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Search of human proteins with 38372931
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|38372931 brevican isoform 2 [Homo sapiens]
(671 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|38372931 brevican isoform 2 [Homo sapiens] 1349 0.0
gi|38372935 brevican isoform 1 [Homo sapiens] 1306 0.0
gi|126090892 aggrecan isoform 2 precursor [Homo sapiens] 369 e-102
gi|126090883 aggrecan isoform 1 precursor [Homo sapiens] 369 e-102
gi|118600983 chondroitin sulfate proteoglycan 3 [Homo sapiens] 332 7e-91
gi|21361116 versican isoform 1 [Homo sapiens] 324 2e-88
gi|187607300 versican isoform 2 [Homo sapiens] 322 5e-88
gi|30102948 hyaluronan and proteoglycan link protein 3 [Homo sap... 233 6e-61
gi|4503053 hyaluronan and proteoglycan link protein 1 [Homo sapi... 224 2e-58
gi|30794472 hyaluronan and proteoglycan link protein 4 [Homo sap... 209 7e-54
gi|11141887 brain link protein-1 [Homo sapiens] 204 3e-52
gi|26051243 tumor necrosis factor, alpha-induced protein 6 precu... 64 6e-10
gi|61743978 stabilin 1 precursor [Homo sapiens] 62 1e-09
gi|61743980 stabilin 2 precursor [Homo sapiens] 60 7e-09
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 59 1e-08
gi|155030232 proline, glutamic acid and leucine rich protein 1 [... 55 2e-07
gi|119220598 apolipoprotein B48 receptor [Homo sapiens] 54 5e-07
gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo sa... 54 6e-07
gi|7657465 podocalyxin-like 2 [Homo sapiens] 53 1e-06
gi|38201621 eukaryotic translation initiation factor 4 gamma, 1 ... 52 2e-06
gi|38201627 eukaryotic translation initiation factor 4 gamma, 1 ... 52 2e-06
gi|38201625 eukaryotic translation initiation factor 4 gamma, 1 ... 52 2e-06
gi|38201623 eukaryotic translation initiation factor 4 gamma, 1 ... 52 2e-06
gi|38201619 eukaryotic translation initiation factor 4 gamma, 1 ... 52 2e-06
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e... 52 2e-06
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d... 52 2e-06
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ... 52 2e-06
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ... 52 2e-06
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof... 52 2e-06
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof... 52 2e-06
>gi|38372931 brevican isoform 2 [Homo sapiens]
Length = 671
Score = 1349 bits (3492), Expect = 0.0
Identities = 671/671 (100%), Positives = 671/671 (100%)
Query: 1 MAQLFLPLLAALVLAQAPAALADVLEGDSSEDRAFRVRIAGDAPLQGVLGGALTIPCHVH 60
MAQLFLPLLAALVLAQAPAALADVLEGDSSEDRAFRVRIAGDAPLQGVLGGALTIPCHVH
Sbjct: 1 MAQLFLPLLAALVLAQAPAALADVLEGDSSEDRAFRVRIAGDAPLQGVLGGALTIPCHVH 60
Query: 61 YLRPPPSRRAVLGSPRVKWTFLSRGREAEVLVARGVRVKVNEAYRFRVALPAYPASLTDV 120
YLRPPPSRRAVLGSPRVKWTFLSRGREAEVLVARGVRVKVNEAYRFRVALPAYPASLTDV
Sbjct: 61 YLRPPPSRRAVLGSPRVKWTFLSRGREAEVLVARGVRVKVNEAYRFRVALPAYPASLTDV 120
Query: 121 SLALSELRPNDSGIYRCEVQHGIDDSSDAVEVKVKGVVFLYREGSARYAFSFSGAQEACA 180
SLALSELRPNDSGIYRCEVQHGIDDSSDAVEVKVKGVVFLYREGSARYAFSFSGAQEACA
Sbjct: 121 SLALSELRPNDSGIYRCEVQHGIDDSSDAVEVKVKGVVFLYREGSARYAFSFSGAQEACA 180
Query: 181 RIGAHIATPEQLYAAYLGGYEQCDAGWLSDQTVRYPIQTPREACYGDMDGFPGVRNYGVV 240
RIGAHIATPEQLYAAYLGGYEQCDAGWLSDQTVRYPIQTPREACYGDMDGFPGVRNYGVV
Sbjct: 181 RIGAHIATPEQLYAAYLGGYEQCDAGWLSDQTVRYPIQTPREACYGDMDGFPGVRNYGVV 240
Query: 241 DPDDLYDVYCYAEDLNGELFLGDPPEKLTLEEARAYCQERGAEIATTGQLYAAWDGGLDH 300
DPDDLYDVYCYAEDLNGELFLGDPPEKLTLEEARAYCQERGAEIATTGQLYAAWDGGLDH
Sbjct: 241 DPDDLYDVYCYAEDLNGELFLGDPPEKLTLEEARAYCQERGAEIATTGQLYAAWDGGLDH 300
Query: 301 CSPGWLADGSVRYPIVTPSQRCGGGLPGVKTLFLFPNQTGFPNKHSRFNVYCFRDSAQPS 360
CSPGWLADGSVRYPIVTPSQRCGGGLPGVKTLFLFPNQTGFPNKHSRFNVYCFRDSAQPS
Sbjct: 301 CSPGWLADGSVRYPIVTPSQRCGGGLPGVKTLFLFPNQTGFPNKHSRFNVYCFRDSAQPS 360
Query: 361 AIPEASNPASNPASDGLEAIVTVTETLEELQLPQEATESESRGAIYSIPIMEDGGGGSST 420
AIPEASNPASNPASDGLEAIVTVTETLEELQLPQEATESESRGAIYSIPIMEDGGGGSST
Sbjct: 361 AIPEASNPASNPASDGLEAIVTVTETLEELQLPQEATESESRGAIYSIPIMEDGGGGSST 420
Query: 421 PEDPAEAPRTLLEFETQSMVPPTGFSEEEGKALEEEEKYEDEEEKEEEEEEEEVEDEALW 480
PEDPAEAPRTLLEFETQSMVPPTGFSEEEGKALEEEEKYEDEEEKEEEEEEEEVEDEALW
Sbjct: 421 PEDPAEAPRTLLEFETQSMVPPTGFSEEEGKALEEEEKYEDEEEKEEEEEEEEVEDEALW 480
Query: 481 AWPSELSSPGPEASLPTEPAAQEESLSQAPARAVLQPGASPLPDGESEASRPPRVHGPPT 540
AWPSELSSPGPEASLPTEPAAQEESLSQAPARAVLQPGASPLPDGESEASRPPRVHGPPT
Sbjct: 481 AWPSELSSPGPEASLPTEPAAQEESLSQAPARAVLQPGASPLPDGESEASRPPRVHGPPT 540
Query: 541 ETLPTPRERNLASPSPSTLVEAREVGEATGGPELSGVPRGESEETGSSEGAPSLLPATRA 600
ETLPTPRERNLASPSPSTLVEAREVGEATGGPELSGVPRGESEETGSSEGAPSLLPATRA
Sbjct: 541 ETLPTPRERNLASPSPSTLVEAREVGEATGGPELSGVPRGESEETGSSEGAPSLLPATRA 600
Query: 601 PEGTRELEAPSEDNSGRTAPAGTSVQAQPVLPTDSASRGGVAVVPASGNSAQGSTALSIL 660
PEGTRELEAPSEDNSGRTAPAGTSVQAQPVLPTDSASRGGVAVVPASGNSAQGSTALSIL
Sbjct: 601 PEGTRELEAPSEDNSGRTAPAGTSVQAQPVLPTDSASRGGVAVVPASGNSAQGSTALSIL 660
Query: 661 LLFFPLQLWVT 671
LLFFPLQLWVT
Sbjct: 661 LLFFPLQLWVT 671
>gi|38372935 brevican isoform 1 [Homo sapiens]
Length = 911
Score = 1306 bits (3379), Expect = 0.0
Identities = 648/649 (99%), Positives = 649/649 (100%)
Query: 1 MAQLFLPLLAALVLAQAPAALADVLEGDSSEDRAFRVRIAGDAPLQGVLGGALTIPCHVH 60
MAQLFLPLLAALVLAQAPAALADVLEGDSSEDRAFRVRIAGDAPLQGVLGGALTIPCHVH
Sbjct: 1 MAQLFLPLLAALVLAQAPAALADVLEGDSSEDRAFRVRIAGDAPLQGVLGGALTIPCHVH 60
Query: 61 YLRPPPSRRAVLGSPRVKWTFLSRGREAEVLVARGVRVKVNEAYRFRVALPAYPASLTDV 120
YLRPPPSRRAVLGSPRVKWTFLSRGREAEVLVARGVRVKVNEAYRFRVALPAYPASLTDV
Sbjct: 61 YLRPPPSRRAVLGSPRVKWTFLSRGREAEVLVARGVRVKVNEAYRFRVALPAYPASLTDV 120
Query: 121 SLALSELRPNDSGIYRCEVQHGIDDSSDAVEVKVKGVVFLYREGSARYAFSFSGAQEACA 180
SLALSELRPNDSGIYRCEVQHGIDDSSDAVEVKVKGVVFLYREGSARYAFSFSGAQEACA
Sbjct: 121 SLALSELRPNDSGIYRCEVQHGIDDSSDAVEVKVKGVVFLYREGSARYAFSFSGAQEACA 180
Query: 181 RIGAHIATPEQLYAAYLGGYEQCDAGWLSDQTVRYPIQTPREACYGDMDGFPGVRNYGVV 240
RIGAHIATPEQLYAAYLGGYEQCDAGWLSDQTVRYPIQTPREACYGDMDGFPGVRNYGVV
Sbjct: 181 RIGAHIATPEQLYAAYLGGYEQCDAGWLSDQTVRYPIQTPREACYGDMDGFPGVRNYGVV 240
Query: 241 DPDDLYDVYCYAEDLNGELFLGDPPEKLTLEEARAYCQERGAEIATTGQLYAAWDGGLDH 300
DPDDLYDVYCYAEDLNGELFLGDPPEKLTLEEARAYCQERGAEIATTGQLYAAWDGGLDH
Sbjct: 241 DPDDLYDVYCYAEDLNGELFLGDPPEKLTLEEARAYCQERGAEIATTGQLYAAWDGGLDH 300
Query: 301 CSPGWLADGSVRYPIVTPSQRCGGGLPGVKTLFLFPNQTGFPNKHSRFNVYCFRDSAQPS 360
CSPGWLADGSVRYPIVTPSQRCGGGLPGVKTLFLFPNQTGFPNKHSRFNVYCFRDSAQPS
Sbjct: 301 CSPGWLADGSVRYPIVTPSQRCGGGLPGVKTLFLFPNQTGFPNKHSRFNVYCFRDSAQPS 360
Query: 361 AIPEASNPASNPASDGLEAIVTVTETLEELQLPQEATESESRGAIYSIPIMEDGGGGSST 420
AIPEASNPASNPASDGLEAIVTVTETLEELQLPQEATESESRGAIYSIPIMEDGGGGSST
Sbjct: 361 AIPEASNPASNPASDGLEAIVTVTETLEELQLPQEATESESRGAIYSIPIMEDGGGGSST 420
Query: 421 PEDPAEAPRTLLEFETQSMVPPTGFSEEEGKALEEEEKYEDEEEKEEEEEEEEVEDEALW 480
PEDPAEAPRTLLEFETQSMVPPTGFSEEEGKALEEEEKYEDEEEKEEEEEEEEVEDEALW
Sbjct: 421 PEDPAEAPRTLLEFETQSMVPPTGFSEEEGKALEEEEKYEDEEEKEEEEEEEEVEDEALW 480
Query: 481 AWPSELSSPGPEASLPTEPAAQEESLSQAPARAVLQPGASPLPDGESEASRPPRVHGPPT 540
AWPSELSSPGPEASLPTEPAAQEESLSQAPARAVLQPGASPLPDGESEASRPPRVHGPPT
Sbjct: 481 AWPSELSSPGPEASLPTEPAAQEESLSQAPARAVLQPGASPLPDGESEASRPPRVHGPPT 540
Query: 541 ETLPTPRERNLASPSPSTLVEAREVGEATGGPELSGVPRGESEETGSSEGAPSLLPATRA 600
ETLPTPRERNLASPSPSTLVEAREVGEATGGPELSGVPRGESEETGSSEGAPSLLPATRA
Sbjct: 541 ETLPTPRERNLASPSPSTLVEAREVGEATGGPELSGVPRGESEETGSSEGAPSLLPATRA 600
Query: 601 PEGTRELEAPSEDNSGRTAPAGTSVQAQPVLPTDSASRGGVAVVPASGN 649
PEGTRELEAPSEDNSGRTAPAGTSVQAQPVLPTDSASRGGVAVVPASG+
Sbjct: 601 PEGTRELEAPSEDNSGRTAPAGTSVQAQPVLPTDSASRGGVAVVPASGD 649
>gi|126090892 aggrecan isoform 2 precursor [Homo sapiens]
Length = 2416
Score = 369 bits (946), Expect = e-102
Identities = 203/432 (46%), Positives = 265/432 (61%), Gaps = 22/432 (5%)
Query: 29 SSEDRAFRVRIAGDAPLQGVLGGALTIPCH----VHYLRPPPSRRAVLGSPRVKWTFLSR 84
S D + V I +PL+ +LG +LTIPC+ +H + PS + +PR+KW+ +S+
Sbjct: 23 SDHDNSLSVSIPQPSPLRVLLGTSLTIPCYFIDPMHPVTTAPSTAPL--APRIKWSRVSK 80
Query: 85 GREAEVLVARGVRVKVNEAYRFRVALPAYPASLTDVSLALSELRPNDSGIYRCEVQHGID 144
+E +LVA RV+VN AY+ +V+LP YPA +D +L + LR NDSG+YRCEV HGI+
Sbjct: 81 EKEVVLLVATEGRVRVNSAYQDKVSLPNYPAIPSDATLEVQSLRSNDSGVYRCEVMHGIE 140
Query: 145 DSSDAVEVKVKGVVFLYREGSARYAFSFSGAQEACARIGAHIATPEQLYAAYLGGYEQCD 204
DS +EV VKG+VF YR S RY F AQ AC + A IATPEQL AAY G+ QCD
Sbjct: 141 DSEATLEVVVKGIVFHYRAISTRYTLDFDRAQRACLQNSAIIATPEQLQAAYEDGFHQCD 200
Query: 205 AGWLSDQTVRYPIQTPREACYGDMDGFPGVRNYGVVDPDDLYDVYCYAEDLNGELFLGDP 264
AGWL+DQTVRYPI TPRE CYGD D FPGVR YG+ D ++ YDVYC+AE++ GE+F
Sbjct: 201 AGWLADQTVRYPIHTPREGCYGDKDEFPGVRTYGIRDTNETYDVYCFAEEMEGEVFYATS 260
Query: 265 PEKLTLEEARAYCQERGAEIATTGQLYAAWDGGLDHCSPGWLADGSVRYPIVTPSQRCGG 324
PEK T +EA C+ GA +ATTGQLY AW G+D CS GWLAD SVRYPI CGG
Sbjct: 261 PEKFTFQEAANECRRLGARLATTGQLYLAWQAGMDMCSAGWLADRSVRYPISKARPNCGG 320
Query: 325 GLPGVKTLFLFPNQTGFPNKHSRFNVYCFRDSAQPSAIPEASNPASNPASDGLEAIVTVT 384
L GV+T+++ NQTG+P+ SR++ C+ IPE N + + + TVT
Sbjct: 321 NLLGVRTVYVHANQTGYPDPSSRYDAICYTGEDFVD-IPE--NFFGVGGEEDI-TVQTVT 376
Query: 385 ETLEELQLPQEATESESRGAIYSI--PIMEDGGGGSSTPEDPAEAPRTLLEFETQSMVPP 442
EL LP+ TE E+RG++ PI E S +P +P E F +
Sbjct: 377 WPDMELPLPRNITEGEARGSVILTVKPIFE----VSPSPLEPEE------PFTFAPEIGA 426
Query: 443 TGFSEEEGKALE 454
T F+E E + E
Sbjct: 427 TAFAEVENETGE 438
Score = 291 bits (745), Expect = 1e-78
Identities = 195/514 (37%), Positives = 250/514 (48%), Gaps = 58/514 (11%)
Query: 156 GVVFLYREGSARYAFSFSGAQEACARIGAHIATPEQLYAAYLGGYEQCDAGWLSDQTVRY 215
GVVF YR G RY+ +F AQ+AC R GA IA+PEQL AAY GYEQCDAGWL DQTVRY
Sbjct: 477 GVVFHYRPGPTRYSLTFEEAQQACLRTGAVIASPEQLQAAYEAGYEQCDAGWLRDQTVRY 536
Query: 216 PIQTPREACYGDMDGFPGVRNYGVVDPDDLYDVYCYAEDLNGELFLGDPPEKLTLEEARA 275
PI +PR C GD D PGVR YGV + YDVYC+ + L GE+F E+ T +EA
Sbjct: 537 PIVSPRTPCVGDKDSSPGVRTYGVRPSTETYDVYCFVDRLEGEVFFATRLEQFTFQEALE 596
Query: 276 YCQERGAEIATTGQLYAAWDGGLDHCSPGWLADGSVRYPIVTPSQRCGGGLPGVKTLFLF 335
+C+ A +ATTGQLYAAW GLD C GWLADGS+RYPIVTP CGG PGV+T++L+
Sbjct: 597 FCESHNATLATTGQLYAAWSRGLDKCYAGWLADGSLRYPIVTPRPACGGDKPGVRTVYLY 656
Query: 336 PNQTGFPNKHSRFNVYCFRD-SAQPSAIPEASNPASNPASDGLEAIVTVTETLEELQLPQ 394
PNQTG P+ SR + +CFR SA PS E ++P+ G+E + VT+ +
Sbjct: 657 PNQTGLPDPLSRHHAFCFRGISAVPSPGEEEGGTPTSPS--GVEEWI-VTQVVP------ 707
Query: 395 EATESESRGAIYSIPIMEDGGGGSSTPEDPAEAPRTLLEFETQS--------MVPPTGFS 446
+ ++P+ E+ T P+ +LEF T+ P G S
Sbjct: 708 ---------GVAAVPVEEE------TTAVPSGETTAILEFTTEPENQTEWEPAYTPVGTS 752
Query: 447 EEEGKALEEEEKYEDEEEKEEEEEEEEVEDEALWAWPSELSSPGPEASLPTEPAAQEESL 506
G EE E EV + PSE+ P E S EP
Sbjct: 753 PLPGILPTWPPTGAATEESTEGPSATEVPSASEEPSPSEVPFPSEEPSPSEEPFP----- 807
Query: 507 SQAPARAV-LQPGASPLPDGESEASRPPRVHGPPTETLPTPRERNLASPSPSTLVEAREV 565
S P +V L P P P E S P P TP SP + E
Sbjct: 808 SVRPFPSVELFPSEEPFPSKEPSPSEEPSASEEPY----TP------SPPVPSWTELPSS 857
Query: 566 GEATGGPELSGVPRGESEETGSSEGAPSLLPATRAPEGTRELEAPSED--NSGRTAPAGT 623
GE +G P++SG G + +G + + L G R PS D +SG T+ G+
Sbjct: 858 GEESGAPDVSGDFTGSGDVSGHLDFSGQL-------SGDRASGLPSGDLDSSGLTSTVGS 910
Query: 624 SVQAQPVLPTDSASRGGVAVVPASGNSAQGSTAL 657
+ + LP+ R P G G+ L
Sbjct: 911 GLPVESGLPSGDEERIEWPSTPTVGELPSGAEIL 944
Score = 39.3 bits (90), Expect = 0.012
Identities = 49/184 (26%), Positives = 67/184 (36%), Gaps = 33/184 (17%)
Query: 486 LSSPGPEASLPTEPAAQEESLSQAPARAVLQPGASPLPDGESEASRPPRVHGPPT----- 540
+S G + LP+ S P+ L AS PD E V G P+
Sbjct: 1572 ISGAGEISGLPSSELDISGRASGLPSGTELSGQASGSPDVSGEIPGLFGVSGQPSGFPDT 1631
