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Search of human proteins with 40548322
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|40548322 Rho GTPase activating protein 27 isoform a [Homo
sapiens]
(548 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|40548322 Rho GTPase activating protein 27 isoform a [Homo sap... 1120 0.0
gi|226693398 Rho GTPase activating protein 27 isoform b [Homo sa... 1043 0.0
gi|26986534 Rho GTPase activating protein 12 [Homo sapiens] 422 e-118
gi|188497642 ARHGAP15 [Homo sapiens] 356 3e-98
gi|122939147 Rho GTPase activating protein 9 isoform 1 [Homo sap... 317 2e-86
gi|122939149 Rho GTPase activating protein 9 isoform 3 [Homo sap... 317 2e-86
gi|122939151 Rho GTPase activating protein 9 isoform 2 [Homo sap... 236 3e-62
gi|224458284 Rho GTPase activating protein 23 [Homo sapiens] 146 5e-35
gi|23510413 sorting nexin 26 [Homo sapiens] 141 1e-33
gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens] 139 9e-33
gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens] 139 9e-33
gi|203097003 Rho GTPase activating protein 21 [Homo sapiens] 139 9e-33
gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens] 138 1e-32
gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens] 138 1e-32
gi|229094128 active breakpoint cluster region-related protein i... 137 2e-32
gi|38679957 active breakpoint cluster region-related protein is... 137 2e-32
gi|38679954 active breakpoint cluster region-related protein is... 137 2e-32
gi|150417981 glucocorticoid receptor DNA binding factor 1 [Homo ... 136 6e-32
gi|4757980 beta chimerin isoform 2 [Homo sapiens] 132 1e-30
gi|91106928 beta chimerin isoform 1 [Homo sapiens] 132 1e-30
gi|218083800 Rho GTPase-activating protein isoform 1 [Homo sapiens] 132 1e-30
gi|29469071 Rho GTPase-activating protein isoform 2 [Homo sapiens] 126 4e-29
gi|221307575 Rho-type GTPase-activating protein FLJ32810 [Homo s... 125 8e-29
gi|71040096 Rho GTPase activating protein 30 isoform 2 [Homo sap... 123 4e-28
gi|71040098 Rho GTPase activating protein 30 isoform 1 [Homo sap... 123 4e-28
gi|71834861 Rho GTPase activating protein 5 isoform b [Homo sapi... 122 6e-28
gi|71834863 Rho GTPase activating protein 5 isoform a [Homo sapi... 122 8e-28
gi|208022687 GTPase regulator associated with the focal adhesion... 120 2e-27
gi|7662208 GTPase regulator associated with the focal adhesion k... 120 2e-27
gi|50843948 Rho GTPase activating protein 10 [Homo sapiens] 119 9e-27
>gi|40548322 Rho GTPase activating protein 27 isoform a [Homo
sapiens]
Length = 548
Score = 1120 bits (2896), Expect = 0.0
Identities = 548/548 (100%), Positives = 548/548 (100%)
Query: 1 MQPGLSPGSPGDPRPPTPETDYPESLTSYPEEDYSPVGSFGEPGPTSPLTTPPGWSCHVS 60
MQPGLSPGSPGDPRPPTPETDYPESLTSYPEEDYSPVGSFGEPGPTSPLTTPPGWSCHVS
Sbjct: 1 MQPGLSPGSPGDPRPPTPETDYPESLTSYPEEDYSPVGSFGEPGPTSPLTTPPGWSCHVS 60
Query: 61 QDKQMLYTNHFTQEQWVRLEDPHGKPYFYNPEDSSVRWELPQVPVPAPRSIHKSSQDGDT 120
QDKQMLYTNHFTQEQWVRLEDPHGKPYFYNPEDSSVRWELPQVPVPAPRSIHKSSQDGDT
Sbjct: 61 QDKQMLYTNHFTQEQWVRLEDPHGKPYFYNPEDSSVRWELPQVPVPAPRSIHKSSQDGDT 120
Query: 121 PAQASPPEEKVPAELDEVGSWEEVSPATAAVRTKTLDKAGVLHRTKTADKGKRLRKKHWS 180
PAQASPPEEKVPAELDEVGSWEEVSPATAAVRTKTLDKAGVLHRTKTADKGKRLRKKHWS
Sbjct: 121 PAQASPPEEKVPAELDEVGSWEEVSPATAAVRTKTLDKAGVLHRTKTADKGKRLRKKHWS 180
Query: 181 ASWTVLEGGVLTFFKDSKTSAAGGLRQPSKFSTPEYTVELRGATLSWAPKDKSSRKNVLE 240
ASWTVLEGGVLTFFKDSKTSAAGGLRQPSKFSTPEYTVELRGATLSWAPKDKSSRKNVLE
Sbjct: 181 ASWTVLEGGVLTFFKDSKTSAAGGLRQPSKFSTPEYTVELRGATLSWAPKDKSSRKNVLE 240
Query: 241 LRSRDGSEYLIQHDSEAIISTWHKAIAQGIQELSAELPPEESESSRVDFGSSERLGSWQE 300
LRSRDGSEYLIQHDSEAIISTWHKAIAQGIQELSAELPPEESESSRVDFGSSERLGSWQE
Sbjct: 241 LRSRDGSEYLIQHDSEAIISTWHKAIAQGIQELSAELPPEESESSRVDFGSSERLGSWQE 300
Query: 301 KEEDARPNAAAPALGPVGLESDLSKVRHKLRKFLQRRPTLQSLREKGYIKDQVFGCALAA 360
KEEDARPNAAAPALGPVGLESDLSKVRHKLRKFLQRRPTLQSLREKGYIKDQVFGCALAA
Sbjct: 301 KEEDARPNAAAPALGPVGLESDLSKVRHKLRKFLQRRPTLQSLREKGYIKDQVFGCALAA 360
Query: 361 LCERERSRVPRFVQQCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHDERLDLDDGRW 420
LCERERSRVPRFVQQCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHDERLDLDDGRW
Sbjct: 361 LCERERSRVPRFVQQCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHDERLDLDDGRW 420
Query: 421 EDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDT 480
EDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDT
Sbjct: 421 EDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDT 480
Query: 481 LRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEETSMPMTMVFQNQVVELILQQ 540
LRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEETSMPMTMVFQNQVVELILQQ
Sbjct: 481 LRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEETSMPMTMVFQNQVVELILQQ 540
Query: 541 CADIFPPH 548
CADIFPPH
Sbjct: 541 CADIFPPH 548
>gi|226693398 Rho GTPase activating protein 27 isoform b [Homo
sapiens]
Length = 521
Score = 1043 bits (2697), Expect = 0.0
Identities = 521/548 (95%), Positives = 521/548 (95%), Gaps = 27/548 (4%)
Query: 1 MQPGLSPGSPGDPRPPTPETDYPESLTSYPEEDYSPVGSFGEPGPTSPLTTPPGWSCHVS 60
MQPGLSPGSPGDPRPPTPETDYPESLTSYPEEDYSPVGSFGEPGPTSPLTTPPGWSCHVS
