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Search of human proteins with 38683827
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|38683827 ADAM metallopeptidase with thrombospondin type 1
motif, 7 preproprotein [Homo sapiens]
(1686 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|38683827 ADAM metallopeptidase with thrombospondin type 1 mot... 3642 0.0
gi|51558724 ADAM metallopeptidase with thrombospondin type 1 mot... 1188 0.0
gi|64276808 ADAM metallopeptidase with thrombospondin type 1 mot... 748 0.0
gi|56121815 ADAM metallopeptidase with thrombospondin type 1 mot... 681 0.0
gi|40806187 ADAM metallopeptidase with thrombospondin type 1 mot... 645 0.0
gi|110735441 ADAM metallopeptidase with thrombospondin type 1 mo... 639 0.0
gi|112789555 ADAM metallopeptidase with thrombospondin type 1 mo... 584 e-166
gi|110611170 ADAM metallopeptidase with thrombospondin type 1 mo... 579 e-165
gi|33624896 ADAM metallopeptidase with thrombospondin type 1 mot... 554 e-157
gi|124430557 a disintegrin-like and metalloprotease with thrombo... 532 e-150
gi|110611167 ADAM metallopeptidase with thrombospondin type 1 mo... 508 e-143
gi|21265052 ADAM metallopeptidase with thrombospondin type 1 mot... 506 e-143
gi|110825974 ADAM metallopeptidase with thrombospondin type 1 mo... 499 e-141
gi|21265037 ADAM metallopeptidase with thrombospondin type 1 mot... 497 e-140
gi|21265058 a disintegrin-like and metalloprotease (reprolysin t... 488 e-137
gi|50845384 ADAM metallopeptidase with thrombospondin type 1 mot... 480 e-135
gi|153792351 ADAM metallopeptidase with thrombospondin type 1 mo... 452 e-127
gi|195539372 ADAM metallopeptidase with thrombospondin type 1 mo... 396 e-110
gi|157427675 ADAM metallopeptidase with thrombospondin type 1 mo... 376 e-103
gi|239756385 PREDICTED: similar to hCG1991431 [Homo sapiens] 370 e-102
gi|73695936 ADAM metallopeptidase with thrombospondin type 1 mot... 355 2e-97
gi|21265034 ADAM metallopeptidase with thrombospondin type 1 mot... 355 2e-97
gi|21265043 ADAM metallopeptidase with thrombospondin type 1 mot... 330 7e-90
gi|145309328 papilin [Homo sapiens] 308 4e-83
gi|38016904 thrombospondin repeat containing 1 isoform 1 [Homo s... 263 1e-69
gi|56788359 thrombospondin repeat containing 1 isoform 2 [Homo s... 263 1e-69
gi|11038659 ADAM metallopeptidase with thrombospondin type 1 mot... 239 2e-62
gi|94536854 thrombospondin, type I, domain containing 4 [Homo sa... 232 2e-60
gi|145275198 ADAMTS-like 3 precursor [Homo sapiens] 231 3e-60
gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens] 230 8e-60
>gi|38683827 ADAM metallopeptidase with thrombospondin type 1 motif, 7
preproprotein [Homo sapiens]
Length = 1686
Score = 3642 bits (9443), Expect = 0.0
Identities = 1686/1686 (100%), Positives = 1686/1686 (100%)
Query: 1 MPGGPSPRSPAPLLRPLLLLLCALAPGAPGPAPGRATEGRAALDIVHPVRVDAGGSFLSY 60
MPGGPSPRSPAPLLRPLLLLLCALAPGAPGPAPGRATEGRAALDIVHPVRVDAGGSFLSY
Sbjct: 1 MPGGPSPRSPAPLLRPLLLLLCALAPGAPGPAPGRATEGRAALDIVHPVRVDAGGSFLSY 60
Query: 61 ELWPRALRKRDVSVRRDAPAFYELQYRGRELRFNLTANQHLLAPGFVSETRRRGGLGRAH 120
ELWPRALRKRDVSVRRDAPAFYELQYRGRELRFNLTANQHLLAPGFVSETRRRGGLGRAH
Sbjct: 61 ELWPRALRKRDVSVRRDAPAFYELQYRGRELRFNLTANQHLLAPGFVSETRRRGGLGRAH 120
Query: 121 IRAHTPACHLLGEVQDPELEGGLAAISACDGLKGVFQLSNEDYFIEPLDSAPARPGHAQP 180
IRAHTPACHLLGEVQDPELEGGLAAISACDGLKGVFQLSNEDYFIEPLDSAPARPGHAQP
Sbjct: 121 IRAHTPACHLLGEVQDPELEGGLAAISACDGLKGVFQLSNEDYFIEPLDSAPARPGHAQP 180
Query: 181 HVVYKRQAPERLAQRGDSSAPSTCGVQVYPELESRRERWEQRQQWRRPRLRRLHQRSVSK 240
HVVYKRQAPERLAQRGDSSAPSTCGVQVYPELESRRERWEQRQQWRRPRLRRLHQRSVSK
Sbjct: 181 HVVYKRQAPERLAQRGDSSAPSTCGVQVYPELESRRERWEQRQQWRRPRLRRLHQRSVSK 240
Query: 241 EKWVETLVVADAKMVEYHGQPQVESYVLTIMNMVAGLFHDPSIGNPIHITIVRLVLLEDE 300
EKWVETLVVADAKMVEYHGQPQVESYVLTIMNMVAGLFHDPSIGNPIHITIVRLVLLEDE
Sbjct: 241 EKWVETLVVADAKMVEYHGQPQVESYVLTIMNMVAGLFHDPSIGNPIHITIVRLVLLEDE 300
Query: 301 EEDLKITHHADNTLKSFCKWQKSINMKGDAHPLHHDTAILLTRKDLCAAMNRPCETLGLS 360
EEDLKITHHADNTLKSFCKWQKSINMKGDAHPLHHDTAILLTRKDLCAAMNRPCETLGLS
Sbjct: 301 EEDLKITHHADNTLKSFCKWQKSINMKGDAHPLHHDTAILLTRKDLCAAMNRPCETLGLS 360
Query: 361 HVAGMCQPHRSCSINEDTGLPLAFTVAHELGHSFGIQHDGSGNDCEPVGKRPFIMSPQLL 420
HVAGMCQPHRSCSINEDTGLPLAFTVAHELGHSFGIQHDGSGNDCEPVGKRPFIMSPQLL
Sbjct: 361 HVAGMCQPHRSCSINEDTGLPLAFTVAHELGHSFGIQHDGSGNDCEPVGKRPFIMSPQLL 420
Query: 421 YDAAPLTWSRCSRQYITRFLDRGWGLCLDDPPAKDIIDFPSVPPGVLYDVSHQCRLQYGA 480
YDAAPLTWSRCSRQYITRFLDRGWGLCLDDPPAKDIIDFPSVPPGVLYDVSHQCRLQYGA
Sbjct: 421 YDAAPLTWSRCSRQYITRFLDRGWGLCLDDPPAKDIIDFPSVPPGVLYDVSHQCRLQYGA 480
Query: 481 YSAFCEDMDNVCHTLWCSVGTTCHSKLDAAVDGTRCGENKWCLSGECVPVGFRPEAVDGG 540
YSAFCEDMDNVCHTLWCSVGTTCHSKLDAAVDGTRCGENKWCLSGECVPVGFRPEAVDGG
Sbjct: 481 YSAFCEDMDNVCHTLWCSVGTTCHSKLDAAVDGTRCGENKWCLSGECVPVGFRPEAVDGG 540
Query: 541 WSGWSAWSICSRSCGMGVQSAERQCTQPTPKYKGRYCVGERKRFRLCNLQACPAGRPSFR 600
WSGWSAWSICSRSCGMGVQSAERQCTQPTPKYKGRYCVGERKRFRLCNLQACPAGRPSFR
Sbjct: 541 WSGWSAWSICSRSCGMGVQSAERQCTQPTPKYKGRYCVGERKRFRLCNLQACPAGRPSFR 600
Query: 601 HVQCSHFDAMLYKGQLHTWVPVVNDVNPCELHCRPANEYFAEKLRDAVVDGTPCYQVRAS 660
HVQCSHFDAMLYKGQLHTWVPVVNDVNPCELHCRPANEYFAEKLRDAVVDGTPCYQVRAS
Sbjct: 601 HVQCSHFDAMLYKGQLHTWVPVVNDVNPCELHCRPANEYFAEKLRDAVVDGTPCYQVRAS 660
Query: 661 RDLCINGICKNVGCDFEIDSGAMEDRCGVCHGNGSTCHTVSGTFEEAEGLGYVDVGLIPA 720
RDLCINGICKNVGCDFEIDSGAMEDRCGVCHGNGSTCHTVSGTFEEAEGLGYVDVGLIPA
Sbjct: 661 RDLCINGICKNVGCDFEIDSGAMEDRCGVCHGNGSTCHTVSGTFEEAEGLGYVDVGLIPA 720
Query: 721 GAREIRIQEVAEAANFLALRSEDPEKYFLNGGWTIQWNGDYQVAGTTFTYARRGNWENLT 780
GAREIRIQEVAEAANFLALRSEDPEKYFLNGGWTIQWNGDYQVAGTTFTYARRGNWENLT
Sbjct: 721 GAREIRIQEVAEAANFLALRSEDPEKYFLNGGWTIQWNGDYQVAGTTFTYARRGNWENLT 780
Query: 781 SPGPTKEPVWIQLLFQESNPGVHYEYTIHREAGGHDEVPPPVFSWHYGPWTKCTVTCGRG 840
SPGPTKEPVWIQLLFQESNPGVHYEYTIHREAGGHDEVPPPVFSWHYGPWTKCTVTCGRG
Sbjct: 781 SPGPTKEPVWIQLLFQESNPGVHYEYTIHREAGGHDEVPPPVFSWHYGPWTKCTVTCGRG 840
Query: 841 VQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQPCPARWWAGEWQLCSSSCGPGGL 900
VQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQPCPARWWAGEWQLCSSSCGPGGL
Sbjct: 841 VQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQPCPARWWAGEWQLCSSSCGPGGL 900
Query: 901 SRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPCNRHVPCPATWAVGNWSQCSVTCGE 960
SRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPCNRHVPCPATWAVGNWSQCSVTCGE
Sbjct: 901 SRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPCNRHVPCPATWAVGNWSQCSVTCGE 960
Query: 961 GTQRRNVLCTNDTGVPCDEAQQPASEVTCSLPLCRWPLGTLGPEGSGSGSSSHELFNEAD 1020
GTQRRNVLCTNDTGVPCDEAQQPASEVTCSLPLCRWPLGTLGPEGSGSGSSSHELFNEAD
Sbjct: 961 GTQRRNVLCTNDTGVPCDEAQQPASEVTCSLPLCRWPLGTLGPEGSGSGSSSHELFNEAD 1020
Query: 1021 FIPHHLAPRPSPASSPKPGTMGNAIEEEAPELDLPGPVFVDDFYYDYNFINFHEDLSYGP 1080
FIPHHLAPRPSPASSPKPGTMGNAIEEEAPELDLPGPVFVDDFYYDYNFINFHEDLSYGP
Sbjct: 1021 FIPHHLAPRPSPASSPKPGTMGNAIEEEAPELDLPGPVFVDDFYYDYNFINFHEDLSYGP 1080
Query: 1081 SEEPDLDLAGTGDRTPPPHSHPAAPSTGSPVPATEPPAAKEEGVLGPWSPSPWPSQAGRS 1140
SEEPDLDLAGTGDRTPPPHSHPAAPSTGSPVPATEPPAAKEEGVLGPWSPSPWPSQAGRS
Sbjct: 1081 SEEPDLDLAGTGDRTPPPHSHPAAPSTGSPVPATEPPAAKEEGVLGPWSPSPWPSQAGRS 1140
Query: 1141 PPPPSEQTPGNPLINFLPEEDTPIGAPDLGLPSLSWPRVSTDGLQTPATPESQNDFPVGK 1200
PPPPSEQTPGNPLINFLPEEDTPIGAPDLGLPSLSWPRVSTDGLQTPATPESQNDFPVGK
Sbjct: 1141 PPPPSEQTPGNPLINFLPEEDTPIGAPDLGLPSLSWPRVSTDGLQTPATPESQNDFPVGK 1200
Query: 1201 DSQSQLPPPWRDRTNEVFKDDEEPKGRGAPHLPPRPSSTLPPLSPVGSTHSSPSPDVAEL 1260
DSQSQLPPPWRDRTNEVFKDDEEPKGRGAPHLPPRPSSTLPPLSPVGSTHSSPSPDVAEL
Sbjct: 1201 DSQSQLPPPWRDRTNEVFKDDEEPKGRGAPHLPPRPSSTLPPLSPVGSTHSSPSPDVAEL 1260
Query: 1261 WTGGTVAWEPALEGGLGPVDSELWPTVGVASLLPPPIAPLPEMKVRDSSLEPGTPSFPTP 1320
WTGGTVAWEPALEGGLGPVDSELWPTVGVASLLPPPIAPLPEMKVRDSSLEPGTPSFPTP
Sbjct: 1261 WTGGTVAWEPALEGGLGPVDSELWPTVGVASLLPPPIAPLPEMKVRDSSLEPGTPSFPTP 1320
Query: 1321 GPGSWDLQTVAVWGTFLPTTLTGLGHMPEPALNPGPKGQPESLSPEVPLSSRLLSTPAWD 1380
GPGSWDLQTVAVWGTFLPTTLTGLGHMPEPALNPGPKGQPESLSPEVPLSSRLLSTPAWD
Sbjct: 1321 GPGSWDLQTVAVWGTFLPTTLTGLGHMPEPALNPGPKGQPESLSPEVPLSSRLLSTPAWD 1380
Query: 1381 SPANSHRVPETQPLAPSLAEAGPPADPLVVRNAGWQAGNWSECSTTCGLGAVWRPVRCSS 1440
SPANSHRVPETQPLAPSLAEAGPPADPLVVRNAGWQAGNWSECSTTCGLGAVWRPVRCSS
Sbjct: 1381 SPANSHRVPETQPLAPSLAEAGPPADPLVVRNAGWQAGNWSECSTTCGLGAVWRPVRCSS 1440
Query: 1441 GRDEDCAPAGRPQPARRCHLRPCATWHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRP 1500
GRDEDCAPAGRPQPARRCHLRPCATWHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRP
Sbjct: 1441 GRDEDCAPAGRPQPARRCHLRPCATWHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRP 1500
Query: 1501 FHCQPGPAKPPAHRPCGAQPCLSWYTSSWRECSEACGGGEQQRLVTCPEPGLCEEALRPN 1560
FHCQPGPAKPPAHRPCGAQPCLSWYTSSWRECSEACGGGEQQRLVTCPEPGLCEEALRPN
Sbjct: 1501 FHCQPGPAKPPAHRPCGAQPCLSWYTSSWRECSEACGGGEQQRLVTCPEPGLCEEALRPN 1560
Query: 1561 TTRPCNTHPCTQWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESS 1620
TTRPCNTHPCTQWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESS
Sbjct: 1561 TTRPCNTHPCTQWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESS 1620
Query: 1621 RPCGTEDCEPVEPPRCERDRLSFGFCETLRLLGRCQLPTIRTQCCRSCSPPSHGAPSRGH 1680
RPCGTEDCEPVEPPRCERDRLSFGFCETLRLLGRCQLPTIRTQCCRSCSPPSHGAPSRGH
Sbjct: 1621 RPCGTEDCEPVEPPRCERDRLSFGFCETLRLLGRCQLPTIRTQCCRSCSPPSHGAPSRGH 1680
Query: 1681 QRVARR 1686
QRVARR
Sbjct: 1681 QRVARR 1686
>gi|51558724 ADAM metallopeptidase with thrombospondin type 1 motif,
12 preproprotein [Homo sapiens]
Length = 1594
Score = 1188 bits (3073), Expect = 0.0
Identities = 610/1239 (49%), Positives = 788/1239 (63%), Gaps = 98/1239 (7%)
Query: 21 LCALAPGAPGPA--PGRATE----GRAALDIVHPVRVDAGGSFLSYEL-WP--RALRKRD 71
LC PGP P R E G +V PVRVDA G FLSY L +P + RKRD
Sbjct: 24 LCYGRQPQPGPVRFPDRRQEHFIKGLPEYHVVGPVRVDASGHFLSYGLHYPITSSRRKRD 83
Query: 72 VSVRRDAPAFYELQYRGRELRFNLTANQHLLAPGFVSETRRRGGLGRAHIRAHT-PACHL 130
+ D +Y + + ++L FNLT NQ L+ ++ E +R G L + A + P CHL
Sbjct: 84 LDGSEDW-VYYRISHEEKDLFFNLTVNQGFLSNSYIME-KRYGNLSHVKMMASSAPLCHL 141
Query: 131 LGEVQDPELEGGLAAISACDGLKGVFQLSNEDYFIEPLDSAPARPGHAQPHVVYKRQ-AP 189
G V G AA+SAC GL G FQL + D+FIEP+ P G PH+VY+RQ P
Sbjct: 142 SGTVLQQGTRVGTAALSACHGLTGFFQLPHGDFFIEPVKKHPLVEGGYHPHIVYRRQKVP 201
Query: 190 ERLAQRGDSSAPSTCGVQVYPELESRRERWEQRQQWRRPRL--RRLHQRSVSKEKWVETL 247
E + TCG++ + ++E W R++W R L R L +RS+SKE+WVETL
Sbjct: 202 E--------TKEPTCGLKDSVNISQKQELW--REKWERHNLPSRSLSRRSISKERWVETL 251
Query: 248 VVADAKMVEYHGQPQVESYVLTIMNMVAGLFHDPSIGNPIHITIVRLVLLEDEEEDLKIT 307
VVAD KM+EYHG VESY+LTIMNMV GLFH+PSIGN IHI +VRL+LLE+EE+ LKI
Sbjct: 252 VVADTKMIEYHGSENVESYILTIMNMVTGLFHNPSIGNAIHIVVVRLILLEEEEQGLKIV 311
Query: 308 HHADNTLKSFCKWQKSINMKGDAHPLHHDTAILLTRKDLCAAMNRPCETLGLSHVAGMCQ 367
HHA+ TL SFCKWQKSIN K D +P+HHD A+LLTRKD+CA NRPCETLGLSH++GMCQ
Sbjct: 312 HHAEKTLSSFCKWQKSINPKSDLNPVHHDVAVLLTRKDICAGFNRPCETLGLSHLSGMCQ 371
Query: 368 PHRSCSINEDTGLPLAFTVAHELGHSFGIQHDGSGNDCEPVGKRPFIMSPQLLYDAAPLT 427
PHRSC+INED+GLPLAFT+AHELGHSFGIQHDG NDCEPVG+ P+IMS QL YD PLT
Sbjct: 372 PHRSCNINEDSGLPLAFTIAHELGHSFGIQHDGKENDCEPVGRHPYIMSRQLQYDPTPLT 431
Query: 428 WSRCSRQYITRFLDRGWGLCLDDPPAKDIIDFPSVPPGVLYDVSHQCRLQYGAYSAFCED 487
WS+CS +YITRFLDRGWG CLDD P K + + PGV+YDV HQC+LQYG + FC++
Sbjct: 432 WSKCSEEYITRFLDRGWGFCLDDIPKKKGLKSKVIAPGVIYDVHHQCQLQYGPNATFCQE 491
Query: 488 MDNVCHTLWCSVGTTCHSKLDAAVDGTRCGENKWCLSGECVPVGFRPEAVDGGWSGWSAW 547
++NVC TLWCSV C SKLDAA DGT+CGE KWC++G+C+ VG +PE++ GGW WS W
Sbjct: 492 VENVCQTLWCSVKGFCRSKLDAAADGTQCGEKKWCMAGKCITVGKKPESIPGGWGRWSPW 551
Query: 548 SICSRSCGMGVQSAERQCTQPTPKYKGRYCVGERKRFRLCNLQACPAGRPSFRHVQCSHF 607
S CSR+CG GVQSAER C P PK+ G+YC GERKR+RLCN+ C + P+FR +QCS F
Sbjct: 552 SHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRLCNVHPCRSEAPTFRQMQCSEF 611
Query: 608 DAMLYKGQLHTWVPVVNDVNPCELHCRPANEYFAEKLRDAVVDGTPCYQVRASRDLCING 667
D + YK +L+ W P+ N +PCEL+CRP + F+EK+ DAV+DGTPC++ SR++CING
Sbjct: 612 DTVPYKNELYHWFPIFNPAHPCELYCRPIDGQFSEKMLDAVIDGTPCFEGGNSRNVCING 671
Query: 668 ICKNVGCDFEIDSGAMEDRCGVCHGNGSTCHTVSGTFEEAEGLGYVDVGLIPAGAREIRI 727
ICK VGCD+EIDS A EDRCGVC G+GS+C TV F++ EG GYVD+GLIP GAR+IR+
Sbjct: 672 ICKMVGCDYEIDSNATEDRCGVCLGDGSSCQTVRKMFKQKEGSGYVDIGLIPKGARDIRV 731
Query: 728 QEVAEAANFLALRSEDPEKYFLNGGWTIQWNGDYQVAGTTFTYARRGNWENLTSPGPTKE 787
E+ A NFLA+RSEDPEKY+LNGG+ IQWNG+Y++AGT F Y R+G+ E L + GPT E
Sbjct: 732 MEIEGAGNFLAIRSEDPEKYYLNGGFIIQWNGNYKLAGTVFQYDRKGDLEKLMATGPTNE 791
Query: 788 PVWIQLLFQESNPGVHYEYTIHREAGGHDEVPPPVFSWHYGPWTKCTVTCGRGVQRQNVY 847
VWIQLLFQ +NPG+ YEYTI ++ G ++V ++ W YG WT+C+VTCG G++RQ +
Sbjct: 792 SVWIQLLFQVTNPGIKYEYTIQKD-GLDNDVEQQMYFWQYGHWTECSVTCGTGIRRQTAH 850
Query: 848 CLERQAGPVDEEHCDPLGRPDDQQRKCSEQPCPARWWAGEWQLCSSSCGPGGLSRRAVLC 907
C+++ G V CDP +P+ +Q+KC E+ CP RWWAGEW+ CS++CGP G +R VLC
Sbjct: 851 CIKKGRGMVKATFCDPETQPNGRQKKCHEKACPPRWWAGEWEACSATCGPHGEKKRTVLC 910
Query: 908 IRSVGLDEQSALEPPACEHLPRPPTETPCNRHVPCPATWAVGNWSQCSVTCGEGTQRRNV 967
I+++ DEQ AL P C+HL +P T CNR + CP+ W VGNWS+CSV+CG G + R+V
Sbjct: 911 IQTMVSDEQ-ALPPTDCQHLLKPKTLLSCNRDILCPSDWTVGNWSECSVSCGGGVRIRSV 969
Query: 968 LCTNDTGVPCDEAQQPASEVTCSLPLCRWPLGTLGP-EGSGSGSSSHELFNEADFIPHHL 1026
C + PCD ++P S C L C L P +G+ S + P L
Sbjct: 970 TCAKNHDEPCDVTRKPNSRALCGLQQCPSSRRVLKPNKGTISNGKN----------PPTL 1019
Query: 1027 APRPSPASSPK-------PGTMGN---AIEEEAP-----ELDLPGPVFVDDFYYDYNFIN 1071
P P P S P+ P +M AI +P E DL G + D ++
Sbjct: 1020 KPVPPPTSRPRMLTTPTGPESMSTSTPAISSPSPTTASKEGDLGGKQWQDSSTQPE--LS 1077
Query: 1072 FHEDLSYGPSEEPDLDLAGTGDRTPPPHSHPAAPSTGSPVPATE----PPAAKEEGVLGP 1127
+S G + +P L P + ++ TG P +E G+
Sbjct: 1078 SRYLISTGSTSQPILTSQSLS--IQPSEENVSSSDTG---PTSEGGLVATTTSGSGLSSS 1132
Query: 1128 WSPSPWP-----------------SQAGRSPPPPSEQTPGNPLI---NFLPEEDTPIGAP 1167
+P WP S +G P ++ NP+I +P D P+ +
Sbjct: 1133 RNPITWPVTPFYNTLTKGPEMEIHSGSGEEREQPEDKDESNPVIWTKIRVPGNDAPVEST 1192
Query: 1168 DLGL-----PSLS----WPRVST--DGL---QTPATPES 1192
++ L P LS WP ST +GL Q P T E+
Sbjct: 1193 EMPLAPPLTPDLSRESWWPPFSTVMEGLLPSQRPTTSET 1231
Score = 328 bits (842), Expect = 2e-89
Identities = 257/843 (30%), Positives = 348/843 (41%), Gaps = 147/843 (17%)
Query: 883 WWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPCNRHVPC 942
W G W CS +CG G + R+ CI+ + ++ C+ +P C
Sbjct: 828 WQYGHWTECSVTCGTG-IRRQTAHCIKK----GRGMVKATFCDPETQPNGRQKKCHEKAC 882
Query: 943 PATWAVGNWSQCSVTCG-EGTQRRNVLC-----TNDTGVP---CDEAQQPASEVTCSLP- 992
P W G W CS TCG G ++R VLC +++ +P C +P + ++C+
Sbjct: 883 PPRWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSCNRDI 942
Query: 993 LCR--WPLGTLGPEGSGSG----------SSSHELFNEADFIPHHLA-------PRPSPA 1033
LC W +G G + +H+ + P+ A P
Sbjct: 943 LCPSDWTVGNWSECSVSCGGGVRIRSVTCAKNHDEPCDVTRKPNSRALCGLQQCPSSRRV 1002
Query: 1034 SSPKPGTMGNAIEEEAPELDLPGPVFVDDFYYDYNFINFHEDLSYGPSEEPDLDLAGTGD 1093
P GT+ N + P L P P+ P + TG
Sbjct: 1003 LKPNKGTISNG--KNPPTLKPVPP----------------------PTSRPRMLTTPTG- 1037
Query: 1094 RTPPPHSHPAAPSTGSPVPATEPPAAKEEGVLG--PWSPSPW-PSQAGR---SPPPPSEQ 1147
P + P+ SP P T A +EG LG W S P + R S S+
Sbjct: 1038 ---PESMSTSTPAISSPSPTT----ASKEGDLGGKQWQDSSTQPELSSRYLISTGSTSQP 1090
Query: 1148 TPGNPLINFLPEEDTPIGAPDLGLPSLSWPRVSTDGLQTPATPESQNDFPVGKDSQSQLP 1207
+ ++ P E+ + + D G S GL T S S S+ P
Sbjct: 1091 ILTSQSLSIQPSEEN-VSSSDTG-------PTSEGGLVATTTSGSGL-------SSSRNP 1135
Query: 1208 PPWRDRTNEVFKDDEEPKGRGAPHLPPRPSSTLPPLSPVGSTHSSPSPDVAELWTGGTVA 1267
W P P + T P + S + V
Sbjct: 1136 ITW-------------------PVTPFYNTLTKGPEMEIHSGSGEEREQPEDKDESNPVI 1176
Query: 1268 WEPA-LEGGLGPVDSELWPTVGVASLLPPPIAPLPEMKVRDSSLEPGTPSFPTPGPGSWD 1326
W + G PV+S P L PP+ P D S E P F T G
Sbjct: 1177 WTKIRVPGNDAPVESTEMP-------LAPPLTP-------DLSRESWWPPFSTVMEGLLP 1222
Query: 1327 LQTVAVWGTFLPTTLTGLGHMPEPALNP-GPKGQPESLSPEVPLSSRLLSTPAWDSPANS 1385
Q T P + P L P G QPE S + + P N
Sbjct: 1223 SQRPTTSETGTPRVEGMVTEKPANTLLPLGGDHQPEP-------SGKTANRNHLKLPNNM 1275
Query: 1386 HRVPETQPL-----APSLAEAGPPADPLVVR-------NAGWQAGNWSECSTTCGLGAVW 1433
++ ++P+ A SL G + + +A W GNWSECSTTCGLGA W
Sbjct: 1276 NQTKSSEPVLTEEDATSLITEGFLLNASNYKQLTNGHGSAHWIVGNWSECSTTCGLGAYW 1335
Query: 1434 RPVRCSSGRDEDCAPAGRPQPARRCHLRPCATWHSGNWSKCSRSCGGGSSVRDVQCVDTR 1493
R V CS+ D DCA RP PA+RCHLRPCA W GNWSKCSR+C GG +R++QCVD+R
Sbjct: 1336 RRVECSTQMDSDCAAIQRPDPAKRCHLRPCAGWKVGNWSKCSRNCSGGFKIREIQCVDSR 1395
Query: 1494 DLRPLRPFHCQ-PGPAKPPAHRPCGAQPCLSWYTSSWRECSEACGGGEQQRLVTCPEPGL 1552
D R LRPFHCQ PP C +PC +W W +CS +CGGG Q+R V CP GL
Sbjct: 1396 DHRNLRPFHCQFLAGIPPPLSMSCNPEPCEAWQVEPWSQCSRSCGGGVQERGVFCP-GGL 1454
Query: 1553 CEEALRPNTTRPCNTHPCTQWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQ-- 1610
C+ RP +T CN H C W G W CS CGGG Q+R V+CV ++ G ED DQ
Sbjct: 1455 CDWTKRPTSTMSCNEHLCCHWATGNWDLCSTSCGGGFQKRTVQCVPSE-GNKTEDQDQCL 1513
Query: 1611 CGHEAWPESSRPCGTEDCEPVEPPRCERDRLSFGFCETLRLLGRCQLPTIRTQCCRSCSP 1670
C H+ P + C + C+ C +D+LS FC+TL+ + +C +PT+R +CC SC P
Sbjct: 1514 CDHKPRPPEFKKCNQQACKKSADLLCTKDKLSASFCQTLKAMKKCSVPTVRAECCFSC-P 1572
Query: 1671 PSH 1673
+H
Sbjct: 1573 QTH 1575
Score = 103 bits (258), Expect = 1e-21
Identities = 65/178 (36%), Positives = 85/178 (47%), Gaps = 19/178 (10%)
Query: 825 WHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQPCPARWW 884
W G W++C+ TCG G + V C + + C + RPD +R C +PC A W
Sbjct: 1317 WIVGNWSECSTTCGLGAYWRRVECSTQM-----DSDCAAIQRPDPAKR-CHLRPC-AGWK 1369
Query: 885 AGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLP--RPPTETPCNRHVPC 942
G W CS +C GG R + C+ S + L P C+ L PP CN PC
Sbjct: 1370 VGNWSKCSRNCS-GGFKIREIQCVDS---RDHRNLRPFHCQFLAGIPPPLSMSCNPE-PC 1424
Query: 943 PATWAVGNWSQCSVTCGEGTQRRNVLCTNDTGVPCDEAQQPASEVTCSLPL-CRWPLG 999
A W V WSQCS +CG G Q R V C G CD ++P S ++C+ L C W G
Sbjct: 1425 EA-WQVEPWSQCSRSCGGGVQERGVFC---PGGLCDWTKRPTSTMSCNEHLCCHWATG 1478
Score = 99.4 bits (246), Expect = 3e-20
Identities = 58/185 (31%), Positives = 78/185 (42%), Gaps = 26/185 (14%)
Query: 821 PVFSWHYGPWTKCTVTCGRGVQRQNVYCLE-RQAGPVDEEHCDPL-GRPDDQQRKCSEQP 878
P W G W+KC+ C G + + + C++ R + HC L G P C+ +P
Sbjct: 1364 PCAGWKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEP 1423
Query: 879 CPARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPCNR 938
C A W W CS SCG GG+ R V C + C+ RP + CN
Sbjct: 1424 CEA-WQVEPWSQCSRSCG-GGVQERGVFCPGGL------------CDWTKRPTSTMSCNE 1469
Query: 939 HVPCPATWAVGNWSQCSVTCGEGTQRRNVLCTNDTG--------VPCDEAQQPASEVTCS 990
H+ C WA GNW CS +CG G Q+R V C G CD +P C+
Sbjct: 1470 HLCCH--WATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCN 1527
Query: 991 LPLCR 995
C+
Sbjct: 1528 QQACK 1532
Score = 83.2 bits (204), Expect = 2e-15
Identities = 45/120 (37%), Positives = 62/120 (51%), Gaps = 12/120 (10%)
Query: 819 PPPVFSWHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQP 878
P P +W PW++C+ +CG GVQ + V+C G + CD RP C+E
Sbjct: 1421 PEPCEAWQVEPWSQCSRSCGGGVQERGVFC----PGGL----CDWTKRPTSTM-SCNEHL 1471
Query: 879 CPARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPCNR 938
C W G W LCS+SCG GG +R V C+ S G ++ + C+H PRPP CN+
Sbjct: 1472 C-CHWATGNWDLCSTSCG-GGFQKRTVQCVPSEG-NKTEDQDQCLCDHKPRPPEFKKCNQ 1528
Score = 57.0 bits (136), Expect = 2e-07
Identities = 33/91 (36%), Positives = 42/91 (46%), Gaps = 12/91 (13%)
Query: 881 ARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPCNRHV 940
A W G W CS++CG G RR V C + D C + RP C+
Sbjct: 1315 AHWIVGNWSECSTTCGLGAYWRR-VECSTQMDSD---------CAAIQRPDPAKRCHLR- 1363
Query: 941 PCPATWAVGNWSQCSVTCGEGTQRRNVLCTN 971
PC A W VGNWS+CS C G + R + C +
Sbjct: 1364 PC-AGWKVGNWSKCSRNCSGGFKIREIQCVD 1393
Score = 34.3 bits (77), Expect = 1.1
Identities = 19/48 (39%), Positives = 21/48 (43%), Gaps = 4/48 (8%)
Query: 1527 SSWRECSEACGGGEQ--QRLVTCPEPGLCEEAL--RPNTTRPCNTHPC 1570
S W CS CG G Q +RL PEP + R CN HPC
Sbjct: 549 SPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRLCNVHPC 596
Score = 33.5 bits (75), Expect = 1.8
Identities = 20/53 (37%), Positives = 25/53 (47%), Gaps = 8/53 (15%)
Query: 547 WSICSRSCGMGVQSAERQCTQPTPKYKGR---YCVGERK----RFRLCNLQAC 592
W +CS SCG G Q QC P+ K C+ + K F+ CN QAC
Sbjct: 1480 WDLCSTSCGGGFQKRTVQCV-PSEGNKTEDQDQCLCDHKPRPPEFKKCNQQAC 1531
>gi|64276808 ADAM metallopeptidase with thrombospondin type 1 motif, 6
preproprotein [Homo sapiens]
Length = 1117
Score = 748 bits (1930), Expect = 0.0
Identities = 413/1001 (41%), Positives = 555/1001 (55%), Gaps = 65/1001 (6%)
Query: 48 PVRVDAGGSFLSYEL----WPRALRKRDVSVRRDAPA--FYELQYRGRELRFNLTANQHL 101
P+RVD G+FLS+ + R R D + A + F++L G+ NLT N
Sbjct: 47 PIRVDQNGAFLSFTVKNDKHSRRRRSMDPIDPQQAVSKLFFKLSAYGKHFHLNLTLNTDF 106
Query: 102 LAPGFVSETRRRGGLGRAHIRAHTPACHLLGEVQDPELEGGLAAISACDGLKGVFQLSNE 161
++ F E + G H CH G +QD + A+S C GL GV +E
Sbjct: 107 VSKHFTVEYWGKDGPQWKH--DFLDNCHYTGYLQD-QRSTTKVALSNCVGLHGVIATEDE 163
Query: 162 DYFIEPLDSAPARPGH-----AQPHVVYKRQAPERLAQRGDSSAPSTCGVQVYPELESRR 216
+YFIEPL + H PHV+YK+ A Q+ S CGV + S +
Sbjct: 164 EYFIEPLKNTTEDSKHFSYENGHPHVIYKKSA----LQQRHLYDHSHCGVSDFTR--SGK 217
Query: 217 ERWEQRQQW-------RRPRLRRLHQRSVSKEKWVETLVVADAKMVEYHGQPQVESYVLT 269
W + +RSVS E++VETLVVAD MV YHG+ +E Y+L+
Sbjct: 218 PWWLNDTSTVSYSLPINNTHIHHRQKRSVSIERFVETLVVADKMMVGYHGRKDIEHYILS 277
Query: 270 IMNMVAGLFHDPSIGNPIHITIVRLVLLEDEEEDLKITHHADNTLKSFCKWQKSI---NM 326
+MN+VA L+ D S+GN ++I + RL++L +++ +L+I HHAD +L SFCKWQKSI
Sbjct: 278 VMNIVAKLYRDSSLGNVVNIIVARLIVLTEDQPNLEINHHADKSLDSFCKWQKSILSHQS 337
Query: 327 KGDAHP----LHHDTAILLTRKDLCAAMNRPCETLGLSHVAGMCQPHRSCSINEDTGLPL 382
G+ P HHD A+L+TR D+C N+PC TLGL+ VAGMC+P RSCSINED GL
Sbjct: 338 DGNTIPENGIAHHDNAVLITRYDICTYKNKPCGTLGLASVAGMCEPERSCSINEDIGLGS 397
Query: 383 AFTVAHELGHSFGIQHDGSGNDCEPVGKRPF-IMSPQLLYDAAPLTWSRCSRQYITRFLD 441
AFT+AHE+GH+FG+ HDG GN C G +M+ + + P +WS CSR YIT FLD
Sbjct: 398 AFTIAHEIGHNFGMNHDGIGNSCGTKGHEAAKLMAAHITANTNPFSWSACSRDYITSFLD 457
Query: 442 RGWGLCLDDPPAKDIIDFPSVPPGVLYDVSHQCRLQYGAYSAFCEDMDNVCHTLWC-SVG 500
G G CLD+ P K +P+V PG +YD QCR QYGA S C+ VC LWC S
Sbjct: 458 SGRGTCLDNEPPKRDFLYPAVAPGQVYDADEQCRFQYGATSRQCK-YGEVCRELWCLSKS 516
Query: 501 TTCHSKLDAAVDGTRCG----ENKWCLSGECVPVGFRPEAVDGGWSGWSAWSICSRSCGM 556
C + A +GT C E WC G+CVP G P+++DGGW WS W CSR+CG
Sbjct: 517 NRCVTNSIPAAEGTLCQTGNIEKGWCYQGDCVPFGTWPQSIDGGWGPWSLWGECSRTCGG 576
Query: 557 GVQSAERQCTQPTPKYKGRYCVGERKRFRLCNLQACPAGRPSFRHVQCSHFDAMLYKGQL 616
GV S+ R C P P G+YC+GERKR+R CN CP G FR QC+ FD M ++G+
Sbjct: 577 GVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDPCPLGSRDFREKQCADFDNMPFRGKY 636
Query: 617 HTWVPVVND-VNPCELHCRPANEYFAEKLRDAVVDGTPCYQVRASRDLCINGICKNVGCD 675
+ W P V PC L+C F + AV+DGT C S D+CING CK+VGCD
Sbjct: 637 YNWKPYTGGGVKPCALNCLAEGYNFYTERAPAVIDGTQCNA--DSLDICINGECKHVGCD 694
Query: 676 FEIDSGAMEDRCGVCHGNGSTCHTVSGTFEEAEGLG-YVDVGLIPAGAREIRIQEVAEAA 734
+ S A EDRC VC G+GSTC + G F ++ G Y++V IP G+ I ++EVA +
Sbjct: 695 NILGSDAREDRCRVCGGDGSTCDAIEGFFNDSLPRGGYMEVVQIPRGSVHIEVREVAMSK 754
Query: 735 NFLALRSEDPEKYFLNGGWTIQWNGDYQVAGTTFTYARRGNW-ENLTSPGPTKEPVWIQL 793
N++AL+SE + Y++NG WTI W + VAGT F Y R + E+L + GPT E + + +
Sbjct: 755 NYIALKSEGDD-YYINGAWTIDWPRKFDVAGTAFHYKRPTDEPESLEALGPTSENLIVMV 813
Query: 794 LFQESNPGVHYEYT--IHREAGGHDEVPPPVFSWHYGPWTKCTVTCGRGVQRQNVYCLER 851
L QE N G+ Y++ I R G +EV F+W++ PW++C+ TC GVQRQ V C
Sbjct: 814 LLQEQNLGIRYKFNVPITRTGSGDNEVG---FTWNHQPWSECSATCAGGVQRQEVVCKRL 870
Query: 852 QAGP-VDEEHCDPLGRPDDQQRKCSEQPCPARWWAGEWQLCSSSCGPGGLSRRAVLCIRS 910
V +CDP +P + QR C+ +PCP W+ G+W CS +C GG+ RAVLCIR
Sbjct: 871 DDNSIVQNNYCDPDSKPPENQRACNTEPCPPEWFIGDWLECSKTCD-GGMRTRAVLCIRK 929
Query: 911 VGLDEQSALEPPACEHLPRPPTETPCNRHVPCPATWAVGNWSQCSVTCGEGTQRRNVLCT 970
+G E+ L+ C RP + PCN CP W +WS+C+ CG G + R VLC
Sbjct: 930 IGPSEEETLDYSGCL-THRPVEKEPCNNQ-SCPPQWVALDWSECTPKCGPGFKHRIVLCK 987
Query: 971 NDT------GVPCDEAQQPASEVTCSLPLC---RWPLGTLG 1002
+ C E +P + CSL C RW G G
Sbjct: 988 SSDLSKTFPAAQCPEESKPPVRIRCSLGRCPPPRWVTGDWG 1028
Score = 127 bits (320), Expect = 7e-29
Identities = 84/277 (30%), Positives = 114/277 (41%), Gaps = 29/277 (10%)
Query: 1415 WQAGNWSECSTTCGLGAVWRPVRCSSGRDED------CAPAGR-PQPARRCHLRPC-ATW 1466
W WSECS TC G + V C D C P + P+ R C+ PC W
Sbjct: 844 WNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPPEW 903
Query: 1467 HSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPA---KPPAHRPCGAQPC-L 1522
G+W +CS++C GG R V C+ R + P +P PC Q C
Sbjct: 904 FIGDWLECSKTCDGGMRTRAVLCI--RKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCPP 961
Query: 1523 SWYTSSWRECSEACGGGEQQRLVTCPEPGL--------CEEALRPNTTRPCNTHPC--TQ 1572
W W EC+ CG G + R+V C L C E +P C+ C +
Sbjct: 962 QWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCPPPR 1021
Query: 1573 WVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPCGTE-DCEPV 1631
WV G WGQCS CG G Q R V+C+ + TG + S C P S + C ++ D P+
Sbjct: 1022 WVTGDWGQCSAQCGLGQQMRTVQCL-SYTG---QASSDCLETVRPPSMQQCESKCDSTPI 1077
Query: 1632 EPPRCERDRLSFGFCETLRLLGRCQLPTIRTQCCRSC 1668
+D +C + C R CC++C
Sbjct: 1078 SNTEECKDVNKVAYCPLVLKFKFCSRAYFRQMCCKTC 1114
Score = 102 bits (253), Expect = 4e-21
Identities = 69/229 (30%), Positives = 97/229 (42%), Gaps = 28/229 (12%)
Query: 1465 TWHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAHRPCGAQPC-LS 1523
TW+ WS+CS +C GG ++V C D ++ +C P P R C +PC
Sbjct: 843 TWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPPE 902
Query: 1524 WYTSSWRECSEACGGGEQQRLVTC-PEPGLCEEAL---------RPNTTRPCNTHPC-TQ 1572
W+ W ECS+ C GG + R V C + G EE RP PCN C Q
Sbjct: 903 WFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCPPQ 962
Query: 1573 WVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPCGTEDCEPVE 1632
WV W +C+ CG G + R+V C ++ + QC E+ P C C
Sbjct: 963 WVALDWSECTPKCGPGFKHRIVLCKSSDLS-KTFPAAQCPEESKPPVRIRCSLGRC---P 1018
Query: 1633 PPRCERDRLSFGFCETLRLLGRCQLPTIR---------TQCCRSCSPPS 1672
PPR +G C LG+ Q+ T++ + C + PPS
Sbjct: 1019 PPRWVTG--DWGQCSAQCGLGQ-QMRTVQCLSYTGQASSDCLETVRPPS 1064
Score = 80.9 bits (198), Expect = 1e-14
Identities = 61/200 (30%), Positives = 83/200 (41%), Gaps = 23/200 (11%)
Query: 1384 NSHRVPETQPLAPSLAEAGPPADPLVVRNAGWQAGNWSECSTTCGLGAVWRPVRC----S 1439
N++ P+++P A P P W G+W ECS TC G R V C
Sbjct: 878 NNYCDPDSKPPENQRACNTEPCPP------EWFIGDWLECSKTCDGGMRTRAVLCIRKIG 931
Query: 1440 SGRDEDCAPAG----RPQPARRCHLRPC-ATWHSGNWSKCSRSCGGGSSVRDVQCVDTRD 1494
+E +G RP C+ + C W + +WS+C+ CG G R V C + D
Sbjct: 932 PSEEETLDYSGCLTHRPVEKEPCNNQSCPPQWVALDWSECTPKCGPGFKHRIVLC-KSSD 990
Query: 1495 LRPLRPFHCQPGPAKPPAHRPC--GAQPCLSWYTSSWRECSEACGGGEQQRLVTC----- 1547
L P P +KPP C G P W T W +CS CG G+Q R V C
Sbjct: 991 LSKTFPAAQCPEESKPPVRIRCSLGRCPPPRWVTGDWGQCSAQCGLGQQMRTVQCLSYTG 1050
Query: 1548 PEPGLCEEALRPNTTRPCNT 1567
C E +RP + + C +
Sbjct: 1051 QASSDCLETVRPPSMQQCES 1070
Score = 34.3 bits (77), Expect = 1.1
Identities = 20/48 (41%), Positives = 21/48 (43%), Gaps = 4/48 (8%)
Query: 1527 SSWRECSEACGGGEQQRLVTCPEP---GLCEEAL-RPNTTRPCNTHPC 1570
S W ECS CGGG L C P G + L R CNT PC
Sbjct: 565 SLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDPC 612
Score = 32.7 bits (73), Expect = 3.1
Identities = 18/51 (35%), Positives = 22/51 (43%), Gaps = 5/51 (9%)
Query: 1578 WGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPCGTEDC 1628
WG+CS CGGGV L C + P C E + R C T+ C
Sbjct: 567 WGECSRTCGGGVSSSLRHC---DSPAPSGGGKYCLGER--KRYRSCNTDPC 612
Score = 32.3 bits (72), Expect = 4.0
Identities = 37/135 (27%), Positives = 49/135 (36%), Gaps = 23/135 (17%)
Query: 1412 NAGWQAGN-WSECSTTCGLGAVWRPVRCS----SGRDEDCAPAGRPQPARRCHLRPCATW 1466
+ GW + W ECS TCG G C SG + C G + R C+ PC
Sbjct: 558 DGGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYC--LGERKRYRSCNTDPCPL- 614
Query: 1467 HSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAHRPCGAQPCLSWYT 1526
G R+ QC D D P R + P +PC A CL+
Sbjct: 615 -------------GSRDFREKQCADF-DNMPFRGKYYNWKPYTGGGVKPC-ALNCLAEGY 659
Query: 1527 SSWRECSEACGGGEQ 1541
+ + E + A G Q
Sbjct: 660 NFYTERAPAVIDGTQ 674
>gi|56121815 ADAM metallopeptidase with thrombospondin type 1 motif,
10 preproprotein [Homo sapiens]
Length = 1103
Score = 681 bits (1756), Expect = 0.0
Identities = 400/1004 (39%), Positives = 530/1004 (52%), Gaps = 75/1004 (7%)
Query: 44 DIVHPVRVDAGGSFLSYELWPRALRKRDVSVRRDAPAFYELQYRGRELRFNLTANQHLLA 103
+I P RVD G+ L++ P ++R ++ FY++ NLT + LLA
Sbjct: 40 EIAFPTRVDHNGALLAFSPPPPRRQRRGTGATAESRLFYKVASPSTHFLLNLTRSSRLLA 99
Query: 104 PGFVSETRRRGGLGRAHIRAHTPACHLLGEVQDPELEGGLAAISACDGLKGVFQLSNEDY 163
E R GL A RA P C G +Q + AIS C GL G+ E+Y
Sbjct: 100 GHVSVEYWTREGL--AWQRAARPHCLYAGHLQG-QASTSHVAISTCGGLHGLIVADEEEY 156
Query: 164 FIEPLDSAPA---RPGHAQPHVVYKRQAPERLAQRGDSSAPSTCGVQVYPELESRRERWE 220
IEPL P P + PHVVYKR + + CGV+ + W+
Sbjct: 157 LIEPLHGGPKGSRSPEESGPHVVYKRSSLRH------PHLDTACGVR-------DEKPWK 203
Query: 221 QRQQWRR----PRLRRLH----------QRSVSKEKWVETLVVADAKMVEYHGQPQVESY 266
R W R P R L +RSVS+E++VETLVVAD MV YHG+ VE Y
Sbjct: 204 GRPWWLRTLKPPPARPLGNETERGQPGLKRSVSRERYVETLVVADKMMVAYHGRRDVEQY 263
Query: 267 VLTIMNMVAGLFHDPSIGNPIHITIVRLVLLEDEEEDLKITHHADNTLKSFCKWQKSI-- 324
VL IMN+VA LF D S+G+ ++I + RL+LL +++ L+ITHHA +L SFCKWQKSI
Sbjct: 264 VLAIMNIVAKLFQDSSLGSTVNILVTRLILLTEDQPTLEITHHAGKSLDSFCKWQKSIVN 323
Query: 325 -NMKGDAHP----LHHDTAILLTRKDLCAAMNRPCETLGLSHVAGMCQPHRSCSINEDTG 379
+ G+A P +HDTA+L+TR D+C N+PC TLGL+ V GMC+ RSCS+NED G
Sbjct: 324 HSGHGNAIPENGVANHDTAVLITRYDICIYKNKPCGTLGLAPVGGMCERERSCSVNEDIG 383
Query: 380 LPLAFTVAHELGHSFGIQHDGSGNDCEPVGKRPF-IMSPQLLYDAAPLTWSRCSRQYITR 438
L AFT+AHE+GH+FG+ HDG GN C G+ P +M+ + P WS CSR YIT
Sbjct: 384 LATAFTIAHEIGHTFGMNHDGVGNSCGARGQDPAKLMAAHITMKTNPFVWSSCSRDYITS 443
Query: 439 FLDRGWGLCLDDPPAKDIIDFPSVPPGVLYDVSHQCRLQYGAYSAFCEDMDNVCHTLWC- 497
FLD G GLCL++ P + +P+V PG YD QCR Q+G S C+ VC LWC
Sbjct: 444 FLDSGLGLCLNNRPPRQDFVYPTVAPGQAYDADEQCRFQHGVKSRQCK-YGEVCSELWCL 502
Query: 498 SVGTTCHSKLDAAVDGTRCG----ENKWCLSGECVPVGFRPEAVDGGWSGWSAWSICSRS 553
S C + A +GT C + WC CVP G RPE VDG W W+ W CSR+
Sbjct: 503 SKSNRCITNSIPAAEGTLCQTHTIDKGWCYKRVCVPFGSRPEGVDGAWGPWTPWGDCSRT 562
Query: 554 CGMGVQSAERQCTQPTPKYKGRYCVGERKRFRLCNLQACPAGRPSFRHVQCSHFDAMLYK 613
CG GV S+ R C P P G+YC+GER+R R CN CP G FR VQCS FD++ ++
Sbjct: 563 CGGGVSSSSRHCDSPRPTIGGKYCLGERRRHRSCNTDDCPPGSQDFREVQCSEFDSIPFR 622
Query: 614 GQLHTWVPV-VNDVNPCELHCRPANEYFAEKLRDAVVDGTPCYQVRASRDLCINGICKNV 672
G+ + W V C L C F + AVVDGTPC + D+C++G CK+V
Sbjct: 623 GKFYKWKTYRGGGVKACSLTCLAEGFNFYTERAAAVVDGTPCRP--DTVDICVSGECKHV 680
Query: 673 GCDFEIDSGAMEDRCGVCHGNGSTCHTVSGTFEEAE-GLGYVDVGLIPAGAREIRIQEVA 731
GCD + S ED+C VC G+GS C T+ G F A G GY DV IP G+ I IQ++
Sbjct: 681 GCDRVLGSDLREDKCRVCGGDGSACETIEGVFSPASPGAGYEDVVWIPKGSVHIFIQDLN 740
Query: 732 EAANFLALRSEDPEKYFLNGGWTIQWNGDYQVAGTTFTYARRG--NWENLTSPGPTKEPV 789
+ + LAL+ D E L G +AGTTF R+G ++L + GP +
Sbjct: 741 LSLSHLALKG-DQESLLLEGLPGTPQPHRLPLAGTTF-QLRQGPDQVQSLEALGPINASL 798
Query: 790 WIQLLFQESNPGVHYEYTIHREAGGHDEVPPPVFSWHYGPWTKCTVTCGRGVQRQNVYCL 849
+ +L + P + Y + D +PP +SWHY PWTKC+ C G Q Q V C
Sbjct: 799 IVMVLARTELPALRYRF---NAPIARDSLPP--YSWHYAPWTKCSAQCAGGSQVQAVECR 853
Query: 850 ER-QAGPVDEEHCDPLGRPDDQQRKCSEQPCPARWWAGEWQLCSSSCGPGGLSRRAVLCI 908
+ + V +C + +QR C+ +PCP W G W LCS SC G+ R+V+C
Sbjct: 854 NQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPPDWVVGNWSLCSRSC-DAGVRSRSVVCQ 912
Query: 909 RSVGLDEQSALEPPACEHLPRPPTETPCNRHVP-CPATWAVGNWSQCSVTCGEGTQRRNV 967
R V E+ AL+ AC PRPP C H P CP WA +WS+C+ +CG G + R V
Sbjct: 913 RRVSAAEEKALDDSACPQ-PRPPVLEAC--HGPTCPPEWAALDWSECTPSCGPGLRHRVV 969
Query: 968 LCTND------TGVPCDEAQQPASEVTCSLPLC---RWPLGTLG 1002
LC + C A +P + + C+L C RW G G
Sbjct: 970 LCKSADHRATLPPAHCSPAAKPPATMRCNLRRCPPARWVAGEWG 1013
Score = 135 bits (341), Expect = 3e-31