Query: 541 --ETLPTPRERNLASPSPSTLVEAREV--------------GEATGGPELSGVPRGESEE 584
ET L+S P EA V GE +G P+LSG P G
Sbjct: 1632 SGETSGVTELSGLSSGQPGISGEASGVLYGTSQPFGITDLSGETSGVPDLSGQPSGLPGF 1691
Query: 585 TGSSEGAPSLLPATRAPEGTRELEAPSEDNSGRTAPAGTSVQAQPVLPTDSASRGGVAVV 644
+G++ G P L+ T + G ++SG T + V+ V PT G+ V
Sbjct: 1692 SGATSGVPDLVSGTTSGSG---------ESSGITFVDTSLVE---VAPTTFKEEEGLGSV 1739
Query: 645 PASG 648
SG
Sbjct: 1740 ELSG 1743
Score = 34.7 bits (78), Expect = 0.29
Identities = 42/133 (31%), Positives = 55/133 (41%), Gaps = 16/133 (12%)
Query: 498 EPAAQEESLSQAPARAVLQPGASPLPDGESEASRPPRVHGPPTETLPTPRERNLASPSP- 556
E ++ ES S+ A GAS P+ E S P + +ET E NL S
Sbjct: 1978 EVSSVPESSSETSAYPEAGFGASAAPEASREDSGSPDL----SETTSAFHEANLERSSGL 2033
Query: 557 ----STLVEAREVGEATGGPELSGVPRGESEETGSSEGAPSLLPATRAPEGTRELEAPSE 612
STL + GEA+ PE+SG S+ + G PS AT G R S
Sbjct: 2034 GVSGSTLTF--QEGEASAAPEVSGESTTTSDVGTEAPGLPS---ATPTASGDR--TEISG 2086
Query: 613 DNSGRTAPAGTSV 625
D SG T+ G +
Sbjct: 2087 DLSGHTSQLGVVI 2099
Score = 33.9 bits (76), Expect = 0.50
Identities = 41/155 (26%), Positives = 57/155 (36%), Gaps = 17/155 (10%)
Query: 508 QAPARAVLQPGASPLPDGESEASRPPR--------VHGPPTETLPTPRERNLASPSPSTL 559
QAP + L G S G S PP G PT +L + + S ++
Sbjct: 1504 QAPETSGLPSGFSGEYSGVDLGSGPPSGLPDFSGLPSGFPTVSLVDSTLVEVVTASTASE 1563
Query: 560 VEAREVGEATGGPELSGVPRGESEETGSSEGAPSLLPATRAPEGTRELEAPSEDNSGRTA 619
+E R +G E+SG+P E + +G + G PS + G S D SG
Sbjct: 1564 LEGRGTIGISGAGEISGLPSSELDISGRASGLPSGTELSGQASG-------SPDVSGE-I 1615
Query: 620 PAGTSVQAQPV-LPTDSASRGGVAVVPASGNSAQG 653
P V QP P S GV + + G
Sbjct: 1616 PGLFGVSGQPSGFPDTSGETSGVTELSGLSSGQPG 1650
Score = 32.3 bits (72), Expect = 1.5
Identities = 49/151 (32%), Positives = 67/151 (44%), Gaps = 25/151 (16%)
Query: 485 ELSSPGPE--ASLPT----EPAAQE-ESLSQAPARAVLQPGA------SPLPDGESEASR 531
E ++PG E + LP+ E AA E +S P+ VL+ A S LP GE +
Sbjct: 1097 ETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETA 1156
Query: 532 PPRVHGPPTETLPTPRERNLASPSPSTL--VEAREVGE--ATGGPELSGVPRGESEETGS 587
P V LP+ A+P + + + EV E A G ++SG+P GE ET
Sbjct: 1157 APGVED--ISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLET-- 1212
Query: 588 SEGAPSLLPATRAPEG-TRELEAPS-EDNSG 616
AP + + P G E AP ED SG
Sbjct: 1213 --AAPGVEDISGLPSGEVLETAAPGVEDISG 1241
Score = 32.0 bits (71), Expect = 1.9
Identities = 46/151 (30%), Positives = 65/151 (43%), Gaps = 25/151 (16%)
Query: 485 ELSSPGPE--ASLPTEPAAQE-----ESLSQAPARAVLQPGA------SPLPDGESEASR 531
E ++PG E + LP+ + E +S P+ VL+ A S LP GE +
Sbjct: 1059 ETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETA 1118
Query: 532 PPRVHGPPTETLPTPRERNLASPSPSTL--VEAREVGE--ATGGPELSGVPRGESEETGS 587
P V LP+ A+P + + + EV E A G ++SG+P GE ET
Sbjct: 1119 APGVED--ISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLET-- 1174
Query: 588 SEGAPSLLPATRAPEG-TRELEAPS-EDNSG 616
AP + + P G E AP ED SG
Sbjct: 1175 --AAPGVEDISGLPSGEVLETAAPGVEDISG 1203
Score = 32.0 bits (71), Expect = 1.9
Identities = 34/114 (29%), Positives = 48/114 (42%), Gaps = 11/114 (9%)
Query: 504 ESLSQAPARAVLQPGASPLPDGESEASRPPRVHGPPTETLPTPRERNLASPSPSTLVEAR 563
E +S P+ V++ AS + D S G ET + E PS ++E
Sbjct: 1371 EDISGLPSGEVVETSASGIEDVSELPS------GEGLETSASGVEDLSRLPSGEEVLEI- 1423
Query: 564 EVGEATGGPELSGVPRG-ESEETGSSEGAPSLLPATRAPEGTRELEAPSEDNSG 616
A+G +LSG+P G E ET +SE L EG + +ED SG
Sbjct: 1424 ---SASGFGDLSGLPSGGEGLETSASEVGTDLSGLPSGREGLETSASGAEDLSG 1474
Score = 31.6 bits (70), Expect = 2.5
Identities = 47/151 (31%), Positives = 66/151 (43%), Gaps = 25/151 (16%)
Query: 485 ELSSPGPE--ASLPTEPAAQE-----ESLSQAPARAVLQ---PGA---SPLPDGESEASR 531
E ++PG E + LP+ + E +S P+ VL+ PG S LP GE +
Sbjct: 1021 ETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETT 1080
Query: 532 PPRVHGPPTETLPTPRERNLASPSPSTL--VEAREVGE--ATGGPELSGVPRGESEETGS 587
P V LP+ A+P + + + EV E A G ++SG+P GE ET
Sbjct: 1081 APGVED--ISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLET-- 1136
Query: 588 SEGAPSLLPATRAPEG-TRELEAPS-EDNSG 616
AP + + P G E AP ED SG
Sbjct: 1137 --AAPGVEDISGLPSGEVLETAAPGVEDISG 1165
Score = 31.6 bits (70), Expect = 2.5
Identities = 50/162 (30%), Positives = 72/162 (44%), Gaps = 28/162 (17%)
Query: 485 ELSSPGPE--ASLPT----EPAAQE-ESLSQAPARAVLQPGA------SPLPDGESEASR 531
E ++PG E + LP+ E AA E +S P+ VL+ A S LP GE +
Sbjct: 1230 ETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETT 1289
Query: 532 PPRVHGPPTETLPTPRERNLASPSPSTL--VEAREVGEAT--GGPELSGVPRGESEETGS 587
P V LP+ +P + + + EV E T G E+SG+P GE ET +
Sbjct: 1290 APGVE--EISGLPSGEVLETTAPGVDEISGLPSGEVLETTAPGVEEISGLPSGEVLETST 1347
Query: 588 SEGAPSLLPATRAPEGTRELE---APSEDNSGRTAPAGTSVQ 626
S ++ + P G LE + ED SG P+G V+
Sbjct: 1348 S----AVGDLSGLPSGGEVLEISVSGVEDISG--LPSGEVVE 1383
Score = 31.6 bits (70), Expect = 2.5
Identities = 50/181 (27%), Positives = 74/181 (40%), Gaps = 28/181 (15%)
Query: 489 PGPEASLPTEPAAQEESLSQAPARAVLQ---PGA---SPLPDGESEASRPPRVHG----P 538
P E T P +E +S P+ VL+ PG S LP GE + P V P
Sbjct: 1281 PSGEVLETTAPGVEE--ISGLPSGEVLETTAPGVDEISGLPSGEVLETTAPGVEEISGLP 1338
Query: 539 PTETLPTPRERNLASPSPSTLVEAREVGE--ATGGPELSGVPRGESEETGSSEGAPSLLP 596
E L T A S L EV E +G ++SG+P GE ET +S +
Sbjct: 1339 SGEVLETSTS---AVGDLSGLPSGGEVLEISVSGVEDISGLPSGEVVETSAS----GIED 1391
Query: 597 ATRAPEGT-RELEAPSEDNSGRTAPAGTSVQAQPVLPTDSASRGGVAVVPASGNSAQGST 655
+ P G E A ++ R P+G + VL ++ G ++ +P+ G + S
Sbjct: 1392 VSELPSGEGLETSASGVEDLSR-LPSG-----EEVLEISASGFGDLSGLPSGGEGLETSA 1445
Query: 656 A 656
+
Sbjct: 1446 S 1446
Score = 30.8 bits (68), Expect = 4.2
Identities = 46/151 (30%), Positives = 65/151 (43%), Gaps = 25/151 (16%)
Query: 485 ELSSPGPE--ASLPTEPAAQE-----ESLSQAPARAVLQ---PGA---SPLPDGESEASR 531
E ++PG E + LP+ + E +S P+ VL+ PG S LP GE +
Sbjct: 983 ETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETT 1042
Query: 532 PPRVHGPPTETLPTPRERNLASPSPSTL--VEAREVGEAT--GGPELSGVPRGESEETGS 587
P V LP+ +P + + + EV E T G ++SG+P GE ET
Sbjct: 1043 APGVED--ISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLET-- 1098
Query: 588 SEGAPSLLPATRAPEG-TRELEAPS-EDNSG 616
AP + + P G E AP ED SG
Sbjct: 1099 --AAPGVEDISGLPSGEVLETAAPGVEDISG 1127
Score = 29.6 bits (65), Expect = 9.4
Identities = 35/126 (27%), Positives = 51/126 (40%), Gaps = 15/126 (11%)
Query: 491 PEASLPTEPAAQEESLSQAPARAVLQPGASP------LPDGES----EASRPPRVHGPPT 540
P + A+ E +S+ P+ L+ AS LP GE AS + G P+
Sbjct: 1377 PSGEVVETSASGIEDVSELPSGEGLETSASGVEDLSRLPSGEEVLEISASGFGDLSGLPS 1436
Query: 541 ETLPTPRERNLASPSPSTLVEAREVGE--ATGGPELSGVPRGESEETGSSEGAPSLLPAT 598
+ S L RE E A+G +LSG+P G+ + GS+ G L
Sbjct: 1437 GGEGLETSASEVGTDLSGLPSGREGLETSASGAEDLSGLPSGKEDLVGSASGD---LDLG 1493
Query: 599 RAPEGT 604
+ P GT
Sbjct: 1494 KLPSGT 1499
>gi|126090883 aggrecan isoform 1 precursor [Homo sapiens]
Length = 2317
Score = 369 bits (946), Expect = e-102
Identities = 203/432 (46%), Positives = 265/432 (61%), Gaps = 22/432 (5%)
Query: 29 SSEDRAFRVRIAGDAPLQGVLGGALTIPCH----VHYLRPPPSRRAVLGSPRVKWTFLSR 84
S D + V I +PL+ +LG +LTIPC+ +H + PS + +PR+KW+ +S+
Sbjct: 23 SDHDNSLSVSIPQPSPLRVLLGTSLTIPCYFIDPMHPVTTAPSTAPL--APRIKWSRVSK 80
Query: 85 GREAEVLVARGVRVKVNEAYRFRVALPAYPASLTDVSLALSELRPNDSGIYRCEVQHGID 144
+E +LVA RV+VN AY+ +V+LP YPA +D +L + LR NDSG+YRCEV HGI+
Sbjct: 81 EKEVVLLVATEGRVRVNSAYQDKVSLPNYPAIPSDATLEVQSLRSNDSGVYRCEVMHGIE 140
Query: 145 DSSDAVEVKVKGVVFLYREGSARYAFSFSGAQEACARIGAHIATPEQLYAAYLGGYEQCD 204
DS +EV VKG+VF YR S RY F AQ AC + A IATPEQL AAY G+ QCD
Sbjct: 141 DSEATLEVVVKGIVFHYRAISTRYTLDFDRAQRACLQNSAIIATPEQLQAAYEDGFHQCD 200
Query: 205 AGWLSDQTVRYPIQTPREACYGDMDGFPGVRNYGVVDPDDLYDVYCYAEDLNGELFLGDP 264
AGWL+DQTVRYPI TPRE CYGD D FPGVR YG+ D ++ YDVYC+AE++ GE+F
Sbjct: 201 AGWLADQTVRYPIHTPREGCYGDKDEFPGVRTYGIRDTNETYDVYCFAEEMEGEVFYATS 260
Query: 265 PEKLTLEEARAYCQERGAEIATTGQLYAAWDGGLDHCSPGWLADGSVRYPIVTPSQRCGG 324
PEK T +EA C+ GA +ATTGQLY AW G+D CS GWLAD SVRYPI CGG
Sbjct: 261 PEKFTFQEAANECRRLGARLATTGQLYLAWQAGMDMCSAGWLADRSVRYPISKARPNCGG 320
Query: 325 GLPGVKTLFLFPNQTGFPNKHSRFNVYCFRDSAQPSAIPEASNPASNPASDGLEAIVTVT 384
L GV+T+++ NQTG+P+ SR++ C+ IPE N + + + TVT
Sbjct: 321 NLLGVRTVYVHANQTGYPDPSSRYDAICYTGEDFVD-IPE--NFFGVGGEEDI-TVQTVT 376
Query: 385 ETLEELQLPQEATESESRGAIYSI--PIMEDGGGGSSTPEDPAEAPRTLLEFETQSMVPP 442
EL LP+ TE E+RG++ PI E S +P +P E F +
Sbjct: 377 WPDMELPLPRNITEGEARGSVILTVKPIFE----VSPSPLEPEE------PFTFAPEIGA 426
Query: 443 TGFSEEEGKALE 454
T F+E E + E
Sbjct: 427 TAFAEVENETGE 438
Score = 291 bits (745), Expect = 1e-78
Identities = 195/514 (37%), Positives = 250/514 (48%), Gaps = 58/514 (11%)
Query: 156 GVVFLYREGSARYAFSFSGAQEACARIGAHIATPEQLYAAYLGGYEQCDAGWLSDQTVRY 215
GVVF YR G RY+ +F AQ+AC R GA IA+PEQL AAY GYEQCDAGWL DQTVRY
Sbjct: 477 GVVFHYRPGPTRYSLTFEEAQQACLRTGAVIASPEQLQAAYEAGYEQCDAGWLRDQTVRY 536
Query: 216 PIQTPREACYGDMDGFPGVRNYGVVDPDDLYDVYCYAEDLNGELFLGDPPEKLTLEEARA 275
PI +PR C GD D PGVR YGV + YDVYC+ + L GE+F E+ T +EA
Sbjct: 537 PIVSPRTPCVGDKDSSPGVRTYGVRPSTETYDVYCFVDRLEGEVFFATRLEQFTFQEALE 596
Query: 276 YCQERGAEIATTGQLYAAWDGGLDHCSPGWLADGSVRYPIVTPSQRCGGGLPGVKTLFLF 335
+C+ A +ATTGQLYAAW GLD C GWLADGS+RYPIVTP CGG PGV+T++L+
Sbjct: 597 FCESHNATLATTGQLYAAWSRGLDKCYAGWLADGSLRYPIVTPRPACGGDKPGVRTVYLY 656
Query: 336 PNQTGFPNKHSRFNVYCFRD-SAQPSAIPEASNPASNPASDGLEAIVTVTETLEELQLPQ 394
PNQTG P+ SR + +CFR SA PS E ++P+ G+E + VT+ +
Sbjct: 657 PNQTGLPDPLSRHHAFCFRGISAVPSPGEEEGGTPTSPS--GVEEWI-VTQVVP------ 707
Query: 395 EATESESRGAIYSIPIMEDGGGGSSTPEDPAEAPRTLLEFETQS--------MVPPTGFS 446
+ ++P+ E+ T P+ +LEF T+ P G S
Sbjct: 708 ---------GVAAVPVEEE------TTAVPSGETTAILEFTTEPENQTEWEPAYTPVGTS 752
Query: 447 EEEGKALEEEEKYEDEEEKEEEEEEEEVEDEALWAWPSELSSPGPEASLPTEPAAQEESL 506
G EE E EV + PSE+ P E S EP
Sbjct: 753 PLPGILPTWPPTGAATEESTEGPSATEVPSASEEPSPSEVPFPSEEPSPSEEPFP----- 807
Query: 507 SQAPARAV-LQPGASPLPDGESEASRPPRVHGPPTETLPTPRERNLASPSPSTLVEAREV 565
S P +V L P P P E S P P TP SP + E
Sbjct: 808 SVRPFPSVELFPSEEPFPSKEPSPSEEPSASEEPY----TP------SPPVPSWTELPSS 857
Query: 566 GEATGGPELSGVPRGESEETGSSEGAPSLLPATRAPEGTRELEAPSED--NSGRTAPAGT 623
GE +G P++SG G + +G + + L G R PS D +SG T+ G+
Sbjct: 858 GEESGAPDVSGDFTGSGDVSGHLDFSGQL-------SGDRASGLPSGDLDSSGLTSTVGS 910
Query: 624 SVQAQPVLPTDSASRGGVAVVPASGNSAQGSTAL 657
+ + LP+ R P G G+ L
Sbjct: 911 GLPVESGLPSGDEERIEWPSTPTVGELPSGAEIL 944
Score = 39.3 bits (90), Expect = 0.012
Identities = 49/184 (26%), Positives = 67/184 (36%), Gaps = 33/184 (17%)
Query: 486 LSSPGPEASLPTEPAAQEESLSQAPARAVLQPGASPLPDGESEASRPPRVHGPPT----- 540
+S G + LP+ S P+ L AS PD E V G P+
Sbjct: 1572 ISGAGEISGLPSSELDISGRASGLPSGTELSGQASGSPDVSGEIPGLFGVSGQPSGFPDT 1631
Query: 541 --ETLPTPRERNLASPSPSTLVEAREV--------------GEATGGPELSGVPRGESEE 584
ET L+S P EA V GE +G P+LSG P G
Sbjct: 1632 SGETSGVTELSGLSSGQPGISGEASGVLYGTSQPFGITDLSGETSGVPDLSGQPSGLPGF 1691
Query: 585 TGSSEGAPSLLPATRAPEGTRELEAPSEDNSGRTAPAGTSVQAQPVLPTDSASRGGVAVV 644
+G++ G P L+ T + G ++SG T + V+ V PT G+ V
Sbjct: 1692 SGATSGVPDLVSGTTSGSG---------ESSGITFVDTSLVE---VAPTTFKEEEGLGSV 1739
Query: 645 PASG 648
SG
Sbjct: 1740 ELSG 1743
Score = 34.7 bits (78), Expect = 0.29
Identities = 42/133 (31%), Positives = 55/133 (41%), Gaps = 16/133 (12%)
Query: 498 EPAAQEESLSQAPARAVLQPGASPLPDGESEASRPPRVHGPPTETLPTPRERNLASPSP- 556
E ++ ES S+ A GAS P+ E S P + +ET E NL S
Sbjct: 1978 EVSSVPESSSETSAYPEAGFGASAAPEASREDSGSPDL----SETTSAFHEANLERSSGL 2033
