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Search of human proteins with 38146012
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|38146012 tetratricopeptide repeat domain 8 isoform B [Homo
sapiens]
(505 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|38146012 tetratricopeptide repeat domain 8 isoform B [Homo sa... 1020 0.0
gi|53759120 tetratricopeptide repeat domain 8 isoform A [Homo sa... 1012 0.0
gi|38146008 tetratricopeptide repeat domain 8 isoform C [Homo sa... 946 0.0
gi|25952122 Bardet-Biedl syndrome 4 [Homo sapiens] 75 1e-13
gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens] 66 8e-11
gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens] 66 8e-11
gi|118766328 transmembrane and tetratricopeptide repeat containi... 57 5e-08
gi|118766330 transmembrane and tetratricopeptide repeat containi... 57 5e-08
gi|167466177 cell division cycle protein 27 isoform 1 [Homo sapi... 52 1e-06
gi|167466175 cell division cycle protein 27 isoform 2 [Homo sapi... 52 1e-06
gi|7661950 SH2 domain binding protein 1 [Homo sapiens] 52 2e-06
gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens] 50 5e-06
gi|83415184 transmembrane and tetratricopeptide repeat containin... 49 1e-05
gi|224809432 transmembrane and tetratricopeptide repeat containi... 47 4e-05
gi|7662078 tetratricopeptide repeat domain 37 [Homo sapiens] 45 1e-04
gi|170784869 tetratricopeptide repeat domain 13 isoform b [Homo ... 44 3e-04
gi|170784867 tetratricopeptide repeat domain 13 isoform a [Homo ... 44 3e-04
gi|28558993 intraflagellar transport 88 homolog isoform 1 [Homo ... 44 4e-04
gi|28329439 intraflagellar transport 88 homolog isoform 2 [Homo ... 44 4e-04
gi|189011544 ubiquitously transcribed tetratricopeptide repeat, ... 41 0.002
gi|33188431 tetratricopeptide repeat protein isoform 3 [Homo sap... 41 0.002
gi|33188429 tetratricopeptide repeat protein isoform 1 [Homo sap... 41 0.002
gi|33188427 tetratricopeptide repeat protein isoform 2 [Homo sap... 41 0.002
gi|60685231 tetratricopeptide repeat domain 7B [Homo sapiens] 40 0.006
gi|22749211 transmembrane and tetratricopeptide repeat containin... 39 0.011
gi|4507711 tetratricopeptide repeat domain 1 [Homo sapiens] 39 0.014
gi|34304360 nephrocystin 3 [Homo sapiens] 37 0.055
gi|118402596 cell division cycle protein 23 [Homo sapiens] 37 0.055
gi|40548372 tetratricopeptide repeat domain 15 [Homo sapiens] 36 0.094
gi|153082755 interferon-induced protein with tetratricopeptide r... 35 0.21
>gi|38146012 tetratricopeptide repeat domain 8 isoform B [Homo
sapiens]
Length = 505
Score = 1020 bits (2637), Expect = 0.0
Identities = 505/505 (100%), Positives = 505/505 (100%)
Query: 1 MSSEMEPLLLAWSYFRRRKFQLCADLCTQMLEKSPYDQAAWILKARALTEMVYIDEIDVD 60
MSSEMEPLLLAWSYFRRRKFQLCADLCTQMLEKSPYDQAAWILKARALTEMVYIDEIDVD
Sbjct: 1 MSSEMEPLLLAWSYFRRRKFQLCADLCTQMLEKSPYDQAAWILKARALTEMVYIDEIDVD 60
Query: 61 QEGIAEMMLDENAIAQVPRPGTSLKLPGTNQTGGPSQAVRPITQAGRPITGFLRPSTQSG 120
QEGIAEMMLDENAIAQVPRPGTSLKLPGTNQTGGPSQAVRPITQAGRPITGFLRPSTQSG
Sbjct: 61 QEGIAEMMLDENAIAQVPRPGTSLKLPGTNQTGGPSQAVRPITQAGRPITGFLRPSTQSG 120
Query: 121 RPGTMEQAIRTPRTAYTARPITSSSGRFVRLGTASMLTSPDGPFINLSRLNLTKYSQKPK 180
RPGTMEQAIRTPRTAYTARPITSSSGRFVRLGTASMLTSPDGPFINLSRLNLTKYSQKPK
Sbjct: 121 RPGTMEQAIRTPRTAYTARPITSSSGRFVRLGTASMLTSPDGPFINLSRLNLTKYSQKPK 180
Query: 181 LAKALFEYIFHHENDVKTALDLAALSTEHSQYKDWWWKVQIGKCYYRLGMYREAEKQFKS 240
LAKALFEYIFHHENDVKTALDLAALSTEHSQYKDWWWKVQIGKCYYRLGMYREAEKQFKS
Sbjct: 181 LAKALFEYIFHHENDVKTALDLAALSTEHSQYKDWWWKVQIGKCYYRLGMYREAEKQFKS 240
Query: 241 ALKQQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSS 300
ALKQQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSS
Sbjct: 241 ALKQQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSS 300
Query: 301 AAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLGLCC 360
AAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLGLCC
Sbjct: 301 AAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLGLCC 360
Query: 361 FYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNH 420
FYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNH
Sbjct: 361 FYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNH 420
Query: 421 AEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGDLQRSYVAAQK 480
AEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGDLQRSYVAAQK
Sbjct: 421 AEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGDLQRSYVAAQK 480
Query: 481 SEAAFPDHVDTQHLIKQLRQHFAML 505
SEAAFPDHVDTQHLIKQLRQHFAML
Sbjct: 481 SEAAFPDHVDTQHLIKQLRQHFAML 505
>gi|53759120 tetratricopeptide repeat domain 8 isoform A [Homo
sapiens]
Length = 515
Score = 1012 bits (2616), Expect = 0.0
Identities = 505/515 (98%), Positives = 505/515 (98%), Gaps = 10/515 (1%)
Query: 1 MSSEMEPLLLAWSYFRRRKFQLCADLCTQMLEKSPYDQ----------AAWILKARALTE 50
MSSEMEPLLLAWSYFRRRKFQLCADLCTQMLEKSPYDQ AAWILKARALTE
Sbjct: 1 MSSEMEPLLLAWSYFRRRKFQLCADLCTQMLEKSPYDQEPDPELPVHQAAWILKARALTE 60
Query: 51 MVYIDEIDVDQEGIAEMMLDENAIAQVPRPGTSLKLPGTNQTGGPSQAVRPITQAGRPIT 110
MVYIDEIDVDQEGIAEMMLDENAIAQVPRPGTSLKLPGTNQTGGPSQAVRPITQAGRPIT
Sbjct: 61 MVYIDEIDVDQEGIAEMMLDENAIAQVPRPGTSLKLPGTNQTGGPSQAVRPITQAGRPIT 120
Query: 111 GFLRPSTQSGRPGTMEQAIRTPRTAYTARPITSSSGRFVRLGTASMLTSPDGPFINLSRL 170
GFLRPSTQSGRPGTMEQAIRTPRTAYTARPITSSSGRFVRLGTASMLTSPDGPFINLSRL
Sbjct: 121 GFLRPSTQSGRPGTMEQAIRTPRTAYTARPITSSSGRFVRLGTASMLTSPDGPFINLSRL 180
Query: 171 NLTKYSQKPKLAKALFEYIFHHENDVKTALDLAALSTEHSQYKDWWWKVQIGKCYYRLGM 230
NLTKYSQKPKLAKALFEYIFHHENDVKTALDLAALSTEHSQYKDWWWKVQIGKCYYRLGM
Sbjct: 181 NLTKYSQKPKLAKALFEYIFHHENDVKTALDLAALSTEHSQYKDWWWKVQIGKCYYRLGM 240
Query: 231 YREAEKQFKSALKQQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIAR 290
YREAEKQFKSALKQQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIAR
Sbjct: 241 YREAEKQFKSALKQQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIAR 300
Query: 291 IYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNG 350
IYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNG
Sbjct: 301 IYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNG 360
Query: 351 QLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCF 410
QLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCF
Sbjct: 361 QLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCF 420
Query: 411 RLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGD 470
RLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGD
Sbjct: 421 RLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGD 480
Query: 471 LQRSYVAAQKSEAAFPDHVDTQHLIKQLRQHFAML 505
LQRSYVAAQKSEAAFPDHVDTQHLIKQLRQHFAML
Sbjct: 481 LQRSYVAAQKSEAAFPDHVDTQHLIKQLRQHFAML 515
>gi|38146008 tetratricopeptide repeat domain 8 isoform C [Homo
sapiens]
Length = 475
Score = 946 bits (2445), Expect = 0.0
Identities = 475/505 (94%), Positives = 475/505 (94%), Gaps = 30/505 (5%)
Query: 1 MSSEMEPLLLAWSYFRRRKFQLCADLCTQMLEKSPYDQAAWILKARALTEMVYIDEIDVD 60
MSSEMEPLLLAWSYFRRRKFQLCADLCTQMLEKSPYDQAAWILKARALTEMVYIDEIDVD
Sbjct: 1 MSSEMEPLLLAWSYFRRRKFQLCADLCTQMLEKSPYDQAAWILKARALTEMVYIDEIDVD 60
Query: 61 QEGIAEMMLDENAIAQVPRPGTSLKLPGTNQTGGPSQAVRPITQAGRPITGFLRPSTQSG 120
QEGIAEMMLDENAIAQVPRPGTSLKLPGTNQTGGPSQAVRPITQAGRPITGFLRPSTQSG
Sbjct: 61 QEGIAEMMLDENAIAQVPRPGTSLKLPGTNQTGGPSQAVRPITQAGRPITGFLRPSTQSG 120
Query: 121 RPGTMEQAIRTPRTAYTARPITSSSGRFVRLGTASMLTSPDGPFINLSRLNLTKYSQKPK 180
RPGTMEQAIRTPRTAYTARPITSSSGRFVRLGTA
Sbjct: 121 RPGTMEQAIRTPRTAYTARPITSSSGRFVRLGTA-------------------------- 154
Query: 181 LAKALFEYIFHHENDVKTALDLAALSTEHSQYKDWWWKVQIGKCYYRLGMYREAEKQFKS 240
LFEYIFHHENDVKTALDLAALSTEHSQYKDWWWKVQIGKCYYRLGMYREAEKQFKS
Sbjct: 155 ----LFEYIFHHENDVKTALDLAALSTEHSQYKDWWWKVQIGKCYYRLGMYREAEKQFKS 210
Query: 241 ALKQQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSS 300
ALKQQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSS
Sbjct: 211 ALKQQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSS 270
Query: 301 AAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLGLCC 360
AAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLGLCC
Sbjct: 271 AAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLGLCC 330
Query: 361 FYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNH 420
FYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNH
Sbjct: 331 FYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNH 390
Query: 421 AEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGDLQRSYVAAQK 480
AEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGDLQRSYVAAQK
Sbjct: 391 AEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGDLQRSYVAAQK 450
Query: 481 SEAAFPDHVDTQHLIKQLRQHFAML 505
SEAAFPDHVDTQHLIKQLRQHFAML
Sbjct: 451 SEAAFPDHVDTQHLIKQLRQHFAML 475
>gi|25952122 Bardet-Biedl syndrome 4 [Homo sapiens]
Length = 519
Score = 75.5 bits (184), Expect = 1e-13
Identities = 65/270 (24%), Positives = 115/270 (42%), Gaps = 3/270 (1%)
Query: 213 KDWWWKVQIGKCYYRLGMYREAEKQFKSALKQQEMVDTFLYLAKVYVSLDQPVTALNLFK 272
KDW +G CY L + +A+ Q +AL T++ L K+++ A+ ++K
Sbjct: 133 KDWEISHNLGVCYIYLKQFNKAQDQLHNALNLNRHDLTYIMLGKIHLLEGDLDKAIEVYK 192
Query: 273 QGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQP 332
+ ++ P LL + +Y ++ A E+ L D T+ +AI GS
Sbjct: 193 KAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDPTNYKAILAAGSMMQTHGDF 252
Query: 333 EIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYN 392
++AL YR + + L+NN+G+C F ++Y ++ +RA LA + + + YN
Sbjct: 253 DVALTKYRVVACAVPESPPLWNNIGMCFFGKKKYVAAISCLKRANYLAPFDWK---ILYN 309
Query: 393 LGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAP 452
LG V + + A A+ E Y LAV +E A+ A L
Sbjct: 310 LGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNLEDIENAKRAYAEAVHLDK 369
Query: 453 HMYEPHFNFATISDKIGDLQRSYVAAQKSE 482
+ N+A + G+ + + Q+ E
Sbjct: 370 CNPLVNLNYAVLLYNQGEKKNALAQYQEME 399
Score = 42.0 bits (97), Expect = 0.001
Identities = 44/246 (17%), Positives = 99/246 (40%), Gaps = 9/246 (3%)
Query: 242 LKQQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSA 301
L++Q + Y+ K Y + + QGL ++ V L I+ N+ +
Sbjct: 32 LEKQNWLIHLHYIRKDYEACKAVIKEQLQETQGLCEYAIYVQAL-----IFRLEGNIQES 86
Query: 302 AEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCF 361
E ++ + + + + F + + A+ Y ++ + ++ +NLG+C
Sbjct: 87 LELFQTCAVLSPQSADNLKQVARSLFLLGKHKAAIEVYNEAAKLNQKDWEISHNLGVCYI 146
Query: 362 YAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHA 421
Y +Q++ AL+L ++ + LG + + GD + A + ++ A+ + +
Sbjct: 147 YLKQFNKAQDQLHNALNLNRHDL----TYIMLGKIHLLEGDLDKAIEVYKKAVEFSPENT 202
Query: 422 EAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGDLQRSYVAAQKS 481
E L +L ++ G ++A L A + P Y+ ++ GD + +
Sbjct: 203 ELLTTLGLLYLQLGIYQKAFEHLGNALTYDPTNYKAILAAGSMMQTHGDFDVALTKYRVV 262
Query: 482 EAAFPD 487
A P+
Sbjct: 263 ACAVPE 268
>gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens]
Length = 1036
Score = 65.9 bits (159), Expect = 8e-11
Identities = 60/302 (19%), Positives = 121/302 (40%), Gaps = 32/302 (10%)
Query: 221 IGKCYYRLGMYREAEKQFKSALK-QQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFP 279
+G Y G +EA + ++ AL+ + + +D ++ LA V+ A+ + L P
Sbjct: 85 LGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNP 144
Query: 280 GEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFY 339
+ + + + + + A Y + ++ A + +G + +A+ +
Sbjct: 145 DLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHF 204
Query: 340 RRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEE----EAADVWYNLGH 395
+ + + + NLG A+ +D + ++ RALSL+ N A V+Y G
Sbjct: 205 EKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGL 264
Query: 396 VAVGI---------------------------GDTNLAHQCFRLALVNNNNHAEAYNNLA 428
+ + I G A C+ AL HA++ NNLA
Sbjct: 265 IDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLA 324
Query: 429 VLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGDLQRSYVAAQKSEAAFPDH 488
++ +G++E+A L + A + P H N A++ + G LQ + + +++ P
Sbjct: 325 NIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTF 384
Query: 489 VD 490
D
Sbjct: 385 AD 386
Score = 64.7 bits (156), Expect = 2e-10
Identities = 48/209 (22%), Positives = 94/209 (44%), Gaps = 3/209 (1%)
Query: 254 LAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDN 313
LA VY A++ +++ ++ P C +A +E +++ A + Y L+
Sbjct: 255 LACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCP 314
Query: 314 THVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSF 373
TH +++ + + E A+R YR+ L++ +NL + L +
Sbjct: 315 THADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHY 374
Query: 374 ERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLEMR 433
+ A+ ++ AD + N+G+ + D A QC+ A+ N A+A++NLA +
Sbjct: 375 KEAIRISPT---FADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKD 431
Query: 434 KGHVEQARALLQTASSLAPHMYEPHFNFA 462
G++ +A A +TA L P + + N A
Sbjct: 432 SGNIPEAIASYRTALKLKPDFPDAYCNLA 460
Score = 45.1 bits (105), Expect = 2e-04
Identities = 41/210 (19%), Positives = 89/210 (42%), Gaps = 3/210 (1%)
Query: 279 PGEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRF 338
P +L ++ I+ + + +A + +KQ+ EA + +G+ + Q + A+
Sbjct: 42 PDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEH 101
Query: 339 YRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAV 398
YR L++ + NL A + + ++ AL + + V +LG++
Sbjct: 102 YRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSAL---QYNPDLYCVRSDLGNLLK 158
Query: 399 GIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPH 458
+G A C+ A+ N A A++NL + +G + A + A +L P+ + +
Sbjct: 159 ALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAY 218
Query: 459 FNFATISDKIGDLQRSYVAAQKSEAAFPDH 488
N + + R+ A ++ + P+H
Sbjct: 219 INLGNVLKEARIFDRAVAAYLRALSLSPNH 248
Score = 37.7 bits (86), Expect = 0.025
Identities = 40/208 (19%), Positives = 82/208 (39%), Gaps = 3/208 (1%)
Query: 283 TLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRL 342
T L +A + + +A + ++ +Q+ + + + S HF + + + F
Sbjct: 12 TGLAELAHREYQAGDFEAAERHCMQLWRQEPDNTGVLLLLSSIHFQCRRLDRSAHFSTLA 71
Query: 343 LQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGD 402
++ + ++NLG Q + + AL L + + D + NL V GD
Sbjct: 72 IKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRL---KPDFIDGYINLAAALVAAGD 128
Query: 403 TNLAHQCFRLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFA 462
A Q + AL N + ++L L G +E+A+A A P+ N
Sbjct: 129 MEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLG 188
Query: 463 TISDKIGDLQRSYVAAQKSEAAFPDHVD 490
+ + G++ + +K+ P+ +D
Sbjct: 189 CVFNAQGEIWLAIHHFEKAVTLDPNFLD 216
Score = 33.1 bits (74), Expect = 0.61
Identities = 26/91 (28%), Positives = 45/91 (49%), Gaps = 4/91 (4%)
Query: 412 LALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGDL 471
LA+ N AEAY+NL + +G +++A + A L P + + N A GD+
Sbjct: 70 LAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDM 129
Query: 472 Q---RSYVAA-QKSEAAFPDHVDTQHLIKQL 498
+ ++YV+A Q + + D +L+K L
Sbjct: 130 EGAVQAYVSALQYNPDLYCVRSDLGNLLKAL 160
>gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens]
Length = 1046
Score = 65.9 bits (159), Expect = 8e-11
Identities = 60/302 (19%), Positives = 121/302 (40%), Gaps = 32/302 (10%)
Query: 221 IGKCYYRLGMYREAEKQFKSALK-QQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFP 279
+G Y G +EA + ++ AL+ + + +D ++ LA V+ A+ + L P
Sbjct: 95 LGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNP 154
Query: 280 GEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFY 339
+ + + + + + A Y + ++ A + +G + +A+ +
Sbjct: 155 DLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHF 214
Query: 340 RRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEE----EAADVWYNLGH 395
+ + + + NLG A+ +D + ++ RALSL+ N A V+Y G
Sbjct: 215 EKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGL 274
Query: 396 VAVGI---------------------------GDTNLAHQCFRLALVNNNNHAEAYNNLA 428
+ + I G A C+ AL HA++ NNLA
Sbjct: 275 IDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLA 334
Query: 429 VLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGDLQRSYVAAQKSEAAFPDH 488
++ +G++E+A L + A + P H N A++ + G LQ + + +++ P
Sbjct: 335 NIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTF 394
Query: 489 VD 490
D
Sbjct: 395 AD 396
Score = 64.7 bits (156), Expect = 2e-10
Identities = 48/209 (22%), Positives = 94/209 (44%), Gaps = 3/209 (1%)
Query: 254 LAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDN 313
LA VY A++ +++ ++ P C +A +E +++ A + Y L+
Sbjct: 265 LACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCP 324