Sbjct: 1 MQPGLSPGSPGDPRPPTPETDYPESLTSYPEEDYSPVGSFGEPGPTSPLTTPPGWSCHVS 60
Query: 61 QDKQMLYTNHFTQEQWVRLEDPHGKPYFYNPEDSSVRWELPQVPVPAPRSIHKSSQDGDT 120
QDKQMLYTNHFTQEQ VPVPAPRSIHKSSQDGDT
Sbjct: 61 QDKQMLYTNHFTQEQ---------------------------VPVPAPRSIHKSSQDGDT 93
Query: 121 PAQASPPEEKVPAELDEVGSWEEVSPATAAVRTKTLDKAGVLHRTKTADKGKRLRKKHWS 180
PAQASPPEEKVPAELDEVGSWEEVSPATAAVRTKTLDKAGVLHRTKTADKGKRLRKKHWS
Sbjct: 94 PAQASPPEEKVPAELDEVGSWEEVSPATAAVRTKTLDKAGVLHRTKTADKGKRLRKKHWS 153
Query: 181 ASWTVLEGGVLTFFKDSKTSAAGGLRQPSKFSTPEYTVELRGATLSWAPKDKSSRKNVLE 240
ASWTVLEGGVLTFFKDSKTSAAGGLRQPSKFSTPEYTVELRGATLSWAPKDKSSRKNVLE
Sbjct: 154 ASWTVLEGGVLTFFKDSKTSAAGGLRQPSKFSTPEYTVELRGATLSWAPKDKSSRKNVLE 213
Query: 241 LRSRDGSEYLIQHDSEAIISTWHKAIAQGIQELSAELPPEESESSRVDFGSSERLGSWQE 300
LRSRDGSEYLIQHDSEAIISTWHKAIAQGIQELSAELPPEESESSRVDFGSSERLGSWQE
Sbjct: 214 LRSRDGSEYLIQHDSEAIISTWHKAIAQGIQELSAELPPEESESSRVDFGSSERLGSWQE 273
Query: 301 KEEDARPNAAAPALGPVGLESDLSKVRHKLRKFLQRRPTLQSLREKGYIKDQVFGCALAA 360
KEEDARPNAAAPALGPVGLESDLSKVRHKLRKFLQRRPTLQSLREKGYIKDQVFGCALAA
Sbjct: 274 KEEDARPNAAAPALGPVGLESDLSKVRHKLRKFLQRRPTLQSLREKGYIKDQVFGCALAA 333
Query: 361 LCERERSRVPRFVQQCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHDERLDLDDGRW 420
LCERERSRVPRFVQQCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHDERLDLDDGRW
Sbjct: 334 LCERERSRVPRFVQQCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHDERLDLDDGRW 393
Query: 421 EDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDT 480
EDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDT
Sbjct: 394 EDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDT 453
Query: 481 LRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEETSMPMTMVFQNQVVELILQQ 540
LRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEETSMPMTMVFQNQVVELILQQ
Sbjct: 454 LRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEETSMPMTMVFQNQVVELILQQ 513
Query: 541 CADIFPPH 548
CADIFPPH
Sbjct: 514 CADIFPPH 521
>gi|26986534 Rho GTPase activating protein 12 [Homo sapiens]
Length = 846
Score = 422 bits (1084), Expect = e-118
Identities = 247/561 (44%), Positives = 339/561 (60%), Gaps = 51/561 (9%)
Query: 9 SPGDPRPPTPETDYPESLTSYPEEDYSPVGSFGEPGPTSPLTTPPGWSCHVSQDKQMLYT 68
+PGD + E +Y TSY + D G P P GWS + + LYT
Sbjct: 311 NPGDQELLSSEENYYS--TSYSQSD----SQCGSP--------PRGWSEELDERGHTLYT 356
Query: 69 NHFTQEQWVRLEDPHGKPYFYNPEDSSVRWELP--------QVPVPAPRSIHKSSQDG-- 118
+ +T E+W++ D G+ Y+Y+ + S WELP Q + RS+ + Q+
Sbjct: 357 SDYTNEKWLKHVDDQGRQYYYSADGSRSEWELPKYNASSQQQREIIKSRSLDRRLQEPIV 416
Query: 119 -----------DTPAQASPPEEKVPAELDEVGSWEEVSPATAAVRTKTLDKAGVLHRTKT 167
DT + SP K P + S A K +K G+L+ TK
Sbjct: 417 LTKWRHSTIVLDTNDKESPTASK-PCFPENESSPSSPKHQDTASSPKDQEKYGLLNVTKI 475
Query: 168 ADKGKRLRKKHWSASWTVLEGGVLTFFKD--SKTSAAGGLRQPSKFSTPEYTVELRGATL 225
A+ GK++RK +W +SW VL+G L F K S TS G S S PE+TV+L+GAT+
Sbjct: 476 AENGKKVRK-NWLSSWAVLQGSSLLFTKTQGSSTSWFG-----SNQSKPEFTVDLKGATI 529
Query: 226 SWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGIQELSAELPPEESESS 285
A KDKSS+KNV EL++R G+E LIQ D++ +I+ W K ++ I + E E E
Sbjct: 530 EMASKDKSSKKNVFELKTRQGTELLIQSDNDTVINDWFKVLSSTINNQAVETD-EGIEEE 588
Query: 286 RVDFGSSERLGSWQEKEEDARPNAAAPALGPVGLES-DLSKVRHKLRKFLQRRPTLQSLR 344
D E+ +KE++ + + ++S + K + L+KFL RRPTLQ++R
Sbjct: 589 IPDSPGIEK----HDKEKEQKDPKKLRSFKVSSIDSSEQKKTKKNLKKFLTRRPTLQAVR 644
Query: 345 EKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGLYRISGNLATIQKLR 404
EKGYIKDQVFG LA LC+RE VP+FV+ CI VE GLDIDG+YR+SGNLA IQKLR
Sbjct: 645 EKGYIKDQVFGSNLANLCQRENGTVPKFVKLCIEHVEEHGLDIDGIYRVSGNLAVIQKLR 704
Query: 405 YKVDHDERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSR 464
+ V+HDE+LDL+D +WED+HVITGALK+FFRELPEPLF F+HF F+ AIK Q+ +R
Sbjct: 705 FAVNHDEKLDLNDSKWEDIHVITGALKMFFRELPEPLFTFNHFNDFVNAIK-QEPRQRVA 763
Query: 465 CVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEETSMP 524
V+DL+R LP PN DT+++LF+HL RVIE+GE+NRM+ QS+AIVFGPTLL+PE E ++
Sbjct: 764 AVKDLIRQLPKPNQDTMQILFRHLRRVIENGEKNRMTYQSIAIVFGPTLLKPEKETGNIA 823
Query: 525 MTMVFQNQVVELILQQCADIF 545
+ V+QNQ+VELIL + + IF
Sbjct: 824 VHTVYQNQIVELILLELSSIF 844
>gi|188497642 ARHGAP15 [Homo sapiens]
Length = 475
Score = 356 bits (914), Expect = 3e-98
Identities = 191/397 (48%), Positives = 264/397 (66%), Gaps = 13/397 (3%)
Query: 156 LDKAGVLHRTKTADKGKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAGGLRQPSKFSTPE 215
++K G L + K AD GK+LRK +WS SW VL + F+K+SK A ++ K PE
Sbjct: 80 VEKEGYLQKAKIADGGKKLRK-NWSTSWIVLSSRRIEFYKESKQQALSNMKTGHK---PE 135
Query: 216 YTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGIQEL-- 273
+V+L GA + WA K+KSSRKNV ++ + G+E+L+Q D + II W AI I L
Sbjct: 136 -SVDLCGAHIEWA-KEKSSRKNVFQITTVSGNEFLLQSDIDFIILDWFHAIKNAIDRLPK 193
Query: 274 SAELPPEESESSRVDFGSSERLGSW-----QEKEEDARPNAAAPALGPVGLESDLSKVRH 328
+ P E ++ SS L S +E++ + R + SD ++V+
Sbjct: 194 DSSCPSRNLELFKIQRSSSTELLSHYDSDIKEQKPEHRKSLMFRLHHSASDTSDKNRVKS 253
Query: 329 KLRKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDID 388
+L+KF+ RRP+L++L+EKG IKDQ+FG L +CERE S VP FV+QCI AVE RGLD+D
Sbjct: 254 RLKKFITRRPSLKTLQEKGLIKDQIFGSHLHKVCERENSTVPWFVKQCIEAVEKRGLDVD 313