Identities = 112/383 (29%), Positives = 154/383 (40%), Gaps = 66/383 (17%)
Query: 1327 LQTVAVWGTFLPTTLTGLGHMPEP----------ALNPGPKGQPESLSPEVPLSSRLLST 1376
L +A+ G L GL P+P L GP Q +SL P+++ L+
Sbjct: 743 LSHLALKGDQESLLLEGLPGTPQPHRLPLAGTTFQLRQGPD-QVQSLEALGPINASLIVM 801
Query: 1377 --PAWDSPANSHRVPETQPLAPSLAEAGPPADPLVVRNAGWQAGNWSECSTTCGLGAVWR 1434
+ PA +R AP ++ PP W W++CS C G+ +
Sbjct: 802 VLARTELPALRYRFN-----APIARDSLPPYS--------WHYAPWTKCSAQCAGGSQVQ 848
Query: 1435 PVRCSSGRDEDC-------APAGRPQPARRCHLRPCAT-WHSGNWSKCSRSCGGGSSVRD 1486
V C + D A + P+ R C+ PC W GNWS CSRSC G R
Sbjct: 849 AVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPPDWVVGNWSLCSRSCDAGVRSRS 908
Query: 1487 VQC---VDTRDLRPLRPFHCQPGPAKPPAHRPCGAQPCL-SWYTSSWRECSEACGGGEQQ 1542
V C V + + L C P P +PP C C W W EC+ +CG G +
Sbjct: 909 VVCQRRVSAAEEKALDDSAC-PQP-RPPVLEACHGPTCPPEWAALDWSECTPSCGPGLRH 966
Query: 1543 RLVTCPE--------PGLCEEALRPNTTRPCNTHPC--TQWVVGPWGQCSGPCGGGVQRR 1592
R+V C P C A +P T CN C +WV G WG+CS CG G ++R
Sbjct: 967 RVVLCKSADHRATLPPAHCSPAAKPPATMRCNLRRCPPARWVAGEWGECSAQCGVGQRQR 1026
Query: 1593 LVKCVNTQTGLPEEDSDQCGHEAWPESSRPCGTEDCE-------PVEPPRCERDRLSFGF 1645
V+C + TG Q HE E+ RP T+ CE P + P +D +
Sbjct: 1027 SVRC-TSHTG-------QASHEC-TEALRPPTTQQCEAKCDSPTPGDGPEECKDVNKVAY 1077
Query: 1646 CETLRLLGRCQLPTIRTQCCRSC 1668
C + C R CC++C
Sbjct: 1078 CPLVLKFQFCSRAYFRQMCCKTC 1100
Score = 36.6 bits (83), Expect = 0.21
Identities = 20/54 (37%), Positives = 23/54 (42%), Gaps = 5/54 (9%)
Query: 1577 PWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPCGTEDCEP 1630
PWG CS CGGGV C + + P C E R C T+DC P
Sbjct: 555 PWGDCSRTCGGGVSSSSRHCDSPR---PTIGGKYCLGER--RRHRSCNTDDCPP 603
>gi|40806187 ADAM metallopeptidase with thrombospondin type 1 motif,
18 preproprotein [Homo sapiens]
Length = 1221
Score = 645 bits (1663), Expect = 0.0
Identities = 377/1055 (35%), Positives = 540/1055 (51%), Gaps = 84/1055 (7%)
Query: 3 GGPSPRSPAPLLR--PLLLLLCALAPGAPGPAPGRATEGRAALD----IVHPVRVDAGGS 56
G PR A L R L L C ++ G + L+ V PV VD+ GS
Sbjct: 15 GSGPPRGLAGLGRVAKALQLCCLCCASVAAALASDSSSGASGLNDDYVFVTPVEVDSAGS 74
Query: 57 FLSYELWPRALRKRDVSVRRDAPAFYELQYRGRELRFNLTANQHLLAPGFVSETRRRGGL 116
++S+++ +KR R + Y G+EL L + +L+ F+ + + G
Sbjct: 75 YISHDILHNGRKKRSAQNARSS-LHYRFSAFGQELHLELKPSA-ILSSHFIVQVLGKDGA 132
Query: 117 GRAHIRAHTPACHLLGEVQDPELEGGLAAISACDGLKGVFQLSNEDYFIEPLDSAPAR-- 174
+ C G +++ A+S C GL G+ + ++ I PL A+
Sbjct: 133 SETQ-KPEVQQCFYQGFIRNDSSSS--VAVSTCAGLSGLIRTRKNEFLISPLPQLLAQEH 189
Query: 175 ----PGHAQPHVVYKRQAPERLAQRGDSSAPSTCGVQVYPELESRRERWEQRQQWRRPRL 230
P PHV+YKR A E++ QR S Y + ++ RL
Sbjct: 190 NYSSPAGHHPHVLYKRTAEEKI-QRYRGYPGSGRNYPGYSPSHIPHASQSRETEYHHRRL 248
Query: 231 RRLH------------------------------QRSVSKEKW---VETLVVADAKMVEY 257
++ H +RS K + VETLVVAD KMVE
Sbjct: 249 QKQHFCGRRKKYAPKPPTEDTYLRFDEYGSSGRPRRSAGKSQKGLNVETLVVADKKMVEK 308
Query: 258 HGQPQVESYVLTIMNMVAGLFHDPSIGNPIHITIVRLVLLEDEEEDLKITHHADNTLKSF 317
HG+ V +Y+LT+MNMV+GLF D +IG+ I++ +V L+LLE E L I HHAD +L SF
Sbjct: 309 HGKGNVTTYILTVMNMVSGLFKDGTIGSDINVVVVSLILLEQEPGGLLINHHADQSLNSF 368
Query: 318 CKWQKSINMKGDAHPLHHDTAILLTRKDLCAAMNRPCETLGLSHVAGMCQPHRSCSINED 377
C+WQ ++ K HD AILLT D+C+ N PC+TLG + ++GMC +RSC+INED
Sbjct: 369 CQWQSALIGKNGKR---HDHAILLTGFDICSWKNEPCDTLGFAPISGMCSKYRSCTINED 425
Query: 378 TGLPLAFTVAHELGHSFGIQHDGSGNDCEPVGKRPFIMSPQLLYDAAPLTWSRCSRQYIT 437
TGL LAFT+AHE GH+FG+ HDG GN C IMSP L + +WS CSRQY+
Sbjct: 426 TGLGLAFTIAHESGHNFGMIHDGEGNPCRKAEGN--IMSPTLTGNNGVFSWSSCSRQYLK 483
Query: 438 RFLDRGWGLCL-DDPPAKDIIDFPSVPPGVLYDVSHQCRLQYGAYSAFCE--DMDNVCHT 494
+FL CL D+P +P PG +YD QC+ Q+GA + C + ++C +
Sbjct: 484 KFLSTPQAGCLVDEPKQAGQYKYPDKLPGQIYDADTQCKWQFGAKAKLCSLGFVKDICKS 543
Query: 495 LWC-SVGTTCHSKLDAAVDGTRCGENKWCLSGECVPVG-FRPEAVDGGWSGWSAWSICSR 552
LWC VG C +K A +GT CG + WC G+CV G P + G WS WS WS CSR
Sbjct: 544 LWCHRVGHRCETKFMPAAEGTVCGLSMWCRQGQCVKFGELGPRPIHGQWSAWSKWSECSR 603
Query: 553 SCGMGVQSAERQCTQPTPKYKGRYCVGERKRFRLCNLQACPAGRPSFRHVQCSHFDAMLY 612
+CG GV+ ER C P P+Y G +C G + ++LCN+ C FR QC+ +++ +
Sbjct: 604 TCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNENSLDFRAQQCAEYNSKPF 663
Query: 613 KGQLHTWVPV--VNDVNPCELHCRPANEYFAEKLRDAVVDGTPCYQVRASRDLCINGICK 670
+G + W P V + + C+L+C+ N F + V DGTPC + D+CI+G+C+
Sbjct: 664 RGWFYQWKPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTPCSPNK--NDVCIDGVCE 721
Query: 671 NVGCDFEIDSGAMEDRCGVCHGNGSTCHTVSGTF-EEAEGLGYVDVGLIPAGAREIRIQE 729
VGCD E+ S A+ D CGVC G+ STC G + + + Y V LIPAGAR I IQE
Sbjct: 722 LVGCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKANEYYPVVLIPAGARSIEIQE 781
Query: 730 VAEAANFLALRSEDPEKYFLNGGWTIQWNGDYQVAGTTFTYARRGNW-ENLTSPGPTKEP 788
+ ++++LA+RS +KY+L GGW+I W G++ AGTTF Y R N E L +PGPT E
Sbjct: 782 LQVSSSYLAVRSLS-QKYYLTGGWSIDWPGEFPFAGTTFEYQRSFNRPERLYAPGPTNET 840
Query: 789 VWIQLLFQESNPGVHYEYTIHREAGGHDEVPP----PVFSWHYGPWTKCTVTCGRGVQRQ 844
+ ++L Q NPG+ ++Y + + G PP P ++W ++C+V+CG G
Sbjct: 841 LVFEILMQGKNPGIAWKYALPKVMNG---TPPATKRPAYTWSI-VQSECSVSCGGGYINV 896
Query: 845 NVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQPCPARWWAGEWQLCSSSCGPGGLSRRA 904
CL Q V+ C +P + + C+ CPA W GEW CS +C GG R
Sbjct: 897 KAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWSTCSKACA-GGQQSRK 955
Query: 905 VLCIRSVGLDEQSALEPPACEHLPRPPTETPCNRHVPCPATWAVGNWSQCSVTCGEGTQR 964
+ C++ ++ A+ C + P CN H CP W++G WSQCS TCG G ++
Sbjct: 956 IQCVQKKPFQKEEAVLHSLCP-VSTPTQVQACNSHA-CPPQWSLGPWSQCSKTCGRGVRK 1013
Query: 965 RNVLCTNDTGVPCDEAQ-----QPASEVTCSLPLC 994
R +LC E+Q +P + C L C
Sbjct: 1014 RELLCKGSAAETLPESQCTSLPRPELQEGCVLGRC 1048
Score = 129 bits (323), Expect = 3e-29
Identities = 93/296 (31%), Positives = 114/296 (38%), Gaps = 49/296 (16%)
Query: 1413 AGWQAGNWSECSTTCGLGAVWRPVRCSSGRD--------EDCAPAGRPQPARRCHLRPCA 1464
A W G WS CS C G R ++C + P P + C+ C
Sbjct: 933 AYWMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACP 992
Query: 1465 T-WHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAHRPCGAQPC-- 1521
W G WS+CS++CG G R++ C + L C P +P C C
Sbjct: 993 PQWSLGPWSQCSKTCGRGVRKRELLCKGSA-AETLPESQCTSLP-RPELQEGCVLGRCPK 1050
Query: 1522 ---LSWYTSSWRECSEACGGGEQQRLVTCPEPGL-----------CEEALRPN------- 1560
L W SSW ECS CG G ++R + C E G C +PN
Sbjct: 1051 NSRLQWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETC 1110
Query: 1561 TTRPCNTHPCTQWVVG----PWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAW 1616
R C HP V G PW QC+ CGGGVQ R V CV Q G P S C
Sbjct: 1111 NRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCV--QQGRP---SSSCLLHQK 1165
Query: 1617 PESSRPCGTEDC---EPVEPPRCERDRLSFGFCETLRLLGRCQLPTIRTQCCRSCS 1669
P R C T C E E P C F +C + G C QCC+SC+
Sbjct: 1166 PPVLRACNTNFCPAPEKREDPSCVD---FFNWCHLVPQHGVCNHKFYGKQCCKSCT 1218
Score = 98.6 bits (244), Expect = 5e-20
Identities = 70/223 (31%), Positives = 96/223 (43%), Gaps = 30/223 (13%)
Query: 820 PPVFSWHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQPC 879
PP W GPW++C+ TCGRGV+++ + C A + E C L RP+ Q+ C C
Sbjct: 992 PP--QWSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEG-CVLGRC 1048
Query: 880 PA----RWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRP--PTE 933
P +W A W CS++CG G + +R + C + C ++ +P E
Sbjct: 1049 PKNSRLQWVASSWSECSATCGLG-VRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLE 1107
Query: 934 TPCNRHVPCPAT--------WAVGNWSQCSVTCGEGTQRRNVLCTNDTGVP---CDEAQQ 982
CNR CPA W W QC+VTCG G Q R+V C G P C Q+
Sbjct: 1108 ETCNRRA-CPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQQ-GRPSSSCLLHQK 1165
Query: 983 PASEVTCSLPLCRWPLGTLGPEGSGSGSSSHELFNEADFIPHH 1025
P C+ C P P S + FN +P H
Sbjct: 1166 PPVLRACNTNFCPAPEKREDP-------SCVDFFNWCHLVPQH 1201
Score = 93.6 bits (231), Expect = 1e-18
Identities = 61/200 (30%), Positives = 87/200 (43%), Gaps = 27/200 (13%)
Query: 1421 SECSTTCGLGAVWRPVRCSSGRDED-------CAPAGRPQPARR-CHLRPC-ATWHSGNW 1471
SECS +CG G + V+ RD++ C+ +P + C+ C A W G W
Sbjct: 883 SECSVSCGGGYI--NVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEW 940
Query: 1472 SKCSRSCGGGSSVRDVQCVDTRDLRPLRP-FHCQPGPAKPPAHRPCGAQPC-LSWYTSSW 1529
S CS++C GG R +QCV + + H + P + C + C W W
Sbjct: 941 STCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPW 1000
Query: 1530 RECSEACGGGEQQRLVTC--------PEPGLCEEALRPNTTRPCNTHPC-----TQWVVG 1576
+CS+ CG G ++R + C PE C RP C C QWV
Sbjct: 1001 SQCSKTCGRGVRKRELLCKGSAAETLPE-SQCTSLPRPELQEGCVLGRCPKNSRLQWVAS 1059
Query: 1577 PWGQCSGPCGGGVQRRLVKC 1596
W +CS CG GV++R +KC
Sbjct: 1060 SWSECSATCGLGVRKREMKC 1079
Score = 87.8 bits (216), Expect = 8e-17
Identities = 47/153 (30%), Positives = 71/153 (46%), Gaps = 14/153 (9%)
Query: 825 WHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDE---EHCDPLGRPDDQQRKCSEQPCPA 881
W G W+ C+ C G Q + + C++++ +E P+ P Q + C+ CP
Sbjct: 935 WMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPT-QVQACNSHACPP 993
Query: 882 RWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPCNRHVP 941
+W G W CS +CG G + +R +LC S L C LPRP + C
Sbjct: 994 QWSLGPWSQCSKTCGRG-VRKRELLCKGSAA----ETLPESQCTSLPRPELQEGCVLG-R 1047
Query: 942 CPAT----WAVGNWSQCSVTCGEGTQRRNVLCT 970
CP W +WS+CS TCG G ++R + C+
Sbjct: 1048 CPKNSRLQWVASSWSECSATCGLGVRKREMKCS 1080
Score = 47.4 bits (111), Expect = 1e-04
Identities = 30/82 (36%), Positives = 41/82 (50%), Gaps = 4/82 (4%)
Query: 800 PGVHYEYTIHREAGGHDEVPPPVFSWHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEE 859
P + E T +R A V V W+ PW +CTVTCG GVQ ++V+C++ Q P
Sbjct: 1102 PNLDLEETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQ-QGRP--SS 1158
Query: 860 HCDPLGRPDDQQRKCSEQPCPA 881
C L + R C+ CPA
Sbjct: 1159 SC-LLHQKPPVLRACNTNFCPA 1179
Score = 40.8 bits (94), Expect = 0.011
Identities = 22/62 (35%), Positives = 28/62 (45%), Gaps = 2/62 (3%)
Query: 1404 PADPLVVRNAGWQAGNWSECSTTCGLGAVWRPVRC-SSGR-DEDCAPAGRPQPARRCHLR 1461
PA P+ AGW + W +C+ TCG G R V C GR C +P R C+
Sbjct: 1116 PAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLLHQKPPVLRACNTN 1175
Query: 1462 PC 1463
C
Sbjct: 1176 FC 1177
Score = 38.9 bits (89), Expect = 0.043
Identities = 20/61 (32%), Positives = 32/61 (52%), Gaps = 13/61 (21%)
Query: 545 SAWSICSRSCGMGVQSAERQCTQPTPKYKGRYCVGERKRFR-----------LCNLQACP 593
S+WS CS +CG+GV+ E +C++ ++G+ +R R CN +ACP
Sbjct: 1059 SSWSECSATCGLGVRKREMKCSE--KGFQGKLITFPERRCRNIKKPNLDLEETCNRRACP 1116
Query: 594 A 594
A
Sbjct: 1117 A 1117
Score = 36.6 bits (83), Expect = 0.21
Identities = 34/101 (33%), Positives = 42/101 (41%), Gaps = 27/101 (26%)
Query: 1478 CGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAHRPCGAQPCLSWYTSSWRECSEACG 1537
CG R QCV +L P RP H Q +W S W ECS CG
Sbjct: 566 CGLSMWCRQGQCVKFGELGP-RPIHGQWS----------------AW--SKWSECSRTCG 606
Query: 1538 GGE--QQRLVTCPEP---GL-CEEALRPNTTRPCNTHPCTQ 1572
GG Q+R P+P GL C + R + CN +PC +
Sbjct: 607 GGVKFQERHCNNPKPQYGGLFCPGSSR--IYQLCNINPCNE 645
Score = 33.5 bits (75), Expect = 1.8
Identities = 29/98 (29%), Positives = 43/98 (43%), Gaps = 19/98 (19%)
Query: 1425 TTCGLGAVWRPVRCSSGRDEDCAPAGRPQPARRCHLRPCATWHS-GNWSKCSRSCGGGSS 1483
T CGL ++W C G+ C G P R H W + WS+CSR+CGGG
Sbjct: 564 TVCGL-SMW----CRQGQ---CVKFGELGP-RPIH----GQWSAWSKWSECSRTCGGGVK 610
Query: 1484 VRDVQCVDTRDLRPLRPFHCQPGPAKPPAHRPCGAQPC 1521
++ C + +P PG ++ ++ C PC
Sbjct: 611 FQERHC---NNPKPQYGGLFCPGSSR--IYQLCNINPC 643
Score = 32.0 bits (71), Expect = 5.2
Identities = 16/52 (30%), Positives = 26/52 (50%), Gaps = 3/52 (5%)
Query: 1415 WQA-GNWSECSTTCGLGAVWRPVRCSSGRDE--DCAPAGRPQPARRCHLRPC 1463
W A WSECS TCG G ++ C++ + + G + + C++ PC
Sbjct: 592 WSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPC 643
Score = 32.0 bits (71), Expect = 5.2
Identities = 17/55 (30%), Positives = 23/55 (41%), Gaps = 2/55 (3%)
Query: 542 SGWSA--WSICSRSCGMGVQSAERQCTQPTPKYKGRYCVGERKRFRLCNLQACPA 594
+GW + W C+ +CG GVQ+ C Q + R CN CPA
Sbjct: 1125 AGWYSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLLHQKPPVLRACNTNFCPA 1179
>gi|110735441 ADAM metallopeptidase with thrombospondin type 1 motif,
16 preproprotein [Homo sapiens]
Length = 1224
Score = 639 bits (1649), Expect = 0.0
Identities = 379/1034 (36%), Positives = 529/1034 (51%), Gaps = 76/1034 (7%)
Query: 23 ALAPGAPG---PAPGRATEG---RAALDIVHPVRVDAGGSFLSYELWPRALRKRDVSVRR 76
A APG+P P P G + D+V VD G ++S+E+ R+R V V
Sbjct: 34 AAAPGSPSVPRPPPPAERPGWMEKGEYDLVSAYEVDHRGDYVSHEIMHHQRRRRAVPVSE 93
Query: 77 DAPAFYELQYRGRELRFNLTANQHLLAPGFVSETRRRGGLGRAHIRAHTPACHLLGEVQD 136
L+ + +L + L+APGF+ +T + G C G ++
Sbjct: 94 VESLHLRLKGSRHDFHMDLRTSSSLVAPGFIVQTLGKTGTKSVQTLPPEDFCFYQGSLRS 153
Query: 137 PELEGGLAAISACDGLKGVFQLSNEDYFIEPLDS------APARPGHAQPHVVYKRQAPE 190
A+S C GL G+ + DYF+ PL S A G + HV+YKR
Sbjct: 154 HR--NSSVALSTCQGLSGMIRTEEADYFLRPLPSHLSWKLGRAAQGSSPSHVLYKRSTEP 211
Query: 191 RLAQRGDSSAPSTCGVQVYPELESRRERW--EQRQQWRRPRLRRL--------------- 233
+ S + L S R Q+Q + R + +
Sbjct: 212 HAPGASEVLVTSRTWELAHQPLHSSDLRLGLPQKQHFCGRRKKYMPQPPKEDLFILPDEY 271
Query: 234 -----HQRSV-----SKEKWVETLVVADAKMVEYHGQPQVESYVLTIMNMVAGLFHDPSI 283
H+RS+ ++E VETLVV D KM++ HG + +YVLTI+NMV+ LF D +I
Sbjct: 272 KSCLRHKRSLLRSHRNEELNVETLVVVDKKMMQNHGHENITTYVLTILNMVSALFKDGTI 331
Query: 284 GNPIHITIVRLVLLEDEEEDLKITHHADNTLKSFCKWQKSINMKGDAHPLHHDTAILLTR 343
G I+I IV L+LLEDE+ L I+HHAD+TL SFC+WQ + K HD AILLT
Sbjct: 332 GGNINIAIVGLILLEDEQPGLVISHHADHTLSSFCQWQSGLMGKDGTR---HDHAILLTG 388
Query: 344 KDLCAAMNRPCETLGLSHVAGMCQPHRSCSINEDTGLPLAFTVAHELGHSFGIQHDGSGN 403
D+C+ N PC+TLG + ++GMC +RSC+INEDTGL LAFT+AHE GH+FG+ HDG GN
Sbjct: 389 LDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGN 448
Query: 404 DCEPVGKRPFIMSPQLLYDAAPLTWSRCSRQYITRFLDRGWGLCL-DDPPAKDIIDFPSV 462
C+ IMSP L +WS CSRQY+ +FL +CL D P +P
Sbjct: 449 MCKK--SEGNIMSPTLAGRNGVFSWSPCSRQYLHKFLSTAQAICLADQPKPVKEYKYPEK 506
Query: 463 PPGVLYDVSHQCRLQYGAYSAFC--EDMDNVCHTLWC-SVGTTCHSKLDAAVDGTRCGEN 519
PG LYD + QC+ Q+G + C + ++C LWC +G C +K A +GT CG +
Sbjct: 507 LPGELYDANTQCKWQFGEKAKLCMLDFKKDICKALWCHRIGRKCETKFMPAAEGTICGHD 566
Query: 520 KWCLSGECVPVGFR-PEAVDGGWSGWSAWSICSRSCGMGVQSAERQCTQPTPKYKGRYCV 578
WC G+CV G P+ G WS WS+WS CSR+CG GV R CT P P + G++C
Sbjct: 567 MWCRGGQCVKYGDEGPKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCE 626
Query: 579 GERKRFRLCNLQACPAGRPSFRHVQCSHFDAMLYKGQLHTWVPV--VNDVNPCELHCRPA 636
G + +LCN Q CP FR QC+ ++ ++G+ + W P V D + C+L+C
Sbjct: 627 GSTRTLKLCNSQKCPRDSVDFRAAQCAEHNSRRFRGRHYKWKPYTQVEDQDLCKLYCIAE 686
Query: 637 NEYFAEKLRDAVVDGTPCYQVRASRDLCINGICKNVGCDFEIDSGAMEDRCGVCHGNGST 696
F L + V DGTPC + SR++CI+GIC+ VGCD + S A+ED CGVC+GN S
Sbjct: 687 GFDFFFSLSNKVKDGTPCSE--DSRNVCIDGICERVGCDNVLGSDAVEDVCGVCNGNNSA 744
Query: 697 CHTVSGTFEEAEGLG-YVDVGLIPAGAREIRIQEVAEAANFLALRSEDPEKYFLNGGWTI 755
C G + + Y + IP+GAR IRI E+ + +++++R+ +Y+LNG WT+
Sbjct: 745 CTIHRGLYTKHHHTNQYYHMVTIPSGARSIRIYEMNVSTSYISVRNA-LRRYYLNGHWTV 803
Query: 756 QWNGDYQVAGTTFTYARRGNW-ENLTSPGPTKEPVWIQLLFQESNPGVHYEYTIHREAGG 814
W G Y+ +GTTF Y R N ENL + GPT E + ++LLFQ NPGV +EY++ R G
Sbjct: 804 DWPGRYKFSGTTFDYRRSYNEPENLIATGPTNETLIVELLFQGRNPGVAWEYSMPRL--G 861
Query: 815 HDEVPP--PVFSWHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQR 872
++ PP P ++W ++C+V+CG G C V+ C+P RP
Sbjct: 862 TEKQPPAQPSYTWAI-VRSECSVSCGGGQMTVREGCYRDLKFQVNMSFCNPKTRPVTGLV 920
Query: 873 KCSEQPCPARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPT 932
C CP W G W CS +CG GG R V C R V D + P + P P +
Sbjct: 921 PCKVSACPPSWSVGNWSACSRTCG-GGAQSRPVQCTRRVHYDSEPV--PASLCPQPAPSS 977
Query: 933 ETPCNRHVPCPATWAVGNWSQCSVTCGEGTQRRNVLC--TNDTG-------VPCDEAQQP 983
CN CP W+ G W++CS TCG+G ++R V C TN + C +P
Sbjct: 978 RQACNSQ-SCPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKP 1036
Query: 984 ASEVTCSLPLCRWP 997
C L C P
Sbjct: 1037 RMHEACLLQRCHKP 1050
Score = 141 bits (356), Expect = 5e-33
Identities = 102/325 (31%), Positives = 134/325 (41%), Gaps = 59/325 (18%)
Query: 1389 PETQP---LAPSLAEAGPPADPLVVRNAGWQAGNWSECSTTCGLGAVWRPVRCSSGRDED 1445
P+T+P L P A PP+ W GNWS CS TCG GA RPV+C+ D
Sbjct: 911 PKTRPVTGLVPCKVSACPPS---------WSVGNWSACSRTCGGGAQSRPVQCTRRVHYD 961
Query: 1446 CAPAGR---PQPA----RRCHLRPCA-TWHSGNWSKCSRSCGGGSSVRDVQCVDTRDLR- 1496
P PQPA + C+ + C W +G W++CS +CG G R V C T
Sbjct: 962 SEPVPASLCPQPAPSSRQACNSQSCPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSAR 1021
Query: 1497 -PLRPFHCQPGPAKPPAHRPCGAQPC-----LSWYTSSWRECSEACGGGEQQRLVTCPEP 1550
L P KP H C Q C L W S+W +CS C G Q+R + C E
Sbjct: 1022 AQLLPDAVCTSEPKPRMHEACLLQRCHKPKKLQWLVSAWSQCSVTCERGTQKRFLKCAEK 1081
Query: 1551 GL-----------CEEALRPNTT--RPCNTHPCTQ-------------WVVGPWGQCSGP 1584
+ C +P+ R C PC + W PW QC+
Sbjct: 1082 YVSGKYRELASKKCSHLPKPSLELERACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTAS 1141
Query: 1585 CGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPCGTEDCEPVEPPRCERDRLSFG 1644
CGGGVQ R V+C+ G P + C P +S C T C P+ + + F
Sbjct: 1142 CGGGVQTRSVQCL--AGGRP---ASGCLLHQKPSASLACNTHFC-PIAEKKDAFCKDYFH 1195
Query: 1645 FCETLRLLGRCQLPTIRTQCCRSCS 1669
+C + G C QCC++CS
Sbjct: 1196 WCYLVPQHGMCSHKFYGKQCCKTCS 1220
Score = 113 bits (283), Expect = 1e-24
Identities = 89/267 (33%), Positives = 108/267 (40%), Gaps = 42/267 (15%)
Query: 1400 EAGPPADPLVVRNAGWQAGNWSECSTTCGLGAVWRPVRCSSGRD-------EDCAPAGRP 1452
E PPA P W SECS +CG G + VR RD C P RP
Sbjct: 863 EKQPPAQPSYT----WAIVR-SECSVSCGGGQM--TVREGCYRDLKFQVNMSFCNPKTRP 915
Query: 1453 QPAR-RCHLRPCA-TWHSGNWSKCSRSCGGGSSVRDVQCVDT--RDLRPLRPFHCQPGPA 1508
C + C +W GNWS CSR+CGGG+ R VQC D P+ C P PA
Sbjct: 916 VTGLVPCKVSACPPSWSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLC-PQPA 974
Query: 1509 KPPAHRPCGAQPC-LSWYTSSWRECSEACGGGEQQRLVTCPE-----------PGLCEEA 1556
P + + C +Q C +W W ECS CG G ++R V C +C
Sbjct: 975 -PSSRQACNSQSCPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSE 1033
Query: 1557 LRPNTTRPCNTHPC-----TQWVVGPWGQCSGPCGGGVQRRLVKCVNTQTG--LPEEDSD 1609
+P C C QW+V W QCS C G Q+R +KC E S
Sbjct: 1034 PKPRMHEACLLQRCHKPKKLQWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASK 1093
Query: 1610 QCGHEAWP--ESSRPCGTEDCEPVEPP 1634
+C H P E R C C P PP
Sbjct: 1094 KCSHLPKPSLELERACAPLPC-PRHPP 1119
Score = 102 bits (255), Expect = 2e-21
Identities = 63/157 (40%), Positives = 77/157 (49%), Gaps = 13/157 (8%)
Query: 820 PPVFSWHYGPWTKCTVTCGRGVQRQNVYCLER---QAGPVDEEHCDPLGRPDDQQRKCSE 876
PP SW G W+ C+ TCG G Q + V C R + PV C P P +Q C+
Sbjct: 928 PP--SWSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLC-PQPAPSSRQA-CNS 983
Query: 877 QPCPARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPA-CEHLPRPPTETP 935
Q CP W AG W CS +CG G +RAV C +S ++ L P A C P+P
Sbjct: 984 QSCPPAWSAGPWAECSHTCGKGW-RKRAVAC-KSTNPSARAQLLPDAVCTSEPKPRMHEA 1041
Query: 936 C---NRHVPCPATWAVGNWSQCSVTCGEGTQRRNVLC 969
C H P W V WSQCSVTC GTQ+R + C
Sbjct: 1042 CLLQRCHKPKKLQWLVSAWSQCSVTCERGTQKRFLKC 1078
Score = 89.7 bits (221), Expect = 2e-17
Identities = 60/209 (28%), Positives = 91/209 (43%), Gaps = 30/209 (14%)
Query: 810 REAGGHDEVPPPVFSWHYGPWTKCTVTCGRGVQRQNVYCLER----QAGPVDEEHCDPLG 865
R+A PP +W GPW +C+ TCG+G +++ V C +A + + C
Sbjct: 978 RQACNSQSCPP---AWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEP 1034
Query: 866 RPDDQQ----RKCSEQPCPARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEP 921
+P + ++C +P +W W CS +C G +R + C + L
Sbjct: 1035 KPRMHEACLLQRC-HKPKKLQWLVSAWSQCSVTC-ERGTQKRFLKCAEKYVSGKYRELAS 1092
Query: 922 PACEHLPRPPTET-------PCNRHVPCPA------TWAVGNWSQCSVTCGEGTQRRNVL 968
C HLP+P E PC RH P A +W WSQC+ +CG G Q R+V
Sbjct: 1093 KKCSHLPKPSLELERACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQ 1152
Query: 969 CTNDTGVP---CDEAQQPASEVTCSLPLC 994
C G P C Q+P++ + C+ C
Sbjct: 1153 CLAG-GRPASGCLLHQKPSASLACNTHFC 1180
Score = 83.6 bits (205), Expect = 2e-15
Identities = 71/253 (28%), Positives = 92/253 (36%), Gaps = 55/253 (21%)
Query: 1355 GPKGQPESLSPEVPLSSRLLSTPAWDSPANSHRVPETQPLAPSLAEAGPPADPLVVRNAG 1414
G + +P + V S + PA S R P AGP
Sbjct: 946 GAQSRPVQCTRRVHYDSEPVPASLCPQPAPSSRQACNSQSCPPAWSAGP----------- 994
Query: 1415 WQAGNWSECSTTCGLGAVWRPVRCSSGRDE-------DCAPAGRPQP-------ARRCHL 1460
W+ECS TCG G R V C S D P+P +RCH
Sbjct: 995 -----WAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQRCHK 1049
Query: 1461 RPCATWHSGNWSKCSRSCGGGSSVRDVQCVD---TRDLRPLRPFHCQPGPAKP--PAHRP 1515
W WS+CS +C G+ R ++C + + R L C P KP R
Sbjct: 1050 PKKLQWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLP-KPSLELERA 1108
Query: 1516 CGAQPCL-------------SWYTSSWRECSEACGGGEQQRLVTC-----PEPGLCEEAL 1557
C PC SW+ S W +C+ +CGGG Q R V C P G C
Sbjct: 1109 CAPLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQCLAGGRPASG-CLLHQ 1167
Query: 1558 RPNTTRPCNTHPC 1570
+P+ + CNTH C
Sbjct: 1168 KPSASLACNTHFC 1180
Score = 37.7 bits (86), Expect = 0.095
Identities = 21/50 (42%), Positives = 26/50 (52%), Gaps = 8/50 (16%)
Query: 1527 SSWRECSEACGGG--EQQRLVTCPEPG----LCEEALRPNTTRPCNTHPC 1570
SSW CS CGGG + RL T P+P CE + R T + CN+ C
Sbjct: 593 SSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTR--TLKLCNSQKC 640
Score = 33.5 bits (75), Expect = 1.8
Identities = 19/55 (34%), Positives = 22/55 (40%), Gaps = 1/55 (1%)
Query: 539 GGWSGWSAWSICSRSCGMGVQSAERQCTQPTPKYKGRYCVGERKRFRLCNLQACP 593
G W S WS C+ SCG GVQ+ QC G + CN CP
Sbjct: 1128 GSWFA-SPWSQCTASCGGGVQTRSVQCLAGGRPASGCLLHQKPSASLACNTHFCP 1181
Score = 32.0 bits (71), Expect = 5.2
Identities = 12/24 (50%), Positives = 16/24 (66%)
Query: 1470 NWSKCSRSCGGGSSVRDVQCVDTR 1493
+WS CSR+CGGG S R C + +
Sbjct: 594 SWSPCSRTCGGGVSHRSRLCTNPK 617
>gi|112789555 ADAM metallopeptidase with thrombospondin type 1 motif,
19 preproprotein [Homo sapiens]
Length = 1207
Score = 584 bits (1505), Expect = e-166
Identities = 349/920 (37%), Positives = 482/920 (52%), Gaps = 65/920 (7%)
Query: 89 RELRFNLTANQHLLAPGFVSETRRRGGLGR--AHIRAHTPA-----CHLLGEVQDPELEG 141
R+L L + LAP F E R G G A PA C G V G
Sbjct: 174 RDLYLLLRRDGRFLAPRFAVEQRPNPGPGPTGAASAPQPPAPPDAGCFYTGAVL--RHPG 231
Query: 142 GLAAISACDG-LKGVFQLSNEDYFIEPLDSAPARPGHAQPHVVY--KRQAPERLAQRGDS 198
LA+ S C G L G QL+ + FIEPL+ A GH PH VY KR E++ ++
Sbjct: 232 SLASFSTCGGGLMGFIQLNEDFIFIEPLNDTMAITGH--PHRVYRQKRSMEEKVTEKSAL 289
Query: 199 SAPSTCGVQVYPELESRRERWEQRQQWRRPRLRRLHQRSVSKEKWVETLVVADAKMVEYH 258
+ CG+ S + R R+ R +R + + +E +ET+VVAD MV YH
Sbjct: 290 HS-HYCGII------SDKGRPRSRKIAESGRGKR-YSYKLPQEYNIETVVVADPAMVSYH 341
Query: 259 GQPQVESYVLTIMNMVAGLFHDPSIGNPIHITIVRLVLLEDEEEDLKITHHADNTLKSFC 318
G ++LTI+NMV LF S+ +++ +++L+LL + +L I HH + L+SFC
Sbjct: 342 GADAARRFILTILNMVFNLFQHKSLSVQVNLRVIKLILLHETPPELYIGHHGEKMLESFC 401
Query: 319 KWQ-KSINMKGDAH----------PLHHDTAILLTRKDLCAAMNRPCETLGLSHVAGMCQ 367
KWQ + K D H D AIL+TRKD C + PC+T+G+++++GMC
Sbjct: 402 KWQHEEFGKKNDIHLEMSTNWGEDMTSVDAAILITRKDFCVHKDEPCDTVGIAYLSGMCS 461
Query: 368 PHRSCSINEDTGLPLAFTVAHELGHSFGIQHDGSGNDCEPVGKRPFIMSPQLL--YDAAP 425
R C I ED GL LAFT+AHE+GH+ GI HD ND IMS + + +
Sbjct: 462 EKRKCIIAEDNGLNLAFTIAHEMGHNMGINHD---NDHPSCADGLHIMSGEWIKGQNLGD 518
Query: 426 LTWSRCSRQYITRFLDRGWGLCL--DDPPAKDIIDFPSVPPGVLYDVSHQCRLQYGAYSA 483
++WSRCS++ + RFL CL +P + + + PS PG+ Y QC++ +G ++
Sbjct: 519 VSWSRCSKEDLERFLRSKASNCLLQTNPQSVNSVMVPSKLPGMTYTADEQCQILFGPLAS 578
Query: 484 FCEDMDNV-CHTLWCSVG--TTCHSKLDAAVDGTRCGENKWCLSGECVPVGFRPEAVDGG 540
FC++M +V C LWC V C +KLD +DGT C KWC +GEC PE + G
Sbjct: 579 FCQEMQHVICTGLWCKVEGEKECRTKLDPPMDGTDCDLGKWCKAGECTSRTSAPEHLAGE 638
Query: 541 WSGWSAWSICSRSCGMGVQSAERQCTQPTPKYKGRYCVGERKRFRLCNLQACPAGRPSFR 600
WS WS CSR+C G+ S ER+C P + R C G RK++R+C CPAG P FR
Sbjct: 639 WS---LWSPCSRTCSAGISSRERKC--PGLDSEARDCNGPRKQYRICENPPCPAGLPGFR 693
Query: 601 HVQCSHFDAMLYKGQ-LHTWVPVVNDVNPCELHCRPANEYFAEKLRDAVVDGTPC-YQVR 658
QC + + + W V+++ PC L C P + L + V+DGT C YQ
Sbjct: 694 DWQCQAYSVRTSSPKHILQWQAVLDEEKPCALFCSPVGKEQPILLSEKVMDGTSCGYQ-- 751
Query: 659 ASRDLCINGICKNVGCDFEIDSGAMEDRCGVCHGNGSTCHTVSGTFEEAEGLGYVDVGLI 718
D+C NG C+ VGCD + S A ED CGVC+GNG +C + G F G GYV+V +I
Sbjct: 752 -GLDICANGRCQKVGCDGLLGSLAREDHCGVCNGNGKSCKIIKGDFNHTRGAGYVEVLVI 810
Query: 719 PAGAREIRIQEVAEAANFLALRSEDPEKYFLNGGWTIQWNGDYQVAGTTFTYARRGNWEN 778
PAGAR I++ E A ++LALR D K +N W I+ +G + +AGTT Y RRG WE
Sbjct: 811 PAGARRIKVVEEKPAHSYLALR--DAGKQSINSDWKIEHSGAFNLAGTTVHYVRRGLWEK 868
Query: 779 LTSPGPTKEPV-WIQLLFQESNPGVHYEYTIHRE---AGGHDEVPPPVFSWHYGPWTKCT 834
+++ GPT P+ + LLFQ+ N G+HYEYTI + + P P+F W + W C
Sbjct: 869 ISAKGPTTAPLHLLVLLFQDQNYGLHYEYTIPSDPLPENQSSKAPEPLFMWTHTSWEDCD 928
Query: 835 VTCGRGVQRQNVYC---LERQAGPVDEEHCDPLGRPDDQQRKCSEQPCPARWWAGEWQLC 891
TCG G ++ V C + + VD E C L +P+ Q RKC+EQPC RW EW C
Sbjct: 929 ATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNEQPCQTRWMMTEWTPC 988
Query: 892 SSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPCNRHVPCPATWAVGNW 951
S +CG G+ R V C + + C P+P + C C W G W
Sbjct: 989 SRTCGK-GMQSRQVACTQQLSNGTLIRARERDCIG-PKPASAQRCEGQ-DCMTVWEAGVW 1045
Query: 952 SQCSVTCGEGTQRRNVLCTN 971
S+CSV CG+G + R V CTN
Sbjct: 1046 SECSVKCGKGIRHRTVRCTN 1065
Score = 131 bits (329), Expect = 6e-30
Identities = 91/302 (30%), Positives = 129/302 (42%), Gaps = 43/302 (14%)
Query: 1404 PADPLVVRNAG--------WQAGNWSECSTTCGLGAVWRPVRC--------SSGRDEDCA 1447
P+DPL + W +W +C TCG G V C S +E C
Sbjct: 900 PSDPLPENQSSKAPEPLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCK 959
Query: 1448 PAGRPQPA-RRCHLRPCAT-WHSGNWSKCSRSCGGGSSVRDVQC---VDTRDLRPLRPFH 1502
+P+P R+C+ +PC T W W+ CSR+CG G R V C + L R
Sbjct: 960 YLTKPEPQIRKCNEQPCQTRWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERD 1019
Query: 1503 CQPGPAKPPAHRPCGAQPCLS-WYTSSWRECSEACGGGEQQRLVTCPEPGL-CEEALRPN 1560
C GP KP + + C Q C++ W W ECS CG G + R V C P C + RP
Sbjct: 1020 CI-GP-KPASAQRCEGQDCMTVWEAGVWSECSVKCGKGIRHRTVRCTNPRKKCVLSTRPR 1077
Query: 1561 TTRPCNTHP-CTQWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPES 1619
C + C W +G W +CS CG G+Q R+++C++ TG ++C P +
Sbjct: 1078 EAEDCEDYSKCYVWRMGDWSKCSITCGKGMQSRVIQCMHKITG---RHGNECFSSEKPAA 1134
Query: 1620 SRPCGTEDC------EPVEPPR-------CERDRLSFGFCETLRLLGRCQLPTIRTQCCR 1666
RPC + C + PR C D+ +C +R CQ +CC
Sbjct: 1135 YRPCHLQPCNEKINVNTITSPRLAALTFKCLGDQWPV-YCRVIREKNLCQDMRWYQRCCE 1193
Query: 1667 SC 1668
+C
Sbjct: 1194 TC 1195
Score = 45.4 bits (106), Expect = 5e-04
Identities = 20/57 (35%), Positives = 31/57 (54%), Gaps = 2/57 (3%)
Query: 823 FSWHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQPC 879
+ W G W+KC++TCG+G+Q + + C+ + G E C +P R C QPC
Sbjct: 1089 YVWRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNE-CFSSEKP-AAYRPCHLQPC 1143
Score = 41.6 bits (96), Expect = 0.007
Identities = 29/110 (26%), Positives = 47/110 (42%), Gaps = 12/110 (10%)
Query: 547 WSICSRSCGMGVQSAERQCTQPTPKYKGRYCVGERK--RFRLCNLQACPAGRPSFRHVQC 604
WS CS +CG G+QS QC G C K +R C+LQ C + + +
Sbjct: 1096 WSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRPCHLQPCNE-KINVNTITS 1154
Query: 605 SHFDAMLYK---GQLHTWVPVVNDVNPC------ELHCRPANEYFAEKLR 645
A+ +K Q + V+ + N C + C +++A+KL+
Sbjct: 1155 PRLAALTFKCLGDQWPVYCRVIREKNLCQDMRWYQRCCETCRDFYAQKLQ 1204
Score = 32.0 bits (71), Expect = 5.2
Identities = 23/70 (32%), Positives = 30/70 (42%), Gaps = 10/70 (14%)
Query: 1197 PVGKDSQSQL--PPPWRDRTNEVFKDDEEPKGR--------GAPHLPPRPSSTLPPLSPV 1246
PV S+S+L PPP +E + E P+G GAP P PP SP
Sbjct: 94 PVEGRSESRLRPPPPSEGEEDEELESQELPRGSSGAAALSPGAPASWQPPPPPQPPPSPP 153
Query: 1247 GSTHSSPSPD 1256
+ H+ P D
Sbjct: 154 PAQHAEPDGD 163
>gi|110611170 ADAM metallopeptidase with thrombospondin type 1
motif, 17 preproprotein [Homo sapiens]
Length = 1095
Score = 579 bits (1492), Expect = e-165
Identities = 365/1027 (35%), Positives = 501/1027 (48%), Gaps = 117/1027 (11%)
Query: 12 PLLRPLLLLLCALAPGAPGPAPGRATEGRAA-LDIVHPVRVDAGGSFLS-YELWPRALRK 69
PL+ P+LLLL G PG A AA +++V P RV L P R+
Sbjct: 9 PLVLPVLLLLVW------GLDPGTAVGDAAADVEVVLPWRVRPDDVHLPPLPAAPGPRRR 62
Query: 70 RDVSVRRDAPA--------FYELQYRGRELRFNLTANQHLLAPGFVSE----TRRRGGLG 117
R AP L GR+L L + L+ GF E RRRG
Sbjct: 63 RRPRTPPAAPRARPGERALLLHLPAFGRDLYLQLRRDLRFLSRGFEVEEAGAARRRG--- 119
Query: 118 RAHIRAHTPA--CHLLGEVQDPELEGGLAAISACD---GLKGVFQLSNEDYFIEPLDSAP 172
PA C G V G L ++SAC GL G+ QL E I+PL+++
Sbjct: 120 -------RPAELCFYSGRVLGHP--GSLVSLSACGAAGGLVGLIQLGQEQVLIQPLNNSQ 170
Query: 173 ARPGHAQPHVVYKRQAPERLAQRGDSSAPSTCGVQVYPELESRRERWEQRQQWRRPRLRR 232
P + H++ ++ S PS PE + +++ W RP
Sbjct: 171 G-PFSGREHLIRRKW----------SLTPSPSAEAQRPEQLCKVLTEKKKPTWGRPSRDW 219
Query: 233 LHQRS---VSKEKWVETLVVADAKMVEYHGQPQVESYVLTIMNMVAGLFHDPSIGNPIHI 289
+R+ ++ E VETLVVADA MV+YHG + ++LT+MNMV +F S+G I+I
Sbjct: 220 RERRNAIRLTSEHTVETLVVADADMVQYHGAEAAQRFILTVMNMVYNMFQHQSLGIKINI 279
Query: 290 TIVRLVLLEDEEEDLKITHHADNTLKSFCKWQKSIN-----------MKGDAHPLHHDTA 338
+ +LVLL L I HH + +L+SFC WQ G P D A
Sbjct: 280 QVTKLVLLRQRPAKLSIGHHGERSLESFCHWQNEEYGGARYLGNNQVPGGKDDPPLVDAA 339
Query: 339 ILLTRKDLCAAMNRPCETLGLSHVAGMCQPHRSCSINEDTGLPLAFTVAHELGHSFGIQH 398
+ +TR D C + PC+T+G++++ G+C R C + ED GL LAFT+AHELGH+ G+ H
Sbjct: 340 VFVTRTDFCVHKDEPCDTVGIAYLGGVCSAKRKCVLAEDNGLNLAFTIAHELGHNLGMNH 399
Query: 399 DGSGNDCEPVGKRPFIMSPQLLYDAAP--LTWSRCSRQYITRFLDRGWGLCL--DDPPAK 454
D + C R IMS + + P L+WS CSR + FL CL DP ++
Sbjct: 400 DDDHSSC---AGRSHIMSGEWVKGRNPSDLSWSSCSRDDLENFLKSKVSTCLLVTDPRSQ 456
Query: 455 DIIDFPSVPPGVLYDVSHQCRLQYGAYSAFCEDMDNV-CHTLWCSV--GTTCHSKLDAAV 511
+ P PG+ Y + QC++ +G + FC +M+++ C LWC V T+C +KLD +
Sbjct: 457 HTVRLPHKLPGMHYSANEQCQILFGMNATFCRNMEHLMCAGLWCLVEGDTSCKTKLDPPL 516
Query: 512 DGTRCGENKWCLSGECVPVGFRPEAVDGGWSGWSAWSICSRSCGMGVQSAERQCTQPTPK 571
DGT CG +KWC +GECV PE VDG WS W AWS+CSR+CG G + +R+C P P
Sbjct: 517 DGTECGADKWCRAGECVSKTPIPEHVDGDWSPWGAWSMCSRTCGTGARFRQRKCDNPPPG 576
Query: 572 YKGRYCVGERKRFRLCNLQACPAGRPSFRHVQCSHFDAMLYKGQLHTWVPVVNDVNPCEL 631
G +C G +C CP G PSFR QC D + K + VV+D PCEL
Sbjct: 577 PGGTHCPGASVEHAVCENLPCPKGLPSFRDQQCQAHDRLSPKKKGLLTAVVVDD-KPCEL 635
Query: 632 HCRPANEYFAEKLRDAVVDGTPCYQVRASRDLCINGICKNVGCDFEIDSGAMEDRCGVCH 691
+C P + + D V+DGTPC DLC++G C+ +GCD I S A EDRCGVC
Sbjct: 636 YCSPLGKESPLLVADRVLDGTPCGPYET--DLCVHGKCQKIGCDGIIGSAAKEDRCGVCS 693
Query: 692 GNGSTCHTVSGTFEEAEGLGYVDVGLIPAGAREIRIQEVAEAANFLALRSEDPEKYFLNG 751
G+G TCH V G F A G D G K +N
Sbjct: 694 GDGKTCHLVKGDFSHARGTALKDSG-----------------------------KGSINS 724
Query: 752 GWTIQWNGDYQVAGTTFTYARRGNWENLTSPGPTKEPVWIQ-LLFQESNPGVHYEYT--I 808
W I+ G++Q+AGTT Y RRG WE +++ GPTK P+ + LLF + + G+HYEYT +
Sbjct: 725 DWKIELPGEFQIAGTTVRYVRRGLWEKISAKGPTKLPLHLMVLLFHDQDYGIHYEYTVPV 784
Query: 809 HREAGGHDEVPPP---VFSWHYGPWTKCTVTCGRGVQRQNVYC---LERQAGPVDEEHCD 862
+R A E P +F W + W C+V CG G +R V C + + V++ C
Sbjct: 785 NRTAENQSEPEKPQDSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCP 844
Query: 863 PLGRPDDQQRKCSEQPCPARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPP 922
RP+ Q R+C+ PC +RW AG W CS++C G R V C+ + A P
Sbjct: 845 QASRPEPQVRRCNLHPCQSRWVAGPWSPCSATC-EKGFQHREVTCVYQLQNGTHVATRPL 903
Query: 923 ACEHLPRPPTETPCNRHVPCPATWAVGNWSQCSVTCGEGTQRRNVLCTNDTGVPCDEAQQ 982
C PRP C C + W WSQCS +CG+G +R V CTN G CD + +
Sbjct: 904 YCPG-PRPAAVQSCEGQ-DCLSIWEASEWSQCSASCGKGVWKRTVACTNSQG-KCDASTR 960
Query: 983 PASEVTC 989
P +E C
Sbjct: 961 PRAEEAC 967
Score = 155 bits (392), Expect = 3e-37
Identities = 101/303 (33%), Positives = 136/303 (44%), Gaps = 39/303 (12%)
Query: 1395 APSLAEAGPPADPLVVRNAGWQAGNWSECSTTCGLGAVWRPVRCSS--------GRDEDC 1446
A + +E P D L + W W CS CG G V C+ D DC
Sbjct: 788 AENQSEPEKPQDSLFI----WTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDC 843
Query: 1447 APAGRPQP-ARRCHLRPCAT-WHSGNWSKCSRSCGGGSSVRDVQCV---DTRDLRPLRPF 1501
A RP+P RRC+L PC + W +G WS CS +C G R+V CV RP
