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Search of human proteins with 38488692
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|38488692 SH3 domain and tetratricopeptide repeats 2 [Homo
sapiens]
(1288 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|38488692 SH3 domain and tetratricopeptide repeats 2 [Homo sap... 2572 0.0
gi|145386551 SH3 domain and tetratricopeptide repeats 1 [Homo sa... 690 0.0
gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens] 65 5e-10
gi|224548927 G-protein signaling modulator 1 (AGS3-like, C. eleg... 50 2e-05
gi|224548925 G-protein signaling modulator 1 (AGS3-like, C. eleg... 50 2e-05
gi|164519122 LGN protein [Homo sapiens] 48 7e-05
gi|39930351 dynamin binding protein [Homo sapiens] 41 0.008
gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [H... 39 0.042
gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens] 38 0.071
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap... 37 0.16
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi... 37 0.16
gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens] 37 0.16
gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens] 37 0.16
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens] 37 0.16
gi|222446607 SH3 domain containing ring finger 2 [Homo sapiens] 36 0.27
gi|112789548 lymphocyte-specific protein tyrosine kinase precurs... 35 0.35
gi|112789546 lymphocyte-specific protein tyrosine kinase precurs... 35 0.35
gi|4505331 N-ethylmaleimide-sensitive factor attachment protein,... 35 0.35
gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens] 35 0.46
gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens] 35 0.61
gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens] 35 0.61
gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens] 35 0.61
gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 34 0.79
gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 34 0.79
gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo sapi... 34 0.79
gi|91105174 CD19 antigen [Homo sapiens] 34 1.0
gi|83415184 transmembrane and tetratricopeptide repeat containin... 34 1.0
gi|157671933 hypothetical protein LOC168090 [Homo sapiens] 34 1.0
gi|5174573 myeloid/lymphoid or mixed-lineage leukemia trithorax ... 33 1.3
gi|213385323 anaphase-promoting complex subunit 5 isoform b [Hom... 33 1.8
>gi|38488692 SH3 domain and tetratricopeptide repeats 2 [Homo sapiens]
Length = 1288
Score = 2572 bits (6666), Expect = 0.0
Identities = 1288/1288 (100%), Positives = 1288/1288 (100%)
Query: 1 MGGCFCIPRERSLTRGPGKETPSKDPTVSSECIASSEYKEKCFLPQNINPDLTLSFCVKS 60
MGGCFCIPRERSLTRGPGKETPSKDPTVSSECIASSEYKEKCFLPQNINPDLTLSFCVKS
Sbjct: 1 MGGCFCIPRERSLTRGPGKETPSKDPTVSSECIASSEYKEKCFLPQNINPDLTLSFCVKS 60
Query: 61 RSRRCVNGPLQEAARRRLWALENEDQEVRMLFKDLSARLVSIQSQRAQFLITFKTMEEIW 120
RSRRCVNGPLQEAARRRLWALENEDQEVRMLFKDLSARLVSIQSQRAQFLITFKTMEEIW
Sbjct: 61 RSRRCVNGPLQEAARRRLWALENEDQEVRMLFKDLSARLVSIQSQRAQFLITFKTMEEIW 120
Query: 121 KFSTYLNLGYVSMCLEHLLFDHKYWLNCILVEDTEIQVSVDDKHLETIYLGLLIQEGHFF 180
KFSTYLNLGYVSMCLEHLLFDHKYWLNCILVEDTEIQVSVDDKHLETIYLGLLIQEGHFF
Sbjct: 121 KFSTYLNLGYVSMCLEHLLFDHKYWLNCILVEDTEIQVSVDDKHLETIYLGLLIQEGHFF 180
Query: 181 CRALCSVTPPAEKEGECLTLCKNELISVKMAEAGSELEGVSLVTGQRGLVLVSALEPLPL 240
CRALCSVTPPAEKEGECLTLCKNELISVKMAEAGSELEGVSLVTGQRGLVLVSALEPLPL
Sbjct: 181 CRALCSVTPPAEKEGECLTLCKNELISVKMAEAGSELEGVSLVTGQRGLVLVSALEPLPL 240
Query: 241 PFHQWFLKNYPGSCGLSRKRDWTGSYQIGRGRCKALTGYEPGEKDELNFYQGESIEIIGF 300
PFHQWFLKNYPGSCGLSRKRDWTGSYQIGRGRCKALTGYEPGEKDELNFYQGESIEIIGF
Sbjct: 241 PFHQWFLKNYPGSCGLSRKRDWTGSYQIGRGRCKALTGYEPGEKDELNFYQGESIEIIGF 300
Query: 301 VIPGLQWFIGKSTSSGQVGFVPTRNIDPDSYSPMSRNSAFLSDEERCSLLALGSDKQTEC 360
VIPGLQWFIGKSTSSGQVGFVPTRNIDPDSYSPMSRNSAFLSDEERCSLLALGSDKQTEC
Sbjct: 301 VIPGLQWFIGKSTSSGQVGFVPTRNIDPDSYSPMSRNSAFLSDEERCSLLALGSDKQTEC 360
Query: 361 SSFLHTLARTDITSVYRLSGFESIQNPPNDLSASQPEGFKEVRPGRAWEEHQAVGSRQSS 420
SSFLHTLARTDITSVYRLSGFESIQNPPNDLSASQPEGFKEVRPGRAWEEHQAVGSRQSS
Sbjct: 361 SSFLHTLARTDITSVYRLSGFESIQNPPNDLSASQPEGFKEVRPGRAWEEHQAVGSRQSS 420
Query: 421 SSEDSSLEEELLSATSDSYRLPEPDDLDDPELLMDLSTGQEEEAENFAPILAFLDHEGYA 480
SSEDSSLEEELLSATSDSYRLPEPDDLDDPELLMDLSTGQEEEAENFAPILAFLDHEGYA
Sbjct: 421 SSEDSSLEEELLSATSDSYRLPEPDDLDDPELLMDLSTGQEEEAENFAPILAFLDHEGYA 480
Query: 481 DHFKSLYDFSFSFLTSSFYSFSEEDEFVAYLEASRKWAKKSHMTWAHARLCFLLGRLSIR 540
DHFKSLYDFSFSFLTSSFYSFSEEDEFVAYLEASRKWAKKSHMTWAHARLCFLLGRLSIR
Sbjct: 481 DHFKSLYDFSFSFLTSSFYSFSEEDEFVAYLEASRKWAKKSHMTWAHARLCFLLGRLSIR 540
Query: 541 KVKLSQARVYFEEAIHILNGAFEDLSLVATLYINLAAIYLKQRLRHKGSALLEKAGALLA 600
KVKLSQARVYFEEAIHILNGAFEDLSLVATLYINLAAIYLKQRLRHKGSALLEKAGALLA
Sbjct: 541 KVKLSQARVYFEEAIHILNGAFEDLSLVATLYINLAAIYLKQRLRHKGSALLEKAGALLA 600
Query: 601 CLPDRESSAKHELDVVAYVLRQGIVVGSSPLEARACFLAIRLLLSLGRHEEVLPFAERLQ 660
CLPDRESSAKHELDVVAYVLRQGIVVGSSPLEARACFLAIRLLLSLGRHEEVLPFAERLQ
Sbjct: 601 CLPDRESSAKHELDVVAYVLRQGIVVGSSPLEARACFLAIRLLLSLGRHEEVLPFAERLQ 660
Query: 661 LLSGHPPASEAVASVLSFLYDKKYLPHLAVASVQQHGIQSAQGMSLPIWQVHLVLQNTTK 720
LLSGHPPASEAVASVLSFLYDKKYLPHLAVASVQQHGIQSAQGMSLPIWQVHLVLQNTTK
Sbjct: 661 LLSGHPPASEAVASVLSFLYDKKYLPHLAVASVQQHGIQSAQGMSLPIWQVHLVLQNTTK 720
Query: 721 LLGFPSPGWGEVSALACPMLRQALAACEELADRSTQRALCLILSKVYLEHRSPDGAIHYL 780
LLGFPSPGWGEVSALACPMLRQALAACEELADRSTQRALCLILSKVYLEHRSPDGAIHYL
Sbjct: 721 LLGFPSPGWGEVSALACPMLRQALAACEELADRSTQRALCLILSKVYLEHRSPDGAIHYL 780
