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Search of human proteins with 40068063
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|40068063 TBC1 domain family, member 22B [Homo sapiens]
(505 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|40068063 TBC1 domain family, member 22B [Homo sapiens] 1029 0.0
gi|22507409 TBC1 domain family, member 22A [Homo sapiens] 638 0.0
gi|190014603 TBC1 domain family, member 13 [Homo sapiens] 93 6e-19
gi|226342869 TBC1 domain family, member 15 isoform 2 [Homo sapiens] 87 3e-17
gi|226342867 TBC1 domain family, member 15 isoform 3 [Homo sapiens] 87 3e-17
gi|226342865 TBC1 domain family, member 15 isoform 1 [Homo sapiens] 87 3e-17
gi|33563376 TBC1 domain family, member 16 [Homo sapiens] 81 3e-15
gi|13375952 TBC1 domain family, member 17 [Homo sapiens] 77 5e-14
gi|34147456 TBC domain-containing protein kinase-like [Homo sapi... 75 1e-13
gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens] 66 6e-11
gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens] 66 6e-11
gi|29648315 small G protein signaling modulator 3 [Homo sapiens] 61 3e-09
gi|148806902 TBC1 domain family, member 12 [Homo sapiens] 59 8e-09
gi|222352143 TBC1 domain family, member 2 [Homo sapiens] 58 2e-08
gi|197304777 TBC1 domain family, member 5 isoform a [Homo sapiens] 57 5e-08
gi|197304775 TBC1 domain family, member 5 isoform b [Homo sapiens] 57 5e-08
gi|7661998 TBC1 domain family, member 5 isoform b [Homo sapiens] 57 5e-08
gi|164565381 TBC1 domain family, member 14 isoform b [Homo sapiens] 57 5e-08
gi|164565368 TBC1 domain family, member 14 isoform a [Homo sapiens] 57 5e-08
gi|164565366 TBC1 domain family, member 14 isoform a [Homo sapiens] 57 5e-08
gi|118722351 growth hormone regulated TBC protein 1 [Homo sapiens] 54 4e-07
gi|54607014 TBC1 domain family, member 25 [Homo sapiens] 51 2e-06
gi|164519084 RAB GTPase activating protein 1 [Homo sapiens] 45 1e-04
gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo... 43 6e-04
gi|13994322 TBC1 domain family, member 10A [Homo sapiens] 43 8e-04
gi|139394668 TBC1 domain family, member 9 (with GRAM domain) [Ho... 43 8e-04
gi|167614488 TBC1 domain family, member 10B [Homo sapiens] 43 8e-04
gi|7661864 USP6 N-terminal like isoform 1 [Homo sapiens] 42 0.001
gi|122937432 USP6 N-terminal like isoform 2 [Homo sapiens] 42 0.001
gi|148612875 RUN and TBC1 domain containing 2 isoform 4 [Homo sa... 41 0.002
>gi|40068063 TBC1 domain family, member 22B [Homo sapiens]
Length = 505
Score = 1029 bits (2661), Expect = 0.0
Identities = 505/505 (100%), Positives = 505/505 (100%)
Query: 1 MAAENSKQFWKRSAKLPGSIQPVYGAQHPPLDPRLTKNFIKERSKVNTVPLKNKKASSFH 60
MAAENSKQFWKRSAKLPGSIQPVYGAQHPPLDPRLTKNFIKERSKVNTVPLKNKKASSFH
Sbjct: 1 MAAENSKQFWKRSAKLPGSIQPVYGAQHPPLDPRLTKNFIKERSKVNTVPLKNKKASSFH 60
Query: 61 EFARNTSDAWDIGDDEEEDFSSPSFQTLNSKVALATAAQVLENHSKLRVKPERSQSTTSD 120
EFARNTSDAWDIGDDEEEDFSSPSFQTLNSKVALATAAQVLENHSKLRVKPERSQSTTSD
Sbjct: 61 EFARNTSDAWDIGDDEEEDFSSPSFQTLNSKVALATAAQVLENHSKLRVKPERSQSTTSD 120
Query: 121 VPANYKVIKSSSDAQLSRNSSDTCLRNPLHKQQSLPLRPIIPLVARISDQNASGAPPMTV 180
VPANYKVIKSSSDAQLSRNSSDTCLRNPLHKQQSLPLRPIIPLVARISDQNASGAPPMTV
Sbjct: 121 VPANYKVIKSSSDAQLSRNSSDTCLRNPLHKQQSLPLRPIIPLVARISDQNASGAPPMTV 180
Query: 181 REKTRLEKFRQLLSSQNTDLDELRKCSWPGVPREVRPITWRLLSGYLPANTERRKLTLQR 240
REKTRLEKFRQLLSSQNTDLDELRKCSWPGVPREVRPITWRLLSGYLPANTERRKLTLQR
Sbjct: 181 REKTRLEKFRQLLSSQNTDLDELRKCSWPGVPREVRPITWRLLSGYLPANTERRKLTLQR 240
Query: 241 KREEYFGFIEQYYDSRNEEHHQDTYRQIHIDIPRTNPLIPLFQQPLVQEIFERILFIWAI 300
KREEYFGFIEQYYDSRNEEHHQDTYRQIHIDIPRTNPLIPLFQQPLVQEIFERILFIWAI
Sbjct: 241 KREEYFGFIEQYYDSRNEEHHQDTYRQIHIDIPRTNPLIPLFQQPLVQEIFERILFIWAI 300
Query: 301 RHPASGYVQGINDLVTPFFVVFLSEYVEEDVENFDVTNLSQDMLRSIEADSFWCMSKLLD 360
RHPASGYVQGINDLVTPFFVVFLSEYVEEDVENFDVTNLSQDMLRSIEADSFWCMSKLLD
Sbjct: 301 RHPASGYVQGINDLVTPFFVVFLSEYVEEDVENFDVTNLSQDMLRSIEADSFWCMSKLLD 360
Query: 361 GIQDNYTFAQPGIQKKVKALEELVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMRELPL 420
GIQDNYTFAQPGIQKKVKALEELVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMRELPL
Sbjct: 361 GIQDNYTFAQPGIQKKVKALEELVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMRELPL 420
Query: 421 RCTIRLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDEEDFQGLLMLLQNLPTIHWGNE 480
RCTIRLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDEEDFQGLLMLLQNLPTIHWGNE
Sbjct: 421 RCTIRLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDEEDFQGLLMLLQNLPTIHWGNE 480
Query: 481 EIGLLLAEAYRLKYMFADAPNHYRR 505
EIGLLLAEAYRLKYMFADAPNHYRR
Sbjct: 481 EIGLLLAEAYRLKYMFADAPNHYRR 505
>gi|22507409 TBC1 domain family, member 22A [Homo sapiens]
Length = 517
Score = 638 bits (1646), Expect = 0.0
Identities = 320/520 (61%), Positives = 396/520 (76%), Gaps = 18/520 (3%)