Query: 389 GLYRISGNLATIQKLRYKVDHDERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFR 448
G+YR+SGNLATIQKLR+ V+ +E+L+LDD +WED+HV+TGALK+FFRELPEPLFP+S F
Sbjct: 314 GIYRVSGNLATIQKLRFIVNQEEKLNLDDSQWEDIHVVTGALKMFFRELPEPLFPYSFFE 373
Query: 449 QFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIV 508
QF+ AIK QD R V+ LV+ LP PN DT+++LF HL +++ +N MS QS+ IV
Sbjct: 374 QFVEAIKKQDNNTRIEAVKSLVQKLPPPNRDTMKVLFGHLTKIVAKASKNLMSTQSLGIV 433
Query: 509 FGPTLLRPEVEETSMPMTMVFQNQVVELILQQCADIF 545
FGPTLLR E E +M + MV+QNQ+ EL+L + + IF
Sbjct: 434 FGPTLLRAENETGNMAIHMVYQNQIAELMLSEYSKIF 470
>gi|122939147 Rho GTPase activating protein 9 isoform 1 [Homo
sapiens]
Length = 731
Score = 317 bits (812), Expect = 2e-86
Identities = 200/551 (36%), Positives = 295/551 (53%), Gaps = 72/551 (13%)
Query: 48 PLTTPPGWSCHVSQDKQMLYTNHFTQEQWVRLEDPH-GKPYFYNPEDSSVRWELPQVP-- 104
P + PPG +C + Q + W + DP+ G+ ++ N W+ P+
Sbjct: 201 PRSPPPGPACPLLQ----------RLDAWEQHLDPNSGRCFYINSLTGCKSWKPPRRSRS 250
Query: 105 ------VPAPRSIHKSSQDGDTPAQASPPEEKVPAELDEVGSWEEVS-------PATAAV 151
+ +++ +++ A+ + P LD GS PA A
Sbjct: 251 ETNPGSMEGTQTLKRNNDVLQPQAKGFRSDTGTPEPLDPQGSLSLSQRTSQLDPPALQAP 310
Query: 152 RT--------KTLDKAGVLHRTKTADKGKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAG 203
R ++K+G+L+ TK A G++LRK +W SW VL G L F+++ +A
Sbjct: 311 RPLPQLLDDPHEVEKSGLLNMTKIAQGGRKLRK-NWGPSWVVLTGNSLVFYREPPPTAPS 369
Query: 204 GLRQPSKFSTPEYTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWH 263
P+ S PE +V+LRGA L+ + SSR+NVL +R+ G E+L+Q D E + WH
Sbjct: 370 SGWGPAG-SRPESSVDLRGAALAHG-RHLSSRRNVLHIRTIPGHEFLLQSDHETELRAWH 427
Query: 264 KAIAQGIQELSAELPPEESESSRVDFGSSERLGSWQEKEEDARPNAAAPAL--------- 314
+A+ I+ L E P E S GS S E EE+ + P L
Sbjct: 428 RALRTVIERLDRENPLELRLS-----GSGPAELSAGEDEEEESELVSKPLLRLSSRRSSI 482
Query: 315 -GPVGLESDLSKVRHKLRKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFV 373
GP G E + +VR+KL++ + +RP LQSL+E+G ++DQVFGC L +LC+RE VP F+
Sbjct: 483 RGPEGTEQN--RVRNKLKRLIAKRPPLQSLQERGLLRDQVFGCQLESLCQREGDTVPSFL 540
Query: 374 QQCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHDE------------------RLDL 415
+ CI AV+ RGLD+DG+YR+SGNLA +QKLR+ VD + RLDL
Sbjct: 541 RLCIAAVDKRGLDVDGIYRVSGNLAVVQKLRFLVDRERAVTSDGRYVFPEQPGQEGRLDL 600
Query: 416 DDGRWEDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPA 475
D W+D+HV+TGALKLF RELP+PL P F AA+ L + + +++L+ S+P
Sbjct: 601 DSTEWDDIHVVTGALKLFLRELPQPLVPPLLLPHFRAALALSESEQCLSQIQELIGSMPK 660
Query: 476 PNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEETSMPMTMVFQNQVVE 535
PNHDTLR L +HLCRVI H ++NRM+ ++ IVFGPTL RPE E + ++ Q+V+
Sbjct: 661 PNHDTLRYLLEHLCRVIAHSDKNRMTPHNLGIVFGPTLFRPEQETSDPAAHALYPGQLVQ 720
Query: 536 LILQQCADIFP 546
L+L +FP
Sbjct: 721 LMLTNFTSLFP 731
>gi|122939149 Rho GTPase activating protein 9 isoform 3 [Homo
sapiens]
Length = 547
Score = 317 bits (812), Expect = 2e-86
Identities = 200/551 (36%), Positives = 295/551 (53%), Gaps = 72/551 (13%)
Query: 48 PLTTPPGWSCHVSQDKQMLYTNHFTQEQWVRLEDPH-GKPYFYNPEDSSVRWELPQVP-- 104
P + PPG +C + Q + W + DP+ G+ ++ N W+ P+
Sbjct: 17 PRSPPPGPACPLLQ----------RLDAWEQHLDPNSGRCFYINSLTGCKSWKPPRRSRS 66
Query: 105 ------VPAPRSIHKSSQDGDTPAQASPPEEKVPAELDEVGSWEEVS-------PATAAV 151
+ +++ +++ A+ + P LD GS PA A
Sbjct: 67 ETNPGSMEGTQTLKRNNDVLQPQAKGFRSDTGTPEPLDPQGSLSLSQRTSQLDPPALQAP 126
Query: 152 RT--------KTLDKAGVLHRTKTADKGKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAG 203
R ++K+G+L+ TK A G++LRK +W SW VL G L F+++ +A
Sbjct: 127 RPLPQLLDDPHEVEKSGLLNMTKIAQGGRKLRK-NWGPSWVVLTGNSLVFYREPPPTAPS 185
Query: 204 GLRQPSKFSTPEYTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWH 263
P+ S PE +V+LRGA L+ + SSR+NVL +R+ G E+L+Q D E + WH
Sbjct: 186 SGWGPAG-SRPESSVDLRGAALAHG-RHLSSRRNVLHIRTIPGHEFLLQSDHETELRAWH 243
Query: 264 KAIAQGIQELSAELPPEESESSRVDFGSSERLGSWQEKEEDARPNAAAPAL--------- 314
+A+ I+ L E P E S GS S E EE+ + P L
Sbjct: 244 RALRTVIERLDRENPLELRLS-----GSGPAELSAGEDEEEESELVSKPLLRLSSRRSSI 298
Query: 315 -GPVGLESDLSKVRHKLRKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFV 373
GP G E + +VR+KL++ + +RP LQSL+E+G ++DQVFGC L +LC+RE VP F+
Sbjct: 299 RGPEGTEQN--RVRNKLKRLIAKRPPLQSLQERGLLRDQVFGCQLESLCQREGDTVPSFL 356
Query: 374 QQCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHDE------------------RLDL 415
+ CI AV+ RGLD+DG+YR+SGNLA +QKLR+ VD + RLDL
Sbjct: 357 RLCIAAVDKRGLDVDGIYRVSGNLAVVQKLRFLVDRERAVTSDGRYVFPEQPGQEGRLDL 416
Query: 416 DDGRWEDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPA 475
D W+D+HV+TGALKLF RELP+PL P F AA+ L + + +++L+ S+P
Sbjct: 417 DSTEWDDIHVVTGALKLFLRELPQPLVPPLLLPHFRAALALSESEQCLSQIQELIGSMPK 476
Query: 476 PNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEETSMPMTMVFQNQVVE 535
PNHDTLR L +HLCRVI H ++NRM+ ++ IVFGPTL RPE E + ++ Q+V+
Sbjct: 477 PNHDTLRYLLEHLCRVIAHSDKNRMTPHNLGIVFGPTLFRPEQETSDPAAHALYPGQLVQ 536
Query: 536 LILQQCADIFP 546
L+L +FP
Sbjct: 537 LMLTNFTSLFP 547
>gi|122939151 Rho GTPase activating protein 9 isoform 2 [Homo
sapiens]
Length = 640
Score = 236 bits (603), Expect = 3e-62
Identities = 161/456 (35%), Positives = 235/456 (51%), Gaps = 75/456 (16%)
Query: 48 PLTTPPGWSCHVSQDKQMLYTNHFTQEQWVRLEDPH-GKPYFYNPEDSSVRWELPQVP-- 104