Query: 781 SQALVLGQLLGEQESFESSLCLAWAYLLASQAKKALDVLEPLLCSLKETESLTQRGVIYN 840
SQALVLGQLLGEQESFESSLCLAWAYLLASQAKKALDVLEPLLCSLKETESLTQRGVIYN
Sbjct: 781 SQALVLGQLLGEQESFESSLCLAWAYLLASQAKKALDVLEPLLCSLKETESLTQRGVIYN 840
Query: 841 LLGLALQGEGRVNRAAKSYLRALNRAQEVGDVHNQAVAMANLGHLSLKSWAQHPARNYLL 900
LLGLALQGEGRVNRAAKSYLRALNRAQEVGDVHNQAVAMANLGHLSLKSWAQHPARNYLL
Sbjct: 841 LLGLALQGEGRVNRAAKSYLRALNRAQEVGDVHNQAVAMANLGHLSLKSWAQHPARNYLL 900
Query: 901 QAVRLYCELQASKETDMELVQVFLWLAQVLVSGHQLTHGLLCYEMALLFGLRHRHLKSQL 960
QAVRLYCELQASKETDMELVQVFLWLAQVLVSGHQLTHGLLCYEMALLFGLRHRHLKSQL
Sbjct: 901 QAVRLYCELQASKETDMELVQVFLWLAQVLVSGHQLTHGLLCYEMALLFGLRHRHLKSQL 960
Query: 961 QATKSLCHFYSSVSPNPEACITYHEHWLALAQQLRDREMEGRLLESLGQLYRNLNTARSL 1020
QATKSLCHFYSSVSPNPEACITYHEHWLALAQQLRDREMEGRLLESLGQLYRNLNTARSL
Sbjct: 961 QATKSLCHFYSSVSPNPEACITYHEHWLALAQQLRDREMEGRLLESLGQLYRNLNTARSL 1020
Query: 1021 RRSLTCIKESLRIFIDLGETDKAAEAWLGAGRLHYLMQEDELVELCLQAAIQTALKSEEP 1080
RRSLTCIKESLRIFIDLGETDKAAEAWLGAGRLHYLMQEDELVELCLQAAIQTALKSEEP
Sbjct: 1021 RRSLTCIKESLRIFIDLGETDKAAEAWLGAGRLHYLMQEDELVELCLQAAIQTALKSEEP 1080
Query: 1081 LLALKLYEEAGDVFFNGTRHRHHAVEYYRAGAVPLARRLKAVRTELRIFNKLTELQISLE 1140
LLALKLYEEAGDVFFNGTRHRHHAVEYYRAGAVPLARRLKAVRTELRIFNKLTELQISLE
Sbjct: 1081 LLALKLYEEAGDVFFNGTRHRHHAVEYYRAGAVPLARRLKAVRTELRIFNKLTELQISLE 1140
Query: 1141 GYEKALEFATLAARLSTVTGDQRQELVAFHRLATVYYSLHMYEMAEDCYLKTLSLCPPWL 1200
GYEKALEFATLAARLSTVTGDQRQELVAFHRLATVYYSLHMYEMAEDCYLKTLSLCPPWL
Sbjct: 1141 GYEKALEFATLAARLSTVTGDQRQELVAFHRLATVYYSLHMYEMAEDCYLKTLSLCPPWL 1200
Query: 1201 QSPKEALYYAKVYYRLGRLTFCQLKDAHDATEYFLLALAAAVLLGDEELQDTIRSRLDNI 1260
QSPKEALYYAKVYYRLGRLTFCQLKDAHDATEYFLLALAAAVLLGDEELQDTIRSRLDNI
Sbjct: 1201 QSPKEALYYAKVYYRLGRLTFCQLKDAHDATEYFLLALAAAVLLGDEELQDTIRSRLDNI 1260
Query: 1261 CQSPLWHSRPSGCSSERARWLSGGGLAL 1288
CQSPLWHSRPSGCSSERARWLSGGGLAL
Sbjct: 1261 CQSPLWHSRPSGCSSERARWLSGGGLAL 1288
>gi|145386551 SH3 domain and tetratricopeptide repeats 1 [Homo
sapiens]
Length = 1336
Score = 690 bits (1780), Expect = 0.0
Identities = 469/1256 (37%), Positives = 679/1256 (54%), Gaps = 60/1256 (4%)
Query: 51 DLTLSFCVKSRSRRCVNGPLQEAARRRLWALENEDQEVRMLFKDLSARLVSIQSQRAQFL 110
DLTL R R + LQ+ R +L LEN+ +E+ + +LSARL+SI S + + +
Sbjct: 83 DLTLQLLAVRRKSRLRDPGLQQTLRGQLRLLENDSREMARVLGELSARLLSIHSDQDRIV 142
Query: 111 ITFKTMEEIWKFSTYLNLGYVSMCLEHLLFDHKYWLNCILVED-TEIQVSVDDKHLETIY 169
+TFKT EEIWKFSTY LG+ CL +LL D +WL E+ T IQV VD+ L +
Sbjct: 143 VTFKTFEEIWKFSTYHALGFTHHCLANLLMDQAFWLLLPSEEEETAIQVHVDENALRLTH 202
Query: 170 LGLLIQEGHFFCRALCS------VTPPAEKEGECLTLCKNELISVKMAEAGSELEGV--S 221
LLIQEG FF LC +T P + L + EA E + S
Sbjct: 203 ESLLIQEGPFF--VLCPDHHVRVMTGPRDAGNGPQAL--RQASGAPQGEAAPETDSSPPS 258
Query: 222 LVTGQRGLVLVSALEPLPLPFHQWFLKNYPGSCGLSRKRD-WTGSYQIGRGRCKALTGYE 280
+ + +A EPL +PFHQW L+ + G+ + G AL ++
Sbjct: 259 PSVSSEEVAVAAAPEPL-IPFHQWALRIPQDPIDDAMGGPVMPGNPLMAVGLASALADFQ 317
Query: 281 PGEKDELNFYQGESIEIIGFVIPGLQWFIGKSTSSGQVGFVPTRNIDPDSYSPMSRNSAF 340
+E+ F G+ IEI+G +P L W +G+ +SG+VGFV + I ++ F
Sbjct: 318 GSGPEEMTFRGGDLIEILGAQVPSLPWCVGRHAASGRVGFVRSSLISMQGPVSELESAIF 377
Query: 341 LSDEERCSLLALGSDKQTECSSFLHTLARTDITSVYRLSGFESIQN--------PPNDLS 392
L++EE+ S + G + + L ++ TD+ SVY L E + PP LS
Sbjct: 378 LNEEEK-SFFSEGCFSEEDARQLLRRMSGTDVCSVYSLDSVEEAETEQPQEKEIPPPCLS 436
Query: 393 ASQPEGFKEVRPGRAWEEHQAV-GSRQSSSSED---SSLEEELLSATSDSYRLPEPDDLD 448
E ++V+ E+ + G Q +S +S + L S+ L DD +
Sbjct: 437 PEPQETLQKVK--NVLEQCKTCPGCPQEPASWGLCAASSDVSLQDPEEPSFCLEAEDDWE 494
Query: 449 DPELLMDLSTGQEEEAENFAPILAFLDHEGYADHFKSLYDFSFSFLTSSFYSFSEEDEFV 508
DPE L L L FL+ GY F+ LYD + +L+S F SFS+E+E
Sbjct: 495 DPEALSSL--------------LLFLNAPGYKASFRGLYDVALPWLSSVFRSFSDEEELT 540
Query: 509 AYLEASRKWAKKSHMTWAHARLCFLLGRLSIRKVKLSQARVYFEEAIHILNGAFEDLSLV 568
L +R AKK+ + A ARLCFLLGRL R++KLSQARVYFEEA+ L G+F DL LV
Sbjct: 541 GRLAQARGAAKKAGLLMALARLCFLLGRLCSRRLKLSQARVYFEEALGALEGSFGDLFLV 600
Query: 569 ATLYINLAAIYLKQRLRHKGSALLEKAGALLACLPDRESSAKHELDVVAYVLRQGIVVGS 628
+Y NLA+IY KQ+ R K + ++ KA ALL PD S + E +++ LR+ + S
Sbjct: 601 VAVYANLASIYRKQKNREKCAQVVPKAMALLLGTPDHICSTEAEGELLQLALRRAVGGQS 660
Query: 629 SPLEARACFLAIRLLLSLGRHEEVLPFAERLQLLSGHPPASEAV-----ASVLSFLYDKK 683
EARACFL R + L + EE LPF ERL LL A EA +L+ +Y +K
Sbjct: 661 LQAEARACFLLARHHVHLKQPEEALPFLERLLLLHRDSGAPEAAWLSDCYLLLADIYSRK 720
Query: 684 YLPHLAVASVQQHGIQSAQGMSLPIWQVHLVLQNTTKLLGFPSPGWGEVSALACPMLRQA 743
LPHL ++ V+ +++ ++ + V+LVLQN + P A LRQA
Sbjct: 721 CLPHLVLSCVKVASLRTRGSLAGSLRSVNLVLQNAPQPHSLP--------AQTSHYLRQA 772
Query: 744 LAACEELADRSTQRALCLILSKVYLEHRSPDGAIHYLSQALVLGQLLGEQESFESSLCLA 803
LA+ ++ + L L+++Y H AI +++QA+ + G + + + LA
Sbjct: 773 LASLTPGTGQALRGPLYTSLAQLYSHHGCHGPAITFMTQAVEASAIAGVRAIVDHLVALA 832
Query: 804 WAYLLASQAKKALDVLEPLLCSLKETESLTQRGVIYNLLGLALQGEGRVNRAAKSYLRAL 863
W ++L Q+ ALD+L+ + ++ +E Q GVI N++ +AL+ GR +AA+SY RAL
Sbjct: 833 WLHVLHGQSPVALDILQSVRDAVVASED--QEGVIANMVAVALKRTGRTRQAAESYYRAL 890
Query: 864 NRAQEVGDVHNQAVAMANLGHLSLKSWAQHPARNYLLQAVRLYCELQASKETDMELVQVF 923
A+++G NQAV +AN G L L + A A++YLL+AVRL+ L E + V
Sbjct: 891 RVARDLGQQRNQAVGLANFGALCLHAGASRLAQHYLLEAVRLFSRLPLG-ECGRDFTHVL 949
Query: 924 LWLAQVLVSGHQLTHGLLCYEMALLFGLRHRHLKSQLQATKSLCHFYSSVSPNPEACITY 983
L L + G YE ALL + H++SQL+A + LCHFYS+V P+ C+ Y
Sbjct: 950 LQLGHLCTRQGPAQQGKGYYEWALLVAVEMGHVESQLRAVQRLCHFYSAVMPSEAQCVIY 1009
Query: 984 HEHWLALAQQLRDREMEGRLLESLGQLYRNLNTARSLRRSLTCIKESLRIFIDLGETDKA 1043
HE L+LA ++ D+ +EG+LLE++ QLY +L T R+ + +L K SL IFIDL + +K
