGAPTPPAVTPPSPKGSPAATPFPKGASTP 1035

Query: 301  EVSVLPKRPRPAEFKALSKKPPQPELGGLPRTSSEPEFNSLPRKLLQPERRGPPRKFSQP 360
              +  P          L K  P      LP     P   SL      P    P  K    
Sbjct: 1036 PAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPA 1095

Query: 361  EPSAVLKRHPQPEFFGDLPRKPPLPSSASESSLPAAVAGFSSRHPLSPGFGAAGTPRWRS 420
             PS               P+  P+P +A+  S    +A  +  H  +P   AA TP    
Sbjct: 1096 TPS---------------PKGAPMPPAATPPSPKGGLA--TPPHKGAPTTPAA-TPPSPK 1137

Query: 421  GGLV----HSGGARPGLRPSHPPRRRPLPPASSLGHPPAKPPLPPGPVDMQSFRRPSAAS 476
            GGL           P   P  P      PP    G P      PP P    +   P  A 
Sbjct: 1138 GGLATPPPKGAPTTPAATPPSPKGGLATPPPK--GAPTTPAATPPSPKGGLATPSPKGAP 1195

Query: 477  IDLRRTRSAAGLHFQDRQPEDIPVPDEIYELYDDVEPRDDSSPSPKGRDEAPSVQQAARR 536
                 T  +         P+  P                 + PSPKG    PS + A   
Sbjct: 1196 TTPAATPPSPKGGLATPSPKGAPTTPAA------------TPPSPKGGLATPSPKGAPTT 1243

Query: 537  PPQDPALRK--EKDPQPQQLP 555
            P   P   K     P P+  P
Sbjct: 1244 PAATPPSPKGGPATPPPKGAP 1264



 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 95/350 (27%), Positives = 121/350 (34%), Gaps = 54/350 (15%)

Query: 57   KKAPLPEFGAVSLKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLP 116
            KK P       +L PP   V    K P  P   + P  P   E +       PP VT   
Sbjct: 1536 KKTPATLAPKEALIPPAMTVPSPKKTPAIPTPKEAPATPSSKEASS------PPAVTPST 1589

Query: 117  KK--PSKLEL---SDLSKKFPQLGATPFPRKPLQPEVGEAPLKASLPEP-GAPARKPLQP 170
             K  PS  EL     ++   P+   TP    P  PE G A      P P G P   P+ P
Sbjct: 1590 YKGAPSPKELLIPPAVTSPSPKEAPTPPAVTPPSPEKGPA-----TPAPKGTPTSPPVTP 1644

Query: 171  DELSHPARPPSEPKSGAFPRKLWQPEAGEATPRSPQPELSTFPKKPAQPEFNVYPKKPPQ 230
              L      P+ P S         P+A +  P    P         A  E  V P     
Sbjct: 1645 SSLKD---SPTSPASVTCKMGATVPQASKGLPAKKGP--------TALKEVLVAPAPEST 1693

Query: 231  PQVGGLPKKSVPQPEFSEAAQTPLWKPQSSEPKRDSSAFPKKASQPPLSDFPKKPPQPEL 290
            P +   P +  PQ + S A   P+    S+          K  S+ PLS     P  P  
Sbjct: 1694 PIITA-PTRKGPQTKKSSATSPPICPDPSA----------KNGSKGPLSTVAPAPLLPVQ 1742

Query: 291  GDLTRTSSEPEVSVLPKRP-RPAEFK--------ALSKKPPQPELGGLPRTSSEPEFNSL 341
             D ++T+   + S  PK P  P E K        A  K  P+PE   +    S P   SL
Sbjct: 1743 KDSSKTAKGKDASHSPKGPLAPPESKASTPLTAAAFEKVLPKPESASVSAAPSPPV--SL 1800

Query: 342  PRKLLQPERRGPPRKFSQPEPSAVLKRHPQPEFFGD----LPRKPPLPSS 387
            P          P ++F    P  VL+   +P    D    LP  PP P S
Sbjct: 1801 PLAPSPVPTLPPKQQFLPSSPGLVLESPSKPLAPADEDELLPLIPPEPIS 1850



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 137/595 (23%), Positives = 188/595 (31%), Gaps = 107/595 (17%)

Query: 32   LPKKPPKPEFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPP--PEVTDLPKKPPP---P 86
            +P  PP P+   LK      L + P +  L    A SL+  P  P    L  K  P   P
Sbjct: 503  IPVSPPLPDPEDLKNLPSSVLVKFPTQKDLQTVPA-SLEGAPFSPAQAGLTTKKDPTVLP 561

Query: 87   EVTDLPKKPPPPEVTDL-PKKPPPPEVTDLPK---------KPSKLELSDL--------- 127
             V   PK  P  + T   P+ P  PE T   K         KP+    S L         
Sbjct: 562  LVQAAPKNSPSFQSTSSSPEIPLSPEATLAKKSLGEPLPIGKPASSMTSPLGVNSSASVI 621

Query: 128  ---SKKFPQLGATPFPRKPLQPEVGEAPLKASLPEPGAPAR-----------KPLQPDEL 173
               S   P           + P V   PL+++ P   AP              P     +
Sbjct: 622  KTDSYAGPDSAGPLLKSSLITPTVAAFPLESADPAGVAPTTAKGTSTYTTTASPFLEGTV 681

Query: 174  SHPARPPSEP-KSGAFPRKLWQPEAGEATPRSPQPE-----LSTFPKKPAQPEFNVYPKK 227
            S    P + P K G        P A E  P +P P+     L+T    P  P+    P  
Sbjct: 682  S--LAPKNHPVKEGTLTTLPLVPTASENCPVAPSPQNTCAPLATLVLAPEIPKSVPSPSL 739

Query: 228  PPQ------PQVGGLPKKSVPQPEFSEAAQTPLWKPQSSEPKRDSSAFPKKASQPP---- 277
            PP        +V G+   S   P  S   + P     +S            A  P     
Sbjct: 740  PPAGTPPGTKKVDGISHTSALAPVASSPKECPTEDSGASATASSKGTLTYLADSPSPLGV 799

Query: 278  -LSDFPKKPPQPE--------LGDLTRTSSEPEVSVLPKRPRP----AEFKALSKKPPQP 324
             +S   K+PP  +        +G+L+   S  E S LP+         +  A +  P  P
Sbjct: 800  SVSPQTKRPPTKKGSAGPDTPIGNLSSPVSPVEASFLPENSLSFQGSKDSPATTHSPTPP 859

Query: 325  ELGGLPRTSSEPEFNSLPRKLLQPERRGPPRKFSQPEPSAVLKRHPQPEFFGDLPRKPPL 384
               G P  S+    +  P+ +  P +         P PS V    P+       P++ P 
Sbjct: 860  SPKGAPTPSAVTPLS--PKGVTLPPKE-------TPTPSVVNLPFPKEGPATPAPKQAPA 910

Query: 385  PSSASESSLPAAVAGFSSRHPLSPGFGAAGTPRWRSGGLVHSGGARPGLRPSHPPRRRPL 444
             S  S S   A         P SP    A TP   +      G A P       P+  P 
Sbjct: 911  LSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAATPPSPKGGPATPS------PKWAPT 964

Query: 445  PPASSLGHPPAKPPLPPGPVDMQSFRRPSAASIDLRRTRSAAGLHFQDRQPEDIPVPDEI 504
            PPA++   P   P  P      +    P AA+    +   A         P+  P P  +
Sbjct: 965  PPAATPPSPKGGPATP----SPKGAPTPPAATPPSPKGGPATP------SPKGAPTPPAV 1014

Query: 505  YELYDDVEPRDDSSPSPKGRDEAPSVQQAARRPPQDPALRKEKDPQPQQLPPMDP 559
                        + PSPKG   A    + A  PP       +  P    LP   P
Sbjct: 1015 ------------TPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGAP 1057



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 105/477 (22%), Positives = 151/477 (31%), Gaps = 47/477 (9%)

Query: 24   ASQPEPSDLPKKPPKPEFGKLKKFSQPELSEHPKKAPLPEFGAVS---LKPPPPE---VT 77
            A+ P P   P  PP P+       + P   +     P P  GA +   + PP P+    T
Sbjct: 1246 ATPPSPKGGPATPP-PKGAPTPPAATPPSLKGGLATP-PHKGAPNPAVVTPPSPKGGPAT 1303

Query: 78   DLPKKPPPPEVTDLPKKP-----PPPEVTDLPKKPPPPEVTDLPKKPSKLELSDLSKKFP 132
              PK  P P     P        PPP+    P    PP     P  P+    S      P
Sbjct: 1304 SPPKGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTPPSPKGTPTLPATTPSSKGGPTTP 1363

Query: 133  QLGATPFPRKPLQPEVGEAPLKASLPEPG----APARKPLQPDELSHPARPPSEPKSGAF 188
                 P P        G   +    P+ G    +P   P  P  +  P  P   P +   
Sbjct: 1364 SSKEGPTPPAATPSHKGGPAMTPPSPKRGPAIPSPKGDPTSPAVI--PLSPKKAPATPVT 1421

Query: 189  PRKLWQPEAGEATPRSPQP------ELSTFPKK-PAQPEFNVYPK----KPPQPQVGGLP 237
                  P  G+ TP +  P        ++ PK  PA P     P      PP P+    P
Sbjct: 1422 REGAATPSKGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAP 1481

Query: 238  KKSVPQPEFSEAAQTPLWKPQSSEPKRDSSAFPKKASQPPLSDFPKKPPQPELGDLTRTS 297
            K+        +A  TP      + P    S+  +  + P     P  P    L   T  +
Sbjct: 1482 KQVATSSSPKKAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKKTPAT 1541

Query: 298  SEPEVSVLPKR---PRPAEFKALSKKPPQPELGGLPRTSSEPEFNSL-------PRKLLQ 347
              P+ +++P     P P +  A+      P        SS P            P++LL 
Sbjct: 1542 LAPKEALIPPAMTVPSPKKTPAIPTPKEAPATPSSKEASSPPAVTPSTYKGAPSPKELLI 1601

Query: 348  PERRGPPRKFSQPEPSAVLKRHPQPEFFGDLPRKPPLPSSASESSL---PAAVAGFSSRH 404
            P     P     P P AV    P+       P+  P     + SSL   P + A  + + 
Sbjct: 1602 PPAVTSPSPKEAPTPPAVTPPSPEKGPATPAPKGTPTSPPVTPSSLKDSPTSPASVTCKM 1661