Query: 557 ----STLVEAREVGEATGGPELSGVPRGESEETGSSEGAPSLLPATRAPEGTRELEAPSE 612
STL + GEA+ PE+SG S+ + G PS AT G R S
Sbjct: 2034 GVSGSTLTF--QEGEASAAPEVSGESTTTSDVGTEAPGLPS---ATPTASGDR--TEISG 2086
Query: 613 DNSGRTAPAGTSV 625
D SG T+ G +
Sbjct: 2087 DLSGHTSQLGVVI 2099
Score = 33.9 bits (76), Expect = 0.50
Identities = 41/155 (26%), Positives = 57/155 (36%), Gaps = 17/155 (10%)
Query: 508 QAPARAVLQPGASPLPDGESEASRPPR--------VHGPPTETLPTPRERNLASPSPSTL 559
QAP + L G S G S PP G PT +L + + S ++
Sbjct: 1504 QAPETSGLPSGFSGEYSGVDLGSGPPSGLPDFSGLPSGFPTVSLVDSTLVEVVTASTASE 1563
Query: 560 VEAREVGEATGGPELSGVPRGESEETGSSEGAPSLLPATRAPEGTRELEAPSEDNSGRTA 619
+E R +G E+SG+P E + +G + G PS + G S D SG
Sbjct: 1564 LEGRGTIGISGAGEISGLPSSELDISGRASGLPSGTELSGQASG-------SPDVSGE-I 1615
Query: 620 PAGTSVQAQPV-LPTDSASRGGVAVVPASGNSAQG 653
P V QP P S GV + + G
Sbjct: 1616 PGLFGVSGQPSGFPDTSGETSGVTELSGLSSGQPG 1650
Score = 32.3 bits (72), Expect = 1.5
Identities = 49/151 (32%), Positives = 67/151 (44%), Gaps = 25/151 (16%)
Query: 485 ELSSPGPE--ASLPT----EPAAQE-ESLSQAPARAVLQPGA------SPLPDGESEASR 531
E ++PG E + LP+ E AA E +S P+ VL+ A S LP GE +
Sbjct: 1097 ETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETA 1156
Query: 532 PPRVHGPPTETLPTPRERNLASPSPSTL--VEAREVGE--ATGGPELSGVPRGESEETGS 587
P V LP+ A+P + + + EV E A G ++SG+P GE ET
Sbjct: 1157 APGVED--ISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLET-- 1212
Query: 588 SEGAPSLLPATRAPEG-TRELEAPS-EDNSG 616
AP + + P G E AP ED SG
Sbjct: 1213 --AAPGVEDISGLPSGEVLETAAPGVEDISG 1241
Score = 32.0 bits (71), Expect = 1.9
Identities = 46/151 (30%), Positives = 65/151 (43%), Gaps = 25/151 (16%)
Query: 485 ELSSPGPE--ASLPTEPAAQE-----ESLSQAPARAVLQPGA------SPLPDGESEASR 531
E ++PG E + LP+ + E +S P+ VL+ A S LP GE +
Sbjct: 1059 ETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETA 1118
Query: 532 PPRVHGPPTETLPTPRERNLASPSPSTL--VEAREVGE--ATGGPELSGVPRGESEETGS 587
P V LP+ A+P + + + EV E A G ++SG+P GE ET
Sbjct: 1119 APGVED--ISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLET-- 1174
Query: 588 SEGAPSLLPATRAPEG-TRELEAPS-EDNSG 616
AP + + P G E AP ED SG
Sbjct: 1175 --AAPGVEDISGLPSGEVLETAAPGVEDISG 1203
Score = 32.0 bits (71), Expect = 1.9
Identities = 34/114 (29%), Positives = 48/114 (42%), Gaps = 11/114 (9%)
Query: 504 ESLSQAPARAVLQPGASPLPDGESEASRPPRVHGPPTETLPTPRERNLASPSPSTLVEAR 563
E +S P+ V++ AS + D S G ET + E PS ++E
Sbjct: 1371 EDISGLPSGEVVETSASGIEDVSELPS------GEGLETSASGVEDLSRLPSGEEVLEI- 1423
Query: 564 EVGEATGGPELSGVPRG-ESEETGSSEGAPSLLPATRAPEGTRELEAPSEDNSG 616
A+G +LSG+P G E ET +SE L EG + +ED SG
Sbjct: 1424 ---SASGFGDLSGLPSGGEGLETSASEVGTDLSGLPSGREGLETSASGAEDLSG 1474
Score = 31.6 bits (70), Expect = 2.5
Identities = 47/151 (31%), Positives = 66/151 (43%), Gaps = 25/151 (16%)
Query: 485 ELSSPGPE--ASLPTEPAAQE-----ESLSQAPARAVLQ---PGA---SPLPDGESEASR 531
E ++PG E + LP+ + E +S P+ VL+ PG S LP GE +
Sbjct: 1021 ETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETT 1080
Query: 532 PPRVHGPPTETLPTPRERNLASPSPSTL--VEAREVGE--ATGGPELSGVPRGESEETGS 587
P V LP+ A+P + + + EV E A G ++SG+P GE ET
Sbjct: 1081 APGVED--ISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLET-- 1136
Query: 588 SEGAPSLLPATRAPEG-TRELEAPS-EDNSG 616
AP + + P G E AP ED SG
Sbjct: 1137 --AAPGVEDISGLPSGEVLETAAPGVEDISG 1165
Score = 31.6 bits (70), Expect = 2.5
Identities = 50/162 (30%), Positives = 72/162 (44%), Gaps = 28/162 (17%)
Query: 485 ELSSPGPE--ASLPT----EPAAQE-ESLSQAPARAVLQPGA------SPLPDGESEASR 531
E ++PG E + LP+ E AA E +S P+ VL+ A S LP GE +
Sbjct: 1230 ETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETT 1289
Query: 532 PPRVHGPPTETLPTPRERNLASPSPSTL--VEAREVGEAT--GGPELSGVPRGESEETGS 587
P V LP+ +P + + + EV E T G E+SG+P GE ET +
Sbjct: 1290 APGVE--EISGLPSGEVLETTAPGVDEISGLPSGEVLETTAPGVEEISGLPSGEVLETST 1347
Query: 588 SEGAPSLLPATRAPEGTRELE---APSEDNSGRTAPAGTSVQ 626
S ++ + P G LE + ED SG P+G V+
Sbjct: 1348 S----AVGDLSGLPSGGEVLEISVSGVEDISG--LPSGEVVE 1383
Score = 31.6 bits (70), Expect = 2.5
Identities = 50/181 (27%), Positives = 74/181 (40%), Gaps = 28/181 (15%)
Query: 489 PGPEASLPTEPAAQEESLSQAPARAVLQ---PGA---SPLPDGESEASRPPRVHG----P 538
P E T P +E +S P+ VL+ PG S LP GE + P V P
Sbjct: 1281 PSGEVLETTAPGVEE--ISGLPSGEVLETTAPGVDEISGLPSGEVLETTAPGVEEISGLP 1338
Query: 539 PTETLPTPRERNLASPSPSTLVEAREVGE--ATGGPELSGVPRGESEETGSSEGAPSLLP 596
E L T A S L EV E +G ++SG+P GE ET +S +
Sbjct: 1339 SGEVLETSTS---AVGDLSGLPSGGEVLEISVSGVEDISGLPSGEVVETSAS----GIED 1391
Query: 597 ATRAPEGT-RELEAPSEDNSGRTAPAGTSVQAQPVLPTDSASRGGVAVVPASGNSAQGST 655
+ P G E A ++ R P+G + VL ++ G ++ +P+ G + S
Sbjct: 1392 VSELPSGEGLETSASGVEDLSR-LPSG-----EEVLEISASGFGDLSGLPSGGEGLETSA 1445
Query: 656 A 656
+
Sbjct: 1446 S 1446
Score = 30.8 bits (68), Expect = 4.2
Identities = 46/151 (30%), Positives = 65/151 (43%), Gaps = 25/151 (16%)
Query: 485 ELSSPGPE--ASLPTEPAAQE-----ESLSQAPARAVLQ---PGA---SPLPDGESEASR 531
E ++PG E + LP+ + E +S P+ VL+ PG S LP GE +
Sbjct: 983 ETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETT 1042
Query: 532 PPRVHGPPTETLPTPRERNLASPSPSTL--VEAREVGEAT--GGPELSGVPRGESEETGS 587
P V LP+ +P + + + EV E T G ++SG+P GE ET
Sbjct: 1043 APGVED--ISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLET-- 1098
Query: 588 SEGAPSLLPATRAPEG-TRELEAPS-EDNSG 616
AP + + P G E AP ED SG
Sbjct: 1099 --AAPGVEDISGLPSGEVLETAAPGVEDISG 1127
Score = 29.6 bits (65), Expect = 9.4
Identities = 35/126 (27%), Positives = 51/126 (40%), Gaps = 15/126 (11%)
Query: 491 PEASLPTEPAAQEESLSQAPARAVLQPGASP------LPDGES----EASRPPRVHGPPT 540
P + A+ E +S+ P+ L+ AS LP GE AS + G P+
Sbjct: 1377 PSGEVVETSASGIEDVSELPSGEGLETSASGVEDLSRLPSGEEVLEISASGFGDLSGLPS 1436
Query: 541 ETLPTPRERNLASPSPSTLVEAREVGE--ATGGPELSGVPRGESEETGSSEGAPSLLPAT 598
+ S L RE E A+G +LSG+P G+ + GS+ G L
Sbjct: 1437 GGEGLETSASEVGTDLSGLPSGREGLETSASGAEDLSGLPSGKEDLVGSASGD---LDLG 1493
Query: 599 RAPEGT 604
+ P GT
Sbjct: 1494 KLPSGT 1499
>gi|118600983 chondroitin sulfate proteoglycan 3 [Homo sapiens]
Length = 1321
Score = 332 bits (851), Expect = 7e-91
Identities = 182/447 (40%), Positives = 256/447 (57%), Gaps = 17/447 (3%)
Query: 4 LFLPLLAALVLAQAPAALADVLEGDSSEDRAFRVRIAGDAPLQGVLGGALTIPCHVHYLR 63
L L +L L+ D+ + + +R ++ G +Q L + +PC + L+
Sbjct: 9 LGLLMLQMLLFVAGEQGTQDITD---ASERGLHMQKLGSGSVQAALAELVALPC-LFTLQ 64
Query: 64 PPPSRRAVLGSPRVKWTFL----SRGREAEVLVARGVRVKVNEAYRFRVALPAYPASLTD 119
P PS A +PR+KWT + + ++ +LVA+ V+V ++++ RV+LP+YP +
Sbjct: 65 PRPS--AARDAPRIKWTKVRTASGQRQDLPILVAKDNVVRVAKSWQGRVSLPSYPRRRAN 122
Query: 120 VSLALSELRPNDSGIYRCEVQHGIDDSSDAVEVKVKGVVFLYREGSARYAFSFSGAQEAC 179
+L L LR +DSG+YRC+V GI+D D V ++V GVVF YR RYA +F+ AQEAC
Sbjct: 123 ATLLLGPLRASDSGLYRCQVVRGIEDEQDLVPLEVTGVVFHYRSARDRYALTFAEAQEAC 182
Query: 180 ARIGAHIATPEQLYAAYLGGYEQCDAGWLSDQTVRYPIQTPREACYGDMDGFPGVRNYGV 239
A IA P L AA+ G++ CDAGWLSD+TVRYPI R CYGD PGVR+YG
Sbjct: 183 RLSSAIIAAPRHLQAAFEDGFDNCDAGWLSDRTVRYPITQSRPGCYGDRSSLPGVRSYGR 242
Query: 240 VDPDDLYDVYCYAEDLNGELFLGDPPEKLTLEEARAYCQERGAEIATTGQLYAAWDGGLD 299
+P +LYDVYC+A +L GE+F P +LTL ARA C+ +GA +A+ GQL+ AW GLD
Sbjct: 243 RNPQELYDVYCFARELGGEVFYVGPARRLTLAGARAQCRRQGAALASVGQLHLAWHEGLD 302
Query: 300 HCSPGWLADGSVRYPIVTPSQRCGGGLPGVKTLFLFPNQTGFPNKHSRFNVYCFRDSAQP 359
C PGWLADGSVRYPI TP +RCGG PGV+T++ F N+TGFP+ RF+ YCFR
Sbjct: 303 QCDPGWLADGSVRYPIQTPRRRCGGPAPGVRTVYRFANRTGFPSPAERFDAYCFRAHHPT 362
Query: 360 SAIPEASNPASNPASDGLEAIVTVTETLEELQLPQEATESESRGAIYSIPIMEDGGGGSS 419
S + P+S + L A LE +E + + P++ G +
Sbjct: 363 SQHGDLETPSSGDEGEILSAEGPPVRELEPTLEEEEVVTPD-----FQEPLVSSGEEETL 417
Query: 420 TPEDPAEAPRTLLEFETQSMVP--PTG 444
E+ E+ +TL M+ PTG
Sbjct: 418 ILEEKQESQQTLSPTPGDPMLASWPTG 444
>gi|21361116 versican isoform 1 [Homo sapiens]
Length = 3396
Score = 324 bits (830), Expect = 2e-88
Identities = 176/446 (39%), Positives = 251/446 (56%), Gaps = 24/446 (5%)
Query: 36 RVRIAGDAPLQGVLGGALTIPCHVHYLRPPPSRRAVLGSPRVKWTFLSRGR------EAE 89
+V++ P++G L G +++PCH + P R+KW+ + + E
Sbjct: 23 KVKVGKSPPVRGSLSGKVSLPCHFSTMPTLPPSYNTSEFLRIKWSKIEVDKNGKDLKETT 82
Query: 90 VLVARGVRVKVNEAYRFRVALPAYPASLTDVSLALSELRPNDSGIYRCEVQHGIDDSSDA 149
VLVA+ +K+ + Y+ RV++P +P ++ D SL + +L +D+G+YRC+V +GI+D+ D
Sbjct: 83 VLVAQNGNIKIGQDYKGRVSVPTHPEAVGDASLTVVKLLASDAGLYRCDVMYGIEDTQDT 142
Query: 150 VEVKVKGVVFLYREGSARYAFSFSGAQEACARIGAHIATPEQLYAAYLGGYEQCDAGWLS 209
V + V GVVF YR ++RY +F AQ+AC +GA IATPEQL+AAY G+EQCDAGWL+
Sbjct: 143 VSLTVDGVVFHYRAATSRYTLNFEAAQKACLDVGAVIATPEQLFAAYEDGFEQCDAGWLA 202
Query: 210 DQTVRYPIQTPREACYGDMDGFPGVRNYGVVDPDDLYDVYCYAEDLNGELFLGDPPEKLT 269
DQTVRYPI+ PR CYGD G GVR YG P + YDVYCY + L+G++F P K T
Sbjct: 203 DQTVRYPIRAPRVGCYGDKMGKAGVRTYGFRSPQETYDVYCYVDHLDGDVFHLTVPSKFT 262
Query: 270 LEEARAYCQERGAEIATTGQLYAAWDGGLDHCSPGWLADGSVRYPIVTPSQRCGGGLPGV 329
EEA C+ + A +AT G+L AAW G D C GWL+D SVR+P+ +CGGGL GV
Sbjct: 263 FEEAAKECENQDARLATVGELQAAWRNGFDQCDYGWLSDASVRHPVTVARAQCGGGLLGV 322
Query: 330 KTLFLFPNQTGFPNKHSRFNVYCFR----DSAQPSAIPEASNPASNP----ASDGLEAIV 381
+TL+ F NQTGFP SRF+ YCF+ + S + E ++P+ + SD I+
Sbjct: 323 RTLYRFENQTGFPPPDSRFDAYCFKPKEATTIDLSILAETASPSLSKEPQMVSDRTTPII 382
Query: 382 TVTETLEELQLPQEATESESRGAIYSIPIMEDGGGGSSTPEDPAEAPRTLLEFETQSMVP 441
+ + +LP TE G I S + P+ ++ T L T S
Sbjct: 383 PLVD-----ELPVIPTEFPPVGNIVSFE-----QKATVQPQAITDSLATKLPTPTGSTKK 432
Query: 442 PTGFSEEEGKALEEEEKYEDEEEKEE 467
P + A K + E KEE
Sbjct: 433 PWDMDDYSPSASGPLGKLDISEIKEE 458
>gi|187607300 versican isoform 2 [Homo sapiens]
Length = 655
Score = 322 bits (826), Expect = 5e-88
Identities = 151/325 (46%), Positives = 210/325 (64%), Gaps = 6/325 (1%)
Query: 36 RVRIAGDAPLQGVLGGALTIPCHVHYLRPPPSRRAVLGSPRVKWTFLSRGR------EAE 89
+V++ P++G L G +++PCH + P R+KW+ + + E
Sbjct: 23 KVKVGKSPPVRGSLSGKVSLPCHFSTMPTLPPSYNTSEFLRIKWSKIEVDKNGKDLKETT 82
Query: 90 VLVARGVRVKVNEAYRFRVALPAYPASLTDVSLALSELRPNDSGIYRCEVQHGIDDSSDA 149
VLVA+ +K+ + Y+ RV++P +P ++ D SL + +L +D+G+YRC+V +GI+D+ D
Sbjct: 83 VLVAQNGNIKIGQDYKGRVSVPTHPEAVGDASLTVVKLLASDAGLYRCDVMYGIEDTQDT 142
Query: 150 VEVKVKGVVFLYREGSARYAFSFSGAQEACARIGAHIATPEQLYAAYLGGYEQCDAGWLS 209
V + V GVVF YR ++RY +F AQ+AC +GA IATPEQL+AAY G+EQCDAGWL+
Sbjct: 143 VSLTVDGVVFHYRAATSRYTLNFEAAQKACLDVGAVIATPEQLFAAYEDGFEQCDAGWLA 202
Query: 210 DQTVRYPIQTPREACYGDMDGFPGVRNYGVVDPDDLYDVYCYAEDLNGELFLGDPPEKLT 269
DQTVRYPI+ PR CYGD G GVR YG P + YDVYCY + L+G++F P K T
Sbjct: 203 DQTVRYPIRAPRVGCYGDKMGKAGVRTYGFRSPQETYDVYCYVDHLDGDVFHLTVPSKFT 262
Query: 270 LEEARAYCQERGAEIATTGQLYAAWDGGLDHCSPGWLADGSVRYPIVTPSQRCGGGLPGV 329
EEA C+ + A +AT G+L AAW G D C GWL+D SVR+P+ +CGGGL GV
Sbjct: 263 FEEAAKECENQDARLATVGELQAAWRNGFDQCDYGWLSDASVRHPVTVARAQCGGGLLGV 322
Query: 330 KTLFLFPNQTGFPNKHSRFNVYCFR 354
+TL+ F NQTGFP SRF+ YCF+
Sbjct: 323 RTLYRFENQTGFPPPDSRFDAYCFK 347
>gi|30102948 hyaluronan and proteoglycan link protein 3 [Homo
sapiens]
Length = 360
Score = 233 bits (593), Expect = 6e-61
Identities = 141/310 (45%), Positives = 181/310 (58%), Gaps = 19/310 (6%)
Query: 50 GGALTIPCHVHYLRPPPSRRAVLGSPRVKWTFLSRGR--EAEVLVARGVRVKVNEAYRFR 107
G ++ +PC Y S R V RVKW LS E +VLVA G+R + Y+ R
Sbjct: 63 GASVILPCRYRYEPALVSPRRV----RVKWWKLSENGAPEKDVLVAIGLRHRSFGDYQGR 118
Query: 108 VALPAYPASLTDVSLALSELRPNDSGIYRCEVQHGIDDSSDAVEVKVKGVVFLYREGSAR 167
V L DVSL + +LR D G YRCEV G++D S VE++++GVVF Y+ + R
Sbjct: 119 VHLRQDKEH--DVSLEIQDLRLEDYGRYRCEVIDGLEDESGLVELELRGVVFPYQSPNGR 176