Sbjct: 844 PQASRPEPQVRRCNLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPL 903
Query: 1502 HCQPGPAKPPAHRPCGAQPCLS-WYTSSWRECSEACGGGEQQRLVTCPEP-GLCEEALRP 1559
+C PGP +P A + C Q CLS W S W +CS +CG G +R V C G C+ + RP
Sbjct: 904 YC-PGP-RPAAVQSCEGQDCLSIWEASEWSQCSASCGKGVWKRTVACTNSQGKCDASTRP 961
Query: 1560 NTTRPCNTHP-CTQWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPE 1618
C + C +W G W CS CG G+Q R+V+C++ TG +C + P
Sbjct: 962 RAEEACEDYSGCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTG---RHGSECPALSKPA 1018
Query: 1619 SSRPCGTEDC------EPVEPPR-------CERDRLSFGFCETLRLLGRCQLPTIRTQCC 1665
R C E C + PR C RD+ + +C +R CQ +CC
Sbjct: 1019 PYRQCYQEVCNDRINANTITSPRLAALTYKCTRDQWTV-YCRVIREKNLCQDMRWYQRCC 1077
Query: 1666 RSC 1668
++C
Sbjct: 1078 QTC 1080
Score = 43.9 bits (102), Expect = 0.001
Identities = 20/60 (33%), Positives = 32/60 (53%), Gaps = 2/60 (3%)
Query: 823 FSWHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQPCPAR 882
+ W G W+ C+ TCG+G+Q + V C+ + G E C L +P R+C ++ C R
Sbjct: 974 YEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSE-CPALSKP-APYRQCYQEVCNDR 1031
Score = 43.1 bits (100), Expect = 0.002
Identities = 44/186 (23%), Positives = 68/186 (36%), Gaps = 37/186 (19%)
Query: 485 CEDMDNVCHTLW-CSVGTTCHSKLDAAVDGTRCGENKWCLSGECV------PVGFRPEAV 537
CE D C ++W S + C + CG+ W + C RP A
Sbjct: 916 CEGQD--CLSIWEASEWSQCSAS---------CGKGVWKRTVACTNSQGKCDASTRPRAE 964
Query: 538 DG-----GWSGWSA--WSICSRSCGMGVQSAERQCTQPTPKYKGRYC--VGERKRFRLCN 588
+ G W WS CS +CG G+QS QC G C + + +R C
Sbjct: 965 EACEDYSGCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQCY 1024
Query: 589 LQACPAGRPSFRHVQCSHFDAMLYKGQLHTWV---PVVNDVNPC------ELHCRPANEY 639
+ C R + + A+ YK W V+ + N C + C+ ++
Sbjct: 1025 QEVC-NDRINANTITSPRLAALTYKCTRDQWTVYCRVIREKNLCQDMRWYQRCCQTCRDF 1083
Query: 640 FAEKLR 645
+A K+R
Sbjct: 1084 YANKMR 1089
Score = 33.9 bits (76), Expect = 1.4
Identities = 21/55 (38%), Positives = 24/55 (43%), Gaps = 9/55 (16%)
Query: 1469 GNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRP--FHCQPGPAKPPAHRPCGAQPC 1521
G WS CSR+CG G+ R +C D P P HC P H C PC
Sbjct: 550 GAWSMCSRTCGTGARFRQRKC----DNPPPGPGGTHC---PGASVEHAVCENLPC 597
Score = 33.5 bits (75), Expect = 1.8
Identities = 35/123 (28%), Positives = 44/123 (35%), Gaps = 18/123 (14%)
Query: 542 SGWSA--WSICSRSCGMGVQSAERQCTQPTPK-----YKGRYCVGER-KRFRLCNLQACP 593
S W A WS CS +C G Q E C + YC G R + C Q C
Sbjct: 863 SRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQSCEGQDCL 922
Query: 594 AGRPSFRHVQCSHFDAMLYKGQLHTWVPVVNDVNPCELHCRPANEYFAEKLRDAVVDGTP 653
+ + QCS A KG V N C+ RP E +A D +
Sbjct: 923 SIWEASEWSQCS---ASCGKGVWKRTVACTNSQGKCDASTRPRAE-------EACEDYSG 972
Query: 654 CYQ 656
CY+
Sbjct: 973 CYE 975
Score = 31.2 bits (69), Expect = 8.9
Identities = 12/23 (52%), Positives = 15/23 (65%)
Query: 1418 GNWSECSTTCGLGAVWRPVRCSS 1440
G WS CS TCG GA +R +C +
Sbjct: 550 GAWSMCSRTCGTGARFRQRKCDN 572
>gi|33624896 ADAM metallopeptidase with thrombospondin type 1 motif, 9
preproprotein [Homo sapiens]
Length = 1935
Score = 554 bits (1427), Expect = e-157
Identities = 369/1110 (33%), Positives = 532/1110 (47%), Gaps = 166/1110 (14%)
Query: 31 PAPGRATEGRAALDIVHPVRVDAGGSFLSYELWPRALRKRDVSVRRDAPAF--------- 81
P + E + +IV P+RV+A G + + R+ S PAF
Sbjct: 36 PRQVKLLETLSEYEIVSPIRVNALGEPFPTNVHFKRTRRSINSATDPWPAFASSSSSSTS 95
Query: 82 ----YELQYRGRELRFNLTANQHLLAPGFVSETRRRGGLGRAHIRAHTPA----CHLLGE 133
Y L G++ FNLTAN +AP F G+ + + A C G
Sbjct: 96 SQAHYRLSAFGQQFLFNLTANAGFIAPLFTVTLLGTPGVNQTKFYSEEEAELKHCFYKGY 155
Query: 134 VQDPELEGGLAAISACDGLKGVFQLSNEDYFIEPLDSAPARPGHAQ---PHVVYKRQAPE 190
V A IS C G+ G F+ + DYFIEPL S + + PH++Y+R AP
Sbjct: 156 VNTNSEH--TAVISLCSGMLGTFRSHDGDYFIEPLQSMDEQEDEEEQNKPHIIYRRSAP- 212
Query: 191 RLAQRGDSSAPSTCGVQVYPELESRRERWEQRQQW------------------------- 225
QR S+ C + S+ ++ + ++W
Sbjct: 213 ---QREPSTGRHACDTSEHKNRHSKDKKKTRARKWGERINLAGDVAALNSGLATEAFSAY 269
Query: 226 -------RRPRLRRLHQRSVSKEKWVETLVVADAKMVEYHGQPQVESYVLTIMNMVAGLF 278
R R R +R +S ++VE LVVAD +MV YHG+ ++ Y+LT+M++VA ++
Sbjct: 270 GNKTDNTREKRTHRRTKRFLSYPRFVEVLVVADNRMVSYHGE-NLQHYILTLMSIVASIY 328
Query: 279 HDPSIGNPIHITIVRLVLLEDEEEDLKITHHADNTLKSFCKWQKSINMKGDAHPLHHDTA 338
DPSIGN I+I IV L+++ +E++ I+ +A TLK+FC+WQ S N G +HHDTA
Sbjct: 329 KDPSIGNLINIVIVNLIVIHNEQDGPSISFNAQTTLKNFCQWQHSKNSPGG---IHHDTA 385
Query: 339 ILLTRKDLCAAMNRPCETLGLSHVAGMCQPHRSCSINEDTGLPLAFTVAHELGHSFGIQH 398
+LLTR+D+C A ++ C+TLGL+ + +C P+RSCSI+ED+GL AFT+AHELGH F + H
Sbjct: 386 VLLTRQDICRAHDK-CDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVFNMPH 444
Query: 399 DGSGNDCEPVG-KRP-FIMSPQLLYDAAPLTWSRCSRQYITRFLDRGWGLCLDDPPAKDI 456
D + N C+ G K P +M+P L + P WS+CSR+YIT FLD G+G CL + P
Sbjct: 445 DDN-NKCKEEGVKSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGECLLNEPESRP 503
Query: 457 IDFPSVPPGVLYDVSHQCRLQYGAYSAFCEDMDNVCHTLWCS----VGTTCHSKLDAAVD 512
P PG+LY+V+ QC L +G S C M C LWC+ V C ++ D
Sbjct: 504 YPLPVQLPGILYNVNKQCELIFGPGSQVCPYMMQ-CRRLWCNNVNGVHKGCRTQHTPWAD 562
Query: 513 GTRCGENKWCLSGECVPVGFRPEAVDGGWSGWSAWSICSRSCGMGVQSAERQCTQPTPKY 572
GT C K C G CVP DG W WS + CSR+CG G+++A R+C +P PK
Sbjct: 563 GTECEPGKHCKYGFCVPKEMDVPVTDGSWGSWSPFGTCSRTCGGGIKTAIRECNRPEPKN 622
Query: 573 KGRYCVGERKRFRLCNLQACPAGRPSFRHVQCSHFDAMLY--KGQLHT--WVPVVNDV-- 626
G+YCVG R +F+ CN + C + FR QC+HFD + G L WVP + +
Sbjct: 623 GGKYCVGRRMKFKSCNTEPCLKQKRDFRDEQCAHFDGKHFNINGLLPNVRWVPKYSGILM 682
Query: 627 -NPCELHCRPANEYFAEKLRDAVVDGTPCYQVRASRDLCINGICKNVGCDFEIDSGAMED 685
+ C+L CR A +LRD V+DGTPC Q + D+C+ G+C+ GCD ++S A D
Sbjct: 683 KDRCKLFCRVAGNTAYYQLRDRVIDGTPCGQ--DTNDICVQGLCRQAGCDHVLNSKARRD 740
Query: 686 RCGVCHGNGSTCHTVSGTFEEAEGLGYVDVGLIPAGAREIRIQE-----VAEAANFLALR 740
+CGVC G+ S+C TV+GTF GY V IPAGA I +++ + N+LAL
Sbjct: 741 KCGVCGGDNSSCKTVAGTFNTVH-YGYNTVVRIPAGATNIDVRQHSFSGETDDDNYLALS 799
Query: 741 SEDPEKYFLNGGWTIQW-NGDYQVAGTTFTYA-RRGNWENLTSPGPTKEPVWIQLLF--Q 796
S E + LNG + + + ++ Y+ E + S ++ + +Q+L +
Sbjct: 800 SSKGE-FLLNGNFVVTMAKREIRIGNAVVEYSGSETAVERINSTDRIEQELLLQVLSVGK 858
Query: 797 ESNPGVHYEYTIHREA-------GGH---------------------------------- 815
NP V Y + I E H
Sbjct: 859 LYNPDVRYSFNIPIEDKPQQFYWNSHGPWQACSKPCQGERKRKLVCTRESDQLTVSDQRC 918
Query: 816 DEVPPP-----------VFSWHYGPWTKCTVTCGRGVQRQNVYC-----LERQAGPVDEE 859
D +P P WH ++C+ CG G + ++YC L+ + VD+
Sbjct: 919 DRLPQPGHITEPCGTDCDLRWHVASRSECSAQCGLGYRTLDIYCAKYSRLDGKTEKVDDG 978
Query: 860 HCDPLGRPDDQQRKCSEQPCPARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSAL 919
C +P +++ KCS + W W CS SC GG RR +C+ + L
Sbjct: 979 FCSSHPKPSNRE-KCSGECNTGGWRYSAWTECSKSC-DGGTQRRRAICVNT----RNDVL 1032
Query: 920 EPPACEHLPRPPTETPCNRHVPCPATWAVGNWSQCSVTCGEGTQRRNVLC------TNDT 973
+ C H + T C+ PCP W G+WS+C VTCG+G + R V C ND
Sbjct: 1033 DDSKCTHQEK-VTIQRCS-EFPCP-QWKSGDWSECLVTCGKGHKHRQVWCQFGEDRLNDR 1089
Query: 974 GVPCDEAQQPASEVTCSLPLC-RWPLGTLG 1002
CD +P S TC P C W G G
Sbjct: 1090 --MCDPETKPTSMQTCQQPECASWQAGPWG 1117
Score = 141 bits (356), Expect = 5e-33
Identities = 81/247 (32%), Positives = 102/247 (41%), Gaps = 30/247 (12%)
Query: 1415 WQAGNWSECSTTCGLGAVWRPVRCSSGRDE----DCAPAGRPQPARRCHLRPCATWHSGN 1470
W++G+WSEC TCG G R V C G D C P +P + C CA+W +G
Sbjct: 1056 WKSGDWSECLVTCGKGHKHRQVWCQFGEDRLNDRMCDPETKPTSMQTCQQPECASWQAGP 1115
Query: 1471 WSKCSRSCGGGSSVRDVQC--------VDTRDLRPL-RPFH--------CQPGPAKPPAH 1513
W +CS +CG G +R V+C VD D RP C P PA P
Sbjct: 1116 WGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSCHPPPAAPETR 1175
Query: 1514 RPCGAQPCLSWYTSSWRECSEACGGGEQQRLVTC-------PEPGLCEEALRPNTTRPCN 1566
R + P W SW CS CG G + R V+C + C RP C+
Sbjct: 1176 RSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCRDENGSVADESACATLPRPVAKEECS 1235
Query: 1567 THPCTQWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPCGTE 1626
PC QW W CS CG G R V CVN + D +C + PE+ + C
Sbjct: 1236 VTPCGQWKALDWSSCSVTCGQGRATRQVMCVNYSDHV--IDRSECDQDYIPETDQDCSMS 1293
Query: 1627 DCEPVEP 1633
C P
Sbjct: 1294 PCPQRTP 1300
Score = 140 bits (354), Expect = 8e-33
Identities = 83/240 (34%), Positives = 111/240 (46%), Gaps = 31/240 (12%)
Query: 1415 WQAGNWSECSTTCGLGAVWRPVRCSSG-----RDEDCAPAGRPQPARRCHLRPCA--TWH 1467
W+AG WS+CS +CG G R V C G R+ +C P RP+ R C C TW
Sbjct: 1501 WKAGAWSQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQGPRCPLYTWR 1560
Query: 1468 SGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAHRPCGAQPC-LSWYT 1526
+ W +C+++CG GS R V CVD + C +P C QPC W T
Sbjct: 1561 AEEWQECTKTCGEGSRYRKVVCVDDNK-NEVHGARCDVSK-RPVDRESCSLQPCEYVWIT 1618
Query: 1527 SSWRECSEACGGGEQQRLVTCPEPGLCEE--------ALRPNTTRPCNTHPC-------- 1570
W ECS CG G +QRLV+C E +E + T+P + HPC
Sbjct: 1619 GEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPCYLRDCPVS 1678
Query: 1571 TQWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPC-GTEDCE 1629
W VG WG CS CG GV +R V+C+ + ++ S C + PE + C +CE
Sbjct: 1679 ATWRVGNWGSCSVSCGVGVMQRSVQCLTNE----DQPSHLCHTDLKPEERKTCRNVYNCE 1734
Score = 139 bits (350), Expect = 2e-32
Identities = 88/279 (31%), Positives = 118/279 (42%), Gaps = 64/279 (22%)
Query: 1403 PPADPLVVRNA------GWQAGNWSECSTTCGLGAVWRPVRCSSGRDED--------CAP 1448
PPA P R+ W+ G+W+ CS TCG G R V C RDE+ CA
Sbjct: 1168 PPAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSC---RDENGSVADESACAT 1224
Query: 1449 AGRPQPARRCHLRPCATWHSGNWSKCSRSCGGGSSVRDVQCVD-----------TRDLRP 1497
RP C + PC W + +WS CS +CG G + R V CV+ +D P
Sbjct: 1225 LPRPVAKEECSVTPCGQWKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDRSECDQDYIP 1284
Query: 1498 LRPFHCQ--PGPAKPPA------------HRPCGAQPCLS-------WYTSSWRECSEAC 1536
C P P + P +RP A P + W T W CS C
Sbjct: 1285 ETDQDCSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTC 1344
Query: 1537 GGGEQQRLVTCPEPGL-----CEEALRPNTTRPCNTHPCTQWVVGPWGQCSGPCGGGVQR 1591
GG Q+R+V C + C E ++P+ R C + PC QW G WG+C+ CGGG++
Sbjct: 1345 AGGSQRRVVVCQDENGYTANDCVERIKPDEQRACESGPCPQWAYGNWGECTKLCGGGIRT 1404
Query: 1592 RLVKCVNTQ-TGLPE---------EDSDQCGHEAWPESS 1620
RLV C + P+ D +QC A P +
Sbjct: 1405 RLVVCQRSNGERFPDLSCEILDKPPDREQCNTHACPHDA 1443
Score = 134 bits (338), Expect = 6e-31
Identities = 79/238 (33%), Positives = 100/238 (42%), Gaps = 17/238 (7%)
Query: 1404 PADPLVVRNAGWQAGNWSECSTTCGLGAVWRPVRCSSGRD---EDCAPAGRPQPARRCHL 1460
P+ V+ W+ G W CS+TC G+ R V C DC +P R C
Sbjct: 1321 PSRTHVLGGNQWRTGPWGACSSTCAGGSQRRVVVCQDENGYTANDCVERIKPDEQRACES 1380
Query: 1461 RPCATWHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAHRPCGAQP 1520
PC W GNW +C++ CGGG R V C + R C+ KPP C
Sbjct: 1381 GPCPQWAYGNWGECTKLCGGGIRTRLVVCQRSNGER-FPDLSCEILD-KPPDREQCNTHA 1438
Query: 1521 C---LSWYTSSWRECSEACGGGEQQRLVTCP-------EPGLCEEALRPNTTRPCNTHPC 1570
C +W T W CS +CG G +QR V C E C+ +P+ R C C
Sbjct: 1439 CPHDAAWSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLESDYCKHLAKPHGHRKCRGGRC 1498
Query: 1571 TQWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPCGTEDC 1628
+W G W QCS CG GVQ+R V C + E +C PES R C C
Sbjct: 1499 PKWKAGAWSQCSVSCGRGVQQRHVGCQIGTHKIARE--TECNPYTRPESERDCQGPRC 1554
Score = 128 bits (322), Expect = 4e-29
Identities = 86/281 (30%), Positives = 102/281 (36%), Gaps = 71/281 (25%)
Query: 1413 AGWQAGNWSECSTTCGLGAVWRPVRCSSGR------DEDCAPAGRPQPARRCHLRPC--- 1463
A WQAG W +CS TCG G R V+C G D DC A RP + C L C
Sbjct: 1109 ASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSCHPP 1168
Query: 1464 ---------------ATWHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPA 1508
W G+W+ CS +CG G+ +R V C D C P
Sbjct: 1169 PAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCRDENG-SVADESACATLP- 1226
Query: 1509 KPPAHRPCGAQPCLSWYTSSWRECSEACGGGEQQRLVTC--------------------- 1547
+P A C PC W W CS CG G R V C
Sbjct: 1227 RPVAKEECSVTPCGQWKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDRSECDQDYIPET 1286
Query: 1548 -------------PEPGLCE-----EALRPNTTRPCNTHPC--TQWVVGPWGQCSGPCGG 1587
P+ GL + E RP + P TH QW GPWG CS C G
Sbjct: 1287 DQDCSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCAG 1346
Query: 1588 GVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPCGTEDC 1628
G QRR+V C + G D C P+ R C + C
Sbjct: 1347 GSQRRVVVC-QDENGYTAND---CVERIKPDEQRACESGPC 1383
Score = 124 bits (312), Expect = 6e-28
Identities = 63/179 (35%), Positives = 94/179 (52%), Gaps = 14/179 (7%)
Query: 824 SWHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQPCPARW 883
+W GPW+ C+V+CGRG +++NVYC+ + ++ ++C L +P RKC CP +W
Sbjct: 1444 AWSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLESDYCKHLAKPHG-HRKCRGGRCP-KW 1501
Query: 884 WAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPCNRHVPCP 943
AG W CS SCG G+ +R V C + C RP +E C + CP
Sbjct: 1502 KAGAWSQCSVSCG-RGVQQRHVGC----QIGTHKIARETECNPYTRPESERDC-QGPRCP 1555
Query: 944 A-TWAVGNWSQCSVTCGEGTQRRNVLCTNDT-----GVPCDEAQQPASEVTCSLPLCRW 996
TW W +C+ TCGEG++ R V+C +D G CD +++P +CSL C +
Sbjct: 1556 LYTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPCEY 1614
Score = 124 bits (311), Expect = 8e-28
Identities = 78/248 (31%), Positives = 105/248 (42%), Gaps = 29/248 (11%)
Query: 1415 WQAGNWSECSTTCGLGAVWRPVRCSS-----GRDED-----CAPAGRPQPARRCHLRPCA 1464
W + SECS CGLG + C+ G+ E C+ +P +C C
Sbjct: 939 WHVASRSECSAQCGLGYRTLDIYCAKYSRLDGKTEKVDDGFCSSHPKPSNREKCS-GECN 997
Query: 1465 T--WHSGNWSKCSRSCGGGSSVRDVQCVDTRD--LRPLRPFHCQPGPAKPPAHRPCGAQP 1520
T W W++CS+SC GG+ R CV+TR+ L + H + K R C P
Sbjct: 998 TGGWRYSAWTECSKSCDGGTQRRRAICVNTRNDVLDDSKCTHQE----KVTIQR-CSEFP 1052
Query: 1521 CLSWYTSSWRECSEACGGGEQQRLVTCP------EPGLCEEALRPNTTRPCNTHPCTQWV 1574
C W + W EC CG G + R V C +C+ +P + + C C W
Sbjct: 1053 CPQWKSGDWSECLVTCGKGHKHRQVWCQFGEDRLNDRMCDPETKPTSMQTCQQPECASWQ 1112
Query: 1575 VGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPCGTEDCEPVEPP 1634
GPWGQCS CG G Q R VKC+ T + D + C P ++ C C P PP
Sbjct: 1113 AGPWGQCSVTCGQGYQLRAVKCI-IGTYMSVVDDNDCNAATRPTDTQDCELPSCHP--PP 1169
Query: 1635 RCERDRLS 1642
R S
Sbjct: 1170 AAPETRRS 1177
Score = 116 bits (290), Expect = 2e-25
Identities = 73/245 (29%), Positives = 93/245 (37%), Gaps = 35/245 (14%)
Query: 1414 GWQAGNWSECSTTCGLGAVWRPVRCSSGR----DEDCAPAGRPQPARRCHLRPCATWHSG 1469
GW+ W+ECS +C G R C + R D+ +RC PC W SG
Sbjct: 1000 GWRYSAWTECSKSCDGGTQRRRAICVNTRNDVLDDSKCTHQEKVTIQRCSEFPCPQWKSG 1059
Query: 1470 NWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAHRPCGAQPCLSWYTSSW 1529
+WS+C +CG G R V C D L C P KP + + C C SW W
Sbjct: 1060 DWSECLVTCGKGHKHRQVWCQFGED--RLNDRMCDP-ETKPTSMQTCQQPECASWQAGPW 1116
Query: 1530 RECSEACGGGEQQRLVTC--------PEPGLCEEALRPNTTRPCNTHPC----------- 1570
+CS CG G Q R V C + C A RP T+ C C
Sbjct: 1117 GQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSCHPPPAAPETRR 1176
Query: 1571 -------TQWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPC 1623
TQW G W CS CG G + R V C + + +E + C P + C
Sbjct: 1177 STYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCRDENGSVADESA--CATLPRPVAKEEC 1234
Query: 1624 GTEDC 1628
C
Sbjct: 1235 SVTPC 1239
Score = 115 bits (287), Expect = 5e-25
Identities = 63/175 (36%), Positives = 83/175 (47%), Gaps = 8/175 (4%)
Query: 821 PVFSWHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQPCP 880
P+++W W +CT TCG G + + V C++ V CD RP D++ CS QPC
Sbjct: 1555 PLYTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRE-SCSLQPCE 1613
Query: 881 ARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLP--RPPTETPCN- 937
W GEW CS +CG G +R V C E + P +PP+ PC
Sbjct: 1614 YVWITGEWSECSVTCGKG-YKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPCYL 1672
Query: 938 RHVPCPATWAVGNWSQCSVTCGEGTQRRNVLCTNDTGVP---CDEAQQPASEVTC 989
R P ATW VGNW CSV+CG G +R+V C + P C +P TC
Sbjct: 1673 RDCPVSATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPSHLCHTDLKPEERKTC 1727
Score = 113 bits (282), Expect = 2e-24
Identities = 67/181 (37%), Positives = 87/181 (48%), Gaps = 15/181 (8%)
Query: 821 PVFSWHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQPCP 880
P W YG W +CT CG G++ + V C + C+ L +P D++ +C+ CP
Sbjct: 1382 PCPQWAYGNWGECTKLCGGGIRTRLVVCQRSNGERFPDLSCEILDKPPDRE-QCNTHACP 1440
Query: 881 --ARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPCNR 938
A W G W CS SCG G +R V C+ G S LE C+HL +P C R
Sbjct: 1441 HDAAWSTGPWSSCSVSCGRGH-KQRNVYCMAKDG----SHLESDYCKHLAKPHGHRKC-R 1494
Query: 939 HVPCPATWAVGNWSQCSVTCGEGTQRRNVLCTNDT-----GVPCDEAQQPASEVTCSLPL 993
CP W G WSQCSV+CG G Q+R+V C T C+ +P SE C P
Sbjct: 1495 GGRCP-KWKAGAWSQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQGPR 1553
Query: 994 C 994
C
Sbjct: 1554 C 1554
Score = 112 bits (280), Expect = 3e-24
Identities = 67/183 (36%), Positives = 86/183 (46%), Gaps = 18/183 (9%)
Query: 825 WHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQPCPARWW 884
W GPW C+ TC G QR+ V C + ++ C +PD+Q R C PCP +W
Sbjct: 1332 WRTGPWGACSSTCAGGSQRRVVVCQDENGYTAND--CVERIKPDEQ-RACESGPCP-QWA 1387
Query: 885 AGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPCNRHVPCP- 943
G W C+ CG GG+ R V+C RS G +CE L +PP CN H CP
Sbjct: 1388 YGNWGECTKLCG-GGIRTRLVVCQRSNG----ERFPDLSCEILDKPPDREQCNTHA-CPH 1441
Query: 944 -ATWAVGNWSQCSVTCGEGTQRRNVLCTNDTGVP-----CDEAQQPASEVTCSLPLC-RW 996
A W+ G WS CSV+CG G ++RNV C G C +P C C +W
Sbjct: 1442 DAAWSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLESDYCKHLAKPHGHRKCRGGRCPKW 1501
Query: 997 PLG 999
G
Sbjct: 1502 KAG 1504
Score = 107 bits (266), Expect = 1e-22
Identities = 75/231 (32%), Positives = 101/231 (43%), Gaps = 37/231 (16%)
Query: 820 PPVFSWHYGPWTKCTVTCGRGVQRQNVYC-LERQAGPVDEEHCDPLGRPDDQQ------- 871
P SW GPW +C+VTCG+G Q + V C + VD+ C+ RP D Q
Sbjct: 1106 PECASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSC 1165
Query: 872 ---------RKCSEQPCPARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPP 922
R+ + +W G W CS++CG G R V C G S +
Sbjct: 1166 HPPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGK-GTRMRYVSCRDENG----SVADES 1220
Query: 923 ACEHLPRPPTETPCNRHVPCPATWAVGNWSQCSVTCGEGTQRRNVLCTNDTG-----VPC 977
AC LPRP + C+ PC W +WS CSVTCG+G R V+C N + C
Sbjct: 1221 ACATLPRPVAKEECS-VTPC-GQWKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDRSEC 1278
Query: 978 DEAQQPASEVTCSLPLCRWPLGTLGPEGSGSGSSSHELFNEADFIPHHLAP 1028
D+ P ++ CS+ C P T SG + H NE D+ P +P
Sbjct: 1279 DQDYIPETDQDCSMSPC--PQRT-----PDSGLAQHPFQNE-DYRPRSASP 1321
Score = 102 bits (254), Expect = 3e-21
Identities = 64/214 (29%), Positives = 92/214 (42%), Gaps = 35/214 (16%)
Query: 821 PVFSWHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQPCP 880
P W +G WT C+ TCG+G + + V C + DE C L RP ++ +CS PC
Sbjct: 1182 PRTQWRFGSWTPCSATCGKGTRMRYVSCRDENGSVADESACATLPRPVAKE-ECSVTPC- 1239
Query: 881 ARWWAGEWQLCSSSCGPGGLSRRAVLCIRS--------------VGLDEQSALEPPACEH 926
+W A +W CS +CG G +R+ V+C+ + +Q P +
Sbjct: 1240 GQWKALDWSSCSVTCGQGRATRQ-VMCVNYSDHVIDRSECDQDYIPETDQDCSMSPCPQR 1298
Query: 927 LP--------------RPPTETPCNRHVPCPATWAVGNWSQCSVTCGEGTQRRNVLCTND 972
P RP + +P HV W G W CS TC G+QRR V+C ++
Sbjct: 1299 TPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCAGGSQRRVVVCQDE 1358
Query: 973 TGV---PCDEAQQPASEVTC-SLPLCRWPLGTLG 1002
G C E +P + C S P +W G G
Sbjct: 1359 NGYTANDCVERIKPDEQRACESGPCPQWAYGNWG 1392
Score = 101 bits (251), Expect = 7e-21
Identities = 65/195 (33%), Positives = 93/195 (47%), Gaps = 28/195 (14%)
Query: 821 PVFSWHYGPWTKCTVTCGRGVQRQNVYCLERQAGP--VDEEHCDPLGRPDDQQRKCSEQP 878
P W G W++C VTCG+G + + V+C Q G +++ CDP +P Q C +
Sbjct: 1052 PCPQWKSGDWSECLVTCGKGHKHRQVWC---QFGEDRLNDRMCDPETKPTSMQT-CQQPE 1107
Query: 879 CPARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGL------DEQSALEP--------PAC 924
C A W AG W CS +CG G RAV CI + D +A P P+C
Sbjct: 1108 C-ASWQAGPWGQCSVTCGQG-YQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSC 1165
Query: 925 EHLPRPPTETPCNRHVPCPATWAVGNWSQCSVTCGEGTQRRNVLCTNDTGVPCDEA---- 980
P P ET + + W G+W+ CS TCG+GT+ R V C ++ G DE+
Sbjct: 1166 HPPPAAP-ETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCRDENGSVADESACAT 1224
Query: 981 -QQPASEVTCSLPLC 994
+P ++ CS+ C
Sbjct: 1225 LPRPVAKEECSVTPC 1239
Score = 91.7 bits (226), Expect = 6e-18
Identities = 58/212 (27%), Positives = 80/212 (37%), Gaps = 48/212 (22%)
Query: 821 PVFSWHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQPCP 880
P W W+ C+VTCG+G + V C+ +D CD P+ Q CS PCP
Sbjct: 1238 PCGQWKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDRSECDQDYIPETDQ-DCSMSPCP 1296
Query: 881 AR---------------------------------WWAGEWQLCSSSCGPGGLSRRAVLC 907
R W G W CSS+C GG RR V+C
Sbjct: 1297 QRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCA-GGSQRRVVVC 1355
Query: 908 IRSVGLDEQSALEPPACEHLPRPPTETPCNRHVPCPATWAVGNWSQCSVTCGEGTQRRNV 967
+++ C +P + C PCP WA GNW +C+ CG G + R V
Sbjct: 1356 ------QDENGYTANDCVERIKPDEQRACESG-PCP-QWAYGNWGECTKLCGGGIRTRLV 1407
Query: 968 LCTNDTG-----VPCDEAQQPASEVTCSLPLC 994
+C G + C+ +P C+ C
Sbjct: 1408 VCQRSNGERFPDLSCEILDKPPDREQCNTHAC 1439
Score = 74.7 bits (182), Expect = 7e-13
Identities = 48/163 (29%), Positives = 65/163 (39%), Gaps = 17/163 (10%)
Query: 1466 WHS-GNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAHRPCGAQPCLSW 1524
W+S G W CS+ C G R + C D + C P PCG L W
Sbjct: 881 WNSHGPWQACSKPCQGERK-RKLVCTRESDQLTVSDQRCDRLPQPGHITEPCGTDCDLRW 939
Query: 1525 YTSSWRECSEACGGGEQQRLVTCP------------EPGLCEEALRPNTTRPCNTHPCT- 1571
+ +S ECS CG G + + C + G C +P+ C+ T
Sbjct: 940 HVASRSECSAQCGLGYRTLDIYCAKYSRLDGKTEKVDDGFCSSHPKPSNREKCSGECNTG 999
Query: 1572 QWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHE 1614
W W +CS C GG QRR CVNT+ + D +C H+
Sbjct: 1000 GWRYSAWTECSKSCDGGTQRRRAICVNTRNDV--LDDSKCTHQ 1040
Score = 57.4 bits (137), Expect = 1e-07
Identities = 32/96 (33%), Positives = 48/96 (50%), Gaps = 8/96 (8%)
Query: 820 PPVFSWHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEH-----CDPLGRPDDQQRKC 874
P + W G W++C+VTCG+G +++ V C E G + E+ + G C
Sbjct: 1611 PCEYVWITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPC 1670
Query: 875 SEQPCP--ARWWAGEWQLCSSSCGPGGLSRRAVLCI 908
+ CP A W G W CS SCG G+ +R+V C+
Sbjct: 1671 YLRDCPVSATWRVGNWGSCSVSCGV-GVMQRSVQCL 1705
Score = 45.8 bits (107), Expect = 3e-04
Identities = 25/75 (33%), Positives = 34/75 (45%), Gaps = 22/75 (29%)
Query: 1389 PETQPLAPSLAEAGPPADPLVVRN----AGWQAGNWSECSTTCGLGAVWRPVRCSSGRDE 1444
P TQP P P +R+ A W+ GNW CS +CG+G + R V+C + D
Sbjct: 1660 PGTQP---------PSVHPCYLRDCPVSATWRVGNWGSCSVSCGVGVMQRSVQCLTNED- 1709
Query: 1445 DCAPAGRPQPARRCH 1459
QP+ CH
Sbjct: 1710 --------QPSHLCH 1716
Score = 38.9 bits (89), Expect = 0.043
Identities = 21/71 (29%), Positives = 30/71 (42%), Gaps = 11/71 (15%)
Query: 803 HYEYTIHREAGGHDEVPPPVF-----------SWHYGPWTKCTVTCGRGVQRQNVYCLER 851
+YEY+ PP V +W G W C+V+CG GV +++V CL
Sbjct: 1648 NYEYSYQTTINCPGTQPPSVHPCYLRDCPVSATWRVGNWGSCSVSCGVGVMQRSVQCLTN 1707
Query: 852 QAGPVDEEHCD 862
+ P H D
Sbjct: 1708 EDQPSHLCHTD 1718
>gi|124430557 a disintegrin-like and metalloprotease with
thrombospondin type 1 motifs 20 [Homo sapiens]
Length = 1910
Score = 532 bits (1370), Expect = e-150
Identities = 336/993 (33%), Positives = 498/993 (50%), Gaps = 68/993 (6%)
Query: 44 DIVHPVRVDAGGS-FLSYELWPRALRKRDVSVRRDAPAFYELQYRGRELRFNLTANQHLL 102
++V P RV+ G F + R R + Y G+ + NLTA+ L
Sbjct: 41 EVVIPERVNEFGEVFPQSHHFSRQKRSSEALEPMPFRTHYRFTAYGQLFQLNLTADASFL 100
Query: 103 APGFVSE---TRRRGGLGRAHIRAHTPACHLLGEVQDPELEGGLAAISACDGLKGVFQLS 159
A G+ T RG + C G+V E A +S C GL G F+
Sbjct: 101 AAGYTEVHLGTPERGAWESDAGPSDLRHCFYRGQVNSQE--DYKAVVSLCGGLTGTFKGQ 158
Query: 160 NEDYFIEPL---DSAPARPGHAQPHVVYKRQAPERLAQR-----------GDSSAPSTCG 205
N +YF+EP+ D GH +PH++Y++ Q ++S P
Sbjct: 159 NGEYFLEPIMKADGNEYEDGHNKPHLIYRQDLNNSFLQTLKYCSVSESQIKETSLPFHTY 218
Query: 206 VQVYPELESRRER----WEQRQQWRRPRLRRLHQRSVSKEKWVETLVVADAKMVEYHGQP 261
+ +L +ER + + R +R +S +++E +V ADAK+V HG
Sbjct: 219 SNMNEDLNVMKERVLGHTSKNVPLKDERRHSRKKRLISYPRYIEIMVTADAKVVSAHGS- 277
Query: 262 QVESYVLTIMNMVAGLFHDPSIGNPIHITIVRLVLLEDEEEDLKITHHADNTLKSFCKWQ 321
+++Y+LT+M++VA ++ DPSIGN IHI +V+LV++ EEE I TLK+FC WQ
Sbjct: 278 NLQNYILTLMSIVATIYKDPSIGNLIHIVVVKLVMIHREEEGPVINFDGATTLKNFCSWQ 337
Query: 322 KSINMKGDAHPLHHDTAILLTRKDLCAAMNRPCETLGLSHVAGMCQPHRSCSINEDTGLP 381
++ N D HP HHDTA+L+TR+D+C++ + C LGLS++ +C P +SC INE+ GL
Sbjct: 338 QTQNDLDDVHPSHHDTAVLITREDICSSKEK-CNMLGLSYLGTICDPLQSCFINEEKGLI 396
Query: 382 LAFTVAHELGHSFGIQHDGSGNDCEPVGKRPFIMSPQLLYDAAPLTWSRCSRQYITRFLD 441
AFT+AHELGH+ G+QHD + E + +M+P L + +P +WS CSR+Y+T FLD
Sbjct: 397 SAFTIAHELGHTLGVQHDDNPRCKEMKVTKYHVMAPALSFHMSPWSWSNCSRKYVTEFLD 456
Query: 442 RGWGLCLDDPPAKDIIDFPSVPPGVLYDVSHQCRLQYGAYSAFCEDMDNVCHTLWCS--- 498
G+G CL D P ++I + PS PG YD + QC L +G S C + N+C LWC+
Sbjct: 457 TGYGECLLDKPDEEIYNLPSELPGSRYDGNKQCELAFGPGSQMCPHI-NICMHLWCTSTE 515
Query: 499 -VGTTCHSKLDAAVDGTRCGENKWCLSGECVPVGFRPEAVDGGWSGWSAWSICSRSCGMG 557
+ C ++ DGT CG C G CV V+G W W +S CSR+CG G
Sbjct: 516 KLHKGCFTQHVPPADGTDCGPGMHCRHGLCVNKETETRPVNGEWGPWEPYSSCSRTCGGG 575
Query: 558 VQSAERQCTQPTPKYKGRYCVGERKRFRLCNLQACPAGRPSFRHVQCS-----HFDAMLY 612
++SA R+C +P P+ G YCVG R +FR CN +CP G FR QCS H D
Sbjct: 576 IESATRRCNRPEPRNGGNYCVGRRMKFRSCNTDSCPKGTQDFREKQCSDFNGKHLDISGI 635
Query: 613 KGQLHTWVPVVNDV---NPCELHCRPANEYFAEKLRDAVVDGTPCYQVRASRDLCINGIC 669
+ W+P + + + C+L+C+ A + L+D V DGTPC + D+C+ G C
Sbjct: 636 PSNVR-WLPRYSGIGTKDRCKLYCQVAGTNYFYLLKDMVEDGTPC--GTETHDICVQGQC 692
Query: 670 KNVGCDFEIDSGAMEDRCGVCHGNGSTCHTVSGTFEEAEGLGYVDVGLIPAGAREIRIQE 729
GCD ++S A D+CGVC G+ S+C T++G F + GY V IPAGA + I++
Sbjct: 693 MAAGCDHVLNSSAKIDKCGVCGGDNSSCKTITGVFNSSH-YGYNVVVKIPAGATNVDIRQ 751
Query: 730 VAEAA----NFLALRSEDPEKYFLNGGWTIQWNG---DYQVAGTTFTYARRGN-WENLTS 781
+ + ++LAL S+ + NG + + + + Q T Y+ N E + S
Sbjct: 752 YSYSGQPDDSYLAL-SDAEGNFLFNGNFLLSTSKKEINVQGTRTVIEYSGSNNAVERINS 810
Query: 782 PGPTKEPVWIQLLFQES--NPGVHYEYTIHREAGGHDEVPPPVFSWH-YGPWTKCTVTCG 838
++ + +Q+L + NP VHY + I E +F+W YGPW CT C
Sbjct: 811 TNRQEKELILQVLCVGNLYNPDVHYSFNIPLEERS------DMFTWDPYGPWEGCTKMC- 863
Query: 839 RGVQRQNVYCLER-QAGPVDEEHCDPLGRPDDQQRKCSEQPCPARWWAGEWQLCSSSCGP 897
+G+QR+N+ C+ + V ++ CD L P + C+ C RW CSS CG
Sbjct: 864 QGLQRRNITCIHKSDHSVVSDKECDHLPLPSFVTQSCNTD-CELRWHVIGKSECSSQCGQ 922
Query: 898 GGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPCNRHVPCPAT-WAVGNWSQCSV 956
G + S+ + ++ C +PPT+ C H C T W WSQCS
Sbjct: 923 GYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKPPTQELC--HGNCVFTRWHYSEWSQCSR 980
Query: 957 TCGEGTQRRNVLCTNDTGVP-CDEAQQPASEVT 988
+CG G + R C N+ G D Q S VT
Sbjct: 981 SCGGGERSRESYCMNNFGHRLADNECQELSRVT 1013
Score = 135 bits (339), Expect = 4e-31
Identities = 82/231 (35%), Positives = 97/231 (41%), Gaps = 26/231 (11%)
Query: 1415 WQAGNWSECSTTCGLGAVWRPVRCSSGR----------DEDCAPAGRPQPARRCHLRPCA 1464
W SECS+ CG G + C D C +P CH
Sbjct: 908 WHVIGKSECSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKPPTQELCHGNCVF 967
Query: 1465 T-WHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAHRPCGAQPCLS 1523
T WH WS+CSRSCGGG R+ C++ R L CQ C C S
Sbjct: 968 TRWHYSEWSQCSRSCGGGERSRESYCMNNFGHR-LADNECQE--LSRVTRENCNEFSCPS 1024
Query: 1524 WYTSSWRECSEACGGGEQQRLVTCP------EPGLCEEALRPNTTRPCNTHPCTQWVVGP 1577
W S W EC CG G +QR V C G C + +P + PC H C W VGP
Sbjct: 1025 WAASEWSECLVTCGKGTKQRQVWCQLNVDHLSDGFCNSSTKPESLSPCELHTCASWQVGP 1084
Query: 1578 WGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPCGTEDC 1628
WG C+ CG G Q R VKCVN ED+ +C HEA SRP + C
Sbjct: 1085 WGPCTTTCGHGYQMRDVKCVNELASAVLEDT-EC-HEA----SRPSDRQSC 1129
Score = 132 bits (331), Expect = 4e-30
Identities = 77/239 (32%), Positives = 99/239 (41%), Gaps = 52/239 (21%)
Query: 1408 LVVRNAGWQAGNWSECSTTCGLGAVWRPVRCSSGRDED-----CAPAGRPQPARRCHLRP 1462
L+ + A W+ G+W+ CS +CG G R V C D CA RP C P
Sbjct: 1149 LIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRIADESYCAHLPRPAEIWDC-FTP 1207
Query: 1463 CATWHSGNWSKCSRSCGGGSSVRDVQCVDTR----------DLRPLRPFHCQPGPAKPPA 1512
C W +G+WS CS SCG G + R V C++ ++RPL C A PPA
Sbjct: 1208 CGEWQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENYCDPEVRPLMEQECSLA-ACPPA 1266
Query: 1513 HRPCGAQPCL------------------------------SWYTSSWRECSEACGGGEQQ 1542
H + P W T W CS +C GG Q
Sbjct: 1267 HSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCSGGLQH 1326
Query: 1543 RLVTCPE-----PGLCEEALRPNTTRPCNTHPCTQWVVGPWGQCSGPCGGGVQRRLVKC 1596
R V C + C+ A +P + C PC QW G WG+CS CGGG++ RLV C
Sbjct: 1327 RAVVCQDENGQSASYCDAASKPPELQQCGPGPCPQWNYGNWGECSQTCGGGIKSRLVIC 1385
Score = 130 bits (327), Expect = 1e-29
Identities = 76/246 (30%), Positives = 96/246 (39%), Gaps = 35/246 (14%)
Query: 1415 WQAGNWSECSTTCGLGAVWRPVRCSSGRDE----DCAPAGRPQPARRCHLRPCATWHSGN 1470
W A WSEC TCG G R V C D C + +P+ C L CA+W G
Sbjct: 1025 WAASEWSECLVTCGKGTKQRQVWCQLNVDHLSDGFCNSSTKPESLSPCELHTCASWQVGP 1084
Query: 1471 WSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAHRPCGAQPC--------- 1521
W C+ +CG G +RDV+CV+ L C ++P + C PC
Sbjct: 1085 WGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEA-SRPSDRQSCVLTPCSFISKLETA 1143
Query: 1522 ----------LSWYTSSWRECSEACGGGEQQRLVTC-------PEPGLCEEALRPNTTRP 1564
W SW CS +CG G Q R V+C + C RP
Sbjct: 1144 LLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRIADESYCAHLPRPAEIWD 1203
Query: 1565 CNTHPCTQWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPCG 1624
C T PC +W G W CS CG G R V C+N + D + C E P + C
Sbjct: 1204 CFT-PCGEWQAGDWSPCSASCGHGKTTRQVLCMNYHQPI---DENYCDPEVRPLMEQECS 1259
Query: 1625 TEDCEP 1630
C P
Sbjct: 1260 LAACPP 1265
Score = 130 bits (327), Expect = 1e-29
Identities = 98/329 (29%), Positives = 134/329 (40%), Gaps = 37/329 (11%)
Query: 1295 PPIAPLPEMKVRDSSLEPGTPSFPTPGPGSWDLQTVAVWGTFLPTTLTGLGHMPEPALNP 1354
P + PL E + ++ P FP S +Q T LP T L ++P
Sbjct: 1248 PEVRPLMEQECSLAACPPAHSHFP-----SSPVQPSYYLSTNLPLTQK-LEDNENQVVHP 1301
Query: 1355 GPKGQPESLSPEVPLSSRLL------STPAWDSPANSHRVPETQPLAPSLAEAGPPADPL 1408
+G P SS + D S + P L + GP P
Sbjct: 1302 SVRGNQWRTGPWGSCSSSCSGGLQHRAVVCQDENGQSASYCDAASKPPELQQCGPGPCPQ 1361
Query: 1409 VVRNAGWQAGNWSECSTTCGLGAVWRPVRCS--SGR---DEDCAPAGRPQPARRCHLRPC 1463
W GNW ECS TCG G R V C +G+ D +C +P +CH+ C
Sbjct: 1362 ------WNYGNWGECSQTCGGGIKSRLVICQFPNGQILEDHNCEIVNKPPSVIQCHMHAC 1415
Query: 1464 ---ATWHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAHRPCGAQP 1520
+WH W+ CS SCG G R+V C+D R L +C KPP H+ C +
Sbjct: 1416 PADVSWHQEPWTSCSASCGKGRKYREVFCIDQFQ-RKLEDTNCSQ-VQKPPTHKACRSVR 1473
Query: 1521 CLSWYTSSWRECSEACGGGEQQRLVTCPEPG-------LCEEALRPNTTRPCNTHPCTQW 1573
C SW +SW ECS CG G QQR V C G +C+++ RP + R C + C Q
Sbjct: 1474 CPSWKANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDCVQH 1533
Query: 1574 VVGPWGQ--CSGPCGGGVQRRLVKCVNTQ 1600
G+ CS C + ++C + Q
Sbjct: 1534 KGMERGRLNCSTSCERKDSHQRMECTDNQ 1562
Score = 120 bits (302), Expect = 9e-27
Identities = 82/270 (30%), Positives = 105/270 (38%), Gaps = 62/270 (22%)
Query: 1415 WQAGNWSECSTTCGLGAVWRPVRCSSGR---DED-CAPAGRPQPARRCHLRPCAT----- 1465
WQAG+WS CS +CG G R V C + DE+ C P RP + C L C
Sbjct: 1211 WQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENYCDPEVRPLMEQECSLAACPPAHSHF 1270
Query: 1466 -------------------------------------WHSGNWSKCSRSCGGGSSVRDVQ 1488
W +G W CS SC GG R V
Sbjct: 1271 PSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCSGGLQHRAVV 1330
Query: 1489 CVDTRDLRPLRPFHCQPGPAKPPAHRPCGAQPCLSWYTSSWRECSEACGGGEQQRLVTCP 1548
C D +C +KPP + CG PC W +W ECS+ CGGG + RLV C
Sbjct: 1331 CQDENGQSAS---YCDAA-SKPPELQQCGPGPCPQWNYGNWGECSQTCGGGIKSRLVICQ 1386
Query: 1549 EPG-------LCEEALRPNTTRPCNTHPC---TQWVVGPWGQCSGPCGGGVQRRLVKCVN 1598