Query: 314 THVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSF 373
TH +++ + + E A+R YR+ L++ +NL + L +
Sbjct: 325 THADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHY 384
Query: 374 ERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLEMR 433
+ A+ ++ AD + N+G+ + D A QC+ A+ N A+A++NLA +
Sbjct: 385 KEAIRISPT---FADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKD 441
Query: 434 KGHVEQARALLQTASSLAPHMYEPHFNFA 462
G++ +A A +TA L P + + N A
Sbjct: 442 SGNIPEAIASYRTALKLKPDFPDAYCNLA 470
Score = 45.1 bits (105), Expect = 2e-04
Identities = 41/210 (19%), Positives = 89/210 (42%), Gaps = 3/210 (1%)
Query: 279 PGEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRF 338
P +L ++ I+ + + +A + +KQ+ EA + +G+ + Q + A+
Sbjct: 52 PDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEH 111
Query: 339 YRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAV 398
YR L++ + NL A + + ++ AL + + V +LG++
Sbjct: 112 YRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSAL---QYNPDLYCVRSDLGNLLK 168
Query: 399 GIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPH 458
+G A C+ A+ N A A++NL + +G + A + A +L P+ + +
Sbjct: 169 ALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAY 228
Query: 459 FNFATISDKIGDLQRSYVAAQKSEAAFPDH 488
N + + R+ A ++ + P+H
Sbjct: 229 INLGNVLKEARIFDRAVAAYLRALSLSPNH 258
Score = 37.4 bits (85), Expect = 0.032
Identities = 39/206 (18%), Positives = 81/206 (39%), Gaps = 3/206 (1%)
Query: 285 LCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQ 344
L +A + + +A + ++ +Q+ + + + S HF + + + F ++
Sbjct: 24 LAELAHREYQAGDFEAAERHCMQLWRQEPDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIK 83
Query: 345 MGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTN 404
+ ++NLG Q + + AL L + + D + NL V GD
Sbjct: 84 QNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRL---KPDFIDGYINLAAALVAAGDME 140
Query: 405 LAHQCFRLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATI 464
A Q + AL N + ++L L G +E+A+A A P+ N +
Sbjct: 141 GAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCV 200
Query: 465 SDKIGDLQRSYVAAQKSEAAFPDHVD 490
+ G++ + +K+ P+ +D
Sbjct: 201 FNAQGEIWLAIHHFEKAVTLDPNFLD 226
Score = 33.1 bits (74), Expect = 0.61
Identities = 26/91 (28%), Positives = 45/91 (49%), Gaps = 4/91 (4%)
Query: 412 LALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGDL 471
LA+ N AEAY+NL + +G +++A + A L P + + N A GD+
Sbjct: 80 LAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDM 139
Query: 472 Q---RSYVAA-QKSEAAFPDHVDTQHLIKQL 498
+ ++YV+A Q + + D +L+K L
Sbjct: 140 EGAVQAYVSALQYNPDLYCVRSDLGNLLKAL 170
>gi|118766328 transmembrane and tetratricopeptide repeat containing
4 isoform 2 [Homo sapiens]
Length = 741
Score = 56.6 bits (135), Expect = 5e-08
Identities = 48/218 (22%), Positives = 97/218 (44%), Gaps = 3/218 (1%)
Query: 270 LFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYS 329
LF+ L P + I + + N ++A YY+E ++ + +V A+ +G+
Sbjct: 470 LFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKER 529
Query: 330 DQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADV 389
++ + A +Q+ + NLG+ ++++ S+ A+ ++ + D
Sbjct: 530 NELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAI---KHRRKYPDC 586
Query: 390 WYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASS 449
+YNLG + + A +R A V H+ A+NN+ +L G++ QA A+ + A
Sbjct: 587 YYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVGREALE 646
Query: 450 LAPHMYEPHFNFATISDKIGDLQRSYVAAQKSEAAFPD 487
L P+ + F+ A + K + S K+ A P+
Sbjct: 647 LIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANPN 684
Score = 35.4 bits (80), Expect = 0.12
Identities = 53/289 (18%), Positives = 100/289 (34%), Gaps = 38/289 (13%)
Query: 223 KCYYRLGMYREAEKQFKSALKQQEMVDTFLY-LAKVYVSLDQPVTALNLFKQGLDKFPGE 281
+C R G +R E+ F+SAL + Y + K A+ +++ + P
Sbjct: 456 RCVLRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKY 515
Query: 282 VTLLCGIARIYEEMNNMSSAAEY----------------------------------YKE 307
V + + I +E N + A E Y+
Sbjct: 516 VHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRT 575
Query: 308 VLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYD 367
+K + + +G + ++ AL +R + + +NN+ +
Sbjct: 576 AIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNMIILLDNTGNLA 635
Query: 368 MTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNL 427
AL L N+ + ++L +V + F A+ N N A + NL
Sbjct: 636 QAEAVGREALELIPNDHS---LMFSLANVLGKSQKYKESEALFLKAIKANPNAASYHGNL 692
Query: 428 AVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGDLQRSYV 476
AVL R GH++ A+ + + L P N+ + K+ +Q+ V
Sbjct: 693 AVLYHRWGHLDLAKKHYEISLQLDPTASGTKENYGLLRRKLELMQKKAV 741
>gi|118766330 transmembrane and tetratricopeptide repeat containing
4 isoform 1 [Homo sapiens]
Length = 760
Score = 56.6 bits (135), Expect = 5e-08
Identities = 48/218 (22%), Positives = 97/218 (44%), Gaps = 3/218 (1%)
Query: 270 LFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYS 329
LF+ L P + I + + N ++A YY+E ++ + +V A+ +G+
Sbjct: 489 LFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKER 548
Query: 330 DQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADV 389
++ + A +Q+ + NLG+ ++++ S+ A+ ++ + D
Sbjct: 549 NELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAI---KHRRKYPDC 605
Query: 390 WYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASS 449
+YNLG + + A +R A V H+ A+NN+ +L G++ QA A+ + A
Sbjct: 606 YYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVGREALE 665
Query: 450 LAPHMYEPHFNFATISDKIGDLQRSYVAAQKSEAAFPD 487
L P+ + F+ A + K + S K+ A P+
Sbjct: 666 LIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANPN 703
Score = 35.4 bits (80), Expect = 0.12
Identities = 53/289 (18%), Positives = 100/289 (34%), Gaps = 38/289 (13%)
Query: 223 KCYYRLGMYREAEKQFKSALKQQEMVDTFLY-LAKVYVSLDQPVTALNLFKQGLDKFPGE 281
+C R G +R E+ F+SAL + Y + K A+ +++ + P
Sbjct: 475 RCVLRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKY 534
Query: 282 VTLLCGIARIYEEMNNMSSAAEY----------------------------------YKE 307
V + + I +E N + A E Y+
Sbjct: 535 VHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRT 594
Query: 308 VLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYD 367
+K + + +G + ++ AL +R + + +NN+ +
Sbjct: 595 AIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNMIILLDNTGNLA 654
Query: 368 MTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNL 427
AL L N+ + ++L +V + F A+ N N A + NL
Sbjct: 655 QAEAVGREALELIPNDHS---LMFSLANVLGKSQKYKESEALFLKAIKANPNAASYHGNL 711
Query: 428 AVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGDLQRSYV 476
AVL R GH++ A+ + + L P N+ + K+ +Q+ V
Sbjct: 712 AVLYHRWGHLDLAKKHYEISLQLDPTASGTKENYGLLRRKLELMQKKAV 760
>gi|167466177 cell division cycle protein 27 isoform 1 [Homo
sapiens]
Length = 830
Score = 52.0 bits (123), Expect = 1e-06
Identities = 44/170 (25%), Positives = 76/170 (44%), Gaps = 5/170 (2%)
Query: 284 LLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRR-L 342
+LC I R Y E++ A + EV + +N VE + I S + Q ++AL + L
Sbjct: 507 VLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGME-IYSTTLWHLQKDVALSVLSKDL 565
Query: 343 LQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGD 402
M + + + G C +++D+ + F+RA+ + N A + LGH V +
Sbjct: 566 TDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTL---LGHEFVLTEE 622
Query: 403 TNLAHQCFRLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAP 452
+ A CFR A+ N H A+ L ++ ++ A Q A + P
Sbjct: 623 LDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINP 672
Score = 46.2 bits (108), Expect = 7e-05
Identities = 33/184 (17%), Positives = 74/184 (40%), Gaps = 2/184 (1%)
Query: 197 KTALDLAALSTEHSQYKDWWWKVQIGKCYYRLGMYREAEKQFKSALK-QQEMVDTFLYLA 255
K A+++ + H Y W QIG+ Y+ L Y +AE+ F + + V+ +
Sbjct: 488 KEAINILSHLPSH-HYNTGWVLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYS 546
Query: 256 KVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTH 315
L + V L K D C + A ++++ ++ D +
Sbjct: 547 TTLWHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNY 606
Query: 316 VEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFER 375
A +G +++ + AL +R +++ + + LG+ + +++ + F++
Sbjct: 607 AYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQK 666