Query: 405  PLSPGFGAAGTPRWRSGGLVHSGGARPGLRP----SHPPRRRPLPPASSLGHPPAKP 457
              +    + G P  +    +      P        + P R+ P    SS   PP  P
Sbjct: 1662 GATVPQASKGLPAKKGPTALKEVLVAPAPESTPIITAPTRKGPQTKKSSATSPPICP 1718



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 85/346 (24%), Positives = 122/346 (35%), Gaps = 86/346 (24%)

Query: 53   SEHPKKAPLPEFGAVSLKPPPPE---VTDLPKKPP------PPEVTDLPKKPP------- 96
            S  PK+AP P     ++ PP PE    T  PK  P      P  + D P  P        
Sbjct: 1607 SPSPKEAPTPP----AVTPPSPEKGPATPAPKGTPTSPPVTPSSLKDSPTSPASVTCKMG 1662

Query: 97   ---PPEVTDLPKKPPPP---EVTDLPKKPSKLELSDLSKKFPQLGATPFPRKPLQPEVG- 149
               P     LP K  P    EV   P   S   ++  ++K PQ   +     P+ P+   
Sbjct: 1663 ATVPQASKGLPAKKGPTALKEVLVAPAPESTPIITAPTRKGPQTKKSSATSPPICPDPSA 1722

Query: 150  ----EAPLKASLPEPGAPARKP----LQPDELSH----PARPPSEPKS-----GAFPRKL 192
                + PL    P P  P +K      +  + SH    P  PP    S      AF + L
Sbjct: 1723 KNGSKGPLSTVAPAPLLPVQKDSSKTAKGKDASHSPKGPLAPPESKASTPLTAAAFEKVL 1782

Query: 193  WQPEAGEAT---------PRSPQPELSTFPKK-------------PAQP-----EFNVYP 225
             +PE+   +         P +P P  +  PK+             P++P     E  + P
Sbjct: 1783 PKPESASVSAAPSPPVSLPLAPSPVPTLPPKQQFLPSSPGLVLESPSKPLAPADEDELLP 1842

Query: 226  KKPPQPQVGGLPKKSV----PQPEFSEAAQTPLWKPQSSEP-----KRDSSAFPKKASQP 276
              PP+P  GG+P +SV    P P   ++A  P+  P + +P     K   +      S P
Sbjct: 1843 LIPPEPISGGVPFQSVLVNMPTP---KSAGIPVPTPSAKQPVTKNNKGSGTESDSDESVP 1899

Query: 277  PLSD---FPKKPPQPELGDLTRTSSEPEVSVLPKRPRPAEFKALSK 319
             L +         Q +L        EP       R      KA+SK
Sbjct: 1900 ELEEQDSTQATTQQAQLAAAAEIDEEPVSKAKQSRSEKKARKAMSK 1945



 Score = 39.3 bits (90), Expect = 0.012
 Identities = 105/496 (21%), Positives = 158/496 (31%), Gaps = 107/496 (21%)

Query: 156 SLPEPGAPARK--PLQPDELSHPARPPSEPKSGAFPRKLWQPEAGEATPRSPQPELSTFP 213
           +LP P +PA +  PL     + P   PS   S        Q  +G A P    PE  TF 
Sbjct: 44  TLPPPCSPAPQQCPLSAANQASPFPSPSTIASTPLEVPFPQSSSGTALPLGTAPEAPTFL 103

Query: 214 KK----PAQPEFNVYPKKPPQPQVGGLPKKSVPQPEFSEAAQTPLWKPQSSEPKRDSSAF 269
                 P  P           P + G P  S P    + A       P S +    SSAF
Sbjct: 104 PNLIGPPISPAALALASPMIAPTLKGTPSSSAPLALVALA-------PHSVQ---KSSAF 153

Query: 270 PKKASQPPLSDFPKKPPQPELGDLTRTSSEPEVSVLPKRPRPAEFKALSKKPPQPE---- 325
           P     P L   P      E G +   S+     + P  P+    K  S+  P P+    
Sbjct: 154 P-----PNLLTSPPSVAVAESGSVITLSA----PIAPSEPKTNLNKVPSEVVPNPKGTPS 204

Query: 326 ----------------------LGGLPRT---------SSEPEFNSLPRKLLQPERRG-- 352
                                 +  LP+T         S + +  ++   L+ P+  G  
Sbjct: 205 PPCIVSTVPYHCVTPMASIQSGVASLPQTTPTTTLAIASPQVKDTTISSVLISPQNPGSL 264

Query: 353 -------PPRKFSQPEPSAVLKRHPQPEFFGDLPRKPPLPSSASESSLPAAVAGFSSRHP 405
                  PP   S    S  +    Q     + P  P  P S      P   + F S   
Sbjct: 265 SLKGPVSPPAALSLSTQSLPVVTSSQKTAGPNTP--PDFPISLGSHLAPLHQSSFGSVQL 322

Query: 406 L-SPGFGAAGTPRWRSGGLVHS--GGARPGLRPSHP--PRRRPLPPASSLGHPPAKPPLP 460
           L   G  A   P  ++  + HS  G + P  R   P  P R  + PA+    P   P + 
Sbjct: 323 LGQTGPSALSDPTVKTISVDHSSTGASYPSQRSVIPPLPSRNEVVPATVAAFPVVAPSVD 382

Query: 461 PGPVDMQSFRRPSAASIDLRRT-----------RSAAGLHFQDRQPEDIPV--------- 500
            GP  + S     + S+++  +           +S+    +       +PV         
Sbjct: 383 KGPSTISSITCSPSGSLNVATSFSLSPTTSLILKSSPNATYHYPLVAQMPVSSVGTTPLV 442

Query: 501 ----------PDEIYELYDDVEPRDDSSPSPKGRDEAPSVQQAARRPPQDPALRKEKDPQ 550
                     P   +E+   V P   S P       +P+    A   P++P+ +     +
Sbjct: 443 VTNPCTIAAAPTTTFEVATCVSPPMSSGPISNIEPTSPAALVMAPVAPKEPSTQVATTLR 502

Query: 551 PQQLPPM-DPKLLKQL 565
               PP+ DP+ LK L
Sbjct: 503 IPVSPPLPDPEDLKNL 518



 Score = 37.4 bits (85), Expect = 0.045
 Identities = 44/150 (29%), Positives = 54/150 (36%), Gaps = 22/150 (14%)

Query: 24   ASQPEPSDLPKKPPKPEFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPPPEVTDLPKKP 83
            A   + S  PK P  P   K    +    +   K  P PE  +VS  P PP    LP  P
Sbjct: 1749 AKGKDASHSPKGPLAPPESKAS--TPLTAAAFEKVLPKPESASVSAAPSPP--VSLPLAP 1804

Query: 84   PPPEVTDLPKK-----PPPPEVTDLPKKPPPPEVTDLPKKPSKLELSDLSKKFPQLGATP 138
             P  V  LP K       P  V + P KP  P   D        EL  L    P  G  P
Sbjct: 1805 SP--VPTLPPKQQFLPSSPGLVLESPSKPLAPADED--------ELLPLIPPEPISGGVP 1854

Query: 139  FPRKPLQPEVGEAPLKASLPEPGAPARKPL 168
            F    +       P  A +P P   A++P+
Sbjct: 1855 FQSVLVNM---PTPKSAGIPVPTPSAKQPV 1881


>gi|19718731 bromodomain-containing protein 4 isoform long [Homo
            sapiens]
          Length = 1362

 Score = 84.3 bits (207), Expect = 3e-16
 Identities = 136/573 (23%), Positives = 200/573 (34%), Gaps = 92/573 (16%)

Query: 7    AAMESHQDFRSIKAKFQASQPEPSDLPKKPPKPEFGKLKKFSQPELSEHPKKAPLPEFGA 66
            ++ ES     S  +  + S+ E +   KK   P  G+ +K       +  ++AP P    
Sbjct: 699  SSSESESSSESSSSDSEDSETEMAPKSKKKGHP--GREQKKHHHHHHQQMQQAPAP---- 752

Query: 67   VSLKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPSKLELSD 126
            V  +PPPP     P++PPP         PPPP+    P  PPPP     P  P +     
Sbjct: 753  VPQQPPPP-----PQQPPP---------PPPPQQQQQPPPPPPP-----PSMPQQAA--- 790

Query: 127  LSKKFPQLGATPFPRKPLQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARPPSEPKSG 186
                 P + ++P P    Q  V E  L  S+ +P     +P+    L  P  PP  P+  
Sbjct: 791  -----PAMKSSPPPFIATQVPVLEPQLPGSVFDPIGHFTQPIL--HLPQPELPPHLPQP- 842

Query: 187  AFPRKLWQPEAGEATPRSPQPELSTFPKKPAQPEFNV-----YPKKPPQPQVGGLPKKSV 241
              P     P   +    SP    +  P++P++P          P +PP           +
Sbjct: 843  --PEHSTPPHLNQHAVVSPPALHNALPQQPSRPSNRAAALPPKPARPPAVSPALTQTPLL 900

Query: 242  PQPEFSEAAQTPLWKPQSSEPKRDSSAFPKKASQPPLSDFPK-KPPQPELGDLTRTSSEP 300
            PQP  ++  Q  L   +   P   S        Q  L    K +PP P L  +   S  P
Sbjct: 901  PQPPMAQPPQVLLEDEEPPAPPLTSMQM-----QLYLQQLQKVQPPTPLLPSVKVQSQPP 955

Query: 301  EVSVLPKRPRPAEFKALSKKPPQPELGGLPRTSSEPEFNSLPRKLLQPERRG---PPRKF 357
                LP  P P+  + L ++PP P     P    +P     P++  QP  R     P +F
Sbjct: 956  --PPLPPPPHPSVQQQLQQQPPPP-----PPPQPQPP----PQQQHQPPPRPVHLQPMQF 1004

Query: 358  S-----QPEPSAVLKRHPQPEFFGDLPRKPPLPSSASESSLPAAVAGFSSRHPLSPGFGA 412
            S      P P      HP P       ++PP P  A    +       S RH  S  +  
Sbjct: 1005 STHIQQPPPPQGQQPPHPPP------GQQPPPPQPAKPQQV--IQHHHSPRHHKSDPYST 1056

Query: 413  AGTPRWRSGGLVHSG--GARPGLRPSHPPRRRPLPPASSLGHPPAKPPLPPGPVDMQSFR 470
                   S  ++HS        L    PP++   P    L       P P   V  +   
Sbjct: 1057 GHLREAPSPLMIHSPQMSQFQSLTHQSPPQQNVQPKKQELRAASVVQPQPLVVVKEEKIH 1116

