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Search of human proteins with 39752673
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|39752673 SH3 and cysteine rich domain 2 [Homo sapiens]
(411 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|39752673 SH3 and cysteine rich domain 2 [Homo sapiens] 845 0.0
gi|4507247 SH3 and cysteine rich domain [Homo sapiens] 308 8e-84
gi|21450838 SH3 and cysteine rich domain 3 [Homo sapiens] 209 5e-54
gi|120659787 protein kinase D2 isoform B [Homo sapiens] 59 8e-09
gi|120659785 protein kinase D2 isoform A [Homo sapiens] 59 8e-09
gi|120659782 protein kinase D2 isoform A [Homo sapiens] 59 8e-09
gi|19923468 protein kinase D2 isoform A [Homo sapiens] 59 8e-09
gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo ... 57 2e-08
gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo ... 57 2e-08
gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ... 57 2e-08
gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ... 57 2e-08
gi|227430338 SH3 domain containing, Ysc84-like 1 isoform 2 [Homo... 55 9e-08
gi|11321634 CD2-associated protein [Homo sapiens] 55 1e-07
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 54 3e-07
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 54 3e-07
gi|227430336 SH3 domain containing, Ysc84-like 1 isoform 1 [Homo... 54 3e-07
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 54 3e-07
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 54 3e-07
gi|194294525 intersectin 2 isoform 2 [Homo sapiens] 54 3e-07
gi|4507249 signal transducing adaptor molecule 1 [Homo sapiens] 53 4e-07
gi|20357552 cortactin isoform a [Homo sapiens] 53 6e-07
gi|20357556 cortactin isoform b [Homo sapiens] 53 6e-07
gi|188219625 signal transducing adaptor molecule 2 [Homo sapiens] 52 7e-07
gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens] 52 7e-07
gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Hom... 51 2e-06
gi|45359859 growth factor receptor-bound protein 2 isoform 2 [Ho... 51 2e-06
gi|115529463 protein kinase D1 [Homo sapiens] 51 2e-06
gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Ho... 51 2e-06
gi|120587025 SH3 and multiple ankyrin repeat domains 1 [Homo sap... 51 2e-06
gi|67514036 SH3-domain kinase binding protein 1 isoform b [Homo ... 50 4e-06
>gi|39752673 SH3 and cysteine rich domain 2 [Homo sapiens]
Length = 411
Score = 845 bits (2184), Expect = 0.0
Identities = 411/411 (100%), Positives = 411/411 (100%)
Query: 1 MTEMSEKENEPDDAATHSPPGTVSALQETKLQRFKRSLSLKTILRSKSLENFFLRSGSEL 60
MTEMSEKENEPDDAATHSPPGTVSALQETKLQRFKRSLSLKTILRSKSLENFFLRSGSEL
Sbjct: 1 MTEMSEKENEPDDAATHSPPGTVSALQETKLQRFKRSLSLKTILRSKSLENFFLRSGSEL 60
Query: 61 KCPTEVLLTPPTPLPPPSPPPTASDRGLATPSPSPCPVPRPLAALKPVRLHSFQEHVFKR 120
KCPTEVLLTPPTPLPPPSPPPTASDRGLATPSPSPCPVPRPLAALKPVRLHSFQEHVFKR
Sbjct: 61 KCPTEVLLTPPTPLPPPSPPPTASDRGLATPSPSPCPVPRPLAALKPVRLHSFQEHVFKR 120
Query: 121 ASPCELCHQLIVGNSKQGLRCKMCKVSVHLWCSEEISHQQCPGKTSTSFRRNFSSPLLVH 180
ASPCELCHQLIVGNSKQGLRCKMCKVSVHLWCSEEISHQQCPGKTSTSFRRNFSSPLLVH
Sbjct: 121 ASPCELCHQLIVGNSKQGLRCKMCKVSVHLWCSEEISHQQCPGKTSTSFRRNFSSPLLVH 180
Query: 181 EPPPVCATSKESPPTGDSGKVDPVYETLRYGTSLALMNRSSFSSTSESPTRSLSERDELT 240
EPPPVCATSKESPPTGDSGKVDPVYETLRYGTSLALMNRSSFSSTSESPTRSLSERDELT
Sbjct: 181 EPPPVCATSKESPPTGDSGKVDPVYETLRYGTSLALMNRSSFSSTSESPTRSLSERDELT 240
Query: 241 EDGEGSIRSSEEGPGDSASPVFTAPAESEGPGPEEKSPGQQLPKATLRKDVGPMYSYVAL 300
EDGEGSIRSSEEGPGDSASPVFTAPAESEGPGPEEKSPGQQLPKATLRKDVGPMYSYVAL
Sbjct: 241 EDGEGSIRSSEEGPGDSASPVFTAPAESEGPGPEEKSPGQQLPKATLRKDVGPMYSYVAL 300
Query: 301 YKFLPQENNDLALQPGDRIMLVDDSNEDWWKGKIGDRVGFFPANFVQRVRPGENVWRCCQ 360
YKFLPQENNDLALQPGDRIMLVDDSNEDWWKGKIGDRVGFFPANFVQRVRPGENVWRCCQ
Sbjct: 301 YKFLPQENNDLALQPGDRIMLVDDSNEDWWKGKIGDRVGFFPANFVQRVRPGENVWRCCQ 360
Query: 361 PFSGNKEQGYMSLKENQICVGVGRSKDADGFIRVSSGKKRGLVPVDALTEI 411
PFSGNKEQGYMSLKENQICVGVGRSKDADGFIRVSSGKKRGLVPVDALTEI
Sbjct: 361 PFSGNKEQGYMSLKENQICVGVGRSKDADGFIRVSSGKKRGLVPVDALTEI 411
>gi|4507247 SH3 and cysteine rich domain [Homo sapiens]
Length = 402
Score = 308 bits (788), Expect = 8e-84
Identities = 188/406 (46%), Positives = 251/406 (61%), Gaps = 41/406 (10%)
Query: 19 PPGTVS-ALQETKLQRFKRSLSLKT-ILRSKSLENFFLRSGSELKCPTEVLLTPPTPLPP 76
PP S + QE+KLQ+ KRSLS KT LRSKS +NFF R+ SE ++ +P
Sbjct: 25 PPSPASTSSQESKLQKLKRSLSFKTKSLRSKSADNFFQRTNSEDMKLQAHMVAEISPSSS 84
Query: 77 PSPPPTASDRGLATPSPSPCPVPRPLAALKP-VRLHSFQEHVFKRASPCELCHQLIVG-N 134
P P P G T +P+ A L P + H+FQE++FK+ + C++C+ +IVG N
Sbjct: 85 PLPAP-----GSLTSTPA-------RAGLHPGGKAHAFQEYIFKKPTFCDVCNHMIVGTN 132
Query: 135 SKQGLRCKMCKVSVHLWCSEEISHQQCPGKTSTSFRRNFSSPLLVHEPPPVCATSKESPP 194
+K GLRCK CK+S+H C++ ++ Q+C GK FRR +SSPLL+HE KE P
Sbjct: 133 AKHGLRCKACKMSIHHKCTDGLAPQRCMGKLPKGFRRYYSSPLLIHEQ---FGCIKEVMP 189
Query: 195 TGDSGKVDPVYETLRYGTSLA-LMNRSSFSSTSESPTR-SLSERDELTEDGEGSIRSSEE 252
