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Search of human proteins with 38570103
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|38570103 TBC1 domain family, member 8B (with GRAM domain)
isoform b [Homo sapiens]
(632 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|38570103 TBC1 domain family, member 8B (with GRAM domain) iso... 1283 0.0
gi|38570101 TBC1 domain family, member 8B (with GRAM domain) iso... 1245 0.0
gi|156231067 TBC1 domain family, member 8 [Homo sapiens] 711 0.0
gi|139394668 TBC1 domain family, member 9 (with GRAM domain) [Ho... 684 0.0
gi|45597177 TBC1 domain family, member 9B (with GRAM domain) iso... 674 0.0
gi|45597175 TBC1 domain family, member 9B (with GRAM domain) iso... 674 0.0
gi|29648315 small G protein signaling modulator 3 [Homo sapiens] 114 3e-25
gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens] 100 4e-21
gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens] 100 4e-21
gi|118722351 growth hormone regulated TBC protein 1 [Homo sapiens] 94 4e-19
gi|13994322 TBC1 domain family, member 10A [Homo sapiens] 92 2e-18
gi|38348348 TBC1 domain family, member 10C [Homo sapiens] 89 2e-17
gi|167614488 TBC1 domain family, member 10B [Homo sapiens] 86 1e-16
gi|7661864 USP6 N-terminal like isoform 1 [Homo sapiens] 82 2e-15
gi|122937432 USP6 N-terminal like isoform 2 [Homo sapiens] 82 2e-15
gi|222352143 TBC1 domain family, member 2 [Homo sapiens] 80 4e-15
gi|164519084 RAB GTPase activating protein 1 [Homo sapiens] 78 2e-14
gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo... 73 9e-13
gi|226693407 TBC1 domain family, member 3H [Homo sapiens] 71 3e-12
gi|109638751 ubiquitin specific protease 6 [Homo sapiens] 71 3e-12
gi|90577185 TBC1 domain family member 3C [Homo sapiens] 71 3e-12
gi|157502205 TBC1 domain family, member 3G [Homo sapiens] 71 3e-12
gi|14149985 TBC1 domain family, member 3F [Homo sapiens] 71 3e-12
gi|149999613 TBC1 domain family, member 3B [Homo sapiens] 71 3e-12
gi|68299759 ecotropic viral integration site 5 [Homo sapiens] 70 5e-12
gi|183583565 TBC1 domain family, member 3 [Homo sapiens] 70 5e-12
gi|183583567 TBC1 domain family, member 3E [Homo sapiens] 70 5e-12
gi|183583563 TBC1 domain family, member 3D [Homo sapiens] 70 5e-12
gi|229577000 ecotropic viral integration site 5-like isoform 1 [... 68 3e-11
gi|21687020 ecotropic viral integration site 5-like isoform 2 [H... 68 3e-11
>gi|38570103 TBC1 domain family, member 8B (with GRAM domain)
isoform b [Homo sapiens]
Length = 632
Score = 1283 bits (3321), Expect = 0.0
Identities = 632/632 (100%), Positives = 632/632 (100%)
Query: 1 MWLKPEEVLLKNALKLWLMERSNDYFVLQRRRGYGEEGGGGLTGLLVGTLDSVLDSTAKV 60
MWLKPEEVLLKNALKLWLMERSNDYFVLQRRRGYGEEGGGGLTGLLVGTLDSVLDSTAKV
Sbjct: 1 MWLKPEEVLLKNALKLWLMERSNDYFVLQRRRGYGEEGGGGLTGLLVGTLDSVLDSTAKV 60
Query: 61 APFRILHQTPDSQVYLSIACGANREEITKHWDWLEQNIMKTLSVFDSNEDITNFVQGKIR 120
APFRILHQTPDSQVYLSIACGANREEITKHWDWLEQNIMKTLSVFDSNEDITNFVQGKIR
Sbjct: 61 APFRILHQTPDSQVYLSIACGANREEITKHWDWLEQNIMKTLSVFDSNEDITNFVQGKIR 120
Query: 121 GLIAEEGKHCFAKEDDPEKFREALLKFEKCFGLPEKEKLVTYYSCSYWKGRVPCQGWLYL 180
GLIAEEGKHCFAKEDDPEKFREALLKFEKCFGLPEKEKLVTYYSCSYWKGRVPCQGWLYL
Sbjct: 121 GLIAEEGKHCFAKEDDPEKFREALLKFEKCFGLPEKEKLVTYYSCSYWKGRVPCQGWLYL 180
Query: 181 STNFLSFYSFLLGSEIKLIISWDEVSKLEKTSNVILTESIHVCSQGENHYFSMFLHINQT 240
STNFLSFYSFLLGSEIKLIISWDEVSKLEKTSNVILTESIHVCSQGENHYFSMFLHINQT
Sbjct: 181 STNFLSFYSFLLGSEIKLIISWDEVSKLEKTSNVILTESIHVCSQGENHYFSMFLHINQT 240
Query: 241 YLLMEQLANYAIRRLFDKETFDNDPVLYNPLQITKRGLENRAHSEQFNAFFRLPKGESLK 300
YLLMEQLANYAIRRLFDKETFDNDPVLYNPLQITKRGLENRAHSEQFNAFFRLPKGESLK
Sbjct: 241 YLLMEQLANYAIRRLFDKETFDNDPVLYNPLQITKRGLENRAHSEQFNAFFRLPKGESLK 300
Query: 301 EVHECFLWVPFSHFNTHGKMCISENYICFASQDGNQCSVIIPLREVLAIDKTNDSSKSVI 360
EVHECFLWVPFSHFNTHGKMCISENYICFASQDGNQCSVIIPLREVLAIDKTNDSSKSVI
Sbjct: 301 EVHECFLWVPFSHFNTHGKMCISENYICFASQDGNQCSVIIPLREVLAIDKTNDSSKSVI 360
Query: 361 ISIKGKTAFRFHEVKDFEQLVAKLRLRCGAASTQYHDISTELAISSESTEPSDNFEVQSL 420
ISIKGKTAFRFHEVKDFEQLVAKLRLRCGAASTQYHDISTELAISSESTEPSDNFEVQSL
Sbjct: 361 ISIKGKTAFRFHEVKDFEQLVAKLRLRCGAASTQYHDISTELAISSESTEPSDNFEVQSL 420
Query: 421 TSQRECSKTVNTEALMTVFHPQNLETLNSKMLKEKMKEQSWKILFAECGRGVSMFRTKKT 480
TSQRECSKTVNTEALMTVFHPQNLETLNSKMLKEKMKEQSWKILFAECGRGVSMFRTKKT
Sbjct: 421 TSQRECSKTVNTEALMTVFHPQNLETLNSKMLKEKMKEQSWKILFAECGRGVSMFRTKKT 480
Query: 481 RDLVVRGIPETLRGELWMLFSGAVNDMATNPDYYTEVVEQSLGTCNLATEEIERDLRRSL 540
RDLVVRGIPETLRGELWMLFSGAVNDMATNPDYYTEVVEQSLGTCNLATEEIERDLRRSL
Sbjct: 481 RDLVVRGIPETLRGELWMLFSGAVNDMATNPDYYTEVVEQSLGTCNLATEEIERDLRRSL 540
Query: 541 PEHPAFQSDTGISALRRVLTAYAYRNPKIGYCQAMNILTSVLLLYAKEEEAFWLLVAVCE 600