Query: 471  RPSAASIDLRRTRSAAGLHFQDRQPEDIPVPDEIYELYDDVEPRDDSSPSPKGRDEAPSV 530
             P   S       S +      + PE I  P  + +       R +  P   GR   P +
Sbjct: 1117 SPIIRS----EPFSPSLRPEPPKHPESIKAPVHLPQ-------RPEMKPVDVGR---PVI 1162

Query: 531  QQAARRPPQDPALRKEKDPQPQQLPPMDPKLLK 563
            +   +  P   A  K+K  Q  + P    K LK
Sbjct: 1163 RPPEQNAPPPGAPDKDKQKQEPKTPVAPKKDLK 1195



 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 134/583 (22%), Positives = 199/583 (34%), Gaps = 118/583 (20%)

Query: 10   ESHQDFRSIKAKFQASQPEPSDLPKKPPKPEFGKLKKFSQPELSEHPKKAPLPEFGAVSL 69
            E  +  +++  +  A      + PKK  K +  K K+       +H +K  + E      
Sbjct: 513  ELQEQLKAVHEQLAALSQPQQNKPKKKEKDKKEKKKE-------KHKRKEEVEENKKSKA 565

Query: 70   KPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPPPP---EVTDLPKKPSKLELSD 126
            K PPP+ T    K      +++ KK P P    +  KPPP    E  D  K  S  E   
Sbjct: 566  KEPPPKKT----KKNNSSNSNVSKKEPAP----MKSKPPPTYESEEEDKCKPMSYEEKRQ 617

Query: 127  LSKKFPQLGATPFPRKPLQPEVGEAPLKASLPEPGAPARKPLQPDELSH----------P 176
            LS    +L      R     +  E  LK S P+      + L+P  L             
Sbjct: 618  LSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTLRELERYVTSCLRK 677

Query: 177  ARPPSEPK----SGAFPRKLWQPEAGEATPRSPQPELSTFPKKPAQPEFNVYPKKPPQPQ 232
             R P   K    +G+   K +     E++  S     S+   + ++ E     KK   P 
Sbjct: 678  KRKPQAEKVDVIAGSSKMKGFSSSESESSSES-----SSSDSEDSETEMAPKSKKKGHP- 731

Query: 233  VGGLPKKSVPQPEFSEAAQTPLWKPQSSEPKRDSSAFPKKASQPPLSDFPKKPPQPELGD 292
              G  +K        +  Q P   PQ   P             PP    P  PPQ +   
Sbjct: 732  --GREQKKHHHHHHQQMQQAPAPVPQQPPP-------------PPQQPPPPPPPQQQ--- 773

Query: 293  LTRTSSEPEVSVLPKRPRPAEFKALSKKPPQPELGGLPRTSSEPEFNSLPRKLLQPERRG 352
                  +P     P  P P         P  P+       SS P F +    +L+P+  G
Sbjct: 774  -----QQP-----PPPPPP---------PSMPQQAAPAMKSSPPPFIATQVPVLEPQLPG 814

Query: 353  ----PPRKFSQPEPSAVLKRHPQPEFFGDLPRKPP--LPSSASESSL--PAAVAGFSSRH 404
                P   F+QP     +   PQPE    LP+ P    P   ++ ++  P A+     + 
Sbjct: 815  SVFDPIGHFTQP-----ILHLPQPELPPHLPQPPEHSTPPHLNQHAVVSPPALHNALPQQ 869

Query: 405  PLSPGFGAAGTPRWRSGGLVHSGGARPGLRPSHPPRRRPLPPASSLGHPPAKPPLPPGPV 464
            P  P   AA  P                 +P+ PP   P    + L     +PP+   P 
Sbjct: 870  PSRPSNRAAALPP----------------KPARPPAVSPALTQTPL---LPQPPMAQPPQ 910

Query: 465  DMQSFRRPSAASIDLRRTRSAAGLHFQDRQPEDIPVPDEIYELYDDVEPRDDSSPSPKGR 524
             +     P A  +    T     L+ Q  Q    P P     L   V+ +    P P   
Sbjct: 911  VLLEDEEPPAPPL----TSMQMQLYLQQLQKVQPPTP-----LLPSVKVQSQPPP-PLPP 960

Query: 525  DEAPSVQQAARR-PPQDPALRKEKDPQPQQLPPMDPKLLKQLR 566
               PSVQQ  ++ PP  P  + +  PQ Q  PP  P  L+ ++
Sbjct: 961  PPHPSVQQQLQQQPPPPPPPQPQPPPQQQHQPPPRPVHLQPMQ 1003



 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 132/637 (20%), Positives = 209/637 (32%), Gaps = 130/637 (20%)

Query: 23  QASQPEPSDLPKKPPKPEFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPPPEVTDLPKK 82
           QAS P  +  P+  P P           + + HP  A  P+     L    P +T +P +
Sbjct: 201 QASTPPQTQTPQPNPPPV----------QATPHPFPAVTPD-----LIVQTPVMTVVPPQ 245

Query: 83  P--PPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPSKLELSDLSKKFPQLGATPF- 139
           P   PP V   P+ PP P    +   PP    T  P K  K     + +K      T   
Sbjct: 246 PLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQPVKTKK----GVKRKADTTTPTTID 301

Query: 140 -----PRKPLQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARPPSE------------ 182
                P  P +P+  +   +     P  P +K + PD   HPA   S             
Sbjct: 302 PIHEPPSLPPEPKTTKLGQRRESSRPVKPPKKDV-PDSQQHPAPEKSSKVSEQLKCCSGI 360

Query: 183 ------PKSGAFPRKLWQPEAGEATP--------RSPQPELSTFPKKPAQPEF------- 221
                  K  A+    ++P   EA          + P  ++ST   K    E+       
Sbjct: 361 LKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPM-DMSTIKSKLEAREYRDAQEFG 419

Query: 222 --------NVYPKKPPQPQVGGLPKK----------------SVPQPEFSEAAQTPLWKP 257
                   N Y   PP  +V  + +K                  P    S  A  P  K 
Sbjct: 420 ADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVAVSSPAVPPPTKV 479

Query: 258 QSSEPKRDSSAFPKKASQPPLSDFPKKPPQ--PELGDLTRTSSEPEVSVLPKRPRPAEFK 315
            +     DSS+     S     D  ++  Q   EL +  +   E   ++   +    + K
Sbjct: 480 VAPPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQNKPKKK 539

Query: 316 ALSKKPPQPELGGLPRTSSEPEFNSLPRKLLQPERRGPPRKFSQPEPSAVLKRHPQPEFF 375
              KK  + E     +   E E N   +    P ++    K +    S V K+ P P   
Sbjct: 540 EKDKKEKKKE---KHKRKEEVEENKKSKAKEPPPKK---TKKNNSSNSNVSKKEPAP--- 590

Query: 376 GDLPRKPPLPSSASESSLPAAVAGFSSRHPLSPGFGAAGTPRWRSGGLVHSGGAR-PGLR 434
             +  KPP P+  SE         +  +  LS        P  + G +VH   +R P L+
Sbjct: 591 --MKSKPP-PTYESEEEDKCKPMSYEEKRQLSLDINK--LPGEKLGRVVHIIQSREPSLK 645

Query: 435 PSHPPR----RRPLPPA---------SSLGHPPAKPPLPPGPVDMQSFRRPSAASIDLRR 481
            S+P         L P+         +S      KP      V   S +    +S +   
Sbjct: 646 NSNPDEIEIDFETLKPSTLRELERYVTSCLRKKRKPQAEKVDVIAGSSKMKGFSSSESES 705

Query: 482 TRSAAGLHFQDRQPEDIPVPD-------EIYELYDDVEPRDDSSPSPKGRDEAPSVQQAA 534
           +  ++    +D + E  P          E  + +     +   +P+P  +   P  QQ  
Sbjct: 706 SSESSSSDSEDSETEMAPKSKKKGHPGREQKKHHHHHHQQMQQAPAPVPQQPPPPPQQ-- 763

Query: 535 RRPPQDPALRKEKDPQPQQLPPMDPKLLKQLRKAEKA 571
             PP  P  ++++ P P   PP  P + +Q   A K+
Sbjct: 764 --PPPPPPPQQQQQPPP---PPPPPSMPQQAAPAMKS 795



 Score = 35.4 bits (80), Expect = 0.17
 Identities = 39/164 (23%), Positives = 58/164 (35%), Gaps = 26/164 (15%)

Query: 70  KPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPPPPE-------VTDLPKKPSKL 122
           KP    V +  +   PP+       PPP + T  P     P+       +T +P +P  L
Sbjct: 190 KPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVMTVVPPQP--L 247

Query: 123 ELSDLSKKFPQLGATPFPRKPLQPEVGEAPLKASLPEP---------GAPARKPLQPDEL 173
           +        PQ    P P    QP     P+ A+ P+P          A    P   D +
Sbjct: 248 QTPPPVPPQPQPPPAPAP----QPVQSHPPIIAATPQPVKTKKGVKRKADTTTPTTIDPI 303

Query: 174 SHPARPPSEPKSGAFPRKLWQPEAGEATPRSPQPELSTFPKKPA 217
             P   P EPK+     KL Q        + P+ ++    + PA
Sbjct: 304 HEPPSLPPEPKT----TKLGQRRESSRPVKPPKKDVPDSQQHPA 343


>gi|24308073 protein tyrosine phosphatase, non-receptor type 23 [Homo
            sapiens]
          Length = 1636

 Score = 83.2 bits (204), Expect = 7e-16
 Identities = 165/645 (25%), Positives = 226/645 (35%), Gaps = 140/645 (21%)

Query: 70   KPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPSKLELSDLSK 129
            KPPP      P  P   E   +    PP E+  L     PP++   P+ P     S    
Sbjct: 715  KPPPRPTAPKPLLPRREESEAVEAGDPPEELRSL-----PPDMVAGPRLPDTFLGS---- 765

Query: 130  KFPQLGATP--FPRKPLQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARP-----PSE 182
                  ATP  FP  P     G  P   S P P      P Q   L  P  P     P  
Sbjct: 766  ------ATPLHFPPSPFPSSTGPGPHYLSGPLPPGTYSGPTQ---LIQPRAPGPHAMPVA 816

Query: 183  PKSGAFPRKLWQPEAGEATPRSPQPELSTFPKKPAQPEFNVYPKKPPQPQVGGLPKKSVP 242
            P    +P   + PE G     SPQ  + + P          Y    P P V GLP  S P
Sbjct: 817  PGPALYPAPAYTPELGLVPRSSPQHGVVSSP----------YVGVGPAPPVAGLP--SAP 864