KVDPVYETLR+GTSLA + S S S+SP R S S+ E+ E+
Sbjct: 190 IACGNKVDPVYETLRFGTSLAQRTKKGSSGSGSDSPHRTSTSDLVEVPEEA--------N 241
Query: 253 GPGDS------ASPVFTAPAESEGPGPEEKSPGQQL-PKATLRKDVGPMYSYVALYKFLP 305
GPG ++ VFT P E + + P + + + +L KD M +YVALYKF+P
Sbjct: 242 GPGGGYDLRKRSNSVFTYP---ENGTDDFRDPAKNINHQGSLSKDPLQMNTYVALYKFVP 298
Query: 306 QENNDLALQPGDRIMLVDDSNEDWWKGKIGDRVGFFPANFVQRVRPGENVWRCCQPFSGN 365
QEN DL ++PGD I L++DSNEDWWKGKI DR+GFFPANFVQR++ E ++RC + F G
Sbjct: 299 QENEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFVQRLQQNEKIFRCVRTFIGC 358
Query: 366 KEQGYMSLKENQICVGVGRSKDADGFIRVSSGKKRGLVPVDALTEI 411
KEQG ++LKENQIC V ++ DGFIRV SGKK+GL+P+D L I
Sbjct: 359 KEQGQITLKENQIC--VSSEEEQDGFIRVLSGKKKGLIPLDVLENI 402
>gi|21450838 SH3 and cysteine rich domain 3 [Homo sapiens]
Length = 364
Score = 209 bits (531), Expect = 5e-54
Identities = 120/317 (37%), Positives = 173/317 (54%), Gaps = 29/317 (9%)
Query: 95 PCPVPRPLAALKPVRLHSFQEHVFKRASPCELCHQLIVGNSKQGLRCKMCKVSVHLWCSE 154
P P P L KP H F++H FK+ C++C ++IV N+K GLRCK CK ++H C
Sbjct: 77 PPPEPPKLVNDKP---HKFKDHFFKKPKFCDVCARMIVLNNKFGLRCKNCKTNIHEHCQS 133
Query: 155 EISHQQCPGKTSTSFRRNFSSPLLVHEPPPVCATSKESPPTGDSGKVDPVYETLRYGTSL 214
+ Q+C GK F R +SSPL ++ C + + + DPV+ETLR G +
Sbjct: 134 YVEMQRCFGKIPPGFHRAYSSPLYSNQQY-ACVKDLSA-----ANRNDPVFETLRTGVIM 187
Query: 215 ALMNRSSFSSTSESPTRSLSERDELTEDGEGSIRSSEEGPGDSASPVFTAPAESEGPGPE 274
A R + ++P ++ E E EEG +P AE + P +
Sbjct: 188 ANKERKKGQADKKNPVAAMMEE-------EPESARPEEGKPQDGNPEGDKKAEKKTPDDK 240
Query: 275 EKSPGQQLPKATLRKDVGPMYSYVALYKFLPQENNDLALQPGDRIMLVDDSNEDWWKGKI 334
K PG Q + +VALY+F E +DL PG++I ++DDSNE+WW+GKI
Sbjct: 241 HKQPGFQ-----------QSHYFVALYRFKALEKDDLDFPPGEKITVIDDSNEEWWRGKI 289
Query: 335 GDRVGFFPANFVQRVRPGENVWRCCQPFSGNKEQGYMSLKENQICVGVGRSKDADGFIRV 394
G++VGFFP NF+ RVR GE V R + F GN+E G ++LK++QI V G +A G+++V
Sbjct: 290 GEKVGFFPPNFIIRVRAGERVHRVTRSFVGNREIGQITLKKDQIVVQKG--DEAGGYVKV 347
Query: 395 SSGKKRGLVPVDALTEI 411
+G+K GL P D L EI
Sbjct: 348 YTGRKVGLFPTDFLEEI 364
>gi|120659787 protein kinase D2 isoform B [Homo sapiens]
Length = 721
Score = 58.9 bits (141), Expect = 8e-09
Identities = 38/130 (29%), Positives = 63/130 (48%), Gaps = 5/130 (3%)
Query: 35 KRSLSLKTILRSKSLENFFLRSGSELKCPTEVLLTPPTPLPPPSPPPTASDRGLATPSPS 94
KR LS ++ S+ L + L C E L T L P PP ++S ++ +
Sbjct: 36 KRRLSSTSLASGHSVR---LGTSESLPCTAEELSRSTTELLPRRPPSSSSSSSASSYTGR 92
Query: 95 PCPVPRPLAALKPVRLHSFQEHVFKRASPCELCHQLIVGNSKQGLRCKMCKVSVHLWCSE 154
P + + L + V H+F H + R + C+ C +L+ G +QGL+CK CK + H C+
Sbjct: 93 PIELDKMLLSKVKVP-HTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCKFNCHKRCAT 151
Query: 155 EISHQQCPGK 164
+ + C G+
Sbjct: 152 RVPN-DCLGE 160
Score = 30.8 bits (68), Expect = 2.3
Identities = 28/99 (28%), Positives = 40/99 (40%), Gaps = 14/99 (14%)
Query: 130 LIVGNSKQGLRCKMCKVSVHLWCSEEISHQQCPGKTSTSFRRNFSSPLLVHEPPPVCATS 189
++ G +QGL+C C ++ H C+ I P S + +R SS L TS
Sbjct: 1 MLFGLVRQGLKCDGCGLNYHKRCAFSI-----PNNCSGARKRRLSSTSLASGHSVRLGTS 55
Query: 190 KESPPTGDSGKVDPVYETLRYGTSLALMNRSSFSSTSES 228
+ P T E L T+ L R SS+S S
Sbjct: 56 ESLPCTA---------EELSRSTTELLPRRPPSSSSSSS 85
>gi|120659785 protein kinase D2 isoform A [Homo sapiens]
Length = 878
Score = 58.9 bits (141), Expect = 8e-09
Identities = 38/130 (29%), Positives = 63/130 (48%), Gaps = 5/130 (3%)
Query: 35 KRSLSLKTILRSKSLENFFLRSGSELKCPTEVLLTPPTPLPPPSPPPTASDRGLATPSPS 94
KR LS ++ S+ L + L C E L T L P PP ++S ++ +
Sbjct: 193 KRRLSSTSLASGHSVR---LGTSESLPCTAEELSRSTTELLPRRPPSSSSSSSASSYTGR 249
Query: 95 PCPVPRPLAALKPVRLHSFQEHVFKRASPCELCHQLIVGNSKQGLRCKMCKVSVHLWCSE 154
P + + L + V H+F H + R + C+ C +L+ G +QGL+CK CK + H C+
Sbjct: 250 PIELDKMLLSKVKVP-HTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCKFNCHKRCAT 308
Query: 155 EISHQQCPGK 164
+ + C G+
Sbjct: 309 RVPN-DCLGE 317
Score = 43.9 bits (102), Expect = 3e-04
Identities = 33/121 (27%), Positives = 52/121 (42%), Gaps = 14/121 (11%)
Query: 108 VRLHSFQEHVFKRASPCELCHQLIVGNSKQGLRCKMCKVSVHLWCSEEISHQQCPGKTST 167
+R H+ H ++ + C+ C +++ G +QGL+C C ++ H C+ I P S
Sbjct: 136 IRPHALTVHSYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYHKRCAFSI-----PNNCSG 190
Query: 168 SFRRNFSSPLLVHEPPPVCATSKESPPTGDSGKVDPVYETLRYGTSLALMNRSSFSSTSE 227
+ +R SS L TS+ P T E L T+ L R SS+S
Sbjct: 191 ARKRRLSSTSLASGHSVRLGTSESLPCTA---------EELSRSTTELLPRRPPSSSSSS 241
Query: 228 S 228
S
Sbjct: 242 S 242
>gi|120659782 protein kinase D2 isoform A [Homo sapiens]
Length = 878
Score = 58.9 bits (141), Expect = 8e-09
Identities = 38/130 (29%), Positives = 63/130 (48%), Gaps = 5/130 (3%)
Query: 35 KRSLSLKTILRSKSLENFFLRSGSELKCPTEVLLTPPTPLPPPSPPPTASDRGLATPSPS 94
KR LS ++ S+ L + L C E L T L P PP ++S ++ +
Sbjct: 193 KRRLSSTSLASGHSVR---LGTSESLPCTAEELSRSTTELLPRRPPSSSSSSSASSYTGR 249
Query: 95 PCPVPRPLAALKPVRLHSFQEHVFKRASPCELCHQLIVGNSKQGLRCKMCKVSVHLWCSE 154
P + + L + V H+F H + R + C+ C +L+ G +QGL+CK CK + H C+