PEHPAFQSDTGISALRRVLTAYAYRNPKIGYCQAMNILTSVLLLYAKEEEAFWLLVAVCE
Sbjct: 541 PEHPAFQSDTGISALRRVLTAYAYRNPKIGYCQAMNILTSVLLLYAKEEEAFWLLVAVCE 600
Query: 601 RMLPDYFNRRIIGSDDFMPLVRIQGQCVIGEK 632
RMLPDYFNRRIIGSDDFMPLVRIQGQCVIGEK
Sbjct: 601 RMLPDYFNRRIIGSDDFMPLVRIQGQCVIGEK 632
>gi|38570101 TBC1 domain family, member 8B (with GRAM domain)
isoform a [Homo sapiens]
Length = 1120
Score = 1245 bits (3222), Expect = 0.0
Identities = 613/614 (99%), Positives = 614/614 (100%)
Query: 1 MWLKPEEVLLKNALKLWLMERSNDYFVLQRRRGYGEEGGGGLTGLLVGTLDSVLDSTAKV 60
MWLKPEEVLLKNALKLWLMERSNDYFVLQRRRGYGEEGGGGLTGLLVGTLDSVLDSTAKV
Sbjct: 1 MWLKPEEVLLKNALKLWLMERSNDYFVLQRRRGYGEEGGGGLTGLLVGTLDSVLDSTAKV 60
Query: 61 APFRILHQTPDSQVYLSIACGANREEITKHWDWLEQNIMKTLSVFDSNEDITNFVQGKIR 120
APFRILHQTPDSQVYLSIACGANREEITKHWDWLEQNIMKTLSVFDSNEDITNFVQGKIR
Sbjct: 61 APFRILHQTPDSQVYLSIACGANREEITKHWDWLEQNIMKTLSVFDSNEDITNFVQGKIR 120
Query: 121 GLIAEEGKHCFAKEDDPEKFREALLKFEKCFGLPEKEKLVTYYSCSYWKGRVPCQGWLYL 180
GLIAEEGKHCFAKEDDPEKFREALLKFEKCFGLPEKEKLVTYYSCSYWKGRVPCQGWLYL
Sbjct: 121 GLIAEEGKHCFAKEDDPEKFREALLKFEKCFGLPEKEKLVTYYSCSYWKGRVPCQGWLYL 180
Query: 181 STNFLSFYSFLLGSEIKLIISWDEVSKLEKTSNVILTESIHVCSQGENHYFSMFLHINQT 240
STNFLSFYSFLLGSEIKLIISWDEVSKLEKTSNVILTESIHVCSQGENHYFSMFLHINQT
Sbjct: 181 STNFLSFYSFLLGSEIKLIISWDEVSKLEKTSNVILTESIHVCSQGENHYFSMFLHINQT 240
Query: 241 YLLMEQLANYAIRRLFDKETFDNDPVLYNPLQITKRGLENRAHSEQFNAFFRLPKGESLK 300
YLLMEQLANYAIRRLFDKETFDNDPVLYNPLQITKRGLENRAHSEQFNAFFRLPKGESLK
Sbjct: 241 YLLMEQLANYAIRRLFDKETFDNDPVLYNPLQITKRGLENRAHSEQFNAFFRLPKGESLK 300
Query: 301 EVHECFLWVPFSHFNTHGKMCISENYICFASQDGNQCSVIIPLREVLAIDKTNDSSKSVI 360
EVHECFLWVPFSHFNTHGKMCISENYICFASQDGNQCSVIIPLREVLAIDKTNDSSKSVI
Sbjct: 301 EVHECFLWVPFSHFNTHGKMCISENYICFASQDGNQCSVIIPLREVLAIDKTNDSSKSVI 360
Query: 361 ISIKGKTAFRFHEVKDFEQLVAKLRLRCGAASTQYHDISTELAISSESTEPSDNFEVQSL 420
ISIKGKTAFRFHEVKDFEQLVAKLRLRCGAASTQYHDISTELAISSESTEPSDNFEVQSL
Sbjct: 361 ISIKGKTAFRFHEVKDFEQLVAKLRLRCGAASTQYHDISTELAISSESTEPSDNFEVQSL 420
Query: 421 TSQRECSKTVNTEALMTVFHPQNLETLNSKMLKEKMKEQSWKILFAECGRGVSMFRTKKT 480
TSQRECSKTVNTEALMTVFHPQNLETLNSKMLKEKMKEQSWKILFAECGRGVSMFRTKKT
Sbjct: 421 TSQRECSKTVNTEALMTVFHPQNLETLNSKMLKEKMKEQSWKILFAECGRGVSMFRTKKT 480
Query: 481 RDLVVRGIPETLRGELWMLFSGAVNDMATNPDYYTEVVEQSLGTCNLATEEIERDLRRSL 540
RDLVVRGIPETLRGELWMLFSGAVNDMATNPDYYTEVVEQSLGTCNLATEEIERDLRRSL
Sbjct: 481 RDLVVRGIPETLRGELWMLFSGAVNDMATNPDYYTEVVEQSLGTCNLATEEIERDLRRSL 540
Query: 541 PEHPAFQSDTGISALRRVLTAYAYRNPKIGYCQAMNILTSVLLLYAKEEEAFWLLVAVCE 600
PEHPAFQSDTGISALRRVLTAYAYRNPKIGYCQAMNILTSVLLLYAKEEEAFWLLVAVCE
Sbjct: 541 PEHPAFQSDTGISALRRVLTAYAYRNPKIGYCQAMNILTSVLLLYAKEEEAFWLLVAVCE 600
Query: 601 RMLPDYFNRRIIGS 614
RMLPDYFNRRIIG+
Sbjct: 601 RMLPDYFNRRIIGA 614
>gi|156231067 TBC1 domain family, member 8 [Homo sapiens]
Length = 1140
Score = 711 bits (1836), Expect = 0.0
Identities = 368/633 (58%), Positives = 464/633 (73%), Gaps = 20/633 (3%)
Query: 1 MWLKPEEVLLKNALKLWLMERSNDYFVLQRRRGYGEEGGGGLTGLLVGTLDSVLDSTAKV 60
MWLKPEEVLLKNALKLW+ ++S+ YF+LQRRRG+GE GGG LTG LVG LD+VLDS A+V
Sbjct: 1 MWLKPEEVLLKNALKLWVTQKSSCYFILQRRRGHGE-GGGRLTGRLVGALDAVLDSNARV 59
Query: 61 APFRILHQTPDSQVYLSIACGANREEITKHWDWLEQNIMKTLSVFDSNEDITNFVQGKIR 120
APFRIL Q P SQVY IACGA EEI +HWDWLEQN++ TLSVFD+ +DI +FV+GK++
Sbjct: 60 APFRILLQVPGSQVYSPIACGATLEEINQHWDWLEQNLLHTLSVFDNKDDIASFVKGKVK 119
Query: 121 GLIAEEGKHCFAK-EDDPEKFREALLKFEKCFGLPEKEKLVTYYSCSYWKGRVPCQGWLY 179
LIAEE A+ E++PEKFREAL+KFE F PE EKLVTYYSC WKGRVP QGWLY
Sbjct: 120 ALIAEETSSRLAEQEEEPEKFREALVKFEARFNFPEAEKLVTYYSCCCWKGRVPRQGWLY 179
Query: 180 LSTNFLSFYSFLLGSEIKLIISWDEVSKLEKTSNVILTESIHVCSQGENHYFSMFLHINQ 239
LS N L FYSF LG E+KL++ W ++ KLE+TSNV LT++I + +Q + FSMFL++++
Sbjct: 180 LSINHLCFYSFFLGKELKLVVPWVDIQKLERTSNVFLTDTIRITTQNKERDFSMFLNLDE 239
Query: 240 TYLLMEQLANYAIRRLFDKETFDNDPVLYNPLQITKRGLENRAHSEQFNAFFRLPKGESL 299
+ +MEQLA+ +RRL D E FD DP L P QITKR LE RA +E F AFFRLP+ E L
Sbjct: 240 VFKVMEQLADVTLRRLLDNEVFDLDPDLQEPSQITKRDLEARAQNEFFRAFFRLPRKEKL 299
Query: 300 KEVHECFLWVPFSHFNTHGKMCISENYICFASQDGNQCSVIIPLREVLAIDKTNDSS--- 356
V +C LW PFS +T G+M S++YICFAS++ C +I+PLREV++I+K D+S
Sbjct: 300 HAVVDCSLWTPFSRCHTTGRMFASDSYICFASREDGCCKIILPLREVVSIEKMEDTSLLP 359
Query: 357 KSVIISIKGKTAFRFHEVKDFEQLVAKL--RLRCGAASTQYH------DISTELAISSES 408
+I+SI+ K AF+F E++D + LV L RL+ A+ H D L S S
Sbjct: 360 HPIIVSIRSKVAFQFIELRDRDSLVEALLARLKQVHANHPVHYDTSADDDMASLVFHSTS 419
Query: 409 TEPSDNF-EVQSLTSQ------RECSKTVNTEALMTVFHPQNLETLNSKMLKEKMKEQSW 461
F +++ ++SQ +E S ++ +AL+T F ++ +S+M +E++K W
Sbjct: 420 MCSDHRFGDLEMMSSQNSEESEKEKSPLMHPDALVTAFQQSGSQSPDSRMSREQIKISLW 479
Query: 462 KILFAECGRGVSMFRTKKTRDLVVRGIPETLRGELWMLFSGAVNDMATNPDYYTEVVEQS 521