Query: 243  QPEFS--------EAAQTPLWKPQSSEPKRDSSAFPKKASQPPLSDFPKKPPQPELGDLT 294
             P+FS          A T +   Q+  P   ++  P     PP   FP  PPQP      
Sbjct: 865  PPQFSGPELAMAVRPATTTVDSIQAPIPSH-TAPRPNPTPAPPPPCFPVPPPQP------ 917

Query: 295  RTSSEPEVSVLPKRPRPAEFKALSKKPPQPELGGLPRTSSEPEFNS-LPRKLLQPERRGP 353
                          P P  + A +K+P            ++  F+S +P     P R GP
Sbjct: 918  -------------LPTPYTYPAGAKQP----------IPAQHHFSSGIPAGFPAP-RIGP 953

Query: 354  PRKFSQPEPSAVLKRHPQP---EFFGDLPRKPPLPSSASESSLPAA--VAGFSSRHPLSP 408
                 QP+P      HPQP   + FG  P + PLP        P A  +    S +P +P
Sbjct: 954  -----QPQP------HPQPHPSQAFGPQPPQQPLPLQHPHLFPPQAPGLLPPQSPYPYAP 1002

Query: 409  GFGAAGTPRWRSGGLVHSGGARPGLRPSHP---PRRRPLPPASSLGHPPAKPPLPPGPVD 465
              G  G P       ++ G A+  L P+H    P   P PP       P  PPL  GP  
Sbjct: 1003 QPGVLGQPPPPLHTQLYPGPAQDPL-PAHSGALPFPSPGPP------QPPHPPLAYGPAP 1055

Query: 466  MQSFRRPSAASIDLRRTRSAA----GLHFQDRQPEDIPVPDEIYELYDDVEPRD------ 515
                  P AA + +R   SA       H     P   P P  +       EP        
Sbjct: 1056 STRPMGPQAAPLTIRGPSSAGQSTPSPHLVP-SPAPSPGPGPVPPRPPAAEPPPCLRRGA 1114

Query: 516  ------DSSP-SPKGRDEAPSVQQAARRPPQDPALRKEKDPQPQQLPPMDP-KLLKQLRK 567
                   SSP S  G  ++P   Q   +P +  A    + PQ  +L   DP +  ++LR+
Sbjct: 1115 AAADLLSSSPESQHGGTQSPGGGQPLLQPTKVDAAEGRR-PQALRLIERDPYEHPERLRQ 1173

Query: 568  AEKAEREFRKKFKFEGEIVVHTKMMIDPNAKTRRGGGKHLGIRRGEIL-----EVIEFTS 622
             ++    FR +    G +    + + D  A+     G+ + I R   L     +V+ + S
Sbjct: 1174 LQQELEAFRGQLGDVGALDTVWRELQD--AQEHDARGRSIAIARCYSLKNRHQDVMPYDS 1231

Query: 623  NEEMLCRDPKGKYGYVPRTALLPLETEVYDDVDFCDPLENQPLPL 667
            N  +L     GK  Y+  + +  L         +C PL     PL
Sbjct: 1232 NRVVL---RSGKDDYINASCVEGLS-------PYCPPLVATQAPL 1266



 Score = 38.1 bits (87), Expect = 0.026
 Identities = 21/54 (38%), Positives = 27/54 (50%), Gaps = 1/54 (1%)

Query: 67   VSLKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPS 120
            V+  P P E   LP    P E T +P   PPP  + LP+ P P E   +P+ PS
Sbjct: 1517 VASLPGPAEPPGLPPASLP-ESTPIPSSSPPPLSSPLPEAPQPKEEPPVPEAPS 1569



 Score = 36.6 bits (83), Expect = 0.077
 Identities = 20/51 (39%), Positives = 24/51 (47%), Gaps = 6/51 (11%)

Query: 74   PEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPSKLEL 124
            PE T +P   PPP  + LP+ P P E      +PP PE        S LEL
Sbjct: 1535 PESTPIPSSSPPPLSSPLPEAPQPKE------EPPVPEAPSSGPPSSSLEL 1579



 Score = 33.5 bits (75), Expect = 0.65
 Identities = 27/92 (29%), Positives = 34/92 (36%), Gaps = 30/92 (32%)

Query: 24   ASQPEPSDLPKKPPKPEFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPPPEVTDLPKKP 83
            AS P P++ P  PP                     A LPE   +    PPP  + LP+ P
Sbjct: 1518 ASLPGPAEPPGLPP---------------------ASLPESTPIPSSSPPPLSSPLPEAP 1556

Query: 84   PPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDL 115
             P E      +PP PE    P   PP    +L
Sbjct: 1557 QPKE------EPPVPEA---PSSGPPSSSLEL 1579



 Score = 33.1 bits (74), Expect = 0.85
 Identities = 35/129 (27%), Positives = 50/129 (38%), Gaps = 18/129 (13%)

Query: 349  ERRGPPRKFSQPEPSAVLKRHPQPEFFGDLPRKPPLPSSASESSLPAAVAGFSSRHPLSP 408
            +R G P        +++ +++  P+   DL     +P S    S+ A +A  S R P   
Sbjct: 1458 QRHGVPPPCKPLASASISQKNHLPQDSQDLVLGGDVPIS----SIQATIAKLSIRPPGGL 1513

Query: 409  GFGAAGTPRWRSGGLVHSGGARP-GLRPSHPPRRRPLPPASSLGHPPAKPPLPPGPVDMQ 467
                A  P          G A P GL P+  P   P+P +S    PP   PLP  P   +
Sbjct: 1514 ESPVASLP----------GPAEPPGLPPASLPESTPIPSSSP---PPLSSPLPEAPQPKE 1560

Query: 468  SFRRPSAAS 476
                P A S
Sbjct: 1561 EPPVPEAPS 1569



 Score = 32.3 bits (72), Expect = 1.5
 Identities = 42/157 (26%), Positives = 55/157 (35%), Gaps = 26/157 (16%)

Query: 27   PEPSDLPKKPPKPEFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPPPEVTDLPKKPPPP 86
            P PS  P +PP P        S   +   P+ APL   G  S     P    +P   P P
Sbjct: 1035 PFPSPGPPQPPHPPLAYGPAPSTRPMG--PQAAPLTIRGPSSAGQSTPSPHLVPSPAPSP 1092

Query: 87   EVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPSKLELSDLSKKFPQLGATPFPRKPLQP 146
                +P +PP  E       PPP     L +  +  +L   S +  Q G T  P      
Sbjct: 1093 GPGPVPPRPPAAE-------PPP----CLRRGAAAADLLSSSPE-SQHGGTQSPG----- 1135

Query: 147  EVGEAPLKASLPEPGAPARKP-----LQPDELSHPAR 178
              G  PL        A  R+P     ++ D   HP R
Sbjct: 1136 --GGQPLLQPTKVDAAEGRRPQALRLIERDPYEHPER 1170



 Score = 30.4 bits (67), Expect = 5.5
 Identities = 30/88 (34%), Positives = 39/88 (44%), Gaps = 16/88 (18%)

Query: 273  ASQPPLSDFPKKPPQ--PELGDLTRTSSEPEVSVLPKRPRPAEFKALSKKPPQPEL--GG 328
            AS P  ++ P  PP   PE   +  +S  P  S LP+ P+P E      +PP PE    G
Sbjct: 1518 ASLPGPAEPPGLPPASLPESTPIPSSSPPPLSSPLPEAPQPKE------EPPVPEAPSSG 1571

Query: 329  LPRTSSE------PEFNSLPRKLLQPER 350
             P +S E      PE  SL   L   +R
Sbjct: 1572 PPSSSLELLASLTPEAFSLDSSLRGKQR 1599


>gi|150417989 cyclin K isoform 1 [Homo sapiens]
          Length = 580

 Score = 76.6 bits (187), Expect = 7e-14
 Identities = 69/237 (29%), Positives = 87/237 (36%), Gaps = 22/237 (9%)

Query: 27  PEPSDLPKKPPKPEFGKLKKFSQPELSEHP---KKAPLPEFGAVSLKPPPPEVTDLPKKP 83
           P+  +   +PP P+  K++    P    HP   +K PL      +  P P + TDLPK  
Sbjct: 341 PKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQ 400

Query: 84  PPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPSKLELSDLSKKFPQLGATPFPRKP 143
            PP     P   PPP    LP +PPPP  +      S        + +  L +     K 
Sbjct: 401 IPPPAHPAPVHQPPP----LPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSM---MKT 453

Query: 144 LQPEVGEAPLKASLPEPGAPARKPLQPDEL-SHPARPPSEPKSGAFPRKLWQPEAGEATP 202
             P  G  P     P  G PA  P  P     +P  PP  P   +FP     P     TP
Sbjct: 454 EGPSYGALP-----PAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFP----PPAIPPPTP 504

Query: 203 RSPQPELSTFPK-KPAQPEFNVYPKKPPQPQVG-GLPKKSVPQPEFSEAAQTPLWKP 257
             P P  +  P   P  P        PP P  G GLP  S P P      Q P+  P
Sbjct: 505 GYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPP 561



 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 90/333 (27%), Positives = 114/333 (34%), Gaps = 78/333 (23%)

Query: 158 PEPGAPARKPLQPDELSHPARPPSEPKSGAFPRKLWQPEAGEATPRSPQPELSTFPKKPA 217
           P P  P  +  QP + S P++P  + K    P +  QP      P SPQP      K+  
Sbjct: 281 PTPQVPQVQQSQPSQSSEPSQP--QQKDPQQPAQQQQPAQQPKKP-SPQPSSPRQVKRAV 337

Query: 218 --QPEFNVYPKKPPQPQVGGLPKKSVPQPEFSEAAQTPLWKPQ------SSEPKR--DSS 267
              P+      +PP P++   PK     P    A   P  KP        +EP    D++
Sbjct: 338 VVSPKEENKAAEPPPPKI---PKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDAT 394

Query: 268 AFPKKASQPPLSDFPKKPPQPELGDLTRTSSEPEVSVLPKRPRPAEFKALSKKPPQPELG 327
             PK    PP    P   P P                LP RP P         PP   + 
Sbjct: 395 DLPKVQIPPPAHPAPVHQPPP----------------LPHRPPPP--------PPSSYMT 430

Query: 328 GLPRTSSEPE---FNSL--------PRKLLQPERRGPPRKFSQPEPSAVLKRHPQPEFFG 376
           G+  TSS      + SL        P     P   GPP     P    V   +P P    
Sbjct: 431 GMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHL--PYHPHVYPPNPPP---- 484

