Search of human proteins with 40254871

Search of human proteins with 40254871

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|40254871 transmembrane protease, serine 11E [Homo sapiens]
         (423 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|40254871 transmembrane protease, serine 11E [Homo sapiens]         879   0.0  
gi|153791781 transmembrane protease, serine 11E2 [Homo sapiens]       875   0.0  
gi|167466252 transmembrane protease, serine 11A isoform 2 [Homo ...   368   e-102
gi|167466250 transmembrane protease, serine 11A isoform 1 [Homo ...   365   e-101
gi|194018492 transmembrane protease, serine 11F [Homo sapiens]        349   3e-96
gi|4758508 transmembrane protease, serine 11D [Homo sapiens]          330   1e-90
gi|187761337 transmembrane protease, serine 11B [Homo sapiens]        314   8e-86
gi|11415040 matriptase [Homo sapiens]                                 224   9e-59
gi|33667063 transmembrane protease, serine 9 [Homo sapiens]           218   8e-57
gi|23957702 transmembrane protease, serine 6 [Homo sapiens]           215   5e-56
gi|116256363 transmembrane protease, serine 13 [Homo sapiens]         199   3e-51
gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo sap...   193   2e-49
gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo sa...   191   8e-49
gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo sa...   191   8e-49
gi|170932492 transmembrane protease, serine 5 [Homo sapiens]          191   1e-48
gi|222831592 transmembrane protease, serine 7 [Homo sapiens]          190   2e-48
gi|33695155 hepsin [Homo sapiens]                                     190   2e-48
gi|4504481 hepsin [Homo sapiens]                                      190   2e-48
gi|110815798 ovochymase 1 [Homo sapiens]                              187   2e-47
gi|223942069 enterokinase precursor [Homo sapiens]                    184   2e-46
gi|145701030 transmembrane protease, serine 4 isoform 3 [Homo sa...   184   2e-46
gi|15451940 transmembrane protease, serine 4 isoform 1 [Homo sap...   184   2e-46
gi|13994276 marapsin [Homo sapiens]                                   182   7e-46
gi|5803197 testisin isoform 1 [Homo sapiens]                          179   6e-45
gi|21614531 testisin isoform 2 [Homo sapiens]                         176   3e-44
gi|117956391 protease, serine, 33 [Homo sapiens]                      173   3e-43
gi|205360905 testis-specific serine protease 1 [Homo sapiens]         172   7e-43
gi|78191798 plasma kallikrein B1 precursor [Homo sapiens]             171   9e-43
gi|4503627 coagulation factor XI precursor [Homo sapiens]             171   9e-43
gi|148613878 acrosin precursor [Homo sapiens]                         171   1e-42

>gi|40254871 transmembrane protease, serine 11E [Homo sapiens]
          Length = 423

 Score =  879 bits (2270), Expect = 0.0
 Identities = 423/423 (100%), Positives = 423/423 (100%)

Query: 1   MMYRPDVVRARKRVCWEPWVIGLVIFISLIVLAVCIGLTVHYVRYNQKKTYNYYSTLSFT 60
           MMYRPDVVRARKRVCWEPWVIGLVIFISLIVLAVCIGLTVHYVRYNQKKTYNYYSTLSFT
Sbjct: 1   MMYRPDVVRARKRVCWEPWVIGLVIFISLIVLAVCIGLTVHYVRYNQKKTYNYYSTLSFT 60

Query: 61  TDKLYAEFGREASNNFTEMSQRLESMVKNAFYKSPLREEFVKSQVIKFSQQKHGVLAHML 120
           TDKLYAEFGREASNNFTEMSQRLESMVKNAFYKSPLREEFVKSQVIKFSQQKHGVLAHML
Sbjct: 61  TDKLYAEFGREASNNFTEMSQRLESMVKNAFYKSPLREEFVKSQVIKFSQQKHGVLAHML 120

Query: 121 LICRFHSTEDPETVDKIVQLVLHEKLQDAVGPPKVDPHSVKIKKINKTETDSYLNHCCGT 180
           LICRFHSTEDPETVDKIVQLVLHEKLQDAVGPPKVDPHSVKIKKINKTETDSYLNHCCGT
Sbjct: 121 LICRFHSTEDPETVDKIVQLVLHEKLQDAVGPPKVDPHSVKIKKINKTETDSYLNHCCGT 180

Query: 181 RRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFTTYKNP 240
           RRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFTTYKNP
Sbjct: 181 RRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFTTYKNP 240

Query: 241 ARWTASFGVTIKPSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVPYTNAVHRVCLPD 300
           ARWTASFGVTIKPSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVPYTNAVHRVCLPD
Sbjct: 241 ARWTASFGVTIKPSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVPYTNAVHRVCLPD 300

Query: 301 ASYEFQPGDVMFVTGFGALKNDGYSQNHLRQAQVTLIDATTCNEPQAYNDAITPRMLCAG 360
           ASYEFQPGDVMFVTGFGALKNDGYSQNHLRQAQVTLIDATTCNEPQAYNDAITPRMLCAG
Sbjct: 301 ASYEFQPGDVMFVTGFGALKNDGYSQNHLRQAQVTLIDATTCNEPQAYNDAITPRMLCAG 360

Query: 361 SLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTRVTALRDWITSK 420
           SLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTRVTALRDWITSK
Sbjct: 361 SLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTRVTALRDWITSK 420

Query: 421 TGI 423
           TGI
Sbjct: 421 TGI 423


>gi|153791781 transmembrane protease, serine 11E2 [Homo sapiens]
          Length = 423

 Score =  875 bits (2262), Expect = 0.0
 Identities = 422/423 (99%), Positives = 422/423 (99%)

Query: 1   MMYRPDVVRARKRVCWEPWVIGLVIFISLIVLAVCIGLTVHYVRYNQKKTYNYYSTLSFT 60
           MMYRPDVVRARKRVCWEPWVIGLVIFISLIVLAVCIGLTVHYVRYNQKKTYNYYSTLSFT
Sbjct: 1   MMYRPDVVRARKRVCWEPWVIGLVIFISLIVLAVCIGLTVHYVRYNQKKTYNYYSTLSFT 60

Query: 61  TDKLYAEFGREASNNFTEMSQRLESMVKNAFYKSPLREEFVKSQVIKFSQQKHGVLAHML 120
           TDKLYAEFGREASNNFTEMSQRLESMVKNAFYKSPLREEFVKSQVIKFSQQKHGVLAHML
Sbjct: 61  TDKLYAEFGREASNNFTEMSQRLESMVKNAFYKSPLREEFVKSQVIKFSQQKHGVLAHML 120

Query: 121 LICRFHSTEDPETVDKIVQLVLHEKLQDAVGPPKVDPHSVKIKKINKTETDSYLNHCCGT 180
           LICRFHSTEDPETVDKIVQLVLHEKLQDAVGPPKVDP SVKIKKINKTETDSYLNHCCGT
Sbjct: 121 LICRFHSTEDPETVDKIVQLVLHEKLQDAVGPPKVDPQSVKIKKINKTETDSYLNHCCGT 180

Query: 181 RRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFTTYKNP 240
           RRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFTTYKNP
Sbjct: 181 RRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFTTYKNP 240

Query: 241 ARWTASFGVTIKPSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVPYTNAVHRVCLPD 300
           ARWTASFGVTIKPSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVPYTNAVHRVCLPD
Sbjct: 241 ARWTASFGVTIKPSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVPYTNAVHRVCLPD 300

Query: 301 ASYEFQPGDVMFVTGFGALKNDGYSQNHLRQAQVTLIDATTCNEPQAYNDAITPRMLCAG 360
           ASYEFQPGDVMFVTGFGALKNDGYSQNHLRQAQVTLIDATTCNEPQAYNDAITPRMLCAG
Sbjct: 301 ASYEFQPGDVMFVTGFGALKNDGYSQNHLRQAQVTLIDATTCNEPQAYNDAITPRMLCAG 360

Query: 361 SLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTRVTALRDWITSK 420
           SLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTRVTALRDWITSK
Sbjct: 361 SLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTRVTALRDWITSK 420

Query: 421 TGI 423
           TGI
Sbjct: 421 TGI 423


>gi|167466252 transmembrane protease, serine 11A isoform 2 [Homo
           sapiens]
          Length = 418

 Score =  368 bits (945), Expect = e-102
 Identities = 181/423 (42%), Positives = 273/423 (64%), Gaps = 5/423 (1%)

Query: 1   MMYRPDVVRARKRVCWEPWVIGLVIFISLIVLAVCIGLTVHYVRYNQKKTYNYYSTLSFT 60
           MMYR      R R   +PW+I ++I +SL V+AV IGL VH++ ++QKK Y Y+ +    
Sbjct: 1   MMYRTVGFGTRSRNL-KPWMIAVLIVLSLTVVAVTIGLLVHFLVFDQKKEY-YHGSFKIL 58