Sbjct: 1010 HELQLSLACKVADKVLEGQLLETISQLYLSLGTERAYKSALDYTKRSLGIFIDLQKKEKE 1069
Query: 1044 AEAWLGAGRLHYLMQEDELVELCLQAAIQTALKSEEPLLALKLYEEAGDVFFNGTRHRHH 1103
A AWL AG+++Y++++ ELV+L +Q A AL + +P L L+L+E AGD+FF+G R
Sbjct: 1070 AHAWLQAGKIYYILRQSELVDLYIQVAQNVALYTGDPNLGLELFEAAGDIFFDGAWEREK 1129
Query: 1104 AVEYYRAGAVPLARRLKAVRTELRIFNKLTELQISLEGYEKALEFATLAARLSTVTGDQR 1163
AV +YR A+PLA + ELR+ NKL L +LE ++ LEFA +A LS GD+
Sbjct: 1130 AVSFYRDRALPLAVTTGNRKAELRLCNKLVALLATLEEPQEGLEFAHMALALSITLGDRL 1189
Query: 1164 QELVAFHRLATVYYSLHMYEMAEDCYLKTLSLCPPWLQSPKEALYYAKVYYRLGRLTFCQ 1223
E VA+HRLA + + L E+AE YLK LSLC L+ +E LYY KVY LG + F
Sbjct: 1190 NERVAYHRLAALQHRLGHGELAEHFYLKALSLCNSPLEFDEETLYYVKVYLVLGDIIFYD 1249
Query: 1224 LKDAHDATEYFLLALAAAVLLGDEELQDTIRSRLDNICQSPLWHSRPSGCSSERAR 1279
LKD DA Y+ LALAAAV LG+++ Q I +RL I + L S ++AR
Sbjct: 1250 LKDPFDAAGYYQLALAAAVDLGNKKAQLKIYTRLATIYHNFLLDREKSLFFYQKAR 1305
>gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens]
Length = 2481
Score = 64.7 bits (156), Expect = 5e-10
Identities = 109/493 (22%), Positives = 181/493 (36%), Gaps = 52/493 (10%)
Query: 736 ACPMLRQALAACEELADRSTQRALCLILSKVYLEHRSPDGAIHYLSQALVLGQLLGEQES 795
A P Q L +L D + +C L + + A+ Y Q L L + L ++ S
Sbjct: 613 AAPYYEQYLRLAPDLQDMEGEGKVCHNLGYAHYCLGNYQEAVKYYEQDLALAKDLHDKLS 672
Query: 796 FESSLC-LAWAYLLASQAKKALDVLEPLLCSLKETESLTQRGVIYNLLGLALQGEGRVNR 854
+ C L A+ KA + + LL + + + LG + +N
Sbjct: 673 QAKAYCNLGLAFKALLNFSKAEECQKYLLSLAQSLNNSQAKFRALGNLGDIFICKKDING 732
Query: 855 AAKSYLRALNRAQEVGDVHNQAVAMANLGHLSLKSWAQHPARNYLLQAVRLYCELQASKE 914
A K Y + L A +V D +A A A LG A Y Q + +Y EL
Sbjct: 733 AIKFYEQQLGLAHQVKDRRLEASAYAALGTAYRMIQKYDKALGYHTQELEVYQELSDLPG 792
Query: 915 TDMELVQVFLWLAQVLVSGHQLTHGLLCYEMALLFG--LRHRHLKSQLQATKSLCHFYSS 972
+ LA V ++ + T CYE L G L+ L++Q+ + +
Sbjct: 793 E----CRAHGHLAAVYMALGKYTMAFKCYEEQLDLGQKLKDPSLEAQVYGNMGITKMNMN 848
Query: 973 VSPNPEACITYHEHWLALAQQLRDREM---EGRLLESLGQLY--------------RNLN 1015
V E I Y E LA+ QQL E GR +LG Y + L+
Sbjct: 849 VM---EEAIGYFEQQLAMLQQLSGNESVLDRGRAYGNLGDCYEALGDYEEAIKYYEQYLS 905
Query: 1016 TARSLRR-----------------------SLTCIKESLRIFIDLGETDKAAEAWLGAGR 1052
A+SL R +L C ++ L + +LGE A+A+ G
Sbjct: 906 VAQSLNRMQDQAKAYRGLGNGHRAMGSLQQALVCFEKRLVVAHELGEAFNKAQAYGELGS 965
Query: 1053 LHYLMQEDELVELCLQAAIQTALKSEEPLLALKLYEEAGDVFFNGTRHRHHAVEYYRAGA 1112
LH + E CL+ + A ++ L G V+ + A++Y++
Sbjct: 966 LHSQLGNYEQAISCLERQLNIARDMKDRALESDAACGLGGVYQQMGEY-DTALQYHQLD- 1023
Query: 1113 VPLARRLKAVRTELRIFNKLTELQISLEGYEKALEFATLAARLSTVTGDQRQELVAFHRL 1172
+ +A + R + L SL +E+A+ + ++ D + V++ L
Sbjct: 1024 LQIAEETNNPTCQGRAYGNLGLTYESLGTFERAVVYQEQHLSIAAQMNDLAAKTVSYSSL 1083
Query: 1173 ATVYYSLHMYEMA 1185
+++L Y A
Sbjct: 1084 GRTHHALQNYSQA 1096
Score = 60.8 bits (146), Expect = 8e-09
Identities = 116/519 (22%), Positives = 193/519 (37%), Gaps = 96/519 (18%)
Query: 742 QALAACEELADRSTQRALCLILSKVYLEHRSPDGAIHYLSQALVLGQLLGEQESFESSLC 801
Q L E+L DR+ + L ++ D A+ L + Q L + + +
Sbjct: 459 QQLGIAEDLKDRAAEGRASSNLGIIHQMKGDYDTALKLHKTHLCIAQELSDYAAQGRAYG 518
Query: 802 -LAWAYLLASQAKKALDVLEPLLCSLKETESLTQRGVIYNLLGLALQGEGRVNRAAKSYL 860
+ AY +A+ L E + + L +A Q G +RA + Y
Sbjct: 519 NMGNAYNALGMYDQAVKYHRQELQISMEVNDRASQASTHGNLAVAYQALGAHDRALQHYQ 578
Query: 861 RALNRAQEVGDVHNQAVAMANLGHLSLKSWAQHPARNYLLQAVRLYCELQASKETDMELV 920
LN A+E+ D+ ++A A++NLG+ A Y Q +RL +LQ DME
Sbjct: 579 NHLNIARELRDIQSEARALSNLGNFHCSRGEYVQAAPYYEQYLRLAPDLQ-----DME-- 631
Query: 921 QVFLWLAQVLVSGHQLTHGLLCYEMALLFGLRHRHLKSQLQATKSLCHFYSSVSPNPEAC 980
G +C+ + G H L + +A K
Sbjct: 632 ----------------GEGKVCHNL----GYAHYCLGNYQEAVK---------------- 655
Query: 981 ITYHEHWLALAQQLRDREMEGRLLESLGQLYR---NLNTARSLRRSLTCIKESLR----- 1032
Y+E LALA+ L D+ + + +LG ++ N + A ++ L + +SL
Sbjct: 656 --YYEQDLALAKDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKYLLSLAQSLNNSQAK 713
Query: 1033 ---------IFI---DLGETDKAAEAWLGAGRLHYLMQEDELVELCLQAAIQTALKSEEP 1080
IFI D+ K E LG +D +E AA+ TA + +
Sbjct: 714 FRALGNLGDIFICKKDINGAIKFYEQQLGLAH----QVKDRRLEASAYAALGTAYRMIQK 769
Query: 1081 --------LLALKLYEEAGDVFFNGTRHRHHAVEYYRAG-----------AVPLARRLKA 1121
L++Y+E D+ H H A Y G + L ++LK
Sbjct: 770 YDKALGYHTQELEVYQELSDLPGECRAHGHLAAVYMALGKYTMAFKCYEEQLDLGQKLKD 829
Query: 1122 VRTELRIFNKLTELQISLEGYEKAL-EFATLAARLSTVTGDQR--QELVAFHRLATVYYS 1178
E +++ + ++++ E+A+ F A L ++G++ A+ L Y +
Sbjct: 830 PSLEAQVYGNMGITKMNMNVMEEAIGYFEQQLAMLQQLSGNESVLDRGRAYGNLGDCYEA 889
Query: 1179 LHMYEMAEDCYLKTLSLCPPWLQSPKEALYYAKVYYRLG 1217
L YE A Y + LS+ QS AK Y LG
Sbjct: 890 LGDYEEAIKYYEQYLSVA----QSLNRMQDQAKAYRGLG 924
Score = 60.5 bits (145), Expect = 1e-08
Identities = 122/590 (20%), Positives = 212/590 (35%), Gaps = 83/590 (14%)
Query: 741 RQALAACEELADRSTQRALCLILSKVYLEHRSPDGAIHYLSQALVLGQLLGEQESFESSL 800
R L +L DR + L VY A+ Q ++L + ++ S L
Sbjct: 298 RHQLVLAMKLKDREAASSALSSLGHVYTAIGDYPNALASHKQCVLLAKQSKDELSEAREL 357
Query: 801 C-LAWAYLLASQAKKALDVLEPLLCSLKETESLTQRGVIYNLLGLALQGEGRVNRAAKSY 859
+ Y+ + A+ E L K+ + + Y+ LG A ++A +
Sbjct: 358 GNMGAVYIAMGDFENAVQCHEQHLKIAKDLGNKREEARAYSNLGSAYHYRRNFDKAMSYH 417
Query: 860 LRALNRAQEVGDVHNQAVAMANLGHLSLKSWAQHPARNYLLQA----------------- 902
L AQE+ + + A A LGH + A+ Y Q
Sbjct: 418 NYVLELAQELMEKAIEMRAYAGLGHAARCMQDLERAKQYHEQQLGIAEDLKDRAAEGRAS 477
Query: 903 --VRLYCELQASKETDMELVQVFLWLAQVL----VSGH------QLTHGLLCYEMALLFG 950
+ + +++ +T ++L + L +AQ L G + L Y+ A+ +
Sbjct: 478 SNLGIIHQMKGDYDTALKLHKTHLCIAQELSDYAAQGRAYGNMGNAYNALGMYDQAVKYH 537