Query: 377 DLPRKPPLPSSASESSLPAAVAGFSSRHPL-SPGFGAAGTPRWRSGGLVHSGGARPGLRP 435
             P  PP P+S    ++P    G+    P  +P F     PR      V          P
Sbjct: 485 --PPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPP-PPRLPPTHAV----------P 531

Query: 436 SHPPRRRPLPPASSL-------GHPPAKPPLPP 461
            HPP    LPPAS         G PP  PP+PP
Sbjct: 532 PHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPP 564



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 49/163 (30%), Positives = 55/163 (33%), Gaps = 40/163 (24%)

Query: 35  KPPKPEFGKLKKFSQP--ELSEHPKKAPLPEFGAVSLKPPPPEVTDLPKKPPPPEVTDLP 92
           K   P +G L     P   L  HP   P          PPPP V   P   PPP +    
Sbjct: 452 KTEGPSYGALPPAYGPPAHLPYHPHVYPP--------NPPPPPVPPPPASFPPPAIPPPT 503

Query: 93  KKPPPPEVTDLPKKPPPPEVTDLPKKPSKLELSDLSKKFPQLGATPFPRKPLQPEVGEAP 152
              PPP  T  P  PPPP     P+ P            P     P P     P +G  P
Sbjct: 504 PGYPPPPPTYNPNFPPPP-----PRLP------------PTHAVPPHP----PPGLGLPP 542

Query: 153 LKASLPEPGAP--ARKPLQPDELSHPARPPSEPKSGAFPRKLW 193
             AS P P  P   + P+ P     P  PP  P  G   R  W
Sbjct: 543 --ASYPPPAVPPGGQPPVPP-----PIPPPGMPPVGGLGRAAW 578



 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 88/378 (23%), Positives = 119/378 (31%), Gaps = 131/378 (34%)

Query: 189 PRKLWQPEAGEATPRSPQ-----PELSTFPKKPAQPEFNVYPKKPPQPQVGGL-PKKSVP 242
           P +L QP + + TP+ PQ     P  S+ P +P Q +    P++P Q Q     PKK  P
Sbjct: 270 PHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKD----PQQPAQQQQPAQQPKKPSP 325

Query: 243 QPEFSEAAQTPLWKPQSSEPKRDSSAFPKKASQPPLSDFPK----KPPQPELGDLTRTSS 298
           QP      +  +       PK ++     KA++PP    PK     PP P          
Sbjct: 326 QPSSPRQVKRAV----VVSPKEEN-----KAAEPPPPKIPKIETTHPPLP---------- 366

Query: 299 EPEVSVLPKRPRPAEFKALSKKPPQPELGGLPRTSSEPEFNSLPRKLLQPERRGPPRKFS 358
                  P  P P       +KPP     G        +   LP+  + P     P    
Sbjct: 367 -------PAHPPP------DRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAH--PAPVH 411

Query: 359 QPEPSAVLKRHPQPEFFGDLPRKPPLPSSASESSLPAAVAGFSSRHPLSPGFGAAGTPRW 418
           QP P               LP +PP P  +S  +  +  + + S      G+ +  +   
Sbjct: 412 QPPP---------------LPHRPPPPPPSSYMTGMSTTSSYMS----GEGYQSLQSMMK 452

Query: 419 RSGGLVHSGGARPGLRPSHPPRRRPLPPASSLGHPPAKPPLPPGPVDMQSFRRPSAASID 478
             G    S GA P   P++ P      PA    HP   PP PP P               
Sbjct: 453 TEGP---SYGALP---PAYGP------PAHLPYHPHVYPPNPPPP--------------- 485

Query: 479 LRRTRSAAGLHFQDRQPEDIPVPDEIYELYDDVEPRDDSSPSPKGRDEAPSVQQAARRPP 538
                               PVP           P   S P P      P        PP
Sbjct: 486 --------------------PVP-----------PPPASFPPPAIPPPTPGY------PP 508

Query: 539 QDPALRKEKDPQPQQLPP 556
             P       P P +LPP
Sbjct: 509 PPPTYNPNFPPPPPRLPP 526



 Score = 36.6 bits (83), Expect = 0.077
 Identities = 32/134 (23%), Positives = 46/134 (34%), Gaps = 16/134 (11%)

Query: 435 PSHPPRRRPLPPASSLGHPPAKPPLPPGPVDMQSFRRPSAASIDLRRTRSAAGLHFQDRQ 494
           PS P ++ P  PA      PA+ P  P P      +   A  +  +    AA     +  
Sbjct: 299 PSQPQQKDPQQPAQQ--QQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAA-----EPP 351

Query: 495 PEDIPVPDEIYELYDDVEPRDDSSP---------SPKGRDEAPSVQQAARRPPQDPALRK 545
           P  IP  +  +       P  D  P          P G  +A  + +    PP  PA   
Sbjct: 352 PPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVH 411

Query: 546 EKDPQPQQLPPMDP 559
           +  P P + PP  P
Sbjct: 412 QPPPLPHRPPPPPP 425



 Score = 30.0 bits (66), Expect = 7.2
 Identities = 16/45 (35%), Positives = 23/45 (51%), Gaps = 3/45 (6%)

Query: 519 PSPKGRDEAPSVQQAARRPPQDPALRKEKDPQ---PQQLPPMDPK 560
           PS +   + P VQQ+      +P+  ++KDPQ    QQ P   PK
Sbjct: 277 PSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPK 321


>gi|239754327 PREDICTED: chromosome 6 open reading frame 132 [Homo
           sapiens]
          Length = 1188

 Score = 76.3 bits (186), Expect = 9e-14
 Identities = 147/576 (25%), Positives = 198/576 (34%), Gaps = 115/576 (19%)

Query: 32  LPKKPPKPEFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPPPEVTDLPKKPPPPEVTDL 91
           +P  PP P  G  +  S+P     P  +PLP     S  PPPP +  L + PPPP +   
Sbjct: 139 IPPPPPGPAPGPPQDISEP-----PGGSPLP--SPPSTAPPPPPL--LLEPPPPPSMA-- 187

Query: 92  PKKPP------PPEVTDLPKKPPPPEVTDLPKKPSKLELSDLSKKFPQLGATPFPRKP-- 143
           P  PP      PP     P  P PP+   +P  P    L+      P   A P P  P  
Sbjct: 188 PPPPPVLEALSPPHTLSSPSIPTPPDF--IPPAPPLAFLAPPPPPVP-APAPPAPASPHT 244

Query: 144 ----LQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARPPSEPKSGAFPRKLWQPEAGE 199
               L P  G    K+ +   G  A         + P R P+EPK             G 
Sbjct: 245 VGTRLFPPGGVTKWKSDVALNGRQAEA-----TRASPPRSPAEPK-------------GS 286

Query: 200 ATPRSPQPELSTFPKKPAQPEFNVYPKKPPQPQVGGLPKKSVPQPEFSEA---------- 249
           A   +P+P L TFP+    P        PP P    +   S+P  E  EA          
Sbjct: 287 ALGPNPEPHL-TFPRSFKVP--------PPTP----VRTSSIPVQEAQEAPRKEEGATKK 333

Query: 250 AQTPLWKPQSSEPKRDSSAFPKKASQPPLSDFPK--KPPQPELGDLTRTSSEPEVSVLPK 307
           A + L  P S   +  S  +P +A +P      K   P  P LG     + E   +  P 
Sbjct: 334 APSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPA 393

Query: 308 RPRPAEFKALSKKPPQPELGGLPRTSSEPEFNSLPRKLLQPERRGPPRKFSQPEPSAVLK 367
            P P         PP P L   P     P    LP      +   PP  F++   S+   
Sbjct: 394 PPLP---------PPAPPLPP-PAPPLPPAAPPLP---CAQKAAHPPAGFTKTPKSSSPA 440

Query: 368 RHPQPEFFGDLPRKPPLPSSASESSLPAAVAGFSSRHPLSPGFGA--AGTPRWRSGGLVH 425
             P+P         PP P + + SS P      S    L     A   G+ R     L H
Sbjct: 441 LKPKP--------NPPSPENTA-SSAPVDWRDPSQMEKLRNELAAYLCGSRR-EDRFLSH 490

Query: 426 SGGARPGLRPSHPPRRRPLPPASSLGHPPAKPPLPPGPVDMQSFRRPSAASIDLRRTRSA 485
             G     +     +   LP   +L   PAK   PPG  +       S     L  T +A
Sbjct: 491 RPGPTVAPQSKEGKKGPRLPEKETLLSLPAK-DTPPGVPE------KSLGGSSLTETEAA 543

Query: 486 AGLHFQ--DRQPEDIPVPDEIYELYDDVEPRDDSSPSPKGRDEAPSVQQAAR-------- 535
             L     D  P+D P P  + ++ +++E R  S+   + +    S+    R        
Sbjct: 544 PSLTLPSVDYIPQDSPTP-SVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICE 602

Query: 536 RPPQDPALRKEKDPQPQQLPPMDPKLLKQLRKAEKA 571
               D  L K   P  + LPP    LL       KA
Sbjct: 603 NGADDDKLSK---PVAKNLPPQSTTLLPTTSLQPKA 635



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 132/569 (23%), Positives = 186/569 (32%), Gaps = 150/569 (26%)

Query: 27   PEPSDLPKKPPKPEFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPPPEVT--------- 77
            P    +P+  P P   +++   +  LS   +K   P  G++   PP P +          
Sbjct: 549  PSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSL---PPKPRLEGGRICENGA 605

Query: 78   --DLPKKP-----PPPEVTDLPKKPPPPEVTDLPKKPP--------PPEVTDLPKKPSKL 122
              D   KP     PP   T LP     P+    P  PP        PP+ T  P  P K 
Sbjct: 606  DDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPATPPKA 665

Query: 123  ELSDLSKKFPQLGATPFPRKPLQPEVGEAPLKASLPEP-----------GAPARKPLQP- 170
             L   +     L AT  P  PL+   G A    +   P             PA +P +P 
Sbjct: 666  TLGPATP----LKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPA 721

Query: 171  -DELSHPARP-----PSEP---------KSGAFPRK----------LWQPEA-------- 197
              E+S P++      PSE           S AFP K          L++P          
Sbjct: 722  SQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSRE 781

Query: 198  -----------GEATPRSPQPELSTFPKKPAQPEFNVYPKKP--PQPQVGGLPKKSVPQP 244
                       G A P  P  E+   P  PA+P  +  P       P  G + ++  P  
Sbjct: 782  VAVVMPTLARGGAAGPGEPV-EVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERGSPMA 840

Query: 245  EFSEAAQTPLWKPQSSEPKRDSSAFPKKASQPPLSDFPKKPPQPELGDLTRTSSEPEVSV 304
                A Q      ++ + +   +A  + +    L D   +             +    +V
Sbjct: 841  LLLAARQ------RAQKGRSVGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTV 894

