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Search of human proteins with 38158013
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|38158013 MAM domain containing 1 isoform 2 [Homo sapiens]
(727 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|164698517 MAM domain containing 1 isoform 1 [Homo sapiens] 1487 0.0
gi|38158013 MAM domain containing 1 isoform 2 [Homo sapiens] 1487 0.0
gi|24111244 MAM domain containing glycosylphosphatidylinositol a... 719 0.0
gi|239755250 PREDICTED: chromosome 10 open reading frame 112 [Ho... 116 6e-26
gi|239749752 PREDICTED: chromosome 10 open reading frame 112 [Ho... 116 6e-26
gi|239744011 PREDICTED: chromosome 10 open reading frame 112 [Ho... 116 6e-26
gi|28373122 contactin 4 isoform a precursor [Homo sapiens] 115 1e-25
gi|7657359 contactin 5 isoform long [Homo sapiens] 112 2e-24
gi|28373129 contactin 5 isoform short [Homo sapiens] 112 2e-24
gi|223278413 MAM domain containing 2 [Homo sapiens] 105 1e-22
gi|4827022 contactin 2 precursor [Homo sapiens] 103 6e-22
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens] 100 4e-21
gi|118572606 hemicentin 1 [Homo sapiens] 100 4e-21
gi|109150416 peroxidasin [Homo sapiens] 99 2e-20
gi|75709184 contactin 3 [Homo sapiens] 97 4e-20
gi|110349719 titin isoform N2-A [Homo sapiens] 97 5e-20
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 95 2e-19
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 95 2e-19
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 95 2e-19
gi|224994173 roundabout 1 isoform d [Homo sapiens] 94 3e-19
gi|224994171 roundabout 1 isoform c [Homo sapiens] 94 3e-19
gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo ... 94 3e-19
gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo ... 94 3e-19
gi|182508169 neuropilin 1 isoform a [Homo sapiens] 93 8e-19
gi|223942069 enterokinase precursor [Homo sapiens] 92 1e-18
gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo ... 92 2e-18
gi|134244585 putative neuronal cell adhesion molecule [Homo sapi... 91 5e-18
gi|19743806 roundabout 1 isoform b [Homo sapiens] 90 6e-18
gi|4506569 roundabout 1 isoform a [Homo sapiens] 90 6e-18
gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens] 90 8e-18
>gi|164698517 MAM domain containing 1 isoform 1 [Homo sapiens]
Length = 956
Score = 1487 bits (3850), Expect = 0.0
Identities = 727/727 (100%), Positives = 727/727 (100%)
Query: 1 MVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTV 60
MVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTV
Sbjct: 230 MVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTV 289
Query: 61 LNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNI 120
LNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNI
Sbjct: 290 LNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNI 349
Query: 121 QIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKF 180
QIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKF
Sbjct: 350 QIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKF 409
Query: 181 TDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTG 240
TDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTG
Sbjct: 410 TDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTG 469
Query: 241 KPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPRE 300
KPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPRE
Sbjct: 470 KPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPRE 529
Query: 301 ALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFD 360
ALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFD
Sbjct: 530 ALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFD 589
Query: 361 SQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVTGKAYAPEFYYDTYNPVWQNRHR 420
SQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVTGKAYAPEFYYDTYNPVWQNRHR
Sbjct: 590 SQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVTGKAYAPEFYYDTYNPVWQNRHR 649
Query: 421 VYSYSLQWTQMNPDAVDRIVAYRLGIRQAGQQRWWEQEIKINGNIQKGELITYNLTELIK 480
VYSYSLQWTQMNPDAVDRIVAYRLGIRQAGQQRWWEQEIKINGNIQKGELITYNLTELIK
Sbjct: 650 VYSYSLQWTQMNPDAVDRIVAYRLGIRQAGQQRWWEQEIKINGNIQKGELITYNLTELIK 709
Query: 481 PEAYEVRLTPLTKFGEGDSTIRVIKYSAPVNPHLREFHCGFEDGNICLFTQDDTDNFDWT 540
PEAYEVRLTPLTKFGEGDSTIRVIKYSAPVNPHLREFHCGFEDGNICLFTQDDTDNFDWT
Sbjct: 710 PEAYEVRLTPLTKFGEGDSTIRVIKYSAPVNPHLREFHCGFEDGNICLFTQDDTDNFDWT 769
Query: 541 KQSTATRNTKYTPNTGPNADRSGSKEGFYMYIETSRPRLEGEKARLLSPVFSIAPKNPYG 600
KQSTATRNTKYTPNTGPNADRSGSKEGFYMYIETSRPRLEGEKARLLSPVFSIAPKNPYG
Sbjct: 770 KQSTATRNTKYTPNTGPNADRSGSKEGFYMYIETSRPRLEGEKARLLSPVFSIAPKNPYG 829
Query: 601 PTNTAYCFSFFYHMYGQHIGVLNVYLRLKGQTTIENPLWSSSGNKGQRWNEAHVNIYPIT 660
PTNTAYCFSFFYHMYGQHIGVLNVYLRLKGQTTIENPLWSSSGNKGQRWNEAHVNIYPIT
Sbjct: 830 PTNTAYCFSFFYHMYGQHIGVLNVYLRLKGQTTIENPLWSSSGNKGQRWNEAHVNIYPIT 889
Query: 661 SFQLIFEGIRGPGIEGDIAIDDVSIAEGECAKQDLATKNSVDGAVGILVHIWLFPIIVLI 720
SFQLIFEGIRGPGIEGDIAIDDVSIAEGECAKQDLATKNSVDGAVGILVHIWLFPIIVLI
Sbjct: 890 SFQLIFEGIRGPGIEGDIAIDDVSIAEGECAKQDLATKNSVDGAVGILVHIWLFPIIVLI 949
Query: 721 SILSPRR 727
SILSPRR
Sbjct: 950 SILSPRR 956
Score = 95.9 bits (237), Expect = 1e-19
Identities = 95/380 (25%), Positives = 161/380 (42%), Gaps = 36/380 (9%)
Query: 25 VNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEK----TVLNGGTLTIPAITSDDAGTYS 80
+ GE + L C+ TG P P + W ++ G+ ++ +V N TL I I G Y
Sbjct: 52 IREGETLELTCLVTG-HPRPQIRWTKTAGSASDRFQDSSVFNE-TLRITNIQRHQGGRYY 109
Query: 81 CIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEEL 140
C A N +G+PA KS + V L + + R V + C + P +
Sbjct: 110 CKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNP--PV 167
Query: 141 TFSWFKNGRPLRSSERMVITQTDPDVSPGTTN-LDIIDLKFTDFGTYTCVASLKG-GGIS 198
+SW + L + +P + G T L + +L+ D+ Y+C+AS++ I
Sbjct: 168 RYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIP 227
Query: 199 DISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVT-GKPKPIILWSRADKEVAM 257
D + +S+ T P++ + + P+V G+ I L C T G+P P + W R+ +
Sbjct: 228 DKMVSFRLSNKTASPSIKLLVD-DPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFG--TL 284
Query: 258 PDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIV------QYPP 311
P+ ++ GTL I ++ + +G Y C + G P + +IV ++
Sbjct: 285 PEKTV---LNGGTLTIPAITSDDAGTYSCIANNNVG---NPAKKSTNIIVRALKKGRFWI 338
Query: 312 AVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTG------QFD---SQ 362
+P + R V +SC+V A P LT+ W + LR+ Q D S
Sbjct: 339 TPDPYHKDDNIQIGREVKISCQV-EAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSP 397
Query: 363 EYTEYAVKSLSNENYGVYNC 382
T + L ++G Y C
Sbjct: 398 GTTNLDIIDLKFTDFGTYTC 417
>gi|38158013 MAM domain containing 1 isoform 2 [Homo sapiens]
Length = 727
Score = 1487 bits (3850), Expect = 0.0
Identities = 727/727 (100%), Positives = 727/727 (100%)
Query: 1 MVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTV 60
MVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTV
Sbjct: 1 MVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTV 60
Query: 61 LNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNI 120
LNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNI
Sbjct: 61 LNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNI 120
Query: 121 QIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKF 180
QIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKF
Sbjct: 121 QIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKF 180
Query: 181 TDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTG 240
TDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTG
Sbjct: 181 TDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTG 240
Query: 241 KPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPRE 300
KPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPRE
Sbjct: 241 KPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPRE 300
Query: 301 ALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFD 360
ALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFD
Sbjct: 301 ALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFD 360
Query: 361 SQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVTGKAYAPEFYYDTYNPVWQNRHR 420
SQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVTGKAYAPEFYYDTYNPVWQNRHR
Sbjct: 361 SQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVTGKAYAPEFYYDTYNPVWQNRHR 420
Query: 421 VYSYSLQWTQMNPDAVDRIVAYRLGIRQAGQQRWWEQEIKINGNIQKGELITYNLTELIK 480
VYSYSLQWTQMNPDAVDRIVAYRLGIRQAGQQRWWEQEIKINGNIQKGELITYNLTELIK
Sbjct: 421 VYSYSLQWTQMNPDAVDRIVAYRLGIRQAGQQRWWEQEIKINGNIQKGELITYNLTELIK 480
Query: 481 PEAYEVRLTPLTKFGEGDSTIRVIKYSAPVNPHLREFHCGFEDGNICLFTQDDTDNFDWT 540
PEAYEVRLTPLTKFGEGDSTIRVIKYSAPVNPHLREFHCGFEDGNICLFTQDDTDNFDWT
Sbjct: 481 PEAYEVRLTPLTKFGEGDSTIRVIKYSAPVNPHLREFHCGFEDGNICLFTQDDTDNFDWT 540
Query: 541 KQSTATRNTKYTPNTGPNADRSGSKEGFYMYIETSRPRLEGEKARLLSPVFSIAPKNPYG 600
KQSTATRNTKYTPNTGPNADRSGSKEGFYMYIETSRPRLEGEKARLLSPVFSIAPKNPYG
Sbjct: 541 KQSTATRNTKYTPNTGPNADRSGSKEGFYMYIETSRPRLEGEKARLLSPVFSIAPKNPYG 600
Query: 601 PTNTAYCFSFFYHMYGQHIGVLNVYLRLKGQTTIENPLWSSSGNKGQRWNEAHVNIYPIT 660
PTNTAYCFSFFYHMYGQHIGVLNVYLRLKGQTTIENPLWSSSGNKGQRWNEAHVNIYPIT
Sbjct: 601 PTNTAYCFSFFYHMYGQHIGVLNVYLRLKGQTTIENPLWSSSGNKGQRWNEAHVNIYPIT 660
Query: 661 SFQLIFEGIRGPGIEGDIAIDDVSIAEGECAKQDLATKNSVDGAVGILVHIWLFPIIVLI 720
SFQLIFEGIRGPGIEGDIAIDDVSIAEGECAKQDLATKNSVDGAVGILVHIWLFPIIVLI
Sbjct: 661 SFQLIFEGIRGPGIEGDIAIDDVSIAEGECAKQDLATKNSVDGAVGILVHIWLFPIIVLI 720
Query: 721 SILSPRR 727
SILSPRR
Sbjct: 721 SILSPRR 727
>gi|24111244 MAM domain containing glycosylphosphatidylinositol
anchor 1 [Homo sapiens]
Length = 955
Score = 719 bits (1857), Expect = 0.0
Identities = 345/700 (49%), Positives = 488/700 (69%), Gaps = 17/700 (2%)
Query: 2 VSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVL 61
++FRL+N TA P++KL V++ +VVNPGE +T+ C+ TGG+P P L W G LP +
Sbjct: 229 ITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLGALA 288
Query: 62 NGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQ 121
GGTL+IP++ + D+G Y+C A NNVGNPAKK+ N++VR++K F ITPD + +NIQ
Sbjct: 289 QGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKESENIQ 348
Query: 122 IGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFT 181
+G+++K+SC V+AVP E++T+ WFKNG+P R S+R+++T+ DP++ T++L++IDL F+
Sbjct: 349 LGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELIDLHFS 408
Query: 182 DFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGK 241
D+GTY C+AS G + D+S++VNISS TVPP ++VP+ ++ + REG ELQC+V GK
Sbjct: 409 DYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVRGK 468
Query: 242 PKPIILWSRADKEVA-MPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPRE 300
P+P +LWSR DKE A +P G E+ DG LR+ VSR+MSG YRCQT++YNGFNV+PRE
Sbjct: 469 PRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTARYNGFNVRPRE 528
Query: 301 ALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLR----- 355
A VQL VQ+PP VEP+ ++RQ R V + C +LR P R+ + WR +LL
Sbjct: 529 AQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVV 588
Query: 356 TGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVTGKAYAPEFYYDTYNPVW 415
++ ++ E + +++ ++ G Y CS+ N+ G+ C F V+ KAY+PEFY+DT NP
Sbjct: 589 PAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQVSAKAYSPEFYFDTPNPTR 648
Query: 416 QNR-HRVYSYSLQWTQMNPDAVDRIVAYRLGIRQAGQQRWWEQEIKINGNIQKGELITYN 474
++ + YSY LQWTQ PDAVD ++ YRL IRQ Q + I + ++KG+L+ Y
Sbjct: 649 SHKLSKNYSYVLQWTQREPDAVDPVLNYRLSIRQLNQHNAVVKAIPVR-RVEKGQLLEYI 707
Query: 475 LTELIKPEAYEVRLTPLTKFGEGDSTIRVIKYSAPVN-PHLREFHCGFEDGNICLFTQDD 533
LT+L P +YEVRLTP T FG GD R+I Y+ P+N P+L + C FED IC +TQD
Sbjct: 708 LTDLRVPHSYEVRLTPYTTFGAGDMASRIIHYTEPINSPNLSDNTCHFEDEKICGYTQDL 767
Query: 534 TDNFDWTKQSTATRNTKYTPNTGPNADRSGSKEGFYMYIETSRPRLEGEKARLLSPVFSI 593
TDNFDWT+Q+ T+N K +PNTGP D SG+ EG+YM+IETSRPR G++ARL+SP+++
Sbjct: 768 TDNFDWTRQNALTQNPKRSPNTGPPTDISGTPEGYYMFIETSRPRELGDRARLVSPLYNA 827
Query: 594 APKNPYGPTNTAYCFSFFYHMYGQHIGVLNVYLRLKGQTTIENPLWSSSGNKGQRWNEAH 653
+ K YC SFFYHMYG+HIG LN+ +R + + ++ WS SGNKG W +AH
Sbjct: 828 SAK--------FYCVSFFYHMYGKHIGSLNLLVRSRNKGALDTHAWSLSGNKGNVWQQAH 879
Query: 654 VNIYPITSFQLIFEGIRGPGIEGDIAIDDVSIAEGECAKQ 693
V I P FQ+IFEG+RGPG GDIAIDDV++ +GEC ++
Sbjct: 880 VPISPSGPFQIIFEGVRGPGYLGDIAIDDVTLKKGECPRK 919
Score = 111 bits (278), Expect = 2e-24
Identities = 106/381 (27%), Positives = 167/381 (43%), Gaps = 38/381 (9%)
Query: 25 VNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEK---TVLNGGTLTIPAITSDDAGTYSC 81
+ G+ + L C+ TG P P + W ++ G+ +K T + TL I I G Y C
Sbjct: 50 IREGDTLMLQCLVTG-HPRPQVRWTKTAGSASDKFQETSVFNETLRIERIARTQGGRYYC 108
Query: 82 IANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELT 141
A N VG PA KS + V+ L + + N + V + C V + P
Sbjct: 109 KAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPAR-- 166
Query: 142 FSWFKNGRPLRSSERMVITQTDPDVSPGTTN-LDIIDLKFTDFGTYTCVASLKG-GGISD 199
F W + L S+ + +P + G T L + +L+ D+ +YTC S++ GI D
Sbjct: 167 FIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPD 226
Query: 200 ISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVT-GKPKPIILWSRADKEVAMP 258
+I ++++T PP L + ++ LV G+ + +QC +T G P P + WS +P
Sbjct: 227 KAITFRLTNTTAPPALKLSVNET-LVVNPGENVTVQCLLTGGDPLPQLQWSHGPG--PLP 283
Query: 259 DGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIV--------QYP 310
G++ + GTL I +V SG Y C + G P + V L+V Q
Sbjct: 284 LGAL---AQGGTLSIPSVQARDSGYYNCTATNNVG---NPAKKTVNLLVRSMKNATFQIT 337
Query: 311 PAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEW-------RLGNKLLRTGQFDSQE 363
P V I+ GQD + +SC V A P +TY+W R+ +LL T
Sbjct: 338 PDVIKESENIQLGQD--LKLSCHV-DAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELP 394
Query: 364 YTEYAVK--SLSNENYGVYNC 382
+++ L +YG Y C
Sbjct: 395 AVTSSLELIDLHFSDYGTYLC 415
Score = 62.0 bits (149), Expect = 2e-09
Identities = 49/177 (27%), Positives = 82/177 (46%), Gaps = 30/177 (16%)
Query: 227 REGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRC 286
REGDT+ LQC VTG P+P + W++ + D + ++ TLRI ++R G Y C
Sbjct: 51 REGDTLMLQCLVTGHPRPQVRWTKTAGSAS--DKFQETSVFNETLRIERIARTQGGRYYC 108
Query: 287 QTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQG---------QDRSVTMSCRVLRA 337
+ NG V P +++ VQY ++ L + Q Q+++V + C V
Sbjct: 109 KAE--NGVGV-PAIKSIRVDVQY---LDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSN 162
Query: 338 YPIRVLTYEWRLGNKLLRTGQFDSQE-----YTE-----YAVKSLSNENYGVYNCSI 384
P R + W+ G+ L Q + + YT+ +K+L ++Y Y C +
Sbjct: 163 PPARFI---WKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQV 216
>gi|239755250 PREDICTED: chromosome 10 open reading frame 112 [Homo
sapiens]
Length = 1542
Score = 116 bits (291), Expect = 6e-26
Identities = 72/178 (40%), Positives = 97/178 (54%), Gaps = 24/178 (13%)
Query: 516 EFHCGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPNADRS-GSKEGFYMYIET 574
E C FE G IC + QD D+FDWT+ T T NTGP D + G+ +G Y+YIE+
Sbjct: 227 ELQCNFETG-ICNWEQDAKDDFDWTRNQGPTP----TLNTGPMKDNTLGTAKGHYLYIES 281
Query: 575 SRPRLEGEKARLLSPVFSIAPKNPYGPTNTAYC-FSFFYHMYGQHIGVLNVYLRL----K 629
S P+ + A LLSP+ + T+T C F F+YHM+G+ I L +Y R+ +
Sbjct: 282 SEPQAFQDSAALLSPILNA--------TDTKGCTFRFYYHMFGKRIYRLAIYQRIWSDSR 333
Query: 630 GQTTIENPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGPGIEGDIAIDDVSIAE 687
GQ LW GN+G RW H+NI FQ++ E G G GDIAIDD+S +
Sbjct: 334 GQL-----LWQIFGNQGNRWIRKHLNISSRQPFQILVEASVGDGFTGDIAIDDLSFMD 386
Score = 78.2 bits (191), Expect = 3e-14
Identities = 55/172 (31%), Positives = 86/172 (50%), Gaps = 20/172 (11%)
Query: 519 CGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPNADRS-GSKEGFYMYIETSRP 577
C FE ++C + Q+ ++FDW ++++ T P AD + G+ G Y++I + P
Sbjct: 672 CDFEF-DLCSWKQEKDEDFDWNLKASSIP----AAGTEPAADHTLGNSSGHYIFINSLFP 726
Query: 578 RLEGEKARLLSPVFSIAPKNPYGPTNTAYC-FSFFYHMYGQHIGVLNVY-LRLKGQTTIE 635
+ AR+ SPV S KN C F YHMYG IG L + + + QT +
Sbjct: 727 QQPMRAARISSPVISKRSKN---------CKIIFHYHMYGNGIGALTLMQVSVTNQTKV- 776
Query: 636 NPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGPGIEGDIAIDDVSIAE 687
L + + +G W ++++ FQL FEG G G GDIA+DD+ + E
Sbjct: 777 --LLNLTVEQGNFWRREELSLFGDEDFQLKFEGRVGKGQRGDIALDDIVLTE 826
Score = 69.3 bits (168), Expect = 1e-11
Identities = 47/177 (26%), Positives = 88/177 (49%), Gaps = 21/177 (11%)
Query: 519 CGFEDGNICLFTQ-------DDTDNFDWTKQSTATRNTKYTPNTGPNADRS-GSKEGFYM 570
C FE ++C + Q D++ F W + + + N P+ D + + +G+Y+
Sbjct: 455 CSFEKRSLCKWYQPIPVHLLQDSNTFRWGLGNGISIHHG-EENHRPSVDHTQNTTDGWYL 513
Query: 571 YIETSRPRLEGEKARLLSPVFSIAPKNPYGPTNTAYCFSFFYHMYGQHIGVLNVYLRLKG 630
Y ++S + G+ A +L+P+ S+ GP T F+ HM G +G L V ++
Sbjct: 514 YADSSNGKF-GDTADILTPIISLT-----GPKCTLV---FWTHMNGATVGSLQVLIK--- 561
Query: 631 QTTIENPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGPGIEGDIAIDDVSIAE 687
+ + + LW+ +G +G +W A V + + Q++F RG GD+A+DD+S +
Sbjct: 562 KDNVTSKLWAQTGQQGAQWKRAEVFLGIRSHTQIVFRAKRGISYIGDVAVDDISFQD 618
Score = 55.1 bits (131), Expect = 2e-07
Identities = 40/166 (24%), Positives = 71/166 (42%), Gaps = 11/166 (6%)
Query: 519 CGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPNADRSGSKEGFYMYIETSRPR 578
C FE + F D+FDW + S + + + P + +G +M+I
Sbjct: 19 CDFEANSCDWFEAISGDHFDWIRSSQSELSADFEHQAPPRDHSLNASQGHFMFILKKSSS 78
Query: 579 LEGEKARLLSPVFSIAPKNPYGPTNTAYCFSFFYHMYGQHIGVLNVYLRLKGQTTIENPL 638
L + A+L SP FS T SF+++ YG +G + L ++ +
Sbjct: 79 L-WQVAKLQSPTFS--------QTGPGCILSFWFYNYGLSVGAAELQLHMENSHD-STVI 128
Query: 639 WSSSGNKGQRWNEAHVNIYPITS-FQLIFEGIRGPGIEGDIAIDDV 683
W N+G++W EA + + ++ F L + + +G AIDD+
Sbjct: 129 WRVLYNQGKQWLEATIQLGRLSQPFHLSLDKVSLGIYDGVSAIDDI 174
Score = 47.0 bits (110), Expect = 6e-05
Identities = 47/179 (26%), Positives = 74/179 (41%), Gaps = 24/179 (13%)
Query: 519 CGFE--DGN---ICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPNADRSGSKEGFYMYIE 573
C FE GN C TQD D+ DW S P++D + ++Y+
Sbjct: 1164 CNFETSSGNWTTACSLTQDSEDDLDWAIGSRIPAKALI-----PDSDHTPGSGQHFLYVN 1218
Query: 574 TSRPRLEGEKARLLSPVFSIAPKNPYGPTNTAYCFS--FFYHMYGQHIGVLNVYLRLKGQ 631
+S + EG AR+ + + P + C +FY + + +G+L VY +
Sbjct: 1219 SSGSK-EGSVARITT--------SKSFPASLGMCTVRFWFYMIDPRSMGILKVYTIEESG 1269
Query: 632 TTIENPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGPGIEGDIAIDDVSIAEGEC 690
I +WS GNK W V + + F++ FE + IA+DD+S EC
Sbjct: 1270 LNIL--VWSVIGNKRTGWTYGSVPLSSNSPFKVAFEADLDGNEDIFIALDDISFTP-EC 1325
>gi|239749752 PREDICTED: chromosome 10 open reading frame 112 [Homo
sapiens]
Length = 1817
Score = 116 bits (291), Expect = 6e-26
Identities = 72/178 (40%), Positives = 97/178 (54%), Gaps = 24/178 (13%)
Query: 516 EFHCGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPNADRS-GSKEGFYMYIET 574
E C FE G IC + QD D+FDWT+ T T NTGP D + G+ +G Y+YIE+
Sbjct: 502 ELQCNFETG-ICNWEQDAKDDFDWTRNQGPTP----TLNTGPMKDNTLGTAKGHYLYIES 556
Query: 575 SRPRLEGEKARLLSPVFSIAPKNPYGPTNTAYC-FSFFYHMYGQHIGVLNVYLRL----K 629
S P+ + A LLSP+ + T+T C F F+YHM+G+ I L +Y R+ +
Sbjct: 557 SEPQAFQDSAALLSPILNA--------TDTKGCTFRFYYHMFGKRIYRLAIYQRIWSDSR 608
Query: 630 GQTTIENPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGPGIEGDIAIDDVSIAE 687
GQ LW GN+G RW H+NI FQ++ E G G GDIAIDD+S +
Sbjct: 609 GQL-----LWQIFGNQGNRWIRKHLNISSRQPFQILVEASVGDGFTGDIAIDDLSFMD 661
Score = 78.6 bits (192), Expect = 2e-14
Identities = 55/172 (31%), Positives = 87/172 (50%), Gaps = 20/172 (11%)
Query: 519 CGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPNADRS-GSKEGFYMYIETSRP 577
C FE ++C + Q+ ++FDW ++++ T P AD + G+ G Y++I++ P
Sbjct: 947 CDFEF-DLCSWKQEKDEDFDWNLKASSIP----AAGTEPAADHTLGNSSGHYIFIKSLFP 1001
Query: 578 RLEGEKARLLSPVFSIAPKNPYGPTNTAYC-FSFFYHMYGQHIGVLNVY-LRLKGQTTIE 635
+ AR+ SPV S KN C F YHMYG IG L + + + QT +
Sbjct: 1002 QQPMRAARISSPVISKRSKN---------CKIIFHYHMYGNGIGALTLMQVSVTNQTKV- 1051
Query: 636 NPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGPGIEGDIAIDDVSIAE 687
L + + +G W ++++ FQL FEG G G GDIA+DD+ + E
Sbjct: 1052 --LLNLTVEQGNFWRREELSLFGDEDFQLKFEGRVGKGQRGDIALDDIVLTE 1101
Score = 69.3 bits (168), Expect = 1e-11
Identities = 47/177 (26%), Positives = 88/177 (49%), Gaps = 21/177 (11%)
Query: 519 CGFEDGNICLFTQ-------DDTDNFDWTKQSTATRNTKYTPNTGPNADRS-GSKEGFYM 570
C FE ++C + Q D++ F W + + + N P+ D + + +G+Y+
Sbjct: 730 CSFEKRSLCKWYQPIPVHLLQDSNTFRWGLGNGISIHHG-EENHRPSVDHTQNTTDGWYL 788
Query: 571 YIETSRPRLEGEKARLLSPVFSIAPKNPYGPTNTAYCFSFFYHMYGQHIGVLNVYLRLKG 630
Y ++S + G+ A +L+P+ S+ GP T F+ HM G +G L V ++
Sbjct: 789 YADSSNGKF-GDTADILTPIISLT-----GPKCTLV---FWTHMNGATVGSLQVLIK--- 836
Query: 631 QTTIENPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGPGIEGDIAIDDVSIAE 687
+ + + LW+ +G +G +W A V + + Q++F RG GD+A+DD+S +
Sbjct: 837 KDNVTSKLWAQTGQQGAQWKRAEVFLGIRSHTQIVFRAKRGISYIGDVAVDDISFQD 893
Score = 55.1 bits (131), Expect = 2e-07
Identities = 40/166 (24%), Positives = 71/166 (42%), Gaps = 11/166 (6%)
Query: 519 CGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPNADRSGSKEGFYMYIETSRPR 578
C FE + F D+FDW + S + + + P + +G +M+I
Sbjct: 294 CDFEANSCDWFEAISGDHFDWIRSSQSELSADFEHQAPPRDHSLNASQGHFMFILKKSSS 353
Query: 579 LEGEKARLLSPVFSIAPKNPYGPTNTAYCFSFFYHMYGQHIGVLNVYLRLKGQTTIENPL 638
L + A+L SP FS T SF+++ YG +G + L ++ +
Sbjct: 354 L-WQVAKLQSPTFS--------QTGPGCILSFWFYNYGLSVGAAELQLHMENSHD-STVI 403
Query: 639 WSSSGNKGQRWNEAHVNIYPITS-FQLIFEGIRGPGIEGDIAIDDV 683
W N+G++W EA + + ++ F L + + +G AIDD+
Sbjct: 404 WRVLYNQGKQWLEATIQLGRLSQPFHLSLDKVSLGIYDGVSAIDDI 449
Score = 47.0 bits (110), Expect = 6e-05
Identities = 47/179 (26%), Positives = 74/179 (41%), Gaps = 24/179 (13%)
Query: 519 CGFE--DGN---ICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPNADRSGSKEGFYMYIE 573
C FE GN C TQD D+ DW S P++D + ++Y+
Sbjct: 1439 CNFETSSGNWTTACSLTQDSEDDLDWAIGSRIPAKALI-----PDSDHTPGSGQHFLYVN 1493
Query: 574 TSRPRLEGEKARLLSPVFSIAPKNPYGPTNTAYCFS--FFYHMYGQHIGVLNVYLRLKGQ 631
+S + EG AR+ + + P + C +FY + + +G+L VY +
Sbjct: 1494 SSGSK-EGSVARITT--------SKSFPASLGMCTVRFWFYMIDPRSMGILKVYTIEESG 1544
Query: 632 TTIENPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGPGIEGDIAIDDVSIAEGEC 690
I +WS GNK W V + + F++ FE + IA+DD+S EC
Sbjct: 1545 LNIL--VWSVIGNKRTGWTYGSVPLSSNSPFKVAFEADLDGNEDIFIALDDISFTP-EC 1600
>gi|239744011 PREDICTED: chromosome 10 open reading frame 112 [Homo
sapiens]
Length = 1817
Score = 116 bits (291), Expect = 6e-26
Identities = 72/178 (40%), Positives = 97/178 (54%), Gaps = 24/178 (13%)
Query: 516 EFHCGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPNADRS-GSKEGFYMYIET 574
E C FE G IC + QD D+FDWT+ T T NTGP D + G+ +G Y+YIE+
Sbjct: 502 ELQCNFETG-ICNWEQDAKDDFDWTRSQGPTP----TLNTGPMKDNTLGTAKGHYLYIES 556
Query: 575 SRPRLEGEKARLLSPVFSIAPKNPYGPTNTAYC-FSFFYHMYGQHIGVLNVYLRL----K 629
S P+ + A LLSP+ + T+T C F F+YHM+G+ I L +Y R+ +
Sbjct: 557 SEPQAFQDSAALLSPILNA--------TDTKGCTFRFYYHMFGKRIYRLAIYQRIWSDSR 608
Query: 630 GQTTIENPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGPGIEGDIAIDDVSIAE 687
GQ LW GN+G RW H+NI FQ++ E G G GDIAIDD+S +
Sbjct: 609 GQL-----LWQIFGNQGNRWIRKHLNISSRQPFQILVEASVGDGFTGDIAIDDLSFMD 661
Score = 78.6 bits (192), Expect = 2e-14
Identities = 55/172 (31%), Positives = 87/172 (50%), Gaps = 20/172 (11%)
Query: 519 CGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPNADRS-GSKEGFYMYIETSRP 577
C FE ++C + Q+ ++FDW ++++ T P AD + G+ G Y++I++ P
Sbjct: 947 CDFEF-DLCSWKQEKDEDFDWNLKASSIP----AAGTEPAADHTLGNSSGHYIFIKSLFP 1001
Query: 578 RLEGEKARLLSPVFSIAPKNPYGPTNTAYC-FSFFYHMYGQHIGVLNVY-LRLKGQTTIE 635
+ AR+ SPV S KN C F YHMYG IG L + + + QT +
Sbjct: 1002 QQPMRAARISSPVISKRSKN---------CKIIFHYHMYGNGIGALTLMQVSVTNQTKV- 1051
Query: 636 NPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGPGIEGDIAIDDVSIAE 687
L + + +G W ++++ FQL FEG G G GDIA+DD+ + E
Sbjct: 1052 --LLNLTVEQGNFWRREELSLFGDEDFQLKFEGRVGKGQRGDIALDDIVLTE 1101
Score = 69.3 bits (168), Expect = 1e-11
Identities = 47/177 (26%), Positives = 88/177 (49%), Gaps = 21/177 (11%)
Query: 519 CGFEDGNICLFTQ-------DDTDNFDWTKQSTATRNTKYTPNTGPNADRS-GSKEGFYM 570
C FE ++C + Q D++ F W + + + N P+ D + + +G+Y+
Sbjct: 730 CSFEKRSLCKWYQPIPVHLLQDSNTFRWGLGNGISIHHG-EENHRPSVDHTQNTTDGWYL 788
Query: 571 YIETSRPRLEGEKARLLSPVFSIAPKNPYGPTNTAYCFSFFYHMYGQHIGVLNVYLRLKG 630
Y ++S + G+ A +L+P+ S+ GP T F+ HM G +G L V ++
Sbjct: 789 YADSSNGKF-GDTADILTPIISLT-----GPKCTLV---FWTHMNGATVGSLQVLIK--- 836
Query: 631 QTTIENPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGPGIEGDIAIDDVSIAE 687
+ + + LW+ +G +G +W A V + + Q++F RG GD+A+DD+S +
Sbjct: 837 KDNVTSKLWAQTGQQGAQWKRAEVFLGIRSHTQIVFRAKRGISYIGDVAVDDISFQD 893
Score = 55.1 bits (131), Expect = 2e-07
Identities = 40/166 (24%), Positives = 71/166 (42%), Gaps = 11/166 (6%)
Query: 519 CGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPNADRSGSKEGFYMYIETSRPR 578
C FE + F D+FDW + S + + + P + +G +M+I
Sbjct: 294 CDFEANSCDWFEAISGDHFDWIRSSQSELSADFEHQAPPRDHSLNASQGHFMFILKKSSS 353
Query: 579 LEGEKARLLSPVFSIAPKNPYGPTNTAYCFSFFYHMYGQHIGVLNVYLRLKGQTTIENPL 638
L + A+L SP FS T SF+++ YG +G + L ++ +
Sbjct: 354 L-WQVAKLQSPTFS--------QTGPGCILSFWFYNYGLSVGAAELQLHMENSHD-STVI 403
Query: 639 WSSSGNKGQRWNEAHVNIYPITS-FQLIFEGIRGPGIEGDIAIDDV 683
W N+G++W EA + + ++ F L + + +G AIDD+
Sbjct: 404 WRVLYNQGKQWLEATIQLGRLSQPFHLSLDKVSLGIYDGVSAIDDI 449
Score = 47.0 bits (110), Expect = 6e-05
Identities = 47/179 (26%), Positives = 74/179 (41%), Gaps = 24/179 (13%)
Query: 519 CGFE--DGN---ICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPNADRSGSKEGFYMYIE 573
C FE GN C TQD D+ DW S P++D + ++Y+
Sbjct: 1439 CNFETSSGNWTTACSLTQDSEDDLDWAIGSRIPAKALI-----PDSDHTPGSGQHFLYVN 1493
Query: 574 TSRPRLEGEKARLLSPVFSIAPKNPYGPTNTAYCFS--FFYHMYGQHIGVLNVYLRLKGQ 631
+S + EG AR+ + + P + C +FY + + +G+L VY +
Sbjct: 1494 SSGSK-EGSVARITT--------SKSFPASLGMCTVRFWFYMIDPRSMGILKVYTIEESG 1544
Query: 632 TTIENPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGPGIEGDIAIDDVSIAEGEC 690
I +WS GNK W V + + F++ FE + IA+DD+S EC
Sbjct: 1545 LNIL--VWSVIGNKRTGWTYGSVPLSSNSPFKVAFEADLDGNEDIFIALDDISFTP-EC 1600
>gi|28373122 contactin 4 isoform a precursor [Homo sapiens]
Length = 1026
Score = 115 bits (289), Expect = 1e-25
Identities = 115/503 (22%), Positives = 209/503 (41%), Gaps = 60/503 (11%)
Query: 13 PSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFG---TLPEKTVLNGGTLTIP 69
P I++ + + G + L C G P P++ W R+ G + + G L IP
Sbjct: 225 PKIEVQFPETVPTAKGATVKLECFALGN-PVPTIIWRRADGKPIARKARRHKSNGILEIP 283
Query: 70 AITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKIS 129
+DAG Y C+A N+ G + + F+ P+ K ++I + E +
Sbjct: 284 NFQQEDAGLYECVAENSRGKNVARG---------QLTFYAQPNWIQKINDIHVAMEENVF 334
Query: 130 CQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCV 189
+ +A + T+ W KNG PL + +R+ I Q GT N+ I++L +D G Y C+
Sbjct: 335 WECKANGRPKPTYKWLKNGEPLLTRDRIQIEQ-------GTLNITIVNL--SDAGMYQCL 385
Query: 190 ASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWS 249
A K G I + +S V P+ + K + + G + ++C+ PKP+ W
Sbjct: 386 AENKHGVIFS---NAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWK 442
Query: 250 RADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQY 309
+ +++ + + + S DG LRI+NV++ +G Y C + + G + L+V+
Sbjct: 443 KG-RDILKENERITI-SEDGNLRIINVTKSDAGSYTCIATNHFG----TASSTGNLVVKD 496
Query: 310 PP--AVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEW----------RLGNKLLRTG 357
P V P+ +++ G+ S+ + C+V + + ++ + W R G+ R G
Sbjct: 497 PTRVMVPPSSMDVTVGE--SIVLPCQVTHDHSLDIV-FTWSFNGHLIDFDRDGDHFERVG 553
Query: 358 QFDSQEYTEYAVKSLSNENYGVYNCSIINEAG--AGRCSFLVTGKAYAPEFYYDTYNPVW 415
DS + ++++ ++ G Y C + + +V G PE T + +
Sbjct: 554 GQDSA--GDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAV--TIDEIT 609
Query: 416 QNRHRVYSYSLQWTQMNPDAVDRIVAYRLGIRQAGQQRWWEQEIKINGNIQKGELITYNL 475
+ L W + PD I Y + R W Q + + G+ T +
Sbjct: 610 DT-----TAQLSW-RPGPDNHSPITMYVIQARTPFSVGW--QAVSTVPELIDGKTFTATV 661
Query: 476 TELIKPEAYEVRLTPLTKFGEGD 498
L YE R G G+
Sbjct: 662 VGLNPWVEYEFRTVAANVIGIGE 684
Score = 79.0 bits (193), Expect = 1e-14
Identities = 92/381 (24%), Positives = 150/381 (39%), Gaps = 40/381 (10%)
Query: 40 GEPAPSLTWVRSFGTLPEK------TVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKK 93
G P P + W + GT + +V+ G L + DAGTY C A N+ G +
Sbjct: 54 GNPKPHIRWKLN-GTDVDTGMDFRYSVVEGSLLINNPNKTQDAGTYQCTATNSFGTIVSR 112
Query: 94 STNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRS 153
+ L + +++ G+ + + C S EL+++W N P
Sbjct: 113 EAKLQFAYLDNFK-----TRTRSTVSVRRGQGMVLLCGPPP-HSGELSYAWIFNEYPSYQ 166
Query: 154 SERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKG------GGISDISIDVNIS 207
R ++Q T NL I ++ +D G YTCV + G + + + +
Sbjct: 167 DNRRFVSQE-------TGNLYIAKVEKSDVGNYTCVVTNTVTNHKVLGPPTPLILRNDGV 219
Query: 208 SSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRAD-KEVAMPDGSMQMES 266
P + V Q + T +G T++L+C G P P I+W RAD K +A +
Sbjct: 220 MGEYEPKIEV-QFPETVPTAKGATVKLECFALGNPVPTIIWRRADGKPIAR---KARRHK 275
Query: 267 YDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDR 326
+G L I N +E +G+Y C G NV A QL P +I +
Sbjct: 276 SNGILEIPNFQQEDAGLYECVAENSRGKNV----ARGQLTFYAQPNWIQKINDIHVAMEE 331
Query: 327 SVTMSCRVL-RAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSII 385
+V C+ R P TY+W + L T E + ++ + G+Y C
Sbjct: 332 NVFWECKANGRPKP----TYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAE 387
Query: 386 NEAGAGRCSFLVTGKAYAPEF 406
N+ G + ++ A P+F
Sbjct: 388 NKHGVIFSNAELSVIAVGPDF 408
Score = 38.5 bits (88), Expect = 0.022
Identities = 49/184 (26%), Positives = 78/184 (42%), Gaps = 31/184 (16%)
Query: 219 QEKSPLV---TREGDTIELQCQVTGKPKPIILW--SRADKEVAMPDGSMQMESYDGTLRI 273
QE SP++ E ++L C+V G PKP I W + D + M + +G+L I
Sbjct: 30 QEPSPVMFPLDSEEKKVKLNCEVKGNPKPHIRWKLNGTDVDTGM---DFRYSVVEGSLLI 86
Query: 274 VNVSR-EMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSC 332
N ++ + +G Y+C + G + REA +Q A+L+ + + RS T+S
Sbjct: 87 NNPNKTQDAGTYQCTATNSFG-TIVSREAKLQF----------AYLDNFKTRTRS-TVSV 134
Query: 333 R-----VLRAYP---IRVLTYEWRLGN--KLLRTGQFDSQEYTEYAVKSLSNENYGVYNC 382
R VL P L+Y W +F SQE + + + G Y C
Sbjct: 135 RRGQGMVLLCGPPPHSGELSYAWIFNEYPSYQDNRRFVSQETGNLYIAKVEKSDVGNYTC 194
Query: 383 SIIN 386
+ N
Sbjct: 195 VVTN 198
>gi|7657359 contactin 5 isoform long [Homo sapiens]
Length = 1100
Score = 112 bits (279), Expect = 2e-24
Identities = 120/504 (23%), Positives = 201/504 (39%), Gaps = 63/504 (12%)
Query: 13 PSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVL--NGGTLTIPA 70
P I++ + G + + C G P P++TW++ G +P K L + L IP
Sbjct: 300 PKIEVHFPFTVTAAKGTTVKMECFALGN-PVPTITWMKVNGYIPSKARLRKSQAVLEIPN 358
Query: 71 ITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYH----KDDNIQIGREV 126
+ DDAG Y C A N+ G + + G+ + P+ D + G +
Sbjct: 359 VQLDDAGIYECRAENSRGKNSFR-----------GQLQVYTYPHWVEKLNDTQLDSGSPL 407
Query: 127 KISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTY 186
+ C+ P T+ W KNG PL R+ + L I ++ +D G Y
Sbjct: 408 RWECKATGKPRP--TYRWLKNGVPLSPQSRVEMVNGV---------LMIHNVNQSDAGMY 456
Query: 187 TCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPII 246
C+A K G I S ++ I +S P + Q K ++ + + ++C+ G PKP I
Sbjct: 457 QCLAENKYGAIY-ASAELKILASA--PTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTI 513
Query: 247 LWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLI 306
W + D+ A+ + DG+LRI+N S+ G Y C+ G E + L
Sbjct: 514 SWKKGDR--AVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFG----SAEIIASLS 567
Query: 307 VQYPPAVE--PAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLL----RTGQFD 360
V+ P +E P E+ G+ S+ ++C+ + + V T+ W L + + G F+
Sbjct: 568 VKEPTRIELTPKRTELTVGE--SIVLNCKAIHDASLDV-TFYWTLKGQPIDFEEEGGHFE 624
Query: 361 S----QEYTEYAVKSLSNENYGVYNCSIINEAG--AGRCSFLVTGKAYAPEFYYDTYNPV 414
S + ++++ + G Y C + A + LV G P V
Sbjct: 625 SIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGI-------V 677
Query: 415 WQNRHRVYSYSLQWTQMNPDAVDRIVAYRLGIRQAGQQRWWEQEIKINGNIQKGELITYN 474
+ +L W+ D I +Y L R W Q +K I G++ +
Sbjct: 678 IVEEITESTATLSWSPA-ADNHSPISSYNLQARSPFSLGW--QTVKTVPEIITGDMESAM 734
Query: 475 LTELIKPEAYEVRLTPLTKFGEGD 498
+L YE R+ G GD
Sbjct: 735 AVDLNPWVEYEFRVVATNPIGTGD 758
Score = 62.8 bits (151), Expect = 1e-09
Identities = 82/385 (21%), Positives = 144/385 (37%), Gaps = 47/385 (12%)
Query: 40 GEPAPSLTWVRSFGTLPEKT-----VLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKS 94
G P PS W+R+ + ++ +++G + + D+G Y C+A N VG+ +
Sbjct: 127 GNPVPSYRWLRNGTEIDLESDYRYSLIDGTFIISNPSEAKDSGHYQCLATNTVGSILSRE 186
Query: 95 TNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSS 154
+ L G F +++ G+ V + C S E+ +SW N P
Sbjct: 187 ATLQFAYL--GNF---SGRTRSAVSVREGQGVVLMCS-PPPHSPEIIYSWVFNEFP---- 236
Query: 155 ERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPN 214
V + +S T NL I ++ +D G+Y C+ + + + + S P
Sbjct: 237 -SFVAEDSRRFISQETGNLYISKVQTSDVGSYICL-------VKNTVTNARVLSPPTPLT 288
Query: 215 LT---VPQEKSP---------LVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSM 262
L V E P + +G T++++C G P P I W + + +
Sbjct: 289 LRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKVNGYI---PSKA 345
Query: 263 QMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQ 322
++ L I NV + +G+Y C+ G N + V YP VE + +
Sbjct: 346 RLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQV---YTYPHWVE-KLNDTQL 401
Query: 323 GQDRSVTMSCRVL-RAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYN 381
+ C+ + P TY W L + +++ + G+Y
Sbjct: 402 DSGSPLRWECKATGKPRP----TYRWLKNGVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQ 457
Query: 382 CSIINEAGAGRCSFLVTGKAYAPEF 406
C N+ GA S + A AP F
Sbjct: 458 CLAENKYGAIYASAELKILASAPTF 482
Score = 55.5 bits (132), Expect = 2e-07
Identities = 74/350 (21%), Positives = 130/350 (37%), Gaps = 48/350 (13%)
Query: 23 IVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLNG--------GTLTIPAITSD 74
+ V G+ + L+C P +WV F P + G L I + +
Sbjct: 205 VSVREGQGVVLMCSPPPHSPEIIYSWV--FNEFPSFVAEDSRRFISQETGNLYISKVQTS 262
Query: 75 DAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYH-KDDNIQIGREVKISCQ-- 131
D G+Y C+ N V N R P P ++D + E KI
Sbjct: 263 DVGSYICLVKNTVTN---------------ARVLSPPTPLTLRNDGVMGEYEPKIEVHFP 307
Query: 132 --VEAVPSEELTFSWFKNGRPLRSSERMVITQTDPD---VSPGTTNLDIIDLKFTDFGTY 186
V A + F G P+ + M + P + L+I +++ D G Y
Sbjct: 308 FTVTAAKGTTVKMECFALGNPVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIY 367
Query: 187 TCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPII 246
C A G S + T P + ++ + G + +C+ TGKP+P
Sbjct: 368 ECRAENSRG---KNSFRGQLQVYTYPHWV---EKLNDTQLDSGSPLRWECKATGKPRPTY 421
Query: 247 LWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLI 306
W + ++ ++E +G L I NV++ +GMY+C N + A ++++
Sbjct: 422 RWLKNGVPLS---PQSRVEMVNGVLMIHNVNQSDAGMYQCLAE--NKYGAIYASAELKIL 476
Query: 307 VQYPP-AVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLR 355
P A+ I +D+ V + C+ + T W+ G++ +R
Sbjct: 477 ASAPTFALNQLKKTIIVTKDQEVVIECKPQGS---PKPTISWKKGDRAVR 523
Score = 38.1 bits (87), Expect = 0.029
Identities = 41/162 (25%), Positives = 66/162 (40%), Gaps = 14/162 (8%)
Query: 232 IELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSR-EMSGMYRCQTSQ 290
+ L C+V G P P W R E+ + + + DGT I N S + SG Y+C +
Sbjct: 119 VALNCEVRGNPVPSYRWLRNGTEIDL-ESDYRYSLIDGTFIISNPSEAKDSGHYQCLATN 177
Query: 291 YNGFNVKPREALVQL--IVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWR 348
G ++ REA +Q + + A + +R+GQ V + C P + Y W
Sbjct: 178 TVG-SILSREATLQFAYLGNFSGRTRSA-VSVREGQ--GVVLMCSPPPHSP--EIIYSWV 231
Query: 349 LGN----KLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIIN 386
+ +F SQE + + + G Y C + N
Sbjct: 232 FNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKN 273
>gi|28373129 contactin 5 isoform short [Homo sapiens]
Length = 1026
Score = 112 bits (279), Expect = 2e-24
Identities = 120/504 (23%), Positives = 201/504 (39%), Gaps = 63/504 (12%)
Query: 13 PSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVL--NGGTLTIPA 70
P I++ + G + + C G P P++TW++ G +P K L + L IP
Sbjct: 226 PKIEVHFPFTVTAAKGTTVKMECFALGN-PVPTITWMKVNGYIPSKARLRKSQAVLEIPN 284
Query: 71 ITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYH----KDDNIQIGREV 126
+ DDAG Y C A N+ G + + G+ + P+ D + G +
Sbjct: 285 VQLDDAGIYECRAENSRGKNSFR-----------GQLQVYTYPHWVEKLNDTQLDSGSPL 333
Query: 127 KISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTY 186
+ C+ P T+ W KNG PL R+ + L I ++ +D G Y
Sbjct: 334 RWECKATGKPRP--TYRWLKNGVPLSPQSRVEMVNGV---------LMIHNVNQSDAGMY 382
Query: 187 TCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPII 246
C+A K G I S ++ I +S P + Q K ++ + + ++C+ G PKP I
Sbjct: 383 QCLAENKYGAIY-ASAELKILASA--PTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTI 439
Query: 247 LWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLI 306
W + D+ A+ + DG+LRI+N S+ G Y C+ G E + L
Sbjct: 440 SWKKGDR--AVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFG----SAEIIASLS 493
Query: 307 VQYPPAVE--PAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLL----RTGQFD 360
V+ P +E P E+ G+ S+ ++C+ + + V T+ W L + + G F+
Sbjct: 494 VKEPTRIELTPKRTELTVGE--SIVLNCKAIHDASLDV-TFYWTLKGQPIDFEEEGGHFE 550
Query: 361 S----QEYTEYAVKSLSNENYGVYNCSIINEAG--AGRCSFLVTGKAYAPEFYYDTYNPV 414
S + ++++ + G Y C + A + LV G P V
Sbjct: 551 SIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGI-------V 603
Query: 415 WQNRHRVYSYSLQWTQMNPDAVDRIVAYRLGIRQAGQQRWWEQEIKINGNIQKGELITYN 474
+ +L W+ D I +Y L R W Q +K I G++ +
Sbjct: 604 IVEEITESTATLSWSPA-ADNHSPISSYNLQARSPFSLGW--QTVKTVPEIITGDMESAM 660
Query: 475 LTELIKPEAYEVRLTPLTKFGEGD 498
+L YE R+ G GD
Sbjct: 661 AVDLNPWVEYEFRVVATNPIGTGD 684
Score = 62.8 bits (151), Expect = 1e-09
Identities = 82/385 (21%), Positives = 144/385 (37%), Gaps = 47/385 (12%)
Query: 40 GEPAPSLTWVRSFGTLPEKT-----VLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKS 94
G P PS W+R+ + ++ +++G + + D+G Y C+A N VG+ +
Sbjct: 53 GNPVPSYRWLRNGTEIDLESDYRYSLIDGTFIISNPSEAKDSGHYQCLATNTVGSILSRE 112
Query: 95 TNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSS 154
+ L G F +++ G+ V + C S E+ +SW N P
Sbjct: 113 ATLQFAYL--GNF---SGRTRSAVSVREGQGVVLMCS-PPPHSPEIIYSWVFNEFP---- 162
Query: 155 ERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPN 214
V + +S T NL I ++ +D G+Y C+ + + + + S P
Sbjct: 163 -SFVAEDSRRFISQETGNLYISKVQTSDVGSYICL-------VKNTVTNARVLSPPTPLT 214
Query: 215 LT---VPQEKSP---------LVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSM 262
L V E P + +G T++++C G P P I W + + +
Sbjct: 215 LRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKVNGYI---PSKA 271
Query: 263 QMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQ 322
++ L I NV + +G+Y C+ G N + V YP VE + +
Sbjct: 272 RLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQV---YTYPHWVE-KLNDTQL 327
Query: 323 GQDRSVTMSCRVL-RAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYN 381
+ C+ + P TY W L + +++ + G+Y
Sbjct: 328 DSGSPLRWECKATGKPRP----TYRWLKNGVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQ 383
Query: 382 CSIINEAGAGRCSFLVTGKAYAPEF 406
C N+ GA S + A AP F
Sbjct: 384 CLAENKYGAIYASAELKILASAPTF 408
Score = 55.5 bits (132), Expect = 2e-07
Identities = 74/350 (21%), Positives = 130/350 (37%), Gaps = 48/350 (13%)
Query: 23 IVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLNG--------GTLTIPAITSD 74
+ V G+ + L+C P +WV F P + G L I + +
Sbjct: 131 VSVREGQGVVLMCSPPPHSPEIIYSWV--FNEFPSFVAEDSRRFISQETGNLYISKVQTS 188
Query: 75 DAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYH-KDDNIQIGREVKISCQ-- 131
D G+Y C+ N V N R P P ++D + E KI
Sbjct: 189 DVGSYICLVKNTVTN---------------ARVLSPPTPLTLRNDGVMGEYEPKIEVHFP 233
Query: 132 --VEAVPSEELTFSWFKNGRPLRSSERMVITQTDPD---VSPGTTNLDIIDLKFTDFGTY 186
V A + F G P+ + M + P + L+I +++ D G Y
Sbjct: 234 FTVTAAKGTTVKMECFALGNPVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIY 293
Query: 187 TCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPII 246
C A G S + T P + ++ + G + +C+ TGKP+P
Sbjct: 294 ECRAENSRG---KNSFRGQLQVYTYPHWV---EKLNDTQLDSGSPLRWECKATGKPRPTY 347
Query: 247 LWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLI 306
W + ++ ++E +G L I NV++ +GMY+C N + A ++++
Sbjct: 348 RWLKNGVPLS---PQSRVEMVNGVLMIHNVNQSDAGMYQCLAE--NKYGAIYASAELKIL 402
Query: 307 VQYPP-AVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLR 355
P A+ I +D+ V + C+ + T W+ G++ +R
Sbjct: 403 ASAPTFALNQLKKTIIVTKDQEVVIECKPQGS---PKPTISWKKGDRAVR 449
Score = 38.1 bits (87), Expect = 0.029
Identities = 41/162 (25%), Positives = 66/162 (40%), Gaps = 14/162 (8%)
Query: 232 IELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSR-EMSGMYRCQTSQ 290
+ L C+V G P P W R E+ + + + DGT I N S + SG Y+C +
Sbjct: 45 VALNCEVRGNPVPSYRWLRNGTEIDL-ESDYRYSLIDGTFIISNPSEAKDSGHYQCLATN 103
Query: 291 YNGFNVKPREALVQL--IVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWR 348
G ++ REA +Q + + A + +R+GQ V + C P + Y W
Sbjct: 104 TVG-SILSREATLQFAYLGNFSGRTRSA-VSVREGQ--GVVLMCSPPPHSP--EIIYSWV 157
Query: 349 LGN----KLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIIN 386
+ +F SQE + + + G Y C + N
Sbjct: 158 FNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKN 199
>gi|223278413 MAM domain containing 2 [Homo sapiens]
Length = 686
Score = 105 bits (263), Expect = 1e-22
Identities = 68/182 (37%), Positives = 92/182 (50%), Gaps = 16/182 (8%)
Query: 519 CGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPNADRSGSKEGFYMYIETSRPR 578
C FE C FTQ+ + W ++ R T TGP D + + G+YMYIE S
Sbjct: 509 CTFEQDE-CTFTQEKRNRSSWHRR----RGETPTSYTGPKGDHT-TGVGYYMYIEASH-M 561
Query: 579 LEGEKARLLSPVFSIAPKNPYGPTNTAYCFSFFYHMYGQHIGVLNVYLRLKGQTTIENPL 638
+ G+KARLLS P + +C +FFYHMYG G+L+VYL+ K + + E+ L
Sbjct: 562 VYGQKARLLS--------RPLRGVSGKHCLTFFYHMYGGGTGLLSVYLK-KEEDSEESLL 612
Query: 639 WSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGPGIEGDIAIDDVSIAEGECAKQDLATK 698
W G + W A + Q+IFE IRG I DIAIDDV G C + + T+
Sbjct: 613 WRRRGEQSISWLRALIEYSCERQHQIIFEAIRGVSIRSDIAIDDVKFQAGPCGEMEDTTQ 672
Query: 699 NS 700
S
Sbjct: 673 QS 674
Score = 58.9 bits (141), Expect = 2e-08
Identities = 48/179 (26%), Positives = 79/179 (44%), Gaps = 22/179 (12%)
Query: 519 CGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPNADRSGSKEGFYMYIETSRPR 578
C FE+ ++C F N +W + RN + P S+ G YMY+++ +
Sbjct: 170 CDFEENHLCGFVNRWNPNVNWFVGGGSIRNVH---SILPQDHTFKSELGHYMYVDSVYVK 226
Query: 579 LEGEKARLLSPVFSIAPKNPYGPTNTAYCFSFFYHMYGQHIGVLNVYLRLKGQTTIENPL 638
E A+L+SP+ + AP A C SF+Y + + V ++Y R + +
Sbjct: 227 HFQEVAQLISPL-TTAP--------MAGCLSFYYQIQQGNDNVFSLYTR--DVAGLYEEI 275
Query: 639 WSSSGNKGQRWNEAHVNI---YPI-TSFQLIFEGIRGPGIEGDIAIDDVSIAEGECAKQ 693
W + WN A V YP+ F++ F G +G G +A+DD+S + C Q
Sbjct: 276 WKADRPGNAAWNLAEVEFSAPYPMEVIFEVAFNGPKG----GYVALDDISFSPVHCQNQ 330
Score = 45.1 bits (105), Expect = 2e-04
Identities = 44/182 (24%), Positives = 72/182 (39%), Gaps = 23/182 (12%)
Query: 516 EFHCGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPNADRSGSKEGFYMYIETS 575
E C FE ++C F QD + WT+ K PN D + G+Y+ T
Sbjct: 339 EASCNFEQ-DLCNFYQDK-EGPGWTR-------VKVKPNMYRAGDHTTGL-GYYLLANTK 388
Query: 576 RPRLEGEKARLLSPVFSIAPKNPYGPTNTAYCFSFFYHMYG--QHIGVLNVYLRLKGQTT 633
G RL P P N YC F Y +YG + L VY+ +
Sbjct: 389 FTSQPGYIGRLYGPSL---------PGNLQYCLRFHYAIYGFLKMSDTLAVYI-FEENHV 438
Query: 634 IENPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGPGIE-GDIAIDDVSIAEGECAK 692
++ +WS + W +A + +++F + + G +A+DD++I G C+
Sbjct: 439 VQEKIWSVLESPRGVWMQAEITFKKPMPTKVVFMSLCKSFWDCGLVALDDITIQLGSCSS 498
Query: 693 QD 694
+
Sbjct: 499 SE 500
Score = 44.3 bits (103), Expect = 4e-04
Identities = 35/137 (25%), Positives = 65/137 (47%), Gaps = 18/137 (13%)
Query: 564 SKEGFYMYIETSRPRLEGEKARLLSPVFSIAPKNPYGPTNTAYCFSFFYHMYGQHIGV-- 621
++EG Y+Y++TS + +GEKA LLSP + C Y + +
Sbjct: 47 NEEGHYIYVDTSFGK-QGEKAVLLSPDLQAEEWS---------CLRLVYQITTSSESLSD 96
Query: 622 ---LNVYLRLKGQTTIENPLWSSSGNKGQRWNEAHVNIYPITS-FQLIFEGIRGPGIEGD 677
LN+Y+R + ++ + LWS+ W A +++ + F+++ EG+ G G
Sbjct: 97 PSQLNLYMRFEDES-FDRLLWSAK-EPSDSWLIASLDLQNSSKKFKILIEGVLGQGNTAS 154
Query: 678 IAIDDVSIAEGECAKQD 694
IA+ ++ + G C + D
Sbjct: 155 IALFEIKMTTGYCIECD 171
>gi|4827022 contactin 2 precursor [Homo sapiens]
Length = 1040
Score = 103 bits (257), Expect = 6e-22
Identities = 89/338 (26%), Positives = 137/338 (40%), Gaps = 29/338 (8%)
Query: 12 SPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLNGGTLTIPAI 71
+PSIK G+ +TL C G P P + W + G+L + TL IP++
Sbjct: 238 APSIKARFPAETYALVGQQVTLECFAFGN-PVPRIKWRKVDGSLSPQWTTAEPTLQIPSV 296
Query: 72 TSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQ 131
+ +D GTY C A N+ G + IIV+A + W+ D IG ++ C
Sbjct: 297 SFEDEGTYECEAENSKGRDTVQG-RIIVQAQPE---WL---KVISDTEADIGSNLRWGCA 349
Query: 132 VEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVAS 191
P T W +NG PL S R+ + D L L D G Y CVA
Sbjct: 350 AAGKPRP--TVRWLRNGEPLASQNRVEVLAGD---------LRFSKLSLEDSGMYQCVAE 398
Query: 192 LKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRA 251
K G I ++ + P+ + + + G I + CQ PK ++LWS+
Sbjct: 399 NKHG---TIYASAELAVQALAPDFRLNPVRRLIPAARGGEILIPCQPRAAPKAVVLWSKG 455
Query: 252 DKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPP 311
+ + + S + DGTL I N+SR G Y C + G ++ +
Sbjct: 456 TE--ILVNSSRVTVTPDGTLIIRNISRSDEGKYTCFAENFMG--KANSTGILSVRDATKI 511
Query: 312 AVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRL 349
+ P+ +I G ++T+ C P LT+ W L
Sbjct: 512 TLAPSSADINLGD--NLTLQCHASHD-PTMDLTFTWTL 546
Score = 65.9 bits (159), Expect = 1e-10
Identities = 88/366 (24%), Positives = 140/366 (38%), Gaps = 43/366 (11%)
Query: 61 LNGGTLTIPAIT-SDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDN 119
L GG L I T + DAG Y C+A+N VG + + L++ + K++
Sbjct: 90 LVGGNLVIMNPTKAQDAGVYQCLASNPVGTVVSREAILRFGFLQE---------FSKEER 140
Query: 120 IQI----GREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDI 175
+ G V + C A L++ W N P + T VS T NL I
Sbjct: 141 DPVKAHEGWGVMLPCNPPA-HYPGLSYRWLLNEFP-----NFIPTDGRHFVSQTTGNLYI 194
Query: 176 IDLKFTDFGTYTCVAS--LKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTRE----G 229