Sbjct: 250 PIELDKMLLSKVKVP-HTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCKFNCHKRCAT 308
Query: 155 EISHQQCPGK 164
+ + C G+
Sbjct: 309 RVPN-DCLGE 317
Score = 43.9 bits (102), Expect = 3e-04
Identities = 33/121 (27%), Positives = 52/121 (42%), Gaps = 14/121 (11%)
Query: 108 VRLHSFQEHVFKRASPCELCHQLIVGNSKQGLRCKMCKVSVHLWCSEEISHQQCPGKTST 167
+R H+ H ++ + C+ C +++ G +QGL+C C ++ H C+ I P S
Sbjct: 136 IRPHALTVHSYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYHKRCAFSI-----PNNCSG 190
Query: 168 SFRRNFSSPLLVHEPPPVCATSKESPPTGDSGKVDPVYETLRYGTSLALMNRSSFSSTSE 227
+ +R SS L TS+ P T E L T+ L R SS+S
Sbjct: 191 ARKRRLSSTSLASGHSVRLGTSESLPCTA---------EELSRSTTELLPRRPPSSSSSS 241
Query: 228 S 228
S
Sbjct: 242 S 242
>gi|19923468 protein kinase D2 isoform A [Homo sapiens]
Length = 878
Score = 58.9 bits (141), Expect = 8e-09
Identities = 38/130 (29%), Positives = 63/130 (48%), Gaps = 5/130 (3%)
Query: 35 KRSLSLKTILRSKSLENFFLRSGSELKCPTEVLLTPPTPLPPPSPPPTASDRGLATPSPS 94
KR LS ++ S+ L + L C E L T L P PP ++S ++ +
Sbjct: 193 KRRLSSTSLASGHSVR---LGTSESLPCTAEELSRSTTELLPRRPPSSSSSSSASSYTGR 249
Query: 95 PCPVPRPLAALKPVRLHSFQEHVFKRASPCELCHQLIVGNSKQGLRCKMCKVSVHLWCSE 154
P + + L + V H+F H + R + C+ C +L+ G +QGL+CK CK + H C+
Sbjct: 250 PIELDKMLLSKVKVP-HTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCKFNCHKRCAT 308
Query: 155 EISHQQCPGK 164
+ + C G+
Sbjct: 309 RVPN-DCLGE 317
Score = 43.9 bits (102), Expect = 3e-04
Identities = 33/121 (27%), Positives = 52/121 (42%), Gaps = 14/121 (11%)
Query: 108 VRLHSFQEHVFKRASPCELCHQLIVGNSKQGLRCKMCKVSVHLWCSEEISHQQCPGKTST 167
+R H+ H ++ + C+ C +++ G +QGL+C C ++ H C+ I P S
Sbjct: 136 IRPHALTVHSYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYHKRCAFSI-----PNNCSG 190
Query: 168 SFRRNFSSPLLVHEPPPVCATSKESPPTGDSGKVDPVYETLRYGTSLALMNRSSFSSTSE 227
+ +R SS L TS+ P T E L T+ L R SS+S
Sbjct: 191 ARKRRLSSTSLASGHSVRLGTSESLPCTA---------EELSRSTTELLPRRPPSSSSSS 241
Query: 228 S 228
S
Sbjct: 242 S 242
>gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo
sapiens]
Length = 824
Score = 57.4 bits (137), Expect = 2e-08
Identities = 81/305 (26%), Positives = 124/305 (40%), Gaps = 84/305 (27%)
Query: 67 LLTPPTPLP--PPSPPPTASDRGLATPSPSPCP---VPRPLA---ALKPVR-----LHSF 113
L T PTP+P P P ++S G T SPSP P P P + AL P R L
Sbjct: 410 LPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPTPSSRAPALSPTRPPKKPLDYV 469
Query: 114 QEH---VFKRASPCELCHQLIVGNSKQGLRCKMCKVSVHLWCSEEISHQQCPGKTSTSFR 170
Q+H VF AS L + + L M S+ ++ FR
Sbjct: 470 QDHSSGVFNEAS-------LYQSSIDRSLERPMSSASM-----------------ASDFR 505
Query: 171 RNFSSPLLVHEPPPVC--ATSKESPPTGDSGKVDPVYETLRYGTSLALMNRSSFSSTSES 228
+ S V P + + S+ SP G+VD G+S L +S SS+ S
Sbjct: 506 KRRKSEPAVGPPRGLGDQSASRTSP-----GRVDLP------GSSTTL-TKSFTSSSPSS 553
Query: 229 PTRSLSERDELTEDGEGSIRSSEEGPGDSASPVFTAPAESEGPGPEEKSPGQQLPKATLR 288
P+R+ + S S+ G SA P E G +EK P +
Sbjct: 554 PSRAKDR------ESPRSYSSTLTDMGRSA------PRERRGTPEKEKLPAK-------- 593
Query: 289 KDVGPMYSYVALYKFLPQENNDLALQPGDRIMLVDDSNEDWWKGKIGDRVGFFPANFVQR 348
A+Y F Q + +L+ + GD + ++ +++W++G+ RVG FP ++V++
Sbjct: 594 ----------AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEK 643
Query: 349 VRPGE 353
+ P E
Sbjct: 644 LTPPE 648
Score = 34.3 bits (77), Expect = 0.21
Identities = 20/71 (28%), Positives = 36/71 (50%), Gaps = 2/71 (2%)
Query: 281 QLPKATLRKDVGPMYSYVALYKFLPQENNDLALQPGDRIMLVDDSNEDWWKG--KIGDRV 338
Q P T G + ALY + P+ ++L L+ D I +++ ++ W+ G +
Sbjct: 754 QRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFF 813
Query: 339 GFFPANFVQRV 349
G FP N+V+R+
Sbjct: 814 GTFPGNYVKRL 824
>gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo
sapiens]
Length = 731
Score = 57.4 bits (137), Expect = 2e-08
Identities = 81/305 (26%), Positives = 124/305 (40%), Gaps = 84/305 (27%)
Query: 67 LLTPPTPLP--PPSPPPTASDRGLATPSPSPCP---VPRPLA---ALKPVR-----LHSF 113
L T PTP+P P P ++S G T SPSP P P P + AL P R L
Sbjct: 317 LPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPTPSSRAPALSPTRPPKKPLDYV 376
Query: 114 QEH---VFKRASPCELCHQLIVGNSKQGLRCKMCKVSVHLWCSEEISHQQCPGKTSTSFR 170
Q+H VF AS L + + L M S+ ++ FR
Sbjct: 377 QDHSSGVFNEAS-------LYQSSIDRSLERPMSSASM-----------------ASDFR 412
Query: 171 RNFSSPLLVHEPPPVC--ATSKESPPTGDSGKVDPVYETLRYGTSLALMNRSSFSSTSES 228
+ S V P + + S+ SP G+VD G+S L +S SS+ S
Sbjct: 413 KRRKSEPAVGPPRGLGDQSASRTSP-----GRVDLP------GSSTTL-TKSFTSSSPSS 460
Query: 229 PTRSLSERDELTEDGEGSIRSSEEGPGDSASPVFTAPAESEGPGPEEKSPGQQLPKATLR 288
P+R+ + S S+ G SA P E G +EK P +
Sbjct: 461 PSRAKDR------ESPRSYSSTLTDMGRSA------PRERRGTPEKEKLPAK-------- 500
Query: 289 KDVGPMYSYVALYKFLPQENNDLALQPGDRIMLVDDSNEDWWKGKIGDRVGFFPANFVQR 348
A+Y F Q + +L+ + GD + ++ +++W++G+ RVG FP ++V++
Sbjct: 501 ----------AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEK 550
Query: 349 VRPGE 353
+ P E
Sbjct: 551 LTPPE 555
Score = 34.3 bits (77), Expect = 0.21