Query: 1 MAAENS-KQFWKRS-AKLPGSIQPVYGAQHPPLDPRLTKNFIKERSKVNTVPLKNKKASS 58
MA++ + KQFWKRS +KLPGSIQ VYGAQHPP DP L ++ +K+ T P+K K+ S+
Sbjct: 1 MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVST 60
Query: 59 FHEFARNTSDAWDIGDDEEEDFSSPSFQTLNSKVALATAAQVLENHSK------------ 106
F EF NTSDAWD G+D++E + + ++LNS+V + TA +VL NHS+
Sbjct: 61 FQEFESNTSDAWDAGEDDDELLAMAA-ESLNSEVVMETANRVLRNHSQRQGRPTLQEGPG 119
Query: 107 LRVKPERSQSTTSDVPANYKVIKSSSDAQLSRNSSDTCLRNPLHKQQSLPLRPIIPLVAR 166
L+ KP S + +++KS S++ S + PL + QSLP + L
Sbjct: 120 LQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTL-GG 178
Query: 167 ISDQNASGAPPMTVREKTRLEKFRQLLSSQNTDLDELRKCSWPGVPREVRPITWRLLSGY 226
SD + + ++ RE +RL+KF+QLL+ NTDL+ELR+ SW G+P+ VRP+TW+LLSGY
Sbjct: 179 TSDPSTLSSSALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGY 238
Query: 227 LPANTERRKLTLQRKREEYFGFIEQYYDSRNEEHHQDTYRQIHIDIPRTNPLIPLFQQPL 286
LPAN +RR TLQRK++EYF FIE YYDSRN+E HQDTYRQIHIDIPR +P L QP
Sbjct: 239 LPANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEA-LILQPK 297
Query: 287 VQEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFLSEYVE-EDVENFDVTNLSQDMLR 345
V EIFERILFIWAIRHPASGYVQGINDLVTPFFVVF+ EY+E E+V+ DV+ + ++L
Sbjct: 298 VTEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLC 357
Query: 346 SIEADSFWCMSKLLDGIQDNYTFAQPGIQKKVKALEELVSRIDEQVHNHFRRYEVEYLQF 405
+IEAD++WCMSKLLDGIQDNYTFAQPGIQ KVK LEELVSRIDEQVH H ++EV YLQF
Sbjct: 358 NIEADTYWCMSKLLDGIQDNYTFAQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQF 417
Query: 406 AFRWMNNLLMRELPLRCTIRLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDEEDFQGL 465
AFRWMNNLLMRE+PLRCTIRLWDTYQSEP+GFSHFHLYVCAAFL++WRKEIL+E+DFQ L
Sbjct: 418 AFRWMNNLLMREVPLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQEL 477
Query: 466 LMLLQNLPTIHWGNEEIGLLLAEAYRLKYMFADAPNHYRR 505
L+ LQNLPT HW +E+I LLLAEAYRLK+ FADAPNHY++
Sbjct: 478 LLFLQNLPTAHWDDEDISLLLAEAYRLKFAFADAPNHYKK 517
>gi|190014603 TBC1 domain family, member 13 [Homo sapiens]
Length = 400
Score = 92.8 bits (229), Expect = 6e-19
Identities = 61/189 (32%), Positives = 100/189 (52%), Gaps = 19/189 (10%)
Query: 289 EIFERILFIWAIRHPASGYVQGINDLVTPFFVVFLSEYVEEDVENFDVTNLSQDMLRSIE 348
E+ ERILFI+A +P YVQG+N++V P + F T+ + + E
Sbjct: 209 EVVERILFIYAKLNPGIAYVQGMNEIVGPLYYTF-------------ATDPNSEWKEHAE 255
Query: 349 ADSFWCMSKLLDGIQDNYTFA----QPGIQKKVKALEELVSRIDEQVHNHFRRYEVEYLQ 404
AD+F+C + L+ I+DN+ + Q GI K++ + + D +++ + ++
Sbjct: 256 ADTFFCFTNLMAEIRDNFIKSLDDSQCGITYKMEKVYSTLKDKDVELYLKLQEQNIKPQF 315
Query: 405 FAFRWMNNLLMRELPLRCTIRLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDEEDFQG 464
FAFRW+ LL +E L IR+WD+ ++ F F L VC A L+ R+++L E DF
Sbjct: 316 FAFRWLTLLLSQEFLLPDVIRIWDSLFADDNRFD-FLLLVCCAMLMLIREQLL-EGDFTV 373
Query: 465 LLMLLQNLP 473
+ LLQ+ P
Sbjct: 374 NMRLLQDYP 382
Score = 43.5 bits (101), Expect = 4e-04
Identities = 23/76 (30%), Positives = 42/76 (55%), Gaps = 2/76 (2%)
Query: 178 MTVREKTRLEKFRQLLSSQNTDLDELRKCSWPGVPRE--VRPITWRLLSGYLPANTERRK 235
M+ K+R+ F+ +L + L++LR+ S+ G+P E +R + W++L YLP
Sbjct: 1 MSSLHKSRIADFQDVLKEPSIALEKLRELSFSGIPCEGGLRCLCWKILLNYLPLERASWT 60
Query: 236 LTLQRKREEYFGFIEQ 251
L ++RE Y F+ +
Sbjct: 61 SILAKQRELYAQFLRE 76
>gi|226342869 TBC1 domain family, member 15 isoform 2 [Homo sapiens]
Length = 682
Score = 87.4 bits (215), Expect = 3e-17
Identities = 72/296 (24%), Positives = 134/296 (45%), Gaps = 36/296 (12%)
Query: 176 PPMTVREKTRLEKFRQLLSSQNT--DLDELRKCSWPG-VPREVRPITWRLLSGYLP--AN 230
P + RE LE++ + + S+ ++D +++ + G + +R W+ L GY P +
Sbjct: 300 PVVQRREPVSLEEWTKNIDSEGRILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDST 359
Query: 231 TERRKLTLQRKREEYFGFIEQYYDSRNEEHHQDT----YRQ-IHIDIPRTNPLIPLF--Q 283
E R ++K +EYF Q+ E+ +++ YR I D+ RT+ + Q
Sbjct: 360 KEERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEGQ 419
Query: 284 QPLVQEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFLSEYVEEDVENFDVTNLSQDM 343
+ IL + + GYVQG++DL++P V +EN
Sbjct: 420 DNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYV---------MEN---------- 460
Query: 344 LRSIEADSFWCMSKLLDGIQDNYTFAQPGIQKKVKALEELVSRIDEQVHNHFRRYEVEYL 403
E D+FWC + +D + N+ G++ ++ L L+ +D ++ + YL
Sbjct: 461 ----EVDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDSGYL 516
Query: 404 QFAFRWMNNLLMRELPLRCTIRLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDE 459
F FRW+ RE +RLW+ +E ++FHL +C A L +++I+++
Sbjct: 517 YFCFRWLLIRFKREFSFLDILRLWEVMWTELP-CTNFHLLLCCAILESEKQQIMEK 571
>gi|226342867 TBC1 domain family, member 15 isoform 3 [Homo sapiens]
Length = 696
Score = 87.4 bits (215), Expect = 3e-17
Identities = 72/296 (24%), Positives = 134/296 (45%), Gaps = 36/296 (12%)
Query: 176 PPMTVREKTRLEKFRQLLSSQNT--DLDELRKCSWPG-VPREVRPITWRLLSGYLP--AN 230
P + RE LE++ + + S+ ++D +++ + G + +R W+ L GY P +
Sbjct: 314 PVVQRREPVSLEEWTKNIDSEGRILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDST 373