+D G Y+C+A+ + S S ++ + L P K+ G
Sbjct: 195 ARTNASDLGNYSCLATSHMDFSTKSVFSKFAQLNLAAEDTRLFAPSIKARFPAETYALVG 254
Query: 230 DTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTS 289
+ L+C G P P I W + D + S Q + + TL+I +VS E G Y C+
Sbjct: 255 QQVTLECFAFGNPVPRIKWRKVDGSL-----SPQWTTAEPTLQIPSVSFEDEGTYECEAE 309
Query: 290 QYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVL-TYEWR 348
G + +VQ +P +L++ + + + R A + T W
Sbjct: 310 NSKGRDTVQGRIIVQ--------AQPEWLKVISDTEADIGSNLRWGCAAAGKPRPTVRWL 361
Query: 349 LGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVTGKAYAPEFYY 408
+ L + + LS E+ G+Y C N+ G S + +A AP+F
Sbjct: 362 RNGEPLASQNRVEVLAGDLRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDF-- 419
Query: 409 DTYNPV 414
NPV
Sbjct: 420 -RLNPV 424
Score = 47.4 bits (111), Expect = 5e-05
Identities = 41/133 (30%), Positives = 61/133 (45%), Gaps = 10/133 (7%)
Query: 59 TVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNII-VRALKKGRFWITPDPYHKD 117
TV GTL I I+ D G Y+C A N +G ST I+ VR K IT P D
Sbjct: 466 TVTPDGTLIIRNISRSDEGKYTCFAENFMGKA--NSTGILSVRDATK----ITLAPSSAD 519
Query: 118 DNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIID 177
I +G + + C P+ +LTF+W + P+ ++ +V +L I++
Sbjct: 520 --INLGDNLTLQCHASHDPTMDLTFTWTLDDFPI-DFDKPGGHYRRTNVKETIGDLTILN 576
Query: 178 LKFTDFGTYTCVA 190
+ G YTC+A
Sbjct: 577 AQLRHGGKYTCMA 589
>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
Length = 4391
Score = 100 bits (250), Expect = 4e-21
Identities = 106/413 (25%), Positives = 172/413 (41%), Gaps = 58/413 (14%)
Query: 10 TASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRS-FGTLPEKTVLNGGTLTI 68
T S + + + V PG+ C TG P P+L W G LP K ++GG L +
Sbjct: 1862 TLSAPVVSIHPPQLTVQPGQLAEFRCSATGS-PTPTLEWTGGPGGQLPAKAQIHGGILRL 1920
Query: 69 PAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKI 128
PA+ D Y C A+++ G ++ + V R ++P+ + GR V++
Sbjct: 1921 PAVEPTDQAQYLCRAHSSAGQQVARAV-LHVHGGGGPRVQVSPE----RTQVHAGRTVRL 1975
Query: 129 SCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTC 188
C+ VPS T +W K G L R T + P T D G Y C
Sbjct: 1976 YCRAAGVPS--ATITWRKEGGSLPPQARSERTDIATLLIPAITT--------ADAGFYLC 2025
Query: 189 VA-SLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIIL 247
VA S G + I + V +S PP + + + SP VT EG T++L C V G +
Sbjct: 2026 VATSPAGTAQARIQVVVLSASDASPPPVKI-ESSSPSVT-EGQTLDLNCVVAGSAHAQVT 2083
Query: 248 WSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIV 307
W R + ++P + + LR+ VS SG Y C+ +G P+EA + + V
Sbjct: 2084 WYR--RGGSLPP---HTQVHGSRLRLPQVSPADSGEYVCRVENGSG----PKEASITVSV 2134
Query: 308 QY----------------PPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGN 351
+ P +EP+ + +GQ ++ ++C V +V ++
Sbjct: 2135 LHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQ--TLDLNCVVPGQAHAQVTWHK----- 2187
Query: 352 KLLRTGQFDSQEYTEYAVKSL---SNENYGVYNCSIINEAGAGRCSFLVTGKA 401
R G ++ T ++ L + + G Y C ++ +G S LVT +A
Sbjct: 2188 ---RGGSLPARHQTHGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEA 2237
Score = 86.3 bits (212), Expect = 9e-17
Identities = 98/397 (24%), Positives = 161/397 (40%), Gaps = 52/397 (13%)
Query: 7 SNKTASPSIKLLVDDPI-VVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVL--NG 63
S + SP I +D P V G+ + C+ G SL W L + + NG
Sbjct: 3016 SYRLRSPVIS--IDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDNVHISPNG 3073
Query: 64 GTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRA------LKKGRFWITPDPYHKD 117
+TI + GTY C+A+N G A+ N+ V L +G W+
Sbjct: 3074 SIITIVGTRPSNHGTYRCVASNAYG-VAQSVVNLSVHGPPTVSVLPEGPVWV-------- 3124
Query: 118 DNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIID 177
++G+ V + C P ++ SS + Q + L I
Sbjct: 3125 ---KVGKAVTLECVSAGEPRSSARWTRI-------SSTPAKLEQRTYGLMDSHAVLQISS 3174
Query: 178 LKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLT-VPQEKSPLVTREGDTIELQC 236
K +D GTY C+A G + ++V + + + P V E++ L G T L+C
Sbjct: 3175 AKPSDAGTYVCLAQ-NALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRC 3233
Query: 237 QVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNV 296
TG P P I WS+ + Q TL I V+++ SG Y C + G
Sbjct: 3234 SATGSPAPTIHWSKLRSPL-----PWQHRLEGDTLIIPRVAQQDSGQYICNATSPAGH-- 3286
Query: 297 KPREALVQLIVQYPP--AVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEW-RLGNKL 353
EA + L V+ PP P ++ G+ +V + C A+ LT++W R+G+ L
Sbjct: 3287 --AEATIILHVESPPYATTVPEHASVQAGE--TVQLQC---LAHGTPPLTFQWSRVGSSL 3339
Query: 354 LRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGA 390
G+ ++ + ++ + E+ G Y C + N+ G+
Sbjct: 3340 --PGRATARNELLHFERA-APEDSGRYRCRVTNKVGS 3373
Score = 81.3 bits (199), Expect = 3e-15
Identities = 92/402 (22%), Positives = 167/402 (41%), Gaps = 59/402 (14%)
Query: 28 GEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLNGGTLTIPAITSDDAGTYSCIANNNV 87
G + L C+ P ++TW + G+LP + + G L IP +T D+G Y C +N
Sbjct: 2548 GHTLDLNCLVASQAPH-TITWYKRGGSLPSRHQIVGSRLRIPQVTPADSGEYVCHVSNGA 2606
Query: 88 GNPAKKSTNIIVRALKKGRFWI--TPDPYHKDDN---IQIGREVKISCQVEAVPSEELTF 142
G+ + T++IV G + P + + + G+ + ++C V P +T
Sbjct: 2607 GS---RETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAIIT- 2662
Query: 143 SWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISI 202
W+K G L S + ++L + + D G Y C A+ + + SI
Sbjct: 2663 -WYKRGGSLPSRHQ-----------THGSHLRLHQMSVADSGEYVCRANNNIDAL-EASI 2709
Query: 203 DVNISSSTVPP-----NLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAM 257
+++S S P ++ + E S EG+T++L C V G+ + W + + ++
Sbjct: 2710 VISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHK--RGGSL 2767
Query: 258 PDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQY-------- 309
P ++ LR+ +VS SG Y C+ +G P EA V + ++
Sbjct: 2768 PS---HHQTRGSRLRLHHVSPADSGEYVCRVMGSSG----PLEASVLVTIEASGSSAVHV 2820
Query: 310 -------PPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQ 362
P +EP+ + +GQ ++ + C V+ +T+ R GN R
Sbjct: 2821 PAPGGAPPIRIEPSSSRVAEGQ--TLDLKC-VVPGQAHAQVTWHKRGGNLPAR----HQV 2873
Query: 363 EYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVTGKAYAP 404
+ +S + G Y+C + +G S LVT + +P
Sbjct: 2874 HGPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSP 2915
Score = 80.9 bits (198), Expect = 4e-15
Identities = 98/397 (24%), Positives = 155/397 (39%), Gaps = 61/397 (15%)
Query: 23 IVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLNGGTLTIPAITSDDAGTYSCI 82
+ V G TL C TG PAP++ W + LP + L G TL IP + D+G Y C
Sbjct: 3221 LTVEAGHTATLRCSATGS-PAPTIHWSKLRSPLPWQHRLEGDTLIIPRVAQQDSGQYIC- 3278
Query: 83 ANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTF 142
N +PA + I+ ++ + T P H ++Q G V++ C P LTF
Sbjct: 3279 ---NATSPAGHAEATIILHVESPPY-ATTVPEHA--SVQAGETVQLQCLAHGTP--PLTF 3330
Query: 143 SWFK-----NGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGI 197
W + GR +E + + P+ D G Y C + K G
Sbjct: 3331 QWSRVGSSLPGRATARNELLHFERAAPE----------------DSGRYRCRVTNKVGSA 3374
Query: 198 SDISIDV------NISSSTVPPNLTVPQEKSPLVTRE--GDTIELQCQVTGKPKPIILWS 249
+ + ++ ++++P T + +P + + G ++E C V + W
Sbjct: 3375 EAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWF 3434
Query: 250 RADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQY 309
+ ++ P S+Q DG LRI N+ + G Y CQ G +A QL++Q
Sbjct: 3435 KEGGQLP-PGHSVQ----DGVLRIQNLDQSCQGTYICQAHGPWG----KAQASAQLVIQA 3485
Query: 310 PPAVEPAFLEIRQGQD-----RSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEY 364
P+V + IR +V C L +V W LR G S
Sbjct: 3486 LPSV---LINIRTSVQTVVVGHAVEFECLALGDPKPQV---TWSKVGGHLRPGIVQSGGV 3539
Query: 365 TEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVTGKA 401
A L++ G Y C+ N AG + L+ +A
Sbjct: 3540 VRIAHVELADA--GQYRCTATNAAGTTQSHVLLLVQA 3574
Score = 78.2 bits (191), Expect = 3e-14
Identities = 105/444 (23%), Positives = 173/444 (38%), Gaps = 50/444 (11%)
Query: 12 SPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLNGGTLTIPAI 71
SP V + V GE + L C+ G P + W R +LP + L
Sbjct: 3297 SPPYATTVPEHASVQAGETVQLQCLAHGTPPL-TFQWSRVGSSLPGRATARNELLHFERA 3355
Query: 72 TSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVK---I 128
+D+G Y C N VG+ A+ ++V+ G T P +Q+ +++ I
Sbjct: 3356 APEDSGRYRCRVTNKVGS-AEAFAQLLVQG-PPGSLPATSIPAGSTPTVQVTPQLETKSI 3413
Query: 129 SCQVE---AVPSEELT-FSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFG 184
VE AVPS+ T WFK G L V G + +D G
Sbjct: 3414 GASVEFHCAVPSDRGTQLRWFKEGGQLPPGH---------SVQDGVLRIQNLDQSCQ--G 3462
Query: 185 TYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKP 244
TY C A G + S + I + P++ + S G +E +C G PKP
Sbjct: 3463 TYICQAHGPWGK-AQASAQLVIQAL---PSVLINIRTSVQTVVVGHAVEFECLALGDPKP 3518
Query: 245 IILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQ 304
+ WS+ + G +Q G +RI +V +G YRC + G ++ V
Sbjct: 3519 QVTWSKVGGHLR--PGIVQS---GGVVRIAHVELADAGQYRCTATNAAG----TTQSHVL 3569
Query: 305 LIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQ-E 363
L+VQ P + E+R + C + YP +++ +KL + DS+ E
Sbjct: 3570 LLVQALPQISMP-QEVRVPAGSAAVFPC-IASGYPTPDISW-----SKLDGSLPPDSRLE 3622
Query: 364 YTEYAVKSLSNENYGVYNCSIINEAGAGRC-SFLVTGKAYAPEFYYDTYN----PVWQNR 418
+ S+ ++ G Y C+ N G + + L + P F Y+ P ++
Sbjct: 3623 NNMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQVPERVVPYFTQTPYSFLPLPTIKDA 3682
Query: 419 HRVYSYSLQWTQMNPDAVDRIVAY 442
+R + + + PD+ D ++ Y
Sbjct: 3683 YRKFEIKITF---RPDSADGMLLY 3703
Score = 75.1 bits (183), Expect = 2e-13
Identities = 94/401 (23%), Positives = 167/401 (41%), Gaps = 60/401 (14%)
Query: 25 VNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLNGGTLTIPAITSDDAGTYSCIAN 84
V G+ + L C+ G A +TW + G+LP + ++G L + +T D+G Y C
Sbjct: 2448 VAEGQTLDLNCLVAGQAHA-QVTWHKRGGSLPARHQVHGSRLRLLQVTPADSGEYVCRVV 2506
Query: 85 NNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDD---NIQIGREVKISCQVEAVPSEELT 141
+ G I + L P + ++ G + ++C V + T
Sbjct: 2507 GSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPH--T 2564
Query: 142 FSWFKNGRPLRSSERMVITQTD-PDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDI 200
+W+K G L S ++V ++ P V+P D G Y C S G G +
Sbjct: 2565 ITWYKRGGSLPSRHQIVGSRLRIPQVTP------------ADSGEYVCHVS-NGAGSRET 2611
Query: 201 SIDVNI--SSSTVPPNLTVP---QEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEV 255
S+ V I S S+ P+++ P + SP V EG T++L C V +P+ II W + +
Sbjct: 2612 SLIVTIQGSGSSHVPSVSPPIRIESSSPTVV-EGQTLDLNCVVARQPQAIITWYK--RGG 2668
Query: 256 AMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIV-------- 307
++P + +++ LR+ +S SG Y C+ + N+ EA + + V
Sbjct: 2669 SLPS---RHQTHGSHLRLHQMSVADSGEYVCRANN----NIDALEASIVISVSPSAGSPS 2721
Query: 308 ----QYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQE 363
P +E + + +G+ ++ ++C V +V ++ R G S
Sbjct: 2722 APGSSMPIRIESSSSHVAEGE--TLDLNCVVPGQAHAQVTWHK--------RGGSLPSHH 2771
Query: 364 YT---EYAVKSLSNENYGVYNCSIINEAGAGRCSFLVTGKA 401
T + +S + G Y C ++ +G S LVT +A
Sbjct: 2772 QTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEA 2812
Score = 75.1 bits (183), Expect = 2e-13
Identities = 71/318 (22%), Positives = 131/318 (41%), Gaps = 30/318 (9%)
Query: 25 VNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLNGGTLTIPAITSDDAGTYSCIAN 84
V G+ + L CV G A +TW + G+LP + +G L + ++ D+G Y C A
Sbjct: 2936 VTEGQTLDLNCVVPGQAHA-QVTWYKRGGSLPARHQTHGSQLRLHLVSPADSGEYVCRAA 2994
Query: 85 NNVGNPAKKSTNIIVRALKKGRF-----WITPDPYHKDDNIQIGREVKISCQVE--AVPS 137
+ G + S + V + + I+ DP +Q G++ C + A P
Sbjct: 2995 SGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDP--PSSTVQQGQDASFKCLIHDGAAP- 3051
Query: 138 EELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGI 197
++ W + L + + +SP + + I+ + ++ GTY CVAS G+
Sbjct: 3052 --ISLEWKTRNQEL---------EDNVHISPNGSIITIVGTRPSNHGTYRCVAS-NAYGV 3099
Query: 198 SDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVA- 256
+ +++++ PP ++V E P+ + G + L+C G+P+ W+R A
Sbjct: 3100 AQSVVNLSVHG---PPTVSVLPE-GPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAK 3155
Query: 257 MPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYP--PAVE 314
+ + + L+I + +G Y C G K E +V P P V+
Sbjct: 3156 LEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQ 3215
Query: 315 PAFLEIRQGQDRSVTMSC 332
E+ + T+ C
Sbjct: 3216 AEEAELTVEAGHTATLRC 3233
Score = 73.6 bits (179), Expect = 6e-13
Identities = 96/415 (23%), Positives = 162/415 (39%), Gaps = 59/415 (14%)
Query: 7 SNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLNGGTL 66
++ + P +K+ P V G+ + L CV G A +TW R G+LP T ++G L
Sbjct: 2045 ASDASPPPVKIESSSPSVTE-GQTLDLNCVVAGSAHA-QVTWYRRGGSLPPHTQVHGSRL 2102
Query: 67 TIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDP--------YHKDD 118
+P ++ D+G Y C N G T ++ G + TP P
Sbjct: 2103 RLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSY-TPVPGSTRPIRIEPSSS 2161
Query: 119 NIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDL 178
++ G+ + ++C V ++T W K G L + QT + L + +
Sbjct: 2162 HVAEGQTLDLNCVVPGQAHAQVT--WHKRGGSLPARH-----QTHGSL------LRLHQV 2208
Query: 179 KFTDFGTYTCVASLKGGGISDISIDVNISSSTVP-PNLTVPQEKSPLVTREGDTIELQCQ 237
D G Y C G + + S+ V I +S +P P V E S EG T++L C
Sbjct: 2209 TPADSGEYVCHVVGTSGPL-EASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCV 2267
Query: 238 VTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVK 297
V G+ + W + + + + L I S +G Y C+ S NG
Sbjct: 2268 VAGQAHAQVTWYKRGGSL-----PARHQVRGSRLYIFQASPADAGQYVCRAS--NGM--- 2317
Query: 298 PREALVQLIV--------------QYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVL 343
EA + + V P +EP+ ++ +GQ ++ ++C V+ +
Sbjct: 2318 --EASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQ--TLDLNC-VVPGQSHAQV 2372
Query: 344 TYEWRLGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVT 398
T+ R G+ +R S + S + G Y C ++ + S LVT
Sbjct: 2373 TWHKRGGSLPVRHQTHGSL----LRLYQASPADSGEYVCRVLGSSVPLEASVLVT 2423
Score = 69.3 bits (168), Expect = 1e-11
Identities = 95/410 (23%), Positives = 157/410 (38%), Gaps = 69/410 (16%)
Query: 25 VNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLNGGTLTIPAITSDDAGTYSCIAN 84
V G+ + L CV G A +TW + G+LP + + G L I + DAG Y C A+
Sbjct: 2256 VAEGQTLDLSCVVAGQAHA-QVTWYKRGGSLPARHQVRGSRLYIFQASPADAGQYVCRAS 2314
Query: 85 NN------VGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSE 138
N V + N+ A I P + G+ + ++C V
Sbjct: 2315 NGMEASITVTVTGTQGANLAYPAGSTQPIRIEPS----SSQVAEGQTLDLNCVVPGQSHA 2370
Query: 139 ELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGIS 198
++T W K G L V QT + L + D G Y C + G +
Sbjct: 2371 QVT--WHKRGGSLP-----VRHQTHGSL------LRLYQASPADSGEYVC--RVLGSSVP 2415
Query: 199 -DISIDVNISSSTVPPNL----TVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADK 253
+ S+ V I + P L TV E S EG T++L C V G+ + W +
Sbjct: 2416 LEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGG 2475
Query: 254 EVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQ----- 308
+ + + + LR++ V+ SG Y C+ +G +EA V + +Q
Sbjct: 2476 SL-----PARHQVHGSRLRLLQVTPADSGEYVCRVVGSSG----TQEASVLVTIQQRLSG 2526
Query: 309 -------YPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDS 361
YP +E + + G ++ ++C V P + Y+ R G S
Sbjct: 2527 SHSQGVAYPVRIESSSASLANG--HTLDLNCLVASQAPHTITWYK--------RGGSLPS 2576
Query: 362 QEY---TEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVT----GKAYAP 404
+ + + ++ + G Y C + N AG+ S +VT G ++ P
Sbjct: 2577 RHQIVGSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVP 2626
Score = 67.8 bits (164), Expect = 3e-11
Identities = 93/393 (23%), Positives = 149/393 (37%), Gaps = 54/393 (13%)
Query: 25 VNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLNGGTLTIPAITSDDAGTYSCIAN 84
V GE + L CV G A +TW + G+LP G L + ++ D+G Y C
Sbjct: 2738 VAEGETLDLNCVVPGQAHA-QVTWHKRGGSLPSHHQTRGSRLRLHHVSPADSGEYVCRVM 2796
Query: 85 NNVGNPAKKSTNIIVRALKKGRFWITPDP--------YHKDDNIQIGREVKISCQVEAVP 136
+ G P + S + + A + P P + G+ + + C V
Sbjct: 2797 GSSG-PLEASVLVTIEASGSSAVHV-PAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQA 2854
Query: 137 SEELTFSWFKNGR--PLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKG 194
++T W K G P R + + + VSP D G Y+C +
Sbjct: 2855 HAQVT--WHKRGGNLPARHQVHGPLLRLN-QVSPA------------DSGEYSCQVTGSS 2899
Query: 195 GGISDISIDVNISSST---VP-PNLTVPQ--EKSPLVTREGDTIELQCQVTGKPKPIILW 248
G + + S+ V I S+ +P P L P E S EG T++L C V G+ + W
Sbjct: 2900 GTL-EASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTW 2958
Query: 249 SRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNG--------FNVKPRE 300
+ + + +++ LR+ VS SG Y C+ + G V P E
Sbjct: 2959 YKRGGSL-----PARHQTHGSQLRLHLVSPADSGEYVCRAASGPGPEQEASFTVTVPPSE 3013
Query: 301 ALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVL-RAYPIRVLTYEWRLGNKLLRTGQF 359
+ +++P ++QGQD S C + A PI + EW+ N+ L
Sbjct: 3014 GSSYRLRSPVISIDPPSSTVQQGQDAS--FKCLIHDGAAPI---SLEWKTRNQELEDNVH 3068
Query: 360 DSQEYTEYAVKSLSNENYGVYNCSIINEAGAGR 392
S + + N+G Y C N G +
Sbjct: 3069 ISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQ 3101
Score = 66.2 bits (160), Expect = 1e-10
Identities = 91/398 (22%), Positives = 152/398 (38%), Gaps = 52/398 (13%)
Query: 25 VNPGEAITLVCVTTGGEPAPSLTWVRSF-GTLPEKTVLNGGTLTIPAITSDDAGTYSCIA 83
V PG +T +C PA +L W R G LP + + G LTI + DAGTY C
Sbjct: 1783 VRPGADVTFICTAKSKSPAYTLVWTRLHNGKLPTRAMDFNGILTIRNVQLSDAGTYVCTG 1842
Query: 84 NNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDD-NIQIGREVKISCQVEAVPSEELTF 142
+N +T + G H +Q G+ + C P+ L +
Sbjct: 1843 SNMFAMDQGTAT---LHVQASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEW 1899
Query: 143 SWFKNGR-PLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVA-SLKGGGISDI 200
+ G+ P ++ I + P V P TD Y C A S G ++
Sbjct: 1900 TGGPGGQLPAKAQIHGGILRL-PAVEP------------TDQAQYLCRAHSSAGQQVARA 1946
Query: 201 SIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDG 260
+ V+ P + V E++ + G T+ L C+ G P I W + + ++P
Sbjct: 1947 VLHVHGGGG---PRVQVSPERTQV--HAGRTVRLYCRAAGVPSATITWRK--EGGSLPPQ 1999
Query: 261 SMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIV-------QYPPAV 313
+ + TL I ++ +G Y C + G +A +Q++V P +
Sbjct: 2000 ARSERTDIATLLIPAITTADAGFYLCVATSPAG----TAQARIQVVVLSASDASPPPVKI 2055
Query: 314 EPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAVKSLS 373
E + + +GQ ++ ++C V + +V Y R G L Q + + +S
Sbjct: 2056 ESSSPSVTEGQ--TLDLNCVVAGSAHAQVTWY--RRGGSLPPHTQVHG---SRLRLPQVS 2108
Query: 374 NENYGVYNCSIINEAGAGRCSFLV-------TGKAYAP 404
+ G Y C + N +G S V +G +Y P
Sbjct: 2109 PADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTP 2146
Score = 63.2 bits (152), Expect = 8e-10
Identities = 83/385 (21%), Positives = 150/385 (38%), Gaps = 42/385 (10%)
Query: 24 VVNPGEAITLVCVTTGGEPAPSLTWVRSFGT-LPEKTVLN--GGTLTIPAITSDDAGTYS 80
+V G + +L C +G P W R G +P T G L P++ DAG Y
Sbjct: 1687 IVPQGGSHSLRCQVSGSPPH-YFYWSREDGRPVPSGTQQRHQGSELHFPSVQPSDAGVYI 1745
Query: 81 CIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEA-VPSEE 139
C N + ++ ++ A K +T + + +++ G +V C ++ P+
Sbjct: 1746 CTCRNLHQSNTSRAELLVTEAPSK-PITVTVEE-QRSQSVRPGADVTFICTAKSKSPAYT 1803
Query: 140 LTFSWFKNGR-PLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVAS---LKGG 195
L ++ NG+ P R+ + I L I +++ +D GTY C S
Sbjct: 1804 LVWTRLHNGKLPTRAMDFNGI-------------LTIRNVQLSDAGTYVCTGSNMFAMDQ 1850
Query: 196 GISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEV 255
G + + + + + S ++ PQ L + G E +C TG P P + W+
Sbjct: 1851 GTATLHVQASGTLSAPVVSIHPPQ----LTVQPGQLAEFRCSATGSPTPTLEWTGG---- 1902
Query: 256 AMPDGSM--QMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAV 313
P G + + + + G LR+ V Y C+ G V A++ + P V
Sbjct: 1903 --PGGQLPAKAQIHGGILRLPAVEPTDQAQYLCRAHSSAGQQV--ARAVLHVHGGGGPRV 1958
Query: 314 EPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRL-GNKLLRTGQFDSQEYTEYAVKSL 372
+ + + R+V + C RA + T WR G L + + + + ++
Sbjct: 1959 QVSPERTQVHAGRTVRLYC---RAAGVPSATITWRKEGGSLPPQARSERTDIATLLIPAI 2015
Query: 373 SNENYGVYNCSIINEAGAGRCSFLV 397
+ + G Y C + AG + V
Sbjct: 2016 TTADAGFYLCVATSPAGTAQARIQV 2040
Score = 44.3 bits (103), Expect = 4e-04
Identities = 45/172 (26%), Positives = 65/172 (37%), Gaps = 10/172 (5%)
Query: 215 LTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIV 274
L V + + +G + L+CQV+G P WSR D +P G+ Q L
Sbjct: 1677 LVVEVHPARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGR-PVPSGTQQRHQ-GSELHFP 1734
Query: 275 NVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAV---EPAFLEIRQGQDRSVTMS 331
+V +G+Y C + N E LV P V E +R G D VT
Sbjct: 1735 SVQPSDAGVYICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGAD--VTFI 1792
Query: 332 CRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCS 383
C P L + RL N L T D ++++ + G Y C+
Sbjct: 1793 CTAKSKSPAYTLVWT-RLHNGKLPTRAMDFNGI--LTIRNVQLSDAGTYVCT 1841
Score = 42.4 bits (98), Expect = 0.002
Identities = 29/108 (26%), Positives = 46/108 (42%), Gaps = 2/108 (1%)
Query: 211 VPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEV-AMPDGSMQMESYDG 269
+PP + P +S +R G T+ C G P PII W + + P ++ E G
Sbjct: 404 MPPQVVTPPRESIQASR-GQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRG 462
Query: 270 TLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAF 317
TL I +V G Y C+ G + +++L+ Q P + F
Sbjct: 463 TLIIRDVKESDQGAYTCEAMNARGMVFGIPDGVLELVPQRGPCPDGHF 510
Score = 37.4 bits (85), Expect = 0.050
Identities = 24/74 (32%), Positives = 35/74 (47%), Gaps = 7/74 (9%)
Query: 21 DPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEK---TVLNGG---TLTIPAITSD 74
+ I + G+ +T CV G P P + W ++G +P TV + G TL I +
Sbjct: 414 ESIQASRGQTVTFTCVAIG-VPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKES 472
Query: 75 DAGTYSCIANNNVG 88
D G Y+C A N G
Sbjct: 473 DQGAYTCEAMNARG 486
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 100 bits (250), Expect = 4e-21
Identities = 105/397 (26%), Positives = 162/397 (40%), Gaps = 53/397 (13%)
Query: 10 TASPSIKLLVDDPIVVNP---------GEAITLVCVTTGGEPAPSLTW------VRSFGT 54
+A + L V +P V+ P I L C TG P+P +TW V + G
Sbjct: 3975 SAHRHVTLHVHEPPVIQPQPSELHVILNNPILLPCEATG-TPSPFITWQKEGINVNTSGR 4033
Query: 55 LPEKTVLNGGTLTIPAITSDDAGTYSCIANNNVGNP-AKKSTNIIVRALKKGRFWITPDP 113
VL G L I +DAGTY C+A N G K N+ V + P
Sbjct: 4034 --NHAVLPSGGLQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPV--------ISP 4083
Query: 114 YHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNL 173
+ K+ I + + + +SC+ + +P ++T W K+GR + S R + + +L
Sbjct: 4084 HLKEYVIAVDKPITLSCEADGLPPPDIT--WHKDGRAIVESIRQRVLSSG--------SL 4133
Query: 174 DIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIE 233
I ++ D G YTC+A+ G S S + + VPP + + E
Sbjct: 4134 QIAFVQPGDAGHYTCMAA-NVAGSSSTSTKLTVH---VPPR--IRSTEGHYTVNENSQAI 4187
Query: 234 LQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNG 293
L C G P P I W + + +A G E Y G L + NV E SG Y C + G
Sbjct: 4188 LPCVADGIPTPAINWKKDNVLLANLLGKYTAEPY-GELILENVVLEDSGFYTCVANNAAG 4246
Query: 294 FNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKL 353
+ V L V P ++ + + +SC+ P+ LT W N +
Sbjct: 4247 EDTH----TVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKA-TGIPLPKLT--WTFNNNI 4299
Query: 354 LRTGQFDS-QEYTEYAVKSLSNENYGVYNCSIINEAG 389
+ FDS ++E ++ +S E+ G Y C+ N G
Sbjct: 4300 I-PAHFDSVNGHSELVIERVSKEDSGTYVCTAENSVG 4335
Score = 100 bits (248), Expect = 6e-21
Identities = 102/381 (26%), Positives = 177/381 (46%), Gaps = 48/381 (12%)
Query: 23 IVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKT----VLNGGT-LTIPAITSDDAG 77
+V NP + L C G PAPSLTW++ + + VL+GG L + + D G
Sbjct: 2024 VVNNP---VRLECEARG-IPAPSLTWLKDGSPVSSFSNGLQVLSGGRILALTSAQISDTG 2079
Query: 78 TYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQ--IGREVKISCQVEAV 135
Y+C+A N G +K +I +R ++ P+ ++ N+ I + V++ CQ +A+
Sbjct: 2080 RYTCVAVNAAG---EKQRDIDLRV------YVPPNIMGEEQNVSVLISQAVELLCQSDAI 2130
Query: 136 PSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGG 195
P LT W K+G PL + +S + L I D + D G YTC A+
Sbjct: 2131 PPPTLT--WLKDGHPLLKKPGL-------SISENRSVLKIEDAQVQDTGRYTCEAT-NVA 2180
Query: 196 GISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEV 255
G ++ + +VNI VPPN+ E + L EG+ I L C+ +G P P ++W + V
Sbjct: 2181 GKTEKNYNVNI---WVPPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPV 2237
Query: 256 AMPD-GSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAV- 313
G +++ S L+I + + +Y C S G +E +Q+ ++ P +
Sbjct: 2238 LTDSMGRVRILSGGRQLQISIAEKSDAALYSCVASNVAG--TAKKEYNLQVYIR--PTIT 2293
Query: 314 ----EPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRT-GQFDSQEYTEYA 368
P + + +G +S+++ C V + P +T+ + G+ L++ G E
Sbjct: 2294 NSGSHPTEIIVTRG--KSISLECEV-QGIPPPTVTW-MKDGHPLIKAKGVEILDEGHILQ 2349
Query: 369 VKSLSNENYGVYNCSIINEAG 389
+K++ + G Y C +N AG
Sbjct: 2350 LKNIHVSDTGRYVCVAVNVAG 2370
Score = 97.1 bits (240), Expect = 5e-20
Identities = 95/378 (25%), Positives = 162/378 (42%), Gaps = 33/378 (8%)
Query: 21 DPIVVNPGEAITLVCVTTGGEPAPSLTWVRS---FGTLPEKTV-LNGGTLTIPAITSDDA 76
+ I V G + ++ C+T G PAPS+ W+R G TV +G L + ++D+
Sbjct: 3443 EEITVLKGSSTSMACITDG-TPAPSMAWLRDGQPLGLDAHLTVSTHGMVLQLLKAETEDS 3501
Query: 77 GTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVP 136
G Y+CIA+N G +K + I++ L+ I H++ ++ + ++++C +P
Sbjct: 3502 GKYTCIASNEAGEVSK---HFILKVLEPPH--INGSEEHEEISVIVNNPLELTCIASGIP 3556
Query: 137 SEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGG 196
+ ++T W K+GRPL ++++ G L I + D G YTC+AS G
Sbjct: 3557 APKMT--WMKDGRPLPQTDQV-------QTLGGGEVLRISTAQVEDTGRYTCLASSPAGD 3607
Query: 197 ISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVA 256
D V + VPPN+ E + + L+C+ P P+I W R + E
Sbjct: 3608 -DDKEYLVRVH---VPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLR-NGERL 3662
Query: 257 MPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPA 316
+++ S L+I N + Y C S G RE + L V PP ++
Sbjct: 3663 QATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKTT--REFI--LTVNVPPNIKGG 3718
Query: 317 FLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLL--RTGQFDSQEYTEYAVKSLSN 374
+ ++S + C + P +T WR +L ++ E ++S
Sbjct: 3719 PQSLVILLNKSTVLEC-IAEGVPTPRIT--WRKDGAVLAGNHARYSILENGFLHIQSAHV 3775
Query: 375 ENYGVYNCSIINEAGAGR 392
+ G Y C N AG R
Sbjct: 3776 TDTGRYLCMATNAAGTDR 3793
Score = 91.7 bits (226), Expect = 2e-18
Identities = 91/312 (29%), Positives = 137/312 (43%), Gaps = 53/312 (16%)
Query: 3 SFRLSNKTASPSIKLLVDD----PIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEK 58
SF L N SP+I + D + V +LVC PA ++TW + GT E
Sbjct: 2562 SFSL-NVFVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPA-TITWFKD-GTPLES 2618
Query: 59 T----VLNGG-TLTIPAITSDDAGTYSCIANNNVGNPAK--KSTNIIVRALKKGRFWITP 111
+L GG TL I D+AG YSC+A N G K + I + KG W P
Sbjct: 2619 NRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLW-GP 2677
Query: 112 DPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTT 171
K+ I++ + + C+ A+PS L SW+K+G+PL+S + + +++
Sbjct: 2678 GLSPKEVKIKVNNTLTLECEAYAIPSASL--SWYKDGQPLKSDDHV-------NIAANGH 2728
Query: 172 NLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVT--REG 229
L I + + +D G YTCVAS G ++ DVNI VPP+ E ++ R G
Sbjct: 2729 TLQIKEAQISDTGRYTCVAS-NIAGEDELDFDVNIQ---VPPSFQKLWEIGNMLDTGRNG 2784
Query: 230 DT--------IELQCQVTGKPKPIILW-------SRADKEVAMPDGSMQMESYDGTLRIV 274
+ I L C+ P P + W + +DK + +P G + L+I
Sbjct: 2785 EAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGGRV--------LQIP 2836
Query: 275 NVSREMSGMYRC 286
E +G Y C
Sbjct: 2837 RAKVEDAGRYTC 2848
Score = 91.7 bits (226), Expect = 2e-18
Identities = 97/381 (25%), Positives = 165/381 (43%), Gaps = 43/381 (11%)
Query: 21 DPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKT---VLNGG-TLTIPAITSDDA 76
D I+ NP I+L C T P P+LTW + L +L GG L IP +DA
Sbjct: 2788 DVIINNP---ISLYCETNAAPP-PTLTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDA 2843
Query: 77 GTYSCIANNNVGNPA-KKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAV 135
G Y+C+A N G + + ++V + KG P+ + + + + I C
Sbjct: 2844 GRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPE----EVTVLVNKSALIECLSSGS 2899
Query: 136 PSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGG 195
P+ SW K+G+PL + +S G L I++ + TD G Y CVA G
Sbjct: 2900 PAPR--NSWQKDGQPLLEDDHHKF------LSNGRI-LQILNTQITDIGRYVCVAENTAG 2950
Query: 196 GISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEV 255
++N+ VPP++ P+ ++ L + I L C+V+G P P + W + ++ +
Sbjct: 2951 SAKKY-FNLNVH---VPPSVIGPKSEN-LTVVVNNFISLTCEVSGFPPPDLSWLKNEQPI 3005
Query: 256 AMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEP 315
+ ++ + TL+I+ G Y C G + K L V PP+++
Sbjct: 3006 KLNTNTLIVPG-GRTLQIIRAKVSDGGEYTCIAINQAGESKKK----FSLTVYVPPSIKD 3060
Query: 316 ------AFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFD-SQEYTEYA 368
+ + +R+G SV++ C A P V+T+ ++ G + + + +
Sbjct: 3061 HDSESLSVVNVREG--TSVSLECE-SNAVPPPVITW-YKNGRMITESTHVEILADGQMLH 3116
Query: 369 VKSLSNENYGVYNCSIINEAG 389
+K + G Y C IN AG
Sbjct: 3117 IKKAEVSDTGQYVCRAINVAG 3137
Score = 91.3 bits (225), Expect = 3e-18
Identities = 90/370 (24%), Positives = 162/370 (43%), Gaps = 40/370 (10%)
Query: 40 GEPAPSLTWVRS----FGTLPEKTVLNGGTL-TIPAITSDDAGTYSCIANNNVGNPAKK- 93
G P P++ W+ + G P ++L GTL I ++T D G Y C+A N G +K
Sbjct: 1292 GTPKPTIKWLHNGRELTGREPGISILEDGTLLVIASVTPYDNGEYICVAVNEAGTTERKY 1351
Query: 94 STNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRS 153
+ + V + K + +T + ++ + + + C+VE PS + W+K+ +
Sbjct: 1352 NLKVHVPPVIKDKEQVT------NVSVLLNQLTNLFCEVEGTPSPIIM--WYKDNVQVTE 1403
Query: 154 SERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVA-SLKGGGISDISIDVNISSSTVP 212
S T V+ G L + D G Y+C A ++ G +IDV + + +
Sbjct: 1404 SS------TIQTVNNGKI-LKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIG 1456
Query: 213 PNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLR 272
N P E S ++ R+ + L+CQV G P P I W + K + + D ++++ L
Sbjct: 1457 TNF--PNEVSVVLNRD---VALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQVLH 1511
Query: 273 IVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFL--EIRQGQDRSVTM 330
+ N R G Y+C S G K ++L + PP+++ + +I + + +
Sbjct: 1512 LKNARRNDKGRYQCTVSNAAGKQAKD----IKLTIYIPPSIKGGNVTTDISVLINSLIKL 1567
Query: 331 SCRVLRAYPIRVLTYEWRLGNKLLRTGQ---FDSQEYTEYAVKSLSNENYGVYNCSIINE 387
C R P+ +T+ ++ G ++ + Q D +Y +S+ Y C + N
Sbjct: 1568 ECET-RGLPMPAITW-YKDGQPIMSSSQALYIDKGQYLHIPRAQVSDS--ATYTCHVANV 1623
Query: 388 AGAGRCSFLV 397
AG SF V
Sbjct: 1624 AGTAEKSFHV 1633
Score = 89.7 bits (221), Expect = 8e-18
Identities = 78/271 (28%), Positives = 122/271 (45%), Gaps = 37/271 (13%)
Query: 23 IVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEK--TVLNGGTLTIPAITSDDAGTYS 80
+ +N GE + L C TG P P LTW + +P +V L I ++ +D+GTY
Sbjct: 4269 VSLNKGEQLRLSCKATG-IPLPKLTWTFNNNIIPAHFDSVNGHSELVIERVSKEDSGTYV 4327
Query: 81 CIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQ-----IGREVKISCQVEAV 135
C A N+VG V+A+ G ++ P K D +G ++C+V+
Sbjct: 4328 CTAENSVG---------FVKAI--GFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGD 4376
Query: 136 PSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGG 195
P+ T W + G + S R I Q G +L I D G YTCVA+ + G
Sbjct: 4377 PTP--TIQWNRKGVDIEISHR--IRQL------GNGSLAIYGTVNEDAGDYTCVATNEAG 4426
Query: 196 GISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEV 255
+ + S+ + + S PP +T+ E V G I L CQ TG+P+P I WSR +
Sbjct: 4427 -VVERSMSLTLQS---PPIITL--EPVETVINAGGKIILNCQATGEPQPTITWSRQGHSI 4480
Query: 256 AMPDGSMQMESYDGTLRIVNVSREMSGMYRC 286
+ D + + +L I + +E + + C
Sbjct: 4481 SWDDRVNVLS--NNSLYIADAQKEDTSEFEC 4509
Score = 89.0 bits (219), Expect = 1e-17
Identities = 99/389 (25%), Positives = 158/389 (40%), Gaps = 57/389 (14%)
Query: 21 DPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPE----KTVLNGGTLTIPAITSDDA 76
+ + V ++ + C+++G PAP +W + L E K + NG L I D
Sbjct: 2880 EEVTVLVNKSALIECLSSGS-PAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNTQITDI 2938
Query: 77 GTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVP 136
G Y C+A N G+ AKK N+ V P ++ + + + ++C+V P
Sbjct: 2939 GRYVCVAENTAGS-AKKYFNLNVHVPPS-----VIGPKSENLTVVVNNFISLTCEVSGFP 2992
Query: 137 SEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGG 196
+L SW KN +P++ + +I PG L II K +D G YTC+A + G
Sbjct: 2993 PPDL--SWLKNEQPIKLNTNTLIV-------PGGRTLQIIRAKVSDGGEYTCIA-INQAG 3042
Query: 197 ISDISIDVNISSSTVPPNLTVPQEKSPLV--TREGDTIELQCQVTGKPKPIILWSRADKE 254
S + + VPP++ +S V REG ++ L+C+ P P+I W + +
Sbjct: 3043 ESKKKFSLTV---YVPPSIKDHDSESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRM 3099
Query: 255 VA-------MPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIV 307
+ + DG M L I +G Y C+ G + K L V
Sbjct: 3100 ITESTHVEILADGQM--------LHIKKAEVSDTGQYVCRAINVAGRDDKN----FHLNV 3147
Query: 308 QYPPAVE-PAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEY-- 364
PP++E P I + VT++C A I T W +K R DS E
Sbjct: 3148 YVPPSIEGPEREVIVETISNPVTLTC---DATGIPPPTIAWLKNHK--RIENSDSLEVRI 3202
Query: 365 ----TEYAVKSLSNENYGVYNCSIINEAG 389
++ + + + G Y C N G
Sbjct: 3203 LSGGSKLQIARSQHSDSGNYTCIASNMEG 3231
Score = 86.3 bits (212), Expect = 9e-17
Identities = 89/364 (24%), Positives = 155/364 (42%), Gaps = 57/364 (15%)
Query: 5 RLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLP-------- 56
+++ SP + + + + G +TL C G P P++ W R +P
Sbjct: 784 KITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQG-YPEPTIKW-RRLDNMPIFSRPFSV 841
Query: 57 -EKTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYH 115
+ L G L I + + D GTY C A N G + T + V L I+P
Sbjct: 842 SSISQLRTGALFILNLWASDKGTYICEAENQFGK-IQSETTVTVTGLVAPLIGISPSVA- 899
Query: 116 KDDNIQIGREVKISCQVEA---VPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTN 172
N+ G+++ + C + A +P W KN L + + + S G+ +
Sbjct: 900 ---NVIEGQQLTLPCTLLAGNPIPERR----WIKNSAMLLQNPYITVR------SDGSLH 946
Query: 173 LDIIDLKFTDFGTYTCVAS-LKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDT 231
++ + L+ D G YTCVAS + G S+ V++ T+ + L T EG
Sbjct: 947 IERVQLQ--DGGEYTCVASNVAGTNNKTTSVVVHVLP-------TIQHGQQILSTIEGIP 997
Query: 232 IELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQY 291
+ L C+ +G PKP ++WS+ + ++ + DG+L +V+ E SG Y C +
Sbjct: 998 VTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGA-DGSLYVVSPGGEESGEYVCTATNT 1056
Query: 292 NGFNVKPREALVQLIVQYPPAV----------EPAFLEIRQGQDRSVTMSCRVLRAYPIR 341
G+ + VQL V P V +P + + G++ VT+ C V ++ P
Sbjct: 1057 AGY----AKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEE--VTLPCEV-KSLPPP 1109
Query: 342 VLTY 345
++T+
Sbjct: 1110 IITW 1113
Score = 86.3 bits (212), Expect = 9e-17
Identities = 99/391 (25%), Positives = 162/391 (41%), Gaps = 32/391 (8%)
Query: 8 NKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLP-----EKTVLN 62
N PSI+ + IV +TL C TG P P++ W+++ + E +L+
Sbjct: 3146 NVYVPPSIEGPEREVIVETISNPVTLTCDATG-IPPPTIAWLKNHKRIENSDSLEVRILS 3204
Query: 63 GGT-LTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQ 121
GG+ L I D+G Y+CIA+N G A+K + ++ + D ++
Sbjct: 3205 GGSKLQIARSQHSDSGNYTCIASNMEGK-AQKYYFLSIQVPPS----VAGAEIPSDVSVL 3259
Query: 122 IGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFT 181
+G V++ C +P+ + W K+G+P+ S E I VS + L+I +
Sbjct: 3260 LGENVELVCNANGIPTPLI--QWLKDGKPIASGETERIR-----VSANGSTLNIYGALTS 3312
Query: 182 DFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGK 241
D G YTCVA+ G I N++ P E L+T +I ++C+ TG
Sbjct: 3313 DTGKYTCVATNPAGEEDRI---FNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGT 3369
Query: 242 PKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREA 301
P P I W + + + +++ + +RIV +Y C S G + K
Sbjct: 3370 PPPQINWLKNGLPLPL-SSHIRLLAAGQVIRIVRAQVSDVAVYTCVASNRAGVDNKH--- 3425
Query: 302 LVQLIVQYPPAVEPAF--LEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKL-LRTGQ 358
L V PP ++ + EI + S +M+C + P + + R G L L
Sbjct: 3426 -YNLQVFAPPNMDNSMGTEEITVLKGSSTSMAC-ITDGTPAPSMAW-LRDGQPLGLDAHL 3482
Query: 359 FDSQEYTEYAVKSLSNENYGVYNCSIINEAG 389
S + E+ G Y C NEAG
Sbjct: 3483 TVSTHGMVLQLLKAETEDSGKYTCIASNEAG 3513
Score = 85.1 bits (209), Expect = 2e-16
Identities = 97/400 (24%), Positives = 160/400 (40%), Gaps = 51/400 (12%)
Query: 10 TASPSIKLLVDDP--IVVNP-------GEAITLVCVTTGGEPAPSLTWVRSFGTLPEK-- 58
+++ S+ L V +P + V P G ++++C TG P P + W + +
Sbjct: 599 SSAASVFLTVQEPPKVTVMPKNQSFTGGSEVSIMCSATG-YPKPKIAWTVNDMFIVGSHR 657
Query: 59 -TVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKD 117
+ + GTL I DAG Y C+A+N+ G + ST +R ++ + + +
Sbjct: 658 YRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNST---LRYIEAPKLMVV----QSE 710
Query: 118 DNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIID 177
+ +G + C+ +P ++ WFK LR S ++I P L I +
Sbjct: 711 LLVALGDITVMECKTSGIPPPQV--KWFKGDLELRPSTFLII-------DPLLGLLKIQE 761
Query: 178 LKFTDFGTYTCVASLKGG-GISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQC 236
+ D G YTCVA + G I++DV PP QE + + G + L C
Sbjct: 762 TQDLDAGDYTCVAINEAGRATGKITLDVG-----SPP--VFIQEPADVSMEIGSNVTLPC 814
Query: 237 QVTGKPKPIILWSRADKEVAMP------DGSMQMESYDGTLRIVNVSREMSGMYRCQTSQ 290
V G P+P I W R D MP S + G L I+N+ G Y C+
Sbjct: 815 YVQGYPEPTIKWRRLDN---MPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAEN 871
Query: 291 YNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEW-RL 349
G V +V + P+ + +GQ +T+ C +L PI W +
Sbjct: 872 QFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQ--QLTLPCTLLAGNPIP--ERRWIKN 927
Query: 350 GNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAG 389
LL+ + ++ + ++ G Y C N AG
Sbjct: 928 SAMLLQNPYITVRSDGSLHIERVQLQDGGEYTCVASNVAG 967
Score = 84.7 bits (208), Expect = 3e-16
Identities = 102/404 (25%), Positives = 154/404 (38%), Gaps = 54/404 (13%)
Query: 23 IVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPE----KTVLNGGTLTIPAITSDDAGT 78
+ + +TL C P+ SL+W + L NG TL I D G
Sbjct: 2684 VKIKVNNTLTLECEAYA-IPSASLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGR 2742
Query: 79 YSCIANNNVGN------------PAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREV 126
Y+C+A+N G P+ + I L GR D + I +
Sbjct: 2743 YTCVASNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKD-------VIINNPI 2795
Query: 127 KISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTY 186
+ C+ A P LT W+K+G PL SS++++I PG L I K D G Y
Sbjct: 2796 SLYCETNAAPPPTLT--WYKDGHPLTSSDKVLIL-------PGGRVLQIPRAKVEDAGRY 2846
Query: 187 TCVASLKGGGISDISIDVNISSSTVPP-----NLTVPQEKSPLVTREGDTIELQCQVTGK 241
TCVA + G + DV + VPP N +P+E + LV + ++C +G
Sbjct: 2847 TCVA-VNEAGEDSLQYDVRV---LVPPIIKGANSDLPEEVTVLVNKSA---LIECLSSGS 2899
Query: 242 PKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREA 301
P P W + D + + D + S L+I+N G Y C G K
Sbjct: 2900 PAPRNSWQK-DGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGSAKK---- 2954
Query: 302 LVQLIVQYPPAV-EPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFD 360
L V PP+V P + + ++++C V +P L++ L T
Sbjct: 2955 YFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEV-SGFPPPDLSWLKNEQPIKLNTNTLI 3013
Query: 361 SQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVTGKAYAP 404
+ + G Y C IN+AG + F +T Y P
Sbjct: 3014 VPGGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLT--VYVP 3055
Score = 84.3 bits (207), Expect = 4e-16
Identities = 92/375 (24%), Positives = 150/375 (40%), Gaps = 34/375 (9%)
Query: 25 VNPGEAITLVCVTTGGEPAPSLTWVRSFGTL---PEKTVLN-GGTLTIPAITSDDAGTYS 80
V G+ + + C G P P +TW + T+ E V N GTL+I T DAG Y+
Sbjct: 1182 VQVGQRVDIPC-NAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQATPSDAGIYT 1240
Query: 81 CIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGRE-VKISCQVEAVPSEE 139
C+A N G T I + + PY+ ++ + ++ C + P
Sbjct: 1241 CVATNIAGT---DETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKP- 1296
Query: 140 LTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISD 199
T W NGR L E + D T L I + D G Y CVA + G ++
Sbjct: 1297 -TIKWLHNGRELTGREPGISILED------GTLLVIASVTPYDNGEYICVA-VNEAGTTE 1348
Query: 200 ISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPD 259
++ + VPP + ++ + + L C+V G P PII+W + + +V
Sbjct: 1349 RKYNLKVH---VPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVT-ES 1404
Query: 260 GSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFL- 318
++Q + L++ + E +G Y C+ G + K + V PP +
Sbjct: 1405 STIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQK----YFNIDVLVPPTIIGTNFP 1460
Query: 319 -EIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAVKSLSN--- 374
E+ +R V + C+V + P + W K L G + + V L N
Sbjct: 1461 NEVSVVLNRDVALECQV-KGTPFPDI--HWFKDGKPLFLGDPNVELLDRGQVLHLKNARR 1517
Query: 375 ENYGVYNCSIINEAG 389
+ G Y C++ N AG
Sbjct: 1518 NDKGRYQCTVSNAAG 1532
Score = 83.2 bits (204), Expect = 8e-16
Identities = 96/384 (25%), Positives = 157/384 (40%), Gaps = 41/384 (10%)
Query: 13 PSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRS-FGTLPEKT---VLNGGTLTI 68
PSI D +V A+ + T G P PS+ W ++ LP +L+ G + I
Sbjct: 3897 PSIADEPTDFLVTKHAPAV--ITCTASGVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEI 3954
Query: 69 PAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKI 128
A + AG Y+C+A N G+ + T + I P P + ++ + + +
Sbjct: 3955 LATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPV-----IQPQP--SELHVILNNPILL 4007
Query: 129 SCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTC 188
C+ PS +T W K G + +S R + V P + L I D GTY C
Sbjct: 4008 PCEATGTPSPFIT--WQKEGINVNTSGR------NHAVLP-SGGLQISRAVREDAGTYMC 4058
Query: 189 VASLKGG-GISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIIL 247
VA G + I ++V VPP ++ P K ++ + I L C+ G P P I
Sbjct: 4059 VAQNPAGTALGKIKLNVQ-----VPPVIS-PHLKEYVIAVD-KPITLSCEADGLPPPDIT 4111
Query: 248 WSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIV 307
W + + A+ + Q G+L+I V +G Y C + G + +L V
Sbjct: 4112 WHKDGR--AIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSS----STSTKLTV 4165
Query: 308 QYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRT--GQFDSQEYT 365
PP + ++ + C V P + W+ N LL G++ ++ Y
Sbjct: 4166 HVPPRIRSTEGHYTVNENSQAILPC-VADGIPTPAI--NWKKDNVLLANLLGKYTAEPYG 4222
Query: 366 EYAVKSLSNENYGVYNCSIINEAG 389
E ++++ E+ G Y C N AG
Sbjct: 4223 ELILENVVLEDSGFYTCVANNAAG 4246
Score = 82.4 bits (202), Expect = 1e-15
Identities = 78/302 (25%), Positives = 123/302 (40%), Gaps = 30/302 (9%)
Query: 20 DDPIVVN--PGEAITLVCVTTGGEPAPSLTWVRSFGTL----PEKTVLNGGTLTIPAITS 73
D P+ ++ GE +TL C P P +TW + + P T L G++ I +
Sbjct: 1084 DKPVEISVLAGEEVTLPCEVKS-LPPPIITWAKETQLISPFSPRHTFLPSGSMKITETRT 1142
Query: 74 DDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVE 133
D+G Y C+A N GN ++ + V K I P H +Q+G+ V I C +
Sbjct: 1143 SDSGMYLCVATNIAGN-VTQAVKLNVHVPPK----IQRGPKHL--KVQVGQRVDIPCNAQ 1195
Query: 134 AVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLK 193
P +T W K G + ++ D GT ++D +D G YTCVA+
Sbjct: 1196 GTPLPVIT--WSKGGSTMLVDGEHHVSNPD-----GTLSID--QATPSDAGIYTCVAT-N 1245
Query: 194 GGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADK 253
G + I +++ +L P + IE C G PKP I W +
Sbjct: 1246 IAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGR 1305
Query: 254 EVAMPDGSMQMESYDGTLRIV-NVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPA 312
E+ + + + DGTL ++ +V+ +G Y C G E L V PP
Sbjct: 1306 ELTGREPGISILE-DGTLLVIASVTPYDNGEYICVAVNEAG----TTERKYNLKVHVPPV 1360
Query: 313 VE 314
++
Sbjct: 1361 IK 1362
Score = 80.9 bits (198), Expect = 4e-15
Identities = 96/381 (25%), Positives = 149/381 (39%), Gaps = 43/381 (11%)
Query: 23 IVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPE----KTVLNGGTLTIPAITSDDAGT 78
I+V G++I+L C G P P++TW++ L + + + G L + I D G
Sbjct: 2302 IIVTRGKSISLECEVQG-IPPPTVTWMKDGHPLIKAKGVEILDEGHILQLKNIHVSDTGR 2360
Query: 79 YSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGRE--VKISCQVEAVP 136
Y C+A N G KK ++ V A + +NI + + V ++C+ +P
Sbjct: 2361 YVCVAVNVAGMTDKKY-DLSVHAPPS-----IIGNHRSPENISVVEKNSVSLTCEASGIP 2414
Query: 137 SEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGG 196
+T WFK+G P+ S + I G L ++ D G YTCV G
Sbjct: 2415 LPSIT--WFKDGWPVSLSNSVRILS-------GGRMLRLMQTTMEDAGQYTCVVRNAAGE 2465
Query: 197 ISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVA 256
I S VPP++ + +E ++ L C+VTG P P I W + D +
Sbjct: 2466 ERKIFG----LSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHK-DGQPL 2520
Query: 257 MPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPA 316
D + + S L+I NV +G Y C S G K R + + V P
Sbjct: 2521 QEDEAHHIISGGRFLQITNVQVPHTGRYTCLASSPAGH--KSRSFSLNVF------VSPT 2572
Query: 317 FLEI-RQGQDRSVTM-----SCRVLRAYPIRVLTYEWRLGNKLLRTGQFDS--QEYTEYA 368
+ G VT+ + V AY T W L + +
Sbjct: 2573 IAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPGGRTLQ 2632
Query: 369 VKSLSNENYGVYNCSIINEAG 389
+ + +N G Y+C NEAG
Sbjct: 2633 ILNAQEDNAGRYSCVATNEAG 2653
Score = 79.7 bits (195), Expect = 9e-15
Identities = 79/327 (24%), Positives = 128/327 (39%), Gaps = 32/327 (9%)
Query: 25 VNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKT----VLNGGTLTIPAITSDDAGTYS 80
V G +++L C + P P +TW ++ + E T + +G L I D G Y
Sbjct: 3071 VREGTSVSLEC-ESNAVPPPVITWYKNGRMITESTHVEILADGQMLHIKKAEVSDTGQYV 3129
Query: 81 CIANNNVGNPAKK-STNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEE 139
C A N G K N+ V +G P + I V ++C +P
Sbjct: 3130 CRAINVAGRDDKNFHLNVYVPPSIEG-------PEREVIVETISNPVTLTCDATGIPPP- 3181
Query: 140 LTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISD 199
T +W KN + + +S+ + + + G + L I + +D G YTC+AS G
Sbjct: 3182 -TIAWLKNHKRIENSDSLEVR-----ILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQK 3235
Query: 200 ISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPD 259
S VPP++ + S + G+ +EL C G P P+I W + K +A +
Sbjct: 3236 YYF----LSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGE 3291
Query: 260 GSMQMESYDG-TLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFL 318
S +G TL I +G Y C + G + + L V P +
Sbjct: 3292 TERIRVSANGSTLNIYGALTSDTGKYTCVATNPAG----EEDRIFNLNVYVTPTIRGNKD 3347
Query: 319 EIRQGQ---DRSVTMSCRVLRAYPIRV 342
E + D S+ + CR P ++
Sbjct: 3348 EAEKLMTLVDTSINIECRATGTPPPQI 3374
Score = 79.0 bits (193), Expect = 1e-14