Query: 168 YAFSFSGAQEACARIGAHIATPEQLYAAYLGGYEQCDAGWLSDQTVRYPIQTPREACYGD 227
Y F+F Q+ CA A +A+ EQL+ A+ G + C+AGWL D TV+YPI PR+ C G
Sbjct: 177 YQFNFHEGQQVCAEQAAVVASFEQLFRAWEEGLDWCNAGWLQDATVQYPIMLPRQPC-GG 235
Query: 228 MDGFPGVRNYGVVDPD-DLYDVYCYAEDLNGELFLGDPPEKLTLEEARAYCQERGAEIAT 286
PGVR+YG YDV+C+A L G ++ + PEKLTL EAR CQE A IA
Sbjct: 236 PGLAPGVRSYGPRHRRLHRYDVFCFATALKGRVYYLEHPEKLTLTEAREACQEDDATIAK 295
Query: 287 TGQLYAAWD-GGLDHCSPGWLADGSVRYPIVTPSQRCGGGLPGVKTLFLFPNQTGFPNKH 345
GQL+AAW GLD C GWLADGSVRYP+V P CG PGV++ GFP+
Sbjct: 296 VGQLFAAWKFHGLDRCDAGWLADGSVRYPVVHPHPNCGPPEPGVRSF-------GFPDPQ 348
Query: 346 SR-FNVYCFR 354
SR + VYC+R
Sbjct: 349 SRLYGVYCYR 358
>gi|4503053 hyaluronan and proteoglycan link protein 1 [Homo
sapiens]
Length = 354
Score = 224 bits (572), Expect = 2e-58
Identities = 132/310 (42%), Positives = 178/310 (57%), Gaps = 17/310 (5%)
Query: 50 GGALTIPCHVHYLRPPPSRRAVLGSPRVKWTFLSRG--REAEVLVARGVRVKVNEAYRFR 107
GG +T+PC + R P + + + R+KWT L+ +E +V V+ G K Y+ R
Sbjct: 54 GGNVTLPCK--FYRDPTAFGSGIHKIRIKWTKLTSDYLKEVDVFVSMGYHKKTYGGYQGR 111
Query: 108 VALPAYPASLTDVSLALSELRPNDSGIYRCEVQHGIDDSSDAVEVKVKGVVFLYREGSAR 167
V L S +D SL +++L D G Y+CEV G++D + V + ++GVVF Y R
Sbjct: 112 VFLKG--GSDSDASLVITDLTLEDYGRYKCEVIEGLEDDTVVVALDLQGVVFPYFPRLGR 169
Query: 168 YAFSFSGAQEACARIGAHIATPEQLYAAYLGGYEQCDAGWLSDQTVRYPIQTPREACYGD 227
Y +F AQ+AC A IA+ +QLY A+ GG + C+AGWLSD +V+YPI PRE C G
Sbjct: 170 YNLNFHEAQQACLDQDAVIASFDQLYDAWRGGLDWCNAGWLSDGSVQYPITKPREPC-GG 228
Query: 228 MDGFPGVRNYGVVDPD-DLYDVYCYAEDLNGELFLGDPPEKLTLEEARAYCQERGAEIAT 286
+ PGVRNYG D D YDV+C+ + NG + P KLT +EA C GA+IA
Sbjct: 229 QNTVPGVRNYGFWDKDKSRYDVFCFTSNFNGRFYYLIHPTKLTYDEAVQACLNDGAQIAK 288
Query: 287 TGQLYAAWD-GGLDHCSPGWLADGSVRYPIVTPSQRCGGGLPGVKTLFLFPNQTGFPN-K 344
GQ++AAW G D C GWLADGSVRYPI P +RC V+ + GFP+ K
Sbjct: 289 VGQIFAAWKILGYDRCDAGWLADGSVRYPISRPRRRCSPTEAAVRFV-------GFPDKK 341
Query: 345 HSRFNVYCFR 354
H + VYCFR
Sbjct: 342 HKLYGVYCFR 351
>gi|30794472 hyaluronan and proteoglycan link protein 4 [Homo
sapiens]
Length = 402
Score = 209 bits (532), Expect = 7e-54
Identities = 138/374 (36%), Positives = 187/374 (50%), Gaps = 41/374 (10%)
Query: 12 LVLAQAPAA-------LADVLEGDSSEDRAFRVRIAGDAPLQGVL--GGALTIPCHVHYL 62
++L APA + VLEG+S + AP Q V GG + +PC HY
Sbjct: 20 VLLLTAPAGAQRGRKKVVHVLEGESGSV------VVQTAPGQVVSHRGGTIVLPCRYHYE 73
Query: 63 RPPPSRRAVLGSPRVKWT-FLSRGREAEVLVARGVRVKVNEAYRFRVALPAYPASLTDVS 121
V R+KWT + +V VA G + + +YR R L D S
Sbjct: 74 AAAHGHDGV----RLKWTKVVDPLAFTDVFVALGPQHRAFGSYRGRAELQGDGPG--DAS 127
Query: 122 LALSELRPNDSGIYRCEVQHGIDDSSDAVEVKVKGVVFLYREGSARYAFSFSGAQEACAR 181
L L + D G Y CEV + ++D + V++ ++GVVF Y RY +F+ AQ ACA
Sbjct: 128 LVLRNVTLQDYGRYECEVTNELEDDAGMVKLDLEGVVFPYHPRGGRYKLTFAEAQRACAE 187
Query: 182 IGAHIATPEQLYAAYLGGYEQCDAGWLSDQTVRYPIQTPREAC---------YGDMDGFP 232
+A+ EQL+AA+ G + C+AGWL D +V+YP+ PRE C G D
Sbjct: 188 QDGILASAEQLHAAWRDGLDWCNAGWLRDGSVQYPVNRPREPCGGLGGTGSAGGGGDANG 247
Query: 233 GVRNYGV-VDPDDLYDVYCYAEDLNGELFLGDPPEKLTLEEARAYCQERGAEIATTGQLY 291
G+RNYG + ++ YD +C+ +L G +F P + A C RGA +A GQL+
Sbjct: 248 GLRNYGYRHNAEERYDAFCFTSNLPGRVFFLKPLRPVPFSGAARACAARGAAVAKVGQLF 307
Query: 292 AAWD-GGLDHCSPGWLADGSVRYPIVTPSQRCGGGLPGVKTLFLFPNQTGFPNKHSR-FN 349
AAW LD C+ GWLADGS RYPIV P RCGG PGV++L GFP+ R F
Sbjct: 308 AAWKLQLLDRCTAGWLADGSARYPIVNPRARCGGRRPGVRSL-------GFPDATRRLFG 360
Query: 350 VYCFRDSAQPSAIP 363
VYC+R P P
Sbjct: 361 VYCYRAPGAPDPAP 374
>gi|11141887 brain link protein-1 [Homo sapiens]
Length = 340
Score = 204 bits (518), Expect = 3e-52
Identities = 123/313 (39%), Positives = 173/313 (55%), Gaps = 28/313 (8%)
Query: 50 GGALTIPCHVHYLRPPPSRRAVLGSPRVKWTFLSRG--REAEVLVARGVRVKVNEAYRFR 107
G T+PC V PP S +V+W+ + G RE +L+ G+ + R
Sbjct: 50 GATATLPC-VLGTTPP--------SYKVRWSKVEPGELRETLILITNGLHARGYGPLGGR 100
Query: 108 VALPAYPASLTDVSLALSELRPNDSGIYRCEVQHGIDDSSDAVEVKVKGVVFLYREGSAR 167
+ D SL ++ +R D G YRCE+ +GI+D S A+ + ++GVVF Y+ R
Sbjct: 101 ARMRR--GHRLDASLVIAGVRLEDEGRYRCELINGIEDESVALTLSLEGVVFPYQPSRGR 158
Query: 168 YAFSFSGAQEACARIGAHIATPEQLYAAYLGGYEQCDAGWLSDQTVRYPIQTPREACYGD 227
Y F++ A++AC +AT QLY A+ G + C+AGWL + +VRYP+ T R C G
Sbjct: 159 YQFNYYEAKQACEEQDGRLATYSQLYQAWTEGLDWCNAGWLLEGSVRYPVLTARAPCGG- 217
Query: 228 MDGFPGVRNYGVVD-PDDLYDVYCYAEDLNGELFLGDPPEKLTLEEARAYCQERGAEIAT 286
G PG+R+YG D D YD +C+ L G++F P +LTL EA A C+ RGA +A
Sbjct: 218 -RGRPGIRSYGPRDRMRDRYDAFCFTSALAGQVFF--VPGRLTLSEAHAACRRRGAVVAK 274
Query: 287 TGQLYAAWD-GGLDHCSPGWLADGSVRYPIVTPSQRCGG-GLPGVKTLFLFPNQTGFPN- 343
G LYAAW GLD C GWLADGSVR+PI TP RCGG PGV++ GFP
Sbjct: 275 VGHLYAAWKFSGLDQCDGGWLADGSVRFPITTPRPRCGGLPDPGVRSF-------GFPRP 327
Query: 344 KHSRFNVYCFRDS 356
+ + + YC+ ++
Sbjct: 328 QQAAYGTYCYAEN 340
>gi|26051243 tumor necrosis factor, alpha-induced protein 6
precursor [Homo sapiens]
Length = 277
Score = 63.5 bits (153), Expect = 6e-10
Identities = 35/92 (38%), Positives = 48/92 (52%), Gaps = 6/92 (6%)
Query: 267 KLTLEEARAYCQERGAEIATTGQLYAAWDGGLDHCSPGWLADGSVRYPIVTPSQRCGGGL 326
KLT EA+A C+ G +AT QL AA G C+ GW+A G V YPIV P CG G
Sbjct: 48 KLTYAEAKAVCEFEGGHLATYKQLEAARKIGFHVCAAGWMAKGRVGYPIVKPGPNCGFGK 107
Query: 327 PGVKTLFLFPNQTGFPNKHSRFNVYCFRDSAQ 358
G+ + N++ R++ YC+ A+
Sbjct: 108 TGIIDYGIRLNRS------ERWDAYCYNPHAK 133
Score = 57.4 bits (137), Expect = 4e-08
Identities = 31/88 (35%), Positives = 48/88 (54%), Gaps = 4/88 (4%)
Query: 165 SARYAFSFSGAQEACARIGAHIATPEQLYAAYLGGYEQCDAGWLSDQTVRYPIQTPREAC 224
S +Y +++ A+ C G H+AT +QL AA G+ C AGW++ V YPI P C
Sbjct: 44 SGKYKLTYAEAKAVCEFEGGHLATYKQLEAARKIGFHVCAAGWMAKGRVGYPIVKPGPNC 103
Query: 225 YGDMDGFPGVRNYGV-VDPDDLYDVYCY 251
G G+ +YG+ ++ + +D YCY
Sbjct: 104 ---GFGKTGIIDYGIRLNRSERWDAYCY 128
>gi|61743978 stabilin 1 precursor [Homo sapiens]
Length = 2570
Score = 62.4 bits (150), Expect = 1e-09
Identities = 35/90 (38%), Positives = 46/90 (51%), Gaps = 6/90 (6%)
Query: 265 PEKLTLEEARAYCQERGAEIATTGQLYAAWDGGLDHCSPGWLADGSVRYPIVTPSQRCGG 324
P L EA A C+ +GA +A+ QL AA G C GWLA+GS +P+V P CG
Sbjct: 2218 PYGLNFSEAEAACEAQGAVLASFPQLSAAQQLGFHLCLMGWLANGSTAHPVVFPVADCGN 2277
Query: 325 GLPGVKTLFLFPNQTGFPNKHSRFNVYCFR 354
G G+ +L N R++ YCFR
Sbjct: 2278 GRVGIVSL------GARKNLSERWDAYCFR 2301
Score = 47.0 bits (110), Expect = 6e-05
Identities = 30/95 (31%), Positives = 48/95 (50%), Gaps = 4/95 (4%)
Query: 158 VFLYREGSARYAFSFSGAQEACARIGAHIATPEQLYAAYLGGYEQCDAGWLSDQTVRYPI 217
VF + S Y +FS A+ AC GA +A+ QL AA G+ C GWL++ + +P+
Sbjct: 2209 VFHLQATSGPYGLNFSEAEAACEAQGAVLASFPQLSAAQQLGFHLCLMGWLANGSTAHPV 2268
Query: 218 QTPREACYGDMDGFPGVRNYGV-VDPDDLYDVYCY 251
P C +G G+ + G + + +D YC+
Sbjct: 2269 VFPVADC---GNGRVGIVSLGARKNLSERWDAYCF 2300
>gi|61743980 stabilin 2 precursor [Homo sapiens]
Length = 2551
Score = 60.1 bits (144), Expect = 7e-09
Identities = 33/88 (37%), Positives = 43/88 (48%), Gaps = 6/88 (6%)
Query: 267 KLTLEEARAYCQERGAEIATTGQLYAAWDGGLDHCSPGWLADGSVRYPIVTPSQRCGGGL 326
KLT ++AR C A +AT QL A CS GWL G V YP SQ CG G+
Sbjct: 2210 KLTFDKAREACANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGV 2269
Query: 327 PGVKTLFLFPNQTGFPNKHSRFNVYCFR 354
G+ + PNK ++V+C+R
Sbjct: 2270 VGI------VDYGPRPNKSEMWDVFCYR 2291
Score = 57.4 bits (137), Expect = 4e-08
Identities = 36/101 (35%), Positives = 50/101 (49%), Gaps = 5/101 (4%)
Query: 158 VFLYREGSARYAFSFSGAQEACARIGAHIATPEQLYAAYLGGYEQCDAGWLSDQTVRYPI 217
VF R +Y +F A+EACA A +AT QL A Y C AGWL V YP
Sbjct: 2199 VFHLRSPLGQYKLTFDKAREACANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPT 2258
Query: 218 QTPREACYGDMDGFPGVRNYGV-VDPDDLYDVYCY-AEDLN 256
+ C G G+ +YG + +++DV+CY +D+N
Sbjct: 2259 AFASQNC---GSGVVGIVDYGPRPNKSEMWDVFCYRMKDVN 2296
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 59.3 bits (142), Expect = 1e-08
Identities = 67/235 (28%), Positives = 91/235 (38%), Gaps = 24/235 (10%)
Query: 381 VTVTETLEELQLPQEATESESRGAIYSIPIMEDGG------GGSSTPEDPAEAPRTLLEF 434
V V E EE Q+ +E TE E + A E+GG GG + P E
Sbjct: 455 VIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEK 514
Query: 435 ETQSMVPPTGFSEEEGKALEEEEKYEDEEEKEEEEEEEEVEDEALWAWPSELSSP-GPEA 493
E +S V S E K+ E+EE E K E+ + ++EA P E SP EA
Sbjct: 515 EAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEA--KSPPEAKSPEKEEA 572
Query: 494 SLPTEPAAQEESLSQAPARAVLQPGASPLPDG-----ESEASRPPRVHGPPTETLPTPRE 548
P E + E++ S A A P + P+ + EA P P E +P E
Sbjct: 573 KSPAEVKSPEKAKSPAKEEA-KSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAE 631
Query: 549 RNLASPSPSTLVEAREVGEATGGPELSGVPRGESEETGSSEGAPSLLPA-TRAPE 602
+ S E + E P E EE S E A S + A ++PE
Sbjct: 632 VKSPEKAKSPTKEEAKSPEKAKSP--------EKEEAKSPEKAKSPVKAEAKSPE 678
Score = 54.7 bits (130), Expect = 3e-07
Identities = 54/213 (25%), Positives = 85/213 (39%), Gaps = 20/213 (9%)
Query: 423 DPAEAPRTLLEFETQSMVPPTGFSEEEGKALEEEEKYEDEEEKEEEEEEEEVEDEALWAW 482
+ +E ++E +T+ +EEE K +EEE EEE EEEE E E+E
Sbjct: 448 EKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEG--KEEEGGEEEEAEGGEEETKSPP 505
Query: 483 PSELSSPGPEASLPTEPAAQEESLSQAPAR-------AVLQPGASPLPDGESEASRPPRV 535
E +SP EA P + A+ + +++P + V P + P + EA PP
Sbjct: 506 AEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSP-AKEEAKSPPEA 564
Query: 536 HGPPTETLPTPRERNLASPSPSTLVEAREVGEATGGPELSGVPRGESEETGSSEGAPSLL 595
P E +P E + S E + PE + P E ++
Sbjct: 565 KSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKS---------- 614
Query: 596 PATRAPEGTRELEAPSEDNSGRTAPAGTSVQAQ 628
PA E ++P+E S A + T +A+
Sbjct: 615 PAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAK 647
Score = 50.8 bits (120), Expect = 4e-06
Identities = 47/192 (24%), Positives = 71/192 (36%), Gaps = 7/192 (3%)
Query: 448 EEGKALEEEEKYEDEEEKEEEEEEEEV-EDEALWAWPSELSSPGPEASLPTEPAAQEESL 506
EE + EE + E++E KEEE +EEE E+E E SP P E AA E
Sbjct: 462 EETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSP------PAEEAASPEKE 515
Query: 507 SQAPARAVLQPGASPLPDGESEASRPPRVHGPPTETLPTPRERNLASPSPSTLVEAREVG 566
+++P + + A + EA P V P P E + S E +
Sbjct: 516 AKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSP 575
Query: 567 EATGGPELSGVPRGESEETGSSEGAPSLLPATRAPEGTRELEAPSEDNSGRTAPAGTSVQ 626
PE + P E ++ + +P + E EA S +PA
Sbjct: 576 AEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSP 635
Query: 627 AQPVLPTDSASR 638
+ PT ++
Sbjct: 636 EKAKSPTKEEAK 647
Score = 38.9 bits (89), Expect = 0.016
Identities = 40/198 (20%), Positives = 80/198 (40%), Gaps = 12/198 (6%)
Query: 372 PASDGLEAIVTVTETLEELQLPQEATESESRGAIYSIPIMEDGGGGSSTPEDPAEAPRTL 431
P + +++ V E +E+++ + ++E A + P E+ EAP+
Sbjct: 815 PKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAP-ATPKTEEKKDSKKEEAPKKEAPKPK 873
Query: 432 LEFETQSMVPPTGFSEEEGKALEEEEKYEDEEEKEEEEEEEEVEDEALWAWPSELSSPGP 491
+E + + V S+ E K E E+K + ++E + EV+++A +E++ P
Sbjct: 874 VEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEP 933
Query: 492 EASLPTEPAAQEESLSQAPARAVLQPGASPLPDGESEASRPPRVHGPPTETLPTPRERNL 551
+ + EP+ E AP + D + E ++ P P TE ++ L
Sbjct: 934 DDAKAKEPSKPAEKKEAAPEK----------KDTKEEKAKKPE-EKPKTEAKAKEDDKTL 982
Query: 552 ASPSPSTLVEAREVGEAT 569
+ E E +T
Sbjct: 983 SKEPSKPKAEKAEKSSST 1000
Score = 36.2 bits (82), Expect = 0.10
Identities = 55/265 (20%), Positives = 100/265 (37%), Gaps = 15/265 (5%)
Query: 354 RDSAQPSAIPEASNPASNPASDGLEAIVTVTETLE---ELQLPQEA---TESESRGAIYS 407
+ A+ + +A +P A EA V E + E++ P++A T+ E++ +