Identities = 20/71 (28%), Positives = 36/71 (50%), Gaps = 2/71 (2%)
Query: 281 QLPKATLRKDVGPMYSYVALYKFLPQENNDLALQPGDRIMLVDDSNEDWWKG--KIGDRV 338
Q P T G + ALY + P+ ++L L+ D I +++ ++ W+ G +
Sbjct: 661 QRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFF 720
Query: 339 GFFPANFVQRV 349
G FP N+V+R+
Sbjct: 721 GTFPGNYVKRL 731
>gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
isoform 2 [Homo sapiens]
Length = 2472
Score = 57.4 bits (137), Expect = 2e-08
Identities = 26/81 (32%), Positives = 52/81 (64%), Gaps = 4/81 (4%)
Query: 298 VALYKFLPQENNDLALQPGDRIMLVDDSNEDWWKGKIGDRVGFFPANFVQRVRPGENVWR 357
+ALY + + ++ ++ GD + L++ +N+DWWK ++ DR GF PA +V+++ P ++ R
Sbjct: 973 LALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSASR 1032
Query: 358 CCQPFSGNKEQGYMSLKENQI 378
+ +EQG ++L++ QI
Sbjct: 1033 ----ENLLEEQGSIALRQEQI 1049
>gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
isoform 1 [Homo sapiens]
Length = 2477
Score = 57.4 bits (137), Expect = 2e-08
Identities = 26/81 (32%), Positives = 52/81 (64%), Gaps = 4/81 (4%)
Query: 298 VALYKFLPQENNDLALQPGDRIMLVDDSNEDWWKGKIGDRVGFFPANFVQRVRPGENVWR 357
+ALY + + ++ ++ GD + L++ +N+DWWK ++ DR GF PA +V+++ P ++ R
Sbjct: 973 LALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSASR 1032
Query: 358 CCQPFSGNKEQGYMSLKENQI 378
+ +EQG ++L++ QI
Sbjct: 1033 ----ENLLEEQGSIALRQEQI 1049
>gi|227430338 SH3 domain containing, Ysc84-like 1 isoform 2 [Homo
sapiens]
Length = 323
Score = 55.5 bits (132), Expect = 9e-08
Identities = 29/76 (38%), Positives = 43/76 (56%), Gaps = 3/76 (3%)
Query: 273 PEEKSPGQQLPKATLRKDVGPMYSYVALYKFLPQENNDLALQPGDRIMLVD--DSNEDWW 330
P++ S QL + + ++ ALY F Q+ DL Q GDRI ++ DS+ DWW
Sbjct: 246 PQQSSAPVQLNSGS-QSNLNQPIEVTALYSFEGQQPGDLNFQAGDRITVISKTDSHFDWW 304
Query: 331 KGKIGDRVGFFPANFV 346
+GK+ + G FPAN+V
Sbjct: 305 EGKLRGQTGIFPANYV 320
>gi|11321634 CD2-associated protein [Homo sapiens]
Length = 639
Score = 55.1 bits (131), Expect = 1e-07
Identities = 34/126 (26%), Positives = 61/126 (48%), Gaps = 15/126 (11%)
Query: 229 PTRSLSERDELTEDGEGSIRSSEEGPGDSASPV-----FTAPAESEGPGPEEKSPGQQLP 283
P + E TE + S+ E G+ AS V + PA P P+ K+ ++
Sbjct: 50 PDNFVKEIKRETEFKDDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTK 109
Query: 284 KATLRKDVGPMYSYVALYKFLPQENNDLALQPGDRIMLVDDSNEDWWKGKIGDRVGFFPA 343
K + L++++PQ ++L L+ GD I + ++ E WW G + +++G FP+
Sbjct: 110 KRQCK----------VLFEYIPQNEDELELKVGDIIDINEEVEEGWWSGTLNNKLGLFPS 159
Query: 344 NFVQRV 349
NFV+ +
Sbjct: 160 NFVKEL 165
Score = 36.2 bits (82), Expect = 0.056
Identities = 27/142 (19%), Positives = 56/142 (39%), Gaps = 21/142 (14%)
Query: 229 PTRSLSERDELTEDGEGSIRSSEEGPGDSASPVF----------TAPAESEGPGPEE--- 275
PT + ++E GS+ ++ G +F T+ +E+E PE+
Sbjct: 187 PTSPIPSLGNVSETASGSVTQPKKIRGIGFGDIFKEGSVKLRTRTSSSETEEKKPEKPLI 246
Query: 276 ------KSPGQQLPKATLRKDVGPMYSYVALYKFLPQENNDLALQPGDRIMLVDDSNED- 328
K+ ++ K + L+ + ++L + G+ I L+ +
Sbjct: 247 LQSLGPKTQSVEITKTDTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEA 306
Query: 329 -WWKGKIGDRVGFFPANFVQRV 349
WW+G++ + G FP NF ++
Sbjct: 307 GWWRGELNGKEGVFPDNFAVQI 328
Score = 35.8 bits (81), Expect = 0.073
Identities = 17/58 (29%), Positives = 32/58 (55%), Gaps = 1/58 (1%)
Query: 294 MYSYVALYKFLPQENNDLALQPGDRIMLVDDSNEDWW-KGKIGDRVGFFPANFVQRVR 350
M Y+ Y + +++L ++ G+ I V E+ W +G++ R G FP NFV+ ++
Sbjct: 1 MVDYIVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIK 58
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 53.9 bits (128), Expect = 3e-07
Identities = 41/168 (24%), Positives = 72/168 (42%), Gaps = 9/168 (5%)
Query: 183 PPVCATSKESPPTGDSGKVDPVYETLRYGTSLALMNRSSFSSTSESPTRSLSERDELTED 242
P S SP G KV+ + Y N +F+ ++ ++ E+ ++
Sbjct: 895 PATATGSSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFN---KNDVITVLEQQDMWWF 951
Query: 243 GEGSIRSSEEGPGDSASPVFTAP---AESEGPGPEEKSPGQQLPKATLRKDVGPMYSYVA 299
GE ++ + S + + P + S G E + + K V ++A
Sbjct: 952 GE--VQGQKGWFPKSYVKLISGPIRKSTSMDSGSSESPASLKRVASPAAKPVVSGEEFIA 1009
Query: 300 LYKFLPQENNDLALQPGDRIMLVDDSNEDWWKGKIGDRVGFFPANFVQ 347
+Y + E DL Q GD ++LV + DWW G +GD+ G FP+N+V+
Sbjct: 1010 MYTYESSEQGDLTFQQGD-VILVTKKDGDWWTGTVGDKAGVFPSNYVR 1056
Score = 51.6 bits (122), Expect = 1e-06
Identities = 23/77 (29%), Positives = 45/77 (58%), Gaps = 4/77 (5%)
Query: 271 PGPEEKSPGQQLPKATLRKDVGPMYSYVALYKFLPQENNDLALQPGDRIMLVDDSNEDWW 330
PG + +P + PK+T + + + +Y + Q +++LA G I +++ + DWW
Sbjct: 1138 PGTSKITPTEP-PKSTA---LAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWW 1193
Query: 331 KGKIGDRVGFFPANFVQ 347
KG++ +VG FP+N+V+
Sbjct: 1194 KGEVNGQVGLFPSNYVK 1210
Score = 45.4 bits (106), Expect = 9e-05
Identities = 31/127 (24%), Positives = 61/127 (48%), Gaps = 9/127 (7%)
Query: 235 ERDELTEDGEGSIRSSEEGPGDSASPVFTAPAESEGPGPEEK-SPGQQLPKATLRKDVGP 293
+R+E + +G + +E D +F E P + S ++ P ++
Sbjct: 683 KREESVKKKDGEEKGKQEAQ-DKLGRLFHQHQEPAKPAVQAPWSTAEKGPLTISAQENVK 741