Query: 376 ALSL 379
AL +
Sbjct: 667 ALDI 670
>gi|167466175 cell division cycle protein 27 isoform 2 [Homo
sapiens]
Length = 824
Score = 52.0 bits (123), Expect = 1e-06
Identities = 44/170 (25%), Positives = 76/170 (44%), Gaps = 5/170 (2%)
Query: 284 LLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRR-L 342
+LC I R Y E++ A + EV + +N VE + I S + Q ++AL + L
Sbjct: 501 VLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGME-IYSTTLWHLQKDVALSVLSKDL 559
Query: 343 LQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGD 402
M + + + G C +++D+ + F+RA+ + N A + LGH V +
Sbjct: 560 TDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTL---LGHEFVLTEE 616
Query: 403 TNLAHQCFRLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAP 452
+ A CFR A+ N H A+ L ++ ++ A Q A + P
Sbjct: 617 LDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINP 666
Score = 46.2 bits (108), Expect = 7e-05
Identities = 33/184 (17%), Positives = 74/184 (40%), Gaps = 2/184 (1%)
Query: 197 KTALDLAALSTEHSQYKDWWWKVQIGKCYYRLGMYREAEKQFKSALK-QQEMVDTFLYLA 255
K A+++ + H Y W QIG+ Y+ L Y +AE+ F + + V+ +
Sbjct: 482 KEAINILSHLPSH-HYNTGWVLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYS 540
Query: 256 KVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTH 315
L + V L K D C + A ++++ ++ D +
Sbjct: 541 TTLWHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNY 600
Query: 316 VEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFER 375
A +G +++ + AL +R +++ + + LG+ + +++ + F++
Sbjct: 601 AYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQK 660
Query: 376 ALSL 379
AL +
Sbjct: 661 ALDI 664
>gi|7661950 SH2 domain binding protein 1 [Homo sapiens]
Length = 1173
Score = 51.6 bits (122), Expect = 2e-06
Identities = 61/310 (19%), Positives = 114/310 (36%), Gaps = 64/310 (20%)
Query: 221 IGKCYYRLGMYREAEKQFKSALKQQEM-------------VDTFLYLAKVYVSLDQPVTA 267
+G ++RLG EA+K F ++L + + V T LA++Y ++ + A
Sbjct: 457 VGALHFRLGNLGEAKKYFLASLDRAKAEAEHDEHYYNAISVTTSYNLARLYEAMCEFHEA 516
Query: 268 LNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHF 327
L+K L + P V + + + N A++++KE L+ + H +A + IG+ H
Sbjct: 517 EKLYKNILREHPNYVDCYLRLGAMARDKGNFYEASDWFKEALQINQDHPDAWSLIGNLHL 576
Query: 328 YSDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQ--------------QYDMTLTSF 373
+ + + R+L+ ++ L L + Q D L +
Sbjct: 577 AKQEWGPGQKKFERILKQPSTQSDTYSMLALGNVWLQTLHQPTRDREKEKRHQDRALAIY 636
Query: 374 ERAL-------------------------------SLAENEEEAADVWYNLGHVAVG--- 399
++ L + E + +DVW NL H+ V
Sbjct: 637 KQVLRNDAKNLYAANGIGAVLAHKGYFREARDVFAQVREATADISDVWLNLAHIYVEQKQ 696
Query: 400 -IGDTNLAHQCFRLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPH 458
I + C R + N Y LA + G +++ + L A +AP
Sbjct: 697 YISAVQMYENCLRKFYKHQNTEVVLY--LARALFKCGKLQECKQTLLKARHVAPSDTVLM 754
Query: 459 FNFATISDKI 468
FN A + ++
Sbjct: 755 FNVALVLQRL 764
Score = 29.3 bits (64), Expect = 8.8
Identities = 53/259 (20%), Positives = 97/259 (37%), Gaps = 54/259 (20%)
Query: 233 EAEKQFKSALKQQ-EMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPG---EVTLLCGI 288
+A+ QF L Q + L A + + AL +K+ L PG EV L G+
Sbjct: 147 QADAQFHFVLNQSPNNIPALLGKACISFNKKDYRGALAYYKKALRTNPGCPAEVRL--GM 204
Query: 289 ARIYEEMNNMSSAAEYYKEVLKQDNTHVEAI---ACIGSNHFYSDQPEIALRFYRRLLQM 345
+ ++N + A + L+ ++ V A+ A + N+ +D + ++ R +
Sbjct: 205 GHCFVKLNKLEKARLAFSRALELNSKCVGALVGLAVLELNNKEADSIKNGVQLLSRAYTI 264
Query: 346 GIYNGQLFNNLGLCCFYAQQYD----MTLTSFE----------------RALSLAENEEE 385
N + N+L F+ + Y + L +F R+ + E+ ++
Sbjct: 265 DPSNPMVLNHLANHFFFKKDYSKVQHLALHAFHNTEVEAMQAESCYQLARSFHVQEDYDQ 324
Query: 386 AADVWYN---------------LGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLAVL 430
A +Y LG + + GD A QCF L N+ E L L
Sbjct: 325 AFQYYYQATQFASSSFVLPFFGLGQMYIYRGDKENASQCFEKVLKAYPNNYETMKILGSL 384
Query: 431 ----------EMRKGHVEQ 439
++ KGH+++
Sbjct: 385 YAASEDQEKRDIAKGHLKK 403
Score = 29.3 bits (64), Expect = 8.8
Identities = 27/95 (28%), Positives = 39/95 (41%), Gaps = 4/95 (4%)
Query: 356 LGLCC--FYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLA 413
LG C F + Y L +++AL N A+V +GH V + A F A
Sbjct: 167 LGKACISFNKKDYRGALAYYKKALRT--NPGCPAEVRLGMGHCFVKLNKLEKARLAFSRA 224
Query: 414 LVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTAS 448
L N+ A LAVLE+ + + +Q S
Sbjct: 225 LELNSKCVGALVGLAVLELNNKEADSIKNGVQLLS 259
>gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens]
Length = 2481
Score = 50.1 bits (118), Expect = 5e-06
Identities = 49/206 (23%), Positives = 86/206 (41%), Gaps = 24/206 (11%)
Query: 273 QGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVL------KQDNTHVEAIACIGSNH 326
Q L PGE +A +Y + + A + Y+E L K + + +G
Sbjct: 785 QELSDLPGECRAHGHLAAVYMALGKYTMAFKCYEEQLDLGQKLKDPSLEAQVYGNMGITK 844
Query: 327 FYSDQPEIALRFYRRLLQM---------GIYNGQLFNNLGLCCFYAQQYDMTLTSFERAL 377
+ E A+ ++ + L M + G+ + NLG C Y+ + +E+ L
Sbjct: 845 MNMNVMEEAIGYFEQQLAMLQQLSGNESVLDRGRAYGNLGDCYEALGDYEEAIKYYEQYL 904
Query: 378 SLAEN---EEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNN------NHAEAYNNLA 428
S+A++ ++ A + LG+ +G A CF LV + N A+AY L
Sbjct: 905 SVAQSLNRMQDQAKAYRGLGNGHRAMGSLQQALVCFEKRLVVAHELGEAFNKAQAYGELG 964
Query: 429 VLEMRKGHVEQARALLQTASSLAPHM 454
L + G+ EQA + L+ ++A M
Sbjct: 965 SLHSQLGNYEQAISCLERQLNIARDM 990
Score = 42.7 bits (99), Expect = 8e-04
Identities = 61/264 (23%), Positives = 109/264 (41%), Gaps = 34/264 (12%)
Query: 221 IGKCYYRLGMYREAEKQFKSALKQQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPG 280
+G CY LG Y EA K ++ L + ++ AK Y L A+ +Q L F
Sbjct: 883 LGDCYEALGDYEEAIKYYEQYLSVAQSLNRMQDQAKAYRGLGNGHRAMGSLQQALVCFEK 942
Query: 281 EVTLLCGI------ARIYEEMNNMSSAAEYYKEVLK-----------QDNTHVEAIACIG 323
+ + + A+ Y E+ ++ S Y++ + + +E+ A G
Sbjct: 943 RLVVAHELGEAFNKAQAYGELGSLHSQLGNYEQAISCLERQLNIARDMKDRALESDAACG 1002
Query: 324 SNHFYSDQPE--IALRFYRRLLQMG------IYNGQLFNNLGLCCFYAQQYDMTLTSFER 375
Y E AL++++ LQ+ G+ + NLGL ++ + E+
Sbjct: 1003 LGGVYQQMGEYDTALQYHQLDLQIAEETNNPTCQGRAYGNLGLTYESLGTFERAVVYQEQ 1062
Query: 376 ALSLAE--NEEEAADVWY-NLGHVAVGIGDTNLA----HQCFRLA--LVNNNNHAEAYNN 426
LS+A N+ A V Y +LG + + + A + RLA L + A+ +
Sbjct: 1063 HLSIAAQMNDLAAKTVSYSSLGRTHHALQNYSQAVMYLQEGLRLAEQLGRREDEAKIRHG 1122
Query: 427 LAVLEMRKGHVEQARALLQTASSL 450
L + G++E+A+ L AS+L
Sbjct: 1123 LGLSLWASGNLEEAQHQLYRASAL 1146
Score = 40.8 bits (94), Expect = 0.003
Identities = 53/244 (21%), Positives = 96/244 (39%), Gaps = 31/244 (12%)
Query: 221 IGKCYYRLGMYREAEKQFKSALKQQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPG 280
+G +Y LG Y+EA K ++ L + + L AK Y +L AL F + +
Sbjct: 640 LGYAHYCLGNYQEAVKYYEQDLALAKDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKY 699
Query: 281 EVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYR 340
++L + + + + + + + K+D G+ FY Q +A +
Sbjct: 700 LLSLAQSLNNSQAKFRALGNLGDIF--ICKKDIN--------GAIKFYEQQLGLAHQVKD 749
Query: 341 RLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVA--- 397
R L+ Y LG Q+YD L + L + + + GH+A
Sbjct: 750 RRLEASAYAA-----LGTAYRMIQKYDKALGYHTQELEVYQELSDLPGECRAHGHLAAVY 804
Query: 398 VGIGDTNLAHQCFR------LALVNNNNHAEAYNNLAVLEMRK-------GHVEQARALL 444
+ +G +A +C+ L + + A+ Y N+ + +M G+ EQ A+L
Sbjct: 805 MALGKYTMAFKCYEEQLDLGQKLKDPSLEAQVYGNMGITKMNMNVMEEAIGYFEQQLAML 864
Query: 445 QTAS 448
Q S
Sbjct: 865 QQLS 868
Score = 33.1 bits (74), Expect = 0.61
Identities = 30/95 (31%), Positives = 41/95 (43%), Gaps = 9/95 (9%)
Query: 355 NLGLCCFYAQQYDMTLTSFERALSLA---ENEEEAADVWYNLGHVAVGIGDTNLA----H 407
NLG F Y LT+ L LA ++ E A+ +LGHV IGD A
Sbjct: 279 NLGSAFFSKGNYREALTNHRHQLVLAMKLKDREAASSALSSLGHVYTAIGDYPNALASHK 338
Query: 408 QCFRLALVNNNNHAEA--YNNLAVLEMRKGHVEQA 440
QC LA + + +EA N+ + + G E A
Sbjct: 339 QCVLLAKQSKDELSEARELGNMGAVYIAMGDFENA 373
>gi|83415184 transmembrane and tetratricopeptide repeat containing 1
[Homo sapiens]
Length = 774
Score = 48.9 bits (115), Expect = 1e-05
Identities = 53/258 (20%), Positives = 112/258 (43%), Gaps = 37/258 (14%)
Query: 231 YREAEKQFKSALKQ-QEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIA 289
++EAE+ +++ +K + D V P A+ ++Q + P + +
Sbjct: 490 FKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLG 549
Query: 290 RIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRR-------- 341