P + PPG +C + Q + W + DP+ G+ ++ N W+ P+
Sbjct: 201 PRSPPPGPACPLLQ----------RLDAWEQHLDPNSGRCFYINSLTGCKSWKPPRRSRS 250
Query: 105 ------VPAPRSIHKSSQDGDTPAQASPPEEKVPAELDEVGSWEEVS-------PATAAV 151
+ +++ +++ A+ + P LD GS PA A
Sbjct: 251 ETNPGSMEGTQTLKRNNDVLQPQAKGFRSDTGTPEPLDPQGSLSLSQRTSQLDPPALQAP 310
Query: 152 RT--------KTLDKAGVLHRTKTADKGKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAG 203
R ++K+G+L+ TK A G++LRK +W SW VL G L F+++ +A
Sbjct: 311 RPLPQLLDDPHEVEKSGLLNMTKIAQGGRKLRK-NWGPSWVVLTGNSLVFYREPPPTAPS 369
Query: 204 GLRQPSKFSTPEYTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWH 263
P+ S PE +V+LRGA L+ + SSR+NVL +R+ G E+L+Q D E + WH
Sbjct: 370 SGWGPAG-SRPESSVDLRGAALAHG-RHLSSRRNVLHIRTIPGHEFLLQSDHETELRAWH 427
Query: 264 KAIAQGIQELSAELPPEESESSRVDFGSSERLGSWQEKEEDARPNAAAPAL--------- 314
+A+ I+ L E P E S GS S E EE+ + P L
Sbjct: 428 RALRTVIERLDRENPLELRLS-----GSGPAELSAGEDEEEESELVSKPLLRLSSRRSSI 482
Query: 315 -GPVGLESDLSKVRHKLRKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFV 373
GP G E + +VR+KL++ + +RP LQSL+E+G ++DQVFGC L +LC+RE VP F+
Sbjct: 483 RGPEGTEQN--RVRNKLKRLIAKRPPLQSLQERGLLRDQVFGCQLESLCQREGDTVPSFL 540
Query: 374 QQCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHDE------------------RLDL 415
+ CI AV+ RGLD+DG+YR+SGNLA +QKLR+ VD + RLDL
Sbjct: 541 RLCIAAVDKRGLDVDGIYRVSGNLAVVQKLRFLVDRERAVTSDGRYVFPEQPGQEGRLDL 600
Query: 416 DDGRWEDVHVITGALKLFFRELPEPLFP---FSHFR 448
D W+D+HV+TGALKLF RELP+PL P HFR
Sbjct: 601 DSTEWDDIHVVTGALKLFLRELPQPLVPPLLLPHFR 636
>gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]
Length = 1397
Score = 146 bits (368), Expect = 5e-35
Identities = 122/462 (26%), Positives = 214/462 (46%), Gaps = 42/462 (9%)
Query: 105 VPAPRSIHKSSQDGDTPAQASPPEEKVPAELDEVGSWEEVSPATAAVRTKTLDKAGVLHR 164
+P+ R + DG + + + P++ S ++S AT + + + + ++
Sbjct: 551 IPSLRMLRSFFTDGSLDSWGTSEDADAPSKRH---STSDLSDATFSDIRR---EGWLYYK 604
Query: 165 TKTADKGKRLRK--KHWSASWTVLEGGVLTFFKDSKT---SAAGGLRQPSKFSTPEYTVE 219
KGK+ + W + L L+ K+ + +AAG + E
Sbjct: 605 QILTKKGKKAGSGLRQWKRVYAALRARSLSLSKERREPGPAAAGAAAAGA--GEDEAAPV 662
Query: 220 LRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGIQELSAELPP 279
G+ L ++ R++V L + D EYL Q + + W +AI + + + P
Sbjct: 663 CIGSCLVDISYSETKRRHVFRLTTADFCEYLFQAEDRDDMLGWIRAIRENSRAEGED--P 720
Query: 280 EESESSRVDFGSSERLGSWQEKEEDARPNAAAPALGPVGL---ESDLSKVRHKLRKFLQR 336
+ + + S++L +++ + P A + G GL +S+ K Q
Sbjct: 721 GCANQALI----SKKLNDYRKVSHSSGPKADSSPKGSRGLGGLKSEFLKQSAARGLRTQD 776
Query: 337 RPT---------------LQSLREKGYIKDQVFGCALAALCE--RERSRVPRFVQQCIRA 379
P + +++ + FG L C+ E RVP V C R
Sbjct: 777 LPAGSKDDSAAAPKTPWGINIIKKNKKAAPRAFGVRLEE-CQPATENQRVPLIVAACCRI 835
Query: 380 VEARGLDIDGLYRISGNLATIQKLRYKVDHDER-LDLDDGRWEDVHVITGALKLFFRELP 438
VEARGL+ G+YR+ GN A + L+ +++ ++L D RW+D++VI+ LK FFR+LP
Sbjct: 836 VEARGLESTGIYRVPGNNAVVSSLQEQLNRGPGDINLQDERWQDLNVISSLLKSFFRKLP 895
Query: 439 EPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQN 498
EPLF + FI A +++D R R +R L+R LP ++TL+ L HL + +H E+N
Sbjct: 896 EPLFTDDKYNDFIEANRIEDARERMRTLRKLIRDLPGHYYETLKFLVGHLKTIADHSEKN 955
Query: 499 RMSVQSVAIVFGPTLLR-PEVEETSMPMTMVFQNQVVELILQ 539
+M +++A+VFGPTL+R E T M M + ++VE ++Q
Sbjct: 956 KMEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRYKIVETLIQ 997
>gi|23510413 sorting nexin 26 [Homo sapiens]
Length = 1126
Score = 141 bits (356), Expect = 1e-33
Identities = 107/358 (29%), Positives = 168/358 (46%), Gaps = 41/358 (11%)
Query: 222 GATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGIQELSAE----- 276
G L+W D R+ +L E + + A + AQ ELS E
Sbjct: 160 GPVLTWMELDNHGRRLLLS------EEASLNIPAVAAAHVIKRYTAQAPDELSFEVGDIV 213
Query: 277 ----LPPEESES-------SRVDFGSSE-------RLGSWQEKEEDARPNAAAPALGPVG 318
+PP E S +V F SE R G + + D P G
Sbjct: 214 SVIDMPPTEDRSWWRGKRGFQVGFFPSECVELFTERPGPGLKADADGPPCGIPAPQGISS 273
Query: 319 LESDLSKVRHKL----RKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQ 374
L S + + R KL R F++ RP+ Q LR++G ++ +VFGC L VP+ ++
Sbjct: 274 LTSAVPRPRGKLAGLLRTFMRSRPSRQRLRQRGILRQRVFGCDLGEHLSNSGQDVPQVLR 333
Query: 375 QCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHDERLDLDDGRW-EDVHVITGALKLF 433
C +EA G+ +DG+YR+SG + IQ+LR++ D + +L + +D+H ++ KL+
Sbjct: 334 CCSEFIEAHGV-VDGIYRLSGVSSNIQRLRHEFDSERIPELSGPAFLQDIHSVSSLCKLY 392
Query: 434 FRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIE 493
FRELP PL + + +F A+ + + R V D+++ LP P++ TL L +HL R+
Sbjct: 393 FRELPNPLLTYQLYGKFSEAMSVPGEEERLVRVHDVIQQLPPPHYRTLEYLLRHLARMAR 452
Query: 494 HGEQNRMSVQSVAIVFGPTLLRP-EVEETSMPMTMVF-----QNQVVELILQQCADIF 545
H M +++AIV+ P LLR E+E M F Q+ VVE +L +F
Sbjct: 453 HSANTSMHARNLAIVWAPNLLRSMELESVGMGGAAAFREVRVQSVVVEFLLTHVDVLF 510
>gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens]
Length = 459
Score = 139 bits (349), Expect = 9e-33
Identities = 71/190 (37%), Positives = 119/190 (62%), Gaps = 2/190 (1%)
Query: 352 QVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHD- 410
+V+ C L L + ++ P V CIR +E+RGL+ +GLYR+SG I+ ++ D D
Sbjct: 264 KVYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDG 323
Query: 411 ERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLV 470