Query: 951 LRHRHLK-------SQLQATKSLCHFYSSVSPNPEACITYHEHWLALAQQLRDREMEGRL 1003
+ + SQ +L Y ++ + A Y H L +A++LRD + E R
Sbjct: 538 RQELQISMEVNDRASQASTHGNLAVAYQALGAHDRALQHYQNH-LNIARELRDIQSEARA 596
Query: 1004 LESLGQLY---------------------------------RNLNTAR----SLRRSLTC 1026
L +LG + NL A + + ++
Sbjct: 597 LSNLGNFHCSRGEYVQAAPYYEQYLRLAPDLQDMEGEGKVCHNLGYAHYCLGNYQEAVKY 656
Query: 1027 IKESLRIFIDLGETDKAAEAWLGAGRLHYLMQEDELVELCLQAAIQTALKSEEPLLALKL 1086
++ L + DL + A+A+ G + E C + + A +
Sbjct: 657 YEQDLALAKDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKYLLSLAQSLNNSQAKFRA 716
Query: 1087 YEEAGDVFFNGTRHRHHAVEYYRAGAVPLARRLKAVRTELRIFNKLTELQISLEGYEKAL 1146
GD+F + + A+++Y + LA ++K R E + L ++ Y+KAL
Sbjct: 717 LGNLGDIFI-CKKDINGAIKFYEQ-QLGLAHQVKDRRLEASAYAALGTAYRMIQKYDKAL 774
Query: 1147 EFATLAARLSTVTGDQRQELVAFHRLATVYYSLHMYEMAEDCYLKTLSLCPPWLQSPKEA 1206
+ T + D E A LA VY +L Y MA CY + L L Q K+
Sbjct: 775 GYHTQELEVYQELSDLPGECRAHGHLAAVYMALGKYTMAFKCYEEQLDLG----QKLKDP 830
Query: 1207 LYYAKVYYRLGRLTFCQLKDAHDATEYFLLALA-AAVLLGDEELQDTIRS 1255
A+VY +G +T + +A YF LA L G+E + D R+
Sbjct: 831 SLEAQVYGNMG-ITKMNMNVMEEAIGYFEQQLAMLQQLSGNESVLDRGRA 879
Score = 53.9 bits (128), Expect = 1e-06
Identities = 104/492 (21%), Positives = 178/492 (36%), Gaps = 89/492 (18%)
Query: 829 TESLTQRGVIYNLLGLALQGEGRVNRAAKSYLRALNRAQEVGDVHNQAVAMANLGHLSLK 888
T SL RG +++ L A G ++ + L+ A+ +GD + A NLG
Sbjct: 227 TCSLKLRGSVFSALSSAYWSLGNTEKSTGYMQQDLDVAKTLGDQTGECRAHGNLGSAFFS 286
Query: 889 SWAQHPA----RNYLLQAVRL-------------------------------YCELQASK 913
A R+ L+ A++L C L A +
Sbjct: 287 KGNYREALTNHRHQLVLAMKLKDREAASSALSSLGHVYTAIGDYPNALASHKQCVLLAKQ 346
Query: 914 ETD-MELVQVFLWLAQVLVSGHQLTHGLLCYEMALLFGLRHRHLKSQLQATKSLCHFYSS 972
D + + + V ++ + + C+E L + + + +A +L Y
Sbjct: 347 SKDELSEARELGNMGAVYIAMGDFENAVQCHEQHLKIAKDLGNKREEARAYSNLGSAY-H 405
Query: 973 VSPNPEACITYHEHWLALAQQLRDREMEGRLLESLGQLYRNLNTARSLRRSLTCIKESLR 1032
N + ++YH + L LAQ+L ++ +E R LG R + + L R+ ++ L
Sbjct: 406 YRRNFDKAMSYHNYVLELAQELMEKAIEMRAYAGLGHAARCM---QDLERAKQYHEQQLG 462
Query: 1033 IFIDLGETDKAAEAWLGAGRLHYLMQEDEL------VELCLQAAI--------------- 1071
I DL + A G +H + + + LC+ +
Sbjct: 463 IAEDLKDRAAEGRASSNLGIIHQMKGDYDTALKLHKTHLCIAQELSDYAAQGRAYGNMGN 522
Query: 1072 --------QTALKSEEPLLALKLYEEAGDVFFNGTRHRHHAVEYYRAGA----------- 1112
A+K L + + E D + H + AV Y GA
Sbjct: 523 AYNALGMYDQAVKYHRQELQISM--EVNDRASQASTHGNLAVAYQALGAHDRALQHYQNH 580
Query: 1113 VPLARRLKAVRTELRIFNKLTELQISLEGYEKALEFATLAARLSTVTGDQRQELVAFHRL 1172
+ +AR L+ +++E R + L S Y +A + RL+ D E H L
Sbjct: 581 LNIARELRDIQSEARALSNLGNFHCSRGEYVQAAPYYEQYLRLAPDLQDMEGEGKVCHNL 640
Query: 1173 ATVYYSLHMYEMAEDCYLKTLSLCPPWLQSPKEALYYAKVYYRLGRLTFCQLKDAHDATE 1232
+Y L Y+ A Y + L+L + + L AK Y LG L F L + A E
Sbjct: 641 GYAHYCLGNYQEAVKYYEQDLALA----KDLHDKLSQAKAYCNLG-LAFKALLNFSKAEE 695
Query: 1233 --YFLLALAAAV 1242
+LL+LA ++
Sbjct: 696 CQKYLLSLAQSL 707
Score = 52.4 bits (124), Expect = 3e-06
Identities = 105/475 (22%), Positives = 180/475 (37%), Gaps = 49/475 (10%)
Query: 742 QALAACEELADRSTQRALCLILSKVYLEHRSPDGAIHYLSQALVLGQLLGEQESFESSLC 801
Q L +EL+D + L+ VY+ A + L LGQ L + S E+ +
Sbjct: 779 QELEVYQELSDLPGECRAHGHLAAVYMALGKYTMAFKCYEEQLDLGQKL-KDPSLEAQVY 837
Query: 802 --LAWAYLLASQAKKALDVLEPLLCSLKE---TESLTQRGVIYNLLGLALQGEGRVNRAA 856
+ + + ++A+ E L L++ ES+ RG Y LG + G A
Sbjct: 838 GNMGITKMNMNVMEEAIGYFEQQLAMLQQLSGNESVLDRGRAYGNLGDCYEALGDYEEAI 897
Query: 857 KSYLRALNRAQEVGDVHNQAVAMANLGHLSLKSWAQHPARNYLLQAVRLYCE-LQASKET 915
K Y + L+ AQ + + +QA A LG+ H A L QA+ + + L + E
Sbjct: 898 KYYEQYLSVAQSLNRMQDQAKAYRGLGN-------GHRAMGSLQQALVCFEKRLVVAHEL 950
Query: 916 D--MELVQVFLWLAQVLVSGHQLTHGLLCYEMALLFGLRHRHLKSQLQATKSLCHFYSSV 973
Q + L + + C E L + + A L Y +
Sbjct: 951 GEAFNKAQAYGELGSLHSQLGNYEQAISCLERQLNIARDMKDRALESDAACGLGGVYQQM 1010
Query: 974 SPNPEACITYHEHWLALAQQLRDREMEGRLLESLGQLYRNLNTARSLRRSLTCIKESLRI 1033
A + YH+ L +A++ + +GR +LG Y +L T R++ ++ L I
Sbjct: 1011 GEYDTA-LQYHQLDLQIAEETNNPTCQGRAYGNLGLTYESLGT---FERAVVYQEQHLSI 1066
Query: 1034 FIDLGETDKAAEAWLGAGRLHYLMQEDELVELCLQAAIQTALKSEEPLLALKLYEEAGDV 1093
+ + ++ GR H+ +Q + LQ ++ A + K+ G
Sbjct: 1067 AAQMNDLAAKTVSYSSLGRTHHALQNYSQAVMYLQEGLRLAEQLGRREDEAKIRHGLGLS 1126
Query: 1094 FFNGTRHRHHAVEYYRAGAVPLARRLKA-VRTELRI---------FNKLTELQISLEGYE 1143
+ + YRA A+ R +A + T+ ++ + L + +SL ++
Sbjct: 1127 LWASGNLEEAQHQLYRASALFETIRHEAQLSTDYKLSLFDLQTSSYQALQRVLVSLGHHD 1186
Query: 1144 KALE---------FATLAARLST----------VTGDQRQELVAFHRLATVYYSL 1179
+AL FA L T VT DQ E+V R +YYSL
Sbjct: 1187 EALAVAERGRTRAFADLLVERQTGQQDSDPYSPVTIDQILEMVNGQRGLVLYYSL 1241
>gi|224548927 G-protein signaling modulator 1 (AGS3-like, C. elegans)
isoform a [Homo sapiens]
Length = 675
Score = 49.7 bits (117), Expect = 2e-05
Identities = 80/348 (22%), Positives = 136/348 (39%), Gaps = 43/348 (12%)
Query: 902 AVRLYCELQASKETDMELVQVFLWLAQVLVSGHQLTHGLLCYEMALLFGLRHRHLKSQLQ 961
A RLY ++AS +++ L ++ +G T G+ +E A+ G S +
Sbjct: 17 ARRLYSRMEAS------CLELALEGERLCKAGDFKT-GVAFFEAAVQVGTEDLKTLSAIY 69
Query: 962 ATKSLCHFYSSVSPNPEACITYHEHWLALAQQLRDREMEGRLLESLGQLYRNLNTARSLR 1021
+ +FY + YH+H L LA+ + DR E + +LG NT + L
Sbjct: 70 SQLGNAYFYLKEHGR---ALEYHKHDLLLARTIGDRMGEAKASGNLG------NTLKVLG 120
Query: 1022 R---SLTCIKESLRIFIDLGETDKAAEAWLGAGRLHYLMQEDELVELCLQAAIQTALKSE 1078
R + C + L I + G+ A A G +++ + +L AA T
Sbjct: 121 RFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAKGK----QLSWNAANAT----- 171