Query: 294 MYSYVALYKFLPQENNDLALQPGDRIML----VDDSNED---WWKGKIGDRVGFFPANFV 346
+ Y ALY F + ++++ +QPGD +M+ VD+S W G++ + G+FPAN+
Sbjct: 742 VVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYA 801
Query: 347 QRVRPGE 353
+++ E
Sbjct: 802 EKIPENE 808
Score = 37.7 bits (86), Expect = 0.019
Identities = 17/47 (36%), Positives = 28/47 (59%), Gaps = 5/47 (10%)
Query: 311 LALQPGDRIMLVDDSNEDWWKGKIGDR-----VGFFPANFVQRVRPG 352
L L PG I++ + WW+G++ R +G+FPAN+V+ + PG
Sbjct: 1093 LTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPG 1139
Score = 35.8 bits (81), Expect = 0.073
Identities = 37/143 (25%), Positives = 56/143 (39%), Gaps = 33/143 (23%)
Query: 218 NRSSFSSTSESPTRSLSERDE---------LTEDGEGSIRSSEEGPGDSASPVFTAPAES 268
N + FSST + T E D LT G +R SA TA S
Sbjct: 849 NWADFSSTWPTSTNEKPETDNWDAWAAQPSLTVPSAGQLRQR------SAFTPATATGSS 902
Query: 269 EGP--GPEEKSPGQQLPKATLRKDVGPMYSYVALYKFLPQENNDLALQPGDRIMLVDDSN 326
P G EK G Q ALY + +++N L D ++ V +
Sbjct: 903 PSPVLGQGEKVEGLQAQ---------------ALYPWRAKKDNHLNFNKND-VITVLEQQ 946
Query: 327 EDWWKGKIGDRVGFFPANFVQRV 349
+ WW G++ + G+FP ++V+ +
Sbjct: 947 DMWWFGEVQGQKGWFPKSYVKLI 969
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 53.9 bits (128), Expect = 3e-07
Identities = 41/168 (24%), Positives = 72/168 (42%), Gaps = 9/168 (5%)
Query: 183 PPVCATSKESPPTGDSGKVDPVYETLRYGTSLALMNRSSFSSTSESPTRSLSERDELTED 242
P S SP G KV+ + Y N +F+ ++ ++ E+ ++
Sbjct: 895 PATATGSSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFN---KNDVITVLEQQDMWWF 951
Query: 243 GEGSIRSSEEGPGDSASPVFTAP---AESEGPGPEEKSPGQQLPKATLRKDVGPMYSYVA 299
GE ++ + S + + P + S G E + + K V ++A
Sbjct: 952 GE--VQGQKGWFPKSYVKLISGPIRKSTSMDSGSSESPASLKRVASPAAKPVVSGEEFIA 1009
Query: 300 LYKFLPQENNDLALQPGDRIMLVDDSNEDWWKGKIGDRVGFFPANFVQ 347
+Y + E DL Q GD ++LV + DWW G +GD+ G FP+N+V+
Sbjct: 1010 MYTYESSEQGDLTFQQGD-VILVTKKDGDWWTGTVGDKAGVFPSNYVR 1056
Score = 51.6 bits (122), Expect = 1e-06
Identities = 23/77 (29%), Positives = 45/77 (58%), Gaps = 4/77 (5%)
Query: 271 PGPEEKSPGQQLPKATLRKDVGPMYSYVALYKFLPQENNDLALQPGDRIMLVDDSNEDWW 330
PG + +P + PK+T + + + +Y + Q +++LA G I +++ + DWW
Sbjct: 1138 PGTSKITPTEP-PKSTA---LAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWW 1193
Query: 331 KGKIGDRVGFFPANFVQ 347
KG++ +VG FP+N+V+
Sbjct: 1194 KGEVNGQVGLFPSNYVK 1210
Score = 45.4 bits (106), Expect = 9e-05
Identities = 31/127 (24%), Positives = 61/127 (48%), Gaps = 9/127 (7%)
Query: 235 ERDELTEDGEGSIRSSEEGPGDSASPVFTAPAESEGPGPEEK-SPGQQLPKATLRKDVGP 293
+R+E + +G + +E D +F E P + S ++ P ++
Sbjct: 683 KREESVKKKDGEEKGKQEAQ-DKLGRLFHQHQEPAKPAVQAPWSTAEKGPLTISAQENVK 741
Query: 294 MYSYVALYKFLPQENNDLALQPGDRIML----VDDSNED---WWKGKIGDRVGFFPANFV 346
+ Y ALY F + ++++ +QPGD +M+ VD+S W G++ + G+FPAN+
Sbjct: 742 VVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYA 801
Query: 347 QRVRPGE 353
+++ E
Sbjct: 802 EKIPENE 808
Score = 37.7 bits (86), Expect = 0.019
Identities = 17/47 (36%), Positives = 28/47 (59%), Gaps = 5/47 (10%)
Query: 311 LALQPGDRIMLVDDSNEDWWKGKIGDR-----VGFFPANFVQRVRPG 352
L L PG I++ + WW+G++ R +G+FPAN+V+ + PG
Sbjct: 1093 LTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPG 1139
Score = 35.8 bits (81), Expect = 0.073
Identities = 37/143 (25%), Positives = 56/143 (39%), Gaps = 33/143 (23%)
Query: 218 NRSSFSSTSESPTRSLSERDE---------LTEDGEGSIRSSEEGPGDSASPVFTAPAES 268
N + FSST + T E D LT G +R SA TA S
Sbjct: 849 NWADFSSTWPTSTNEKPETDNWDAWAAQPSLTVPSAGQLRQR------SAFTPATATGSS 902
Query: 269 EGP--GPEEKSPGQQLPKATLRKDVGPMYSYVALYKFLPQENNDLALQPGDRIMLVDDSN 326
P G EK G Q ALY + +++N L D ++ V +
Sbjct: 903 PSPVLGQGEKVEGLQAQ---------------ALYPWRAKKDNHLNFNKND-VITVLEQQ 946
Query: 327 EDWWKGKIGDRVGFFPANFVQRV 349
+ WW G++ + G+FP ++V+ +
Sbjct: 947 DMWWFGEVQGQKGWFPKSYVKLI 969
>gi|227430336 SH3 domain containing, Ysc84-like 1 isoform 1 [Homo
sapiens]
Length = 342
Score = 53.9 bits (128), Expect = 3e-07
Identities = 25/50 (50%), Positives = 33/50 (66%), Gaps = 2/50 (4%)
Query: 299 ALYKFLPQENNDLALQPGDRIMLVD--DSNEDWWKGKIGDRVGFFPANFV 346
ALY F Q+ DL Q GDRI ++ DS+ DWW+GK+ + G FPAN+V
Sbjct: 290 ALYSFEGQQPGDLNFQAGDRITVISKTDSHFDWWEGKLRGQTGIFPANYV 339
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 53.9 bits (128), Expect = 3e-07
Identities = 32/82 (39%), Positives = 42/82 (51%), Gaps = 6/82 (7%)
Query: 271 PGPEEK-SPGQQLPKATLRKDVGPMYS----YVALYKFLPQENNDLALQPGDRIMLVDDS 325
PG E K + L A +K YS Y+ALY + E DL G+ I LV
Sbjct: 928 PGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEI-LVTQK 986
Query: 326 NEDWWKGKIGDRVGFFPANFVQ 347
+ +WW G IGDR G FP+N+V+
Sbjct: 987 DGEWWTGSIGDRSGIFPSNYVK 1008
Score = 47.4 bits (111), Expect = 2e-05
Identities = 23/88 (26%), Positives = 42/88 (47%), Gaps = 10/88 (11%)
Query: 293 PMYSYVALYKFLPQENNDLALQPGDRIMLVDDSNEDWWKGKIGDRVGFFPANFVQRVRPG 352
P+ +A+Y + ++L+ G I +++ + DWW+G+I G FP+N+V+