Query: 61  TDKLYAEFGREASNNFTEMSQRLESMVKNAFYKSPLREEFVKSQVIKFSQQKHGVLAHML 120
             ++   FG+  +    ++ +  E++V   F  S  ++ ++K+QV++ + ++ GV   ++
Sbjct: 59  DPQINNNFGQSNTYQLKDLRETTENLVDEIFIDSAWKKNYIKNQVVRLTPEEDGVKVDVI 118

Query: 121 LICRFHSTEDPETVDKIVQLVLHEKLQDAVGPPKVDPHSVKIKKINKTETDSYLNHCCGT 180
           ++ +F STE     +K +Q +L++K+++    P ++  SV++  ++ +  +  +   CG 
Sbjct: 119 MVFQFPSTEQRAVREKKIQSILNQKIRNLRALP-INASSVQVNAMSSSTGELTVQASCG- 176

Query: 181 RRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFTTYKNP 240
           +R   L  + RI  G    +  WPWQASLQ+D  H+CGATLI+ TWLV+AAHCF  YKNP
Sbjct: 177 KRVVPLNVN-RIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCFQKYKNP 235

Query: 241 ARWTASFGVTIKPSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVPYTNAVHRVCLPD 300
            +WT SFG  I P  MKR +RR I+HEKY+  + +YDI++ ++SS V +++ + ++CLP+
Sbjct: 236 HQWTVSFGTKINPPLMKRNVRRFIIHEKYRSAAREYDIAVVQVSSRVTFSDDIRQICLPE 295

Query: 301 ASYEFQPGDVMFVTGFGALKNDGYSQNHLRQAQVTLIDATTCNEPQAYNDAITPRMLCAG 360
           AS  FQP   + +TGFGAL   G SQN LR+A+V +I    C +PQ Y + I P M CAG
Sbjct: 296 ASASFQPNLTVHITGFGALYYGGESQNDLREARVKIISDDVCKQPQVYGNDIKPGMFCAG 355

Query: 361 SLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTRVTALRDWITSK 420
            +EG  DAC+GDSGGPLV+ D +D WYL GIVSWGD C + +KPGVYT+VT  R+WI SK
Sbjct: 356 YMEGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKPGVYTQVTYYRNWIASK 415

Query: 421 TGI 423
           TGI
Sbjct: 416 TGI 418


>gi|167466250 transmembrane protease, serine 11A isoform 1 [Homo
           sapiens]
          Length = 421

 Score =  365 bits (936), Expect = e-101
 Identities = 183/426 (42%), Positives = 273/426 (64%), Gaps = 8/426 (1%)

Query: 1   MMYRPDVVRARKRVCWEPWVIGLVIFISLIVLAVCIGLTVHYVRYNQKKTYNYYSTLSFT 60
           MMYR      R R   +PW+I ++I +SL V+AV IGL VH++ ++QKK Y Y+ +    
Sbjct: 1   MMYRTVGFGTRSRNL-KPWMIAVLIVLSLTVVAVTIGLLVHFLVFDQKKEY-YHGSFKIL 58

Query: 61  TDKLYAEFGREAS---NNFTEMSQRLESMVKNAFYKSPLREEFVKSQVIKFSQQKHGVLA 117
             ++   FG+  +    +  E ++ L S V   F  S  ++ ++K+QV++ + ++ GV  
Sbjct: 59  DPQINNNFGQSNTYQLKDLRETTENLVSQVDEIFIDSAWKKNYIKNQVVRLTPEEDGVKV 118

Query: 118 HMLLICRFHSTEDPETVDKIVQLVLHEKLQDAVGPPKVDPHSVKIKKINKTETDSYLNHC 177
            ++++ +F STE     +K +Q +L++K+++    P ++  SV++  ++ +  +  +   
Sbjct: 119 DVIMVFQFPSTEQRAVREKKIQSILNQKIRNLRALP-INASSVQVNAMSSSTGELTVQAS 177

Query: 178 CGTRRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFTTY 237
           CG +R   L  + RI  G    +  WPWQASLQ+D  H+CGATLI+ TWLV+AAHCF  Y
Sbjct: 178 CG-KRVVPLNVN-RIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCFQKY 235

Query: 238 KNPARWTASFGVTIKPSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVPYTNAVHRVC 297
           KNP +WT SFG  I P  MKR +RR I+HEKY+  + +YDI++ ++SS V +++ + ++C
Sbjct: 236 KNPHQWTVSFGTKINPPLMKRNVRRFIIHEKYRSAAREYDIAVVQVSSRVTFSDDIRQIC 295

Query: 298 LPDASYEFQPGDVMFVTGFGALKNDGYSQNHLRQAQVTLIDATTCNEPQAYNDAITPRML 357
           LP+AS  FQP   + +TGFGAL   G SQN LR+A+V +I    C +PQ Y + I P M 
Sbjct: 296 LPEASASFQPNLTVHITGFGALYYGGESQNDLREARVKIISDDVCKQPQVYGNDIKPGMF 355

Query: 358 CAGSLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTRVTALRDWI 417
           CAG +EG  DAC+GDSGGPLV+ D +D WYL GIVSWGD C + +KPGVYT+VT  R+WI
Sbjct: 356 CAGYMEGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKPGVYTQVTYYRNWI 415

Query: 418 TSKTGI 423
            SKTGI
Sbjct: 416 ASKTGI 421


>gi|194018492 transmembrane protease, serine 11F [Homo sapiens]
          Length = 438

 Score =  349 bits (895), Expect = 3e-96
 Identities = 184/421 (43%), Positives = 256/421 (60%), Gaps = 10/421 (2%)

Query: 11  RKRVCWEPWVIGLVIFISLIVLAVCIGLTVHYVRYNQKKTYNYYSTLSFTTDKLYAEFGR 70
           RK+  W+   + L     + ++ + IG+  H+V  + K  Y Y ++   T  K    +G 
Sbjct: 20  RKQQFWDSVRLALFTLAIVAIIGIAIGIVTHFVVEDDKSFY-YLASFKVTNIKYKENYGI 78

Query: 71  EASNNFTEMSQRLESMVKNAFYKSPLREEFVKSQVIKFSQQKHGVLAHMLLICRFHSTED 130
            +S  F E S ++E M+   F  S +   F+KS VIK S  + GV   ++LI R+ ST+ 
Sbjct: 79  RSSREFIERSHQIERMMSRIFRHSSVGGRFIKSHVIKLSPDEQGVDILIVLIFRYPSTDS 138

Query: 131 PETVDKIVQLVLHEKLQDAVGPPKVDPHSVKIKKINKTETDSYLNHCCGTRRSKT----- 185
            E + K ++  L++ L+       ++  S ++  I+  +  + LN  CG R + +     
Sbjct: 139 AEQIKKKIEKALYQSLKTKQLSLTINKPSFRLTPIDSKKMRNLLNSRCGIRMTSSNMPLP 198

Query: 186 -LGQSLRIVGGTEVE-EGEWPWQASLQWDGS-HRCGATLINATWLVSAAHCFTTYKNPAR 242
               + RIV G E   EGEWPWQASLQ  GS H+CGA+LI+ TWL++AAHCF   K+P +
Sbjct: 199 ASSSTQRIVQGRETAMEGEWPWQASLQLIGSGHQCGASLISNTWLLTAAHCFWKNKDPTQ 258

Query: 243 WTASFGVTIKPSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVPYTNAVHRVCLPDAS 302
           W A+FG TI P  +KR +R+II+HE Y   +++ DI+L +LS+ V ++N V RVCLPD+S
Sbjct: 259 WIATFGATITPPAVKRNVRKIILHENYHRETNENDIALVQLSTGVEFSNIVQRVCLPDSS 318

Query: 303 YEFQPGDVMFVTGFGALKNDGYSQNHLRQAQVTLIDATTCNEPQAYNDAITPRMLCAGSL 362
            +  P   +FVTGFG++ +DG  QN LRQA+V  I    CN    Y+  ITP MLCAG +
Sbjct: 319 IKLPPKTSVFVTGFGSIVDDGPIQNTLRQARVETISTDVCNRKDVYDGLITPGMLCAGFM 378

Query: 363 EGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTRVTALRDWITSKTG 422
           EGK DAC+GDSGGPLV  D  DIWY+ GIVSWG  CA P KPGVYTRVT  RDWI SKTG
Sbjct: 379 EGKIDACKGDSGGPLV-YDNHDIWYIVGIVSWGQSCALPKKPGVYTRVTKYRDWIASKTG 437