Query: 305  LPKRPRPAEFKALSKKPPQPELGGLPRTSSEPEFNSLPRK--LLQPERRGP--------- 353
            +PK P+ AE K        P   G PR   + E   L R+    +PE + P         
Sbjct: 895  VPKLPKEAE-KDSPLTTEIPNKWG-PRLGRDAEGTELSRRHNWTKPEPQAPVAWERVAPS 952

Query: 354  --------PRKFSQPEPSAVLKRHPQPEFFGDLPRKPPLPSSASESSLPAAVAGFSSRHP 405
                    P+ FS P PS   KR  + E F +    PP P  +++   PA    +  R  
Sbjct: 953  NLPQGHPLPKSFSSP-PSPSNKREEEEEEF-NFEVIPPPPEFSNDPEPPAPALQYLGRQS 1010

Query: 406  LSP-------------GFGA----------AGTPRWRSGGLVH-SGGARPGLRP----SH 437
              P             G GA          AG     +GGL   SGG R  ++       
Sbjct: 1011 SPPRNNYSDLRQLPNAGPGAPPALGFSRFPAGARYAGAGGLERFSGGGRSLIKKRLYVGE 1070

Query: 438  PPRRRPLP---PASSLGHPPAKPPLPPGP 463
            P R   LP      SL  P    P P GP
Sbjct: 1071 PHRGPGLPHGGTGRSLSSPNCFGPQPGGP 1099


>gi|239748855 PREDICTED: chromosome 6 open reading frame 132 [Homo
           sapiens]
          Length = 1188

 Score = 76.3 bits (186), Expect = 9e-14
 Identities = 147/576 (25%), Positives = 198/576 (34%), Gaps = 115/576 (19%)

Query: 32  LPKKPPKPEFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPPPEVTDLPKKPPPPEVTDL 91
           +P  PP P  G  +  S+P     P  +PLP     S  PPPP +  L + PPPP +   
Sbjct: 139 IPPPPPGPAPGPPQDISEP-----PGGSPLP--SPPSTAPPPPPL--LLEPPPPPSMA-- 187

Query: 92  PKKPP------PPEVTDLPKKPPPPEVTDLPKKPSKLELSDLSKKFPQLGATPFPRKP-- 143
           P  PP      PP     P  P PP+   +P  P    L+      P   A P P  P  
Sbjct: 188 PPPPPVLEALSPPHTLSSPSIPTPPDF--IPPAPPLAFLAPPPPPVP-APAPPAPASPHT 244

Query: 144 ----LQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARPPSEPKSGAFPRKLWQPEAGE 199
               L P  G    K+ +   G  A         + P R P+EPK             G 
Sbjct: 245 VGTRLFPPGGVTKWKSDVALNGRQAEA-----TRASPPRSPAEPK-------------GS 286

Query: 200 ATPRSPQPELSTFPKKPAQPEFNVYPKKPPQPQVGGLPKKSVPQPEFSEA---------- 249
           A   +P+P L TFP+    P        PP P    +   S+P  E  EA          
Sbjct: 287 ALGPNPEPHL-TFPRSFKVP--------PPTP----VRTSSIPVQEAQEAPRKEEGATKK 333

Query: 250 AQTPLWKPQSSEPKRDSSAFPKKASQPPLSDFPK--KPPQPELGDLTRTSSEPEVSVLPK 307
           A + L  P S   +  S  +P +A +P      K   P  P LG     + E   +  P 
Sbjct: 334 APSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPA 393

Query: 308 RPRPAEFKALSKKPPQPELGGLPRTSSEPEFNSLPRKLLQPERRGPPRKFSQPEPSAVLK 367
            P P         PP P L   P     P    LP      +   PP  F++   S+   
Sbjct: 394 PPLP---------PPAPPLPP-PAPPLPPAAPPLP---CAQKAAHPPAGFTKTPKSSSPA 440

Query: 368 RHPQPEFFGDLPRKPPLPSSASESSLPAAVAGFSSRHPLSPGFGA--AGTPRWRSGGLVH 425
             P+P         PP P + + SS P      S    L     A   G+ R     L H
Sbjct: 441 LKPKP--------NPPSPENTA-SSAPVDWRDPSQMEKLRNELAAYLCGSRR-EDRFLSH 490

Query: 426 SGGARPGLRPSHPPRRRPLPPASSLGHPPAKPPLPPGPVDMQSFRRPSAASIDLRRTRSA 485
             G     +     +   LP   +L   PAK   PPG  +       S     L  T +A
Sbjct: 491 RPGPTVAPQSKEGKKGPRLPEKETLLSLPAK-DTPPGVPE------KSLGGSSLTETEAA 543

Query: 486 AGLHFQ--DRQPEDIPVPDEIYELYDDVEPRDDSSPSPKGRDEAPSVQQAAR-------- 535
             L     D  P+D P P  + ++ +++E R  S+   + +    S+    R        
Sbjct: 544 PSLTLPSVDYIPQDSPTP-SVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICE 602

Query: 536 RPPQDPALRKEKDPQPQQLPPMDPKLLKQLRKAEKA 571
               D  L K   P  + LPP    LL       KA
Sbjct: 603 NGADDDKLSK---PVAKNLPPQSTTLLPTTSLQPKA 635



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 132/569 (23%), Positives = 186/569 (32%), Gaps = 150/569 (26%)

Query: 27   PEPSDLPKKPPKPEFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPPPEVT--------- 77
            P    +P+  P P   +++   +  LS   +K   P  G++   PP P +          
Sbjct: 549  PSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSL---PPKPRLEGGRICENGA 605

Query: 78   --DLPKKP-----PPPEVTDLPKKPPPPEVTDLPKKPP--------PPEVTDLPKKPSKL 122
              D   KP     PP   T LP     P+    P  PP        PP+ T  P  P K 
Sbjct: 606  DDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPATPPKA 665

Query: 123  ELSDLSKKFPQLGATPFPRKPLQPEVGEAPLKASLPEP-----------GAPARKPLQP- 170
             L   +     L AT  P  PL+   G A    +   P             PA +P +P 
Sbjct: 666  TLGPATP----LKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPA 721

Query: 171  -DELSHPARP-----PSEP---------KSGAFPRK----------LWQPEA-------- 197
              E+S P++      PSE           S AFP K          L++P          
Sbjct: 722  SQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSRE 781

Query: 198  -----------GEATPRSPQPELSTFPKKPAQPEFNVYPKKP--PQPQVGGLPKKSVPQP 244
                       G A P  P  E+   P  PA+P  +  P       P  G + ++  P  
Sbjct: 782  VAVVMPTLARGGAAGPGEPV-EVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERGSPMA 840

Query: 245  EFSEAAQTPLWKPQSSEPKRDSSAFPKKASQPPLSDFPKKPPQPELGDLTRTSSEPEVSV 304
                A Q      ++ + +   +A  + +    L D   +             +    +V
Sbjct: 841  LLLAARQ------RAQKGRSVGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTV 894

Query: 305  LPKRPRPAEFKALSKKPPQPELGGLPRTSSEPEFNSLPRK--LLQPERRGP--------- 353
            +PK P+ AE K        P   G PR   + E   L R+    +PE + P         
Sbjct: 895  VPKLPKEAE-KDSPLTTEIPNKWG-PRLGRDAEGTELSRRHNWTKPEPQAPVAWERVAPS 952

Query: 354  --------PRKFSQPEPSAVLKRHPQPEFFGDLPRKPPLPSSASESSLPAAVAGFSSRHP 405
                    P+ FS P PS   KR  + E F +    PP P  +++   PA    +  R  
Sbjct: 953  NLPQGHPLPKSFSSP-PSPSNKREEEEEEF-NFEVIPPPPEFSNDPEPPAPALQYLGRQS 1010

Query: 406  LSP-------------GFGA----------AGTPRWRSGGLVH-SGGARPGLRP----SH 437
              P             G GA          AG     +GGL   SGG R  ++       
Sbjct: 1011 SPPRNNYSDLRQLPNAGPGAPPALGFSRFPAGARYAGAGGLERFSGGGRSLIKKRLYVGE 1070

Query: 438  PPRRRPLP---PASSLGHPPAKPPLPPGP 463
            P R   LP      SL  P    P P GP
Sbjct: 1071 PHRGPGLPHGGTGRSLSSPNCFGPQPGGP 1099


>gi|239742884 PREDICTED: hypothetical protein LOC647024 [Homo
           sapiens]
          Length = 1188

 Score = 76.3 bits (186), Expect = 9e-14
 Identities = 147/576 (25%), Positives = 198/576 (34%), Gaps = 115/576 (19%)

Query: 32  LPKKPPKPEFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPPPEVTDLPKKPPPPEVTDL 91
           +P  PP P  G  +  S+P     P  +PLP     S  PPPP +  L + PPPP +   
Sbjct: 139 IPPPPPGPAPGPPQDISEP-----PGGSPLP--SPPSTAPPPPPL--LLEPPPPPSMA-- 187

Query: 92  PKKPP------PPEVTDLPKKPPPPEVTDLPKKPSKLELSDLSKKFPQLGATPFPRKP-- 143
           P  PP      PP     P  P PP+   +P  P    L+      P   A P P  P  
Sbjct: 188 PPPPPVLEALSPPHTLSSPSIPTPPDF--IPPAPPLAFLAPPPPPVP-APAPPAPASPHT 244

Query: 144 ----LQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARPPSEPKSGAFPRKLWQPEAGE 199
               L P  G    K+ +   G  A         + P R P+EPK             G 
Sbjct: 245 VGTRLFPPGGVTKWKSDVALNGRQAEA-----TRASPPRSPAEPK-------------GS 286

Query: 200 ATPRSPQPELSTFPKKPAQPEFNVYPKKPPQPQVGGLPKKSVPQPEFSEA---------- 249
           A   +P+P L TFP+    P        PP P    +   S+P  E  EA          
Sbjct: 287 ALGPNPEPHL-TFPRSFKVP--------PPTP----VRTSSIPVQEAQEAPRKEEGATKK 333

Query: 250 AQTPLWKPQSSEPKRDSSAFPKKASQPPLSDFPK--KPPQPELGDLTRTSSEPEVSVLPK 307
           A + L  P S   +  S  +P +A +P      K   P  P LG     + E   +  P 
Sbjct: 334 APSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPA 393