F E GR V MFRT+K R LV GIPE+LRG LW+LFS AV D+A++P YY +VE+S
Sbjct: 480 NDHFVEYGRTVCMFRTEKIRKLVAMGIPESLRGRLWLLFSDAVTDLASHPGYYGNLVEES 539
Query: 522 LGTCNLATEEIERDLRRSLPEHPAFQSDTGISALRRVLTAYAYRNPKIGYCQAMNILTSV 581
LG C L TEEIERDL RSLPEHPAFQ++TGI+ALRRVLTAYA+RNPKIGYCQ+MNILTSV
Sbjct: 540 LGKCCLVTEEIERDLHRSLPEHPAFQNETGIAALRRVLTAYAHRNPKIGYCQSMNILTSV 599
Query: 582 LLLYAKEEEAFWLLVAVCERMLPDYFNRRIIGS 614
LLLY KEEEAFWLLVAVCERMLPDYFN R+IG+
Sbjct: 600 LLLYTKEEEAFWLLVAVCERMLPDYFNHRVIGA 632
>gi|139394668 TBC1 domain family, member 9 (with GRAM domain) [Homo
sapiens]
Length = 1266
Score = 684 bits (1765), Expect = 0.0
Identities = 350/645 (54%), Positives = 470/645 (72%), Gaps = 34/645 (5%)
Query: 1 MWLKPEEVLLKNALKLWLMERSNDYFVLQRRRGYGEEGGGG--LTGLLVGTLDSVLDSTA 58
MW+ PEEVLL NAL W+ ER+N YF+LQRR+G+ +GGGG L GLLVGTLD VLDS+A
Sbjct: 1 MWVNPEEVLLANAL--WITERANPYFILQRRKGHAGDGGGGGGLAGLLVGTLDVVLDSSA 58
Query: 59 KVAPFRILHQTPDSQVYLSIACGANREEITKHWDWLEQNIMKTLSVFDSNEDITNFVQGK 118
+VAP+RIL+QTPDS VY +IACG +R+EIT+HW+WLEQN+++TLS+F++ DIT FV+GK
Sbjct: 59 RVAPYRILYQTPDSLVYWTIACGGSRKEITEHWEWLEQNLLQTLSIFENENDITTFVRGK 118
Query: 119 IRGLIAEEGKHCFAKEDDP-EKFREALLKFEKCFGLPEKEKLVTYYSCSYWKGRVPCQGW 177
I+G+IAE K KEDD EKF+EA++KF + FG+PE+EKLV YYSCSYWKG+VP QGW
Sbjct: 119 IQGIIAEYNKINDVKEDDDTEKFKEAIVKFHRLFGMPEEEKLVNYYSCSYWKGKVPRQGW 178
Query: 178 LYLSTNFLSFYSFLLGSEIKLIISWDEVSKLEKTSNVILTESIHVCSQGENHYFSMFLHI 237
+YLS N L FYSFL+G E KL+I W ++++LEK + ++L + I V ++ H+FS+FL+I
Sbjct: 179 MYLSINHLCFYSFLMGREAKLVIRWVDITQLEKNATLLLPDVIKVSTRSSEHFFSVFLNI 238
Query: 238 NQTYLLMEQLANYAIRRLFDKETFDNDPVL-----YNPLQIT--KRGLENRAHSEQFNAF 290
N+T+ LMEQLAN A+R+L D E F+ D L +P +++ KR L+ RA SE++ A
Sbjct: 239 NETFKLMEQLANIAMRQLLDNEGFEQDRSLPKLKRKSPKKVSALKRDLDARAKSERYRAL 298
Query: 291 FRLPKGESLKEVHECFLWVPFSHFNTHGKMCISENYICFASQDGNQCSVIIPLREVLAID 350
FRLPK E L +C LW PF+ + G+M +S NYICF S++ N CS+IIPLREV ++
Sbjct: 299 FRLPKDEKLDGHTDCTLWTPFNKMHILGQMFVSTNYICFTSKEENLCSLIIPLREVTIVE 358
Query: 351 KTNDSS---KSVIISIKGKTAFRFHEVKDFEQLVAKLRLRCGAASTQYHDISTELAISSE 407
K + SS + IS + + F F +KD + LV ++ +++ + E A S
Sbjct: 359 KADSSSVLPSPLSISTRNRMTFLFANLKDRDFLVQRISDFLQQTTSKIYS-DKEFAGSYN 417
Query: 408 STEPSDNFEVQSLTS---QRECSKTVN---------------TEALMTVFHPQNLETLNS 449
S++ SL S QR S + T+ LMT++ ++ E N
Sbjct: 418 SSDDEVYSRPSSLVSSSPQRSTSSDADGERQFNLNGNSVPTATQTLMTMYRRRSPEEFNP 477
Query: 450 KMLKEKMKEQSWKILFAECGRGVSMFRTKKTRDLVVRGIPETLRGELWMLFSGAVNDMAT 509
K+ KE +KEQ+WKI FAE G+G+ M+RT+KTR+LV++GIPE++RGELW+L SGA+N+ AT
Sbjct: 478 KLAKEFLKEQAWKIHFAEYGQGICMYRTEKTRELVLKGIPESMRGELWLLLSGAINEKAT 537
Query: 510 NPDYYTEVVEQSLGTCNLATEEIERDLRRSLPEHPAFQSDTGISALRRVLTAYAYRNPKI 569
+P YY ++VE+S+G NLATEEIERDL RSLPEHPAFQ++ GI+ALRRVLTAYA+RNP I
Sbjct: 538 HPGYYEDLVEKSMGKYNLATEEIERDLHRSLPEHPAFQNEMGIAALRRVLTAYAFRNPNI 597
Query: 570 GYCQAMNILTSVLLLYAKEEEAFWLLVAVCERMLPDYFNRRIIGS 614
GYCQAMNI+TSVLLLYAKEEEAFWLLVA+CERMLPDY+N R++G+
Sbjct: 598 GYCQAMNIVTSVLLLYAKEEEAFWLLVALCERMLPDYYNTRVVGA 642
>gi|45597177 TBC1 domain family, member 9B (with GRAM domain)
isoform b [Homo sapiens]
Length = 1233
Score = 674 bits (1740), Expect = 0.0
Identities = 353/639 (55%), Positives = 455/639 (71%), Gaps = 29/639 (4%)
Query: 1 MWLKPEEVLLKNALKLWLMERSNDYFVLQRRRGYGEEGGGGLTGLLVGTLDSVLDSTAKV 60
MWL PEEVL+ NAL W+ ER+N +FVLQRRRG+G GGGLTGLLVGTLD VLDS+A+V
Sbjct: 1 MWLSPEEVLVANAL--WVTERANPFFVLQRRRGHGR--GGGLTGLLVGTLDVVLDSSARV 56
Query: 61 APFRILHQTPDSQVYLSIACGANREEITKHWDWLEQNIMKTLSVFDSNEDITNFVQGKIR 120
AP+RILHQT DSQVY ++ACG++R+EITKHW+WLE N+++TLS+FDS EDIT FV+GKI
Sbjct: 57 APYRILHQTQDSQVYWTVACGSSRKEITKHWEWLENNLLQTLSIFDSEEDITTFVKGKIH 116
Query: 121 GLIAEEGKHCFAKED-DPEKFREALLKFEKCFGLPEKEKLVTYYSCSYWKGRVPCQGWLY 179
G+IAEE K+ + D DP KF+EA LK K FG+PE EKLV YYSCSYWKGRVP QGWLY
Sbjct: 117 GIIAEENKNLQPQGDEDPGKFKEAELKMRKQFGMPEGEKLVNYYSCSYWKGRVPRQGWLY 176
Query: 180 LSTNFLSFYSFLLGSEIKLIISWDEVSKLEKTSNVILTESIHVCSQGENHYFSMFLHINQ 239
L+ N L FYSFLLG E+ L++ W ++++LEK + ++ ESI V ++ + +FSMFL+I +
Sbjct: 177 LTVNHLCFYSFLLGKEVSLVVQWVDITRLEKNATLLFPESIRVDTRDQELFFSMFLNIGE 236
Query: 240 TYLLMEQLANYAIRRLFDKETFDNDPVLYNPLQ------ITKRGLENRAHSEQFNAFFRL 293
T+ LMEQLAN A+R+L D E F D L P++ KR L+ RA +E + A FRL
Sbjct: 237 TFKLMEQLANLAMRQLLDSEGFLEDKALPRPIRPHRNISALKRDLDARAKNECYRATFRL 296
Query: 294 PKGESLKEVHECFLWVPFSHFNTHGKMCISENYICFASQDGNQCSVIIPLREVLAIDKTN 353
P+ E L C LW PF+ + G+M IS NYICFAS++ + C +IIPLREV ++K +
Sbjct: 297 PRDERLDGHTSCTLWTPFNKLHIPGQMFISNNYICFASKEEDACHLIIPLREVTIVEKAD 356
Query: 354 DSS---KSVIISIKGKTAFRFHEVKDFEQLVAKLRL-----------RCGAASTQYHDIS 399
SS + IS K K F F +KD + LV ++ G+ D S
Sbjct: 357 SSSVLPSPLSISTKSKMTFLFANLKDRDFLVQRISDFLQKTPSKQPGSIGSRKASVVDPS 416