Identities = 90/376 (23%), Positives = 150/376 (39%), Gaps = 49/376 (13%)
Query: 30 AITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLN------GGTLTIPAITSDDAGTYSCIA 83
++TL C G P+P LTW++ +P K N G L I + D G Y C+A
Sbjct: 1658 SLTLEC-KAAGNPSPILTWLKD--GVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVA 1714
Query: 84 NNNVGNPA-KKSTNIIVRALKKG----RFWITPDPYHKDDNIQIGREVKISCQVEAVPSE 138
+ G K +++V +G ++I + + +++ C V P
Sbjct: 1715 TSVAGEKEIKYEVDVLVPPAIEGGDETSYFI----------VMVNNLLELDCHVTGSPPP 1764
Query: 139 ELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGIS 198
T W K+G+ + + I L I + ++ G Y C+A+ G
Sbjct: 1765 --TIMWLKDGQLIDERDGFKILLNG-------RKLVIAQAQVSNTGLYRCMAANTAGDHK 1815
Query: 199 DISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMP 258
+V + VPP + +V + + LQC G P P I W + D+ V
Sbjct: 1816 K-EFEVTVH---VPPTIKSSGLSERVVVKY-KPVALQCIANGIPNPSITWLKDDQPVNTA 1870
Query: 259 DGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFL 318
G+++++S L+I E +G Y C + G + +QL V PP++E A
Sbjct: 1871 QGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAG----ETQQHIQLHVHEPPSLEDAGK 1926
Query: 319 EIRQG--QDRSVTMSCRVLRAYPIRVLTYEWRLGNKLL--RTGQFDSQEYTEYAVKSLSN 374
+ + V + C+ P+ V+T W N+LL T ++S
Sbjct: 1927 MLNETVLVSNPVQLECKA-AGNPVPVIT--WYKDNRLLSGSTSMTFLNRGQIIDIESAQI 1983
Query: 375 ENYGVYNCSIINEAGA 390
+ G+Y C IN AGA
Sbjct: 1984 SDAGIYKCVAINSAGA 1999
Score = 78.6 bits (192), Expect = 2e-14
Identities = 87/381 (22%), Positives = 152/381 (39%), Gaps = 40/381 (10%)
Query: 30 AITLVCVTTGGEPAPSLTWVRSFGTLPEKT---VLNGGT-LTIPAITSDDAGTYSCIANN 85
+++L C +G P PS+TW + + +L+GG L + T +DAG Y+C+ N
Sbjct: 2403 SVSLTCEASG-IPLPSITWFKDGWPVSLSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRN 2461
Query: 86 NVGNPAKK-STNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSW 144
G K +++V G + +D ++ + V ++C+V P E+T W
Sbjct: 2462 AAGEERKIFGLSVLVPPHIVGENTL------EDVKVKEKQSVTLTCEVTGNPVPEIT--W 2513
Query: 145 FKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDV 204
K+G+PL+ E I G L I +++ G YTC+AS G S S +
Sbjct: 2514 HKDGQPLQEDEAHHIIS-------GGRFLQITNVQVPHTGRYTCLASSPAGHKSR-SFSL 2565
Query: 205 NISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQM 264
N+ S + + L C+ P I W + D + ++++
Sbjct: 2566 NVFVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITWFK-DGTPLESNRNIRI 2624
Query: 265 ESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFL------ 318
TL+I+N + +G Y C + G +K E V + PP + L
Sbjct: 2625 LPGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYI----PPIINKGDLWGPGLS 2680
Query: 319 --EIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYA--VKSLSN 374
E++ + ++T+ C AY I + W + L++ + + +K
Sbjct: 2681 PKEVKIKVNNTLTLEC---EAYAIPSASLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQI 2737
Query: 375 ENYGVYNCSIINEAGAGRCSF 395
+ G Y C N AG F
Sbjct: 2738 SDTGRYTCVASNIAGEDELDF 2758
Score = 78.6 bits (192), Expect = 2e-14
Identities = 105/406 (25%), Positives = 168/406 (41%), Gaps = 53/406 (13%)
Query: 10 TASPSIKLLVDDPIVVNP---------GEAITLVCVTTGGEPAPSLTWVRSFGTLPE--- 57
TA IKL V P V++P + ITL C G P P +TW + + E
Sbjct: 4066 TALGKIKLNVQVPPVISPHLKEYVIAVDKPITLSC-EADGLPPPDITWHKDGRAIVESIR 4124
Query: 58 KTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKD 117
+ VL+ G+L I + DAG Y+C+A N G+ + ST + V + R T Y +
Sbjct: 4125 QRVLSSGSLQIAFVQPGDAGHYTCMAANVAGS-SSTSTKLTVHVPPRIRS--TEGHYTVN 4181
Query: 118 DNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIID 177
+N Q + C + +P+ + +W K+ L + + + L + +
Sbjct: 4182 ENSQ----AILPCVADGIPTPAI--NWKKDNVLLANLLGKYTAEPYGE-------LILEN 4228
Query: 178 LKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQ 237
+ D G YTCVA+ G D + S TV T + + +G+ + L C+
Sbjct: 4229 VVLEDSGFYTCVANNAAGE------DTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCK 4282
Query: 238 VTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVK 297
TG P P + W+ + + S+ S L I VS+E SG Y C GF
Sbjct: 4283 ATGIPLPKLTWTFNNNIIPAHFDSVNGHS---ELVIERVSKEDSGTYVCTAENSVGFV-- 4337
Query: 298 PREALVQLIVQYPPAVEPAF----LEIRQGQDRSVTMSCRVLRAYPIRVLTYEW-RLGNK 352
+A+ + V+ PP + + +E G + ++C V + P T +W R G
Sbjct: 4338 --KAIGFVYVKEPPVFKGDYPSNWIEPLGG---NAILNCEV-KGDPTP--TIQWNRKGVD 4389
Query: 353 LLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVT 398
+ + + A+ NE+ G Y C NEAG S +T
Sbjct: 4390 IEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLT 4435
Score = 77.4 bits (189), Expect = 4e-14
Identities = 91/373 (24%), Positives = 144/373 (38%), Gaps = 36/373 (9%)
Query: 32 TLVCVTTGGEPAPSLTWVRSFGTLP------EKTVLNGGTLTIPAITSDDAGTYSCIANN 85
TL C TG P PS+ W ++ L +L+ G+L I + + DD TY C N
Sbjct: 3822 TLACEATG-IPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTN 3880
Query: 86 NVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWF 145
G+ K++ ++ V+ I +P D + I+C VP + W
Sbjct: 3881 GAGDD-KRTVDLTVQVPPS----IADEP--TDFLVTKHAPAVITCTASGVPFPSI--HWT 3931
Query: 146 KNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVN 205
KNG L + + D + ++I+ + G YTCVA G S +
Sbjct: 3932 KNGIRL-------LPRGDGYRILSSGAIEILATQLNHAGRYTCVARNAAG-----SAHRH 3979
Query: 206 ISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQME 265
++ P + PQ S L + I L C+ TG P P I W + V G
Sbjct: 3980 VTLHVHEPPVIQPQ-PSELHVILNNPILLPCEATGTPSPFITWQKEGINV-NTSGRNHAV 4037
Query: 266 SYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQD 325
G L+I RE +G Y C G + ++L VQ PP + P E D
Sbjct: 4038 LPSGGLQISRAVREDAGTYMCVAQNPAGTAL----GKIKLNVQVPPVISPHLKEYVIAVD 4093
Query: 326 RSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSII 385
+ +T+SC P + + + G ++ + + + + + G Y C
Sbjct: 4094 KPITLSCEADGLPPPDITWH--KDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAA 4151
Query: 386 NEAGAGRCSFLVT 398
N AG+ S +T
Sbjct: 4152 NVAGSSSTSTKLT 4164
Score = 77.0 bits (188), Expect = 6e-14
Identities = 67/284 (23%), Positives = 118/284 (41%), Gaps = 34/284 (11%)
Query: 16 KLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLN----GGTLTIPAI 71
K+L + +V NP + L C G P P +TW + L T + G + I +
Sbjct: 1926 KMLNETVLVSNP---VQLEC-KAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESA 1981
Query: 72 TSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQI--GREVKIS 129
DAG Y C+A N+ G +T + + + P ++ + + V++
Sbjct: 1982 QISDAGIYKCVAINSAG-----ATELFYSL----QVHVAPSISGSNNMVAVVVNNPVRLE 2032
Query: 130 CQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCV 189
C+ +P+ LT W K+G P+ S + V G L + + +D G YTCV
Sbjct: 2033 CEARGIPAPSLT--WLKDGSPVSSFSNGL------QVLSGGRILALTSAQISDTGRYTCV 2084
Query: 190 ASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWS 249
A + G ID+ + VPPN+ ++ ++ + +EL CQ P P + W
Sbjct: 2085 A-VNAAGEKQRDIDLRV---YVPPNIMGEEQNVSVLISQ--AVELLCQSDAIPPPTLTWL 2138
Query: 250 RADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNG 293
+ D + + + L+I + + +G Y C+ + G
Sbjct: 2139 K-DGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAG 2181
Score = 73.6 bits (179), Expect = 6e-13
Identities = 89/354 (25%), Positives = 149/354 (42%), Gaps = 43/354 (12%)
Query: 45 SLTWVRSFGTLPEKTVLNGGT---LTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRA 101
+L++VR+ TL L L I +T D G Y CIA ++ G ++ +
Sbjct: 460 TLSFVRNGVTLGVDQYLKESASVNLDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSE- 518
Query: 102 LKKGRFWITPDPYHKDDNIQI--GREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVI 159
P +N+ + G ++C + + + + +W +N R +R +E I
Sbjct: 519 --------PPPVIQVPNNVTVTPGERAVLTCLI--ISAVDYNLTWQRNDRDVRLAEPARI 568
Query: 160 TQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTV-P 218
+ +L++ +KF D G Y C+ S +GG S S+ + + PP +TV P
Sbjct: 569 R------TLANLSLELKSVKFNDAGEYHCMVSSEGGS-SAASVFLTVQE---PPKVTVMP 618
Query: 219 QEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQME-SYDGTLRIVNVS 277
+ +S G + + C TG PKP I W+ D + GS + + DGTL I N +
Sbjct: 619 KNQS---FTGGSEVSIMCSATGYPKPKIAWTVNDMFIV---GSHRYRMTSDGTLFIKNAA 672
Query: 278 REMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRA 337
+ +G+Y C S N + + ++ I V + L + G M C+
Sbjct: 673 PKDAGIYGCLAS--NSAGTDKQNSTLRYIEAPKLMVVQSELLVALGD--ITVMECKTSGI 728
Query: 338 YPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAVKSLSNENY--GVYNCSIINEAG 389
P +V +W G+ LR F + +K ++ G Y C INEAG
Sbjct: 729 PPPQV---KWFKGDLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAG 779
Score = 70.9 bits (172), Expect = 4e-12
Identities = 97/400 (24%), Positives = 159/400 (39%), Gaps = 45/400 (11%)
Query: 11 ASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRS-----FGTLPEKTVLNGGT 65
+ P + V + + V PGE L C+ +LTW R+ L +
Sbjct: 517 SEPPPVIQVPNNVTVTPGERAVLTCLIISAVDY-NLTWQRNDRDVRLAEPARIRTLANLS 575
Query: 66 LTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGRE 125
L + ++ +DAG Y C+ ++ G+ A ++ + + + + P K+ + G E
Sbjct: 576 LELKSVKFNDAGEYHCMVSSEGGSSA---ASVFLTVQEPPKVTVMP----KNQSFTGGSE 628
Query: 126 VKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGT 185
V I C P ++ +W N + S R +T S GT L I + D G
Sbjct: 629 VSIMCSATGYPKPKI--AWTVNDMFIVGSHRYRMT------SDGT--LFIKNAAPKDAGI 678
Query: 186 YTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPI 245
Y C+AS G S I + P L V Q S L+ GD ++C+ +G P P
Sbjct: 679 YGCLASNSAGTDKQNSTLRYIEA----PKLMVVQ--SELLVALGDITVMECKTSGIPPPQ 732
Query: 246 ILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQL 305
+ W + D E+ P + ++ G L+I +G Y C G + L
Sbjct: 733 VKWFKGDLEL-RPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAG----RATGKITL 787
Query: 306 IVQYPPAV--EPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQE 363
V PP EPA + + G +VT+ C V + YP + + RL N + + F
Sbjct: 788 DVGSPPVFIQEPADVSMEIGS--NVTLPCYV-QGYPEPTIKWR-RLDNMPIFSRPFSVSS 843
Query: 364 YTEYA-----VKSLSNENYGVYNCSIINEAGAGRCSFLVT 398
++ + +L + G Y C N+ G + VT
Sbjct: 844 ISQLRTGALFILNLWASDKGTYICEAENQFGKIQSETTVT 883
Score = 66.6 bits (161), Expect = 8e-11
Identities = 71/314 (22%), Positives = 125/314 (39%), Gaps = 30/314 (9%)
Query: 23 IVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEK----TVLNGGTLTIPAITSDDAGT 78
+V+ ++ L C+ G P P +TW + L ++L G L I + D G
Sbjct: 3722 LVILLNKSTVLECIAEG-VPTPRITWRKDGAVLAGNHARYSILENGFLHIQSAHVTDTGR 3780
Query: 79 YSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSE 138
Y C+A N G ++ ++ V I P P + + + + ++C+ +P
Sbjct: 3781 YLCMATNAAGTD-RRRIDLQVHVPPS----IAPGPTNM--TVIVNVQTTLACEATGIPKP 3833
Query: 139 ELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGIS 198
+ +W KNG L + + +S G +L II D TY C + G G
Sbjct: 3834 SI--NWRKNGHLLNVDQNQNSYRL---LSSG--SLVIISPSVDDTATYECTVT-NGAGDD 3885
Query: 199 DISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMP 258
++D+ + VPP++ + LVT+ + + C +G P P I W++ + +P
Sbjct: 3886 KRTVDLTVQ---VPPSI-ADEPTDFLVTKHAPAV-ITCTASGVPFPSIHWTKNGIRL-LP 3939
Query: 259 DGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFL 318
G G + I+ +G Y C G V L V PP ++P
Sbjct: 3940 RGDGYRILSSGAIEILATQLNHAGRYTCVARNAAG----SAHRHVTLHVHEPPVIQPQPS 3995
Query: 319 EIRQGQDRSVTMSC 332
E+ + + + C
Sbjct: 3996 ELHVILNNPILLPC 4009
Score = 55.8 bits (133), Expect = 1e-07
Identities = 63/270 (23%), Positives = 109/270 (40%), Gaps = 30/270 (11%)
Query: 127 KISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTY 186
+I C V+++ T S+ +NG L + + + NLDI + +D G Y
Sbjct: 448 QIPCSVDSLLP--FTLSFVRNGVTLGVDQYLK--------ESASVNLDIAKVTLSDEGFY 497
Query: 187 TCVA-SLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPI 245
C+A S G G + DV S PP + VP + G+ L C +
Sbjct: 498 ECIAVSSAGTGRAQTFFDV----SEPPPVIQVPNN---VTVTPGERAVLTCLIISAVDYN 550
Query: 246 ILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQL 305
+ W R D++V + + + + +L + +V +G Y C S G + A V L
Sbjct: 551 LTWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHCMVSSEGGSSA----ASVFL 606
Query: 306 IVQYPP--AVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNK-LLRTGQFDSQ 362
VQ PP V P G + S+ S YP + W + + ++ + ++
Sbjct: 607 TVQEPPKVTVMPKNQSFTGGSEVSIMCSA---TGYPKPKIA--WTVNDMFIVGSHRYRMT 661
Query: 363 EYTEYAVKSLSNENYGVYNCSIINEAGAGR 392
+K+ + ++ G+Y C N AG +
Sbjct: 662 SDGTLFIKNAAPKDAGIYGCLASNSAGTDK 691
Score = 43.5 bits (101), Expect = 7e-04
Identities = 30/92 (32%), Positives = 42/92 (45%), Gaps = 4/92 (4%)
Query: 1 MVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVR---SFGTLPE 57
+V +S SP I L V+N G I L C T GEP P++TW R S
Sbjct: 4427 VVERSMSLTLQSPPIITLEPVETVINAGGKIILNCQAT-GEPQPTITWSRQGHSISWDDR 4485
Query: 58 KTVLNGGTLTIPAITSDDAGTYSCIANNNVGN 89
VL+ +L I +D + C+A N +G+
Sbjct: 4486 VNVLSNNSLYIADAQKEDTSEFECVARNLMGS 4517
>gi|109150416 peroxidasin [Homo sapiens]
Length = 1479
Score = 98.6 bits (244), Expect = 2e-20
Identities = 97/388 (25%), Positives = 157/388 (40%), Gaps = 48/388 (12%)
Query: 25 VNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKT-----VLNGGTLTIPAITSDDAGTY 79
V G + C G P P + W+R+ L KT +L+ GTL I D G Y
Sbjct: 257 VTSGNTVYFTC-RAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETDQGIY 315
Query: 80 SCIANNNVGNPAKKSTNIIVRAL---KKGRFWITPDPYHKDDNIQIGREVKISCQVEAVP 136
C+A N G K+ + +R + F I P ++ + +G V + C P
Sbjct: 316 QCMAKNVAGEV--KTQEVTLRYFGSPARPTFVIQP----QNTEVLVGESVTLECSATGHP 369
Query: 137 SEELTFSWFKNGR-PLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGG 195
+ SW + R PL R+ IT + L I ++ D G Y C A+
Sbjct: 370 PPRI--SWTRGDRTPLPVDPRVNITPSG--------GLYIQNVVQGDSGEYACSAT---N 416
Query: 196 GISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEV 255
I + I +P PQ++ V EG T++ QC+ G P P+I W++ ++
Sbjct: 417 NIDSVHATAFIIVQALPQFTVTPQDR---VVIEGQTVDFQCEAKGNPPPVIAWTKGGSQL 473
Query: 256 AMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEP 315
++ + + S GTLRI V+ G Y CQ G ++ + L VQ P V P
Sbjct: 474 SVDRRHLVLSS--GTLRISGVALHDQGQYECQAVNIIG----SQKVVAHLTVQ--PRVTP 525
Query: 316 AFLEIRQGQDRSVTMSCRV-----LRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAVK 370
F I D +V + V + P +T+ + G ++ +G+F +
Sbjct: 526 VFASI--PSDTTVEVGANVQLPCSSQGEPEPAITWN-KDGVQVTESGKFHISPEGFLTIN 582
Query: 371 SLSNENYGVYNCSIINEAGAGRCSFLVT 398
+ + G Y C N G+ S +++
Sbjct: 583 DVGPADAGRYECVARNTIGSASVSMVLS 610
>gi|75709184 contactin 3 [Homo sapiens]
Length = 1028
Score = 97.4 bits (241), Expect = 4e-20
Identities = 114/509 (22%), Positives = 200/509 (39%), Gaps = 67/509 (13%)
Query: 13 PSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLN----GGTLTI 68
P I++ + + G + L C G P P + W RS G LP + + G L I
Sbjct: 227 PKIEVQFPETLPAAKGSTVKLECFALGN-PIPQINWRRSDG-LPFSSKIKLRKFSGVLEI 284
Query: 69 PAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYH----KDDNIQIGR 124
P +DAG+Y CIA N+ G + + +GR P+ KD I +
Sbjct: 285 PNFQQEDAGSYECIAENSRG-----------KNVARGRLTYYAKPHWVQLIKDVEIAVED 333
Query: 125 EVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFG 184
+ C+ P ++ W KNG L ER TQ + L I +L TD G
Sbjct: 334 SLYWECRASGKPKP--SYRWLKNGAALVLEER---TQIENGA------LTISNLSVTDSG 382
Query: 185 TYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKP 244
+ C+A K G + S ++ + +S P+ + K + + G + L C+ P+
Sbjct: 383 MFQCIAENKHGLVYS-SAELKVVASA--PDFSKNPMKKLVQVQVGSLVSLDCKPRASPRA 439
Query: 245 IILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQ 304
+ W + D V + + DG L+I NV++ +G Y C G
Sbjct: 440 LSSWKKGDVSVQEHERISLLN--DGGLKIANVTKADAGTYTCMAENQFG----KANGTTH 493
Query: 305 LIVQYPPAV--EPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQ 362
L+V P + P+ +++ G+ SV + C+V + P+ + + W N L + D
Sbjct: 494 LVVTEPTRITLAPSNMDVSVGE--SVILPCQV-QHDPLLDIIFTWYF-NGALADFKKDGS 549
Query: 363 EYT--------EYAVKSLSNENYGVYNCSIIN--EAGAGRCSFLVTGKAYAPEFYYDTYN 412
+ + ++++ ++ G Y C + ++ + +V G PE
Sbjct: 550 HFEKVGGSSSGDLMIRNIQLKHSGKYVCMVQTGVDSVSSAADLIVRGSPGPPE------- 602
Query: 413 PVWQNRHRVYSYSLQWTQMNPDAVDRIVAYRLGIRQAGQQRWWEQEIKINGNIQKGELIT 472
V + + L W + D +++Y + R W Q + + G+ T
Sbjct: 603 NVKVDEITDTTAQLSWKE-GKDNHSPVISYSIQARTPFSVGW--QTVTTVPEVIDGKTHT 659
Query: 473 YNLTELIKPEAYEVRLTPLTKFGEGDSTI 501
+ EL YE R+ K G G+ ++
Sbjct: 660 ATVVELNPWVEYEFRVVASNKIGGGEPSL 688
Score = 79.7 bits (195), Expect = 9e-15
Identities = 95/396 (23%), Positives = 155/396 (39%), Gaps = 51/396 (12%)
Query: 31 ITLVCVTTGGEPAPSLTWVRSFG----TLPEKTVLNGGTLTIPAITSD-DAGTYSCIANN 85
ITL C G P+P W + ++ + LNGG L + + D GTY C A N
Sbjct: 46 ITLHCEARGN-PSPHYRWQLNGSDIDMSMEHRYKLNGGNLVVINPNRNWDTGTYQCFATN 104
Query: 86 NVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWF 145
++G + + L+ + +++ G+ V + C S EL+++W
Sbjct: 105 SLGTIVSREAKLQFAYLENFK-----TKMRSTVSVREGQGVVLLCG-PPPHSGELSYAWI 158
Query: 146 KNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVN 205
N P V + VS T +L I ++ +D G YTCV ++ + +
Sbjct: 159 FNEYP-----SFVEEDSRRFVSQETGHLYISKVEPSDVGNYTCV-------VTSMVTNAR 206
Query: 206 ISSSTVP-------------PNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRAD 252
+ S P P + V Q L +G T++L+C G P P I W R+D
Sbjct: 207 VLGSPTPLVLRSDGVMGEYEPKIEV-QFPETLPAAKGSTVKLECFALGNPIPQINWRRSD 265
Query: 253 KEVAMPDGS-MQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPP 311
+P S +++ + G L I N +E +G Y C G NV A +L P
Sbjct: 266 ---GLPFSSKIKLRKFSGVLEIPNFQQEDAGSYECIAENSRGKNV----ARGRLTYYAKP 318
Query: 312 AVEPAFLEIRQGQDRSVTMSCRVL-RAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAVK 370
++ + S+ CR + P +Y W L + E +
Sbjct: 319 HWVQLIKDVEIAVEDSLYWECRASGKPKP----SYRWLKNGAALVLEERTQIENGALTIS 374
Query: 371 SLSNENYGVYNCSIINEAGAGRCSFLVTGKAYAPEF 406
+LS + G++ C N+ G S + A AP+F
Sbjct: 375 NLSVTDSGMFQCIAENKHGLVYSSAELKVVASAPDF 410
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 97.1 bits (240), Expect = 5e-20
Identities = 106/409 (25%), Positives = 170/409 (41%), Gaps = 38/409 (9%)
Query: 4 FRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTW------VRSFGTLPE 57
FR+ + PS + D I G +TL C G P + W +R L
Sbjct: 6166 FRIQERQLPPSFARQLKD-IEQTVGLPVTLTCRLNGSAPI-QVCWYRDGVLLRDDENLQT 6223
Query: 58 KTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKD 117
V N TL I +G YSC A+N +G A S + R KK F+ D
Sbjct: 6224 SFVDNVATLKILQTDLSHSGQYSCSASNPLGT-ASSSARLTAREPKKSPFF---DIKPVS 6279
Query: 118 DNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIID 177
++ G C V ++ + +W K+ + +R IT T +L I+
Sbjct: 6280 IDVIAGESADFECHVTG--AQPMRITWSKDNKEIRPGGNYTITCVG-----NTPHLRILK 6332
Query: 178 LKFTDFGTYTCVASLKGGGISDISIDVNISSSTV--PPNLTVPQEKSPLVTREGDTIELQ 235
+ D G YTC A+ +D+ D+ + +V PP E S V ++G++I+L+
Sbjct: 6333 VGKGDSGQYTCQAT------NDVGKDMCSAQLSVKEPPKFVKKLEASK-VAKQGESIQLE 6385
Query: 236 CQVTGKPKPIILWSRADKEVAMP-DGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGF 294
C+++G P+ + W R D E+ +M + L I S E SG Y C+ +NG
Sbjct: 6386 CKISGSPEIKVSWFRNDSELHESWKYNMSFINSVALLTINEASAEDSGDYICEA--HNG- 6442
Query: 295 NVKPREALVQLIVQYPPAV--EPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNK 352
V L V+ PP +P+ + +G D V + C + P V+ + R +
Sbjct: 6443 -VGDASCSTALTVKAPPVFTQKPSPVGALKGSD--VILQCEISGTPPFEVVWVKDRKQVR 6499
Query: 353 LLRTGQFDSQEY-TEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVTGK 400
+ + S+ + T + +L + G Y+C NE G+ CS V K
Sbjct: 6500 NSKKFKITSKHFDTSLHILNLEASDVGEYHCKATNEVGSDTCSCSVKFK 6548
Score = 92.0 bits (227), Expect = 2e-18
Identities = 102/382 (26%), Positives = 156/382 (40%), Gaps = 40/382 (10%)
Query: 28 GEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVL------NGGTLTIPAITSDDAGTYSC 81
GE TL C G P ++W + L N +L I + D G YSC
Sbjct: 7034 GEPATLQC-KVDGTPEIRISWYKEHTKLRSAPAYKMQFKNNVASLVINKVDHSDVGEYSC 7092
Query: 82 IANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELT 141
A+N+VG A S ++++A K F+ KD + +G V C++ SE L
Sbjct: 7093 KADNSVGAVA-SSAVLVIKARKLPPFFARK---LKDVHETLGFPVAFECRING--SEPLQ 7146
Query: 142 FSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDIS 201
SW+K+G L+ + L I+ + G Y C AS G S S
Sbjct: 7147 VSWYKDGVLLKDDANL-----QTSFVHNVATLQILQTDQSHIGQYNCSASNPLGTASS-S 7200
Query: 202 IDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGS 261
+ +S VPP + L E T +C VTG I W++ ++E+ P G+
Sbjct: 7201 AKLILSEHEVPPFFDLKPVSVDLALGESGT--FKCHVTGTAPIKITWAKDNREI-RPGGN 7257
Query: 262 MQMESYD--GTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPP----AVEP 315
+M + TL ++ V + +G Y C S G + QL VQ PP +EP
Sbjct: 7258 YKMTLVENTATLTVLKVGKGDAGQYTCYASNIAGKD----SCSAQLGVQEPPRFIKKLEP 7313
Query: 316 AFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAV---KSL 372
+ + QD C++ + I+VL Y+ ++ + +F AV +L
Sbjct: 7314 SRI---VKQDEFTRYECKIGGSPEIKVLWYKDE--TEIQESSKFRMSFVDSVAVLEMHNL 7368
Query: 373 SNENYGVYNCSIINEAGAGRCS 394
S E+ G Y C N AG+ S
Sbjct: 7369 SVEDSGDYTCEAHNAAGSASSS 7390
Score = 91.3 bits (225), Expect = 3e-18
Identities = 91/339 (26%), Positives = 145/339 (42%), Gaps = 31/339 (9%)
Query: 65 TLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGR 124
+L I + +DAG ++C A N+VG+ K S+ ++ +++ ++T P KD + G
Sbjct: 4169 SLEIIRVDMNDAGNFTCRATNSVGS--KDSSGALI--VQEPPSFVTK-PGSKD--VLPGS 4221
Query: 125 EVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFG 184
V + + S LT WFK + L S IT+ + S L++ +K +D G
Sbjct: 4222 AVCLKSTFQG--STPLTIRWFKGNKELVSGGSCYITKEALESS-----LELYLVKTSDSG 4274
Query: 185 TYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKP 244
TYTC S GG+ + S ++ + P E S L+ ++GD +L C+VTG P
Sbjct: 4275 TYTCKVSNVAGGV-ECSANLFVKE---PATFVEKLEPSQLL-KKGDATQLACKVTGTPPI 4329
Query: 245 IILWSRADKEV-AMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALV 303
I W D+E+ M LR+ +V E SG Y C+ G +
Sbjct: 4330 KITWFANDREIKESSKHRMSFVESTAVLRLTDVGIEDSGEYMCEAQNEAGSD----HCSS 4385
Query: 304 QLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQ----F 359
+IV+ P F I ++ V + V P + W N +LR+G+ F
Sbjct: 4386 IVIVKESPYFTKEFKPIEVLKEYDVMLLAEVAGTPPFEI---TWFKDNTILRSGRKYKTF 4442
Query: 360 DSQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVT 398
+ + G Y C + NE G+ CS VT
Sbjct: 4443 IQDHLVSLQILKFVAADAGEYQCRVTNEVGSSICSARVT 4481
Score = 90.1 bits (222), Expect = 6e-18
Identities = 96/410 (23%), Positives = 172/410 (41%), Gaps = 38/410 (9%)
Query: 21 DPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVL------NGGTLTIPAITSD 74
+P+ V+ G++ +L C G P ++W + L T N TL + +
Sbjct: 7968 EPVKVSVGDSASLQC-QLAGTPEIGVSWYKGDTKLRPTTTYKMHFRNNVATLVFNQVDIN 8026
Query: 75 DAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQ--IGREVKISCQV 132
D+G Y C A N+VG ST + V+ K + P + ++Q +G V C +
Sbjct: 8027 DSGEYICKAENSVGE-VSASTFLTVQEQK-----LPPSFSRQLRDVQETVGLPVVFDCAI 8080
Query: 133 EAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASL 192
SE ++ SW+K+G+PL+ S + + D T L+I + G Y+C A+
Sbjct: 8081 SG--SEPISVSWYKDGKPLKDSPNVQTSFLD-----NTATLNIFKTDRSLAGQYSCTATN 8133
Query: 193 KGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRAD 252
G S S + ++ PP + +P+ G++ + +C VTG + W++
Sbjct: 8134 PIGSASS-SARLILTEGKNPPFFDI--RLAPVDAVVGESADFECHVTGTQPIKVSWAKDS 8190
Query: 253 KEVAMPDGSMQMESYDGT--LRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQ-- 308
+E+ G Q+ + + L ++ V + SG Y C Y V QL ++
Sbjct: 8191 REIRS-GGKYQISYLENSAHLTVLKVDKGDSGQYTC----YAVNEVGKDSCTAQLNIKER 8245
Query: 309 -YPPAVEPAFLE-IRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYT- 365
PP+ E + + + S + RV + PI V Y+ + + + + T
Sbjct: 8246 LIPPSFTKRLSETVEETEGNSFKLEGRVAGSQPITVAWYKNNIEIQPTSNCEITFKNNTL 8305
Query: 366 EYAVKSLSNENYGVYNCSIINEAGAGRC-SFLVTGKAYAPEFYYDTYNPV 414
V+ + G+Y C + N+AG+ C S +V + P + PV
Sbjct: 8306 VLQVRKAGMNDAGLYTCKVSNDAGSALCTSSIVIKEPKKPPVFDQHLTPV 8355
Score = 89.7 bits (221), Expect = 8e-18
Identities = 98/406 (24%), Positives = 170/406 (41%), Gaps = 36/406 (8%)
Query: 21 DPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTL---PEKTVL---NGGTLTIPAITSD 74
+P+ G++++L C G P +++W + L PE N TL + +
Sbjct: 6086 EPLEAAVGDSVSLQC-QVAGTPEITVSWYKGDTKLRPTPEYRTYFTNNVATLVFNKVNIN 6144
Query: 75 DAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEA 134
D+G Y+C A N++G + K+ I F KD +G V ++C++
Sbjct: 6145 DSGEYTCKAENSIGTASSKTVFRIQERQLPPSF----ARQLKDIEQTVGLPVTLTCRLNG 6200
Query: 135 VPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKG 194
S + W+++G LR E + + D L I+ + G Y+C AS
Sbjct: 6201 --SAPIQVCWYRDGVLLRDDENLQTSFVD-----NVATLKILQTDLSHSGQYSCSASNPL 6253
Query: 195 GGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKE 254
G S S + P + ++ G++ + +C VTG I WS+ +KE
Sbjct: 6254 GTASS-SARLTAREPKKSPFFDIKPVSIDVIA--GESADFECHVTGAQPMRITWSKDNKE 6310
Query: 255 VAMPDGSMQMESYDGT--LRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPA 312
+ P G+ + T LRI+ V + SG Y CQ + G ++ QL V+ PP
Sbjct: 6311 IR-PGGNYTITCVGNTPHLRILKVGKGDSGQYTCQATNDVGKDM----CSAQLSVKEPPK 6365
Query: 313 -VEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAVKS 371
V+ Q S+ + C++ + I+V + R ++L + +++ A+ +
Sbjct: 6366 FVKKLEASKVAKQGESIQLECKISGSPEIKVSWF--RNDSELHESWKYNMSFINSVALLT 6423
Query: 372 L---SNENYGVYNCSIINEAGAGRCSFLVTGKAYAPEFYYDTYNPV 414
+ S E+ G Y C N G CS +T K AP + +PV
Sbjct: 6424 INEASAEDSGDYICEAHNGVGDASCSTALTVK--APPVFTQKPSPV 6467
Score = 89.4 bits (220), Expect = 1e-17
Identities = 93/377 (24%), Positives = 153/377 (40%), Gaps = 38/377 (10%)
Query: 28 GEAITLVCVTTGGEPAPSLTWVRSFGTLPEKT------VLNGGTLTIPAITSDDAGTYSC 81
G+A +C TG P W + L N L + +T D G YSC
Sbjct: 3565 GKAAKFICTVTG-TPVIETIWQKDGAALSPSPNWRISDAENKHILELSNLTIQDRGVYSC 3623
Query: 82 IANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELT 141
A+N G ++ II+ K F +P I ++V + CQV+ ++T
Sbjct: 3624 KASNKFGADICQAELIII---DKPHFIKELEPVQS----AINKKVHLECQVD--EDRKVT 3674
Query: 142 FSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDIS 201
+W K+G+ L + I D L+I K D GTY C AS + G S S
Sbjct: 3675 VTWSKDGQKLPPGKDYKICFEDK-----IATLEIPLAKLKDSGTYVCTASNEAGS-SSCS 3728
Query: 202 IDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDG- 260
V + PP+ + S L+ G++ L C++ G P + W + +KE++ +
Sbjct: 3729 ATVTVRE---PPSFVKKVDPSYLML-PGESARLHCKLKGSPVIQVTWFKNNKELSESNTV 3784
Query: 261 SMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEI 320
M + + L I +V E SG Y C+ G + E +++ + +EPA +I
Sbjct: 3785 RMYFVNSEAILDITDVKVEDSGSYSCEAVNDVGSDSCSTEIVIKEPPSFIKTLEPA--DI 3842
Query: 321 RQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQ----FDSQEYTEYAVKSLSNEN 376
+G + + C V P + W K +R+ + F + + S ++ +
Sbjct: 3843 VRG--TNALLQCEVSGTGPFEI---SWFKDKKQIRSSKKYRLFSQKSLVCLEIFSFNSAD 3897
Query: 377 YGVYNCSIINEAGAGRC 393
G Y C + NE G C
Sbjct: 3898 VGEYECVVANEVGKCGC 3914
Score = 89.0 bits (219), Expect = 1e-17
Identities = 99/398 (24%), Positives = 160/398 (40%), Gaps = 47/398 (11%)
Query: 13 PSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVL-----NG-GTL 66
P+ VDD I + G+ +TL G EP S+TW++ + E + NG L
Sbjct: 3924 PTFVKKVDDLIALG-GQTVTLQAAVRGSEPI-SVTWMKGQEVIREDGKIKMSFSNGVAVL 3981
Query: 67 TIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREV 126
IP + G Y+C+A N G+ I+ K + + IQ+
Sbjct: 3982 IIPDVQISFGGKYTCLAENEAGSQTSVGELIVKEPAKI---------IERAELIQVTAGD 4032
Query: 127 KISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTY 186
+ + + EL W+K+GRPL +S++ I+ L + D G Y
Sbjct: 4033 PATLEYTVAGTPELKPKWYKDGRPLVASKKYRIS-----FKNNVAQLKFYSAELHDSGQY 4087
Query: 187 TCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPII 246
T S + G S + + P T P V T L C++ G +
Sbjct: 4088 TFEISNEVGS-SSCETTFTVLDRDIAPFFTKPLRNVDSVV--NGTCRLDCKIAGSLPMRV 4144
Query: 247 LWSRADKEVAMPDGSMQMESYDGT--LRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQ 304
W + KE+A D ++ +GT L I+ V +G + C+ + +V +++
Sbjct: 4145 SWFKDGKEIAASD-RYRIAFVEGTASLEIIRVDMNDAGNFTCRATN----SVGSKDSSGA 4199
Query: 305 LIVQYPPA--VEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQ 362
LIVQ PP+ +P ++ G +V + + P LT W GNK L +G S
Sbjct: 4200 LIVQEPPSFVTKPGSKDVLPGS--AVCLKSTFQGSTP---LTIRWFKGNKELVSG--GSC 4252
Query: 363 EYTEYAVKS------LSNENYGVYNCSIINEAGAGRCS 394
T+ A++S + + G Y C + N AG CS
Sbjct: 4253 YITKEALESSLELYLVKTSDSGTYTCKVSNVAGGVECS 4290
Score = 88.6 bits (218), Expect = 2e-17
Identities = 94/395 (23%), Positives = 147/395 (37%), Gaps = 60/395 (15%)
Query: 28 GEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVL------NGGTLTIPAITSDDAGTYSC 81
G I L C+ G P S+ W + + N L I + D+GTY+C
Sbjct: 4689 GSFIDLECIVAGSHPI-SIQWFKDDQEISASEKYKFSFHDNTAFLEISQLEGTDSGTYTC 4747
Query: 82 IANNNVGNPAKKSTNIIVRALKKGRFWITPDPY--HKDDNIQIGREVKISCQVEAVPSEE 139
A N G+ G + PY K + + ++ + +
Sbjct: 4748 SATNKAGHNQCS-----------GHLTVKEPPYFVEKPQSQDVNPNTRVQLKALVGGTAP 4796
Query: 140 LTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISD 199
+T WFK+ + L S + + D +T+L++ K TD GTY C
Sbjct: 4797 MTIKWFKDNKELHSGAARSVWKDDT-----STSLELFAAKATDSGTYIC----------Q 4841
Query: 200 ISIDVNISSSTVPPNLTVPQE--KSP---LVTREGDTIELQCQVTGKPKPIILWSRADKE 254
+S DV ++S + P + K P LV R G + +CQ+TG PK + W E
Sbjct: 4842 LSNDVGTATSKATLFVKEPPQFIKKPSPVLVLRNGQSTTFECQITGTPKIRVSWYLDGNE 4901
Query: 255 V-AMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAV 313
+ A+ + T +I E SG Y C+ G ++L V+ PP
Sbjct: 4902 ITAIQKHGISFIDGLATFQISGARVENSGTYVCEARNDAG----TASCSIELKVKEPPTF 4957
Query: 314 EPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAVKSLS 373
+ + V + C V P V W N+ +R+ S++YT S+
Sbjct: 4958 IRELKPVEVVKYSDVELECEVTGTPPFEV---TWLKNNREIRS----SKKYTLTDRVSVF 5010
Query: 374 N--------ENYGVYNCSIINEAGAGRCSFLVTGK 400
N + G Y C + NE G+ CS V K
Sbjct: 5011 NLHITKCDPSDTGEYQCIVSNEGGSCSCSTRVALK 5045
Score = 87.8 bits (216), Expect = 3e-17
Identities = 99/410 (24%), Positives = 169/410 (41%), Gaps = 56/410 (13%)
Query: 21 DPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLN------GGTLTIPAITSD 74
+P+ V PG+ +T V G P + W R L + N L + I
Sbjct: 5900 EPLEVLPGKNVTFTSVIRGTPPF-KVNWFRGARELVKGDRCNIYFEDTVAELELFNIDIS 5958
Query: 75 DAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHK---DDNIQIGREVKI-SC 130
+G Y+C+ +NN G A +T + V+ P + K D +++ G+ + + S
Sbjct: 5959 QSGEYTCVVSNNAGQ-ASCTTRLFVKE---------PAAFLKRLSDHSVEPGKSIILEST 6008
Query: 131 QVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVA 190
+P ++ +W K+G + +SE+ I T+ T L+I++ D G Y+C
Sbjct: 6009 YTGTLP---ISVTWKKDGFNITTSEKCNIVTTEK-----TCILEILNSTKRDAGQYSCEI 6060
Query: 191 SLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSR 250
+ G + + S+ PP E PL GD++ LQCQV G P+ + W +
Sbjct: 6061 ENEAGR----DVCGALVSTLEPPYFVT--ELEPLEAAVGDSVSLQCQVAGTPEITVSWYK 6114
Query: 251 ADKEV-AMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNG-------FNVKPREAL 302
D ++ P+ + TL V+ SG Y C+ G F ++ R
Sbjct: 6115 GDTKLRPTPEYRTYFTNNVATLVFNKVNINDSGEYTCKAENSIGTASSKTVFRIQER--- 6171
Query: 303 VQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRL---GNKLLRTGQF 359
Q PP+ +I Q VT++CR+ + PI+V Y + ++ L+T
Sbjct: 6172 -----QLPPSFARQLKDIEQTVGLPVTLTCRLNGSAPIQVCWYRDGVLLRDDENLQTSFV 6226
Query: 360 DSQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVTGKAYAPEFYYD 409
D+ + LS+ G Y+CS N G S +T + ++D
Sbjct: 6227 DNVATLKILQTDLSHS--GQYSCSASNPLGTASSSARLTAREPKKSPFFD 6274
Score = 85.1 bits (209), Expect = 2e-16
Identities = 97/410 (23%), Positives = 170/410 (41%), Gaps = 55/410 (13%)
Query: 10 TASPSIKLLVDD----------PIVVNP--GEAITLVCVTTGGEPAPSLTW------VRS 51
TAS S KL++ + P+ V+ GE+ T C TG P +TW +R
Sbjct: 7196 TASSSAKLILSEHEVPPFFDLKPVSVDLALGESGTFKCHVTGTAPI-KITWAKDNREIRP 7254
Query: 52 FGTLPEKTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRF--WI 109
G V N TLT+ + DAG Y+C A+N G K S + + + RF +
Sbjct: 7255 GGNYKMTLVENTATLTVLKVGKGDAGQYTCYASNIAG---KDSCSAQLGVQEPPRFIKKL 7311
Query: 110 TPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPG 169
P K D + C++ P E+ W+K+ ++ S + ++ D
Sbjct: 7312 EPSRIVKQDEF-----TRYECKIGGSP--EIKVLWYKDETEIQESSKFRMSFVD-----S 7359
Query: 170 TTNLDIIDLKFTDFGTYTCVA-SLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTRE 228
L++ +L D G YTC A + G S S+ V PP ++ P+ T +
Sbjct: 7360 VAVLEMHNLSVEDSGDYTCEAHNAAGSASSSTSLKVK-----EPP--IFRKKPHPIETLK 7412
Query: 229 GDTIELQCQVTGKPKPIILWSRADKEV-AMPDGSMQMESYDGTLRIVNVSREMSGMYRCQ 287
G + L+C++ G P + W + +E+ + + E++ ++ I+NV G Y+C+
Sbjct: 7413 GADVHLECELQGTPPFHVSWYKDKRELRSGKKYKIMSENFLTSIHILNVDAADIGEYQCK 7472
Query: 288 TSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEW 347
+ +V + + ++ PP +I + V + + A PI V+ ++
Sbjct: 7473 ATN----DVGSDTCVGSIALKAPPRFVKKLSDISTVVGKEVQLQTTIEGAEPISVVWFKD 7528
Query: 348 RLGNKLLRTGQFDSQEYTE----YAVKSLSNENYGVYNCSIINEAGAGRC 393
+ +++R Y+E + N G Y C I N+AG C
Sbjct: 7529 K--GEIVRESDNIWISYSENIATLQFSRVEPANAGKYTCQIKNDAGMQEC 7576
Score = 84.0 bits (206), Expect = 5e-16
Identities = 85/354 (24%), Positives = 156/354 (44%), Gaps = 43/354 (12%)
Query: 66 LTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALK-----------KGRFWITPDPY 114
L I +D GTY+ +A+N VG + N+ + A + + P
Sbjct: 3401 LEIAEAYPEDEGTYTFVASNAVGQ-VSSTANLSLEAPESILHERIEQEIEMEMKAAPVIK 3459
Query: 115 HKDDNIQI--GREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTN 172
K + +++ G K +C++++ P+ + F WFK GR + S++ I S ++
Sbjct: 3460 RKIEPLEVALGHLAKFTCEIQSAPN--VRFQWFKAGREIYESDKCSIRS-----SKYISS 3512
Query: 173 LDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTI 232
L+I+ + D G YTC AS + G +S + + ++ + P L+ P+ L T G
Sbjct: 3513 LEILRTQVVDCGEYTCKASNEYGSVS-CTATLTVTEAYPPTFLSRPKS---LTTFVGKAA 3568
Query: 233 ELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDG--TLRIVNVSREMSGMYRCQTSQ 290
+ C VTG P +W + D P + ++ + L + N++ + G+Y C+ S
Sbjct: 3569 KFICTVTGTPVIETIWQK-DGAALSPSPNWRISDAENKHILELSNLTIQDRGVYSCKASN 3627
Query: 291 YNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLG 350
G ++ E ++ + +EP ++ ++ V + C+V R +T W
Sbjct: 3628 KFGADICQAELIIIDKPHFIKELEP----VQSAINKKVHLECQVDED---RKVTVTWSKD 3680
Query: 351 NKLLRTGQ-----FDSQEYT-EYAVKSLSNENYGVYNCSIINEAGAGRCSFLVT 398
+ L G+ F+ + T E + L + G Y C+ NEAG+ CS VT
Sbjct: 3681 GQKLPPGKDYKICFEDKIATLEIPLAKLKDS--GTYVCTASNEAGSSSCSATVT 3732
Score = 81.3 bits (199), Expect = 3e-15
Identities = 90/390 (23%), Positives = 152/390 (38%), Gaps = 38/390 (9%)
Query: 22 PIVVNPGEAITLVCVTTGGEPAPSLTW------VRSFGTLPEKTVLNGGTLTIPAITSDD 75
P+ GE+ C TG +P ++W +RS G + N LT+ + D
Sbjct: 8161 PVDAVVGESADFECHVTGTQPI-KVSWAKDSREIRSGGKYQISYLENSAHLTVLKVDKGD 8219
Query: 76 AGTYSCIANNNVGNPA-KKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEA 134
+G Y+C A N VG + NI R + + + + G K+ +V
Sbjct: 8220 SGQYTCYAVNEVGKDSCTAQLNIKERLIPPSFTKRLSETVEETE----GNSFKLEGRVAG 8275
Query: 135 VPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKG 194
S+ +T +W+KN ++ + IT + T L + D G YTC S
Sbjct: 8276 --SQPITVAWYKNNIEIQPTSNCEITFKN-----NTLVLQVRKAGMNDAGLYTCKVSNDA 8328
Query: 195 GGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKE 254
G S + I PP Q +P+ EG+ ++L C V G I W +A +E
Sbjct: 8329 GSALCTS-SIVIKEPKKPP--VFDQHLTPVTVSEGEYVQLSCHVQGSEPIRIQWLKAGRE 8385
Query: 255 VAMPDG-SMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAV 313
+ D S S L + +V++ SG Y C+ S G + + ++ PA
Sbjct: 8386 IKPSDRCSFSFASGTAVLELRDVAKADSGDYVCKASNVAGSDTTKSKVTIKDKPAVAPAT 8445
Query: 314 EPAFLE-----------IRQGQDRSVTMSCRVLRAYPIRVLTY---EWRLGNKLLRTGQF 359
+ A ++ IR + + T +V PI + + +WR N+ R
Sbjct: 8446 KKAAVDGRLFFVSEPQSIRVVEKTTATFIAKV-GGDPIPNVKWTKGKWRQLNQGGRVFIH 8504
Query: 360 DSQEYTEYAVKSLSNENYGVYNCSIINEAG 389
+ + ++ + + G+Y C NE G
Sbjct: 8505 QKGDEAKLEIRDTTKTDSGLYRCVAFNEHG 8534
Score = 78.2 bits (191), Expect = 3e-14
Identities = 90/384 (23%), Positives = 151/384 (39%), Gaps = 46/384 (11%)
Query: 25 VNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPE---KTVLNGGTLT---IPAITSDDAGT 78
VNP + L + G P ++ W + L ++V T T + A + D+GT
Sbjct: 4779 VNPNTRVQLKALVGGTAPM-TIKWFKDNKELHSGAARSVWKDDTSTSLELFAAKATDSGT 4837
Query: 79 YSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSE 138
Y C +N+VG K+T + + +F P P N G+ CQ+ P
Sbjct: 4838 YICQLSNDVGTATSKATLFVK---EPPQFIKKPSPVLVLRN---GQSTTFECQITGTP-- 4889
Query: 139 ELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGIS 198
++ SW+ +G + + ++ I+ D G I + + GTY C A G +
Sbjct: 4890 KIRVSWYLDGNEITAIQKHGISFID-----GLATFQISGARVENSGTYVCEAR-NDAGTA 4943
Query: 199 DISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMP 258
SI++ + PP T +E P+ + +EL+C+VTG P + W + ++E+
Sbjct: 4944 SCSIELKVKE---PP--TFIRELKPVEVVKYSDVELECEVTGTPPFEVTWLKNNREIRSS 4998
Query: 259 DGSMQMESYDG-TLRIVNVSREMSGMYRCQTSQYNGF-NVKPREALVQLIVQYPPAVEPA 316
+ L I +G Y+C S G + R AL + PP+
Sbjct: 4999 KKYTLTDRVSVFNLHITKCDPSDTGEYQCIVSNEGGSCSCSTRVALKE-----PPSFIKK 5053
Query: 317 FLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYA-------V 369
S T V + PI + W +++L D Y + +
Sbjct: 5054 IENTTTVLKSSATFQSTVAGSPPISIT---WLKDDQILDE---DDNVYISFVDSVATLQI 5107
Query: 370 KSLSNENYGVYNCSIINEAGAGRC 393
+S+ N + G Y C NE+G RC
Sbjct: 5108 RSVDNGHSGRYTCQAKNESGVERC 5131
Score = 77.8 bits (190), Expect = 3e-14
Identities = 96/416 (23%), Positives = 154/416 (37%), Gaps = 44/416 (10%)
Query: 13 PSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEK-----TVLNG-GTL 66
P++ + P+ V GE TL C G P S+ W + L + N +L
Sbjct: 5703 PAVIVEKAGPMTVTVGETCTLEC-KVAGTPELSVEWYKDGKLLTSSQKHKFSFYNKISSL 5761
Query: 67 TIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYH---KDDNIQIG 123
I ++ DAGTY+ NNVG K S +V + P + K+ +G
Sbjct: 5762 RILSVERQDAGTYTFQVQNNVG---KSSCTAVVDVSDRA----VPPSFTRRLKNTGGVLG 5814
Query: 124 REVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDF 183
+ C+V S ++ +WF + S + T +D L + L +D
Sbjct: 5815 ASCILECKVAG--SSPISVAWFHEKTKIVSGAKYQTTFSD-----NVCTLQLNSLDSSDM 5867
Query: 184 GTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPK 243
G YTCVA+ G D + TV + +E PL G + + G P
Sbjct: 5868 GNYTCVAANVAGS------DECRAVLTVQEPPSFVKEPEPLEVLPGKNVTFTSVIRGTPP 5921
Query: 244 PIILWSRADKEVAMPDG-SMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREAL 302
+ W R +E+ D ++ E L + N+ SG Y C S N
Sbjct: 5922 FKVNWFRGARELVKGDRCNIYFEDTVAELELFNIDISQSGEYTCVVSN----NAGQASCT 5977
Query: 303 VQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQ 362
+L V+ P A + +S+ + PI V W+ + T + +
Sbjct: 5978 TRLFVKEPAAFLKRLSDHSVEPGKSIILESTYTGTLPISV---TWKKDGFNITTSEKCNI 6034
Query: 363 EYTE----YAVKSLSNENYGVYNCSIINEAGAGRCSFLVTGKAYAPEFYYDTYNPV 414
TE + + + + G Y+C I NEAG C LV+ P ++ P+
Sbjct: 6035 VTTEKTCILEILNSTKRDAGQYSCEIENEAGRDVCGALVS--TLEPPYFVTELEPL 6088
Score = 76.3 bits (186), Expect = 1e-13
Identities = 83/332 (25%), Positives = 148/332 (44%), Gaps = 30/332 (9%)
Query: 75 DAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEA 134
D+G Y+ +N VG+ + ++T + L + P D++ G ++ C++
Sbjct: 4083 DSGQYTFEISNEVGSSSCETTFTV---LDRDIAPFFTKPLRNVDSVVNGT-CRLDCKIAG 4138
Query: 135 VPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKG 194
S + SWFK+G+ + +S+R I + GT +L+II + D G +TC A+
Sbjct: 4139 --SLPMRVSWFKDGKEIAASDRYRIAFVE-----GTASLEIIRVDMNDAGNFTCRAT-NS 4190
Query: 195 GGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKE 254
G D S + + P +T P K L G + L+ G I W + +KE
Sbjct: 4191 VGSKDSSGALIVQEP--PSFVTKPGSKDVL---PGSAVCLKSTFQGSTPLTIRWFKGNKE 4245
Query: 255 VAMPDGSMQM--ESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPA 312
+ + GS + E+ + +L + V SG Y C+ S G V+ +
Sbjct: 4246 L-VSGGSCYITKEALESSLELYLVKTSDSGTYTCKVSNVAGGVECSANLFVKEPATFVEK 4304
Query: 313 VEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEY-AVKS 371
+EP+ L +++G + ++C+V PI++ W ++ ++ + E AV
Sbjct: 4305 LEPSQL-LKKGD--ATQLACKVTGTPPIKIT---WFANDREIKESSKHRMSFVESTAVLR 4358
Query: 372 LSN---ENYGVYNCSIINEAGAGRCSFLVTGK 400
L++ E+ G Y C NEAG+ CS +V K
Sbjct: 4359 LTDVGIEDSGEYMCEAQNEAGSDHCSSIVIVK 4390
Score = 76.3 bits (186), Expect = 1e-13
Identities = 100/416 (24%), Positives = 168/416 (40%), Gaps = 55/416 (13%)
Query: 10 TASPSIKLLVDDPIV----VNPGEAIT-----LVCVTTGGEPAPSLTWVRSFG------- 53
TAS SI+L V +P + P E + L C TG P +TW+++
Sbjct: 4942 TASCSIELKVKEPPTFIRELKPVEVVKYSDVELECEVTGTPPF-EVTWLKNNREIRSSKK 5000
Query: 54 -TLPEK-TVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITP 111
TL ++ +V N L I D G Y CI +N G ST + ALK+ P
Sbjct: 5001 YTLTDRVSVFN---LHITKCDPSDTGEYQCIVSNE-GGSCSCSTRV---ALKE-----PP 5048
Query: 112 DPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTT 171
K +N + + Q S ++ +W K+ + L + + I+ D
Sbjct: 5049 SFIKKIENTTTVLKSSATFQSTVAGSPPISITWLKDDQILDEDDNVYISFVD-----SVA 5103
Query: 172 NLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDT 231
L I + G YTC A + G ++ + V + ++ + E D
Sbjct: 5104 TLQIRSVDNGHSGRYTCQAKNESG------VERCYAFLLVQEPAQIVEKAKSVDVTEKDP 5157
Query: 232 IELQCQVTGKPKPIILWSRADKEVAMPDG--SMQMESYDGTLRIVNVSREMSGMYRCQTS 289
+ L+C V G P+ + W + K++ +P SM E+ + RI +V ++ SG Y +
Sbjct: 5158 MTLECVVAGTPELKVKWLKDGKQI-VPSRYFSMSFENNVASFRIQSVMKQDSGQYTFKVE 5216
Query: 290 QYNGFNVKPREALVQLIVQ-YPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWR 348
N F +A ++++ Q PP+ ++ + S+ M C+V + PI +W
Sbjct: 5217 --NDFGSSSCDAYLRVLDQNIPPSFTKKLTKMDKVLGSSIHMECKVSGSLPISA---QWF 5271
Query: 349 LGNKLLRTGQ----FDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVTGK 400
K + T + V +L E+ Y C + N AG CS ++T K
Sbjct: 5272 KDGKEISTSAKYRLVCHERSVSLEVNNLELEDTANYTCKVSNVAGDDACSGILTVK 5327
Score = 75.1 bits (183), Expect = 2e-13
Identities = 97/408 (23%), Positives = 167/408 (40%), Gaps = 45/408 (11%)
Query: 7 SNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTL---PEKTVLNG 63
S K P I PI G + L C G P ++W + L + +++
Sbjct: 7392 SLKVKEPPIFRKKPHPIETLKGADVHLECELQGTPPF-HVSWYKDKRELRSGKKYKIMSE 7450
Query: 64 GTLT---IPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHK---D 117
LT I + + D G Y C A N+VG+ T + ALK P + K D
Sbjct: 7451 NFLTSIHILNVDAADIGEYQCKATNDVGS----DTCVGSIALK------APPRFVKKLSD 7500
Query: 118 DNIQIGREVKISCQVEAVPSEELTFSWFKN-GRPLRSSERMVITQTDPDVSPGTTNLDII 176
+ +G+EV++ +E +E ++ WFK+ G +R S+ + I+ ++ L
Sbjct: 7501 ISTVVGKEVQLQTTIEG--AEPISVVWFKDKGEIVRESDNIWISYSE-----NIATLQFS 7553
Query: 177 DLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQC 236
++ + G YTC +D + ++ +V T+ ++ + GDT L+C
Sbjct: 7554 RVEPANAGKYTCQIK------NDAGMQECFATLSVLEPATIVEKPESIKVTTGDTCTLEC 7607
Query: 237 QVTGKPKPIILWSRADKEVAMPDGSMQMESYD--GTLRIVNVSREMSGMYRCQTSQYNGF 294
V G P+ W + KE+ D ++ ++ L+I+NV+ SG+Y + N
Sbjct: 7608 TVAGTPELSTKWFKDGKELT-SDNKYKISFFNKVSGLKIINVAPSDSGVYSFEVQ--NPV 7664
Query: 295 NVKPREALVQLIVQ-YPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKL 353
A +Q+ + PP+ E SV M C+V + PI V + GN++
Sbjct: 7665 GKDSCTASLQVSDRTVPPSFTRKLKETNGLSGSSVVMECKVYGSPPISVSWF--HEGNEI 7722
Query: 354 LRTGQFD---SQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVT 398
++ + V L + G Y C N AG+ CS +T
Sbjct: 7723 SSGRKYQTTLTDNTCALTVNMLEESDSGDYTCIATNMAGSDECSAPLT 7770
Score = 73.2 bits (178), Expect = 8e-13
Identities = 88/407 (21%), Positives = 163/407 (40%), Gaps = 54/407 (13%)
Query: 22 PIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPE----KTVLNGGTLTIPAITS--DD 75
P+ V G+ C G P P ++W + L K + +G T+ I + +D
Sbjct: 3247 PVTVQSGKPARF-CAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTLLLIEAFPED 3305
Query: 76 AGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPD---PYH--------KDDNIQIGR 124
A Y+C A N+ G A S ++ V + ++PD P + +D G+
Sbjct: 3306 AAVYTCEAKNDYG-VATTSASLSVEVPEV----VSPDQEMPVYPPAIITPLQDTVTSEGQ 3360
Query: 125 EVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFG 184
+ C+V +L SW+ + ++ S +TQ + T L+I + D G
Sbjct: 3361 PARFQCRVSGT---DLKVSWYSKDKKIKPSRFFRMTQFE-----DTYQLEIAEAYPEDEG 3412
Query: 185 TYTCVASLKGGGIS---DISIDV--NISSSTVPPNLTVPQEKSPLVTREGDTIEL----- 234
TYT VAS G +S ++S++ +I + + + + +P++ R+ + +E+
Sbjct: 3413 TYTFVASNAVGQVSSTANLSLEAPESILHERIEQEIEMEMKAAPVIKRKIEPLEVALGHL 3472
Query: 235 ---QCQVTGKPKPIILWSRADKEVAMPDG-SMQMESYDGTLRIVNVSREMSGMYRCQTSQ 290
C++ P W +A +E+ D S++ Y +L I+ G Y C+ S
Sbjct: 3473 AKFTCEIQSAPNVRFQWFKAGREIYESDKCSIRSSKYISSLEILRTQVVDCGEYTCKAS- 3531
Query: 291 YNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLG 350
N + A + + YPP + ++ C V I + W+
Sbjct: 3532 -NEYGSVSCTATLTVTEAYPPTFLSRPKSLTTFVGKAAKFICTVTGTPVIETI---WQKD 3587
Query: 351 NKLLRTGQ----FDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGRC 393
L D++ + +L+ ++ GVY+C N+ GA C
Sbjct: 3588 GAALSPSPNWRISDAENKHILELSNLTIQDRGVYSCKASNKFGADIC 3634
Score = 72.8 bits (177), Expect = 1e-12
Identities = 91/392 (23%), Positives = 144/392 (36%), Gaps = 42/392 (10%)
Query: 21 DPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEK-----TVLNG-GTLTIPAITSD 74
+P+ V G L CV TG P S W + L T +N +L IP
Sbjct: 6652 EPMTVTTGNPFALECVVTG-TPELSAKWFKDGRELSADSKHHITFINKVASLKIPCAEMS 6710
Query: 75 DAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYH---KDDNIQIGREVKISCQ 131
D G YS N+VG K + + V + I P + KD N +G V + C+
Sbjct: 6711 DKGLYSFEVKNSVG---KSNCTVSVHVSDR----IVPPSFIRKLKDVNAILGASVVLECR 6763
Query: 132 VEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVAS 191
V S ++ WF++G + S + S L++ L+ +D G YTCVA+
Sbjct: 6764 VSG--SAPISVGWFQDGNEIVSGPKC-----QSSFSENVCTLNLSLLEPSDTGIYTCVAA 6816
Query: 192 LKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRA 251
G D + TV + Q + G ++ + G P + W +
Sbjct: 6817 NVAGS------DECSAVLTVQEPPSFEQTPDSVEVLPGMSLTFTSVIRGTPPFKVKWFKG 6870
Query: 252 DKEVAMPDG-SMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYP 310
+E+ + ++ +E + L + V SG Y C + G L V+ P
Sbjct: 6871 SRELVPGESCNISLEDFVTELELFEVQPLESGDYSCLVTNDAG----SASCTTHLFVKEP 6926
Query: 311 PAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYA-- 368
+ + + PI V W L+ + S TE +
Sbjct: 6927 ATFVKRLADFSVETGSPIVLEATYTGTPPISV---SWIKDEYLISQSERCSITMTEKSTI 6983
Query: 369 --VKSLSNENYGVYNCSIINEAGAGRCSFLVT 398
+ + E+Y Y+C I NEAG C LV+
Sbjct: 6984 LEILESTIEDYAQYSCLIENEAGQDICEALVS 7015
Score = 70.1 bits (170), Expect = 7e-12
Identities = 90/368 (24%), Positives = 148/368 (40%), Gaps = 43/368 (11%)
Query: 37 TTGGEPAPSLTWVRSFGTLPEKTVL------NGGTLTIPAITSDDAGTYSCIANNNVGNP 90
T G ++TW++ + E + N +L + I G Y C A N+ G
Sbjct: 4508 TLKGSLPITVTWLKDSDEITEDDNIRMTFENNVASLYLSGIEVKHDGKYVCQAKNDAGIQ 4567
Query: 91 AKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRP 150
+ + K IT + +I + + + QV+ ++E+T WFK+G+
Sbjct: 4568 RCSALLSV-----KEPATITEEAV----SIDVTQGDPATLQVKFSGTKEITAKWFKDGQE 4618
Query: 151 LRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSST 210
L + I+ TD + L II + D G YT G S +N+