Query: 308 RPRPAEFKALSKKPPQPELGGLPRTSSEPEFNSLPRKLLQPERRGPPRKFSQPEPSAVLK 367
            P P         PP P L   P     P    LP      +   PP  F++   S+   
Sbjct: 394 PPLP---------PPAPPLPP-PAPPLPPAAPPLP---CAQKAAHPPAGFTKTPKSSSPA 440

Query: 368 RHPQPEFFGDLPRKPPLPSSASESSLPAAVAGFSSRHPLSPGFGA--AGTPRWRSGGLVH 425
             P+P         PP P + + SS P      S    L     A   G+ R     L H
Sbjct: 441 LKPKP--------NPPSPENTA-SSAPVDWRDPSQMEKLRNELAAYLCGSRR-EDRFLSH 490

Query: 426 SGGARPGLRPSHPPRRRPLPPASSLGHPPAKPPLPPGPVDMQSFRRPSAASIDLRRTRSA 485
             G     +     +   LP   +L   PAK   PPG  +       S     L  T +A
Sbjct: 491 RPGPTVAPQSKEGKKGPRLPEKETLLSLPAK-DTPPGVPE------KSLGGSSLTETEAA 543

Query: 486 AGLHFQ--DRQPEDIPVPDEIYELYDDVEPRDDSSPSPKGRDEAPSVQQAAR-------- 535
             L     D  P+D P P  + ++ +++E R  S+   + +    S+    R        
Sbjct: 544 PSLTLPSVDYIPQDSPTP-SVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICE 602

Query: 536 RPPQDPALRKEKDPQPQQLPPMDPKLLKQLRKAEKA 571
               D  L K   P  + LPP    LL       KA
Sbjct: 603 NGADDDKLSK---PVAKNLPPQSTTLLPTTSLQPKA 635



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 132/569 (23%), Positives = 186/569 (32%), Gaps = 150/569 (26%)

Query: 27   PEPSDLPKKPPKPEFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPPPEVT--------- 77
            P    +P+  P P   +++   +  LS   +K   P  G++   PP P +          
Sbjct: 549  PSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSL---PPKPRLEGGRICENGA 605

Query: 78   --DLPKKP-----PPPEVTDLPKKPPPPEVTDLPKKPP--------PPEVTDLPKKPSKL 122
              D   KP     PP   T LP     P+    P  PP        PP+ T  P  P K 
Sbjct: 606  DDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPATPPKA 665

Query: 123  ELSDLSKKFPQLGATPFPRKPLQPEVGEAPLKASLPEP-----------GAPARKPLQP- 170
             L   +     L AT  P  PL+   G A    +   P             PA +P +P 
Sbjct: 666  TLGPATP----LKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPA 721

Query: 171  -DELSHPARP-----PSEP---------KSGAFPRK----------LWQPEA-------- 197
              E+S P++      PSE           S AFP K          L++P          
Sbjct: 722  SQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSRE 781

Query: 198  -----------GEATPRSPQPELSTFPKKPAQPEFNVYPKKP--PQPQVGGLPKKSVPQP 244
                       G A P  P  E+   P  PA+P  +  P       P  G + ++  P  
Sbjct: 782  VAVVMPTLARGGAAGPGEPV-EVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERGSPMA 840

Query: 245  EFSEAAQTPLWKPQSSEPKRDSSAFPKKASQPPLSDFPKKPPQPELGDLTRTSSEPEVSV 304
                A Q      ++ + +   +A  + +    L D   +             +    +V
Sbjct: 841  LLLAARQ------RAQKGRSVGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTV 894

Query: 305  LPKRPRPAEFKALSKKPPQPELGGLPRTSSEPEFNSLPRK--LLQPERRGP--------- 353
            +PK P+ AE K        P   G PR   + E   L R+    +PE + P         
Sbjct: 895  VPKLPKEAE-KDSPLTTEIPNKWG-PRLGRDAEGTELSRRHNWTKPEPQAPVAWERVAPS 952

Query: 354  --------PRKFSQPEPSAVLKRHPQPEFFGDLPRKPPLPSSASESSLPAAVAGFSSRHP 405
                    P+ FS P PS   KR  + E F +    PP P  +++   PA    +  R  
Sbjct: 953  NLPQGHPLPKSFSSP-PSPSNKREEEEEEF-NFEVIPPPPEFSNDPEPPAPALQYLGRQS 1010

Query: 406  LSP-------------GFGA----------AGTPRWRSGGLVH-SGGARPGLRP----SH 437
              P             G GA          AG     +GGL   SGG R  ++       
Sbjct: 1011 SPPRNNYSDLRQLPNAGPGAPPALGFSRFPAGARYAGAGGLERFSGGGRSLIKKRLYVGE 1070

Query: 438  PPRRRPLP---PASSLGHPPAKPPLPPGP 463
            P R   LP      SL  P    P P GP
Sbjct: 1071 PHRGPGLPHGGTGRSLSSPNCFGPQPGGP 1099


>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
          Length = 1020

 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 119/577 (20%), Positives = 206/577 (35%), Gaps = 95/577 (16%)

Query: 28  EPSDLPKKPPKPEFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPPPEVTDLPKKPPPPE 87
           E ++  +K  K E GK ++  + E +E          G    K PP E    P+K     
Sbjct: 469 EVTEEEEKEAKEEEGKEEEGGEEEEAEG---------GEEETKSPPAEEAASPEKEAKSP 519

Query: 88  VTDLPKKPPPPEVTDLPKKPPPPEV--TDLPKKPSKLEL-SDLSKKFPQLGATPFPRKPL 144
           V +  K P   +  +  +   P EV   +  K P+K E  S    K P+      P +  
Sbjct: 520 VKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVK 579

Query: 145 QPEVGEAPLKASLPEPG-----APARKPLQ-----PDELSHP----ARPPSEPKSGAFPR 190
            PE  ++P K     P        A+ P++     P E   P    A+ P+E KS   P 
Sbjct: 580 SPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKS---PE 636

Query: 191 KLWQPEAGEA----TPRSPQPELSTFPKKPAQPEFNVYPKKPPQPQVGGLPKKSVPQPEF 246
           K   P   EA      +SP+ E +  P+K   P       +   P+    P K+  + + 
Sbjct: 637 KAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSP----VKAEAKSPEKAKSPVKA--EAKS 690

Query: 247 SEAAQTPLWKPQSSEPKRDSSAFPKKASQPPLSDFP----KKPPQPELGDLTRTSSEPEV 302
            E A++P+ K ++  P++  S   ++A  P  +  P     K P+     +   +  PE 
Sbjct: 691 PEKAKSPV-KEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEK 749

Query: 303 SVLPKRPRPAEFKALSKKPPQPELGGLPRTS-SEPEFNSLPRKLLQPERRGPPRKFSQPE 361
           +  P++ +  + K+   K P  E    P     E   + +  ++  PE+   P K     
Sbjct: 750 AKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKA 809

Query: 362 PSAVLKRHPQPEFFGDLPRKPPLPSSASESSLPAAVAGFSSRHPLSPGFGAAGTPRWRSG 421
           P              ++P+K  + S   E   P  V         +    A  TP+    
Sbjct: 810 PEK------------EIPKKEEVKSPVKEEEKPQEVK-VKEPPKKAEEEKAPATPKTEE- 855

Query: 422 GLVHSGGARPGLRPSHPPRRRPLPPASSLGHPPAKPPLPPGPVDMQSFRRPSAASIDLRR 481
                   +   +   P +  P P       P              +  +P  + ++ ++
Sbjct: 856 -------KKDSKKEEAPKKEAPKPKVEEKKEP--------------AVEKPKESKVEAKK 894

Query: 482 TRSAAGLHFQDRQPEDIPVPDEIYELYDDVEPRDDSSPSPKGRDEAPSVQQAARRPPQDP 541
             +           + +P P++  E    VE ++D+ P  K          A  + P  P
Sbjct: 895 EEA--------EDKKKVPTPEK--EAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKP 944

Query: 542 ALRKEKDPQPQQLPPMDPKLLKQLRKAEKAEREFRKK 578
           A +KE  P+ +     D K  K  +  EK + E + K
Sbjct: 945 AEKKEAAPEKK-----DTKEEKAKKPEEKPKTEAKAK 976



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 89/351 (25%), Positives = 148/351 (42%), Gaps = 43/351 (12%)

Query: 21   KFQASQPEPSDLP-----KKPPKPEFGKLKKFSQPELSEHPKK--APLPEFGAVSLKPPP 73
            K +A  PE +  P     K P K +    ++   PE ++ P K  A  PE      K P 
Sbjct: 671  KAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPE----KAKSPV 726

Query: 74   PEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEV-TDLPKKPSKLELSDLSKKFP 132
             E    P+K   P    + ++   PE    P+K    +V +   K P+K E    + KFP
Sbjct: 727  KEEAKTPEKAKSP----VKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFP 782

Query: 133  QLGATPFPRKPLQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARPPSEPKSGAF--PR 190
            +   +P   +   PE  ++PLK    +  AP ++  + +E+  P +   +P+      P 
Sbjct: 783  EKAKSPVKEEVKSPEKAKSPLK---EDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPP 839

Query: 191  KLWQPEAGEATPRSPQPELS---TFPKKPAQPEFNVYPKKPP---QPQVGGL-------- 236
            K  + E   ATP++ + + S     PKK A P+  V  KK P   +P+   +        
Sbjct: 840  KKAEEEKAPATPKTEEKKDSKKEEAPKKEA-PKPKVEEKKEPAVEKPKESKVEAKKEEAE 898

Query: 237  PKKSVPQPEFSEAAQTPLWKPQSSEPKRDSSAFPKK----ASQPPLSDFPKKPPQPELGD 292
             KK VP PE    A+  +   + ++PK  +    K+     ++ P     KK   PE  D
Sbjct: 899  DKKKVPTPEKEAPAKVEV--KEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKD 956

Query: 293  L-TRTSSEPEVSVLPKRPRPAEFKALSKKPPQPELGGLPRTSSEPEFNSLP 342
                 + +PE     +     + K LSK+P +P+     ++SS  + +S P
Sbjct: 957  TKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKP 1007



 Score = 63.5 bits (153), Expect = 6e-10
 Identities = 91/399 (22%), Positives = 148/399 (37%), Gaps = 50/399 (12%)

Query: 6   PAAMESHQDFRSIKAKFQASQPEPSDLPKKPPKPEFGKLKKFSQPELSEHPKKAPLPEFG 65
           P A E+    +  K+  +     P++  K P K E     +   PE ++ P K       
Sbjct: 504 PPAEEAASPEKEAKSPVKEEAKSPAEA-KSPEKEEAKSPAEVKSPEKAKSPAKEE----- 557