Query: 1079 EPLLALKLYEEAGDVFFNGTRHRHHAVEYYRAGAVPLARRLKAVRTELRIFNKLTELQIS 1138
++ G + + A E+Y + L + L + R + L
Sbjct: 172 ---------QDPGHLPPDVRETLCKASEFYERN-LSLVKELGDRAAQGRAYGNLGNTHYL 221
Query: 1139 LEGYEKALEFATLAARLSTVTGDQRQELVAFHRLATVYYSLHMYEMAEDCYLKTLSLCPP 1198
L + +A F ++ GD+ E A+ L + L +++A + Y KTL L
Sbjct: 222 LGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLS-- 279
Query: 1199 WLQSPKEALYYAKVYYRLGRLTFCQLKDAHDATEYFLLALAAAVLLGD 1246
+ ++ A+ Y LG T+ L+D A EY L L A L D
Sbjct: 280 --RQLRDQAVEAQACYSLGN-TYTLLQDYERAAEYHLRHLLIAQELAD 324
Score = 47.0 bits (110), Expect = 1e-04
Identities = 53/210 (25%), Positives = 92/210 (43%), Gaps = 20/210 (9%)
Query: 854 RAAKSYLRALNRAQEVGDVHNQAVAMANLG--HLSLKSWAQ----HPARNYLLQAVRLYC 907
+A++ Y R L+ +E+GD Q A NLG H L ++ + H R L + +
Sbjct: 187 KASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKER---LAIAKEFG 243
Query: 908 ELQASKETDMELVQVFLWLAQVLVSGHQLTHGLLCYEMALLFGLRHRHLKSQLQATKSLC 967
+ A + L ++L + V+ Y+ L + R + QA SL
Sbjct: 244 DKAAERRAYSNLGNAHVFLGRFDVAAEY-------YKKTLQLSRQLRDQAVEAQACYSLG 296
Query: 968 HFYSSVSPNPEACITYHEHWLALAQQLRDREMEGRLLESLGQLYRNLNTARSLRRSLTCI 1027
+ Y+ + + E YH L +AQ+L DR EGR SLG Y ++ ++LT
Sbjct: 297 NTYTLLQ-DYERAAEYHLRHLLIAQELADRVGEGRACWSLGNAYVSMGRP---AQALTFA 352
Query: 1028 KESLRIFIDLGETDKAAEAWLGAGRLHYLM 1057
K+ L+I ++G+ A + +L ++
Sbjct: 353 KKHLQISQEIGDRHGELTARMNVAQLQLVL 382
Score = 43.1 bits (100), Expect = 0.002
Identities = 84/364 (23%), Positives = 138/364 (37%), Gaps = 59/364 (16%)
Query: 550 YFEEAIHILNGAFEDLSLVATLYINL--AAIYLKQRLR----HKGSALLEKAGALLACLP 603
+FE A+ + EDL ++ +Y L A YLK+ R HK LL + +
Sbjct: 50 FFEAAVQV---GTEDLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLLART------IG 100
Query: 604 DRESSAKHE------------LDVVAYVLRQGIVV----GSSPLEARACFLAIRLLLSLG 647
DR AK D A ++ + + G EARA + + + G
Sbjct: 101 DRMGEAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAKG 160
Query: 648 RHEEVLPFAERLQLLSGH-PPASEAVASVLSFLYDKKYLPHLAVASVQQHGIQSAQGMSL 706
+ ++ A GH PP S Y++ ++ V++ G ++AQG +
Sbjct: 161 K--QLSWNAANATQDPGHLPPDVRETLCKASEFYERN------LSLVKELGDRAAQGRAY 212
Query: 707 P-IWQVHLVLQNTTKLLGFPSPGWGEVSALACPMLRQALAACEELADRSTQRALCLILSK 765
+ H +L N T+ F ++ LA +E D++ +R L
Sbjct: 213 GNLGNTHYLLGNFTEATTFH---------------KERLAIAKEFGDKAAERRAYSNLGN 257
Query: 766 VYLEHRSPDGAIHYLSQALVLGQLLGEQESFESSLC--LAWAYLLASQAKKALDVLEPLL 823
++ D A Y + L L + L +Q + E+ C L Y L ++A + L
Sbjct: 258 AHVFLGRFDVAAEYYKKTLQLSRQLRDQ-AVEAQACYSLGNTYTLLQDYERAAEYHLRHL 316
Query: 824 CSLKETESLTQRGVIYNLLGLALQGEGRVNRAAKSYLRALNRAQEVGDVHNQAVAMANLG 883
+E G LG A GR +A + L +QE+GD H + A N+
Sbjct: 317 LIAQELADRVGEGRACWSLGNAYVSMGRPAQALTFAKKHLQISQEIGDRHGELTARMNVA 376
Query: 884 HLSL 887
L L
Sbjct: 377 QLQL 380
>gi|224548925 G-protein signaling modulator 1 (AGS3-like, C. elegans)
isoform b [Homo sapiens]
Length = 457
Score = 49.7 bits (117), Expect = 2e-05
Identities = 80/348 (22%), Positives = 136/348 (39%), Gaps = 43/348 (12%)
Query: 902 AVRLYCELQASKETDMELVQVFLWLAQVLVSGHQLTHGLLCYEMALLFGLRHRHLKSQLQ 961
A RLY ++AS +++ L ++ +G T G+ +E A+ G S +
Sbjct: 17 ARRLYSRMEAS------CLELALEGERLCKAGDFKT-GVAFFEAAVQVGTEDLKTLSAIY 69
Query: 962 ATKSLCHFYSSVSPNPEACITYHEHWLALAQQLRDREMEGRLLESLGQLYRNLNTARSLR 1021
+ +FY + YH+H L LA+ + DR E + +LG NT + L
Sbjct: 70 SQLGNAYFYLKEHGR---ALEYHKHDLLLARTIGDRMGEAKASGNLG------NTLKVLG 120
Query: 1022 R---SLTCIKESLRIFIDLGETDKAAEAWLGAGRLHYLMQEDELVELCLQAAIQTALKSE 1078
R + C + L I + G+ A A G +++ + +L AA T
Sbjct: 121 RFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAKGK----QLSWNAANAT----- 171
Query: 1079 EPLLALKLYEEAGDVFFNGTRHRHHAVEYYRAGAVPLARRLKAVRTELRIFNKLTELQIS 1138
++ G + + A E+Y + L + L + R + L
Sbjct: 172 ---------QDPGHLPPDVRETLCKASEFYERN-LSLVKELGDRAAQGRAYGNLGNTHYL 221
Query: 1139 LEGYEKALEFATLAARLSTVTGDQRQELVAFHRLATVYYSLHMYEMAEDCYLKTLSLCPP 1198
L + +A F ++ GD+ E A+ L + L +++A + Y KTL L
Sbjct: 222 LGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLS-- 279
Query: 1199 WLQSPKEALYYAKVYYRLGRLTFCQLKDAHDATEYFLLALAAAVLLGD 1246
+ ++ A+ Y LG T+ L+D A EY L L A L D
Sbjct: 280 --RQLRDQAVEAQACYSLGN-TYTLLQDYERAAEYHLRHLLIAQELAD 324
Score = 47.0 bits (110), Expect = 1e-04
Identities = 53/210 (25%), Positives = 92/210 (43%), Gaps = 20/210 (9%)
Query: 854 RAAKSYLRALNRAQEVGDVHNQAVAMANLG--HLSLKSWAQ----HPARNYLLQAVRLYC 907
+A++ Y R L+ +E+GD Q A NLG H L ++ + H R L + +
Sbjct: 187 KASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKER---LAIAKEFG 243
Query: 908 ELQASKETDMELVQVFLWLAQVLVSGHQLTHGLLCYEMALLFGLRHRHLKSQLQATKSLC 967
+ A + L ++L + V+ Y+ L + R + QA SL
Sbjct: 244 DKAAERRAYSNLGNAHVFLGRFDVAAEY-------YKKTLQLSRQLRDQAVEAQACYSLG 296
Query: 968 HFYSSVSPNPEACITYHEHWLALAQQLRDREMEGRLLESLGQLYRNLNTARSLRRSLTCI 1027
+ Y+ + + E YH L +AQ+L DR EGR SLG Y ++ ++LT
Sbjct: 297 NTYTLLQ-DYERAAEYHLRHLLIAQELADRVGEGRACWSLGNAYVSMGRP---AQALTFA 352
Query: 1028 KESLRIFIDLGETDKAAEAWLGAGRLHYLM 1057
K+ L+I ++G+ A + +L ++
Sbjct: 353 KKHLQISQEIGDRHGELTARMNVAQLQLVL 382
Score = 43.1 bits (100), Expect = 0.002
Identities = 84/364 (23%), Positives = 138/364 (37%), Gaps = 59/364 (16%)
Query: 550 YFEEAIHILNGAFEDLSLVATLYINL--AAIYLKQRLR----HKGSALLEKAGALLACLP 603
+FE A+ + EDL ++ +Y L A YLK+ R HK LL + +
Sbjct: 50 FFEAAVQV---GTEDLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLLART------IG 100
Query: 604 DRESSAKHE------------LDVVAYVLRQGIVV----GSSPLEARACFLAIRLLLSLG 647
DR AK D A ++ + + G EARA + + + G