Query: 423 I 423
           +
Sbjct: 438 M 438


>gi|4758508 transmembrane protease, serine 11D [Homo sapiens]
          Length = 418

 Score =  330 bits (847), Expect = 1e-90
 Identities = 164/422 (38%), Positives = 252/422 (59%), Gaps = 4/422 (0%)

Query: 2   MYRPDVVRARKRVCWEPWVIGLVIFISLIVLAVCIGLTVHYVRYNQKKTYNYYSTLSFTT 61
           MYRP  V +  R    P+V+  ++   +++LAV I L V+++ ++QK +Y Y S+     
Sbjct: 1   MYRPARVTSTSRFL-NPYVVCFIVVAGVVILAVTIALLVYFLAFDQK-SYFYRSSFQLLN 58

Query: 62  DKLYAEFGREASNNFTEMSQRLESMVKNAFYKSPLREEFVKSQVIKFSQQKHGVLAHMLL 121
            +  ++    A+  +  +S R+ES++   F +S LR +F+++ V K  Q   GV A +++
Sbjct: 59  VEYNSQLNSPATQEYRTLSGRIESLITKTFKESNLRNQFIRAHVAKLRQDGSGVRADVVM 118

Query: 122 ICRFHSTEDPETVDKIVQLVLHEKLQDAVGPPKVDPHSVKIKKINKTETDSYLNHCCGTR 181
             +F    +  ++   ++ VL + L ++ G  +++P S +I  +      ++L + CG  
Sbjct: 119 KFQFTRNNNGASMKSRIESVLRQMLNNS-GNLEINP-STEITSLTDQAAANWLINECGAG 176

Query: 182 RSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFTTYKNPA 241
                    RI+GGTE EEG WPWQ SL+ + +H CG +LIN  W+++AAHCF +  NP 
Sbjct: 177 PDLITLSEQRILGGTEAEEGSWPWQVSLRLNNAHHCGGSLINNMWILTAAHCFRSNSNPR 236

Query: 242 RWTASFGVTIKPSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVPYTNAVHRVCLPDA 301
            W A+ G++    K++  +R I++H  YK  +H+ DI+L  L + V +T  +H VCLP A
Sbjct: 237 DWIATSGISTTFPKLRMRVRNILIHNNYKSATHENDIALVRLENSVTFTKDIHSVCLPAA 296

Query: 302 SYEFQPGDVMFVTGFGALKNDGYSQNHLRQAQVTLIDATTCNEPQAYNDAITPRMLCAGS 361
           +    PG   +VTG+GA +  G++   LRQ QV +I    CN P +YN AI   MLCAG 
Sbjct: 297 TQNIPPGSTAYVTGWGAQEYAGHTVPELRQGQVRIISNDVCNAPHSYNGAILSGMLCAGV 356

Query: 362 LEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTRVTALRDWITSKT 421
            +G  DACQGDSGGPLV  D+R +W++ GIVSWGD+C  P+KPGVYTRVTA  DWI  +T
Sbjct: 357 PQGGVDACQGDSGGPLVQEDSRRLWFIVGIVSWGDQCGLPDKPGVYTRVTAYLDWIRQQT 416

Query: 422 GI 423
           GI
Sbjct: 417 GI 418


>gi|187761337 transmembrane protease, serine 11B [Homo sapiens]
          Length = 416

 Score =  314 bits (805), Expect = 8e-86
 Identities = 165/422 (39%), Positives = 237/422 (56%), Gaps = 6/422 (1%)

Query: 2   MYRPDVVRARKRVCWEPWVIGLVIFISLIVLAVCIGLTVHYVRYNQKKTYNYYSTLSFTT 61
           MYR  +   R    W  W    +      +L V IGL VH++    +KTY Y      + 
Sbjct: 1   MYRHGISSQRS---WPLWTTIFIFLGVAAILGVTIGLLVHFLAV--EKTYYYQGDFHISG 55

Query: 62  DKLYAEFGREASNNFTEMSQRLESMVKNAFYKSPLREEFVKSQVIKFSQQKHGVLAHMLL 121
                     AS   T +S+ +E+ + NAF  S + +E+VKS+VIK     +G    + L
Sbjct: 56  VTYNDNCENAASQASTNLSKDIETKMLNAFQNSSIYKEYVKSEVIKLLPNANGSNVQLQL 115

Query: 122 ICRFHSTEDPETVDKIVQLVLHEKLQDAVGPPKVDPHSVKIKKINKTETDSYLNHCCGTR 181
             +F   E      KI +  LH+ L++ +      P S+K+ +I+K  ++   N+CCG +
Sbjct: 116 KFKFPPAEGVSMRTKI-KAKLHQMLKNNMASWNAVPASIKLMEISKAASEMLTNNCCGRQ 174

Query: 182 RSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFTTYKNPA 241
            + ++    +IV G    EG WPWQAS+QW G H CGA+LI++ WL+SAAHCF    N  
Sbjct: 175 VANSIITGNKIVNGKSSLEGAWPWQASMQWKGRHYCGASLISSRWLLSAAHCFAKKNNSK 234

Query: 242 RWTASFGVTIKPSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVPYTNAVHRVCLPDA 301
            WT +FG+ +    M R ++ II HE Y  P    DI+L +L+  V +T  + ++CLP+A
Sbjct: 235 DWTVNFGIVVNKPYMTRKVQNIIFHENYSSPGLHDDIALVQLAEEVSFTEYIRKICLPEA 294

Query: 302 SYEFQPGDVMFVTGFGALKNDGYSQNHLRQAQVTLIDATTCNEPQAYNDAITPRMLCAGS 361
             +    D + VTG+G L  +G     L++  + +ID   CN   AY+  +T  MLCAG 
Sbjct: 295 KMKLSENDNVVVTGWGTLYMNGSFPVILQEDFLKIIDNKICNASYAYSGFVTDTMLCAGF 354

Query: 362 LEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTRVTALRDWITSKT 421
           + G+ DACQ DSGGPL   D+R+IW+L GIVSWGD C K NKPGVYTRVT+ R+WITSKT
Sbjct: 355 MSGEADACQNDSGGPLAYPDSRNIWHLVGIVSWGDGCGKKNKPGVYTRVTSYRNWITSKT 414

Query: 422 GI 423
           G+
Sbjct: 415 GL 416


>gi|11415040 matriptase [Homo sapiens]
          Length = 855

 Score =  224 bits (572), Expect = 9e-59
 Identities = 119/259 (45%), Positives = 158/259 (61%), Gaps = 20/259 (7%)

Query: 178 CGTRRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGS-HRCGATLINATWLVSAAHCFTT 236
           CG R   +  +  R+VGGT+ +EGEWPWQ SL   G  H CGA+LI+  WLVSAAHC+  
Sbjct: 604 CGLR---SFTRQARVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVSAAHCYID 660

Query: 237 -----YKNPARWTASFGVTIK-----PSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSP 286
                Y +P +WTA  G+  +     P   +R L+RII H  +   + DYDI+L EL  P
Sbjct: 661 DRGFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIALLELEKP 720

Query: 287 VPYTNAVHRVCLPDASYEFQPGDVMFVTGFGALKNDGYSQNHLRQAQVTLIDATTCNE-- 344
             Y++ V  +CLPDAS+ F  G  ++VTG+G  +  G     L++ ++ +I+ TTC    
Sbjct: 721 AEYSSMVRPICLPDASHVFPAGKAIWVTGWGHTQYGGTGALILQKGEIRVINQTTCENLL 780

Query: 345 PQAYNDAITPRMLCAGSLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKP 404
           PQ     ITPRM+C G L G  D+CQGDSGGPL S +A    + AG+VSWGD CA+ NKP
Sbjct: 781 PQQ----ITPRMMCVGFLSGGVDSCQGDSGGPLSSVEADGRIFQAGVVSWGDGCAQRNKP 836

Query: 405 GVYTRVTALRDWITSKTGI 423
           GVYTR+   RDWI   TG+
Sbjct: 837 GVYTRLPLFRDWIKENTGV 855


>gi|33667063 transmembrane protease, serine 9 [Homo sapiens]
          Length = 1059

 Score =  218 bits (555), Expect = 8e-57
 Identities = 112/252 (44%), Positives = 157/252 (62%), Gaps = 10/252 (3%)

Query: 176 HC-CGTRRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCF 234
           HC CG + +  +    RIVGG E   GE+PWQASL+ +  H CGA +INA WLVSAAHCF
Sbjct: 188 HCECGLQPAWRMAG--RIVGGMEASPGEFPWQASLRENKEHFCGAAIINARWLVSAAHCF 245