Query: 231 TERRKLTLQRKREEYFGFIEQYYDSRNEEHHQDT----YRQ-IHIDIPRTNPLIPLF--Q 283
E R ++K +EYF Q+ E+ +++ YR I D+ RT+ + Q
Sbjct: 374 KEERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEGQ 433
Query: 284 QPLVQEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFLSEYVEEDVENFDVTNLSQDM 343
+ IL + + GYVQG++DL++P V +EN
Sbjct: 434 DNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYV---------MEN---------- 474
Query: 344 LRSIEADSFWCMSKLLDGIQDNYTFAQPGIQKKVKALEELVSRIDEQVHNHFRRYEVEYL 403
E D+FWC + +D + N+ G++ ++ L L+ +D ++ + YL
Sbjct: 475 ----EVDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDSGYL 530
Query: 404 QFAFRWMNNLLMRELPLRCTIRLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDE 459
F FRW+ RE +RLW+ +E ++FHL +C A L +++I+++
Sbjct: 531 YFCFRWLLIRFKREFSFLDILRLWEVMWTELP-CTNFHLLLCCAILESEKQQIMEK 585
>gi|226342865 TBC1 domain family, member 15 isoform 1 [Homo sapiens]
Length = 713
Score = 87.4 bits (215), Expect = 3e-17
Identities = 72/296 (24%), Positives = 134/296 (45%), Gaps = 36/296 (12%)
Query: 176 PPMTVREKTRLEKFRQLLSSQNT--DLDELRKCSWPG-VPREVRPITWRLLSGYLP--AN 230
P + RE LE++ + + S+ ++D +++ + G + +R W+ L GY P +
Sbjct: 331 PVVQRREPVSLEEWTKNIDSEGRILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDST 390
Query: 231 TERRKLTLQRKREEYFGFIEQYYDSRNEEHHQDT----YRQ-IHIDIPRTNPLIPLF--Q 283
E R ++K +EYF Q+ E+ +++ YR I D+ RT+ + Q
Sbjct: 391 KEERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEGQ 450
Query: 284 QPLVQEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFLSEYVEEDVENFDVTNLSQDM 343
+ IL + + GYVQG++DL++P V +EN
Sbjct: 451 DNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYV---------MEN---------- 491
Query: 344 LRSIEADSFWCMSKLLDGIQDNYTFAQPGIQKKVKALEELVSRIDEQVHNHFRRYEVEYL 403
E D+FWC + +D + N+ G++ ++ L L+ +D ++ + YL
Sbjct: 492 ----EVDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDSGYL 547
Query: 404 QFAFRWMNNLLMRELPLRCTIRLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDE 459
F FRW+ RE +RLW+ +E ++FHL +C A L +++I+++
Sbjct: 548 YFCFRWLLIRFKREFSFLDILRLWEVMWTELP-CTNFHLLLCCAILESEKQQIMEK 602
>gi|33563376 TBC1 domain family, member 16 [Homo sapiens]
Length = 767
Score = 80.9 bits (198), Expect = 3e-15
Identities = 76/307 (24%), Positives = 131/307 (42%), Gaps = 50/307 (16%)
Query: 210 GVPREVRPITWRLLSGYLP---ANTERRKLTLQRKREEYFGFIEQYYDSRNEEHHQDTYR 266
G+ +R W L Y + ER L LQ+++E + I+Q S E H+ +R
Sbjct: 425 GIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRKE--YSEIQQKRLSMTPEEHRAFWR 482
Query: 267 QIHI----DIPRTNPLIPLFQ---QPLVQEIFERILFIWAIRHPASGYVQGINDLVTPFF 319
+ D+ RT+ F+ P V+ + RIL +A+ +PA GY QG++DLV P
Sbjct: 483 NVQFTVDKDVVRTDRNNQFFRGEDNPNVESM-RRILLNYAVYNPAVGYSQGMSDLVAPIL 541
Query: 320 VVFLSEYVEEDVENFDVTNLSQDMLRSIEADSFWCMSKLLDGIQDNYTFAQPGIQKKVKA 379
L E+D+FWC L+ + ++K++
Sbjct: 542 AEVLD-----------------------ESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLY 578
Query: 380 LEELVSRIDEQVHNHFRRYEVEYLQ--FAFRWMNNLLMRELPLRCTIRLWDT----YQSE 433
L EL+ + + H + LQ F RW+ RE P +R+W+ YQ++
Sbjct: 579 LRELLRLTHVRFYQHLVSLGEDGLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHYQTD 638
Query: 434 PEGFSHFHLYVCAAFLIKWRKEILDEEDFQGLLMLLQNLPTIHWGNEEIGLLLAEAYRLK 493
+FHL++C A + + ++++++ ++L +H E L+L +A L
Sbjct: 639 -----YFHLFICVAIVAIYGDDVIEQQLATDQMLLHFGNLAMHMNGE---LVLRKARSLL 690
Query: 494 YMFADAP 500
Y F P
Sbjct: 691 YQFRLLP 697
>gi|13375952 TBC1 domain family, member 17 [Homo sapiens]
Length = 648
Score = 76.6 bits (187), Expect = 5e-14
Identities = 63/249 (25%), Positives = 109/249 (43%), Gaps = 33/249 (13%)
Query: 210 GVPREVRPITWRLLSGYLP--ANTERRKLTLQRKREEYFGFIEQYYDSRNEEHHQDT--- 264
G+ +R W+ L GYL E K +++K +EYF Q+ E+ +++
Sbjct: 310 GLSPSLRREAWKFLLGYLSWEGTAEEHKAHIRKKTDEYFRMKLQWKSVSPEQERRNSLLH 369
Query: 265 -YRQ-IHIDIPRTNPLIPLFQQPLVQEI--FERILFIWAIRHPASGYVQGINDLVTPFFV 320
YR I D+ RT+ ++ P + IL + + H GYVQG++DL++P
Sbjct: 370 GYRSLIERDVSRTDRTNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSPILY 429
Query: 321 VFLSEYVEEDVENFDVTNLSQDMLRSIEADSFWCMSKLLDGIQDNYTFAQPGIQKKVKAL 380
V ++N E D+FWC ++ +Q N+ +Q +++++ L
Sbjct: 430 V---------IQN--------------EVDAFWCFCGFMELVQGNFEESQETMKRQLGRL 466
Query: 381 EELVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMRELPLRCTIRLWDTYQSEPEGFSHF 440
L+ +D + + + L F FRW+ RE P +RLW+ + G +
Sbjct: 467 LLLLRVLDPLLCDFLDSQDSGSLCFCFRWLLIWFKREFPFPDVLRLWEVLWTGLPG-PNL 525
Query: 441 HLYVCAAFL 449
HL V A L
Sbjct: 526 HLLVACAIL 534
>gi|34147456 TBC domain-containing protein kinase-like [Homo
sapiens]
Length = 830
Score = 75.1 bits (183), Expect = 1e-13
Identities = 75/316 (23%), Positives = 123/316 (38%), Gaps = 53/316 (16%)
Query: 168 SDQNASGAPPMTVREK------TRLEKFRQLLSSQNTDLDELRKCSWPGVPREVRPITWR 221
++ +A+ P+ +REK R+ F +LL + +++ K + +P +R +TW
Sbjct: 355 NELSAAATLPLIIREKDTEYQLNRIILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWA 414