E+ D+ +ED+++ITGALKL+FR+LP PL + + +FI + K+ D + + + +
Sbjct: 324 EKADISVNMYEDINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEAL 383
Query: 471 RSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLR-PEVEETSMPMTMVF 529
+ LP + +TLR L HL RV H ++N M+ +++ IVFGPTL+R PE++ + + +
Sbjct: 384 KLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALNDIRY 443
Query: 530 QNQVVELILQ 539
Q VVEL+++
Sbjct: 444 QRLVVELLIK 453
>gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens]
Length = 433
Score = 139 bits (349), Expect = 9e-33
Identities = 71/190 (37%), Positives = 119/190 (62%), Gaps = 2/190 (1%)
Query: 352 QVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHD- 410
+V+ C L L + ++ P V CIR +E+RGL+ +GLYR+SG I+ ++ D D
Sbjct: 238 KVYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDG 297
Query: 411 ERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLV 470
E+ D+ +ED+++ITGALKL+FR+LP PL + + +FI + K+ D + + + +
Sbjct: 298 EKADISVNMYEDINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEAL 357
Query: 471 RSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLR-PEVEETSMPMTMVF 529
+ LP + +TLR L HL RV H ++N M+ +++ IVFGPTL+R PE++ + + +
Sbjct: 358 KLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALNDIRY 417
Query: 530 QNQVVELILQ 539
Q VVEL+++
Sbjct: 418 QRLVVELLIK 427
>gi|203097003 Rho GTPase activating protein 21 [Homo sapiens]
Length = 1958
Score = 139 bits (349), Expect = 9e-33
Identities = 121/411 (29%), Positives = 185/411 (45%), Gaps = 40/411 (9%)
Query: 158 KAGVLH-RTKTADKGKRLRK--KHWSASWTVLEGGVLTFFKDSKTSAAGGLRQPSKFSTP 214
K G LH R DKGKR+ + W + VL G L +KD + PS+ P
Sbjct: 934 KEGWLHFRPLVTDKGKRVGGSIRPWKQMYVVLRGHSLYLYKDKREQTT-----PSEEEQP 988
Query: 215 EYTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQG--IQE 272
A L ++ RKNV L + D E L Q + + W K I + + E
Sbjct: 989 ISV----NACLIDISYSETKRKNVFRLTTSD-CECLFQAEDRDDMLAWIKTIQESSNLNE 1043
Query: 273 LSAELPPEESESSRVD-----FGSSERLGSWQEKEEDARPNAAAPALGPVGLESDLSKVR 327
+ + S R+ +E+L + R P +S S
Sbjct: 1044 EDTGVTNRDLISRRIKEYNNLMSKAEQLPKTPRQSLSIRQTLLGAKSEPK-TQSPHSPKE 1102
Query: 328 HKLRKFLQRRPT------------LQSLREKGYIKDQV----FGCALAALCERERSR-VP 370
RK L + T + S+ K + K FG L +R +P
Sbjct: 1103 ESERKLLSKDDTSPPKDKGTWRKGIPSIMRKTFEKKPTATGTFGVRLDDCPPAHTNRYIP 1162
Query: 371 RFVQQCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHDER-LDLDDGRWEDVHVITGA 429
V C + VE RGL+ G+YR+ GN A I ++ +++ +D+ D +W D++VI+
Sbjct: 1163 LIVDICCKLVEERGLEYTGIYRVPGNNAAISSMQEELNKGMADIDIQDDKWRDLNVISSL 1222
Query: 430 LKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLC 489
LK FFR+LPEPLF + FI A + +D R + ++ L+ LP +++TL+ L HL
Sbjct: 1223 LKSFFRKLPEPLFTNDKYADFIEANRKEDPLDRLKTLKRLIHDLPEHHYETLKFLSAHLK 1282
Query: 490 RVIEHGEQNRMSVQSVAIVFGPTLLR-PEVEETSMPMTMVFQNQVVELILQ 539
V E+ E+N+M +++AIVFGPTL+R E T M M Q ++VE ++Q
Sbjct: 1283 TVAENSEKNKMEPRNLAIVFGPTLVRTSEDNMTHMVTHMPDQYKIVETLIQ 1333
>gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens]
Length = 1227
Score = 138 bits (347), Expect = 1e-32
Identities = 85/208 (40%), Positives = 121/208 (58%), Gaps = 10/208 (4%)
Query: 318 GLESDLSKVRHKLRKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCI 377
G+E LS V+ R+F +R + S ++ G VFG +A + +RERS+VP V+QC+
Sbjct: 980 GIEVKLS-VKFNSREFSLKR--MPSRKQTG-----VFGVKIAVVTKRERSKVPYIVRQCV 1031
Query: 378 RAVEARGLDIDGLYRISGNLATIQKLRYKVDHDERLDLDDGRWE-DVHVITGALKLFFRE 436
+E RG++ G+YR+SG IQ L+ D + + D+ E DV+ I G LKL+FRE
Sbjct: 1032 EEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNK-DVSVMMSEMDVNAIAGTLKLYFRE 1090
Query: 437 LPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGE 496
LPEPLF + F I L D + C+ +L+ SLP N T L HL RV E
Sbjct: 1091 LPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEA 1150
Query: 497 QNRMSVQSVAIVFGPTLLRPEVEETSMP 524
N+MS+ ++A VFGPTLLRP +E+ +P
Sbjct: 1151 VNKMSLHNLATVFGPTLLRPSEKESKLP 1178
>gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens]
Length = 1271
Score = 138 bits (347), Expect = 1e-32
Identities = 85/208 (40%), Positives = 121/208 (58%), Gaps = 10/208 (4%)
Query: 318 GLESDLSKVRHKLRKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCI 377
G+E LS V+ R+F +R + S ++ G VFG +A + +RERS+VP V+QC+
Sbjct: 1024 GIEVKLS-VKFNSREFSLKR--MPSRKQTG-----VFGVKIAVVTKRERSKVPYIVRQCV 1075
Query: 378 RAVEARGLDIDGLYRISGNLATIQKLRYKVDHDERLDLDDGRWE-DVHVITGALKLFFRE 436
+E RG++ G+YR+SG IQ L+ D + + D+ E DV+ I G LKL+FRE
Sbjct: 1076 EEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNK-DVSVMMSEMDVNAIAGTLKLYFRE 1134
Query: 437 LPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGE 496
LPEPLF + F I L D + C+ +L+ SLP N T L HL RV E
Sbjct: 1135 LPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEA 1194
Query: 497 QNRMSVQSVAIVFGPTLLRPEVEETSMP 524
N+MS+ ++A VFGPTLLRP +E+ +P
Sbjct: 1195 VNKMSLHNLATVFGPTLLRPSEKESKLP 1222
>gi|229094128 active breakpoint cluster region-related protein
isoform c [Homo sapiens]
Length = 813
Score = 137 bits (346), Expect = 2e-32
Identities = 83/198 (41%), Positives = 114/198 (57%), Gaps = 8/198 (4%)
Query: 332 KFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGLY 391