Query: 400 TELAISSESTEPSDNFEVQSLTSQRE-CSKTVNT--EALMTVFHPQN-LETLNSKMLKEK 455
TE + + + L+S++ C++ T + L+ +F + +E L +K KEK
Sbjct: 417 TESSPAPQEGSEQPASPASPLSSRQSFCAQEAPTASQGLLKLFQKNSPMEDLGAKGAKEK 476
Query: 456 MKEQSWKILFAECGRGVSMFRTKKTRDLVVRGIPETLRGELWMLFSGAVNDMATNPDYYT 515
MKE+SW I F E GRGV M+RT KTR LV++GIPE+LRGELW+LFSGA N+M T+P YY
Sbjct: 477 MKEESWHIHFFEYGRGVCMYRTAKTRALVLKGIPESLRGELWLLFSGAWNEMVTHPGYYA 536
Query: 516 EVVEQSLGTCNLATEEIERDLRRSLPEHPAFQSDTGISALRRVLTAYAYRNPKIGYCQAM 575
E+VE+S G +LATEEIERDL RS+PEHPAFQ++ GI+ALRRVLTAYA+RNP IGYCQAM
Sbjct: 537 ELVEKSTGKYSLATEEIERDLHRSMPEHPAFQNELGIAALRRVLTAYAFRNPTIGYCQAM 596
Query: 576 NILTSVLLLYAKEEEAFWLLVAVCERMLPDYFNRRIIGS 614
NI+TSVLLLY EEEAFWLLVA+CERMLPDY+N R++G+
Sbjct: 597 NIVTSVLLLYGSEEEAFWLLVALCERMLPDYYNTRVVGA 635
>gi|45597175 TBC1 domain family, member 9B (with GRAM domain)
isoform a [Homo sapiens]
Length = 1250
Score = 674 bits (1740), Expect = 0.0
Identities = 353/639 (55%), Positives = 455/639 (71%), Gaps = 29/639 (4%)
Query: 1 MWLKPEEVLLKNALKLWLMERSNDYFVLQRRRGYGEEGGGGLTGLLVGTLDSVLDSTAKV 60
MWL PEEVL+ NAL W+ ER+N +FVLQRRRG+G GGGLTGLLVGTLD VLDS+A+V
Sbjct: 1 MWLSPEEVLVANAL--WVTERANPFFVLQRRRGHGR--GGGLTGLLVGTLDVVLDSSARV 56
Query: 61 APFRILHQTPDSQVYLSIACGANREEITKHWDWLEQNIMKTLSVFDSNEDITNFVQGKIR 120
AP+RILHQT DSQVY ++ACG++R+EITKHW+WLE N+++TLS+FDS EDIT FV+GKI
Sbjct: 57 APYRILHQTQDSQVYWTVACGSSRKEITKHWEWLENNLLQTLSIFDSEEDITTFVKGKIH 116
Query: 121 GLIAEEGKHCFAKED-DPEKFREALLKFEKCFGLPEKEKLVTYYSCSYWKGRVPCQGWLY 179
G+IAEE K+ + D DP KF+EA LK K FG+PE EKLV YYSCSYWKGRVP QGWLY
Sbjct: 117 GIIAEENKNLQPQGDEDPGKFKEAELKMRKQFGMPEGEKLVNYYSCSYWKGRVPRQGWLY 176
Query: 180 LSTNFLSFYSFLLGSEIKLIISWDEVSKLEKTSNVILTESIHVCSQGENHYFSMFLHINQ 239
L+ N L FYSFLLG E+ L++ W ++++LEK + ++ ESI V ++ + +FSMFL+I +
Sbjct: 177 LTVNHLCFYSFLLGKEVSLVVQWVDITRLEKNATLLFPESIRVDTRDQELFFSMFLNIGE 236
Query: 240 TYLLMEQLANYAIRRLFDKETFDNDPVLYNPLQ------ITKRGLENRAHSEQFNAFFRL 293
T+ LMEQLAN A+R+L D E F D L P++ KR L+ RA +E + A FRL
Sbjct: 237 TFKLMEQLANLAMRQLLDSEGFLEDKALPRPIRPHRNISALKRDLDARAKNECYRATFRL 296
Query: 294 PKGESLKEVHECFLWVPFSHFNTHGKMCISENYICFASQDGNQCSVIIPLREVLAIDKTN 353
P+ E L C LW PF+ + G+M IS NYICFAS++ + C +IIPLREV ++K +
Sbjct: 297 PRDERLDGHTSCTLWTPFNKLHIPGQMFISNNYICFASKEEDACHLIIPLREVTIVEKAD 356
Query: 354 DSS---KSVIISIKGKTAFRFHEVKDFEQLVAKLRL-----------RCGAASTQYHDIS 399
SS + IS K K F F +KD + LV ++ G+ D S
Sbjct: 357 SSSVLPSPLSISTKSKMTFLFANLKDRDFLVQRISDFLQKTPSKQPGSIGSRKASVVDPS 416
Query: 400 TELAISSESTEPSDNFEVQSLTSQRE-CSKTVNT--EALMTVFHPQN-LETLNSKMLKEK 455
TE + + + L+S++ C++ T + L+ +F + +E L +K KEK
Sbjct: 417 TESSPAPQEGSEQPASPASPLSSRQSFCAQEAPTASQGLLKLFQKNSPMEDLGAKGAKEK 476
Query: 456 MKEQSWKILFAECGRGVSMFRTKKTRDLVVRGIPETLRGELWMLFSGAVNDMATNPDYYT 515
MKE+SW I F E GRGV M+RT KTR LV++GIPE+LRGELW+LFSGA N+M T+P YY
Sbjct: 477 MKEESWHIHFFEYGRGVCMYRTAKTRALVLKGIPESLRGELWLLFSGAWNEMVTHPGYYA 536
Query: 516 EVVEQSLGTCNLATEEIERDLRRSLPEHPAFQSDTGISALRRVLTAYAYRNPKIGYCQAM 575
E+VE+S G +LATEEIERDL RS+PEHPAFQ++ GI+ALRRVLTAYA+RNP IGYCQAM
Sbjct: 537 ELVEKSTGKYSLATEEIERDLHRSMPEHPAFQNELGIAALRRVLTAYAFRNPTIGYCQAM 596
Query: 576 NILTSVLLLYAKEEEAFWLLVAVCERMLPDYFNRRIIGS 614
NI+TSVLLLY EEEAFWLLVA+CERMLPDY+N R++G+
Sbjct: 597 NIVTSVLLLYGSEEEAFWLLVALCERMLPDYYNTRVVGA 635
>gi|29648315 small G protein signaling modulator 3 [Homo sapiens]
Length = 749
Score = 114 bits (285), Expect = 3e-25
Identities = 59/145 (40%), Positives = 92/145 (63%), Gaps = 3/145 (2%)
Query: 472 VSMFRTKKTRDLVVRGIPETLRGELWMLFSGAVNDMATNPDYYTEVVEQSLGTCNLATEE 531
VS+ R++K R LV+ GIP +R +LWM SGA+ + Y E+V+ S +A ++
Sbjct: 99 VSLPRSEKLRSLVLAGIPHGMRPQLWMRLSGALQKKRNSELSYREIVKNSSNDETIAAKQ 158
Query: 532 IERDLRRSLPEHPAFQS--DTGISALRRVLTAYAYRNPKIGYCQAMNILTSVLLLYAKEE 589
IE+DL R++P + F S G+ LRRVL A A+ P+IGYCQ ++ + LLL+ +EE
Sbjct: 159 IEKDLLRTMPSNACFASMGSIGVPRLRRVLRALAWLYPEIGYCQGTGMVAACLLLFLEEE 218
Query: 590 EAFWLLVAVCERMLP-DYFNRRIIG 613
+AFW++ A+ E +LP YF+ ++G
Sbjct: 219 DAFWMMSAIIEDLLPASYFSTTLLG 243
>gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens]
Length = 963
Score = 100 bits (249), Expect = 4e-21
Identities = 73/228 (32%), Positives = 116/228 (50%), Gaps = 16/228 (7%)
Query: 401 ELAISSESTE-PSDNFEVQSLTSQ------RECSKTVNTEALMTVFHPQNLETLNSKMLK 453
E A+ ES E P F L S+ R + E L+ +L+TL +
Sbjct: 570 EDALQVESQEQPEQAFVKPHLVSEYDIYGFRTVPEDDEEEKLVAKVRALDLKTLYLTENQ 629
Query: 454 EKMKEQSWKILFAECGRGVSMFRTKKTRDLVVRGIPETLRGELWML----FSGAVNDMAT 509
E W+ FA M + + ++L+ GIP R ++W + D T
Sbjct: 630 EVSTGVKWENYFASTVNR-EMMCSPELKNLIRAGIPHEHRSKVWKWCVDRHTRKFKDN-T 687
Query: 510 NPDYYTEVVEQSLGTCNLATEEIERDLRRSLPEHPAFQSDT--GISALRRVLTAYAYRNP 567