Query: 222 LLSGYLPANTERRKLTLQRKREEYFGFIEQYYDSRNEEHHQDTYRQIHIDIPRTNPLIPL 281
L G G I YD+ +++ T RQI +DIPR + L
Sbjct: 415 ALLGVE-------------------GAIHAKYDAIDKDTPIPTDRQIEVDIPRCHQYDEL 455
Query: 282 FQQPLVQEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFLSEYVEEDVENFDVTNLSQ 341
P F R+L W + HP Y QG++ L PF + NF
Sbjct: 456 LSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYL-----------NF------- 497
Query: 342 DMLRSIEADSFWCMSKLLDGIQDNYTFAQPG--IQKKVKALEELVSRIDEQVHNHFRRYE 399
+ EA ++ CMS + N+ IQ+ + ++++ D ++ NH
Sbjct: 498 ----NNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELSNHLNEIG 553
Query: 400 VEYLQFAFRWMNNLLMRELPLRCTIRLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDE 459
+A W + PL LWDT G S F + A L + R +L
Sbjct: 554 FIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLL---GNSSFPFCIGVAILQQLRDRLL-A 609
Query: 460 EDFQGLLMLLQNLPTI 475
F ++L +LP I
Sbjct: 610 NGFNECILLFSDLPEI 625
>gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens]
Length = 963
Score = 66.2 bits (160), Expect = 6e-11
Identities = 61/273 (22%), Positives = 112/273 (41%), Gaps = 41/273 (15%)
Query: 202 ELRKCSWPGVPREVRPITWRLLSGYLPANTERRKLTLQRKREEYFGFIEQYYDSRNEEHH 261
EL+ G+P E R W+ + RK + + +++ + +N
Sbjct: 654 ELKNLIRAGIPHEHRSKVWKWC-----VDRHTRKFKDNTEPGHFQTLLQKALEKQNPAS- 707
Query: 262 QDTYRQIHIDIPRTNPLIPLFQQPLVQEI--FERILFIWAIRHPASGYVQGINDLVTPFF 319
+QI +D+ RT P + P + I +L ++ R+P GY QG+N LV
Sbjct: 708 ----KQIELDLLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVAL 763
Query: 320 VVFLSEYVEEDVENFDVTNLSQDMLRSIEADSFWCMSKLLDGI--QDNYTFAQPGIQKKV 377
+ Y+E++ D+FWC+ +++ +D YT G Q
Sbjct: 764 L-----YLEQE-------------------DAFWCLVTIVEVFMPRDYYTKTLLGSQVDQ 799
Query: 378 KALEELVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMRELPLRCTIRLWDTYQSEPEGF 437
+ +L+S ++H HF +Y+V+Y F W + + + ++WD++ EG
Sbjct: 800 RVFRDLMSEKLPRLHGHFEQYKVDYTLITFNWFLVVFVDSVVSDILFKIWDSFLY--EGP 857
Query: 438 SHFHLYVCAAFLIKWRKEILDEEDFQGLLMLLQ 470
+ A F K +EIL +D + L+
Sbjct: 858 KVIFRFALALFKYK-EEEILKLQDSMSIFKYLR 889
>gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens]
Length = 914
Score = 66.2 bits (160), Expect = 6e-11
Identities = 61/273 (22%), Positives = 112/273 (41%), Gaps = 41/273 (15%)
Query: 202 ELRKCSWPGVPREVRPITWRLLSGYLPANTERRKLTLQRKREEYFGFIEQYYDSRNEEHH 261
EL+ G+P E R W+ + RK + + +++ + +N
Sbjct: 654 ELKNLIRAGIPHEHRSKVWKWC-----VDRHTRKFKDNTEPGHFQTLLQKALEKQNPAS- 707
Query: 262 QDTYRQIHIDIPRTNPLIPLFQQPLVQEI--FERILFIWAIRHPASGYVQGINDLVTPFF 319
+QI +D+ RT P + P + I +L ++ R+P GY QG+N LV
Sbjct: 708 ----KQIELDLLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVAL 763
Query: 320 VVFLSEYVEEDVENFDVTNLSQDMLRSIEADSFWCMSKLLDGI--QDNYTFAQPGIQKKV 377
+ Y+E++ D+FWC+ +++ +D YT G Q
Sbjct: 764 L-----YLEQE-------------------DAFWCLVTIVEVFMPRDYYTKTLLGSQVDQ 799
Query: 378 KALEELVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMRELPLRCTIRLWDTYQSEPEGF 437
+ +L+S ++H HF +Y+V+Y F W + + + ++WD++ EG
Sbjct: 800 RVFRDLMSEKLPRLHGHFEQYKVDYTLITFNWFLVVFVDSVVSDILFKIWDSFLY--EGP 857
Query: 438 SHFHLYVCAAFLIKWRKEILDEEDFQGLLMLLQ 470
+ A F K +EIL +D + L+
Sbjct: 858 KVIFRFALALFKYK-EEEILKLQDSMSIFKYLR 889
>gi|29648315 small G protein signaling modulator 3 [Homo sapiens]
Length = 749
Score = 60.8 bits (146), Expect = 3e-09
Identities = 67/302 (22%), Positives = 115/302 (38%), Gaps = 47/302 (15%)
Query: 201 DELRKCSWPGVPREVRPITWRLLSGYLPANTERRKLTLQRKREEYFGFIEQYYDSRNEEH 260
++LR G+P +RP W LSG LQ+KR + E +S N+E
Sbjct: 105 EKLRSLVLAGIPHGMRPQLWMRLSG-----------ALQKKRNSELSYREIVKNSSNDE- 152
Query: 261 HQDTYRQIHIDIPRTNPLIPLFQQ--PLVQEIFERILFIWAIRHPASGYVQGINDLVTPF 318
+QI D+ RT P F + R+L A +P GY QG +V
Sbjct: 153 -TIAAKQIEKDLLRTMPSNACFASMGSIGVPRLRRVLRALAWLYPEIGYCQGTG-MVAAC 210
Query: 319 FVVFLSEYVEEDVENFDVTNLSQDMLRSIEADSFWCMSKLLDGIQDNYTFAQP--GIQKK 376
++FL E D+FW MS +++ + F+ G+Q
Sbjct: 211 LLLFLEE-----------------------EDAFWMMSAIIEDLLPASYFSTTLLGVQTD 247
Query: 377 VKALEELVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMRELPLRCTIRLWDTYQSEPEG 436
+ L L+ + ++ + +++E W + ++ +R+WD + E
Sbjct: 248 QRVLRHLIVQYLPRLDKLLQEHDIELSLITLHWFLTAFASVVDIKLLLRIWDLFFYEG-- 305
Query: 437 FSHFHLYVCAAFLIKWRKEILDEEDFQGLLMLLQNLPTIHWGNEEIGLLLAEAYRLKYMF 496
S + L +E++ E+ + L ++P+ E+ LLL A RL
Sbjct: 306 -SRVLFQLTLGMLHLKEEELIQSENSASIFNTLSDIPS---QMEDAELLLGVAMRLAGSL 361
Query: 497 AD 498
D
Sbjct: 362 TD 363
>gi|148806902 TBC1 domain family, member 12 [Homo sapiens]
Length = 775
Score = 59.3 bits (142), Expect = 8e-09
Identities = 68/279 (24%), Positives = 114/279 (40%), Gaps = 36/279 (12%)
Query: 203 LRKCSWPGVPREVRPITWRLLSG-YLPANTERRKLTLQRKREEYFGFIEQYYDSRNE--- 258
+R+ W G+P VR W L G L E ++ L R +E + F E ++ E
Sbjct: 477 VRELWWQGLPPSVRGKVWSLAVGNELNITPELYEIFLSRAKERWKSFSETSSENDTEGVS 536