Sbjct: 101 DRMGEAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAKG 160
Query: 648 RHEEVLPFAERLQLLSGH-PPASEAVASVLSFLYDKKYLPHLAVASVQQHGIQSAQGMSL 706
+ ++ A GH PP S Y++ ++ V++ G ++AQG +
Sbjct: 161 K--QLSWNAANATQDPGHLPPDVRETLCKASEFYERN------LSLVKELGDRAAQGRAY 212
Query: 707 P-IWQVHLVLQNTTKLLGFPSPGWGEVSALACPMLRQALAACEELADRSTQRALCLILSK 765
+ H +L N T+ F ++ LA +E D++ +R L
Sbjct: 213 GNLGNTHYLLGNFTEATTFH---------------KERLAIAKEFGDKAAERRAYSNLGN 257
Query: 766 VYLEHRSPDGAIHYLSQALVLGQLLGEQESFESSLC--LAWAYLLASQAKKALDVLEPLL 823
++ D A Y + L L + L +Q + E+ C L Y L ++A + L
Sbjct: 258 AHVFLGRFDVAAEYYKKTLQLSRQLRDQ-AVEAQACYSLGNTYTLLQDYERAAEYHLRHL 316
Query: 824 CSLKETESLTQRGVIYNLLGLALQGEGRVNRAAKSYLRALNRAQEVGDVHNQAVAMANLG 883
+E G LG A GR +A + L +QE+GD H + A N+
Sbjct: 317 LIAQELADRVGEGRACWSLGNAYVSMGRPAQALTFAKKHLQISQEIGDRHGELTARMNVA 376
Query: 884 HLSL 887
L L
Sbjct: 377 QLQL 380
>gi|164519122 LGN protein [Homo sapiens]
Length = 684
Score = 47.8 bits (112), Expect = 7e-05
Identities = 72/341 (21%), Positives = 131/341 (38%), Gaps = 31/341 (9%)
Query: 939 GLLCYEMALLFGLRHRHLKSQLQATKSLCHFYSSVSPNPEACITYHEHWLALAQQLRDRE 998
G+ +E A+ G S + + +FY + + YH H L LA+ + D+
Sbjct: 43 GVSFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLH---DYAKALEYHHHDLTLARTIGDQL 99
Query: 999 MEGRLLESLGQLYRNLNTARSLRRSLTCIKESLRIFIDLGETDKAAEAWLGAGRLHYLMQ 1058
E + +LG + L + ++ C + L I +L + A A G +++
Sbjct: 100 GEAKASGNLGNTLKVLG---NFDEAIVCCQRHLDISRELNDKVGEARALYNLGNVYHAKG 156
Query: 1059 ED-------------ELVELCLQAAIQTALKSEEPLLALKLYEEAGDVFFNGTRHRHHAV 1105
+ E V LQAA+ ++ + AL G F N + H+ +
Sbjct: 157 KSFGCPGPQDVGEFPEEVRDALQAAVDFYEENLSLVTALGDRAAQGRAFGN-LGNTHYLL 215
Query: 1106 EYYRAGAVPLARRLKAVR------TELRIFNKLTELQISLEGYEKALEFATLAARLSTVT 1159
+R + +RL + E R ++ L I L +E A E+ L+
Sbjct: 216 GNFRDAVIAHEQRLLIAKEFGDKAAERRAYSNLGNAYIFLGEFETASEYYKKTLLLARQL 275
Query: 1160 GDQRQELVAFHRLATVYYSLHMYEMAEDCYLKTLSLCPPWLQSPKEALYYAKVYYRLGRL 1219
D+ E + + L Y L YE A D +LK L++ Q + + + + LG
Sbjct: 276 KDRAVEAQSCYSLGNTYTLLQDYEKAIDYHLKHLAIA----QELNDRIGEGRACWSLGN- 330
Query: 1220 TFCQLKDAHDATEYFLLALAAAVLLGDEELQDTIRSRLDNI 1260
+ L + A + L + +GD+ + T R L ++
Sbjct: 331 AYTALGNHDQAMHFAEKHLEISREVGDKSGELTARLNLSDL 371
Score = 41.2 bits (95), Expect = 0.006
Identities = 52/218 (23%), Positives = 85/218 (38%), Gaps = 24/218 (11%)
Query: 813 KKALDVLEPLLCSLKETESLTQRGVIYNLLGLALQGEG-------------RVNRAAKSY 859
++ LD+ L + E +L G +Y+ G + G + A Y
Sbjct: 126 QRHLDISRELNDKVGEARALYNLGNVYHAKGKSFGCPGPQDVGEFPEEVRDALQAAVDFY 185
Query: 860 LRALNRAQEVGDVHNQAVAMANLG--HLSLKSWAQHP-ARNYLLQAVRLYCELQASKETD 916
L+ +GD Q A NLG H L ++ A L + + + A +
Sbjct: 186 EENLSLVTALGDRAAQGRAFGNLGNTHYLLGNFRDAVIAHEQRLLIAKEFGDKAAERRAY 245
Query: 917 MELVQVFLWLAQVLVSGHQLTHGLLCYEMALLFGLRHRHLKSQLQATKSLCHFYSSVSPN 976
L +++L + + Y+ LL + + + Q+ SL + Y+ + +
Sbjct: 246 SNLGNAYIFLGEFETASEY-------YKKTLLLARQLKDRAVEAQSCYSLGNTYTLLQ-D 297
Query: 977 PEACITYHEHWLALAQQLRDREMEGRLLESLGQLYRNL 1014
E I YH LA+AQ+L DR EGR SLG Y L
Sbjct: 298 YEKAIDYHLKHLAIAQELNDRIGEGRACWSLGNAYTAL 335
>gi|39930351 dynamin binding protein [Homo sapiens]
Length = 1577
Score = 40.8 bits (94), Expect = 0.008
Identities = 53/184 (28%), Positives = 79/184 (42%), Gaps = 43/184 (23%)
Query: 187 VTPPAEKEGECLTLCKNELISVKMAEAGSELEGVSLVTGQRGLVLVSALEPLPLPFHQWF 246
VT P+ KEGE L +C E S EL+ + L G LV++ + P W
Sbjct: 59 VTIPSLKEGERLFVCICEFTS-------QELDNLPLHRGD--LVILDGI-----PTAGWL 104
Query: 247 LKN--------YPGSCGL-----SRKRDW---TGSYQI---GRGRCKALTGYEPGEKDEL 287
+P SC S+ R W + +QI G+ +AL G +EL
Sbjct: 105 QGRSCWGARGFFPSSCVRELCLSSQSRQWHSQSALFQIPEYSMGQARALMGLSAQLDEEL 164
Query: 288 NFYQGESIEIIGFVIPGLQWFIGKSTSSGQV---GFV----PTRNIDPDSYSPMSRNSAF 340
+F +G+ I IIG PG WF G+ + GFV P R +D +S S +++
Sbjct: 165 DFREGDVITIIGVPEPG--WFEGELEGRRGIFPEGFVELLGPLRTVD-ESVSSGNQDDCI 221
Query: 341 LSDE 344
++ E
Sbjct: 222 VNGE 225
>gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [Homo
sapiens]
Length = 756
Score = 38.5 bits (88), Expect = 0.042
Identities = 40/169 (23%), Positives = 72/169 (42%), Gaps = 19/169 (11%)
Query: 257 SRKRDWTGSYQIGRGRCKALTGYEPGEKDELNFYQGESIEIIGFVIPGLQWFIGKSTSSG 316
+R+R + + CK Y P + DEL GE +E+I + G W++GK +G
Sbjct: 72 ARRRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDG--WWLGK--KNG 127
Query: 317 QVGFVPTRNID-----PDSYSPMSRNSAFLSDEERCSLLALGSDKQTECSSFLHTLARTD 371
Q+G P+ ++ P S S + L +L D + +L T++ +
Sbjct: 128 QLGAFPSNFVELLDSGPPSLGNPDMPSVSPGPQRPPKLSSLAYDSPPD---YLQTVSHPE 184
Query: 372 ITSVYRLSGFESIQNPPNDLSASQPEGFK---EVRPGRAWEEHQAVGSR 417
VYR+ F+ P++L+ + + K + + W E + G R
Sbjct: 185 ---VYRVL-FDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRR 229
>gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens]
Length = 2390
Score = 37.7 bits (86), Expect = 0.071
Identities = 58/232 (25%), Positives = 92/232 (39%), Gaps = 44/232 (18%)
Query: 865 RAQEVGDVHNQAVAMAN----LGHLSLKSWAQHPARNYLLQAVRLYCE-LQASKETDM-- 917
R +EV + QA A+A G + S A L Q +R C LQAS+E
Sbjct: 1435 REKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQASREQHQFH 1494
Query: 918 -ELVQVFLWLAQVLVSGHQLTHGLLCYEMALLFGLRHRHLKSQLQATKSLCHFYSSVSPN 976
++ LW+ + L + HG + LL +++ L+ ++Q
Sbjct: 1495 RDVEDEILWVTERLPMASSMEHGKDLPSVQLLMK-KNQTLQKEIQG-------------- 1539
Query: 977 PEACITYHEHWLALAQQLRDREME------GRLLESLGQLYRNLNTARSLR-RSLTCIKE 1029
HE +A LR+R+ G L L ++++ L LR + L