Sbjct: 1101 PVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDS 1160
Query: 353 ENVWRCC---------QPFSGNKEQGYM 371
+ + C QP K QGY+
Sbjct: 1161 DPSQQWCADLQTLDTMQPIE-RKRQGYI 1187
Score = 37.7 bits (86), Expect = 0.019
Identities = 20/70 (28%), Positives = 36/70 (51%), Gaps = 4/70 (5%)
Query: 288 RKDVGPMYSYVALYKFLPQENNDLALQPGDRIMLVDDSN---EDWWKGKIGDRVGFFPAN 344
R+ + +Y ALY F + +++++ GD I+ VD+ W G G+FP N
Sbjct: 726 RETASVLVNYRALYPFEARNHDEMSFNSGD-IIQVDEKTVGEPGWLYGSFQGNFGWFPCN 784
Query: 345 FVQRVRPGEN 354
+V+++ EN
Sbjct: 785 YVEKMPSSEN 794
Score = 33.9 bits (76), Expect = 0.28
Identities = 15/54 (27%), Positives = 30/54 (55%), Gaps = 5/54 (9%)
Query: 303 FLPQENNDLALQPGDRIMLVDDSNEDWWKGKIGDR-----VGFFPANFVQRVRP 351
++ + L+L PG I+++ + WW+G++ R G+FPA+ V+ + P
Sbjct: 1037 YVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGP 1090
Score = 33.5 bits (75), Expect = 0.36
Identities = 19/59 (32%), Positives = 33/59 (55%), Gaps = 2/59 (3%)
Query: 299 ALYKFLPQENNDLALQPGDRIMLVDDSNEDWWKGKIGDRVGFFPANFVQRVRPGENVWR 357
AL + +++N L D I+ V + E+WW G++ G+FP ++V ++ PG V R
Sbjct: 878 ALCSWTAKKDNHLNFSKHD-IITVLEQQENWWFGEVHGGRGWFPKSYV-KIIPGSEVKR 934
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 53.9 bits (128), Expect = 3e-07
Identities = 32/82 (39%), Positives = 42/82 (51%), Gaps = 6/82 (7%)
Query: 271 PGPEEK-SPGQQLPKATLRKDVGPMYS----YVALYKFLPQENNDLALQPGDRIMLVDDS 325
PG E K + L A +K YS Y+ALY + E DL G+ I LV
Sbjct: 955 PGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEI-LVTQK 1013
Query: 326 NEDWWKGKIGDRVGFFPANFVQ 347
+ +WW G IGDR G FP+N+V+
Sbjct: 1014 DGEWWTGSIGDRSGIFPSNYVK 1035
Score = 47.4 bits (111), Expect = 2e-05
Identities = 23/88 (26%), Positives = 42/88 (47%), Gaps = 10/88 (11%)
Query: 293 PMYSYVALYKFLPQENNDLALQPGDRIMLVDDSNEDWWKGKIGDRVGFFPANFVQRVRPG 352
P+ +A+Y + ++L+ G I +++ + DWW+G+I G FP+N+V+
Sbjct: 1128 PVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDS 1187
Query: 353 ENVWRCC---------QPFSGNKEQGYM 371
+ + C QP K QGY+
Sbjct: 1188 DPSQQWCADLQTLDTMQPIE-RKRQGYI 1214
Score = 37.7 bits (86), Expect = 0.019
Identities = 20/70 (28%), Positives = 36/70 (51%), Gaps = 4/70 (5%)
Query: 288 RKDVGPMYSYVALYKFLPQENNDLALQPGDRIMLVDDSN---EDWWKGKIGDRVGFFPAN 344
R+ + +Y ALY F + +++++ GD I+ VD+ W G G+FP N
Sbjct: 753 RETASVLVNYRALYPFEARNHDEMSFNSGD-IIQVDEKTVGEPGWLYGSFQGNFGWFPCN 811
Query: 345 FVQRVRPGEN 354
+V+++ EN
Sbjct: 812 YVEKMPSSEN 821
Score = 33.9 bits (76), Expect = 0.28
Identities = 15/54 (27%), Positives = 30/54 (55%), Gaps = 5/54 (9%)
Query: 303 FLPQENNDLALQPGDRIMLVDDSNEDWWKGKIGDR-----VGFFPANFVQRVRP 351
++ + L+L PG I+++ + WW+G++ R G+FPA+ V+ + P
Sbjct: 1064 YVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGP 1117
Score = 33.5 bits (75), Expect = 0.36
Identities = 19/59 (32%), Positives = 33/59 (55%), Gaps = 2/59 (3%)
Query: 299 ALYKFLPQENNDLALQPGDRIMLVDDSNEDWWKGKIGDRVGFFPANFVQRVRPGENVWR 357
AL + +++N L D I+ V + E+WW G++ G+FP ++V ++ PG V R
Sbjct: 905 ALCSWTAKKDNHLNFSKHD-IITVLEQQENWWFGEVHGGRGWFPKSYV-KIIPGSEVKR 961
>gi|194294525 intersectin 2 isoform 2 [Homo sapiens]
Length = 1249
Score = 53.9 bits (128), Expect = 3e-07
Identities = 32/82 (39%), Positives = 42/82 (51%), Gaps = 6/82 (7%)
Query: 271 PGPEEK-SPGQQLPKATLRKDVGPMYS----YVALYKFLPQENNDLALQPGDRIMLVDDS 325
PG E K + L A +K YS Y+ALY + E DL G+ I LV
Sbjct: 955 PGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEI-LVTQK 1013
Query: 326 NEDWWKGKIGDRVGFFPANFVQ 347
+ +WW G IGDR G FP+N+V+
Sbjct: 1014 DGEWWTGSIGDRSGIFPSNYVK 1035
Score = 47.4 bits (111), Expect = 2e-05
Identities = 23/88 (26%), Positives = 42/88 (47%), Gaps = 10/88 (11%)
Query: 293 PMYSYVALYKFLPQENNDLALQPGDRIMLVDDSNEDWWKGKIGDRVGFFPANFVQRVRPG 352
P+ +A+Y + ++L+ G I +++ + DWW+G+I G FP+N+V+
Sbjct: 1128 PVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDS 1187
Query: 353 ENVWRCC---------QPFSGNKEQGYM 371
+ + C QP K QGY+
Sbjct: 1188 DPSQQWCADLQTLDTMQPIE-RKRQGYI 1214
Score = 37.7 bits (86), Expect = 0.019
Identities = 20/70 (28%), Positives = 36/70 (51%), Gaps = 4/70 (5%)
Query: 288 RKDVGPMYSYVALYKFLPQENNDLALQPGDRIMLVDDSN---EDWWKGKIGDRVGFFPAN 344
R+ + +Y ALY F + +++++ GD I+ VD+ W G G+FP N
Sbjct: 753 RETASVLVNYRALYPFEARNHDEMSFNSGD-IIQVDEKTVGEPGWLYGSFQGNFGWFPCN 811
Query: 345 FVQRVRPGEN 354
+V+++ EN
Sbjct: 812 YVEKMPSSEN 821
Score = 33.9 bits (76), Expect = 0.28
Identities = 15/54 (27%), Positives = 30/54 (55%), Gaps = 5/54 (9%)
Query: 303 FLPQENNDLALQPGDRIMLVDDSNEDWWKGKIGDR-----VGFFPANFVQRVRP 351
++ + L+L PG I+++ + WW+G++ R G+FPA+ V+ + P
Sbjct: 1064 YVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGP 1117
Score = 33.5 bits (75), Expect = 0.36
Identities = 19/59 (32%), Positives = 33/59 (55%), Gaps = 2/59 (3%)
Query: 299 ALYKFLPQENNDLALQPGDRIMLVDDSNEDWWKGKIGDRVGFFPANFVQRVRPGENVWR 357
AL + +++N L D I+ V + E+WW G++ G+FP ++V ++ PG V R