KF R +L+ K + VFG ++ + +RERS+VP V+QC+ VE RG++ G+Y
Sbjct: 579 KFTSRDMSLKRTPSKK--QTGVFGVKISVVTKRERSKVPYIVRQCVEEVEKRGIEEVGIY 636
Query: 392 RISGNLATIQKLRYKVDHDER---LDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFR 448
RISG IQ L+ D + + L L D D++ I G LKL+FRELPEPL +
Sbjct: 637 RISGVATDIQALKAVFDANNKDILLMLSD---MDINAIAGTLKLYFRELPEPLLTDRLYP 693
Query: 449 QFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIV 508
F+ I L D A + C+ L+RSLP PN T L +HL RV E N+MS+ ++A V
Sbjct: 694 AFMEGIALSDPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATV 753
Query: 509 FGPTLLRPEVEETSMPMT 526
FGPTLLRP E+ +T
Sbjct: 754 FGPTLLRPSEVESKAHLT 771
>gi|38679957 active breakpoint cluster region-related protein
isoform a [Homo sapiens]
Length = 859
Score = 137 bits (346), Expect = 2e-32
Identities = 83/198 (41%), Positives = 114/198 (57%), Gaps = 8/198 (4%)
Query: 332 KFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGLY 391
KF R +L+ K + VFG ++ + +RERS+VP V+QC+ VE RG++ G+Y
Sbjct: 625 KFTSRDMSLKRTPSKK--QTGVFGVKISVVTKRERSKVPYIVRQCVEEVEKRGIEEVGIY 682
Query: 392 RISGNLATIQKLRYKVDHDER---LDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFR 448
RISG IQ L+ D + + L L D D++ I G LKL+FRELPEPL +
Sbjct: 683 RISGVATDIQALKAVFDANNKDILLMLSD---MDINAIAGTLKLYFRELPEPLLTDRLYP 739
Query: 449 QFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIV 508
F+ I L D A + C+ L+RSLP PN T L +HL RV E N+MS+ ++A V
Sbjct: 740 AFMEGIALSDPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATV 799
Query: 509 FGPTLLRPEVEETSMPMT 526
FGPTLLRP E+ +T
Sbjct: 800 FGPTLLRPSEVESKAHLT 817
>gi|38679954 active breakpoint cluster region-related protein
isoform b [Homo sapiens]
Length = 822
Score = 137 bits (346), Expect = 2e-32
Identities = 83/198 (41%), Positives = 114/198 (57%), Gaps = 8/198 (4%)
Query: 332 KFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGLY 391
KF R +L+ K + VFG ++ + +RERS+VP V+QC+ VE RG++ G+Y
Sbjct: 588 KFTSRDMSLKRTPSKK--QTGVFGVKISVVTKRERSKVPYIVRQCVEEVEKRGIEEVGIY 645
Query: 392 RISGNLATIQKLRYKVDHDER---LDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFR 448
RISG IQ L+ D + + L L D D++ I G LKL+FRELPEPL +
Sbjct: 646 RISGVATDIQALKAVFDANNKDILLMLSD---MDINAIAGTLKLYFRELPEPLLTDRLYP 702
Query: 449 QFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIV 508
F+ I L D A + C+ L+RSLP PN T L +HL RV E N+MS+ ++A V
Sbjct: 703 AFMEGIALSDPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATV 762
Query: 509 FGPTLLRPEVEETSMPMT 526
FGPTLLRP E+ +T
Sbjct: 763 FGPTLLRPSEVESKAHLT 780
>gi|150417981 glucocorticoid receptor DNA binding factor 1 [Homo
sapiens]
Length = 1499
Score = 136 bits (342), Expect = 6e-32
Identities = 77/262 (29%), Positives = 141/262 (53%), Gaps = 9/262 (3%)
Query: 290 GSSERLGSWQEKEEDARPNAAAPALGPVGLESDLSKVRHKLRKFLQR-----RPTLQSLR 344
GS + LG ++KEED + E+D R + + L+R +P +
Sbjct: 1178 GSDDELGPIRKKEEDQASQGYKGDNAVIPYETDEDPRRRNILRSLRRNTKKPKPKPRPSI 1237
Query: 345 EKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGLYRISGNLATIQKLR 404
K + FG L + E+ +P F+++CI +EA GL +G+YR+SGN + ++ L+
Sbjct: 1238 TKATWESNYFGVPLTTVVTPEKP-IPIFIERCIEYIEATGLSTEGIYRVSGNKSEMESLQ 1296
Query: 405 YKVDHDERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSR 464
+ D D LDL + + V+ + GA+K FF ELP+PL P++ + A K+ D+ ++
Sbjct: 1297 RQFDQDHNLDLAEKDFT-VNTVAGAMKSFFSELPDPLVPYNMQIDLVEAHKINDREQKLH 1355
Query: 465 CVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEE-TSM 523
++++++ P NH+ + + HL +V + + N M+ ++++I F PTL+RP+ ++
Sbjct: 1356 ALKEVLKKFPKENHEVFKYVISHLNKVSHNNKVNLMTSENLSICFWPTLMRPDFSTMDAL 1415
Query: 524 PMTMVFQNQVVELILQQCADIF 545
T +Q ++EL +QQC F
Sbjct: 1416 TATRTYQT-IIELFIQQCPFFF 1436
>gi|4757980 beta chimerin isoform 2 [Homo sapiens]
Length = 468
Score = 132 bits (331), Expect = 1e-30
Identities = 68/190 (35%), Positives = 116/190 (61%), Gaps = 2/190 (1%)
Query: 352 QVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHD- 410
+V+ C L L + ++ P V CIR +EARGL +GLYR+SG I+ ++ D D
Sbjct: 273 KVYCCDLTTLVKAHNTQRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDG 332
Query: 411 ERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLV 470
E+ D+ + D+++ITGALKL+FR+LP P+ + + +FI A K+ + R V +++
Sbjct: 333 EKADISANVYPDINIITGALKLYFRDLPIPVITYDTYSKFIDAAKISNADERLEAVHEVL 392
Query: 471 RSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEETSMPM-TMVF 529
LP +++TLR L HL +V + + N M+ +++ IVFGPTL+RP + T + M +
Sbjct: 393 MLLPPAHYETLRYLMIHLKKVTMNEKDNFMNAENLGIVFGPTLMRPPEDSTLTTLHDMRY 452
Query: 530 QNQVVELILQ 539
Q +V+++++
Sbjct: 453 QKLIVQILIE 462
>gi|91106928 beta chimerin isoform 1 [Homo sapiens]
Length = 332
Score = 132 bits (331), Expect = 1e-30
Identities = 68/190 (35%), Positives = 116/190 (61%), Gaps = 2/190 (1%)
Query: 352 QVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHD- 410
+V+ C L L + ++ P V CIR +EARGL +GLYR+SG I+ ++ D D
Sbjct: 137 KVYCCDLTTLVKAHNTQRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDG 196
Query: 411 ERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLV 470
E+ D+ + D+++ITGALKL+FR+LP P+ + + +FI A K+ + R V +++
Sbjct: 197 EKADISANVYPDINIITGALKLYFRDLPIPVITYDTYSKFIDAAKISNADERLEAVHEVL 256