Sbjct: 4619 LTLGSKYKISVTDT-----VSILKIISTEKKDSGEYTFEVQ-NDVGRSSCKARINVLDLI 4672
Query: 211 VPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGT 270
+PP+ T +K + +G I+L+C V G I W + D+E++ + + +D T
Sbjct: 4673 IPPSFTKKLKKMDSI--KGSFIDLECIVAGSHPISIQWFKDDQEISASE-KYKFSFHDNT 4729
Query: 271 --LRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSV 328
L I + SG Y C + G N + L V+ P P F+E Q QD V
Sbjct: 4730 AFLEISQLEGTDSGTYTCSATNKAGHN----QCSGHLTVKEP----PYFVEKPQSQD--V 4779
Query: 329 TMSCRV-LRAY--PIRVLTYEWRLGNKLLRTGQ----FDSQEYTEYAVKSLSNENYGVYN 381
+ RV L+A +T +W NK L +G + T + + + G Y
Sbjct: 4780 NPNTRVQLKALVGGTAPMTIKWFKDNKELHSGAARSVWKDDTSTSLELFAAKATDSGTYI 4839
Query: 382 CSIINEAG 389
C + N+ G
Sbjct: 4840 CQLSNDVG 4847
Score = 69.3 bits (168), Expect = 1e-11
Identities = 84/348 (24%), Positives = 135/348 (38%), Gaps = 39/348 (11%)
Query: 75 DAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEA 134
D G Y+C A+N G+ + +T + A F P K +G+ K C V
Sbjct: 3522 DCGEYTCKASNEYGSVSCTATLTVTEAYPP-TFLSRP----KSLTTFVGKAAKFICTVTG 3576
Query: 135 VPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKG 194
P E W K+G L S I+ + L++ +L D G Y+C AS K
Sbjct: 3577 TPVIETI--WQKDGAALSPSPNWRISDAE-----NKHILELSNLTIQDRGVYSCKASNKF 3629
Query: 195 GGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKE 254
G D+ + + +E P+ + + L+CQV K + WS+ ++
Sbjct: 3630 GA------DICQAELIIIDKPHFIKELEPVQSAINKKVHLECQVDEDRKVTVTWSKDGQK 3683
Query: 255 VAM-PDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAV 313
+ D + E TL I + SG Y C S G + V+ + V
Sbjct: 3684 LPPGKDYKICFEDKIATLEIPLAKLKDSGTYVCTASNEAGSSSCSATVTVREPPSFVKKV 3743
Query: 314 EPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAVKS-- 371
+P++L + S + C+ L+ P+ +T W NK L +S Y V S
Sbjct: 3744 DPSYLML---PGESARLHCK-LKGSPVIQVT--WFKNNKELS----ESNTVRMYFVNSEA 3793
Query: 372 ------LSNENYGVYNCSIINEAGAGRCSFLVTGKAYAPEFYYDTYNP 413
+ E+ G Y+C +N+ G+ CS + K P + T P
Sbjct: 3794 ILDITDVKVEDSGSYSCEAVNDVGSDSCSTEIVIK--EPPSFIKTLEP 3839
Score = 68.6 bits (166), Expect = 2e-11
Identities = 74/344 (21%), Positives = 143/344 (41%), Gaps = 51/344 (14%)
Query: 65 TLTIPAITSDDAGTYSCIANNNVGNPA-------KKSTNIIVRALKKGRFWITPDPYHKD 117
+L + + +D Y+C +N G+ A K+ + +V K GR PD
Sbjct: 5293 SLEVNNLELEDTANYTCKVSNVAGDDACSGILTVKEPPSFLV---KPGRQQAIPDS---- 5345
Query: 118 DNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIID 177
V+ ++ P ++ WFK+ L S + I + T+ L++
Sbjct: 5346 -------TVEFKAILKGTPPFKI--KWFKDDVELVSGPKCFI-----GLEGSTSFLNLYS 5391
Query: 178 LKFTDFGTYTCVASLKGGGISDISID--VNISSSTVPPNLTVPQEKSPLVTREGDTIELQ 235
+ + G YTC + +D+ D + T PP E S +V + GD+ L+
Sbjct: 5392 VDASKTGQYTCHVT------NDVGSDSCTTMLLVTEPPKFVKKLEASKIV-KAGDSSRLE 5444
Query: 236 CQVTGKPKPIILWSRADKEVAMPDGSMQMESYD--GTLRIVNVSREMSGMYRCQTSQYNG 293
C++ G P+ ++W R + E+ D +M D +++ N+S E SG + C+ G
Sbjct: 5445 CKIAGSPEIRVVWFRNEHELPASD-KYRMTFIDSVAVIQMNNLSTEDSGDFICEAQNPAG 5503
Query: 294 FNVKPREALVQ---LIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLG 350
+ +V+ + +PP VE ++ V++ C + P V+ Y+ +
Sbjct: 5504 STSCSTKVIVKEPPVFSSFPPIVETL-------KNAEVSLECELSGTPPFEVVWYKDKRQ 5556
Query: 351 NKLLRTGQFDSQEY-TEYAVKSLSNENYGVYNCSIINEAGAGRC 393
+ + + S+ + T + ++ + G Y+C NE G+ C
Sbjct: 5557 LRSSKKYKIASKNFHTSIHILNVDTSDIGEYHCKAQNEVGSDTC 5600
Score = 68.2 bits (165), Expect = 3e-11
Identities = 84/334 (25%), Positives = 137/334 (41%), Gaps = 37/334 (11%)
Query: 65 TLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGR 124
TL IP D+GTY C A+N G+ + +T V + F DP + + G
Sbjct: 3700 TLEIPLAKLKDSGTYVCTASNEAGSSSCSAT---VTVREPPSFVKKVDPSYL---MLPGE 3753
Query: 125 EVKISCQVEAVPSEELTFSWFKNGRPLRSSE--RMVITQTDPDVSPGTTNLDIIDLKFTD 182
++ C+++ P ++T WFKN + L S RM ++ LDI D+K D
Sbjct: 3754 SARLHCKLKGSPVIQVT--WFKNNKELSESNTVRMYFVNSE-------AILDITDVKVED 3804
Query: 183 FGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKP 242
G+Y+C A + G S ++ I PP+ E + +V G LQC+V+G
Sbjct: 3805 SGSYSCEA-VNDVGSDSCSTEIVIKE---PPSFIKTLEPADIV--RGTNALLQCEVSGTG 3858
Query: 243 KPIILWSRADKEVAMPDGSMQMESYDG--TLRIVNVSREMSGMYRCQTSQYNGFNVKPRE 300
I W + DK+ ++ S L I + + G Y C + V
Sbjct: 3859 PFEISWFK-DKKQIRSSKKYRLFSQKSLVCLEIFSFNSADVGEYECVVAN----EVGKCG 3913
Query: 301 ALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLR-TGQF 359
+ +++ PP ++ ++VT+ V + PI V W G +++R G+
Sbjct: 3914 CMATHLLKEPPTFVKKVDDLIALGGQTVTLQAAVRGSEPISV---TWMKGQEVIREDGKI 3970
Query: 360 DSQEYTEYAVKSLSNENY---GVYNCSIINEAGA 390
AV + + G Y C NEAG+
Sbjct: 3971 KMSFSNGVAVLIIPDVQISFGGKYTCLAENEAGS 4004
Score = 66.6 bits (161), Expect = 8e-11
Identities = 91/405 (22%), Positives = 161/405 (39%), Gaps = 46/405 (11%)
Query: 17 LLVDDP---------IVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVL------ 61
LLV +P + V + +TL CV G P + W++ +
Sbjct: 5135 LLVQEPAQIVEKAKSVDVTEKDPMTLECVVAG-TPELKVKWLKDGKQIVPSRYFSMSFEN 5193
Query: 62 NGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQ 121
N + I ++ D+G Y+ N+ G+ S + +R L + K D +
Sbjct: 5194 NVASFRIQSVMKQDSGQYTFKVENDFGS---SSCDAYLRVLDQNIPPSFTKKLTKMDKV- 5249
Query: 122 IGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFT 181
+G + + C+V S ++ WFK+G+ + +S + + + VS L++ +L+
Sbjct: 5250 LGSSIHMECKVSG--SLPISAQWFKDGKEISTSAKYRLVCHERSVS-----LEVNNLELE 5302
Query: 182 DFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGK 241
D YTC S G I + PP+ V + + T+E + + G
Sbjct: 5303 DTANYTCKVSNVAGD----DACSGILTVKEPPSFLVKPGRQQAIP--DSTVEFKAILKGT 5356
Query: 242 PKPIILWSRADKE-VAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPRE 300
P I W + D E V+ P + +E L + +V +G Y C + +V
Sbjct: 5357 PPFKIKWFKDDVELVSGPKCFIGLEGSTSFLNLYSVDASKTGQYTCHVTN----DVGSDS 5412
Query: 301 ALVQLIVQYPPAVEPAF--LEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQ 358
L+V PP +I + D S + C++ + IRV+ + R ++L + +
Sbjct: 5413 CTTMLLVTEPPKFVKKLEASKIVKAGDSS-RLECKIAGSPEIRVVWF--RNEHELPASDK 5469
Query: 359 FDSQEYTEYAV---KSLSNENYGVYNCSIINEAGAGRCSFLVTGK 400
+ AV +LS E+ G + C N AG+ CS V K
Sbjct: 5470 YRMTFIDSVAVIQMNNLSTEDSGDFICEAQNPAGSTSCSTKVIVK 5514
Score = 66.6 bits (161), Expect = 8e-11
Identities = 91/409 (22%), Positives = 150/409 (36%), Gaps = 43/409 (10%)
Query: 21 DPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLNGGT------LTIPAITSD 74
DP+ V G +T + G P S++W + L N L + + +
Sbjct: 7782 DPMDVLTGTNVTFTSIVKGTPPF-SVSWFKGSSELVPGDRCNVSLEDSVAELELFDVDTS 7840
Query: 75 DAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHK---DDNIQIGREVKISCQ 131
+G Y+CI +N G A +T++ ++A P + K D +I+ G+ + +
Sbjct: 7841 QSGEYTCIVSNEAGK-ASCTTHLYIKA---------PAKFVKRLNDYSIEKGKPLILEGT 7890
Query: 132 VEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVAS 191
P +T W KNG + S+R IT T+ L+I D G Y C
Sbjct: 7891 FTGTPPISVT--WKKNGINVTPSQRCNITTTEKSAI-----LEIPSSTVEDAGQYNCYIE 7943
Query: 192 LKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRA 251
G S + I PP ++ P+ GD+ LQCQ+ G P+ + W +
Sbjct: 7944 -NASGKDSCSAQILILE---PPYFV--KQLEPVKVSVGDSASLQCQLAGTPEIGVSWYKG 7997
Query: 252 DKEV-AMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYP 310
D ++ M + TL V SG Y C+ G V L + P
Sbjct: 7998 DTKLRPTTTYKMHFRNNVATLVFNQVDINDSGEYICKAENSVG-EVSASTFLTVQEQKLP 8056
Query: 311 PAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYA-- 368
P+ ++++ V C + + PI V W K L+ + +
Sbjct: 8057 PSFSRQLRDVQETVGLPVVFDCAISGSEPISV---SWYKDGKPLKDSPNVQTSFLDNTAT 8113
Query: 369 --VKSLSNENYGVYNCSIINEAGAGRCSF-LVTGKAYAPEFYYDTYNPV 414
+ G Y+C+ N G+ S L+ + P F+ PV
Sbjct: 8114 LNIFKTDRSLAGQYSCTATNPIGSASSSARLILTEGKNPPFFDIRLAPV 8162
Score = 62.8 bits (151), Expect = 1e-09
Identities = 71/338 (21%), Positives = 133/338 (39%), Gaps = 38/338 (11%)
Query: 71 ITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISC 130
+ + D G Y C A N VG+ T V+ + RF + + G ++
Sbjct: 5579 VDTSDIGEYHCKAQNEVGSDTCVCT---VKLKEPPRFVSKLNSL----TVVAGEPAELQA 5631
Query: 131 QVEAVPSEELTFSWFKNGRP-LRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCV 189
+E ++ + W K +R SE + IT + L + + G Y C
Sbjct: 5632 SIEG--AQPIFVQWLKEKEEVIRESENIRITFVE-----NVATLQFAKAEPANAGKYICQ 5684
Query: 190 ASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWS 249
GG + N+++ V + ++ P+ G+T L+C+V G P+ + W
Sbjct: 5685 IKNDGG------MRENMATLMVLEPAVIVEKAGPMTVTVGETCTLECKVAGTPELSVEWY 5738
Query: 250 RADKEVAMPDGSMQMESYD--GTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIV 307
+ D ++ + Y+ +LRI++V R+ +G Y Q G + + ++
Sbjct: 5739 K-DGKLLTSSQKHKFSFYNKISSLRILSVERQDAGTYTFQVQNNVG-----KSSCTAVVD 5792
Query: 308 QYPPAVEPAFLEIRQGQ----DRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFD--- 360
AV P+F + S + C+V + PI V + + K++ ++
Sbjct: 5793 VSDRAVPPSFTRRLKNTGGVLGASCILECKVAGSSPISVAWFHEK--TKIVSGAKYQTTF 5850
Query: 361 SQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVT 398
S + SL + + G Y C N AG+ C ++T
Sbjct: 5851 SDNVCTLQLNSLDSSDMGNYTCVAANVAGSDECRAVLT 5888
Score = 57.8 bits (138), Expect = 4e-08
Identities = 87/403 (21%), Positives = 158/403 (39%), Gaps = 70/403 (17%)
Query: 25 VNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLNGGT-----------LTIPAITS 73
V PG A+ L G P ++ W + K +++GG+ L + + +
Sbjct: 4217 VLPGSAVCLKSTFQGSTPL-TIRWFKG-----NKELVSGGSCYITKEALESSLELYLVKT 4270
Query: 74 DDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVE 133
D+GTY+C +N G + S N+ V+ + F +P ++ G +++C+V
Sbjct: 4271 SDSGTYTCKVSNVAGG-VECSANLFVK--EPATFVEKLEP---SQLLKKGDATQLACKVT 4324
Query: 134 AVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLK 193
P ++T WF N R ++ S + ++ + T L + D+ D G Y C A +
Sbjct: 4325 GTPPIKIT--WFANDREIKESSKHRMSFVE-----STAVLRLTDVGIEDSGEYMCEAQNE 4377
Query: 194 GGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADK 253
G SI + S P T +E P+ + + L +V G P I W + D
Sbjct: 4378 AGSDHCSSIVIVKES----PYFT--KEFKPIEVLKEYDVMLLAEVAGTPPFEITWFK-DN 4430
Query: 254 EVAMPDGSMQ--MESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPP 311
+ + ++ + +L+I+ +G Y+C+ + G ++ ++ ++ PP
Sbjct: 4431 TILRSGRKYKTFIQDHLVSLQILKFVAADAGEYQCRVTNEVGSSI----CSARVTLREPP 4486
Query: 312 AVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAVKS 371
+ + + + + PI V T DS E TE
Sbjct: 4487 SFIKKIESTSSLRGGTAAFQATLKGSLPITV-------------TWLKDSDEITEDDNIR 4533
Query: 372 LSNENY--------------GVYNCSIINEAGAGRCSFLVTGK 400
++ EN G Y C N+AG RCS L++ K
Sbjct: 4534 MTFENNVASLYLSGIEVKHDGKYVCQAKNDAGIQRCSALLSVK 4576
Score = 57.8 bits (138), Expect = 4e-08
Identities = 83/379 (21%), Positives = 141/379 (37%), Gaps = 54/379 (14%)
Query: 28 GEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLNGG------------TLTIPAITSDD 75
G + L C G P S+ W EKT + G TL + ++ S D
Sbjct: 5814 GASCILECKVAGSSPI-SVAWFH------EKTKIVSGAKYQTTFSDNVCTLQLNSLDSSD 5866
Query: 76 AGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAV 135
G Y+C+A N G+ ++ ++ + F P+P + G+ V + +
Sbjct: 5867 MGNYTCVAANVAGSDECRA---VLTVQEPPSFVKEPEPL----EVLPGKNVTFTSVIRGT 5919
Query: 136 PSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGG 195
P ++ +WF+ R L +R I D L++ ++ + G YTCV S G
Sbjct: 5920 PPFKV--NWFRGARELVKGDRCNIYFEDT-----VAELELFNIDISQSGEYTCVVSNNAG 5972
Query: 196 GISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEV 255
S + V + S G +I L+ TG + W + +
Sbjct: 5973 QAS------CTTRLFVKEPAAFLKRLSDHSVEPGKSIILESTYTGTLPISVTWKKDGFNI 6026
Query: 256 AMPDG-SMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVE 314
+ ++ L I+N ++ +G Y C+ G +V ALV + PP
Sbjct: 6027 TTSEKCNIVTTEKTCILEILNSTKRDAGQYSCEIENEAGRDV--CGALVSTL--EPPYFV 6082
Query: 315 PAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAVKSLSN 374
+ SV++ C+V I T W G+ LR + EY Y +++
Sbjct: 6083 TELEPLEAAVGDSVSLQCQVAGTPEI---TVSWYKGDTKLR----PTPEYRTYFTNNVAT 6135
Query: 375 ENYGVYNCSIINEAGAGRC 393
V+N IN++G C
Sbjct: 6136 L---VFNKVNINDSGEYTC 6151
Score = 57.0 bits (136), Expect = 6e-08
Identities = 89/407 (21%), Positives = 155/407 (38%), Gaps = 53/407 (13%)
Query: 12 SPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLNGGTLTIPA- 70
+P + P+ G + L C +G P + WV+ K V N I +
Sbjct: 6456 APPVFTQKPSPVGALKGSDVILQCEISGTPPF-EVVWVKD-----RKQVRNSKKFKITSK 6509
Query: 71 ----------ITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNI 120
+ + D G Y C A N VG+ + + V+ + RF D +
Sbjct: 6510 HFDTSLHILNLEASDVGEYHCKATNEVGSD---TCSCSVKFKEPPRFV----KKLSDTST 6562
Query: 121 QIGREVKISCQVEAVPSEELTFSWFKN-GRPLRSSERMVITQTDPDVSPGTTNLDIIDLK 179
IG V++ VE + ++ W K+ G +R SE I+ D L + +
Sbjct: 6563 LIGDAVELRAIVEGF--QPISVVWLKDRGEVIRESENTRISFID-----NIATLQLGSPE 6615
Query: 180 FTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVT 239
++ G Y C G+ + S + TV + ++ P+ G+ L+C VT
Sbjct: 6616 ASNSGKYICQIK-NDAGMRECSAVL-----TVLEPARIIEKPEPMTVTTGNPFALECVVT 6669
Query: 240 GKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMS--GMYRCQTSQYNGFNVK 297
G P+ W + +E++ D + + + EMS G+Y + +V
Sbjct: 6670 GTPELSAKWFKDGRELS-ADSKHHITFINKVASLKIPCAEMSDKGLYSFEVKN----SVG 6724
Query: 298 PREALVQLIVQ---YPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLL 354
V + V PP+ ++ SV + CRV + PI V ++ GN+++
Sbjct: 6725 KSNCTVSVHVSDRIVPPSFIRKLKDVNAILGASVVLECRVSGSAPISVGWFQ--DGNEIV 6782
Query: 355 RTGQFDSQEYTEYAVKSLS---NENYGVYNCSIINEAGAGRCSFLVT 398
+ S +LS + G+Y C N AG+ CS ++T
Sbjct: 6783 SGPKCQSSFSENVCTLNLSLLEPSDTGIYTCVAANVAGSDECSAVLT 6829
Score = 55.8 bits (133), Expect = 1e-07
Identities = 48/199 (24%), Positives = 89/199 (44%), Gaps = 19/199 (9%)
Query: 200 ISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKE-VAMP 258
+SI ++S P + +E + T+ G+ +L CQ+ G+P P I W R KE +
Sbjct: 30521 MSIKTKLTSGEAPG---IRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSR 30577
Query: 259 DGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFL 318
M + TL ++ +E G+Y C + V E +L++Q P P +
Sbjct: 30578 KYKMSSDGRTHTLTVMTEEQEDEGVYTCIATN----EVGEVETSSKLLLQATPQFHPGY- 30632
Query: 319 EIRQGQDRSVTMSCRVLRAY---PIRVLTYEWRLGNKLLRTGQ----FDSQEYTEYAVKS 371
+++ +V + R+ Y P+ +T W G KLL+ + +++ YT +K+
Sbjct: 30633 PLKEKYYGAVGSTLRLHVMYIGRPVPAMT--WFHGQKLLQNSENITIENTEHYTHLVMKN 30690
Query: 372 LSNENY-GVYNCSIINEAG 389
+ + + G Y + N G
Sbjct: 30691 VQRKTHAGKYKVQLSNVFG 30709
Score = 55.8 bits (133), Expect = 1e-07
Identities = 83/391 (21%), Positives = 136/391 (34%), Gaps = 108/391 (27%)
Query: 6 LSNKTASPSIKLLVDDPIVVNP-------GEAITLVCVTTGGEPAPSLTWVRSFGTLPEK 58
L K+ + IK + I+ P GE+ C T GEP P++TW+R L
Sbjct: 32546 LEEKSTTRKIKTTLAARILTKPRSMTVYEGESARFSC-DTDGEPVPTVTWLRKGQVLSTS 32604
Query: 59 ------TVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRA----------- 101
T T I ++ + D G YS + N+ G + T I +A
Sbjct: 32605 ARHQVTTTKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPP 32664
Query: 102 --------------LKKGRFWITPDPYH---------------KDDNIQIGREVKISCQV 132
+K + +P+P H K ++ + KI+ +
Sbjct: 32665 RVKSPEPRVKSPEAVKSPKRVKSPEPSHPKAVSPTETKPTPTEKVQHLPVSAPPKITQFL 32724
Query: 133 EAVPSEELT---------------FSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIID 177
+A S+E+ +W+K+G+ L+ + + + GT L I +
Sbjct: 32725 KAEASKEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFHYS----ADGTYELKINN 32780
Query: 178 LKFTDFGTYTCVASLKGG------------------GISDIS----IDVNISSSTV---- 211
L +D G Y C S +GG +S IS D + STV
Sbjct: 32781 LTESDQGEYVCEISGEGGTSKTNLQFMGQAFKSIHEKVSKISETKKSDQKTTESTVTRKT 32840
Query: 212 PPNLTVPQEKSPLV-------TREGDTI-ELQCQVTGKPKPIILWSRADKEVAMPDGSMQ 263
P P P++ T D++ + + TG+P+P +W++ K +
Sbjct: 32841 EPKAPEPISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKL 32900
Query: 264 MESYDG-TLRIVNVSREMSGMYRCQTSQYNG 293
E G L I SG+Y C G
Sbjct: 32901 SEDKGGFFLEIHKTDTSDSGLYTCTVKNSAG 32931
Score = 55.1 bits (131), Expect = 2e-07
Identities = 87/389 (22%), Positives = 157/389 (40%), Gaps = 50/389 (12%)
Query: 25 VNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLNGG------TLTIPAITSDDAGT 78
+N G+ + L G A + WV + L G TLTI + D G
Sbjct: 33050 INEGQRLVLKANIAG---ATDVKWVLNGVELTNSEEYRYGVSGSDQTLTIKQASHRDEGI 33106
Query: 79 YSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSE 138
+CI+ G + + + L +I+ + NI G+ V +C++ PS
Sbjct: 33107 LTCISKTKEGIVKCQYDLTLSKELSDAPAFISQP---RSQNINEGQNVLFTCEISGEPSP 33163
Query: 139 ELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGIS 198
E+ WFKN P+ S + I++ S +L+I + +D G YT A G S
Sbjct: 33164 EI--EWFKNNLPISISSNVSISR-----SRNVYSLEIRNASVSDSGKYTIKAKNFRGQCS 33216
Query: 199 DISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMP 258
+S V P + P + L T GDT LQ + + + S + +E +
Sbjct: 33217 ------ATASLMVLPLVEEPSREVVLRT-SGDT-SLQGSFSSQS---VQMSASKQEASFS 33265
Query: 259 DGSMQMESYDGTLRIVNVS-REMSGM----YRCQTSQYNGF-NVKPREALVQLIVQ---- 308
S S ++ ++S + MS M +S + G N+ E+ +++
Sbjct: 33266 SFSSSSASSMTEMKFASMSAQSMSSMQESFVEMSSSSFMGISNMTQLESSTSKMLKAGIR 33325
Query: 309 -YPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRT---GQF---DS 361
PP +E +I + + +T++C P +T W G + + + G+F ++
Sbjct: 33326 GIPPKIEALPSDISIDEGKVLTVAC-AFTGEPTPEVT--WSCGGRKIHSQEQGRFHIENT 33382
Query: 362 QEYTEYAVKSLSNENYGVYNCSIINEAGA 390
+ T + + ++ G+Y S+ NE G+
Sbjct: 33383 DDLTTLIIMDVQKQDGGLYTLSLGNEFGS 33411
Score = 54.7 bits (130), Expect = 3e-07
Identities = 46/183 (25%), Positives = 76/183 (41%), Gaps = 9/183 (4%)
Query: 123 GREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTD 182
G + P E+ SWF++G+ + +S + S G L I + +
Sbjct: 20 GSTATFEAHISGFPVPEV--SWFRDGQVISTS---TLPGVQISFSDGRAKLTIPAVTKAN 74
Query: 183 FGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKP 242
G Y+ A+ G G + + ++ + + T PPN Q + R+G + LQ +VTG P
Sbjct: 75 SGRYSLKAT-NGSGQATSTAELLVKAETAPPNFV--QRLQSMTVRQGSQVRLQVRVTGIP 131
Query: 243 KPIILWSRADKEV-AMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREA 301
P++ + R E+ + D + E +L I E SG Y + G E
Sbjct: 132 TPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGRATSTAEL 191
Query: 302 LVQ 304
LVQ
Sbjct: 192 LVQ 194
Score = 53.5 bits (127), Expect = 7e-07
Identities = 64/285 (22%), Positives = 114/285 (40%), Gaps = 46/285 (16%)
Query: 66 LTIPAITSDDAGTYSCIANNNVGNPAK--KSTNIIVRALKKGRFWITPDPYHKDDNIQIG 123
L IP+ DAG Y+ +A NV + ++ +R++KK +Q+
Sbjct: 3114 LLIPSTRMSDAGKYTVVAGGNVSTAKLFVEGRDVRIRSIKK--------------EVQVI 3159
Query: 124 REVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDF 183
+ + + E V +++ W+K+G + V + V + I + + +D
Sbjct: 3160 EKQRAVVEFE-VNEDDVDAHWYKDGIEINFQ---VQERHKYVVERRIHRMFISETRQSDA 3215
Query: 184 GTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPK 243
G YT VA G S +++ VN PP V QE P+ + G ++G+P+
Sbjct: 3216 GEYTFVA---GRNRSSVTLYVNAPE---PPQ--VLQELQPVTVQSGKPARFCAVISGRPQ 3267
Query: 244 PIILWSRADKEVAMPDGSMQMESYDG---TLRIVNVSREMSGMYRCQTSQYNGFNVKPRE 300
P I W + +E + G +DG TL ++ E + +Y C+ N + V
Sbjct: 3268 PKISWYK--EEQLLSTGFKCKFLHDGQEYTLLLIEAFPEDAAVYTCEAK--NDYGVATTS 3323
Query: 301 ALVQLIVQ-----------YPPAVEPAFLEIRQGQDRSVTMSCRV 334
A + + V YPPA+ + + + CRV
Sbjct: 3324 ASLSVEVPEVVSPDQEMPVYPPAIITPLQDTVTSEGQPARFQCRV 3368
Score = 52.0 bits (123), Expect = 2e-06
Identities = 102/454 (22%), Positives = 179/454 (39%), Gaps = 80/454 (17%)
Query: 67 TIPAITSDDAGTYSCIANNNVG--NPAKKSTNIIVRALKKGRFWITPD---PYHKDDNIQ 121
TI +T+ + + A N G +P + +I R ++ I P P+H N++
Sbjct: 25354 TISGLTAGEEYVFRVAAVNEKGRSDPRQLGVPVIARDIE-----IKPSVELPFHTF-NVK 25407
Query: 122 IGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFT 181
++KI + P + T +W K+G+ L+ + R+ ++ S T+L I +
Sbjct: 25408 AREQLKIDVPFKGRP--QATVNWRKDGQTLKETTRVNVSS-----SKTVTSLSIKEASKE 25460
Query: 182 DFGTYTCVASLKGGGISDISIDVNISSSTVPPN-LTVPQEKSPLVTREGDTIELQ--CQV 238
D GTY S G I+ + I + + PP + + + +T + E CQ+
Sbjct: 25461 DVGTYELCVSNSAGSIT-VPITIIVLDRPGPPGPIRIDEVSCDSITISWNPPEYDGGCQI 25519
Query: 239 TG-----KPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYR-CQTSQYN 292
+ K W + VA +++IV ++ +R C ++Y
Sbjct: 25520 SNYIVEKKETTSTTWHIVSQAVART-----------SIKIVRLTTGSEYQFRVCAENRYG 25568
Query: 293 GFNVKPREALVQLIVQYP--PAVEPAFLEIRQGQDRSVTMSCRV-LRAYPIRVLTYE--- 346
+ A+V +YP P P ++ ++ ++ +V + RV+ Y
Sbjct: 25569 KSSYSESSAVV---AEYPFSPPGPPGTPKVVHATKSTMLVTWQVPVNDGGSRVIGYHLEY 25625
Query: 347 -------WRLGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVTG 399
W NK+L T+ V L Y N AG G+CS
Sbjct: 25626 KERSSILWSKANKILIAD-------TQMKVSGLDEGLMYEYRVYAENIAGIGKCS----- 25673
Query: 400 KAYAPEFYYDTYNPVWQ----NRHRVYSYSLQWTQMNPDAVDRIVAYRLGIRQAGQQRWW 455
K+ P D +P Q N R S SL+W++ + D +I Y + R+ RW
Sbjct: 25674 KSCEPVPARDPCDPPGQPEVTNITRK-SVSLKWSKPHYDGGAKITGYIVERRELPDGRW- 25731
Query: 456 EQEIKIN-GNIQKGELITYNLTELIKPEAYEVRL 488
+K N NIQ+ + +TEL + + YE R+
Sbjct: 25732 ---LKCNYTNIQE---TYFEVTELTEDQRYEFRV 25759
Score = 50.8 bits (120), Expect = 4e-06
Identities = 75/313 (23%), Positives = 121/313 (38%), Gaps = 35/313 (11%)
Query: 189 VASLKGGGISDISIDVNISSSTVPPNLTVPQE------KSPLVTREGDTIELQCQVTGKP 242
V+++ G G D S +V + V LT P+ K V R G +I L G+P
Sbjct: 28328 VSAINGAGKGD-SCEVTGTIKAVD-RLTAPELDIDANFKQTHVVRAGASIRLFIAYQGRP 28385
Query: 243 KPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREAL 302
P +WS+ D +++ +S+ TL + N +R +G Y +G K
Sbjct: 28386 TPTAVWSKPDSNLSLRADIHTTDSF-STLTVENCNRNDAGKYTLTVENNSG--SKSITFT 28442
Query: 303 VQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQ 362
V+++ P F ++ +G + M L R+ Y R+ Q S+
Sbjct: 28443 VKVLDTPGPPGPITFKDVTRGS--ATLMWDAPLLDGGARIHHYVVEKREASRRSWQVISE 28500
Query: 363 EYTE--YAVKSLSNENYGVYNCSIINEAGAGRCSFLVTGKAYAPEFYYDTYNPVWQNRHR 420
+ T + V L+ + S +NE G G PE T P R
Sbjct: 28501 KCTRQIFKVNDLAEGVPYYFRVSAVNEYGVGE-------PYEMPEPIVATEQPAPPRRLD 28553
Query: 421 VYSYS-----LQWTQMNPDAVDRIVAYRLGIRQAGQQRWWEQEIKINGNIQKGELITYNL 475
V S L W + + D RI Y L +RQ G W E G+ ++ +T+ +
Sbjct: 28554 VVDTSKSSAVLAWLKPDHDGGSRITGYLLEMRQKGSDFWVEA-----GHTKQ---LTFTV 28605
Query: 476 TELIKPEAYEVRL 488
L++ YE R+
Sbjct: 28606 ERLVEKTEYEFRV 28618
Score = 47.4 bits (111), Expect = 5e-05
Identities = 42/181 (23%), Positives = 82/181 (45%), Gaps = 14/181 (7%)
Query: 116 KDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTN-LD 174
KD ++G ++SCQ+ P ++ W++ G+ L S + ++ S G T+ L
Sbjct: 30540 KDVTTKLGEAAQLSCQIVGRPLPDI--KWYRFGKELIQSRKYKMS------SDGRTHTLT 30591
Query: 175 IIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIEL 234
++ + D G YTC+A+ + G + S + ++ P + ++ V G T+ L
Sbjct: 30592 VMTEEQEDEGVYTCIATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYGAV---GSTLRL 30648
Query: 235 QCQVTGKPKPIILWSRADKEVAMPDG-SMQMESYDGTLRIVNVSREM-SGMYRCQTSQYN 292
G+P P + W K + + +++ + L + NV R+ +G Y+ Q S
Sbjct: 30649 HVMYIGRPVPAMTWFHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVF 30708
Query: 293 G 293
G
Sbjct: 30709 G 30709
Score = 47.0 bits (110), Expect = 6e-05
Identities = 76/327 (23%), Positives = 123/327 (37%), Gaps = 52/327 (15%)
Query: 211 VPPNLTV-PQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYD- 268
VPP + P+ L+ + G+++ ++ V G+P P + W + E+ + M ME D
Sbjct: 27954 VPPIVEFGPEYFDGLIIKSGESLRIKALVQGRPVPRVTWFKDGVEI---EKRMNMEITDV 28010
Query: 269 ---GTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPP--AVEPAFLEIRQG 323
+L + + +R+ G+Y + +G +A +++ VQ P V P G
Sbjct: 28011 LGSTSLFVRDATRDHRGVYTVEAKNASG----SAKAEIKVKVQDTPGKVVGPIRFTNITG 28066
Query: 324 Q------DRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAVKSLSNENY 377
+ D + C + Y I E R ++L D E Y L N N
Sbjct: 28067 EKMTLWWDAPLNDGCAPITHYII-----EKRETSRLAWALIEDKCEAQSYTAIKLINGNE 28121
Query: 378 GVYNCSIINEAGAGR----------CSFLVTGKAYAPEFYYDTYNPVWQNRHRVYSYSLQ 427
+ S +N+ G GR + V PE T N S +L
Sbjct: 28122 YQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPEPSNITGN----------SITLT 28171
Query: 428 WTQMNPDAVDRIVAYRLGIRQAGQQRWWEQEIKINGNIQKGELITYNLTELIKPEAYEVR 487
W + D I Y L R+ RW +K+ E + +T L + YE
Sbjct: 28172 WARPESDGGSEIQQYILERREKKSTRW----VKVISKRPISE-TRFKVTGLTEGNEYEFH 28226
Query: 488 LTPLTKFGEGDST--IRVIKYSAPVNP 512
+ G G ++ R+IK PVNP
Sbjct: 28227 VMAENAAGVGPASGISRLIKCREPVNP 28253
Score = 46.6 bits (109), Expect = 8e-05
Identities = 71/364 (19%), Positives = 138/364 (37%), Gaps = 56/364 (15%)
Query: 75 DAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEA 134
DAG Y+ +A N + S + V A + + P +Q G+ + +
Sbjct: 3214 DAGEYTFVAGRN-----RSSVTLYVNAPEPPQVLQELQPV----TVQSGKPARFCAVISG 3264
Query: 135 VPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKG 194
P ++ SW+K + L + + + + L +I+ D YTC A
Sbjct: 3265 RPQPKI--SWYKEEQLLSTGFKCKFLHDGQEYT-----LLLIEAFPEDAAVYTCEAK-ND 3316
Query: 195 GGISDISIDVNISSSTV----------PPNLTVPQEKSPLVTREGDTIELQCQVTGKPKP 244
G++ S +++ V PP + P + + VT EG QC+V+G
Sbjct: 3317 YGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQDT--VTSEGQPARFQCRVSGTDLK 3374
Query: 245 IILWSRADKEVAMPDGSMQMESYDGT--LRIVNVSREMSGMYRC-------QTSQYNGFN 295
+ W DK++ P +M ++ T L I E G Y Q S +
Sbjct: 3375 -VSWYSKDKKI-KPSRFFRMTQFEDTYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANLS 3432
Query: 296 VKPREAL--------VQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEW 347
++ E++ +++ ++ P ++ + +C + A +R ++W
Sbjct: 3433 LEAPESILHERIEQEIEMEMKAAPVIKRKIEPLEVALGHLAKFTCEIQSAPNVR---FQW 3489
Query: 348 -RLGNKLLRTGQF---DSQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVT-GKAY 402
+ G ++ + + S+ + + + G Y C NE G+ C+ +T +AY
Sbjct: 3490 FKAGREIYESDKCSIRSSKYISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTVTEAY 3549
Query: 403 APEF 406
P F
Sbjct: 3550 PPTF 3553
Score = 45.1 bits (105), Expect = 2e-04
Identities = 79/399 (19%), Positives = 151/399 (37%), Gaps = 53/399 (13%)
Query: 120 IQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLK 179
++ G ++++ V P ++T W K L+ +R+ I P + + I+D K
Sbjct: 13702 VKAGTKIELPATVTGKPEPKIT--WTKADMILKQDKRITIENV-----PKKSTVTIVDSK 13754
Query: 180 FTDFGTYTCVASLKGGGISDISIDVNISSSTVPP---NLTVPQEKSPLVTREGDTIELQC 236
+D GTY + ++ G + ++VN+ PP ++T +S L+T +
Sbjct: 13755 RSDTGTYI-IEAVNVCGRATAVVEVNVLDKPGPPAAFDITDVTNESCLLTWNPPRDDGGS 13813
Query: 237 QVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNV 296
++T ++ D EV + D + + ++R G
Sbjct: 13814 KITNY---VVERRATDSEVWH---KLSSTVKDTNFKATKLIPNKEYIFRVAAENMYGVGE 13867
Query: 297 KPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMS-CRV-------LRAYPIRVL---TY 345
+ + + Q+ P P LE +VT++ C + Y + L T
Sbjct: 13868 PVQASPITAKYQFDPPGPPTRLEPSDITKDAVTLTWCEPDDDGGSPITGYWVERLDPDTD 13927
Query: 346 EWRLGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVTGKAYAPE 405
+W NK+ + T Y VK L+N+ + N AG G+ S K+ P
Sbjct: 13928 KWVRCNKM-------PVKDTTYRVKGLTNKKKYRFRVLAENLAGPGKPS-----KSTEPI 13975
Query: 406 FYYDTYNPVWQNRHRVY------SYSLQWTQMNPDAVDRIVAYRLGIRQAGQQRWWEQEI 459
D +P W S L WT+ D +I +Y + + + G W +
Sbjct: 13976 LIKDPIDPPWPPGKPTVKDVGKTSVRLNWTKPEHDGGAKIESYVIEMLKTGTDEW----V 14031
Query: 460 KINGNIQKGELITYNLTELIKPEAYEVRLTPLTKFGEGD 498
++ + + + L L++ + Y R+ + K GE +
Sbjct: 14032 RVAEGVPTTQ---HLLPGLMEGQEYSFRVRAVNKAGESE 14067
Score = 44.3 bits (103), Expect = 4e-04
Identities = 72/309 (23%), Positives = 126/309 (40%), Gaps = 72/309 (23%)
Query: 66 LTIPAITSDDAGTYSCIA-------NNNVGNP----AKKSTNIIVRALKKGRFWITPDPY 114
L I T +D TY+C A N NV P + T++ VR + RF
Sbjct: 12341 LVIHDCTPEDIKTYTCDAKDFKTSCNLNVVPPHVEFLRPLTDLQVREKEMARF------- 12393
Query: 115 HKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLD 174
C++ E WFK+G ++ ++ I +S G +
Sbjct: 12394 --------------ECELSR---ENAKVKWFKDGAEIKKGKKYDI------ISKGAVRIL 12430
Query: 175 IID-LKFTDFGTYTC-VASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTI 232
+I+ D Y+C V + + G+ + + + + + N+ V E DTI
Sbjct: 12431 VINKCLLDDEAEYSCEVRTARTSGMLTVLEEEAVFTKNLA-NIEVS---------ETDTI 12480
Query: 233 ELQCQVTGKPKPIILWSRADKEVAMPDGSMQM--ESYDGTLRIVNVSREMSGMYRCQ--T 288
+L C+V+ KP ++W + D+E+ + G ++ E L I N E +G Y C+ +
Sbjct: 12481 KLVCEVS-KPGAEVIWYKGDEEI-IETGRYEILTEGRKRILVIQNAHLEDAGNYNCRLPS 12538
Query: 289 SQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWR 348
S+ +G VK E + I +P LEI +G+ S ++P+ +W+
Sbjct: 12539 SRTDG-KVKVHELAAEFI------SKPQNLEILEGEKAEFVCSIS-KESFPV-----QWK 12585
Query: 349 LGNKLLRTG 357
+K L +G
Sbjct: 12586 RDDKTLESG 12594
Score = 43.9 bits (102), Expect = 5e-04
Identities = 51/226 (22%), Positives = 88/226 (38%), Gaps = 30/226 (13%)
Query: 22 PIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLN----GGT--LTIPAITSDD 75
P+ V+ GE + L C G EP + W+++ + + GT L + + D
Sbjct: 8354 PVTVSEGEYVQLSCHVQGSEPI-RIQWLKAGREIKPSDRCSFSFASGTAVLELRDVAKAD 8412
Query: 76 AGTYSCIANNNVGNPAKKSTNIIV----------RALKKGRFWITPDPYHKDDNIQIGRE 125
+G Y C A+N G+ KS I +A GR + +P +I++ +
Sbjct: 8413 SGDYVCKASNVAGSDTTKSKVTIKDKPAVAPATKKAAVDGRLFFVSEP----QSIRVVEK 8468
Query: 126 VKISCQVEAVPSEELTFSWFKNG-RPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFG 184
+ + W K R L R+ I Q + L+I D TD G
Sbjct: 8469 TTATFIAKVGGDPIPNVKWTKGKWRQLNQGGRVFIHQKGDEAK-----LEIRDTTKTDSG 8523
Query: 185 TYTCVASLKGGGIS---DISIDVNISSSTVPPNLTVPQEKSPLVTR 227
Y CVA + G I ++ +D + +L +K+P++ +
Sbjct: 8524 LYRCVAFNEHGEIESNVNLQVDERKKQEKIEGDLRAMLKKTPILKK 8569
Score = 43.5 bits (101), Expect = 7e-04
Identities = 41/158 (25%), Positives = 71/158 (44%), Gaps = 14/158 (8%)
Query: 12 SPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPE----KTVLNGGTLT 67
+P I+ + D + GEA L C G P P + W R L + K +G T T
Sbjct: 30532 APGIRKEMKD-VTTKLGEAAQLSCQIVG-RPLPDIKWYRFGKELIQSRKYKMSSDGRTHT 30589
Query: 68 IPAITSD--DAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGRE 125
+ +T + D G Y+CIA N VG + S+ ++++A + + P + +G
Sbjct: 30590 LTVMTEEQEDEGVYTCIATNEVGE-VETSSKLLLQATPQ---FHPGYPLKEKYYGAVGST 30645
Query: 126 VKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTD 163
+++ P +T WF + L++SE + I T+
Sbjct: 30646 LRLHVMYIGRPVPAMT--WFHGQKLLQNSENITIENTE 30681
Score = 42.4 bits (98), Expect = 0.002
Identities = 28/99 (28%), Positives = 46/99 (46%), Gaps = 3/99 (3%)
Query: 198 SDISIDVNISSSTVPPNLTV-PQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVA 256
SD S + PN ++ P+ K +V G+T L+ + GKP P ++WS+ KE+
Sbjct: 24690 SDSSGAITARDEIDAPNASLDPKYKDVIVVHAGETFVLEADIRGKPIPDVVWSKDGKELE 24749
Query: 257 MPDGSMQMES--YDGTLRIVNVSREMSGMYRCQTSQYNG 293
M+++S TL + + R G Y + S G
Sbjct: 24750 ETAARMEIKSTIQKTTLVVKDCIRTDGGQYILKLSNVGG 24788
Score = 42.0 bits (97), Expect = 0.002
Identities = 28/99 (28%), Positives = 49/99 (49%), Gaps = 9/99 (9%)
Query: 6 LSNKTASPSIKL--LVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLN- 62
+ ++ SP ++L V D IVV+ G I ++ +G +P P++TW + TLP++ +
Sbjct: 16515 MKDRLVSPDLQLDASVRDRIVVHAGGVIRIIAYVSG-KPPPTVTWNMNERTLPQEATIET 16573
Query: 63 ---GGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNII 98
++ I G YS +A N G +K T I+
Sbjct: 16574 TAISSSMVIKNCQRSHQGVYSLLAKNEAGE--RKKTIIV 16610
Score = 41.6 bits (96), Expect = 0.003
Identities = 74/363 (20%), Positives = 128/363 (35%), Gaps = 30/363 (8%)
Query: 174 DIIDLKFTDFGT-------YTCVASLKGGGIS---DISIDVNISSSTVPPNLTV-PQEKS 222
++I+ +FT G + +A G IS D + + P +++ P+ +
Sbjct: 23574 NVIETQFTVSGLTEDQRYEFRVIAKNAAGAISKPSDSTGPITAKDEVELPRISMDPKFRD 23633
Query: 223 PLVTREGDTIELQCQVTGKPKPIILWSRADKEV-AMPDGSMQMESYDGTLRIVNVSREMS 281
+V G+T L+ V GKP P I W R DKE+ ++ + L + + R
Sbjct: 23634 TIVVNAGETFRLEADVHGKPLPTIEWLRGDKEIEESARCEIKNTDFKALLIVKDAIRIDG 23693
Query: 282 GMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVL-RAYPI 340
G Y + S G P V+++ + P P + + S+T S + I
Sbjct: 23694 GQYILRASNVAGSKSFP--VNVKVLDRPGPPEGPVQVTGVTSEKCSLTWSPPLQDGGSDI 23751
Query: 341 RVLTYEWRLGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVTGK 400
E R ++L T V L N V+ +N+ G G
Sbjct: 23752 SHYVVEKRETSRLAWTVVASEVVTNSLKVTKLLEGNEYVFRIMAVNKYGVGEPLESAPVL 23811
Query: 401 AYAPEFYYDTYNPVWQNRHRVYSYSLQWTQMNPDAVDRIVAYRLGIRQAGQQRWWEQEIK 460
P + S ++ W + + D I+ Y + R RW
Sbjct: 23812 MKNPFVLPGPPKSLEVTNIAKDSMTVCWNRPDSDGGSEIIGYIVEKRDRSGIRW------ 23865
Query: 461 INGNIQKGELITYNLTELIKPEAYEVRLTPLTKFGEGDSTIRVIKYSA---------PVN 511
I N ++ + +T L + YE R++ G G+ + + Y A P N
Sbjct: 23866 IKCNKRRITDLRLRVTGLTEDHEYEFRVSAENAAGVGEPSPATVYYKACDPVFKPGPPTN 23925
Query: 512 PHL 514
H+
Sbjct: 23926 AHI 23928
Score = 41.2 bits (95), Expect = 0.003
Identities = 68/342 (19%), Positives = 131/342 (38%), Gaps = 62/342 (18%)
Query: 65 TLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHK---DDNIQ 121
TLT+ + +DAG A + K N+ V+ P + K D ++
Sbjct: 12251 TLTLRDVKLEDAGEVQLTAKD-----FKTHANLFVKE--------PPVEFTKPLEDQTVE 12297
Query: 122 IGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPG-TTNLDIIDLKF 180
G + C+V E WFKNG + S++ I V+ G L I D
Sbjct: 12298 EGATAVLECEVSR---ENAKVKWFKNGTEILKSKKYEI------VADGRVRKLVIHDCTP 12348
Query: 181 TDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTG 240
D TYTC A D N+ + VPP++ + + L RE + +C+++
Sbjct: 12349 EDIKTYTCDA-------KDFKTSCNL--NVVPPHVEFLRPLTDLQVREKEMARFECELS- 12398
Query: 241 KPKPIILWSRADKEVAMPDGSMQMESYD----GTLRIVNVSR---EMSGMYRCQTSQYNG 293
+ + W + E+ + + YD G +RI+ +++ + Y C+
Sbjct: 12399 RENAKVKWFKDGAEI------KKGKKYDIISKGAVRILVINKCLLDDEAEYSCEVR---- 12448
Query: 294 FNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKL 353
R + + +++ I + ++ + C V + V+ Y+ ++
Sbjct: 12449 ---TARTSGMLTVLEEEAVFTKNLANIEVSETDTIKLVCEVSKP-GAEVIWYKG--DEEI 12502
Query: 354 LRTGQFDSQEYTEYAVKSLSN---ENYGVYNCSIINEAGAGR 392
+ TG+++ + + N E+ G YNC + + G+
Sbjct: 12503 IETGRYEILTEGRKRILVIQNAHLEDAGNYNCRLPSSRTDGK 12544
Score = 41.2 bits (95), Expect = 0.003
Identities = 79/368 (21%), Positives = 142/368 (38%), Gaps = 69/368 (18%)
Query: 174 DIIDLKFT-----DFGTYTC-VASLKGGGISDISIDV---NISSSTVPPNLTVPQEKSPL 224
D+ +L+FT + G Y V ++ G+S S V + +PP++ + K +
Sbjct: 16070 DVEELQFTVEDLVEGGEYEFRVKAVNAAGVSKPSATVGPCDCQRPDMPPSIDL---KEFM 16126
Query: 225 VTREGDTIELQCQVTGKPKPIILWSRA------DKEVAMPDGSMQMESYDGTLRIV--NV 276
EG + + ++ G P P + W +A +KE + D + D T +V
Sbjct: 16127 EVEEGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDTCTLVIPQS 16186
Query: 277 SREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLR 336
R +G+Y + N +E + ++ + P V P E SV+ L
Sbjct: 16187 RRSDTGLY--TITAVNNLGTASKEMRLNVLGRPGPPVGPIKFE-------SVSADQMTLS 16237
Query: 337 AYP--------IRVLTYEWRLGNKLLRTGQFDSQE-----YT--------EYAVKSLSNE 375
+P I E R N+ +T S E YT EY + ++
Sbjct: 16238 WFPPKDDGGSKITNYVIEKREANR--KTWVHVSSEPKECTYTIPKLLEGHEYVFRIMAQN 16295
Query: 376 NYGVYNCSIINEAGAGRCSFLVTGKAYAPEFYYDTYNPVWQNRHRVYSYSLQWTQMNPDA 435
YG+ + +E R F V G P T + V +N S ++ W + D
Sbjct: 16296 KYGIGE-PLDSEPETARNLFSVPGAPDKP-----TVSSVTRN-----SMTVNWEEPEYDG 16344
Query: 436 VDRIVAYRLGIRQAGQQRWWEQEIKINGNIQKGEL--ITYNLTELIKPEAYEVRLTPLTK 493
+ Y L ++ +RW ++N + K ++Y +T LI+ Y+ R+ +
Sbjct: 16345 GSPVTGYWLEMKDTTSKRW----KRVNRDPIKAMTLGVSYKVTGLIEGSDYQFRVYAINA 16400
Query: 494 FGEGDSTI 501
G G +++
Sbjct: 16401 AGVGPASL 16408
Score = 41.2 bits (95), Expect = 0.003
Identities = 36/127 (28%), Positives = 58/127 (45%), Gaps = 7/127 (5%)
Query: 198 SDISIDVNISSSTVPPNLTVPQE-KSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVA 256
S+ S V I + VPP + + KS L + G + L V GKP P + W + +
Sbjct: 19278 SEPSDPVTILAENVPPRIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKKDGTLLK 19337
Query: 257 MPDG-SMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEP 315
+G M M+ TL + +V+R+ SG Y +G + A ++L V P P
Sbjct: 19338 PAEGIKMAMQRNLCTLELFSVNRKDSGDYTITAENSSG----SKSATIKLKVLDKPG-PP 19392
Query: 316 AFLEIRQ 322
A ++I +
Sbjct: 19393 ASVKINK 19399
Score = 40.8 bits (94), Expect = 0.004
Identities = 50/205 (24%), Positives = 84/205 (40%), Gaps = 15/205 (7%)
Query: 209 STVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVA---MPDGSMQME 265
+T P T P + +V EG T + ++G P P + W R + ++ +P +
Sbjct: 2 TTQAPTFTQPLQS--VVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFS 59
Query: 266 SYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEP-AFLEIRQGQ 324
L I V++ SG Y + + +G E LV+ P V+ + +RQG
Sbjct: 60 DGRAKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGS 119
Query: 325 DRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFD-SQEYTEYA--VKSLSNENYGVYN 381
V + RV P V+ + +R G ++ + F SQE Y+ + E+ G Y+
Sbjct: 120 --QVRLQVRV-TGIPTPVVKF-YRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYS 175
Query: 382 CSIINEAG--AGRCSFLVTGKAYAP 404
+ N G LV G+ P
Sbjct: 176 VNATNSVGRATSTAELLVQGEEEVP 200
Score = 40.8 bits (94), Expect = 0.004
Identities = 42/160 (26%), Positives = 73/160 (45%), Gaps = 19/160 (11%)
Query: 40 GEPAPSLTWVR-----SFGTLPEKTVL---NGGTLTIPAITSDDAGTYSCIANNNVGNPA 91
G P P ++W R S TLP + LTIPA+T ++G YS A N G A
Sbjct: 31 GFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVTKANSGRYSLKATNGSGQ-A 89
Query: 92 KKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPL 151
+ ++V+A ++ + ++ G +V++ +V +P+ + F +++G +
Sbjct: 90 TSTAELLVKAETAPPNFV---QRLQSMTVRQGSQVRLQVRVTGIPTPVVKF--YRDGAEI 144
Query: 152 RSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVAS 191
+SS I+Q S L I + D GTY+ A+
Sbjct: 145 QSSLDFQISQEGDLYS-----LLIAEAYPEDSGTYSVNAT 179
Score = 40.8 bits (94), Expect = 0.004
Identities = 34/137 (24%), Positives = 66/137 (48%), Gaps = 10/137 (7%)
Query: 123 GREVKISCQVEAVPSEELTFSWFKNGRPLRSS-ERMVITQTDPDVSPGTTNLDIIDLKFT 181
G+ + +V P E TF WF +G+ + + V+ + D GT +L I+ +
Sbjct: 1471 GQTARFDLKVVGRPMPE-TF-WFHDGQQIVNDYTHKVVIKED-----GTQSLIIVPATPS 1523
Query: 182 DFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGK 241
D G +T VA + G S IS+ + + + ++ + +EG +E++ + TG
Sbjct: 1524 DSGEWTVVAQNRAGR-SSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSRLEMKVRATGN 1582
Query: 242 PKPIILWSRADKEVAMP 258
P P I+W + + ++ +P
Sbjct: 1583 PNPDIVWLK-NSDIIVP 1598
Score = 40.4 bits (93), Expect = 0.006
Identities = 71/331 (21%), Positives = 122/331 (36%), Gaps = 31/331 (9%)
Query: 196 GISDISIDVNISSSTVPPNLTVPQE-------KSPLVTREGDTIELQCQVTGKPKPIILW 248
G SD S ++ P ++ +P E + L+ R G T+ L V G+P P I W
Sbjct: 19671 GYSDPS---DVPDKHYPKDILIPPEGELDADLRKTLILRAGVTMRLYVPVKGRPPPKITW 19727
Query: 249 SRADKEVAMPDG-SMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIV 307
S+ + + G ++ +D LR NV++ +G Y N K +V+++
Sbjct: 19728 SKPNVNLRDRIGLDIKSTDFDTFLRCENVNKYDAGKYILTLE--NSCGKKEYTIVVKVLD 19785
Query: 308 QYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEY 367
P V EI + + PI + R + + T +
Sbjct: 19786 TPGPPVNVTVKEISKDSAYVTWEPPIIDGGSPIINYVVQKRDAERKSWSTVTTECSKTSF 19845
Query: 368 AVKSLSNENYGVYNCSIINEAGAGRCSFLVTGKAYAPEFYYDTYNPVWQNRHRVY---SY 424
V +L + NE G G G+ T PV + R S
Sbjct: 19846 RVANLEEGKSYFFRVFAENEYGIGD-----PGETRDAVKASQTPGPVVDLKVRSVSKSSC 19900
Query: 425 SLQWTQMNPDAVDRIVAYRLGIRQAGQQRWWEQEIKINGNIQKGELITYNLTELIKPEAY 484
S+ W + + D RI+ Y + ++ W++ + K + Y+ +L + + Y
Sbjct: 19901 SIGWKKPHSDGGSRIIGYVVDF--LTEENKWQR-------VMKSLSLQYSAKDLTEGKEY 19951
Query: 485 EVRLTPLTKFGEG-DSTIRVIKYSAPVNPHL 514
R++ + GEG S I V+ V P L
Sbjct: 19952 TFRVSAENENGEGTPSEITVVARDDVVAPDL 19982
Score = 40.4 bits (93), Expect = 0.006
Identities = 61/333 (18%), Positives = 116/333 (34%), Gaps = 48/333 (14%)
Query: 7 SNKTASPSIKLLVDDPIVVNPGEAITL--------------VCVTTGGEPAPSLTWVRSF 52
+ KT+ ++L P ++ ITL + +P + W +
Sbjct: 32352 TQKTSERKYEVLSQQPFTLDHAPRITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWYHNG 32411
Query: 53 GTLPEKTVLN----GGTLTIPAIT--SDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGR 106
L E + ++ G LT+ + +DD+GTY + N G + +T + G
Sbjct: 32412 VELQESSKIHYTNTSGVLTLEILDCHTDDSGTYRAVCTNYKGEASDYATLDVT-----GG 32466
Query: 107 FWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDV 166
+ T +D+ EV S E +E S FK + +S + + +
Sbjct: 32467 DYTTYASQRRDE------EVPRSVFPELTRTEAYAVSSFKKTSEMEASSS--VREVKSQM 32518
Query: 167 SPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSP--L 224
+ +L + ++ A +K + + S++ ++ + L P +
Sbjct: 32519 TETRESLSSYE--------HSASAEMKSAALEEKSLEEKSTTRKIKTTLAARILTKPRSM 32570
Query: 225 VTREGDTIELQCQVTGKPKPIILWSRADKEVA-MPDGSMQMESYDGTLRIVNVSREMSGM 283
EG++ C G+P P + W R + ++ + Y T I +V G
Sbjct: 32571 TVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKSTFEISSVQASDEGN 32630
Query: 284 YRCQTSQYNGFNVKPREALVQLIVQYPPAVEPA 316
Y G +EA L +Q E A
Sbjct: 32631 YSVVVENSEG----KQEAEFTLTIQKARVTEKA 32659
Score = 40.0 bits (92), Expect = 0.008
Identities = 29/128 (22%), Positives = 54/128 (42%), Gaps = 5/128 (3%)
Query: 171 TNLDIIDLKFTDFGTYTC---VASLKGGGISDISIDVNISSSTVPPNLTVPQEK-SPLVT 226
TNL+ + TY ++ G G+ D +I + VPP++ + + LV
Sbjct: 17463 TNLECVVTGLQQGKTYRFRVKAENIVGLGLPDTTIPIECQEKLVPPSVELDVKLIEGLVV 17522
Query: 227 REGDTIELQCQVTGKPKPIILWSRADKEVAMPDG-SMQMESYDGTLRIVNVSREMSGMYR 285
+ G T+ + G P P W+ E+ + +++ +++ L I N R +G Y+
Sbjct: 17523 KAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTDEHYTVETDNFSSVLTIKNCLRRDTGEYQ 17582
Query: 286 CQTSQYNG 293
S G
Sbjct: 17583 ITVSNAAG 17590
Score = 40.0 bits (92), Expect = 0.008
Identities = 26/86 (30%), Positives = 42/86 (48%), Gaps = 9/86 (10%)
Query: 23 IVVNPGEAITLVCVTTGGEPAPSLTW---VRSFGTLPEKTVLN---GGTLTIPAITSDDA 76
++ GE + V + G P P++TW ++ G+ ++ N LTIP +T +D
Sbjct: 27281 VIAKAGEDVQ-VLIPFKGRPPPTVTWRKDEKNLGSDARYSIENTDSSSLLTIPQVTRNDT 27339
Query: 77 GTYSCIANNNVGNPAKKSTNIIVRAL 102
G Y N VG P KS+ + V+ L
Sbjct: 27340 GKYILTIENGVGEP--KSSTVSVKVL 27363
Score = 39.3 bits (90), Expect = 0.013
Identities = 72/323 (22%), Positives = 118/323 (36%), Gaps = 45/323 (13%)
Query: 218 PQEKSPLVTREGDTIELQC-QVTGKPKPIILWSRADKEVAMPDGSMQMES--YDGTLRIV 274
P K L + GDTI L + GKP P WS+A K++ P Q+ S L I
Sbjct: 20382 PTIKDGLTIKAGDTIVLNAISILGKPLPKSSWSKAGKDI-RPSDITQITSTPTSSMLTIK 20440
Query: 275 NVSREMSGMYRCQTSQYNGFNVKPREALVQLI-VQYPPAVEPAFLEIRQGQDRSVTMSCR 333
+R+ +G Y + N F K V ++ V PP P + + ++T +
Sbjct: 20441 YATRKDAGEYTITAT--NPFGTKVEHVKVTVLDVPGPPG--PVEISNVSAEKATLTWTPP 20496
Query: 334 VL-RAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGR 392
+ PI+ E R ++LL T + + + L N ++ S +N G G
Sbjct: 20497 LEDGGSPIKSYILEKRETSRLLWTVVSEDIQSCRHVATKLIQGNEYIFRVSAVNHYGKGE 20556
Query: 393 ----------CSFLVTGKAYAPEFYYDTYNPVWQNRHRVYSYSLQWTQMNPDAVDRIVAY 442
F G PE T N + ++ W + D I Y
Sbjct: 20557 PVQSEPVKMVDRFGPPGPPEKPEVSNVTKN----------TATVSWKRPVDDGGSEITGY 20606
Query: 443 RLGIRQAGQQRWWEQEIKINGNIQKGELITYNLTELIKPEAYEVRLTPLTKFGEG---DS 499
+ R+ RW + + +T L + YE R++ + G G ++
Sbjct: 20607 HVERREKKSLRW------VRAIKTPVSDLRCKVTGLQEGSTYEFRVSAENRAGIGPPSEA 20660
Query: 500 TIRVIKYSA------PVNPHLRE 516
+ V+ A P NPH+ +
Sbjct: 20661 SDSVLMKDAAYPPGPPSNPHVTD 20683
Score = 39.3 bits (90), Expect = 0.013
Identities = 54/248 (21%), Positives = 87/248 (35%), Gaps = 33/248 (13%)
Query: 221 KSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGT------LRIV 274
+ L+ + G + + G+P P +LWS+ PD ++ +Y T L I
Sbjct: 26193 RKTLIVKAGASFTMTVPFRGRPVPNVLWSK-------PDTDLRTRAYVDTTDSRTSLTIE 26245
Query: 275 NVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRV 334
N +R SG Y NV +L ++ P + ++ S +S V
Sbjct: 26246 NANRNDSGKYTLTIQ-----NVLSAASLTLVVKVLDTPGPPTNITVQDVTKESAVLSWDV 26300
Query: 335 LR---AYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAG 391
P++ E R +K ++ Y V +L + S NE G G
Sbjct: 26301 PENDGGAPVKNYHIEKREASKKAWVSVTNNCNRLSYKVTNLQEGAIYYFRVSGENEFGVG 26360
Query: 392 -----RCSFLVTGKAYAPEFYYDTYNPVWQNRHRVYSYSLQWTQMNPDAVDRIVAYRLGI 446
+ +T K PE + S SL W + D RIV Y +
Sbjct: 26361 IPAETKEGVKITEKPSPPE-------KLGVTSISKDSVSLTWLKPEHDGGSRIVHYVVEA 26413
Query: 447 RQAGQQRW 454
+ GQ+ W
Sbjct: 26414 LEKGQKNW 26421
Score = 38.9 bits (89), Expect = 0.017
Identities = 90/420 (21%), Positives = 152/420 (36%), Gaps = 57/420 (13%)
Query: 211 VPPNLTVPQEKSPLVT-REGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDG 269
+PP + + + +VT R T+ L + G+P P + W+R D ++ S++ S
Sbjct: 21856 LPPEIELDADLRKVVTIRACCTLRLFVPIKGRPAPEVKWAR-DHGESLDKASIESTSSYT 21914
Query: 270 TLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVT 329
L + NV+R SG Y +G + A V + V P P L++++ SVT
Sbjct: 21915 LLIVGNVNRFDSGKYILTVENSSG----SKSAFVNVRVLDTPG-PPQDLKVKEVTKTSVT 21969
Query: 330 MSC--------RVLRAYPIRV-----LTYEWRLGNKLLRTGQFDS-QEYTEYAVKSLSNE 375
++ ++ Y + Y N + + D QE Y + L+
Sbjct: 21970 LTWDPPLLDGGSKIKNYIVEKRESTRKAYSTVATNCHKTSWKVDQLQEGCSYYFRVLAEN 22029
Query: 376 NYGVYNCSIINEAGAGRCSFLVTGKAYAPEFYYDTYNPVWQNRHRVYSYSLQWTQMNPDA 435
YG+ + E+ L GK T V +N S SL W + D
Sbjct: 22030 EYGIGLPAETAESVKASERPLPPGKI--------TLMDVTRN-----SVSLSWEKPEHDG 22076
Query: 436 VDRIVAYRLGIRQAGQQRWWEQEIKINGNIQKGELITYNLTELIKPEAYEVRLTPLTKFG 495
RI+ Y + ++ G +W ++ +T LI+ E Y R++ + G
Sbjct: 22077 GSRILGYIVEMQTKGSDKW--------ATCATVKVTEATITGLIQGEEYSFRVSAQNEKG 22128
Query: 496 EGDS---TIRVIKYSAPVNPHLREFHCGF-----EDGNICL-FTQDDTDNFDWTK----- 541
D ++ VI + P + F ED + + F T W K
Sbjct: 22129 ISDPRQLSVPVIAKDLVIPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPL 22188
Query: 542 QSTATRNTKYTPNTGPNADRSGSKEGFYMYIETSRPRLEGEKARLLSPVFSIAPKNPYGP 601
+ T N + T N + +E Y+ GE L+ + P P GP
Sbjct: 22189 KQTTRVNAESTENNSLLTIKDACREDVGHYV-VKLTNSAGEAIETLNVIVLDKPGPPTGP 22247
Score = 38.9 bits (89), Expect = 0.017
Identities = 28/95 (29%), Positives = 46/95 (48%), Gaps = 8/95 (8%)
Query: 119 NIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDL 178
+IQ G ++KI V P + SW K+G PL+ + R+ + +T +T L I +
Sbjct: 24322 SIQAGEDLKIEIPVIGRPRPNI--SWVKDGEPLKQTTRVNVEET-----ATSTVLHIKEG 24374
Query: 179 KFTDFGTYTCVASLKGGGISDISIDVNISSSTVPP 213
DFG YT A+ G ++ ++ V + PP
Sbjct: 24375 NKDDFGKYTVTATNSAGTATE-NLSVIVLEKPGPP 24408
Score = 38.9 bits (89), Expect = 0.017
Identities = 38/153 (24%), Positives = 68/153 (44%), Gaps = 8/153 (5%)
Query: 181 TDFGTYTCVASLKG-GGISDISIDVNISSSTVPPNLTVPQE-KSPLVTREGDTIELQCQV 238
T++ C + +G G + + V PP + + + + +V R T+ L +
Sbjct: 25072 TEYNFRICAINSEGVGEPATLPGSVVAQERIEPPEIELDADLRKVVVLRASATLRLFVTI 25131
Query: 239 TGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKP 298
G+P+P + W +A+ + +++ S L I NV+R SG Y +G
Sbjct: 25132 KGRPEPEVKWEKAE-GILTDRAQIEVTSSFTMLVIDNVTRFDSGRYNLTLENNSG----S 25186
Query: 299 REALVQLIVQYPPAVEPAFLEIRQGQDRSVTMS 331
+ A V + V P+ P L IR+ + SVT+S
Sbjct: 25187 KTAFVNVRVLDSPSA-PVNLTIREVKKDSVTLS 25218
Score = 38.9 bits (89), Expect = 0.017
Identities = 63/291 (21%), Positives = 107/291 (36%), Gaps = 37/291 (12%)
Query: 224 LVT-REGDTIELQCQVTGKPKPIILWSRADKEVAMPDG-SMQMESYDGTLRIVNVSREMS 281
LVT R G + L V GKP+P I+W++ DKE+ + + S+Q T I R S