Sbjct: 1540 -------HEPRIA---DLRERQRALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALR 1589
Query: 1030 SLRIFIDLGETDKAAEAWLGAGRLHYLMQEDELVELCLQAAIQTALKSEEPL 1081
+ + + D E AEAW+G LH + QE EL QA ++ E+ L
Sbjct: 1590 AQQFYRDAAE----AEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQAL 1637
>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 36.6 bits (83), Expect = 0.16
Identities = 17/54 (31%), Positives = 31/54 (57%), Gaps = 2/54 (3%)
Query: 275 ALTGYEPGEKDELNFYQGESIEIIGFVIPGLQWFIGKSTSSGQVGFVPTRNIDP 328
AL YE + +L+F +GE ++I+ W++ S S+GQ G++P+ + P
Sbjct: 91 ALYDYESRTETDLSFKKGERLQIVNNTEG--DWWLAHSLSTGQTGYIPSNYVAP 142
>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 36.6 bits (83), Expect = 0.16
Identities = 17/54 (31%), Positives = 31/54 (57%), Gaps = 2/54 (3%)
Query: 275 ALTGYEPGEKDELNFYQGESIEIIGFVIPGLQWFIGKSTSSGQVGFVPTRNIDP 328
AL YE + +L+F +GE ++I+ W++ S S+GQ G++P+ + P
Sbjct: 91 ALYDYESRTETDLSFKKGERLQIVNNTEG--DWWLAHSLSTGQTGYIPSNYVAP 142
>gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens]
Length = 482
Score = 36.6 bits (83), Expect = 0.16
Identities = 16/54 (29%), Positives = 32/54 (59%), Gaps = 2/54 (3%)
Query: 275 ALTGYEPGEKDELNFYQGESIEIIGFVIPGLQWFIGKSTSSGQVGFVPTRNIDP 328
AL YE +D+L+F++GE +I+ W+ +S ++G+ G++P+ + P
Sbjct: 89 ALYDYEARTEDDLSFHKGEKFQILN--SSEGDWWEARSLTTGETGYIPSNYVAP 140
>gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]
Length = 534
Score = 36.6 bits (83), Expect = 0.16
Identities = 16/54 (29%), Positives = 32/54 (59%), Gaps = 2/54 (3%)
Query: 275 ALTGYEPGEKDELNFYQGESIEIIGFVIPGLQWFIGKSTSSGQVGFVPTRNIDP 328
AL YE +D+L+F++GE +I+ W+ +S ++G+ G++P+ + P
Sbjct: 89 ALYDYEARTEDDLSFHKGEKFQILN--SSEGDWWEARSLTTGETGYIPSNYVAP 140
>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
Length = 537
Score = 36.6 bits (83), Expect = 0.16
Identities = 16/54 (29%), Positives = 32/54 (59%), Gaps = 2/54 (3%)
Query: 275 ALTGYEPGEKDELNFYQGESIEIIGFVIPGLQWFIGKSTSSGQVGFVPTRNIDP 328
AL YE +D+L+F++GE +I+ W+ +S ++G+ G++P+ + P
Sbjct: 89 ALYDYEARTEDDLSFHKGEKFQILN--SSEGDWWEARSLTTGETGYIPSNYVAP 140
>gi|222446607 SH3 domain containing ring finger 2 [Homo sapiens]
Length = 729
Score = 35.8 bits (81), Expect = 0.27
Identities = 27/98 (27%), Positives = 39/98 (39%), Gaps = 14/98 (14%)
Query: 232 VSALEPLPL-PFHQWFLKNYPGSCGLSRKRDWTGSYQIGRGRCKALTGYEPGEKDELNFY 290
VS P P+ P H + + PGS + AL Y DEL+
Sbjct: 354 VSTYHPAPVSPGHSTAVVSLPGS-----------QQHLSANMFVALHSYSAHGPDELDLQ 402
Query: 291 QGESIEIIGFVIPGLQWFIGKSTSSGQVGFVPTRNIDP 328
+GE + ++G G W G S +G+VG P + P
Sbjct: 403 KGEGVRVLGKCQDG--WLRGVSLVTGRVGIFPNNYVIP 438
>gi|112789548 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 35.4 bits (80), Expect = 0.35
Identities = 17/48 (35%), Positives = 27/48 (56%), Gaps = 3/48 (6%)
Query: 275 ALTGYEPGEKDELNFYQGESIEIIGFVIPGLQWFIGKSTSSGQVGFVP 322
AL YEP +L F +GE + I+ +W+ +S ++GQ GF+P
Sbjct: 68 ALHSYEPSHDGDLGFEKGEQLRILE---QSGEWWKAQSLTTGQEGFIP 112
>gi|112789546 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 35.4 bits (80), Expect = 0.35
Identities = 17/48 (35%), Positives = 27/48 (56%), Gaps = 3/48 (6%)
Query: 275 ALTGYEPGEKDELNFYQGESIEIIGFVIPGLQWFIGKSTSSGQVGFVP 322
AL YEP +L F +GE + I+ +W+ +S ++GQ GF+P
Sbjct: 68 ALHSYEPSHDGDLGFEKGEQLRILE---QSGEWWKAQSLTTGQEGFIP 112
>gi|4505331 N-ethylmaleimide-sensitive factor attachment protein,
gamma [Homo sapiens]
Length = 312
Score = 35.4 bits (80), Expect = 0.35
Identities = 50/214 (23%), Positives = 88/214 (41%), Gaps = 40/214 (18%)
Query: 978 EACI---TYHEHWLALAQQLRDREMEGRLLESLGQLYRNLNTARSLRRSLTCIKESLRIF 1034
+AC+ HE+ AL + E G +L+ + + L ++ I+++ ++
Sbjct: 56 DACLREAVAHENNRALFHAAKAYEQAGMMLKEM----------QKLPEAVQLIEKASMMY 105
Query: 1035 IDLGETDKAAEAWLGAGRLHYLMQEDELVELCLQAAIQTALKSEEPLLALKLYEEAGDVF 1094
++ G D AA A AG+L +++ +P A++LY++ +VF
Sbjct: 106 LENGTPDTAAMALERAGKL---------------------IENVDPEKAVQLYQQTANVF 144
Query: 1095 FNGTRHRHHAVEYYRAGAVPLARRLKAVRTELRIFNKLTELQISLEGYEKALEFATLAAR 1154
N R R AVE + L R + L I K + +E Y + T+A
Sbjct: 145 ENEERLR-QAVELLGKASRLLVRGRRFDEAALSI-QKEKNIYKEIENYPTCYK-KTIAQV 201
Query: 1155 LSTVTGDQRQELVAFHRLATVYYSLHMYEMAEDC 1188
L + R + VA R YS+ + +EDC
Sbjct: 202 LVHL---HRNDYVAAERCVRESYSIPGFNGSEDC 232
>gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens]
Length = 882
Score = 35.0 bits (79), Expect = 0.46
Identities = 20/59 (33%), Positives = 28/59 (47%), Gaps = 2/59 (3%)
Query: 275 ALTGYEPGEKDELNFYQGESIEIIGFVIPGLQWFIGKSTSSGQVGFVPTRNIDPDSYSP 333
AL Y+P + DEL ++GE ++ G WF G S +G G P + P S P
Sbjct: 471 ALYAYKPQKSDELELHKGEMYRVLEKCQDG--WFKGASLRTGVSGVFPGNYVTPVSRVP 527
>gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]
Length = 731
Score = 34.7 bits (78), Expect = 0.61
Identities = 25/81 (30%), Positives = 39/81 (48%), Gaps = 4/81 (4%)
Query: 255 GLSRKRDWTGSYQIGRGRCKALTGYEPGEKDELNFYQGESIEIIGFVIPGLQWFIGKSTS 314
G + KR+ S+ + RC A Y +KDEL+F +GE I + +V +W G+
Sbjct: 499 GGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYV--NEEWARGE--V 554
Query: 315 SGQVGFVPTRNIDPDSYSPMS 335
G+ G P ++P P S
Sbjct: 555 RGRTGIFPLNFVEPVEDYPTS 575
>gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]
Length = 767
Score = 34.7 bits (78), Expect = 0.61
Identities = 25/81 (30%), Positives = 39/81 (48%), Gaps = 4/81 (4%)
Query: 255 GLSRKRDWTGSYQIGRGRCKALTGYEPGEKDELNFYQGESIEIIGFVIPGLQWFIGKSTS 314
G + KR+ S+ + RC A Y +KDEL+F +GE I + +V +W G+
Sbjct: 535 GGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYV--NEEWARGE--V 590