P CE +P + C+ H C W PW CS CG G + R V C++
Sbjct: 1387 FPNGQILEDHNCEIVNKPPSVIQCHMHACPADVSWHQEPWTSCSASCGKGRKYREVFCID 1446
Query: 1599 TQTGLPEEDSDQCGHEAWPESSRPCGTEDC 1628
Q ED++ C P + + C + C
Sbjct: 1447 -QFQRKLEDTN-CSQVQKPPTHKACRSVRC 1474
Score = 118 bits (296), Expect = 4e-26
Identities = 80/289 (27%), Positives = 103/289 (35%), Gaps = 80/289 (27%)
Query: 1413 AGWQAGNWSECSTTCGLGAVWRPVRCSSG------RDEDCAPAGRPQPARRCHLRPC--- 1463
A WQ G W C+TTCG G R V+C + D +C A RP + C L PC
Sbjct: 1078 ASWQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTPCSFI 1137
Query: 1464 ----------------ATWHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGP 1507
A W G+W+ CS SCG G+ R V C D D R +C P
Sbjct: 1138 SKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALD-RIADESYCAHLP 1196
Query: 1508 AKPPAHRPCGAQPCLSWYTSSWRECSEACGGGEQQRLVTCP------EPGLCEEALRPNT 1561
+P C PC W W CS +CG G+ R V C + C+ +RP
Sbjct: 1197 -RPAEIWDC-FTPCGEWQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENYCDPEVRPLM 1254
Query: 1562 TRPCNTHPC------------------------------------------TQWVVGPWG 1579
+ C+ C QW GPWG
Sbjct: 1255 EQECSLAACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWG 1314
Query: 1580 QCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPCGTEDC 1628
CS C GG+Q R V C + + + C + P + CG C
Sbjct: 1315 SCSSSCSGGLQHRAVVCQDEN----GQSASYCDAASKPPELQQCGPGPC 1359
Score = 110 bits (275), Expect = 1e-23
Identities = 61/178 (34%), Positives = 88/178 (49%), Gaps = 15/178 (8%)
Query: 819 PPPVFSWHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQP 878
P P W+YG W +C+ TCG G++ + V C +++ +C+ + +P +C
Sbjct: 1356 PGPCPQWNYGNWGECSQTCGGGIKSRLVICQFPNGQILEDHNCEIVNKP-PSVIQCHMHA 1414
Query: 879 CPA--RWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPC 936
CPA W W CS+SCG G R V CI Q LE C + +PPT C
Sbjct: 1415 CPADVSWHQEPWTSCSASCGK-GRKYREVFCIDQF----QRKLEDTNCSQVQKPPTHKAC 1469
Query: 937 NRHVPCPATWAVGNWSQCSVTCGEGTQRRNVLCT-----NDTGVPCDEAQQPASEVTC 989
R V CP +W +W++CSVTCG G Q+R+V C CD++ +P S+ C
Sbjct: 1470 -RSVRCP-SWKANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRC 1525
Score = 107 bits (268), Expect = 7e-23
Identities = 69/195 (35%), Positives = 82/195 (42%), Gaps = 34/195 (17%)
Query: 824 SWHYGPWTKCTVTCGRGVQRQNVYCLERQAGPV-DEEHCDPLGRPDDQQRKCSEQPCP-- 880
SW GPW CT TCG G Q ++V C+ A V ++ C RP D+Q C PC
Sbjct: 1079 SWQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSDRQ-SCVLTPCSFI 1137
Query: 881 ----------------ARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPAC 924
A+W G W CS SCG G R V C ++ + C
Sbjct: 1138 SKLETALLPTVLIKKMAQWRHGSWTPCSVSCG-RGTQARYVSCRDAL----DRIADESYC 1192
Query: 925 EHLPRPPTETPCNRHVPCPATWAVGNWSQCSVTCGEGTQRRNVLCTN-----DTGVPCDE 979
HLPRP C PC W G+WS CS +CG G R VLC N D CD
Sbjct: 1193 AHLPRPAEIWDC--FTPC-GEWQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENY-CDP 1248
Query: 980 AQQPASEVTCSLPLC 994
+P E CSL C
Sbjct: 1249 EVRPLMEQECSLAAC 1263
Score = 106 bits (265), Expect = 2e-22
Identities = 63/195 (32%), Positives = 91/195 (46%), Gaps = 27/195 (13%)
Query: 816 DEVPPP---------VFS-WHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLG 865
D++ PP VF+ WHY W++C+ +CG G + + YC+ + + C L
Sbjct: 951 DQLKPPTQELCHGNCVFTRWHYSEWSQCSRSCGGGERSRESYCMNNFGHRLADNECQELS 1010
Query: 866 RPDDQQRKCSEQPCPARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACE 925
R + C+E CP+ W A EW C +CG G +R V C +V L C
Sbjct: 1011 RVT--RENCNEFSCPS-WAASEWSECLVTCGKG-TKQRQVWCQLNV-----DHLSDGFCN 1061
Query: 926 HLPRPPTETPCNRHVPCPATWAVGNWSQCSVTCGEGTQRRNVLCTNDTG------VPCDE 979
+P + +PC H C A+W VG W C+ TCG G Q R+V C N+ C E
Sbjct: 1062 SSTKPESLSPCELHT-C-ASWQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHE 1119
Query: 980 AQQPASEVTCSLPLC 994
A +P+ +C L C
Sbjct: 1120 ASRPSDRQSCVLTPC 1134
Score = 99.8 bits (247), Expect = 2e-20
Identities = 64/220 (29%), Positives = 87/220 (39%), Gaps = 57/220 (25%)
Query: 821 PVFSWHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQPCP 880
P W G W+ C+ +CG G + V C+ P+DE +CDP RP +Q +CS CP
Sbjct: 1207 PCGEWQAGDWSPCSASCGHGKTTRQVLCMNYHQ-PIDENYCDPEVRPLMEQ-ECSLAACP 1264
Query: 881 A-----------------------------------------RWWAGEWQLCSSSCGPGG 899
+W G W CSSSC GG
Sbjct: 1265 PAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCS-GG 1323
Query: 900 LSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPCNRHVPCPATWAVGNWSQCSVTCG 959
L RAV+C +++ C+ +PP C PCP W GNW +CS TCG
Sbjct: 1324 LQHRAVVC------QDENGQSASYCDAASKPPELQQCGPG-PCP-QWNYGNWGECSQTCG 1375
Query: 960 EGTQRRNVLCTNDTGV-----PCDEAQQPASEVTCSLPLC 994
G + R V+C G C+ +P S + C + C
Sbjct: 1376 GGIKSRLVICQFPNGQILEDHNCEIVNKPPSVIQCHMHAC 1415
Score = 96.3 bits (238), Expect = 2e-19
Identities = 69/217 (31%), Positives = 89/217 (41%), Gaps = 43/217 (19%)
Query: 825 WHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQPCPARWW 884
W +G WT C+V+CGRG Q + V C + DE +C L RP + C PC W
Sbjct: 1156 WRHGSWTPCSVSCGRGTQARYVSCRDALDRIADESYCAHLPRPAEIW-DCF-TPC-GEWQ 1212
Query: 885 AGEWQLCSSSCGPGGLSRRAVLC---------------IRSVGLDEQS-ALEPPACEHLP 928
AG+W CS+SCG G +R+ VLC +R + E S A PPA H P
Sbjct: 1213 AGDWSPCSASCGHGKTTRQ-VLCMNYHQPIDENYCDPEVRPLMEQECSLAACPPAHSHFP 1271
Query: 929 RPPTETPCNRHVPCPAT-------------------WAVGNWSQCSVTCGEGTQRRNVLC 969
P + P T W G W CS +C G Q R V+C
Sbjct: 1272 SSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCSGGLQHRAVVC 1331
Query: 970 TNDTGVP---CDEAQQPASEVTCSLPLC-RWPLGTLG 1002
++ G CD A +P C C +W G G
Sbjct: 1332 QDENGQSASYCDAASKPPELQQCGPGPCPQWNYGNWG 1368
Score = 95.5 bits (236), Expect = 4e-19
Identities = 73/246 (29%), Positives = 105/246 (42%), Gaps = 33/246 (13%)
Query: 1410 VRNAGWQAGNWSECSTTCGLGAVWRPVRC-----SSGRDEDCAPAGRPQPARRCHLRPCA 1464
VR W+A +W+ECS TCG G R V C +E C + RP RRC + C
Sbjct: 1472 VRCPSWKANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDCV 1531
Query: 1465 TWHSG---NWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAHRPCGAQPC 1521
H G CS SC S + ++C D + +R + + + C PC
Sbjct: 1532 Q-HKGMERGRLNCSTSCERKDSHQRMECTDNQ-IRQVNEIVYNSSTISLTS-KNCRNPPC 1588
Query: 1522 -LSWYTSSWRECSEACGGGEQQRLVTCPEPGLCEE----ALRPNTTRPCNTHPCTQ---- 1572
T+ +C+ CG +QR+ C E ++ LRP + C P +Q
Sbjct: 1589 NYIVVTADSSQCANNCGFSYRQRITYCTEIPSTKKHKLHRLRPIVYQECPVVPSSQVYQC 1648
Query: 1573 ---------WVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPC 1623
W VG W +CS CG G+ +R VKC+ T+ GL SD C + P + + C
Sbjct: 1649 INSCLHLATWKVGKWSKCSVTCGIGIMKRQVKCI-TKHGL---SSDLCLNHLKPGAQKKC 1704
Query: 1624 GTEDCE 1629
DC+
Sbjct: 1705 YANDCK 1710
Score = 77.0 bits (188), Expect = 1e-13
Identities = 46/184 (25%), Positives = 82/184 (44%), Gaps = 9/184 (4%)
Query: 815 HDEVPPPVFSWHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKC 874
H P SWH PWT C+ +CG+G + + V+C+++ +++ +C + +P + C
Sbjct: 1411 HMHACPADVSWHQEPWTSCSASCGKGRKYREVFCIDQFQRKLEDTNCSQVQKP-PTHKAC 1469
Query: 875 SEQPCPARWWAGEWQLCSSSCGPGGLSRRAVLC-IRSVGLDEQSALEPPACEHLPRPPTE 933
CP+ W A W CS +CG G+ +R V C ++ VG + C+ RP ++
Sbjct: 1470 RSVRCPS-WKANSWNECSVTCG-SGVQQRDVYCRLKGVG-----QVVEEMCDQSTRPCSQ 1522
Query: 934 TPCNRHVPCPATWAVGNWSQCSVTCGEGTQRRNVLCTNDTGVPCDEAQQPASEVTCSLPL 993
C CS +C + + CT++ +E +S ++ +
Sbjct: 1523 RRCWSQDCVQHKGMERGRLNCSTSCERKDSHQRMECTDNQIRQVNEIVYNSSTISLTSKN 1582
Query: 994 CRWP 997
CR P
Sbjct: 1583 CRNP 1586
Score = 67.4 bits (163), Expect = 1e-10
Identities = 45/148 (30%), Positives = 62/148 (41%), Gaps = 8/148 (5%)
Query: 824 SWHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQPCPARW 883
SW W +C+VTCG GVQ+++VYC + G V EE CD RP QR+C Q C
Sbjct: 1476 SWKANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRP-CSQRRCWSQDCVQHK 1534
Query: 884 WAGEWQL-CSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPCNRHVPC 942
+L CS+SC +R + + + PCN V
Sbjct: 1535 GMERGRLNCSTSCERKDSHQRMECTDNQIRQVNEIVYNSSTISLTSKNCRNPPCNYIV-- 1592
Query: 943 PATWAVGNWSQCSVTCGEGTQRRNVLCT 970
+ SQC+ CG ++R CT
Sbjct: 1593 ----VTADSSQCANNCGFSYRQRITYCT 1616
Score = 65.1 bits (157), Expect = 6e-10
Identities = 56/229 (24%), Positives = 80/229 (34%), Gaps = 35/229 (15%)
Query: 1465 TWHS-GNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAHRPCGAQPCLS 1523
TW G W C++ C G R++ C+ D + C P + C L
Sbjct: 849 TWDPYGPWEGCTKMCQGLQR-RNITCIHKSDHSVVSDKECDHLPLPSFVTQSCNTDCELR 907
Query: 1524 WYTSSWRECSEACGGGEQQRLVTCPEPGL------------CEEALRPNTTRPCNTH-PC 1570
W+ ECS CG G + + C + + C + L+P T C+ +
Sbjct: 908 WHVIGKSECSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKPPTQELCHGNCVF 967
Query: 1571 TQWVVGPWGQCSGPCGGGVQRRLVKCVN-----------------TQTGLPEEDSDQCGH 1613
T+W W QCS CGGG + R C+N T+ E
Sbjct: 968 TRWHYSEWSQCSRSCGGGERSRESYCMNNFGHRLADNECQELSRVTRENCNEFSCPSWAA 1027
Query: 1614 EAWPESSRPCGTEDCEPVEPPRCERDRLSFGFCETL---RLLGRCQLPT 1659
W E CG + + D LS GFC + L C+L T
Sbjct: 1028 SEWSECLVTCGKGTKQRQVWCQLNVDHLSDGFCNSSTKPESLSPCELHT 1076
Score = 46.2 bits (108), Expect = 3e-04
Identities = 40/140 (28%), Positives = 55/140 (39%), Gaps = 27/140 (19%)
Query: 1403 PPADPLVVRNAGWQAGNWSECSTTCGLGAVWRPVRCSSGRDEDCAPAGRPQPA--RRCHL 1460
PP + +VV + S+C+ CG R C+ R +P + C +
Sbjct: 1586 PPCNYIVV------TADSSQCANNCGFSYRQRITYCTEIPSTKKHKLHRLRPIVYQECPV 1639
Query: 1461 RPC-------------ATWHSGNWSKCSRSCGGGSSVRDVQCVDTRDL-RPLRPFHCQPG 1506
P ATW G WSKCS +CG G R V+C+ L L H +PG
Sbjct: 1640 VPSSQVYQCINSCLHLATWKVGKWSKCSVTCGIGIMKRQVKCITKHGLSSDLCLNHLKPG 1699
Query: 1507 PAKPPAHRPCGAQPCLSWYT 1526
A + C A C S+ T
Sbjct: 1700 -----AQKKCYANDCKSFTT 1714
Score = 40.4 bits (93), Expect = 0.015
Identities = 19/58 (32%), Positives = 28/58 (48%), Gaps = 7/58 (12%)
Query: 824 SWHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVD--EEHCDPLGRPDDQQRKCSEQPC 879
+W G W+KC+VTCG G+ ++ V C+ + D H P Q+KC C
Sbjct: 1657 TWKVGKWSKCSVTCGIGIMKRQVKCITKHGLSSDLCLNHLKP-----GAQKKCYANDC 1709
Score = 33.1 bits (74), Expect = 2.3
Identities = 36/129 (27%), Positives = 47/129 (36%), Gaps = 18/129 (13%)
Query: 1530 RECSEACGGGEQQRLVTCPEPGLCEEALRPNTTRPCNTHPCTQWVVGPWGQCSGPCGGGV 1589
++C A G G Q CP +C L +T + TQ V G CG G+
Sbjct: 487 KQCELAFGPGSQM----CPHINICMH-LWCTSTEKLHKGCFTQHVPPADGT---DCGPGM 538
Query: 1590 QRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPCG------TEDCEPVEPPR----CERD 1639
R CVN +T + + E + SR CG T C EP C
Sbjct: 539 HCRHGLCVNKETETRPVNGEWGPWEPYSSCSRTCGGGIESATRRCNRPEPRNGGNYCVGR 598
Query: 1640 RLSFGFCET 1648
R+ F C T
Sbjct: 599 RMKFRSCNT 607
Score = 33.1 bits (74), Expect = 2.3
Identities = 20/60 (33%), Positives = 25/60 (41%), Gaps = 4/60 (6%)
Query: 544 WSA--WSICSRSCGMGVQSAERQCTQPTPKYKGRYCVGERKRF--RLCNLQACPAGRPSF 599
W A WS CS SCG G + + C YC E + + C+L ACP F
Sbjct: 1211 WQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENYCDPEVRPLMEQECSLAACPPAHSHF 1270
Score = 32.3 bits (72), Expect = 4.0
Identities = 24/81 (29%), Positives = 32/81 (39%), Gaps = 16/81 (19%)
Query: 1551 GLCEEALRPNTTRPCNTHPCTQWVVGPW---GQCSGPCGGGVQRRLVKCVNTQTGLPEED 1607
GLC + TRP N +W GPW CS CGGG++ +C + P
Sbjct: 543 GLCVN--KETETRPVNG----EW--GPWEPYSSCSRTCGGGIESATRRCNRPE---PRNG 591
Query: 1608 SDQCGHEAWPESSRPCGTEDC 1628
+ C R C T+ C
Sbjct: 592 GNYCVGRRM--KFRSCNTDSC 610
>gi|110611167 ADAM metallopeptidase with thrombospondin type 1 motif,
14 isoform 1 preproprotein [Homo sapiens]
Length = 1226
Score = 508 bits (1308), Expect = e-143
Identities = 388/1267 (30%), Positives = 568/1267 (44%), Gaps = 163/1267 (12%)
Query: 29 PGPAPGRATEGRAALDIVHPVRVDAGGSFLSYELWPRALRKRDVSVRRDAPAFYELQYRG 88
P P ++ R A +HP GG+ LWP + + + ++ + G
Sbjct: 73 PPTLPRHSSHLRVARSPLHP-----GGT-----LWPGRVGRHSL--------YFNVTVFG 114
Query: 89 RELRFNLTANQHLLAPGFVSETRRR-GGLGRAHIRAHTPACHLLGEVQDPELEGGLAAIS 147
+EL L N+ L+ PG E + L R +R C G V + G AIS
Sbjct: 115 KELHLRLRPNRRLVVPGSSVEWQEDFRELFRQPLRQE---CVYTGGVTG--MPGAAVAIS 169
Query: 148 ACDGLKGVFQLSNEDYFIEPLDSAPA-RPGHAQPHVVYKRQAPERLAQRGDSSAPSTC-G 205
CDGL G+ + + D+FIEPL+ + + HVVY+R+A ++ D + G
Sbjct: 170 NCDGLAGLIRTDSTDFFIEPLERGQQEKEASGRTHVVYRREAVQQEWAEPDGDLHNEAFG 229
Query: 206 VQVYPELESRRERWEQRQQWRRPRLRRLHQRSVSKEKWVETLVVADAKMVEYHGQPQVES 265
+ P L Q +R H + S +E L+V D +V +HG+ V++
Sbjct: 230 LGDLPNLLGL-----VGDQLGDTERKRRHAKPGSYS--IEVLLVVDDSVVRFHGKEHVQN 282
Query: 266 YVLTIMNMVAGLFHDPSIGNPIHITIVRLVLLEDEEEDLKITH-HADNTLKSFCKWQKSI 324
YVLT+MN+V ++HD S+G I+I +VRL+++ + I + +L+ C+W S
Sbjct: 283 YVLTLMNIVDEIYHDESLGVHINIALVRLIMVGYRQSLSLIERGNPSRSLEQVCRWAHSQ 342
Query: 325 NMKGDAHPLHHDTAILLTRKDLCAAMNRPCETLGLSHVAGMCQPHRSCSINEDTGLPLAF 384
+ +H HHD + LTR+D P G + V GMC P RSC++N + G AF
Sbjct: 343 QRQDPSHAEHHDHVVFLTRQDF-----GPSGMQGYAPVTGMCHPLRSCALNHEDGFSSAF 397
Query: 385 TVAHELGHSFGIQHDGSGNDCEPVGKRPFIMSPQLLYDAAPLTWSRCSRQYITRFLDRGW 444
+AHE GH G++HDG GN C +M+P + WSRCS+ ++R+L +
Sbjct: 398 VIAHETGHVLGMEHDGQGNGCADETSLGSVMAPLVQAAFHRFHWSRCSKLELSRYLP-SY 456
Query: 445 GLCLDDP--PAKDIIDFPSVP--PGVLYDVSHQCRLQYGAYSAFCEDMDNV--CHTLWCS 498
LDDP PA +P P PG+ Y + QCR +G+ C C LWCS
Sbjct: 457 DCLLDDPFDPA-----WPQPPELPGINYSMDEQCRFDFGSGYQTCLAFRTFEPCKQLWCS 511
Query: 499 VGTT---CHSKLDAAVDGTRCGENKWCLSGECVPVGFRPEAV---DGGWSGWSAWSICSR 552
C +K +DGT C KWC G C+ PE DGGWS W+ + CSR
Sbjct: 512 HPDNPYFCKTKKGPPLDGTECAPGKWCFKGHCIWKS--PEQTYGQDGGWSSWTKFGSCSR 569
Query: 553 SCGMGVQSAERQCTQPTPKYKGRYCVGERKRFRLCNLQACPAGRPSFRHVQCSHFDA-ML 611
SCG GV+S R C P+P Y GR C+G +++CN + CP FR QC+ ++ +
Sbjct: 570 SCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECPGTYEDFRAQQCAKRNSYYV 629
Query: 612 YKGQLHTWVPVV--NDVNPCELHCRPANEYFAEKLRDAVVDGTPCYQVRASRDLCINGIC 669
++ H+WVP +D CEL C+ A+ + V DGT C R +C G C
Sbjct: 630 HQNAKHSWVPYEPDDDAQKCELICQSADTGDVVFMNQVVHDGTRC-SYRDPYSVCARGEC 688
Query: 670 KNVGCDFEIDSGAMEDRCGVCHGNGSTCHTVSGTFEEA-EGLGYVDVGLIPAGAREIRIQ 728
VGCD E+ S +D+CGVC G+ S C TV GT +A + G + + IPAGAR I+I+
Sbjct: 689 VPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASKQAGALKLVQIPAGARHIQIE 748
Query: 729 EVAEAANFLALRSEDPEKYFLNGGWTIQWNGDYQVAGTTFTYARRGNWENLTSPGPTKEP 788
+ ++ + + ++++ + LN + + G + A E+L + GP E
Sbjct: 749 ALEKSPHRIVVKNQVTGSFILNPKGKEATSRTFTAMGLEWEDAVEDAKESLKTSGPLPEA 808
Query: 789 VWIQLL-FQESNP--GVHYEYTIHRE----AGGHDEV--PPPVFSWHYGPWTKCTVTCGR 839
+ I L E P + Y+Y IH + G ++ + + W W C+ CG
Sbjct: 809 IAILALPPTEGGPRSSLAYKYVIHEDLLPLIGSNNVLLEEMDTYEWALKSWAPCSKACGG 868
Query: 840 GVQRQNVYCLERQAGPVDEEH-CDPLGRPDDQQRKCSEQPCPAR-WWAGEWQLCSSSCGP 897
G+Q C R+ + + H CD RP +R+C++ PC W EW CS SCG
Sbjct: 869 GIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQPVWVTEEWGACSRSCGK 928
Query: 898 GGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPCNRHVPCPATWAVGNWSQCSVT 957
G+ R + C+ + + AC RP PC R VPCPA W +G WSQCS T
Sbjct: 929 LGVQTRGIQCLLPLSNGTHKVMPAKACAG-DRPEARRPCLR-VPCPAQWRLGAWSQCSAT 986
Query: 958 CGEGTQRRNVLC-TNDTGVPCDEAQQPASEVTCSLPLCR------------WPLGTLGPE 1004
CGEG Q+R V+C TN + E +P + CSLP C W LGT PE
Sbjct: 987 CGEGIQQRQVVCRTNANSLGHCEGDRPDTVQVCSLPACGGNHQNSTVRADVWELGT--PE 1044
Query: 1005 GSGSGSSSHELFNEADFIPHHLAPRP-SPASSPKPGTMGNAIEEEAPELD----LPGPVF 1059
G ++P P + SS +P T ++ + LD +PG
Sbjct: 1045 G--------------QWVPQSEPLHPINKISSTEPCTGDRSVFCQMEVLDRYCSIPG--- 1087
Query: 1060 VDDFYYDYNFINFHEDLSYGPSEEPDLDLAGTGDRTPPPHSHPAAPSTGSPVPATEPPAA 1119
Y+ ++ + S GP+ PD P P S P + GSP+P + PA
Sbjct: 1088 ----YHRLCCVSCIKKAS-GPNPGPD----------PGPTSLPPFSTPGSPLPGPQDPAD 1132
Query: 1120 KEEGVLGPWSPSPWPSQAGRSPPPPSEQTPGNPLINFLPEEDTPIGAPDLGLPSLSWPRV 1179
E P P+ + + Q PG L P P AP+ +P SW
Sbjct: 1133 AAE-------PPGKPTGSEDHQHGRATQLPG-ALDTSSPGTQHPF-APETPIPGASWS-- 1181
Query: 1180 STDGLQTPATPESQNDFPVGKDSQSQLPPPWRDRTNEVFKDDEEPKGRGAPHLPPRPSST 1239
+P TP LP W V +D +P G H P ++
Sbjct: 1182 -----ISPTTP-------------GGLPWGWTQTPTPVPEDKGQP-GEDLRH----PGTS 1218
Query: 1240 LPPLSPV 1246
LP SPV
Sbjct: 1219 LPAASPV 1225
Score = 104 bits (259), Expect = 8e-22
Identities = 89/282 (31%), Positives = 108/282 (38%), Gaps = 55/282 (19%)
Query: 1415 WQAGNWSECSTTCGLGAVWRPVRCSSGRDED------CAPAGRPQP-ARRCHLRPCA--T 1465
W +W+ CS CG G + C RD C RP+P RRC+ PC+
Sbjct: 854 WALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQPV 913
Query: 1466 WHSGNWSKCSRSCGG-GSSVRDVQCVDTRDLRPLRPFHCQPGPAK------PPAHRPCGA 1518
W + W CSRSCG G R +QC L PL + PAK P A RPC
Sbjct: 914 WVTEEWGACSRSCGKLGVQTRGIQC-----LLPLSNGTHKVMPAKACAGDRPEARRPCLR 968
Query: 1519 QPC-LSWYTSSWRECSEACGGGEQQRLVTC----PEPGLCEEALRPNTTRPCNTHPCTQW 1573
PC W +W +CS CG G QQR V C G C E RP+T + C+
Sbjct: 969 VPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHC-EGDRPDTVQVCSL------ 1021
Query: 1574 VVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPC-GTEDCEPVE 1632
CGG Q V+ + G PE W S P E
Sbjct: 1022 ---------PACGGNHQNSTVRADVWELGTPEGQ--------WVPQSEPLHPINKISSTE 1064
Query: 1633 PPRCERDRLSFGFCETLRLLGRCQLPTIRTQCCRSCSPPSHG 1674
P C DR FC+ L C +P CC SC + G
Sbjct: 1065 P--CTGDRSV--FCQMEVLDRYCSIPGYHRLCCVSCIKKASG 1102
Score = 40.4 bits (93), Expect = 0.015
Identities = 27/87 (31%), Positives = 36/87 (41%), Gaps = 2/87 (2%)
Query: 1385 SHRVPETQPLAPSLAEAGPPADPLVVRNAGWQAGNWSECSTTCGLGAVWRPVRCSSGRDE 1444
+H+V + A EA P V A W+ G WS+CS TCG G R V C + +
Sbjct: 946 THKVMPAKACAGDRPEARRPC-LRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANS 1004
Query: 1445 -DCAPAGRPQPARRCHLRPCATWHSGN 1470
RP + C L C H +
Sbjct: 1005 LGHCEGDRPDTVQVCSLPACGGNHQNS 1031
>gi|21265052 ADAM metallopeptidase with thrombospondin type 1 motif,
14 isoform 2 preproprotein [Homo sapiens]
Length = 1223
Score = 506 bits (1303), Expect = e-143
Identities = 387/1267 (30%), Positives = 568/1267 (44%), Gaps = 166/1267 (13%)
Query: 29 PGPAPGRATEGRAALDIVHPVRVDAGGSFLSYELWPRALRKRDVSVRRDAPAFYELQYRG 88
P P ++ R A +HP GG+ LWP + + + ++ + G
Sbjct: 73 PPTLPRHSSHLRVARSPLHP-----GGT-----LWPGRVGRHSL--------YFNVTVFG 114
Query: 89 RELRFNLTANQHLLAPGFVSETRRR-GGLGRAHIRAHTPACHLLGEVQDPELEGGLAAIS 147
+EL L N+ L+ PG E + L R +R C G V + G AIS
Sbjct: 115 KELHLRLRPNRRLVVPGSSVEWQEDFRELFRQPLRQE---CVYTGGVTG--MPGAAVAIS 169
Query: 148 ACDGLKGVFQLSNEDYFIEPLDSAPA-RPGHAQPHVVYKRQAPERLAQRGDSSAPSTC-G 205
CDGL G+ + + D+FIEPL+ + + HVVY+R+A ++ D + G
Sbjct: 170 NCDGLAGLIRTDSTDFFIEPLERGQQEKEASGRTHVVYRREAVQQEWAEPDGDLHNEAFG 229
Query: 206 VQVYPELESRRERWEQRQQWRRPRLRRLHQRSVSKEKWVETLVVADAKMVEYHGQPQVES 265
+ P L Q +R H + S +E L+V D +V +HG+ V++
Sbjct: 230 LGDLPNLLGL-----VGDQLGDTERKRRHAKPGSYS--IEVLLVVDDSVVRFHGKEHVQN 282
Query: 266 YVLTIMNMVAGLFHDPSIGNPIHITIVRLVLLEDEEEDLKITH-HADNTLKSFCKWQKSI 324
YVLT+MN+V ++HD S+G I+I +VRL+++ + I + +L+ C+W S
Sbjct: 283 YVLTLMNIVDEIYHDESLGVHINIALVRLIMVGYRQSLSLIERGNPSRSLEQVCRWAHSQ 342
Query: 325 NMKGDAHPLHHDTAILLTRKDLCAAMNRPCETLGLSHVAGMCQPHRSCSINEDTGLPLAF 384
+ +H HHD + LTR+D + G + V GMC P RSC++N + G AF
Sbjct: 343 QRQDPSHAEHHDHVVFLTRQDFGPS--------GYAPVTGMCHPLRSCALNHEDGFSSAF 394
Query: 385 TVAHELGHSFGIQHDGSGNDCEPVGKRPFIMSPQLLYDAAPLTWSRCSRQYITRFLDRGW 444
+AHE GH G++HDG GN C +M+P + WSRCS+ ++R+L +
Sbjct: 395 VIAHETGHVLGMEHDGQGNGCADETSLGSVMAPLVQAAFHRFHWSRCSKLELSRYLP-SY 453
Query: 445 GLCLDDP--PAKDIIDFPSVP--PGVLYDVSHQCRLQYGAYSAFCEDMDNV--CHTLWCS 498
LDDP PA +P P PG+ Y + QCR +G+ C C LWCS
Sbjct: 454 DCLLDDPFDPA-----WPQPPELPGINYSMDEQCRFDFGSGYQTCLAFRTFEPCKQLWCS 508
Query: 499 VGTT---CHSKLDAAVDGTRCGENKWCLSGECVPVGFRPEAV---DGGWSGWSAWSICSR 552
C +K +DGT C KWC G C+ PE DGGWS W+ + CSR
Sbjct: 509 HPDNPYFCKTKKGPPLDGTECAPGKWCFKGHCIWKS--PEQTYGQDGGWSSWTKFGSCSR 566
Query: 553 SCGMGVQSAERQCTQPTPKYKGRYCVGERKRFRLCNLQACPAGRPSFRHVQCSHFDA-ML 611
SCG GV+S R C P+P Y GR C+G +++CN + CP FR QC+ ++ +
Sbjct: 567 SCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECPGTYEDFRAQQCAKRNSYYV 626
Query: 612 YKGQLHTWVPVV--NDVNPCELHCRPANEYFAEKLRDAVVDGTPCYQVRASRDLCINGIC 669
++ H+WVP +D CEL C+ A+ + V DGT C R +C G C
Sbjct: 627 HQNAKHSWVPYEPDDDAQKCELICQSADTGDVVFMNQVVHDGTRC-SYRDPYSVCARGEC 685
Query: 670 KNVGCDFEIDSGAMEDRCGVCHGNGSTCHTVSGTFEEA-EGLGYVDVGLIPAGAREIRIQ 728
VGCD E+ S +D+CGVC G+ S C TV GT +A + G + + IPAGAR I+I+
Sbjct: 686 VPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASKQAGALKLVQIPAGARHIQIE 745
Query: 729 EVAEAANFLALRSEDPEKYFLNGGWTIQWNGDYQVAGTTFTYARRGNWENLTSPGPTKEP 788
+ ++ + + ++++ + LN + + G + A E+L + GP E
Sbjct: 746 ALEKSPHRIVVKNQVTGSFILNPKGKEATSRTFTAMGLEWEDAVEDAKESLKTSGPLPEA 805
Query: 789 VWIQLL-FQESNP--GVHYEYTIHRE----AGGHDEV--PPPVFSWHYGPWTKCTVTCGR 839
+ I L E P + Y+Y IH + G ++ + + W W C+ CG
Sbjct: 806 IAILALPPTEGGPRSSLAYKYVIHEDLLPLIGSNNVLLEEMDTYEWALKSWAPCSKACGG 865
Query: 840 GVQRQNVYCLERQAGPVDEEH-CDPLGRPDDQQRKCSEQPCPAR-WWAGEWQLCSSSCGP 897
G+Q C R+ + + H CD RP +R+C++ PC W EW CS SCG
Sbjct: 866 GIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQPVWVTEEWGACSRSCGK 925
Query: 898 GGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPCNRHVPCPATWAVGNWSQCSVT 957
G+ R + C+ + + AC RP PC R VPCPA W +G WSQCS T
Sbjct: 926 LGVQTRGIQCLLPLSNGTHKVMPAKACAG-DRPEARRPCLR-VPCPAQWRLGAWSQCSAT 983
Query: 958 CGEGTQRRNVLC-TNDTGVPCDEAQQPASEVTCSLPLCR------------WPLGTLGPE 1004
CGEG Q+R V+C TN + E +P + CSLP C W LGT PE
Sbjct: 984 CGEGIQQRQVVCRTNANSLGHCEGDRPDTVQVCSLPACGGNHQNSTVRADVWELGT--PE 1041
Query: 1005 GSGSGSSSHELFNEADFIPHHLAPRP-SPASSPKPGTMGNAIEEEAPELD----LPGPVF 1059
G ++P P + SS +P T ++ + LD +PG
Sbjct: 1042 G--------------QWVPQSEPLHPINKISSTEPCTGDRSVFCQMEVLDRYCSIPG--- 1084
Query: 1060 VDDFYYDYNFINFHEDLSYGPSEEPDLDLAGTGDRTPPPHSHPAAPSTGSPVPATEPPAA 1119
Y+ ++ + S GP+ PD P P S P + GSP+P + PA
Sbjct: 1085 ----YHRLCCVSCIKKAS-GPNPGPD----------PGPTSLPPFSTPGSPLPGPQDPAD 1129
Query: 1120 KEEGVLGPWSPSPWPSQAGRSPPPPSEQTPGNPLINFLPEEDTPIGAPDLGLPSLSWPRV 1179
E P P+ + + Q PG L P P AP+ +P SW
Sbjct: 1130 AAE-------PPGKPTGSEDHQHGRATQLPG-ALDTSSPGTQHPF-APETPIPGASWS-- 1178
Query: 1180 STDGLQTPATPESQNDFPVGKDSQSQLPPPWRDRTNEVFKDDEEPKGRGAPHLPPRPSST 1239
+P TP LP W V +D +P G H P ++
Sbjct: 1179 -----ISPTTP-------------GGLPWGWTQTPTPVPEDKGQP-GEDLRH----PGTS 1215
Query: 1240 LPPLSPV 1246
LP SPV
Sbjct: 1216 LPAASPV 1222
Score = 104 bits (259), Expect = 8e-22
Identities = 89/282 (31%), Positives = 108/282 (38%), Gaps = 55/282 (19%)
Query: 1415 WQAGNWSECSTTCGLGAVWRPVRCSSGRDED------CAPAGRPQP-ARRCHLRPCA--T 1465
W +W+ CS CG G + C RD C RP+P RRC+ PC+
Sbjct: 851 WALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQPV 910
Query: 1466 WHSGNWSKCSRSCGG-GSSVRDVQCVDTRDLRPLRPFHCQPGPAK------PPAHRPCGA 1518
W + W CSRSCG G R +QC L PL + PAK P A RPC
Sbjct: 911 WVTEEWGACSRSCGKLGVQTRGIQC-----LLPLSNGTHKVMPAKACAGDRPEARRPCLR 965
Query: 1519 QPC-LSWYTSSWRECSEACGGGEQQRLVTC----PEPGLCEEALRPNTTRPCNTHPCTQW 1573
PC W +W +CS CG G QQR V C G C E RP+T + C+
Sbjct: 966 VPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHC-EGDRPDTVQVCSL------ 1018
Query: 1574 VVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPC-GTEDCEPVE 1632
CGG Q V+ + G PE W S P E
Sbjct: 1019 ---------PACGGNHQNSTVRADVWELGTPEGQ--------WVPQSEPLHPINKISSTE 1061
Query: 1633 PPRCERDRLSFGFCETLRLLGRCQLPTIRTQCCRSCSPPSHG 1674
P C DR FC+ L C +P CC SC + G
Sbjct: 1062 P--CTGDRSV--FCQMEVLDRYCSIPGYHRLCCVSCIKKASG 1099
Score = 40.4 bits (93), Expect = 0.015
Identities = 27/87 (31%), Positives = 36/87 (41%), Gaps = 2/87 (2%)
Query: 1385 SHRVPETQPLAPSLAEAGPPADPLVVRNAGWQAGNWSECSTTCGLGAVWRPVRCSSGRDE 1444
+H+V + A EA P V A W+ G WS+CS TCG G R V C + +
Sbjct: 943 THKVMPAKACAGDRPEARRPC-LRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANS 1001
Query: 1445 -DCAPAGRPQPARRCHLRPCATWHSGN 1470
RP + C L C H +
Sbjct: 1002 LGHCEGDRPDTVQVCSLPACGGNHQNS 1028
>gi|110825974 ADAM metallopeptidase with thrombospondin type 1 motif,
2 isoform 1 preproprotein [Homo sapiens]
Length = 1211
Score = 499 bits (1286), Expect = e-141
Identities = 342/1047 (32%), Positives = 491/1047 (46%), Gaps = 76/1047 (7%)
Query: 2 PGGPSPRSPAPLLRPLLLLLCA-LAPGAPGPA----------PGRATEGRAALDIVHPVR 50
P G + R P L LLLLL L P P PA PG A + PVR
Sbjct: 4 PAGAARRLLCPALLLLLLLLPPPLLPPPPPPANARLAAAADPPGGPLGHGAERILAVPVR 63
Query: 51 VDAGGSFLSYELWPRALRKRDVSVRRDAPA-----------------FYELQYRGRELRF 93
DA G +S+ + A + V RR AP FY + GR+L
Sbjct: 64 TDAQGRLVSHVV-SAATSRAGVRARRAAPVRTPSFPGGNEEEPGSHLFYNVTVFGRDLHL 122
Query: 94 NLTANQHLLAPGFVSETRRRGGLGRAHIRAHTPACHLLGEVQDPELEGGLAAISACDGLK 153
L N L+APG E + G G + +C +G+V E A+S CDGL
Sbjct: 123 RLRPNARLVAPGATMEWQ--GEKGTTRVEPLLGSCLYVGDVAGLA-EASSVALSNCDGLA 179
Query: 154 GVFQLSNEDYFIEPLDS--APARPGHAQPHVVYKRQAPERLAQRGDSSAPSTCGVQVYPE 211
G+ ++ E++FIEPL+ A + HVVY+R P G A T G +
Sbjct: 180 GLIRMEEEEFFIEPLEKGLAAQEAEQGRVHVVYRR--PPTSPPLGGPQALDT-GASL-DS 235
Query: 212 LESRRERWEQRQQWRRPRLRRLHQRSVSKEKWVETLVVADAKMVEYHGQPQVESYVLTIM 271
L+S ++ RR + + + +E L+ D +V++HG+ V+ Y+LT+M
Sbjct: 236 LDSLSRALGVLEEHANSSRRRARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLM 295
Query: 272 NMVAGLFHDPSIGNPIHITIVRLVLLE-DEEEDLKITHHADNTLKSFCKWQKSINMKGDA 330
N+V ++HD S+G I++ +VR++LL + L + +L++ C+W
Sbjct: 296 NIVNEIYHDESLGAHINVVLVRIILLSYGKSMSLIEIGNPSQSLENVCRWAYLQQKPDTG 355
Query: 331 HPLHHDTAILLTRKDLCAAMNRPCETLGLSHVAGMCQPHRSCSINEDTGLPLAFTVAHEL 390
H +HD AI LTR+D P G + V GMC P RSC++N + G AF VAHE
Sbjct: 356 HDEYHDHAIFLTRQDF-----GPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHET 410
Query: 391 GHSFGIQHDGSGNDCEPVGKRPFIMSPQLLYDAAPLTWSRCSRQYITRFLDRGWGLCLDD 450
GH G++HDG GN C + IM+P + WSRCS+Q ++R+L + LDD
Sbjct: 411 GHVLGMEHDGQGNRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELSRYL-HSYDCLLDD 469
Query: 451 PPAKDIIDFPSVP--PGVLYDVSHQCRLQYGAYSAFCEDMD--NVCHTLWCSVGTT---C 503
P A D+P++P PG+ Y ++ QCR +G C + C LWCS C
Sbjct: 470 PFAH---DWPALPQLPGLHYSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSHPDNPYFC 526
Query: 504 HSKLDAAVDGTRCGENKWCLSGECVPVGFRPEAV--DGGWSGWSAWSICSRSCGMGVQSA 561
+K +DGT C K C G C + P+ + DG W WS + CSR+CG GV+
Sbjct: 527 KTKKGPPLDGTMCAPGKHCFKGHC--IWLTPDILKRDGSWGAWSPFGSCSRTCGTGVKFR 584
Query: 562 ERQCTQPTPKYKGRYCVGERKRFRLCNLQACPAGRPSFRHVQCSHFDAMLYKGQL-HTWV 620
RQC P P GR C G F+LC+ Q CP FR QC +D G H W+
Sbjct: 585 TRQCDNPHPANGGRTCSGLAYDFQLCSRQDCPDSLADFREEQCRQWDLYFEHGDAQHHWL 644
Query: 621 PVV--NDVNPCELHCRPANEYFAEKLRDAVVDGTPCYQVRASRDLCINGICKNVGCDFEI 678
P + C L+C ++ V DGT C + + LC+ G C+ VGCD I
Sbjct: 645 PHEHRDAKERCHLYCESRETGEVVSMKRMVHDGTRC-SYKDAFSLCVRGDCRKVGCDGVI 703
Query: 679 DSGAMEDRCGVCHGNGSTCHTVSGTFEEA-EGLGYVDVGLIPAGAREIRIQEVAEAANFL 737
S ED+CGVC G+ S C V GTF + + GY+ + IPAGAR + IQEV ++ L
Sbjct: 704 GSSKQEDKCGVCGGDNSHCKVVKGTFTRSPKKHGYIKMFEIPAGARHLLIQEVDATSHHL 763
Query: 738 ALRSEDPEKYFLNGGWTIQWNGDYQVA-GTTFTYARRGNWENLTSPGPTKEPVWIQLL-F 795
A+++ + K+ LN + + +A G + Y E L + GP + + ++
Sbjct: 764 AVKNLETGKFILNEENDVDASSKTFIAMGVEWEYRDEDGRETLQTMGPLHGTITVLVIPV 823
Query: 796 QESNPGVHYEYTIHREAGGHD-----EVPPPVFSWHYGPWTKCTVTCGRGVQRQNVYCLE 850
++ + Y+Y IH ++ D E V+ W W+ C+ CG G Q C
Sbjct: 824 GDTRVSLTYKYMIHEDSLNVDDNNVLEEDSVVYEWALKKWSPCSKPCGGGSQFTKYGCRR 883
Query: 851 R-QAGPVDEEHCDPLGRPDDQQRKCSEQPCPAR-WWAGEWQLCSSSCGPGGLSRRAVLCI 908
R V C L +P +R C+ Q C W GEW+ CS +CG G+ R+V CI
Sbjct: 884 RLDHKMVHRGFCAALSKPKAIRRACNPQECSQPVWVTGEWEPCSQTCGRTGMQVRSVRCI 943
Query: 909 RSVGLDEQSALEPPACEHLPRPPTETPCNRHVPCPATWAVGNWSQCSVTCGEGTQRRNVL 968
+ + + ++ C RP + C+R + CP W G WSQCSVTCG GTQ R VL
Sbjct: 944 QPLHDNTTRSVHAKHCND-ARPESRRACSREL-CPGRWRAGPWSQCSVTCGNGTQERPVL 1001
Query: 969 C-TNDTGVPCDEAQQPASEVTCSLPLC 994
C T D + ++P + TC L C
Sbjct: 1002 CRTADDSFGICQEERPETARTCRLGPC 1028
Score = 99.0 bits (245), Expect = 3e-20
Identities = 73/246 (29%), Positives = 91/246 (36%), Gaps = 51/246 (20%)
Query: 1466 WHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAHRPCGAQPCLS-- 1523
W WS CS+ CGGGS C D + + C R C Q C
Sbjct: 858 WALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQPV 917
Query: 1524 WYTSSWRECSEACGG-GEQQRLVTCPEP-----------GLCEEALRPNTTRPCNTHPCT 1571
W T W CS+ CG G Q R V C +P C +A RP + R C+ C
Sbjct: 918 WVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDA-RPESRRACSRELCP 976
Query: 1572 -QWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPCGTEDC-- 1628
+W GPW QCS CG G Q R V C +DS E PE++R C C
Sbjct: 977 GRWRAGPWSQCSVTCGNGTQERPVLCRTA------DDSFGICQEERPETARTCRLGPCPR 1030
Query: 1629 ------------------EPVEPPR-------CERDRLSFGFCETLRLLGRCQLPTIRTQ 1663
+P P R C+ D+ FC L C +P
Sbjct: 1031 NISDPSKKSYVVQWLSRPDPDSPIRKISSKGHCQGDKSI--FCRMEVLSRYCSIPGYNKL 1088
Query: 1664 CCRSCS 1669
CC+SC+
Sbjct: 1089 CCKSCN 1094
Score = 98.2 bits (243), Expect = 6e-20
Identities = 59/181 (32%), Positives = 81/181 (44%), Gaps = 21/181 (11%)
Query: 1415 WQAGNWSECSTTCGLGAVWRPVRCSSGRDED------CAPAGRPQPARR-CHLRPCA--T 1465
W WS CS CG G+ + C D CA +P+ RR C+ + C+
Sbjct: 858 WALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQPV 917
Query: 1466 WHSGNWSKCSRSCG-GGSSVRDVQCVD---TRDLRPLRPFHCQPGPAKPPAHRPCGAQPC 1521
W +G W CS++CG G VR V+C+ R + HC A+P + R C + C
Sbjct: 918 WVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHC--NDARPESRRACSRELC 975
Query: 1522 LS-WYTSSWRECSEACGGGEQQRLVTCPEP----GLCEEALRPNTTRPCNTHPCTQWVVG 1576
W W +CS CG G Q+R V C G+C+E RP T R C PC + +
Sbjct: 976 PGRWRAGPWSQCSVTCGNGTQERPVLCRTADDSFGICQEE-RPETARTCRLGPCPRNISD 1034
Query: 1577 P 1577
P
Sbjct: 1035 P 1035
Score = 31.6 bits (70), Expect = 6.8
Identities = 29/117 (24%), Positives = 44/117 (37%), Gaps = 11/117 (9%)
Query: 1572 QWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPES-SRPCGTEDC-E 1629
+W + W CS PCGGG Q C + C + P++ R C ++C +
Sbjct: 857 EWALKKWSPCSKPCGGGSQFTKYGC-RRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQ 915
Query: 1630 PV------EP--PRCERDRLSFGFCETLRLLGRCQLPTIRTQCCRSCSPPSHGAPSR 1678
PV EP C R + ++ L ++ + C P S A SR
Sbjct: 916 PVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDARPESRRACSR 972
>gi|21265037 ADAM metallopeptidase with thrombospondin type 1 motif, 3
proprotein [Homo sapiens]
Length = 1205
Score = 497 bits (1280), Expect = e-140
Identities = 328/1009 (32%), Positives = 469/1009 (46%), Gaps = 94/1009 (9%)
Query: 44 DIVHPVRVDAGGSFLSYELWPRALRK--RDVSVRRDAPAFYELQYRGRELRFNLTANQHL 101
++V PV + G +LS+ L ++ RDVS + F+ + G++ L N L
Sbjct: 43 ELVTPVSTNLEGRYLSHTLSASHKKRSARDVSSNPEQ-LFFNITAFGKDFHLRLKPNTQL 101
Query: 102 LAPGFVSE---------------TRRRGGLGRAHIRAHTPA---CHLLGEVQDPELEGGL 143
+APG V E + G IR P C +G++ D + G
Sbjct: 102 VAPGAVVEWHETSLVPGNITDPINNHQPGSATYRIRKTEPLQTNCAYVGDIVD--IPGTS 159
Query: 144 AAISACDGLKGVFQLSNEDYFIEPLDSAPARPGH-AQPHVVYKRQAPERLA--------- 193
AIS CDGL G+ + NE+YFIEPL+ + HVVYKR A E+
Sbjct: 160 VAISNCDGLAGMIKSDNEEYFIEPLERGKQMEEEKGRIHVVYKRSAVEQAPIDMSKDFHY 219
Query: 194 QRGDSSAPSTCGVQVYPELESRRERWEQRQQWRRPRLRRLHQRSVSKEKWVETLVVADAK 253
+ D G VY + QQ RR H + + +E L+ D
Sbjct: 220 RESDLEGLDDLGT-VYGNIH---------QQLNETMRRRRH--AGENDYNIEVLLGVDDS 267
Query: 254 MVEYHGQPQVESYVLTIMNMVAGLFHDPSIGNPIHITIVRLVLLEDEEEDLKITH-HADN 312
+V +HG+ V++Y+LT+MN+V ++HD S+G I++ +VR+++L + I +
Sbjct: 268 VVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVHINVVLVRMIMLGYAKSISLIERGNPSR 327
Query: 313 TLKSFCKWQKSINMKGDAHPLHHDTAILLTRKDLCAAMNRPCETLGLSHVAGMCQPHRSC 372
+L++ C+W H HHD AI LTR+D P G + V GMC P RSC
Sbjct: 328 SLENVCRWASQQQRSDLNHSEHHDHAIFLTRQDF-----GPAGMQGYAPVTGMCHPVRSC 382
Query: 373 SINEDTGLPLAFTVAHELGHSFGIQHDGSGNDCEPVGKRPFIMSPQLLYDAAPLTWSRCS 432
++N + G AF VAHE GH G++HDG GN C +M+P + WSRCS
Sbjct: 383 TLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDETAMGSVMAPLVQAAFHRYHWSRCS 442
Query: 433 RQYITRFLDRGWGLCLDDPPAKDIIDFPSVPPGVLYDVSHQCRLQYGAYSAFCEDMDNV- 491
Q + R++ + LDDP D P +P G+ Y + QCR +G C
Sbjct: 443 GQELKRYI-HSYDCLLDDPFDHDWPKLPELP-GINYSMDEQCRFDFGVGYKMCTAFRTFD 500
Query: 492 -CHTLWCSVGTT---CHSKLDAAVDGTRCGENKWCLSGECVPVGFRPEAVDGGWSGWSAW 547
C LWCS C +K +DGT C KWC G C+ + DG W W+ +