Query: 66  AVSLKPPPPEVTDLPKKPPPPEVTDLPK-KPPPPEVTDLPKKPPPPEVTDLP-------- 116
             +  PP  +  +  +   P EV    K K P  E    P +   PE    P        
Sbjct: 558 --AKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSP 615

Query: 117 ---KKPSKLEL-SDLSKKFPQLGATPFPRKPLQPEVGEAPLKASLPEPGAPARKPLQ--- 169
              K P K E  S    K P+   +P   +   PE  ++P K     P   A+ P++   
Sbjct: 616 AEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSP-EKAKSPVKAEA 674

Query: 170 --PDELSHP----ARPPSEPKS-----GAFPRKLWQPEAGEATPRSPQPELSTFPKKPAQ 218
             P++   P    A+ P + KS        P K   P   EA  +SP+   S   ++   
Sbjct: 675 KSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEA--KSPEKAKSPVKEEAKT 732

Query: 219 PEFNVYPKK--PPQPQVGGLPKKSVPQPEFSEAAQTPLWKPQSSEPKRDSSAFPKKASQP 276
           PE    P K     P+    P+K+      S  A+T    P   E +  +  FP+KA  P
Sbjct: 733 PEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKT----PAKEEARSPADKFPEKAKSP 788

Query: 277 PLSDFPKKPPQPELGDLTRTSSEPEVSVLPKRPRPAEFKALSKKPPQPELGGLPRTSSEP 336
              +   K P+     L   +  PE  + PK+          +KP + ++   P+ + E 
Sbjct: 789 VKEEV--KSPEKAKSPLKEDAKAPEKEI-PKKEEVKSPVKEEEKPQEVKVKEPPKKAEEE 845

Query: 337 EFNSLPR--KLLQPERRGPPRKFSQPEPSAVLKRHPQPE 373
           +  + P+  +    ++   P+K   P+P    K+ P  E
Sbjct: 846 KAPATPKTEEKKDSKKEEAPKK-EAPKPKVEEKKEPAVE 883



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 96/450 (21%), Positives = 166/450 (36%), Gaps = 50/450 (11%)

Query: 174 SHPARPPSEPKSGAFPRKLWQPEAGEATPRSPQPELSTFPKKPAQPEFNVYPKKPPQPQV 233
           S PA   + P+  A    + +     A  +SP+ E +  P +   PE     K P + + 
Sbjct: 503 SPPAEEAASPEKEA-KSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPE---KAKSPAKEEA 558

Query: 234 GGLPKKSVPQPEFSEAAQTPLWKPQSSEPKRDSSAFPKKASQPPLSDFPKKPPQPELGDL 293
              P+   P+    E A++P    +   P++  S   ++A  P  +  P+K   P + + 
Sbjct: 559 KSPPEAKSPE---KEEAKSP---AEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSP-VKEE 611

Query: 294 TRTSSEPEVSVLPKRPRPAEFKALSK-KPPQPELGGLPRTSSEPEFNSLPRKLLQPERRG 352
            ++ +E +  V  +   PAE K+  K K P  E    P  +  PE      +   PE+  
Sbjct: 612 AKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPE----KEEAKSPEKAK 667

Query: 353 PPRKFSQPEPSAVLKRHPQPEFFGDLPRKPPLPSSA---SESSLPAAVAGFSSRHPLSPG 409
            P K     P    K   + E       K P+   A    ++  P      S     SP 
Sbjct: 668 SPVKAEAKSPEKA-KSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPV 726

Query: 410 FGAAGTPRWRSGGLVHSGGARPGLRPSHPPRRRPLPPASSLGHPPAK----------PPL 459
              A TP      +     A+   +   P + + L   S     PAK          P  
Sbjct: 727 KEEAKTPEKAKSPVKEE--AKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEK 784

Query: 460 PPGPVDMQSFRRPSAASIDLRRTRSAAGLHFQDRQPEDIPV-----PDEIYELYDDVEPR 514
              PV  +  + P  A   L+    A       ++    PV     P E+       +  
Sbjct: 785 AKSPV-KEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAE 843

Query: 515 DDSSP-SPKGRDEAPS-VQQAARRPPQDPALRKEKDPQPQQLPPMDPKLLKQLRKAEKAE 572
           ++ +P +PK  ++  S  ++A ++    P + ++K+P  ++  P + K+     +A+K E
Sbjct: 844 EEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEK--PKESKV-----EAKKEE 896

Query: 573 REFRKKF---KFEGEIVVHTKMMIDPNAKT 599
            E +KK    + E    V  K    P  KT
Sbjct: 897 AEDKKKVPTPEKEAPAKVEVKEDAKPKEKT 926



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 64/275 (23%), Positives = 99/275 (36%), Gaps = 36/275 (13%)

Query: 7    AAMESHQDFRSIKAKFQASQPEPSDLPKKPPKPEFGKLKKFSQPELSEHPKKAPLPEFGA 66
            A   + ++ RS   KF      P     K P+     LK+ ++    E PKK  +     
Sbjct: 766  AKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVK 825

Query: 67   VSLKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPSKLELSD 126
               KP   +V + PKK    E    P  P   E  D  K+  P +    PK   K E   
Sbjct: 826  EEEKPQEVKVKEPPKK---AEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKE--- 879

Query: 127  LSKKFPQLGATPFPRKPLQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARPPSEPKSG 186
                 P +      +   + E  E   K   PE  APA+  ++ D         ++PK  
Sbjct: 880  -----PAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKED---------AKPK-- 923

Query: 187  AFPRKLWQPEAGEATPRSPQPELSTFPKKPAQPEFNVYPKKPPQPQVGGLPKKSVPQPEF 246
                     E  E   + P    +  P KPA+ +     KK  + +    P++  P+ E 
Sbjct: 924  ---------EKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEK-PKTEA 973

Query: 247  SEAAQTPLWKPQSSEPKRD----SSAFPKKASQPP 277
                       + S+PK +    SS+  +K S+PP
Sbjct: 974  KAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPP 1008



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 86/405 (21%), Positives = 137/405 (33%), Gaps = 60/405 (14%)

Query: 227 KPPQPQVGGLPKKSVPQPEFSEAAQTPLWK-PQSSEPKRDSSAFPKKASQPPLSDFPKKP 285
           K P  +    P+K    P   EA      K P+  E K  +     + ++ P  +  K P
Sbjct: 502 KSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSP 561

Query: 286 PQPELGDLTRTSSEPEVSVLPKRPRPAEFKALS---------KKPPQPELGGLPRTSSEP 336
           P+ +  +     S  EV    K   PA+ +A S          K P  E    P  +  P
Sbjct: 562 PEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSP 621

Query: 337 --EFNSLPRKLLQPERRGPPRKFSQPEPSAVLKRHPQPEFFGDLPRKPPLP-----SSAS 389
             E    P ++  PE+   P K     P     + P+ E     P K   P      S  
Sbjct: 622 VKEEAKSPAEVKSPEKAKSPTKEEAKSPEKA--KSPEKE-EAKSPEKAKSPVKAEAKSPE 678

Query: 390 ESSLPAAVAGFSSRHPLSPGFGAAGTPRWRSGGLVHSG-----GARPGLRPSHPPRRRPL 444
           ++  P      S     SP    A +P      +            P    +  P +   
Sbjct: 679 KAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKS 738

Query: 445 PPASSLGHP-PAKPPLPPGPVDMQSFRRPSAASIDLRRTRSAAGLHFQDRQPEDI--PVP 501
           P       P  AK P     +D++S   P A +      RS A     D+ PE    PV 
Sbjct: 739 PVKEEAKSPEKAKSPEKAKTLDVKS---PEAKTPAKEEARSPA-----DKFPEKAKSPVK 790

Query: 502 DEIYE-------LYDDVE------PRDDSSPSPKGRDEAPSVQQAARRP--------PQD 540
           +E+         L +D +      P+ +   SP   +E P   +    P        P  
Sbjct: 791 EEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPAT 850

Query: 541 PALRKEKDPQPQQLPPMD---PKLLKQLRKAEKAEREFRKKFKFE 582
           P   ++KD + ++ P  +   PK+ ++   A +  +E + + K E
Sbjct: 851 PKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKE 895



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 64/349 (18%), Positives = 120/349 (34%), Gaps = 15/349 (4%)

Query: 243 QPEFSEAAQTPLWKPQSSEPKRDSSAFPKKASQPPLSDFPKKPPQPELGDLTRTSSEPEV 302
           + E  E  +    + ++  P  + +A P+K ++ P+ +  K P + +  +     S  EV
Sbjct: 485 EEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEV 544

Query: 303 SVLPKRPRPAEFKALS---KKPPQPELGGLPRTSSEPEFNSLPRK--LLQPERRGPPRKF 357
               K   PA+ +A S    K P+ E    P     PE    P K     P     P K 
Sbjct: 545 KSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKA 604

Query: 358 SQPEPSAVLKRHPQPEFFGDLPRKPPLPSSASESSLPAAVAGFSSRHPLSPGFGAAGTP- 416
             P                +  + P    S  ++  P      S     SP    A +P 
Sbjct: 605 KSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPE 664

Query: 417 RWRSGGLVHSGGARPGLRPSHPPRRRPLPPASSLGHPPAKPPLPPGPVDMQSFRRPSAAS 476
           + +S     +        P     + P    S +      P     PV  ++ + P  A 
Sbjct: 665 KAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEA-KSPEKAK 723

Query: 477 IDLRR-----TRSAAGLHFQDRQPEDIPVPDEIYELYDDVEPRDDSSPSPKGRDEAPSVQ 531
             ++       ++ + +  + + PE    P++   L D   P   +    + R  A    
Sbjct: 724 SPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTL-DVKSPEAKTPAKEEARSPADKFP 782

Query: 532 QAARRPPQDPALRKEKDPQPQQLPPMDPKLLKQLRKAEKAEREFRKKFK 580
           + A+ P ++     EK   P +     P+  K++ K E+ +   +++ K
Sbjct: 783 EKAKSPVKEEVKSPEKAKSPLKEDAKAPE--KEIPKKEEVKSPVKEEEK 829


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.311    0.134    0.409 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,951,067
Number of Sequences: 37866
Number of extensions: 3134960
Number of successful extensions: 38562
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 435
Number of HSP's successfully gapped in prelim test: 1761
Number of HSP's that attempted gapping in prelim test: 14856
Number of HSP's gapped (non-prelim): 11924
length of query: 669
length of database: 18,247,518
effective HSP length: 109
effective length of query: 560
effective length of database: 14,120,124
effective search space: 7907269440
effective search space used: 7907269440
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.