Query: 315 SGQVGFVPTRNIDPDSYSPMS 335
G+ G P ++P P S
Sbjct: 591 RGRTGIFPLNFVEPVEDYPTS 611
>gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens]
Length = 790
Score = 34.7 bits (78), Expect = 0.61
Identities = 25/81 (30%), Positives = 39/81 (48%), Gaps = 4/81 (4%)
Query: 255 GLSRKRDWTGSYQIGRGRCKALTGYEPGEKDELNFYQGESIEIIGFVIPGLQWFIGKSTS 314
G + KR+ S+ + RC A Y +KDEL+F +GE I + +V +W G+
Sbjct: 558 GGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYV--NEEWARGE--V 613
Query: 315 SGQVGFVPTRNIDPDSYSPMS 335
G+ G P ++P P S
Sbjct: 614 RGRTGIFPLNFVEPVEDYPTS 634
>gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 34.3 bits (77), Expect = 0.79
Identities = 18/54 (33%), Positives = 28/54 (51%), Gaps = 2/54 (3%)
Query: 275 ALTGYEPGEKDELNFYQGESIEIIGFVIPGLQWFIGKSTSSGQVGFVPTRNIDP 328
AL YE +D+L F +GE I+ W+ +S SSG+ G +P+ + P
Sbjct: 84 ALYDYEARTEDDLTFTKGEKFHILNNTEG--DWWEARSLSSGKTGCIPSNYVAP 135
>gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 34.3 bits (77), Expect = 0.79
Identities = 18/54 (33%), Positives = 28/54 (51%), Gaps = 2/54 (3%)
Query: 275 ALTGYEPGEKDELNFYQGESIEIIGFVIPGLQWFIGKSTSSGQVGFVPTRNIDP 328
AL YE +D+L F +GE I+ W+ +S SSG+ G +P+ + P
Sbjct: 84 ALYDYEARTEDDLTFTKGEKFHILNNTEG--DWWEARSLSSGKTGCIPSNYVAP 135
>gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 34.3 bits (77), Expect = 0.79
Identities = 18/54 (33%), Positives = 28/54 (51%), Gaps = 2/54 (3%)
Query: 275 ALTGYEPGEKDELNFYQGESIEIIGFVIPGLQWFIGKSTSSGQVGFVPTRNIDP 328
AL YE +D+L F +GE I+ W+ +S SSG+ G +P+ + P
Sbjct: 84 ALYDYEARTEDDLTFTKGEKFHILNNTEG--DWWEARSLSSGKTGCIPSNYVAP 135
>gi|91105174 CD19 antigen [Homo sapiens]
Length = 556
Score = 33.9 bits (76), Expect = 1.0
Identities = 27/102 (26%), Positives = 44/102 (43%), Gaps = 10/102 (9%)
Query: 383 SIQNPPNDLSASQPEGFKEVRPGRAWEEHQAVGSRQSSSSE-------DSSLEEELLSAT 435
S NP +D+ A G + PG EE + G + S E DS+L ++ LS
Sbjct: 377 SYGNPSSDVQADGALGSRSP-PGVGPEEEEGEGYEEPDSEEDSEFYENDSNLGQDQLSQD 435
Query: 436 SDSYRLPEPDDL--DDPELLMDLSTGQEEEAENFAPILAFLD 475
Y PE + L +D + + + + E+ E P+ +D
Sbjct: 436 GSGYENPEDEPLGPEDEDSFSNAESYENEDEELTQPVARTMD 477
>gi|83415184 transmembrane and tetratricopeptide repeat containing 1
[Homo sapiens]
Length = 774
Score = 33.9 bits (76), Expect = 1.0
Identities = 56/256 (21%), Positives = 99/256 (38%), Gaps = 45/256 (17%)
Query: 956 LKSQLQATKSLCHFYSSVSPNPEACITYHEHWLALAQQLRDREMEGRLLESLGQLYRNLN 1015
LKSQ + +++ S+ PE Y LA+Q R +E E E +N
Sbjct: 450 LKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAE----EIYQTGIKNCP 505
Query: 1016 TARSLRRSLTCIKESLRIFIDLGETDKAAE--------------AWLGAGRLHYLMQEDE 1061
+ L + +D G +KA A + GRL+ + E+
Sbjct: 506 DSSDLHNNYGVF------LVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENS 559
Query: 1062 LVELCLQAAIQTALKSEEPLLALKLYEEAGDVFFNGTRHRHHAVEYYRAGAVPLARRLKA 1121
+ E + A+Q A K+E + G +++N R+ Y A A+ ++R
Sbjct: 560 MAEEWYKRALQVAHKAE-------ILSPLGALYYNTGRYEEALQIYQEAAALQPSQR--- 609
Query: 1122 VRTELRIFNKLTELQISLEGYEKALEFATLAARLSTVTGDQRQELVAFHRLATVYYSLHM 1181
ELR+ L ++ +++ G K E T + + ++ L + L+ +Y
Sbjct: 610 ---ELRL--ALAQV-LAVMGQTKEAEKMT-----NHIVSEETGCLECYRLLSAIYSKQEN 658
Query: 1182 YEMAEDCYLKTLSLCP 1197
++ A D K L L P
Sbjct: 659 HDKALDAIDKALQLKP 674
>gi|157671933 hypothetical protein LOC168090 [Homo sapiens]
Length = 469
Score = 33.9 bits (76), Expect = 1.0
Identities = 23/66 (34%), Positives = 30/66 (45%), Gaps = 3/66 (4%)
Query: 1080 PLLALKLYEEAGDVFFNGTRHRHHAVEYYRAGAVPLARRLKAVRTELRIFNKLTELQISL 1139
P L + Y+EAG GTR RHH V Y AGA R +R + + K L+
Sbjct: 180 PDLKVLCYQEAGS---RGTRDRHHYVSSYLAGATSADRYRMFLRFQKEVLAKQDLLKNDF 236
Query: 1140 EGYEKA 1145
G + A
Sbjct: 237 TGSKAA 242
>gi|5174573 myeloid/lymphoid or mixed-lineage leukemia trithorax
homolog 2 [Homo sapiens]
Length = 1210
Score = 33.5 bits (75), Expect = 1.3
Identities = 31/105 (29%), Positives = 48/105 (45%), Gaps = 8/105 (7%)
Query: 354 SDKQTECSSFLHTLARTDITSVY----RLSGFE---SIQNPPNDLSASQPEGFKEVRPGR 406
+ KQ + SS H+ ++ +S+ +LS E S Q P S+S P + P
Sbjct: 401 NQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEP 460
Query: 407 AWEEHQAVGSRQSSSSEDSSLEEELLSATSDSYRLPEPDDLDDPE 451
H + +S+S DSS + E S++SDS EP + PE
Sbjct: 461 VASAHSSSAESESTSDSDSSSDSESESSSSDSEE-NEPLETPAPE 504
>gi|213385323 anaphase-promoting complex subunit 5 isoform b [Homo
sapiens]
Length = 643
Score = 33.1 bits (74), Expect = 1.8
Identities = 27/90 (30%), Positives = 49/90 (54%), Gaps = 5/90 (5%)
Query: 739 MLRQALAACEELADRSTQRALCLILSKVYLEHRSPDGAIHYLSQALVLGQLLGEQE-SFE 797
+L++ L C++L + ++ L ++++Y SP A+ L QAL L + Q + E
Sbjct: 451 LLQKLLVHCQKLKNTEMVISVLLSVAELYWRSSSPTIALPMLLQALALSKEYRLQYLASE 510
Query: 798 SSLCLAWAYLLASQAKKALDVL----EPLL 823
+ L LA+A L+ ++AL +L EP+L
Sbjct: 511 TVLNLAFAQLILGIPEQALSLLHMAIEPIL 540
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 48,516,004
Number of Sequences: 37866
Number of extensions: 2106871
Number of successful extensions: 6160
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 11
Number of HSP's successfully gapped in prelim test: 62
Number of HSP's that attempted gapping in prelim test: 6004
Number of HSP's gapped (non-prelim): 140
length of query: 1288
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1174
effective length of database: 13,930,794
effective search space: 16354752156
effective search space used: 16354752156
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.