Sbjct: 501 PCKQLWCSHPDNPYFCKTKKGPPLDGTECAAGKWCYKGHCMWKNANQQKQDGNWGSWTKF 560
Query: 548 SICSRSCGMGVQSAERQCTQPTPKYKGRYCVGERKRFRLCNLQACPAGRPSFRHVQC--- 604
CSR+CG GV+ RQC P P G+ C G ++LCN + C FR QC
Sbjct: 561 GSCSRTCGTGVRFRTRQCNNPMPINGGQDCPGVNFEYQLCNTEECQKHFEDFRAQQCQQR 620
Query: 605 -SHFDAMLYKGQLHTWVPV--VNDVNPCELHCRPANEYFAEKLRDAVVDGTPCYQVRASR 661
SHF+ Y+ H W+P + C L+C+ ++ V DGT C +
Sbjct: 621 NSHFE---YQNTKHHWLPYEHPDPKKRCHLYCQSKETGDVAYMKQLVHDGTHC-SYKDPY 676
Query: 662 DLCINGICKNVGCDFEIDSGAMEDRCGVCHGNGSTCHTVSGTFEEA-EGLGYVDVGLIPA 720
+C+ G C VGCD EI S +ED+CGVC G+ S C TV GTF LGY+ + IP
Sbjct: 677 SICVRGECVKVGCDKEIGSNKVEDKCGVCGGDNSHCRTVKGTFTRTPRKLGYLKMFDIPP 736
Query: 721 GAREIRIQEVAEAANFLALRSEDPEKYFLNGGWTIQWNGDYQVAGTTFTYARRGNWENLT 780
GAR + IQE + + LA++++ Y LNG + + G + Y + E+L
Sbjct: 737 GARHVLIQEDEASPHILAIKNQATGHYILNGKGEEAKSRTFIDLGVEWDYNIEDDIESLH 796
Query: 781 SPGPTKEPVWIQLLFQESN--PGVHYEYTIHREAGGHDEVPP-----------PVFSWHY 827
+ GP +PV + ++ QE++ + Y+Y IH D VP F W
Sbjct: 797 TDGPLHDPVIVLIIPQENDTRSSLTYKYIIH-----EDSVPTINSNNVIQEELDTFEWAL 851
Query: 828 GPWTKCTVTCGRGVQRQNVYCLERQAGP-VDEEHCDPLGRPDDQQRKCSEQPCP-ARWWA 885
W++C+ CG G Q C + V C+ +P +R C+ Q C W A
Sbjct: 852 KSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHPLWVA 911
Query: 886 GEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPCNRHVPCPAT 945
EW+ C+ +CG G R V C++ + ++ C RP + PCNR VPCPA
Sbjct: 912 EEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMG-DRPESRRPCNR-VPCPAQ 969
Query: 946 WAVGNWSQCSVTCGEGTQRRNVLCTNDTGVPCDEAQQPASEVTCSLPLC 994
W G WS+CSVTCGEGT+ R VLC G CD ++P S C LP C
Sbjct: 970 WKTGPWSECSVTCGEGTEVRQVLCR--AGDHCD-GEKPESVRACQLPPC 1015
Score = 114 bits (284), Expect = 1e-24
Identities = 76/226 (33%), Positives = 91/226 (40%), Gaps = 31/226 (13%)
Query: 1466 WHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAHRPCGAQPCLS-- 1523
W +WS+CS+ CGGG C D + + C+ P R C Q C
Sbjct: 849 WALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHPL 908
Query: 1524 WYTSSWRECSEACG-GGEQQRLVTCPEPGL-----------CEEALRPNTTRPCNTHPC- 1570
W W C++ CG G Q R V C +P L C RP + RPCN PC
Sbjct: 909 WVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYC-MGDRPESRRPCNRVPCP 967
Query: 1571 TQWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPCGTEDCEP 1630
QW GPW +CS CG G + R V C D C E PES R C C
Sbjct: 968 AQWKTGPWSECSVTCGEGTEVRQVLC---------RAGDHCDGEK-PESVRACQLPPCND 1017
Query: 1631 VEPPRCERDRLSFGFCETLRLLGRCQLPTIRTQCCRSCSPPSHGAP 1676
EP C D+ FC+ L C +P CC SCS S P
Sbjct: 1018 -EP--CLGDKSI--FCQMEVLARYCSIPGYNKLCCESCSKRSSTLP 1058
Score = 90.9 bits (224), Expect = 9e-18
Identities = 54/174 (31%), Positives = 77/174 (44%), Gaps = 20/174 (11%)
Query: 1415 WQAGNWSECSTTCGLGAVWRPVRCSSGRDED------CAPAGRPQPARR-CHLRPCA--T 1465
W +WS+CS CG G + C D C +P+P RR C+++ C
Sbjct: 849 WALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHPL 908
Query: 1466 WHSGNWSKCSRSCG-GGSSVRDVQCVD---TRDLRPLRPFHCQPGPAKPPAHRPCGAQPC 1521
W + W C+++CG G +R V+C+ R + +C +P + RPC PC
Sbjct: 909 WVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGD--RPESRRPCNRVPC 966
Query: 1522 -LSWYTSSWRECSEACGGGEQQRLVTCPEPGLCE----EALRPNTTRPCNTHPC 1570
W T W ECS CG G + R V C C+ E++R PCN PC
Sbjct: 967 PAQWKTGPWSECSVTCGEGTEVRQVLCRAGDHCDGEKPESVRACQLPPCNDEPC 1020
Score = 62.4 bits (150), Expect = 4e-09
Identities = 42/122 (34%), Positives = 53/122 (43%), Gaps = 23/122 (18%)
Query: 1415 WQAGNWSECSTTCGL-GAVWRPVRC---------SSGRDEDCAPAGRPQPARRCHLRPC- 1463
W A W C+ TCG G R VRC S + C RP+ R C+ PC
Sbjct: 909 WVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCM-GDRPESRRPCNRVPCP 967
Query: 1464 ATWHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHC---QPGPAKPPAHRPCGAQP 1520
A W +G WS+CS +CG G+ VR V C HC +P + PC +P
Sbjct: 968 AQWKTGPWSECSVTCGEGTEVRQVLC--------RAGDHCDGEKPESVRACQLPPCNDEP 1019
Query: 1521 CL 1522
CL
Sbjct: 1020 CL 1021
Score = 49.7 bits (117), Expect = 2e-05
Identities = 23/51 (45%), Positives = 27/51 (52%), Gaps = 3/51 (5%)
Query: 1413 AGWQAGNWSECSTTCGLGAVWRPVRCSSGRDEDCAPAGRPQPARRCHLRPC 1463
A W+ G WSECS TCG G R V C +G D +P+ R C L PC
Sbjct: 968 AQWKTGPWSECSVTCGEGTEVRQVLCRAG---DHCDGEKPESVRACQLPPC 1015
Score = 36.2 bits (82), Expect = 0.28
Identities = 18/64 (28%), Positives = 30/64 (46%), Gaps = 14/64 (21%)
Query: 1572 QWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESS-------RPCG 1624
+W + W QCS PCGGG Q T+ G + ++ H ++ E++ R C
Sbjct: 848 EWALKSWSQCSKPCGGGFQ-------YTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCN 900
Query: 1625 TEDC 1628
++C
Sbjct: 901 IQEC 904
>gi|21265058 a disintegrin-like and metalloprotease (reprolysin
type) with thrombospondin type 1 motif, 15 preproprotein
[Homo sapiens]
Length = 950
Score = 488 bits (1255), Expect = e-137
Identities = 363/1001 (36%), Positives = 477/1001 (47%), Gaps = 120/1001 (11%)
Query: 18 LLLLCALAPGAPGPAPGRATEGRAALDIVHPVRVDAGGSFLSYELWPRALRKRDVSVRRD 77
+LLL L G G + R ++V P+R+D + Y W D +
Sbjct: 1 MLLLGILTLAFAGRTAGGSEPER---EVVVPIRLDPDINGRRY-YWRGPEDSGDQGLIFQ 56
Query: 78 APAFYELQYRGRELRFNLTANQHLLAPGFVSETRRRGGLGRAHIRAHTPACHLLGEVQ-D 136
AF E Y +LT + LAP F +E G + C G+V +
Sbjct: 57 ITAFQEDFY------LHLTPDAQFLAPAFSTEHLGVPLQGLTGGSSDLRRCFYSGDVNAE 110
Query: 137 PELEGGLAAISACDGLKGVFQLSNEDYFIEPLD--SAPARPGHAQ-PHVVYKRQAPERLA 193
P+ AA+S C GL+G F +Y I PL SAPA ++Q H++ +R P
Sbjct: 111 PD---SFAAVSLCGGLRGAFGYRGAEYVISPLPNASAPAAQRNSQGAHLLQRRGVPG--- 164
Query: 194 QRGDSSAP-STCGVQ----------VYPELESRRERWEQRQQWRRPRLRRLHQRSVSKEK 242
G S P S CGV + P R E R + R R +R VS +
Sbjct: 165 --GPSGDPTSRCGVASGWNPAILRALDPYKPRRAGFGESRSRRRSGRAKRF----VSIPR 218
Query: 243 WVETLVVADAKMVEYHGQPQVESYVLTIMNMVAGLFHDPSIGNPIHITIVRLVLLEDEEE 302
+VETLVVAD MV++HG +E Y+LT++ A L+ PSI NPI+I +V+++LL D +
Sbjct: 219 YVETLVVADESMVKFHGA-DLEHYLLTLLATAARLYRHPSILNPINIVVVKVLLLRDRDS 277
Query: 303 DLKITHHADNTLKSFCKWQKSINMKGDAHPLHHDTAILLTRKDLCAAMNRPCETLGLSHV 362
K+T +A TL++FC WQK +N D HP + DTAIL TR+DLC A C+TLG++ V
Sbjct: 278 GPKVTGNAALTLRNFCAWQKKLNKVSDKHPEYWDTAILFTRQDLCGATT--CDTLGMADV 335
Query: 363 AGMCQPHRSCSINEDTGLPLAFTVAHELGHSFGIQHDGSGNDCEPVGK--RPFIMSPQLL 420
MC P RSCS+ ED GLP AFT AHELGH F + HD E GK +MSP L+
Sbjct: 336 GTMCDPKRSCSVIEDDGLPSAFTTAHELGHVFNMPHDNVKVCEEVFGKLRANHMMSPTLI 395
Query: 421 YDAAPLTWSRCSRQYITRFLDRGWGLCLDDPPAKDIIDFPSVPPGVLYDVSHQCRLQYGA 480
WS CS IT FLD G G CL D P+K I P PG Y +S QC L +G
Sbjct: 396 QIDRANPWSACSAAIITDFLDSGHGDCLLDQPSKPI-SLPEDLPGASYTLSQQCELAFGV 454
Query: 481 YSAFCEDMDNVCHTLWCSVGT----TCHSKLDAAVDGTRCGENKWCLSGECVPV-GFRPE 535
S C M C LWC+ C ++ DGT CGE K CL G CV
Sbjct: 455 GSKPCPYMQ-YCTKLWCTGKAKGQMVCQTRHFPWADGTSCGEGKLCLKGACVERHNLNKH 513
Query: 536 AVDGGWSGWSAWSICSRSCGMGVQSAERQCTQPTPKYKGRYCVGERKRFRLCNLQACP-- 593
VDG W+ W + CSR+CG GVQ A RQCT PTP G+YC G R ++R CNL+ CP
Sbjct: 514 RVDGSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGVRVKYRSCNLEPCPSS 573
Query: 594 AGRPSFRHVQCSHFDAMLYKGQLHT----WVPVVNDVNP---CELHCRPANEYFAEKLRD 646
A SFR QC F+ + T WVP + V+P C+L CR + L
Sbjct: 574 ASGKSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSPRDKCKLICRANGTGYFYVLAP 633
Query: 647 AVVDGTPCYQVRASRDLCINGICKNVGCDFEIDSGAMEDRCGVCHGNGSTCHTVSGTFEE 706
VVDGT C S +C+ G C GCD + S D+CGVC G+ +C V+G F +
Sbjct: 634 KVVDGTLCSP--DSTSVCVQGKCIKAGCDGNLGSKKRFDKCGVCGGDNKSCKKVTGLFTK 691
Query: 707 AEGLGYVDVGLIPAGAREIRIQEVAEAA-----NFLALRSEDPEKYFLNGGWTIQW-NGD 760
GY V IPAGA I I++ N+LAL++ KY LNG + + D
Sbjct: 692 PMH-GYNFVVAIPAGASSIDIRQRGYKGLIGDDNYLALKNSQG-KYLLNGHFVVSAVERD 749
Query: 761 YQVAGTTFTYARRGNW-ENLTSPGPTKEPVWIQLLF--QESNPGVHYEYTIHREA----G 813
V G+ Y+ G E+L + P EP+ +++L + + P V Y + + +E
Sbjct: 750 LVVKGSLLRYSGTGTAVESLQASRPILEPLTVEVLSVGKMTPPRVRYSFYLPKEPREDKS 809
Query: 814 GHDEVPPPVFSWHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRK 873
H + P G V +V L Q + +PDD+
Sbjct: 810 SHPKDPR-----------------GPSVLHNSVLSLSNQ-----------VEQPDDRP-- 839
Query: 874 CSEQPCPARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTE 933
PARW AG W CS+SCG GL +RAV C S G PAC+ RP
Sbjct: 840 ------PARWVAGSWGPCSASCG-SGLQKRAVDCRGSAG-----QRTVPACDAAHRPVET 887
Query: 934 TPCNRHVPCPATWAVGNWSQCSVTCGEGTQRRNVLCTNDTG 974
C PCP TW + WS CS +CG G QRR++ C G
Sbjct: 888 QACGE--PCP-TWELSAWSPCSKSCGRGFQRRSLKCVGHGG 925
Score = 72.0 bits (175), Expect = 5e-12
Identities = 41/116 (35%), Positives = 49/116 (42%), Gaps = 9/116 (7%)
Query: 1519 QPCLSWYTSSWRECSEACGGGEQQRLVTCPEPG------LCEEALRPNTTRPCNTHPCTQ 1572
+P W SW CS +CG G Q+R V C C+ A RP T+ C PC
Sbjct: 838 RPPARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQACG-EPCPT 896
Query: 1573 WVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPCGTEDC 1628
W + W CS CG G QRR +KCV L DQC P+ C C
Sbjct: 897 WELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLAR--DQCNLHRKPQELDFCVLRPC 950
Score = 71.6 bits (174), Expect = 6e-12
Identities = 43/122 (35%), Positives = 55/122 (45%), Gaps = 21/122 (17%)
Query: 1461 RPCATWHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAHRP----- 1515
RP A W +G+W CS SCG G R V C + R + PA AHRP
Sbjct: 838 RPPARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTV--------PACDAAHRPVETQA 889
Query: 1516 CGAQPCLSWYTSSWRECSEACGGGEQQRLVTCPEPG-------LCEEALRPNTTRPCNTH 1568
CG +PC +W S+W CS++CG G Q+R + C G C +P C
Sbjct: 890 CG-EPCPTWELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFCVLR 948
Query: 1569 PC 1570
PC
Sbjct: 949 PC 950
Score = 67.0 bits (162), Expect = 1e-10
Identities = 33/82 (40%), Positives = 40/82 (48%), Gaps = 5/82 (6%)
Query: 1413 AGWQAGNWSECSTTCGLGAVWRPVRCSSGRDEDCAPA----GRPQPARRCHLRPCATWHS 1468
A W AG+W CS +CG G R V C + PA RP + C PC TW
Sbjct: 841 ARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQACG-EPCPTWEL 899
Query: 1469 GNWSKCSRSCGGGSSVRDVQCV 1490
WS CS+SCG G R ++CV
Sbjct: 900 SAWSPCSKSCGRGFQRRSLKCV 921
Score = 55.5 bits (132), Expect = 4e-07
Identities = 27/71 (38%), Positives = 31/71 (43%), Gaps = 4/71 (5%)
Query: 943 PATWAVGNWSQCSVTCGEGTQRRNVLCTNDTG---VP-CDEAQQPASEVTCSLPLCRWPL 998
PA W G+W CS +CG G Q+R V C G VP CD A +P C P W L
Sbjct: 840 PARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQACGEPCPTWEL 899
Query: 999 GTLGPEGSGSG 1009
P G
Sbjct: 900 SAWSPCSKSCG 910
Score = 45.4 bits (106), Expect = 5e-04
Identities = 26/81 (32%), Positives = 34/81 (41%), Gaps = 16/81 (19%)
Query: 1560 NTTRPCNTHPCTQWVVGPWGQCSGPCGGGVQRRLVKCVNT--QTGLPEED-------SDQ 1610
N + P +WV G WG CS CG G+Q+R V C + Q +P D +
Sbjct: 830 NQVEQPDDRPPARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQA 889
Query: 1611 CGH-------EAWPESSRPCG 1624
CG AW S+ CG
Sbjct: 890 CGEPCPTWELSAWSPCSKSCG 910
Score = 38.9 bits (89), Expect = 0.043
Identities = 17/59 (28%), Positives = 30/59 (50%), Gaps = 1/59 (1%)
Query: 821 PVFSWHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQPC 879
P +W W+ C+ +CGRG QR+++ C+ + + C+ L R + C +PC
Sbjct: 893 PCPTWELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCN-LHRKPQELDFCVLRPC 950
Score = 33.1 bits (74), Expect = 2.3
Identities = 34/129 (26%), Positives = 47/129 (36%), Gaps = 30/129 (23%)
Query: 1517 GAQPC--LSWYTSSWRECSEACGGGEQQRLV------------TCPEPGLCEEAL---RP 1559
G++PC + + T W C G + ++V +C E LC + R
Sbjct: 455 GSKPCPYMQYCTKLW------CTGKAKGQMVCQTRHFPWADGTSCGEGKLCLKGACVERH 508
Query: 1560 NTTRPCNTHPCTQWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPES 1619
N + +W P+G CS CGGGVQ +C N P C E
Sbjct: 509 NLNKHRVDGSWAKW--DPYGPCSRTCGGGVQLARRQCTNP---TPANGGKYC--EGVRVK 561
Query: 1620 SRPCGTEDC 1628
R C E C
Sbjct: 562 YRSCNLEPC 570
Score = 31.6 bits (70), Expect = 6.8
Identities = 19/61 (31%), Positives = 29/61 (47%), Gaps = 11/61 (18%)
Query: 1469 GNWSK------CSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAHRPCGAQPCL 1522
G+W+K CSR+CGGG + QC + + +C+ K +R C +PC
Sbjct: 517 GSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGK--YCEGVRVK---YRSCNLEPCP 571
Query: 1523 S 1523
S
Sbjct: 572 S 572
>gi|50845384 ADAM metallopeptidase with thrombospondin type 1 motif,
1 preproprotein [Homo sapiens]
Length = 967
Score = 480 bits (1235), Expect = e-135
Identities = 317/896 (35%), Positives = 447/896 (49%), Gaps = 78/896 (8%)
Query: 89 RELRFNLTANQHLLAPGF-VSETRRRGGLGRAHIRAHTPACHLLGEVQ-DPELEGGLAAI 146
++L L + LAPGF + R+ G C G V DP AA+
Sbjct: 83 QQLDLELRPDSSFLAPGFTLQNVGRKSGSETPLPETDLAHCFYSGTVNGDPS---SAAAL 139
Query: 147 SACDGLKGVFQLSNEDYFIEPLDSAPARPGHAQPHVVYKRQAPER---LAQRGDSSAPST 203
S C+G++G F L E YFI+PL +A R A P K AP + L + T
Sbjct: 140 SLCEGVRGAFYLLGEAYFIQPLPAASERLATAAPGE--KPPAPLQFHLLRRNRQGDVGGT 197
Query: 204 CGV---QVYP----ELESRRERWE---QRQQW--RRPRLRRLHQ----------RSVSKE 241
CGV + P E E E E + QW + P L+ + Q R VS
Sbjct: 198 CGVVDDEPRPTGKAETEDEDEGTEGEDEGAQWSPQDPALQGVGQPTGTGSIRKKRFVSSH 257
Query: 242 KWVETLVVADAKMVEYHGQPQVESYVLTIMNMVAGLFHDPSIGNPIHITIVRLVLLEDEE 301
++VET++VAD M E+HG ++ Y+LT+ ++ A L+ PSI N + + +V+++++ DE+
Sbjct: 258 RYVETMLVADQSMAEFHGSG-LKHYLLTLFSVAARLYKHPSIRNSVSLVVVKILVIHDEQ 316
Query: 302 EDLKITHHADNTLKSFCKWQKSINMKGDAHPLHHDTAILLTRKDLCAAMNRPCETLGLSH 361
+ ++T +A TL++FC WQK N D H+DTAIL TR+DLC ++ C+TLG++
Sbjct: 317 KGPEVTSNAALTLRNFCNWQKQHNPPSDRDAEHYDTAILFTRQDLCG--SQTCDTLGMAD 374
Query: 362 VAGMCQPHRSCSINEDTGLPLAFTVAHELGHSFGIQHDGSGN--DCEPVGKRPFIMSPQL 419
V +C P RSCS+ ED GL AFT AHELGH F + HD + V + +M+ L
Sbjct: 375 VGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHDDAKQCASLNGVNQDSHMMASML 434
Query: 420 LYDAAPLTWSRCSRQYITRFLDRGWGLCLDDPPAKDIIDFPSVPPGVLYDVSHQCRLQYG 479
WS CS IT FLD G G CL D P ++ I P PG YD + QC+ +G
Sbjct: 435 SNLDHSQPWSPCSAYMITSFLDNGHGECLMDKP-QNPIQLPGDLPGTSYDANRQCQFTFG 493
Query: 480 AYSAFCEDMDNVCHTLWCSVGTT-----CHSKLDAAVDGTRCGENKWCLSGECVPVGFRP 534
S C D + C TLWC+ GT+ C +K DGT CGE KWC++G+CV R
Sbjct: 494 EDSKHCPDAASTCSTLWCT-GTSGGVLVCQTKHFPWADGTSCGEGKWCINGKCVNKTDRK 552
Query: 535 E---AVDGGWSGWSAWSICSRSCGMGVQSAERQCTQPTPKYKGRYCVGERKRFRLCNLQA 591
G W W W CSR+CG GVQ R+C P PK G+YC G+R R+R CNL+
Sbjct: 553 HFDTPFHGSWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVRYRSCNLED 612
Query: 592 CPAGR-PSFRHVQCSHFD----AMLYKGQLHTWVPVVNDVNP---CELHCRPANEYFAEK 643
CP +FR QC + A G W+P V+P C+L C+ +
Sbjct: 613 CPDNNGKTFREEQCEAHNEFSKASFGSGPAVEWIPKYAGVSPKDRCKLICQAKGIGYFFV 672
Query: 644 LRDAVVDGTPCYQVRASRDLCINGICKNVGCDFEIDSGAMEDRCGVCHGNGSTCHTVSGT 703
L+ VVDGTPC S +C+ G C GCD IDS D+CGVC GNGSTC +SG+
Sbjct: 673 LQPKVVDGTPCSP--DSTSVCVQGQCVKAGCDRIIDSKKKFDKCGVCGGNGSTCKKISGS 730
Query: 704 FEEAEGLGYVDVGLIPAGAREIRIQEVAEA-----ANFLALRSEDPEKYFLNGGWTIQ-W 757
A+ GY D+ IP GA I +++ + +FLA+++ D Y LNG +T+
Sbjct: 731 VTSAKP-GYHDIITIPTGATNIEVKQRNQRGSRNNGSFLAIKAAD-GTYILNGDYTLSTL 788
Query: 758 NGDYQVAGTTFTYA-RRGNWENLTSPGPTKEPVWIQLLF--QESNPGVHYEYTIHREAGG 814
D G Y+ E + S P KEP+ IQ+L P + Y Y + ++
Sbjct: 789 EQDIMYKGVVLRYSGSSAALERIRSFSPLKEPLTIQVLTVGNALRPKIKYTYFVKKKKES 848
Query: 815 HDEVPPPVFSWHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKC 874
+ + P +W W +C+ +C G QR+ V C + P E C +P R C
Sbjct: 849 FNAI-PTFSAWVIEEWGECSKSCELGWQRRLVECRDINGQPASE--CAKEVKP-ASTRPC 904
Query: 875 SEQPCPARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRP 930
++ PCP +W GEW CS +CG G +R++ C+ G L +C+ L +P
Sbjct: 905 ADHPCP-QWQLGEWSSCSKTCGK-GYKKRSLKCLSHDG----GVLSHESCDPLKKP 954
Score = 82.8 bits (203), Expect = 3e-15
Identities = 35/91 (38%), Positives = 52/91 (57%), Gaps = 5/91 (5%)
Query: 1523 SWYTSSWRECSEACGGGEQQRLVTCPE-----PGLCEEALRPNTTRPCNTHPCTQWVVGP 1577
+W W ECS++C G Q+RLV C + C + ++P +TRPC HPC QW +G
Sbjct: 857 AWVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEVKPASTRPCADHPCPQWQLGE 916
Query: 1578 WGQCSGPCGGGVQRRLVKCVNTQTGLPEEDS 1608
W CS CG G ++R +KC++ G+ +S
Sbjct: 917 WSSCSKTCGKGYKKRSLKCLSHDGGVLSHES 947
Score = 66.6 bits (161), Expect = 2e-10
Identities = 36/104 (34%), Positives = 47/104 (45%), Gaps = 6/104 (5%)
Query: 1413 AGWQAGNWSECSTTCGLGAVWRPVRCSSGRDE---DCAPAGRPQPARRCHLRPCATWHSG 1469
+ W W ECS +C LG R V C + +CA +P R C PC W G
Sbjct: 856 SAWVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEVKPASTRPCADHPCPQWQLG 915
Query: 1470 NWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAH 1513
WS CS++CG G R ++C+ + D L C P K P H
Sbjct: 916 EWSSCSKTCGKGYKKRSLKCL-SHDGGVLSHESCD--PLKKPKH 956
Score = 63.9 bits (154), Expect = 1e-09
Identities = 44/123 (35%), Positives = 62/123 (50%), Gaps = 15/123 (12%)
Query: 878 PCPARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPCN 937
P + W EW CS SC G RR V C ++ Q A E C +P + PC
Sbjct: 853 PTFSAWVIEEWGECSKSCELGW-QRRLVECR---DINGQPASE---CAKEVKPASTRPCA 905
Query: 938 RHVPCPATWAVGNWSQCSVTCGEGTQRRNVLC-TNDTGV----PCDEAQQPASEVT-CSL 991
H PCP W +G WS CS TCG+G ++R++ C ++D GV CD ++P + C++
Sbjct: 906 DH-PCPQ-WQLGEWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKPKHFIDFCTM 963
Query: 992 PLC 994
C
Sbjct: 964 AEC 966
Score = 60.5 bits (145), Expect = 1e-08
Identities = 29/84 (34%), Positives = 39/84 (46%), Gaps = 4/84 (4%)
Query: 1464 ATWHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAHRPCGAQPCLS 1523
+ W W +CS+SC G R V+C RD+ C KP + RPC PC
Sbjct: 856 SAWVIEEWGECSKSCELGWQRRLVEC---RDINGQPASECAK-EVKPASTRPCADHPCPQ 911
Query: 1524 WYTSSWRECSEACGGGEQQRLVTC 1547
W W CS+ CG G ++R + C
Sbjct: 912 WQLGEWSSCSKTCGKGYKKRSLKC 935
Score = 49.7 bits (117), Expect = 2e-05
Identities = 24/56 (42%), Positives = 31/56 (55%), Gaps = 4/56 (7%)
Query: 1573 WVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPCGTEDC 1628
WV+ WG+CS C G QRRLV+C + G P + +C E P S+RPC C
Sbjct: 858 WVIEEWGECSKSCELGWQRRLVECRDIN-GQP---ASECAKEVKPASTRPCADHPC 909
Score = 43.9 bits (102), Expect = 0.001
Identities = 23/64 (35%), Positives = 33/64 (51%), Gaps = 4/64 (6%)
Query: 940 VPCPATWAVGNWSQCSVTCGEGTQRRNVLCTNDTGVP---CDEAQQPASEVTCS-LPLCR 995
+P + W + W +CS +C G QRR V C + G P C + +PAS C+ P +
Sbjct: 852 IPTFSAWVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEVKPASTRPCADHPCPQ 911
Query: 996 WPLG 999
W LG
Sbjct: 912 WQLG 915
Score = 42.7 bits (99), Expect = 0.003
Identities = 22/53 (41%), Positives = 26/53 (49%), Gaps = 5/53 (9%)
Query: 1576 GPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPCGTEDC 1628
GPWG CS CGGGVQ + +C N +P+ C E R C EDC
Sbjct: 566 GPWGDCSRTCGGGVQYTMRECDNP---VPKNGGKYC--EGKRVRYRSCNLEDC 613
Score = 33.1 bits (74), Expect = 2.3
Identities = 22/75 (29%), Positives = 28/75 (37%), Gaps = 19/75 (25%)
Query: 1477 SCGGGSSVRDVQCVDTRDLRPL-RPFHCQPGPAKPPAHRPCGAQPCLSWYTSSWRECSEA 1535
SCG G + +CV+ D + PFH G P W +CS
Sbjct: 533 SCGEGKWCINGKCVNKTDRKHFDTPFHGSWGMWGP------------------WGDCSRT 574
Query: 1536 CGGGEQQRLVTCPEP 1550
CGGG Q + C P
Sbjct: 575 CGGGVQYTMRECDNP 589
>gi|153792351 ADAM metallopeptidase with thrombospondin type 1
motif, 8 preproprotein [Homo sapiens]
Length = 889
Score = 452 bits (1164), Expect = e-127
Identities = 320/929 (34%), Positives = 453/929 (48%), Gaps = 98/929 (10%)
Query: 7 PRSPAPLLRPLLLLLCALAPGAPGPAPGRATEGRAALDIVHPVRVDAGGSFLSYELWPRA 66
P AP PLLLLL L P A G AP R G A ++V P R+ L+ L
Sbjct: 3 PAPAAPRWPPLLLLLLLLLPLARG-APARPAAGGQASELVVPTRLPGSAGELALHL---- 57
Query: 67 LRKRDVSVRRDAPAFYELQYRGRELRFNLTANQHLLAPGFVSETRRRGGLGRAHIRAH-T 125
AF G+ L + LAP F E R GG GRA
Sbjct: 58 ------------SAF------GKGFVLRLAPDDSFLAPEFKIE--RLGGSGRATGGERGL 97
Query: 126 PACHLLGEVQ-DPELEGGLAAISACDGLKGVFQLSNEDYFIEPLDSAPARPGHAQPHVVY 184
C G V +PE LAA+S C GL G F L E++ I+P + + AQPH +
Sbjct: 98 RGCFFSGTVNGEPE---SLAAVSLCRGLSGSFLLDGEEFTIQPQGAGGSL---AQPHRLQ 151
Query: 185 K---------RQAPERLAQRGDSSAPSTCGVQVYPELESRRERWEQRQQWRRPR-LRRLH 234
+ + PE + G+ Q E ES+ E E + P
Sbjct: 152 RWGPAGARPLPRGPEWEVETGEGQRQERGDHQEDSEEESQEEEAEGASEPPPPLGATSRT 211
Query: 235 QRSVSKEKWVETLVVADAKMVEYHGQPQVESYVLTIMNMVAGLFHDPSIGNPIHITIVRL 294
+R VS+ ++VETL+VADA M ++G +++++LT+M++ A ++ PSI N I++ +V++
Sbjct: 212 KRFVSEARFVETLLVADASMAAFYGA-DLQNHILTLMSVAARIYKHPSIKNSINLMVVKV 270
Query: 295 VLLEDEEEDLKITHHADNTLKSFCKWQKSINMKGDAHPLHHDTAILLTRKDLCAAMNRPC 354
+++EDE+ +++ + TL++FC WQ+ N D HP H+DTAILLTR++ C C
Sbjct: 271 LIVEDEKWGPEVSDNGGLTLRNFCNWQRRFNQPSDRHPEHYDTAILLTRQNFCGQEGL-C 329
Query: 355 ETLGLSHVAGMCQPHRSCSINEDTGLPLAFTVAHELGHSFGIQHDGSGNDCE----PVGK 410
+TLG++ + +C P++SCS+ ED GL A T+AHELGH + HD S C P+GK
Sbjct: 330 DTLGVADIGTICDPNKSCSVIEDEGLQAAHTLAHELGHVLSMPHDDS-KPCTRLFGPMGK 388
Query: 411 RPFIMSPQLLYDAAPLTWSRCSRQYITRFLDRGWGLCLDDPPAKDIIDFPSVPPG--VLY 468
+M+P ++ L WS CS Y+T LD G G CL D PA + P+ PG LY
Sbjct: 389 H-HVMAPLFVHLNQTLPWSPCSAMYLTELLDGGHGDCLLDAPAA-ALPLPTGLPGRMALY 446
Query: 469 DVSHQCRLQYGAYSAFCEDMD--NVCHTLWCSVGTT---CHSKLDAA--VDGTRCGENKW 521
+ QCR +G C + +VC LWC CH+K + DGT CG
Sbjct: 447 QLDQQCRQIFGPDFRHCPNTSAQDVCAQLWCHTDGAEPLCHTKNGSLPWADGTPCGPGHL 506
Query: 522 CLSGECVPVGF--RPEAV-DGGWSGWSAWSICSRSCGMGVQSAERQCTQPTPKYKGRYCV 578
C G C+P RP+ V DGGW+ W W CSR+CG GVQ + R+C P P+ GRYC+
Sbjct: 507 CSEGSCLPEEEVERPKPVADGGWAPWGPWGECSRTCGGGVQFSHRECKDPEPQNGGRYCL 566
Query: 579 GERKRFRLCNLQACPAGRPSFRHVQCSHFDAMLY---KGQLHTWVPVVNDVNP---CELH 632
G R +++ C+ + CP SFR QC ++A Y G L WVP V+P C+L
Sbjct: 567 GRRAKYQSCHTEECPPDGKSFREQQCEKYNAYNYTDMDGNLLQWVPKYAGVSPRDRCKLF 626
Query: 633 CRPANEYFAEKLRDAVVDGTPCYQVRASRDLCINGICKNVGCDFEIDSGAMEDRCGVCHG 692
CR + V+DGT C + +C+ G C GCD +DS D+CGVC G
Sbjct: 627 CRARGRSEFKVFEAKVIDGTLCGPETLA--ICVRGQCVKAGCDHVVDSPRKLDKCGVCGG 684
Query: 693 NGSTCHTVSGTFEEAEGLGYVDVGLIPAGAREIRIQE-----VAEAANFLALRSEDPEKY 747
G++C VSG+ GY D+ IPAGA I +++ V N+LAL++ D + Y
Sbjct: 685 KGNSCRKVSGSLTPT-NYGYNDIVTIPAGATNIDVKQRSHPGVQNDGNYLALKTADGQ-Y 742
Query: 748 FLNGGWTIQ-WNGDYQVAGTTFTYARR-GNWENLTSPGPTKEPVWIQLLFQESN---PGV 802
LNG I D V GT Y+ E L S P EP+ +QLL P V
Sbjct: 743 LLNGNLAISAIEQDILVKGTILKYSGSIATLERLQSFRPLPEPLTVQLLTVPGEVFPPKV 802
Query: 803 HYEYTI----------HREAGGHDEVPPPVFS-WHYGPWTKCTVTCGRGVQRQNVYCLER 851
Y + + +E + + P + + W G W++C+ TCG G QR+ V C R
Sbjct: 803 KYTFFVPNDVDFSMQSSKERATTNIIQPLLHAQWVLGDWSECSSTCGAGWQRRTVEC--R 860
Query: 852 QAGPVDEEHCDPLGRPDDQQRKCSEQPCP 880
C+ +P+D + C Q CP
Sbjct: 861 DPSGQASATCNKALKPED-AKPCESQLCP 888
Score = 52.4 bits (124), Expect = 4e-06
Identities = 23/54 (42%), Positives = 31/54 (57%), Gaps = 3/54 (5%)
Query: 944 ATWAVGNWSQCSVTCGEGTQRRNVLCTNDTG---VPCDEAQQPASEVTCSLPLC 994
A W +G+WS+CS TCG G QRR V C + +G C++A +P C LC
Sbjct: 834 AQWVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPCESQLC 887
Score = 50.8 bits (120), Expect = 1e-05
Identities = 23/59 (38%), Positives = 29/59 (49%), Gaps = 7/59 (11%)
Query: 1519 QPCL--SWYTSSWRECSEACGGGEQQRLVTCPEP-----GLCEEALRPNTTRPCNTHPC 1570
QP L W W ECS CG G Q+R V C +P C +AL+P +PC + C
Sbjct: 829 QPLLHAQWVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPCESQLC 887
Score = 50.1 bits (118), Expect = 2e-05
Identities = 22/57 (38%), Positives = 31/57 (54%), Gaps = 4/57 (7%)
Query: 1572 QWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPCGTEDC 1628
QWV+G W +CS CG G QRR V+C + + S C PE ++PC ++ C
Sbjct: 835 QWVLGDWSECSSTCGAGWQRRTVECRDPS----GQASATCNKALKPEDAKPCESQLC 887
Score = 45.8 bits (107), Expect = 3e-04
Identities = 42/130 (32%), Positives = 54/130 (41%), Gaps = 26/130 (20%)
Query: 1503 CQPGPAKPPAHRPCGAQPCLSWYTSSWRECSEACGGGEQQRLVTC-PEPGLCEEALRPNT 1561
C A+P H G+ P W + CG G +C PE EE RP
Sbjct: 477 CHTDGAEPLCHTKNGSLP--------WAD-GTPCGPGHLCSEGSCLPE----EEVERP-- 521
Query: 1562 TRPCNTHPCTQWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQC-GHEAWPESS 1620
+P W GPWG+CS CGGGVQ +C + + P+ C G A +S
Sbjct: 522 -KPVADGGWAPW--GPWGECSRTCGGGVQFSHRECKDPE---PQNGGRYCLGRRAKYQS- 574
Query: 1621 RPCGTEDCEP 1630
C TE+C P
Sbjct: 575 --CHTEECPP 582
Score = 45.1 bits (105), Expect = 6e-04
Identities = 22/55 (40%), Positives = 29/55 (52%), Gaps = 3/55 (5%)
Query: 1412 NAGWQAGNWSECSTTCGLGAVWRPVRC---SSGRDEDCAPAGRPQPARRCHLRPC 1463
+A W G+WSECS+TCG G R V C S C A +P+ A+ C + C
Sbjct: 833 HAQWVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPCESQLC 887
Score = 40.0 bits (92), Expect = 0.019
Identities = 22/58 (37%), Positives = 28/58 (48%), Gaps = 4/58 (6%)
Query: 1464 ATWHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAHRPCGAQPC 1521
A W G+WS+CS +CG G R V+C RD C KP +PC +Q C
Sbjct: 834 AQWVLGDWSECSSTCGAGWQRRTVEC---RDPSGQASATCNKA-LKPEDAKPCESQLC 887
Score = 35.8 bits (81), Expect = 0.36
Identities = 27/84 (32%), Positives = 34/84 (40%), Gaps = 13/84 (15%)
Query: 1407 PLVVRNAGWQA-GNWSECSTTCGLGAVWRPVRCSSGRDEDCAPAGRPQPARRCHLRPCAT 1465
P V + GW G W ECS TCG G + C +D + GR RR + C T
Sbjct: 521 PKPVADGGWAPWGPWGECSRTCGGGVQFSHREC---KDPEPQNGGRYCLGRRAKYQSCHT 577
Query: 1466 WHSGNWSKCSRSCGGGSSVRDVQC 1489
+C G S R+ QC
Sbjct: 578 ------EECPPD---GKSFREQQC 592
Score = 35.4 bits (80), Expect = 0.47
Identities = 26/75 (34%), Positives = 33/75 (44%), Gaps = 17/75 (22%)
Query: 1420 WSECSTTCGLGAVWRPVRCSSGRDEDCAP---AGRPQPARRCHLRPCATWHSGNWSKCSR 1476
W++ T CG G + CS G C P RP+P P W G W +CSR
Sbjct: 495 WAD-GTPCGPGHL-----CSEG---SCLPEEEVERPKPVADGGWAP---W--GPWGECSR 540
Query: 1477 SCGGGSSVRDVQCVD 1491
+CGGG +C D
Sbjct: 541 TCGGGVQFSHRECKD 555
>gi|195539372 ADAM metallopeptidase with thrombospondin type 1
motif, 5 preproprotein [Homo sapiens]
Length = 930
Score = 396 bits (1018), Expect = e-110
Identities = 277/834 (33%), Positives = 386/834 (46%), Gaps = 99/834 (11%)
Query: 88 GRELRFNLTANQHLLAPGFVSETRRRGGLGRAHIRAHTPACHLLGEVQDPELEGGLAAIS 147
GR +L + + GFV G G + H C G V LA
Sbjct: 95 GRRFLLDLERDGSVGIAGFVP-----AGGGTSAPWRHRSHCFYRGTVDGSPRS--LAVFD 147
Query: 148 ACDGLKGVFQLSNEDYFIEPLDSAPARP---------GHAQPHVVYKRQA------PERL 192
C GL G F + + Y ++PL P G A+ VY R+ P R
Sbjct: 148 LCGGLDGFFAVKHARYTLKPLLRGPWAEEEKGRVYGDGSARILHVYTREGFSFEALPPRA 207
Query: 193 AQRGDSSAP---------------STCGVQVYPELESRRERWEQRQQWRRPRLRRLHQRS 237
+ +S P + Q+ + Q W R R +RS
Sbjct: 208 SCETPASTPEAHEHAPAHSNPSGRAALASQLLDQSALSPAGGSGPQTWWRRR-----RRS 262
Query: 238 VSKEKWVETLVVADAKMVEYHGQPQVESYVLTIMNMVAGLFHDPSIGNPIHITIVRLVLL 297
+S+ + VE L+VADA M +G+ ++ Y+LT+ ++ L+ SI N I + +V++V+L
Sbjct: 263 ISRARQVELLLVADASMARLYGRG-LQHYLLTLASIANRLYSHASIENHIRLAVVKVVVL 321
Query: 298 EDEEEDLKITHHADNTLKSFCKWQKSINMKGDAHPLHHDTAILLTRKDLCAAMNRPCETL 357
D+++ L+++ +A TLK+FCKWQ N GD H H+D AIL TR+DLC + C+TL
Sbjct: 322 GDKDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYDAAILFTREDLCG--HHSCDTL 379
Query: 358 GLSHVAGMCQPHRSCSINEDTGLPLAFTVAHELGHSFGIQHDGSGNDCEPVGKRPF--IM 415
G++ V +C P RSC++ ED GL AFTVAHE+GH G+ HD S E G +M
Sbjct: 380 GMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHDDSKFCEETFGSTEDKRLM 439
Query: 416 SPQLLYDAAPLTWSRCSRQYITRFLDRGWGLCLDDPPAKDIIDFPSVPPGVLYDVSHQCR 475
S L A WS+C+ IT FLD G G CL D P K I+ P PG YD + QC
Sbjct: 440 SSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLPRKQILG-PEELPGQTYDATQQCN 498
Query: 476 LQYGAYSAFCEDMDNVCHTLWCSV----GTTCHSKLDAAVDGTRCGENKWCLSGECVPVG 531
L +G + C MD VC LWC+V C +K AV+GT CG+ + CL G+CV
Sbjct: 499 LTFGPEYSVCPGMD-VCARLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVDKT 557
Query: 532 ---FRPEAVDGGWSGWSAWSICSRSCGMGVQSAERQCTQPTPKYKGRYCVGERKRFRLCN 588
+ + G W W +W CSRSCG GVQ A R C P P+ GRYC G+R +R C+
Sbjct: 558 KKKYYSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCS 617
Query: 589 LQACPAGRPSFRHVQCS-----HFDAMLYKGQLHTWVPVVNDVNP---CELHCRPANEYF 640
L CP SFRH QC DA K + WVP V P C+L CR +
Sbjct: 618 LMPCPPNGKSFRHEQCEAKNGYQSDAKGVKTFVE-WVPKYAGVLPADVCKLTCRAKGTGY 676
Query: 641 AEKLRDAVVDGTPCYQVRASRDLCINGICKNVGCDFEIDSGAMEDRCGVCHGNGSTCHTV 700
V DGT C S +C+ G C GCD I S D+CGVC G+ S+C +
Sbjct: 677 YVVFSPKVTDGTECRLY--SNSVCVRGKCVRTGCDGIIGSKLQYDKCGVCGGDNSSCTKI 734
Query: 701 SGTFEEAEGLGYVDVGLIPAGAREIRIQEV-----AEAANFLALRSEDPEKYFLNGGWTI 755
GTF + + GY DV IP GA I++++ +LAL+ ++ E Y +NG + I
Sbjct: 735 VGTFNK-KSKGYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKKNGE-YLINGKYMI 792
Query: 756 QWNGD-YQVAGTTFTY---ARRGNWENLTSPGPTKEPVWIQLLFQESNPGVHYEYTI--- 808
+ + GT Y + R ++ + TKE + +Q+L + + Y+
Sbjct: 793 STSETIIDINGTVMNYSGWSHRDDFLHGMGYSATKEILIVQILATDPTKPLDVRYSFFVP 852
Query: 809 --------------HREAGGHDEVPPPVFSWHYGPWTKCTVTCGRGVQRQNVYC 848
+ G H P W GPW C+ TC G + V C
Sbjct: 853 KKSTPKVNSVTSHGSNKVGSHTSQP----QWVTGPWLACSRTCDTGWHTRTVQC 902
Score = 38.1 bits (87), Expect = 0.073
Identities = 18/52 (34%), Positives = 24/52 (46%), Gaps = 3/52 (5%)
Query: 1415 WQAGNWSECSTTCGLGAVWRPVRCSSGR---DEDCAPAGRPQPARRCHLRPC 1463
W G W CS TC G R V+C G + C + RP ++C L+ C
Sbjct: 879 WVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCPLSQRPSAFKQCLLKKC 930
Score = 36.2 bits (82), Expect = 0.28
Identities = 19/57 (33%), Positives = 25/57 (43%), Gaps = 9/57 (15%)
Query: 1572 QWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPCGTEDC 1628
QWV GPW CS C G R V+C +D ++ + P S RP + C
Sbjct: 878 QWVTGPWLACSRTCDTGWHTRTVQC---------QDGNRKLAKGCPLSQRPSAFKQC 925
Score = 34.3 bits (77), Expect = 1.1
Identities = 22/56 (39%), Positives = 23/56 (41%), Gaps = 7/56 (12%)
Query: 1576 GPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQC-GHEAWPESSRPCGTEDCEP 1630
G WGQCS CGGGVQ C N P + C G A R C C P
Sbjct: 574 GSWGQCSRSCGGGVQFAYRHCNNP---APRNNGRYCTGKRA---IYRSCSLMPCPP 623
Score = 34.3 bits (77), Expect = 1.1
Identities = 17/52 (32%), Positives = 22/52 (42%), Gaps = 3/52 (5%)
Query: 946 WAVGNWSQCSVTCGEGTQRRNVLCTNDT---GVPCDEAQQPASEVTCSLPLC 994
W G W CS TC G R V C + C +Q+P++ C L C
Sbjct: 879 WVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCPLSQRPSAFKQCLLKKC 930
Score = 33.9 bits (76), Expect = 1.4
Identities = 19/52 (36%), Positives = 23/52 (44%), Gaps = 1/52 (1%)
Query: 1466 WHSGNWSKCSRSCGGGSSVRDVQCVD-TRDLRPLRPFHCQPGPAKPPAHRPC 1516
W +G W CSR+C G R VQC D R L P +P K + C
Sbjct: 879 WVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCPLSQRPSAFKQCLLKKC 930
Score = 33.1 bits (74), Expect = 2.3
Identities = 20/57 (35%), Positives = 25/57 (43%), Gaps = 6/57 (10%)
Query: 1466 WHS-GNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAHRPCGAQPC 1521
W S G+W +CSRSCGGG C + R +C K +R C PC
Sbjct: 570 WGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNNGR--YC---TGKRAIYRSCSLMPC 621
>gi|157427675 ADAM metallopeptidase with thrombospondin type 1
motif, 4 preproprotein [Homo sapiens]
Length = 837
Score = 376 bits (965), Expect = e-103
Identities = 283/812 (34%), Positives = 387/812 (47%), Gaps = 97/812 (11%)
Query: 17 LLLLLCALAPGAPGPAPGRATEGRAALDIVHPVRVDAGGSFLSYELWPRALRKRDVSVRR 76
LLLLL +L P A +P E +IV P +++ GS L P L R
Sbjct: 38 LLLLLASLLPSARLASPLPREE-----EIVFPEKLN--GSVLPGSGAPARLLCR------ 84
Query: 77 DAPAFYELQYRGRELRFNLTANQHLLAPGFVSETRRRGGLGRAH--IRAHTPACHLLGEV 134
LQ G L L + + G + LG+A + P +L G +
Sbjct: 85 -------LQAFGETLLLELEQDSGVQVEGLTVQY-----LGQAPELLGGAEPGTYLTGTI 132
Query: 135 Q-DPELEGGLAAISACDG--LKGVFQLSNEDYFIEPLDSA-PARPGHAQPHVVYKRQAPE 190
DPE L DG L GV Q + ++PL+ P G H++ +R++P
Sbjct: 133 NGDPESVASLH----WDGGALLGVLQYRGAELHLQPLEGGTPNSAGGPGAHIL-RRKSPA 187
Query: 191 RLAQRGDSSAPSTCGVQVYPELESRRERWEQRQQWRRPRLRRLHQRSVSKEKWVETLVVA 250
S C V+ S PR RR +R S ++VETLVVA
Sbjct: 188 -------SGQGPMCNVKAPLGSPS-------------PRPRRA-KRFASLSRFVETLVVA 226
Query: 251 DAKMVEYHGQPQVESYVLTIMNMVAGLFHDPSIGNPIHITIVRLVLLEDEEEDLKITHHA 310
D KM +HG ++ Y+LT+M A F PSI NP+ + + RLV+L EE ++ A
Sbjct: 227 DDKMAAFHGAG-LKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSA 285
Query: 311 DNTLKSFCKWQKSINMKGDAHPLHHDTAILLTRKDLCAAMNRPCETLGLSHVAGMCQPHR 370
TL+SFC WQ+ +N D+ P H DTAIL TR+DLC C+TLG++ V +C P R
Sbjct: 286 AQTLRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLCGVST--CDTLGMADVGTVCDPAR 343
Query: 371 SCSINEDTGLPLAFTVAHELGHSFGIQHDGSGNDC----EPVGKRPFIMSPQLLYDAAPL 426