Query: 259 -EHHQDTYRQIHIDIPRTNPLIPLFQQ-PLVQEIFERILFIWAIRHPASGYVQGINDLVT 316
+ + I +DI RT P + +FQ+ ++ IL + P GYVQG++
Sbjct: 537 VADREASLELIKLDISRTFPSLYIFQKGGPYHDVLHSILGAYTCYRPDVGYVQGMS---- 592
Query: 317 PFFVVFLSEYVEEDVENFDVTNLSQDMLRSIEADSFWCMSKLLD-GIQDNYTFAQPGIQK 375
F L + NL EAD+F + LL+ Q + +
Sbjct: 593 -FIAAVL------------ILNLE-------EADAFIAFANLLNKPCQLAFFRVDHSMML 632
Query: 376 KVKALEELVSRID-EQVHNHFRRYEVEYLQFAFRWMNNLLMRELPLRCTIRLWDTYQSEP 434
K A E+ + ++ HF+ Y + + W+ L + LPL R+WD + +
Sbjct: 633 KYFATFEVFFEENLSKLFLHFKSYSLTPDIYLIDWIFTLYSKSLPLDLACRVWDVFCRDG 692
Query: 435 EGFSHFHLYVCAAFLIKWRKEILDEEDFQGLLMLLQNLP 473
E F L+ +++ ++IL + DF + L LP
Sbjct: 693 EEF----LFRTGLGILRLYEDILLQMDFIHIAQFLTKLP 727
>gi|222352143 TBC1 domain family, member 2 [Homo sapiens]
Length = 917
Score = 58.2 bits (139), Expect = 2e-08
Identities = 57/236 (24%), Positives = 94/236 (39%), Gaps = 40/236 (16%)
Query: 202 ELRKCSWPGVPREVRPITWRLLSGYLPANTERRKLTLQRKREEYFGFIEQYYDSRNEEHH 261
EL++ GVPRE RP WR L + L+ + G ++ SR +
Sbjct: 617 ELKQLLRAGVPREHRPRVWRWL------------VHLRVQHLHTPGCYQELL-SRGQARE 663
Query: 262 QDTYRQIHIDIPRTNPLIPLFQQPL--VQEIFERILFIWAIRHPASGYVQGINDLVTPFF 319
RQI +D+ RT P F P + R+L ++ ++P GY QG+N L
Sbjct: 664 HPAARQIELDLNRTFPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIAL 723
Query: 320 VVFLSEYVEEDVENFDVTNLSQDMLRSIEADSFWCMSKLLDGIQ--DNYTFAQPGIQKKV 377
+V +EE E +FWC+ +++ I D Y Q
Sbjct: 724 LV-----LEE------------------EESAFWCLVAIVETIMPADYYCNTLTASQVDQ 760
Query: 378 KALEELVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMRELPLRCTIRLWDTYQSE 433
+ L++L+S ++ H ++ V+ F W + L +R+WD + E
Sbjct: 761 RVLQDLLSEKLPRLMAHLGQHHVDLSLVTFNWFLVVFADSLISNILLRVWDAFLYE 816
>gi|197304777 TBC1 domain family, member 5 isoform a [Homo sapiens]
Length = 817
Score = 56.6 bits (135), Expect = 5e-08
Identities = 58/239 (24%), Positives = 107/239 (44%), Gaps = 34/239 (14%)
Query: 268 IHIDIPRTNPLIPLFQQPLVQEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFLSEYV 327
I D+ RT P + FQQ V++I +LF +A + Y QG+++L+ P V ++
Sbjct: 163 IEQDVKRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDH- 221
Query: 328 EEDVENFDVTNLSQDML-----RSIEADSFWCMSKLL------------DGIQDNYT--- 367
+ + + S++M +E D++ S+L+ DG + T
Sbjct: 222 QAFLHASESAQPSEEMKTVLNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMT 281
Query: 368 ---FAQP-------GIQKKVKALEE-LVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMR 416
FA+P I KV +++ L+ + D +++ H R E+ + RW+ L R
Sbjct: 282 PIPFARPQDLGPTIAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGR 341
Query: 417 ELPLRCTIRLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDEEDFQGLLMLLQNLPTI 475
E PL+ + +WD ++ Y+ A L+ + ++ L ++Q L LL + P I
Sbjct: 342 EFPLQDLLVVWDALFADGLSLGLVD-YIFVAMLL-YIRDALISSNYQTCLGLLMHYPFI 398
>gi|197304775 TBC1 domain family, member 5 isoform b [Homo sapiens]
Length = 795
Score = 56.6 bits (135), Expect = 5e-08
Identities = 58/239 (24%), Positives = 107/239 (44%), Gaps = 34/239 (14%)
Query: 268 IHIDIPRTNPLIPLFQQPLVQEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFLSEYV 327
I D+ RT P + FQQ V++I +LF +A + Y QG+++L+ P V ++
Sbjct: 163 IEQDVKRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDH- 221
Query: 328 EEDVENFDVTNLSQDML-----RSIEADSFWCMSKLL------------DGIQDNYT--- 367
+ + + S++M +E D++ S+L+ DG + T
Sbjct: 222 QAFLHASESAQPSEEMKTVLNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMT 281
Query: 368 ---FAQP-------GIQKKVKALEE-LVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMR 416
FA+P I KV +++ L+ + D +++ H R E+ + RW+ L R
Sbjct: 282 PIPFARPQDLGPTIAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGR 341
Query: 417 ELPLRCTIRLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDEEDFQGLLMLLQNLPTI 475
E PL+ + +WD ++ Y+ A L+ + ++ L ++Q L LL + P I
Sbjct: 342 EFPLQDLLVVWDALFADGLSLGLVD-YIFVAMLL-YIRDALISSNYQTCLGLLMHYPFI 398
>gi|7661998 TBC1 domain family, member 5 isoform b [Homo sapiens]
Length = 795
Score = 56.6 bits (135), Expect = 5e-08
Identities = 58/239 (24%), Positives = 107/239 (44%), Gaps = 34/239 (14%)
Query: 268 IHIDIPRTNPLIPLFQQPLVQEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFLSEYV 327
I D+ RT P + FQQ V++I +LF +A + Y QG+++L+ P V ++
Sbjct: 163 IEQDVKRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDH- 221
Query: 328 EEDVENFDVTNLSQDML-----RSIEADSFWCMSKLL------------DGIQDNYT--- 367
+ + + S++M +E D++ S+L+ DG + T
Sbjct: 222 QAFLHASESAQPSEEMKTVLNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMT 281
Query: 368 ---FAQP-------GIQKKVKALEE-LVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMR 416
FA+P I KV +++ L+ + D +++ H R E+ + RW+ L R
Sbjct: 282 PIPFARPQDLGPTIAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGR 341
Query: 417 ELPLRCTIRLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDEEDFQGLLMLLQNLPTI 475
E PL+ + +WD ++ Y+ A L+ + ++ L ++Q L LL + P I
Sbjct: 342 EFPLQDLLVVWDALFADGLSLGLVD-YIFVAMLL-YIRDALISSNYQTCLGLLMHYPFI 398
>gi|164565381 TBC1 domain family, member 14 isoform b [Homo sapiens]
Length = 413
Score = 56.6 bits (135), Expect = 5e-08
Identities = 69/282 (24%), Positives = 110/282 (39%), Gaps = 38/282 (13%)
Query: 202 ELRKCSWPGVPREVRPITWRLLSG-YLPANTERRKLTLQRKREEYFGFIEQYYDSRNEE- 259
++R W G+P VR W L G L E + L R +E + + NE+
Sbjct: 113 KVRDLWWQGIPPSVRGKVWSLAIGNELNITHELFDICLARAKERWRSLSTGGSEVENEDA 172
Query: 260 -----HHQDTYRQIHIDIPRTNPLIPLFQQ-PLVQEIFERILFIWAIRHPASGYVQGIND 313
+ + I +DI RT P + +FQQ ++ IL + P GYVQG++
Sbjct: 173 GFSAADREASLELIKLDISRTFPNLCIFQQGGPYHDMLHSILGAYTCYRPDVGYVQGMS- 231
Query: 314 LVTPFFVVFLSEYVEEDVENFDVTNLSQDMLRSIEADSFWCMSKLLD-GIQDNYTFAQPG 372
F L + N D AD+F S LL+ Q + G
Sbjct: 232 ----FIAAVL-------ILNLDT------------ADAFIAFSNLLNKPCQMAFFRVDHG 268
Query: 373 IQ-KKVKALEELVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMRELPLRCTIRLWDTYQ 431
+ A E ++ HF++ + + W+ L + LPL R+WD +
Sbjct: 269 LMLTYFAAFEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFC 328
Query: 432 SEPEGFSHFHLYVCAAFLIKWRKEILDEEDFQGLLMLLQNLP 473
+ E F L+ A ++K ++IL + DF + L LP
Sbjct: 329 RDGEEF----LFRTALGILKLFEDILTKMDFIHMAQFLTRLP 366
>gi|164565368 TBC1 domain family, member 14 isoform a [Homo sapiens]
Length = 693
Score = 56.6 bits (135), Expect = 5e-08
Identities = 69/282 (24%), Positives = 110/282 (39%), Gaps = 38/282 (13%)
Query: 202 ELRKCSWPGVPREVRPITWRLLSG-YLPANTERRKLTLQRKREEYFGFIEQYYDSRNEE- 259
++R W G+P VR W L G L E + L R +E + + NE+
Sbjct: 393 KVRDLWWQGIPPSVRGKVWSLAIGNELNITHELFDICLARAKERWRSLSTGGSEVENEDA 452
Query: 260 -----HHQDTYRQIHIDIPRTNPLIPLFQQ-PLVQEIFERILFIWAIRHPASGYVQGIND 313
+ + I +DI RT P + +FQQ ++ IL + P GYVQG++
Sbjct: 453 GFSAADREASLELIKLDISRTFPNLCIFQQGGPYHDMLHSILGAYTCYRPDVGYVQGMS- 511
Query: 314 LVTPFFVVFLSEYVEEDVENFDVTNLSQDMLRSIEADSFWCMSKLLD-GIQDNYTFAQPG 372
F L + N D AD+F S LL+ Q + G
Sbjct: 512 ----FIAAVL-------ILNLDT------------ADAFIAFSNLLNKPCQMAFFRVDHG 548
Query: 373 IQ-KKVKALEELVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMRELPLRCTIRLWDTYQ 431
+ A E ++ HF++ + + W+ L + LPL R+WD +
Sbjct: 549 LMLTYFAAFEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFC 608
Query: 432 SEPEGFSHFHLYVCAAFLIKWRKEILDEEDFQGLLMLLQNLP 473
+ E F L+ A ++K ++IL + DF + L LP
Sbjct: 609 RDGEEF----LFRTALGILKLFEDILTKMDFIHMAQFLTRLP 646
>gi|164565366 TBC1 domain family, member 14 isoform a [Homo sapiens]
Length = 693
Score = 56.6 bits (135), Expect = 5e-08
Identities = 69/282 (24%), Positives = 110/282 (39%), Gaps = 38/282 (13%)
Query: 202 ELRKCSWPGVPREVRPITWRLLSG-YLPANTERRKLTLQRKREEYFGFIEQYYDSRNEE- 259
++R W G+P VR W L G L E + L R +E + + NE+
Sbjct: 393 KVRDLWWQGIPPSVRGKVWSLAIGNELNITHELFDICLARAKERWRSLSTGGSEVENEDA 452
Query: 260 -----HHQDTYRQIHIDIPRTNPLIPLFQQ-PLVQEIFERILFIWAIRHPASGYVQGIND 313
+ + I +DI RT P + +FQQ ++ IL + P GYVQG++
Sbjct: 453 GFSAADREASLELIKLDISRTFPNLCIFQQGGPYHDMLHSILGAYTCYRPDVGYVQGMS- 511
Query: 314 LVTPFFVVFLSEYVEEDVENFDVTNLSQDMLRSIEADSFWCMSKLLD-GIQDNYTFAQPG 372
F L + N D AD+F S LL+ Q + G
Sbjct: 512 ----FIAAVL-------ILNLDT------------ADAFIAFSNLLNKPCQMAFFRVDHG 548
Query: 373 IQ-KKVKALEELVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMRELPLRCTIRLWDTYQ 431
+ A E ++ HF++ + + W+ L + LPL R+WD +
Sbjct: 549 LMLTYFAAFEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFC 608
Query: 432 SEPEGFSHFHLYVCAAFLIKWRKEILDEEDFQGLLMLLQNLP 473
+ E F L+ A ++K ++IL + DF + L LP
Sbjct: 609 RDGEEF----LFRTALGILKLFEDILTKMDFIHMAQFLTRLP 646
>gi|118722351 growth hormone regulated TBC protein 1 [Homo sapiens]
Length = 336
Score = 53.5 bits (127), Expect = 4e-07
Identities = 61/254 (24%), Positives = 99/254 (38%), Gaps = 46/254 (18%)
Query: 210 GVPREVRPITWRLLSGYLPANTERRKLTLQRKREEYFGFIEQYYDSRNEEHHQDTYRQIH 269
GVP E R W +LSG Q + ++ G+ Q +D R
Sbjct: 68 GVPLEHRARVWMVLSG------------AQAQMDQNPGYYHQLLQGERNPRLEDAIRT-- 113
Query: 270 IDIPRTNPLIPLFQQ---PLVQEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFLSEY 326
D+ RT P F++ P +Q +L + + GY QG+N F++ Y
Sbjct: 114 -DLNRTFPDNVKFRKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMN---------FIAGY 163
Query: 327 VEEDVENFDVTNLSQDMLRSIEADSFWCMSKLLDGI-QDNYTFAQPGIQKKVKALEELVS 385
+ ++ + E +SFW + L+ I D Y+ A G++ + L ELV
Sbjct: 164 LI--------------LITNNEEESFWLLDALVGRILPDYYSPAMLGLKTDQEVLGELVR 209
Query: 386 RIDEQVHNHFRRYEVEYLQFAFRWMNNLLMRELPLRCTIRLWDTYQSEPEGFSHFHLYVC 445
V R V + RW L + LP+ +R+WD +E ++
Sbjct: 210 AKLPAVGALMERLGVLWTLLVSRWFICLFVDILPVETVLRIWDCLFNEGSKI----IFRV 265
Query: 446 AAFLIKWRKEILDE 459
A LIK +E++ E
Sbjct: 266 ALTLIKQHQELILE 279
>gi|54607014 TBC1 domain family, member 25 [Homo sapiens]
Length = 688
Score = 51.2 bits (121), Expect = 2e-06
Identities = 51/231 (22%), Positives = 89/231 (38%), Gaps = 29/231 (12%)