Sbjct: 905 ALCSWTAKKDNHLNFSKHD-IITVLEQQENWWFGEVHGGRGWFPKSYV-KIIPGSEVKR 961
>gi|4507249 signal transducing adaptor molecule 1 [Homo sapiens]
Length = 540
Score = 53.1 bits (126), Expect = 4e-07
Identities = 21/48 (43%), Positives = 33/48 (68%)
Query: 299 ALYKFLPQENNDLALQPGDRIMLVDDSNEDWWKGKIGDRVGFFPANFV 346
A+Y F E+N+L + G+ I ++DDS+ +WWKG+ +G FP+NFV
Sbjct: 217 AIYDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETHQGIGLFPSNFV 264
>gi|20357552 cortactin isoform a [Homo sapiens]
Length = 550
Score = 52.8 bits (125), Expect = 6e-07
Identities = 46/167 (27%), Positives = 71/167 (42%), Gaps = 19/167 (11%)
Query: 181 EPPPVCATSKESPPTGDSGKVDPVYETLRYGTSLALMNRSSFSSTSESPTRSLSERDELT 240
+ PPV S PT + PVYE L R S T P S+ D
Sbjct: 400 QTPPV---SPAPQPTEERLPSSPVYEDAA-SFKAELSYRGPVSGTEPEPVYSMEAADYRE 455
Query: 241 EDGEGSIRSSEEGPGDSASPVFTAPAESEGPGPEEKSPGQQLPKATLRKDVGPMYSYVAL 300
SS++G + V+ + AE+ G P E S + D+G + VAL
Sbjct: 456 A-------SSQQGLAYATEAVYES-AEAPGHYPAEDSTYDEY-----ENDLG--ITAVAL 500
Query: 301 YKFLPQENNDLALQPGDRIMLVDDSNEDWWKGKIGDRVGFFPANFVQ 347
Y + +++++ P D I ++ ++ WW+G R G FPAN+V+
Sbjct: 501 YDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGLFPANYVE 547
>gi|20357556 cortactin isoform b [Homo sapiens]
Length = 513
Score = 52.8 bits (125), Expect = 6e-07
Identities = 46/167 (27%), Positives = 71/167 (42%), Gaps = 19/167 (11%)
Query: 181 EPPPVCATSKESPPTGDSGKVDPVYETLRYGTSLALMNRSSFSSTSESPTRSLSERDELT 240
+ PPV S PT + PVYE L R S T P S+ D
Sbjct: 363 QTPPV---SPAPQPTEERLPSSPVYEDAA-SFKAELSYRGPVSGTEPEPVYSMEAADYRE 418
Query: 241 EDGEGSIRSSEEGPGDSASPVFTAPAESEGPGPEEKSPGQQLPKATLRKDVGPMYSYVAL 300
SS++G + V+ + AE+ G P E S + D+G + VAL
Sbjct: 419 A-------SSQQGLAYATEAVYES-AEAPGHYPAEDSTYDEY-----ENDLG--ITAVAL 463
Query: 301 YKFLPQENNDLALQPGDRIMLVDDSNEDWWKGKIGDRVGFFPANFVQ 347
Y + +++++ P D I ++ ++ WW+G R G FPAN+V+
Sbjct: 464 YDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGLFPANYVE 510
>gi|188219625 signal transducing adaptor molecule 2 [Homo sapiens]
Length = 525
Score = 52.4 bits (124), Expect = 7e-07
Identities = 22/48 (45%), Positives = 34/48 (70%)
Query: 299 ALYKFLPQENNDLALQPGDRIMLVDDSNEDWWKGKIGDRVGFFPANFV 346
ALY F E+N+L + G+ I+++DDS+ +WWKG+ +G FP+NFV
Sbjct: 209 ALYDFEAVEDNELTFKHGEIIIVLDDSDANWWKGENHRGIGLFPSNFV 256
>gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens]
Length = 516
Score = 52.4 bits (124), Expect = 7e-07
Identities = 22/49 (44%), Positives = 34/49 (69%)
Query: 299 ALYKFLPQENNDLALQPGDRIMLVDDSNEDWWKGKIGDRVGFFPANFVQ 347
A++ + N +LA + GD I ++D SN+DWW G+I D G+FPA+FV+
Sbjct: 15 AVWDHVTMANRELAFKAGDVIKVLDASNKDWWWGQIDDEEGWFPASFVR 63
>gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Homo
sapiens]
Length = 217
Score = 51.2 bits (121), Expect = 2e-06
Identities = 22/51 (43%), Positives = 33/51 (64%)
Query: 299 ALYKFLPQENNDLALQPGDRIMLVDDSNEDWWKGKIGDRVGFFPANFVQRV 349
AL+ F PQE+ +L + GD I ++D+S+ +WWKG + G FP N+V V
Sbjct: 163 ALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPV 213
Score = 35.0 bits (79), Expect = 0.12
Identities = 13/51 (25%), Positives = 33/51 (64%), Gaps = 1/51 (1%)
Query: 298 VALYKFLPQENNDLALQPGDRI-MLVDDSNEDWWKGKIGDRVGFFPANFVQ 347
+A Y F +++L+ + GD + +L ++ +++W+K ++ + GF P N+++
Sbjct: 4 IAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIE 54
>gi|45359859 growth factor receptor-bound protein 2 isoform 2 [Homo
sapiens]
Length = 176
Score = 51.2 bits (121), Expect = 2e-06
Identities = 22/51 (43%), Positives = 33/51 (64%)
Query: 299 ALYKFLPQENNDLALQPGDRIMLVDDSNEDWWKGKIGDRVGFFPANFVQRV 349
AL+ F PQE+ +L + GD I ++D+S+ +WWKG + G FP N+V V
Sbjct: 122 ALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPV 172
Score = 35.0 bits (79), Expect = 0.12
Identities = 13/51 (25%), Positives = 33/51 (64%), Gaps = 1/51 (1%)
Query: 298 VALYKFLPQENNDLALQPGDRI-MLVDDSNEDWWKGKIGDRVGFFPANFVQ 347
+A Y F +++L+ + GD + +L ++ +++W+K ++ + GF P N+++
Sbjct: 4 IAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIE 54
>gi|115529463 protein kinase D1 [Homo sapiens]
Length = 912
Score = 50.8 bits (120), Expect = 2e-06
Identities = 44/194 (22%), Positives = 85/194 (43%), Gaps = 15/194 (7%)
Query: 44 LRSKSLENFFLRSGSELKCPTEVLLTPPTPLPPPSPPPTASDRGLATPSPSPCPVPRPL- 102
+R + L N L S ++ + L T P P+ S G S S + RP+
Sbjct: 199 VRRRRLSNVSLTGVSTIRTSSAELSTSAPDEPLLQKSPSESFIGREKRSNSQSYIGRPIH 258
Query: 103 ---AALKPVRL-HSFQEHVFKRASPCELCHQLIVGNSKQGLRCKMCKVSVHLWCSEEISH 158
+ V++ H+F H + R + C+ C +L+ G +QGL+CK C+ + H C+ ++ +
Sbjct: 259 LDKILMSKVKVPHTFVIHSYTRPTVCQYCKKLLKGLFRQGLQCKDCRFNCHKRCAPKVPN 318
Query: 159 QQCPGKTSTS---FRRNFSSPLLVHEPPPVCATSKESPPTGDSGKVDPVYETLRYGTSLA 215
C G+ + + S +++ E S ++ +SG +D + E + +A
Sbjct: 319 -NCLGEVTINGDLLSPGAESDVVMEE------GSDDNDSERNSGLMDDMEEAMVQDAEMA 371
Query: 216 LMNRSSFSSTSESP 229
+ + S + P
Sbjct: 372 MAECQNDSGEMQDP 385
Score = 37.4 bits (85), Expect = 0.025