R+Y + S A E+YK L+ + E ++ +G+ ++ + + E AL+ Y+
Sbjct: 550 RLYRSLGENSMAEEWYKRALQVAHK-AEILSPLGALYYNTGRYEEALQIYQEAAALQPSQ 608
Query: 342 ------LLQMGIYNGQ------LFNNLG------------LCCFYAQQ--YDMTLTSFER 375
L Q+ GQ + N++ L Y++Q +D L + ++
Sbjct: 609 RELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDK 668
Query: 376 ALSLAENEEEA-ADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLEMRK 434
AL L + + +++++ G+ + A + +R+A+ N + A+A+ N+ ++ K
Sbjct: 669 ALQLKPKDPKVISELFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIK 728
Query: 435 GHVEQARALLQTASSLAP 452
G ARA + A L P
Sbjct: 729 GKYVSARAYYERALQLVP 746
Score = 47.0 bits (110), Expect = 4e-05
Identities = 47/225 (20%), Positives = 91/225 (40%), Gaps = 13/225 (5%)
Query: 269 NLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFY 328
+LF+ G+ P + A ++ A +Y+ LK H A+ +G+
Sbjct: 362 SLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGT--LT 419
Query: 329 SDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAAD 388
D E A +Y+R LQ+ + + NLG ++ + +T + ++ E AD
Sbjct: 420 RDTAE-AKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGP---EFAD 475
Query: 389 VWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTAS 448
+ +L + A + ++ + N + ++ +NN V + G E+A A Q A
Sbjct: 476 AYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAI 535
Query: 449 SLAPHMYEPHFNFATISDKIGD-------LQRSYVAAQKSEAAFP 486
L+P + N + +G+ +R+ A K+E P
Sbjct: 536 KLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSP 580
Score = 32.3 bits (72), Expect = 1.0
Identities = 37/169 (21%), Positives = 64/169 (37%), Gaps = 5/169 (2%)
Query: 221 IGKCYYRLGMYREAEKQFKSALK-QQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFP 279
+G YY G Y EA + ++ A Q + L LA+V + Q A + + +
Sbjct: 581 LGALYYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEET 640
Query: 280 GEVTLLCGIARIYEEMNNMSSAAEYYKEVL----KQDNTHVEAIACIGSNHFYSDQPEIA 335
G + ++ IY + N A + + L K E G+ + + A
Sbjct: 641 GCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQLREQNLLDKA 700
Query: 336 LRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEE 384
YR +Q+ Q + N+G +Y +ERAL L + +
Sbjct: 701 FESYRVAVQLNPDQAQAWMNMGGIQHIKGKYVSARAYYERALQLVPDSK 749
>gi|224809432 transmembrane and tetratricopeptide repeat containing
3 [Homo sapiens]
Length = 914
Score = 47.0 bits (110), Expect = 4e-05
Identities = 53/217 (24%), Positives = 85/217 (39%), Gaps = 21/217 (9%)
Query: 267 ALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYY---KEVLKQDNTHVEAIACIG 323
AL F Q P ++ + R Y+ +N A E Y K ++ Q + A I
Sbjct: 465 ALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARIA 524
Query: 324 SNHFY------------SDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLT 371
NH + E A + YR+ + M Q + + G +
Sbjct: 525 PNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKE 584
Query: 372 SFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLE 431
++ +AL L N AD+WYNL V + + + N A + F AL N H A N A++
Sbjct: 585 AYLKALELDRNN---ADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVM 641
Query: 432 MRKGHVE---QARALLQTASSLAPHMYEPHFNFATIS 465
G V+ +AR L + + P +FN ++
Sbjct: 642 QESGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLA 678
Score = 45.4 bits (106), Expect = 1e-04
Identities = 53/257 (20%), Positives = 101/257 (39%), Gaps = 16/257 (6%)
Query: 205 LSTEHSQYKDWWWKVQIGKCYYRLGMYREAEKQFKSALK-QQEMVDTFLYLAK------- 256
L H Q D + +G+ Y L +EAE+ + A +++ Y A+
Sbjct: 470 LQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLN 529
Query: 257 VYVSLDQPVTALN--------LFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEV 308
VY++L + A L++Q + P + +MN A E Y +
Sbjct: 530 VYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKA 589
Query: 309 LKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDM 368
L+ D + + + H +P AL+ + R L++ + N + + + +
Sbjct: 590 LELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKL 649
Query: 369 TLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLA 428
+ +R LS E A+ ++NLG +A+ N A + A+ + A NLA
Sbjct: 650 RPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLA 709
Query: 429 VLEMRKGHVEQARALLQ 445
+L + +A +L+
Sbjct: 710 LLYSQTAKELKALPILE 726
>gi|7662078 tetratricopeptide repeat domain 37 [Homo sapiens]
Length = 1564
Score = 45.4 bits (106), Expect = 1e-04
Identities = 64/278 (23%), Positives = 118/278 (42%), Gaps = 49/278 (17%)
Query: 228 LGMYREAEKQFKSALKQQE--------MVDTFLYLAKVYV-------SLDQPVTALNLFK 272
LG Y+EA Q++ +K++E + + L +AK + ++D AL F
Sbjct: 645 LGKYKEAVAQYQMIIKKKEDYVPALKGLGECHLMMAKAALVDYLDGKAVDYIEKALEYFT 704
Query: 273 QGLD---------KFPGEV-TLLCGIA--RIYEEMNNMSSAAEYYKEVLKQDNT------ 314
L K G+ T L +A ++ + + + K+VLK++
Sbjct: 705 CALQHRADVSCLWKLAGDACTCLYAVAPSKVNVHVLGVLLGQKEGKQVLKKNELLHLGGR 764
Query: 315 -HVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSF 373
+ A+ + +++ + D + + +YR+ + G N+L + + +L
Sbjct: 765 CYGRALKLMSTSNTWCD---LGINYYRQAQHLA-ETGSNMNDL------KELLEKSLHCL 814
Query: 374 ERALSLAENEEEAADVWYNLGHVAV--GIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLE 431
++A+ L N W LG VA GIG+ LA CF ++ + +A A+ NL VL
Sbjct: 815 KKAVRLDSNNHL---YWNALGVVACYSGIGNYALAQHCFIKSIQSEQINAVAWTNLGVLY 871
Query: 432 MRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIG 469
+ ++EQA + A SL P A I++ +G
Sbjct: 872 LTNENIEQAHEAFKMAQSLDPSYLMCWIGQALIAEAVG 909
Score = 38.9 bits (89), Expect = 0.011
Identities = 19/71 (26%), Positives = 42/71 (59%), Gaps = 1/71 (1%)
Query: 231 YREAEKQFKSALKQQEM-VDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIA 289
Y+EA K K+ LKQ++ + ++++ L+QP A + +K+ + P ++ G+A
Sbjct: 22 YKEALKHCKTVLKQEKNNYNAWVFIGVAAAELEQPDQAQSAYKKAAELEPDQLLAWQGLA 81
Query: 290 RIYEEMNNMSS 300
+YE+ N++++
Sbjct: 82 NLYEKYNHINA 92
Score = 37.7 bits (86), Expect = 0.025
Identities = 29/135 (21%), Positives = 60/135 (44%), Gaps = 4/135 (2%)
Query: 195 DVKTALDLAALSTEHSQY--KDWWWKVQIGKCYYRLGMYREAEKQFKSALKQQEM-VDTF 251
D++ AL + T+ + W W ++ G Y + G + +A ++AL+ + +
Sbjct: 543 DMEMALAILTTVTQKASAGTAKWAW-LRRGLYYLKAGQHSQAVADLQAALRADPKDFNCW 601
Query: 252 LYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQ 311
L + Y+S TAL F + + P + + +A I + + A Y+ ++K+
Sbjct: 602 ESLGEAYLSRGGYTTALKSFTKASELNPESIYSVFKVAAIQQILGKYKEAVAQYQMIIKK 661
Query: 312 DNTHVEAIACIGSNH 326
+V A+ +G H
Sbjct: 662 KEDYVPALKGLGECH 676
Score = 34.7 bits (78), Expect = 0.21
Identities = 48/200 (24%), Positives = 79/200 (39%), Gaps = 13/200 (6%)
Query: 258 YVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVE 317
Y S ++ + L+ D PG + L + Y + AA+ +++L E
Sbjct: 366 YDSSEEAIRTLDQISDA-DNIPGLLVLK---SLAYRNKGSFDEAAKIMEDLLSSYPDLAE 421
Query: 318 AIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQY---DMT--LTS 372
A HF A + ++R L+ + LGL ++ + D T LT
Sbjct: 422 VHALEALIHFTKKDYLQAEKCFQRALEKDTEVAEYHYQLGLTYWFMGEETRKDKTKALTH 481
Query: 373 FERALSLAENEEEAADVWYNLGHVAVGI-GDTNLAHQCFRLALVNNNNHAEAYNNLAVLE 431
F +A L + V+ LGH + GD N A C+R A ++ AE+ L
Sbjct: 482 FLKAARL---DTYMGKVFCYLGHYYRDVVGDKNRARGCYRKAFELDDTDAESGAAAVDLS 538
Query: 432 MRKGHVEQARALLQTASSLA 451
+ +E A A+L T + A
Sbjct: 539 VELEDMEMALAILTTVTQKA 558
Score = 31.2 bits (69), Expect = 2.3
Identities = 39/165 (23%), Positives = 63/165 (38%), Gaps = 15/165 (9%)
Query: 330 DQPEIALRFYRRLL-QMGIYNG--QLFNN-----------LGLCCFYAQQYDMTLTSFER 375
D +A+R Y RLL G Y+ Q F + L F Y + ++ER
Sbjct: 1017 DTYNVAIRNYGRLLCSTGEYDKAIQAFKSTPLEVLEDIIGFALALFMKGLYKESSKAYER 1076
Query: 376 ALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLEMRKG 435
ALS+ E+E++ A + L G T++A + E+ L L +
Sbjct: 1077 ALSIVESEQDKAHILTALAITEYKQGKTDVAKTLLFKCSILKEPTTESLQALCALGLAMQ 1136
Query: 436 HVEQARALLQTASSLAPHMYEPHFNFATISDKIGDLQRSYVAAQK 480
++A L H + ++ ++ I LQ VA QK
Sbjct: 1137 DATLSKAALNELLKHIKHK-DSNYQRCLLTSAIYALQGRSVAVQK 1180
>gi|170784869 tetratricopeptide repeat domain 13 isoform b [Homo
sapiens]
Length = 807
Score = 44.3 bits (103), Expect = 3e-04
Identities = 38/172 (22%), Positives = 66/172 (38%), Gaps = 1/172 (0%)
Query: 228 LGMYREAEKQFKSALKQQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCG 287
LG EA A++ Q + + +Y + TA F+Q L+ + +
Sbjct: 176 LGRINEAVNDLTKAIQLQPSARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQPIAMLY 235