Sbjct: 593 KSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKA 652
Query: 408 IPIMEDGGGGSSTPEDPAEAPRTLLEFETQSMVPPTGFSEEEGKALEEEEKYEDEEEKEE 467
++ + P +A E + +S V S E+ K+ +EE E+ K
Sbjct: 653 KSPEKEEAKSPEKAKSPVKAEAKSPE-KAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSP 711
Query: 468 EEEEEEVEDEALWAWPSELSSPGPEASLPTEPAAQEESLSQAPARAVLQPGASP-LPDGE 526
+EE + ++A E +P +A P + A+ +++P +A SP
Sbjct: 712 VKEEAKSPEKAKSPVKEEAKTP-EKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPA 770
Query: 527 SEASRPPRVHGPPTETLPTPRERNLASPSPSTLVEAREVGEATGGPELSGVPRGESEETG 586
E +R P P P E + S L E + PE + E +
Sbjct: 771 KEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAK------APEKEIPKKEEVKSPV 824
Query: 587 SSEGAPSLLPATRAPEGTRELEAPS 611
E P + P+ E +AP+
Sbjct: 825 KEEEKPQEVKVKEPPKKAEEEKAPA 849
Score = 35.8 bits (81), Expect = 0.13
Identities = 61/264 (23%), Positives = 93/264 (35%), Gaps = 38/264 (14%)
Query: 363 PEASNPASNPASDGLEAIVTVTET--LEELQLPQEAT---ESESRGAIYSIPIMEDGGGG 417
PEA PA A + ++ EE++ P++A + +++ IP E+
Sbjct: 764 PEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSP 823
Query: 418 SSTPEDPAEA----PRTLLEFETQSMVPPTGFSEEEGKALEEEEKYEDEEEKEEEEEE-- 471
E P E P E E P T E++ EE K E + K EE++E
Sbjct: 824 VKEEEKPQEVKVKEPPKKAEEEKAPATPKT--EEKKDSKKEEAPKKEAPKPKVEEKKEPA 881
Query: 472 -------------EEVEDEALWAWPSELSSPGPEASLPTEPAAQEESLSQAPARAVLQPG 518
EE ED+ P + + E +P + E + P A +
Sbjct: 882 VEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEP 941
Query: 519 ASPLPDGESEASRPPRVHGPPTETLPTPRERNLASPSPSTLVEAREVGEATGGPELSGVP 578
+ P E+ P E P E+ P T +A+E + T E S P
Sbjct: 942 SKPAEKKEA----APEKKDTKEEKAKKPEEK------PKTEAKAKE-DDKTLSKEPS-KP 989
Query: 579 RGESEETGSSEGAPSLLPATRAPE 602
+ E E SS P +A E
Sbjct: 990 KAEKAEKSSSTDQKDSKPPEKATE 1013
>gi|155030232 proline, glutamic acid and leucine rich protein 1 [Homo
sapiens]
Length = 1130
Score = 55.5 bits (132), Expect = 2e-07
Identities = 63/218 (28%), Positives = 85/218 (38%), Gaps = 49/218 (22%)
Query: 408 IPIMEDGGGGSSTPEDPAEAPRTLLEFETQSMVPPTGFSEEEGKALEEEEKYEDEEEK-- 465
+P GGGG P L E T + + EEE + EEEE+ E+EEE+
Sbjct: 861 VPEGTPGGGG----------PPALEEDLTVININSSDEEEEEEEEEEEEEEEEEEEEEDF 910
Query: 466 -----------EEEEEEEEVEDEALWAWPSELSSPGPEASLPTEPAAQE-ESLSQAPARA 513
EEEEEEEE +E EL E E +E E L A
Sbjct: 911 EEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEEEEEEEDEEEEEELEEVEDLEFGTAGG 970
Query: 514 VLQPGASPLPDGESEASRPPRVHGPPTETLPTPRERNLASPSPSTLVEAREVGEATGGPE 573
++ GA P P + PP + PP E+ P+ + P P L+E E G
Sbjct: 971 EVEEGAPPPP------TLPPAL--PPPES--PPKVQPEPEPEPGLLLEVEEPG------- 1013
Query: 574 LSGVPRGESEETGSSEGAPSLLPATRAPEGTRELEAPS 611
+EE ++ AP+L P +G E E S
Sbjct: 1014 --------TEEERGADTAPTLAPEALPSQGEVEREGES 1043
Score = 30.8 bits (68), Expect = 4.2
Identities = 34/137 (24%), Positives = 43/137 (31%), Gaps = 6/137 (4%)
Query: 459 YEDEEEKEEEEEEEEVEDEALWAWPS---ELSSPGPEASLPTEPAAQEESLSQAPARAVL 515
Y+ EE + E E D+++ P L P P + P A + P A
Sbjct: 768 YDKEEASDVEISLESDSDDSVVIVPEGLPPLPPPPPSGATPPPIAPTGPPTASPPVPAKE 827
Query: 516 QPGASPLPDGESEASRPPRVHGPPTETLPTPR---ERNLASPSPSTLVEAREVGEATGGP 572
+P P G PP P TLP P+ E P L E V
Sbjct: 828 EPEELPAAPGPLPPPPPPPPPVPGPVTLPPPQLVPEGTPGGGGPPALEEDLTVININSSD 887
Query: 573 ELSGVPRGESEETGSSE 589
E E EE E
Sbjct: 888 EEEEEEEEEEEEEEEEE 904
Score = 30.8 bits (68), Expect = 4.2
Identities = 35/127 (27%), Positives = 51/127 (40%), Gaps = 22/127 (17%)
Query: 390 LQLPQEATESESRGAIYSIPIMEDG----GGGSSTPEDPAEAPRTLLEFETQSMVPPTGF 445
L++ + TE E RGA + + + G E PA P E + PPT
Sbjct: 1007 LEVEEPGTEEE-RGADTAPTLAPEALPSQGEVEREGESPAAGPPPQELVEEEPSAPPTLL 1065
Query: 446 SEEEGKALEE---------EEKYEDEEEKEEEEEEEEVEDEALWA----WPSELSSPGPE 492
EE ++ EE+ E E E E +E+E+ + A+ A P + P P
Sbjct: 1066 EEETEDGSDKVQPPPETPAEEEMETETEAEALQEKEQDDTAAMLADFIDCPPDDEKPPP- 1124
Query: 493 ASLPTEP 499
PTEP
Sbjct: 1125 ---PTEP 1128
>gi|119220598 apolipoprotein B48 receptor [Homo sapiens]
Length = 1088
Score = 53.9 bits (128), Expect = 5e-07
Identities = 66/269 (24%), Positives = 93/269 (34%), Gaps = 50/269 (18%)
Query: 412 EDGGGGSSTPEDPAEAPRTLLEFETQSMVPPTGFSEEEGKALEEEEKYEDEEEKEE---- 467
+D G G + + P LE +S + G+A E +E +E E +EE
Sbjct: 116 QDSGAGETAKAARCQEPSAHLEARKKSKAGSGACQDRSGQAQERQESHEQEVNREERLRS 175
Query: 468 ---EEEEEEVE---------DEALWAWPSE----LSSPGPEASLPTEPAAQEESLSQAPA 511
EEEEEEV E+ W W E + GP+A+ + E+ + +A A
Sbjct: 176 WEQEEEEEEVRAREPGMARGAESEWTWHGETEGKAGAVGPKAA--GDNREMEQGVREADA 233
Query: 512 RAVLQPGASPLPDGES--------EASRPPRVHGPPTETLPTPRERNLASPSPSTLVEAR 563
+PGA GE E++R GP E P + + + R
Sbjct: 234 GETEEPGAEGAGKGEEVVVVEKACESTRAWGTWGPGAE----PEDWGILGREEARTTPGR 289
Query: 564 EVGEA-TGGPELSGVPRGESEETGSSEGAPSLLPATRAPEGTRELEAPSEDNSGRTAPAG 622
E A G E + GE ET S G E E S TA G
Sbjct: 290 EEARAILDGEEARTISGGEEAETAS---------------GGEEAETASGGEEAGTASGG 334
Query: 623 TSVQAQPVLPTDSASRGGVAVVPASGNSA 651
+AS G A + G+ A
Sbjct: 335 EEAGIASGGEAGTASGGEEAGTASGGDEA 363
Score = 29.6 bits (65), Expect = 9.4
Identities = 55/231 (23%), Positives = 77/231 (33%), Gaps = 46/231 (19%)
Query: 354 RDSAQPSAIPEAS---NPASNPAS--DGLEAIVTVTETLEELQLPQEAT----ESESRGA 404
R A+ SA E S +PA + + +G+ A+V LE+ L +E E E R
Sbjct: 831 RVEAEESAGAEDSCGLDPAGSQTARAEGMGAMVEAGGLLEKWTLLEEEAVGWQEREQR-- 888
Query: 405 IYSIPIMEDGGGGSSTPEDPAEAPRTLLEFETQSMVPPTGFSEEEGKALEEEEKYEDEEE 464
ED G EAPR LL+ E G G+ E +E + E
Sbjct: 889 -------EDSEGRCGDYHPEGEAPR-LLDAE--------GLMVTGGRRAEAKETEPESLE 932
Query: 465 KEEEEEEEEVEDEALWAWPSELSSPGPEASLPTEPAAQEESLSQAPARAVLQPGASPLP- 523
+EE+ A P + ++ + S S+AP L + P
Sbjct: 933 HVRGQEEQPTHQAPAEAAPESVGEAETAEAMGSARGGAANSWSEAPLPGSLLDVSVPRSR 992
Query: 524 -----DGESEASRP-------------PRVHGPPTETLPTPRERNLASPSP 556
SRP P PP E L P +R L P
Sbjct: 993 VHLSRSSSQRRSRPSFRRTPAWEQQEEPPAPNPPEEELSAPEQRPLQLEEP 1043
>gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo
sapiens]
Length = 2715
Score = 53.5 bits (127), Expect = 6e-07
Identities = 56/189 (29%), Positives = 76/189 (40%), Gaps = 41/189 (21%)
Query: 454 EEEEKYEDEEEKEEEEEEEEVEDEALWAWPSELSSPGPEASLPTEPAAQEESLSQAPARA 513
++E+K +DEEE+++EEEE++ E E E + E PAA++E ++ P
Sbjct: 356 KQEQKLDDEEEEKKEEEEKDKEGE-----EKEERAVAEEMM----PAAEKEE-AKLPPPP 405
Query: 514 VLQPGASPLP--DGESEASRPPRVHGPPTETLPTPRERNLASPSPSTLVEAREVGEATGG 571
+ P SP P S + PP PP P P L SP P E +E
Sbjct: 406 LTPPAPSPPPPLPPPSTSPPPPLCPPPPPPVSPPP----LPSPPPPPAQEEQEESPPPVV 461
Query: 572 PELSGVPRGESEETGSSEGAPSLLPATRAPEGTRELEAPSEDNSGRTAPAGTSVQAQPVL 631
P RG P L P+ RA E + R P GTS P
Sbjct: 462 PATCSRKRGR----------PPLTPSQRA-----------EREAARAGPEGTS----PPT 496
Query: 632 PTDSASRGG 640
PT S + GG
Sbjct: 497 PTPSTATGG 505
>gi|7657465 podocalyxin-like 2 [Homo sapiens]
Length = 605
Score = 52.8 bits (125), Expect = 1e-06
Identities = 71/247 (28%), Positives = 106/247 (42%), Gaps = 43/247 (17%)
Query: 411 MEDGGGGSSTPEDPAEAPRTLLEFETQSMVPPTGFSEEEGKALEEEEKYEDEEEKEEEEE 470
+ED P P+ P+ L E +PP EEE + EEEE+ ++E EK+EEEE
Sbjct: 130 IEDTSQAQELPNLPSPLPKMNL-VEPPWHMPPR---EEEEEEEEEEEREKEEVEKQEEEE 185
Query: 471 EEEV------EDEAL-----WAWPSELSSPGPEASLPTEPAAQEESLSQAPARAVLQPGA 519
EEE+ ++EA ++ S +PG S E+S QA +
Sbjct: 186 EEELLPVNGSQEEAKPQVRDFSLTSSSQTPGATKS------RHEDSGDQASSGV------ 233
Query: 520 SPLPDGESEASRPPRVHGPP-TETLPTPRERNLAS-PSPSTLVEAREVGEATGGPELSG- 576
E E+S P + P T T TP +++ S + +T++ A +G P+ +
Sbjct: 234 ------EVESSMGPSLLLPSVTPTTVTPGDQDSTSQEAEATVLPAAGLGVEFEAPQEASE 287
Query: 577 -VPRGESEETGSSEGAPSL--LPATRAPEGTRELEAPSEDNSG-RTAPAGTSVQAQPVLP 632
G + +G E P+L P T AP G E P ED G RT+ + L
Sbjct: 288 EATAGAAGLSGQHEEVPALPSFPQTTAPSGA---EHPDEDPLGSRTSASSPLAPGDMELT 344
Query: 633 TDSASRG 639
SA+ G
Sbjct: 345 PSSATLG 351
>gi|38201621 eukaryotic translation initiation factor 4 gamma, 1
isoform 1 [Homo sapiens]
Length = 1599
Score = 52.0 bits (123), Expect = 2e-06
Identities = 69/254 (27%), Positives = 97/254 (38%), Gaps = 32/254 (12%)
Query: 357 AQPSAIPEASNPASNPASDGLEAIVTVT-ETLEELQLPQEATESESRGAIYSIPIMEDGG 415
+ PS P S P P S+ A++++ +T+ +Q+ E S PI + G
Sbjct: 260 SSPSPTPSPS-PVLEPGSEPNLAVLSIPGDTMTTIQMSVEE----------STPISRETG 308
Query: 416 GGSSTPEDPAEAPRTLLEFET--QSMVPPTGFSEEEGKA-----LEEEEKYEDEEEKEEE 468
+P +LE E VP + FS +A E +E E
Sbjct: 309 EPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSE 368
Query: 469 EEEEEVEDEALWAWPSELSSPGPEASLPTEPAAQ-EESLSQAPARAVLQPGASPLPDGES 527
+ E EVE A P S P +P P AQ EE L+ AP+ + SP+ + E
Sbjct: 369 DLEPEVESSPELAPPPACPSESP---VPIAPTAQPEELLNGAPSPPAVD--LSPVSEPEE 423
Query: 528 EASRPPRVHGPPTETLPTPRERNLASPSPSTLVEAREVGEATGGPELSGVPRGESEETGS 587
+A PPT TP A+ SP+ E E E G GE+ E S
Sbjct: 424 QAKEVTASMAPPTIPSATPATAPSAT-SPAQEEEMEEEEEEEEGEA------GEAGEAES 476
Query: 588 SEGAPSLLPATRAP 601
+G LLP P
Sbjct: 477 EKGGEELLPPESTP 490
Score = 43.9 bits (102), Expect = 5e-04
Identities = 70/248 (28%), Positives = 94/248 (37%), Gaps = 21/248 (8%)
Query: 353 FRDSAQPSAIPEASNPASNPASDGL---EAIVTVTETLEELQLPQEATESESRGAIYSIP 409
F S + P AS+ +G+ E + E+ EL P A SES I
Sbjct: 340 FSSSPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVESSPELA-PPPACPSESPVPIAPTA 398
Query: 410 IMEDGGGGSSTPE----DPAEAPRTLLEFETQSMVPPTGFSEEEGKALEEEEKYEDEEEK 465
E+ G+ +P P P + T SM PPT S A ++EE +
Sbjct: 399 QPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEME 458
Query: 466 EEEEEEEEVEDEALWAWPSELSSPGPEASLPTEPAAQEESLSQAPARAVLQPGASPLPDG 525
EEEEEEE EA S G E LP E +LSQ A A +P
Sbjct: 459 EEEEEEEGEAGEA----GEAESEKGGEELLPPESTPIPANLSQNLEAAAATQVAVSVPKR 514
Query: 526 ESEASRPPRVHGPPTETLPTPRERNLASPSPSTLVEAREVGEATGGPEL--SGVP--RGE 581
+ + + L +E N A P VE + + GPE SGVP E
Sbjct: 515 RRKIKELNKKEA-VGDLLDAFKEANPAVPE----VENQPPAGSNPGPESEGSGVPPRPEE 569
Query: 582 SEETGSSE 589
++ET S+
Sbjct: 570 ADETWDSK 577
Score = 36.6 bits (83), Expect = 0.077
Identities = 38/168 (22%), Positives = 59/168 (35%), Gaps = 28/168 (16%)
Query: 486 LSSPGPEASLPTEPAAQEESLSQAPARAVLQPGASPLPDGESEASRPPRVHGP------- 538
LS P PE+ + P L+ G P D E E P + P
Sbjct: 331 LSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSES 390
Query: 539 PTETLPTPRERNLASPSPS-TLVEAREVGEATGGPELSGVPRGESEETGSS-------EG 590
P PT + L + +PS V+ V E P +++E +S
Sbjct: 391 PVPIAPTAQPEELLNGAPSPPAVDLSPVSE----------PEEQAKEVTASMAPPTIPSA 440
Query: 591 APSLLPATRAPEGTRELEAPSEDNSGRTAPAGTSVQ---AQPVLPTDS 635
P+ P+ +P E+E E+ G AG + + +LP +S
Sbjct: 441 TPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELLPPES 488
>gi|38201627 eukaryotic translation initiation factor 4 gamma, 1
isoform 2 [Homo sapiens]
Length = 1512
Score = 52.0 bits (123), Expect = 2e-06
Identities = 69/254 (27%), Positives = 97/254 (38%), Gaps = 32/254 (12%)
Query: 357 AQPSAIPEASNPASNPASDGLEAIVTVT-ETLEELQLPQEATESESRGAIYSIPIMEDGG 415
+ PS P S P P S+ A++++ +T+ +Q+ E S PI + G
Sbjct: 173 SSPSPTPSPS-PVLEPGSEPNLAVLSIPGDTMTTIQMSVEE----------STPISRETG 221
Query: 416 GGSSTPEDPAEAPRTLLEFET--QSMVPPTGFSEEEGKA-----LEEEEKYEDEEEKEEE 468
+P +LE E VP + FS +A E +E E
Sbjct: 222 EPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSE 281
Query: 469 EEEEEVEDEALWAWPSELSSPGPEASLPTEPAAQ-EESLSQAPARAVLQPGASPLPDGES 527
+ E EVE A P S P +P P AQ EE L+ AP+ + SP+ + E
Sbjct: 282 DLEPEVESSPELAPPPACPSESP---VPIAPTAQPEELLNGAPSPPAVD--LSPVSEPEE 336
Query: 528 EASRPPRVHGPPTETLPTPRERNLASPSPSTLVEAREVGEATGGPELSGVPRGESEETGS 587
+A PPT TP A+ SP+ E E E G GE+ E S
Sbjct: 337 QAKEVTASMAPPTIPSATPATAPSAT-SPAQEEEMEEEEEEEEGEA------GEAGEAES 389