P ++ +++++L N A+++IE DL R+LP + + T GI LR VL A+++RNP
Sbjct: 688 EPGHFQTLLQKALEKQNPASKQIELDLLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNP 747
Query: 568 KIGYCQAMNILTSVLLLYAKEEEAFWLLVAVCERMLP-DYFNRRIIGS 614
IGYCQ +N L +V LLY ++E+AFW LV + E +P DY+ + ++GS
Sbjct: 748 DIGYCQGLNRLVAVALLYLEQEDAFWCLVTIVEVFMPRDYYTKTLLGS 795
>gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens]
Length = 914
Score = 100 bits (249), Expect = 4e-21
Identities = 73/228 (32%), Positives = 116/228 (50%), Gaps = 16/228 (7%)
Query: 401 ELAISSESTE-PSDNFEVQSLTSQ------RECSKTVNTEALMTVFHPQNLETLNSKMLK 453
E A+ ES E P F L S+ R + E L+ +L+TL +
Sbjct: 570 EDALQVESQEQPEQAFVKPHLVSEYDIYGFRTVPEDDEEEKLVAKVRALDLKTLYLTENQ 629
Query: 454 EKMKEQSWKILFAECGRGVSMFRTKKTRDLVVRGIPETLRGELWML----FSGAVNDMAT 509
E W+ FA M + + ++L+ GIP R ++W + D T
Sbjct: 630 EVSTGVKWENYFASTVNR-EMMCSPELKNLIRAGIPHEHRSKVWKWCVDRHTRKFKDN-T 687
Query: 510 NPDYYTEVVEQSLGTCNLATEEIERDLRRSLPEHPAFQSDT--GISALRRVLTAYAYRNP 567
P ++ +++++L N A+++IE DL R+LP + + T GI LR VL A+++RNP
Sbjct: 688 EPGHFQTLLQKALEKQNPASKQIELDLLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNP 747
Query: 568 KIGYCQAMNILTSVLLLYAKEEEAFWLLVAVCERMLP-DYFNRRIIGS 614
IGYCQ +N L +V LLY ++E+AFW LV + E +P DY+ + ++GS
Sbjct: 748 DIGYCQGLNRLVAVALLYLEQEDAFWCLVTIVEVFMPRDYYTKTLLGS 795
>gi|118722351 growth hormone regulated TBC protein 1 [Homo sapiens]
Length = 336
Score = 94.0 bits (232), Expect = 4e-19
Identities = 66/186 (35%), Positives = 93/186 (50%), Gaps = 19/186 (10%)
Query: 433 EALMTVFHPQNLETLNSKMLKEKMKEQSWKILFAECGRGVSMFRTKKTRDLVVRGIPETL 492
+A F L TL + +K W L G GV RT K V +G+P
Sbjct: 25 DAAYEKFFSSYLVTLTRRAIK-------WSRLLQ--GGGVPRSRTVKR--YVRKGVPLEH 73
Query: 493 RGELWMLFSGAVNDMATNPDYYTEVVEQSLGTCNLATEE-IERDLRRSLPEHPAFQSDTG 551
R +WM+ SGA M NP YY ++++ G N E+ I DL R+ P++ F+ T
Sbjct: 74 RARVWMVLSGAQAQMDQNPGYYHQLLQ---GERNPRLEDAIRTDLNRTFPDNVKFRKTTD 130
Query: 552 ISALR---RVLTAYAYRNPKIGYCQAMNILTSVLLLYA-KEEEAFWLLVAVCERMLPDYF 607
R VL AY + N +GYCQ MN + L+L EEE+FWLL A+ R+LPDY+
Sbjct: 131 PCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILITNNEEESFWLLDALVGRILPDYY 190
Query: 608 NRRIIG 613
+ ++G
Sbjct: 191 SPAMLG 196
>gi|13994322 TBC1 domain family, member 10A [Homo sapiens]
Length = 508
Score = 91.7 bits (226), Expect = 2e-18
Identities = 56/159 (35%), Positives = 82/159 (51%), Gaps = 5/159 (3%)
Query: 455 KMKEQSWKILFAECGRGVSMFRTKKTRDLVVRGIPETLRGELWMLFSGAVNDMATNPDYY 514
+ +E W + + ++ + KK R +GIP +LRG W SG + NP +
Sbjct: 80 RQRESKWLDMLNNWDKWMAK-KHKKIRLRCQKGIPPSLRGRAWQYLSGGKVKLQQNPGKF 138
Query: 515 TEVVEQSLGTCNLATEEIERDLRRSLPEHPAFQSDTGISA--LRRVLTAYAYRNPKIGYC 572
E+ + S G + IERDL R P H F S G L RVL AY P+ GYC
Sbjct: 139 DEL-DMSPGDPKWL-DVIERDLHRQFPFHEMFVSRGGHGQQDLFRVLKAYTLYRPEEGYC 196
Query: 573 QAMNILTSVLLLYAKEEEAFWLLVAVCERMLPDYFNRRI 611
QA + +VLL++ E+AFW LV +CE+ LP Y++ ++
Sbjct: 197 QAQAPIAAVLLMHMPAEQAFWCLVQICEKYLPGYYSEKL 235
>gi|38348348 TBC1 domain family, member 10C [Homo sapiens]
Length = 446
Score = 88.6 bits (218), Expect = 2e-17
Identities = 60/174 (34%), Positives = 84/174 (48%), Gaps = 9/174 (5%)
Query: 455 KMKEQSWKILFAECGRGVSMFRTKKTRDLVVRGIPETLRGELWMLFSGAVNDMATNPDYY 514
+ +E W + + + +S R KK + +GIP LR W L GA +P Y
Sbjct: 61 RQREMKWVEMTSHWEKTMSR-RYKKVKMQCRKGIPSALRARCWPLLCGAHVCQKNSPGTY 119
Query: 515 TEVVEQSLGTCNLATEEIERDLRRSLPEHPAFQSDTGIS--ALRRVLTAYAYRNPKIGYC 572
E+ E + T I RDL R P H F S G L +VL AY P+ GYC
Sbjct: 120 QELAEAPGDPQWMET--IGRDLHRQFPLHEMFVSPQGHGQQGLLQVLKAYTLYRPEQGYC 177
Query: 573 QAMNILTSVLLLYAKEEEAFWLLVAVCERMLPDYFNRRI----IGSDDFMPLVR 622
QA + +VLL++ EEAFW LV +CE LP Y+ + + ++ FM L+R
Sbjct: 178 QAQGPVAAVLLMHLPPEEAFWCLVQICEVYLPGYYGPHMEAVRLDAEVFMALLR 231
>gi|167614488 TBC1 domain family, member 10B [Homo sapiens]
Length = 808
Score = 85.5 bits (210), Expect = 1e-16
Identities = 51/156 (32%), Positives = 82/156 (52%), Gaps = 5/156 (3%)
Query: 455 KMKEQSWKILFAECGRGVSMFRTKKTRDLVVRGIPETLRGELWMLFSGAVNDMATNPDYY 514
+ +E W +F+ + +S R +K + +GIP +LR + W S + + NP +
Sbjct: 329 RQRELKWLDMFSNWDKWLSR-RFQKVKLRCRKGIPSSLRAKAWQYLSNSKELLEQNPGKF 387
Query: 515 TEVVEQSLGTCNLATEEIERDLRRSLPEHPAF--QSDTGISALRRVLTAYAYRNPKIGYC 572
E+ E++ G + IE+DL R P H F + G L R+L AY P GYC
Sbjct: 388 EEL-ERAPGDPKWL-DVIEKDLHRQFPFHEMFAARGGHGQQDLYRILKAYTIYRPDEGYC 445
Query: 573 QAMNILTSVLLLYAKEEEAFWLLVAVCERMLPDYFN 608
QA + +VLL++ E+AFW LV +C++ LP Y++
Sbjct: 446 QAQAPVAAVLLMHMPAEQAFWCLVQICDKYLPGYYS 481
>gi|7661864 USP6 N-terminal like isoform 1 [Homo sapiens]
Length = 828
Score = 81.6 bits (200), Expect = 2e-15
Identities = 49/160 (30%), Positives = 85/160 (53%), Gaps = 4/160 (2%)
Query: 440 HPQNLETLNSKMLKEKMKEQSWKILFAECGRGVSMFR-TKKTRDLVVRGIPETLRGELWM 498