Query: 235 TTYKNPARWTASFGVTI----KPSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVPYT 290
             +++P +W A  G T     + S ++  + +I+ H  Y   + D+D+++ EL+SP+P+ 
Sbjct: 246 NEFQDPTKWVAYVGATYLSGSEASTVRAQVVQIVKHPLYNADTADFDVAVLELTSPLPFG 305

Query: 291 NAVHRVCLPDASYEFQPGDVMFVTGFGALKNDGYSQNH-LRQAQVTLIDATTCNEPQAYN 349
             +  VCLP A++ F P     ++G+G LK D   +   L++A V L+D   C     Y 
Sbjct: 306 RHIQPVCLPAATHIFPPSKKCLISGWGYLKEDFLVKPEVLQKATVELLDQALC--ASLYG 363

Query: 350 DAITPRMLCAGSLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTR 409
            ++T RM+CAG L+GK D+CQGDSGGPLV  +    ++LAGIVSWG  CA+  +PGVY R
Sbjct: 364 HSLTDRMVCAGYLDGKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWGIGCAEARRPGVYAR 423

Query: 410 VTALRDWITSKT 421
           VT LRDWI   T
Sbjct: 424 VTRLRDWILEAT 435



 Score =  196 bits (497), Expect = 4e-50
 Identities = 107/245 (43%), Positives = 148/245 (60%), Gaps = 10/245 (4%)

Query: 178 CGTRRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFTTY 237
           CG R +  + +  R+VGG     GE PWQ SL+    H CGAT++   WL+SAAHCF   
Sbjct: 492 CGARPA--MEKPTRVVGGFGAASGEVPWQVSLKEGSRHFCGATVVGDRWLLSAAHCFNHT 549

Query: 238 K----NPARWTASFGVTIKPSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVPYTNAV 293
           K         TAS  + +  S +K GLRR+++H  Y     D+D+++ EL+SP+ +   +
Sbjct: 550 KVEQVRAHLGTASL-LGLGGSPVKIGLRRVVLHPLYNPGILDFDLAVLELASPLAFNKYI 608

Query: 294 HRVCLPDASYEFQPGDVMFVTGFGALKNDGYSQNHLRQ-AQVTLIDATTCNEPQAYNDAI 352
             VCLP A  +F  G    ++G+G  +    ++  L Q A V +ID  TC+    YN ++
Sbjct: 609 QPVCLPLAIQKFPVGRKCMISGWGNTQEGNATKPELLQKASVGIIDQKTCSV--LYNFSL 666

Query: 353 TPRMLCAGSLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTRVTA 412
           T RM+CAG LEGK D+CQGDSGGPL   +A  ++YLAGIVSWG  CA+  KPGVYTR+T 
Sbjct: 667 TDRMICAGFLEGKVDSCQGDSGGPLACEEAPGVFYLAGIVSWGIGCAQVKKPGVYTRITR 726

Query: 413 LRDWI 417
           L+ WI
Sbjct: 727 LKGWI 731



 Score =  185 bits (469), Expect = 8e-47
 Identities = 99/234 (42%), Positives = 132/234 (56%), Gaps = 13/234 (5%)

Query: 191  RIVGGTEVEEGEWPWQASLQW--DGSHRCGATLINATWLVSAAHCFTTYKNPARWTASFG 248
            RIVGG+    GEWPWQ SL W     HRCGA L+   WL+SAAHCF  Y +P +W A  G
Sbjct: 826  RIVGGSAAGRGEWPWQVSL-WLRRREHRCGAVLVAERWLLSAAHCFDVYGDPKQWAAFLG 884

Query: 249  VTIKPSKMKRGLRRIIVHEKYKHPSH-----DYDISLAELSSPVPYTNAVHRVCLPDASY 303
                 S  +  L R+     YKHP +     DYD++L EL+ PV  +  V  +CLP+ + 
Sbjct: 885  TPFL-SGAEGQLERVA--RIYKHPFYNLYTLDYDVALLELAGPVRRSRLVRPICLPEPAP 941

Query: 304  EFQPGDVMFVTGFGALKNDGYSQNHLRQAQVTLIDATTCNEPQAYNDAITPRMLCAGSLE 363
                G    +TG+G+++  G     L++A V L+   TC   + Y   I+ RMLCAG  +
Sbjct: 942  RPPDGTRCVITGWGSVREGGSMARQLQKAAVRLLSEQTCR--RFYPVQISSRMLCAGFPQ 999

Query: 364  GKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTRVTALRDWI 417
            G  D+C GD+GGPL   +    W L G+ SWG  C +P+ PGVYTRV A+R WI
Sbjct: 1000 GGVDSCSGDAGGPLACREPSGRWVLTGVTSWGYGCGRPHFPGVYTRVAAVRGWI 1053


>gi|23957702 transmembrane protease, serine 6 [Homo sapiens]
          Length = 811

 Score =  215 bits (548), Expect = 5e-56
 Identities = 114/249 (45%), Positives = 149/249 (59%), Gaps = 14/249 (5%)

Query: 176 HC-CGTRRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCF 234
           HC CG +     G S RIVGG    EGEWPWQASLQ  G H CG  LI   W+++AAHCF
Sbjct: 565 HCDCGLQ-----GPSSRIVGGAVSSEGEWPWQASLQVRGRHICGGALIADRWVITAAHCF 619

Query: 235 T--TYKNPARWTASFGVTIK----PSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVP 288
              +  +   WT   G   +    P ++   + R+++H  ++  SHDYD++L +L  PV 
Sbjct: 620 QEDSMASTVLWTVFLGKVWQNSRWPGEVSFKVSRLLLHPYHEEDSHDYDVALLQLDHPVV 679

Query: 289 YTNAVHRVCLPDASYEFQPGDVMFVTGFGALKNDGYSQNHLRQAQVTLIDATTCNEPQAY 348
            + AV  VCLP  S+ F+PG   ++TG+GAL+  G   N L++  V LI    C+E   Y
Sbjct: 680 RSAAVRPVCLPARSHFFEPGLHCWITGWGALREGGPISNALQKVDVQLIPQDLCSEVYRY 739

Query: 349 NDAITPRMLCAGSLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYT 408
              +TPRMLCAG  +GK DACQGDSGGPLV       W+LAG+VSWG  C +PN  GVYT
Sbjct: 740 Q--VTPRMLCAGYRKGKKDACQGDSGGPLVCKALSGRWFLAGLVSWGLGCGRPNYFGVYT 797

Query: 409 RVTALRDWI 417
           R+T +  WI
Sbjct: 798 RITGVISWI 806


>gi|116256363 transmembrane protease, serine 13 [Homo sapiens]
          Length = 567

 Score =  199 bits (507), Expect = 3e-51
 Identities = 109/275 (39%), Positives = 150/275 (54%), Gaps = 13/275 (4%)

Query: 158 HSVKIKKINKTETDSYLNHCCGTRRSKTL--------GQSLRIVGGTEVEEGEWPWQASL 209
           +S  I + N T  +S     C ++R  +L          + RIVGG    + +WPWQ SL
Sbjct: 284 NSFSILRYNSTIQESLHRSECPSQRYISLQCSHCGLRAMTGRIVGGALASDSKWPWQVSL 343

Query: 210 QWDGSHRCGATLINATWLVSAAHCF--TTYKNPARWTASFGVT-IKPSKMKRGLRRIIVH 266
            +  +H CG TLI+A W+++AAHCF  T  K    W    G + +        +  II++
Sbjct: 344 HFGTTHICGGTLIDAQWVLTAAHCFFVTREKVLEGWKVYAGTSNLHQLPEAASIAEIIIN 403

Query: 267 EKYKHPSHDYDISLAELSSPVPYTNAVHRVCLPDASYEFQPGDVMFVTGFGALKN-DGYS 325
             Y     DYDI+L  LS P+  +  +H  CLP     F   +  ++TGFG  +  D  +
Sbjct: 404 SNYTDEEDDYDIALMRLSKPLTLSAHIHPACLPMHGQTFSLNETCWITGFGKTRETDDKT 463

Query: 326 QNHLRQAQVTLIDATTCNEPQAYNDAITPRMLCAGSLEGKTDACQGDSGGPLVSSDARDI 385
              LR+ QV LID   CN+   Y+  +TPRM+CAG L G  D+CQGDSGGPLV  +  + 
Sbjct: 464 SPFLREVQVNLIDFKKCNDYLVYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLV-CEQNNR 522

Query: 386 WYLAGIVSWGDECAKPNKPGVYTRVTALRDWITSK 420
           WYLAG+ SWG  C + NKPGVYT+VT +  WI SK
Sbjct: 523 WYLAGVTSWGTGCGQRNKPGVYTKVTEVLPWIYSK 557


>gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo
           sapiens]
          Length = 454