Query: 288 IARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGI 347
+ + A E +KE LKQ ++A +G + E A +++ L +
Sbjct: 236 KGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQ 295
Query: 348 YNGQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVG 399
+ Q G+ ++ L +F+R L L E E L HVA+G
Sbjct: 296 NHVQTLQLRGMMLYHHGSLQEALKNFKRCLQL-EPYNEVCQYMKGLSHVAMG 346
Score = 42.4 bits (98), Expect = 0.001
Identities = 28/129 (21%), Positives = 56/129 (43%), Gaps = 1/129 (0%)
Query: 222 GKCYYRLGMYREAEKQFKSALK-QQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPG 280
G Y+ Y A + F+ +L+ + LY + A+ FK+ L +
Sbjct: 203 GTLYFISEDYATAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVD 262
Query: 281 EVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYR 340
+ + + Y E+ N +A E +++ L + HV+ + G ++ + AL+ ++
Sbjct: 263 FIDAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFK 322
Query: 341 RLLQMGIYN 349
R LQ+ YN
Sbjct: 323 RCLQLEPYN 331
Score = 38.1 bits (87), Expect = 0.019
Identities = 35/184 (19%), Positives = 76/184 (41%), Gaps = 11/184 (5%)
Query: 270 LFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYS 329
L+ + + F + +L + RI E +N+++ A + + G+ +F S
Sbjct: 158 LYDEAIRHFSTMLQILSPLGRINEAVNDLTKAIQLQPSARLYRHR--------GTLYFIS 209
Query: 330 DQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADV 389
+ A +++ L++ GL F+ + SF+ AL + + + D
Sbjct: 210 EDYATAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEAL---KQKVDFIDA 266
Query: 390 WYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASS 449
+ +LG +G+ A + F+ AL+ N NH + ++ G +++A +
Sbjct: 267 YKSLGQAYRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQ 326
Query: 450 LAPH 453
L P+
Sbjct: 327 LEPY 330
>gi|170784867 tetratricopeptide repeat domain 13 isoform a [Homo
sapiens]
Length = 860
Score = 44.3 bits (103), Expect = 3e-04
Identities = 38/172 (22%), Positives = 66/172 (38%), Gaps = 1/172 (0%)
Query: 228 LGMYREAEKQFKSALKQQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCG 287
LG EA A++ Q + + +Y + TA F+Q L+ + +
Sbjct: 229 LGRINEAVNDLTKAIQLQPSARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQPIAMLY 288
Query: 288 IARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGI 347
+ + A E +KE LKQ ++A +G + E A +++ L +
Sbjct: 289 KGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQ 348
Query: 348 YNGQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVG 399
+ Q G+ ++ L +F+R L L E E L HVA+G
Sbjct: 349 NHVQTLQLRGMMLYHHGSLQEALKNFKRCLQL-EPYNEVCQYMKGLSHVAMG 399
Score = 42.4 bits (98), Expect = 0.001
Identities = 28/129 (21%), Positives = 56/129 (43%), Gaps = 1/129 (0%)
Query: 222 GKCYYRLGMYREAEKQFKSALK-QQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPG 280
G Y+ Y A + F+ +L+ + LY + A+ FK+ L +
Sbjct: 256 GTLYFISEDYATAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVD 315
Query: 281 EVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYR 340
+ + + Y E+ N +A E +++ L + HV+ + G ++ + AL+ ++
Sbjct: 316 FIDAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFK 375
Query: 341 RLLQMGIYN 349
R LQ+ YN
Sbjct: 376 RCLQLEPYN 384
Score = 39.3 bits (90), Expect = 0.008
Identities = 43/238 (18%), Positives = 95/238 (39%), Gaps = 24/238 (10%)
Query: 229 GMYREAEKQFKSALKQQEMVDTFLY-------------LAKVYVSLDQPVTALNLFKQGL 275
G+Y EA + F + L+++ + + +Y + ++L + + L
Sbjct: 157 GLYDEAIRHFSTMLQEEPDLVSAIYGRGIAYGKKGLHDIKNAELALFELSRVITLEPDRP 216
Query: 276 DKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIA 335
+ F +L + RI E +N+++ A + + G+ +F S+ A
Sbjct: 217 EVFEQRAEILSPLGRINEAVNDLTKAIQLQPSARLYRHR--------GTLYFISEDYATA 268
Query: 336 LRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGH 395
+++ L++ GL F+ + SF+ AL + + + D + +LG
Sbjct: 269 HEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEAL---KQKVDFIDAYKSLGQ 325
Query: 396 VAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAPH 453
+G+ A + F+ AL+ N NH + ++ G +++A + L P+
Sbjct: 326 AYRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEPY 383
>gi|28558993 intraflagellar transport 88 homolog isoform 1 [Homo
sapiens]
Length = 833
Score = 43.5 bits (101), Expect = 4e-04
Identities = 38/156 (24%), Positives = 65/156 (41%), Gaps = 1/156 (0%)
Query: 222 GKCYYRLGMYREAEKQFKSALKQQEMVDTFLY-LAKVYVSLDQPVTALNLFKQGLDKFPG 280
G + G Y +A + +K AL+ LY + Y L++ AL+ F +
Sbjct: 500 GNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAILRN 559
Query: 281 EVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYR 340
+L IA IYE M N S A E+ +V+ T + ++ +G + A ++Y
Sbjct: 560 SAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGDKSQAFQYYY 619
Query: 341 RLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERA 376
+ N ++ LG Q ++ + FERA
Sbjct: 620 ESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERA 655
Score = 40.4 bits (93), Expect = 0.004
Identities = 27/122 (22%), Positives = 54/122 (44%), Gaps = 1/122 (0%)
Query: 221 IGKCYYRLGMYREAEKQF-KSALKQQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFP 279
IG Y +L EA F K + + +A +Y ++ P A+ Q + P
Sbjct: 533 IGLTYEKLNRLDEALDCFLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIP 592
Query: 280 GEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFY 339
+ +L + +Y+ + S A +YY E + ++E I +G+ + + E A++++
Sbjct: 593 TDPQVLSKLGELYDREGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYF 652
Query: 340 RR 341
R
Sbjct: 653 ER 654
Score = 37.0 bits (84), Expect = 0.042
Identities = 44/201 (21%), Positives = 75/201 (37%), Gaps = 28/201 (13%)
Query: 283 TLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEI--ALRFYR 340
++L +A Y + A Y+ ++K I + + Y Q A++FYR
Sbjct: 207 SVLFNLASQYSVNEMYAEALNTYQVIVKNKMFSNAGILKMNMGNIYLKQRNYSKAIKFYR 266
Query: 341 RLL-QMGIYNGQL----FNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGH 395
L Q+ N Q+ N+G+ A QY + S+E +S+A N + YNL
Sbjct: 267 MALDQVPSVNKQMRIKIMQNIGVTFIQAGQYSDAINSYEHIMSMAPNLKAG----YNLTI 322
Query: 396 VAVGIGDTNLAHQCFRLALV-----------------NNNNHAEAYNNLAVLEMRKGHVE 438
IGD + F+ + + N EA N + +M +
Sbjct: 323 CYFAIGDREKMKKAFQKLITVPLEIDEDKYISPSDDPHTNLVTEAIKNDHLRQMERERKA 382
Query: 439 QARALLQTASSLAPHMYEPHF 459
A + T++ L + E F
Sbjct: 383 MAEKYIMTSAKLIAPVIETSF 403
Score = 34.7 bits (78), Expect = 0.21
Identities = 41/200 (20%), Positives = 72/200 (36%), Gaps = 4/200 (2%)
Query: 292 YEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRL-LQMGIYNG 350
Y + + A E K + K+D+ A A S +Y + Y + + YN
Sbjct: 434 YLRQKDYNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYADIAVNSDRYNP 493
Query: 351 QLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCF 410
N G F Y+ ++ AL N+ + YN+G + + A CF
Sbjct: 494 AALTNKGNTVFANGDYEKAAEFYKEAL---RNDSSCTEALYNIGLTYEKLNRLDEALDCF 550
Query: 411 RLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGD 470
N AE +A + + QA L S+ P + + D+ GD
Sbjct: 551 LKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGD 610
Query: 471 LQRSYVAAQKSEAAFPDHVD 490
+++ +S FP +++
Sbjct: 611 KSQAFQYYYESYRYFPCNIE 630
>gi|28329439 intraflagellar transport 88 homolog isoform 2 [Homo
sapiens]
Length = 824
Score = 43.5 bits (101), Expect = 4e-04
Identities = 38/156 (24%), Positives = 65/156 (41%), Gaps = 1/156 (0%)
Query: 222 GKCYYRLGMYREAEKQFKSALKQQEMVDTFLY-LAKVYVSLDQPVTALNLFKQGLDKFPG 280
G + G Y +A + +K AL+ LY + Y L++ AL+ F +
Sbjct: 491 GNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAILRN 550
Query: 281 EVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYR 340
+L IA IYE M N S A E+ +V+ T + ++ +G + A ++Y
Sbjct: 551 SAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGDKSQAFQYYY 610
Query: 341 RLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERA 376
+ N ++ LG Q ++ + FERA
Sbjct: 611 ESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERA 646
Score = 40.4 bits (93), Expect = 0.004
Identities = 27/122 (22%), Positives = 54/122 (44%), Gaps = 1/122 (0%)
Query: 221 IGKCYYRLGMYREAEKQF-KSALKQQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFP 279
IG Y +L EA F K + + +A +Y ++ P A+ Q + P
Sbjct: 524 IGLTYEKLNRLDEALDCFLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIP 583
Query: 280 GEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFY 339
+ +L + +Y+ + S A +YY E + ++E I +G+ + + E A++++