H + L N + ++K E + + +G ++ T+K + +GIP LRGE+W
Sbjct: 52 HEEELPDHNVAVERQKHLEIERTTKWLKMLKGWEKYKNTEKFHRRIYKGIPLQLRGEVWA 111
Query: 499 LFSGAVNDMATNPDYYTEVVEQSLGTCNLATEEIERDLRRSLPEHPAFQSDTGIS--ALR 556
L D Y+++ ++ G C+ +I+ D+ R+ +H F+ G+ +L
Sbjct: 112 LLLEIPKMKEETRDLYSKLKHRARG-CSPDIRQIDLDVNRTFRDHIMFRDRYGVKQQSLF 170
Query: 557 RVLTAYAYRNPKIGYCQAMNILTSVLLLYAKEEEAFWLLV 596
VL AY+ N ++GYCQ M+ +T++LL+Y EE+AFW LV
Sbjct: 171 HVLAAYSIYNTEVGYCQGMSQITALLLMYMNEEDAFWALV 210
>gi|122937432 USP6 N-terminal like isoform 2 [Homo sapiens]
Length = 845
Score = 81.6 bits (200), Expect = 2e-15
Identities = 49/160 (30%), Positives = 85/160 (53%), Gaps = 4/160 (2%)
Query: 440 HPQNLETLNSKMLKEKMKEQSWKILFAECGRGVSMFR-TKKTRDLVVRGIPETLRGELWM 498
H + L N + ++K E + + +G ++ T+K + +GIP LRGE+W
Sbjct: 69 HEEELPDHNVAVERQKHLEIERTTKWLKMLKGWEKYKNTEKFHRRIYKGIPLQLRGEVWA 128
Query: 499 LFSGAVNDMATNPDYYTEVVEQSLGTCNLATEEIERDLRRSLPEHPAFQSDTGIS--ALR 556
L D Y+++ ++ G C+ +I+ D+ R+ +H F+ G+ +L
Sbjct: 129 LLLEIPKMKEETRDLYSKLKHRARG-CSPDIRQIDLDVNRTFRDHIMFRDRYGVKQQSLF 187
Query: 557 RVLTAYAYRNPKIGYCQAMNILTSVLLLYAKEEEAFWLLV 596
VL AY+ N ++GYCQ M+ +T++LL+Y EE+AFW LV
Sbjct: 188 HVLAAYSIYNTEVGYCQGMSQITALLLMYMNEEDAFWALV 227
>gi|222352143 TBC1 domain family, member 2 [Homo sapiens]
Length = 917
Score = 80.5 bits (197), Expect = 4e-15
Identities = 60/211 (28%), Positives = 100/211 (47%), Gaps = 11/211 (5%)
Query: 412 SDNFEVQSLTSQRECS----KTVNTEALMTVFHPQNLETLNSKMLKEKMKEQSWKILFAE 467
SD+ E+ ++ E E L + Q LE+ + +L + ++ + +A
Sbjct: 549 SDSIELSPISKYDEYGFLTVPDYEVEDLKLLAKIQALESRSHHLLGLEAVDRPLRERWAA 608
Query: 468 CGRGVSMFRTKKTRDLVVRGIPETLRGELWMLFSGAVNDMATNPDYYTEVVEQSLGTCNL 527
G + + + + L+ G+P R +W P Y E++ + +
Sbjct: 609 LG---DLVPSAELKQLLRAGVPREHRPRVWRWLVHLRVQHLHTPGCYQELLSRGQAREHP 665
Query: 528 ATEEIERDLRRSLPEHPAFQSDTGI--SALRRVLTAYAYRNPKIGYCQAMNILTSVLLLY 585
A +IE DL R+ P + F T LRRVL A++++NP IGYCQ +N L ++ LL
Sbjct: 666 AARQIELDLNRTFPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLV 725
Query: 586 AKEEE-AFWLLVAVCERMLP-DYFNRRIIGS 614
+EEE AFW LVA+ E ++P DY+ + S
Sbjct: 726 LEEEESAFWCLVAIVETIMPADYYCNTLTAS 756
>gi|164519084 RAB GTPase activating protein 1 [Homo sapiens]
Length = 1069
Score = 78.2 bits (191), Expect = 2e-14
Identities = 51/152 (33%), Positives = 81/152 (53%), Gaps = 9/152 (5%)
Query: 449 SKMLKEKMKEQSWKILFAECGRGVSMFRTKKTRDLVVRGIPETLRGELWMLFSGAVNDMA 508
SK EK+ E +W L ++ +++ R K+ LV G+PE LRGE+W L +G N+
Sbjct: 530 SKECAEKILE-TWGELLSKWHLNLNV-RPKQLSSLVRNGVPEALRGEVWQLLAGCHNNDH 587
Query: 509 TNPDYYTEVVEQSLGTCNLATEEIERDLRRSLPEHPAFQSD--TGISALRRVLTAYAYRN 566
Y + ++S I RD+ R+ P H F+ G +L ++ AY+ +
Sbjct: 588 LVEKYRILITKESP-----QDSAITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYD 642
Query: 567 PKIGYCQAMNILTSVLLLYAKEEEAFWLLVAV 598
+IGYCQ + L +VLLL+ EE+AF +LV +
Sbjct: 643 EEIGYCQGQSFLAAVLLLHMPEEQAFSVLVKI 674
>gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo
sapiens]
Length = 815
Score = 72.8 bits (177), Expect = 9e-13
Identities = 43/125 (34%), Positives = 64/125 (51%), Gaps = 7/125 (5%)
Query: 476 RTKKTRDLVVRGIPETLRGELWMLFSGAVNDMATNPDYYTEVVEQSLGTCNLATEEIERD 535
R K LV G+PE LR E+W L +G ++ A Y + + S I RD
Sbjct: 527 RPKGLSTLVKSGVPEALRAEVWQLLAGCHDNQAMLDRYRILITKDSA-----QESVITRD 581
Query: 536 LRRSLPEHPAFQSD--TGISALRRVLTAYAYRNPKIGYCQAMNILTSVLLLYAKEEEAFW 593
+ R+ P H F+ G +L ++ AY+ + IGYCQ + L +VLLL+ EE+AF
Sbjct: 582 IHRTFPAHDYFKDTGGDGQESLYKICKAYSVYDEDIGYCQGQSFLAAVLLLHMPEEQAFC 641
Query: 594 LLVAV 598
+LV +
Sbjct: 642 VLVKI 646
>gi|226693407 TBC1 domain family, member 3H [Homo sapiens]
Length = 549
Score = 71.2 bits (173), Expect = 3e-12
Identities = 44/162 (27%), Positives = 80/162 (49%), Gaps = 4/162 (2%)
Query: 438 VFHPQNLETLNSKMLKEKMKEQSWKILFAEC-GRGVSMFRTKKTRDLVVRGIPETLRGEL 496
+ H L L ++ K+ +E S K + + G ++K D +G+P +RG +
Sbjct: 51 IVHETELPPLTAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPM 110
Query: 497 WMLFSGAVNDMATNPDYYTEVVEQSLGTCNLATEEIERDLRRSLPEHPAFQSDTGISA-- 554
W + NP Y +++++ + + I+RD+ +L +H F+ G
Sbjct: 111 WSVLLNIEEMKLKNPGRY-QIMKEKGKRSSEHIQRIDRDISGTLRKHMFFRDRYGTKQRE 169
Query: 555 LRRVLTAYAYRNPKIGYCQAMNILTSVLLLYAKEEEAFWLLV 596
L +L AY NP++GYC+ ++ + ++ LLY EE+AFW LV
Sbjct: 170 LLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALV 211
>gi|109638751 ubiquitin specific protease 6 [Homo sapiens]
Length = 1406
Score = 71.2 bits (173), Expect = 3e-12
Identities = 45/162 (27%), Positives = 80/162 (49%), Gaps = 4/162 (2%)
Query: 438 VFHPQNLETLNSKMLKEKMKEQSWKILFAEC-GRGVSMFRTKKTRDLVVRGIPETLRGEL 496
+ H L + ++ K+ +E + + E G + + K D V +GIP +RG +
Sbjct: 50 ILHETELPPVTAREAKKIRREMTRTSKWMEMLGEWETYKHSSKLIDRVYKGIPMNIRGPV 109