 Score =  193 bits (491), Expect = 2e-49
 Identities = 105/246 (42%), Positives = 138/246 (56%), Gaps = 14/246 (5%)

Query: 178 CGTRRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFTTY 237
           CG RR    G S RIVGG      +WPWQASLQ+ G H CG ++I   W+++AAHC    
Sbjct: 207 CGHRR----GYSSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDL 262

Query: 238 KNPARWTASFGVTI-----KPSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVPYTNA 292
             P  WT   G+        PS +   + +I+ H KYK      DI+L +L+ P+ +   
Sbjct: 263 YLPKSWTIQVGLVSLLDNPAPSHL---VEKIVYHSKYKPKRLGNDIALMKLAGPLTFNEM 319

Query: 293 VHRVCLPDASYEFQPGDVMFVTGFGALKND-GYSQNHLRQAQVTLIDATTCNEPQAYNDA 351
           +  VCLP++   F  G V + +G+GA ++  G +   L  A V LI    CN    Y   
Sbjct: 320 IQPVCLPNSEENFPDGKVCWTSGWGATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGI 379

Query: 352 ITPRMLCAGSLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTRVT 411
           I+P MLCAG L G  D+CQGDSGGPLV  + R +W L G  S+G  CA+ NKPGVYTRVT
Sbjct: 380 ISPSMLCAGYLTGGVDSCQGDSGGPLVCQERR-LWKLVGATSFGIGCAEVNKPGVYTRVT 438

Query: 412 ALRDWI 417
           +  DWI
Sbjct: 439 SFLDWI 444


>gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo
           sapiens]
          Length = 529

 Score =  191 bits (486), Expect = 8e-49
 Identities = 99/245 (40%), Positives = 138/245 (56%), Gaps = 9/245 (3%)

Query: 178 CGTRRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFTT- 236
           CG   + +  +  RIVGG     G WPWQ SL     H CG ++I   W+V+AAHC    
Sbjct: 281 CGVNLNSS--RQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKP 338

Query: 237 YKNPARWTASFGVTIKPSKMKRG----LRRIIVHEKYKHPSHDYDISLAELSSPVPYTNA 292
             NP  WTA  G+ ++ S M  G    + ++I H  Y   + + DI+L +L  P+ + + 
Sbjct: 339 LNNPWHWTAFAGI-LRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDL 397

Query: 293 VHRVCLPDASYEFQPGDVMFVTGFGALKNDGYSQNHLRQAQVTLIDATTCNEPQAYNDAI 352
           V  VCLP+     QP  + +++G+GA +  G +   L  A+V LI+   CN    Y++ I
Sbjct: 398 VKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLI 457

Query: 353 TPRMLCAGSLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTRVTA 412
           TP M+CAG L+G  D+CQGDSGGPLV+S   +IW+L G  SWG  CAK  +PGVY  V  
Sbjct: 458 TPAMICAGFLQGNVDSCQGDSGGPLVTS-KNNIWWLIGDTSWGSGCAKAYRPGVYGNVMV 516

Query: 413 LRDWI 417
             DWI
Sbjct: 517 FTDWI 521


>gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo
           sapiens]
          Length = 492

 Score =  191 bits (486), Expect = 8e-49
 Identities = 99/245 (40%), Positives = 138/245 (56%), Gaps = 9/245 (3%)

Query: 178 CGTRRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFTT- 236
           CG   + +  +  RIVGG     G WPWQ SL     H CG ++I   W+V+AAHC    
Sbjct: 244 CGVNLNSS--RQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKP 301

Query: 237 YKNPARWTASFGVTIKPSKMKRG----LRRIIVHEKYKHPSHDYDISLAELSSPVPYTNA 292
             NP  WTA  G+ ++ S M  G    + ++I H  Y   + + DI+L +L  P+ + + 
Sbjct: 302 LNNPWHWTAFAGI-LRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDL 360

Query: 293 VHRVCLPDASYEFQPGDVMFVTGFGALKNDGYSQNHLRQAQVTLIDATTCNEPQAYNDAI 352
           V  VCLP+     QP  + +++G+GA +  G +   L  A+V LI+   CN    Y++ I
Sbjct: 361 VKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLI 420

Query: 353 TPRMLCAGSLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTRVTA 412
           TP M+CAG L+G  D+CQGDSGGPLV+S   +IW+L G  SWG  CAK  +PGVY  V  
Sbjct: 421 TPAMICAGFLQGNVDSCQGDSGGPLVTS-KNNIWWLIGDTSWGSGCAKAYRPGVYGNVMV 479

Query: 413 LRDWI 417
             DWI
Sbjct: 480 FTDWI 484


>gi|170932492 transmembrane protease, serine 5 [Homo sapiens]
          Length = 457

 Score =  191 bits (484), Expect = 1e-48
 Identities = 98/234 (41%), Positives = 134/234 (57%), Gaps = 9/234 (3%)

Query: 191 RIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFTTYK--NPARWTASFG 248
           RIVGG  V  G WPWQAS+     H CG +++   W+V+AAHC  +++    + W    G
Sbjct: 217 RIVGGQSVAPGRWPWQASVALGFRHTCGGSVLAPRWVVTAAHCMHSFRLARLSSWRVHAG 276

Query: 249 VT----IKPSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVPYTNAVHRVCLPDASYE 304
           +     ++P +    + RII H  Y   +HDYD++L  L + + +++ V  VCLP     
Sbjct: 277 LVSHSAVRPHQGAL-VERIIPHPLYSAQNHDYDVALLRLQTALNFSDTVGAVCLPAKEQH 335

Query: 305 FQPGDVMFVTGFGALK-NDGYSQNHLRQAQVTLIDATTCNEPQAYNDAITPRMLCAGSLE 363
           F  G   +V+G+G    +  YS + L+   V L     CN    Y+ A+TPRMLCAG L+
Sbjct: 336 FPKGSRCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVYSGALTPRMLCAGYLD 395

Query: 364 GKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTRVTALRDWI 417
           G+ DACQGDSGGPLV  D  D W L G+VSWG  CA+PN PGVY +V    DWI
Sbjct: 396 GRADACQGDSGGPLVCPDG-DTWRLVGVVSWGRGCAEPNHPGVYAKVAEFLDWI 448


>gi|222831592 transmembrane protease, serine 7 [Homo sapiens]
          Length = 717

 Score =  190 bits (483), Expect = 2e-48
 Identities = 110/248 (44%), Positives = 142/248 (57%), Gaps = 13/248 (5%)

Query: 177 CCGTRRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCF-- 234
           C  +R S  L    RI+GGT+  EG WPWQ SL + GS  CGA++I+  WL+SAAHCF  
Sbjct: 468 CTCSRSSSALH---RIIGGTDTLEGGWPWQVSLHFVGSAYCGASVISREWLLSAAHCFHG 524

Query: 235 TTYKNPARWTASFGVTIK-PSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVPYT--N 291
               +P  WTA  G+ ++  +K    +RRI+VHE Y   + DYDI+L +LS   P T   
Sbjct: 525 NRLSDPTPWTAHLGMYVQGNAKFVSPVRRIVVHEYYNSQTFDYDIALLQLSIAWPETLKQ 584

Query: 292 AVHRVCLPDASYEFQPGDVMFVTGFGAL-KNDGYSQNHLRQAQVTLIDATTCNEPQAYND 350
            +  +C+P      + G+  +VTG+G   + D      L+QA+V LID T C        
Sbjct: 585 LIQPICIPPTGQRVRSGEKCWVTGWGRRHEADNKGSLVLQQAEVELIDQTLCVSTYG--- 641

Query: 351 AITPRMLCAGSLEGKTDACQGDSGGPLVSSDARD-IWYLAGIVSWGDECAKPNKPGVYTR 409
            IT RMLCAG + GK DAC+GDSGGPL      D  W L GIVSWG    +PN PGVYTR
Sbjct: 642 IITSRMLCAGIMSGKRDACKGDSGGPLSCRRKSDGKWILTGIVSWGHGSGRPNFPGVYTR 701

Query: 410 VTALRDWI 417
           V+    WI
Sbjct: 702 VSNFVPWI 709


>gi|33695155 hepsin [Homo sapiens]
          Length = 417

 Score =  190 bits (482), Expect = 2e-48
 Identities = 98/239 (41%), Positives = 133/239 (55%), Gaps = 12/239 (5%)

Query: 191 RIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFTTYKNP-ARWTASFGV 249
           RIVGG +   G WPWQ SL++DG+H CG +L++  W+++AAHCF       +RW    G 
Sbjct: 162 RIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGA 221