Sbjct: 29056 LVTIRAGSDLVLDAAVGGKPEPKIIWTKGDKELDLCEKVSLQYTGKRATAVIKFCDRSDS 29115
Query: 282 GMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIR 341
G Y +G K +V+++ P + + Q + + I
Sbjct: 29116 GKYTLTVKNASG--TKAVSVMVKVLDSPGPCGKLTVSRVTQEKCTLAWSLPQEDGGAEIT 29173
Query: 342 VLTYEWRLGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAG---------- 391
E R ++L Y V L N ++ +N+ G G
Sbjct: 29174 HYIVERRETSRLNWVIVEGECPTLSYVVTRLIKNNEYIFRVRAVNKYGPGVPVESEPIVA 29233
Query: 392 RCSFLVTGKAYAPEFYYDTYNPVWQNRHRVYSYSLQWTQMNPDAVDRIVAYRLGIRQAGQ 451
R SF + PE V + + +QWT+ D + I Y + R+
Sbjct: 29234 RNSFTIPSPPGIPE-------EVGTGKEHII---IQWTKPESDGGNEISNYLVDKREKKS 29283
Query: 452 QRWWEQEIKINGNIQKGELITYN----LTELIKPEAYEVRLTPLTKFGEGD 498
RW ++N + + Y+ +T L++ Y+ R+T + G +
Sbjct: 29284 LRW----TRVN-----KDYVVYDTRLKVTSLMEGCDYQFRVTAVNAAGNSE 29325
Score = 38.9 bits (89), Expect = 0.017
Identities = 26/96 (27%), Positives = 43/96 (44%), Gaps = 10/96 (10%)
Query: 208 SSTVPPNLTVP-------QEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDG 260
S + P VP +E L R L C+VTG PKPI+ W R KE+
Sbjct: 30914 SEPITPKSDVPIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGL 30973
Query: 261 SMQMESYDG---TLRIVNVSREMSGMYRCQTSQYNG 293
+++ + G L I +V+ + + +Y+ + + G
Sbjct: 30974 KYRIQEFKGGYHQLIIASVTDDDATVYQVRATNQGG 31009
Score = 38.5 bits (88), Expect = 0.022
Identities = 23/87 (26%), Positives = 41/87 (47%), Gaps = 8/87 (9%)
Query: 208 SSTVPPNLTVPQEKSPLVTR-------EGDTIELQCQVTGKPKPIILWSRADKEV-AMPD 259
++ VP + +P LV+ EG+++ L+C ++G P P + W R D ++ + D
Sbjct: 929 TARVPAPVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSID 988
Query: 260 GSMQMESYDGTLRIVNVSREMSGMYRC 286
+ +S L I E SG + C
Sbjct: 989 FQITFQSGIARLMIREAFAEDSGRFTC 1015
Score = 38.5 bits (88), Expect = 0.022
Identities = 23/63 (36%), Positives = 34/63 (53%), Gaps = 3/63 (4%)
Query: 224 LVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESY--DGTLRIVNVSREMS 281
L + G IEL VTGKP+P I W++AD + D + +E+ T+ IV+ R +
Sbjct: 13700 LTVKAGTKIELPATVTGKPEPKITWTKADM-ILKQDKRITIENVPKKSTVTIVDSKRSDT 13758
Query: 282 GMY 284
G Y
Sbjct: 13759 GTY 13761
Score = 38.5 bits (88), Expect = 0.022
Identities = 38/124 (30%), Positives = 51/124 (41%), Gaps = 24/124 (19%)
Query: 23 IVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLNGGT--------LTIPAITSD 74
++V G I L + G PAP +TW R G + V G L IP T D
Sbjct: 18616 VIVRAGCPIRLFAIVRG-RPAPKVTW-RKVGI--DNVVRKGQVDLVDTMAFLVIPNSTRD 18671
Query: 75 DAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEA 134
D+G YS N G +K+ + VR L TP P ++++ K SC V
Sbjct: 18672 DSGKYSLTLVNPAG---EKAVFVNVRVLD------TPGPV---SDLKVSDVTKTSCHVSW 18719
Query: 135 VPSE 138
P E
Sbjct: 18720 APPE 18723
Score = 38.1 bits (87), Expect = 0.029
Identities = 39/168 (23%), Positives = 74/168 (44%), Gaps = 11/168 (6%)
Query: 171 TNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVN----ISSSTVPPNLTVPQEKSPLVT 226
T + DLK ++ VA++ G+S+ S + + +P K +
Sbjct: 29400 TEFTVPDLKMGQKYSFR-VAAVNVKGMSEYSESIAEIEPVERIEIPDLELADDLKKTVTI 29458
Query: 227 REGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRC 286
R G ++ L V+G+P P+I WS+ ++A ESY L + V+R +G Y
Sbjct: 29459 RAGASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDTTESY-SLLIVDKVNRYDAGKYTI 29517
Query: 287 QTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRV 334
+ +G + A V + V P P+ +++++ SVT++ +
Sbjct: 29518 EAENQSG----KKSATVLVKVYDTPGPCPS-VKVKEVSRDSVTITWEI 29560
Score = 38.1 bits (87), Expect = 0.029
Identities = 64/299 (21%), Positives = 111/299 (37%), Gaps = 38/299 (12%)
Query: 28 GEAITLVCVTTGGEPAPSLTWVRSFGTLP-----EKTVLNG-GTLTIPAITSDDAGTYSC 81
G + VC + + +TW L E T +G L + IT D GTY C
Sbjct: 31582 GGHVKYVCKIENYDQSTQVTWYFGVRQLENSEKYEITYEDGVAILYVKDITKLDDGTYRC 31641
Query: 82 IANNNVGNPA------------------KKSTNIIVRALKKGRFWITPDPYHK---DDNI 120
N+ G + +++ I R R P + +
Sbjct: 31642 KVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRLLERPPEFTLPLYNKTA 31701
Query: 121 QIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKF 180
+G V+ + P +T W+K+G+ ++ + + D G L I +
Sbjct: 31702 YVGENVRFGVTITVHPEPHVT--WYKSGQKIKPGDNDKKYTFESD--KGLYQLTINSVTT 31757
Query: 181 TDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTV-PQEKSPLVT---REGDTIELQC 236
D YT VA K G S + ++ P + T+ P K L +EG ++ +
Sbjct: 31758 DDDAEYTVVARNKYGEDS-CKAKLTVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFEI 31816
Query: 237 QVTGKPKPIILWSRADKEVAM-PDGSMQMESYD-GTLRIVNVSREMSGMYRCQTSQYNG 293
+V+G P P + W + + +++ P+ + E D L I + E +G YR + G
Sbjct: 31817 RVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALHIRDTLPEDTGYYRVTATNTAG 31875
Score = 37.7 bits (86), Expect = 0.038
Identities = 37/140 (26%), Positives = 62/140 (44%), Gaps = 17/140 (12%)
Query: 68 IPAITSDDAGTYSCIANNNVG--NPAKKSTNIIVRALKKGRFWITPD--PYHKDDNIQIG 123
I +T + + +A N G +P + I+ + L I PD P ++Q+G
Sbjct: 23190 ITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLV-----IEPDVKPAFSSYSVQVG 23244
Query: 124 REVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDF 183
+++KI + P +T W K+G PL+ + R+ +T S T L I + D
Sbjct: 23245 QDLKIEVPISGRPKPTIT--WTKDGLPLKQTTRINVTD-----SLDLTTLSIKETHKDDG 23297
Query: 184 GTY-TCVASLKGGGISDISI 202
G Y VA++ G + I I
Sbjct: 23298 GQYGITVANVVGQKTASIEI 23317
Score = 37.4 bits (85), Expect = 0.050
Identities = 23/108 (21%), Positives = 48/108 (44%), Gaps = 7/108 (6%)
Query: 211 VPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDG-SMQMESYDG 269
+PP + +P++ + + G + ++ V GKP P W + + EV ++
Sbjct: 18898 LPPKILMPEQ---ITIKAGKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSSS 18954
Query: 270 TLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAF 317
L I +V+R+ SG Y +G + + + +++ P +P F
Sbjct: 18955 ILIIKDVTRKDSGYYSLTAENSSGTDT---QKIKVVVMDAPGPPQPPF 18999
Score = 37.4 bits (85), Expect = 0.050
Identities = 69/301 (22%), Positives = 116/301 (38%), Gaps = 51/301 (16%)
Query: 212 PPNLTV-PQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYD-- 268
PP +++ P+ K +V G++ ++ + GKP P I W + D+E++ ++++S D
Sbjct: 22540 PPRISMDPKYKDTIVVHAGESFKVDADIYGKPIPTIQWIKGDQELS-NTARLEIKSTDFA 22598
Query: 269 GTLRIVNVSREMSGMYRCQTSQYNG-----FNVK------PREALVQL---------IVQ 308
+L + + R SG Y + G NVK P E V + +
Sbjct: 22599 TSLSVKDAVRVDSGNYILKAKNVAGERSVTVNVKVLDRPGPPEGPVVISGVTAEKCTLAW 22658
Query: 309 YPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYA 368
PP + I +R T S V V T ++ KLL E EY
Sbjct: 22659 KPPLQDGGSDIINYIVERRET-SRLVWTVVDANVQTLSCKV-TKLL--------EGNEYT 22708
Query: 369 VKSLSNENYGVYNCSIINEAGAGRCSFLVTGKAYAPEFYYDTYNPVWQNRHRVYSYSLQW 428
+ ++ YGV + +E + F+V APE T + S + W
Sbjct: 22709 FRIMAVNKYGVGE-PLESEPVVAKNPFVVPDAPKAPEVTTVTKD----------SMIVVW 22757
Query: 429 TQMNPDAVDRIVAYRLGIRQAGQQRWWEQEIKINGNIQKGELITYNLTELIKPEAYEVRL 488
+ D I+ Y L R RW ++ G ++ +T LI+ YE R+
Sbjct: 22758 ERPASDGGSEILGYVLEKRDKEGIRWTRCHKRLIGELR------LRVTGLIENHDYEFRV 22811
Query: 489 T 489
+
Sbjct: 22812 S 22812
Score = 37.0 bits (84), Expect = 0.065
Identities = 71/326 (21%), Positives = 116/326 (35%), Gaps = 61/326 (18%)
Query: 221 KSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVN--VSR 278
K ++ + G+ L+ V+G+P P + WS+ KE+ ++++ D + +VN +R
Sbjct: 21468 KDTVILKAGEAFRLEADVSGRPPPTMEWSKDGKELE-GTAKLEIKIADFSTNLVNKDSTR 21526
Query: 279 EMSGMYRCQTSQYNG-----FNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCR 333
SG Y + G FNVK + PP A E VT
Sbjct: 21527 RDSGAYTLTATNPGGFAKHIFNVKVLDR------PGPPEGPLAVTE--------VTSEKC 21572
Query: 334 VLRAYP--------IRVLTYEWRLGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSII 385
VL +P I + R ++L T + T+ V L N ++ +
Sbjct: 21573 VLSWFPPLDDGGAKIDHYIVQKRETSRLAWTNVASEVQVTKLKVTKLLKGNEYIFRVMAV 21632
Query: 386 NEAGAGRCSFLVTGKAYAPEFYYDTYNPVWQNRHRVY------SYSLQWTQMNPDAVDRI 439
N+ G G P + Y P ++ S + W + D I
Sbjct: 21633 NKYGVGE------PLESEPVLAVNPYGPPDPPKNPEVTTITKDSMVVCWGHPDSDGGSEI 21686
Query: 440 VAYRLGIRQAGQQRWWEQEIKINGNIQKGELITYNLTELIKPEAYEVRL----------- 488
+ Y + R QRW IK N + Y ++ L + YE R+
Sbjct: 21687 INYIVERRDKAGQRW----IKCNKKTLTD--LRYKVSGLTEGHEYEFRIMAENAAGISAP 21740
Query: 489 TPLTKFGEGDSTIRVIKYSAPVNPHL 514
+P + F + T V K P NP +
Sbjct: 21741 SPTSPFYKACDT--VFKPGPPGNPRV 21764
Score = 37.0 bits (84), Expect = 0.065
Identities = 44/178 (24%), Positives = 70/178 (39%), Gaps = 20/178 (11%)
Query: 68 IPAITSDDAGTYSCIANNNVG--NPAKKSTNIIVRALKKGRFWITPDPYHKDDNI-QIGR 124
+ + D + IA N G + +ST I + I+ DP +KD + G
Sbjct: 22500 VTGLVEDHRYEFRVIARNAAGVFSEPSESTGAITARDEVDPPRISMDPKYKDTIVVHAGE 22559
Query: 125 EVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFG 184
K+ + P T W K + L ++ R+ I TD T+L + D D G
Sbjct: 22560 SFKVDADIYGKPIP--TIQWIKGDQELSNTARLEIKSTD-----FATSLSVKDAVRVDSG 22612
Query: 185 TYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKP 242
Y A G S ++++V + PP + P+V G T E +C + KP
Sbjct: 22613 NYILKAKNVAGERS-VTVNVKVLDRPGPP-------EGPVVI-SGVTAE-KCTLAWKP 22660
Score = 37.0 bits (84), Expect = 0.065
Identities = 68/347 (19%), Positives = 130/347 (37%), Gaps = 26/347 (7%)
Query: 160 TQTDPDVSPGTTNLDIIDL-KFTDFGTYTCVASLKG-GGISDISIDVNISSSTVPPNLTV 217
T P TN+++ L + ++ C + G G +D+ + + P++ +
Sbjct: 22885 TMCTPPTGINKTNIEVEKLLEKHEYNFRICAINKAGVGEHADVPGPIIVEEKLEAPDIDL 22944
Query: 218 PQEKSPLVT-REGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNV 276
E ++ R G ++ L + G+P P + W + D E+ + + S +L + NV
Sbjct: 22945 DLELRKIINIRAGGSLRLFVPIKGRPTPEVKWGKVDGEI-RDAAIIDVTSSFTSLVLDNV 23003
Query: 277 SREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVL- 335
+R SG Y +G K V+++ P V EI + S+T +L
Sbjct: 23004 NRYDSGKYTLTLENSSG--TKSAFVTVRVLDTPSPPVNLKVTEITK-DSVSITWEPPLLD 23060
Query: 336 RAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAG---- 391
I+ E R + + + + L + + NE G G
Sbjct: 23061 GGSKIKNYIVEKREATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRVTAENEYGIGLPAQ 23120
Query: 392 RCSFLVTGKAYAPEFYYDTYNPVWQNRHRVYSYSLQWTQMNPDAVDRIVAYRLGIRQAGQ 451
+ + P T + V +N S SL WT+ D +I+ Y + ++
Sbjct: 23121 TADPIKVAEVPQPPGKI-TVDDVTRN-----SVSLSWTKPEHDGGSKIIQYIVEMQAKHS 23174
Query: 452 QRWWEQEIKINGNIQKGELITYNLTELIKPEAYEVRLTPLTKFGEGD 498
++W E ++ + + NLT+ E Y R+ + + G D
Sbjct: 23175 EKWSE-----CARVKSLQAVITNLTQ---GEEYLFRVVAVNEKGRSD 23213
Score = 37.0 bits (84), Expect = 0.065
Identities = 85/408 (20%), Positives = 142/408 (34%), Gaps = 37/408 (9%)
Query: 213 PNLTVPQE-KSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTL 271
P L + E + +V R G + + G+P P I WSR + E + +Y L
Sbjct: 24022 PELDLDSELRKGIVVRAGGSARIHIPFKGRPTPEITWSREEGEFTDKVQIEKGVNYT-QL 24080
Query: 272 RIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMS 331
I N R +G Y + +G K V+++ P A E+R+ V
Sbjct: 24081 SIDNCDRNDAGKYILKLENSSGS--KSAFVTVKVLDTPGPPQNLAVKEVRKDSAFLVWEP 24138
Query: 332 CRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAG 391
+ ++ + R + T + V++L+ + NE G G
Sbjct: 24139 PIIDGGAKVKNYVIDKRESTRKAYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFGVG 24198
Query: 392 RCSFLVTG-KAYAPEFYYD--TYNPVWQNRHRVYSYSLQWTQMNPDAVDRIVAYRLGIRQ 448
V KA P T V Q S SL W + D R++ Y + ++
Sbjct: 24199 VPVETVDAVKAAEPPSPPGKVTLTDVSQT-----SASLMWEKPEHDGGSRVLGYVVEMQP 24253
Query: 449 AGQQRWWEQEIKINGNIQKGELITYNLTELIKPEAYEVRLTPLTKFGEGDST---IRVIK 505
G ++W + + ++ +T L + Y+ R+ + G+ D + VI
Sbjct: 24254 KGTEKW--------SIVAESKVCNAVVTGLSSGQEYQFRVKAYNEKGKSDPRVLGVPVIA 24305
Query: 506 YSAPVNPHLR------EFHCGFEDGNICL-FTQDDTDNFDWTK-----QSTATRNTKYTP 553
+ P L+ G ED I + N W K + T N + T
Sbjct: 24306 KDLTIQPSLKLPFNTYSIQAG-EDLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETA 24364
Query: 554 NTGPNADRSGSKEGFYMYIETSRPRLEGEKARLLSPVFSIAPKNPYGP 601
+ + G+K+ F Y T+ G LS + P P GP
Sbjct: 24365 TSTVLHIKEGNKDDFGKYTVTA-TNSAGTATENLSVIVLEKPGPPVGP 24411
Score = 36.6 bits (83), Expect = 0.085
Identities = 46/176 (26%), Positives = 65/176 (36%), Gaps = 21/176 (11%)
Query: 36 VTTGGEPAPSLTWVRSF-----GTLPEKTVLNGGT----LTIPAITSDDAGTYSCIANNN 86
VT P P +TW +S G +K LTI ++T+DD Y+ +A N
Sbjct: 31711 VTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNK 31770
Query: 87 VGNPAKKSTNIIVRALKKGRFWITPDPYHK----DDNIQIGREVKISCQVEAVPSEELTF 142
G + K+ + L T P K + Q G+ V +V +P T
Sbjct: 31771 YGEDSCKAK--LTVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFEIRVSGIPPP--TL 31826
Query: 143 SWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGIS 198
W K+G+PL + I D L I D D G Y A+ G S
Sbjct: 31827 KWEKDGQPLSLGPNIEIIHEGLDYYA----LHIRDTLPEDTGYYRVTATNTAGSTS 31878
Score = 36.2 bits (82), Expect = 0.11
Identities = 37/142 (26%), Positives = 60/142 (42%), Gaps = 25/142 (17%)
Query: 362 QEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVTGKAYAPEFYYDTYNPVWQNRHRV 421
QE TEY + + IN+AG G+ S + AYA + Y P + +V
Sbjct: 19553 QEGTEYE-----------FRVTAINKAGPGKPSD-ASKAAYARDPQYPPGPPAFP---KV 19597
Query: 422 Y-----SYSLQWTQMNPDAVDRIVAYRLGIRQAGQQRWWEQEIKINGNIQKGELITYNLT 476
Y S SL W + D I+ Y + +++A W + N+QK + +T
Sbjct: 19598 YDTTRSSVSLSWGKPAYDGGSPIIGYLVEVKRADSDNW--VRCNLPQNLQK---TRFEVT 19652
Query: 477 ELIKPEAYEVRLTPLTKFGEGD 498
L++ Y+ R+ + K G D
Sbjct: 19653 GLMEDTQYQFRVYAVNKIGYSD 19674
Score = 35.8 bits (81), Expect = 0.14
Identities = 34/139 (24%), Positives = 56/139 (40%), Gaps = 14/139 (10%)
Query: 122 IGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFT 181
+G C V PS +T +W K+G +R S + D L IID++ +
Sbjct: 11132 VGSSAIFECLVS--PSTAIT-TWMKDGSNIRESPKHRFIADGKD-----RKLHIIDVQLS 11183
Query: 182 DFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGK 241
D G YTCV L G + + + +P E+ V + G + L C++ +
Sbjct: 11184 DAGEYTCVLRL---GNKEKTSTAKLVVEELPVRFVKTLEEEVTVVK-GQPLYLSCELNKE 11239
Query: 242 PKPIILWSRADKEVAMPDG 260
++W + K V G
Sbjct: 11240 RD--VVWRKDGKIVVEKPG 11256
Score = 35.8 bits (81), Expect = 0.14
Identities = 29/117 (24%), Positives = 49/117 (41%), Gaps = 16/117 (13%)
Query: 13 PSIKLLVD-DPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLNGGT----LT 67
P I+L D +VV A + VT G P P + W ++ G L ++ + + L
Sbjct: 25105 PEIELDADLRKVVVLRASATLRLFVTIKGRPEPEVKWEKAEGILTDRAQIEVTSSFTMLV 25164
Query: 68 IPAITSDDAGTYSCIANNNVGNPA-----------KKSTNIIVRALKKGRFWITPDP 113
I +T D+G Y+ NN G+ N+ +R +KK ++ +P
Sbjct: 25165 IDNVTRFDSGRYNLTLENNSGSKTAFVNVRVLDSPSAPVNLTIREVKKDSVTLSWEP 25221
Score = 35.4 bits (80), Expect = 0.19
Identities = 102/482 (21%), Positives = 171/482 (35%), Gaps = 90/482 (18%)
Query: 23 IVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEK-----TVLNG-GTLTIPAITSDDA 76
+ V GE++TL C +G P+P++TW R + T +G L I ++D+
Sbjct: 952 VTVIEGESVTLECHISG-YPSPTVTWYREDYQIESSIDFQITFQSGIARLMIREAFAEDS 1010
Query: 77 GTYSCIANNNVGNPA-------------KKSTNIIVR--ALKKGRFWITPDPYHKDDNIQ 121
G ++C A N G + +K T + ++ RF + D D ++
Sbjct: 1011 GRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTTEEKRFVESRDVVMTDTSLT 1070
Query: 122 ------------------------IGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERM 157
G V CQV P + W K+G PL + R
Sbjct: 1071 EEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHV--YWKKSGVPLTTGYRY 1128
Query: 158 VITQTDPDVSPGTTNLDIIDLKFT-DFGTYTCVASLKGGGISDISIDVNISSSTVPPNLT 216
++ + G L +I + F D G YT V K G + S ++ L
Sbjct: 1129 KVSY---NKQTGECKL-VISMTFADDAGEYTIVVRNKHG---ETSASASLLEEADYELLM 1181
Query: 217 VPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEV---------AMPDGSMQMESY 267
Q++ T+ T +Q G+ P ++S +KE M ++ + +Y
Sbjct: 1182 KSQQEMLYQTQV--TAFVQEPKVGETAPGFVYSEYEKEYEKEQALIRKKMAKDTVVVRTY 1239
Query: 268 --DGTLRIVNVSREM--SGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAF----LE 319
D I + + YR + + E + + + AVE F
Sbjct: 1240 VEDQEFHISSFEERLIKEIEYRIIKTTLEELLEEDGEEKMAVDISESEAVESGFDSRIKN 1299
Query: 320 IRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAVKSLS-----N 374
R + VT C+ + YP+ + W K ++ G+ ++ + SL
Sbjct: 1300 YRILEGMGVTFHCK-MSGYPLPKIA--WYKDGKRIKHGERYQMDFLQDGRASLRIPVVLP 1356
Query: 375 ENYGVYNCSIINEAGAGRCSFLVTGKAY---APEFYYDTYNPVWQNRHRVYSYSLQWTQM 431
E+ G+Y N G CS GK Y A TY P + R+ S S +
Sbjct: 1357 EDEGIYTAFASNIKGNAICS----GKLYVEPAAPLGAPTYIPTLEPVSRIRSLSPRSVSR 1412
Query: 432 NP 433
+P
Sbjct: 1413 SP 1414
Score = 35.4 bits (80), Expect = 0.19
Identities = 44/221 (19%), Positives = 90/221 (40%), Gaps = 33/221 (14%)
Query: 66 LTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGRE 125
L I +++D+ Y+ + N+ + T I++ ++ K I E
Sbjct: 2938 LIIMNTSTEDSAEYTFVCGNDQVSATLTVTPIMITSMLK----------------DINAE 2981
Query: 126 VKISCQVEA-VPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFG 184
K + E V E +++ W KNG ++S+++ + T +L+I ++ F D
Sbjct: 2982 EKDTITFEVTVNYEGISYKWLKNGVEIKSTDKCQMR-----TKKLTHSLNIRNVHFGDAA 3036
Query: 185 TYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKP 244
YT VA K + + ++ ++ + + E +C+V+ +P
Sbjct: 3037 DYTFVAG-KATSTATLYVEAR--------HIEFRKHIKDIKVLEKKRAMFECEVS-EPDI 3086
Query: 245 IILWSRADKEVAMPDG-SMQMESYDGTLRIVNVSREMSGMY 284
+ W + D+E+ + D +Q E Y L I + +G Y
Sbjct: 3087 TVQWMKDDQELQITDRIKIQKEKYVHRLLIPSTRMSDAGKY 3127
Score = 35.4 bits (80), Expect = 0.19
Identities = 32/134 (23%), Positives = 56/134 (41%), Gaps = 30/134 (22%)
Query: 18 LVDD---PIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLNG----GTLTIPA 70
L DD + + G ++ L+ V+ G P P +TW + L + +++ L +
Sbjct: 29448 LADDLKKTVTIRAGASLRLM-VSVSGRPPPVITWSKQGIDLASRAIIDTTESYSLLIVDK 29506
Query: 71 ITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISC 130
+ DAG Y+ A N G KKS ++V+ + TP P S
Sbjct: 29507 VNRYDAGKYTIEAENQSG---KKSATVLVKV------YDTPGPCP-------------SV 29544
Query: 131 QVEAVPSEELTFSW 144
+V+ V + +T +W
Sbjct: 29545 KVKEVSRDSVTITW 29558
Score = 35.0 bits (79), Expect = 0.25
Identities = 25/103 (24%), Positives = 42/103 (40%), Gaps = 9/103 (8%)
Query: 200 ISIDVNISSSTVPPN--LTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAM 257
+ ++V I VPP L + + + G+ + + VTG P P I WS+ + +
Sbjct: 15382 LPLNVVIQDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLPMPKIEWSKNETVIEK 15441
Query: 258 PDGSMQMESYDGT-------LRIVNVSREMSGMYRCQTSQYNG 293
P ++Q+ + + L I RE G Y S G
Sbjct: 15442 PTDALQITKEEVSRSEAKTELSIPKAVREDKGTYTVTASNRLG 15484
Score = 35.0 bits (79), Expect = 0.25
Identities = 32/115 (27%), Positives = 46/115 (40%), Gaps = 27/115 (23%)
Query: 36 VTTGGEPAPSLTWVRSFGTLPEKTVLNG------GTLTIPAITSDDAGTYSCIANNNVGN 89
V G P P++TW + L + T +N TL+I DD G Y N VG
Sbjct: 23251 VPISGRPKPTITWTKDGLPLKQTTRINVTDSLDLTTLSIKETHKDDGGQYGITVANVVG- 23309
Query: 90 PAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSW 144
+K+ +I + L K PDP K + + V +E +T SW
Sbjct: 23310 --QKTASIEIVTLDK------PDP------------PKGPVKFDDVSAESITLSW 23344
Score = 35.0 bits (79), Expect = 0.25
Identities = 35/154 (22%), Positives = 62/154 (40%), Gaps = 19/154 (12%)
Query: 361 SQEYTEYAVKSLSNENYGVYNCSIINEAG--AGRCSFLVTGKAYAPEFYYDTYNPVWQNR 418
S+ +TE +K + G Y+ + N+ G A V G +PE P+ +
Sbjct: 30186 SETHTELVIKEADRGDSGTYDLVLENKCGKKAVYIKVRVIGSPNSPE------GPLEYDD 30239
Query: 419 HRVYSYSLQWTQMNPDAVDRIVAYRLGIRQAGQQRWWEQEIKINGNIQKGELITYNLTEL 478
+V S + W D I+ Y L R+ + W+ + ++ G L+ L E
Sbjct: 30240 IQVRSVRVSWRPPADDGGADILGYILERREVPKAAWYTIDSRVRGT----SLVVKGLKEN 30295
Query: 479 IKPEAYEVRLTPLTKFGEGDSTIRVIKYSAPVNP 512
++ Y R++ +FG + +K PV P
Sbjct: 30296 VE---YHFRVSAENQFG----ISKPLKSEEPVTP 30322
Score = 35.0 bits (79), Expect = 0.25
Identities = 63/317 (19%), Positives = 120/317 (37%), Gaps = 59/317 (18%)
Query: 92 KKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPL 151
+KST ++ R P + + G + SC + P +T W + G+ L
Sbjct: 32548 EKSTTRKIKTTLAARILTKP----RSMTVYEGESARFSCDTDGEPVPTVT--WLRKGQVL 32601
Query: 152 RSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVA-SLKGGGISDISIDVNISSST 210
+S R +T T + +I ++ +D G Y+ V + +G ++ ++ + + T
Sbjct: 32602 STSARHQVTTTKYK-----STFEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQKARVT 32656
Query: 211 VPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGT 270
+ P+ KSP + P+ + ++ K V P+ S
Sbjct: 32657 EKAVTSPPRVKSPEPRVKS------------PEAV----KSPKRVKSPEPS--------- 32691
Query: 271 LRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTM 330
+ +T P E + L V PP + FL+ ++ + +
Sbjct: 32692 --------HPKAVSPTETKP------TPTEKVQHLPVSAPPKITQ-FLKAEASKEIA-KL 32735
Query: 331 SCRVLRAYPIRVLTYEW-RLGNKLLRTGQFD---SQEYT-EYAVKSLSNENYGVYNCSII 385
+C V+ + +R W + G KL G F S + T E + +L+ + G Y C I
Sbjct: 32736 TC-VVESSVLRAKEVTWYKDGKKLKENGHFQFHYSADGTYELKINNLTESDQGEYVCEIS 32794
Query: 386 NEAGAGRCSFLVTGKAY 402
E G + + G+A+
Sbjct: 32795 GEGGTSKTNLQFMGQAF 32811
Score = 34.7 bits (78), Expect = 0.32
Identities = 24/125 (19%), Positives = 55/125 (44%), Gaps = 8/125 (6%)
Query: 195 GGISDISIDVNISSSTVPPNLTVPQE-KSPLVTREGDTIELQCQVTGKPKPIILWSRADK 253
G ++D+ + + V P+L + + +V G I + V+GKP P + W+ ++
Sbjct: 16507 GEVTDV---IEMKDRLVSPDLQLDASVRDRIVVHAGGVIRIIAYVSGKPPPTVTWNMNER 16563
Query: 254 EVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAV 313
+ + +++ + ++ I N R G+Y G + ++ ++ ++ P V
Sbjct: 16564 TLPQ-EATIETTAISSSMVIKNCQRSHQGVYSLLAKNEAG---ERKKTIIVDVLDVPGPV 16619
Query: 314 EPAFL 318
FL
Sbjct: 16620 GTPFL 16624
Score = 34.3 bits (77), Expect = 0.42
Identities = 54/243 (22%), Positives = 95/243 (39%), Gaps = 36/243 (14%)
Query: 229 GDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQT 288
GDT+ L + G P P + W + D++ A + + L I N + E G+Y
Sbjct: 17233 GDTLRLSAIIKGVPFPKVTWKKEDRD-APTKARIDVTPVGSKLEIRNAAHEDGGIYSLTV 17291
Query: 289 SQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCR--------VLRAYPI 340
G + V+++V P P LE+ + + S ++ + V+ Y +
Sbjct: 17292 ENPAG----SKTVSVKVLVLDKPG-PPRDLEVSEIRKDSCYLTWKEPLDDGGSVITNYVV 17346
Query: 341 R---VLTYEWRLGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLV 397
V + +W + L T + S + K L+ N ++ + N+ G G F+
Sbjct: 17347 ERRDVASAQW---SPLSATSKKKS-----HFAKHLNEGNQYLFRVAAENQYGRG--PFVE 17396
Query: 398 TGKAYAPEFYYDTYNPVW--QNRHRV----YSYSLQWTQMNPDAVDRIVAYRLGIRQAGQ 451
T K P D +P ++ H V SL W + + D I Y + ++ G
Sbjct: 17397 TPK---PIKALDPLHPPGPPKDLHHVDVDKTEVSLVWNKPDRDGGSPITGYLVEYQEEGT 17453
Query: 452 QRW 454
Q W
Sbjct: 17454 QDW 17456
Score = 34.3 bits (77), Expect = 0.42
Identities = 16/44 (36%), Positives = 28/44 (63%), Gaps = 1/44 (2%)
Query: 213 PNLTVPQEKSPLVT-REGDTIELQCQVTGKPKPIILWSRADKEV 255
P + +P E + +V R G +++L+ ++GKP P I W + DKE+
Sbjct: 26870 PVIDLPLEYTEVVKYRAGTSVKLRAGISGKPAPTIEWYKDDKEL 26913
Score = 33.9 bits (76), Expect = 0.55
Identities = 32/120 (26%), Positives = 51/120 (42%), Gaps = 36/120 (30%)
Query: 40 GEPAPSLTWVRS------------FGTLPEKTVLNGG-TLTIPAITSDDAGTYSCIANNN 86
G P P+LTW ++ + T K V++ TL IP D G Y+ A NN
Sbjct: 16142 GVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDTCTLVIPQSRRSDTGLYTITAVNN 16201
Query: 87 VGNPAKK-STNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWF 145
+G +K+ N++ R P P +G + E+V ++++T SWF
Sbjct: 16202 LGTASKEMRLNVLGR----------PGP-------PVG-----PIKFESVSADQMTLSWF 16239
Score = 33.9 bits (76), Expect = 0.55
Identities = 23/85 (27%), Positives = 36/85 (42%), Gaps = 8/85 (9%)
Query: 12 SPSIKL--LVDDPIVVNPGEAITLVCVTTGGEPAPSLTW------VRSFGTLPEKTVLNG 63
+P+I L + D + + G+ I L ++ G+P P +W +R +
Sbjct: 20375 APTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLPKSSWSKAGKDIRPSDITQITSTPTS 20434
Query: 64 GTLTIPAITSDDAGTYSCIANNNVG 88
LTI T DAG Y+ A N G
Sbjct: 20435 SMLTIKYATRKDAGEYTITATNPFG 20459
Score = 33.9 bits (76), Expect = 0.55
Identities = 41/210 (19%), Positives = 84/210 (40%), Gaps = 16/210 (7%)
Query: 113 PYHKDD----NIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSP 168
P+ K++ N++ + C+V P + W++ G+ + + Q +
Sbjct: 30928 PHFKEELRNLNVRYQSNATLVCKVTGHPKPIV--KWYRQGKEIIADGLKYRIQ---EFKG 30982
Query: 169 GTTNLDIIDLKFTDFGTYTCVASLKGGGISDI-SIDVNISSSTVPPNLTVPQEKSPLVTR 227
G L I + D Y A+ +GG +S S++V + + P + +
Sbjct: 30983 GYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTL--EGMGAVHAL 31040
Query: 228 EGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQM---ESYDGTLRIVNVSREMSGMY 284
G+ + ++ +GKP P+I W + +++ +G Q+ S+ + V R+ +G Y
Sbjct: 31041 RGEVVSIKIPFSGKPDPVITWQKG-QDLIDNNGHYQVIVTRSFTSLVFPNGVERKDAGFY 31099
Query: 285 RCQTSQYNGFNVKPREALVQLIVQYPPAVE 314
G + K E V + P V+
Sbjct: 31100 VVCAKNRFGIDQKTVELDVADVPDPPRGVK 31129
Score = 33.5 bits (75), Expect = 0.72
Identities = 70/348 (20%), Positives = 131/348 (37%), Gaps = 27/348 (7%)
Query: 13 PSIKLLVDDPIVVN--PGEAITLVCVTTGGEPAPSLTWVRSFGTLPE----KTVLNGGT- 65
P+ + P+V G ++ C GG P P + W +S L K N T
Sbjct: 1079 PAAPYFITKPVVQKLVEGGSVVFGC-QVGGNPKPHVYWKKSGVPLTTGYRYKVSYNKQTG 1137
Query: 66 ---LTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQI 122
L I +DDAG Y+ + N G + S +++ A + + ++
Sbjct: 1138 ECKLVISMTFADDAGEYTIVVRNKHGETSA-SASLLEEADYELLMKSQQEMLYQTQVTAF 1196
Query: 123 GREVKISCQVEAVPSEELTFSWFKNGRPLR---SSERMVITQTDPDVSPGTTNLD---II 176
+E K+ E + K +R + + +V+ D ++ + I
Sbjct: 1197 VQEPKVGETAPGFVYSEYEKEYEKEQALIRKKMAKDTVVVRTYVEDQEFHISSFEERLIK 1256
Query: 177 DLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQC 236
++++ T T L+ G +++D++ S V + ++ EG + C
Sbjct: 1257 EIEYRIIKT-TLEELLEEDGEEKMAVDIS-ESEAVESGFDSRIKNYRIL--EGMGVTFHC 1312
Query: 237 QVTGKPKPIILWSRADKEVAMPDGSMQMESYDG--TLRIVNVSREMSGMYRCQTSQYNGF 294
+++G P P I W + K + + DG +LRI V E G+Y S G
Sbjct: 1313 KMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDGRASLRIPVVLPEDEGIYTAFASNIKGN 1372
Query: 295 NVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRV 342
+ + V+ P P ++ + R ++S R + PIR+
Sbjct: 1373 AICSGKLYVE---PAAPLGAPTYIPTLEPVSRIRSLSPRSVSRSPIRM 1417
Score = 33.5 bits (75), Expect = 0.72
Identities = 27/96 (28%), Positives = 45/96 (46%), Gaps = 9/96 (9%)
Query: 10 TASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLN------G 63
T PS+KL + + GE + + + G P P+++WV+ L + T +N
Sbjct: 24309 TIQPSLKLPFNT-YSIQAGEDLKIE-IPVIGRPRPNISWVKDGEPLKQTTRVNVEETATS 24366
Query: 64 GTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIV 99
L I DD G Y+ A N+ G A ++ ++IV
Sbjct: 24367 TVLHIKEGNKDDFGKYTVTATNSAGT-ATENLSVIV 24401
Score = 33.5 bits (75), Expect = 0.72
Identities = 34/168 (20%), Positives = 62/168 (36%), Gaps = 24/168 (14%)
Query: 6 LSNKTASPSIKLLVDDPIVVN-------PGEAITLVCVTTGGEPAPSLTWVRSFGTLPEK 58
++ KT + + + P++V +++ V GEP P+ W + K
Sbjct: 32836 VTRKTEPKAPEPISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKD-----GK 32890
Query: 59 TVLNGGT-----------LTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRF 107
+ GG L I + D+G Y+C N+ G+ S + ++A+K
Sbjct: 32891 AITQGGKYKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGS-VSSSCKLTIKAIKDTEA 32949
Query: 108 WITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSE 155
+ Q V+ +A+ SEE+ S K+ L E
Sbjct: 32950 QKVSTQKTSEITPQKKAVVQEEISQKALRSEEIKMSEAKSQEKLALKE 32997
Score = 33.1 bits (74), Expect = 0.94
Identities = 32/140 (22%), Positives = 57/140 (40%), Gaps = 18/140 (12%)
Query: 116 KDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDI 175
+D ++ G+ ++CQ +VP+ + WF+NGR L+ R +V L I
Sbjct: 8752 QDVTLKEGQTCTMTCQF-SVPN--VKSEWFRNGRILKPQGR-----HKTEVEHKVHKLTI 8803
Query: 176 IDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQ 235
D++ D G YTC D+ + P T + +V E + +
Sbjct: 8804 ADVRAEDQGQYTC-------KYEDLETSAELRIEAEPIQFT--KRIQNIVVSEHQSATFE 8854
Query: 236 CQVTGKPKPIILWSRADKEV 255
C+V+ I+ W + E+
Sbjct: 8855 CEVS-FDDAIVTWYKGPTEL 8873
Score = 33.1 bits (74), Expect = 0.94
Identities = 10/30 (33%), Positives = 20/30 (66%)
Query: 224 LVTREGDTIELQCQVTGKPKPIILWSRADK 253
++ + GD I+++ V G+PKP + W + D+
Sbjct: 21075 VIAKAGDNIKVEIPVLGRPKPTVTWKKGDQ 21104
Score = 32.7 bits (73), Expect = 1.2
Identities = 21/67 (31%), Positives = 30/67 (44%), Gaps = 7/67 (10%)
Query: 40 GEPAPSLTWVRSFGTLPEKTVLNGGT----LTIPAITSDDAGTYSCIANNNVGNPAKKST 95
G P P +TW R G +K + G L+I +DAG Y N+ G+ KS
Sbjct: 24050 GRPTPEITWSREEGEFTDKVQIEKGVNYTQLSIDNCDRNDAGKYILKLENSSGS---KSA 24106
Query: 96 NIIVRAL 102
+ V+ L
Sbjct: 24107 FVTVKVL 24113
Score = 32.7 bits (73), Expect = 1.2
Identities = 25/83 (30%), Positives = 36/83 (43%), Gaps = 8/83 (9%)
Query: 24 VVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEK----TVLNGGTLTIPAITSDDAGTY 79
VV G +I L + G P P+ W + L + T + TLT+ +DAG Y
Sbjct: 28368 VVRAGASIRLF-IAYQGRPTPTAVWSKPDSNLSLRADIHTTDSFSTLTVENCNRNDAGKY 28426
Query: 80 SCIANNNVGNPAKKSTNIIVRAL 102
+ NN G+ KS V+ L
Sbjct: 28427 TLTVENNSGS---KSITFTVKVL 28446
Score = 32.3 bits (72), Expect = 1.6
Identities = 47/203 (23%), Positives = 86/203 (42%), Gaps = 38/203 (18%)
Query: 66 LTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGRE 125
LT+ +T +D G YS + + K + L+ ++ + D +Q+ E
Sbjct: 2323 LTVKDVTKEDQGEYSFVIDGKKTTCKLKMKPRPIAILQ----GLSDQKVCEGDIVQL--E 2376
Query: 126 VKISCQ-VEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFG 184
VK+S + VE V W K+G+ ++ S+R+ I + + L I D+ D G
Sbjct: 2377 VKVSLESVEGV--------WMKDGQEVQPSDRVHIV-----IDKQSHMLLIEDMTKEDAG 2423
Query: 185 TYTCVASLKG----GGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTG 240
Y+ G G +S S+DV +T ++ + + EG L+C+V+
Sbjct: 2424 NYSFTIPALGLSTSGRVSVYSVDV----------ITPLKDVNVI---EGTKAVLECKVSV 2470
Query: 241 KPKPIILWSRADKEVAMPDGSMQ 263
+ W D+++ PD +Q
Sbjct: 2471 PDVTSVKWYLNDEQI-KPDDRVQ 2492
Score = 32.3 bits (72), Expect = 1.6
Identities = 26/92 (28%), Positives = 41/92 (44%), Gaps = 16/92 (17%)
Query: 13 PSIKLLVD---DPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLNGGT---- 65
P+IKL + D I V GE + + TG P P + W ++ + + T T
Sbjct: 15395 PTIKLRLSVRGDTIKVKAGEPVHIPADVTG-LPMPKIEWSKNETVIEKPTDALQITKEEV 15453
Query: 66 --------LTIPAITSDDAGTYSCIANNNVGN 89
L+IP +D GTY+ A+N +G+
Sbjct: 15454 SRSEAKTELSIPKAVREDKGTYTVTASNRLGS 15485
Score = 32.3 bits (72), Expect = 1.6
Identities = 21/83 (25%), Positives = 37/83 (44%), Gaps = 4/83 (4%)
Query: 204 VNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQ 263
+ PP L + + L R G+ L + +GKPKP + W + + +V + D
Sbjct: 16809 ITCKDELAPPTLHL-DFRDKLTIRVGEAFALTGRYSGKPKPKVSWFKDEADV-LEDDRTH 16866
Query: 264 MESYDGTLRI--VNVSREMSGMY 284
+++ TL + + R SG Y
Sbjct: 16867 IKTTPATLALEKIKAKRSDSGKY 16889
Score = 32.0 bits (71), Expect = 2.1
Identities = 21/74 (28%), Positives = 32/74 (43%), Gaps = 1/74 (1%)
Query: 212 PPNLTVPQEKSPLV-TREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGT 270
PP + + LV R G I L V G+P P + W + + + G + +
Sbjct: 18603 PPEIDLDASMRKLVIVRAGCPIRLFAIVRGRPAPKVTWRKVGIDNVVRKGQVDLVDTMAF 18662
Query: 271 LRIVNVSREMSGMY 284
L I N +R+ SG Y
Sbjct: 18663 LVIPNSTRDDSGKY 18676
Score = 32.0 bits (71), Expect = 2.1
Identities = 54/263 (20%), Positives = 101/263 (38%), Gaps = 14/263 (5%)
Query: 221 KSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGT--LRIVNVSR 278
++ ++ + G+ +++ G+P P + W + +K + D +E+ D + L I V+R
Sbjct: 27278 RTSVIAKAGEDVQVLIPFKGRPPPTVTWRKDEKNLG-SDARYSIENTDSSSLLTIPQVTR 27336
Query: 279 EMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTM---SCRVL 335
+G Y G +P+ + V + V PA L+++ +VT+ +
Sbjct: 27337 NDTGKYILTIENGVG---EPKSSTVSVKVLDTPAACQK-LQVKHVSRGTVTLLWDPPLID 27392
Query: 336 RAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGR-CS 394
PI E R K + T + + LS + + NE G G C
Sbjct: 27393 GGSPIINYVIEKRDATKRTWSVVSHKCSSTSFKLIDLSEKTPFFFRVLAENEIGIGEPCE 27452
Query: 395 FLVTGKAYAPEFYYDTYNPVWQNRHRVYSYSLQWTQMNPDAVDRIVAYRLGIRQAGQQRW 454
T A E + ++ + S L WT+ + D I Y + + G+Q W
Sbjct: 27453 --TTEPVKAAEVPAPIRDLSMKDSTKT-SVILSWTKPDFDGGSVITEYVVERKGKGEQTW 27509
Query: 455 WEQEIKINGNIQKGELITYNLTE 477
I I+ +L ++ E
Sbjct: 27510 SHAGISKTCEIEVSQLKEQSVLE 27532
Score = 31.6 bits (70), Expect = 2.7
Identities = 31/156 (19%), Positives = 55/156 (35%), Gaps = 42/156 (26%)
Query: 130 CQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCV 189
C++ + + W +G+PL ++ R+ + G +LD D G TC
Sbjct: 1724 CRLTPIGDPTMVVEWLHDGKPLEAANRLRMINEF-----GYCSLDYGVAYSRDSGIITCR 1778
Query: 190 ASLKGG---------------------------GISDISIDVNISSSTVPPNLTVPQEKS 222
A+ K G G+ I ++ +T Q++
Sbjct: 1779 ATNKYGTDHTSATLIVKDEKSLVEESQLPEGRKGLQRIEELERMAHEGALTGVTTDQKEK 1838
Query: 223 ----------PLVTREGDTIELQCQVTGKPKPIILW 248
P+ EG+T +C+VTG P+P + W
Sbjct: 1839 QKPDIVLYPEPVRVLEGETARFRCRVTGYPQPKVNW 1874
Score = 31.6 bits (70), Expect = 2.7
Identities = 28/103 (27%), Positives = 43/103 (41%), Gaps = 8/103 (7%)
Query: 5 RLSNKTASPSIKLLVDDPIVVNPGEAITL-VCVTTGGEPAPSLTWVRSFGTLPEKTVLNG 63
+ ++ P I+L D VV TL + V G PAP + W R G +K +
Sbjct: 21850 KAEDRMLPPEIELDADLRKVVTIRACCTLRLFVPIKGRPAPEVKWARDHGESLDKASIES 21909
Query: 64 GT----LTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRAL 102
+ L + + D+G Y N+ G+ KS + VR L
Sbjct: 21910 TSSYTLLIVGNVNRFDSGKYILTVENSSGS---KSAFVNVRVL 21949
Score = 31.2 bits (69), Expect = 3.6
Identities = 14/31 (45%), Positives = 20/31 (64%), Gaps = 1/31 (3%)
Query: 224 LVTREGDTIELQCQVTGKPKPIILWSRADKE 254
L + GDTI L+ V GKP P + W++ DK+
Sbjct: 18211 LTVKAGDTIRLEAGVRGKPFPEVAWTK-DKD 18240
Score = 30.8 bits (68), Expect = 4.6
Identities = 48/207 (23%), Positives = 77/207 (37%), Gaps = 25/207 (12%)
Query: 65 TLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGR 124
TL I DD Y+ N+ G K + N+IV ++ + P KD +
Sbjct: 12695 TLRIRDAHLDDQANYNVSLTNHRGENVKSAANLIVE--EEDLRIVEP---LKDIETMEKK 12749
Query: 125 EVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFG 184
V C+V + +T W KNG + R+ V L I D F D G
Sbjct: 12750 SVTFWCKVNRL---NVTLKWTKNGEEVPFDNRVSYR-----VDKYKHMLTIKDCGFPDEG 12801
Query: 185 TYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKP 244
Y A + ++++ I P V + VT D + CQ++ + K
Sbjct: 12802 EYIVTAG-QDKSVAELLI-------IEAPTEFVEHLEDQTVTEFDDAV-FSCQLS-REKA 12851
Query: 245 IILWSRADKEVAMPDGSMQMESYDGTL 271
+ W R +E+ +G DG++
Sbjct: 12852 NVKWYRNGREI--KEGKKYKFEKDGSI 12876
Score = 30.8 bits (68), Expect = 4.6
Identities = 18/59 (30%), Positives = 26/59 (44%), Gaps = 8/59 (13%)
Query: 208 SSTVPPNLTVPQEKSPLV-------TREGDTIELQCQVTGKPKPIILWSRADKEVAMPD 259
S PP V +P V + GD I L ++G P P I W + D+ V +P+
Sbjct: 14666 SRATPPTKAVDPIDAPKVILRTSLEVKRGDEIALDASISGSPYPTITWIK-DENVIVPE 14723
Score = 30.8 bits (68), Expect = 4.6
Identities = 29/93 (31%), Positives = 42/93 (45%), Gaps = 9/93 (9%)
Query: 13 PSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVL------NGGTL 66
P+ KLL + V GE + V V G P P++TW + L + T + N L
Sbjct: 22148 PAFKLLFNT-FTVLAGEDLK-VDVPFIGRPTPAVTWHKDNVPLKQTTRVNAESTENNSLL 22205
Query: 67 TIPAITSDDAGTYSCIANNNVGNPAKKSTNIIV 99
TI +D G Y N+ G A ++ N+IV
Sbjct: 22206 TIKDACREDVGHYVVKLTNSAGE-AIETLNVIV 22237
Score = 30.8 bits (68), Expect = 4.6
Identities = 18/66 (27%), Positives = 31/66 (46%), Gaps = 6/66 (9%)
Query: 40 GEPAPSLTWVRSFGTLPEKTVLNGGT------LTIPAITSDDAGTYSCIANNNVGNPAKK 93
G P ++ W + TL E T +N + L+I + +D GTY +N+ G+
Sbjct: 25420 GRPQATVNWRKDGQTLKETTRVNVSSSKTVTSLSIKEASKEDVGTYELCVSNSAGSITVP 25479
Query: 94 STNIIV 99
T I++
Sbjct: 25480 ITIIVL 25485
Score = 30.4 bits (67), Expect = 6.1
Identities = 22/98 (22%), Positives = 42/98 (42%), Gaps = 2/98 (2%)
Query: 189 VASLKGGGISDIS-IDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIIL 247
V ++ G+S+ S I N+ + T+ E ++ EG+ + + P P +
Sbjct: 14360 VRAVNAIGVSEPSEISENVVAKDPDCKPTIDLETHDIIVIEGEKLSIPVPFRAVPVPTVS 14419
Query: 248 WSRADKEVAMPDG-SMQMESYDGTLRIVNVSREMSGMY 284
W + KEV D +M+ + L + R +G+Y
Sbjct: 14420 WHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIY 14457
Score = 30.4 bits (67), Expect = 6.1
Identities = 29/121 (23%), Positives = 54/121 (44%), Gaps = 20/121 (16%)
Query: 123 GREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTD 182
G ++ I AVP T SW K+G+ +++S+R +T + +S +L++ D
Sbjct: 14401 GEKLSIPVPFRAVPVP--TVSWHKDGKEVKASDR--LTMKNDHIS---AHLEVPKSVRAD 14453
Query: 183 FGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLV-TREGDTIELQCQVTGK 241
G YT I+++ + S+T N+ V P + D + C++T +
Sbjct: 14454 AGIYT------------ITLENKLGSATASINVKVIGLPGPCKDIKASDITKSSCKLTWE 14501
Query: 242 P 242
P
Sbjct: 14502 P 14502
Score = 30.4 bits (67), Expect = 6.1
Identities = 34/171 (19%), Positives = 71/171 (41%), Gaps = 19/171 (11%)
Query: 334 VLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAV-KSLSNENYGVYNCSIINEAGAGR 392
++R P +T+ + ++R GQ D + + V + + ++ G Y+ +++N AG
Sbjct: 18629 IVRGRPAPKVTWRKVGIDNVVRKGQVDLVDTMAFLVIPNSTRDDSGKYSLTLVNPAGEKA 18688
Query: 393 CSFLVTGKAYAPEFYYDTYNPVWQNRHRVY---SYSLQWTQMNPDAVDRIVAYRLGIRQA 449
V DT PV + S + W D ++ Y + R+A
Sbjct: 18689 VFVNVR--------VLDTPGPVSDLKVSDVTKTSCHVSWAPPENDGGSQVTHYIVEKREA 18740
Query: 450 GQQRWWEQEIKINGNIQKGELITYNLTELIKPEAYEVRLTPLTKFGEGDST 500
++ W + ++K ++++T L+ Y R+T + ++G G T
Sbjct: 18741 DRKTW----STVTPEVKK---TSFHVTNLVPGNEYYFRVTAVNEYGPGVPT 18784
Score = 30.4 bits (67), Expect = 6.1
Identities = 19/70 (27%), Positives = 34/70 (48%), Gaps = 7/70 (10%)
Query: 120 IQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLK 179
++IG V + + P + SW K+G PL+ SE + ++T+ ++ L I + K
Sbjct: 27575 VRIGHNVHLELPYKGKPKPSI--SWLKDGLPLKESEFVRFSKTENKIT-----LSIKNAK 27627
Query: 180 FTDFGTYTCV 189
G YT +
Sbjct: 27628 KEHGGKYTVI 27637
Score = 30.0 bits (66), Expect = 7.9
Identities = 15/65 (23%), Positives = 34/65 (52%), Gaps = 3/65 (4%)
Query: 189 VASLKGGGISDISI--DVNISSSTVPPNLTVPQE-KSPLVTREGDTIELQCQVTGKPKPI 245
++++ G+ + ++ DV I + P+ + E + LV R G +I + + G+P P
Sbjct: 20748 ISAINDAGVGEPAVIPDVEIVEREMAPDFELDAELRRTLVVRAGLSIRIFVPIKGRPAPE 20807
Query: 246 ILWSR 250
+ W++
Sbjct: 20808 VTWTK 20812
Score = 30.0 bits (66), Expect = 7.9
Identities = 10/51 (19%), Positives = 27/51 (52%), Gaps = 1/51 (1%)
Query: 206 ISSSTVPPNLTVPQE-KSPLVTREGDTIELQCQVTGKPKPIILWSRADKEV 255
+ PP + + + + +V + G+ +++ + G+P P+I W++ E+
Sbjct: 25780 VKDDVEPPRVMMDVKFRDVIVVKAGEVLKINADIAGRPLPVISWAKDGIEI 25830
Score = 30.0 bits (66), Expect = 7.9
Identities = 29/111 (26%), Positives = 48/111 (43%), Gaps = 12/111 (10%)
Query: 23 IVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLNGGT----LTIPAITSDDAGT 78
I V G I L + G+P P W + + ++ ++ L I D+GT
Sbjct: 30146 IFVRQGGVIRLT-IPIKGKPFPICKWTKEGQDISKRAMIATSETHTELVIKEADRGDSGT 30204
Query: 79 YSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKIS 129
Y + N G KK+ I VR + +P+ + D+IQ+ R V++S
Sbjct: 30205 YDLVLENKCG---KKAVYIKVRVIGSPN---SPEGPLEYDDIQV-RSVRVS 30248
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 95.1 bits (235), Expect = 2e-19
Identities = 95/384 (24%), Positives = 169/384 (44%), Gaps = 46/384 (11%)
Query: 28 GEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTV----LNGGTLTIPAITSDDAGTYSCIA 83
G + L C G PAP++TW++ + V GG L + + AGTY+C+A
Sbjct: 1948 GSPLVLTC-DVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVA 2006
Query: 84 NNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFS 143
N A+ + +V L R I ++ ++ G+EV++ C+ + P ++ +
Sbjct: 2007 EN---TQAEARKDFVVAVLVAPR--IRSSGVAREHHVLEGQEVRLDCEADGQPPPDV--A 2059
Query: 144 WFKNGRPLRSSERMVITQTDPDVSPGTT------NLDIIDLKFTDFGTYTCVASLKGGGI 197
W K+G PL D+ P +L + L+ +D G YTCVA G
Sbjct: 2060 WLKDGSPL-----------GQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGED 2108
Query: 198 SDISIDVNISSSTVPPNLTVPQEKS-PLVTREGDTIELQCQVTGKPKPIILWSRADKEVA 256
+ + VN+ VPP + + S LV+R G+ + + C V G P + W + +
Sbjct: 2109 ARLH-TVNV---LVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLP 2164
Query: 257 MPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPA 316
+ ++ + TLRI V +G++ C + G V R +Q VQ PP +EP
Sbjct: 2165 LSQRTL-LHGSGHTLRISKVQLADAGIFTCVAASPAG--VADRNFTLQ--VQVPPVLEPV 2219
Query: 317 FL--EIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAVKSLSN 374
++ + V + C R P+ ++++ + G LL ++ ++++
Sbjct: 2220 EFQNDVVVVRGSLVELPCEA-RGVPLPLVSW-MKDGEPLLSQ---SLEQGPSLQLEAVGA 2274
Query: 375 ENYGVYNCSIINEAGAGRCSFLVT 398
+ G Y+C ++EAG R F +T
Sbjct: 2275 GDSGTYSCVAVSEAGEARRHFQLT 2298
Score = 94.0 bits (232), Expect = 4e-19
Identities = 94/319 (29%), Positives = 135/319 (42%), Gaps = 55/319 (17%)
Query: 23 IVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVL----NGGTLTIPAITSDDAGT 78
+ V + L+C G P P++TW + LP T + G L + S DAG
Sbjct: 321 VAVMEDHLVQLLCEARG-VPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGV 379
Query: 79 YSCIANNNVGNPAKKSTNIIVRALKK-----GRFWITPDPYHKDDNIQIGREVKISCQVE 133
Y+C A+N VG A+K+T + V GR ++ GR V + C
Sbjct: 380 YTCKASNAVG-AAEKATRLDVYVPPTIEGAGGRPYVV--------KAVAGRPVALECVAR 430
Query: 134 AVPSEELTFSWFKNGRPLRSSERMVITQTDPDV----SPGTTNLDIIDLKFTDFGTYTCV 189
PS T SW G P+ S + +TD V SPG + G Y+CV
Sbjct: 431 GHPSP--TLSWHHEGLPVAESNESRL-ETDGSVLRLESPGEASS----------GLYSCV 477
Query: 190 ASLKGG-GISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILW 248
AS G + S++V VPP L V + + T G +EL CQ +G P P I W
Sbjct: 478 ASSPAGEAVLQYSVEVQ-----VPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQW 532
Query: 249 ---SRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQL 305
R +E+A +Q+ S TL I +V + SG++ CQ + N E V +
Sbjct: 533 LQNGRPAEELA----GVQVASQGTTLHIDHVELDHSGLFACQAT--NEAGTAGAEVEVSV 586
Query: 306 IVQYPPAVEPAFLEIRQGQ 324
++ P V LE+ GQ
Sbjct: 587 HGEWAPGV----LEVPIGQ 601
Score = 93.6 bits (231), Expect = 6e-19
Identities = 103/389 (26%), Positives = 162/389 (41%), Gaps = 57/389 (14%)
Query: 28 GEAITLVCVTTGGEPAPSLTWVRSFGTLPE------KTVLNGGTLTIPAITSDDAGTYSC 81
G+ + L C G+P P + W++ L + + L+GG+L + + + DAG Y+C
Sbjct: 2041 GQEVRLDC-EADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTC 2099
Query: 82 IANNNVGNPAKKST-NIIVRALKK----GRFWITPDPYHKDDNIQIGREVKISCQVEAVP 136
+A+N G A+ T N++V K G + P G V + C V P
Sbjct: 2100 VAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRP---------GELVTMVCPVRGSP 2150
Query: 137 SEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGG 196
+ SW K+G PL S+R ++ G T L I ++ D G +TCVA+ G
Sbjct: 2151 --PIHVSWLKDGLPLPLSQRTLLH------GSGHT-LRISKVQLADAGIFTCVAA-SPAG 2200
Query: 197 ISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVA 256
++D + + + VPP L + ++ +V G +EL C+ G P P++ W + D E
Sbjct: 2201 VADRNFTLQVQ---VPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMK-DGEPL 2256
Query: 257 MPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVE-- 314
+ Q S L++ V SG Y C G QL V PP +E
Sbjct: 2257 LSQSLEQGPS----LQLEAVGAGDSGTYSCVAVSEAG----EARRHFQLTVMEPPHIEDS 2308
Query: 315 --PAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAVKSL 372
P L + G + + P +T+ + G L R E A + L
Sbjct: 2309 GQPTELSLTPGAPMELLCDA---QGTPQPNITWH-KDGQALTRL------ENNSRATRVL 2358
Query: 373 SNENYGVYNCSIINEAGAGRCSFLVTGKA 401
+ G+Y C + AGA SF V +A
Sbjct: 2359 RVRDAGLYTCLAESPAGAIEKSFRVRVQA 2387
Score = 92.4 bits (228), Expect = 1e-18
Identities = 105/392 (26%), Positives = 167/392 (42%), Gaps = 49/392 (12%)
Query: 11 ASPSIKLLVDDPIVVNP--GEAITLVCVTTGGEPAPSLTWVR---SFGTLPEKTVLNGGT 65
ASP +K L P VV E + L C +G P P++TW + + T VL GG
Sbjct: 2755 ASPVVKPL---PSVVRAVAEEEVLLPCEASG-IPRPTITWQKEGLNVATGVSTQVLPGGQ 2810
Query: 66 LTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVR---ALKKGRFWITPDPYHKDDNIQI 122
L I + +DAG Y CIA N+ G+ A T ++V+ ++ G D +
Sbjct: 2811 LRIAHASPEDAGNYLCIAKNSAGS-AMGKTRLVVQVPPVIENGL---------PDLSTTE 2860
Query: 123 GREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTD 182
G + C+ P +T W K+G+P+ +E Q + L + +L+ D
Sbjct: 2861 GSHAFLPCKARGSPEPNIT--WDKDGQPVSGAEGKFTIQPSGE-------LLVKNLEGQD 2911
Query: 183 FGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKP 242
GTYTC A + V+++ +P T+P ++S R GD + L+C G P
Sbjct: 2912 AGTYTCTAE---NAVGRARRRVHLTILVLPVFTTLPGDRS---LRLGDRLWLRCAARGSP 2965
Query: 243 KPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREAL 302
P I W+ D+ V +G + + TL+ VSRE SG Y C V +A+
Sbjct: 2966 TPRIGWTVNDRPVT--EGVSEQDG-GSTLQRAAVSREDSGTYVCWAEN----RVGRTQAV 3018
Query: 303 VQLIVQYPPAVE-PAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDS 361
+ V+ P ++ AF + + S+ + C V+R P+ + W LR
Sbjct: 3019 SFVHVKEAPVLQGEAFSYLVEPVGGSIQLDC-VVRGDPVPDI--HWIKDGLPLRGSHLRH 3075
Query: 362 Q-EYTEYAVKSLSNENYGVYNCSIINEAGAGR 392
Q + + ++ G Y C NE G +
Sbjct: 3076 QLQNGSLTIHRTERDDAGRYQCLAENEMGVAK 3107
Score = 87.0 bits (214), Expect = 5e-17
Identities = 98/375 (26%), Positives = 160/375 (42%), Gaps = 43/375 (11%)
Query: 38 TGGEPAPSLTWVRSFGTLP---EKTVLNGG-TLTIPAITSDDAGTYSCIANNNVGNPAKK 93
T P P LTW R L E +VL GG L IP + +++AG YSC A+N VG
Sbjct: 1583 TNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLH 1642
Query: 94 STNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRS 153
+++ I D + + + +S Q A+ + T SW +NG P
Sbjct: 1643 YELLVLTPPV-----ILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSP 1697
Query: 154 SERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDI-SIDVNISSSTVP 212
S R+ + + D V L + + D +Y CVA + G + ++ V VP
Sbjct: 1698 SPRLQVLE-DGQV------LQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQ-----VP 1745
Query: 213 PNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLR 272
P + + + ++ L C V P P + W + + +++ + + TL+
Sbjct: 1746 PRI-AGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPG-THTLQ 1803
Query: 273 IVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPA------FLEIRQGQDR 326
+ SGMY C+ G + K LVQL V PPA A + +R G D+
Sbjct: 1804 LGRARLSDSGMYTCEALNAAGRDQK----LVQLSVLVPPAFRQAPRGPQDAVLVRVG-DK 1858
Query: 327 SVTMSCRVLRAYPIRVLTYEWRLGNKLL---RTGQFDSQEYTEYAVKSLSNENYGVYNCS 383
+V +SC A P +T+ ++ G L+ RT + E +S++ G+Y+C
Sbjct: 1859 AV-LSCET-DALPEPTVTW-YKDGQPLVLAQRTQALRGGQRLEIQEAQVSDK--GLYSCK 1913
Query: 384 IINEAGAGRCSFLVT 398
+ N AG +F +T
Sbjct: 1914 VSNVAGEAVRTFTLT 1928
Score = 85.9 bits (211), Expect = 1e-16
Identities = 103/394 (26%), Positives = 163/394 (41%), Gaps = 59/394 (14%)
Query: 22 PIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTL-----PEKTVLNGG-TLTIPAITSDD 75
P++VN + L C TG P+P+L W++ + P V GG LT+ + + D
Sbjct: 797 PVLVNT--PVRLTCNATGA-PSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASD 853
Query: 76 AGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQI--GREVKISCQVE 133
+G YSC+A + VG + +++++ + P ++ N+ + V + CQ
Sbjct: 854 SGRYSCVAVSAVGEDRQ---DVVLQV------HMPPSILGEELNVSVVANESVALECQSH 904
Query: 134 AVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLK 193