Query: 497 WMLFSGAVNDMATNPDYYTEVVEQSLGTCNLATEEIERDLRRSLPEHPAFQSDTGISA-- 554
W + NP Y +++++ + I+ D+R +L H F+ G
Sbjct: 110 WSVLLNIQEIKLKNPGRY-QIMKERGKRSSEHIHHIDLDVRTTLRNHVFFRDRYGAKQRE 168
Query: 555 LRRVLTAYAYRNPKIGYCQAMNILTSVLLLYAKEEEAFWLLV 596
L +L AY+ NP++GYC+ ++ +T++ LLY EE+AFW LV
Sbjct: 169 LFYILLAYSEYNPEVGYCRDLSHITALFLLYLPEEDAFWALV 210
>gi|90577185 TBC1 domain family member 3C [Homo sapiens]
Length = 549
Score = 71.2 bits (173), Expect = 3e-12
Identities = 44/162 (27%), Positives = 80/162 (49%), Gaps = 4/162 (2%)
Query: 438 VFHPQNLETLNSKMLKEKMKEQSWKILFAEC-GRGVSMFRTKKTRDLVVRGIPETLRGEL 496
+ H L L ++ K+ +E S K + + G ++K D +G+P +RG +
Sbjct: 51 IVHETELPPLTAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPM 110
Query: 497 WMLFSGAVNDMATNPDYYTEVVEQSLGTCNLATEEIERDLRRSLPEHPAFQSDTGISA-- 554
W + NP Y +++++ + + I+RD+ +L +H F+ G
Sbjct: 111 WSVLLNIEEMKLKNPGRY-QIMKEKGKRSSEHIQRIDRDISGTLRKHMFFRDRYGTKQRE 169
Query: 555 LRRVLTAYAYRNPKIGYCQAMNILTSVLLLYAKEEEAFWLLV 596
L +L AY NP++GYC+ ++ + ++ LLY EE+AFW LV
Sbjct: 170 LLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALV 211
>gi|157502205 TBC1 domain family, member 3G [Homo sapiens]
Length = 549
Score = 71.2 bits (173), Expect = 3e-12
Identities = 44/162 (27%), Positives = 80/162 (49%), Gaps = 4/162 (2%)
Query: 438 VFHPQNLETLNSKMLKEKMKEQSWKILFAEC-GRGVSMFRTKKTRDLVVRGIPETLRGEL 496
+ H L L ++ K+ +E S K + + G ++K D +G+P +RG +
Sbjct: 51 IVHETELPPLTAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPM 110
Query: 497 WMLFSGAVNDMATNPDYYTEVVEQSLGTCNLATEEIERDLRRSLPEHPAFQSDTGISA-- 554
W + NP Y +++++ + + I+RD+ +L +H F+ G
Sbjct: 111 WSVLLNIEEMKLKNPGRY-QIMKEKGKRSSEHIQRIDRDISGTLRKHMFFRDRYGTKQRE 169
Query: 555 LRRVLTAYAYRNPKIGYCQAMNILTSVLLLYAKEEEAFWLLV 596
L +L AY NP++GYC+ ++ + ++ LLY EE+AFW LV
Sbjct: 170 LLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALV 211
>gi|14149985 TBC1 domain family, member 3F [Homo sapiens]
Length = 549
Score = 70.9 bits (172), Expect = 3e-12
Identities = 44/162 (27%), Positives = 80/162 (49%), Gaps = 4/162 (2%)
Query: 438 VFHPQNLETLNSKMLKEKMKEQSWKILFAEC-GRGVSMFRTKKTRDLVVRGIPETLRGEL 496
+ H L L ++ K+ +E S K + + G ++K D +G+P +RG +
Sbjct: 51 IVHETELPPLTAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPM 110
Query: 497 WMLFSGAVNDMATNPDYYTEVVEQSLGTCNLATEEIERDLRRSLPEHPAFQSDTGISA-- 554
W + NP Y +++++ + + I+RD+ +L +H F+ G
Sbjct: 111 WSVLLNTEEMKLKNPGRY-QIMKEKGKKSSEHIQRIDRDVSGTLRKHIFFRDRYGTKQRE 169
Query: 555 LRRVLTAYAYRNPKIGYCQAMNILTSVLLLYAKEEEAFWLLV 596
L +L AY NP++GYC+ ++ + ++ LLY EE+AFW LV
Sbjct: 170 LLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALV 211
>gi|149999613 TBC1 domain family, member 3B [Homo sapiens]
Length = 549
Score = 70.9 bits (172), Expect = 3e-12
Identities = 44/162 (27%), Positives = 80/162 (49%), Gaps = 4/162 (2%)
Query: 438 VFHPQNLETLNSKMLKEKMKEQSWKILFAEC-GRGVSMFRTKKTRDLVVRGIPETLRGEL 496
+ H L L ++ K+ +E S K + + G ++K D +G+P +RG +
Sbjct: 51 IVHETELPPLTAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPM 110
Query: 497 WMLFSGAVNDMATNPDYYTEVVEQSLGTCNLATEEIERDLRRSLPEHPAFQSDTGISA-- 554
W + NP Y +++++ + + I+RD+ +L +H F+ G
Sbjct: 111 WSVLLNIEEMKLKNPGRY-QIMKEKGKRSSEHIQRIDRDISGTLRKHMFFRDRYGTKQRE 169
Query: 555 LRRVLTAYAYRNPKIGYCQAMNILTSVLLLYAKEEEAFWLLV 596
L +L AY NP++GYC+ ++ + ++ LLY EE+AFW LV
Sbjct: 170 LLHILLAYEEYNPEVGYCRDLSHIAALFLLYFPEEDAFWALV 211
>gi|68299759 ecotropic viral integration site 5 [Homo sapiens]
Length = 810
Score = 70.5 bits (171), Expect = 5e-12
Identities = 75/309 (24%), Positives = 135/309 (43%), Gaps = 40/309 (12%)
Query: 342 PLREVLAIDKTNDSSKSVIISIKGKTAFRFHEVKDFEQLVAKLRLRCGAASTQYHDISTE 401
P + +A DK + S + +K + H V VA + ST H S+
Sbjct: 13 PSGKQVATDKVAEKLSSTLSWVKNTVS---HTVSQMASQVA-------SPSTSLHTTSSS 62
Query: 402 LAISSESTEPS-------DNFEVQSLTSQRECSKTVNTEALMTVFHPQN------LETLN 448
+S+ + PS D+ E+ + ++ ++++L +V + + + +
Sbjct: 63 TTLSTPALSPSSPSQLSPDDLELLAKLEEQNRLLETDSKSLRSVNGSRRNSGSSLVSSSS 122
Query: 449 SKMLKEKMKEQSWKILFAEC---GRGVSMFRTKKTRDLVVRGIPETLRGELWMLFSGAVN 505
+ ++E SW IL+ V + K+ ++LV +GIP R +W L A +
Sbjct: 123 ASSNLSHLEEDSW-ILWGRIVNEWEDVRKKKEKQVKELVHKGIPHHFRAIVWQLLCSAQS 181
Query: 506 DMATNPDYYTEVVEQSLGTCNLATEEIERDLRRSLPEHPAFQS--DTGISALRRVLTAYA 563
D Y+E+++ + L I RD+ R+ PEH F+ G L V+ AY+
Sbjct: 182 --MPIKDQYSELLKMTSPCEKL----IRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYS 235
Query: 564 YRNPKIGYCQAMNILTSVLLLYAKEEEAFWLLVAVCERMLPDYFNRRII-GSDDFMPLVR 622
+ ++GYCQ + +LL+ EEEAF + V +++ DY R + S + L
Sbjct: 236 LVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFV----KLMQDYRLRELFKPSMAELGLCM 291
Query: 623 IQGQCVIGE 631