Sbjct: 584 TDPQVLSKLGELYDREGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYF 643
Query: 340 RR 341
R
Sbjct: 644 ER 645
Score = 37.0 bits (84), Expect = 0.042
Identities = 44/201 (21%), Positives = 75/201 (37%), Gaps = 28/201 (13%)
Query: 283 TLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEI--ALRFYR 340
++L +A Y + A Y+ ++K I + + Y Q A++FYR
Sbjct: 198 SVLFNLASQYSVNEMYAEALNTYQVIVKNKMFSNAGILKMNMGNIYLKQRNYSKAIKFYR 257
Query: 341 RLL-QMGIYNGQL----FNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGH 395
L Q+ N Q+ N+G+ A QY + S+E +S+A N + YNL
Sbjct: 258 MALDQVPSVNKQMRIKIMQNIGVTFIQAGQYSDAINSYEHIMSMAPNLKAG----YNLTI 313
Query: 396 VAVGIGDTNLAHQCFRLALV-----------------NNNNHAEAYNNLAVLEMRKGHVE 438
IGD + F+ + + N EA N + +M +
Sbjct: 314 CYFAIGDREKMKKAFQKLITVPLEIDEDKYISPSDDPHTNLVTEAIKNDHLRQMERERKA 373
Query: 439 QARALLQTASSLAPHMYEPHF 459
A + T++ L + E F
Sbjct: 374 MAEKYIMTSAKLIAPVIETSF 394
Score = 34.7 bits (78), Expect = 0.21
Identities = 41/200 (20%), Positives = 72/200 (36%), Gaps = 4/200 (2%)
Query: 292 YEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRL-LQMGIYNG 350
Y + + A E K + K+D+ A A S +Y + Y + + YN
Sbjct: 425 YLRQKDYNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYADIAVNSDRYNP 484
Query: 351 QLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCF 410
N G F Y+ ++ AL N+ + YN+G + + A CF
Sbjct: 485 AALTNKGNTVFANGDYEKAAEFYKEAL---RNDSSCTEALYNIGLTYEKLNRLDEALDCF 541
Query: 411 RLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGD 470
N AE +A + + QA L S+ P + + D+ GD
Sbjct: 542 LKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGD 601
Query: 471 LQRSYVAAQKSEAAFPDHVD 490
+++ +S FP +++
Sbjct: 602 KSQAFQYYYESYRYFPCNIE 621
>gi|189011544 ubiquitously transcribed tetratricopeptide repeat, X
chromosome [Homo sapiens]
Length = 1401
Score = 41.2 bits (95), Expect = 0.002
Identities = 21/90 (23%), Positives = 44/90 (48%)
Query: 250 TFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVL 309
++ +L + Y S+ + A ++Q +DK C I +Y++ N A + Y +
Sbjct: 286 SWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAV 345
Query: 310 KQDNTHVEAIACIGSNHFYSDQPEIALRFY 339
+ D+ H A +G+ + +QP+ A++ Y
Sbjct: 346 QLDHGHAAAWMDLGTLYESCNQPQDAIKCY 375
Score = 38.1 bits (87), Expect = 0.019
Identities = 21/103 (20%), Positives = 47/103 (45%), Gaps = 4/103 (3%)
Query: 204 ALSTEHSQYKDWWWKVQIGKCYYRLGMYREAEKQFKSAL-KQQEMVDTFLYLAKVYVSLD 262
+L + + + W++ +G+CY +G ++A ++ ++ K + DT+ + +Y +
Sbjct: 276 SLEADPNSGQSWYF---LGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQN 332
Query: 263 QPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYY 305
QP+ AL + + G + +YE N A + Y
Sbjct: 333 QPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCY 375
>gi|33188431 tetratricopeptide repeat protein isoform 3 [Homo
sapiens]
Length = 1347
Score = 41.2 bits (95), Expect = 0.002
Identities = 21/90 (23%), Positives = 44/90 (48%)
Query: 250 TFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVL 309
++ +L + Y S+ + A ++Q +DK C I +Y++ N A + Y +
Sbjct: 283 SWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAV 342
Query: 310 KQDNTHVEAIACIGSNHFYSDQPEIALRFY 339
+ D+ H A +G+ + +QP+ A++ Y
Sbjct: 343 QLDHGHAAAWMDLGTLYESCNQPQDAIKCY 372
Score = 38.1 bits (87), Expect = 0.019
Identities = 21/103 (20%), Positives = 47/103 (45%), Gaps = 4/103 (3%)
Query: 204 ALSTEHSQYKDWWWKVQIGKCYYRLGMYREAEKQFKSAL-KQQEMVDTFLYLAKVYVSLD 262
+L + + + W++ +G+CY +G ++A ++ ++ K + DT+ + +Y +
Sbjct: 273 SLEADPNSGQSWYF---LGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQN 329
Query: 263 QPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYY 305
QP+ AL + + G + +YE N A + Y
Sbjct: 330 QPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCY 372
Score = 31.6 bits (70), Expect = 1.8
Identities = 58/260 (22%), Positives = 103/260 (39%), Gaps = 28/260 (10%)
Query: 254 LAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEE----MNNMSSAAEYYKEVL 309
+A+ S + +++L + + G + L G R++E+ + A Y+ ++
Sbjct: 22 MAEGKASRESEEESVSLTVEEREALGGMDSRLFGFVRLHEDGARTKTLLGKAVRCYESLI 81
Query: 310 KQDNTHVEAIACIGSNHF------YSDQPEIALRFYRRLLQMGIY-NGQLFNNLGLCCFY 362
+ VE+ HF YS R+Y LQ + N LGL FY
Sbjct: 82 LKAEGKVESDFFCQLGHFNLLLEDYSKALSAYQRYYS--LQADYWKNAAFLYGLGLVYFY 139
Query: 363 AQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNN---- 418
+ + +F+ L + + A ++ LG + D + + F+LAL++ N
Sbjct: 140 YNAFHWAIKAFQDVLYVDPSFCRAKEIHLRLGLMFKVNTDYKSSLKHFQLALIDCNPCTL 199
Query: 419 NHAEAYNNLAVL--EMRKGH--VEQARALLQT-------ASSLAPHMYEPHFNFATISDK 467
++AE ++A L RK H E LLQT +++ + H N + DK
Sbjct: 200 SNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLPAQVKATVLQQLGWMHHNMDLVGDK 259
Query: 468 IGDLQRSYVAAQKSEAAFPD 487
+ QKS A P+
Sbjct: 260 ATKESYAIQYLQKSLEADPN 279
>gi|33188429 tetratricopeptide repeat protein isoform 1 [Homo
sapiens]
Length = 1079
Score = 41.2 bits (95), Expect = 0.002
Identities = 21/90 (23%), Positives = 44/90 (48%)
Query: 250 TFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVL 309
++ +L + Y S+ + A ++Q +DK C I +Y++ N A + Y +
Sbjct: 283 SWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAV 342
Query: 310 KQDNTHVEAIACIGSNHFYSDQPEIALRFY 339
+ D+ H A +G+ + +QP+ A++ Y
Sbjct: 343 QLDHGHAAAWMDLGTLYESCNQPQDAIKCY 372
Score = 38.1 bits (87), Expect = 0.019
Identities = 21/103 (20%), Positives = 47/103 (45%), Gaps = 4/103 (3%)
Query: 204 ALSTEHSQYKDWWWKVQIGKCYYRLGMYREAEKQFKSAL-KQQEMVDTFLYLAKVYVSLD 262
+L + + + W++ +G+CY +G ++A ++ ++ K + DT+ + +Y +
Sbjct: 273 SLEADPNSGQSWYF---LGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQN 329
Query: 263 QPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYY 305
QP+ AL + + G + +YE N A + Y
Sbjct: 330 QPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCY 372
Score = 31.6 bits (70), Expect = 1.8
Identities = 58/260 (22%), Positives = 103/260 (39%), Gaps = 28/260 (10%)
Query: 254 LAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEE----MNNMSSAAEYYKEVL 309
+A+ S + +++L + + G + L G R++E+ + A Y+ ++
Sbjct: 22 MAEGKASRESEEESVSLTVEEREALGGMDSRLFGFVRLHEDGARTKTLLGKAVRCYESLI 81
Query: 310 KQDNTHVEAIACIGSNHF------YSDQPEIALRFYRRLLQMGIY-NGQLFNNLGLCCFY 362
+ VE+ HF YS R+Y LQ + N LGL FY
Sbjct: 82 LKAEGKVESDFFCQLGHFNLLLEDYSKALSAYQRYYS--LQADYWKNAAFLYGLGLVYFY 139
Query: 363 AQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNN---- 418
+ + +F+ L + + A ++ LG + D + + F+LAL++ N
Sbjct: 140 YNAFHWAIKAFQDVLYVDPSFCRAKEIHLRLGLMFKVNTDYKSSLKHFQLALIDCNPCTL 199
Query: 419 NHAEAYNNLAVL--EMRKGH--VEQARALLQT-------ASSLAPHMYEPHFNFATISDK 467
++AE ++A L RK H E LLQT +++ + H N + DK
Sbjct: 200 SNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLPAQVKATVLQQLGWMHHNMDLVGDK 259
Query: 468 IGDLQRSYVAAQKSEAAFPD 487
+ QKS A P+
Sbjct: 260 ATKESYAIQYLQKSLEADPN 279
>gi|33188427 tetratricopeptide repeat protein isoform 2 [Homo
sapiens]
Length = 1240
Score = 41.2 bits (95), Expect = 0.002
Identities = 21/90 (23%), Positives = 44/90 (48%)
Query: 250 TFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVL 309
++ +L + Y S+ + A ++Q +DK C I +Y++ N A + Y +
Sbjct: 283 SWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAV 342
Query: 310 KQDNTHVEAIACIGSNHFYSDQPEIALRFY 339
+ D+ H A +G+ + +QP+ A++ Y
Sbjct: 343 QLDHGHAAAWMDLGTLYESCNQPQDAIKCY 372
Score = 38.1 bits (87), Expect = 0.019
Identities = 21/103 (20%), Positives = 47/103 (45%), Gaps = 4/103 (3%)
Query: 204 ALSTEHSQYKDWWWKVQIGKCYYRLGMYREAEKQFKSAL-KQQEMVDTFLYLAKVYVSLD 262
+L + + + W++ +G+CY +G ++A ++ ++ K + DT+ + +Y +
Sbjct: 273 SLEADPNSGQSWYF---LGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQN 329
Query: 263 QPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYY 305
QP+ AL + + G + +YE N A + Y
Sbjct: 330 QPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCY 372
Score = 31.6 bits (70), Expect = 1.8
Identities = 58/260 (22%), Positives = 103/260 (39%), Gaps = 28/260 (10%)
Query: 254 LAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEE----MNNMSSAAEYYKEVL 309
+A+ S + +++L + + G + L G R++E+ + A Y+ ++
Sbjct: 22 MAEGKASRESEEESVSLTVEEREALGGMDSRLFGFVRLHEDGARTKTLLGKAVRCYESLI 81
Query: 310 KQDNTHVEAIACIGSNHF------YSDQPEIALRFYRRLLQMGIY-NGQLFNNLGLCCFY 362
+ VE+ HF YS R+Y LQ + N LGL FY