Query: 588 SEGAPSLLPATRAP 601
+G LLP P
Sbjct: 390 EKGGEELLPPESTP 403
Score = 43.9 bits (102), Expect = 5e-04
Identities = 70/248 (28%), Positives = 94/248 (37%), Gaps = 21/248 (8%)
Query: 353 FRDSAQPSAIPEASNPASNPASDGL---EAIVTVTETLEELQLPQEATESESRGAIYSIP 409
F S + P AS+ +G+ E + E+ EL P A SES I
Sbjct: 253 FSSSPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVESSPELA-PPPACPSESPVPIAPTA 311
Query: 410 IMEDGGGGSSTPE----DPAEAPRTLLEFETQSMVPPTGFSEEEGKALEEEEKYEDEEEK 465
E+ G+ +P P P + T SM PPT S A ++EE +
Sbjct: 312 QPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEME 371
Query: 466 EEEEEEEEVEDEALWAWPSELSSPGPEASLPTEPAAQEESLSQAPARAVLQPGASPLPDG 525
EEEEEEE EA S G E LP E +LSQ A A +P
Sbjct: 372 EEEEEEEGEAGEA----GEAESEKGGEELLPPESTPIPANLSQNLEAAAATQVAVSVPKR 427
Query: 526 ESEASRPPRVHGPPTETLPTPRERNLASPSPSTLVEAREVGEATGGPEL--SGVP--RGE 581
+ + + L +E N A P VE + + GPE SGVP E
Sbjct: 428 RRKIKELNKKEA-VGDLLDAFKEANPAVPE----VENQPPAGSNPGPESEGSGVPPRPEE 482
Query: 582 SEETGSSE 589
++ET S+
Sbjct: 483 ADETWDSK 490
Score = 36.6 bits (83), Expect = 0.077
Identities = 38/168 (22%), Positives = 59/168 (35%), Gaps = 28/168 (16%)
Query: 486 LSSPGPEASLPTEPAAQEESLSQAPARAVLQPGASPLPDGESEASRPPRVHGP------- 538
LS P PE+ + P L+ G P D E E P + P
Sbjct: 244 LSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSES 303
Query: 539 PTETLPTPRERNLASPSPS-TLVEAREVGEATGGPELSGVPRGESEETGSS-------EG 590
P PT + L + +PS V+ V E P +++E +S
Sbjct: 304 PVPIAPTAQPEELLNGAPSPPAVDLSPVSE----------PEEQAKEVTASMAPPTIPSA 353
Query: 591 APSLLPATRAPEGTRELEAPSEDNSGRTAPAGTSVQ---AQPVLPTDS 635
P+ P+ +P E+E E+ G AG + + +LP +S
Sbjct: 354 TPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELLPPES 401
>gi|38201625 eukaryotic translation initiation factor 4 gamma, 1
isoform 3 [Homo sapiens]
Length = 1435
Score = 52.0 bits (123), Expect = 2e-06
Identities = 69/254 (27%), Positives = 97/254 (38%), Gaps = 32/254 (12%)
Query: 357 AQPSAIPEASNPASNPASDGLEAIVTVT-ETLEELQLPQEATESESRGAIYSIPIMEDGG 415
+ PS P S P P S+ A++++ +T+ +Q+ E S PI + G
Sbjct: 96 SSPSPTPSPS-PVLEPGSEPNLAVLSIPGDTMTTIQMSVEE----------STPISRETG 144
Query: 416 GGSSTPEDPAEAPRTLLEFET--QSMVPPTGFSEEEGKA-----LEEEEKYEDEEEKEEE 468
+P +LE E VP + FS +A E +E E
Sbjct: 145 EPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSE 204
Query: 469 EEEEEVEDEALWAWPSELSSPGPEASLPTEPAAQ-EESLSQAPARAVLQPGASPLPDGES 527
+ E EVE A P S P +P P AQ EE L+ AP+ + SP+ + E
Sbjct: 205 DLEPEVESSPELAPPPACPSESP---VPIAPTAQPEELLNGAPSPPAVD--LSPVSEPEE 259
Query: 528 EASRPPRVHGPPTETLPTPRERNLASPSPSTLVEAREVGEATGGPELSGVPRGESEETGS 587
+A PPT TP A+ SP+ E E E G GE+ E S
Sbjct: 260 QAKEVTASMAPPTIPSATPATAPSAT-SPAQEEEMEEEEEEEEGEA------GEAGEAES 312
Query: 588 SEGAPSLLPATRAP 601
+G LLP P
Sbjct: 313 EKGGEELLPPESTP 326
Score = 43.9 bits (102), Expect = 5e-04
Identities = 70/248 (28%), Positives = 94/248 (37%), Gaps = 21/248 (8%)
Query: 353 FRDSAQPSAIPEASNPASNPASDGL---EAIVTVTETLEELQLPQEATESESRGAIYSIP 409
F S + P AS+ +G+ E + E+ EL P A SES I
Sbjct: 176 FSSSPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVESSPELA-PPPACPSESPVPIAPTA 234
Query: 410 IMEDGGGGSSTPE----DPAEAPRTLLEFETQSMVPPTGFSEEEGKALEEEEKYEDEEEK 465
E+ G+ +P P P + T SM PPT S A ++EE +
Sbjct: 235 QPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEME 294
Query: 466 EEEEEEEEVEDEALWAWPSELSSPGPEASLPTEPAAQEESLSQAPARAVLQPGASPLPDG 525
EEEEEEE EA S G E LP E +LSQ A A +P
Sbjct: 295 EEEEEEEGEAGEA----GEAESEKGGEELLPPESTPIPANLSQNLEAAAATQVAVSVPKR 350
Query: 526 ESEASRPPRVHGPPTETLPTPRERNLASPSPSTLVEAREVGEATGGPEL--SGVP--RGE 581
+ + + L +E N A P VE + + GPE SGVP E
Sbjct: 351 RRKIKELNKKEA-VGDLLDAFKEANPAVPE----VENQPPAGSNPGPESEGSGVPPRPEE 405
Query: 582 SEETGSSE 589
++ET S+
Sbjct: 406 ADETWDSK 413
Score = 36.6 bits (83), Expect = 0.077
Identities = 38/168 (22%), Positives = 59/168 (35%), Gaps = 28/168 (16%)
Query: 486 LSSPGPEASLPTEPAAQEESLSQAPARAVLQPGASPLPDGESEASRPPRVHGP------- 538
LS P PE+ + P L+ G P D E E P + P
Sbjct: 167 LSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSES 226
Query: 539 PTETLPTPRERNLASPSPS-TLVEAREVGEATGGPELSGVPRGESEETGSS-------EG 590
P PT + L + +PS V+ V E P +++E +S
Sbjct: 227 PVPIAPTAQPEELLNGAPSPPAVDLSPVSE----------PEEQAKEVTASMAPPTIPSA 276
Query: 591 APSLLPATRAPEGTRELEAPSEDNSGRTAPAGTSVQ---AQPVLPTDS 635
P+ P+ +P E+E E+ G AG + + +LP +S
Sbjct: 277 TPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELLPPES 324
>gi|38201623 eukaryotic translation initiation factor 4 gamma, 1
isoform 1 [Homo sapiens]
Length = 1599
Score = 52.0 bits (123), Expect = 2e-06
Identities = 69/254 (27%), Positives = 97/254 (38%), Gaps = 32/254 (12%)
Query: 357 AQPSAIPEASNPASNPASDGLEAIVTVT-ETLEELQLPQEATESESRGAIYSIPIMEDGG 415
+ PS P S P P S+ A++++ +T+ +Q+ E S PI + G
Sbjct: 260 SSPSPTPSPS-PVLEPGSEPNLAVLSIPGDTMTTIQMSVEE----------STPISRETG 308
Query: 416 GGSSTPEDPAEAPRTLLEFET--QSMVPPTGFSEEEGKA-----LEEEEKYEDEEEKEEE 468
+P +LE E VP + FS +A E +E E
Sbjct: 309 EPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSE 368
Query: 469 EEEEEVEDEALWAWPSELSSPGPEASLPTEPAAQ-EESLSQAPARAVLQPGASPLPDGES 527
+ E EVE A P S P +P P AQ EE L+ AP+ + SP+ + E
Sbjct: 369 DLEPEVESSPELAPPPACPSESP---VPIAPTAQPEELLNGAPSPPAVD--LSPVSEPEE 423
Query: 528 EASRPPRVHGPPTETLPTPRERNLASPSPSTLVEAREVGEATGGPELSGVPRGESEETGS 587
+A PPT TP A+ SP+ E E E G GE+ E S
Sbjct: 424 QAKEVTASMAPPTIPSATPATAPSAT-SPAQEEEMEEEEEEEEGEA------GEAGEAES 476
Query: 588 SEGAPSLLPATRAP 601
+G LLP P
Sbjct: 477 EKGGEELLPPESTP 490
Score = 43.9 bits (102), Expect = 5e-04
Identities = 70/248 (28%), Positives = 94/248 (37%), Gaps = 21/248 (8%)
Query: 353 FRDSAQPSAIPEASNPASNPASDGL---EAIVTVTETLEELQLPQEATESESRGAIYSIP 409
F S + P AS+ +G+ E + E+ EL P A SES I
Sbjct: 340 FSSSPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVESSPELA-PPPACPSESPVPIAPTA 398
Query: 410 IMEDGGGGSSTPE----DPAEAPRTLLEFETQSMVPPTGFSEEEGKALEEEEKYEDEEEK 465
E+ G+ +P P P + T SM PPT S A ++EE +
Sbjct: 399 QPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEME 458
Query: 466 EEEEEEEEVEDEALWAWPSELSSPGPEASLPTEPAAQEESLSQAPARAVLQPGASPLPDG 525
EEEEEEE EA S G E LP E +LSQ A A +P
Sbjct: 459 EEEEEEEGEAGEA----GEAESEKGGEELLPPESTPIPANLSQNLEAAAATQVAVSVPKR 514
Query: 526 ESEASRPPRVHGPPTETLPTPRERNLASPSPSTLVEAREVGEATGGPEL--SGVP--RGE 581
+ + + L +E N A P VE + + GPE SGVP E
Sbjct: 515 RRKIKELNKKEA-VGDLLDAFKEANPAVPE----VENQPPAGSNPGPESEGSGVPPRPEE 569
Query: 582 SEETGSSE 589
++ET S+
Sbjct: 570 ADETWDSK 577
Score = 36.6 bits (83), Expect = 0.077
Identities = 38/168 (22%), Positives = 59/168 (35%), Gaps = 28/168 (16%)
Query: 486 LSSPGPEASLPTEPAAQEESLSQAPARAVLQPGASPLPDGESEASRPPRVHGP------- 538
LS P PE+ + P L+ G P D E E P + P
Sbjct: 331 LSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSES 390
Query: 539 PTETLPTPRERNLASPSPS-TLVEAREVGEATGGPELSGVPRGESEETGSS-------EG 590
P PT + L + +PS V+ V E P +++E +S
Sbjct: 391 PVPIAPTAQPEELLNGAPSPPAVDLSPVSE----------PEEQAKEVTASMAPPTIPSA 440
Query: 591 APSLLPATRAPEGTRELEAPSEDNSGRTAPAGTSVQ---AQPVLPTDS 635
P+ P+ +P E+E E+ G AG + + +LP +S
Sbjct: 441 TPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELLPPES 488
>gi|38201619 eukaryotic translation initiation factor 4 gamma, 1
isoform 4 [Homo sapiens]
Length = 1403
Score = 52.0 bits (123), Expect = 2e-06
Identities = 69/254 (27%), Positives = 97/254 (38%), Gaps = 32/254 (12%)
Query: 357 AQPSAIPEASNPASNPASDGLEAIVTVT-ETLEELQLPQEATESESRGAIYSIPIMEDGG 415
+ PS P S P P S+ A++++ +T+ +Q+ E S PI + G
Sbjct: 64 SSPSPTPSPS-PVLEPGSEPNLAVLSIPGDTMTTIQMSVEE----------STPISRETG 112
Query: 416 GGSSTPEDPAEAPRTLLEFET--QSMVPPTGFSEEEGKA-----LEEEEKYEDEEEKEEE 468
+P +LE E VP + FS +A E +E E
Sbjct: 113 EPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSE 172
Query: 469 EEEEEVEDEALWAWPSELSSPGPEASLPTEPAAQ-EESLSQAPARAVLQPGASPLPDGES 527
+ E EVE A P S P +P P AQ EE L+ AP+ + SP+ + E
Sbjct: 173 DLEPEVESSPELAPPPACPSESP---VPIAPTAQPEELLNGAPSPPAVD--LSPVSEPEE 227
Query: 528 EASRPPRVHGPPTETLPTPRERNLASPSPSTLVEAREVGEATGGPELSGVPRGESEETGS 587
+A PPT TP A+ SP+ E E E G GE+ E S
Sbjct: 228 QAKEVTASMAPPTIPSATPATAPSAT-SPAQEEEMEEEEEEEEGEA------GEAGEAES 280
Query: 588 SEGAPSLLPATRAP 601
+G LLP P
Sbjct: 281 EKGGEELLPPESTP 294
Score = 43.9 bits (102), Expect = 5e-04
Identities = 70/248 (28%), Positives = 94/248 (37%), Gaps = 21/248 (8%)
Query: 353 FRDSAQPSAIPEASNPASNPASDGL---EAIVTVTETLEELQLPQEATESESRGAIYSIP 409
F S + P AS+ +G+ E + E+ EL P A SES I
Sbjct: 144 FSSSPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVESSPELA-PPPACPSESPVPIAPTA 202
Query: 410 IMEDGGGGSSTPE----DPAEAPRTLLEFETQSMVPPTGFSEEEGKALEEEEKYEDEEEK 465
E+ G+ +P P P + T SM PPT S A ++EE +
Sbjct: 203 QPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEME 262
Query: 466 EEEEEEEEVEDEALWAWPSELSSPGPEASLPTEPAAQEESLSQAPARAVLQPGASPLPDG 525
EEEEEEE EA S G E LP E +LSQ A A +P
Sbjct: 263 EEEEEEEGEAGEA----GEAESEKGGEELLPPESTPIPANLSQNLEAAAATQVAVSVPKR 318
Query: 526 ESEASRPPRVHGPPTETLPTPRERNLASPSPSTLVEAREVGEATGGPEL--SGVP--RGE 581
+ + + L +E N A P VE + + GPE SGVP E
Sbjct: 319 RRKIKELNKKEA-VGDLLDAFKEANPAVPE----VENQPPAGSNPGPESEGSGVPPRPEE 373
Query: 582 SEETGSSE 589
++ET S+
Sbjct: 374 ADETWDSK 381
Score = 36.6 bits (83), Expect = 0.077
Identities = 38/168 (22%), Positives = 59/168 (35%), Gaps = 28/168 (16%)
Query: 486 LSSPGPEASLPTEPAAQEESLSQAPARAVLQPGASPLPDGESEASRPPRVHGP------- 538
LS P PE+ + P L+ G P D E E P + P
Sbjct: 135 LSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSES 194
Query: 539 PTETLPTPRERNLASPSPS-TLVEAREVGEATGGPELSGVPRGESEETGSS-------EG 590
P PT + L + +PS V+ V E P +++E +S
Sbjct: 195 PVPIAPTAQPEELLNGAPSPPAVDLSPVSE----------PEEQAKEVTASMAPPTIPSA 244
Query: 591 APSLLPATRAPEGTRELEAPSEDNSGRTAPAGTSVQ---AQPVLPTDS 635
P+ P+ +P E+E E+ G AG + + +LP +S
Sbjct: 245 TPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELLPPES 292
>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
[Homo sapiens]
Length = 1451
Score = 52.0 bits (123), Expect = 2e-06
Identities = 76/321 (23%), Positives = 122/321 (38%), Gaps = 52/321 (16%)
Query: 354 RDSAQPSA----IPEASNPASNPA-----SDGLEAIVTVTETLEELQLPQEATESESRGA 404
R SA+PSA + E S PA G+ + + E+ + T+ E + +
Sbjct: 158 RKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPS 217
Query: 405 IYSIPIMEDGGGGSSTPEDPAE----APRTLLEFETQSMVPPTGFSEEEGKALEEEEKYE 460
+ + ST E PA AP + + Q +G AL ++ +
Sbjct: 218 VKPAQVK---ASSVSTKESPARKAAPAPGKVGDVTPQV----------KGGALPPAKRAK 264
Query: 461 D-EEEKEEEEEEEEVEDEALWAWPSELSSPGPEASLPTEPAAQEESLSQAPARAVLQPGA 519
EEE E EE E E+EA G + + + + APA+ GA
Sbjct: 265 KPEEESESSEEGSESEEEA---------PAGTRSQVKASEKILQVRAASAPAKGTPGKGA 315
Query: 520 SPLPDGESEASRPPRVHGPPTETLPTPRERNLAS----PSPSTLVEAREVGEATGGPELS 575
+P P G++ A G P E + E + S P+ L++A+ G+ T +
Sbjct: 316 TPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGK-TSQVGAA 374
Query: 576 GVPRGESEETGSSEGAPSLL-PA-TRAPEGTRELEAPS--------EDNSGRTAPAGTSV 625
P ES G++ P PA +A G RE ++ S E+ + P+G +
Sbjct: 375 SAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAP 434
Query: 626 QAQPV-LPTDSASRGGVAVVP 645
Q + P + R G A P
Sbjct: 435 QVRAASAPAKESPRKGAAPAP 455
Score = 41.6 bits (96), Expect = 0.002
Identities = 62/309 (20%), Positives = 116/309 (37%), Gaps = 40/309 (12%)
Query: 363 PEASNPASNPASDGLEAIVTVTETLEELQLPQEATESESRGAIYSIPIMEDGGGGSSTPE 422