SC+I ED GL AFT AHELGH F + HD S C P+ +M+P + +
Sbjct: 344 SCAIVEDDGLQSAFTAAHELGHVFNMLHDNS-KPCISLNGPLSTSRHVMAPVMAHVDPEE 402
Query: 427 TWSRCSRQYITRFLDRGWGLCLDDPPAKDIIDFPSVPPGVLYDVSHQCRLQYGAYSAFCE 486
WS CS ++IT FLD G+G CL D P + P PG YD QC+L +G S C
Sbjct: 403 PWSPCSARFITDFLDNGYGHCLLDKPEAP-LHLPVTFPGKDYDADRQCQLTFGPDSRHCP 461
Query: 487 DMDNVCHTLWCS----VGTTCHSKLDAAVDGTRCGENKWCLSGECVPVGFR-----PEAV 537
+ C LWCS C +K DGT CG + C+ G C+ + P+A
Sbjct: 462 QLPPPCAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRCLHMDQLQDFNIPQA- 520
Query: 538 DGGWSGWSAWSICSRSCGMGVQSAERQCTQPTPKYKGRYCVGERKRFRLCNLQACPAGRP 597
GGW W W CSR+CG GVQ + R CT+P P+ G+YC G R RFR CN + CP G
Sbjct: 521 -GGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPTGSA 579
Query: 598 -SFRHVQCSHFDAML-----YKGQLHTWVPVVNDVNP---CELHCRPANEYFAEKLRDAV 648
+FR QC+ ++ + G + WVP V P C+L C+ + L V
Sbjct: 580 LTFREEQCAAYNHRTDLFKSFPGPM-DWVPRYTGVAPQDQCKLTCQAQALGYYYVLEPRV 638
Query: 649 VDGTPCYQVRASRDLCINGICKNVGCDFEIDSGAMEDRCGVCHGNGSTCHTVSGTFEEAE 708
VDGTPC S +C+ G C + GCD I S D+C VC G+GS C SG+F +
Sbjct: 639 VDGTPCSP--DSSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSGCSKQSGSFRKFR 696
Query: 709 GLGYVDVGLIPAGAREIRIQEVAEAAN---FLALRSEDPEKYFLNGGWTIQWNGDYQVAG 765
GY +V IPAGA I +++ + +LAL+ D Y LNG +T+ + V
Sbjct: 697 -YGYNNVVTIPAGATHILVRQQGNPGHRSIYLALKLPD-GSYALNGEYTLMPSPTDVVLP 754
Query: 766 TTFTYARRGNW---ENLTSPGPTKEPVWIQLL 794
+ G E L+ GP +P+ +Q+L
Sbjct: 755 GAVSLRYSGATAASETLSGHGPLAQPLTLQVL 786
Score = 41.2 bits (95), Expect = 0.009
Identities = 22/53 (41%), Positives = 23/53 (43%), Gaps = 5/53 (9%)
Query: 1576 GPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPCGTEDC 1628
GPWG CS CGGGVQ C +P C E R C TEDC
Sbjct: 527 GPWGDCSRTCGGGVQFSSRDCTRP---VPRNGGKYC--EGRRTRFRSCNTEDC 574
Score = 32.3 bits (72), Expect = 4.0
Identities = 20/57 (35%), Positives = 30/57 (52%), Gaps = 10/57 (17%)
Query: 827 YGPWTKCTVTCGRGVQRQNVYC---LERQAGPVDEEHCDPLGRPDDQQRKCSEQPCP 880
+GPW C+ TCG GVQ + C + R G ++C+ GR + R C+ + CP
Sbjct: 526 WGPWGDCSRTCGGGVQFSSRDCTRPVPRNGG----KYCE--GR-RTRFRSCNTEDCP 575
Score = 31.6 bits (70), Expect = 6.8
Identities = 18/48 (37%), Positives = 19/48 (39%), Gaps = 8/48 (16%)
Query: 1529 WRECSEACGGGEQQRLVTCPEP------GLCEEALRPNTTRPCNTHPC 1570
W +CS CGGG Q C P CE R R CNT C
Sbjct: 529 WGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEG--RRTRFRSCNTEDC 574
>gi|239756385 PREDICTED: similar to hCG1991431 [Homo sapiens]
Length = 232
Score = 370 bits (950), Expect = e-102
Identities = 178/207 (85%), Positives = 183/207 (88%), Gaps = 1/207 (0%)
Query: 1209 PWRDRTNEV-FKDDEEPKGRGAPHLPPRPSSTLPPLSPVGSTHSSPSPDVAELWTGGTVA 1267
P RT + F +DEEP+G GAPHLPPRPS TLP L PV STHSSPSPDVAELWTGGTVA
Sbjct: 26 PLHGRTGPMRFSNDEEPEGCGAPHLPPRPSPTLPTLYPVSSTHSSPSPDVAELWTGGTVA 85
Query: 1268 WEPALEGGLGPVDSELWPTVGVASLLPPPIAPLPEMKVRDSSLEPGTPSFPTPGPGSWDL 1327
WE ALEGGLGPVDSELWPTVGVASL PPPIAPLPEMK DS L+PGTP+FPTPGPG WDL
Sbjct: 86 WESALEGGLGPVDSELWPTVGVASLPPPPIAPLPEMKGNDSPLQPGTPTFPTPGPGLWDL 145
Query: 1328 QTVAVWGTFLPTTLTGLGHMPEPALNPGPKGQPESLSPEVPLSSRLLSTPAWDSPANSHR 1387
QTVAVWGTFLPTTLT LGH PEPALNPGPKGQPESLSPEVPLSSRLLS PAWDSPANSHR
Sbjct: 146 QTVAVWGTFLPTTLTDLGHTPEPALNPGPKGQPESLSPEVPLSSRLLSMPAWDSPANSHR 205
Query: 1388 VPETQPLAPSLAEAGPPADPLVVRNAG 1414
PETQPL PSLAEAGPP DPLVVRNAG
Sbjct: 206 APETQPLPPSLAEAGPPTDPLVVRNAG 232
Score = 34.3 bits (77), Expect = 1.1
Identities = 54/198 (27%), Positives = 69/198 (34%), Gaps = 32/198 (16%)
Query: 1076 LSYGPSEEPDLDLAGTGDRTPPPHSHPAAPSTGSPVPATEPPAAKE-------------- 1121
+ + EEP+ G G PP P P T PV +T + +
Sbjct: 34 MRFSNDEEPE----GCGAPHLPPRPSPTLP-TLYPVSSTHSSPSPDVAELWTGGTVAWES 88
Query: 1122 --EGVLGPWSPSPWPSQAGRS-PPPPSEQTP---GN--PLINFLPEEDTP-IGAPDLGLP 1172
EG LGP WP+ S PPPP P GN PL P TP G DL
Sbjct: 89 ALEGGLGPVDSELWPTVGVASLPPPPIAPLPEMKGNDSPLQPGTPTFPTPGPGLWDLQTV 148
Query: 1173 SLSWPRVSTDGLQTPATPE-SQNDFPVGKDSQSQLPPPWRDRTNEVFKDDEEPKGRGAPH 1231
++ + T TPE + N P G+ P R + D AP
Sbjct: 149 AVWGTFLPTTLTDLGHTPEPALNPGPKGQPESLSPEVPLSSRLLSMPAWDSPANSHRAPE 208
Query: 1232 ---LPPRPSSTLPPLSPV 1246
LPP + PP P+
Sbjct: 209 TQPLPPSLAEAGPPTDPL 226
>gi|73695936 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 2 preproprotein [Homo sapiens]
Length = 1371
Score = 355 bits (912), Expect = 2e-97
Identities = 266/825 (32%), Positives = 365/825 (44%), Gaps = 68/825 (8%)
Query: 229 RLRRLHQRSVSKEKWVETLVVADAKMVEYHGQPQVESYVLTIMNMVAGLFHDPSIGNPIH 288
R R+ +R+ +E LV + + H Q E YVLT +N+ A L DPS+G
Sbjct: 67 RQRQRQRRAAGGILHLELLVAVGPDVFQAH-QEDTERYVLTNLNIGAELLRDPSLGAQFR 125
Query: 289 ITIVRLVLLEDEEEDLKITHHADNTLKSFCKWQKSINMKGDAHPLHHDTAILLTRKDL-C 347
+ +V++V+L + E IT + ++L S C W ++IN + D P H D + +TR DL
Sbjct: 126 VHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITRFDLEL 185
Query: 348 AAMNRPCETLGLSHVAGMCQPHRSCSINEDTGLPLAFTVAHELGHSFGIQHDGS-GNDCE 406
NR + G++ + G C P SC I EDTG L T+AHE+GHSFG++HDG+ G+ C
Sbjct: 186 PDGNR--QVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGSGCG 243
Query: 407 PVGKRPFIMSPQLLYDAAPLTWSRCSRQYITRFLDRGWGLCLDDPPAKDIIDF---PSVP 463
P G +M+ A L WS CSR+ + L G C+ DPP P
Sbjct: 244 PSGH---VMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGHPPDAQ 300
Query: 464 PGVLYDVSHQCRLQYGAYSAFC----EDMDNVCHTLWCSVG----TTCHSKLDAAVDGTR 515
PG+ Y + QCR+ +G + C E +D +C L C ++C L +DGT
Sbjct: 301 PGLYYSANEQCRVAFGPKAVACTFAREHLD-MCQALSCHTDPLDQSSCSRLLVPLLDGTE 359
Query: 516 CGENKWCLSGECVP-VGFRP-EAVDGGWSGWSAWSICSRSCGMGVQSAERQCTQPTPKYK 573
CG KWC G C V P AV G WS W S CSRSCG GV + RQC P P +
Sbjct: 360 CGVEKWCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFG 419
Query: 574 GRYCVGERKRFRLCNLQACPAGRPSFRHVQCSHFDAMLYK-----GQLHTW---VPVVND 625
GR CVG + +CN QAC + F QC+ D + + W VP
Sbjct: 420 GRACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQG 479
Query: 626 VNPCELHCRPANEYFAEKLRDAVVDGTPCYQVRASRD----LCINGICKNVGCDFEIDSG 681
C CR E F K D+ +DGT C D LC++G C+ GCD +DS
Sbjct: 480 DALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQ 539
Query: 682 AMEDRCGVCHGNGSTCHTVSGTFEEAEGLGYVDVGLIPAGAREIRIQEVAEAANFLALRS 741
+ DRC VC G+ STC G+F YV + + I LA+R
Sbjct: 540 QVWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVRI 599
Query: 742 EDPEKYFLNGGWTIQWNG-----------DYQVAGTTFTYARRGNWENLTSPGPTKEPVW 790
+Y + G +I N +Y+VA T R E + GP +E
Sbjct: 600 GG--RYVVAGKMSISPNTTYPSLLEDGRVEYRVA---LTEDRLPRLEEIRIWGPLQEDAD 654
Query: 791 IQLLFQESNPGVHYEYTIHREAGGHDEVPPPVFSWHY----GPWTKCTVTCGRGVQRQNV 846
IQ+ G Y + P P +W + GP C+V+CG G++ N
Sbjct: 655 IQVY---RRYGEEYGNLTRPDITFTYFQPKPRQAWVWAAVRGP---CSVSCGAGLRWVNY 708
Query: 847 YCLER-QAGPVDEEHCDPLGRPDDQQRKCSEQPCPARWWAGEWQLCSSSCGPGGLSRRAV 905
CL++ + V+ C +P C +PCP W G++ CS+SCG GGL R V
Sbjct: 709 SCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCG-GGLRERPV 767
Query: 906 LCIRSVGLDEQSALEPPACEHLPRPPTET--PCNRHVPCPATWAVGNWSQCSVTCGEGTQ 963
C+ + G L P C + P CN PCPA W V S C+ G G
Sbjct: 768 RCVEAQG-SLLKTLPPARCRAGAQQPAVALETCNPQ-PCPARWEVSEPSSCTSAGGAGLA 825
Query: 964 RRNVLCT-NDTGVPCDEAQQPASEVTCSLPLCRWPLGTLGPEGSG 1007
N C G+ + P S V LP +G P G G
Sbjct: 826 LENETCVPGADGLEAPVTEGPGS-VDEKLPAPEPCVGMSCPPGWG 869
Score = 110 bits (274), Expect = 2e-23
Identities = 82/232 (35%), Positives = 112/232 (48%), Gaps = 26/232 (11%)
Query: 830 WT----KCTVTCGRGVQRQNVYCLERQAG-PVDEEHCDPLGRPDDQQRKCSEQPCPARWW 884
WT C+V+CGRG+ C++ PV EE C +P ++ C PCPARW
Sbjct: 897 WTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARW- 955
Query: 885 AGEWQL--CSSSCGPGGLSRRAVLCIRSVGLDE-QSALEPPACEHLPRPPTETPCNRHVP 941
+++L CS SCG G+ RR + C R+ G D+ + L C+ LPRP + C+ P
Sbjct: 956 --QYKLAACSVSCG-RGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLE-P 1011
Query: 942 CPATWAVGNWSQCSVTCGEGTQRRNVLCTN-DTG--VPCDEAQ-----QPASEVTCSLPL 993
CP W V + CS +CG GT RR+V C D G V DEA +P + V C +
Sbjct: 1012 CPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIAD 1071
Query: 994 C--RWPLGTLGPEGSGSGSSSHELFNEADFIPHHLAPRPSPASS--PKPGTM 1041
C RW +GT E S S + + P AP P+ PKP T+
Sbjct: 1072 CTYRWHVGT-WMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTV 1122
Score = 106 bits (265), Expect = 2e-22
Identities = 77/211 (36%), Positives = 95/211 (45%), Gaps = 26/211 (12%)
Query: 788 PVWIQLLFQESNPGVHYEYTIHREAGGHDEVPPPVFSWHYGPWTKCTVTCGRGVQRQNVY 847
PV +L S PG E VP P W Y C+V+CGRGV R+ +Y
Sbjct: 927 PVQEELCGLASKPGSRREVC--------QAVPCPA-RWQY-KLAACSVSCGRGVVRRILY 976
Query: 848 CLERQAGPVDEE-----HCDPLGRPDDQQRKCSEQPCPARWWAGEWQLCSSSCGPGGLSR 902
C EE C L RP+ Q+ CS +PCP RW CS+SCG G +R
Sbjct: 977 CARAHGEDDGEEILLDTQCQGLPRPEPQEA-CSLEPCPPRWKVMSLGPCSASCGLG-TAR 1034
Query: 903 RAVLCIRSVGLDEQSALE--PPACEHLPRPPTETPCNRHVPCPATWAVGNWSQCSVTCGE 960
R+V C++ LD+ +E AC L RP PC C W VG W +CSV+CG+
Sbjct: 1035 RSVACVQ---LDQGQDVEVDEAACAALVRPEASVPC-LIADCTYRWHVGTWMECSVSCGD 1090
Query: 961 GTQRRNVLCTN---DTGVPCDEAQQPASEVT 988
G QRR C VP D Q VT
Sbjct: 1091 GIQRRRDTCLGPQAQAPVPADFCQHLPKPVT 1121
Score = 94.4 bits (233), Expect = 9e-19
Identities = 77/261 (29%), Positives = 101/261 (38%), Gaps = 35/261 (13%)
Query: 1410 VRNAGWQAGNWS----ECSTTCGLGAVWRPVRCSSG------RDEDCAPAGRPQPARR-C 1458
+R A W+ CS +CG G + C ++E C A +P R C
Sbjct: 887 IRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVC 946
Query: 1459 HLRPCATWHSGNWSKCSRSCGGGSSVRDVQCV------DTRDLRPLRPFHCQPGPAKPPA 1512
PC + CS SCG G R + C D ++ L CQ G +P
Sbjct: 947 QAVPCPARWQYKLAACSVSCGRGVVRRILYCARAHGEDDGEEI--LLDTQCQ-GLPRPEP 1003
Query: 1513 HRPCGAQPCLS-WYTSSWRECSEACGGGEQQRLVTCPE----------PGLCEEALRPNT 1561
C +PC W S CS +CG G +R V C + C +RP
Sbjct: 1004 QEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEA 1063
Query: 1562 TRPCNTHPCT-QWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESS 1620
+ PC CT +W VG W +CS CG G+QRR C+ Q P +D C H P +
Sbjct: 1064 SVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAP-VPADFCQHLPKPVTV 1122
Query: 1621 RPCGTEDCEPVEPPRCERDRL 1641
R C C V C R L
Sbjct: 1123 RGCWAGPC--VGQGACGRQHL 1141
Score = 75.5 bits (184), Expect = 4e-13
Identities = 72/265 (27%), Positives = 96/265 (36%), Gaps = 60/265 (22%)
Query: 1423 CSTTCGLGAVWRPVRCSSGRDEDCAPA----GRPQPA---RRCHLRPCAT-WHSGNWSKC 1474
CS +CG G W C ++ G QP C L PC W G++ C
Sbjct: 695 CSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPC 754
Query: 1475 SRSCGGGSSVRDVQCVDTRD--LRPLRPFHCQPGPAKPP-AHRPCGAQPC-LSWYTSSWR 1530
S SCGGG R V+CV+ + L+ L P C+ G +P A C QPC W S
Sbjct: 755 SASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPS 814
Query: 1531 ECSEACGGGEQQRLVTC------------PEPGLCEEALRPNTTRPCNTHPCT------- 1571
C+ A G G TC PG +E L PC C
Sbjct: 815 SCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKL--PAPEPCVGMSCPPGWGHLD 872
Query: 1572 -----QWVVGPW-----------------GQCSGPCGGGVQRRLVKCVNTQTGLPEEDSD 1609
+ PW G CS CG G+ C+++ +P ++ +
Sbjct: 873 ATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQE-E 931
Query: 1610 QCGHEAWPESSRPCGTEDCEPVEPP 1634
CG + P S R E C+ V P
Sbjct: 932 LCGLASKPGSRR----EVCQAVPCP 952
Score = 74.7 bits (182), Expect = 7e-13
Identities = 77/274 (28%), Positives = 98/274 (35%), Gaps = 63/274 (22%)
Query: 1415 WQAGNWSECSTTCGLGAVWRPVRC--SSGRDEDCAP-----AGRPQPA---RRCHLRPC- 1463
W G++ CS +CG G RPVRC + G P AG QPA C+ +PC
Sbjct: 746 WAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCP 805
Query: 1464 ATWHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPA--KPPAHRPC----- 1516
A W S C+ + G G ++ + CV D P PG K PA PC
Sbjct: 806 ARWEVSEPSSCTSAGGAGLALENETCVPGADGLE-APVTEGPGSVDEKLPAPEPCVGMSC 864
Query: 1517 -------------------------GAQPCLSWYTSSWRECSEACGGGEQQRLVTCPEPG 1551
GAQ W T + CS +CG G + C +
Sbjct: 865 PPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVW-TPAAGSCSVSCGRGLMELRFLCMDSA 923
Query: 1552 --------LCEEALRPNTTRP-CNTHPCTQWVVGPWGQCSGPCGGGVQRRLVKCVNTQTG 1602
LC A +P + R C PC CS CG GV RR++ C
Sbjct: 924 LRVPVQEELCGLASKPGSRREVCQAVPCPARWQYKLAACSVSCGRGVVRRILYCARAH-- 981
Query: 1603 LPEEDSD------QCGHEAWPESSRPCGTEDCEP 1630
E+D + QC PE C E C P
Sbjct: 982 -GEDDGEEILLDTQCQGLPRPEPQEACSLEPCPP 1014
Score = 70.1 bits (170), Expect = 2e-11
Identities = 49/143 (34%), Positives = 64/143 (44%), Gaps = 12/143 (8%)
Query: 810 REAGGHDEVPPPVFSWHYGPWTKCTVTCGRGVQRQNVYCLERQAGP---VDEEHCDPLGR 866
+EA + PP GP C+ +CG G R++V C++ G VDE C L R
Sbjct: 1004 QEACSLEPCPPRWKVMSLGP---CSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVR 1060
Query: 867 PDDQQRKCSEQPCPARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEH 926
P+ C C RW G W CS SCG G + RR C+ G Q+ + C+H
Sbjct: 1061 PEASV-PCLIADCTYRWHVGTWMECSVSCGDG-IQRRRDTCL---GPQAQAPVPADFCQH 1115
Query: 927 LPRPPTETPCNRHVPCPATWAVG 949
LP+P T C PC A G
Sbjct: 1116 LPKPVTVRGCWAG-PCVGQGACG 1137
Score = 50.4 bits (119), Expect = 1e-05
Identities = 26/69 (37%), Positives = 35/69 (50%), Gaps = 2/69 (2%)
Query: 823 FSWHYGPWTKCTVTCGRGVQRQNVYCLERQA-GPVDEEHCDPLGRPDDQQRKCSEQPCPA 881
+ WH G W +C+V+CG G+QR+ CL QA PV + C L +P R C PC
Sbjct: 1074 YRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKP-VTVRGCWAGPCVG 1132
Query: 882 RWWAGEWQL 890
+ G L
Sbjct: 1133 QGACGRQHL 1141
Score = 48.9 bits (115), Expect = 4e-05
Identities = 31/96 (32%), Positives = 45/96 (46%), Gaps = 11/96 (11%)
Query: 1519 QPCLSWYTSSWR-ECSEACGGGEQQRLVTC--------PEPGLCEEALRPNT-TRPCNTH 1568
+P +W ++ R CS +CG G + +C E C+ + +P C
Sbjct: 681 KPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLE 740
Query: 1569 PCTQ-WVVGPWGQCSGPCGGGVQRRLVKCVNTQTGL 1603
PC W VG +G CS CGGG++ R V+CV Q L
Sbjct: 741 PCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSL 776
Score = 33.1 bits (74), Expect = 2.3
Identities = 28/70 (40%), Positives = 30/70 (42%), Gaps = 13/70 (18%)
Query: 1425 TTCGLGAVWRPVRCSSGRDEDCAPAGRPQPARRCHLRPCATWHS-GNWSKCSRSCGGGSS 1483
T CG+ W CS GR C P H R W S G S CSRSCGGG
Sbjct: 358 TECGVEK-W----CSKGR---CRSLVELTPIAAVHGR----WSSWGPRSPCSRSCGGGVV 405
Query: 1484 VRDVQCVDTR 1493
R QC + R
Sbjct: 406 TRRRQCNNPR 415
>gi|21265034 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 1 preproprotein [Homo sapiens]
Length = 1427
Score = 355 bits (912), Expect = 2e-97
Identities = 266/825 (32%), Positives = 365/825 (44%), Gaps = 68/825 (8%)
Query: 229 RLRRLHQRSVSKEKWVETLVVADAKMVEYHGQPQVESYVLTIMNMVAGLFHDPSIGNPIH 288
R R+ +R+ +E LV + + H Q E YVLT +N+ A L DPS+G
Sbjct: 67 RQRQRQRRAAGGILHLELLVAVGPDVFQAH-QEDTERYVLTNLNIGAELLRDPSLGAQFR 125
Query: 289 ITIVRLVLLEDEEEDLKITHHADNTLKSFCKWQKSINMKGDAHPLHHDTAILLTRKDL-C 347
+ +V++V+L + E IT + ++L S C W ++IN + D P H D + +TR DL
Sbjct: 126 VHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITRFDLEL 185
Query: 348 AAMNRPCETLGLSHVAGMCQPHRSCSINEDTGLPLAFTVAHELGHSFGIQHDGS-GNDCE 406
NR + G++ + G C P SC I EDTG L T+AHE+GHSFG++HDG+ G+ C
Sbjct: 186 PDGNR--QVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGSGCG 243
Query: 407 PVGKRPFIMSPQLLYDAAPLTWSRCSRQYITRFLDRGWGLCLDDPPAKDIIDF---PSVP 463
P G +M+ A L WS CSR+ + L G C+ DPP P
Sbjct: 244 PSGH---VMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGHPPDAQ 300
Query: 464 PGVLYDVSHQCRLQYGAYSAFC----EDMDNVCHTLWCSVG----TTCHSKLDAAVDGTR 515
PG+ Y + QCR+ +G + C E +D +C L C ++C L +DGT
Sbjct: 301 PGLYYSANEQCRVAFGPKAVACTFAREHLD-MCQALSCHTDPLDQSSCSRLLVPLLDGTE 359
Query: 516 CGENKWCLSGECVP-VGFRP-EAVDGGWSGWSAWSICSRSCGMGVQSAERQCTQPTPKYK 573
CG KWC G C V P AV G WS W S CSRSCG GV + RQC P P +
Sbjct: 360 CGVEKWCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFG 419
Query: 574 GRYCVGERKRFRLCNLQACPAGRPSFRHVQCSHFDAMLYK-----GQLHTW---VPVVND 625
GR CVG + +CN QAC + F QC+ D + + W VP
Sbjct: 420 GRACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQG 479
Query: 626 VNPCELHCRPANEYFAEKLRDAVVDGTPCYQVRASRD----LCINGICKNVGCDFEIDSG 681
C CR E F K D+ +DGT C D LC++G C+ GCD +DS
Sbjct: 480 DALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQ 539
Query: 682 AMEDRCGVCHGNGSTCHTVSGTFEEAEGLGYVDVGLIPAGAREIRIQEVAEAANFLALRS 741
+ DRC VC G+ STC G+F YV + + I LA+R
Sbjct: 540 QVWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVRI 599
Query: 742 EDPEKYFLNGGWTIQWNG-----------DYQVAGTTFTYARRGNWENLTSPGPTKEPVW 790
+Y + G +I N +Y+VA T R E + GP +E
Sbjct: 600 GG--RYVVAGKMSISPNTTYPSLLEDGRVEYRVA---LTEDRLPRLEEIRIWGPLQEDAD 654
Query: 791 IQLLFQESNPGVHYEYTIHREAGGHDEVPPPVFSWHY----GPWTKCTVTCGRGVQRQNV 846
IQ+ G Y + P P +W + GP C+V+CG G++ N
Sbjct: 655 IQVY---RRYGEEYGNLTRPDITFTYFQPKPRQAWVWAAVRGP---CSVSCGAGLRWVNY 708
Query: 847 YCLER-QAGPVDEEHCDPLGRPDDQQRKCSEQPCPARWWAGEWQLCSSSCGPGGLSRRAV 905
CL++ + V+ C +P C +PCP W G++ CS+SCG GGL R V
Sbjct: 709 SCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCG-GGLRERPV 767
Query: 906 LCIRSVGLDEQSALEPPACEHLPRPPTET--PCNRHVPCPATWAVGNWSQCSVTCGEGTQ 963
C+ + G L P C + P CN PCPA W V S C+ G G
Sbjct: 768 RCVEAQG-SLLKTLPPARCRAGAQQPAVALETCNPQ-PCPARWEVSEPSSCTSAGGAGLA 825
Query: 964 RRNVLCT-NDTGVPCDEAQQPASEVTCSLPLCRWPLGTLGPEGSG 1007
N C G+ + P S V LP +G P G G
Sbjct: 826 LENETCVPGADGLEAPVTEGPGS-VDEKLPAPEPCVGMSCPPGWG 869
Score = 110 bits (274), Expect = 2e-23
Identities = 82/232 (35%), Positives = 112/232 (48%), Gaps = 26/232 (11%)
Query: 830 WT----KCTVTCGRGVQRQNVYCLERQAG-PVDEEHCDPLGRPDDQQRKCSEQPCPARWW 884
WT C+V+CGRG+ C++ PV EE C +P ++ C PCPARW
Sbjct: 897 WTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARW- 955
Query: 885 AGEWQL--CSSSCGPGGLSRRAVLCIRSVGLDE-QSALEPPACEHLPRPPTETPCNRHVP 941
+++L CS SCG G+ RR + C R+ G D+ + L C+ LPRP + C+ P
Sbjct: 956 --QYKLAACSVSCG-RGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLE-P 1011
Query: 942 CPATWAVGNWSQCSVTCGEGTQRRNVLCTN-DTG--VPCDEAQ-----QPASEVTCSLPL 993
CP W V + CS +CG GT RR+V C D G V DEA +P + V C +
Sbjct: 1012 CPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIAD 1071
Query: 994 C--RWPLGTLGPEGSGSGSSSHELFNEADFIPHHLAPRPSPASS--PKPGTM 1041
C RW +GT E S S + + P AP P+ PKP T+
Sbjct: 1072 CTYRWHVGT-WMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTV 1122
Score = 106 bits (265), Expect = 2e-22
Identities = 77/211 (36%), Positives = 95/211 (45%), Gaps = 26/211 (12%)
Query: 788 PVWIQLLFQESNPGVHYEYTIHREAGGHDEVPPPVFSWHYGPWTKCTVTCGRGVQRQNVY 847
PV +L S PG E VP P W Y C+V+CGRGV R+ +Y
Sbjct: 927 PVQEELCGLASKPGSRREVC--------QAVPCPA-RWQY-KLAACSVSCGRGVVRRILY 976
Query: 848 CLERQAGPVDEE-----HCDPLGRPDDQQRKCSEQPCPARWWAGEWQLCSSSCGPGGLSR 902
C EE C L RP+ Q+ CS +PCP RW CS+SCG G +R
Sbjct: 977 CARAHGEDDGEEILLDTQCQGLPRPEPQEA-CSLEPCPPRWKVMSLGPCSASCGLG-TAR 1034
Query: 903 RAVLCIRSVGLDEQSALE--PPACEHLPRPPTETPCNRHVPCPATWAVGNWSQCSVTCGE 960
R+V C++ LD+ +E AC L RP PC C W VG W +CSV+CG+
Sbjct: 1035 RSVACVQ---LDQGQDVEVDEAACAALVRPEASVPC-LIADCTYRWHVGTWMECSVSCGD 1090
Query: 961 GTQRRNVLCTN---DTGVPCDEAQQPASEVT 988
G QRR C VP D Q VT
Sbjct: 1091 GIQRRRDTCLGPQAQAPVPADFCQHLPKPVT 1121
Score = 94.0 bits (232), Expect = 1e-18
Identities = 73/248 (29%), Positives = 97/248 (39%), Gaps = 33/248 (13%)
Query: 1410 VRNAGWQAGNWS----ECSTTCGLGAVWRPVRCSSG------RDEDCAPAGRPQPARR-C 1458
+R A W+ CS +CG G + C ++E C A +P R C
Sbjct: 887 IRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVC 946
Query: 1459 HLRPCATWHSGNWSKCSRSCGGGSSVRDVQCV------DTRDLRPLRPFHCQPGPAKPPA 1512
PC + CS SCG G R + C D ++ L CQ G +P
Sbjct: 947 QAVPCPARWQYKLAACSVSCGRGVVRRILYCARAHGEDDGEEI--LLDTQCQ-GLPRPEP 1003
Query: 1513 HRPCGAQPCLS-WYTSSWRECSEACGGGEQQRLVTCPE----------PGLCEEALRPNT 1561
C +PC W S CS +CG G +R V C + C +RP
Sbjct: 1004 QEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEA 1063
Query: 1562 TRPCNTHPCT-QWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESS 1620
+ PC CT +W VG W +CS CG G+QRR C+ Q P +D C H P +
Sbjct: 1064 SVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAP-VPADFCQHLPKPVTV 1122
Query: 1621 RPCGTEDC 1628
R C C
Sbjct: 1123 RGCWAGPC 1130
Score = 75.5 bits (184), Expect = 4e-13
Identities = 72/265 (27%), Positives = 96/265 (36%), Gaps = 60/265 (22%)
Query: 1423 CSTTCGLGAVWRPVRCSSGRDEDCAPA----GRPQPA---RRCHLRPCAT-WHSGNWSKC 1474
CS +CG G W C ++ G QP C L PC W G++ C
Sbjct: 695 CSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPC 754
Query: 1475 SRSCGGGSSVRDVQCVDTRD--LRPLRPFHCQPGPAKPP-AHRPCGAQPC-LSWYTSSWR 1530
S SCGGG R V+CV+ + L+ L P C+ G +P A C QPC W S
Sbjct: 755 SASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPS 814
Query: 1531 ECSEACGGGEQQRLVTC------------PEPGLCEEALRPNTTRPCNTHPCT------- 1571
C+ A G G TC PG +E L PC C
Sbjct: 815 SCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKL--PAPEPCVGMSCPPGWGHLD 872
Query: 1572 -----QWVVGPW-----------------GQCSGPCGGGVQRRLVKCVNTQTGLPEEDSD 1609
+ PW G CS CG G+ C+++ +P ++ +
Sbjct: 873 ATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQE-E 931
Query: 1610 QCGHEAWPESSRPCGTEDCEPVEPP 1634
CG + P S R E C+ V P
Sbjct: 932 LCGLASKPGSRR----EVCQAVPCP 952
Score = 74.7 bits (182), Expect = 7e-13
Identities = 77/274 (28%), Positives = 98/274 (35%), Gaps = 63/274 (22%)
Query: 1415 WQAGNWSECSTTCGLGAVWRPVRC--SSGRDEDCAP-----AGRPQPA---RRCHLRPC- 1463
W G++ CS +CG G RPVRC + G P AG QPA C+ +PC
Sbjct: 746 WAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCP 805
Query: 1464 ATWHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPA--KPPAHRPC----- 1516
A W S C+ + G G ++ + CV D P PG K PA PC
Sbjct: 806 ARWEVSEPSSCTSAGGAGLALENETCVPGADGLE-APVTEGPGSVDEKLPAPEPCVGMSC 864
Query: 1517 -------------------------GAQPCLSWYTSSWRECSEACGGGEQQRLVTCPEPG 1551
GAQ W T + CS +CG G + C +
Sbjct: 865 PPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVW-TPAAGSCSVSCGRGLMELRFLCMDSA 923
Query: 1552 --------LCEEALRPNTTRP-CNTHPCTQWVVGPWGQCSGPCGGGVQRRLVKCVNTQTG 1602
LC A +P + R C PC CS CG GV RR++ C
Sbjct: 924 LRVPVQEELCGLASKPGSRREVCQAVPCPARWQYKLAACSVSCGRGVVRRILYCARAH-- 981
Query: 1603 LPEEDSD------QCGHEAWPESSRPCGTEDCEP 1630
E+D + QC PE C E C P
Sbjct: 982 -GEDDGEEILLDTQCQGLPRPEPQEACSLEPCPP 1014
Score = 72.4 bits (176), Expect = 3e-12
Identities = 51/161 (31%), Positives = 66/161 (40%), Gaps = 19/161 (11%)
Query: 1388 VPETQPLAPSLAEAGPPADPLVVRNAGWQAGNWSECSTTCGLGAVWRPVRC---SSGRDE 1444
+P +P E PP W+ + CS +CGLG R V C G+D
Sbjct: 998 LPRPEPQEACSLEPCPPR---------WKVMSLGPCSASCGLGTARRSVACVQLDQGQDV 1048
Query: 1445 D-----CAPAGRPQPARRCHLRPCA-TWHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPL 1498
+ CA RP+ + C + C WH G W +CS SCG G R C+ + P+
Sbjct: 1049 EVDEAACAALVRPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPV 1108
Query: 1499 RPFHCQPGPAKPPAHRPCGAQPCLSWYTSSWRECSEACGGG 1539
CQ P KP R C A PC+ T S EA G
Sbjct: 1109 PADFCQHLP-KPVTVRGCWAGPCVGQGTPSLVPHEEAAAPG 1148
Score = 69.7 bits (169), Expect = 2e-11
Identities = 45/130 (34%), Positives = 60/130 (46%), Gaps = 11/130 (8%)
Query: 810 REAGGHDEVPPPVFSWHYGPWTKCTVTCGRGVQRQNVYCLERQAGP---VDEEHCDPLGR 866
+EA + PP GP C+ +CG G R++V C++ G VDE C L R
Sbjct: 1004 QEACSLEPCPPRWKVMSLGP---CSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVR 1060
Query: 867 PDDQQRKCSEQPCPARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEH 926
P+ C C RW G W CS SCG G + RR C+ G Q+ + C+H
Sbjct: 1061 PEASV-PCLIADCTYRWHVGTWMECSVSCGDG-IQRRRDTCL---GPQAQAPVPADFCQH 1115
Query: 927 LPRPPTETPC 936
LP+P T C
Sbjct: 1116 LPKPVTVRGC 1125
Score = 49.7 bits (117), Expect = 2e-05
Identities = 24/58 (41%), Positives = 32/58 (55%), Gaps = 2/58 (3%)
Query: 823 FSWHYGPWTKCTVTCGRGVQRQNVYCLERQA-GPVDEEHCDPLGRPDDQQRKCSEQPC 879
+ WH G W +C+V+CG G+QR+ CL QA PV + C L +P R C PC
Sbjct: 1074 YRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKP-VTVRGCWAGPC 1130
Score = 48.9 bits (115), Expect = 4e-05
Identities = 31/96 (32%), Positives = 45/96 (46%), Gaps = 11/96 (11%)
Query: 1519 QPCLSWYTSSWR-ECSEACGGGEQQRLVTC--------PEPGLCEEALRPNT-TRPCNTH 1568
+P +W ++ R CS +CG G + +C E C+ + +P C
Sbjct: 681 KPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLE 740
Query: 1569 PCTQ-WVVGPWGQCSGPCGGGVQRRLVKCVNTQTGL 1603
PC W VG +G CS CGGG++ R V+CV Q L
Sbjct: 741 PCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSL 776
Score = 33.1 bits (74), Expect = 2.3
Identities = 28/70 (40%), Positives = 30/70 (42%), Gaps = 13/70 (18%)
Query: 1425 TTCGLGAVWRPVRCSSGRDEDCAPAGRPQPARRCHLRPCATWHS-GNWSKCSRSCGGGSS 1483
T CG+ W CS GR C P H R W S G S CSRSCGGG
Sbjct: 358 TECGVEK-W----CSKGR---CRSLVELTPIAAVHGR----WSSWGPRSPCSRSCGGGVV 405
Query: 1484 VRDVQCVDTR 1493
R QC + R
Sbjct: 406 TRRRQCNNPR 415
>gi|21265043 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 3 preproprotein [Homo sapiens]
Length = 1340
Score = 330 bits (846), Expect = 7e-90
Identities = 257/822 (31%), Positives = 354/822 (43%), Gaps = 93/822 (11%)
Query: 229 RLRRLHQRSVSKEKWVETLVVADAKMVEYHGQPQVESYVLTIMNMVAGLFHDPSIGNPIH 288
R R+ +R+ +E LV + + H Q E YVLT +N+ A L DPS+G
Sbjct: 67 RQRQRQRRAAGGILHLELLVAVGPDVFQAH-QEDTERYVLTNLNIGAELLRDPSLGAQFR 125
Query: 289 ITIVRLVLLEDEEEDLKITHHADNTLKSFCKWQKSINMKGDAHPLHHDTAILLTRKDL-C 347
+ +V++V+L + E IT + ++L S C W ++IN + D P H D + +TR DL
Sbjct: 126 VHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITRFDLEL 185
Query: 348 AAMNRPCETLGLSHVAGMCQPHRSCSINEDTGLPLAFTVAHELGHSFGIQHDGS-GNDCE 406
NR + G++ + G C P SC I EDTG L T+AHE+GHSFG++HDG+ G+ C
Sbjct: 186 PDGNR--QVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGSGCG 243
Query: 407 PVGKRPFIMSPQLLYDAAPLTWSRCSRQYITRFLDRGWGLCLDDPPAKDIIDFPSVPPGV 466
P G +M+ A L WS CSR+ + L
Sbjct: 244 PSGH---VMASDGAAPRAGLAWSPCSRRQLLSLLS------------------------- 275
Query: 467 LYDVSHQCRLQYGAYSAFC----EDMDNVCHTLWCSVG----TTCHSKLDAAVDGTRCGE 518
+ QCR+ +G + C E +D +C L C ++C L +DGT CG
Sbjct: 276 ---ANEQCRVAFGPKAVACTFAREHLD-MCQALSCHTDPLDQSSCSRLLVPLLDGTECGV 331
Query: 519 NKWCLSGECVP-VGFRP-EAVDGGWSGWSAWSICSRSCGMGVQSAERQCTQPTPKYKGRY 576
KWC G C V P AV G WS W S CSRSCG GV + RQC P P + GR
Sbjct: 332 EKWCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRA 391
Query: 577 CVGERKRFRLCNLQACPAGRPSFRHVQCSHFDAMLYK-----GQLHTW---VPVVNDVNP 628
CVG + +CN QAC + F QC+ D + + W VP
Sbjct: 392 CVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDAL 451
Query: 629 CELHCRPANEYFAEKLRDAVVDGTPCYQVRASRD----LCINGICKNVGCDFEIDSGAME 684
C CR E F K D+ +DGT C D LC++G C+ GCD +DS +
Sbjct: 452 CRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVW 511
Query: 685 DRCGVCHGNGSTCHTVSGTFEEAEGLGYVDVGLIPAGAREIRIQEVAEAANFLALRSEDP 744
DRC VC G+ STC G+F YV + + I LA+R
Sbjct: 512 DRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIGG- 570
Query: 745 EKYFLNGGWTIQWNG-----------DYQVAGTTFTYARRGNWENLTSPGPTKEPVWIQL 793
+Y + G +I N +Y+VA T R E + GP +E IQ+
Sbjct: 571 -RYVVAGKMSISPNTTYPSLLEDGRVEYRVA---LTEDRLPRLEEIRIWGPLQEDADIQV 626
Query: 794 LFQESNPGVHYEYTIHREAGGHDEVPPPVFSWHY----GPWTKCTVTCGRGVQRQNVYCL 849
G Y + P P +W + GP C+V+CG G++ N CL
Sbjct: 627 Y---RRYGEEYGNLTRPDITFTYFQPKPRQAWVWAAVRGP---CSVSCGAGLRWVNYSCL 680
Query: 850 ER-QAGPVDEEHCDPLGRPDDQQRKCSEQPCPARWWAGEWQLCSSSCGPGGLSRRAVLCI 908
++ + V+ C +P C +PCP W G++ CS+SCG GGL R V C+
Sbjct: 681 DQARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCG-GGLRERPVRCV 739
Query: 909 RSVGLDEQSALEPPACEHLPRPPTET--PCNRHVPCPATWAVGNWSQCSVTCGEGTQRRN 966
+ G L P C + P CN PCPA W V S C+ G G N
Sbjct: 740 EAQG-SLLKTLPPARCRAGAQQPAVALETCNPQ-PCPARWEVSEPSSCTSAGGAGLALEN 797
Query: 967 VLCT-NDTGVPCDEAQQPASEVTCSLPLCRWPLGTLGPEGSG 1007
C G+ + P S V LP +G P G G
Sbjct: 798 ETCVPGADGLEAPVTEGPGS-VDEKLPAPEPCVGMSCPPGWG 838
Score = 110 bits (274), Expect = 2e-23
Identities = 82/232 (35%), Positives = 112/232 (48%), Gaps = 26/232 (11%)
Query: 830 WT----KCTVTCGRGVQRQNVYCLERQAG-PVDEEHCDPLGRPDDQQRKCSEQPCPARWW 884
WT C+V+CGRG+ C++ PV EE C +P ++ C PCPARW
Sbjct: 866 WTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARW- 924
Query: 885 AGEWQL--CSSSCGPGGLSRRAVLCIRSVGLDE-QSALEPPACEHLPRPPTETPCNRHVP 941
+++L CS SCG G+ RR + C R+ G D+ + L C+ LPRP + C+ P
Sbjct: 925 --QYKLAACSVSCG-RGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLE-P 980
Query: 942 CPATWAVGNWSQCSVTCGEGTQRRNVLCTN-DTG--VPCDEAQ-----QPASEVTCSLPL 993
CP W V + CS +CG GT RR+V C D G V DEA +P + V C +
Sbjct: 981 CPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIAD 1040
Query: 994 C--RWPLGTLGPEGSGSGSSSHELFNEADFIPHHLAPRPSPASS--PKPGTM 1041
C RW +GT E S S + + P AP P+ PKP T+
Sbjct: 1041 CTYRWHVGT-WMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTV 1091
Score = 106 bits (265), Expect = 2e-22
Identities = 77/211 (36%), Positives = 95/211 (45%), Gaps = 26/211 (12%)
Query: 788 PVWIQLLFQESNPGVHYEYTIHREAGGHDEVPPPVFSWHYGPWTKCTVTCGRGVQRQNVY 847
PV +L S PG E VP P W Y C+V+CGRGV R+ +Y
Sbjct: 896 PVQEELCGLASKPGSRREVC--------QAVPCPA-RWQY-KLAACSVSCGRGVVRRILY 945
Query: 848 CLERQAGPVDEE-----HCDPLGRPDDQQRKCSEQPCPARWWAGEWQLCSSSCGPGGLSR 902
C EE C L RP+ Q+ CS +PCP RW CS+SCG G +R
Sbjct: 946 CARAHGEDDGEEILLDTQCQGLPRPEPQEA-CSLEPCPPRWKVMSLGPCSASCGLG-TAR 1003
Query: 903 RAVLCIRSVGLDEQSALE--PPACEHLPRPPTETPCNRHVPCPATWAVGNWSQCSVTCGE 960
R+V C++ LD+ +E AC L RP PC C W VG W +CSV+CG+
Sbjct: 1004 RSVACVQ---LDQGQDVEVDEAACAALVRPEASVPC-LIADCTYRWHVGTWMECSVSCGD 1059
Query: 961 GTQRRNVLCTN---DTGVPCDEAQQPASEVT 988
G QRR C VP D Q VT
Sbjct: 1060 GIQRRRDTCLGPQAQAPVPADFCQHLPKPVT 1090
Score = 94.4 bits (233), Expect = 9e-19
Identities = 77/261 (29%), Positives = 101/261 (38%), Gaps = 35/261 (13%)
Query: 1410 VRNAGWQAGNWS----ECSTTCGLGAVWRPVRCSSG------RDEDCAPAGRPQPARR-C 1458
+R A W+ CS +CG G + C ++E C A +P R C
Sbjct: 856 IRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVC 915
Query: 1459 HLRPCATWHSGNWSKCSRSCGGGSSVRDVQCV------DTRDLRPLRPFHCQPGPAKPPA 1512
PC + CS SCG G R + C D ++ L CQ G +P
Sbjct: 916 QAVPCPARWQYKLAACSVSCGRGVVRRILYCARAHGEDDGEEI--LLDTQCQ-GLPRPEP 972
Query: 1513 HRPCGAQPCLS-WYTSSWRECSEACGGGEQQRLVTCPE----------PGLCEEALRPNT 1561
C +PC W S CS +CG G +R V C + C +RP
Sbjct: 973 QEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEA 1032
Query: 1562 TRPCNTHPCT-QWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESS 1620
+ PC CT +W VG W +CS CG G+QRR C+ Q P +D C H P +
Sbjct: 1033 SVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAP-VPADFCQHLPKPVTV 1091
Query: 1621 RPCGTEDCEPVEPPRCERDRL 1641
R C C V C R L
Sbjct: 1092 RGCWAGPC--VGQGACGRQHL 1110
Score = 75.5 bits (184), Expect = 4e-13
Identities = 72/265 (27%), Positives = 96/265 (36%), Gaps = 60/265 (22%)
Query: 1423 CSTTCGLGAVWRPVRCSSGRDEDCAPA----GRPQPA---RRCHLRPCAT-WHSGNWSKC 1474
CS +CG G W C ++ G QP C L PC W G++ C
Sbjct: 664 CSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPC 723
Query: 1475 SRSCGGGSSVRDVQCVDTRD--LRPLRPFHCQPGPAKPP-AHRPCGAQPC-LSWYTSSWR 1530
S SCGGG R V+CV+ + L+ L P C+ G +P A C QPC W S
Sbjct: 724 SASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPS 783
Query: 1531 ECSEACGGGEQQRLVTC------------PEPGLCEEALRPNTTRPCNTHPCT------- 1571
C+ A G G TC PG +E L PC C
Sbjct: 784 SCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKL--PAPEPCVGMSCPPGWGHLD 841
Query: 1572 -----QWVVGPW-----------------GQCSGPCGGGVQRRLVKCVNTQTGLPEEDSD 1609
+ PW G CS CG G+ C+++ +P ++ +
Sbjct: 842 ATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQE-E 900
Query: 1610 QCGHEAWPESSRPCGTEDCEPVEPP 1634
CG + P S R E C+ V P
Sbjct: 901 LCGLASKPGSRR----EVCQAVPCP 921
Score = 74.7 bits (182), Expect = 7e-13
Identities = 77/274 (28%), Positives = 98/274 (35%), Gaps = 63/274 (22%)
Query: 1415 WQAGNWSECSTTCGLGAVWRPVRC--SSGRDEDCAP-----AGRPQPA---RRCHLRPC- 1463
W G++ CS +CG G RPVRC + G P AG QPA C+ +PC
Sbjct: 715 WAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCP 774
Query: 1464 ATWHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPA--KPPAHRPC----- 1516