A+P L SW+K+GRPL + +S L + D G YTC A L
Sbjct: 905 AMPPPVL--SWWKDGRPLEPRPGV-------HLSADKALLQVDRADVWDAGHYTCEA-LN 954
Query: 194 GGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADK 253
G S+ ++N+ + V P +E L REG L C+ G P P I W + +
Sbjct: 955 QAGRSEKHYNLNVWVAPVFPL----RESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQ 1010
Query: 254 EVAMPDGSMQMESYDGTLRIVNVSR-EMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPA 312
+ +Q S G L + ++ G Y C+ S G + + +QL V PP
Sbjct: 1011 PLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQD----LQLEVHVPPQ 1066
Query: 313 V----EPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYE-------WRLGNKLLRTGQFDS 361
+ EP ++ QD T+ C P +T+E LG +L GQ
Sbjct: 1067 IAGPREPP-TQVSVVQDGVATLECNA-TGKPPPTVTWERDGQPVGAELGLQLQNQGQSLH 1124
Query: 362 QEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSF 395
E + A + G Y+C N AG F
Sbjct: 1125 VERAQAA-------HTGRYSCVAENLAGRAERKF 1151
Score = 84.3 bits (207), Expect = 4e-16
Identities = 95/390 (24%), Positives = 158/390 (40%), Gaps = 46/390 (11%)
Query: 23 IVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLN----GGTLTIPAITSDDAGT 78
+ V E++ L C + P P L+W + L + ++ L + DAG
Sbjct: 889 VSVVANESVALEC-QSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGH 947
Query: 79 YSCIANNNVGNPAKKSTNIIVRALKKGRFWITPD-PYHKDDNIQI--GREVKISCQVEAV 135
Y+C A N G ++K N+ V W+ P P + + + G +SC+ V
Sbjct: 948 YTCEALNQAGR-SEKHYNLNV--------WVAPVFPLRESHTLTVREGHPTSLSCECRGV 998
Query: 136 PSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVAS-LKG 194
P ++ SW K+G+PL + VS L + + GTYTC S + G
Sbjct: 999 PFPKI--SWRKDGQPLPGEGAGL-----QHVSAVGRLLYLGQAQLAQEGTYTCECSNVVG 1051
Query: 195 GGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIE-LQCQVTGKPKPIILWSRADK 253
D+ ++V+ VPP + P+E V+ D + L+C TGKP P + W R +
Sbjct: 1052 NSSQDLQLEVH-----VPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQ 1106
Query: 254 EVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAV 313
V G +Q+++ +L + +G Y C G E +L V PP +
Sbjct: 1107 PVGAELG-LQLQNQGQSLHVERAQAAHTGRYSCVAENLAG----RAERKFELSVLVPPEL 1161
Query: 314 ----EPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAV 369
+P I +T+ C + P + W G + + G+ + +
Sbjct: 1162 IGDLDP-LTNITAALHSPLTLLCEAMGIPPPAI---RWFRGEEPVSPGEDTYLLAGGWML 1217
Query: 370 K--SLSNENYGVYNCSIINEAGAGRCSFLV 397
K ++ G+Y+C NEAG R +F V
Sbjct: 1218 KMTQTQEQDSGLYSCLASNEAGEARRNFSV 1247
Score = 83.6 bits (205), Expect = 6e-16
Identities = 102/402 (25%), Positives = 173/402 (43%), Gaps = 52/402 (12%)
Query: 8 NKTASPSIKLLVDDP--IVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLP--EKTVLNG 63
N P+IK D +V PGE +T+VC G P ++W++ LP ++T+L+G
Sbjct: 2115 NVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPI-HVSWLKDGLPLPLSQRTLLHG 2173
Query: 64 G--TLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQ 121
TL I + DAG ++C+A + G A ++ + V+ + P + D +
Sbjct: 2174 SGHTLRISKVQLADAGIFTCVAASPAG-VADRNFTLQVQVPPV----LEPVEFQNDVVVV 2228
Query: 122 IGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFT 181
G V++ C+ VP SW K+G PL S + P +L + +
Sbjct: 2229 RGSLVELPCEARGVPLP--LVSWMKDGEPLLSQS----LEQGP-------SLQLEAVGAG 2275
Query: 182 DFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGK 241
D GTY+CVA + G + + + PP++ + + L G +EL C G
Sbjct: 2276 DSGTYSCVA-VSEAGEARRHFQLTVME---PPHIEDSGQPTELSLTPGAPMELLCDAQGT 2331
Query: 242 PKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREA 301
P+P I W + + + ++E+ R++ V +G+Y C G E
Sbjct: 2332 PQPNITWHKDGQALT------RLENNSRATRVLRV--RDAGLYTCLAESPAG----AIEK 2379
Query: 302 LVQLIVQYPPAV----EPAF-LEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRT 356
++ VQ PP + P F + + GQ + + C V A P +T+ R G L
Sbjct: 2380 SFRVRVQAPPNIVGPRGPRFVVGLAPGQ---LVLECSV-EAEPAPKITWH-RDGIVLQED 2434
Query: 357 GQFDSQEYTEY-AVKSLSNENYGVYNCSIINEAGAGRCSFLV 397
E + +++LS + G Y+C+ N AG+ +F V
Sbjct: 2435 AHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRV 2476
Score = 82.0 bits (201), Expect = 2e-15
Identities = 93/384 (24%), Positives = 156/384 (40%), Gaps = 60/384 (15%)
Query: 23 IVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLNGGTLTIPAITSDDAGTYSCI 82
+VV G + L C G P P ++W++ L +++ G +L + A+ + D+GTYSC+
Sbjct: 2225 VVVVRGSLVELPCEARG-VPLPLVSWMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCV 2283
Query: 83 ANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDD-------NIQIGREVKISCQVEAV 135
A + G A++ + V +P H +D ++ G +++ C +
Sbjct: 2284 AVSEAGE-ARRHFQLTVM-----------EPPHIEDSGQPTELSLTPGAPMELLCDAQGT 2331
Query: 136 PSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGG 195
P +T W K+G+ L E + T + L+ D G YTC+A G
Sbjct: 2332 PQPNIT--WHKDGQALTRLEN----------NSRATRV----LRVRDAGLYTCLAESPAG 2375
Query: 196 GISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEV 255
I + S V + + PPN+ P+ +V + L+C V +P P I W R D V
Sbjct: 2376 AI-EKSFRVRVQA---PPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHR-DGIV 2430
Query: 256 AMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNG-----FNVKPREALVQLIVQYP 310
D Q L++ +S SG Y C G F V+ V I P
Sbjct: 2431 LQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIH--TVPTIRSGP 2488
Query: 311 PAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLL--RTGQFDSQEYTEYA 368
PAV + +++ + C +A + WR L R+ +F+
Sbjct: 2489 PAVNVSV-------NQTALLPC---QADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLR 2538
Query: 369 VKSLSNENYGVYNCSIINEAGAGR 392
++ + ++ G Y C N AG+ R
Sbjct: 2539 IQPVLAQDAGHYLCLASNSAGSDR 2562
Score = 77.8 bits (190), Expect = 3e-14
Identities = 75/270 (27%), Positives = 112/270 (41%), Gaps = 45/270 (16%)
Query: 28 GEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLN--GGTLTIPAITSDDAGTYSCIANN 85
G+ + L C G P P + W + + E G TL A++ +D+GTY C A N
Sbjct: 2952 GDRLWLRCAARGS-PTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAEN 3010
Query: 86 NVGNPAKKSTNIIVRA--LKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFS 143
VG S + A L+ F +P +G +++ C V P ++
Sbjct: 3011 RVGRTQAVSFVHVKEAPVLQGEAFSYLVEP--------VGGSIQLDCVVRGDPVPDI--H 3060
Query: 144 WFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISID 203
W K+G PLR S Q +L I + D G Y C+A + G + I
Sbjct: 3061 WIKDGLPLRGSHLRHQLQNG--------SLTIHRTERDDAGRYQCLAENEMGVAKKVVIL 3112
Query: 204 VNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEV-------A 256
V S+ P PQ+ + R GD + L+CQ TG+P P I W +A + +
Sbjct: 3113 VLQSA---PVFQVEPQD---MTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRT 3166
Query: 257 MPDGSMQMESYDGTLRIVNVSREMSGMYRC 286
+PDGS+ +E NV +G Y C
Sbjct: 3167 LPDGSLWLE---------NVETGDAGTYDC 3187
Score = 76.6 bits (187), Expect = 7e-14
Identities = 76/332 (22%), Positives = 137/332 (41%), Gaps = 35/332 (10%)
Query: 14 SIKLLVDDPIVVNP-------GEAITLVCVTTGGEPAPSLTWVRSFGTLPE----KTVLN 62
++K+LV I P ++TL C+ +G P P ++W + + ++
Sbjct: 688 ALKVLVPPNIEPGPVNKAVLENASVTLECLASG-VPPPDVSWFKGHQPVSSWMGVTVSVD 746
Query: 63 GGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQI 122
G L I DAG+Y C+A+N G+ + +R R + P + +
Sbjct: 747 GRVLRIEQAQLSDAGSYRCVASNVAGSTELRYG---LRVNVPPRITLPPS---LPGPVLV 800
Query: 123 GREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTD 182
V+++C PS T W K+G P+ + + V PG L + + +D
Sbjct: 801 NTPVRLTCNATGAPSP--TLMWLKDGNPVSPAGTPGL-----QVFPGGRVLTLASARASD 853
Query: 183 FGTYTCVA-SLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGK 241
G Y+CVA S G D+ + V+ +PP++ + +V E ++ L+CQ
Sbjct: 854 SGRYSCVAVSAVGEDRQDVVLQVH-----MPPSILGEELNVSVVANE--SVALECQSHAM 906
Query: 242 PKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREA 301
P P++ W + D P + + + L++ +G Y C+ G + K
Sbjct: 907 PPPVLSWWK-DGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGRSEKHYNL 965
Query: 302 LVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCR 333
V + + P E L +R+G S++ CR
Sbjct: 966 NVWVAPVF-PLRESHTLTVREGHPTSLSCECR 996
Score = 75.1 bits (183), Expect = 2e-13
Identities = 93/379 (24%), Positives = 152/379 (40%), Gaps = 42/379 (11%)
Query: 24 VVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLN----GGTLTIPAITSDDAGTY 79
VV G A TL C TG +P P++TW R + + L G +L + + G Y
Sbjct: 1079 VVQDGVA-TLECNATG-KPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRY 1136
Query: 80 SCIANNNVGNPAKK-STNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSE 138
SC+A N G +K +++V G DP NI ++ EA+
Sbjct: 1137 SCVAENLAGRAERKFELSVLVPPELIGDL----DPL---TNITAALHSPLTLLCEAMGIP 1189
Query: 139 ELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGIS 198
WF+ P+ E D + G L + + D G Y+C+AS + G
Sbjct: 1190 PPAIRWFRGEEPVSPGE-------DTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEAR 1242
Query: 199 -DISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAM 257
+ S++V VPP++ + + +G T L C VTG P+P + W + + +A
Sbjct: 1243 RNFSVEV-----LVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLAR 1297
Query: 258 PDGSMQMESYDGT-LRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAV--- 313
G S DG L+++ + +G Y C + G K QL V P +
Sbjct: 1298 --GDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKH----FQLSVLLAPTILGG 1351
Query: 314 --EPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTE-YAVK 370
+ A E+ + +++ C L A+P +T+ + G + T +
Sbjct: 1352 AEDSADEEVTVTVNNPISLICEAL-AFPSPNITW-MKDGAPFEASRNIQLLPGTHGLQIL 1409
Query: 371 SLSNENYGVYNCSIINEAG 389
+ E+ G Y C + NE G
Sbjct: 1410 NAQKEDAGQYTCVVTNELG 1428
Score = 74.7 bits (182), Expect = 3e-13
Identities = 94/385 (24%), Positives = 156/385 (40%), Gaps = 63/385 (16%)
Query: 28 GEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLNGG----------TLTIPAITSDDAG 77
G + L C T+G P P + W + + VL GG L I D G
Sbjct: 232 GADVELQCWTSG-VPTPQVEWTKD-----RQPVLPGGPHLQVQEDGQVLRITGSHVGDEG 285
Query: 78 TYSCIANNNVGNPAKKSTNIIVRALKKGRFW---ITPDPYHKDDNIQIGREVKISCQVEA 134
Y C+A + G A+ + +R W T + +D++ V++ C+
Sbjct: 286 RYQCVAFSPAGQQAR---DFQLRVHAPPTIWGSNETGEVAVMEDHL-----VQLLCEARG 337
Query: 135 VPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKG 194
VP+ +T WFK+G L +S ++V T+ G L + + +D G YTC AS
Sbjct: 338 VPTPNIT--WFKDGALLPTSTKVVYTR-------GGRQLQLGRAQSSDAGVYTCKASNAV 388
Query: 195 GGISDIS-IDVNISSSTVPPNLTVPQEKSPLVTR--EGDTIELQCQVTGKPKPIILWSRA 251
G + +DV VPP + + P V + G + L+C G P P + W
Sbjct: 389 GAAEKATRLDV-----YVPPTIEGAGGR-PYVVKAVAGRPVALECVARGHPSPTLSWHHE 442
Query: 252 DKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPP 311
VA + S ++E+ LR+ + SG+Y C S G + ++QY
Sbjct: 443 GLPVAESNES-RLETDGSVLRLESPGEASSGLYSCVASSPAG----------EAVLQYSV 491
Query: 312 AVE-PAFLEIRQGQDRSVTMSCRVL----RAYPIRVLTYEWRLGNKLLR--TGQFDSQEY 364
V+ P L + +G + T+ + L +A V T +W + G + +
Sbjct: 492 EVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQG 551
Query: 365 TEYAVKSLSNENYGVYNCSIINEAG 389
T + + ++ G++ C NEAG
Sbjct: 552 TTLHIDHVELDHSGLFACQATNEAG 576
Score = 71.6 bits (174), Expect = 2e-12
Identities = 88/348 (25%), Positives = 142/348 (40%), Gaps = 57/348 (16%)
Query: 20 DDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLP--EKTVLNGGT--LTIPAITSDD 75
D+ + V I+L+C P+P++TW++ L GT L I +D
Sbjct: 1357 DEEVTVTVNNPISLICEALAF-PSPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKED 1415
Query: 76 AGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNI-QIG-REVK------ 127
AG Y+C+ N +G K N V L P KDD + ++G +EVK
Sbjct: 1416 AGQYTCVVTNELGEAVK---NYHVEVL-------IPPSISKDDPLGEVGVKEVKTKVNST 1465
Query: 128 --ISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGT 185
+ C+ AVP T W+K+G+P+ S R+ + + G L I + +D G
Sbjct: 1466 LTLECESWAVPPP--TIRWYKDGQPVTPSSRLQV------LGEGRL-LQIQPTQVSDSGR 1516
Query: 186 YTCVA-SLKGGGISDISIDVNI--------SSSTVPPNLTVPQEKSPLVTREGDTIE--- 233
Y CVA ++ G D ++ + + S L+ +E VT + +E
Sbjct: 1517 YLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNP 1576
Query: 234 --LQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQY 291
L C P P + W R D+ ++ D ++ L+I V E +G Y C+ S
Sbjct: 1577 AYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQG-GRVLQIPLVRAENAGRYSCKASNE 1635
Query: 292 NGFNVKPREALVQLIVQYPPAV----EPAFLEIRQGQDRSVTMSCRVL 335
G + E L+V PP + E E+ +V++ C L
Sbjct: 1636 VGEDWLHYE----LLVLTPPVILGDTEELVEEVTVNASSTVSLQCPAL 1679
Score = 67.8 bits (164), Expect = 3e-11
Identities = 92/390 (23%), Positives = 148/390 (37%), Gaps = 54/390 (13%)
Query: 27 PGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLN----GGTLTIPAITSDDAGTYSCI 82
PG+ + L C + EPAP +TW R L E G L + A+++ D+G YSC
Sbjct: 2405 PGQLV-LEC-SVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCT 2462
Query: 83 ANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTF 142
A N G ST++ R I P N+ + + + CQ + VP+ +
Sbjct: 2463 ARNAAG-----STSVAFRVEIHTVPTIRSGP--PAVNVSVNQTALLPCQADGVPAPLV-- 2513
Query: 143 SWFKNGRPL--RSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGIS-- 198
SW K+ PL RS ++ + + P D G Y C+AS G
Sbjct: 2514 SWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQ---------DAGHYLCLASNSAGSDRQG 2564
Query: 199 -DISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAM 257
D+ + + + P NLT+ L L C+ +G PKP+++W + +++
Sbjct: 2565 RDLRVLEPPAIAPSPSNLTLTAHTPAL---------LPCEASGSPKPLVVWWKDGQKL-- 2613
Query: 258 PDGSMQMESY----DGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAV 313
D +Q +Y L + + S + C S V L Q+ V PP +
Sbjct: 2614 -DFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSN----EVGEAHRLYQVTVHVPPTI 2668
Query: 314 EPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEW-RLGNKL-LRTGQFDSQEYTEYAVKS 371
+ V ++C + I T W + G +L R + +
Sbjct: 2669 ADDQTDFTVTMMAPVVLTC---HSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQ 2725
Query: 372 LSNENYGVYNCSIINEAGAGRCSFLVTGKA 401
+ G Y CS N AG +T +A
Sbjct: 2726 ALPIHAGRYTCSARNSAGVAHKHVFLTVQA 2755
Score = 64.7 bits (156), Expect = 3e-10
Identities = 92/398 (23%), Positives = 156/398 (39%), Gaps = 47/398 (11%)
Query: 13 PSIKLLVDDPIVVNP--GEAITLVCVTTGGEPAPSLTWVRSFGTLPE----KTVLNGGTL 66
P+I+ P VV G + L CV G P+P+L+W + E + +G L
Sbjct: 403 PTIEGAGGRPYVVKAVAGRPVALECVARG-HPSPTLSWHHEGLPVAESNESRLETDGSVL 461
Query: 67 TIPAITSDDAGTYSCIANNNVGNPAKK-STNIIVRA---LKKGRFWITPDPYHKDDNIQI 122
+ + +G YSC+A++ G + S + V + +G +T +
Sbjct: 462 RLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTI---------V 512
Query: 123 GREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTD 182
G+ +++ CQ P T W +NGRP +E + Q S GTT L I ++
Sbjct: 513 GQPLELPCQASGSPVP--TIQWLQNGRP---AEELAGVQV---ASQGTT-LHIDHVELDH 563
Query: 183 FGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVT--- 239
G + C A+ + G + ++V++ P L VP + + C
Sbjct: 564 SGLFACQATNEAG-TAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHR 622
Query: 240 ---GKPKPIIL--WSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGF 294
PKP ++ W P G S L+I V G+Y C + G
Sbjct: 623 GWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGE 682
Query: 295 NVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLL 354
+ RE ++++V PP +EP + ++ SVT+ C P V W G++ +
Sbjct: 683 S--KREVALKVLV--PPNIEPGPVNKAVLENASVTLECLASGVPPPDV---SWFKGHQPV 735
Query: 355 RT--GQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGA 390
+ G S + ++ + G Y C N AG+
Sbjct: 736 SSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGS 773
Score = 57.4 bits (137), Expect = 5e-08
Identities = 85/385 (22%), Positives = 141/385 (36%), Gaps = 52/385 (13%)
Query: 38 TGGEPAPSLTWVRSFGT-----LPEKTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAK 92
T G P P +TW + + P VL G+L + +++ D+G Y C A N VG+ ++
Sbjct: 26 THGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGSTSR 85
Query: 93 KSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKN----G 148
++ ++ I D + + G+ + + C P E+ W K+ G
Sbjct: 86 RAKLVVYVPPS-----IREDGRKANVSGMAGQSLTLECDANGFPVPEIV--WLKDAQLVG 138
Query: 149 RPLR-------------SSERMVITQTD---PDVSPGTTNLDIIDLKFTDFGTYTCVASL 192
PL R++ P + PG + + A L
Sbjct: 139 VPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQPGRSGRRGAQAGGSAQTKAPWXAGL 198
Query: 193 KGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRAD 252
G + + S PP++ ++ G +ELQC +G P P + W++ D
Sbjct: 199 AG---FEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTK-D 254
Query: 253 KEVAMPDG-SMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPP 311
++ +P G +Q++ LRI G Y+C G + QL V PP
Sbjct: 255 RQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARD----FQLRVHAPP 310
Query: 312 AV--EPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYT---- 365
+ E+ +D V + C R P +T W LL T YT
Sbjct: 311 TIWGSNETGEVAVMEDHLVQLLCEA-RGVPTPNIT--WFKDGALLPTS--TKVVYTRGGR 365
Query: 366 EYAVKSLSNENYGVYNCSIINEAGA 390
+ + + + GVY C N GA
Sbjct: 366 QLQLGRAQSSDAGVYTCKASNAVGA 390
Score = 45.4 bits (106), Expect = 2e-04
Identities = 26/86 (30%), Positives = 47/86 (54%), Gaps = 5/86 (5%)
Query: 23 IVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKT---VLNGGTLTIPAITSDDAGTY 79
+ V G+ + L C TG EP P++ W+++ L L G+L + + + DAGTY
Sbjct: 3127 MTVRSGDDVALRCQATG-EPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTY 3185
Query: 80 SCIANNNVGNPAKKSTNIIVRALKKG 105
C+A+N +G+ ++ ++VR +G
Sbjct: 3186 DCVAHNLLGSATARAF-LVVRGEPQG 3210
Score = 37.4 bits (85), Expect = 0.050
Identities = 29/131 (22%), Positives = 53/131 (40%), Gaps = 12/131 (9%)
Query: 130 CQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCV 189
C P ++T+ + PL + + + +L + + D G Y C
Sbjct: 24 CGTHGTPKPQVTWRKGPSSEPLHGQPGVAVLEEG--------SLFLASVSPADSGDYECQ 75
Query: 190 ASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWS 249
A+ + G S + V VPP++ K+ + G ++ L+C G P P I+W
Sbjct: 76 ATNEVGSTSRRAKLVVY----VPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWL 131
Query: 250 RADKEVAMPDG 260
+ + V +P G
Sbjct: 132 KDAQLVGVPLG 142
Score = 33.1 bits (74), Expect = 0.94
Identities = 20/78 (25%), Positives = 32/78 (41%), Gaps = 4/78 (5%)
Query: 236 CQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFN 295
C G PKP + W + + +G+L + +VS SG Y CQ +
Sbjct: 24 CGTHGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATN----E 79
Query: 296 VKPREALVQLIVQYPPAV 313
V +L+V PP++
Sbjct: 80 VGSTSRRAKLVVYVPPSI 97
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 95.1 bits (235), Expect = 2e-19
Identities = 95/384 (24%), Positives = 169/384 (44%), Gaps = 46/384 (11%)
Query: 28 GEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTV----LNGGTLTIPAITSDDAGTYSCIA 83
G + L C G PAP++TW++ + V GG L + + AGTY+C+A
Sbjct: 3139 GSPLVLTC-DVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVA 3197
Query: 84 NNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFS 143
N A+ + +V L R I ++ ++ G+EV++ C+ + P ++ +
Sbjct: 3198 EN---TQAEARKDFVVAVLVAPR--IRSSGVAREHHVLEGQEVRLDCEADGQPPPDV--A 3250
Query: 144 WFKNGRPLRSSERMVITQTDPDVSPGTT------NLDIIDLKFTDFGTYTCVASLKGGGI 197
W K+G PL D+ P +L + L+ +D G YTCVA G
Sbjct: 3251 WLKDGSPL-----------GQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGED 3299
Query: 198 SDISIDVNISSSTVPPNLTVPQEKS-PLVTREGDTIELQCQVTGKPKPIILWSRADKEVA 256
+ + VN+ VPP + + S LV+R G+ + + C V G P + W + +
Sbjct: 3300 ARLH-TVNV---LVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLP 3355
Query: 257 MPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPA 316
+ ++ + TLRI V +G++ C + G V R +Q VQ PP +EP
Sbjct: 3356 LSQRTL-LHGSGHTLRISKVQLADAGIFTCVAASPAG--VADRNFTLQ--VQVPPVLEPV 3410
Query: 317 FL--EIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAVKSLSN 374
++ + V + C R P+ ++++ + G LL ++ ++++
Sbjct: 3411 EFQNDVVVVRGSLVELPCEA-RGVPLPLVSW-MKDGEPLLSQ---SLEQGPSLQLEAVGA 3465
Query: 375 ENYGVYNCSIINEAGAGRCSFLVT 398
+ G Y+C ++EAG R F +T
Sbjct: 3466 GDSGTYSCVAVSEAGEARRHFQLT 3489
Score = 94.0 bits (232), Expect = 4e-19
Identities = 94/319 (29%), Positives = 135/319 (42%), Gaps = 55/319 (17%)
Query: 23 IVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVL----NGGTLTIPAITSDDAGT 78
+ V + L+C G P P++TW + LP T + G L + S DAG
Sbjct: 1512 VAVMEDHLVQLLCEARG-VPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGV 1570
Query: 79 YSCIANNNVGNPAKKSTNIIVRALKK-----GRFWITPDPYHKDDNIQIGREVKISCQVE 133
Y+C A+N VG A+K+T + V GR ++ GR V + C
Sbjct: 1571 YTCKASNAVG-AAEKATRLDVYVPPTIEGAGGRPYVV--------KAVAGRPVALECVAR 1621
Query: 134 AVPSEELTFSWFKNGRPLRSSERMVITQTDPDV----SPGTTNLDIIDLKFTDFGTYTCV 189
PS T SW G P+ S + +TD V SPG + G Y+CV
Sbjct: 1622 GHPSP--TLSWHHEGLPVAESNESRL-ETDGSVLRLESPGEASS----------GLYSCV 1668
Query: 190 ASLKGG-GISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILW 248
AS G + S++V VPP L V + + T G +EL CQ +G P P I W
Sbjct: 1669 ASSPAGEAVLQYSVEVQ-----VPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQW 1723
Query: 249 ---SRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQL 305
R +E+A +Q+ S TL I +V + SG++ CQ + N E V +
Sbjct: 1724 LQNGRPAEELA----GVQVASQGTTLHIDHVELDHSGLFACQAT--NEAGTAGAEVEVSV 1777
Query: 306 IVQYPPAVEPAFLEIRQGQ 324
++ P V LE+ GQ
Sbjct: 1778 HGEWAPGV----LEVPIGQ 1792
Score = 93.6 bits (231), Expect = 6e-19
Identities = 103/389 (26%), Positives = 162/389 (41%), Gaps = 57/389 (14%)
Query: 28 GEAITLVCVTTGGEPAPSLTWVRSFGTLPE------KTVLNGGTLTIPAITSDDAGTYSC 81
G+ + L C G+P P + W++ L + + L+GG+L + + + DAG Y+C
Sbjct: 3232 GQEVRLDC-EADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTC 3290
Query: 82 IANNNVGNPAKKST-NIIVRALKK----GRFWITPDPYHKDDNIQIGREVKISCQVEAVP 136
+A+N G A+ T N++V K G + P G V + C V P
Sbjct: 3291 VAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRP---------GELVTMVCPVRGSP 3341
Query: 137 SEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGG 196
+ SW K+G PL S+R ++ G T L I ++ D G +TCVA+ G
Sbjct: 3342 --PIHVSWLKDGLPLPLSQRTLLH------GSGHT-LRISKVQLADAGIFTCVAA-SPAG 3391
Query: 197 ISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVA 256
++D + + + VPP L + ++ +V G +EL C+ G P P++ W + D E
Sbjct: 3392 VADRNFTLQVQ---VPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMK-DGEPL 3447
Query: 257 MPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVE-- 314
+ Q S L++ V SG Y C G QL V PP +E
Sbjct: 3448 LSQSLEQGPS----LQLEAVGAGDSGTYSCVAVSEAG----EARRHFQLTVMEPPHIEDS 3499
Query: 315 --PAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAVKSL 372
P L + G + + P +T+ + G L R E A + L
Sbjct: 3500 GQPTELSLTPGAPMELLCDA---QGTPQPNITWH-KDGQALTRL------ENNSRATRVL 3549
Query: 373 SNENYGVYNCSIINEAGAGRCSFLVTGKA 401
+ G+Y C + AGA SF V +A
Sbjct: 3550 RVRDAGLYTCLAESPAGAIEKSFRVRVQA 3578
Score = 92.4 bits (228), Expect = 1e-18
Identities = 105/392 (26%), Positives = 167/392 (42%), Gaps = 49/392 (12%)
Query: 11 ASPSIKLLVDDPIVVNP--GEAITLVCVTTGGEPAPSLTWVR---SFGTLPEKTVLNGGT 65
ASP +K L P VV E + L C +G P P++TW + + T VL GG
Sbjct: 3946 ASPVVKPL---PSVVRAVAEEEVLLPCEASG-IPRPTITWQKEGLNVATGVSTQVLPGGQ 4001
Query: 66 LTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVR---ALKKGRFWITPDPYHKDDNIQI 122
L I + +DAG Y CIA N+ G+ A T ++V+ ++ G D +
Sbjct: 4002 LRIAHASPEDAGNYLCIAKNSAGS-AMGKTRLVVQVPPVIENGL---------PDLSTTE 4051
Query: 123 GREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTD 182
G + C+ P +T W K+G+P+ +E Q + L + +L+ D
Sbjct: 4052 GSHAFLPCKARGSPEPNIT--WDKDGQPVSGAEGKFTIQPSGE-------LLVKNLEGQD 4102
Query: 183 FGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKP 242
GTYTC A + V+++ +P T+P ++S R GD + L+C G P
Sbjct: 4103 AGTYTCTAE---NAVGRARRRVHLTILVLPVFTTLPGDRS---LRLGDRLWLRCAARGSP 4156
Query: 243 KPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREAL 302
P I W+ D+ V +G + + TL+ VSRE SG Y C V +A+
Sbjct: 4157 TPRIGWTVNDRPVT--EGVSEQDG-GSTLQRAAVSREDSGTYVCWAEN----RVGRTQAV 4209
Query: 303 VQLIVQYPPAVE-PAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDS 361
+ V+ P ++ AF + + S+ + C V+R P+ + W LR
Sbjct: 4210 SFVHVKEAPVLQGEAFSYLVEPVGGSIQLDC-VVRGDPVPDI--HWIKDGLPLRGSHLRH 4266
Query: 362 Q-EYTEYAVKSLSNENYGVYNCSIINEAGAGR 392
Q + + ++ G Y C NE G +
Sbjct: 4267 QLQNGSLTIHRTERDDAGRYQCLAENEMGVAK 4298
Score = 89.7 bits (221), Expect = 8e-18
Identities = 101/404 (25%), Positives = 161/404 (39%), Gaps = 51/404 (12%)
Query: 13 PSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKT----VLNGGTLTI 68
P +L+ + V+PGE L C G P +LTWVR + LP T L +L I
Sbjct: 516 PPPQLVPAPNVTVSPGETAVLSCRVLGEAPY-NLTWVRDWRVLPASTGRVAQLADLSLEI 574
Query: 69 PAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKI 128
I D G Y C+A+N G + S ++VR + + + G EVK+
Sbjct: 575 SGIIPTDGGRYQCVASNANG-VTRASVWLLVREAPQVSI------HTSSQHFSQGVEVKV 627
Query: 129 SCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTC 188
SC P+ + SW + + L+ R+ + + GT L I + D G Y+C
Sbjct: 628 SCSASGYPTPHI--SWSRESQALQEDSRIHVD------AQGT--LIIQGVAPEDAGNYSC 677
Query: 189 VASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILW 248
A+ +++ D + +V + ++ G+ L C+ +G P P ++W
Sbjct: 678 QAT------NEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIW 731
Query: 249 SRADKEVAM-PDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIV 307
R E+ + P+GS G LRI +G Y C+ G A +QL V
Sbjct: 732 YRGGLEMILAPEGSS-----SGKLRIPAAQERDAGTYTCRAVNELG----DASAEIQLAV 782
Query: 308 QYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGN-----KLLRTGQFDSQ 362
+ P + ++ RS ++CR P T WR G+ L G+
Sbjct: 783 GHAPQLTELPRDVTVELGRSALLACRATGRPP---PTVTWRRGDGQPLGLRLGAGRGSRS 839
Query: 363 EYTEYAV---KSLSNENYGVYNCSIINEAG--AGRCSFLVTGKA 401
+ V +S++ E+ Y C N G +VTG A
Sbjct: 840 RQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHA 883
Score = 89.4 bits (220), Expect = 1e-17
Identities = 91/374 (24%), Positives = 151/374 (40%), Gaps = 54/374 (14%)
Query: 34 VCVTTGGEPAPSLTWVRSFGTLPEKTVLN---GGTLTIPAITSDDAGTYSCIANNNVGNP 90
V + G P P ++W R L E + ++ GTL I + +DAG YSC A N VG
Sbjct: 627 VSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTD 686
Query: 91 AKKSTNIIVRALKKGRFWITPDPYHKDDN----IQIGREVKISCQVEAVPSEELTFSWFK 146
+ T + T P N + +G E + C+ VP + W++
Sbjct: 687 QETVT-----------LYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVI--WYR 733
Query: 147 NGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNI 206
G M++ P+ S + L I + D GTYTC A + D S ++ +
Sbjct: 734 GGL------EMILA---PEGS-SSGKLRIPAAQERDAGTYTCRAV---NELGDASAEIQL 780
Query: 207 SSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKE-----VAMPDGS 261
+ P +P++ + G + L C+ TG+P P + W R D + + GS
Sbjct: 781 AVGHAPQLTELPRD---VTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGS 837
Query: 262 MQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIR 321
+ G L +V+ E Y C+ N F EA + + PP + + +R
Sbjct: 838 RSRQPDSGVLFFESVAPEDQAPYVCEAR--NVFGKVQAEARLIVTGHAPPQIASSAPTVR 895
Query: 322 QGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTG-----QFDSQEYTEYAVKSLSNEN 376
+ + V++ C VL P+ W + L G + D + + A++ E+
Sbjct: 896 VLEGQPVSLPCIVLAGRPLP--ERHWLKDGRPLPPGSRHSIRADGSLHLDRALQ----EH 949
Query: 377 YGVYNCSIINEAGA 390
G Y+C N AG+
Sbjct: 950 AGRYSCVATNTAGS 963
Score = 87.0 bits (214), Expect = 5e-17
Identities = 98/375 (26%), Positives = 160/375 (42%), Gaps = 43/375 (11%)
Query: 38 TGGEPAPSLTWVRSFGTLP---EKTVLNGG-TLTIPAITSDDAGTYSCIANNNVGNPAKK 93
T P P LTW R L E +VL GG L IP + +++AG YSC A+N VG
Sbjct: 2774 TNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLH 2833
Query: 94 STNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRS 153
+++ I D + + + +S Q A+ + T SW +NG P
Sbjct: 2834 YELLVLTPPV-----ILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSP 2888
Query: 154 SERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDI-SIDVNISSSTVP 212
S R+ + + D V L + + D +Y CVA + G + ++ V VP
Sbjct: 2889 SPRLQVLE-DGQV------LQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQ-----VP 2936
Query: 213 PNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLR 272
P + + + ++ L C V P P + W + + +++ + + TL+
Sbjct: 2937 PRI-AGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPG-THTLQ 2994
Query: 273 IVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPA------FLEIRQGQDR 326
+ SGMY C+ G + K LVQL V PPA A + +R G D+
Sbjct: 2995 LGRARLSDSGMYTCEALNAAGRDQK----LVQLSVLVPPAFRQAPRGPQDAVLVRVG-DK 3049
Query: 327 SVTMSCRVLRAYPIRVLTYEWRLGNKLL---RTGQFDSQEYTEYAVKSLSNENYGVYNCS 383
+V +SC A P +T+ ++ G L+ RT + E +S++ G+Y+C
Sbjct: 3050 AV-LSCET-DALPEPTVTW-YKDGQPLVLAQRTQALRGGQRLEIQEAQVSDK--GLYSCK 3104
Query: 384 IINEAGAGRCSFLVT 398
+ N AG +F +T
Sbjct: 3105 VSNVAGEAVRTFTLT 3119
Score = 85.9 bits (211), Expect = 1e-16
Identities = 103/394 (26%), Positives = 163/394 (41%), Gaps = 59/394 (14%)
Query: 22 PIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTL-----PEKTVLNGG-TLTIPAITSDD 75
P++VN + L C TG P+P+L W++ + P V GG LT+ + + D
Sbjct: 1988 PVLVNT--PVRLTCNATGA-PSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASD 2044
Query: 76 AGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQI--GREVKISCQVE 133
+G YSC+A + VG + +++++ + P ++ N+ + V + CQ
Sbjct: 2045 SGRYSCVAVSAVGEDRQ---DVVLQV------HMPPSILGEELNVSVVANESVALECQSH 2095
Query: 134 AVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLK 193
A+P L SW+K+GRPL + +S L + D G YTC A L
Sbjct: 2096 AMPPPVL--SWWKDGRPLEPRPGV-------HLSADKALLQVDRADVWDAGHYTCEA-LN 2145
Query: 194 GGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADK 253
G S+ ++N+ + V P +E L REG L C+ G P P I W + +
Sbjct: 2146 QAGHSEKHYNLNVWVAPVFPL----RESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQ 2201
Query: 254 EVAMPDGSMQMESYDGTLRIVNVSR-EMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPA 312
+ +Q S G L + ++ G Y C+ S G + + +QL V PP
Sbjct: 2202 PLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQD----LQLEVHVPPQ 2257
Query: 313 V----EPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYE-------WRLGNKLLRTGQFDS 361
+ EP ++ QD T+ C P +T+E LG +L GQ
Sbjct: 2258 IAGPREPP-TQVSVVQDGVATLECNA-TGKPPPTVTWERDGQPVGAELGLQLQNQGQSLH 2315
Query: 362 QEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSF 395
E + A + G Y+C N AG F
Sbjct: 2316 VERAQAA-------HTGRYSCVAENLAGRAERKF 2342
Score = 84.7 bits (208), Expect = 3e-16
Identities = 95/390 (24%), Positives = 159/390 (40%), Gaps = 46/390 (11%)
Query: 23 IVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLN----GGTLTIPAITSDDAGT 78
+ V E++ L C + P P L+W + L + ++ L + DAG
Sbjct: 2080 VSVVANESVALEC-QSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGH 2138
Query: 79 YSCIANNNVGNPAKKSTNIIVRALKKGRFWITPD-PYHKDDNIQI--GREVKISCQVEAV 135
Y+C A N G+ ++K N+ V W+ P P + + + G +SC+ V
Sbjct: 2139 YTCEALNQAGH-SEKHYNLNV--------WVAPVFPLRESHTLTVREGHPTSLSCECRGV 2189
Query: 136 PSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVAS-LKG 194
P ++ SW K+G+PL + VS L + + GTYTC S + G
Sbjct: 2190 PFPKI--SWRKDGQPLPGEGAGL-----QHVSAVGRLLYLGQAQLAQEGTYTCECSNVVG 2242
Query: 195 GGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIE-LQCQVTGKPKPIILWSRADK 253
D+ ++V+ VPP + P+E V+ D + L+C TGKP P + W R +
Sbjct: 2243 NSSQDLQLEVH-----VPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQ 2297
Query: 254 EVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAV 313
V G +Q+++ +L + +G Y C G E +L V PP +
Sbjct: 2298 PVGAELG-LQLQNQGQSLHVERAQAAHTGRYSCVAENLAG----RAERKFELSVLVPPEL 2352
Query: 314 ----EPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAV 369
+P I +T+ C + P + W G + + G+ + +
Sbjct: 2353 IGDLDP-LTNITAALHSPLTLLCEAMGIPPPAI---RWFRGEEPVSPGEDTYLLAGGWML 2408
Query: 370 K--SLSNENYGVYNCSIINEAGAGRCSFLV 397
K ++ G+Y+C NEAG R +F V
Sbjct: 2409 KMTQTQEQDSGLYSCLASNEAGEARRNFSV 2438
Score = 83.6 bits (205), Expect = 6e-16
Identities = 102/402 (25%), Positives = 173/402 (43%), Gaps = 52/402 (12%)
Query: 8 NKTASPSIKLLVDDP--IVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLP--EKTVLNG 63
N P+IK D +V PGE +T+VC G P ++W++ LP ++T+L+G
Sbjct: 3306 NVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPI-HVSWLKDGLPLPLSQRTLLHG 3364
Query: 64 G--TLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQ 121
TL I + DAG ++C+A + G A ++ + V+ + P + D +
Sbjct: 3365 SGHTLRISKVQLADAGIFTCVAASPAG-VADRNFTLQVQVPPV----LEPVEFQNDVVVV 3419
Query: 122 IGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFT 181
G V++ C+ VP SW K+G PL S + P +L + +
Sbjct: 3420 RGSLVELPCEARGVPLP--LVSWMKDGEPLLSQS----LEQGP-------SLQLEAVGAG 3466
Query: 182 DFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGK 241
D GTY+CVA + G + + + PP++ + + L G +EL C G
Sbjct: 3467 DSGTYSCVA-VSEAGEARRHFQLTVME---PPHIEDSGQPTELSLTPGAPMELLCDAQGT 3522
Query: 242 PKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREA 301
P+P I W + + + ++E+ R++ V +G+Y C G E
Sbjct: 3523 PQPNITWHKDGQALT------RLENNSRATRVLRV--RDAGLYTCLAESPAG----AIEK 3570
Query: 302 LVQLIVQYPPAV----EPAF-LEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRT 356
++ VQ PP + P F + + GQ + + C V A P +T+ R G L
Sbjct: 3571 SFRVRVQAPPNIVGPRGPRFVVGLAPGQ---LVLECSV-EAEPAPKITWH-RDGIVLQED 3625
Query: 357 GQFDSQEYTEY-AVKSLSNENYGVYNCSIINEAGAGRCSFLV 397
E + +++LS + G Y+C+ N AG+ +F V
Sbjct: 3626 AHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRV 3667
Score = 82.0 bits (201), Expect = 2e-15
Identities = 93/384 (24%), Positives = 156/384 (40%), Gaps = 60/384 (15%)
Query: 23 IVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLNGGTLTIPAITSDDAGTYSCI 82
+VV G + L C G P P ++W++ L +++ G +L + A+ + D+GTYSC+
Sbjct: 3416 VVVVRGSLVELPCEARG-VPLPLVSWMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCV 3474
Query: 83 ANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDD-------NIQIGREVKISCQVEAV 135
A + G A++ + V +P H +D ++ G +++ C +
Sbjct: 3475 AVSEAGE-ARRHFQLTVM-----------EPPHIEDSGQPTELSLTPGAPMELLCDAQGT 3522
Query: 136 PSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGG 195
P +T W K+G+ L E + T + L+ D G YTC+A G
Sbjct: 3523 PQPNIT--WHKDGQALTRLEN----------NSRATRV----LRVRDAGLYTCLAESPAG 3566
Query: 196 GISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEV 255
I + S V + + PPN+ P+ +V + L+C V +P P I W R D V
Sbjct: 3567 AI-EKSFRVRVQA---PPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHR-DGIV 3621
Query: 256 AMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNG-----FNVKPREALVQLIVQYP 310
D Q L++ +S SG Y C G F V+ V I P
Sbjct: 3622 LQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIH--TVPTIRSGP 3679
Query: 311 PAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLL--RTGQFDSQEYTEYA 368
PAV + +++ + C +A + WR L R+ +F+
Sbjct: 3680 PAVNVSV-------NQTALLPC---QADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLR 3729
Query: 369 VKSLSNENYGVYNCSIINEAGAGR 392
++ + ++ G Y C N AG+ R
Sbjct: 3730 IQPVLAQDAGHYLCLASNSAGSDR 3753
Score = 81.6 bits (200), Expect = 2e-15
Identities = 95/386 (24%), Positives = 158/386 (40%), Gaps = 33/386 (8%)
Query: 10 TASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTL---PEKTVLNGGTL 66
T PS+ V+ ++V GE LVC +G P P + W R + PE + + G L
Sbjct: 695 TDPPSVSA-VNAVVLVAVGEEAVLVCEASG-VPPPRVIWYRGGLEMILAPEGS--SSGKL 750
Query: 67 TIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREV 126
IPA DAGTY+C A N +G+ + + + A + +T P +D +++GR
Sbjct: 751 RIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQ-----LTELP--RDVTVELGRSA 803
Query: 127 KISCQVEAVPSEELTFSWFK-NGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGT 185
++C+ P +T W + +G+PL R+ + P + L + D
Sbjct: 804 LLACRATGRPPPTVT--WRRGDGQPL--GLRLGAGRGSRSRQPDSGVLFFESVAPEDQAP 859
Query: 186 YTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLV-TREGDTIELQCQV-TGKPK 243
Y C A G + + I + PP + +P V EG + L C V G+P
Sbjct: 860 YVCEARNVFGKVQAEAR--LIVTGHAPPQIA---SSAPTVRVLEGQPVSLPCIVLAGRPL 914
Query: 244 PIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALV 303
P W + + +P GS DG+L + +E +G Y C + G + V
Sbjct: 915 PERHWLKDGRP--LPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRD----V 968
Query: 304 QLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQE 363
+L+VQ PP + P + ++ C V P +T+ R ++ +
Sbjct: 969 ELVVQVPPRIHPTATHHITNEGVPASLPC-VASGVPAPTITWTKETNALTSRGPHYNVSK 1027
Query: 364 YTEYAVKSLSNENYGVYNCSIINEAG 389
+ S ++ G Y C+ N G
Sbjct: 1028 EGTLLIAQPSAQDAGAYVCTATNTVG 1053
Score = 79.0 bits (193), Expect = 1e-14
Identities = 99/437 (22%), Positives = 157/437 (35%), Gaps = 88/437 (20%)
Query: 24 VVNPGEAITLVCVTTGGEPAPSLTWVRSFGTL----PEKTVLNGGTLTIPAITSDDAGTY 79
+ N G +L CV +G PAP++TW + L P V GTL I ++ DAG Y
Sbjct: 986 ITNEGVPASLPCVASG-VPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAY 1044
Query: 80 SCIANNNVGNPAKKSTNIIVRALKKGRFW----ITPDPYHKDDNIQIGREVKISC----- 130
C A N VG +++ + R W + P + +Q+G C
Sbjct: 1045 VCTATNTVGFSSQEMRLSVNRLALSKYVWEEYGLLPSGSLRLAQVQVGDSGHYECTASNP 1104
Query: 131 ----------------QVEAVP-------SEELTFSWFKNGRPLR----SSERMVITQTD 163
QV+ P E L + G P S + +V+
Sbjct: 1105 AGSASHRYVLGVQVPPQVQPGPRVLKVLVGEALDLNCVAEGNPEPQLSWSKDGVVLQGRG 1164
Query: 164 PDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSP 223
P S + ++ +D G Y C AS G+ +++ + PP+ +
Sbjct: 1165 PQGS-----VHFAAIRTSDAGRYRCEAS-NSAGVDAWEVELRVLE---PPHWGADETSGL 1215
Query: 224 LVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGM 283
L G+ L C G PKP + W + + +G+L + +VS SG
Sbjct: 1216 LERVAGENASLPCPARGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGD 1275
Query: 284 YRCQTSQYNGFNVKPREALVQLIVQYPPAVEP----AFLEIRQGQDRSVTMSCRV----- 334
Y CQ + G + +L+V PP++ A + GQ S+T+ C
Sbjct: 1276 YECQATNEVGSTSRR----AKLVVYVPPSIREDGRKANVSGMAGQ--SLTLECDANGFPV 1329
Query: 335 ----------LRAYPIRVLTYEWRLG------NKLLRTGQFDSQEYTEYAVKSLSNENYG 378
L P+ Y W LG ++LL GQ + + G
Sbjct: 1330 PEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQ-------SLHFPRIQEGDSG 1382
Query: 379 VYNCSIINEAGAGRCSF 395
+Y+C N+AG + F
Sbjct: 1383 LYSCRAENQAGTAQRDF 1399
Score = 77.8 bits (190), Expect = 3e-14
Identities = 75/270 (27%), Positives = 112/270 (41%), Gaps = 45/270 (16%)
Query: 28 GEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLN--GGTLTIPAITSDDAGTYSCIANN 85
G+ + L C G P P + W + + E G TL A++ +D+GTY C A N
Sbjct: 4143 GDRLWLRCAARGS-PTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAEN 4201
Query: 86 NVGNPAKKSTNIIVRA--LKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFS 143
VG S + A L+ F +P +G +++ C V P ++
Sbjct: 4202 RVGRTQAVSFVHVKEAPVLQGEAFSYLVEP--------VGGSIQLDCVVRGDPVPDI--H 4251
Query: 144 WFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISID 203
W K+G PLR S Q +L I + D G Y C+A + G + I
Sbjct: 4252 WIKDGLPLRGSHLRHQLQNG--------SLTIHRTERDDAGRYQCLAENEMGVAKKVVIL 4303
Query: 204 VNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEV-------A 256
V S+ P PQ+ + R GD + L+CQ TG+P P I W +A + +
Sbjct: 4304 VLQSA---PVFQVEPQD---MTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRT 4357
Query: 257 MPDGSMQMESYDGTLRIVNVSREMSGMYRC 286
+PDGS+ +E NV +G Y C
Sbjct: 4358 LPDGSLWLE---------NVETGDAGTYDC 4378
Score = 77.4 bits (189), Expect = 4e-14
Identities = 76/332 (22%), Positives = 137/332 (41%), Gaps = 35/332 (10%)
Query: 14 SIKLLVDDPIVVNP-------GEAITLVCVTTGGEPAPSLTWVRSFGTLPE----KTVLN 62
++K+LV I P ++TL C+ +G P P ++W + + ++
Sbjct: 1879 ALKVLVPPNIEPGPVNKAVLENASVTLECLASG-VPPPDVSWFKGHQPVSSWMGVTVSVD 1937
Query: 63 GGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQI 122
G L I DAG+Y C+A+N G+ + +R R + P + +
Sbjct: 1938 GRVLRIEQAQLSDAGSYRCVASNVAGSTELRYG---LRVNVPPRITLPPS---LPGPVLV 1991
Query: 123 GREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTD 182
V+++C PS T W K+G P+ + + V PG L + + +D
Sbjct: 1992 NTPVRLTCNATGAPSP--TLMWLKDGNPVSPAGTPGL-----QVFPGGRVLTLASARASD 2044
Query: 183 FGTYTCVA-SLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGK 241
G Y+CVA S G D+ + V+ +PP++ + +V E ++ L+CQ
Sbjct: 2045 SGRYSCVAVSAVGEDRQDVVLQVH-----MPPSILGEELNVSVVANE--SVALECQSHAM 2097
Query: 242 PKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREA 301
P P++ W + D P + + + L++ +G Y C+ G + K
Sbjct: 2098 PPPVLSWWK-DGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNL 2156
Query: 302 LVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCR 333
V + + P E L +R+G S++ CR
Sbjct: 2157 NVWVAPVF-PLRESHTLTVREGHPTSLSCECR 2187
Score = 75.1 bits (183), Expect = 2e-13
Identities = 93/379 (24%), Positives = 152/379 (40%), Gaps = 42/379 (11%)
Query: 24 VVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLN----GGTLTIPAITSDDAGTY 79
VV G A TL C TG +P P++TW R + + L G +L + + G Y
Sbjct: 2270 VVQDGVA-TLECNATG-KPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRY 2327
Query: 80 SCIANNNVGNPAKK-STNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSE 138
SC+A N G +K +++V G DP NI ++ EA+
Sbjct: 2328 SCVAENLAGRAERKFELSVLVPPELIGDL----DPL---TNITAALHSPLTLLCEAMGIP 2380
Query: 139 ELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGIS 198
WF+ P+ E D + G L + + D G Y+C+AS + G
Sbjct: 2381 PPAIRWFRGEEPVSPGE-------DTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEAR 2433
Query: 199 -DISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAM 257
+ S++V VPP++ + + +G T L C VTG P+P + W + + +A
Sbjct: 2434 RNFSVEV-----LVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLAR 2488
Query: 258 PDGSMQMESYDGT-LRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAV--- 313
G S DG L+++ + +G Y C + G K QL V P +
Sbjct: 2489 --GDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKH----FQLSVLLAPTILGG 2542
Query: 314 --EPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTE-YAVK 370
+ A E+ + +++ C L A+P +T+ + G + T +
Sbjct: 2543 AEDSADEEVTVTVNNPISLICEAL-AFPSPNITW-MKDGAPFEASRNIQLLPGTHGLQIL 2600
Query: 371 SLSNENYGVYNCSIINEAG 389
+ E+ G Y C + NE G
Sbjct: 2601 NAQKEDAGQYTCVVTNELG 2619
Score = 74.7 bits (182), Expect = 3e-13
Identities = 94/385 (24%), Positives = 156/385 (40%), Gaps = 63/385 (16%)
Query: 28 GEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLNGG----------TLTIPAITSDDAG 77
G + L C T+G P P + W + + VL GG L I D G
Sbjct: 1423 GADVELQCWTSG-VPTPQVEWTKD-----RQPVLPGGPHLQVQEDGQVLRITGSHVGDEG 1476
Query: 78 TYSCIANNNVGNPAKKSTNIIVRALKKGRFW---ITPDPYHKDDNIQIGREVKISCQVEA 134
Y C+A + G A+ + +R W T + +D++ V++ C+
Sbjct: 1477 RYQCVAFSPAGQQAR---DFQLRVHAPPTIWGSNETGEVAVMEDHL-----VQLLCEARG 1528
Query: 135 VPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKG 194
VP+ +T WFK+G L +S ++V T+ G L + + +D G YTC AS
Sbjct: 1529 VPTPNIT--WFKDGALLPTSTKVVYTR-------GGRQLQLGRAQSSDAGVYTCKASNAV 1579
Query: 195 GGISDIS-IDVNISSSTVPPNLTVPQEKSPLVTR--EGDTIELQCQVTGKPKPIILWSRA 251
G + +DV VPP + + P V + G + L+C G P P + W
Sbjct: 1580 GAAEKATRLDV-----YVPPTIEGAGGR-PYVVKAVAGRPVALECVARGHPSPTLSWHHE 1633
Query: 252 DKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPP 311
VA + S ++E+ LR+ + SG+Y C S G + ++QY
Sbjct: 1634 GLPVAESNES-RLETDGSVLRLESPGEASSGLYSCVASSPAG----------EAVLQYSV 1682
Query: 312 AVE-PAFLEIRQGQDRSVTMSCRVL----RAYPIRVLTYEWRLGNKLLR--TGQFDSQEY 364
V+ P L + +G + T+ + L +A V T +W + G + +
Sbjct: 1683 EVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQG 1742
Query: 365 TEYAVKSLSNENYGVYNCSIINEAG 389
T + + ++ G++ C NEAG
Sbjct: 1743 TTLHIDHVELDHSGLFACQATNEAG 1767
Score = 72.8 bits (177), Expect = 1e-12
Identities = 76/315 (24%), Positives = 124/315 (39%), Gaps = 32/315 (10%)
Query: 75 DAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEA 134
+ GTY C A + G K+ ++ + + P P + + G +SC+V
Sbjct: 490 EEGTYECTAVSRAGTGRAKAQIVVTDPPPQ----LVPAP---NVTVSPGETAVLSCRVLG 542
Query: 135 VPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKG 194
LT W ++ R L +S V D +L+I + TD G Y CVAS
Sbjct: 543 EAPYNLT--WVRDWRVLPASTGRVAQLAD-------LSLEISGIIPTDGGRYQCVAS-NA 592
Query: 195 GGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKE 254
G++ S+ + + + T Q S +G +++ C +G P P I WSR + +
Sbjct: 593 NGVTRASVWLLVREAPQVSIHTSSQHFS-----QGVEVKVSCSASGYPTPHISWSR-ESQ 646
Query: 255 VAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVE 314
D + +++ GTL I V+ E +G Y CQ + G + + V L PP+V
Sbjct: 647 ALQEDSRIHVDA-QGTLIIQGVAPEDAGNYSCQATNEVGTD----QETVTLYYTDPPSVS 701
Query: 315 PAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAVKSLSN 374
+ + C P RV+ Y L L G + + +
Sbjct: 702 AVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSG----KLRIPAAQE 757
Query: 375 ENYGVYNCSIINEAG 389
+ G Y C +NE G
Sbjct: 758 RDAGTYTCRAVNELG 772
Score = 71.6 bits (174), Expect = 2e-12
Identities = 88/348 (25%), Positives = 142/348 (40%), Gaps = 57/348 (16%)
Query: 20 DDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLP--EKTVLNGGT--LTIPAITSDD 75
D+ + V I+L+C P+P++TW++ L GT L I +D
Sbjct: 2548 DEEVTVTVNNPISLICEALAF-PSPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKED 2606
Query: 76 AGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNI-QIG-REVK------ 127
AG Y+C+ N +G K N V L P KDD + ++G +EVK
Sbjct: 2607 AGQYTCVVTNELGEAVK---NYHVEVL-------IPPSISKDDPLGEVGVKEVKTKVNST 2656
Query: 128 --ISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGT 185
+ C+ AVP T W+K+G+P+ S R+ + + G L I + +D G
Sbjct: 2657 LTLECESWAVPPP--TIRWYKDGQPVTPSSRLQV------LGEGRL-LQIQPTQVSDSGR 2707
Query: 186 YTCVA-SLKGGGISDISIDVNI--------SSSTVPPNLTVPQEKSPLVTREGDTIE--- 233
Y CVA ++ G D ++ + + S L+ +E VT + +E
Sbjct: 2708 YLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNP 2767
Query: 234 --LQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQY 291
L C P P + W R D+ ++ D ++ L+I V E +G Y C+ S
Sbjct: 2768 AYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQG-GRVLQIPLVRAENAGRYSCKASNE 2826
Query: 292 NGFNVKPREALVQLIVQYPPAV----EPAFLEIRQGQDRSVTMSCRVL 335
G + E L+V PP + E E+ +V++ C L
Sbjct: 2827 VGEDWLHYE----LLVLTPPVILGDTEELVEEVTVNASSTVSLQCPAL 2870
Score = 67.8 bits (164), Expect = 3e-11
Identities = 92/390 (23%), Positives = 148/390 (37%), Gaps = 54/390 (13%)
Query: 27 PGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLN----GGTLTIPAITSDDAGTYSCI 82
PG+ + L C + EPAP +TW R L E G L + A+++ D+G YSC
Sbjct: 3596 PGQLV-LEC-SVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCT 3653
Query: 83 ANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTF 142
A N G ST++ R I P N+ + + + CQ + VP+ +
Sbjct: 3654 ARNAAG-----STSVAFRVEIHTVPTIRSGP--PAVNVSVNQTALLPCQADGVPAPLV-- 3704