P + A++PA A+ T+ E E ++SE ++ + + G
Sbjct: 666 PRKAGTATSPAGSS-PAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQV 724
Query: 423 DPAEAP-RTLLEFETQSMVPPTGFSEEEGKALEEEEKYEDEEEKEEEEEEEEVEDEALWA 481
A P + L T ++P GK + + E++++ E EEE + E A
Sbjct: 725 KAASVPVKGSLGQGTAPVLP--------GKTGPTVTQVKAEKQEDSESSEEESDSEEAAA 776
Query: 482 WPSELSSPGPEASLPTEPAAQEESLSQAPAR--AVLQPGASPLPDGESEASRPPRVHGPP 539
P+++ + + PAA ++AP+ + PG +++ P +V P
Sbjct: 777 SPAQVKTSVKKTQAKANPAA-----ARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPP- 830
Query: 540 TETLPTPRERNLASPSPSTLVEARE----VGEATGGPELSGVPRGESEETGSSEGAPSLL 595
+ P+ + + P+++ + +A GPE G SEE SE L
Sbjct: 831 ---VRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDS---GSSEEESDSEEEAETL 884
Query: 596 PATRAPEGTRELE---APSEDN---------SGRTAPAGTSVQAQPVLPTDSASRGGVAV 643
+ T ++ AP++++ G+T P+ Q + S
Sbjct: 885 AQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGE 944
Query: 644 VPASGNSAQ 652
PA+ SAQ
Sbjct: 945 APAAVTSAQ 953
Score = 35.4 bits (80), Expect = 0.17
Identities = 69/314 (21%), Positives = 109/314 (34%), Gaps = 64/314 (20%)
Query: 356 SAQPSAIPEASNPASNPASDGLEAIVTVTETLEELQLPQ------EATESESRGAIYSIP 409
+AQ PE + +S SD E T+ + + Q A ES +GA + P
Sbjct: 857 AAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPP 916
Query: 410 -----------IMEDGGGGSSTPEDPAEAPRTLLEFETQSMVPPTGFSEE---------- 448
+D G S + EAP + Q + PP F +
Sbjct: 917 GKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTS--AQVIKPPLIFVDPNRSPAGPAAT 974
Query: 449 --EGKALEEEEKYEDEEEKEEEEEEEEVEDEALWAWPSELSSPGPEASLPTEPAAQEESL 506
+ +A K E E +++ + A ++ +PG ++ T P A
Sbjct: 975 PAQAQAASTPRKARASESTARSSSSESEDEDVIPA--TQCLTPGIRTNVVTMPTAHPRIA 1032
Query: 507 SQAP-ARAVLQPGASPLPDGESEASRPPRVHGPPTETLPTPRERNLASPSPSTLVEAREV 565
+A A A +S + DG+ + GP T+ SP ST V+A+
Sbjct: 1033 PKASMAGASSSKESSRISDGKKQ-------EGPATQVDSAVGTLPATSPQ-STSVQAKGT 1084
Query: 566 GEATGGPELSGVPRGESEETGSSEGAPSLLPATRAPEGTRELEAPSEDNSGR----TAPA 621
+ P+L P + AT+APE + + E S+ +SG P
Sbjct: 1085 NKLRK-PKL-----------------PEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQ 1126
Query: 622 GTSVQAQPVLPTDS 635
G V PT S
Sbjct: 1127 GAKSAHTLVGPTPS 1140
Score = 34.7 bits (78), Expect = 0.29
Identities = 43/181 (23%), Positives = 67/181 (37%), Gaps = 12/181 (6%)
Query: 448 EEGKALEEEEKYEDE--EEKEEEEEEEEVEDEALWAWPSELSSPGPEASLPTEPAAQEES 505
EE AL+ ++ + E EEEEE E E A P L+S P++ +E
Sbjct: 66 EEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATP-RLASTNSSVLGADLPSSMKEK 124
Query: 506 LSQAPARAVLQPGASPLP-DGESEAS----RPPRVHGPPTETLPTPRERNLASPSPSTLV 560
+A + P P G++ A+ + PR P+ E P+
Sbjct: 125 AKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGA 184
Query: 561 EAREVGEATGGPELSGVPRGESEETGSSEGAPSLLPATRAPEGTRELEAPSEDNSGRTAP 620
A+ + G + S S + EG PS+ PA E+P+ + AP
Sbjct: 185 AAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPAR----KAAP 240
Query: 621 A 621
A
Sbjct: 241 A 241
Score = 32.7 bits (73), Expect = 1.1
Identities = 65/300 (21%), Positives = 106/300 (35%), Gaps = 62/300 (20%)
Query: 388 EELQLPQEATESESRGAIYSIPIMEDGGGGSSTPEDPAEAPRTLLEFETQSMVPPTGFSE 447
E+ Q E ++SE + P G + A AP + + PP
Sbjct: 408 EDSQSSSEESDSEEEAPAQAKP------SGKAPQVRAASAPAKESPRKGAAPAPP----R 457
Query: 448 EEGKALEEEEKYEDEEEKEEEEEEEEVEDEALWAWPSELSSPGPEASLPTEPAAQEESLS 507
+ G A + + + EE+ EE + + EAL A + P + S +PA+ ++
Sbjct: 458 KTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGK-SPQVKPAS---TMG 513
Query: 508 QAPARAVLQPGASPLPDGESEASRPPRVHGPPTETLPTPRERNLASPS---PSTLVEARE 564
P L GA P+P G+ + P G E + E + S P+ + A+E
Sbjct: 514 MGP----LGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQE 569
Query: 565 VG------------EATGGPELSGV---------------PRGESEETGSSEGAPSLLPA 597
A G P+ +G ES ++ SE AP+ + A
Sbjct: 570 KSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTA 629
Query: 598 TRAPEGTRELEA---PSEDN---SGRTAPAGTSVQAQPVLPTDSASRGGVAVVPASGNSA 651
+A + + P + N S + AP QA + G A PA + A
Sbjct: 630 AQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQA--------PRKAGTATSPAGSSPA 681
>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
[Homo sapiens]
Length = 1488
Score = 52.0 bits (123), Expect = 2e-06
Identities = 76/321 (23%), Positives = 122/321 (38%), Gaps = 52/321 (16%)
Query: 354 RDSAQPSA----IPEASNPASNPA-----SDGLEAIVTVTETLEELQLPQEATESESRGA 404
R SA+PSA + E S PA G+ + + E+ + T+ E + +
Sbjct: 158 RKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPS 217
Query: 405 IYSIPIMEDGGGGSSTPEDPAE----APRTLLEFETQSMVPPTGFSEEEGKALEEEEKYE 460
+ + ST E PA AP + + Q +G AL ++ +
Sbjct: 218 VKPAQVK---ASSVSTKESPARKAAPAPGKVGDVTPQV----------KGGALPPAKRAK 264
Query: 461 D-EEEKEEEEEEEEVEDEALWAWPSELSSPGPEASLPTEPAAQEESLSQAPARAVLQPGA 519
EEE E EE E E+EA G + + + + APA+ GA
Sbjct: 265 KPEEESESSEEGSESEEEA---------PAGTRSQVKASEKILQVRAASAPAKGTPGKGA 315
Query: 520 SPLPDGESEASRPPRVHGPPTETLPTPRERNLAS----PSPSTLVEAREVGEATGGPELS 575
+P P G++ A G P E + E + S P+ L++A+ G+ T +
Sbjct: 316 TPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGK-TSQVGAA 374
Query: 576 GVPRGESEETGSSEGAPSLL-PA-TRAPEGTRELEAPS--------EDNSGRTAPAGTSV 625
P ES G++ P PA +A G RE ++ S E+ + P+G +
Sbjct: 375 SAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAP 434
Query: 626 QAQPV-LPTDSASRGGVAVVP 645
Q + P + R G A P
Sbjct: 435 QVRAASAPAKESPRKGAAPAP 455
Score = 41.6 bits (96), Expect = 0.002
Identities = 62/309 (20%), Positives = 116/309 (37%), Gaps = 40/309 (12%)
Query: 363 PEASNPASNPASDGLEAIVTVTETLEELQLPQEATESESRGAIYSIPIMEDGGGGSSTPE 422
P + A++PA A+ T+ E E ++SE ++ + + G
Sbjct: 666 PRKAGTATSPAGSS-PAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQV 724
Query: 423 DPAEAP-RTLLEFETQSMVPPTGFSEEEGKALEEEEKYEDEEEKEEEEEEEEVEDEALWA 481
A P + L T ++P GK + + E++++ E EEE + E A
Sbjct: 725 KAASVPVKGSLGQGTAPVLP--------GKTGPTVTQVKAEKQEDSESSEEESDSEEAAA 776
Query: 482 WPSELSSPGPEASLPTEPAAQEESLSQAPAR--AVLQPGASPLPDGESEASRPPRVHGPP 539
P+++ + + PAA ++AP+ + PG +++ P +V P
Sbjct: 777 SPAQVKTSVKKTQAKANPAA-----ARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPP- 830
Query: 540 TETLPTPRERNLASPSPSTLVEARE----VGEATGGPELSGVPRGESEETGSSEGAPSLL 595
+ P+ + + P+++ + +A GPE G SEE SE L
Sbjct: 831 ---VRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDS---GSSEEESDSEEEAETL 884
Query: 596 PATRAPEGTRELE---APSEDN---------SGRTAPAGTSVQAQPVLPTDSASRGGVAV 643
+ T ++ AP++++ G+T P+ Q + S
Sbjct: 885 AQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGE 944
Query: 644 VPASGNSAQ 652
PA+ SAQ
Sbjct: 945 APAAVTSAQ 953
Score = 36.2 bits (82), Expect = 0.10
Identities = 62/303 (20%), Positives = 108/303 (35%), Gaps = 46/303 (15%)
Query: 356 SAQPSAIPEASNPASNPASDGLEAIVTVTETLEELQLPQ------EATESESRGAIYSIP 409
+AQ PE + +S SD E T+ + + Q A ES +GA + P
Sbjct: 857 AAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPP 916
Query: 410 -----------IMEDGGGGSSTPEDPAEAPRTLLEFETQSMVPPTGFSEE---------- 448
+D G S + EAP + Q + PP F +
Sbjct: 917 GKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTS--AQVIKPPLIFVDPNRSPAGPAAT 974
Query: 449 --EGKALEEEEKYEDEEEKEEEEEEEEVEDEALWAWPSELSSPGPEASLPTEPAAQEESL 506
+ +A K E E +++ + A ++ +PG ++ T P A
Sbjct: 975 PAQAQAASTPRKARASESTARSSSSESEDEDVIPA--TQCLTPGIRTNVVTMPTAHPRIA 1032
Query: 507 SQAP-ARAVLQPGASPLPDGESEASRPPRVHGPPTETLPTPR--------ERNLASPSPS 557
+A A A +S + DG+ + +V +LP + + + A P +
Sbjct: 1033 PKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVA 1092
Query: 558 TLVEAREVGEATGGPELSGVPRGESEETGSSEGAPSLLP----ATRAPEGTRELEAPSED 613
+ V A G + + G+++ LP AT+APE + + E S+
Sbjct: 1093 RTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDS 1152
Query: 614 NSG 616
+SG
Sbjct: 1153 SSG 1155
Score = 34.7 bits (78), Expect = 0.29
Identities = 43/181 (23%), Positives = 67/181 (37%), Gaps = 12/181 (6%)
Query: 448 EEGKALEEEEKYEDE--EEKEEEEEEEEVEDEALWAWPSELSSPGPEASLPTEPAAQEES 505
EE AL+ ++ + E EEEEE E E A P L+S P++ +E
Sbjct: 66 EEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATP-RLASTNSSVLGADLPSSMKEK 124
Query: 506 LSQAPARAVLQPGASPLP-DGESEAS----RPPRVHGPPTETLPTPRERNLASPSPSTLV 560
+A + P P G++ A+ + PR P+ E P+
Sbjct: 125 AKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGA 184
Query: 561 EAREVGEATGGPELSGVPRGESEETGSSEGAPSLLPATRAPEGTRELEAPSEDNSGRTAP 620
A+ + G + S S + EG PS+ PA E+P+ + AP
Sbjct: 185 AAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPAR----KAAP 240
Query: 621 A 621
A
Sbjct: 241 A 241
Score = 32.7 bits (73), Expect = 1.1
Identities = 65/300 (21%), Positives = 106/300 (35%), Gaps = 62/300 (20%)
Query: 388 EELQLPQEATESESRGAIYSIPIMEDGGGGSSTPEDPAEAPRTLLEFETQSMVPPTGFSE 447
E+ Q E ++SE + P G + A AP + + PP
Sbjct: 408 EDSQSSSEESDSEEEAPAQAKP------SGKAPQVRAASAPAKESPRKGAAPAPP----R 457
Query: 448 EEGKALEEEEKYEDEEEKEEEEEEEEVEDEALWAWPSELSSPGPEASLPTEPAAQEESLS 507
+ G A + + + EE+ EE + + EAL A + P + S +PA+ ++
Sbjct: 458 KTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGK-SPQVKPAS---TMG 513
Query: 508 QAPARAVLQPGASPLPDGESEASRPPRVHGPPTETLPTPRERNLASPS---PSTLVEARE 564
P L GA P+P G+ + P G E + E + S P+ + A+E
Sbjct: 514 MGP----LGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQE 569
Query: 565 VG------------EATGGPELSGV---------------PRGESEETGSSEGAPSLLPA 597
A G P+ +G ES ++ SE AP+ + A
Sbjct: 570 KSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTA 629
Query: 598 TRAPEGTRELEA---PSEDN---SGRTAPAGTSVQAQPVLPTDSASRGGVAVVPASGNSA 651
+A + + P + N S + AP QA + G A PA + A
Sbjct: 630 AQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQA--------PRKAGTATSPAGSSPA 681
>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a
[Homo sapiens]
Length = 1450
Score = 52.0 bits (123), Expect = 2e-06
Identities = 76/321 (23%), Positives = 122/321 (38%), Gaps = 52/321 (16%)
Query: 354 RDSAQPSA----IPEASNPASNPA-----SDGLEAIVTVTETLEELQLPQEATESESRGA 404
R SA+PSA + E S PA G+ + + E+ + T+ E + +
Sbjct: 158 RKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPS 217
Query: 405 IYSIPIMEDGGGGSSTPEDPAE----APRTLLEFETQSMVPPTGFSEEEGKALEEEEKYE 460
+ + ST E PA AP + + Q +G AL ++ +
Sbjct: 218 VKPAQVK---ASSVSTKESPARKAAPAPGKVGDVTPQV----------KGGALPPAKRAK 264
Query: 461 D-EEEKEEEEEEEEVEDEALWAWPSELSSPGPEASLPTEPAAQEESLSQAPARAVLQPGA 519
EEE E EE E E+EA G + + + + APA+ GA
Sbjct: 265 KPEEESESSEEGSESEEEA---------PAGTRSQVKASEKILQVRAASAPAKGTPGKGA 315
Query: 520 SPLPDGESEASRPPRVHGPPTETLPTPRERNLAS----PSPSTLVEAREVGEATGGPELS 575
+P P G++ A G P E + E + S P+ L++A+ G+ T +
Sbjct: 316 TPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGK-TSQVGAA 374
Query: 576 GVPRGESEETGSSEGAPSLL-PA-TRAPEGTRELEAPS--------EDNSGRTAPAGTSV 625
P ES G++ P PA +A G RE ++ S E+ + P+G +
Sbjct: 375 SAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAP 434
Query: 626 QAQPV-LPTDSASRGGVAVVP 645
Q + P + R G A P
Sbjct: 435 QVRAASAPAKESPRKGAAPAP 455
Score = 41.6 bits (96), Expect = 0.002
Identities = 62/309 (20%), Positives = 116/309 (37%), Gaps = 40/309 (12%)
Query: 363 PEASNPASNPASDGLEAIVTVTETLEELQLPQEATESESRGAIYSIPIMEDGGGGSSTPE 422
P + A++PA A+ T+ E E ++SE ++ + + G
Sbjct: 666 PRKAGTATSPAGSS-PAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQV 724
Query: 423 DPAEAP-RTLLEFETQSMVPPTGFSEEEGKALEEEEKYEDEEEKEEEEEEEEVEDEALWA 481
A P + L T ++P GK + + E++++ E EEE + E A
Sbjct: 725 KAASVPVKGSLGQGTAPVLP--------GKTGPTVTQVKAEKQEDSESSEEESDSEEAAA 776
Query: 482 WPSELSSPGPEASLPTEPAAQEESLSQAPAR--AVLQPGASPLPDGESEASRPPRVHGPP 539