Query: 471 RSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEETSMPM-TMVF 529
LP +++TLR L HL +V + + N M+ +++ IVFGPTL+RP + T + M +
Sbjct: 257 MLLPPAHYETLRYLMIHLKKVTMNEKDNFMNAENLGIVFGPTLMRPPEDSTLTTLHDMRY 316
Query: 530 QNQVVELILQ 539
Q +V+++++
Sbjct: 317 QKLIVQILIE 326
>gi|218083800 Rho GTPase-activating protein isoform 1 [Homo sapiens]
Length = 2087
Score = 132 bits (331), Expect = 1e-30
Identities = 75/223 (33%), Positives = 123/223 (55%), Gaps = 8/223 (3%)
Query: 330 LRKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDG 389
LR F++ RPT Q L+++G +K++VFGC L VP+ +Q C +E G+ +DG
Sbjct: 346 LRTFMKSRPTKQKLKQRGILKERVFGCDLGEHLLNSGFEVPQVLQSCTAFIERYGI-VDG 404
Query: 390 LYRISGNLATIQKLRYKVDHDERLDLDDGRW-EDVHVITGALKLFFRELPEPLFPFSHFR 448
+YR+SG + IQ+LR++ D + DL + +D+H + KL+FRELP PL + +
Sbjct: 405 IYRLSGVASNIQRLRHEFDSEHVPDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYE 464
Query: 449 QFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIV 508
+F A+ R + D+++ LP P++ TL L +HL + ++ M +++AIV
Sbjct: 465 KFSDAVSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIV 524
Query: 509 FGPTLLRPEVEE------TSMPMTMVFQNQVVELILQQCADIF 545
+ P LLR + E T+ M + Q+ VVE IL +F
Sbjct: 525 WAPNLLRSKQIESACFSGTAAFMEVRIQSVVVEFILNHVDVLF 567
>gi|29469071 Rho GTPase-activating protein isoform 2 [Homo sapiens]
Length = 1738
Score = 126 bits (317), Expect = 4e-29
Identities = 72/219 (32%), Positives = 120/219 (54%), Gaps = 8/219 (3%)
Query: 334 LQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGLYRI 393
++ RPT Q L+++G +K++VFGC L VP+ +Q C +E G+ +DG+YR+
Sbjct: 1 MKSRPTKQKLKQRGILKERVFGCDLGEHLLNSGFEVPQVLQSCTAFIERYGI-VDGIYRL 59
Query: 394 SGNLATIQKLRYKVDHDERLDLDDGRW-EDVHVITGALKLFFRELPEPLFPFSHFRQFIA 452
SG + IQ+LR++ D + DL + +D+H + KL+FRELP PL + + +F
Sbjct: 60 SGVASNIQRLRHEFDSEHVPDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSD 119
Query: 453 AIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPT 512
A+ R + D+++ LP P++ TL L +HL + ++ M +++AIV+ P
Sbjct: 120 AVSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPN 179
Query: 513 LLRPEVEE------TSMPMTMVFQNQVVELILQQCADIF 545
LLR + E T+ M + Q+ VVE IL +F
Sbjct: 180 LLRSKQIESACFSGTAAFMEVRIQSVVVEFILNHVDVLF 218
>gi|221307575 Rho-type GTPase-activating protein FLJ32810 [Homo
sapiens]
Length = 874
Score = 125 bits (315), Expect = 8e-29
Identities = 70/177 (39%), Positives = 103/177 (58%), Gaps = 4/177 (2%)
Query: 372 FVQQCIRAVEARGLDIDGLYRISGNLATIQKLR---YKVDHDERLDLDDGRWEDVHVITG 428
FV++CI+AVE RG+ I GLYRI G + +QKL + +D+D W++ IT
Sbjct: 397 FVRKCIQAVETRGITILGLYRIGGVNSKVQKLMNTTFSPKSPPDIDIDIELWDN-KTITS 455
Query: 429 ALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHL 488
LK + R L EPL + + FI A+K DQ R V LV LP N + L +L +HL
Sbjct: 456 GLKNYLRCLAEPLMTYKLHKDFIIAVKSDDQNYRVEAVHALVHKLPEKNREMLDILIKHL 515
Query: 489 CRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEETSMPMTMVFQNQVVELILQQCADIF 545
+V H +QN M+V ++ ++FGPTL+R + E + M + FQN VVE++++ IF
Sbjct: 516 VKVSLHSQQNLMTVSNLGVIFGPTLMRAQEETVAAMMNIKFQNIVVEILIEHYEKIF 572
>gi|71040096 Rho GTPase activating protein 30 isoform 2 [Homo
sapiens]
Length = 890
Score = 123 bits (309), Expect = 4e-28
Identities = 72/212 (33%), Positives = 117/212 (55%), Gaps = 8/212 (3%)
Query: 341 QSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGLYRISGNLATI 400
Q ++KG K++VFGC L + VP+ ++ C VE G+ +DG+YR+SG + I
Sbjct: 5 QKGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGV-VDGIYRLSGVSSNI 63
Query: 401 QKLRYKVDHDERLDLD-DGRWEDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQ 459
QKLR + + + + DL D +D+H ++ K +FRELP+PL + + +F A+ +Q +
Sbjct: 64 QKLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGVQLE 123
Query: 460 ARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLR-PEV 518
R + +++R LP PN+ TL L +HL + Q M +++AIV+ P LLR ++
Sbjct: 124 PERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDI 183
Query: 519 EETSMPMTMVF-----QNQVVELILQQCADIF 545
E + T F Q+ VVE IL +F
Sbjct: 184 EASGFNGTAAFMEVRVQSIVVEFILTHVDQLF 215
>gi|71040098 Rho GTPase activating protein 30 isoform 1 [Homo
sapiens]
Length = 1101
Score = 123 bits (309), Expect = 4e-28
Identities = 72/212 (33%), Positives = 117/212 (55%), Gaps = 8/212 (3%)
Query: 341 QSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGLYRISGNLATI 400
Q ++KG K++VFGC L + VP+ ++ C VE G+ +DG+YR+SG + I
Sbjct: 5 QKGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGV-VDGIYRLSGVSSNI 63
Query: 401 QKLRYKVDHDERLDLD-DGRWEDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQ 459
QKLR + + + + DL D +D+H ++ K +FRELP+PL + + +F A+ +Q +
Sbjct: 64 QKLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGVQLE 123
Query: 460 ARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLR-PEV 518
R + +++R LP PN+ TL L +HL + Q M +++AIV+ P LLR ++
Sbjct: 124 PERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDI 183
Query: 519 EETSMPMTMVF-----QNQVVELILQQCADIF 545
E + T F Q+ VVE IL +F
Sbjct: 184 EASGFNGTAAFMEVRVQSIVVEFILTHVDQLF 215
>gi|71834861 Rho GTPase activating protein 5 isoform b [Homo sapiens]
Length = 1501
Score = 122 bits (307), Expect = 6e-28