Q +C+I E
Sbjct: 292 YQFECMIQE 300
>gi|183583565 TBC1 domain family, member 3 [Homo sapiens]
Length = 549
Score = 70.5 bits (171), Expect = 5e-12
Identities = 44/162 (27%), Positives = 80/162 (49%), Gaps = 4/162 (2%)
Query: 438 VFHPQNLETLNSKMLKEKMKEQSWKILFAEC-GRGVSMFRTKKTRDLVVRGIPETLRGEL 496
+ H L L ++ K+ +E S K + + G ++K D +G+P +RG +
Sbjct: 51 IVHETELPPLTAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPM 110
Query: 497 WMLFSGAVNDMATNPDYYTEVVEQSLGTCNLATEEIERDLRRSLPEHPAFQSDTGISA-- 554
W + NP Y +++++ + + I+RD+ +L +H F+ G
Sbjct: 111 WSVLLNIEEMKLKNPGRY-QIMKEKGKRSSEHIQRIDRDVSGTLRKHIFFRDRYGTKQRE 169
Query: 555 LRRVLTAYAYRNPKIGYCQAMNILTSVLLLYAKEEEAFWLLV 596
L +L AY NP++GYC+ ++ + ++ LLY EE+AFW LV
Sbjct: 170 LLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALV 211
>gi|183583567 TBC1 domain family, member 3E [Homo sapiens]
Length = 549
Score = 70.5 bits (171), Expect = 5e-12
Identities = 44/162 (27%), Positives = 80/162 (49%), Gaps = 4/162 (2%)
Query: 438 VFHPQNLETLNSKMLKEKMKEQSWKILFAEC-GRGVSMFRTKKTRDLVVRGIPETLRGEL 496
+ H L L ++ K+ +E S K + + G ++K D +G+P +RG +
Sbjct: 51 IVHETELPPLTAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPM 110
Query: 497 WMLFSGAVNDMATNPDYYTEVVEQSLGTCNLATEEIERDLRRSLPEHPAFQSDTGISA-- 554
W + NP Y +++++ + + I+RD+ +L +H F+ G
Sbjct: 111 WSVLLNIEEMKLKNPGRY-QIMKEKGKRSSEHIQRIDRDVSGTLRKHIFFRDRYGTKQRE 169
Query: 555 LRRVLTAYAYRNPKIGYCQAMNILTSVLLLYAKEEEAFWLLV 596
L +L AY NP++GYC+ ++ + ++ LLY EE+AFW LV
Sbjct: 170 LLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALV 211
>gi|183583563 TBC1 domain family, member 3D [Homo sapiens]
Length = 549
Score = 70.5 bits (171), Expect = 5e-12
Identities = 44/162 (27%), Positives = 80/162 (49%), Gaps = 4/162 (2%)
Query: 438 VFHPQNLETLNSKMLKEKMKEQSWKILFAEC-GRGVSMFRTKKTRDLVVRGIPETLRGEL 496
+ H L L ++ K+ +E S K + + G ++K D +G+P +RG +
Sbjct: 51 IVHETELPPLTAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPM 110
Query: 497 WMLFSGAVNDMATNPDYYTEVVEQSLGTCNLATEEIERDLRRSLPEHPAFQSDTGISA-- 554
W + NP Y +++++ + + I+RD+ +L +H F+ G
Sbjct: 111 WSVLLNIEEMKLKNPGRY-QIMKEKGKRSSEHIQRIDRDVSGTLRKHIFFRDRYGTKQRE 169
Query: 555 LRRVLTAYAYRNPKIGYCQAMNILTSVLLLYAKEEEAFWLLV 596
L +L AY NP++GYC+ ++ + ++ LLY EE+AFW LV
Sbjct: 170 LLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALV 211
>gi|229577000 ecotropic viral integration site 5-like isoform 1
[Homo sapiens]
Length = 805
Score = 67.8 bits (164), Expect = 3e-11
Identities = 52/178 (29%), Positives = 85/178 (47%), Gaps = 21/178 (11%)
Query: 456 MKEQSWKILFAECGRGVSMFRTKKTR---DLVVRGIPETLRGELWMLFSGAVNDMATNPD 512
++E +W IL+ +R +K + +L+ +GIP R +W L A + N
Sbjct: 82 LEEDTW-ILWGRIANEWEEWRRRKEKLLKELIRKGIPHHFRAIVWQLLCSATDMPVKNQ- 139
Query: 513 YYTEVVEQSLGTCNLATEEIERDLRRSLPEHPAF--QSDTGISALRRVLTAYAYRNPKIG 570
Y+E+++ S L I RD+ R+ PEH F Q G L V+ AY+ + ++G
Sbjct: 140 -YSELLKMSSPCEKL----IRRDIARTYPEHEFFKGQDSLGQEVLFNVMKAYSLVDREVG 194
Query: 571 YCQAMNILTSVLLLYAKEEEAFWLLVAVCERMLPDYFNRRIIGSDDFMPLVRIQGQCV 628
YCQ + +LL+ EEEAF + V R++ +Y R + F P + G C+
Sbjct: 195 YCQGSAFIVGLLLMQMPEEEAFCVFV----RLMQEYRLREL-----FKPSMAELGLCI 243
>gi|21687020 ecotropic viral integration site 5-like isoform 2 [Homo
sapiens]
Length = 794
Score = 67.8 bits (164), Expect = 3e-11
Identities = 52/178 (29%), Positives = 85/178 (47%), Gaps = 21/178 (11%)
Query: 456 MKEQSWKILFAECGRGVSMFRTKKTR---DLVVRGIPETLRGELWMLFSGAVNDMATNPD 512
++E +W IL+ +R +K + +L+ +GIP R +W L A + N
Sbjct: 82 LEEDTW-ILWGRIANEWEEWRRRKEKLLKELIRKGIPHHFRAIVWQLLCSATDMPVKNQ- 139
Query: 513 YYTEVVEQSLGTCNLATEEIERDLRRSLPEHPAF--QSDTGISALRRVLTAYAYRNPKIG 570
Y+E+++ S L I RD+ R+ PEH F Q G L V+ AY+ + ++G
Sbjct: 140 -YSELLKMSSPCEKL----IRRDIARTYPEHEFFKGQDSLGQEVLFNVMKAYSLVDREVG 194
Query: 571 YCQAMNILTSVLLLYAKEEEAFWLLVAVCERMLPDYFNRRIIGSDDFMPLVRIQGQCV 628
YCQ + +LL+ EEEAF + V R++ +Y R + F P + G C+
Sbjct: 195 YCQGSAFIVGLLLMQMPEEEAFCVFV----RLMQEYRLREL-----FKPSMAELGLCI 243
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.135 0.408
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,171,301
Number of Sequences: 37866
Number of extensions: 976942
Number of successful extensions: 2370
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 57
Number of HSP's successfully gapped in prelim test: 22
Number of HSP's that attempted gapping in prelim test: 2199
Number of HSP's gapped (non-prelim): 112
length of query: 632
length of database: 18,247,518
effective HSP length: 108
effective length of query: 524
effective length of database: 14,157,990
effective search space: 7418786760
effective search space used: 7418786760
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.