Query: 250 TIK--PSKMKRGLRRIIVHEKY------KHPSHDYDISLAELSSPVPYTNAVHRVCLPDA 301
             +  P  ++ G++ ++ H  Y          +  DI+L  LSSP+P T  +  VCLP A
Sbjct: 222 VAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAA 281

Query: 302 SYEFQPGDVMFVTGFGALKNDGYSQNHLRQAQVTLIDATTCNEPQAYNDAITPRMLCAGS 361
                 G +  VTG+G  +  G     L++A+V +I    CN    Y + I P+M CAG 
Sbjct: 282 GQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGY 341

Query: 362 LEGKTDACQGDSGGPLVSSDA---RDIWYLAGIVSWGDECAKPNKPGVYTRVTALRDWI 417
            EG  DACQGDSGGP V  D+      W L GIVSWG  CA   KPGVYT+V+  R+WI
Sbjct: 342 PEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWI 400


>gi|4504481 hepsin [Homo sapiens]
          Length = 417

 Score =  190 bits (482), Expect = 2e-48
 Identities = 98/239 (41%), Positives = 133/239 (55%), Gaps = 12/239 (5%)

Query: 191 RIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFTTYKNP-ARWTASFGV 249
           RIVGG +   G WPWQ SL++DG+H CG +L++  W+++AAHCF       +RW    G 
Sbjct: 162 RIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGA 221

Query: 250 TIK--PSKMKRGLRRIIVHEKY------KHPSHDYDISLAELSSPVPYTNAVHRVCLPDA 301
             +  P  ++ G++ ++ H  Y          +  DI+L  LSSP+P T  +  VCLP A
Sbjct: 222 VAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAA 281

Query: 302 SYEFQPGDVMFVTGFGALKNDGYSQNHLRQAQVTLIDATTCNEPQAYNDAITPRMLCAGS 361
                 G +  VTG+G  +  G     L++A+V +I    CN    Y + I P+M CAG 
Sbjct: 282 GQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGY 341

Query: 362 LEGKTDACQGDSGGPLVSSDA---RDIWYLAGIVSWGDECAKPNKPGVYTRVTALRDWI 417
            EG  DACQGDSGGP V  D+      W L GIVSWG  CA   KPGVYT+V+  R+WI
Sbjct: 342 PEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWI 400


>gi|110815798 ovochymase 1 [Homo sapiens]
          Length = 1134

 Score =  187 bits (475), Expect = 2e-47
 Identities = 105/275 (38%), Positives = 148/275 (53%), Gaps = 12/275 (4%)

Query: 153 PKVDPHSVKIKKINKTETDSYLNHCCGTRRSKTLGQSLRIVGGTEVEEGEWPWQASLQWD 212
           PK+ P +  +  +      + L+  CG         S RI GG E     WPWQ  L++ 
Sbjct: 541 PKLPPQNNPVSTVK-----AILHDVCGIPPFSPQWLSRRIAGGEEACPHCWPWQVGLRFL 595

Query: 213 GSHRCGATLINATWLVSAAHCFTTYKNPARWTASFGV---TIKPS-KMKRGLRRIIVHEK 268
           G ++CG  +IN  W+++AAHC     NP  WT   G     +K S +  R  + IIVHE 
Sbjct: 596 GDYQCGGAIINPVWILTAAHCVQLKNNPLSWTIIAGDHDRNLKESTEQVRRAKHIIVHED 655

Query: 269 YKHPSHDYDISLAELSSPVPYTNAVHRVCLPDASYEFQPGDVMFVTGFGALKNDGYSQNH 328
           +   S+D DI+L +LSSP+ Y + V  VCLP ++      ++  VTG+G++  DG   + 
Sbjct: 656 FNTLSYDSDIALIQLSSPLEYNSVVRPVCLPHSAEPLFSSEICAVTGWGSISADGGLASR 715

Query: 329 LRQAQVTLIDATTCNEP--QAYNDAITPRMLCAG-SLEGKTDACQGDSGGPLVSSDARDI 385
           L+Q QV +++   C      A+   IT +M+CAG +  G+ D CQGDSGGPLV       
Sbjct: 716 LQQIQVHVLEREVCEHTYYSAHPGGITEKMICAGFAASGEKDFCQGDSGGPLVCRHENGP 775

Query: 386 WYLAGIVSWGDECAKPNKPGVYTRVTALRDWITSK 420
           + L GIVSWG  C +P KPGV+ RV    DWI SK
Sbjct: 776 FVLYGIVSWGAGCVQPWKPGVFARVMIFLDWIQSK 810



 Score =  124 bits (310), Expect = 2e-28
 Identities = 81/236 (34%), Positives = 122/236 (51%), Gaps = 23/236 (9%)

Query: 204 PWQASLQWDGSHRCGATLINATWLVSAAHCFTTY-----KNPARWTASFGVTIKPSKMKR 258
           PWQ SL+ D  H CG +LI    +V+AAHC  +      KN    +  + +  K  + + 
Sbjct: 59  PWQVSLKSDEHHFCGGSLIQEDRVVTAAHCLDSLSEKQLKNITVTSGEYSLFQKDKQEQN 118

Query: 259 -GLRRIIVHEKYKHPSHDY---DISLAELSSPVPYTNAVHRVCLPDASYEFQPGDVMFVT 314
             + +II H +Y   S +Y   DI+L  L   V + NAV  +CLPD+  + +PG +   +
Sbjct: 119 IPVSKIITHPEYN--SREYMSPDIALLYLKHKVKFGNAVQPICLPDSDDKVEPGILCLSS 176

Query: 315 GFGALKNDGYSQNHLRQAQVTLIDATTCNEP-QAYN-DAITPRMLCAGSLEGKTDACQGD 372
           G+G +       N L++ ++ ++D   CN   ++ N   +   MLCAG  +   DACQGD
Sbjct: 177 GWGKISKTSEYSNVLQEMELPIMDDRACNTVLKSMNLPPLGRTMLCAGFPDWGMDACQGD 236

Query: 373 SGGPLVSSDARDIWYLAGIVSWGDECAKPNKP----------GVYTRVTALRDWIT 418
           SGGPLV      IW LAGI SW   CA  + P          G++++V+ L D+IT
Sbjct: 237 SGGPLVCRRGGGIWILAGITSWVAGCAGGSVPVRNNHVKASLGIFSKVSELMDFIT 292


>gi|223942069 enterokinase precursor [Homo sapiens]
          Length = 1019

 Score =  184 bits (466), Expect = 2e-46
 Identities = 94/236 (39%), Positives = 139/236 (58%), Gaps = 10/236 (4%)

Query: 191  RIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHC-FTTYKNPARWTASFGV 249
            +IVGG+  +EG WPW   L + G   CGA+L+++ WLVSAAHC +     P++WTA  G+
Sbjct: 784  KIVGGSNAKEGAWPWVVGLYYGGRLLCGASLVSSDWLVSAAHCVYGRNLEPSKWTAILGL 843

Query: 250  TIK-----PSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVPYTNAVHRVCLPDASYE 304
             +K     P  + R +  I+++  Y     D DI++  L   V YT+ +  +CLP+ +  
Sbjct: 844  HMKSNLTSPQTVPRLIDEIVINPHYNRRRKDNDIAMMHLEFKVNYTDYIQPICLPEENQV 903

Query: 305  FQPGDVMFVTGFGALKNDGYSQNHLRQAQVTLIDATTCNEPQ-AYNDAITPRMLCAGSLE 363
            F PG    + G+G +   G + N L++A V L+    C +    YN  IT  M+CAG  E
Sbjct: 904  FPPGRNCSIAGWGTVVYQGTTANILQEADVPLLSNERCQQQMPEYN--ITENMICAGYEE 961

Query: 364  GKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTRVTALRDWITS 419
            G  D+CQGDSGGPL+  +  + W+LAG+ S+G +CA PN+PGVY RV+   +WI S
Sbjct: 962  GGIDSCQGDSGGPLMCQE-NNRWFLAGVTSFGYKCALPNRPGVYARVSRFTEWIQS 1016


>gi|145701030 transmembrane protease, serine 4 isoform 3 [Homo
           sapiens]
          Length = 432

 Score =  184 bits (466), Expect = 2e-46
 Identities = 94/243 (38%), Positives = 135/243 (55%), Gaps = 6/243 (2%)

Query: 176 HCCGTRRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFT 235
           HC    +S    ++ R+VGG E     WPWQ S+Q+D  H CG ++++  W+++AAHCF 
Sbjct: 187 HCLACGKSL---KTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFR 243

Query: 236 TYKNPARWTASFGVTIKPSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVPYTNAVHR 295
            + +   W    G     S     + +II+ E       D DI+L +L  P+ ++  V  
Sbjct: 244 KHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVRP 303