Query: 143 SWFKNGRPL--RSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGIS-- 198
SW K+ PL RS ++ + + P D G Y C+AS G
Sbjct: 3705 SWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQ---------DAGHYLCLASNSAGSDRQG 3755
Query: 199 -DISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAM 257
D+ + + + P NLT+ L L C+ +G PKP+++W + +++
Sbjct: 3756 RDLRVLEPPAIAPSPSNLTLTAHTPAL---------LPCEASGSPKPLVVWWKDGQKL-- 3804
Query: 258 PDGSMQMESY----DGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAV 313
D +Q +Y L + + S + C S V L Q+ V PP +
Sbjct: 3805 -DFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSN----EVGEAHRLYQVTVHVPPTI 3859
Query: 314 EPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEW-RLGNKL-LRTGQFDSQEYTEYAVKS 371
+ V ++C + I T W + G +L R + +
Sbjct: 3860 ADDQTDFTVTMMAPVVLTC---HSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQ 3916
Query: 372 LSNENYGVYNCSIINEAGAGRCSFLVTGKA 401
+ G Y CS N AG +T +A
Sbjct: 3917 ALPIHAGRYTCSARNSAGVAHKHVFLTVQA 3946
Score = 66.2 bits (160), Expect = 1e-10
Identities = 71/309 (22%), Positives = 121/309 (39%), Gaps = 56/309 (18%)
Query: 28 GEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLNG----GTLTIPAITSDDAGTYSCIA 83
GEA+ L CV G P P L+W + + VL G G++ AI + DAG Y C A
Sbjct: 1134 GEALDLNCVAEGN-PEPQLSWSK------DGVVLQGRGPQGSVHFAAIRTSDAGRYRCEA 1186
Query: 84 NNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQI-----GREVKISCQVEAVPSE 138
+N+ G A + + +R L+ P + D+ + G + C P
Sbjct: 1187 SNSAGVDAWE---VELRVLE-------PPHWGADETSGLLERVAGENASLPCPARGTPKP 1236
Query: 139 ELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGIS 198
++T+ + PL + + + +L + + D G Y C A+ + G S
Sbjct: 1237 QVTWRKGPSSEPLHGQPGVAVLEEG--------SLFLASVSPADSGDYECQATNEVGSTS 1288
Query: 199 DISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMP 258
+ V VPP++ K+ + G ++ L+C G P P I+W + + V +P
Sbjct: 1289 RRAKLVVY----VPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVP 1344
Query: 259 --------------DGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQ 304
G ++ +L + SG+Y C+ G +
Sbjct: 1345 LGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAG----TAQRDFH 1400
Query: 305 LIVQYPPAV 313
L+V PP+V
Sbjct: 1401 LLVLTPPSV 1409
Score = 65.5 bits (158), Expect = 2e-10
Identities = 89/386 (23%), Positives = 146/386 (37%), Gaps = 48/386 (12%)
Query: 28 GEAITLVCVTTGGEPAPSLTWVRSFGT-----LPEKTVLNGGTLTIPAITSDDAGTYSCI 82
GE +L C G P P +TW + + P VL G+L + +++ D+G Y C
Sbjct: 1221 GENASLPCPARG-TPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQ 1279
Query: 83 ANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTF 142
A N VG+ ++++ ++ I D + + G+ + + C P E+ +
Sbjct: 1280 ATNEVGSTSRRAKLVVYVPPS-----IREDGRKANVSGMAGQSLTLECDANGFPVPEIVW 1334
Query: 143 -----------SWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVAS 191
W G L + D S L ++ D G Y+C A
Sbjct: 1335 LKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQS-----LHFPRIQEGDSGLYSCRAE 1389
Query: 192 LKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRA 251
+ G D ++ T PP++ ++ G +ELQC +G P P + W++
Sbjct: 1390 NQAGTAQR---DFHLLVLT-PPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTK- 1444
Query: 252 DKEVAMPDG-SMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYP 310
D++ +P G +Q++ LRI G Y+C G + QL V P
Sbjct: 1445 DRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARD----FQLRVHAP 1500
Query: 311 PAV--EPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYT--- 365
P + E+ +D V + C R P +T W LL T YT
Sbjct: 1501 PTIWGSNETGEVAVMEDHLVQLLCEA-RGVPTPNIT--WFKDGALLPTS--TKVVYTRGG 1555
Query: 366 -EYAVKSLSNENYGVYNCSIINEAGA 390
+ + + + GVY C N GA
Sbjct: 1556 RQLQLGRAQSSDAGVYTCKASNAVGA 1581
Score = 64.7 bits (156), Expect = 3e-10
Identities = 92/398 (23%), Positives = 156/398 (39%), Gaps = 47/398 (11%)
Query: 13 PSIKLLVDDPIVVNP--GEAITLVCVTTGGEPAPSLTWVRSFGTLPE----KTVLNGGTL 66
P+I+ P VV G + L CV G P+P+L+W + E + +G L
Sbjct: 1594 PTIEGAGGRPYVVKAVAGRPVALECVARG-HPSPTLSWHHEGLPVAESNESRLETDGSVL 1652
Query: 67 TIPAITSDDAGTYSCIANNNVGNPAKK-STNIIVRA---LKKGRFWITPDPYHKDDNIQI 122
+ + +G YSC+A++ G + S + V + +G +T +
Sbjct: 1653 RLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTI---------V 1703
Query: 123 GREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTD 182
G+ +++ CQ P T W +NGRP +E + Q S GTT L I ++
Sbjct: 1704 GQPLELPCQASGSPVP--TIQWLQNGRP---AEELAGVQV---ASQGTT-LHIDHVELDH 1754
Query: 183 FGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVT--- 239
G + C A+ + G + ++V++ P L VP + + C
Sbjct: 1755 SGLFACQATNEAG-TAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHR 1813
Query: 240 ---GKPKPIIL--WSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGF 294
PKP ++ W P G S L+I V G+Y C + G
Sbjct: 1814 GWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGE 1873
Query: 295 NVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLL 354
+ RE ++++V PP +EP + ++ SVT+ C P V W G++ +
Sbjct: 1874 S--KREVALKVLV--PPNIEPGPVNKAVLENASVTLECLASGVPPPDV---SWFKGHQPV 1926
Query: 355 RT--GQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGA 390
+ G S + ++ + G Y C N AG+
Sbjct: 1927 SSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGS 1964
Score = 62.0 bits (149), Expect = 2e-09
Identities = 72/289 (24%), Positives = 110/289 (38%), Gaps = 44/289 (15%)
Query: 23 IVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTL----------PEKTVLNGGTLTIPAIT 72
+ V G + L C TG P P++TW R G + G L ++
Sbjct: 795 VTVELGRSALLACRATG-RPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVA 853
Query: 73 SDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQI--GREVKISC 130
+D Y C A N G ++ I+ P +++ G+ V + C
Sbjct: 854 PEDQAPYVCEARNVFGKVQAEARLIVTGHAP-------PQIASSAPTVRVLEGQPVSLPC 906
Query: 131 QVEA---VPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYT 187
V A +P W K+GRPL R I + G+ +LD + G Y+
Sbjct: 907 IVLAGRPLPERH----WLKDGRPLPPGSRHSIR------ADGSLHLDRALQEHA--GRYS 954
Query: 188 CVASLKGGGIS-DISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPII 246
CVA+ G D+ + V VPP + + +T EG L C +G P P I
Sbjct: 955 CVATNTAGSQHRDVELVVQ-----VPPR--IHPTATHHITNEGVPASLPCVASGVPAPTI 1007
Query: 247 LWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFN 295
W++ + G S +GTL I S + +G Y C + GF+
Sbjct: 1008 TWTK-ETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFS 1055
Score = 54.7 bits (130), Expect = 3e-07
Identities = 87/381 (22%), Positives = 140/381 (36%), Gaps = 43/381 (11%)
Query: 15 IKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLNGGTLTI----PA 70
I L+++ + PG ++ + G+P TLP K + NG T + P
Sbjct: 341 ISLVINSTGLKAPGRLDSVELAQSSGKPLL---------TLPTKPLSNGSTHQLWGGPPF 391
Query: 71 ITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISC 130
T + ++ GNP + + + + G ++ P + + + +SC
Sbjct: 392 HTPKERFYLKVKGKDHEGNPLLRVSGVSYSGVAPGAPLVSMAPRIHG---YLHQPLLVSC 448
Query: 131 QVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVA 190
V + L + G ER G ++ +I+ + GTY C A
Sbjct: 449 SVHSALPFRLQL---RRGEARLGEERHF-------QESGNSSWEILRASKAEEGTYECTA 498
Query: 191 -SLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVT-REGDTIELQCQVTGKPKPIILW 248
S G G + I V T PP VP +P VT G+T L C+V G+ + W
Sbjct: 499 VSRAGTGRAKAQIVV-----TDPPPQLVP---APNVTVSPGETAVLSCRVLGEAPYNLTW 550
Query: 249 SRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQ 308
R D V + D +L I + G Y+C S NG A V L+V+
Sbjct: 551 VR-DWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVT----RASVWLLVR 605
Query: 309 YPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYA 368
P V Q V +SC YP +++ R L +
Sbjct: 606 EAPQVSIHTSSQHFSQGVEVKVSCSA-SGYPTPHISWS-RESQALQEDSRIHVDAQGTLI 663
Query: 369 VKSLSNENYGVYNCSIINEAG 389
++ ++ E+ G Y+C NE G
Sbjct: 664 IQGVAPEDAGNYSCQATNEVG 684
Score = 45.4 bits (106), Expect = 2e-04
Identities = 26/86 (30%), Positives = 47/86 (54%), Gaps = 5/86 (5%)
Query: 23 IVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKT---VLNGGTLTIPAITSDDAGTY 79
+ V G+ + L C TG EP P++ W+++ L L G+L + + + DAGTY
Sbjct: 4318 MTVRSGDDVALRCQATG-EPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTY 4376
Query: 80 SCIANNNVGNPAKKSTNIIVRALKKG 105
C+A+N +G+ ++ ++VR +G
Sbjct: 4377 DCVAHNLLGSATARAF-LVVRGEPQG 4401
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 95.1 bits (235), Expect = 2e-19
Identities = 95/384 (24%), Positives = 169/384 (44%), Gaps = 46/384 (11%)
Query: 28 GEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTV----LNGGTLTIPAITSDDAGTYSCIA 83
G + L C G PAP++TW++ + V GG L + + AGTY+C+A
Sbjct: 1857 GSPLVLTC-DVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVA 1915
Query: 84 NNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFS 143
N A+ + +V L R I ++ ++ G+EV++ C+ + P ++ +
Sbjct: 1916 EN---TQAEARKDFVVAVLVAPR--IRSSGVAREHHVLEGQEVRLDCEADGQPPPDV--A 1968
Query: 144 WFKNGRPLRSSERMVITQTDPDVSPGTT------NLDIIDLKFTDFGTYTCVASLKGGGI 197
W K+G PL D+ P +L + L+ +D G YTCVA G
Sbjct: 1969 WLKDGSPL-----------GQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGED 2017
Query: 198 SDISIDVNISSSTVPPNLTVPQEKS-PLVTREGDTIELQCQVTGKPKPIILWSRADKEVA 256
+ + VN+ VPP + + S LV+R G+ + + C V G P + W + +
Sbjct: 2018 ARLH-TVNV---LVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLP 2073
Query: 257 MPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPA 316
+ ++ + TLRI V +G++ C + G V R +Q VQ PP +EP
Sbjct: 2074 LSQRTL-LHGSGHTLRISKVQLADAGIFTCVAASPAG--VADRNFTLQ--VQVPPVLEPV 2128
Query: 317 FL--EIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAVKSLSN 374
++ + V + C R P+ ++++ + G LL ++ ++++
Sbjct: 2129 EFQNDVVVVRGSLVELPCEA-RGVPLPLVSW-MKDGEPLLSQ---SLEQGPSLQLEAVGA 2183
Query: 375 ENYGVYNCSIINEAGAGRCSFLVT 398
+ G Y+C ++EAG R F +T
Sbjct: 2184 GDSGTYSCVAVSEAGEARRHFQLT 2207
Score = 94.0 bits (232), Expect = 4e-19
Identities = 94/319 (29%), Positives = 135/319 (42%), Gaps = 55/319 (17%)
Query: 23 IVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVL----NGGTLTIPAITSDDAGT 78
+ V + L+C G P P++TW + LP T + G L + S DAG
Sbjct: 230 VAVMEDHLVQLLCEARG-VPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGV 288
Query: 79 YSCIANNNVGNPAKKSTNIIVRALKK-----GRFWITPDPYHKDDNIQIGREVKISCQVE 133
Y+C A+N VG A+K+T + V GR ++ GR V + C
Sbjct: 289 YTCKASNAVG-AAEKATRLDVYVPPTIEGAGGRPYVV--------KAVAGRPVALECVAR 339
Query: 134 AVPSEELTFSWFKNGRPLRSSERMVITQTDPDV----SPGTTNLDIIDLKFTDFGTYTCV 189
PS T SW G P+ S + +TD V SPG + G Y+CV
Sbjct: 340 GHPSP--TLSWHHEGLPVAESNESRL-ETDGSVLRLESPGEASS----------GLYSCV 386
Query: 190 ASLKGG-GISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILW 248
AS G + S++V VPP L V + + T G +EL CQ +G P P I W
Sbjct: 387 ASSPAGEAVLQYSVEVQ-----VPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQW 441
Query: 249 ---SRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQL 305
R +E+A +Q+ S TL I +V + SG++ CQ + N E V +
Sbjct: 442 LQNGRPAEELA----GVQVASQGTTLHIDHVELDHSGLFACQAT--NEAGTAGAEVEVSV 495
Query: 306 IVQYPPAVEPAFLEIRQGQ 324
++ P V LE+ GQ
Sbjct: 496 HGEWAPGV----LEVPIGQ 510
Score = 93.6 bits (231), Expect = 6e-19
Identities = 103/389 (26%), Positives = 162/389 (41%), Gaps = 57/389 (14%)
Query: 28 GEAITLVCVTTGGEPAPSLTWVRSFGTLPE------KTVLNGGTLTIPAITSDDAGTYSC 81
G+ + L C G+P P + W++ L + + L+GG+L + + + DAG Y+C
Sbjct: 1950 GQEVRLDC-EADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTC 2008
Query: 82 IANNNVGNPAKKST-NIIVRALKK----GRFWITPDPYHKDDNIQIGREVKISCQVEAVP 136
+A+N G A+ T N++V K G + P G V + C V P
Sbjct: 2009 VAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRP---------GELVTMVCPVRGSP 2059
Query: 137 SEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGG 196
+ SW K+G PL S+R ++ G T L I ++ D G +TCVA+ G
Sbjct: 2060 --PIHVSWLKDGLPLPLSQRTLLH------GSGHT-LRISKVQLADAGIFTCVAA-SPAG 2109
Query: 197 ISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVA 256
++D + + + VPP L + ++ +V G +EL C+ G P P++ W + D E
Sbjct: 2110 VADRNFTLQVQ---VPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMK-DGEPL 2165
Query: 257 MPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVE-- 314
+ Q S L++ V SG Y C G QL V PP +E
Sbjct: 2166 LSQSLEQGPS----LQLEAVGAGDSGTYSCVAVSEAG----EARRHFQLTVMEPPHIEDS 2217
Query: 315 --PAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAVKSL 372
P L + G + + P +T+ + G L R E A + L
Sbjct: 2218 GQPTELSLTPGAPMELLCDA---QGTPQPNITWH-KDGQALTRL------ENNSRATRVL 2267
Query: 373 SNENYGVYNCSIINEAGAGRCSFLVTGKA 401
+ G+Y C + AGA SF V +A
Sbjct: 2268 RVRDAGLYTCLAESPAGAIEKSFRVRVQA 2296
Score = 93.6 bits (231), Expect = 6e-19
Identities = 105/392 (26%), Positives = 168/392 (42%), Gaps = 49/392 (12%)
Query: 11 ASPSIKLLVDDPIVVNP--GEAITLVCVTTGGEPAPSLTWVR---SFGTLPEKTVLNGGT 65
ASP +K L P VV E + L C +G P P++TW + + T VL GG
Sbjct: 2664 ASPVVKPL---PSVVRAVAEEEVLLPCEASG-IPRPTITWQKEGLNVATGVSTQVLPGGQ 2719
Query: 66 LTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVR---ALKKGRFWITPDPYHKDDNIQI 122
L I + +DAG Y CIA N+ G+ A T ++V+ ++ G D +
Sbjct: 2720 LRIAHASPEDAGNYLCIAKNSAGS-AMGKTRLVVQVPPVIENGL---------PDLSTTE 2769
Query: 123 GREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTD 182
G + C+ P +T W K+G+P+ +E Q + L + +L+ D
Sbjct: 2770 GSHAFLPCKARGSPEPNIT--WDKDGQPVSGAEGKFTIQPSGE-------LLVKNLEGQD 2820
Query: 183 FGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKP 242
GTYTC A + V+++ +P T+P ++S R GD + L+C G P
Sbjct: 2821 AGTYTCTAE---NAVGRARRRVHLTILVLPVFTTLPGDRS---LRLGDRLWLRCAARGSP 2874
Query: 243 KPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREAL 302
P I W+ D+ V +G + + TL+ VSRE SG Y C V +A+
Sbjct: 2875 TPRIGWTVNDRPVT--EGVSEQDG-GSTLQRAAVSREDSGTYVCWAEN----RVGRTQAV 2927
Query: 303 VQLIVQYPPAVE-PAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDS 361
+ V+ P ++ AF + + S+ + C V+R P+ + W LR
Sbjct: 2928 SFVHVKEAPVLQGEAFSYLVEPVGGSIQLDC-VVRGDPVPDI--HWIKDGLPLRGSHLRH 2984
Query: 362 Q-EYTEYAVKSLSNENYGVYNCSIINEAGAGR 392
Q + ++ ++ G Y C NE G +
Sbjct: 2985 QLQNGSLTIRRTERDDAGRYQCLAENEMGVAK 3016
Score = 87.0 bits (214), Expect = 5e-17
Identities = 98/375 (26%), Positives = 160/375 (42%), Gaps = 43/375 (11%)
Query: 38 TGGEPAPSLTWVRSFGTLP---EKTVLNGG-TLTIPAITSDDAGTYSCIANNNVGNPAKK 93
T P P LTW R L E +VL GG L IP + +++AG YSC A+N VG
Sbjct: 1492 TNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLH 1551
Query: 94 STNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRS 153
+++ I D + + + +S Q A+ + T SW +NG P
Sbjct: 1552 YELLVLTPPV-----ILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSP 1606
Query: 154 SERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDI-SIDVNISSSTVP 212
S R+ + + D V L + + D +Y CVA + G + ++ V VP
Sbjct: 1607 SPRLQVLE-DGQV------LQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQ-----VP 1654
Query: 213 PNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLR 272
P + + + ++ L C V P P + W + + +++ + + TL+
Sbjct: 1655 PRI-AGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPG-THTLQ 1712
Query: 273 IVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPA------FLEIRQGQDR 326
+ SGMY C+ G + K LVQL V PPA A + +R G D+
Sbjct: 1713 LGRARLSDSGMYTCEALNAAGRDQK----LVQLSVLVPPAFRQAPRGPQDAVLVRVG-DK 1767
Query: 327 SVTMSCRVLRAYPIRVLTYEWRLGNKLL---RTGQFDSQEYTEYAVKSLSNENYGVYNCS 383
+V +SC A P +T+ ++ G L+ RT + E +S++ G+Y+C
Sbjct: 1768 AV-LSCET-DALPEPTVTW-YKDGQPLVLAQRTQALRGGQRLEIQEAQVSDK--GLYSCK 1822
Query: 384 IINEAGAGRCSFLVT 398
+ N AG +F +T
Sbjct: 1823 VSNVAGEAVRTFTLT 1837
Score = 85.9 bits (211), Expect = 1e-16
Identities = 103/394 (26%), Positives = 163/394 (41%), Gaps = 59/394 (14%)
Query: 22 PIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTL-----PEKTVLNGG-TLTIPAITSDD 75
P++VN + L C TG P+P+L W++ + P V GG LT+ + + D
Sbjct: 706 PVLVNT--PVRLTCNATGA-PSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASD 762
Query: 76 AGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQI--GREVKISCQVE 133
+G YSC+A + VG + +++++ + P ++ N+ + V + CQ
Sbjct: 763 SGRYSCVAVSAVGEDRQ---DVVLQV------HMPPSILGEELNVSVVANESVALECQSH 813
Query: 134 AVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLK 193
A+P L SW+K+GRPL + +S L + D G YTC A L
Sbjct: 814 AMPPPVL--SWWKDGRPLEPRPGV-------HLSADKALLQVDRADVWDAGHYTCEA-LN 863
Query: 194 GGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADK 253
G S+ ++N+ + V P +E L REG L C+ G P P I W + +
Sbjct: 864 QAGHSEKHYNLNVWVAPVFPL----RESHTLTVREGHPTRLSCECRGVPFPKISWRKDGQ 919
Query: 254 EVAMPDGSMQMESYDGTLRIVNVSR-EMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPA 312
+ +Q S G L + ++ G Y C+ S G + + +QL V PP
Sbjct: 920 PLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQD----LQLEVHVPPQ 975
Query: 313 V----EPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYE-------WRLGNKLLRTGQFDS 361
+ EP ++ QD T+ C P +T+E LG +L GQ
Sbjct: 976 IAGPREPP-TQVSVVQDGVATLECNA-TGKPPPTVTWERDGQPVGAELGLQLQNQGQSLH 1033
Query: 362 QEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSF 395
E + A + G Y+C N AG F
Sbjct: 1034 VERAQAA-------HTGRYSCVAENLAGRAERKF 1060
Score = 85.5 bits (210), Expect = 2e-16
Identities = 95/390 (24%), Positives = 160/390 (41%), Gaps = 46/390 (11%)
Query: 23 IVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLN----GGTLTIPAITSDDAGT 78
+ V E++ L C + P P L+W + L + ++ L + DAG
Sbjct: 798 VSVVANESVALEC-QSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGH 856
Query: 79 YSCIANNNVGNPAKKSTNIIVRALKKGRFWITPD-PYHKDDNIQI--GREVKISCQVEAV 135
Y+C A N G+ ++K N+ V W+ P P + + + G ++SC+ V
Sbjct: 857 YTCEALNQAGH-SEKHYNLNV--------WVAPVFPLRESHTLTVREGHPTRLSCECRGV 907
Query: 136 PSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVAS-LKG 194
P ++ SW K+G+PL + VS L + + GTYTC S + G
Sbjct: 908 PFPKI--SWRKDGQPLPGEGAGL-----QHVSAVGRLLYLGQAQLAQEGTYTCECSNVVG 960
Query: 195 GGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIE-LQCQVTGKPKPIILWSRADK 253
D+ ++V+ VPP + P+E V+ D + L+C TGKP P + W R +
Sbjct: 961 NSSQDLQLEVH-----VPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQ 1015
Query: 254 EVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAV 313
V G +Q+++ +L + +G Y C G E +L V PP +
Sbjct: 1016 PVGAELG-LQLQNQGQSLHVERAQAAHTGRYSCVAENLAG----RAERKFELSVLVPPEL 1070
Query: 314 ----EPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAV 369
+P I +T+ C + P + W G + + G+ + +
Sbjct: 1071 IGDLDP-LTNITAALHSPLTLLCEAMGIPPPAI---RWFRGEEPVSPGEDTYLLAGGWML 1126
Query: 370 K--SLSNENYGVYNCSIINEAGAGRCSFLV 397
K ++ G+Y+C NEAG R +F V
Sbjct: 1127 KMTQTQEQDSGLYSCLASNEAGEARRNFSV 1156
Score = 83.6 bits (205), Expect = 6e-16
Identities = 102/402 (25%), Positives = 173/402 (43%), Gaps = 52/402 (12%)
Query: 8 NKTASPSIKLLVDDP--IVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLP--EKTVLNG 63
N P+IK D +V PGE +T+VC G P ++W++ LP ++T+L+G
Sbjct: 2024 NVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPI-HVSWLKDGLPLPLSQRTLLHG 2082
Query: 64 G--TLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQ 121
TL I + DAG ++C+A + G A ++ + V+ + P + D +
Sbjct: 2083 SGHTLRISKVQLADAGIFTCVAASPAG-VADRNFTLQVQVPPV----LEPVEFQNDVVVV 2137
Query: 122 IGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFT 181
G V++ C+ VP SW K+G PL S + P +L + +
Sbjct: 2138 RGSLVELPCEARGVPLP--LVSWMKDGEPLLSQS----LEQGP-------SLQLEAVGAG 2184
Query: 182 DFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGK 241
D GTY+CVA + G + + + PP++ + + L G +EL C G
Sbjct: 2185 DSGTYSCVA-VSEAGEARRHFQLTVME---PPHIEDSGQPTELSLTPGAPMELLCDAQGT 2240
Query: 242 PKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREA 301
P+P I W + + + ++E+ R++ V +G+Y C G E
Sbjct: 2241 PQPNITWHKDGQALT------RLENNSRATRVLRV--RDAGLYTCLAESPAG----AIEK 2288
Query: 302 LVQLIVQYPPAV----EPAF-LEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRT 356
++ VQ PP + P F + + GQ + + C V A P +T+ R G L
Sbjct: 2289 SFRVRVQAPPNIVGPRGPRFVVGLAPGQ---LVLECSV-EAEPAPKITWH-RDGIVLQED 2343
Query: 357 GQFDSQEYTEY-AVKSLSNENYGVYNCSIINEAGAGRCSFLV 397
E + +++LS + G Y+C+ N AG+ +F V
Sbjct: 2344 AHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRV 2385
Score = 82.0 bits (201), Expect = 2e-15
Identities = 93/384 (24%), Positives = 156/384 (40%), Gaps = 60/384 (15%)
Query: 23 IVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLNGGTLTIPAITSDDAGTYSCI 82
+VV G + L C G P P ++W++ L +++ G +L + A+ + D+GTYSC+
Sbjct: 2134 VVVVRGSLVELPCEARG-VPLPLVSWMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCV 2192
Query: 83 ANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDD-------NIQIGREVKISCQVEAV 135
A + G A++ + V +P H +D ++ G +++ C +
Sbjct: 2193 AVSEAGE-ARRHFQLTVM-----------EPPHIEDSGQPTELSLTPGAPMELLCDAQGT 2240
Query: 136 PSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGG 195
P +T W K+G+ L E + T + L+ D G YTC+A G
Sbjct: 2241 PQPNIT--WHKDGQALTRLEN----------NSRATRV----LRVRDAGLYTCLAESPAG 2284
Query: 196 GISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEV 255
I + S V + + PPN+ P+ +V + L+C V +P P I W R D V
Sbjct: 2285 AI-EKSFRVRVQA---PPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHR-DGIV 2339
Query: 256 AMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNG-----FNVKPREALVQLIVQYP 310
D Q L++ +S SG Y C G F V+ V I P
Sbjct: 2340 LQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIH--TVPTIRSGP 2397
Query: 311 PAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLL--RTGQFDSQEYTEYA 368
PAV + +++ + C +A + WR L R+ +F+
Sbjct: 2398 PAVNVSV-------NQTALLPC---QADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLR 2447
Query: 369 VKSLSNENYGVYNCSIINEAGAGR 392
++ + ++ G Y C N AG+ R
Sbjct: 2448 IQPVLAQDAGHYLCLASNSAGSDR 2471
Score = 77.8 bits (190), Expect = 3e-14
Identities = 75/270 (27%), Positives = 112/270 (41%), Gaps = 45/270 (16%)
Query: 28 GEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLN--GGTLTIPAITSDDAGTYSCIANN 85
G+ + L C G P P + W + + E G TL A++ +D+GTY C A N
Sbjct: 2861 GDRLWLRCAARGS-PTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAEN 2919
Query: 86 NVGNPAKKSTNIIVRA--LKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFS 143
VG S + A L+ F +P +G +++ C V P ++
Sbjct: 2920 RVGRTQAVSFVHVKEAPVLQGEAFSYLVEP--------VGGSIQLDCVVRGDPVPDI--H 2969
Query: 144 WFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISID 203
W K+G PLR S Q +L I + D G Y C+A + G + I
Sbjct: 2970 WIKDGLPLRGSHLRHQLQNG--------SLTIRRTERDDAGRYQCLAENEMGVAKKVVIL 3021
Query: 204 VNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEV-------A 256
V S+ P PQ+ + R GD + L+CQ TG+P P I W +A + +
Sbjct: 3022 VLQSA---PVFQVEPQD---MTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRT 3075
Query: 257 MPDGSMQMESYDGTLRIVNVSREMSGMYRC 286
+PDGS+ +E NV +G Y C
Sbjct: 3076 LPDGSLWLE---------NVETGDAGTYDC 3096
Score = 75.5 bits (184), Expect = 2e-13
Identities = 75/332 (22%), Positives = 136/332 (40%), Gaps = 35/332 (10%)
Query: 14 SIKLLVDDPIVVNP-------GEAITLVCVTTGGEPAPSLTWVRSFGTLPE----KTVLN 62
++K+LV I P ++TL C+ +G P P ++W + + ++
Sbjct: 597 ALKVLVPPNIEPGPVNKAVLENASVTLECLASG-VPPPDVSWFKGHQPVSSWMGVTVSVD 655
Query: 63 GGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQI 122
G L I DAG+Y C+A+N G+ + +R R + P + +
Sbjct: 656 GRVLRIEQAQLSDAGSYRCVASNVAGSTELRYG---LRVNVPPRITLPPS---LPGPVLV 709
Query: 123 GREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTD 182
V+++C PS T W K+G P+ + + V PG L + + +D
Sbjct: 710 NTPVRLTCNATGAPSP--TLMWLKDGNPVSPAGTPGL-----QVFPGGRVLTLASARASD 762
Query: 183 FGTYTCVA-SLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGK 241
G Y+CVA S G D+ + V+ +PP++ + +V E ++ L+CQ
Sbjct: 763 SGRYSCVAVSAVGEDRQDVVLQVH-----MPPSILGEELNVSVVANE--SVALECQSHAM 815
Query: 242 PKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREA 301
P P++ W + D P + + + L++ +G Y C+ G + K
Sbjct: 816 PPPVLSWWK-DGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNL 874
Query: 302 LVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCR 333
V + + P E L +R+G ++ CR
Sbjct: 875 NVWVAPVF-PLRESHTLTVREGHPTRLSCECR 905
Score = 75.1 bits (183), Expect = 2e-13
Identities = 93/379 (24%), Positives = 152/379 (40%), Gaps = 42/379 (11%)
Query: 24 VVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLN----GGTLTIPAITSDDAGTY 79
VV G A TL C TG +P P++TW R + + L G +L + + G Y
Sbjct: 988 VVQDGVA-TLECNATG-KPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRY 1045
Query: 80 SCIANNNVGNPAKK-STNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSE 138
SC+A N G +K +++V G DP NI ++ EA+
Sbjct: 1046 SCVAENLAGRAERKFELSVLVPPELIGDL----DPL---TNITAALHSPLTLLCEAMGIP 1098
Query: 139 ELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGIS 198
WF+ P+ E D + G L + + D G Y+C+AS + G
Sbjct: 1099 PPAIRWFRGEEPVSPGE-------DTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEAR 1151
Query: 199 -DISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAM 257
+ S++V VPP++ + + +G T L C VTG P+P + W + + +A
Sbjct: 1152 RNFSVEV-----LVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLAR 1206
Query: 258 PDGSMQMESYDGT-LRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAV--- 313
G S DG L+++ + +G Y C + G K QL V P +
Sbjct: 1207 --GDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKH----FQLSVLLAPTILGG 1260
Query: 314 --EPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTE-YAVK 370
+ A E+ + +++ C L A+P +T+ + G + T +
Sbjct: 1261 AEDSADEEVTVTVNNPISLICEAL-AFPSPNITW-MKDGAPFEASRNIQLLPGTHGLQIL 1318
Query: 371 SLSNENYGVYNCSIINEAG 389
+ E+ G Y C + NE G
Sbjct: 1319 NAQKEDAGQYTCVVTNELG 1337
Score = 71.6 bits (174), Expect = 2e-12
Identities = 88/348 (25%), Positives = 142/348 (40%), Gaps = 57/348 (16%)
Query: 20 DDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLP--EKTVLNGGT--LTIPAITSDD 75
D+ + V I+L+C P+P++TW++ L GT L I +D
Sbjct: 1266 DEEVTVTVNNPISLICEALAF-PSPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKED 1324
Query: 76 AGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNI-QIG-REVK------ 127
AG Y+C+ N +G K N V L P KDD + ++G +EVK
Sbjct: 1325 AGQYTCVVTNELGEAVK---NYHVEVL-------IPPSISKDDPLAEVGVKEVKTKVNST 1374
Query: 128 --ISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGT 185
+ C+ AVP T W+K+G+P+ S R+ + + G L I + +D G
Sbjct: 1375 LTLECESWAVPPP--TIRWYKDGQPVTPSSRLQV------LGEGRL-LQIQPTQVSDSGR 1425
Query: 186 YTCVA-SLKGGGISDISIDVNI--------SSSTVPPNLTVPQEKSPLVTREGDTIE--- 233
Y CVA ++ G D ++ + + S L+ +E VT + +E
Sbjct: 1426 YLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNP 1485
Query: 234 --LQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQY 291
L C P P + W R D+ ++ D ++ L+I V E +G Y C+ S
Sbjct: 1486 AYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQG-GRVLQIPLVRAENAGRYSCKASNE 1544
Query: 292 NGFNVKPREALVQLIVQYPPAV----EPAFLEIRQGQDRSVTMSCRVL 335
G + E L+V PP + E E+ +V++ C L
Sbjct: 1545 VGEDWLHYE----LLVLTPPVILGDTEELVEEVTVNASSTVSLQCPAL 1588
Score = 71.2 bits (173), Expect = 3e-12
Identities = 93/394 (23%), Positives = 157/394 (39%), Gaps = 66/394 (16%)
Query: 28 GEAITLVCVTTGGEPAPSLTWVRS------------------FGTLPEKTVLNGG-TLTI 68
G+++TL C G P P + W++ +G + +L+ G +L
Sbjct: 33 GQSLTLEC-DANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHF 91
Query: 69 PAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQ-----IG 123
P I D+G YSC A N G A++ +++V +TP Q G
Sbjct: 92 PRIQEGDSGLYSCRAENQAGT-AQRDFHLLV---------LTPPSVLGAGAAQEVLGLAG 141
Query: 124 REVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDF 183
+V++ C VP+ ++ W K+ +P+ + Q D V L I D
Sbjct: 142 ADVELQCWTSGVPTPQV--EWTKDRQPVLPGGPHLQVQEDGQV------LRITGSHVGDE 193
Query: 184 GTYTCVA-SLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKP 242
G Y CVA S G D + V+ PP + E + E ++L C+ G P
Sbjct: 194 GRYQCVAFSPAGQQARDFQLRVH-----APPTIWGSNETGEVAVMEDHLVQLLCEARGVP 248
Query: 243 KPIILWSRADKEVAMPDGSMQMESYDG-TLRIVNVSREMSGMYRCQTSQYNGFNVKPREA 301
P I W + +P + + + G L++ +G+Y C+ S G E
Sbjct: 249 TPNITWFK--DGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVG----AAEK 302
Query: 302 LVQLIVQYPPAVEPAF---LEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQ 358
+L V PP +E A ++ R V + C V R +P L++ G + +
Sbjct: 303 ATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALEC-VARGHPSPTLSWHHE-GLPVAESN- 359
Query: 359 FDSQEYTEYAV---KSLSNENYGVYNCSIINEAG 389
+S+ T+ +V +S + G+Y+C + AG
Sbjct: 360 -ESRLETDGSVLRLESPGEASSGLYSCVASSPAG 392
Score = 67.8 bits (164), Expect = 3e-11
Identities = 92/390 (23%), Positives = 148/390 (37%), Gaps = 54/390 (13%)
Query: 27 PGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLN----GGTLTIPAITSDDAGTYSCI 82
PG+ + L C + EPAP +TW R L E G L + A+++ D+G YSC
Sbjct: 2314 PGQLV-LEC-SVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCT 2371
Query: 83 ANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTF 142
A N G ST++ R I P N+ + + + CQ + VP+ +
Sbjct: 2372 ARNAAG-----STSVAFRVEIHTVPTIRSGP--PAVNVSVNQTALLPCQADGVPAPLV-- 2422
Query: 143 SWFKNGRPL--RSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGIS-- 198
SW K+ PL RS ++ + + P D G Y C+AS G
Sbjct: 2423 SWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQ---------DAGHYLCLASNSAGSDRQG 2473
Query: 199 -DISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAM 257
D+ + + + P NLT+ L L C+ +G PKP+++W + +++
Sbjct: 2474 RDLRVLEPPAIAPSPSNLTLTAHTPAL---------LPCEASGSPKPLVVWWKDGQKL-- 2522
Query: 258 PDGSMQMESY----DGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAV 313
D +Q +Y L + + S + C S V L Q+ V PP +
Sbjct: 2523 -DFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSN----EVGEAHRLYQVTVHVPPTI 2577
Query: 314 EPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEW-RLGNKL-LRTGQFDSQEYTEYAVKS 371
+ V ++C + I T W + G +L R + +
Sbjct: 2578 ADDQTDFTVTMMAPVVLTC---HSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQ 2634
Query: 372 LSNENYGVYNCSIINEAGAGRCSFLVTGKA 401
+ G Y CS N AG +T +A
Sbjct: 2635 ALPIHAGRYTCSARNSAGVAHKHVFLTVQA 2664
Score = 64.7 bits (156), Expect = 3e-10
Identities = 92/398 (23%), Positives = 156/398 (39%), Gaps = 47/398 (11%)
Query: 13 PSIKLLVDDPIVVNP--GEAITLVCVTTGGEPAPSLTWVRSFGTLPE----KTVLNGGTL 66
P+I+ P VV G + L CV G P+P+L+W + E + +G L
Sbjct: 312 PTIEGAGGRPYVVKAVAGRPVALECVARG-HPSPTLSWHHEGLPVAESNESRLETDGSVL 370
Query: 67 TIPAITSDDAGTYSCIANNNVGNPAKK-STNIIVRA---LKKGRFWITPDPYHKDDNIQI 122
+ + +G YSC+A++ G + S + V + +G +T +
Sbjct: 371 RLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTI---------V 421
Query: 123 GREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTD 182
G+ +++ CQ P T W +NGRP +E + Q S GTT L I ++
Sbjct: 422 GQPLELPCQASGSPVP--TIQWLQNGRP---AEELAGVQV---ASQGTT-LHIDHVELDH 472
Query: 183 FGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVT--- 239
G + C A+ + G + ++V++ P L VP + + C
Sbjct: 473 SGLFACQATNEAG-TAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHR 531
Query: 240 ---GKPKPIIL--WSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGF 294
PKP ++ W P G S L+I V G+Y C + G
Sbjct: 532 GWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGE 591
Query: 295 NVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLL 354
+ RE ++++V PP +EP + ++ SVT+ C P V W G++ +
Sbjct: 592 S--KREVALKVLV--PPNIEPGPVNKAVLENASVTLECLASGVPPPDV---SWFKGHQPV 644
Query: 355 RT--GQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGA 390
+ G S + ++ + G Y C N AG+
Sbjct: 645 SSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGS 682
Score = 46.6 bits (109), Expect = 8e-05
Identities = 55/216 (25%), Positives = 85/216 (39%), Gaps = 21/216 (9%)
Query: 182 DFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGK 241
D G Y+C A + G D ++ T PP++ ++ G +ELQC +G
Sbjct: 98 DSGLYSCRAENQAGTAQR---DFHLLVLT-PPSVLGAGAAQEVLGLAGADVELQCWTSGV 153
Query: 242 PKPIILWSRADKEVAMPDG-SMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPRE 300
P P + W++ D++ +P G +Q++ LRI G Y+C G +
Sbjct: 154 PTPQVEWTK-DRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARD-- 210
Query: 301 ALVQLIVQYPPAV--EPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQ 358
QL V PP + E+ +D V + C R P +T W LL T
Sbjct: 211 --FQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEA-RGVPTPNIT--WFKDGALLPTS- 264
Query: 359 FDSQEYT----EYAVKSLSNENYGVYNCSIINEAGA 390
YT + + + + GVY C N GA
Sbjct: 265 -TKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGA 299
Score = 45.4 bits (106), Expect = 2e-04
Identities = 26/86 (30%), Positives = 47/86 (54%), Gaps = 5/86 (5%)
Query: 23 IVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKT---VLNGGTLTIPAITSDDAGTY 79
+ V G+ + L C TG EP P++ W+++ L L G+L + + + DAGTY
Sbjct: 3036 MTVRSGDDVALRCQATG-EPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTY 3094
Query: 80 SCIANNNVGNPAKKSTNIIVRALKKG 105
C+A+N +G+ ++ ++VR +G
Sbjct: 3095 DCVAHNLLGSATARAF-LVVRGEPQG 3119
Score = 36.6 bits (83), Expect = 0.085
Identities = 27/121 (22%), Positives = 48/121 (39%), Gaps = 18/121 (14%)
Query: 207 SSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMP-------- 258
+ S VPP++ K+ + G ++ L+C G P P I+W + + V +P
Sbjct: 11 TGSVVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGW 70
Query: 259 ------DGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPA 312
G ++ +L + SG+Y C+ G + L+V PP+
Sbjct: 71 DLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAG----TAQRDFHLLVLTPPS 126
Query: 313 V 313
V
Sbjct: 127 V 127
>gi|224994173 roundabout 1 isoform d [Homo sapiens]
Length = 1551
Score = 94.4 bits (233), Expect = 3e-19
Identities = 102/370 (27%), Positives = 147/370 (39%), Gaps = 54/370 (14%)
Query: 11 ASPSIKLLVDD------PIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKT---VL 61
AS + +L DD ++V GE + C G P P+++W + L +K +
Sbjct: 122 ASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITI 181
Query: 62 NGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQ 121
GG L I DAG Y C+ N VG + + V L++ F P + +
Sbjct: 182 RGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTV--LERPSF--VKRPSNLAVTVD 237
Query: 122 IGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFT 181
E K + + VP T W K+ L S + L I +
Sbjct: 238 DSAEFKCEARGDPVP----TVRWRKDDGELPKSRYEI---------RDDHTLKIRKVTAG 284
Query: 182 DFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTV-PQEKSPLVTREGDTIELQCQVTG 240
D G+YTCVA G ++ S + + + PP+ V P+++ V G T+ QC+ TG
Sbjct: 285 DMGSYTCVAE-NMVGKAEASATLTVQVGSEPPHFVVKPRDQ---VVALGRTVTFQCEATG 340
Query: 241 KPKPIILWSRADKEVAM-----PDGSMQME-SYDGTLRIVNVSREMSGMYRCQTSQYNGF 294
P+P I W R + + P S + S G L I NV R G Y CQT G
Sbjct: 341 NPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGS 400
Query: 295 NV-KPREALVQLIVQYPPAVEPAFLEIRQGQ-------DRSVTMSCRVLRAYPIRVLTYE 346
+ K + +I PP V IRQG D + +SC V P V T
Sbjct: 401 IITKAYLEVTDVIADRPPPV------IRQGPVNQTVAVDGTFVLSC-VATGSP--VPTIL 451
Query: 347 WRLGNKLLRT 356
WR L+ T
Sbjct: 452 WRKDGVLVST 461
Score = 87.0 bits (214), Expect = 5e-17
Identities = 72/267 (26%), Positives = 118/267 (44%), Gaps = 31/267 (11%)
Query: 40 GEPAPSLTWVRSFGTLPEKT--VLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNI 97
G+P P++ W + G LP+ + + TL I +T+ D G+Y+C+A N VG +T
Sbjct: 248 GDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLT 307
Query: 98 IVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVP----------SEELTFSWFKN 147
+ + F + P +D + +GR V C+ P S+ L FS+
Sbjct: 308 VQVGSEPPHFVVKP----RDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSY--- 360
Query: 148 GRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTC-VASLKGGGISDISIDVNI 206
+P +SS R ++QT +L I +++ +D G Y C ++ G I+ ++V
Sbjct: 361 -QPPQSSSRFSVSQTG--------DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTD 411
Query: 207 SSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMES 266
+ PP + + V +G T L C TG P P ILW R D + S +
Sbjct: 412 VIADRPPPVIRQGPVNQTVAVDG-TFVLSCVATGSPVPTILW-RKDGVLVSTQDSRIKQL 469
Query: 267 YDGTLRIVNVSREMSGMYRCQTSQYNG 293
+G L+I +G Y C S +G
Sbjct: 470 ENGVLQIRYAKLGDTGRYTCIASTPSG 496
Score = 77.4 bits (189), Expect = 4e-14
Identities = 94/400 (23%), Positives = 154/400 (38%), Gaps = 57/400 (14%)
Query: 18 LVDDP--IVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLP--------EKTVLNGGTLT 67
+V+ P ++V+ GE TL C G P P++ W + + + +L G+L
Sbjct: 31 IVEHPSDLIVSKGEPATLNCKAEG-RPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLF 89
Query: 68 IPAI-----TSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQI 122
I + D G Y C+A N +G + ++ V A+ + F P D + +
Sbjct: 90 FLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEV-AILRDDFRQNP----SDVMVAV 144
Query: 123 GREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTD 182
G + CQ E T SW K+G PL + + + L I + +D
Sbjct: 145 GEPAVMECQPPR-GHPEPTISWKKDGSPLDDKDERITIRGG--------KLMITYTRKSD 195
Query: 183 FGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKP 242
G Y CV + G + ++ TV + + S L D+ E +C+ G P
Sbjct: 196 AGKYVCVGTNMVG-----ERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDP 250
Query: 243 KPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREAL 302
P + W + D E +P ++ D TL+I V+ G Y C G EA
Sbjct: 251 VPTVRWRKDDGE--LPKSRYEIRD-DHTLKIRKVTAGDMGSYTCVAENMVG----KAEAS 303
Query: 303 VQLIVQY---PP--AVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLL--- 354
L VQ PP V+P + G R+VT C P + + LL
Sbjct: 304 ATLTVQVGSEPPHFVVKPRDQVVALG--RTVTFQCEA-TGNPQPAIFWRREGSQNLLFSY 360
Query: 355 ----RTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGA 390
+ +F + + + ++ + G Y C +N AG+
Sbjct: 361 QPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGS 400
Score = 43.9 bits (102), Expect = 5e-04
Identities = 62/287 (21%), Positives = 110/287 (38%), Gaps = 33/287 (11%)
Query: 123 GREVKISCQVEAVPSEELTFSWFKNGRPLRS------SERMVITQTDPDVSPGTTNLDII 176
G ++C+ E P+ T W+K G + + S RM++ S L I+
Sbjct: 43 GEPATLNCKAEGRPTP--TIEWYKGGERVETDKDDPRSHRMLLP------SGSLFFLRIV 94
Query: 177 DLKFT--DFGTYTCVA-SLKGGGIS-DISIDVNISSSTVPPNLTVPQEKSPLVTREGDTI 232
+ + D G Y CVA + G +S + S++V I N S ++ G+
Sbjct: 95 HGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQN------PSDVMVAVGEPA 148
Query: 233 ELQCQVT-GKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQY 291
++CQ G P+P I W + + D + + G L I + +G Y C +
Sbjct: 149 VMECQPPRGHPEPTISWKKDGSPLDDKDERITIRG--GKLMITYTRKSDAGKYVCVGTNM 206
Query: 292 NGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGN 351
G + + +L V P+ + D S C R P+ T WR +
Sbjct: 207 VG---ERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEA-RGDPVP--TVRWRKDD 260
Query: 352 KLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVT 398
L +++ ++ ++ ++ + G Y C N G S +T
Sbjct: 261 GELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLT 307
Score = 40.8 bits (94), Expect = 0.004
Identities = 36/149 (24%), Positives = 62/149 (41%), Gaps = 24/149 (16%)
Query: 212 PPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEV------------AMPD 259
PP + + S L+ +G+ L C+ G+P P I W + + V +P
Sbjct: 28 PPRIV--EHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 85
Query: 260 GSMQMESYDGTLRIVN--VSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAF 317
GS+ LRIV+ SR G+Y C Y G V +L I++ P+
Sbjct: 86 GSLFF------LRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSD 139
Query: 318 LEIRQGQDRSVTMSCRVLRAYPIRVLTYE 346
+ + G+ M C+ R +P ++++
Sbjct: 140 VMVAVGE--PAVMECQPPRGHPEPTISWK 166
>gi|224994171 roundabout 1 isoform c [Homo sapiens]
Length = 1606
Score = 94.4 bits (233), Expect = 3e-19
Identities = 102/370 (27%), Positives = 147/370 (39%), Gaps = 54/370 (14%)
Query: 11 ASPSIKLLVDD------PIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKT---VL 61
AS + +L DD ++V GE + C G P P+++W + L +K +
Sbjct: 122 ASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITI 181
Query: 62 NGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQ 121
GG L I DAG Y C+ N VG + + V L++ F P + +
Sbjct: 182 RGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTV--LERPSF--VKRPSNLAVTVD 237
Query: 122 IGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFT 181
E K + + VP T W K+ L S + L I +
Sbjct: 238 DSAEFKCEARGDPVP----TVRWRKDDGELPKSRYEI---------RDDHTLKIRKVTAG 284
Query: 182 DFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTV-PQEKSPLVTREGDTIELQCQVTG 240
D G+YTCVA G ++ S + + + PP+ V P+++ V G T+ QC+ TG
Sbjct: 285 DMGSYTCVAE-NMVGKAEASATLTVQVGSEPPHFVVKPRDQ---VVALGRTVTFQCEATG 340
Query: 241 KPKPIILWSRADKEVAM-----PDGSMQME-SYDGTLRIVNVSREMSGMYRCQTSQYNGF 294
P+P I W R + + P S + S G L I NV R G Y CQT G
Sbjct: 341 NPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGS 400
Query: 295 NV-KPREALVQLIVQYPPAVEPAFLEIRQGQ-------DRSVTMSCRVLRAYPIRVLTYE 346
+ K + +I PP V IRQG D + +SC V P V T
Sbjct: 401 IITKAYLEVTDVIADRPPPV------IRQGPVNQTVAVDGTFVLSC-VATGSP--VPTIL 451
Query: 347 WRLGNKLLRT 356
WR L+ T
Sbjct: 452 WRKDGVLVST 461
Score = 87.0 bits (214), Expect = 5e-17
Identities = 72/267 (26%), Positives = 118/267 (44%), Gaps = 31/267 (11%)
Query: 40 GEPAPSLTWVRSFGTLPEKT--VLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNI 97
G+P P++ W + G LP+ + + TL I +T+ D G+Y+C+A N VG +T
Sbjct: 248 GDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLT 307
Query: 98 IVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVP----------SEELTFSWFKN 147
+ + F + P +D + +GR V C+ P S+ L FS+
Sbjct: 308 VQVGSEPPHFVVKP----RDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSY--- 360
Query: 148 GRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTC-VASLKGGGISDISIDVNI 206
+P +SS R ++QT +L I +++ +D G Y C ++ G I+ ++V
Sbjct: 361 -QPPQSSSRFSVSQTG--------DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTD 411
Query: 207 SSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMES 266
+ PP + + V +G T L C TG P P ILW R D + S +
Sbjct: 412 VIADRPPPVIRQGPVNQTVAVDG-TFVLSCVATGSPVPTILW-RKDGVLVSTQDSRIKQL 469
Query: 267 YDGTLRIVNVSREMSGMYRCQTSQYNG 293
+G L+I +G Y C S +G
Sbjct: 470 ENGVLQIRYAKLGDTGRYTCIASTPSG 496
Score = 77.4 bits (189), Expect = 4e-14
Identities = 94/400 (23%), Positives = 154/400 (38%), Gaps = 57/400 (14%)
Query: 18 LVDDP--IVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLP--------EKTVLNGGTLT 67
+V+ P ++V+ GE TL C G P P++ W + + + +L G+L
Sbjct: 31 IVEHPSDLIVSKGEPATLNCKAEG-RPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLF 89
Query: 68 IPAI-----TSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQI 122
I + D G Y C+A N +G + ++ V A+ + F P D + +
Sbjct: 90 FLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEV-AILRDDFRQNP----SDVMVAV 144
Query: 123 GREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTD 182
G + CQ E T SW K+G PL + + + L I + +D
Sbjct: 145 GEPAVMECQPPR-GHPEPTISWKKDGSPLDDKDERITIRGG--------KLMITYTRKSD 195
Query: 183 FGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKP 242
G Y CV + G + ++ TV + + S L D+ E +C+ G P
Sbjct: 196 AGKYVCVGTNMVG-----ERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDP 250
Query: 243 KPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREAL 302
P + W + D E +P ++ D TL+I V+ G Y C G EA
Sbjct: 251 VPTVRWRKDDGE--LPKSRYEIRD-DHTLKIRKVTAGDMGSYTCVAENMVG----KAEAS 303
Query: 303 VQLIVQY---PP--AVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLL--- 354
L VQ PP V+P + G R+VT C P + + LL
Sbjct: 304 ATLTVQVGSEPPHFVVKPRDQVVALG--RTVTFQCEA-TGNPQPAIFWRREGSQNLLFSY 360
Query: 355 ----RTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGA 390
+ +F + + + ++ + G Y C +N AG+
Sbjct: 361 QPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGS 400
Score = 43.9 bits (102), Expect = 5e-04
Identities = 62/287 (21%), Positives = 110/287 (38%), Gaps = 33/287 (11%)
Query: 123 GREVKISCQVEAVPSEELTFSWFKNGRPLRS------SERMVITQTDPDVSPGTTNLDII 176
G ++C+ E P+ T W+K G + + S RM++ S L I+
Sbjct: 43 GEPATLNCKAEGRPTP--TIEWYKGGERVETDKDDPRSHRMLLP------SGSLFFLRIV 94
Query: 177 DLKFT--DFGTYTCVA-SLKGGGIS-DISIDVNISSSTVPPNLTVPQEKSPLVTREGDTI 232
+ + D G Y CVA + G +S + S++V I N S ++ G+
Sbjct: 95 HGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQN------PSDVMVAVGEPA 148
Query: 233 ELQCQVT-GKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQY 291
++CQ G P+P I W + + D + + G L I + +G Y C +
Sbjct: 149 VMECQPPRGHPEPTISWKKDGSPLDDKDERITIRG--GKLMITYTRKSDAGKYVCVGTNM 206
Query: 292 NGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGN 351
G + + +L V P+ + D S C R P+ T WR +
Sbjct: 207 VG---ERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEA-RGDPVP--TVRWRKDD 260
Query: 352 KLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVT 398
L +++ ++ ++ ++ + G Y C N G S +T
Sbjct: 261 GELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLT 307
Score = 40.8 bits (94), Expect = 0.004
Identities = 36/149 (24%), Positives = 62/149 (41%), Gaps = 24/149 (16%)
Query: 212 PPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEV------------AMPD 259
PP + + S L+ +G+ L C+ G+P P I W + + V +P
Sbjct: 28 PPRIV--EHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 85
Query: 260 GSMQMESYDGTLRIVN--VSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAF 317
GS+ LRIV+ SR G+Y C Y G V +L I++ P+
Sbjct: 86 GSLFF------LRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSD 139
Query: 318 LEIRQGQDRSVTMSCRVLRAYPIRVLTYE 346
+ + G+ M C+ R +P ++++
Sbjct: 140 VMVAVGE--PAVMECQPPRGHPEPTISWK 166
>gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo
sapiens]
Length = 1562
Score = 94.4 bits (233), Expect = 3e-19
Identities = 102/370 (27%), Positives = 147/370 (39%), Gaps = 54/370 (14%)
Query: 11 ASPSIKLLVDD------PIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKT---VL 61
AS + +L DD ++V GE + C G P P+++W + L +K +
Sbjct: 122 ASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITI 181
Query: 62 NGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQ 121
GG L I DAG Y C+ N VG + + V L++ F P + +
Sbjct: 182 RGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTV--LERPSF--VKRPSNLAVTVD 237
Query: 122 IGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFT 181
E K + + VP T W K+ L S + L I +