Query: 210 GVPREVRPITWR-LLSGYLPANTERRKLT-LQRKREEYFGFIEQYYDSRNEEHHQDTYRQ 267
GV +R + WR LL+ Y T R ++ ++RK EY ++ N E +
Sbjct: 228 GVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRANPEDLEFIRST 287
Query: 268 IHIDIPRTNPLIPLFQQPLVQ---EIFERILFIWAIRHPASGYVQGINDLVTPFFVVFLS 324
+ D+ RT+ P + P +L +A+ HP Y QG++DL +P V
Sbjct: 288 VLKDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVM-- 345
Query: 325 EYVEEDVENFDVTNLSQDMLRSIEADSFWCMSKLLDGIQDNYTFAQPGIQKKVKALEELV 384
E +F C ++ + N+ + K L+ L+
Sbjct: 346 ---------------------DHEGHAFVCFCGIMKRLAANFHPDGRAMATKFAHLKLLL 384
Query: 385 SRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMRELPLRCTIRLWD-TYQSEP 434
D + + + + L F +RW+ L RE +R+ + T+ S P
Sbjct: 385 RHADPDFYQYLQEAGADDLFFCYRWLLLELKREFAFDDALRMLEVTWSSLP 435
>gi|164519084 RAB GTPase activating protein 1 [Homo sapiens]
Length = 1069
Score = 45.4 bits (106), Expect = 1e-04
Identities = 90/403 (22%), Positives = 151/403 (37%), Gaps = 64/403 (15%)
Query: 106 KLRVKPERSQSTTSDVPANYKVIKSSSDAQLSRNSSDTCLRNPLHKQQSLPLRPIIPLVA 165
KL+ +R + +D ++S S+ + + ++ +R P QS +IP
Sbjct: 455 KLKQIKQRERKNNTDTLYEVVCLESESERERRKTTASPSVRLPQSGSQS----SVIPSPP 510
Query: 166 RISDQNASGAPPMT--------VREKTRLEKFRQLLSSQNTDLD----ELRKCSWPGVPR 213
++ + P ++ EK LE + +LLS + +L+ +L GVP
Sbjct: 511 EDDEEEDNDEPLLSGSGDVSKECAEKI-LETWGELLSKWHLNLNVRPKQLSSLVRNGVPE 569
Query: 214 EVRPITWRLLSGYLPANTERRKLTLQRKREEYFGFIEQYYDSRNEEHHQDTYRQIHIDIP 273
+R W+LL+G N + +E+Y +E QD+ I DI
Sbjct: 570 ALRGEVWQLLAGC--HNNDH--------------LVEKYRILITKESPQDS--AITRDIN 611
Query: 274 RTNPLIPLFQQPLV--QEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFLSEYVEEDV 331
RT P F+ Q+ +I +++ GY QG + L V L EE
Sbjct: 612 RTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQSFLAA----VLLLHMPEEQA 667
Query: 332 ENFDVTNLSQDMLRSIEADSFWCMSKLLDGIQDNYTFAQPGIQKKVKALEELVSRIDEQV 391
+ V + LR + +F + K LE L+ +
Sbjct: 668 FSVLVKIMFDYGLRELFKQNF------------------EDLHCKFYQLERLMQEYIPDL 709
Query: 392 HNHFRRYEVEYLQFAFRWMNNLLMRELPLRCTIRLWDTYQSEPEGFSHFHLYVCAAFLIK 451
+NHF +E +A +W L + PL + D EG S ++ A L+K
Sbjct: 710 YNHFLDISLEAHMYASQWFLTLFTAKFPLYMVFHIIDLLLC--EGIS--VIFNVALGLLK 765
Query: 452 WRKEILDEEDFQGLLMLLQ-NLPTIHWGNEEIGLLLAEAYRLK 493
K+ L DF+G L + LP + E L+ A +K
Sbjct: 766 TSKDDLLLTDFEGALKFFRVQLPKRYRSEENAKKLMELACNMK 808
>gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo
sapiens]
Length = 815
Score = 43.1 bits (100), Expect = 6e-04
Identities = 71/313 (22%), Positives = 116/313 (37%), Gaps = 54/313 (17%)
Query: 186 LEKFRQLLSSQNTDLDELRKCSWPGVPREVRPITWRLLSGYLPANTERRKLTLQRKREEY 245
L K+ L ++ L L K GVP +R W+LL+G +
Sbjct: 517 LGKWHSNLGARPKGLSTLVKS---GVPEALRAEVWQLLAGC----------------HDN 557
Query: 246 FGFIEQYYDSRNEEHHQDTYRQIHIDIPRTNPLIPLFQQPLV--QEIFERILFIWAIRHP 303
+++Y ++ Q++ I DI RT P F+ QE +I +++
Sbjct: 558 QAMLDRYRILITKDSAQESV--ITRDIHRTFPAHDYFKDTGGDGQESLYKICKAYSVYDE 615
Query: 304 ASGYVQGINDLVTPFFVVFLSEYVEEDVENFDVTNLSQDMLRSIEADSFWCMSKLLD--G 361
GY QG + L +L E +F + K++ G
Sbjct: 616 DIGYCQGQSFLAAVL------------------------LLHMPEEQAFCVLVKIMYDYG 651
Query: 362 IQDNYTFAQPGIQKKVKALEELVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMRELPLR 421
++D Y + K LE L+ +H+HF +E +A +W L + PL
Sbjct: 652 LRDLYRNNFEDLHCKFYQLERLMQEQLPDLHSHFSDLNLEAHMYASQWFLTLFTAKFPLC 711
Query: 422 CTIRLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDEEDFQGLLMLLQ-NLPTIHWGNE 480
+ D E FH+ A L+K KE L + DF+G L + LP + E
Sbjct: 712 MVFHIIDLLLCEGLNII-FHV---ALALLKTSKEDLLQADFEGALKFFRVQLPKRYRAEE 767
Query: 481 EIGLLLAEAYRLK 493
L+ +A +K
Sbjct: 768 NARRLMEQACNIK 780
>gi|13994322 TBC1 domain family, member 10A [Homo sapiens]
Length = 508
Score = 42.7 bits (99), Expect = 8e-04
Identities = 60/277 (21%), Positives = 98/277 (35%), Gaps = 50/277 (18%)
Query: 167 ISDQNASGAPPMTVREKTRLEKFRQLLSSQNTDL------DELRKCSWPGVPREVRPITW 220
+ Q A GA E R + + L N D ++R G+P +R W
Sbjct: 62 VGSQGAEGALEEVPLEVLRQRESKWLDMLNNWDKWMAKKHKKIRLRCQKGIPPSLRGRAW 121
Query: 221 RLLSGYLPANTERRKLTLQRKREEYFGFIEQYYDSRNEEHHQDTYRQIHIDIPRTNPLIP 280
+ LSG K+ LQ+ G ++ S + D I D+ R P
Sbjct: 122 QYLSG--------GKVKLQQNP----GKFDELDMSPGDPKWLDV---IERDLHRQFPFHE 166
Query: 281 LFQQPL---VQEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFLSEYVEEDVENFDVT 337
+F Q++F R+L + + P GY Q P V L E
Sbjct: 167 MFVSRGGHGQQDLF-RVLKAYTLYRPEEGYCQA----QAPIAAVLLMHMPAEQ------- 214
Query: 338 NLSQDMLRSIEADSFWCMSKLLDG-IQDNYTFAQPGIQKKVKALEELVSRIDEQVHNHFR 396
+FWC+ ++ + + Y+ IQ + L L+ ++ H H
Sbjct: 215 -------------AFWCLVQICEKYLPGYYSEKLEAIQLDGEILFSLLQKVSPVAHKHLS 261
Query: 397 RYEVEYLQFAFRWMNNLLMRELPLRCTIRLWDTYQSE 433
R +++ L + W R LP +R+WD + E
Sbjct: 262 RQKIDPLLYMTEWFMCAFSRTLPWSSVLRVWDMFFCE 298
>gi|139394668 TBC1 domain family, member 9 (with GRAM domain) [Homo
sapiens]
Length = 1266
Score = 42.7 bits (99), Expect = 8e-04