Query: 296 VCLPDASYEFQPGDVMFVTGFGALK-NDGYSQNHLRQAQVTLIDATTCNEPQAYNDAITP 354
           +CLP    E  P   +++ G+G  K N G   + L QA V +ID+T CN   AY   +T 
Sbjct: 304 ICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTE 363

Query: 355 RMLCAGSLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTRVTALR 414
           +M+CAG  EG  D CQGDSGGPL+     D W++ GIVSWG  C  P+ PGVYT+V+A  
Sbjct: 364 KMMCAGIPEGGVDTCQGDSGGPLMYQS--DQWHVVGIVSWGYGCGGPSTPGVYTKVSAYL 421

Query: 415 DWI 417
           +WI
Sbjct: 422 NWI 424


>gi|15451940 transmembrane protease, serine 4 isoform 1 [Homo
           sapiens]
          Length = 437

 Score =  184 bits (466), Expect = 2e-46
 Identities = 94/243 (38%), Positives = 135/243 (55%), Gaps = 6/243 (2%)

Query: 176 HCCGTRRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFT 235
           HC    +S    ++ R+VGG E     WPWQ S+Q+D  H CG ++++  W+++AAHCF 
Sbjct: 192 HCLACGKSL---KTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFR 248

Query: 236 TYKNPARWTASFGVTIKPSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVPYTNAVHR 295
            + +   W    G     S     + +II+ E       D DI+L +L  P+ ++  V  
Sbjct: 249 KHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVRP 308

Query: 296 VCLPDASYEFQPGDVMFVTGFGALK-NDGYSQNHLRQAQVTLIDATTCNEPQAYNDAITP 354
           +CLP    E  P   +++ G+G  K N G   + L QA V +ID+T CN   AY   +T 
Sbjct: 309 ICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTE 368

Query: 355 RMLCAGSLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTRVTALR 414
           +M+CAG  EG  D CQGDSGGPL+     D W++ GIVSWG  C  P+ PGVYT+V+A  
Sbjct: 369 KMMCAGIPEGGVDTCQGDSGGPLMYQS--DQWHVVGIVSWGYGCGGPSTPGVYTKVSAYL 426

Query: 415 DWI 417
           +WI
Sbjct: 427 NWI 429


>gi|13994276 marapsin [Homo sapiens]
          Length = 290

 Score =  182 bits (461), Expect = 7e-46
 Identities = 103/260 (39%), Positives = 144/260 (55%), Gaps = 20/260 (7%)

Query: 177 CCGTRRSKTLGQS------LRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSA 230
           C G++R+K            R+VGG + +EGEWPWQ S+Q +GSH CG +LI   W+++A
Sbjct: 14  CFGSQRAKAATACGRPRMLNRMVGGQDTQEGEWPWQVSIQRNGSHFCGGSLIAEQWVLTA 73

Query: 231 AHCFTTYKNPARWTASFG----VTIKPSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSP 286
           AHCF      + +    G    V   P  M   +R++  +  Y+  +   D++L EL +P
Sbjct: 74  AHCFRNTSETSLYQVLLGARQLVQPGPHAMYARVRQVESNPLYQGTASSADVALVELEAP 133

Query: 287 VPYTNAVHRVCLPDASYEFQPGDVMFVTGFGALKNDGY--SQNHLRQAQVTLIDATTCN- 343
           VP+TN +  VCLPD S  F+ G   +VTG+G+   +        L++  V +ID   CN 
Sbjct: 134 VPFTNYILPVCLPDPSVIFETGMNCWVTGWGSPSEEDLLPEPRILQKLAVPIIDTPKCNL 193

Query: 344 ------EPQAYNDAITPRMLCAGSLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDE 397
                 E       I   MLCAG  EGK DAC+GDSGGPLV    +  W  AG++SWG+ 
Sbjct: 194 LYSKDTEFGYQPKTIKNDMLCAGFEEGKKDACKGDSGGPLVCLVGQS-WLQAGVISWGEG 252

Query: 398 CAKPNKPGVYTRVTALRDWI 417
           CA+ N+PGVY RVTA  +WI
Sbjct: 253 CARQNRPGVYIRVTAHHNWI 272


>gi|5803197 testisin isoform 1 [Homo sapiens]
          Length = 314

 Score =  179 bits (453), Expect = 6e-45
 Identities = 97/242 (40%), Positives = 142/242 (58%), Gaps = 16/242 (6%)

Query: 191 RIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFTTY---KNPARWTASF 247
           RIVGG + E G WPWQ SL+   SH CG +L++  W ++AAHCF TY    +P+ W   F
Sbjct: 41  RIVGGEDAELGRWPWQGSLRLWDSHVCGVSLLSHRWALTAAHCFETYSDLSDPSGWMVQF 100

Query: 248 G-VTIKPS--KMKRGLRRIIVHEKYKHPSH----DYDISLAELSSPVPYTNAVHRVCLPD 300
           G +T  PS   ++    R  V   Y  P +     YDI+L +LS+PV YT  +  +CL  
Sbjct: 101 GQLTSMPSFWSLQAYYTRYFVSNIYLSPRYLGNSPYDIALVKLSAPVTYTKHIQPICLQA 160

Query: 301 ASYEFQPGDVMFVTGFGALKNDGY--SQNHLRQAQVTLIDATTCNE---PQAYNDAITPR 355
           +++EF+     +VTG+G +K D    S + L++ QV +I+ + CN      ++   I   
Sbjct: 161 STFEFENRTDCWVTGWGYIKEDEALPSPHTLQEVQVAIINNSMCNHLFLKYSFRKDIFGD 220

Query: 356 MLCAGSLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTRVTALRD 415
           M+CAG+ +G  DAC GDSGGPL + +   +WY  G+VSWG  C +PN+PGVYT ++   +
Sbjct: 221 MVCAGNAQGGKDACFGDSGGPL-ACNKNGLWYQIGVVSWGVGCGRPNRPGVYTNISHHFE 279

Query: 416 WI 417
           WI
Sbjct: 280 WI 281


>gi|21614531 testisin isoform 2 [Homo sapiens]
          Length = 312

 Score =  176 bits (447), Expect = 3e-44
 Identities = 96/240 (40%), Positives = 141/240 (58%), Gaps = 14/240 (5%)

Query: 191 RIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCF-TTYKNPARWTASFG- 248
           RIVGG + E G WPWQ SL+   SH CG +L++  W ++AAHCF T   +P+ W   FG 
Sbjct: 41  RIVGGEDAELGRWPWQGSLRLWDSHVCGVSLLSHRWALTAAHCFETDLSDPSGWMVQFGQ 100

Query: 249 VTIKPS--KMKRGLRRIIVHEKYKHPSH----DYDISLAELSSPVPYTNAVHRVCLPDAS 302
           +T  PS   ++    R  V   Y  P +     YDI+L +LS+PV YT  +  +CL  ++
Sbjct: 101 LTSMPSFWSLQAYYTRYFVSNIYLSPRYLGNSPYDIALVKLSAPVTYTKHIQPICLQAST 160

Query: 303 YEFQPGDVMFVTGFGALKNDGY--SQNHLRQAQVTLIDATTCNE---PQAYNDAITPRML 357
           +EF+     +VTG+G +K D    S + L++ QV +I+ + CN      ++   I   M+
Sbjct: 161 FEFENRTDCWVTGWGYIKEDEALPSPHTLQEVQVAIINNSMCNHLFLKYSFRKDIFGDMV 220

Query: 358 CAGSLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTRVTALRDWI 417
           CAG+ +G  DAC GDSGGPL + +   +WY  G+VSWG  C +PN+PGVYT ++   +WI
Sbjct: 221 CAGNAQGGKDACFGDSGGPL-ACNKNGLWYQIGVVSWGVGCGRPNRPGVYTNISHHFEWI 279


>gi|117956391 protease, serine, 33 [Homo sapiens]
          Length = 280

 Score =  173 bits (438), Expect = 3e-43
 Identities = 103/258 (39%), Positives = 136/258 (52%), Gaps = 21/258 (8%)

Query: 181 RRSKTLGQ---SLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFTTY 237
           R+S   GQ   S RIVGG +  +GEWPWQAS+Q  G+H CG +LI   W+++AAHCF   
Sbjct: 23  RKSAACGQPRMSSRIVGGRDGRDGEWPWQASIQHRGAHVCGGSLIAPQWVLTAAHCFPRR 82

Query: 238 KNPARWTASFGV----TIKPSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVPYTNAV 293
             PA +    G     +  P  +   +RR+++   Y       D++L +L  PVP +  V
Sbjct: 83  ALPAEYRVRLGALRLGSTSPRTLSVPVRRVLLPPDYSEDGARGDLALLQLRRPVPLSARV 142