Sbjct: 238 DSAEFKCEARGDPVP----TVRWRKDDGELPKSRYEI---------RDDHTLKIRKVTAG 284
Query: 182 DFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTV-PQEKSPLVTREGDTIELQCQVTG 240
D G+YTCVA G ++ S + + + PP+ V P+++ V G T+ QC+ TG
Sbjct: 285 DMGSYTCVAE-NMVGKAEASATLTVQVGSEPPHFVVKPRDQ---VVALGRTVTFQCEATG 340
Query: 241 KPKPIILWSRADKEVAM-----PDGSMQME-SYDGTLRIVNVSREMSGMYRCQTSQYNGF 294
P+P I W R + + P S + S G L I NV R G Y CQT G
Sbjct: 341 NPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGS 400
Query: 295 NV-KPREALVQLIVQYPPAVEPAFLEIRQGQ-------DRSVTMSCRVLRAYPIRVLTYE 346
+ K + +I PP V IRQG D + +SC V P V T
Sbjct: 401 IITKAYLEVTDVIADRPPPV------IRQGPVNQTVAVDGTFVLSC-VATGSP--VPTIL 451
Query: 347 WRLGNKLLRT 356
WR L+ T
Sbjct: 452 WRKDGVLVST 461
Score = 87.0 bits (214), Expect = 5e-17
Identities = 72/267 (26%), Positives = 118/267 (44%), Gaps = 31/267 (11%)
Query: 40 GEPAPSLTWVRSFGTLPEKT--VLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNI 97
G+P P++ W + G LP+ + + TL I +T+ D G+Y+C+A N VG +T
Sbjct: 248 GDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLT 307
Query: 98 IVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVP----------SEELTFSWFKN 147
+ + F + P +D + +GR V C+ P S+ L FS+
Sbjct: 308 VQVGSEPPHFVVKP----RDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSY--- 360
Query: 148 GRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTC-VASLKGGGISDISIDVNI 206
+P +SS R ++QT +L I +++ +D G Y C ++ G I+ ++V
Sbjct: 361 -QPPQSSSRFSVSQTG--------DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTD 411
Query: 207 SSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMES 266
+ PP + + V +G T L C TG P P ILW R D + S +
Sbjct: 412 VIADRPPPVIRQGPVNQTVAVDG-TFVLSCVATGSPVPTILW-RKDGVLVSTQDSRIKQL 469
Query: 267 YDGTLRIVNVSREMSGMYRCQTSQYNG 293
+G L+I +G Y C S +G
Sbjct: 470 ENGVLQIRYAKLGDTGRYTCIASTPSG 496
Score = 77.4 bits (189), Expect = 4e-14
Identities = 94/400 (23%), Positives = 154/400 (38%), Gaps = 57/400 (14%)
Query: 18 LVDDP--IVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLP--------EKTVLNGGTLT 67
+V+ P ++V+ GE TL C G P P++ W + + + +L G+L
Sbjct: 31 IVEHPSDLIVSKGEPATLNCKAEG-RPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLF 89
Query: 68 IPAI-----TSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQI 122
I + D G Y C+A N +G + ++ V A+ + F P D + +
Sbjct: 90 FLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEV-AILRDDFRQNP----SDVMVAV 144
Query: 123 GREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTD 182
G + CQ E T SW K+G PL + + + L I + +D
Sbjct: 145 GEPAVMECQPPR-GHPEPTISWKKDGSPLDDKDERITIRGG--------KLMITYTRKSD 195
Query: 183 FGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKP 242
G Y CV + G + ++ TV + + S L D+ E +C+ G P
Sbjct: 196 AGKYVCVGTNMVG-----ERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDP 250
Query: 243 KPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREAL 302
P + W + D E +P ++ D TL+I V+ G Y C G EA
Sbjct: 251 VPTVRWRKDDGE--LPKSRYEIRD-DHTLKIRKVTAGDMGSYTCVAENMVG----KAEAS 303
Query: 303 VQLIVQY---PP--AVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLL--- 354
L VQ PP V+P + G R+VT C P + + LL
Sbjct: 304 ATLTVQVGSEPPHFVVKPRDQVVALG--RTVTFQCEA-TGNPQPAIFWRREGSQNLLFSY 360
Query: 355 ----RTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGA 390
+ +F + + + ++ + G Y C +N AG+
Sbjct: 361 QPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGS 400
Score = 43.9 bits (102), Expect = 5e-04
Identities = 62/287 (21%), Positives = 110/287 (38%), Gaps = 33/287 (11%)
Query: 123 GREVKISCQVEAVPSEELTFSWFKNGRPLRS------SERMVITQTDPDVSPGTTNLDII 176
G ++C+ E P+ T W+K G + + S RM++ S L I+
Sbjct: 43 GEPATLNCKAEGRPTP--TIEWYKGGERVETDKDDPRSHRMLLP------SGSLFFLRIV 94
Query: 177 DLKFT--DFGTYTCVA-SLKGGGIS-DISIDVNISSSTVPPNLTVPQEKSPLVTREGDTI 232
+ + D G Y CVA + G +S + S++V I N S ++ G+
Sbjct: 95 HGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQN------PSDVMVAVGEPA 148
Query: 233 ELQCQVT-GKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQY 291
++CQ G P+P I W + + D + + G L I + +G Y C +
Sbjct: 149 VMECQPPRGHPEPTISWKKDGSPLDDKDERITIRG--GKLMITYTRKSDAGKYVCVGTNM 206
Query: 292 NGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGN 351
G + + +L V P+ + D S C R P+ T WR +
Sbjct: 207 VG---ERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEA-RGDPVP--TVRWRKDD 260
Query: 352 KLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVT 398
L +++ ++ ++ ++ + G Y C N G S +T
Sbjct: 261 GELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLT 307
Score = 40.8 bits (94), Expect = 0.004
Identities = 36/149 (24%), Positives = 62/149 (41%), Gaps = 24/149 (16%)
Query: 212 PPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEV------------AMPD 259
PP + + S L+ +G+ L C+ G+P P I W + + V +P
Sbjct: 28 PPRIV--EHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 85
Query: 260 GSMQMESYDGTLRIVN--VSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAF 317
GS+ LRIV+ SR G+Y C Y G V +L I++ P+
Sbjct: 86 GSLFF------LRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSD 139
Query: 318 LEIRQGQDRSVTMSCRVLRAYPIRVLTYE 346
+ + G+ M C+ R +P ++++
Sbjct: 140 VMVAVGE--PAVMECQPPRGHPEPTISWK 166
>gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo
sapiens]
Length = 1615
Score = 94.4 bits (233), Expect = 3e-19
Identities = 102/370 (27%), Positives = 147/370 (39%), Gaps = 54/370 (14%)
Query: 11 ASPSIKLLVDD------PIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKT---VL 61
AS + +L DD ++V GE + C G P P+++W + L +K +
Sbjct: 122 ASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITI 181
Query: 62 NGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQ 121
GG L I DAG Y C+ N VG + + V L++ F P + +
Sbjct: 182 RGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTV--LERPSF--VKRPSNLAVTVD 237
Query: 122 IGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFT 181
E K + + VP T W K+ L S + L I +
Sbjct: 238 DSAEFKCEARGDPVP----TVRWRKDDGELPKSRYEI---------RDDHTLKIRKVTAG 284
Query: 182 DFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTV-PQEKSPLVTREGDTIELQCQVTG 240
D G+YTCVA G ++ S + + + PP+ V P+++ V G T+ QC+ TG
Sbjct: 285 DMGSYTCVAE-NMVGKAEASATLTVQVGSEPPHFVVKPRDQ---VVALGRTVTFQCEATG 340
Query: 241 KPKPIILWSRADKEVAM-----PDGSMQME-SYDGTLRIVNVSREMSGMYRCQTSQYNGF 294
P+P I W R + + P S + S G L I NV R G Y CQT G
Sbjct: 341 NPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGS 400
Query: 295 NV-KPREALVQLIVQYPPAVEPAFLEIRQGQ-------DRSVTMSCRVLRAYPIRVLTYE 346
+ K + +I PP V IRQG D + +SC V P V T
Sbjct: 401 IITKAYLEVTDVIADRPPPV------IRQGPVNQTVAVDGTFVLSC-VATGSP--VPTIL 451
Query: 347 WRLGNKLLRT 356
WR L+ T
Sbjct: 452 WRKDGVLVST 461
Score = 87.0 bits (214), Expect = 5e-17
Identities = 72/267 (26%), Positives = 118/267 (44%), Gaps = 31/267 (11%)
Query: 40 GEPAPSLTWVRSFGTLPEKT--VLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNI 97
G+P P++ W + G LP+ + + TL I +T+ D G+Y+C+A N VG +T
Sbjct: 248 GDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLT 307
Query: 98 IVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVP----------SEELTFSWFKN 147
+ + F + P +D + +GR V C+ P S+ L FS+
Sbjct: 308 VQVGSEPPHFVVKP----RDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSY--- 360
Query: 148 GRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTC-VASLKGGGISDISIDVNI 206
+P +SS R ++QT +L I +++ +D G Y C ++ G I+ ++V
Sbjct: 361 -QPPQSSSRFSVSQTG--------DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTD 411
Query: 207 SSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMES 266
+ PP + + V +G T L C TG P P ILW R D + S +
Sbjct: 412 VIADRPPPVIRQGPVNQTVAVDG-TFVLSCVATGSPVPTILW-RKDGVLVSTQDSRIKQL 469
Query: 267 YDGTLRIVNVSREMSGMYRCQTSQYNG 293
+G L+I +G Y C S +G
Sbjct: 470 ENGVLQIRYAKLGDTGRYTCIASTPSG 496
Score = 77.4 bits (189), Expect = 4e-14
Identities = 94/400 (23%), Positives = 154/400 (38%), Gaps = 57/400 (14%)
Query: 18 LVDDP--IVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLP--------EKTVLNGGTLT 67
+V+ P ++V+ GE TL C G P P++ W + + + +L G+L
Sbjct: 31 IVEHPSDLIVSKGEPATLNCKAEG-RPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLF 89
Query: 68 IPAI-----TSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQI 122
I + D G Y C+A N +G + ++ V A+ + F P D + +
Sbjct: 90 FLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEV-AILRDDFRQNP----SDVMVAV 144
Query: 123 GREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTD 182
G + CQ E T SW K+G PL + + + L I + +D
Sbjct: 145 GEPAVMECQPPR-GHPEPTISWKKDGSPLDDKDERITIRGG--------KLMITYTRKSD 195
Query: 183 FGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKP 242
G Y CV + G + ++ TV + + S L D+ E +C+ G P
Sbjct: 196 AGKYVCVGTNMVG-----ERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDP 250
Query: 243 KPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREAL 302
P + W + D E +P ++ D TL+I V+ G Y C G EA
Sbjct: 251 VPTVRWRKDDGE--LPKSRYEIRD-DHTLKIRKVTAGDMGSYTCVAENMVG----KAEAS 303
Query: 303 VQLIVQY---PP--AVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLL--- 354
L VQ PP V+P + G R+VT C P + + LL
Sbjct: 304 ATLTVQVGSEPPHFVVKPRDQVVALG--RTVTFQCEA-TGNPQPAIFWRREGSQNLLFSY 360
Query: 355 ----RTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGA 390
+ +F + + + ++ + G Y C +N AG+
Sbjct: 361 QPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGS 400
Score = 43.9 bits (102), Expect = 5e-04
Identities = 62/287 (21%), Positives = 110/287 (38%), Gaps = 33/287 (11%)
Query: 123 GREVKISCQVEAVPSEELTFSWFKNGRPLRS------SERMVITQTDPDVSPGTTNLDII 176
G ++C+ E P+ T W+K G + + S RM++ S L I+
Sbjct: 43 GEPATLNCKAEGRPTP--TIEWYKGGERVETDKDDPRSHRMLLP------SGSLFFLRIV 94
Query: 177 DLKFT--DFGTYTCVA-SLKGGGIS-DISIDVNISSSTVPPNLTVPQEKSPLVTREGDTI 232
+ + D G Y CVA + G +S + S++V I N S ++ G+
Sbjct: 95 HGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQN------PSDVMVAVGEPA 148
Query: 233 ELQCQVT-GKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQY 291
++CQ G P+P I W + + D + + G L I + +G Y C +
Sbjct: 149 VMECQPPRGHPEPTISWKKDGSPLDDKDERITIRG--GKLMITYTRKSDAGKYVCVGTNM 206
Query: 292 NGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGN 351
G + + +L V P+ + D S C R P+ T WR +
Sbjct: 207 VG---ERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEA-RGDPVP--TVRWRKDD 260
Query: 352 KLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVT 398
L +++ ++ ++ ++ + G Y C N G S +T
Sbjct: 261 GELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLT 307
Score = 40.8 bits (94), Expect = 0.004
Identities = 36/149 (24%), Positives = 62/149 (41%), Gaps = 24/149 (16%)
Query: 212 PPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEV------------AMPD 259
PP + + S L+ +G+ L C+ G+P P I W + + V +P
Sbjct: 28 PPRIV--EHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 85
Query: 260 GSMQMESYDGTLRIVN--VSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAF 317
GS+ LRIV+ SR G+Y C Y G V +L I++ P+
Sbjct: 86 GSLFF------LRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSD 139
Query: 318 LEIRQGQDRSVTMSCRVLRAYPIRVLTYE 346
+ + G+ M C+ R +P ++++
Sbjct: 140 VMVAVGE--PAVMECQPPRGHPEPTISWK 166
>gi|182508169 neuropilin 1 isoform a [Homo sapiens]
Length = 923
Score = 93.2 bits (230), Expect = 8e-19
Identities = 65/189 (34%), Positives = 98/189 (51%), Gaps = 23/189 (12%)
Query: 517 FHCGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPNADRSGSKEGFYMYIETSR 576
F+C F G+ F + DN K S T T GP D +G +G ++Y +
Sbjct: 648 FNCEFGWGSHKTFCHWEHDNHVQLKWSVLTSKT------GPIQDHTG--DGNFIYSQADE 699
Query: 577 PRLEGEKARLLSPVFSIAPKNPYGPTNTAYCFSFFYHMYGQHIGVLNVYLRLKGQTTIEN 636
+ +G+ ARL+SPV N+A+C +F+YHM G H+G L V LR + +
Sbjct: 700 NQ-KGKVARLVSPVVY--------SQNSAHCMTFWYHMSGSHVGTLRVKLRYQKPEEYDQ 750
Query: 637 PLWSSSGNKGQRWNEAHVNIY-PITSFQLIFEGIRGPGIEGDIAIDDVS----IAEGECA 691
+W + G++G W E V ++ + +Q+IFEG G G G IA+DD+S I++ +CA
Sbjct: 751 LVWMAIGHQGDHWKEGRVLLHKSLKLYQVIFEGEIGKGNLGGIAVDDISINNHISQEDCA 810
Query: 692 K-QDLATKN 699
K DL KN
Sbjct: 811 KPADLDKKN 819
>gi|223942069 enterokinase precursor [Homo sapiens]
Length = 1019
Score = 92.4 bits (228), Expect = 1e-18
Identities = 57/176 (32%), Positives = 87/176 (49%), Gaps = 18/176 (10%)
Query: 516 EFHCGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPNADRS-GSKEGFYMYIET 574
+ +C FEDG C + QD D+ +W + +T ++P TGPN D + G+ GFY+ T
Sbjct: 344 KINCNFEDG-FCFWVQDLNDDNEWERIQGST----FSPFTGPNFDHTFGNASGFYISTPT 398
Query: 575 SRPRLEGEKARLLSPVFSIAPKNPYGPTNTAYCFSFFYHMYGQHIGVLNVYLRLKGQTTI 634
P E+ LLS P PT C SF+YHMYG+++ L++ + +
Sbjct: 399 G-PGGRQERVGLLSL--------PLDPTLEPACLSFWYHMYGENVHKLSI--NISNDQNM 447
Query: 635 ENPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGPGIEGDIAIDDVSIAEGEC 690
E ++ GN G WN V + F++ F + I DIA+DD+S+ G C
Sbjct: 448 EKTVFQKEGNYGDNWNYGQVTLNETVKFKVAFNAFKNK-ILSDIALDDISLTYGIC 502
>gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo
sapiens]
Length = 1386
Score = 91.7 bits (226), Expect = 2e-18
Identities = 104/407 (25%), Positives = 170/407 (41%), Gaps = 55/407 (13%)
Query: 7 SNKTASPSIKLLVDD------PIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPE--- 57
+++ AS + +L DD +VV GE L CV G P PS++W + L E
Sbjct: 153 ASRNASLEVAVLRDDFRQSPGNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEG 212
Query: 58 KTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKD 117
+ + GG L + DAG Y C+A+N G + ++V L++ F P +
Sbjct: 213 RITIRGGKLMMSHTLKSDAGMYVCVASNMAGERESAAAEVMV--LERPSFLRRP----VN 266
Query: 118 DNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIID 177
+ V C+V+ P L W K L + + ++D + G + +
Sbjct: 267 QVVLADAPVTFLCEVKGDPPPRL--RWRKEDGELPTGRYEI--RSDHSLWIGHVSAE--- 319
Query: 178 LKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNL-TVPQEKSPLVTREGDTIELQC 236
D GTYTCVA G ++ S +++ VPP L T PQ++ + G+++ QC
Sbjct: 320 ----DEGTYTCVAE-NSVGRAEASGSLSVH---VPPQLVTQPQDQ---MAAPGESVAFQC 368
Query: 237 QVTGKPKPIILWSRADKEVAM-PDGSMQ-----MESYDGTLRIVNVSREMSGMYRCQTSQ 290
+ G P P I W + +V + P S+Q S G L I V R +G Y CQ
Sbjct: 369 ETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVS 428
Query: 291 YNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQ----DRSVTMSCRVLRAYPIRVLTY- 345
G + +AL+++ + P L+ Q SV + CRV P + +
Sbjct: 429 VAGSIL--AKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRV-TGNPQPSVRWK 485
Query: 346 ---EWRLGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAG 389
+W G+ L QF + + ++ + G Y+C + G
Sbjct: 486 KDGQWLQGDDL----QFKTMANGTLYIANVQEMDMGFYSCVAKSSTG 528
Score = 80.5 bits (197), Expect = 5e-15
Identities = 99/413 (23%), Positives = 159/413 (38%), Gaps = 63/413 (15%)
Query: 5 RLSNKTASPSIKLLVDDP--IVVNPGEAITLVCVTTGGEPAPSLTWVRS---FGTLPE-- 57
R+ + A P I V+ P ++V+ GE TL C G P P++ W ++ T+ E
Sbjct: 56 RVGPEDAMPRI---VEQPPDLLVSRGEPATLPC-RAEGRPRPNIEWYKNGARVATVREDP 111
Query: 58 ---KTVLNGGTLTIPAITSD-----DAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWI 109
+ +L G L P I D G Y+C+A N +G A ++ ++ V L+
Sbjct: 112 RAHRLLLPSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLR------ 165
Query: 110 TPDPYHKDDN---IQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDV 166
D + + + +G + C V E + SW K+G L+ E + + +
Sbjct: 166 --DDFRQSPGNVVVAVGEPAVLEC-VPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLM 222
Query: 167 SPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVT 226
T +D G Y CVAS G + +V + P L P + V
Sbjct: 223 MSHTLK--------SDAGMYVCVASNMAGERESAAAEVMVLER--PSFLRRPVNQ---VV 269
Query: 227 REGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRC 286
+ C+V G P P + W + D E +P G ++ S D +L I +VS E G Y C
Sbjct: 270 LADAPVTFLCEVKGDPPPRLRWRKEDGE--LPTGRYEIRS-DHSLWIGHVSAEDEGTYTC 326
Query: 287 QTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYE 346
+V EA L V PP + + SV C P +
Sbjct: 327 VAEN----SVGRAEASGSLSVHVPPQLVTQPQDQMAAPGESVAFQCETKGNPPPAIF--- 379
Query: 347 WRL---------GNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGA 390
W+ L TG+F + + ++ + G Y C ++ AG+
Sbjct: 380 WQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGS 432
Score = 50.8 bits (120), Expect = 4e-06
Identities = 67/287 (23%), Positives = 107/287 (37%), Gaps = 41/287 (14%)
Query: 123 GREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDV------SPGTTNLDII 176
G + C+ E P + W+KNG R+ + DP S I+
Sbjct: 78 GEPATLPCRAEGRPRPNI--EWYKNGA------RVATVREDPRAHRLLLPSGALFFPRIV 129
Query: 177 DLKFT--DFGTYTCVAS--LKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTI 232
+ D G YTCVA L + S++V + Q +V G+
Sbjct: 130 HGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFR------QSPGNVVVAVGEPA 183
Query: 233 ELQC-QVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQY 291
L+C G P+P + W + + +G + + G L + + + +GMY C S
Sbjct: 184 VLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRG--GKLMMSHTLKSDAGMYVCVASNM 241
Query: 292 NGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQ----DRSVTMSCRVLRAYPIRVLTYEW 347
G + A +++V P+FL Q D VT C V P R+ W
Sbjct: 242 AG---ERESAAAEVMV----LERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRL---RW 291
Query: 348 RLGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCS 394
R + L TG+++ + + +S E+ G Y C N G S
Sbjct: 292 RKEDGELPTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEAS 338
Score = 33.1 bits (74), Expect = 0.94
Identities = 35/154 (22%), Positives = 62/154 (40%), Gaps = 25/154 (16%)
Query: 203 DVNISSSTVPPNLTVPQ--EKSP-LVTREGDTIELQCQVTGKPKPIILWSRADKEVA--- 256
D +++ S V P +P+ E+ P L+ G+ L C+ G+P+P I W + VA
Sbjct: 49 DPSLNGSRVGPEDAMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVR 108
Query: 257 ---------MPDGSMQMESYDGTLRIVN--VSREMSGMYRCQTSQYNGFNVKPREALVQL 305
+P G++ RIV+ +R G+Y C Y G +L
Sbjct: 109 EDPRAHRLLLPSGALFFP------RIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVA 162
Query: 306 IVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYP 339
+++ P + + G+ + C R +P
Sbjct: 163 VLRDDFRQSPGNVVVAVGE--PAVLECVPPRGHP 194
>gi|134244585 putative neuronal cell adhesion molecule [Homo
sapiens]
Length = 814
Score = 90.5 bits (223), Expect = 5e-18
Identities = 99/394 (25%), Positives = 159/394 (40%), Gaps = 48/394 (12%)
Query: 24 VVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKT---VLNGGTLTI------PAITSD 74
V PG+ I L C G P +TW ++ LPE T +L G+L I P +
Sbjct: 52 VAVPGQPIVLDCRVEGTPPV-RITWRKNGVELPESTHSTLLANGSLMIRHFRLEPGGSPS 110
Query: 75 DAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGRE---VKISCQ 131
D G Y C+A N G + I T +H +G E + CQ
Sbjct: 111 DEGDYECVAQNRFGLVVSRKARIQAA---------TMSDFHVHPQATVGEEGGVARFQCQ 161
Query: 132 VEAVPSEELTFSWFKNGRPLRS-SERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVA 190
+ +P +T W KN P+ + +ER + L I L+ D G + CVA
Sbjct: 162 IHGLPKPLIT--WEKNRVPIDTDNERYTLLPKGV--------LQITGLRAEDGGIFHCVA 211
Query: 191 S----LKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPII 246
S ++ + +++ + S + P + V E L + T L+C TG P+PI+
Sbjct: 212 SNIASIRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQ--TAVLECVATGNPRPIV 269
Query: 247 LWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLI 306
WSR D +G + + G L I +V+ + SG+Y C ++ G V+ R A +L+
Sbjct: 270 SWSRLDGRPIGVEGIQVLGT--GNLIISDVTVQHSGVYVCAANR-PGTRVR-RTAQGRLV 325
Query: 307 VQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFD--SQEY 364
VQ P I + + +C+ P V W ++L G
Sbjct: 326 VQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHV---TWLKNGQVLGPGGHVRLKNNN 382
Query: 365 TEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVT 398
+ + + E+ +Y C N AG+ + S +T
Sbjct: 383 STLTISGIGPEDEAIYQCVAENSAGSSQASARLT 416
Score = 66.6 bits (161), Expect = 8e-11
Identities = 102/488 (20%), Positives = 181/488 (37%), Gaps = 64/488 (13%)
Query: 40 GEPAPSLTWVRS---FGTLPEK-TVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKST 95
G P P +TW ++ T E+ T+L G L I + ++D G + C+A+N
Sbjct: 164 GLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRISHGA 223
Query: 96 NIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFK-NGRPLRSS 154
+ V G + P +N+ + + A + SW + +GRP+
Sbjct: 224 RLTVSGSGSGAYK-EPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGVE 282
Query: 155 ERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPN 214
V+ GT NL I D+ G Y C A+ G + + V
Sbjct: 283 GIQVL---------GTGNLIISDVTVQHSGVYVCAANRPGTRVRRTAQ----GRLVVQAP 329
Query: 215 LTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIV 274
Q + G T CQ G+P P + W + + +V P G +++++ + TL I
Sbjct: 330 AEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLK-NGQVLGPGGHVRLKNNNSTLTIS 388
Query: 275 NVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQY------PP----AVEPAFLEIRQGQ 324
+ E +Y+C G + +A +L V + PP AV + E+R
Sbjct: 389 GIGPEDEAIYQCVAENSAGSS----QASARLTVLWAEGLPGPPRNVRAVSVSSTEVRVSW 444
Query: 325 DRSVTMSCRVLRAYPIRV--------LTYEWRLGNKLLRTGQFDSQEYTEYAVKSLSNEN 376
+ + ++ Y + + L Y+ + + D + T Y+ +
Sbjct: 445 SEPLANTKEII-GYVLHIRKAADPPELEYQEAVSKSTFQHLVSDLEPSTAYSFYIKAYTP 503
Query: 377 YGVYNCSIINEAGAGRCSFLVTGKAYAPEFYYDTYNPVWQNRHRVYSYSLQWTQMNPDAV 436
G + S+ A G+A AP P+ S L W P
Sbjct: 504 RGASSASVPTLAST-------LGEAPAPP-------PLSVRVLGSSSLQLLWEPW-PRLA 548
Query: 437 DRIVAYRLGIRQAGQQRWWEQEIKINGNIQKGELITYNLTELIKPEAYEVRLTPLTKFGE 496
++L R A + + + G + +YNL++L YEV+L + G+
Sbjct: 549 QHEGGFKLFYRPASKTSF------TGPILLPGTVSSYNLSQLDPTAVYEVKLLAYNQHGD 602
Query: 497 GDSTIRVI 504
G++T+R +
Sbjct: 603 GNATVRFV 610
Score = 55.5 bits (132), Expect = 2e-07
Identities = 49/183 (26%), Positives = 73/183 (39%), Gaps = 30/183 (16%)
Query: 117 DDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVIT----------QTDPDV 166
DD G+ + + C+VE P +T W KNG L S + + +P
Sbjct: 50 DDVAVPGQPIVLDCRVEGTPPVRIT--WRKNGVELPESTHSTLLANGSLMIRHFRLEPGG 107
Query: 167 SPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVT 226
SP +D G Y CVA + G + +S I ++T+ PQ V
Sbjct: 108 SP------------SDEGDYECVAQNRFGLV--VSRKARIQAATMSDFHVHPQAT---VG 150
Query: 227 REGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRC 286
EG QCQ+ G PKP+I W + ++ D G L+I + E G++ C
Sbjct: 151 EEGGVARFQCQIHGLPKPLITWEK-NRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHC 209
Query: 287 QTS 289
S
Sbjct: 210 VAS 212
Score = 30.4 bits (67), Expect = 6.1
Identities = 43/180 (23%), Positives = 67/180 (37%), Gaps = 22/180 (12%)
Query: 220 EKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSRE 279
E S V G I L C+V G P I W + V +P+ + +G+L I + E
Sbjct: 47 EPSDDVAVPGQPIVLDCRVEGTPPVRITWRK--NGVELPESTHSTLLANGSLMIRHFRLE 104
Query: 280 MSGM------YRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCR 333
G Y C G V R+A +Q V P + G++ V
Sbjct: 105 PGGSPSDEGDYECVAQNRFGL-VVSRKARIQAATMSDFHVHP---QATVGEEGGVARFQC 160
Query: 334 VLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYT-----EYAVKSLSNENYGVYNCSIINEA 388
+ P ++T W + T D++ YT + L E+ G+++C N A
Sbjct: 161 QIHGLPKPLIT--WEKNRVPIDT---DNERYTLLPKGVLQITGLRAEDGGIFHCVASNIA 215
>gi|19743806 roundabout 1 isoform b [Homo sapiens]
Length = 1612
Score = 90.1 bits (222), Expect = 6e-18
Identities = 102/370 (27%), Positives = 146/370 (39%), Gaps = 57/370 (15%)
Query: 11 ASPSIKLLVDD------PIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKT---VL 61
AS + +L DD ++V GE + C G P P+++W + L +K +
Sbjct: 122 ASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITI 181
Query: 62 NGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQ 121
GG L I DAG Y C+ N VG + + V L++ F P + +
Sbjct: 182 RGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTV--LERPSF--VKRPSNLAVTVD 237
Query: 122 IGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFT 181
E K + + VP T W K+ L S + L I +
Sbjct: 238 DSAEFKCEARGDPVP----TVRWRKDDGELPKSRYEIRDDH---------TLKIRKVTAG 284
Query: 182 DFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTV-PQEKSPLVTREGDTIELQCQVTG 240
D G+YTCVA G ++ S + + PP+ V P+++ V G T+ QC+ TG
Sbjct: 285 DMGSYTCVAENMVGK-AEASATLTVQE---PPHFVVKPRDQ---VVALGRTVTFQCEATG 337
Query: 241 KPKPIILWSRADKEVAM-----PDGSMQME-SYDGTLRIVNVSREMSGMYRCQTSQYNGF 294
P+P I W R + + P S + S G L I NV R G Y CQT G
Sbjct: 338 NPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGS 397
Query: 295 NV-KPREALVQLIVQYPPAVEPAFLEIRQGQ-------DRSVTMSCRVLRAYPIRVLTYE 346
+ K + +I PP V IRQG D + +SC V P V T
Sbjct: 398 IITKAYLEVTDVIADRPPPV------IRQGPVNQTVAVDGTFVLSC-VATGSP--VPTIL 448
Query: 347 WRLGNKLLRT 356
WR L+ T
Sbjct: 449 WRKDGVLVST 458
Score = 84.7 bits (208), Expect = 3e-16
Identities = 74/267 (27%), Positives = 121/267 (45%), Gaps = 34/267 (12%)
Query: 40 GEPAPSLTWVRSFGTLPEKT--VLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNI 97
G+P P++ W + G LP+ + + TL I +T+ D G+Y+C+A N VG A+ S +
Sbjct: 248 GDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGK-AEASATL 306
Query: 98 IVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVP----------SEELTFSWFKN 147
V+ + F + P +D + +GR V C+ P S+ L FS+
Sbjct: 307 TVQ--EPPHFVVKP----RDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSY--- 357
Query: 148 GRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTC-VASLKGGGISDISIDVNI 206
+P +SS R ++QT +L I +++ +D G Y C ++ G I+ ++V
Sbjct: 358 -QPPQSSSRFSVSQTG--------DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTD 408
Query: 207 SSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMES 266
+ PP + + V +G T L C TG P P ILW R D + S +
Sbjct: 409 VIADRPPPVIRQGPVNQTVAVDG-TFVLSCVATGSPVPTILW-RKDGVLVSTQDSRIKQL 466
Query: 267 YDGTLRIVNVSREMSGMYRCQTSQYNG 293
+G L+I +G Y C S +G
Sbjct: 467 ENGVLQIRYAKLGDTGRYTCIASTPSG 493
Score = 82.4 bits (202), Expect = 1e-15
Identities = 94/397 (23%), Positives = 154/397 (38%), Gaps = 54/397 (13%)
Query: 18 LVDDP--IVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLP--------EKTVLNGGTLT 67
+V+ P ++V+ GE TL C G P P++ W + + + +L G+L
Sbjct: 31 IVEHPSDLIVSKGEPATLNCKAEG-RPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLF 89
Query: 68 IPAI-----TSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQI 122
I + D G Y C+A N +G + ++ V A+ + F P D + +
Sbjct: 90 FLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEV-AILRDDFRQNP----SDVMVAV 144
Query: 123 GREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTD 182
G + CQ E T SW K+G PL + + + L I + +D
Sbjct: 145 GEPAVMECQPPR-GHPEPTISWKKDGSPLDDKDERITIRGG--------KLMITYTRKSD 195
Query: 183 FGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKP 242
G Y CV + G + ++ TV + + S L D+ E +C+ G P
Sbjct: 196 AGKYVCVGTNMVG-----ERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDP 250
Query: 243 KPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREAL 302
P + W + D E +P ++ D TL+I V+ G Y C G EA
Sbjct: 251 VPTVRWRKDDGE--LPKSRYEIRD-DHTLKIRKVTAGDMGSYTCVAENMVG----KAEAS 303
Query: 303 VQLIVQYPP--AVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLL------ 354
L VQ PP V+P + G R+VT C P + + LL
Sbjct: 304 ATLTVQEPPHFVVKPRDQVVALG--RTVTFQCEA-TGNPQPAIFWRREGSQNLLFSYQPP 360
Query: 355 -RTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGA 390
+ +F + + + ++ + G Y C +N AG+
Sbjct: 361 QSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGS 397
Score = 43.9 bits (102), Expect = 5e-04
Identities = 62/287 (21%), Positives = 110/287 (38%), Gaps = 33/287 (11%)
Query: 123 GREVKISCQVEAVPSEELTFSWFKNGRPLRS------SERMVITQTDPDVSPGTTNLDII 176
G ++C+ E P+ T W+K G + + S RM++ S L I+
Sbjct: 43 GEPATLNCKAEGRPTP--TIEWYKGGERVETDKDDPRSHRMLLP------SGSLFFLRIV 94
Query: 177 DLKFT--DFGTYTCVA-SLKGGGIS-DISIDVNISSSTVPPNLTVPQEKSPLVTREGDTI 232
+ + D G Y CVA + G +S + S++V I N S ++ G+
Sbjct: 95 HGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQN------PSDVMVAVGEPA 148
Query: 233 ELQCQVT-GKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQY 291
++CQ G P+P I W + + D + + G L I + +G Y C +
Sbjct: 149 VMECQPPRGHPEPTISWKKDGSPLDDKDERITIRG--GKLMITYTRKSDAGKYVCVGTNM 206
Query: 292 NGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGN 351
G + + +L V P+ + D S C R P+ T WR +
Sbjct: 207 VG---ERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEA-RGDPVP--TVRWRKDD 260
Query: 352 KLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVT 398
L +++ ++ ++ ++ + G Y C N G S +T
Sbjct: 261 GELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLT 307
Score = 40.8 bits (94), Expect = 0.004
Identities = 36/149 (24%), Positives = 62/149 (41%), Gaps = 24/149 (16%)
Query: 212 PPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEV------------AMPD 259
PP + + S L+ +G+ L C+ G+P P I W + + V +P
Sbjct: 28 PPRIV--EHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 85
Query: 260 GSMQMESYDGTLRIVN--VSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAF 317
GS+ LRIV+ SR G+Y C Y G V +L I++ P+
Sbjct: 86 GSLFF------LRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSD 139
Query: 318 LEIRQGQDRSVTMSCRVLRAYPIRVLTYE 346
+ + G+ M C+ R +P ++++
Sbjct: 140 VMVAVGE--PAVMECQPPRGHPEPTISWK 166
>gi|4506569 roundabout 1 isoform a [Homo sapiens]
Length = 1651
Score = 90.1 bits (222), Expect = 6e-18
Identities = 102/370 (27%), Positives = 146/370 (39%), Gaps = 57/370 (15%)
Query: 11 ASPSIKLLVDD------PIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKT---VL 61
AS + +L DD ++V GE + C G P P+++W + L +K +
Sbjct: 161 ASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITI 220
Query: 62 NGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQ 121
GG L I DAG Y C+ N VG + + V L++ F P + +
Sbjct: 221 RGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTV--LERPSF--VKRPSNLAVTVD 276
Query: 122 IGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFT 181
E K + + VP T W K+ L S + L I +
Sbjct: 277 DSAEFKCEARGDPVP----TVRWRKDDGELPKSRYEIRDDH---------TLKIRKVTAG 323
Query: 182 DFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTV-PQEKSPLVTREGDTIELQCQVTG 240
D G+YTCVA G ++ S + + PP+ V P+++ V G T+ QC+ TG
Sbjct: 324 DMGSYTCVAENMVGK-AEASATLTVQE---PPHFVVKPRDQ---VVALGRTVTFQCEATG 376
Query: 241 KPKPIILWSRADKEVAM-----PDGSMQME-SYDGTLRIVNVSREMSGMYRCQTSQYNGF 294
P+P I W R + + P S + S G L I NV R G Y CQT G
Sbjct: 377 NPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGS 436
Query: 295 NV-KPREALVQLIVQYPPAVEPAFLEIRQGQ-------DRSVTMSCRVLRAYPIRVLTYE 346
+ K + +I PP V IRQG D + +SC V P V T
Sbjct: 437 IITKAYLEVTDVIADRPPPV------IRQGPVNQTVAVDGTFVLSC-VATGSP--VPTIL 487
Query: 347 WRLGNKLLRT 356
WR L+ T
Sbjct: 488 WRKDGVLVST 497
Score = 84.7 bits (208), Expect = 3e-16
Identities = 74/267 (27%), Positives = 121/267 (45%), Gaps = 34/267 (12%)
Query: 40 GEPAPSLTWVRSFGTLPEKT--VLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNI 97
G+P P++ W + G LP+ + + TL I +T+ D G+Y+C+A N VG A+ S +
Sbjct: 287 GDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGK-AEASATL 345
Query: 98 IVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVP----------SEELTFSWFKN 147
V+ + F + P +D + +GR V C+ P S+ L FS+
Sbjct: 346 TVQ--EPPHFVVKP----RDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSY--- 396
Query: 148 GRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTC-VASLKGGGISDISIDVNI 206
+P +SS R ++QT +L I +++ +D G Y C ++ G I+ ++V
Sbjct: 397 -QPPQSSSRFSVSQTG--------DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTD 447
Query: 207 SSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMES 266
+ PP + + V +G T L C TG P P ILW R D + S +
Sbjct: 448 VIADRPPPVIRQGPVNQTVAVDG-TFVLSCVATGSPVPTILW-RKDGVLVSTQDSRIKQL 505
Query: 267 YDGTLRIVNVSREMSGMYRCQTSQYNG 293
+G L+I +G Y C S +G
Sbjct: 506 ENGVLQIRYAKLGDTGRYTCIASTPSG 532
Score = 82.4 bits (202), Expect = 1e-15
Identities = 94/397 (23%), Positives = 154/397 (38%), Gaps = 54/397 (13%)
Query: 18 LVDDP--IVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLP--------EKTVLNGGTLT 67
+V+ P ++V+ GE TL C G P P++ W + + + +L G+L
Sbjct: 70 IVEHPSDLIVSKGEPATLNCKAEG-RPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLF 128
Query: 68 IPAI-----TSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQI 122
I + D G Y C+A N +G + ++ V A+ + F P D + +
Sbjct: 129 FLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEV-AILRDDFRQNP----SDVMVAV 183
Query: 123 GREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTD 182
G + CQ E T SW K+G PL + + + L I + +D
Sbjct: 184 GEPAVMECQPPR-GHPEPTISWKKDGSPLDDKDERITIRGG--------KLMITYTRKSD 234
Query: 183 FGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKP 242
G Y CV + G + ++ TV + + S L D+ E +C+ G P
Sbjct: 235 AGKYVCVGTNMVG-----ERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDP 289
Query: 243 KPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREAL 302
P + W + D E +P ++ D TL+I V+ G Y C G EA
Sbjct: 290 VPTVRWRKDDGE--LPKSRYEIRD-DHTLKIRKVTAGDMGSYTCVAENMVG----KAEAS 342
Query: 303 VQLIVQYPP--AVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLL------ 354
L VQ PP V+P + G R+VT C P + + LL
Sbjct: 343 ATLTVQEPPHFVVKPRDQVVALG--RTVTFQCEA-TGNPQPAIFWRREGSQNLLFSYQPP 399
Query: 355 -RTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGA 390
+ +F + + + ++ + G Y C +N AG+
Sbjct: 400 QSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGS 436
Score = 43.9 bits (102), Expect = 5e-04
Identities = 62/287 (21%), Positives = 110/287 (38%), Gaps = 33/287 (11%)
Query: 123 GREVKISCQVEAVPSEELTFSWFKNGRPLRS------SERMVITQTDPDVSPGTTNLDII 176
G ++C+ E P+ T W+K G + + S RM++ S L I+
Sbjct: 82 GEPATLNCKAEGRPTP--TIEWYKGGERVETDKDDPRSHRMLLP------SGSLFFLRIV 133
Query: 177 DLKFT--DFGTYTCVA-SLKGGGIS-DISIDVNISSSTVPPNLTVPQEKSPLVTREGDTI 232
+ + D G Y CVA + G +S + S++V I N S ++ G+
Sbjct: 134 HGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQN------PSDVMVAVGEPA 187
Query: 233 ELQCQVT-GKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQY 291
++CQ G P+P I W + + D + + G L I + +G Y C +
Sbjct: 188 VMECQPPRGHPEPTISWKKDGSPLDDKDERITIRG--GKLMITYTRKSDAGKYVCVGTNM 245
Query: 292 NGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGN 351
G + + +L V P+ + D S C R P+ T WR +
Sbjct: 246 VG---ERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEA-RGDPVP--TVRWRKDD 299
Query: 352 KLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVT 398
L +++ ++ ++ ++ + G Y C N G S +T
Sbjct: 300 GELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLT 346
Score = 40.8 bits (94), Expect = 0.004
Identities = 36/149 (24%), Positives = 62/149 (41%), Gaps = 24/149 (16%)
Query: 212 PPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEV------------AMPD 259
PP + + S L+ +G+ L C+ G+P P I W + + V +P
Sbjct: 67 PPRIV--EHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 124
Query: 260 GSMQMESYDGTLRIVN--VSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAF 317
GS+ LRIV+ SR G+Y C Y G V +L I++ P+
Sbjct: 125 GSLFF------LRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSD 178
Query: 318 LEIRQGQDRSVTMSCRVLRAYPIRVLTYE 346
+ + G+ M C+ R +P ++++
Sbjct: 179 VMVAVGE--PAVMECQPPRGHPEPTISWK 205
>gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]
Length = 1215
Score = 89.7 bits (221), Expect = 8e-18
Identities = 101/404 (25%), Positives = 161/404 (39%), Gaps = 51/404 (12%)
Query: 13 PSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKT----VLNGGTLTI 68
P +L+ + V+PGE L C G P +LTWVR + LP T L +L I
Sbjct: 399 PPPQLVPAPNVTVSPGETAVLSCRVLGEAPY-NLTWVRDWRVLPASTGRVAQLADLSLEI 457
Query: 69 PAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKI 128
I D G Y C+A+N G + S ++VR + + + G EVK+
Sbjct: 458 SGIIPTDGGRYQCVASNANG-VTRASVWLLVREAPQVSI------HTSSQHFSQGVEVKV 510
Query: 129 SCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTC 188
SC P+ + SW + + L+ R+ + + GT L I + D G Y+C
Sbjct: 511 SCSASGYPTPHI--SWSRESQALQEDSRIHVD------AQGT--LIIQGVAPEDAGNYSC 560
Query: 189 VASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILW 248
A+ +++ D + +V + ++ G+ L C+ +G P P ++W
Sbjct: 561 QAT------NEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIW 614
Query: 249 SRADKEVAM-PDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIV 307
R E+ + P+GS G LRI +G Y C+ G A +QL V
Sbjct: 615 YRGGLEMILAPEGSS-----SGKLRIPAAQERDAGTYTCRAVNELG----DASAEIQLAV 665
Query: 308 QYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGN-----KLLRTGQFDSQ 362
+ P + ++ RS ++CR P T WR G+ L G+
Sbjct: 666 GHAPQLTELPRDVTVELGRSALLACRATGRPP---PTVTWRRGDGQPLGLRLGAGRGSRS 722
Query: 363 EYTEYAV---KSLSNENYGVYNCSIINEAG--AGRCSFLVTGKA 401
+ V +S++ E+ Y C N G +VTG A
Sbjct: 723 RQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHA 766
Score = 89.4 bits (220), Expect = 1e-17
Identities = 91/374 (24%), Positives = 151/374 (40%), Gaps = 54/374 (14%)
Query: 34 VCVTTGGEPAPSLTWVRSFGTLPEKTVLN---GGTLTIPAITSDDAGTYSCIANNNVGNP 90
V + G P P ++W R L E + ++ GTL I + +DAG YSC A N VG
Sbjct: 510 VSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTD 569
Query: 91 AKKSTNIIVRALKKGRFWITPDPYHKDDN----IQIGREVKISCQVEAVPSEELTFSWFK 146
+ T + T P N + +G E + C+ VP + W++
Sbjct: 570 QETVT-----------LYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVI--WYR 616
Query: 147 NGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNI 206
G M++ P+ S + L I + D GTYTC A + D S ++ +
Sbjct: 617 GGL------EMILA---PEGS-SSGKLRIPAAQERDAGTYTCRAV---NELGDASAEIQL 663
Query: 207 SSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKE-----VAMPDGS 261
+ P +P++ + G + L C+ TG+P P + W R D + + GS
Sbjct: 664 AVGHAPQLTELPRD---VTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGS 720
Query: 262 MQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIR 321
+ G L +V+ E Y C+ N F EA + + PP + + +R
Sbjct: 721 RSRQPDSGVLFFESVAPEDQAPYVCEAR--NVFGKVQAEARLIVTGHAPPQIASSAPTVR 778
Query: 322 QGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTG-----QFDSQEYTEYAVKSLSNEN 376
+ + V++ C VL P+ W + L G + D + + A++ E+
Sbjct: 779 VLEGQPVSLPCIVLAGRPLP--ERHWLKDGRPLPPGSRHSIRADGSLHLDRALQ----EH 832
Query: 377 YGVYNCSIINEAGA 390
G Y+C N AG+
Sbjct: 833 AGRYSCVATNTAGS 846
Score = 81.6 bits (200), Expect = 2e-15
Identities = 95/386 (24%), Positives = 158/386 (40%), Gaps = 33/386 (8%)
Query: 10 TASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTL---PEKTVLNGGTL 66
T PS+ V+ ++V GE LVC +G P P + W R + PE + + G L
Sbjct: 578 TDPPSVSA-VNAVVLVAVGEEAVLVCEASG-VPPPRVIWYRGGLEMILAPEGS--SSGKL 633
Query: 67 TIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREV 126
IPA DAGTY+C A N +G+ + + + A + +T P +D +++GR
Sbjct: 634 RIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQ-----LTELP--RDVTVELGRSA 686
Query: 127 KISCQVEAVPSEELTFSWFK-NGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGT 185
++C+ P +T W + +G+PL R+ + P + L + D
Sbjct: 687 LLACRATGRPPPTVT--WRRGDGQPL--GLRLGAGRGSRSRQPDSGVLFFESVAPEDQAP 742
Query: 186 YTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLV-TREGDTIELQCQV-TGKPK 243
Y C A G + + I + PP + +P V EG + L C V G+P
Sbjct: 743 YVCEARNVFGKVQAEAR--LIVTGHAPPQIA---SSAPTVRVLEGQPVSLPCIVLAGRPL 797
Query: 244 PIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALV 303
P W + + +P GS DG+L + +E +G Y C + G + V
Sbjct: 798 PERHWLKDGRP--LPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRD----V 851
Query: 304 QLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQE 363
+L+VQ PP + P + ++ C V P +T+ R ++ +
Sbjct: 852 ELVVQVPPRIHPTATHHITNEGVPASLPC-VASGVPAPTITWTKETNALTSRGPHYNVSK 910
Query: 364 YTEYAVKSLSNENYGVYNCSIINEAG 389
+ S ++ G Y C+ N G
Sbjct: 911 EGTLLIAQPSAQDAGAYVCTATNTVG 936
Score = 75.1 bits (183), Expect = 2e-13
Identities = 73/296 (24%), Positives = 121/296 (40%), Gaps = 45/296 (15%)
Query: 10 TASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLP---EKTVLNGGTL 66
+++P++++L G+ ++L C+ G P P W++ LP ++ G+L
Sbjct: 772 SSAPTVRVL--------EGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSL 823
Query: 67 TIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREV 126
+ + AG YSC+A N G+ + ++V+ + I P H N G
Sbjct: 824 HLDRALQEHAGRYSCVATNTAGSQ-HRDVELVVQVPPR----IHPTATHHITNE--GVPA 876
Query: 127 KISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDP--DVSPGTTNLDIIDLKFTDFG 184
+ C VP+ +T W K E +T P +VS T L I D G
Sbjct: 877 SLPCVASGVPAPTIT--WTK--------ETNALTSRGPHYNVSKEGTLL-IAQPSAQDAG 925
Query: 185 TYTCVASLKGGGISDISIDVNISSSTVPP-------NLTVPQEKSPLVTREGDTIELQCQ 237
Y C A+ G S ++ +S +T P N VP + + + G+ + L C+
Sbjct: 926 AYVCTATNTVGFSSQ---EMRLSVNTKPRIHMNGSRNANVPLQ---VTAKAGEEVTLDCE 979
Query: 238 VTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNG 293
G P P++ W++ D P + G+LR+ V SG Y C S G
Sbjct: 980 AKGSPPPLVTWTK-DSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAG 1034
Score = 72.8 bits (177), Expect = 1e-12
Identities = 76/315 (24%), Positives = 124/315 (39%), Gaps = 32/315 (10%)
Query: 75 DAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEA 134
+ GTY C A + G K+ ++ + + P P + + G +SC+V
Sbjct: 373 EEGTYECTAVSRAGTGRAKAQIVVTDPPPQ----LVPAP---NVTVSPGETAVLSCRVLG 425
Query: 135 VPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKG 194
LT W ++ R L +S V D +L+I + TD G Y CVAS
Sbjct: 426 EAPYNLT--WVRDWRVLPASTGRVAQLAD-------LSLEISGIIPTDGGRYQCVAS-NA 475
Query: 195 GGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKE 254
G++ S+ + + + T Q S +G +++ C +G P P I WSR + +
Sbjct: 476 NGVTRASVWLLVREAPQVSIHTSSQHFS-----QGVEVKVSCSASGYPTPHISWSR-ESQ 529
Query: 255 VAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVE 314
D + +++ GTL I V+ E +G Y CQ + G + + V L PP+V
Sbjct: 530 ALQEDSRIHVDA-QGTLIIQGVAPEDAGNYSCQATNEVGTD----QETVTLYYTDPPSVS 584
Query: 315 PAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAVKSLSN 374
+ + C P RV+ Y L L G + + +
Sbjct: 585 AVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSG----KLRIPAAQE 640
Query: 375 ENYGVYNCSIINEAG 389
+ G Y C +NE G
Sbjct: 641 RDAGTYTCRAVNELG 655
Score = 62.8 bits (151), Expect = 1e-09
Identities = 76/302 (25%), Positives = 113/302 (37%), Gaps = 53/302 (17%)
Query: 23 IVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTL----------PEKTVLNGGTLTIPAIT 72
+ V G + L C TG P P++TW R G + G L ++
Sbjct: 678 VTVELGRSALLACRATG-RPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVA 736
Query: 73 SDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQI--GREVKISC 130
+D Y C A N G ++ I+ P +++ G+ V + C
Sbjct: 737 PEDQAPYVCEARNVFGKVQAEARLIVTGHAP-------PQIASSAPTVRVLEGQPVSLPC 789
Query: 131 QVEA---VPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYT 187
V A +P W K+GRPL R I + G+ +LD + G Y+
Sbjct: 790 IVLAGRPLPERH----WLKDGRPLPPGSRHSIR------ADGSLHLDRALQEHA--GRYS 837
Query: 188 CVASLKGGGIS-DISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPII 246
CVA+ G D+ + V VPP + + +T EG L C +G P P I
Sbjct: 838 CVATNTAGSQHRDVELVVQ-----VPPR--IHPTATHHITNEGVPASLPCVASGVPAPTI 890
Query: 247 LWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGF---------NVK 297
W++ + G S +GTL I S + +G Y C + GF N K
Sbjct: 891 TWTK-ETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTK 949
Query: 298 PR 299
PR
Sbjct: 950 PR 951
Score = 62.0 bits (149), Expect = 2e-09
Identities = 61/215 (28%), Positives = 91/215 (42%), Gaps = 33/215 (15%)
Query: 24 VVNPGEAITLVCVTTGGEPAPSLTWVRSFGTL----PEKTVLNGGTLTIPAITSDDAGTY 79
+ N G +L CV +G PAP++TW + L P V GTL I ++ DAG Y
Sbjct: 869 ITNEGVPASLPCVASG-VPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAY 927
Query: 80 SCIANNNVGNPAKK---STNIIVRALKKGRFWITPDPYHKDDNIQI------GREVKISC 130
C A N VG +++ S N R G ++ N+ + G EV + C
Sbjct: 928 VCTATNTVGFSSQEMRLSVNTKPRIHMNG---------SRNANVPLQVTAKAGEEVTLDC 978
Query: 131 QVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVA 190
+ + P +T W K+ RP+ IT + G +L + ++ D G Y C A
Sbjct: 979 EAKGSPPPLVT--WTKDSRPVPP-----ITNRYGLLPSG--SLRLAQVQVGDSGHYECTA 1029
Query: 191 SLKGGGISD-ISIDVNISSSTVPPNLTVPQEKSPL 224
S G S + V +S P +L VP + L
Sbjct: 1030 SNPAGSASHRYVLGVQGRTSWQPQSLPVPHHPACL 1064
Score = 54.7 bits (130), Expect = 3e-07
Identities = 87/381 (22%), Positives = 140/381 (36%), Gaps = 43/381 (11%)
Query: 15 IKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLNGGTLTI----PA 70
I L+++ + PG ++ + G+P TLP K + NG T + P
Sbjct: 224 ISLVINSTGLKAPGRLDSVELAQSSGKPLL---------TLPTKPLSNGSTHQLWGGPPF 274
Query: 71 ITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISC 130
T + ++ GNP + + + + G ++ P + + + +SC
Sbjct: 275 HTPKERFYLKVKGKDHEGNPLLRVSGVSYSGVAPGAPLVSMAPRIHG---YLHQPLLVSC 331
Query: 131 QVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVA 190
V + L + G ER G ++ +I+ + GTY C A
Sbjct: 332 SVHSALPFRLQL---RRGEARLGEERHF-------QESGNSSWEILRASKAEEGTYECTA 381
Query: 191 -SLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVT-REGDTIELQCQVTGKPKPIILW 248
S G G + I V T PP VP +P VT G+T L C+V G+ + W
Sbjct: 382 VSRAGTGRAKAQIVV-----TDPPPQLVP---APNVTVSPGETAVLSCRVLGEAPYNLTW 433
Query: 249 SRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQ 308
R D V + D +L I + G Y+C S NG A V L+V+
Sbjct: 434 VR-DWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVT----RASVWLLVR 488
Query: 309 YPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYA 368
P V Q V +SC YP +++ R L +
Sbjct: 489 EAPQVSIHTSSQHFSQGVEVKVSCSA-SGYPTPHISWS-RESQALQEDSRIHVDAQGTLI 546
Query: 369 VKSLSNENYGVYNCSIINEAG 389
++ ++ E+ G Y+C NE G
Sbjct: 547 IQGVAPEDAGNYSCQATNEVG 567
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.135 0.411
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,772,796
Number of Sequences: 37866
Number of extensions: 1411521
Number of successful extensions: 7527
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 197
Number of HSP's successfully gapped in prelim test: 258
Number of HSP's that attempted gapping in prelim test: 3225
Number of HSP's gapped (non-prelim): 2455
length of query: 727
length of database: 18,247,518
effective HSP length: 110
effective length of query: 617
effective length of database: 14,082,258
effective search space: 8688753186
effective search space used: 8688753186
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.