A W S C+ + G G ++ + CV D P PG K PA PC
Sbjct: 775 ARWEVSEPSSCTSAGGAGLALENETCVPGADGLE-APVTEGPGSVDEKLPAPEPCVGMSC 833
Query: 1517 -------------------------GAQPCLSWYTSSWRECSEACGGGEQQRLVTCPEPG 1551
GAQ W T + CS +CG G + C +
Sbjct: 834 PPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVW-TPAAGSCSVSCGRGLMELRFLCMDSA 892
Query: 1552 --------LCEEALRPNTTRP-CNTHPCTQWVVGPWGQCSGPCGGGVQRRLVKCVNTQTG 1602
LC A +P + R C PC CS CG GV RR++ C
Sbjct: 893 LRVPVQEELCGLASKPGSRREVCQAVPCPARWQYKLAACSVSCGRGVVRRILYCARAH-- 950
Query: 1603 LPEEDSD------QCGHEAWPESSRPCGTEDCEP 1630
E+D + QC PE C E C P
Sbjct: 951 -GEDDGEEILLDTQCQGLPRPEPQEACSLEPCPP 983
Score = 70.1 bits (170), Expect = 2e-11
Identities = 49/143 (34%), Positives = 64/143 (44%), Gaps = 12/143 (8%)
Query: 810 REAGGHDEVPPPVFSWHYGPWTKCTVTCGRGVQRQNVYCLERQAGP---VDEEHCDPLGR 866
+EA + PP GP C+ +CG G R++V C++ G VDE C L R
Sbjct: 973 QEACSLEPCPPRWKVMSLGP---CSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVR 1029
Query: 867 PDDQQRKCSEQPCPARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEH 926
P+ C C RW G W CS SCG G + RR C+ G Q+ + C+H
Sbjct: 1030 PEASV-PCLIADCTYRWHVGTWMECSVSCGDG-IQRRRDTCL---GPQAQAPVPADFCQH 1084
Query: 927 LPRPPTETPCNRHVPCPATWAVG 949
LP+P T C PC A G
Sbjct: 1085 LPKPVTVRGCWAG-PCVGQGACG 1106
Score = 50.4 bits (119), Expect = 1e-05
Identities = 26/69 (37%), Positives = 35/69 (50%), Gaps = 2/69 (2%)
Query: 823 FSWHYGPWTKCTVTCGRGVQRQNVYCLERQA-GPVDEEHCDPLGRPDDQQRKCSEQPCPA 881
+ WH G W +C+V+CG G+QR+ CL QA PV + C L +P R C PC
Sbjct: 1043 YRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKP-VTVRGCWAGPCVG 1101
Query: 882 RWWAGEWQL 890
+ G L
Sbjct: 1102 QGACGRQHL 1110
Score = 48.9 bits (115), Expect = 4e-05
Identities = 31/96 (32%), Positives = 45/96 (46%), Gaps = 11/96 (11%)
Query: 1519 QPCLSWYTSSWR-ECSEACGGGEQQRLVTC--------PEPGLCEEALRPNT-TRPCNTH 1568
+P +W ++ R CS +CG G + +C E C+ + +P C
Sbjct: 650 KPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLE 709
Query: 1569 PCTQ-WVVGPWGQCSGPCGGGVQRRLVKCVNTQTGL 1603
PC W VG +G CS CGGG++ R V+CV Q L
Sbjct: 710 PCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSL 745
Score = 33.1 bits (74), Expect = 2.3
Identities = 28/70 (40%), Positives = 30/70 (42%), Gaps = 13/70 (18%)
Query: 1425 TTCGLGAVWRPVRCSSGRDEDCAPAGRPQPARRCHLRPCATWHS-GNWSKCSRSCGGGSS 1483
T CG+ W CS GR C P H R W S G S CSRSCGGG
Sbjct: 327 TECGVEK-W----CSKGR---CRSLVELTPIAAVHGR----WSSWGPRSPCSRSCGGGVV 374
Query: 1484 VRDVQCVDTR 1493
R QC + R
Sbjct: 375 TRRRQCNNPR 384
>gi|145309328 papilin [Homo sapiens]
Length = 1251
Score = 308 bits (788), Expect = 4e-83
Identities = 181/481 (37%), Positives = 241/481 (50%), Gaps = 61/481 (12%)
Query: 541 WSGWSAWSICSRSCGMGVQSAERQCTQPTPKYKGRYCVGERKRFRLCNLQACPAGRPSFR 600
W WS WS CSR+CG GV ER C + G CVG + R C ++CP G FR
Sbjct: 29 WGPWSQWSPCSRTCGGGVSFRERPCYSQR-RDGGSSCVGPARSHRSCRTESCPDGARDFR 87
Query: 601 HVQCSHFDAMLYKGQLHTWVPVVNDVNPCELHCRPANEYFAEKLRDAVVDGTPCYQVRAS 660
QC+ FD ++G+ + W+P + N CEL+C P E F K R+AVVDGTPC
Sbjct: 88 AEQCAEFDGAEFQGRRYRWLPYYSAPNKCELNCIPKGENFYYKHREAVVDGTPCEP--GK 145
Query: 661 RDLCINGICKNVGCDFEIDSGAMEDRCGVCHGNGSTCHTVSGTFEEAEGLGYVDVGLIPA 720
RD+C++G C+ VGCD E+DS ED+C C G+G+TC+ V+GTF D +
Sbjct: 146 RDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTTCYPVAGTF---------DANDLSR 196
Query: 721 GAREIRIQEVAEAANFLALRSEDPEKYFLNGGWTIQWNGDYQVAGTTFTYARRGNW---- 776
+ +R +Y+LNG WTI+ A T Y R
Sbjct: 197 AVKNVR------------------GEYYLNGHWTIEAARALPAASTILHYERGAEGDLAP 238
Query: 777 ENLTSPGPTKEPVWIQLLFQESNPGVHYEYTIHREAGGHDEVPPPVFSWHYGPWTKCTVT 836
E L + GPT EP+ I+L+ QE NPGVHYEY + P P FSW +G W+ C+
Sbjct: 239 ERLHARGPTSEPLVIELISQEPNPGVHYEYHLPLRR------PSPGFSWSHGSWSDCSAE 292
Query: 837 CGRGVQRQNVYC-LERQAGPVDEEHCDPLGRPDDQQRKCSEQPCP--ARWWAGEWQLCSS 893
CG G Q + V+C ++ +A P + C RP D +R C+ PCP RW AG W CS+
Sbjct: 293 CGGGHQSRLVFCTIDHEAYP--DHMCQRQPRPAD-RRSCNLHPCPETKRWKAGPWAPCSA 349
Query: 894 SCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLP-RPPTETPCNRHVPCPATWAVGNWS 952
SCG GG R+V CI S G Q A+E C LP +PP CN + A W+ W
Sbjct: 350 SCG-GGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACN--LQRCAAWSPEPWG 406
Query: 953 QCSVTCGEGTQRRNVLCTNDTG-----VPCDEAQQPASEVTCSLPLC------RWPLGTL 1001
+CSV+CG G ++R+V C + G C +P C C W +GT
Sbjct: 407 ECSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCVHEDCPLLSDQAWHVGTW 466
Query: 1002 G 1002
G
Sbjct: 467 G 467
Score = 145 bits (365), Expect = 4e-34
Identities = 99/290 (34%), Positives = 119/290 (41%), Gaps = 56/290 (19%)
Query: 1394 LAPSLAEA-GPPADPLVVR------NAG-----------------WQAGNWSECSTTCGL 1429
LAP A GP ++PLV+ N G W G+WS+CS CG
Sbjct: 236 LAPERLHARGPTSEPLVIELISQEPNPGVHYEYHLPLRRPSPGFSWSHGSWSDCSAECGG 295
Query: 1430 GAVWRPVRCSSGR----DEDCAPAGRPQPARRCHLRPCAT---WHSGNWSKCSRSCGGGS 1482
G R V C+ D C RP R C+L PC W +G W+ CS SCGGGS
Sbjct: 296 GHQSRLVFCTIDHEAYPDHMCQRQPRPADRRSCNLHPCPETKRWKAGPWAPCSASCGGGS 355
Query: 1483 SVRDVQCVDTRDL---RPLRPFHCQPGPAKPPAHRPCGAQPCLSWYTSSWRECSEACGGG 1539
R V C+ + + C P KPPA + C Q C +W W ECS +CG G
Sbjct: 356 QSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRCAAWSPEPWGECSVSCGVG 415
Query: 1540 EQQRLVTCP-------EPGLCEEALRPNTTRPCNTHPC-----TQWVVGPWGQCSGPCGG 1587
++R VTC C RP T PC C W VG WG CS C
Sbjct: 416 VRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCVHEDCPLLSDQAWHVGTWGLCSKSCSS 475
Query: 1588 GVQRRLVKCVNTQTGLPEEDSDQCG--HEAWPESSRPCGTEDCE-PVEPP 1634
G +RR V C G P CG + P PC T+ C P E P
Sbjct: 476 GTRRRQVICA---IGPP----SHCGSLQHSKPVDVEPCNTQPCHLPQEVP 518
Score = 36.6 bits (83), Expect = 0.21
Identities = 23/62 (37%), Positives = 28/62 (45%), Gaps = 7/62 (11%)
Query: 1461 RPCATWHS-GNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAHRPCGAQ 1519
R TW WS CSR+CGGG S R+ C R GPA+ +HR C +
Sbjct: 24 RQSDTWGPWSQWSPCSRTCGGGVSFRERPCYSQR----RDGGSSCVGPAR--SHRSCRTE 77
Query: 1520 PC 1521
C
Sbjct: 78 SC 79
Score = 34.3 bits (77), Expect = 1.1
Identities = 39/151 (25%), Positives = 57/151 (37%), Gaps = 18/151 (11%)
Query: 460 PSVPPGVLYDVSHQCRLQYGAYSAFCEDMDNVCHTLWCSVGT-----TCHSKLDAAVDGT 514
P PP + C LQ A A+ + C ++ C VG TC + + +
Sbjct: 383 PGKPPAI-----QACNLQRCA--AWSPEPWGEC-SVSCGVGVRKRSVTCRGERGSLLHTA 434
Query: 515 RCG-ENKWCLSGECVPVGFRPEAVDGGWSGWSAWSICSRSCGMGVQSAERQCTQPTPKYK 573
C E++ L+ CV P D W W +CS+SC G + + C P +
Sbjct: 435 ACSLEDRPPLTEPCVHEDC-PLLSDQAWHV-GTWGLCSKSCSSGTRRRQVICAIGPPSHC 492
Query: 574 GRYCVGERKRFRLCNLQAC--PAGRPSFRHV 602
G + CN Q C P PS + V
Sbjct: 493 GSLQHSKPVDVEPCNTQPCHLPQEVPSMQDV 523
Score = 33.9 bits (76), Expect = 1.4
Identities = 29/88 (32%), Positives = 35/88 (39%), Gaps = 20/88 (22%)
Query: 1544 LVTCPEPGLCEEALRPNTTRPCNTHPCTQWVVGPWGQ---CSGPCGGGVQRRLVKCVNTQ 1600
L+ P PG + P R +T W GPW Q CS CGGGV R C + +
Sbjct: 9 LLLAPAPG----SSAPKVRRQSDT-----W--GPWSQWSPCSRTCGGGVSFRERPCYSQR 57
Query: 1601 TGLPEEDSDQCGHEAWPESSRPCGTEDC 1628
+ C A S R C TE C
Sbjct: 58 ----RDGGSSCVGPA--RSHRSCRTESC 79
Score = 33.1 bits (74), Expect = 2.3
Identities = 24/74 (32%), Positives = 29/74 (39%), Gaps = 4/74 (5%)
Query: 1394 LAPSLAEAGPPADPLVVRNAGWQAGNWSE---CSTTCGLGAVWRPVRC-SSGRDEDCAPA 1449
L P L P + VR G WS+ CS TCG G +R C S RD +
Sbjct: 6 LVPLLLAPAPGSSAPKVRRQSDTWGPWSQWSPCSRTCGGGVSFRERPCYSQRRDGGSSCV 65
Query: 1450 GRPQPARRCHLRPC 1463
G + R C C
Sbjct: 66 GPARSHRSCRTESC 79
>gi|38016904 thrombospondin repeat containing 1 isoform 1 [Homo
sapiens]
Length = 1074
Score = 263 bits (672), Expect = 1e-69
Identities = 165/485 (34%), Positives = 225/485 (46%), Gaps = 74/485 (15%)
Query: 577 CVGERKRFRLCNLQACPAGRPSFRHVQCSHFDAMLYKGQLHTWVPV--VNDVNPCELHCR 634
C GE ++ R C+ CP +P R +QC+ F++ + GQL+ W P V CEL+CR
Sbjct: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQWEPFTEVQGSQRCELNCR 423
Query: 635 PANEYFAEKLRDAVVDGTPCYQVRASRDLCINGICKNVGCDFEIDSGAMEDRCGVCHGNG 694
P F + + V DGT C + D+C+ G C + GCD + SG D CGVC G+
Sbjct: 424 PRGFRFYVRHTEKVQDGTLCQP--GAPDICVAGRCLSPGCDGILGSGRRPDGCGVCGGDD 481
Query: 695 STCHTVSGTFEEAEG-LGYVDVGLIPAGAREIRIQEVAEAANFLALRSEDPEKYFLNGGW 753
STC VSG + G LGY + IPAGA ++I ++ ++N+LALR + +NG W
Sbjct: 482 STCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPG-GRSIINGNW 540
Query: 754 TIQWNGDYQVAGTTFTYAR----RGNWENLTSPGPTKEPVWIQLLFQESNPGVHYEY--- 806
+ G Y+ GT F Y R G E+L++ GPT +PV + ++FQE NPGV Y+Y
Sbjct: 541 AVDPPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMIFQEENPGVFYQYVIS 600
Query: 807 ----------------------------------------TIHRE-------AGGHDEVP 819
T+ R+ A H P
Sbjct: 601 SPPPILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQRQVRIPQMPAPPHPRTP 660
Query: 820 --PPVFSWHYGPWTKCTVTCGRGVQRQNVYCLERQAG-PVDEEHCDPLGRPDDQQRKCSE 876
P W + C+ +CG+GV R C+ R++G +DE C RP C
Sbjct: 661 LGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHG 720
Query: 877 QPCPARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPC 936
PCP W AGEW CS SCGP G R + C + G S++ P C HLPRP C
Sbjct: 721 TPCPPYWEAGEWTSCSRSCGP-GTQHRQLQCRQEFG-GGGSSVPPERCGHLPRPNITQSC 778
Query: 937 NRHVPCPATWAVGN-WSQCSVTCGEGTQRRNVLCTNDTGVPCDEAQ------QPASEVTC 989
+ C W VG+ WSQCSV CG G + R V C + G E + QP S C
Sbjct: 779 QLRL-C-GHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREAC 836
Query: 990 SLPLC 994
+ C
Sbjct: 837 DMGPC 841
Score = 152 bits (384), Expect = 3e-36
Identities = 113/377 (29%), Positives = 146/377 (38%), Gaps = 55/377 (14%)
Query: 1294 PPPIAPLPEMKVRDSSLEPGTPSFPTPG--PGSWDLQTVAVWGTFLPTTLTGLGHMPEPA 1351
P P P+P+++ +EP P P PG+ Q + MP P
Sbjct: 609 PTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQRQV-------------RIPQMPAPP 655
Query: 1352 LNPGPKGQPESLSPEVPLS--SRLLSTPAWDSP--ANSHRVPETQPLAPSLAEAGPPADP 1407
P G P + V S S W S E A A PPA P
Sbjct: 656 HPRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASP 715
Query: 1408 LVVRNAG----WQAGNWSECSTTCGLGAVWRPVRC--------SSGRDEDCAPAGRPQPA 1455
W+AG W+ CS +CG G R ++C SS E C RP
Sbjct: 716 EPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNIT 775
Query: 1456 RRCHLRPCATWHSGN-WSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAHR 1514
+ C LR C W G+ WS+CS CG G R V+CV + C GP +PP+
Sbjct: 776 QSCQLRLCGHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNG-DEVSEQECASGPPQPPSRE 834
Query: 1515 PCGAQPCLS-WYTSSWR-ECSEACGGGEQQRLVTCPEPGL----------------CEEA 1556
C PC + W+ S W +CS CG G Q+R V C G C
Sbjct: 835 ACDMGPCTTAWFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTG 894
Query: 1557 LRPNTTRPCNTHPCTQ---WVVGPWGQCSGPCGGGVQRRLVKCVN-TQTGLPEEDSDQCG 1612
RP R C+ PC + W GPWG+CS CG G QRR + CV+ T C
Sbjct: 895 SRPPDMRACSLGPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCS 954
Query: 1613 HEAWPESSRPCGTEDCE 1629
H P + +PC + C+
Sbjct: 955 HLPRPPALQPCQGQACQ 971
Score = 150 bits (379), Expect = 1e-35
Identities = 96/288 (33%), Positives = 125/288 (43%), Gaps = 43/288 (14%)
Query: 1415 WQAGN-WSECSTTCGLGAVWRPVRCSSGR-----DEDCAPAGRPQPARR--CHLRPCAT- 1465
W+ G+ WS+CS CG G R VRC +++CA +G PQP R C + PC T
Sbjct: 786 WEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECA-SGPPQPPSREACDMGPCTTA 844
Query: 1466 WHSGNWS-KCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGP---------AKPPAHRP 1515
W +WS KCS CG G R V C+ + L P + G ++PP R
Sbjct: 845 WFHSDWSSKCSAECGTGIQRRSVVCLGSG--AALGPGQGEAGAGTGQSCPTGSRPPDMRA 902
Query: 1516 CGAQPC---LSWYTSSWRECSEACGGGEQQRLVTC----------PEPGLCEEALRPNTT 1562
C PC WYT W ECS CG G Q+R + C P C RP
Sbjct: 903 CSLGPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPAL 962
Query: 1563 RPCNTHPCT-QWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSR 1621
+PC C +W PW CS C GG Q R V+C++T L S +C + P R
Sbjct: 963 QPCQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQTL----STRCPPQLRPSRKR 1018
Query: 1622 PCGTEDCEPVEPPRCERDRLSFGFCETLRLLGRCQLPTIRTQCCRSCS 1669
PC ++ C +C+ S C + C P CCRSC+
Sbjct: 1019 PCNSQPCSQRPDDQCKD---SSPHCPLVVQARLCVYPYYTATCCRSCA 1063
Score = 118 bits (295), Expect = 6e-26
Identities = 77/228 (33%), Positives = 99/228 (43%), Gaps = 39/228 (17%)
Query: 1401 AGPPADP------LVVRNAGWQAGNWS-ECSTTCGLGAVWRPVRC--------------S 1439
+GPP P + W +WS +CS CG G R V C
Sbjct: 825 SGPPQPPSREACDMGPCTTAWFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAG 884
Query: 1440 SGRDEDCAPAGRPQPARRCHLRPCAT---WHSGNWSKCSRSCGGGSSVRDVQCVDT--RD 1494
+G + C RP R C L PC W++G W +CS CG G+ RD+ CV +
Sbjct: 885 AGTGQSCPTGSRPPDMRACSLGPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTE 944
Query: 1495 LRPLRPFHCQPGPAKPPAHRPCGAQPCLS-WYTSSWRECSEACGGGEQQRLVTCPEPG-- 1551
P +C P +PPA +PC Q C W+++ W CS +C GG Q R V C
Sbjct: 945 FNVTSPSNCSHLP-RPPALQPCQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQT 1003
Query: 1552 ---LCEEALRPNTTRPCNTHPCTQWVVGPWGQC---SGPCGGGVQRRL 1593
C LRP+ RPCN+ PC+Q P QC S C VQ RL
Sbjct: 1004 LSTRCPPQLRPSRKRPCNSQPCSQ---RPDDQCKDSSPHCPLVVQARL 1048
Score = 116 bits (290), Expect = 2e-25
Identities = 69/193 (35%), Positives = 92/193 (47%), Gaps = 19/193 (9%)
Query: 817 EVPPPVFSWHYGPWT-KCTVTCGRGVQRQNVYCL---------ERQAGPVDEEHCDPLGR 866
++ P +W + W+ KC+ CG G+QR++V CL + +AG + C R
Sbjct: 837 DMGPCTTAWFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSR 896
Query: 867 PDDQQRKCSEQPCPA--RWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPAC 924
P D R CS PC RW+ G W CSS CG G RR ++C+ +G E + P C
Sbjct: 897 PPDM-RACSLGPCERTWRWYTGPWGECSSECG-SGTQRRDIICVSKLGT-EFNVTSPSNC 953
Query: 925 EHLPRPPTETPCNRHVPCPATWAVGNWSQCSVTCGEGTQRRNVLC--TNDT-GVPCDEAQ 981
HLPRPP PC C W WS CS +C GTQ R V C TN T C
Sbjct: 954 SHLPRPPALQPCQGQA-CQDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQTLSTRCPPQL 1012
Query: 982 QPASEVTCSLPLC 994
+P+ + C+ C
Sbjct: 1013 RPSRKRPCNSQPC 1025
Score = 105 bits (262), Expect = 4e-22
Identities = 64/192 (33%), Positives = 88/192 (45%), Gaps = 23/192 (11%)
Query: 825 WHYG-PWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRK-CSEQPCPAR 882
W G PW++C+V CGRG + + V C+ V E+ C G P R+ C PC
Sbjct: 786 WEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQEC-ASGPPQPPSREACDMGPCTTA 844
Query: 883 WWAGEW-QLCSSSCGPGGLSRRAVLCIRS-----VGLDEQSALEPPACEHLPRPPTETPC 936
W+ +W CS+ CG G+ RR+V+C+ S G E A +C RPP C
Sbjct: 845 WFHSDWSSKCSAECGT-GIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMRAC 903
Query: 937 NRHVPCPATWA--VGNWSQCSVTCGEGTQRRNVLCTNDTGVP--------CDEAQQPASE 986
+ PC TW G W +CS CG GTQRR+++C + G C +P +
Sbjct: 904 SLG-PCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPAL 962
Query: 987 VTCSLPLC--RW 996
C C RW
Sbjct: 963 QPCQGQACQDRW 974
Score = 41.6 bits (96), Expect = 0.007
Identities = 15/32 (46%), Positives = 19/32 (59%)
Query: 538 DGGWSGWSAWSICSRSCGMGVQSAERQCTQPT 569
+G W W W+ CS+ CG+GVQ R C PT
Sbjct: 44 EGVWGPWVQWASCSQPCGVGVQRRSRTCQLPT 75
Score = 36.6 bits (83), Expect = 0.21
Identities = 21/63 (33%), Positives = 27/63 (42%), Gaps = 2/63 (3%)
Query: 1569 PCTQWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESS-RPCGTED 1627
P W CS CG GV R + C++ ++G E D C A P +S PC
Sbjct: 664 PAAYWKRVGHSACSASCGKGVWRPIFLCISRESG-EELDERSCAAGARPPASPEPCHGTP 722
Query: 1628 CEP 1630
C P
Sbjct: 723 CPP 725
Score = 35.0 bits (79), Expect = 0.62
Identities = 31/93 (33%), Positives = 36/93 (38%), Gaps = 29/93 (31%)
Query: 496 WCSVGTTCHSKLDAAVDGTRCGENKW-----CLSGEC--------VPVGFRPEAVDGGWS 542
W VG HS A+ CG+ W C+S E G RP A
Sbjct: 668 WKRVG---HSACSAS-----CGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCH 719
Query: 543 G------WSA--WSICSRSCGMGVQSAERQCTQ 567
G W A W+ CSRSCG G Q + QC Q
Sbjct: 720 GTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQ 752
Score = 33.9 bits (76), Expect = 1.4
Identities = 22/57 (38%), Positives = 30/57 (52%), Gaps = 4/57 (7%)
Query: 1544 LVTCPEPGLCEEALRPNTTR-PCNTHPCTQWVVGPWGQ---CSGPCGGGVQRRLVKC 1596
L++ P+ L +E L ++ + P + V GPW Q CS PCG GVQRR C
Sbjct: 15 LLSLPQLCLDQEVLSGHSLQTPTEEGQGPEGVWGPWVQWASCSQPCGVGVQRRSRTC 71
Score = 33.5 bits (75), Expect = 1.8
Identities = 20/48 (41%), Positives = 23/48 (47%), Gaps = 3/48 (6%)
Query: 547 WSICSRSCGMGVQSAERQCTQPTPKYKGRYCVGERK--RFRLCNLQAC 592
WS CSRSC G Q+ E QC R C + + R R CN Q C
Sbjct: 979 WSPCSRSCQGGTQTREVQCLSTNQTLSTR-CPPQLRPSRKRPCNSQPC 1025
>gi|56788359 thrombospondin repeat containing 1 isoform 2 [Homo
sapiens]
Length = 877
Score = 263 bits (672), Expect = 1e-69
Identities = 165/485 (34%), Positives = 225/485 (46%), Gaps = 74/485 (15%)
Query: 577 CVGERKRFRLCNLQACPAGRPSFRHVQCSHFDAMLYKGQLHTWVPV--VNDVNPCELHCR 634
C GE ++ R C+ CP +P R +QC+ F++ + GQL+ W P V CEL+CR
Sbjct: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQWEPFTEVQGSQRCELNCR 423
Query: 635 PANEYFAEKLRDAVVDGTPCYQVRASRDLCINGICKNVGCDFEIDSGAMEDRCGVCHGNG 694
P F + + V DGT C + D+C+ G C + GCD + SG D CGVC G+
Sbjct: 424 PRGFRFYVRHTEKVQDGTLCQP--GAPDICVAGRCLSPGCDGILGSGRRPDGCGVCGGDD 481
Query: 695 STCHTVSGTFEEAEG-LGYVDVGLIPAGAREIRIQEVAEAANFLALRSEDPEKYFLNGGW 753
STC VSG + G LGY + IPAGA ++I ++ ++N+LALR + +NG W
Sbjct: 482 STCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPG-GRSIINGNW 540
Query: 754 TIQWNGDYQVAGTTFTYAR----RGNWENLTSPGPTKEPVWIQLLFQESNPGVHYEY--- 806
+ G Y+ GT F Y R G E+L++ GPT +PV + ++FQE NPGV Y+Y
Sbjct: 541 AVDPPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMIFQEENPGVFYQYVIS 600
Query: 807 ----------------------------------------TIHRE-------AGGHDEVP 819
T+ R+ A H P
Sbjct: 601 SPPPILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQRQVRIPQMPAPPHPRTP 660
Query: 820 --PPVFSWHYGPWTKCTVTCGRGVQRQNVYCLERQAG-PVDEEHCDPLGRPDDQQRKCSE 876
P W + C+ +CG+GV R C+ R++G +DE C RP C
Sbjct: 661 LGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHG 720
Query: 877 QPCPARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPC 936
PCP W AGEW CS SCGP G R + C + G S++ P C HLPRP C
Sbjct: 721 TPCPPYWEAGEWTSCSRSCGP-GTQHRQLQCRQEFG-GGGSSVPPERCGHLPRPNITQSC 778
Query: 937 NRHVPCPATWAVGN-WSQCSVTCGEGTQRRNVLCTNDTGVPCDEAQ------QPASEVTC 989
+ C W VG+ WSQCSV CG G + R V C + G E + QP S C
Sbjct: 779 QLRL-C-GHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREAC 836
Query: 990 SLPLC 994
+ C
Sbjct: 837 DMGPC 841
Score = 102 bits (253), Expect = 4e-21
Identities = 81/258 (31%), Positives = 105/258 (40%), Gaps = 33/258 (12%)
Query: 1348 PEPALNPGPKGQPESLSPEVPLSSRLLSTPAWDSPANSHRVPETQPLAPSLAEAGPPADP 1407
PEP P P+ QPE L E PL+ PA PA + + Q P + P P
Sbjct: 611 PEP---PVPQLQPEILRVEPPLA------PA-PRPARTPGTLQRQVRIPQMPAPPHPRTP 660
Query: 1408 LVVRNAGWQAGNWSECSTTCGLGAVWRPVRCSSGRDE-------DCAPAGRPQPARR-CH 1459
L A W+ S CS +CG G VWRP+ R+ CA RP + CH
Sbjct: 661 LGSPAAYWKRVGHSACSASCGKG-VWRPIFLCISRESGEELDERSCAAGARPPASPEPCH 719
Query: 1460 LRPCAT-WHSGNWSKCSRSCGGGSSVRDVQCVDT--RDLRPLRPFHCQPGPAKPPAHRPC 1516
PC W +G W+ CSRSCG G+ R +QC + P C P +P + C
Sbjct: 720 GTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLP-RPNITQSC 778
Query: 1517 GAQPCLSWYTSS-WRECSEACGGGEQQRLVTC--------PEPGLCEEALRPNTTRPCNT 1567
+ C W S W +CS CG G++ R V C E +P + C+
Sbjct: 779 QLRLCGHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDM 838
Query: 1568 HPC-TQWVVGPWGQCSGP 1584
PC T W W P
Sbjct: 839 GPCTTAWFHSDWSSKVSP 856
Score = 95.1 bits (235), Expect = 5e-19
Identities = 94/366 (25%), Positives = 122/366 (33%), Gaps = 67/366 (18%)
Query: 1299 PLPEMKVRDSSLEPGTPSFPTPGPGSWDLQTVAVWGTFLPTTLTGLGHMPEPALNPGPKG 1358
P ++++ + L P + GPG + W P + G + P +G
Sbjct: 507 PAGALRLQIAQLRPSSNYLALRGPGGRSIIN-GNWAVDPPGSYRAGGTVFRYNRPPREEG 565
Query: 1359 QPESLSPEVPLSSRL--------------------LSTPAWDSPANSHRVPETQP----L 1394
+ ESLS E P + + P ++P VP+ QP +
Sbjct: 566 KGESLSAEGPTTQPVDVYMIFQEENPGVFYQYVISSPPPILENPTPEPPVPQLQPEILRV 625
Query: 1395 APSLAEAGPPADPLVVRNAGWQAGNWSECSTTCGLGAVWRPVRCSSGRDEDCAPAGRPQP 1454
P LA A PA G + R VR PA P
Sbjct: 626 EPPLAPAPRPARTP---------------------GTLQRQVRIPQ------MPA--PPH 656
Query: 1455 ARRCHLRPCATWHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAHR 1514
R P A W S CS SCG G C+ L C G P +
Sbjct: 657 PRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPE 716
Query: 1515 PCGAQPCLS-WYTSSWRECSEACGGGEQQRLVTCPE----------PGLCEEALRPNTTR 1563
PC PC W W CS +CG G Q R + C + P C RPN T+
Sbjct: 717 PCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQ 776
Query: 1564 PCNTHPCTQWVVG-PWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRP 1622
C C W VG PW QCS CG G + R V+CV G + + P S
Sbjct: 777 SCQLRLCGHWEVGSPWSQCSVRCGRGQRSRQVRCVG-NNGDEVSEQECASGPPQPPSREA 835
Query: 1623 CGTEDC 1628
C C
Sbjct: 836 CDMGPC 841
Score = 92.4 bits (228), Expect = 3e-18
Identities = 74/256 (28%), Positives = 96/256 (37%), Gaps = 34/256 (13%)
Query: 1294 PPPIAPLPEMKVRDSSLEPGTPSFPTPG--PGSWDLQTVAVWGTFLPTTLTGLGHMPEPA 1351
P P P+P+++ +EP P P PG+ Q + MP P
Sbjct: 609 PTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQRQ-------------VRIPQMPAPP 655
Query: 1352 LNPGPKGQPESLSPEVPLS--SRLLSTPAWDS--PANSHRVPETQPLAPSLAEAGPPADP 1407
P G P + V S S W S E A A PPA P
Sbjct: 656 HPRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASP 715
Query: 1408 LVVRNAG----WQAGNWSECSTTCGLGAVWRPVRC--------SSGRDEDCAPAGRPQPA 1455
W+AG W+ CS +CG G R ++C SS E C RP
Sbjct: 716 EPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNIT 775
Query: 1456 RRCHLRPCATWHSGN-WSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAHR 1514
+ C LR C W G+ WS+CS CG G R V+CV + C GP +PP+
Sbjct: 776 QSCQLRLCGHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNG-DEVSEQECASGPPQPPSRE 834
Query: 1515 PCGAQPC-LSWYTSSW 1529
C PC +W+ S W
Sbjct: 835 ACDMGPCTTAWFHSDW 850
Score = 51.2 bits (121), Expect = 8e-06
Identities = 31/96 (32%), Positives = 43/96 (44%), Gaps = 9/96 (9%)
Query: 825 WHYG-PWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRK-CSEQPCPAR 882
W G PW++C+V CGRG + + V C+ V E+ C G P R+ C PC
Sbjct: 786 WEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQEC-ASGPPQPPSREACDMGPCTTA 844
Query: 883 WWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSA 918
W+ +W SS P A+ CI + SA
Sbjct: 845 WFHSDW---SSKVSP---EPPAISCILGNHAQDTSA 874
Score = 41.6 bits (96), Expect = 0.007
Identities = 15/32 (46%), Positives = 19/32 (59%)
Query: 538 DGGWSGWSAWSICSRSCGMGVQSAERQCTQPT 569
+G W W W+ CS+ CG+GVQ R C PT
Sbjct: 44 EGVWGPWVQWASCSQPCGVGVQRRSRTCQLPT 75
Score = 36.6 bits (83), Expect = 0.21
Identities = 21/63 (33%), Positives = 27/63 (42%), Gaps = 2/63 (3%)
Query: 1569 PCTQWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESS-RPCGTED 1627
P W CS CG GV R + C++ ++G E D C A P +S PC
Sbjct: 664 PAAYWKRVGHSACSASCGKGVWRPIFLCISRESG-EELDERSCAAGARPPASPEPCHGTP 722
Query: 1628 CEP 1630
C P
Sbjct: 723 CPP 725
Score = 35.0 bits (79), Expect = 0.62
Identities = 31/93 (33%), Positives = 36/93 (38%), Gaps = 29/93 (31%)
Query: 496 WCSVGTTCHSKLDAAVDGTRCGENKW-----CLSGEC--------VPVGFRPEAVDGGWS 542
W VG HS A+ CG+ W C+S E G RP A
Sbjct: 668 WKRVG---HSACSAS-----CGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCH 719
Query: 543 G------WSA--WSICSRSCGMGVQSAERQCTQ 567
G W A W+ CSRSCG G Q + QC Q
Sbjct: 720 GTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQ 752
Score = 33.9 bits (76), Expect = 1.4
Identities = 22/57 (38%), Positives = 30/57 (52%), Gaps = 4/57 (7%)
Query: 1544 LVTCPEPGLCEEALRPNTTR-PCNTHPCTQWVVGPWGQ---CSGPCGGGVQRRLVKC 1596
L++ P+ L +E L ++ + P + V GPW Q CS PCG GVQRR C
Sbjct: 15 LLSLPQLCLDQEVLSGHSLQTPTEEGQGPEGVWGPWVQWASCSQPCGVGVQRRSRTC 71
>gi|11038659 ADAM metallopeptidase with thrombospondin type 1 motif,
2 isoform 2 [Homo sapiens]
Length = 566
Score = 239 bits (610), Expect = 2e-62
Identities = 183/574 (31%), Positives = 263/574 (45%), Gaps = 66/574 (11%)
Query: 2 PGGPSPRSPAPLLRPLLLLLCA-LAPGAPGPA----------PGRATEGRAALDIVHPVR 50
P G + R P L LLLLL L P P PA PG A + PVR
Sbjct: 4 PAGAARRLLCPALLLLLLLLPPPLLPPPPPPANARLAAAADPPGGPLGHGAERILAVPVR 63
Query: 51 VDAGGSFLSYELWPRALRKRDVSVRRDAPA-----------------FYELQYRGRELRF 93
DA G +S+ + A + V RR AP FY + GR+L
Sbjct: 64 TDAQGRLVSHVV-SAATSRAGVRARRAAPVRTPSFPGGNEEEPGSHLFYNVTVFGRDLHL 122
Query: 94 NLTANQHLLAPGFVSETRRRGGLGRAHIRAHTPACHLLGEVQDPELEGGLAAISACDGLK 153
L N L+APG E + G G + +C +G+V E A+S CDGL
Sbjct: 123 RLRPNARLVAPGATMEWQ--GEKGTTRVEPLLGSCLYVGDVAGLA-EASSVALSNCDGLA 179
Query: 154 GVFQLSNEDYFIEPLDS--APARPGHAQPHVVYKRQAPERLAQRGDSSAPSTCGVQVYPE 211
G+ ++ E++FIEPL+ A + HVVY+R P G A T G +
Sbjct: 180 GLIRMEEEEFFIEPLEKGLAAQEAEQGRVHVVYRR--PPTSPPLGGPQALDT-GASL-DS 235
Query: 212 LESRRERWEQRQQWRRPRLRRLHQRSVSKEKWVETLVVADAKMVEYHGQPQVESYVLTIM 271
L+S ++ RR + + + +E L+ D +V++HG+ V+ Y+LT+M
Sbjct: 236 LDSLSRALGVLEEHANSSRRRARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLM 295
Query: 272 NMVAGLFHDPSIGNPIHITIVRLVLLE-DEEEDLKITHHADNTLKSFCKWQKSINMKGDA 330
N+V ++HD S+G I++ +VR++LL + L + +L++ C+W
Sbjct: 296 NIVNEIYHDESLGAHINVVLVRIILLSYGKSMSLIEIGNPSQSLENVCRWAYLQQKPDTG 355
Query: 331 HPLHHDTAILLTRKDLCAAMNRPCETLGLSHVAGMCQPHRSCSINEDTGLPLAFTVAHEL 390
H +HD AI LTR+D P G + V GMC P RSC++N + G AF VAHE
Sbjct: 356 HDEYHDHAIFLTRQDF-----GPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHET 410
Query: 391 GHSFGIQHDGSGNDCEPVGKRPFIMSPQLLYDAAPLTWSRCSRQYITRFLDRGWGLCLDD 450
GH G++HDG GN C + IM+P + WSRCS+Q ++R+L + LDD
Sbjct: 411 GHVLGMEHDGQGNRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELSRYL-HSYDCLLDD 469
Query: 451 PPAKDIIDFPSVP--PGVLYDVSHQCRLQYGAYSAFCEDMD--NVCHTLWCSVGTT---C 503
P A D+P++P PG+ Y ++ QCR +G C + C LWCS C
Sbjct: 470 PFAH---DWPALPQLPGLHYSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSHPDNPYFC 526
Query: 504 HSKLDAAVDGTRCGENKWCLSGECVPVGFRPEAV 537
+K +DGT C K FRP AV
Sbjct: 527 KTKKGPPLDGTMCAPGK-----------FRPGAV 549
>gi|94536854 thrombospondin, type I, domain containing 4 [Homo
sapiens]
Length = 1018
Score = 232 bits (592), Expect = 2e-60
Identities = 162/489 (33%), Positives = 228/489 (46%), Gaps = 50/489 (10%)
Query: 551 SRSCGMGVQSAERQCTQPTPKYKGRYCVGERKRFRLCNLQACPAGRPSFRHVQCSHFDAM 610
S + G+G A + +QP + C+G ++++LCN CP S R VQC+ ++
Sbjct: 266 SNNHGVGTHGATQSFSQPA-RSTAISCIGAYRQYKLCNTNVCPESSRSIREVQCASYNNK 324
Query: 611 LYKGQLHTWVPV--VNDVNPCELHCRPANEYFAEKLRDAVVDGTPCYQVRASRDLCINGI 668
+ G+ + W P V CEL+C+ F + + V+DGTPC Q + +C++G
Sbjct: 325 PFMGRFYEWEPFAEVKGNRKCELNCQAMGYRFYVRQAEKVIDGTPCDQNGTA--ICVSGQ 382
Query: 669 CKNVGCDFEIDSGAMEDRCGVCHGNGSTCHTVSGTFEEA-EGLGYVDVGLIPAGAREIRI 727
CK++GCD + S + D+CGVC G+ + C VSG F+ A LGY V IP GA +I I
Sbjct: 383 CKSIGCDDYLGSDKVVDKCGVCGGDNTGCQVVSGVFKHALTSLGYHRVVEIPEGATKINI 442
Query: 728 QEVAEAANFLALRSEDPEKYFLNGGWTIQWNGDYQVAGTTFTYARRGN-----WENLTSP 782
E+ ++ N+LALRS + +NG W I G Y+ GT FTY R E+ +
Sbjct: 443 TEMYKSNNYLALRSRS-GRSIINGNWAIDRPGKYEGGGTMFTYKRPNEISSTAGESFLAE 501
Query: 783 GPTKEPVWIQLLFQESNPGVHYEYTIHREAGGHDEVPPPVFSWHYGPWTKCTVTCGR--- 839
GPT E + + ++ Q+ NPGVHYEY I +VPP P+ VT GR
Sbjct: 502 GPTNEILDVYMIHQQPNPGVHYEYVIMGTNAISPQVPPHRRPGE--PFNGQMVTEGRSQE 559
Query: 840 -GVQRQNVYCLERQAGPVDE------------EHCDPLG--RPDDQQRKCSEQPCPAR-- 882
G Q+ E G E H D RPD+ + P +R
Sbjct: 560 EGEQKGRNEEKEDLRGEAPEMFTSESAQTFPVRHPDRFSPHRPDNLVPPAPQPPRRSRDH 619
Query: 883 -WWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRP-PTETPCNRHV 940
W CS++CG G R V C+ +P P E PCN
Sbjct: 620 NWKQLGTTECSTTCGKGS----QYPIFRCVHRSTHEEAPESYCDSSMKPTPEEEPCN-IF 674
Query: 941 PCPATWAVGNWSQCSVTCGEGTQRRNVLC------TNDTGVP--CDEAQQPASEVTCSLP 992
PCPA W +G WS+CS TCG G Q R VLC + T P C ++P + TC L
Sbjct: 675 PCPAFWDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPETTSTCQLK 734
Query: 993 LC-RWPLGT 1000
+C W + T
Sbjct: 735 ICSEWQIRT 743
Score = 139 bits (349), Expect = 3e-32
Identities = 88/277 (31%), Positives = 119/277 (42%), Gaps = 32/277 (11%)
Query: 1415 WQAG-NWSECSTTCGLGAVWRPVRCSSG-----RDEDCAPAGRPQPARRCHLRPCA-TWH 1467
WQ +W+ CS CG+G R V+C S DE+C RP C + PCA +W
Sbjct: 739 WQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKLRPNDIENCDMGPCAKSWF 798
Query: 1468 SGNWS-KCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAHRPCGAQPC---LS 1523
WS +CS CG G R V C+ T + L C G +P PC PC +
Sbjct: 799 LTEWSERCSAECGAGVRTRSVVCM-TNHVSSLPLEGC--GNNRPAEATPCDNGPCTGKVE 855
Query: 1524 WYTSSWRECSEACGGGEQQRLVTCP----------EPGLCEEALRPNTTRPCNTHPC-TQ 1572
W+ SW +CS CG G QQR V C +P C +P + + C+ PC +
Sbjct: 856 WFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKPCGAK 915
Query: 1573 WVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPCGTEDCEPVE 1632
W W CS C GG + R V+C++ L S+ C + PE C +DC P
Sbjct: 916 WFSTEWSMCSKSCQGGFRVREVRCLSDDMTL----SNLCDPQLKPEERESCNPQDCVPEV 971
Query: 1633 PPRCERDRLSFGFCETLRLLGRCQLPTIRTQCCRSCS 1669
C+ + RL C +T CC SC+
Sbjct: 972 DENCKDKYYNCNVVVQARL---CVYNYYKTACCASCT 1005
Score = 120 bits (302), Expect = 9e-27
Identities = 95/306 (31%), Positives = 126/306 (41%), Gaps = 32/306 (10%)
Query: 1345 GHMPEPALNPGPKGQPESLSPEVPLSSRLLSTPAWDSPANSHRVPET-QPLAPSLAEAGP 1403
G E G + E L E P S A P R P+ P P
Sbjct: 555 GRSQEEGEQKGRNEEKEDLRGEAP--EMFTSESAQTFPV---RHPDRFSPHRPDNLVPPA 609
Query: 1404 PADPLVVRNAGWQAGNWSECSTTCGLGAVWRPVRC------SSGRDEDCAPAGRPQPARR 1457
P P R+ W+ +ECSTTCG G+ + RC + C + +P P
Sbjct: 610 PQPPRRSRDHNWKQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPTPEEE 669
Query: 1458 -CHLRPC-ATWHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPL--RPFHCQPGPAKPPAH 1513
C++ PC A W G WS+CS++CG G R V C R L +P+ CQ KP
Sbjct: 670 PCNIFPCPAFWDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQ-HLEKPETT 728
Query: 1514 RPCGAQPCLSW-YTSSWRECSEACGGGEQQRLVTC-------PEPGLCEEALRPNTTRPC 1565
C + C W + W CS CG G++ R V C + C LRPN C
Sbjct: 729 STCQLKICSEWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKLRPNDIENC 788
Query: 1566 NTHPCTQ-WVVGPWGQ-CSGPCGGGVQRRLVKCV-NTQTGLPEEDSDQCGHEAWPESSRP 1622
+ PC + W + W + CS CG GV+ R V C+ N + LP E CG+ P + P
Sbjct: 789 DMGPCAKSWFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEG---CGNNR-PAEATP 844
Query: 1623 CGTEDC 1628
C C
Sbjct: 845 CDNGPC 850
Score = 107 bits (267), Expect = 1e-22
Identities = 61/176 (34%), Positives = 89/176 (50%), Gaps = 19/176 (10%)
Query: 830 WTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQPCPARWWAGEW- 888
WT C+V CG G + ++V C+ VD+E C+ RP+D + C PC W+ EW
Sbjct: 745 WTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKLRPNDIEN-CDMGPCAKSWFLTEWS 803
Query: 889 QLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPCNRHVPCPAT--W 946
+ CS+ CG G+ R+V+C+ + S+L C + RP TPC+ PC W
Sbjct: 804 ERCSAECG-AGVRTRSVVCMTN----HVSSLPLEGCGN-NRPAEATPCDNG-PCTGKVEW 856
Query: 947 AVGNWSQCSVTCGEGTQRRNVLCTNDTG--------VPCDEAQQPASEVTCSLPLC 994
G+WSQCS+ CG GTQ+R V+C C ++P S+ +C L C
Sbjct: 857 FAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKPC 912
Score = 105 bits (261), Expect = 5e-22
Identities = 54/159 (33%), Positives = 81/159 (50%), Gaps = 4/159 (2%)
Query: 824 SWHYGPWTKCTVTCGRGVQRQNVYCLERQAGP-VDEEHCDPLGRPDDQQRKCSEQPCPAR 882
+W T+C+ TCG+G Q C+ R E +CD +P ++ C+ PCPA
Sbjct: 620 NWKQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPTPEEEPCNIFPCPAF 679
Query: 883 WWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPCNRHVPC 942
W GEW CS +CG G+ R VLC R V + ++P C+HL +P T + C + C
Sbjct: 680 WDIGEWSECSKTCGL-GMQHRQVLC-RQVYANRSLTVQPYRCQHLEKPETTSTCQLKI-C 736
Query: 943 PATWAVGNWSQCSVTCGEGTQRRNVLCTNDTGVPCDEAQ 981
+W+ CSV CG G + R+V C ++ G D+ +
Sbjct: 737 SEWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEE 775
Score = 100 bits (249), Expect = 1e-20
Identities = 58/184 (31%), Positives = 85/184 (46%), Gaps = 11/184 (5%)
Query: 817 EVPPPVFSWHYGPWT-KCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCS 875
++ P SW W+ +C+ CG GV+ ++V C+ + E C RP + C