Query: 294 HRVCLPDASYEFQPGDVMFVTGFGALKNDGYSQNHLRQAQ---VTLIDATTC-------- 342
             VCLP       PG    VTG+G+L+  G      R  Q   V L+D+ TC        
Sbjct: 143 QPVCLPVPGARPPPGTPCRVTGWGSLR-PGVPLPEWRPLQGVRVPLLDSRTCDGLYHVGA 201

Query: 343 NEPQAYNDAITPRMLCAGSLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPN 402
           + PQA    + P  LCAG  +G  DACQGDSGGPL    +   W L G+VSWG  CA PN
Sbjct: 202 DVPQA-ERIVLPGSLCAGYPQGHKDACQGDSGGPLTCLQSGS-WVLVGVVSWGKGCALPN 259

Query: 403 KPGVYTRVTALRDWITSK 420
           +PGVYT V     WI ++
Sbjct: 260 RPGVYTSVATYSPWIQAR 277


>gi|205360905 testis-specific serine protease 1 [Homo sapiens]
          Length = 318

 Score =  172 bits (435), Expect = 7e-43
 Identities = 95/253 (37%), Positives = 137/253 (54%), Gaps = 19/253 (7%)

Query: 178 CGTRRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFTTY 237
           CG R    L     + GG E   G WPWQASL+    HRCG +L++  W++SAAHCF  +
Sbjct: 46  CGHREIHAL-----VAGGVESARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKH 100

Query: 238 KNPARWTASFG-VTIKPS--KMKRGLRRIIVHEKYKHPSH----DYDISLAELSSPVPYT 290
             P+ WT   G +T +P+   ++    R  V +   +P        DI+L  L+S V Y 
Sbjct: 101 YYPSEWTVQLGELTSRPTPWNLRAYSSRYKVQDIIVNPDALGVLRNDIALLRLASSVTYN 160

Query: 291 NAVHRVCLPDASYEFQPGDVMFVTGFGALKNDGY---SQNHLRQAQVTLIDATTCN---E 344
             +  +C+  +++ F      +VTG+G +   G       +LR+AQVT+++ T CN   E
Sbjct: 161 AYIQPICIESSTFNFVHRPDCWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYLFE 220

Query: 345 PQAYNDAITPRMLCAGSLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKP 404
             +    I   M CAG+ +G  D C+GDSGGPLV  D   +WY  GIVSWG +C +PN+P
Sbjct: 221 QPSSRSMIWDSMFCAGAEDGSVDTCKGDSGGPLV-CDKDGLWYQVGIVSWGMDCGQPNRP 279

Query: 405 GVYTRVTALRDWI 417
           GVYT ++    WI
Sbjct: 280 GVYTNISVYFHWI 292


>gi|78191798 plasma kallikrein B1 precursor [Homo sapiens]
          Length = 638

 Score =  171 bits (434), Expect = 9e-43
 Identities = 99/245 (40%), Positives = 130/245 (53%), Gaps = 11/245 (4%)

Query: 185 TLGQSLRIVGGTEVEEGEWPWQASLQWDGS---HRCGATLINATWLVSAAHCFTTYKNPA 241
           T   S RIVGGT    GEWPWQ SLQ   +   H CG +LI   W+++AAHCF       
Sbjct: 384 TTKTSTRIVGGTNSSWGEWPWQVSLQVKLTAQRHLCGGSLIGHQWVLTAAHCFDGLPLQD 443

Query: 242 RWTASFGVT----IKPSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVPYTNAVHRVC 297
            W    G+     I        ++ II+H+ YK    ++DI+L +L +P+ YT     +C
Sbjct: 444 VWRIYSGILNLSDITKDTPFSQIKEIIIHQNYKVSEGNHDIALIKLQAPLNYTEFQKPIC 503

Query: 298 LPDASYEFQPGDVMFVTGFGALKNDGYSQNHLRQAQVTLIDATTCNEPQAYND-AITPRM 356
           LP            +VTG+G  K  G  QN L++  + L+    C +   Y D  IT RM
Sbjct: 504 LPSKGDTSTIYTNCWVTGWGFSKEKGEIQNILQKVNIPLVTNEECQK--RYQDYKITQRM 561

Query: 357 LCAGSLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTRVTALRDW 416
           +CAG  EG  DAC+GDSGGPLV      +W L GI SWG+ CA+  +PGVYT+V    DW
Sbjct: 562 VCAGYKEGGKDACKGDSGGPLVCKH-NGMWRLVGITSWGEGCARREQPGVYTKVAEYMDW 620

Query: 417 ITSKT 421
           I  KT
Sbjct: 621 ILEKT 625


>gi|4503627 coagulation factor XI precursor [Homo sapiens]
          Length = 625

 Score =  171 bits (434), Expect = 9e-43
 Identities = 94/238 (39%), Positives = 132/238 (55%), Gaps = 9/238 (3%)

Query: 191 RIVGGTEVEEGEWPWQASLQWDGS---HRCGATLINATWLVSAAHCFTTYKNPARWTASF 247
           RIVGGT    GEWPWQ +L        H CG ++I   W+++AAHCF   ++P       
Sbjct: 387 RIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVESPKILRVYS 446

Query: 248 GVT----IKPSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVPYTNAVHRVCLPDASY 303
           G+     IK      G++ II+H++YK     YDI+L +L + V YT++   +CLP    
Sbjct: 447 GILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRPICLPSKGD 506

Query: 304 EFQPGDVMFVTGFGALKNDGYSQNHLRQAQVTLIDATTCNEPQAYNDAITPRMLCAGSLE 363
                   +VTG+G  K     QN L++A++ L+    C + +     IT +M+CAG  E
Sbjct: 507 RNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLVTNEECQK-RYRGHKITHKMICAGYRE 565

Query: 364 GKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTRVTALRDWITSKT 421
           G  DAC+GDSGGPL S    ++W+L GI SWG+ CA+  +PGVYT V    DWI  KT
Sbjct: 566 GGKDACKGDSGGPL-SCKHNEVWHLVGITSWGEGCAQRERPGVYTNVVEYVDWILEKT 622


>gi|148613878 acrosin precursor [Homo sapiens]
          Length = 421

 Score =  171 bits (433), Expect = 1e-42
 Identities = 97/262 (37%), Positives = 135/262 (51%), Gaps = 17/262 (6%)

Query: 178 CGTRRSKTLGQSLRIVGGTEVEEGEWPWQASLQ--WDGSHR---CGATLINATWLVSAAH 232
           CG R  +     +RIVGG   + G WPW  SLQ     SHR   CG +L+N+ W+++AAH
Sbjct: 29  CGLRFRQNPQGGVRIVGGKAAQHGAWPWMVSLQIFTYNSHRYHTCGGSLLNSRWVLTAAH 88

Query: 233 CFTTYKNPARWTASFGVT---------IKPSKMKRGLRRIIVHEKYKHPSHDYDISLAEL 283
           CF    N   W   FG           +K    +R + +II+HEKY   +   DI+L E+
Sbjct: 89  CFVGKNNVHDWRLVFGAKEITYGNNKPVKAPLQERYVEKIIIHEKYNSATEGNDIALVEI 148

Query: 284 SSPVPYTNAVHRVCLPDASYEFQPGDVM-FVTGFGALKNDGYSQNH-LRQAQVTLIDATT 341
           + P+     +   CLP        G    +V G+G ++      +  L +A+V LID   
Sbjct: 149 TPPISCGRFIGPGCLPHFKAGLPRGSQSCWVAGWGYIEEKAPRPSSILMEARVDLIDLDL 208

Query: 342 CNEPQAYNDAITPRMLCAGSLEGKTDACQGDSGGPLVSSDARDIWY-LAGIVSWGDECAK 400
           CN  Q YN  + P  +CAG   GK D CQGDSGGPL+  D+++  Y + GI SWG  CA+
Sbjct: 209 CNSTQWYNGRVQPTNVCAGYPVGKIDTCQGDSGGPLMCKDSKESAYVVVGITSWGVGCAR 268

Query: 401 PNKPGVYTRVTALRDWITSKTG 422
             +PG+YT      +WI SK G
Sbjct: 269 AKRPGIYTATWPYLNWIASKIG 290


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.134    0.421 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,479,521
Number of Sequences: 37866
Number of extensions: 712284
Number of successful extensions: 2169
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 159
Number of HSP's successfully gapped in prelim test: 25
Number of HSP's that attempted gapping in prelim test: 1536
Number of HSP's gapped (non-prelim): 205
length of query: 423
length of database: 18,247,518
effective HSP length: 105
effective length of query: 318
effective length of database: 14,271,588
effective search space: 4538364984
effective search space used: 4538364984
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.