P+++ + + PAA ++AP+ + PG +++ P +V P
Sbjct: 777 SPAQVKTSVKKTQAKANPAA-----ARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPP- 830
Query: 540 TETLPTPRERNLASPSPSTLVEARE----VGEATGGPELSGVPRGESEETGSSEGAPSLL 595
+ P+ + + P+++ + +A GPE G SEE SE L
Sbjct: 831 ---VRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDS---GSSEEESDSEEEAETL 884
Query: 596 PATRAPEGTRELE---APSEDN---------SGRTAPAGTSVQAQPVLPTDSASRGGVAV 643
+ T ++ AP++++ G+T P+ Q + S
Sbjct: 885 AQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGE 944
Query: 644 VPASGNSAQ 652
PA+ SAQ
Sbjct: 945 APAAVTSAQ 953
Score = 35.0 bits (79), Expect = 0.22
Identities = 63/291 (21%), Positives = 103/291 (35%), Gaps = 60/291 (20%)
Query: 356 SAQPSAIPEASNPASNPASDGLEAIVTVTETLEELQLPQ------EATESESRGAIYSIP 409
+AQ PE + +S SD E T+ + + Q A ES +GA + P
Sbjct: 857 AAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPP 916
Query: 410 -----------IMEDGGGGSSTPEDPAEAPRTLLEFETQSMVPPTGFSEE---------- 448
+D G S + EAP + Q + PP F +
Sbjct: 917 GKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTS--AQVIKPPLIFVDPNRSPAGPAAT 974
Query: 449 --EGKALEEEEKYEDEEEKEEEEEEEEVEDEALWAWPSELSSPGPEASLPTEPAAQEESL 506
+ +A K E E +++ + A ++ +PG ++ T P A
Sbjct: 975 PAQAQAASTPRKARASESTARSSSSESEDEDVIPA--TQCLTPGIRTNVVTMPTAHPRIA 1032
Query: 507 SQAP-ARAVLQPGASPLPDGESEASRPPRVHGPPTETLPTPRERNLASPSPSTLVEAREV 565
+A A A +S + DG+ + GP T+ SP ST V+A+
Sbjct: 1033 PKASMAGASSSKESSRISDGKKQ-------EGPATQVDSAVGTLPATSPQ-STSVQAKGT 1084
Query: 566 GEATGGPELSGVPRGESEETGSSEGAPSLLPATRAPEGTRELEAPSEDNSG 616
+ P+L P + AT+APE + + E S+ +SG
Sbjct: 1085 NKLRK-PKL-----------------PEVQQATKAPESSDDSEDSSDSSSG 1117
Score = 34.7 bits (78), Expect = 0.29
Identities = 43/181 (23%), Positives = 67/181 (37%), Gaps = 12/181 (6%)
Query: 448 EEGKALEEEEKYEDE--EEKEEEEEEEEVEDEALWAWPSELSSPGPEASLPTEPAAQEES 505
EE AL+ ++ + E EEEEE E E A P L+S P++ +E
Sbjct: 66 EEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATP-RLASTNSSVLGADLPSSMKEK 124
Query: 506 LSQAPARAVLQPGASPLP-DGESEAS----RPPRVHGPPTETLPTPRERNLASPSPSTLV 560
+A + P P G++ A+ + PR P+ E P+
Sbjct: 125 AKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGA 184
Query: 561 EAREVGEATGGPELSGVPRGESEETGSSEGAPSLLPATRAPEGTRELEAPSEDNSGRTAP 620
A+ + G + S S + EG PS+ PA E+P+ + AP
Sbjct: 185 AAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPAR----KAAP 240
Query: 621 A 621
A
Sbjct: 241 A 241
Score = 32.7 bits (73), Expect = 1.1
Identities = 65/300 (21%), Positives = 106/300 (35%), Gaps = 62/300 (20%)
Query: 388 EELQLPQEATESESRGAIYSIPIMEDGGGGSSTPEDPAEAPRTLLEFETQSMVPPTGFSE 447
E+ Q E ++SE + P G + A AP + + PP
Sbjct: 408 EDSQSSSEESDSEEEAPAQAKP------SGKAPQVRAASAPAKESPRKGAAPAPP----R 457
Query: 448 EEGKALEEEEKYEDEEEKEEEEEEEEVEDEALWAWPSELSSPGPEASLPTEPAAQEESLS 507
+ G A + + + EE+ EE + + EAL A + P + S +PA+ ++
Sbjct: 458 KTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGK-SPQVKPAS---TMG 513
Query: 508 QAPARAVLQPGASPLPDGESEASRPPRVHGPPTETLPTPRERNLASPS---PSTLVEARE 564
P L GA P+P G+ + P G E + E + S P+ + A+E
Sbjct: 514 MGP----LGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQE 569
Query: 565 VG------------EATGGPELSGV---------------PRGESEETGSSEGAPSLLPA 597
A G P+ +G ES ++ SE AP+ + A
Sbjct: 570 KSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTA 629
Query: 598 TRAPEGTRELEA---PSEDN---SGRTAPAGTSVQAQPVLPTDSASRGGVAVVPASGNSA 651
+A + + P + N S + AP QA + G A PA + A
Sbjct: 630 AQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQA--------PRKAGTATSPAGSSPA 681
>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c
[Homo sapiens]
Length = 958
Score = 52.0 bits (123), Expect = 2e-06
Identities = 76/321 (23%), Positives = 122/321 (38%), Gaps = 52/321 (16%)
Query: 354 RDSAQPSA----IPEASNPASNPA-----SDGLEAIVTVTETLEELQLPQEATESESRGA 404
R SA+PSA + E S PA G+ + + E+ + T+ E + +
Sbjct: 158 RKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPS 217
Query: 405 IYSIPIMEDGGGGSSTPEDPAE----APRTLLEFETQSMVPPTGFSEEEGKALEEEEKYE 460
+ + ST E PA AP + + Q +G AL ++ +
Sbjct: 218 VKPAQVK---ASSVSTKESPARKAAPAPGKVGDVTPQV----------KGGALPPAKRAK 264
Query: 461 D-EEEKEEEEEEEEVEDEALWAWPSELSSPGPEASLPTEPAAQEESLSQAPARAVLQPGA 519
EEE E EE E E+EA G + + + + APA+ GA
Sbjct: 265 KPEEESESSEEGSESEEEA---------PAGTRSQVKASEKILQVRAASAPAKGTPGKGA 315
Query: 520 SPLPDGESEASRPPRVHGPPTETLPTPRERNLAS----PSPSTLVEAREVGEATGGPELS 575
+P P G++ A G P E + E + S P+ L++A+ G+ T +
Sbjct: 316 TPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGK-TSQVGAA 374
Query: 576 GVPRGESEETGSSEGAPSLL-PA-TRAPEGTRELEAPS--------EDNSGRTAPAGTSV 625
P ES G++ P PA +A G RE ++ S E+ + P+G +
Sbjct: 375 SAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAP 434
Query: 626 QAQPV-LPTDSASRGGVAVVP 645
Q + P + R G A P
Sbjct: 435 QVRAASAPAKESPRKGAAPAP 455
Score = 41.6 bits (96), Expect = 0.002
Identities = 62/309 (20%), Positives = 116/309 (37%), Gaps = 40/309 (12%)
Query: 363 PEASNPASNPASDGLEAIVTVTETLEELQLPQEATESESRGAIYSIPIMEDGGGGSSTPE 422
P + A++PA A+ T+ E E ++SE ++ + + G
Sbjct: 666 PRKAGTATSPAGSS-PAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQV 724
Query: 423 DPAEAP-RTLLEFETQSMVPPTGFSEEEGKALEEEEKYEDEEEKEEEEEEEEVEDEALWA 481
A P + L T ++P GK + + E++++ E EEE + E A
Sbjct: 725 KAASVPVKGSLGQGTAPVLP--------GKTGPTVTQVKAEKQEDSESSEEESDSEEAAA 776
Query: 482 WPSELSSPGPEASLPTEPAAQEESLSQAPAR--AVLQPGASPLPDGESEASRPPRVHGPP 539
P+++ + + PAA ++AP+ + PG +++ P +V P
Sbjct: 777 SPAQVKTSVKKTQAKANPAA-----ARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPP- 830
Query: 540 TETLPTPRERNLASPSPSTLVEARE----VGEATGGPELSGVPRGESEETGSSEGAPSLL 595
+ P+ + + P+++ + +A GPE G SEE SE L
Sbjct: 831 ---VRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDS---GSSEEESDSEEEAETL 884
Query: 596 PATRAPEGTRELE---APSEDN---------SGRTAPAGTSVQAQPVLPTDSASRGGVAV 643
+ T ++ AP++++ G+T P+ Q + S
Sbjct: 885 AQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGE 944
Query: 644 VPASGNSAQ 652
PA+ SAQ
Sbjct: 945 APAAVTSAQ 953
Score = 34.7 bits (78), Expect = 0.29
Identities = 43/181 (23%), Positives = 67/181 (37%), Gaps = 12/181 (6%)
Query: 448 EEGKALEEEEKYEDE--EEKEEEEEEEEVEDEALWAWPSELSSPGPEASLPTEPAAQEES 505
EE AL+ ++ + E EEEEE E E A P L+S P++ +E
Sbjct: 66 EEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATP-RLASTNSSVLGADLPSSMKEK 124
Query: 506 LSQAPARAVLQPGASPLP-DGESEAS----RPPRVHGPPTETLPTPRERNLASPSPSTLV 560
+A + P P G++ A+ + PR P+ E P+
Sbjct: 125 AKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGA 184
Query: 561 EAREVGEATGGPELSGVPRGESEETGSSEGAPSLLPATRAPEGTRELEAPSEDNSGRTAP 620
A+ + G + S S + EG PS+ PA E+P+ + AP
Sbjct: 185 AAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPAR----KAAP 240
Query: 621 A 621
A
Sbjct: 241 A 241
Score = 32.7 bits (73), Expect = 1.1
Identities = 65/300 (21%), Positives = 106/300 (35%), Gaps = 62/300 (20%)
Query: 388 EELQLPQEATESESRGAIYSIPIMEDGGGGSSTPEDPAEAPRTLLEFETQSMVPPTGFSE 447
E+ Q E ++SE + P G + A AP + + PP
Sbjct: 408 EDSQSSSEESDSEEEAPAQAKP------SGKAPQVRAASAPAKESPRKGAAPAPP----R 457
Query: 448 EEGKALEEEEKYEDEEEKEEEEEEEEVEDEALWAWPSELSSPGPEASLPTEPAAQEESLS 507
+ G A + + + EE+ EE + + EAL A + P + S +PA+ ++
Sbjct: 458 KTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGK-SPQVKPAS---TMG 513
Query: 508 QAPARAVLQPGASPLPDGESEASRPPRVHGPPTETLPTPRERNLASPS---PSTLVEARE 564
P L GA P+P G+ + P G E + E + S P+ + A+E
Sbjct: 514 MGP----LGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQE 569
Query: 565 VG------------EATGGPELSGV---------------PRGESEETGSSEGAPSLLPA 597
A G P+ +G ES ++ SE AP+ + A
Sbjct: 570 KSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTA 629
Query: 598 TRAPEGTRELEA---PSEDN---SGRTAPAGTSVQAQPVLPTDSASRGGVAVVPASGNSA 651
+A + + P + N S + AP QA + G A PA + A
Sbjct: 630 AQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQA--------PRKAGTATSPAGSSPA 681
>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
9 [Homo sapiens]
Length = 771
Score = 52.0 bits (123), Expect = 2e-06
Identities = 45/150 (30%), Positives = 65/150 (43%), Gaps = 13/150 (8%)
Query: 422 EDPAEAPRTLLEFETQSMVPPTGFSEEEGKALEEEEKYEDEEEKEEEEEEEEVEDEALWA 481
+D +++ R E+ S +G EEE + EEEE+ EE EEEEEEEE E+E
Sbjct: 256 QDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEE---- 311
Query: 482 WPSELSSPGPEASLPTEPAAQEESLSQAPAR------AVLQPGASPLPDGESEASRPPRV 535
E S EAS + EE +S+ R V+ GESE +
Sbjct: 312 ---ETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVG 368
Query: 536 HGPPTETLPTPRERNLASPSPSTLVEAREV 565
G P + T + SP+ S + +E+
Sbjct: 369 EGTPQSSALTEGDYVPDSPALSPIELKQEL 398
Score = 30.0 bits (66), Expect = 7.2
Identities = 39/161 (24%), Positives = 54/161 (33%), Gaps = 51/161 (31%)
Query: 385 ETLEELQLP---QEATESESRGAIYSIPIMEDGGGGSSTPEDPAEAPRTLLEFETQSMVP 441
E +EE L Q+ ++SE + + E G G E+ E
Sbjct: 244 EKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEE--------------- 288
Query: 442 PTGFSEEEGKALEEEEKYEDEEEKEEE------------------------EEEEEVEDE 477
EEEG EE E+ E+EEE+EEE +EE E E+
Sbjct: 289 ----EEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENH 344
Query: 478 ALWAWPSELSSPGPEASLPTEPAAQEESLSQAPARAVLQPG 518
L S E+ A+EE P + L G
Sbjct: 345 LLVVPESRFDRDSGESE-----EAEEEVGEGTPQSSALTEG 380
>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
8 [Homo sapiens]
Length = 780
Score = 52.0 bits (123), Expect = 2e-06
Identities = 45/150 (30%), Positives = 65/150 (43%), Gaps = 13/150 (8%)
Query: 422 EDPAEAPRTLLEFETQSMVPPTGFSEEEGKALEEEEKYEDEEEKEEEEEEEEVEDEALWA 481
+D +++ R E+ S +G EEE + EEEE+ EE EEEEEEEE E+E
Sbjct: 265 QDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEE---- 320
Query: 482 WPSELSSPGPEASLPTEPAAQEESLSQAPAR------AVLQPGASPLPDGESEASRPPRV 535
E S EAS + EE +S+ R V+ GESE +
Sbjct: 321 ---ETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVG 377
Query: 536 HGPPTETLPTPRERNLASPSPSTLVEAREV 565
G P + T + SP+ S + +E+
Sbjct: 378 EGTPQSSALTEGDYVPDSPALSPIELKQEL 407
Score = 30.0 bits (66), Expect = 7.2
Identities = 39/161 (24%), Positives = 54/161 (33%), Gaps = 51/161 (31%)
Query: 385 ETLEELQLP---QEATESESRGAIYSIPIMEDGGGGSSTPEDPAEAPRTLLEFETQSMVP 441
E +EE L Q+ ++SE + + E G G E+ E
Sbjct: 253 EKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEE--------------- 297
Query: 442 PTGFSEEEGKALEEEEKYEDEEEKEEE------------------------EEEEEVEDE 477
EEEG EE E+ E+EEE+EEE +EE E E+
Sbjct: 298 ----EEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENH 353
Query: 478 ALWAWPSELSSPGPEASLPTEPAAQEESLSQAPARAVLQPG 518
L S E+ A+EE P + L G
Sbjct: 354 LLVVPESRFDRDSGESE-----EAEEEVGEGTPQSSALTEG 389
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.131 0.388
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,925,127
Number of Sequences: 37866
Number of extensions: 1968340
Number of successful extensions: 36004
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 596
Number of HSP's successfully gapped in prelim test: 1249
Number of HSP's that attempted gapping in prelim test: 15171
Number of HSP's gapped (non-prelim): 10488
length of query: 671
length of database: 18,247,518
effective HSP length: 109
effective length of query: 562
effective length of database: 14,120,124
effective search space: 7935509688
effective search space used: 7935509688
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.