Identities = 16/56 (28%), Positives = 33/56 (58%), Gaps = 1/56 (1%)
Query: 108 VRLHSFQEHVFKRASPCELCHQLIVGNSKQGLRCKMCKVSVHLWCSEEISHQQCPG 163
+R H+ H ++ + C+ C +++ G +QGL+C+ C ++ H C+ +I + C G
Sbjct: 144 IRPHALFVHSYRAPAFCDHCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPN-NCSG 198
>gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Homo
sapiens]
Length = 847
Score = 50.8 bits (120), Expect = 2e-06
Identities = 21/57 (36%), Positives = 36/57 (63%), Gaps = 5/57 (8%)
Query: 297 YVALYKFLPQENNDLALQPGDRIMLVD-----DSNEDWWKGKIGDRVGFFPANFVQR 348
+ AL+ + P ++LAL+ GDR+ ++ +E WW G++G +VG FP+N+V R
Sbjct: 46 WTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSR 102
Score = 30.8 bits (68), Expect = 2.3
Identities = 28/99 (28%), Positives = 36/99 (36%), Gaps = 9/99 (9%)
Query: 6 EKENEPDDAATHSPPGTVSALQETKLQRFKRSLSLKTILRSKSLENFFLRSGSELKCPTE 65
E+ P A S GT +Q L+ +L S L G + E
Sbjct: 621 EEPKRPVPAERGSSSGTPKLIQRALLRG-------TALLASLGLGRDLQPPGGPGRERGE 673
Query: 66 VLLTPPTPLPPPSP--PPTASDRGLATPSPSPCPVPRPL 102
TPPTP P P P PP + + +P P P PL
Sbjct: 674 SPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPL 712
>gi|120587025 SH3 and multiple ankyrin repeat domains 1 [Homo
sapiens]
Length = 2161
Score = 50.8 bits (120), Expect = 2e-06
Identities = 37/172 (21%), Positives = 72/172 (41%), Gaps = 9/172 (5%)
Query: 178 LVHEPPPVCATSKESPPTGDSGKVDPVYETLRYGTSLALMNRSSFSSTSESPTRSLSERD 237
+V P ++ P +G G+ P T + + S + + SP+R D
Sbjct: 449 MVFSAPGAASSGAPGPTSGSQGQSQPSAPTTKLSSGTLRSASSPRGARARSPSRGRHPED 508
Query: 238 ELTEDGEGSIRSSEEGPGDSASPVFTAPAESEGPGPEEKSPGQQLPKATLRKDVGPMYSY 297
+ R P S +P + G G S G + + L V P S+
Sbjct: 509 --------AKRQPRGRPSSSGTPREGPAGGTGGSGGPGGSLGSRGRRRKLYSAV-PGRSF 559
Query: 298 VALYKFLPQENNDLALQPGDRIMLVDDSNEDWWKGKIGDRVGFFPANFVQRV 349
+A+ + Q +++L G++I ++ +W+G++ RVG+FP++ ++ V
Sbjct: 560 MAVKSYQAQAEGEISLSKGEKIKVLSIGEGGFWEGQVKGRVGWFPSDCLEEV 611
Score = 31.2 bits (69), Expect = 1.8
Identities = 32/112 (28%), Positives = 43/112 (38%), Gaps = 29/112 (25%)
Query: 11 PDDAATHSPPGTVSALQETKLQRFKRSLSLKTIL----RSKSLENFFLRSGSELKCPTEV 66
P A+ PP V+A E K S+ + TI+ + S S +E + PT+
Sbjct: 1132 PTSPASPQPPPAVAAPSE------KNSIPIPTIIIKAPSTSSSGRSSQGSSTEAEPPTQP 1185
Query: 67 LLT--------PPTPLPPPSPPPTASDRGLATPSPSPCPVPRPLAALKPVRL 110
T P+P P SP P PSP PVP P + P L
Sbjct: 1186 EPTGGGGGGGSSPSPAPAMSPVP-----------PSPSPVPTPASPSGPATL 1226
Score = 30.4 bits (67), Expect = 3.0
Identities = 17/37 (45%), Positives = 19/37 (51%), Gaps = 3/37 (8%)
Query: 64 TEVLLTPPT---PLPPPSPPPTASDRGLATPSPSPCP 97
+E + PPT P PP S PP S G TPSP P
Sbjct: 917 SEDIPPPPTTSPPEPPYSTPPVPSSSGRLTPSPRGGP 953
Score = 30.4 bits (67), Expect = 3.0
Identities = 18/43 (41%), Positives = 19/43 (44%), Gaps = 3/43 (6%)
Query: 70 PPTPLPPPSPPPTASDRGLATPSPSPCPVPRPLAALKPVRLHS 112
P +PL P P P ATP P PVP P A P L S
Sbjct: 1580 PESPLTPGPPHPLPDTPAPATPLP---PVPPPAVAAAPPTLDS 1619
Score = 29.3 bits (64), Expect = 6.8
Identities = 15/34 (44%), Positives = 16/34 (47%)
Query: 70 PPTPLPPPSPPPTASDRGLATPSPSPCPVPRPLA 103
PP PLP S P P P P P+P PLA
Sbjct: 1823 PPVPLPTASSLPRKLLPWEEGPGPPPPPLPGPLA 1856
>gi|67514036 SH3-domain kinase binding protein 1 isoform b [Homo
sapiens]
Length = 628
Score = 50.1 bits (118), Expect = 4e-06
Identities = 18/49 (36%), Positives = 33/49 (67%)
Query: 301 YKFLPQENNDLALQPGDRIMLVDDSNEDWWKGKIGDRVGFFPANFVQRV 349
+ +LPQ +++L L+ GD I +V + E WW+G + + G FP+NF++ +
Sbjct: 70 FSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKEL 118
Score = 45.4 bits (106), Expect = 9e-05
Identities = 38/156 (24%), Positives = 62/156 (39%), Gaps = 37/156 (23%)
Query: 232 SLSERDELTEDGEGSIRSSEEGPGDSASPVFTAPAESEGPG------------------- 272
SL E DG S + EG + + P + +G G
Sbjct: 137 SLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEV 196
Query: 273 -----PEEKSPGQQLPKATLRKDVGPM----------YSYVALYKFLPQENNDLALQPGD 317
P EK+ G++LP T D Y V ++ + Q +++L ++ GD
Sbjct: 197 ENDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKV-IFPYEAQNDDELTIKEGD 255
Query: 318 RIMLVDDSNED--WWKGKIGDRVGFFPANFVQRVRP 351
+ L++ D WW+G++ R G FP NFV+ + P
Sbjct: 256 IVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPP 291
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.132 0.398
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,563,604
Number of Sequences: 37866
Number of extensions: 1259031
Number of successful extensions: 17914
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 500
Number of HSP's successfully gapped in prelim test: 475
Number of HSP's that attempted gapping in prelim test: 10452
Number of HSP's gapped (non-prelim): 5687
length of query: 411
length of database: 18,247,518
effective HSP length: 105
effective length of query: 306
effective length of database: 14,271,588
effective search space: 4367105928
effective search space used: 4367105928
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.