Sbjct: 789 DMGPCAKSWFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEGCGN-NRPAEAT-PCD 846
Query: 876 EQPCPAR--WWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTE 933
PC + W+AG W CS CG G +R V+C+R D L+P C L +PP++
Sbjct: 847 NGPCTGKVEWFAGSWSQCSIECG-SGTQQREVICVRK-NADTFEVLDPSECSFLEKPPSQ 904
Query: 934 TPCNRHVPCPATWAVGNWSQCSVTCGEGTQRRNVLCTND---TGVPCDEAQQPASEVTCS 990
C+ PC A W WS CS +C G + R V C +D CD +P +C+
Sbjct: 905 QSCHLK-PCGAKWFSTEWSMCSKSCQGGFRVREVRCLSDDMTLSNLCDPQLKPEERESCN 963
Query: 991 LPLC 994
C
Sbjct: 964 PQDC 967
Score = 81.6 bits (200), Expect = 6e-15
Identities = 53/156 (33%), Positives = 70/156 (44%), Gaps = 15/156 (9%)
Query: 1399 AEAGPPADPLVVRNAGWQAGNWSECSTTCGLGAVWRPVRCSSGRDE--------DCAPAG 1450
AEA P + W AG+WS+CS CG G R V C + +C+
Sbjct: 840 AEATPCDNGPCTGKVEWFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLE 899
Query: 1451 RPQPARRCHLRPC-ATWHSGNWSKCSRSCGGGSSVRDVQCV-DTRDLRPLRPFHCQPGPA 1508
+P + CHL+PC A W S WS CS+SC GG VR+V+C+ D L L C P
Sbjct: 900 KPPSQQSCHLKPCGAKWFSTEWSMCSKSCQGGFRVREVRCLSDDMTLSNL----CDP-QL 954
Query: 1509 KPPAHRPCGAQPCLSWYTSSWRECSEACGGGEQQRL 1544
KP C Q C+ + ++ C Q RL
Sbjct: 955 KPEERESCNPQDCVPEVDENCKDKYYNCNVVVQARL 990
Score = 39.3 bits (90), Expect = 0.033
Identities = 15/36 (41%), Positives = 18/36 (50%)
Query: 539 GGWSGWSAWSICSRSCGMGVQSAERQCTQPTPKYKG 574
G W W WS CSRSC GV R C + + +G
Sbjct: 54 GVWGAWGPWSACSRSCSGGVMEQTRPCLPRSYRLRG 89
>gi|145275198 ADAMTS-like 3 precursor [Homo sapiens]
Length = 1691
Score = 231 bits (590), Expect = 3e-60
Identities = 147/464 (31%), Positives = 209/464 (45%), Gaps = 49/464 (10%)
Query: 535 EAVDGGWSGWSAWSICSRSCGMGVQSAERQCTQPTPKYKGRYCVGERKRFRLCNLQACPA 594
E DG W W WS CSR+CG G + R+C GR C G+ R++ C+ CP
Sbjct: 72 EDKDGNWDAWGDWSDCSRTCGGGASYSLRRCLT------GRNCEGQNIRYKTCSNHDCPP 125
Query: 595 GRPSFRHVQCSHFDAMLYKGQLHTWVPVVND-VNPCELHCRPANEYFAEKLRDAVVDGTP 653
FR QCS ++ + Y+G + W+P ND PC L C + +L V+DGT
Sbjct: 126 DAEDFRAQQCSAYNDVQYQGHYYEWLPRYNDPAAPCALKCHAQGQNLVVELAPKVLDGTR 185
Query: 654 CYQVRASRDLCINGICKNVGCDFEIDSGAMEDRCGVCHGNGSTCHTVSGTFEE--AEGLG 711
C S D+CI+GIC+ VGCD ++ S A ED CGVC G+GSTC V G + +
Sbjct: 186 CNT--DSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSPEKR 243
Query: 712 YVDVGLIPAGAREIRIQEVAEAANFLALRSEDPEKYFLNGGWTIQWNGDYQVAGTTFTYA 771
+V +P G+R +RI A F+ ++ K G + G + V TT +
Sbjct: 244 EENVIAVPLGSRSVRITVKGPAHLFIESKTLQGSK----GEHSFNSPGVFLVENTTVEFQ 299
Query: 772 RRGNWENLTSPGPTKEPVWIQLLFQESNPGVHYEYTIHREAGGHDEVPPPVFSWHYGPWT 831
R + PGP + + + V ++ ++ P W +
Sbjct: 300 RGSERQTFKIPGPLMADFIFKTRYTAAKDSV-VQFFFYQ---------PISHQWRQTDFF 349
Query: 832 KCTVTCGRGVQRQNVYCLE-RQAGPVDEEHCDPLG---RPDDQQRKCSEQPCPA------ 881
CTVTCG G Q + C++ R V + +C +P + ++CS PCP+
Sbjct: 350 PCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPCPSSDGFKE 409
Query: 882 -----------RWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRP 930
RW W CS SCG GG+ RR+ +C+ E +E C + P+P
Sbjct: 410 IMPYDHFQPLPRWEHNPWTACSVSCG-GGIQRRSFVCVEESMHGEILQVEEWKCMYAPKP 468
Query: 931 PTETPCNRHVPCPATWAVGNWSQCSVTCGEGTQRRNVLCTNDTG 974
CN CP W WSQC+VTCG G + R VLC N G
Sbjct: 469 KVMQTCNL-FDCP-KWIAMEWSQCTVTCGRGLRYRVVLCINHRG 510
Score = 129 bits (323), Expect = 3e-29
Identities = 89/285 (31%), Positives = 125/285 (43%), Gaps = 37/285 (12%)
Query: 1403 PPADPLVVRNAGWQAGNWSECSTTCG-LGAVWRPVRCSSGRDED-----CAPAGRPQPA- 1455
PP +P W+ GNWS CS TCG LGA + +C ++ C +P
Sbjct: 1422 PPQEPF------WEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPLAGF 1475
Query: 1456 RRCHLRPC-ATWHSGNWSKCSRSCGGGSSVRDVQCVDTR---DLRPLRPFHCQPGPAKPP 1511
C++R C A W + WS+CS SCG G R V C T+ ++ + P C P +P
Sbjct: 1476 EPCNIRDCPARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKD-RPL 1534
Query: 1512 AHRPCGAQPCLSWYTSSWRECSEACGGGE---QQRLVTCPEPGL---CEEALRPNTTRPC 1565
+PC PC+ W + C C G QQR C C++ RP R C
Sbjct: 1535 GRKPCFGHPCVQWEPGN--RCPGRCMGRAVRMQQRHTACQHNSSDSNCDDRKRPTLRRNC 1592
Query: 1566 NTHPCTQ-WVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPCG 1624
+ C W GPW C+ CG G Q R V C++T++ P C + P S R C
Sbjct: 1593 TSGACDVCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVA-KRHCVQKKKPISWRHC- 1650
Query: 1625 TEDCEPVEPPRCERDRL-SFGFCETLRLLGRCQLPTIRTQCCRSC 1668
P C+RD + +C ++ L C L + +CC+SC
Sbjct: 1651 -------LGPSCDRDCTDTTHYCMFVKHLNLCSLDRYKQRCCQSC 1688
Score = 108 bits (271), Expect = 3e-23
Identities = 65/175 (37%), Positives = 85/175 (48%), Gaps = 12/175 (6%)
Query: 825 WHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQPCPARWW 884
WH G W C+ TCG G+Q ++VYCL P E C +P Q C++ CP W
Sbjct: 707 WHVGSWGPCSATCGVGIQTRDVYCLHPGETPAPPEECRD-EKPHALQ-ACNQFDCPPGWH 764
Query: 885 AGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPCNRHVPCPA 944
EWQ CS +CG GG R V C + + L C+ P+ + C R CP
Sbjct: 765 IEEWQQCSRTCG-GGTQNRRVTCRQLLTDGSFLNLSDELCQG-PKASSHKSCAR-TDCPP 821
Query: 945 TWAVGNWSQCSVTCGEGTQRRNVLCTNDTGVPCDEAQQPASEVTC----SLPLCR 995
AVG+WS+CSV+CG G QRR +C + + P SE+ C LPL R
Sbjct: 822 HLAVGDWSKCSVSCGVGIQRRKQVCQR---LAAKGRRIPLSEMMCRDLPGLPLVR 873
Score = 104 bits (260), Expect = 6e-22
Identities = 54/148 (36%), Positives = 71/148 (47%), Gaps = 8/148 (5%)
Query: 823 FSWHYGPWTKCTVTCGRGVQRQNVYCLERQA-GPVDEEHCDPLGRPDDQQRKCSEQPCPA 881
+ W Y +T CT TC G Q CL Q V++ CD + RP + C+ +PCP
Sbjct: 646 YDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPP 705
Query: 882 RWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPCNRHVP 941
RW G W CS++CG G+ R V C+ ++ P C +P CN+
Sbjct: 706 RWHVGSWGPCSATCGV-GIQTRDVYCLH----PGETPAPPEECRD-EKPHALQACNQ-FD 758
Query: 942 CPATWAVGNWSQCSVTCGEGTQRRNVLC 969
CP W + W QCS TCG GTQ R V C
Sbjct: 759 CPPGWHIEEWQQCSRTCGGGTQNRRVTC 786
Score = 101 bits (252), Expect = 5e-21
Identities = 82/289 (28%), Positives = 112/289 (38%), Gaps = 82/289 (28%)
Query: 1415 WQAGNWSECSTTCGLGAVWRPVRCSSGRDEDCAPAGRPQPARRCHLR-------PC---- 1463
W A WS+C+ TCG G +R V C + R E G P + H++ PC
Sbjct: 482 WIAMEWSQCTVTCGRGLRYRVVLCINHRGEH---VGGCNPQLKLHIKEECVIPIPCYKPK 538
Query: 1464 ---------------------------ATWHSGNWSKCSRSCGGGSSVRDVQC----VDT 1492
T+ WS CS +CG G VR+V+C T
Sbjct: 539 EKSPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCRVLLTFT 598
Query: 1493 RDLRPLRPFHCQPGPAKPPAHRPCGAQPC--------------------LSWYTSSWREC 1532
+ L C+ GP K P RPC + C W + + C
Sbjct: 599 QTETELPEEECE-GP-KLPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPC 656
Query: 1533 SEACGGGEQQRLVTC--------PEPGLCEEALRPNT-TRPCNTHPCT-QWVVGPWGQCS 1582
+ C GG Q+ + C LC+ RP ++ CNT PC +W VG WG CS
Sbjct: 657 TATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPRWHVGSWGPCS 716
Query: 1583 GPCGGGVQRRLVKCVNT-QTGLPEEDSDQCGHEAWPESSRPCGTEDCEP 1630
CG G+Q R V C++ +T P E +C E P + + C DC P
Sbjct: 717 ATCGVGIQTRDVYCLHPGETPAPPE---ECRDEK-PHALQACNQFDCPP 761
Score = 100 bits (250), Expect = 9e-21
Identities = 76/282 (26%), Positives = 112/282 (39%), Gaps = 36/282 (12%)
Query: 1347 MPEP----ALNPGPKGQPESLSPEVPLSSRLLSTPAWDSPANSHRVPETQPLAPSLAEAG 1402
+PEP + GP Q + V L+ T + ++P +P +
Sbjct: 569 IPEPWSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLPTERPCLLEACDES 628
Query: 1403 PPADPLVV-------RNAGWQAGNWSECSTTCGLGAVWRPVRC------SSGRDEDCAPA 1449
P + L + W+ ++ C+ TC G C + D C
Sbjct: 629 PASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMV 688
Query: 1450 GRPQP-ARRCHLRPCAT-WHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGP 1507
RP ++ C+ PC WH G+W CS +CG G RDV C+ + P P C+
Sbjct: 689 HRPPAMSQACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCLHPGET-PAPPEECRD-- 745
Query: 1508 AKPPAHRPCGAQPCL-SWYTSSWRECSEACGGGEQQRLVTCPE-----------PGLCEE 1555
KP A + C C W+ W++CS CGGG Q R VTC + LC +
Sbjct: 746 EKPHALQACNQFDCPPGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELC-Q 804
Query: 1556 ALRPNTTRPCNTHPC-TQWVVGPWGQCSGPCGGGVQRRLVKC 1596
+ ++ + C C VG W +CS CG G+QRR C
Sbjct: 805 GPKASSHKSCARTDCPPHLAVGDWSKCSVSCGVGIQRRKQVC 846
Score = 95.1 bits (235), Expect = 5e-19
Identities = 64/194 (32%), Positives = 83/194 (42%), Gaps = 12/194 (6%)
Query: 817 EVPPPVFSWHYGPWTKCTVTCGR-GVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCS 875
E PP W G W+ C+ TCG G + Q C+ V E CD L +P C+
Sbjct: 1420 EPPPQEPFWEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPLAGFEPCN 1479
Query: 876 EQPCPARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETP 935
+ CPARW+ W CS SCG G SR+ V C R+ + P AC RP P
Sbjct: 1480 IRDCPARWFTSVWSQCSVSCGEGYHSRQ-VTCKRTKANGTVQVVSPRACAPKDRPLGRKP 1538
Query: 936 CNRHVPCPATWAVGNWSQCSVTC---GEGTQRRNVLCT-NDTGVPCDEAQQPASEVTCSL 991
C H PC W GN +C C Q+R+ C N + CD+ ++P C+
Sbjct: 1539 CFGH-PC-VQWEPGN--RCPGRCMGRAVRMQQRHTACQHNSSDSNCDDRKRPTLRRNCTS 1594
Query: 992 PLCR--WPLGTLGP 1003
C W G P
Sbjct: 1595 GACDVCWHTGPWKP 1608
Score = 91.3 bits (225), Expect = 7e-18
Identities = 49/165 (29%), Positives = 71/165 (43%), Gaps = 32/165 (19%)
Query: 1466 WHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQ--PGPAKP-PAHRPCGAQPCL 1522
W ++ C+ +CGGG + +CVD R R + +C P KP P + C PC
Sbjct: 343 WRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPCP 402
Query: 1523 S------------------WYTSSWRECSEACGGGEQQRLVTCPEPGL-----------C 1553
S W + W CS +CGGG Q+R C E + C
Sbjct: 403 SSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKC 462
Query: 1554 EEALRPNTTRPCNTHPCTQWVVGPWGQCSGPCGGGVQRRLVKCVN 1598
A +P + CN C +W+ W QC+ CG G++ R+V C+N
Sbjct: 463 MYAPKPKVMQTCNLFDCPKWIAMEWSQCTVTCGRGLRYRVVLCIN 507
Score = 87.4 bits (215), Expect = 1e-16
Identities = 73/289 (25%), Positives = 103/289 (35%), Gaps = 79/289 (27%)
Query: 1415 WQAGNWSECSTTCGLGAVWRPVRCSSGRDEDCAPAG---------RPQPA-RRCHLRPCA 1464
W+ ++ C+ TCG G C R + P +P+P + C + PC
Sbjct: 343 WRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPCP 402
Query: 1465 T------------------WHSGNWSKCSRSCGGGSSVRDVQCVDTR---DLRPLRPFHC 1503
+ W W+ CS SCGGG R CV+ ++ + + C
Sbjct: 403 SSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKC 462
Query: 1504 QPGPAKPPAHRPCGAQPCLSWYTSSWRECSEACGGGEQQRLVTC-----PEPGLCEEALR 1558
P KP + C C W W +C+ CG G + R+V C G C L+
Sbjct: 463 MYAP-KPKVMQTCNLFDCPKWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLK 521
Query: 1559 PNTTRPCNTH-PCTQ-------------------------------WVVGPWGQCSGPCG 1586
+ C PC + ++ PW CS CG
Sbjct: 522 LHIKEECVIPIPCYKPKEKSPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCG 581
Query: 1587 GGVQRRLVKC------VNTQTGLPEEDSDQCGHEAWPESSRPCGTEDCE 1629
GVQ R VKC T+T LPEE +C P + RPC E C+
Sbjct: 582 PGVQVREVKCRVLLTFTQTETELPEE---ECEGPKLP-TERPCLLEACD 626
Score = 80.1 bits (196), Expect = 2e-14
Identities = 49/177 (27%), Positives = 74/177 (41%), Gaps = 28/177 (15%)
Query: 829 PWTKCTVTCGRGVQRQNVYC-----LERQAGPVDEEHCDPLGRPDDQQ---RKCSEQPCP 880
PW+ C+ TCG GVQ + V C + + EE C+ P ++ C E P
Sbjct: 572 PWSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLPTERPCLLEACDESPAS 631
Query: 881 AR--------------WWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEH 926
W + C+++C GG +C+ + Q + C+
Sbjct: 632 RELDIPLPEDSETTYDWEYAGFTPCTATC-VGGHQEAIAVCLH---IQTQQTVNDSLCDM 687
Query: 927 LPRPPTETPCNRHVPCPATWAVGNWSQCSVTCGEGTQRRNVLCTN--DTGVPCDEAQ 981
+ RPP + PCP W VG+W CS TCG G Q R+V C + +T P +E +
Sbjct: 688 VHRPPAMSQACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCLHPGETPAPPEECR 744
Score = 79.3 bits (194), Expect = 3e-14
Identities = 72/286 (25%), Positives = 97/286 (33%), Gaps = 72/286 (25%)
Query: 1415 WQAGNWSECSTTCGLGAVWRPVRCSSG---------RDEDCAPAGRPQPARRCHLRPCAT 1465
W+ W+ CS +CG G R C + C A +P+ + C+L C
Sbjct: 422 WEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAPKPKVMQTCNLFDCPK 481
Query: 1466 WHSGNWSKCSRSCGGGSSVRDVQCVDTR-----DLRPLRPFHCQPGPAKP-PAHRPCGAQ 1519
W + WS+C+ +CG G R V C++ R P H + P P ++P
Sbjct: 482 WIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKPKEKS 541
Query: 1520 PC---LSWYTSS-------------------WRECSEACGGGEQQRLVTC---------- 1547
P L W + W CS CG G Q R V C
Sbjct: 542 PVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQTE 601
Query: 1548 ---PEPGLCEEALRPNTTRPCNTHPCTQ--------------------WVVGPWGQCSGP 1584
PE CE P T RPC C + W + C+
Sbjct: 602 TELPEEE-CEGPKLP-TERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTAT 659
Query: 1585 CGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPCGTEDCEP 1630
C GG Q + C++ QT DS P S+ C TE C P
Sbjct: 660 CVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPP 705
Score = 48.5 bits (114), Expect = 5e-05
Identities = 20/44 (45%), Positives = 24/44 (54%), Gaps = 1/44 (2%)
Query: 825 WHYGPWTKCTVTCGRGVQRQNVYCLE-RQAGPVDEEHCDPLGRP 867
WH GPW CT CGRG Q + V C+ R PV + HC +P
Sbjct: 1601 WHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKP 1644
Score = 43.9 bits (102), Expect = 0.001
Identities = 29/93 (31%), Positives = 44/93 (47%), Gaps = 11/93 (11%)
Query: 821 PVFSWHYGPWTKCTVTC-GRGV--QRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQ 877
P W P +C C GR V Q+++ C + + +CD RP +R C+
Sbjct: 1543 PCVQWE--PGNRCPGRCMGRAVRMQQRHTACQHNSS----DSNCDDRKRPT-LRRNCTSG 1595
Query: 878 PCPARWWAGEWQLCSSSCGPGGLSRRAVLCIRS 910
C W G W+ C+++CG G SR+ V CI +
Sbjct: 1596 ACDVCWHTGPWKPCTAACGRGFQSRK-VDCIHT 1627
Score = 39.3 bits (90), Expect = 0.033
Identities = 21/62 (33%), Positives = 30/62 (48%), Gaps = 14/62 (22%)
Query: 1411 RNAGWQA-GNWSECSTTCGLGAVWRPVRCSSGR-------------DEDCAPAGRPQPAR 1456
++ W A G+WS+CS TCG GA + RC +GR + DC P A+
Sbjct: 74 KDGNWDAWGDWSDCSRTCGGGASYSLRRCLTGRNCEGQNIRYKTCSNHDCPPDAEDFRAQ 133
Query: 1457 RC 1458
+C
Sbjct: 134 QC 135
Score = 39.3 bits (90), Expect = 0.033
Identities = 84/363 (23%), Positives = 123/363 (33%), Gaps = 85/363 (23%)
Query: 547 WSICSRSCGMGVQSAERQC------TQPTPKYKGRYCVGER-KRFRLCNLQAC---PAGR 596
WS CS +CG GVQ E +C TQ + C G + R C L+AC PA R
Sbjct: 573 WSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLPTERPCLLEACDESPASR 632
Query: 597 PSFRHVQCSHFDAMLYKGQLHTWVPVVNDVNPCELHCRPANEYFAEKLRDAVVDGTPCYQ 656
D L + T+ PC C ++ +A+ C
Sbjct: 633 ---------ELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQ-------EAI---AVCLH 673
Query: 657 VRASRDLCINGICKNVGCDFEIDSGAMEDRCGV--CH-----GNGSTCHTVSGTFEEAEG 709
++ + + + CD AM C C G+ C G +
Sbjct: 674 IQTQQTV------NDSLCDMVHRPPAMSQACNTEPCPPRWHVGSWGPCSATCGVGIQTRD 727
Query: 710 LGYVDVGLIPAGAREIRIQE--VAEAANFLALRSEDPEKYFLNGGWTI-QWNGDYQVAGT 766
+ + G PA E R ++ +A N ++ GW I +W + G
Sbjct: 728 VYCLHPGETPAPPEECRDEKPHALQACN----------QFDCPPGWHIEEWQQCSRTCG- 776
Query: 767 TFTYARRGNWENLTSPGPTKEPVWIQLLFQESNPGVHYEYTIHREAGGH-----DEVPPP 821
G +N + QLL S + E +A H + PP
Sbjct: 777 -------GGTQN-------RRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDCPPH 822
Query: 822 VFSWHYGPWTKCTVTCGRGVQRQNVYCLERQAG----PVDEEHCDPL-GRPDDQQRKCSE 876
+ G W+KC+V+CG G+QR+ C A P+ E C L G P R C
Sbjct: 823 L---AVGDWSKCSVSCGVGIQRRKQVCQRLAAKGRRIPLSEMMCRDLPGLP--LVRSCQM 877
Query: 877 QPC 879
C
Sbjct: 878 PEC 880
Score = 37.0 bits (84), Expect = 0.16
Identities = 25/77 (32%), Positives = 31/77 (40%), Gaps = 9/77 (11%)
Query: 929 RPPTETPCNRHVPCPATWAVGNWSQCSVTCGE-GTQRRNVLCTNDTG-----VPCDEAQQ 982
R + P P W GNWS CS TCG G + + C G CD Q+
Sbjct: 1411 RTNSNDPTGEPPPQEPFWEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQK 1470
Query: 983 P-ASEVTCSLPLC--RW 996
P A C++ C RW
Sbjct: 1471 PLAGFEPCNIRDCPARW 1487
Score = 34.7 bits (78), Expect = 0.80
Identities = 21/63 (33%), Positives = 29/63 (46%), Gaps = 4/63 (6%)
Query: 546 AWSICSRSCGMGVQSAERQCTQP--TPKYKGRYCVGERKR-FRLCNLQACPAGRPSFRHV 602
+W CS +CG+G+Q+ + C P TP C E+ + CN CP G
Sbjct: 711 SWGPCSATCGVGIQTRDVYCLHPGETPA-PPEECRDEKPHALQACNQFDCPPGWHIEEWQ 769
Query: 603 QCS 605
QCS
Sbjct: 770 QCS 772
Score = 34.3 bits (77), Expect = 1.1
Identities = 13/26 (50%), Positives = 19/26 (73%)
Query: 1469 GNWSKCSRSCGGGSSVRDVQCVDTRD 1494
G+WS CSR+CGGG+S +C+ R+
Sbjct: 82 GDWSDCSRTCGGGASYSLRRCLTGRN 107
Score = 31.6 bits (70), Expect = 6.8
Identities = 16/43 (37%), Positives = 20/43 (46%), Gaps = 4/43 (9%)
Query: 1529 WRECSEACGGGEQQRLVTCPEPGLCE-EALRPNTTRPCNTHPC 1570
W +CS CGGG L C CE + +R T C+ H C
Sbjct: 84 WSDCSRTCGGGASYSLRRCLTGRNCEGQNIRYKT---CSNHDC 123
>gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens]
Length = 1762
Score = 230 bits (587), Expect = 8e-60
Identities = 152/486 (31%), Positives = 223/486 (45%), Gaps = 60/486 (12%)
Query: 538 DGGWSGWSAWSICSRSCGMGVQSAERQCTQPTPKYKGRYCVGERKRFRLCNLQACPAGRP 597
DG W W WS CSR+CG G + R+C + C G R+R C+ CP
Sbjct: 33 DGLWDAWGPWSECSRTCGGGASYSLRRCLS------SKSCEGRNIRYRTCSNVDCPPEAG 86
Query: 598 SFRHVQCSHFDAMLYKGQLHTWVPVVNDV-NPCELHCRPANEYFAEKLRDAVVDGTPCYQ 656
FR QCS + + + GQ + W+PV ND NPC L C+ +L V+DGT CY
Sbjct: 87 DFRAQQCSAHNDVKHHGQFYEWLPVSNDPDNPCSLKCQAKGTTLVVELAPKVLDGTRCYT 146
Query: 657 VRASRDLCINGICKNVGCDFEIDSGAMEDRCGVCHGNGSTCHTVSGTFEEAEGLGYVD-- 714
S D+CI+G+C+ VGCD ++ S ED CGVC+G+GSTC V G ++ D
Sbjct: 147 --ESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATKSDDT 204
Query: 715 VGLIPAGAREIRIQEVAEAANFLALRSEDPEKYFLNGGWTIQWNGDYQVAGTTFTYARRG 774
V IP G+R IR+ V + + L L ++ + G ++ G + V ++ + +
Sbjct: 205 VVAIPYGSRHIRL--VLKGPDHLYLETKTLQG--TKGENSLSSTGTFLVDNSSVDFQKFP 260
Query: 775 NWENLTSPGPTKEPVWIQLLFQESNPG----VHYEYTIHREAGGHDEVPPPVFSWHYGPW 830
+ E L GP +++ S + Y+ IHR W +
Sbjct: 261 DKEILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPIIHR--------------WRETDF 306
Query: 831 TKCTVTCGRGVQRQNVYCLE-RQAGPVDEEHCDPLG---RPDDQQRKCSEQPCPA----- 881
C+ TCG G Q + C + R V +++C +P + ++C+ PCPA
Sbjct: 307 FPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCPASDGYK 366
Query: 882 ------------RWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPR 929
RW A W CSSSCG GG+ RAV C+ +++E C + P+
Sbjct: 367 QIMPYDLYHPLPRWEATPWTACSSSCG-GGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPK 425
Query: 930 PPTETPCNRHVPCPATWAVGNWSQCSVTCGEGTQRRNVLCTNDTGV---PCDEAQQPASE 986
P PCN CP W WS C+VTCG+G + R VLC + G+ C +P +
Sbjct: 426 MPIAQPCN-IFDCP-KWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTKPHIK 483
Query: 987 VTCSLP 992
C +P
Sbjct: 484 EECIVP 489
Score = 119 bits (297), Expect = 3e-26
Identities = 89/286 (31%), Positives = 127/286 (44%), Gaps = 35/286 (12%)
Query: 1408 LVVRNAGWQAGNWSECSTTCGLGAVWRP-VRCSSGRDE----DCAPAGRP--QPARRCHL 1460
LV+++ W + CS +CG V +P +RC E CA RP QP C+
Sbjct: 1484 LVIQDYWWSVDRLATCSASCGNRGVQQPRLRCLLNSTEVNPAHCAGKVRPAVQPIA-CNR 1542
Query: 1461 RPCAT-WHSGNWSKCSRSCGGGSSVRDVQCVDTRDL---RPLRPFHCQPGPAKPPAHRPC 1516
R C + W +WS C+RSCGGG R V C + P+ C +P + C
Sbjct: 1543 RDCPSRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQAC 1602
Query: 1517 GAQPCLSWYTSSWRECSEACGGGE---QQRLVTCP-EPGL------CEEALRPNTTRPCN 1566
Q C+ W SSW +C+ C G Q R V C G+ C RP +T+ C
Sbjct: 1603 NQQLCVEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCW 1662
Query: 1567 THPCT-QWVVGPWGQCSGPCGG-GVQRRLVKCVNTQTG--LPEEDSDQCGHEAWPESSRP 1622
+ C+ W V W C+ CG G Q R V+CV+ +T +PE C P + +
Sbjct: 1663 SEACSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEH---LCSWGPRPANWQR 1719
Query: 1623 CGTEDCEPVEPPRCERDRLSFGFCETLRLLGRCQLPTIRTQCCRSC 1668
C CE +E R +CE ++ L CQL +++CC +C
Sbjct: 1720 CNITPCENMECRDTTR------YCEKVKQLKLCQLSQFKSRCCGTC 1759
Score = 117 bits (293), Expect = 9e-26
Identities = 62/151 (41%), Positives = 78/151 (51%), Gaps = 6/151 (3%)
Query: 822 VFSWHYGPWTKCTVTCGRGVQRQNVYCLERQA-GPVDEEHCDPLGRPDDQQRKCSEQPCP 880
++ W Y +TKC+ +CG GVQ V CL +Q P +E C RP + C+ PCP
Sbjct: 608 LYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPCP 667
Query: 881 ARWWAGEWQLCSSSCGPGGLSRRAVLC--IRSVGLDEQSALEPPACEHLPRPPTETPCNR 938
ARW G+W CS +CG GL R V C + S ++E L C P+P T CNR
Sbjct: 668 ARWEIGKWSPCSLTCGV-GLQTRDVFCSHLLSREMNETVILADELCRQ-PKPSTVQACNR 725
Query: 939 HVPCPATWAVGNWSQCSVTCGEGTQRRNVLC 969
CP W W CS TCG G Q+R VLC
Sbjct: 726 -FNCPPAWYPAQWQPCSRTCGGGVQKREVLC 755
Score = 107 bits (267), Expect = 1e-22
Identities = 76/241 (31%), Positives = 107/241 (44%), Gaps = 29/241 (12%)
Query: 1415 WQAGNWSECSTTCGLGAVWRPVRCSSGRDED------CAPAGRP-QPARRCHLRPC-ATW 1466
W+ +++CS +CG G V C + + + C + RP Q + C+L PC A W
Sbjct: 611 WEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPCPARW 670
Query: 1467 HSGNWSKCSRSCGGGSSVRDVQCVD--TRDLRP---LRPFHC-QPGPAKPPAHRPCGAQP 1520
G WS CS +CG G RDV C +R++ L C QP P+ A P
Sbjct: 671 EIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTVQACNRFNCPP 730
Query: 1521 CLSWYTSSWRECSEACGGGEQQRLVTCPE----------PGLCEEALRPNTTRPCNTHPC 1570
+WY + W+ CS CGGG Q+R V C + P A +P + C C
Sbjct: 731 --AWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSASKPACQQACKKDDC 788
Query: 1571 -TQWVVGPWGQCSGPCGGGVQRRLVKCVN-TQTGLPE-EDSDQCGHEAWPESSRPCGTED 1627
++W++ W +CS CG G Q R C +TGL +S C + S RPC
Sbjct: 789 PSEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLCPPLPFSSSIRPCMLAT 848
Query: 1628 C 1628
C
Sbjct: 849 C 849
Score = 101 bits (251), Expect = 7e-21
Identities = 56/186 (30%), Positives = 90/186 (48%), Gaps = 21/186 (11%)
Query: 825 WHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEH--CDPLGRPDDQQ--RKCSEQPCP 880
W G W+ C++TCG G+Q ++V+C + ++E D L R + C+ CP
Sbjct: 670 WEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTVQACNRFNCP 729
Query: 881 ARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPCNRHV 940
W+ +WQ CS +CG GG+ +R VLC + + L C +P + C +
Sbjct: 730 PAWYPAQWQPCSRTCG-GGVQKREVLCKQRMADGSFLELPETFCS-ASKPACQQACKKD- 786
Query: 941 PCPATWAVGNWSQCSVTCGEGTQRRNVLC-----------TNDT---GVPCDEAQQPASE 986
CP+ W + +W++CS +CGEGTQ R+ +C N T +P + +P
Sbjct: 787 DCPSEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLCPPLPFSSSIRPCML 846
Query: 987 VTCSLP 992
TC+ P
Sbjct: 847 ATCARP 852
Score = 99.8 bits (247), Expect = 2e-20
Identities = 74/259 (28%), Positives = 94/259 (36%), Gaps = 51/259 (19%)
Query: 1420 WSECSTTCGLGAVWRPVRCS-------SGRDEDCAPAGRPQPA--RRCHLRPCA------ 1464
WS C+ TCG+G R VRC S D P+PA R C+ PC+
Sbjct: 531 WSACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDECEGPKPASQRACYAGPCSGEIPEF 590
Query: 1465 -------------------TWHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQP 1505
W ++KCS SCGGG V C++ + P C
Sbjct: 591 NPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVT 650
Query: 1506 GPAKPPAHRPCGAQPC-LSWYTSSWRECSEACGGGEQQRLVTCPE-------------PG 1551
P + C PC W W CS CG G Q R V C
Sbjct: 651 SRRPPQLLKSCNLDPCPARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADE 710
Query: 1552 LCEEALRPNTTRPCNTHPC-TQWVVGPWGQCSGPCGGGVQRRLVKCVNTQT-GLPEEDSD 1609
LC + +P+T + CN C W W CS CGGGVQ+R V C G E +
Sbjct: 711 LCRQP-KPSTVQACNRFNCPPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPE 769
Query: 1610 QCGHEAWPESSRPCGTEDC 1628
+ P + C +DC
Sbjct: 770 TFCSASKPACQQACKKDDC 788
Score = 88.6 bits (218), Expect = 5e-17
Identities = 70/287 (24%), Positives = 106/287 (36%), Gaps = 73/287 (25%)
Query: 1415 WQAGNWSECSTTCGLGAVWRPVRC---------SSGRDEDCAPAGRPQPARRCHLRPCAT 1465
W+A W+ CS++CG G R V C +S + C + A+ C++ C
Sbjct: 380 WEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCPK 439
Query: 1466 WHSGNWSKCSRSCGGGSSVRDVQCVDTRDLR-----PLRPFHCQPGPAKP-PAHRPCGAQ 1519
W + WS C+ +CG G R V C+D R + P H + P P ++P
Sbjct: 440 WLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTKPHIKEECIVPTPCYKPKEKL 499
Query: 1520 PC---LSWY-------------------TSSWRECSEACGGGEQQRLVTCP-----EPGL 1552
P L W+ +W C+ CG G Q R+V C +
Sbjct: 500 PVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCGVGTQVRIVRCQVLLSFSQSV 559
Query: 1553 CE------EALRPNTTRPCNTHPCT-------------------------QWVVGPWGQC 1581
+ E +P + R C PC+ W + +C
Sbjct: 560 ADLPIDECEGPKPASQRACYAGPCSGEIPEFNPDETDGLFGGLQDFDELYDWEYEGFTKC 619
Query: 1582 SGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPCGTEDC 1628
S CGGGVQ +V C+N QT P E++ P+ + C + C
Sbjct: 620 SESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPC 666
Score = 86.3 bits (212), Expect = 2e-16
Identities = 58/187 (31%), Positives = 74/187 (39%), Gaps = 30/187 (16%)
Query: 1413 AGWQAGNWSECSTTCGLGAVWRPVRCSS-----------GRDEDCAPAGRPQPARRCHLR 1461
A W+ G WS CS TCG+G R V CS DE C +P + C+
Sbjct: 668 ARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQP-KPSTVQACNRF 726
Query: 1462 PC-ATWHSGNWSKCSRSCGGGSSVRDVQC---VDTRDLRPLRPFHCQPGPAKPPAHRPCG 1517
C W+ W CSR+CGGG R+V C + L C +KP + C
Sbjct: 727 NCPPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFC--SASKPACQQACK 784
Query: 1518 AQPCLS-WYTSSWRECSEACGGGEQQRLVTCPE-----------PGLCEEALRPNTTRPC 1565
C S W S W ECS +CG G Q R C + LC ++ RPC
Sbjct: 785 KDDCPSEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLCPPLPFSSSIRPC 844
Query: 1566 NTHPCTQ 1572
C +
Sbjct: 845 MLATCAR 851
Score = 85.9 bits (211), Expect = 3e-16
Identities = 46/165 (27%), Positives = 69/165 (41%), Gaps = 32/165 (19%)
Query: 1466 WHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQ--PGPAKP-PAHRPCGAQPCL 1522
W ++ CS +CGGG + +C D R R + +C P KP P + C PC
Sbjct: 301 WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCP 360
Query: 1523 S------------------WYTSSWRECSEACGGGEQQRLVTCPEPGL-----------C 1553
+ W + W CS +CGGG Q R V+C E + C
Sbjct: 361 ASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKC 420
Query: 1554 EEALRPNTTRPCNTHPCTQWVVGPWGQCSGPCGGGVQRRLVKCVN 1598
+ +PCN C +W+ W C+ CG G++ R+V C++
Sbjct: 421 MYTPKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCID 465
Score = 85.5 bits (210), Expect = 4e-16
Identities = 68/231 (29%), Positives = 93/231 (40%), Gaps = 30/231 (12%)
Query: 825 WHYGPWTKCTVTCG-RGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQPCPARW 883
W C+ +CG RGVQ+ + CL V+ HC RP Q C+ + CP+RW
Sbjct: 1491 WSVDRLATCSASCGNRGVQQPRLRCLLNST-EVNPAHCAGKVRPAVQPIACNRRDCPSRW 1549
Query: 884 WAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTET-PCNRHVPC 942
W C+ SCG GG+ R V C + + + C + + P +T CN+ + C
Sbjct: 1550 MVTSWSACTRSCG-GGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQL-C 1607
Query: 943 PATWAVGNWSQCSVTC---GEGTQRRNVLCTNDTGV-----PCDEAQQPASEVTCSLPLC 994
WA +W QC+ C Q R V C G+ C +P S C C
Sbjct: 1608 -VEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWSEAC 1666
Query: 995 R-------WPL--GTLGPEG--SGSGSSSHELFNEADFIPHHL---APRPS 1031
W L T G G S H N+A +P HL PRP+
Sbjct: 1667 SVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKA--VPEHLCSWGPRPA 1715
Score = 79.7 bits (195), Expect = 2e-14
Identities = 57/191 (29%), Positives = 74/191 (38%), Gaps = 43/191 (22%)
Query: 830 WTKCTVTCGRGVQRQNVYC-----LERQAGPVDEEHCDPLGRPDDQQRKCSEQPCPAR-- 882
W+ CTVTCG G Q + V C + + + C+ G QR C PC
Sbjct: 531 WSACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDECE--GPKPASQRACYAGPCSGEIP 588
Query: 883 ----------------------WWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALE 920
W + CS SCG GG+ V C+ + E
Sbjct: 589 EFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCG-GGVQEAVVSCLNK---QTREPAE 644
Query: 921 PPACEHLPRPPTETPCNRHVPCPATWAVGNWSQCSVTCGEGTQRRNVLCT-------NDT 973
C RPP PCPA W +G WS CS+TCG G Q R+V C+ N+T
Sbjct: 645 ENLCVTSRRPPQLLKSCNLDPCPARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNET 704
Query: 974 GVPCDE-AQQP 983
+ DE +QP
Sbjct: 705 VILADELCRQP 715
Score = 79.0 bits (193), Expect = 4e-14
Identities = 69/285 (24%), Positives = 100/285 (35%), Gaps = 73/285 (25%)
Query: 1415 WQAGNWSECSTTCGLGAVWRPVRCSSGR------DEDCA--PAG-RPQPA-RRCHLRPCA 1464
W+ ++ CS TCG G C R D+ C P +P+P + C+L PC
Sbjct: 301 WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCP 360
Query: 1465 T------------------WHSGNWSKCSRSCGGGSSVRDVQCVD---TRDLRPLRPFHC 1503
W + W+ CS SCGGG R V CV+ + + + C
Sbjct: 361 ASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKC 420
Query: 1504 QPGPAKPPAHRPCGAQPCLSWYTSSWRECSEACGGGEQQRLVTCPE-----PGLCEEALR 1558
P K P +PC C W W C+ CG G + R+V C + G C +
Sbjct: 421 MYTP-KMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTK 479
Query: 1559 PNTTRPCNT-HPC-------------------------------TQWVVGPWGQCSGPCG 1586
P+ C PC ++ W C+ CG
Sbjct: 480 PHIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCG 539
Query: 1587 GGVQRRLVKC---VNTQTGLPEEDSDQCGHEAWPESSRPCGTEDC 1628
G Q R+V+C ++ + + D+C P S R C C
Sbjct: 540 VGTQVRIVRCQVLLSFSQSVADLPIDEC-EGPKPASQRACYAGPC 583
Score = 69.7 bits (169), Expect = 2e-11
Identities = 39/121 (32%), Positives = 58/121 (47%), Gaps = 9/121 (7%)
Query: 820 PPVFSWHYGPWTKCTVTCGRGVQRQNVYCLERQAG----PVDEEHCDPLGRPDDQQRKCS 875
PP +W+ W C+ TCG GVQ++ V C +R A + E C +P QQ C
Sbjct: 729 PP--AWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCS-ASKPACQQ-ACK 784
Query: 876 EQPCPARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETP 935
+ CP+ W +W CS+SCG G +R A+ C + + + + C LP + P
Sbjct: 785 KDDCPSEWLLSDWTECSTSCGEGTQTRSAI-CRKMLKTGLSTVVNSTLCPPLPFSSSIRP 843
Query: 936 C 936
C
Sbjct: 844 C 844
Score = 41.2 bits (95), Expect = 0.009
Identities = 39/135 (28%), Positives = 53/135 (39%), Gaps = 35/135 (25%)
Query: 494 TLWCSVGTTCH------------SKLDAAVD---GTRCGENKWCLSGEC---VPVGFRPE 535
T+ C VGT S D +D G + + C +G C +P F P+
Sbjct: 535 TVTCGVGTQVRIVRCQVLLSFSQSVADLPIDECEGPKPASQRACYAGPCSGEIPE-FNPD 593
Query: 536 AVDGGWSG-----------WSAWSICSRSCGMGVQSAERQC--TQPTPKYKGRYCVGERK 582
DG + G + ++ CS SCG GVQ A C Q + CV R+
Sbjct: 594 ETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRR 653
Query: 583 RFRL---CNLQACPA 594
+L CNL CPA
Sbjct: 654 PPQLLKSCNLDPCPA 668
Score = 38.9 bits (89), Expect = 0.043
Identities = 22/57 (38%), Positives = 27/57 (47%), Gaps = 3/57 (5%)
Query: 825 WHYGPWTKCTVTCGR-GVQRQNVYCLERQAGPVDEEH-CDPLGRPDDQQRKCSEQPC 879
W WT CT TCG G Q + V C+ + EH C RP + QR C+ PC
Sbjct: 1670 WRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQR-CNITPC 1725
Score = 35.4 bits (80), Expect = 0.47
Identities = 22/62 (35%), Positives = 28/62 (45%), Gaps = 14/62 (22%)
Query: 1411 RNAGWQA-GNWSECSTTCGLGAVWRPVRCSSGR-------------DEDCAPAGRPQPAR 1456
R+ W A G WSECS TCG GA + RC S + + DC P A+
Sbjct: 32 RDGLWDAWGPWSECSRTCGGGASYSLRRCLSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQ 91
Query: 1457 RC 1458
+C
Sbjct: 92 QC 93
Score = 35.0 bits (79), Expect = 0.62
Identities = 19/55 (34%), Positives = 23/55 (41%), Gaps = 11/55 (20%)
Query: 1576 GPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPCGTEDCEP 1630
GPW +CS CGGG L +C++ S C E R C DC P
Sbjct: 40 GPWSECSRTCGGGASYSLRRCLS---------SKSC--EGRNIRYRTCSNVDCPP 83
Score = 33.9 bits (76), Expect = 1.4
Identities = 12/25 (48%), Positives = 19/25 (76%)
Query: 1469 GNWSKCSRSCGGGSSVRDVQCVDTR 1493
G WS+CSR+CGGG+S +C+ ++
Sbjct: 40 GPWSECSRTCGGGASYSLRRCLSSK 64
Score = 31.2 bits (69), Expect = 8.9
Identities = 20/57 (35%), Positives = 26/57 (45%), Gaps = 10/57 (17%)
Query: 545 SAWSICSRSCGMGVQSAERQCTQ------PTPKYKGRYCVGERKR---FRLCNLQAC 592
++WS C+RSCG GVQ+ C + TP C KR + CN Q C
Sbjct: 1552 TSWSACTRSCGGGVQTRRVTCQKLKASGISTP-VSNDMCTQVAKRPVDTQACNQQLC 1607
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.136 0.459
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 92,409,731
Number of Sequences: 37866
Number of extensions: 5987045
Number of successful extensions: 34471
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 161
Number of HSP's successfully gapped in prelim test: 1082
Number of HSP's that attempted gapping in prelim test: 22445
Number of HSP's gapped (non-prelim): 8473
length of query: 1686
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1570
effective length of database: 13,855,062
effective search space: 21752447340
effective search space used: 21752447340
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.