Identities = 69/227 (30%), Positives = 118/227 (51%), Gaps = 3/227 (1%)
Query: 320 ESDLSKVRHKLRKFLQRRPTLQ-SLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIR 378
+ + K HK+++ +++ T + + + FG L L E+ +P FV++C+
Sbjct: 1224 DKKMKKKTHKVKEDKKKKKTKNFNPPTRRNWESNYFGMPLQDLVTAEKP-IPLFVEKCVE 1282
Query: 379 AVEARGLDIDGLYRISGNLATIQKLRYKVDHDERLDLDDGRWEDVHVITGALKLFFRELP 438
+E GL +GLYR+SGN ++ + D D ++L V+ + GALK FF +LP
Sbjct: 1283 FIEDTGLCTEGLYRVSGNKTDQDNIQKQFDQDHNINLVSME-VTVNAVAGALKAFFADLP 1341
Query: 439 EPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQN 498
+PL P+S + + A K+ D+ R ++++V+ N+D R + HL RV + + N
Sbjct: 1342 DPLIPYSLHPELLEAAKIPDKTERLHALKEIVKKFHPVNYDVFRYVITHLNRVSQQHKIN 1401
Query: 499 RMSVQSVAIVFGPTLLRPEVEETSMPMTMVFQNQVVELILQQCADIF 545
M+ +++I F PTL+RP+ E T VVE +QQC F
Sbjct: 1402 LMTADNLSICFWPTLMRPDFENREFLSTTKIHQSVVETFIQQCQFFF 1448
>gi|71834863 Rho GTPase activating protein 5 isoform a [Homo sapiens]
Length = 1502
Score = 122 bits (306), Expect = 8e-28
Identities = 68/228 (29%), Positives = 118/228 (51%), Gaps = 4/228 (1%)
Query: 320 ESDLSKVRHKLRKFLQRRPTLQSLRE--KGYIKDQVFGCALAALCERERSRVPRFVQQCI 377
+ + K HK+++ +++ ++ + + FG L L E+ +P FV++C+
Sbjct: 1224 DKKMKKKTHKVKEDKKQKKKTKNFNPPTRRNWESNYFGMPLQDLVTAEKP-IPLFVEKCV 1282
Query: 378 RAVEARGLDIDGLYRISGNLATIQKLRYKVDHDERLDLDDGRWEDVHVITGALKLFFREL 437
+E GL +GLYR+SGN ++ + D D ++L V+ + GALK FF +L
Sbjct: 1283 EFIEDTGLCTEGLYRVSGNKTDQDNIQKQFDQDHNINLVSME-VTVNAVAGALKAFFADL 1341
Query: 438 PEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQ 497
P+PL P+S + + A K+ D+ R ++++V+ N+D R + HL RV + +
Sbjct: 1342 PDPLIPYSLHPELLEAAKIPDKTERLHALKEIVKKFHPVNYDVFRYVITHLNRVSQQHKI 1401
Query: 498 NRMSVQSVAIVFGPTLLRPEVEETSMPMTMVFQNQVVELILQQCADIF 545
N M+ +++I F PTL+RP+ E T VVE +QQC F
Sbjct: 1402 NLMTADNLSICFWPTLMRPDFENREFLSTTKIHQSVVETFIQQCQFFF 1449
>gi|208022687 GTPase regulator associated with the focal adhesion
kinase pp125 isoform b [Homo sapiens]
Length = 759
Score = 120 bits (302), Expect = 2e-27
Identities = 70/178 (39%), Positives = 101/178 (56%), Gaps = 7/178 (3%)
Query: 373 VQQCIRAVEARGLDIDGLYRISGNLATIQKLRY-----KVDHDERLDLDDGRWEDVHVIT 427
+++CI AVE RG++ GLYRI G + +QKL K + D+ WE + IT
Sbjct: 393 IRKCIHAVETRGINEQGLYRIVGVNSRVQKLLSVLMDPKTASETETDIC-AEWE-IKTIT 450
Query: 428 GALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQH 487
ALK + R LP PL + R FI A KL++Q R + LV LP N L++L H
Sbjct: 451 SALKTYLRMLPGPLMMYQFQRSFIKAAKLENQESRVSEIHSLVHRLPEKNRQMLQLLMNH 510
Query: 488 LCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEETSMPMTMVFQNQVVELILQQCADIF 545
L V + +QN M+V ++ +VFGPTLLRP+ E + M + FQN V+E++++ IF
Sbjct: 511 LANVANNHKQNLMTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVIEILIENHEKIF 568
>gi|7662208 GTPase regulator associated with the focal adhesion
kinase pp125 isoform a [Homo sapiens]
Length = 814
Score = 120 bits (302), Expect = 2e-27
Identities = 70/178 (39%), Positives = 101/178 (56%), Gaps = 7/178 (3%)
Query: 373 VQQCIRAVEARGLDIDGLYRISGNLATIQKLRY-----KVDHDERLDLDDGRWEDVHVIT 427
+++CI AVE RG++ GLYRI G + +QKL K + D+ WE + IT
Sbjct: 393 IRKCIHAVETRGINEQGLYRIVGVNSRVQKLLSVLMDPKTASETETDIC-AEWE-IKTIT 450
Query: 428 GALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQH 487
ALK + R LP PL + R FI A KL++Q R + LV LP N L++L H
Sbjct: 451 SALKTYLRMLPGPLMMYQFQRSFIKAAKLENQESRVSEIHSLVHRLPEKNRQMLQLLMNH 510
Query: 488 LCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEETSMPMTMVFQNQVVELILQQCADIF 545
L V + +QN M+V ++ +VFGPTLLRP+ E + M + FQN V+E++++ IF
Sbjct: 511 LANVANNHKQNLMTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVIEILIENHEKIF 568
>gi|50843948 Rho GTPase activating protein 10 [Homo sapiens]
Length = 786
Score = 119 bits (297), Expect = 9e-27
Identities = 68/180 (37%), Positives = 100/180 (55%), Gaps = 5/180 (2%)
Query: 373 VQQCIRAVEARGLDIDGLYRISGNLATIQKLR---YKVDHDERLDLDDGRWEDVHVITGA 429
+++CI AVE RG++ GLYR+ G + +Q+L V +DL++ +V IT A
Sbjct: 399 IRKCISAVETRGINDQGLYRVVGVSSKVQRLLSMLMDVKTCNEVDLENSADWEVKTITSA 458
Query: 430 LKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLC 489
LK + R LPEPL + FI K R + LV LP N + L +L +HL
Sbjct: 459 LKQYLRSLPEPLMTYELHGDFIVPAKSGSPESRVNAIHFLVHKLPEKNKEMLDILVKHLT 518
Query: 490 RVIEHGEQNRMSVQSVAIVFGPTLLRPEVEETSMPMTMVFQNQVVELILQQCADIF--PP 547
V H +QN M+V ++ +VFGPTL+RP+ E + M + FQN VVE++++ IF PP
Sbjct: 519 NVSNHSKQNLMTVANLGVVFGPTLMRPQEETVAALMDLKFQNIVVEILIENHEKIFRTPP 578
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.133 0.403
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,319,478
Number of Sequences: 37866
Number of extensions: 1393018
Number of successful extensions: 8190
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 137
Number of HSP's successfully gapped in prelim test: 195
Number of HSP's that attempted gapping in prelim test: 7002
Number of HSP's gapped (non-prelim): 1252
length of query: 548
length of database: 18,247,518
effective HSP length: 107
effective length of query: 441
effective length of database: 14,195,856
effective search space: 6260372496
effective search space used: 6260372496
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.