Identities = 31/125 (24%), Positives = 57/125 (45%), Gaps = 14/125 (11%)
Query: 201 DELRKCSWPGVPREVRPITWRLLSGYLPANTERRKLTLQRKREEYFGFIEQYYDSRNEEH 260
++ R+ G+P +R W LLSG + ++ + G+ E + ++
Sbjct: 506 EKTRELVLKGIPESMRGELWLLLSGAI------------NEKATHPGYYEDLVEKSMGKY 553
Query: 261 HQDTYRQIHIDIPRTNPLIPLFQQPLVQEIFERILFIWAIRHPASGYVQGINDLVTPFFV 320
+ T +I D+ R+ P P FQ + R+L +A R+P GY Q +N +VT +
Sbjct: 554 NLAT-EEIERDLHRSLPEHPAFQNEMGIAALRRVLTAYAFRNPNIGYCQAMN-IVTSVLL 611
Query: 321 VFLSE 325
++ E
Sbjct: 612 LYAKE 616
>gi|167614488 TBC1 domain family, member 10B [Homo sapiens]
Length = 808
Score = 42.7 bits (99), Expect = 8e-04
Identities = 34/147 (23%), Positives = 52/147 (35%), Gaps = 25/147 (17%)
Query: 288 QEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFLSEYVEEDVENFDVTNLSQDMLRSI 347
Q+ RIL + I P GY Q P V L E
Sbjct: 425 QQDLYRILKAYTIYRPDEGYCQA----QAPVAAVLLMHMPAEQ----------------- 463
Query: 348 EADSFWCMSKLLDG-IQDNYTFAQPGIQKKVKALEELVSRIDEQVHNHFRRYEVEYLQFA 406
+FWC+ ++ D + Y+ IQ + L+ R H H RR ++ + +
Sbjct: 464 ---AFWCLVQICDKYLPGYYSAGLEAIQLDGEIFFALLRRASPLAHRHLRRQRIDPVLYM 520
Query: 407 FRWMNNLLMRELPLRCTIRLWDTYQSE 433
W + R LP +R+WD + E
Sbjct: 521 TEWFMCIFARTLPWASVLRVWDMFFCE 547
>gi|7661864 USP6 N-terminal like isoform 1 [Homo sapiens]
Length = 828
Score = 42.4 bits (98), Expect = 0.001
Identities = 46/234 (19%), Positives = 88/234 (37%), Gaps = 44/234 (18%)
Query: 208 WPGVPREVRPITWRLLSGYLPANTERRKLTLQRKREEYFGFIEQYYDSRNEEHHQDTYRQ 267
+ G+P ++R W LL E R L + K RQ
Sbjct: 98 YKGIPLQLRGEVWALLLEIPKMKEETRDLYSKLKHRA--------------RGCSPDIRQ 143
Query: 268 IHIDIPRTNPLIPLFQQP--LVQEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFLSE 325
I +D+ RT +F+ + Q+ +L ++I + GY QG++ +T +++++E
Sbjct: 144 IDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMSQ-ITALLLMYMNE 202
Query: 326 YVEEDVENFDVTNLSQDMLRSIEADSFWCMSKLLDGIQDN-YTFAQPGIQKKVKALE--- 381
D+FW + KL G + + F G K ++ E
Sbjct: 203 -----------------------EDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQEHHE 239
Query: 382 ELVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMRELPLRCTIRLWDTYQSEPE 435
+++++ ++ H E+ + +W + P +R+WD Y E E
Sbjct: 240 KILNKFLSKLKQHLDSQEIYTSFYTMKWFFQCFLDRTPFTLNLRIWDIYIFEGE 293
>gi|122937432 USP6 N-terminal like isoform 2 [Homo sapiens]
Length = 845
Score = 42.4 bits (98), Expect = 0.001
Identities = 46/234 (19%), Positives = 88/234 (37%), Gaps = 44/234 (18%)
Query: 208 WPGVPREVRPITWRLLSGYLPANTERRKLTLQRKREEYFGFIEQYYDSRNEEHHQDTYRQ 267
+ G+P ++R W LL E R L + K RQ
Sbjct: 115 YKGIPLQLRGEVWALLLEIPKMKEETRDLYSKLKHRA--------------RGCSPDIRQ 160
Query: 268 IHIDIPRTNPLIPLFQQP--LVQEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFLSE 325
I +D+ RT +F+ + Q+ +L ++I + GY QG++ +T +++++E
Sbjct: 161 IDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMSQ-ITALLLMYMNE 219
Query: 326 YVEEDVENFDVTNLSQDMLRSIEADSFWCMSKLLDGIQDN-YTFAQPGIQKKVKALE--- 381
D+FW + KL G + + F G K ++ E
Sbjct: 220 -----------------------EDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQEHHE 256
Query: 382 ELVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMRELPLRCTIRLWDTYQSEPE 435
+++++ ++ H E+ + +W + P +R+WD Y E E
Sbjct: 257 KILNKFLSKLKQHLDSQEIYTSFYTMKWFFQCFLDRTPFTLNLRIWDIYIFEGE 310
>gi|148612875 RUN and TBC1 domain containing 2 isoform 4 [Homo
sapiens]
Length = 1032
Score = 41.2 bits (95), Expect = 0.002
Identities = 39/201 (19%), Positives = 80/201 (39%), Gaps = 29/201 (14%)
Query: 296 FIWAIRHPASGYVQGINDLVTPFFVVFLSEYVEEDVENFDVTNLSQDMLRSIEADSFWCM 355
+IW +H GYVQG+ DL+ P V+ EA +F C
Sbjct: 852 YIW--QHIEIGYVQGMCDLLAPLLVIL-----------------------DDEALAFSCF 886
Query: 356 SKLLDGIQDNYTFAQPGIQKKVKALEELVSRIDEQVHNHFRRY-EVEYLQFAFRWMNNLL 414
++L+ + N+ + + L+ +D ++ + + + F +RW
Sbjct: 887 TELMKRMNQNFPHG-GAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDF 945
Query: 415 MRELPLRCTIRLWDT-YQSEPEGFSHFHLYVCAAFLIKWRKEILDEE-DFQGLLMLLQNL 472
REL +W+T + ++ +H+ L++ A + +R IL+ DF ++ +
Sbjct: 946 KRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKFFNEM 1005
Query: 473 PTIHWGNEEIGLLLAEAYRLK 493
H + + L Y+++
Sbjct: 1006 AERHNTKQVLKLARDLVYKVQ 1026
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.406
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,398,112
Number of Sequences: 37866
Number of extensions: 865382
Number of successful extensions: 2544
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 33
Number of HSP's successfully gapped in prelim test: 31
Number of HSP's that attempted gapping in prelim test: 2433
Number of HSP's gapped (non-prelim): 91
length of query: 505
length of database: 18,247,518
effective HSP length: 107
effective length of query: 398
effective length of database: 14,195,856
effective search space: 5649950688
effective search space used: 5649950688
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.