Sbjct: 82 LKAEGKVESDFFCQLGHFNLLLEDYSKALSAYQRYYS--LQADYWKNAAFLYGLGLVYFY 139
Query: 363 AQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNN---- 418
+ + +F+ L + + A ++ LG + D + + F+LAL++ N
Sbjct: 140 YNAFHWAIKAFQDVLYVDPSFCRAKEIHLRLGLMFKVNTDYKSSLKHFQLALIDCNPCTL 199
Query: 419 NHAEAYNNLAVL--EMRKGH--VEQARALLQT-------ASSLAPHMYEPHFNFATISDK 467
++AE ++A L RK H E LLQT +++ + H N + DK
Sbjct: 200 SNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLPAQVKATVLQQLGWMHHNMDLVGDK 259
Query: 468 IGDLQRSYVAAQKSEAAFPD 487
+ QKS A P+
Sbjct: 260 ATKESYAIQYLQKSLEADPN 279
>gi|60685231 tetratricopeptide repeat domain 7B [Homo sapiens]
Length = 843
Score = 39.7 bits (91), Expect = 0.006
Identities = 25/111 (22%), Positives = 52/111 (46%)
Query: 247 MVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYK 306
+ +L+ A+VY+ + +P A ++ + FP +L +I E +M A +Y+
Sbjct: 695 LAQIWLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYE 754
Query: 307 EVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLG 357
E L THV+++ + + +A + R +Q+ +++N LG
Sbjct: 755 EALAISPTHVKSMQRLALILHQLGRYSLAEKILRDAVQVNSTAHEVWNGLG 805
>gi|22749211 transmembrane and tetratricopeptide repeat containing 2
[Homo sapiens]
Length = 836
Score = 38.9 bits (89), Expect = 0.011
Identities = 52/268 (19%), Positives = 99/268 (36%), Gaps = 41/268 (15%)
Query: 235 EKQFKSALKQQEMVDTFLY-LAKVYVSLDQPVTALNLFKQGLDKFPGEV---TLLCGIAR 290
++ K + V + LY L K+Y AL+++K+ + K P + +L +
Sbjct: 592 DENLKDPHAHKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNMMGE 651
Query: 291 IYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNG 350
Y ++ + A +Y E L+ H+ A G + + A + + + +++ G
Sbjct: 652 AYMRLSKLPEAEHWYMESLRSKTDHIPAHLTYGKLLALTGRKSEAEKLFLKAIELDPTKG 711
Query: 351 QLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCF 410
+ + G + + + + E A AE + DV +N H+
Sbjct: 712 NCYMHYGQ---FLLEEARLIEAAEMAKKAAELDSTEFDVVFNAAHM-------------- 754
Query: 411 RLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGD 470
L + N AE Y +LA + L P+ N I G
Sbjct: 755 -LRQASLNEAAEKYYDLA-------------------ARLRPNYPAALMNLGAILHLNGR 794
Query: 471 LQRSYVAAQKSEAAFPDHVDTQHLIKQL 498
LQ++ ++ PD V TQ +++L
Sbjct: 795 LQKAEANYLRALQLKPDDVITQSNLRKL 822
Score = 35.8 bits (81), Expect = 0.094
Identities = 29/124 (23%), Positives = 56/124 (45%), Gaps = 4/124 (3%)
Query: 353 FNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRL 412
+ NLG + +++ AL N AD+ YNLG + A ++L
Sbjct: 496 WGNLGNVLKSQSKISEAESAYRNALYYRSN---MADMLYNLGLLLQENSRFAEALHYYKL 552
Query: 413 ALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLA-PHMYEPHFNFATISDKIGDL 471
A+ + A AY N ++ M +G E+AR S + ++ +PH + ++++ + +L
Sbjct: 553 AIGSRPTLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNL 612
Query: 472 QRSY 475
+ Y
Sbjct: 613 GKLY 616
Score = 29.6 bits (65), Expect = 6.7
Identities = 20/78 (25%), Positives = 30/78 (38%)
Query: 387 ADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQT 446
A W NLG+V + A +R AL +N A+ NL +L +A +
Sbjct: 493 AKAWGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENSRFAEALHYYKL 552
Query: 447 ASSLAPHMYEPHFNFATI 464
A P + + N I
Sbjct: 553 AIGSRPTLASAYLNTGII 570
>gi|4507711 tetratricopeptide repeat domain 1 [Homo sapiens]
Length = 292
Score = 38.5 bits (88), Expect = 0.014
Identities = 28/108 (25%), Positives = 49/108 (45%), Gaps = 7/108 (6%)
Query: 222 GKCYYRLGMYREAEKQFKSALK------QQEMVDTFLYLAKVYVSLDQPVTALNLFKQGL 275
G ++ G Y EAE + AL+ Q+E F A + D+ A+N + +
Sbjct: 123 GNEQFKKGDYIEAESSYSRALEMCPSCFQKERSILFSNRAAARMKQDKKEMAINDCSKAI 182
Query: 276 DKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQD-NTHVEAIACI 322
P + + A +YE+ + + A E YK +L++D + H AC+
Sbjct: 183 QLNPSYIRAILRRAELYEKTDKLDEALEDYKSILEKDPSIHQAREACM 230
>gi|34304360 nephrocystin 3 [Homo sapiens]
Length = 1330
Score = 36.6 bits (83), Expect = 0.055
Identities = 69/278 (24%), Positives = 109/278 (39%), Gaps = 62/278 (22%)
Query: 225 YYRLGMYREAE----KQFK---SALKQQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDK 277
Y + Y +AE K FK A+K++ + F L + + L++ L L K
Sbjct: 1037 YQKQNKYEQAEHFRKKSFKIHQKAIKKKGNLYGFALLRRRALQLEE----LTLGKDT--- 1089
Query: 278 FPGEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALR 337
P L + +Y NN+ +A ++ K L+ +G +H P+ A
Sbjct: 1090 -PDNARTLNELGVLYYLQNNLETADQFLKRSLEMRER------VLGPDH-----PDCA-- 1135
Query: 338 FYRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSLAEN--EEEAADVWYNLGH 395
Q NNL C +QYD +ERAL + + + Y + H
Sbjct: 1136 -------------QSLNNLAALCNEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKH 1182
Query: 396 VAV---GIGDTNLAHQCFRLAL--------VNNNNHAEAYNNLAVL-EMRKGHVE----Q 439
+A+ +G + A + LA+ + + A A NLAVL K HVE
Sbjct: 1183 LAILYKKMGKLDKAVPLYELAVEIRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLY 1242
Query: 440 ARALLQTASSLA---PHMYEPHFNFATISDKIGDLQRS 474
RAL SL P + E N A +S + GD +++
Sbjct: 1243 ERALKIYEDSLGRMHPRVGETLKNLAVLSYEGGDFEKA 1280
>gi|118402596 cell division cycle protein 23 [Homo sapiens]
Length = 597
Score = 36.6 bits (83), Expect = 0.055
Identities = 35/163 (21%), Positives = 64/163 (39%), Gaps = 3/163 (1%)
Query: 248 VDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKE 307
V+T + Y Q A F++ L P + + Y EM N S+A + Y+
Sbjct: 331 VETCCVIGNYYSLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRH 390
Query: 308 VLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYD 367
++ + A +G + P L +YRR Q+ + ++ LG C Q
Sbjct: 391 AIEVNKRDYRAWYGLGQTYEILKMPFYCLYYYRRAHQLRPNDSRMLVALGECYEKLNQLV 450
Query: 368 MTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCF 410
+ RA ++ + E+ A L + + ++ A QC+
Sbjct: 451 EAKKCYWRAYAVGDVEKMAL---VKLAKLHEQLTESEQAAQCY 490
>gi|40548372 tetratricopeptide repeat domain 15 [Homo sapiens]
Length = 735
Score = 35.8 bits (81), Expect = 0.094
Identities = 33/147 (22%), Positives = 61/147 (41%), Gaps = 7/147 (4%)
Query: 254 LAKVYVSLDQPVTALNLFKQGLDKFPG-EVTLLCGIARIYEEMNNMSSAAEYYKEV---- 308
+A + + V A+ + + +P E LL GI RI ++ ++ +A +Y+++V
Sbjct: 551 MANCLLLMKDYVLAVEAYHSVIKYYPEQEPQLLSGIGRISLQIGDIKTAEKYFQDVEKVT 610
Query: 309 LKQDNTHVEAIACIGSNHFYSDQPEIAL--RFYRRLLQMGIYNGQLFNNLGLCCFYAQQY 366
K D + + + S + Q A RF+ +L+M N NN +C Y +
Sbjct: 611 QKLDGLQGKIMVLMNSAFLHLGQNNFAEAHRFFTEILRMDPRNAVANNNAAVCLLYLGKL 670
Query: 367 DMTLTSFERALSLAENEEEAADVWYNL 393
+L E + V +NL
Sbjct: 671 KDSLRQLEAMVQQDPRHYLHESVLFNL 697
Score = 29.6 bits (65), Expect = 6.7
Identities = 21/82 (25%), Positives = 37/82 (45%), Gaps = 6/82 (7%)
Query: 231 YREAEKQFKSALKQQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIAR 290
Y E E Q S + + + + A+ Y + VT Q LD G++ +L A
Sbjct: 575 YPEQEPQLLSGIGRISLQIGDIKTAEKYFQDVEKVT------QKLDGLQGKIMVLMNSAF 628
Query: 291 IYEEMNNMSSAAEYYKEVLKQD 312
++ NN + A ++ E+L+ D
Sbjct: 629 LHLGQNNFAEAHRFFTEILRMD 650
>gi|153082755 interferon-induced protein with tetratricopeptide
repeats 2 [Homo sapiens]
Length = 472
Score = 34.7 bits (78), Expect = 0.21
Identities = 31/129 (24%), Positives = 54/129 (41%), Gaps = 20/129 (15%)
Query: 233 EAEKQFKSAL-KQQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGI--- 288
E EK + AL K + D AK Y D+P A+ L K+ L+ P L C I
Sbjct: 231 EGEKLVEEALEKAPGVTDVLRSAAKFYRRKDEPDKAIELLKKALEYIPNNAYLHCQIGCC 290
Query: 289 --ARIYEEMN--------------NMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQP 332
A++++ MN + A + K+ + ++ + + S H +DQ
Sbjct: 291 YRAKVFQVMNLRENGMYGKRKLLELIGHAVAHLKKADEANDNLFRVCSILASLHALADQY 350
Query: 333 EIALRFYRR 341
E A ++++
Sbjct: 351 EDAEYYFQK 359
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.133 0.395
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,726,505
Number of Sequences: 37866
Number of extensions: 761997
Number of successful extensions: 2611
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 36
Number of HSP's successfully gapped in prelim test: 36
Number of HSP's that attempted gapping in prelim test: 2366
Number of HSP's gapped (non-prelim): 206
length of query: 505
length of database: 18,247,518
effective HSP length: 107
effective length of query: 398
effective length of database: 14,195,856
effective search space: 5649950688
effective search space used: 5649950688
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.